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PMC:1860061 / 3761-5028 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T2912 0-10 NN denotes Microarray
T2914 10-11 HYPH denotes -
T2913 11-16 VBN denotes based
T2916 17-23 JJ denotes global
T2917 24-28 NN denotes gene
T2915 29-39 NN denotes expression
T2918 40-42 VBZ denotes is
T2919 43-44 DT denotes a
T2921 45-53 JJ denotes powerful
T2920 54-63 NN denotes technique
T2922 64-67 IN denotes for
T2923 68-81 VBG denotes investigating
T2924 82-89 JJ denotes complex
T2925 90-98 NNS denotes diseases
T2926 98-99 . denotes .
T2927 99-200 sentence denotes During disease development, genes involved in the disease are likely to be differentially regulated.
T2928 100-106 IN denotes During
T2930 107-114 NN denotes disease
T2931 115-126 NN denotes development
T2932 126-128 , denotes ,
T2933 128-133 NNS denotes genes
T2934 134-142 VBN denotes involved
T2935 143-145 IN denotes in
T2936 146-149 DT denotes the
T2937 150-157 NN denotes disease
T2929 158-161 VBP denotes are
T2938 162-168 JJ denotes likely
T2939 169-171 TO denotes to
T2941 172-174 VB denotes be
T2942 175-189 RB denotes differentially
T2940 190-199 VBN denotes regulated
T2943 199-200 . denotes .
T2944 200-363 sentence denotes Therefore, signature genes of the diseases could be identified by detecting the expression patterns of the disease-related cells/tissues and their ideal controls.
T2945 201-210 RB denotes Therefore
T2947 210-212 , denotes ,
T2948 212-221 NN denotes signature
T2949 222-227 NNS denotes genes
T2950 228-230 IN denotes of
T2951 231-234 DT denotes the
T2952 235-243 NNS denotes diseases
T2953 244-249 MD denotes could
T2954 250-252 VB denotes be
T2946 253-263 VBN denotes identified
T2955 264-266 IN denotes by
T2956 267-276 VBG denotes detecting
T2957 277-280 DT denotes the
T2959 281-291 NN denotes expression
T2958 292-300 NNS denotes patterns
T2960 301-303 IN denotes of
T2961 304-307 DT denotes the
T2963 308-315 NN denotes disease
T2965 315-316 HYPH denotes -
T2964 316-323 VBN denotes related
T2966 324-329 NNS denotes cells
T2967 329-330 HYPH denotes /
T2962 330-337 NNS denotes tissues
T2968 338-341 CC denotes and
T2969 342-347 PRP$ denotes their
T2971 348-353 JJ denotes ideal
T2970 354-362 NNS denotes controls
T2972 362-363 . denotes .
T2973 363-467 sentence denotes In the past decade, many studies applied this technique to study both RA and its animal models [15-22].
T2974 364-366 IN denotes In
T2976 367-370 DT denotes the
T2978 371-375 JJ denotes past
T2977 376-382 NN denotes decade
T2979 382-384 , denotes ,
T2980 384-388 JJ denotes many
T2981 389-396 NNS denotes studies
T2975 397-404 VBD denotes applied
T2982 405-409 DT denotes this
T2983 410-419 NN denotes technique
T2984 420-422 TO denotes to
T2985 423-428 VB denotes study
T2986 429-433 CC denotes both
T2987 434-436 NN denotes RA
T2988 437-440 CC denotes and
T2989 441-444 PRP$ denotes its
T2991 445-451 NN denotes animal
T2990 452-458 NNS denotes models
T2992 459-460 -LRB- denotes [
T2993 460-462 CD denotes 15
T2994 462-463 SYM denotes -
T2995 463-465 CD denotes 22
T2996 465-466 -RRB- denotes ]
T2997 466-467 . denotes .
T2998 467-596 sentence denotes Indeed, genes involved in arthritis show distinct expression patterns in certain tissues and pathological stages of the disease.
