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Id Subject Object Predicate Lexical cue
T13481 11-13 IN denotes In
T13483 14-18 DT denotes this
T13484 19-24 NN denotes study
T13485 24-26 , denotes ,
T13486 26-28 PRP denotes we
T13482 29-38 VBD denotes attempted
T13487 39-42 IN denotes for
T13488 43-46 DT denotes the
T13490 47-52 JJ denotes first
T13489 53-57 NN denotes time
T13491 58-60 TO denotes to
T13492 61-69 VB denotes identify
T13493 70-75 JJ denotes small
T13495 75-76 HYPH denotes -
T13494 76-82 NN denotes effect
T13496 83-86 NNS denotes QTL
T13497 87-89 IN denotes in
T13498 90-92 DT denotes an
T13500 93-95 NN denotes F2
T13499 96-103 NN denotes progeny
T13501 103-104 . denotes .
T13502 104-277 sentence denotes Small-effect QTL are defined as those reaching the threshold value of P = 0.05 but that did not reach the significant threshold value suggested by Lander and Botstein [26].
T13503 105-110 JJ denotes Small
T13505 110-111 HYPH denotes -
T13504 111-117 NN denotes effect
T13506 118-121 NNS denotes QTL
T13508 122-125 VBP denotes are
T13507 126-133 VBN denotes defined
T13509 134-136 IN denotes as
T13510 137-142 DT denotes those
T13511 143-151 VBG denotes reaching
T13512 152-155 DT denotes the
T13514 156-165 NN denotes threshold
T13513 166-171 NN denotes value
T13515 172-174 IN denotes of
T13516 175-176 NN denotes P
T13518 177-178 SYM denotes =
T13517 179-183 CD denotes 0.05
T13519 184-187 CC denotes but
T13520 188-192 DT denotes that
T13522 193-196 VBD denotes did
T13523 197-200 RB denotes not
T13521 201-206 VB denotes reach
T13524 207-210 DT denotes the
T13526 211-222 JJ denotes significant
T13527 223-232 NN denotes threshold
T13525 233-238 NN denotes value
T13528 239-248 VBN denotes suggested
T13529 249-251 IN denotes by
T13530 252-258 NNP denotes Lander
T13531 259-262 CC denotes and
T13532 263-271 NNP denotes Botstein
T13533 272-273 -LRB- denotes [
T13534 273-275 CD denotes 26
T13535 275-276 -RRB- denotes ]
T13536 276-277 . denotes .
T13537 277-406 sentence denotes Although not significant, there is evidence that most of the eight small-effect QTL likely contain susceptibility genes for CIA.
T13538 278-286 IN denotes Although
T13540 287-290 RB denotes not
T13539 291-302 JJ denotes significant
T13542 302-304 , denotes ,
T13543 304-309 EX denotes there
T13541 310-312 VBZ denotes is
T13544 313-321 NN denotes evidence
T13545 322-326 IN denotes that
T13547 327-331 JJS denotes most
T13548 332-334 IN denotes of
T13549 335-338 DT denotes the
T13551 339-344 CD denotes eight
T13552 345-350 JJ denotes small
T13554 350-351 HYPH denotes -
T13553 351-357 NN denotes effect
T13550 358-361 NNS denotes QTL
T13555 362-368 RB denotes likely
T13546 369-376 VBP denotes contain
T13556 377-391 NN denotes susceptibility
T13557 392-397 NNS denotes genes
T13558 398-401 IN denotes for
T13559 402-405 NN denotes CIA
T13560 405-406 . denotes .
T13561 406-541 sentence denotes First, we performed the linkage analysis in three datasets, including all 290 F progeny, 76 C5+/+ F2 progeny and 133 C5+/- F2 progeny.
T13562 407-412 RB denotes First
T13564 412-414 , denotes ,
T13565 414-416 PRP denotes we
T13563 417-426 VBD denotes performed
T13566 427-430 DT denotes the
T13568 431-438 NN denotes linkage
T13567 439-447 NN denotes analysis
T13569 448-450 IN denotes in
T13570 451-456 CD denotes three
T13571 457-465 NNS denotes datasets
T13572 465-467 , denotes ,
T13573 467-476 VBG denotes including
T13574 477-480 DT denotes all
T13576 481-484 CD denotes 290
T13577 485-486 NN denotes F
T13575 487-494 NN denotes progeny
T13578 494-496 , denotes ,
T13579 496-498 CD denotes 76
T13581 499-502 NN denotes C5+
T13582 502-503 HYPH denotes /
T13583 503-504 SYM denotes +
T13584 505-507 NN denotes F2
T13580 508-515 NN denotes progeny
T13585 516-519 CC denotes and
T13586 520-523 CD denotes 133
T13588 524-527 NN denotes C5+
T13589 527-528 HYPH denotes /
T13590 528-529 SYM denotes -
T13591 530-532 NN denotes F2
T13587 533-540 NN denotes progeny
T13592 540-541 . denotes .
T13593 541-662 sentence denotes Five of the eight small-effect QTL were identified in at least two datasets, suggesting that these QTL are reproducible.
T13594 542-546 CD denotes Five
T13596 547-549 IN denotes of
T13597 550-553 DT denotes the
T13595 554-559 CD denotes eight
T13599 560-565 JJ denotes small
T13601 565-566 HYPH denotes -
T13600 566-572 NN denotes effect
T13598 573-576 NNS denotes QTL
T13603 577-581 VBD denotes were
T13602 582-592 VBN denotes identified
T13604 593-595 IN denotes in
T13605 596-598 RB denotes at
T13607 599-604 RBS denotes least
T13606 605-608 CD denotes two
T13608 609-617 NNS denotes datasets
T13609 617-619 , denotes ,
T13610 619-629 VBG denotes suggesting
T13611 630-634 IN denotes that
T13613 635-640 DT denotes these
T13614 641-644 NNS denotes QTL
T13612 645-648 VBP denotes are
T13615 649-661 JJ denotes reproducible
T13616 661-662 . denotes .
T13617 662-791 sentence denotes Second, many QTL identified in the present study overlap with arthritis QTL previously identified, including loci 1, 2, 5 and 6.
T13618 663-669 RB denotes Second
T13620 669-671 , denotes ,
T13621 671-675 JJ denotes many
T13622 676-679 NNS denotes QTL
T13623 680-690 VBN denotes identified
T13624 691-693 IN denotes in
T13625 694-697 DT denotes the
T13627 698-705 JJ denotes present
T13626 706-711 NN denotes study
T13619 712-719 VBP denotes overlap
T13628 720-724 IN denotes with
T13629 725-734 NN denotes arthritis
T13630 735-738 NNS denotes QTL
T13631 739-749 RB denotes previously
T13632 750-760 VBN denotes identified
T13633 760-762 , denotes ,
T13634 762-771 VBG denotes including
T13635 772-776 NNS denotes loci
T13636 777-778 CD denotes 1
T13637 778-780 , denotes ,
T13638 780-781 CD denotes 2
T13639 781-783 , denotes ,
T13640 783-784 CD denotes 5
T13641 785-788 CC denotes and
T13642 789-790 CD denotes 6
T13643 790-791 . denotes .
T13644 791-933 sentence denotes In addition, syntenic analysis revealed that the counterpart genomic regions on the human genome of many of these eight QTL are linked to RA.
T13645 792-794 IN denotes In
T13647 795-803 NN denotes addition
T13648 803-805 , denotes ,
T13649 805-813 JJ denotes syntenic
T13650 814-822 NN denotes analysis
T13646 823-831 VBD denotes revealed
T13651 832-836 IN denotes that
T13653 837-840 DT denotes the
T13655 841-852 NN denotes counterpart
T13656 853-860 JJ denotes genomic
T13654 861-868 NNS denotes regions
T13657 869-871 IN denotes on
T13658 872-875 DT denotes the
T13660 876-881 JJ denotes human
T13659 882-888 NN denotes genome
T13661 889-891 IN denotes of
T13662 892-896 JJ denotes many
T13663 897-899 IN denotes of
T13664 900-905 DT denotes these
T13666 906-911 CD denotes eight
T13665 912-915 NNS denotes QTL
T13667 916-919 VBP denotes are
T13652 920-926 VBN denotes linked
T13668 927-929 IN denotes to
T13669 930-932 NN denotes RA
T13670 932-933 . denotes .
T13671 933-1190 sentence denotes For five of the eight small-effect QTL the DBA/1 alleles are the arthritis-enhancing alleles, while the FVBN alleles are the arthritis-enhancing alleles in the other three QTL, indicating that some susceptibility genes could come from the resistant strain.
T13672 934-937 IN denotes For
T13674 938-942 CD denotes five
T13676 943-945 IN denotes of
T13677 946-949 DT denotes the
T13675 950-955 CD denotes eight
T13679 956-961 JJ denotes small
T13681 961-962 HYPH denotes -
T13680 962-968 NN denotes effect
T13678 969-972 NNS denotes QTL
T13682 973-976 DT denotes the
T13684 977-980 NN denotes DBA
T13685 980-981 HYPH denotes /
T13686 981-982 CD denotes 1
T13683 983-990 NNS denotes alleles
T13673 991-994 VBP denotes are
T13687 995-998 DT denotes the
T13689 999-1008 NN denotes arthritis
T13691 1008-1009 HYPH denotes -
T13690 1009-1018 VBG denotes enhancing
T13688 1019-1026 NNS denotes alleles
T13692 1026-1028 , denotes ,
T13693 1028-1033 IN denotes while
T13695 1034-1037 DT denotes the
T13697 1038-1042 NN denotes FVBN
T13696 1043-1050 NNS denotes alleles
T13694 1051-1054 VBP denotes are
T13698 1055-1058 DT denotes the
T13700 1059-1068 NN denotes arthritis
T13702 1068-1069 HYPH denotes -
T13701 1069-1078 VBG denotes enhancing
T13699 1079-1086 NNS denotes alleles
T13703 1087-1089 IN denotes in
T13704 1090-1093 DT denotes the
T13706 1094-1099 JJ denotes other
T13707 1100-1105 CD denotes three
T13705 1106-1109 NNS denotes QTL
T13708 1109-1111 , denotes ,
T13709 1111-1121 VBG denotes indicating
T13710 1122-1126 IN denotes that
T13712 1127-1131 DT denotes some
T13714 1132-1146 NN denotes susceptibility
T13713 1147-1152 NNS denotes genes
T13715 1153-1158 MD denotes could
T13711 1159-1163 VB denotes come
T13716 1164-1168 IN denotes from
T13717 1169-1172 DT denotes the
T13719 1173-1182 JJ denotes resistant
T13718 1183-1189 NN denotes strain
T13720 1189-1190 . denotes .
T13721 1190-1313 sentence denotes Interestingly, loci 2 and 7 partially overlap with two arthritis-related QTL identified by us in the same F2 progeny [10].
T13722 1191-1204 RB denotes Interestingly
T13724 1204-1206 , denotes ,
T13725 1206-1210 NNS denotes loci
T13726 1211-1212 CD denotes 2
T13727 1213-1216 CC denotes and
T13728 1217-1218 CD denotes 7
T13729 1219-1228 RB denotes partially
T13723 1229-1236 VBP denotes overlap
T13730 1237-1241 IN denotes with
T13731 1242-1245 CD denotes two
T13733 1246-1255 NN denotes arthritis
T13735 1255-1256 HYPH denotes -
T13734 1256-1263 VBN denotes related
T13732 1264-1267 NNS denotes QTL
T13736 1268-1278 VBN denotes identified
T13737 1279-1281 IN denotes by
T13738 1282-1284 PRP denotes us
T13739 1285-1287 IN denotes in
T13740 1288-1291 DT denotes the
T13742 1292-1296 JJ denotes same
T13743 1297-1299 NN denotes F2
T13741 1300-1307 NN denotes progeny
T13744 1308-1309 -LRB- denotes [
T13745 1309-1311 CD denotes 10
T13746 1311-1312 -RRB- denotes ]
T13747 1312-1313 . denotes .
T13748 1313-1426 sentence denotes Locus 2 was located at the same genomic region as Cia27, a QTL controlling IgG2a antibody levels to collagen II.
T13749 1314-1319 NN denotes Locus
T13751 1320-1321 CD denotes 2
T13752 1322-1325 VBD denotes was
T13750 1326-1333 VBN denotes located
T13753 1334-1336 IN denotes at
T13754 1337-1340 DT denotes the
T13756 1341-1345 JJ denotes same
T13757 1346-1353 JJ denotes genomic
T13755 1354-1360 NN denotes region
T13758 1361-1363 IN denotes as
T13759 1364-1369 NN denotes Cia27
T13760 1369-1371 , denotes ,
T13761 1371-1372 DT denotes a
T13762 1373-1376 NN denotes QTL
T13763 1377-1388 VBG denotes controlling
T13764 1389-1394 NN denotes IgG2a
T13766 1395-1403 NN denotes antibody
T13765 1404-1410 NNS denotes levels
T13767 1411-1413 IN denotes to
T13768 1414-1422 NN denotes collagen
T13769 1423-1425 CD denotes II
T13770 1425-1426 . denotes .
T13771 1426-1617 sentence denotes Recently, we have refined this QTL into a 4.1 Mb genomic region and showed that a gene within this region regulates CIA severity by controlling the IgG2a antibody levels to collagen II [31].
T13772 1427-1435 RB denotes Recently
T13774 1435-1437 , denotes ,
T13775 1437-1439 PRP denotes we
T13776 1440-1444 VBP denotes have
T13773 1445-1452 VBN denotes refined
T13777 1453-1457 DT denotes this
T13778 1458-1461 NN denotes QTL
T13779 1462-1466 IN denotes into
T13780 1467-1468 DT denotes a
T13782 1469-1472 CD denotes 4.1
T13783 1473-1475 NN denotes Mb
T13784 1476-1483 JJ denotes genomic
T13781 1484-1490 NN denotes region
T13785 1491-1494 CC denotes and
T13786 1495-1501 VBD denotes showed
T13787 1502-1506 IN denotes that
T13789 1507-1508 DT denotes a
T13790 1509-1513 NN denotes gene
T13791 1514-1520 IN denotes within
T13792 1521-1525 DT denotes this
T13793 1526-1532 NN denotes region
T13788 1533-1542 VBZ denotes regulates
T13794 1543-1546 NN denotes CIA
T13795 1547-1555 NN denotes severity
T13796 1556-1558 IN denotes by
T13797 1559-1570 VBG denotes controlling
T13798 1571-1574 DT denotes the
T13800 1575-1580 NN denotes IgG2a
T13801 1581-1589 NN denotes antibody
T13799 1590-1596 NNS denotes levels
T13802 1597-1599 IN denotes to
T13803 1600-1608 NN denotes collagen
T13804 1609-1611 CD denotes II
T13805 1612-1613 -LRB- denotes [
T13806 1613-1615 CD denotes 31
T13807 1615-1616 -RRB- denotes ]
T13808 1616-1617 . denotes .