T2999 468-474 RB denotes Indeed
T3001 474-476 , denotes ,
T3002 476-481 NNS denotes genes
T3003 482-490 VBN denotes involved
T3004 491-493 IN denotes in
T3005 494-503 NN denotes arthritis
T3000 504-508 VBP denotes show
T3006 509-517 JJ denotes distinct
T3008 518-528 NN denotes expression
T3007 529-537 NNS denotes patterns
T3009 538-540 IN denotes in
T3010 541-548 JJ denotes certain
T3011 549-556 NNS denotes tissues
T3012 557-560 CC denotes and
T3013 561-573 JJ denotes pathological
T3014 574-580 NNS denotes stages
T3015 581-583 IN denotes of
T3016 584-587 DT denotes the
T3017 588-595 NN denotes disease
T3018 595-596 . denotes .
T3019 596-713 sentence denotes Genes involved in immunoinflammatory responses were differentially expressed in the blood cells in RA patients [18].
T3020 597-602 NNS denotes Genes
T3022 603-611 VBN denotes involved
T3023 612-614 IN denotes in
T3024 615-633 JJ denotes immunoinflammatory
T3025 634-643 NNS denotes responses
T3026 644-648 VBD denotes were
T3027 649-663 RB denotes differentially
T3021 664-673 VBN denotes expressed
T3028 674-676 IN denotes in
T3029 677-680 DT denotes the
T3031 681-686 NN denotes blood
T3030 687-692 NNS denotes cells
T3032 693-695 IN denotes in
T3033 696-698 NN denotes RA
T3034 699-707 NNS denotes patients
T3035 708-709 -LRB- denotes [
T3036 709-711 CD denotes 18
T3037 711-712 -RRB- denotes ]
T3038 712-713 . denotes .
T3039 713-996 sentence denotes Chemokines and adhesion molecules were upregulated in the joint at the initiation phase of arthritis in animal models [21,22], while genes involved in cartilage destruction and bone erosion were differentially expressed at the late phase of arthritis in animal models of RA [15,16].
T3040 714-724 NNS denotes Chemokines
T3042 725-728 CC denotes and
T3043 729-737 NN denotes adhesion
T3044 738-747 NNS denotes molecules
T3045 748-752 VBD denotes were
T3041 753-764 VBN denotes upregulated
T3046 765-767 IN denotes in
T3047 768-771 DT denotes the
T3048 772-777 NN denotes joint
T3049 778-780 IN denotes at
T3050 781-784 DT denotes the
T3052 785-795 NN denotes initiation
T3051 796-801 NN denotes phase
T3053 802-804 IN denotes of
T3054 805-814 NN denotes arthritis
T3055 815-817 IN denotes in
T3056 818-824 NN denotes animal
T3057 825-831 NNS denotes models
T3058 832-833 -LRB- denotes [
T3060 833-835 CD denotes 21
T3061 835-836 , denotes ,
T3059 836-838 CD denotes 22
T3062 838-839 -RRB- denotes ]
T3063 839-841 , denotes ,
T3064 841-846 IN denotes while
T3066 847-852 NNS denotes genes
T3067 853-861 VBN denotes involved
T3068 862-864 IN denotes in
T3069 865-874 NN denotes cartilage
T3070 875-886 NN denotes destruction
T3071 887-890 CC denotes and
T3072 891-895 NN denotes bone
T3073 896-903 NN denotes erosion
T3074 904-908 VBD denotes were
T3075 909-923 RB denotes differentially
T3065 924-933 VBN denotes expressed
T3076 934-936 IN denotes at
T3077 937-940 DT denotes the
T3079 941-945 JJ denotes late
T3078 946-951 NN denotes phase
T3080 952-954 IN denotes of
T3081 955-964 NN denotes arthritis
T3082 965-967 IN denotes in
T3083 968-974 NN denotes animal
T3084 975-981 NNS denotes models
T3085 982-984 IN denotes of
T3086 985-987 NN denotes RA
T3087 988-989 -LRB- denotes [
T3089 989-991 CD denotes 15
T3090 991-992 , denotes ,
T3088 992-994 CD denotes 16
T3091 994-995 -RRB- denotes ]
T3092 995-996 . denotes .
T3093 996-1267 sentence denotes Besides detecting genes involved in complex diseases, microarrays could also be used to detect the genetic polymorphisms regulating gene expression because differential expressions between two strains might be the result of a polymorphism located in regulatory elements.
T3094 997-1004 IN denotes Besides
T3095 1005-1014 VBG denotes detecting
T3097 1015-1020 NNS denotes genes
T3098 1021-1029 VBN denotes involved
T3099 1030-1032 IN denotes in
T3100 1033-1040 JJ denotes complex
T3101 1041-1049 NNS denotes diseases
T3102 1049-1051 , denotes ,
T3103 1051-1062 NNS denotes microarrays
T3104 1063-1068 MD denotes could
T3105 1069-1073 RB denotes also
T3106 1074-1076 VB denotes be
T3096 1077-1081 VBN denotes used
T3107 1082-1084 TO denotes to
T3108 1085-1091 VB denotes detect
T3109 1092-1095 DT denotes the
T3111 1096-1103 JJ denotes genetic
T3110 1104-1117 NNS denotes polymorphisms
T3112 1118-1128 VBG denotes regulating
T3113 1129-1133 NN denotes gene
T3114 1134-1144 NN denotes expression
T3115 1145-1152 IN denotes because
T3117 1153-1165 JJ denotes differential
T3118 1166-1177 NNS denotes expressions
T3119 1178-1185 IN denotes between
T3120 1186-1189 CD denotes two
T3121 1190-1197 NNS denotes strains
T3122 1198-1203 MD denotes might
T3116 1204-1206 VB denotes be
T3123 1207-1210 DT denotes the
T3124 1211-1217 NN denotes result
T3125 1218-1220 IN denotes of
T3126 1221-1222 DT denotes a
T3127 1223-1235 NN denotes polymorphism
T3128 1236-1243 VBN denotes located
T3129 1244-1246 IN denotes in
T3130 1247-1257 JJ denotes regulatory
T3131 1258-1266 NNS denotes elements
T3132 1266-1267 . denotes .
R650 T2978 T2977 amod past,decade
R651 T2979 T2975 punct ", ",applied
R653 T2980 T2981 amod many,studies
R654 T2981 T2975 nsubj studies,applied
R656 T2982 T2983 det this,technique
R657 T2983 T2975 dobj technique,applied
R659 T2984 T2985 aux to,study
R660 T2985 T2975 advcl study,applied
R661 T2986 T2987 preconj both,RA
R662 T2987 T2985 dobj RA,study
R664 T2988 T2987 cc and,RA
R665 T2989 T2990 poss its,models
R667 T2990 T2987 conj models,RA
R668 T2991 T2990 compound animal,models
R669 T2992 T2993 punct [,15
R671 T2993 T2975 parataxis 15,applied
R672 T2994 T2995 punct -,22
R673 T2995 T2993 prep 22,15
R675 T2996 T2993 punct ],15
R676 T2997 T2975 punct .,applied
R678 T2999 T3000 advmod Indeed,show
R679 T3001 T3000 punct ", ",show
R680 T3002 T3000 nsubj genes,show
R681 T3003 T3002 acl involved,genes
R683 T3004 T3003 prep in,involved
R684 T3005 T3004 pobj arthritis,in
R685 T3006 T3007 amod distinct,patterns
R686 T3007 T3000 dobj patterns,show
R688 T3008 T3007 compound expression,patterns
R689 T3009 T3007 prep in,patterns
R690 T3010 T3011 amod certain,tissues
R692 T3011 T3009 pobj tissues,in
R693 T3012 T3011 cc and,tissues
R694 T3013 T3014 amod pathological,stages
R696 T3014 T3011 conj stages,tissues
R697 T3015 T3014 prep of,stages
R698 T3016 T3017 det the,disease
R700 T3017 T3015 pobj disease,of
R701 T3018 T3000 punct .,show
R703 T3020 T3021 nsubjpass Genes,expressed