T13809 1617-1702 sentence denotes Locus 7 on chromosome 16 overlaps with Lp1, which controls lymphocyte proliferation.
T13810 1618-1623 NN denotes Locus
T13812 1624-1625 CD denotes 7
T13813 1626-1628 IN denotes on
T13814 1629-1639 NN denotes chromosome
T13815 1640-1642 CD denotes 16
T13811 1643-1651 VBZ denotes overlaps
T13816 1652-1656 IN denotes with
T13817 1657-1660 NN denotes Lp1
T13818 1660-1662 , denotes ,
T13819 1662-1667 WDT denotes which
T13820 1668-1676 VBZ denotes controls
T13821 1677-1687 NN denotes lymphocyte
T13822 1688-1701 NN denotes proliferation
T13823 1701-1702 . denotes .
T13824 1702-1831 sentence denotes Furthermore, according to our unpublished data, loci 8 on chromosome 17 controls lymphocyte adherence during development of CIA.
T13825 1703-1714 RB denotes Furthermore
T13827 1714-1716 , denotes ,
T13828 1716-1725 VBG denotes according
T13829 1726-1728 IN denotes to
T13830 1729-1732 PRP$ denotes our
T13832 1733-1744 JJ denotes unpublished
T13831 1745-1749 NNS denotes data
T13833 1749-1751 , denotes ,
T13834 1751-1755 NNS denotes loci
T13835 1756-1757 CD denotes 8
T13836 1758-1760 IN denotes on
T13837 1761-1771 NN denotes chromosome
T13838 1772-1774 CD denotes 17
T13826 1775-1783 VBZ denotes controls
T13839 1784-1794 NN denotes lymphocyte
T13840 1795-1804 NN denotes adherence
T13841 1805-1811 IN denotes during
T13842 1812-1823 NN denotes development
T13843 1824-1826 IN denotes of
T13844 1827-1830 NN denotes CIA
T13845 1830-1831 . denotes .
T13846 1831-1955 sentence denotes Therefore, the gene within the small-effect QTL could affect CIA severity through controlling arthritis-related phenotypes.
T13847 1832-1841 RB denotes Therefore
T13849 1841-1843 , denotes ,
T13850 1843-1846 DT denotes the
T13851 1847-1851 NN denotes gene
T13852 1852-1858 IN denotes within
T13853 1859-1862 DT denotes the
T13855 1863-1868 JJ denotes small
T13857 1868-1869 HYPH denotes -
T13856 1869-1875 NN denotes effect
T13854 1876-1879 NNS denotes QTL
T13858 1880-1885 MD denotes could
T13848 1886-1892 VB denotes affect
T13859 1893-1896 NN denotes CIA
T13860 1897-1905 NN denotes severity
T13861 1906-1913 IN denotes through
T13862 1914-1925 VBG denotes controlling
T13863 1926-1935 NN denotes arthritis
T13865 1935-1936 HYPH denotes -
T13864 1936-1943 VBN denotes related
T13866 1944-1954 NNS denotes phenotypes
T13867 1954-1955 . denotes .
T13868 1955-2092 sentence denotes Several studies have been carried out to detect gene expression during CIA, all of which used joints as the target tissue [15,16,21,22].
T13869 1956-1963 JJ denotes Several
T13870 1964-1971 NNS denotes studies
T13872 1972-1976 VBP denotes have
T13873 1977-1981 VBN denotes been
T13871 1982-1989 VBN denotes carried
T13874 1990-1993 RP denotes out
T13875 1994-1996 TO denotes to
T13876 1997-2003 VB denotes detect
T13877 2004-2008 NN denotes gene
T13878 2009-2019 NN denotes expression
T13879 2020-2026 IN denotes during
T13880 2027-2030 NN denotes CIA
T13881 2030-2032 , denotes ,
T13882 2032-2035 DT denotes all
T13884 2036-2038 IN denotes of
T13885 2039-2044 WDT denotes which
T13883 2045-2049 VBD denotes used
T13886 2050-2056 NNS denotes joints
T13887 2057-2059 IN denotes as
T13888 2060-2063 DT denotes the
T13890 2064-2070 NN denotes target
T13889 2071-2077 NN denotes tissue
T13891 2078-2079 -LRB- denotes [
T13893 2079-2081 CD denotes 15
T13894 2081-2082 , denotes ,
T13895 2082-2084 CD denotes 16
T13896 2084-2085 , denotes ,
T13897 2085-2087 CD denotes 21
T13898 2087-2088 , denotes ,
T13892 2088-2090 CD denotes 22
T13899 2090-2091 -RRB- denotes ]
T13900 2091-2092 . denotes .
T13901 2092-2168 sentence denotes This study, for the first time, detected gene expression in LNs during CIA.
T13902 2093-2097 DT denotes This
T13903 2098-2103 NN denotes study
T13905 2103-2105 , denotes ,
T13906 2105-2108 IN denotes for
T13907 2109-2112 DT denotes the
T13909 2113-2118 JJ denotes first
T13908 2119-2123 NN denotes time
T13910 2123-2125 , denotes ,
T13904 2125-2133 VBD denotes detected
T13911 2134-2138 NN denotes gene
T13912 2139-2149 NN denotes expression
T13913 2150-2152 IN denotes in
T13914 2153-2156 NNS denotes LNs
T13915 2157-2163 IN denotes during
T13916 2164-2167 NN denotes CIA
T13917 2167-2168 . denotes .
T13918 2168-2320 sentence denotes We present an extensive study of gene expression patterns in LNs of both genetically susceptible and resistant strains at four different phases of CIA.
T13919 2169-2171 PRP denotes We
T13920 2172-2179 VBP denotes present
T13921 2180-2182 DT denotes an
T13923 2183-2192 JJ denotes extensive
T13922 2193-2198 NN denotes study
T13924 2199-2201 IN denotes of
T13925 2202-2206 NN denotes gene
T13927 2207-2217 NN denotes expression
T13926 2218-2226 NNS denotes patterns
T13928 2227-2229 IN denotes in
T13929 2230-2233 NNS denotes LNs
T13930 2234-2236 IN denotes of
T13931 2237-2241 CC denotes both
T13933 2242-2253 RB denotes genetically
T13934 2254-2265 JJ denotes susceptible
T13935 2266-2269 CC denotes and
T13936 2270-2279 JJ denotes resistant
T13932 2280-2287 NNS denotes strains
T13937 2288-2290 IN denotes at
T13938 2291-2295 CD denotes four
T13940 2296-2305 JJ denotes different
T13939 2306-2312 NNS denotes phases
T13941 2313-2315 IN denotes of
T13942 2316-2319 NN denotes CIA
T13943 2319-2320 . denotes .
T13944 2320-2505 sentence denotes In both strains, differentially regulated genes were highly concentrated at the PI and CA phases, and only a small number of genes were differentially expressed in two or three phases.
T13945 2321-2323 IN denotes In
T13947 2324-2328 DT denotes both
T13948 2329-2336 NNS denotes strains
T13949 2336-2338 , denotes ,
T13950 2338-2352 RB denotes differentially
T13951 2353-2362 VBN denotes regulated
T13952 2363-2368 NNS denotes genes
T13946 2369-2373 VBD denotes were
T13953 2374-2380 RB denotes highly
T13954 2381-2393 JJ denotes concentrated
T13955 2394-2396 IN denotes at
T13956 2397-2400 DT denotes the
T13958 2401-2403 NN denotes PI
T13959 2404-2407 CC denotes and
T13960 2408-2410 NN denotes CA
T13957 2411-2417 NNS denotes phases
T13961 2417-2419 , denotes ,
T13962 2419-2422 CC denotes and
T13963 2423-2427 RB denotes only
T13965 2428-2429 DT denotes a
T13966 2430-2435 JJ denotes small
T13964 2436-2442 NN denotes number
T13968 2443-2445 IN denotes of
T13969 2446-2451 NNS denotes genes
T13970 2452-2456 VBD denotes were
T13971 2457-2471 RB denotes differentially
T13967 2472-2481 VBN denotes expressed
T13972 2482-2484 IN denotes in
T13973 2485-2488 CD denotes two
T13975 2489-2491 CC denotes or
T13976 2492-2497 CD denotes three
T13974 2498-2504 NNS denotes phases
T13977 2504-2505 . denotes .
T13978 2505-2667 sentence denotes This indicates that biological responses in LNs were stronger in the PI and CA phases than in the OA phase, and the responses at different phases were different.
T13979 2506-2510 DT denotes This
T13980 2511-2520 VBZ denotes indicates
T13981 2521-2525 IN denotes that
T13983 2526-2536 JJ denotes biological
T13984 2537-2546 NNS denotes responses
T13985 2547-2549 IN denotes in
T13986 2550-2553 NNS denotes LNs
T13982 2554-2558 VBD denotes were
T13987 2559-2567 JJR denotes stronger
T13988 2568-2570 IN denotes in
T13989 2571-2574 DT denotes the
T13991 2575-2577 NN denotes PI
T13992 2578-2581 CC denotes and
T13993 2582-2584 NN denotes CA
T13990 2585-2591 NNS denotes phases
T13994 2592-2596 IN denotes than
T13995 2597-2599 IN denotes in
T13996 2600-2603 DT denotes the
T13998 2604-2606 NN denotes OA
T13997 2607-2612 NN denotes phase
T13999 2612-2614 , denotes ,
T14000 2614-2617 CC denotes and
T14001 2618-2621 DT denotes the
T14002 2622-2631 NNS denotes responses
T14004 2632-2634 IN denotes at
T14005 2635-2644 JJ denotes different
T14006 2645-2651 NNS denotes phases
T14003 2652-2656 VBD denotes were
T14007 2657-2666 JJ denotes different
T14008 2666-2667 . denotes .
T14009 2667-2804 sentence denotes When comparing the susceptible to the resistant strain, the biggest difference was found in one cluster of genes (cluster IV, Figure 2).
T14010 2668-2672 WRB denotes When
T14011 2673-2682 VBG denotes comparing
T14013 2683-2686 DT denotes the
T14014 2687-2698 JJ denotes susceptible
T14015 2699-2701 IN denotes to
T14016 2702-2705 DT denotes the
T14017 2706-2715 JJ denotes resistant
T14018 2716-2722 NN denotes strain
T14019 2722-2724 , denotes ,
T14020 2724-2727 DT denotes the
T14022 2728-2735 JJS denotes biggest
T14021 2736-2746 NN denotes difference
T14023 2747-2750 VBD denotes was
T14012 2751-2756 VBN denotes found
T14024 2757-2759 IN denotes in
T14025 2760-2763 CD denotes one
T14026 2764-2771 NN denotes cluster
T14027 2772-2774 IN denotes of
T14028 2775-2780 NNS denotes genes
T14029 2781-2782 -LRB- denotes (
T14030 2782-2789 NN denotes cluster
T14031 2790-2792 CD denotes IV
T14032 2792-2794 , denotes ,
T14033 2794-2800 NN denotes Figure
T14034 2801-2802 CD denotes 2
T14035 2802-2803 -RRB- denotes )
T14036 2803-2804 . denotes .
T14037 2804-2959 sentence denotes These genes had a higher expression in DBA/1 than in FVB/N at the early phases of CIA (NC, PI and OA) and the opposite expression pattern in the CA phase.
T14038 2805-2810 DT denotes These
T14039 2811-2816 NNS denotes genes
T14040 2817-2820 VBD denotes had
T14041 2821-2822 DT denotes a
T14043 2823-2829 JJR denotes higher
T14042 2830-2840 NN denotes expression
T14044 2841-2843 IN denotes in
T14045 2844-2847 NN denotes DBA
T14046 2847-2848 HYPH denotes /
T14047 2848-2849 CD denotes 1
T14048 2850-2854 IN denotes than
T14049 2855-2857 IN denotes in
T14050 2858-2861 NN denotes FVB
T14052 2861-2862 HYPH denotes /
T14051 2862-2863 NN denotes N
T14053 2864-2866 IN denotes at
T14054 2867-2870 DT denotes the
T14056 2871-2876 JJ denotes early
T14055 2877-2883 NNS denotes phases
T14057 2884-2886 IN denotes of
T14058 2887-2890 NN denotes CIA
T14059 2891-2892 -LRB- denotes (
T14060 2892-2894 NN denotes NC
T14061 2894-2896 , denotes ,
T14062 2896-2898 NN denotes PI
T14063 2899-2902 CC denotes and
T14064 2903-2905 NN denotes OA
T14065 2905-2906 -RRB- denotes )
T14066 2907-2910 CC denotes and
T14067 2911-2914 DT denotes the
T14069 2915-2923 JJ denotes opposite
T14070 2924-2934 NN denotes expression
T14068 2935-2942 NN denotes pattern
T14071 2943-2945 IN denotes in
T14072 2946-2949 DT denotes the
T14074 2950-2952 NN denotes CA
T14073 2953-2958 NN denotes phase
T14075 2958-2959 . denotes .
T14076 2959-3164 sentence denotes GO term classification revealed that these genes were related to lymphocyte proliferation and activation, suggesting that lymphocytes in the DBA/1 strain are more activated than those in the FVB/N strain.