R705 T3022 T3020 acl involved,Genes
R706 T3023 T3022 prep in,involved
R707 T3024 T3025 amod immunoinflammatory,responses
R708 T3025 T3023 pobj responses,in
R710 T3026 T3021 auxpass were,expressed
R711 T3027 T3021 advmod differentially,expressed
R712 T3028 T3021 prep in,expressed
R713 T2912 T2913 npadvmod Microarray,based
R714 T3029 T3030 det the,cells
R715 T3030 T3028 pobj cells,in
R716 T3031 T3030 compound blood,cells
R717 T3032 T3021 prep in,expressed
R718 T2913 T2915 amod based,expression
R719 T3033 T3034 compound RA,patients
R720 T3034 T3032 pobj patients,in
R721 T3035 T3036 punct [,18
R722 T2914 T2913 punct -,based
R723 T3036 T3021 parataxis 18,expressed
R724 T3037 T3036 punct ],18
R725 T3038 T3021 punct .,expressed
R726 T2915 T2918 nsubj expression,is
R727 T2916 T2915 amod global,expression
R728 T2917 T2915 compound gene,expression
R729 T3040 T3041 nsubjpass Chemokines,upregulated
R730 T2919 T2920 det a,technique
R731 T3042 T3040 cc and,Chemokines
R732 T3043 T3044 compound adhesion,molecules
R733 T3044 T3040 conj molecules,Chemokines
R734 T3045 T3041 auxpass were,upregulated
R735 T3046 T3041 prep in,upregulated
R736 T3047 T3048 det the,joint
R737 T3048 T3046 pobj joint,in
R738 T2920 T2918 attr technique,is
R739 T3049 T3041 prep at,upregulated
R740 T3050 T3051 det the,phase
R741 T3051 T3049 pobj phase,at
R742 T2921 T2920 amod powerful,technique
R743 T3052 T3051 compound initiation,phase
R744 T2922 T2920 prep for,technique
R745 T3053 T3051 prep of,phase
R746 T3054 T3053 pobj arthritis,of
R747 T3055 T3041 prep in,upregulated
R748 T3056 T3057 compound animal,models
R749 T2923 T2922 pcomp investigating,for
R750 T3057 T3055 pobj models,in
R751 T3058 T3059 punct [,22
R752 T3059 T3041 parataxis 22,upregulated
R753 T2924 T2925 amod complex,diseases
R754 T3060 T3059 nummod 21,22
R755 T3061 T3059 punct ",",22
R756 T3062 T3059 punct ],22
R757 T2925 T2923 dobj diseases,investigating
R758 T3063 T3041 punct ", ",upregulated
R759 T3064 T3065 mark while,expressed
R760 T2926 T2918 punct .,is
R761 T3065 T3041 advcl expressed,upregulated
R762 T3066 T3065 nsubjpass genes,expressed
R763 T3067 T3066 acl involved,genes
R764 T3068 T3067 prep in,involved
R765 T2928 T2929 prep During,are
R766 T3069 T3070 compound cartilage,destruction
R767 T3070 T3068 pobj destruction,in
R768 T3071 T3070 cc and,destruction
R769 T3072 T3073 compound bone,erosion
R770 T2930 T2931 compound disease,development
R771 T3073 T3070 conj erosion,destruction
R772 T3074 T3065 auxpass were,expressed
R773 T3075 T3065 advmod differentially,expressed
R774 T3076 T3065 prep at,expressed
R775 T2931 T2928 pobj development,During
R776 T3077 T3078 det the,phase
R777 T3078 T3076 pobj phase,at
R778 T3079 T3078 amod late,phase
R779 T2932 T2929 punct ", ",are
R780 T3080 T3078 prep of,phase
R781 T3081 T3080 pobj arthritis,of
R782 T3082 T3065 prep in,expressed
R783 T2933 T2929 nsubj genes,are
R784 T3083 T3084 compound animal,models
R785 T2934 T2933 acl involved,genes
R786 T2935 T2934 prep in,involved
R787 T3084 T3082 pobj models,in
R788 T2936 T2937 det the,disease