T14077 2960-2962 NN denotes GO
T14079 2963-2967 NN denotes term
T14078 2968-2982 NN denotes classification
T14080 2983-2991 VBD denotes revealed
T14081 2992-2996 IN denotes that
T14083 2997-3002 DT denotes these
T14084 3003-3008 NNS denotes genes
T14085 3009-3013 VBD denotes were
T14082 3014-3021 VBN denotes related
T14086 3022-3024 IN denotes to
T14087 3025-3035 NN denotes lymphocyte
T14088 3036-3049 NN denotes proliferation
T14089 3050-3053 CC denotes and
T14090 3054-3064 NN denotes activation
T14091 3064-3066 , denotes ,
T14092 3066-3076 VBG denotes suggesting
T14093 3077-3081 IN denotes that
T14095 3082-3093 NNS denotes lymphocytes
T14096 3094-3096 IN denotes in
T14097 3097-3100 DT denotes the
T14099 3101-3104 NN denotes DBA
T14100 3104-3105 HYPH denotes /
T14101 3105-3106 CD denotes 1
T14098 3107-3113 NN denotes strain
T14094 3114-3117 VBP denotes are
T14102 3118-3122 RBR denotes more
T14103 3123-3132 JJ denotes activated
T14104 3133-3137 IN denotes than
T14105 3138-3143 DT denotes those
T14106 3144-3146 IN denotes in
T14107 3147-3150 DT denotes the
T14109 3151-3154 NN denotes FVB
T14111 3154-3155 HYPH denotes /
T14110 3155-3156 NN denotes N
T14108 3157-3163 NN denotes strain
T14112 3163-3164 . denotes .
T14113 3164-3305 sentence denotes However, this difference is not CIA specific because the expression difference between the two strains existed in mice without immunisation.
T14114 3165-3172 RB denotes However
T14116 3172-3174 , denotes ,
T14117 3174-3178 DT denotes this
T14118 3179-3189 NN denotes difference
T14115 3190-3192 VBZ denotes is
T14119 3193-3196 RB denotes not
T14120 3197-3200 NN denotes CIA
T14121 3201-3209 JJ denotes specific
T14122 3210-3217 IN denotes because
T14124 3218-3221 DT denotes the
T14126 3222-3232 NN denotes expression
T14125 3233-3243 NN denotes difference
T14127 3244-3251 IN denotes between
T14128 3252-3255 DT denotes the
T14130 3256-3259 CD denotes two
T14129 3260-3267 NNS denotes strains
T14123 3268-3275 VBD denotes existed
T14131 3276-3278 IN denotes in
T14132 3279-3283 NNS denotes mice
T14133 3284-3291 IN denotes without
T14134 3292-3304 NN denotes immunisation
T14135 3304-3305 . denotes .
T14136 3305-3438 sentence denotes Additionally, some genes related to the immune response were upregulated in the DBA/1 strain but not in the FVB/N strain during CIA.
T14137 3306-3318 RB denotes Additionally
T14139 3318-3320 , denotes ,
T14140 3320-3324 DT denotes some
T14141 3325-3330 NNS denotes genes
T14142 3331-3338 VBN denotes related
T14143 3339-3341 IN denotes to
T14144 3342-3345 DT denotes the
T14146 3346-3352 JJ denotes immune
T14145 3353-3361 NN denotes response
T14147 3362-3366 VBD denotes were
T14138 3367-3378 VBN denotes upregulated
T14148 3379-3381 IN denotes in
T14149 3382-3385 DT denotes the
T14151 3386-3389 NN denotes DBA
T14152 3389-3390 HYPH denotes /
T14153 3390-3391 CD denotes 1
T14150 3392-3398 NN denotes strain
T14154 3399-3402 CC denotes but
T14155 3403-3406 RB denotes not
T14156 3407-3409 IN denotes in
T14157 3410-3413 DT denotes the
T14159 3414-3417 NN denotes FVB
T14161 3417-3418 HYPH denotes /
T14160 3418-3419 NN denotes N
T14158 3420-3426 NN denotes strain
T14162 3427-3433 IN denotes during
T14163 3434-3437 NN denotes CIA
T14164 3437-3438 . denotes .
T14165 3438-3669 sentence denotes These differences could explain why a higher antibody response to collagen II occurred in the DBA/1 strain compared to the FVB/N strain, and might partially explain the difference of the susceptibility to CIA between both strains.
T14166 3439-3444 DT denotes These
T14167 3445-3456 NNS denotes differences
T14169 3457-3462 MD denotes could
T14168 3463-3470 VB denotes explain
T14170 3471-3474 WRB denotes why
T14172 3475-3476 DT denotes a
T14174 3477-3483 JJR denotes higher
T14175 3484-3492 NN denotes antibody
T14173 3493-3501 NN denotes response
T14176 3502-3504 IN denotes to
T14177 3505-3513 NN denotes collagen
T14178 3514-3516 CD denotes II
T14171 3517-3525 VBD denotes occurred
T14179 3526-3528 IN denotes in
T14180 3529-3532 DT denotes the
T14182 3533-3536 NN denotes DBA
T14183 3536-3537 HYPH denotes /
T14184 3537-3538 CD denotes 1
T14181 3539-3545 NN denotes strain
T14185 3546-3554 VBN denotes compared
T14186 3555-3557 IN denotes to
T14187 3558-3561 DT denotes the
T14189 3562-3565 NN denotes FVB
T14191 3565-3566 HYPH denotes /
T14190 3566-3567 NN denotes N
T14188 3568-3574 NN denotes strain
T14192 3574-3576 , denotes ,
T14193 3576-3579 CC denotes and
T14194 3580-3585 MD denotes might
T14196 3586-3595 RB denotes partially
T14195 3596-3603 VB denotes explain
T14197 3604-3607 DT denotes the
T14198 3608-3618 NN denotes difference
T14199 3619-3621 IN denotes of
T14200 3622-3625 DT denotes the
T14201 3626-3640 NN denotes susceptibility
T14202 3641-3643 IN denotes to
T14203 3644-3647 NN denotes CIA
T14204 3648-3655 IN denotes between
T14205 3656-3660 DT denotes both
T14206 3661-3668 NNS denotes strains
T14207 3668-3669 . denotes .
T14208 3669-3853 sentence denotes Twenty-one genes were identified as potential candidate genes for six of the eight small-effect QTL according to their gene expression patterns during CIA and their genomic locations.
T14209 3670-3676 CD denotes Twenty
T14211 3676-3677 HYPH denotes -
T14210 3677-3680 CD denotes one
T14212 3681-3686 NNS denotes genes
T14214 3687-3691 VBD denotes were
T14213 3692-3702 VBN denotes identified
T14215 3703-3705 IN denotes as
T14216 3706-3715 JJ denotes potential
T14218 3716-3725 NN denotes candidate
T14217 3726-3731 NNS denotes genes
T14219 3732-3735 IN denotes for
T14220 3736-3739 CD denotes six
T14222 3740-3742 IN denotes of
T14223 3743-3746 DT denotes the
T14221 3747-3752 CD denotes eight
T14225 3753-3758 JJ denotes small
T14227 3758-3759 HYPH denotes -
T14226 3759-3765 NN denotes effect
T14224 3766-3769 NNS denotes QTL
T14228 3770-3779 VBG denotes according
T14229 3780-3782 IN denotes to
T14230 3783-3788 PRP$ denotes their
T14232 3789-3793 NN denotes gene
T14233 3794-3804 NN denotes expression
T14231 3805-3813 NNS denotes patterns
T14234 3814-3820 IN denotes during
T14235 3821-3824 NN denotes CIA
T14236 3825-3828 CC denotes and
T14237 3829-3834 PRP$ denotes their
T14239 3835-3842 JJ denotes genomic
T14238 3843-3852 NNS denotes locations
T14240 3852-3853 . denotes .
T14241 3853-4046 sentence denotes No candidate genes were located in QTL 4 and 7, suggesting that QTG polymorphisms of the susceptibility genes inside these two QTL might not affect the phenotype by regulating gene expression.
T14242 3854-3856 DT denotes No
T14244 3857-3866 NN denotes candidate
T14243 3867-3872 NNS denotes genes
T14246 3873-3877 VBD denotes were
T14245 3878-3885 VBN denotes located
T14247 3886-3888 IN denotes in
T14248 3889-3892 NNS denotes QTL
T14249 3893-3894 CD denotes 4
T14250 3895-3898 CC denotes and
T14251 3899-3900 CD denotes 7
T14252 3900-3902 , denotes ,
T14253 3902-3912 VBG denotes suggesting
T14254 3913-3917 IN denotes that
T14256 3918-3921 NN denotes QTG
T14257 3922-3935 NNS denotes polymorphisms
T14258 3936-3938 IN denotes of
T14259 3939-3942 DT denotes the
T14261 3943-3957 NN denotes susceptibility
T14260 3958-3963 NNS denotes genes
T14262 3964-3970 IN denotes inside
T14263 3971-3976 DT denotes these
T14265 3977-3980 CD denotes two
T14264 3981-3984 NNS denotes QTL
T14266 3985-3990 MD denotes might
T14267 3991-3994 RB denotes not
T14255 3995-4001 VB denotes affect
T14268 4002-4005 DT denotes the
T14269 4006-4015 NN denotes phenotype
T14270 4016-4018 IN denotes by
T14271 4019-4029 VBG denotes regulating
T14272 4030-4034 NN denotes gene
T14273 4035-4045 NN denotes expression
T14274 4045-4046 . denotes .
T14275 4046-4119 sentence denotes Two of the 21 candidate genes were reported to be involved in arthritis.
T14276 4047-4050 CD denotes Two
T14278 4051-4053 IN denotes of
T14279 4054-4057 DT denotes the
T14277 4058-4060 CD denotes 21
T14281 4061-4070 NN denotes candidate
T14280 4071-4076 NNS denotes genes
T14283 4077-4081 VBD denotes were
T14282 4082-4090 VBN denotes reported
T14284 4091-4093 TO denotes to
T14286 4094-4096 VB denotes be
T14285 4097-4105 VBN denotes involved
T14287 4106-4108 IN denotes in
T14288 4109-4118 NN denotes arthritis
T14289 4118-4119 . denotes .
T14290 4119-4337 sentence denotes Mapk14, a candidate gene for locus 8 and also called p38 mitogen-activated protein kinase (MAPK) alpha, regulates the production of arthritis-essential cytokines, such as tumour necrosis factor and interleukin-1 [32].
T14291 4120-4126 NN denotes Mapk14
T14293 4126-4128 , denotes ,
T14294 4128-4129 DT denotes a
T14296 4130-4139 NN denotes candidate
T14295 4140-4144 NN denotes gene
T14297 4145-4148 IN denotes for
T14298 4149-4154 NN denotes locus
T14299 4155-4156 CD denotes 8
T14300 4157-4160 CC denotes and
T14301 4161-4165 RB denotes also
T14302 4166-4172 VBN denotes called
T14303 4173-4176 NN denotes p38
T14305 4177-4184 NN denotes mitogen
T14307 4184-4185 HYPH denotes -
T14306 4185-4194 VBN denotes activated
T14308 4195-4202 NN denotes protein
T14304 4203-4209 NN denotes kinase
T14310 4210-4211 -LRB- denotes (
T14311 4211-4215 NN denotes MAPK
T14312 4215-4216 -RRB- denotes )
T14309 4217-4222 NN denotes alpha
T14313 4222-4224 , denotes ,
T14292 4224-4233 VBZ denotes regulates
T14314 4234-4237 DT denotes the
T14315 4238-4248 NN denotes production
T14316 4249-4251 IN denotes of
T14317 4252-4261 NN denotes arthritis
T14319 4261-4262 HYPH denotes -
T14318 4262-4271 JJ denotes essential
T14320 4272-4281 NNS denotes cytokines
T14321 4281-4283 , denotes ,
T14322 4283-4287 JJ denotes such
T14323 4288-4290 IN denotes as
T14324 4291-4297 NN denotes tumour
T14326 4298-4306 NN denotes necrosis
T14325 4307-4313 NN denotes factor
T14327 4314-4317 CC denotes and
T14328 4318-4329 NN denotes interleukin
T14329 4329-4330 HYPH denotes -
T14330 4330-4331 CD denotes 1
T14331 4332-4333 -LRB- denotes [
T14332 4333-4335 CD denotes 32
T14333 4335-4336 -RRB- denotes ]
T14334 4336-4337 . denotes .
T14335 4337-4472 sentence denotes Moreover, inhibitors of p38 MAPK could attenuate CIA in rats [33], and p38 MAPK is becoming a potential therapeutic target in RA [32].
T14336 4338-4346 RB denotes Moreover
T14338 4346-4348 , denotes ,
T14339 4348-4358 NNS denotes inhibitors
T14340 4359-4361 IN denotes of
T14341 4362-4365 NN denotes p38
T14342 4366-4370 NN denotes MAPK
T14343 4371-4376 MD denotes could
T14337 4377-4386 VB denotes attenuate
T14344 4387-4390 NN denotes CIA
T14345 4391-4393 IN denotes in
T14346 4394-4398 NNS denotes rats
T14347 4399-4400 -LRB- denotes [
T14348 4400-4402 CD denotes 33
T14349 4402-4403 -RRB- denotes ]
T14350 4403-4405 , denotes ,
T14351 4405-4408 CC denotes and
T14352 4409-4412 NN denotes p38
T14353 4413-4417 NN denotes MAPK
T14355 4418-4420 VBZ denotes is
T14354 4421-4429 VBG denotes becoming
T14356 4430-4431 DT denotes a
T14358 4432-4441 JJ denotes potential
T14359 4442-4453 JJ denotes therapeutic
T14357 4454-4460 NN denotes target
T14360 4461-4463 IN denotes in
T14361 4464-4466 NN denotes RA
T14362 4467-4468 -LRB- denotes [
T14363 4468-4470 CD denotes 32
T14364 4470-4471 -RRB- denotes ]
T14365 4471-4472 . denotes .
T14366 4472-4585 sentence denotes Stat5a, a candidate gene for loci 6, is an essential molecule for lymphoid development and differentiation [34].
T14367 4473-4479 NN denotes Stat5a
T14369 4479-4481 , denotes ,
T14370 4481-4482 DT denotes a
T14372 4483-4492 NN denotes candidate
T14371 4493-4497 NN denotes gene
T14373 4498-4501 IN denotes for
T14374 4502-4506 NNS denotes loci
T14375 4507-4508 CD denotes 6
T14376 4508-4510 , denotes ,
T14368 4510-4512 VBZ denotes is
T14377 4513-4515 DT denotes an
T14379 4516-4525 JJ denotes essential
T14378 4526-4534 NN denotes molecule
T14380 4535-4538 IN denotes for
T14381 4539-4547 NN denotes lymphoid
T14382 4548-4559 NN denotes development
T14383 4560-4563 CC denotes and
T14384 4564-4579 NN denotes differentiation
T14385 4580-4581 -LRB- denotes [
T14386 4581-4583 CD denotes 34
T14387 4583-4584 -RRB- denotes ]
T14388 4584-4585 . denotes .