R789 T3085 T3084 prep of,models
R790 T3086 T3085 pobj RA,of
R791 T3087 T3088 punct [,16
R792 T2937 T2935 pobj disease,in
R793 T3088 T3065 parataxis 16,expressed
R794 T3089 T3088 nummod 15,16
R795 T2938 T2929 acomp likely,are
R796 T3090 T3088 punct ",",16
R797 T2939 T2940 aux to,regulated
R798 T3091 T3088 punct ],16
R799 T3092 T3041 punct .,upregulated
R800 T3094 T3095 mark Besides,detecting
R801 T2940 T2938 xcomp regulated,likely
R802 T3095 T3096 advcl detecting,used
R803 T2941 T2940 auxpass be,regulated
R804 T3097 T3095 dobj genes,detecting
R805 T3098 T3097 acl involved,genes
R806 T3099 T3098 prep in,involved
R807 T2942 T2940 advmod differentially,regulated
R808 T3100 T3101 amod complex,diseases
R809 T3101 T3099 pobj diseases,in
R810 T3102 T3096 punct ", ",used
R811 T3103 T3096 nsubjpass microarrays,used
R812 T2943 T2929 punct .,are
R813 T3104 T3096 aux could,used
R814 T3105 T3096 advmod also,used
R815 T3106 T3096 auxpass be,used
R816 T2945 T2946 advmod Therefore,identified
R817 T3107 T3108 aux to,detect
R818 T3108 T3096 advcl detect,used
R819 T3109 T3110 det the,polymorphisms
R820 T3110 T3108 dobj polymorphisms,detect
R821 T2947 T2946 punct ", ",identified
R822 T3111 T3110 amod genetic,polymorphisms
R823 T3112 T3110 acl regulating,polymorphisms
R824 T3113 T3114 compound gene,expression
R825 T3114 T3112 dobj expression,regulating
R826 T3115 T3116 mark because,be
R827 T2948 T2949 compound signature,genes
R828 T3116 T3108 advcl be,detect
R829 T3117 T3118 amod differential,expressions
R830 T2949 T2946 nsubjpass genes,identified
R831 T3118 T3116 nsubj expressions,be
R832 T3119 T3118 prep between,expressions
R833 T3120 T3121 nummod two,strains
R834 T2950 T2949 prep of,genes
R835 T3121 T3119 pobj strains,between
R836 T3122 T3116 aux might,be
R837 T3123 T3124 det the,result
R838 T3124 T3116 attr result,be
R839 T2951 T2952 det the,diseases
R840 T3125 T3124 prep of,result
R841 T3126 T3127 det a,polymorphism
R842 T3127 T3125 pobj polymorphism,of
R843 T2952 T2950 pobj diseases,of
R844 T3128 T3127 acl located,polymorphism
R845 T3129 T3128 prep in,located
R846 T3130 T3131 amod regulatory,elements
R847 T2953 T2946 aux could,identified
R848 T3131 T3129 pobj elements,in
R849 T3132 T3096 punct .,used
R850 T2954 T2946 auxpass be,identified
R853 T2955 T2946 prep by,identified
R856 T2956 T2955 pcomp detecting,by
R861 T2957 T2958 det the,patterns
R865 T2958 T2956 dobj patterns,detecting
R869 T2959 T2958 compound expression,patterns
R870 T2960 T2958 prep of,patterns
R872 T2961 T2962 det the,tissues
R876 T2962 T2960 pobj tissues,of
R879 T2963 T2964 npadvmod disease,related
R883 T2964 T2962 amod related,tissues
R887 T2965 T2964 punct -,related
R895 T2966 T2962 compound cells,tissues
R898 T2967 T2962 punct /,tissues
R901 T2968 T2962 cc and,tissues
R903 T2969 T2970 poss their,controls
R908 T2970 T2962 conj controls,tissues
R912 T2971 T2970 amod ideal,controls
R916 T2972 T2946 punct .,identified
R920 T2974 T2975 prep In,applied
R923 T2976 T2977 det the,decade
R924 T2977 T2974 pobj decade,In