T14389 4585-4693 sentence denotes Stat5a-deficient mice were reported to lose tolerance, resulting in the development of autoimmune diseases.
T14390 4586-4592 NN denotes Stat5a
T14392 4592-4593 HYPH denotes -
T14391 4593-4602 JJ denotes deficient
T14393 4603-4607 NNS denotes mice
T14395 4608-4612 VBD denotes were
T14394 4613-4621 VBN denotes reported
T14396 4622-4624 TO denotes to
T14397 4625-4629 VB denotes lose
T14398 4630-4639 NN denotes tolerance
T14399 4639-4641 , denotes ,
T14400 4641-4650 VBG denotes resulting
T14401 4651-4653 IN denotes in
T14402 4654-4657 DT denotes the
T14403 4658-4669 NN denotes development
T14404 4670-4672 IN denotes of
T14405 4673-4683 JJ denotes autoimmune
T14406 4684-4692 NNS denotes diseases
T14407 4692-4693 . denotes .
T14408 4693-4812 sentence denotes Stat5a is suggested to contribute to tolerance through maintenance of the CD4+CD25+ regulatory T cell population [35].
T14409 4694-4700 NN denotes Stat5a
T14411 4701-4703 VBZ denotes is
T14410 4704-4713 VBN denotes suggested
T14412 4714-4716 TO denotes to
T14413 4717-4727 VB denotes contribute
T14414 4728-4730 IN denotes to
T14415 4731-4740 NN denotes tolerance
T14416 4741-4748 IN denotes through
T14417 4749-4760 NN denotes maintenance
T14418 4761-4763 IN denotes of
T14419 4764-4767 DT denotes the
T14421 4768-4777 NN denotes CD4+CD25+
T14422 4778-4788 JJ denotes regulatory
T14423 4789-4790 NN denotes T
T14424 4791-4795 NN denotes cell
T14420 4796-4806 NN denotes population
T14425 4807-4808 -LRB- denotes [
T14426 4808-4810 CD denotes 35
T14427 4810-4811 -RRB- denotes ]
T14428 4811-4812 . denotes .
T14429 4812-4935 sentence denotes Therefore, we have presented a strategy to identify small-effect QTL and search for potential candidate genes within them.
T14430 4813-4822 RB denotes Therefore
T14432 4822-4824 , denotes ,
T14433 4824-4826 PRP denotes we
T14434 4827-4831 VBP denotes have
T14431 4832-4841 VBN denotes presented
T14435 4842-4843 DT denotes a
T14436 4844-4852 NN denotes strategy
T14437 4853-4855 TO denotes to
T14438 4856-4864 VB denotes identify
T14439 4865-4870 JJ denotes small
T14441 4870-4871 HYPH denotes -
T14440 4871-4877 NN denotes effect
T14442 4878-4881 NNS denotes QTL
T14443 4882-4885 CC denotes and
T14444 4886-4892 VB denotes search
T14445 4893-4896 IN denotes for
T14446 4897-4906 JJ denotes potential
T14448 4907-4916 NN denotes candidate
T14447 4917-4922 NNS denotes genes
T14449 4923-4929 IN denotes within
T14450 4930-4934 PRP denotes them
T14451 4934-4935 . denotes .
T14452 4935-5077 sentence denotes However, it is noteworthy that the low statistical threshold and small number of animals per group could lead to some false positive results.
T14453 4936-4943 RB denotes However
T14455 4943-4945 , denotes ,
T14456 4945-4947 PRP denotes it
T14454 4948-4950 VBZ denotes is
T14457 4951-4961 JJ denotes noteworthy
T14458 4962-4966 IN denotes that
T14460 4967-4970 DT denotes the
T14462 4971-4974 JJ denotes low
T14463 4975-4986 JJ denotes statistical
T14461 4987-4996 NN denotes threshold
T14464 4997-5000 CC denotes and
T14465 5001-5006 JJ denotes small
T14466 5007-5013 NN denotes number
T14467 5014-5016 IN denotes of
T14468 5017-5024 NNS denotes animals
T14469 5025-5028 IN denotes per
T14470 5029-5034 NN denotes group
T14471 5035-5040 MD denotes could
T14459 5041-5045 VB denotes lead
T14472 5046-5048 IN denotes to
T14473 5049-5053 DT denotes some
T14475 5054-5059 JJ denotes false
T14476 5060-5068 JJ denotes positive
T14474 5069-5076 NNS denotes results
T14477 5076-5077 . denotes .
T14478 5077-5214 sentence denotes On the genome level, some of the eight small-effect QTL identified using a very low threshold value (P < 0.05) could be false positives.
T14479 5078-5080 IN denotes On
T14481 5081-5084 DT denotes the
T14483 5085-5091 NN denotes genome
T14482 5092-5097 NN denotes level
T14484 5097-5099 , denotes ,
T14485 5099-5103 DT denotes some
T14486 5104-5106 IN denotes of
T14487 5107-5110 DT denotes the
T14489 5111-5116 CD denotes eight
T14490 5117-5122 JJ denotes small
T14492 5122-5123 HYPH denotes -
T14491 5123-5129 NN denotes effect
T14488 5130-5133 NNS denotes QTL
T14493 5134-5144 VBN denotes identified
T14494 5145-5150 VBG denotes using
T14495 5151-5152 DT denotes a
T14497 5153-5157 RB denotes very
T14498 5158-5161 JJ denotes low
T14499 5162-5171 NN denotes threshold
T14496 5172-5177 NN denotes value
T14500 5178-5179 -LRB- denotes (
T14502 5179-5180 NN denotes P
T14503 5181-5182 SYM denotes <
T14501 5183-5187 CD denotes 0.05
T14504 5187-5188 -RRB- denotes )
T14505 5189-5194 MD denotes could
T14480 5195-5197 VB denotes be
T14506 5198-5203 JJ denotes false
T14507 5204-5213 NNS denotes positives
T14508 5213-5214 . denotes .
T14509 5214-5336 sentence denotes For example, locus 4 was identified with a low P value and does not overlap with any previously identified arthritis QTL.
T14510 5215-5218 IN denotes For
T14512 5219-5226 NN denotes example
T14513 5226-5228 , denotes ,
T14514 5228-5233 NN denotes locus
T14515 5234-5235 CD denotes 4
T14516 5236-5239 VBD denotes was
T14511 5240-5250 VBN denotes identified
T14517 5251-5255 IN denotes with
T14518 5256-5257 DT denotes a
T14520 5258-5261 JJ denotes low
T14521 5262-5263 NN denotes P
T14519 5264-5269 NN denotes value
T14522 5270-5273 CC denotes and
T14523 5274-5278 VBZ denotes does
T14525 5279-5282 RB denotes not
T14524 5283-5290 VB denotes overlap
T14526 5291-5295 IN denotes with
T14527 5296-5299 DT denotes any
T14529 5300-5310 RB denotes previously
T14530 5311-5321 VBN denotes identified
T14531 5322-5331 NN denotes arthritis
T14528 5332-5335 NNS denotes QTL
T14532 5335-5336 . denotes .
T14533 5336-5531 sentence denotes On the transcriptome level, the small number of animals per group and the low threshold used to detect gene expression could also result in false positives in the differentially expressed genes.
T14534 5337-5339 IN denotes On
T14536 5340-5343 DT denotes the
T14538 5344-5357 NN denotes transcriptome
T14537 5358-5363 NN denotes level
T14539 5363-5365 , denotes ,
T14540 5365-5368 DT denotes the
T14542 5369-5374 JJ denotes small
T14541 5375-5381 NN denotes number
T14543 5382-5384 IN denotes of
T14544 5385-5392 NNS denotes animals
T14545 5393-5396 IN denotes per
T14546 5397-5402 NN denotes group
T14547 5403-5406 CC denotes and
T14548 5407-5410 DT denotes the
T14550 5411-5414 JJ denotes low
T14549 5415-5424 NN denotes threshold
T14551 5425-5429 VBN denotes used
T14552 5430-5432 TO denotes to
T14553 5433-5439 VB denotes detect
T14554 5440-5444 NN denotes gene
T14555 5445-5455 NN denotes expression
T14556 5456-5461 MD denotes could
T14557 5462-5466 RB denotes also
T14535 5467-5473 VB denotes result
T14558 5474-5476 IN denotes in
T14559 5477-5482 JJ denotes false
T14560 5483-5492 NNS denotes positives
T14561 5493-5495 IN denotes in
T14562 5496-5499 DT denotes the
T14564 5500-5514 RB denotes differentially
T14565 5515-5524 VBN denotes expressed
T14563 5525-5530 NNS denotes genes
T14566 5530-5531 . denotes .
T14567 5531-5677 sentence denotes Furthermore, the differential expression of a gene could result not only from allele difference between two strains, but also from other factors.
T14568 5532-5543 RB denotes Furthermore
T14570 5543-5545 , denotes ,
T14571 5545-5548 DT denotes the
T14573 5549-5561 JJ denotes differential
T14572 5562-5572 NN denotes expression
T14574 5573-5575 IN denotes of
T14575 5576-5577 DT denotes a
T14576 5578-5582 NN denotes gene
T14577 5583-5588 MD denotes could
T14569 5589-5595 VB denotes result
T14578 5596-5599 RB denotes not
T14580 5600-5604 RB denotes only
T14579 5605-5609 IN denotes from
T14581 5610-5616 NN denotes allele
T14582 5617-5627 NN denotes difference
T14583 5628-5635 IN denotes between
T14584 5636-5639 CD denotes two
T14585 5640-5647 NNS denotes strains
T14586 5647-5649 , denotes ,
T14587 5649-5652 CC denotes but
T14588 5653-5657 RB denotes also
T14589 5658-5662 IN denotes from
T14590 5663-5668 JJ denotes other
T14591 5669-5676 NNS denotes factors
T14592 5676-5677 . denotes .
T14593 5677-5740 sentence denotes Therefore, our findings should be confirmed in future studies.
T14594 5678-5687 RB denotes Therefore
T14596 5687-5689 , denotes ,
T14597 5689-5692 PRP$ denotes our
T14598 5693-5701 NNS denotes findings
T14599 5702-5708 MD denotes should
T14600 5709-5711 VB denotes be
T14595 5712-5721 VBN denotes confirmed
T14601 5722-5724 IN denotes in
T14602 5725-5731 JJ denotes future
T14603 5732-5739 NNS denotes studies
T14604 5739-5740 . denotes .
R3525 T13481 T13482 prep In,attempted
R3526 T13483 T13484 det this,study
R3527 T13484 T13481 pobj study,In
R3528 T13485 T13482 punct ", ",attempted
R3529 T13486 T13482 nsubj we,attempted
R3530 T13487 T13482 prep for,attempted
R3531 T13488 T13489 det the,time
R3532 T13489 T13487 pobj time,for
R3533 T13490 T13489 amod first,time
R3534 T13491 T13492 aux to,identify
R3535 T13492 T13482 xcomp identify,attempted
R3536 T13493 T13494 amod small,effect
R3537 T13494 T13496 compound effect,QTL
R3538 T13495 T13494 punct -,effect
R3539 T13496 T13492 dobj QTL,identify
R3540 T13497 T13492 prep in,identify
R3541 T13498 T13499 det an,progeny
R3542 T13499 T13497 pobj progeny,in
R3543 T13500 T13499 compound F2,progeny
R3544 T13501 T13482 punct .,attempted
R3545 T13503 T13504 amod Small,effect
R3546 T13504 T13506 compound effect,QTL
R3547 T13505 T13504 punct -,effect
R3548 T13506 T13507 nsubjpass QTL,defined
R3549 T13508 T13507 auxpass are,defined
R3550 T13509 T13507 prep as,defined
R3551 T13510 T13509 pobj those,as
R3552 T13511 T13510 acl reaching,those
R3553 T13512 T13513 det the,value
R3554 T13513 T13511 dobj value,reaching
R3555 T13514 T13513 compound threshold,value
R3556 T13515 T13513 prep of,value
R3557 T13516 T13517 nsubj P,0.05
R3558 T13517 T13515 pcomp 0.05,of
R3559 T13518 T13517 punct =,0.05
R3560 T13519 T13507 cc but,defined
R3561 T13520 T13521 nsubj that,reach
R3562 T13521 T13507 conj reach,defined
R3563 T13522 T13521 aux did,reach
R3564 T13523 T13521 neg not,reach
R3565 T13524 T13525 det the,value
R3566 T13525 T13521 dobj value,reach
R3567 T13526 T13527 amod significant,threshold
R3568 T13527 T13525 compound threshold,value
R3569 T13528 T13525 acl suggested,value
R3570 T13529 T13528 agent by,suggested
R3571 T13530 T13529 pobj Lander,by
R3572 T13531 T13530 cc and,Lander
R3573 T13532 T13530 conj Botstein,Lander
R3574 T13533 T13534 punct [,26
R3575 T13534 T13528 parataxis 26,suggested
R3576 T13535 T13534 punct ],26
R3577 T13536 T13521 punct .,reach
R3578 T13538 T13539 mark Although,significant
R3579 T13539 T13541 advcl significant,is
R3580 T13540 T13539 neg not,significant
R3581 T13542 T13541 punct ", ",is
R3582 T13543 T13541 expl there,is
R3583 T13544 T13541 attr evidence,is
R3584 T13545 T13546 mark that,contain
R3585 T13546 T13544 acl contain,evidence
R3586 T13547 T13546 nsubj most,contain
R3587 T13548 T13547 prep of,most
R3588 T13549 T13550 det the,QTL
R3589 T13550 T13548 pobj QTL,of
R3590 T13551 T13550 nummod eight,QTL
R3591 T13552 T13553 amod small,effect
R3592 T13553 T13550 compound effect,QTL
R3593 T13554 T13553 punct -,effect
R3594 T13555 T13546 advmod likely,contain
R3595 T13556 T13557 compound susceptibility,genes
R3596 T13557 T13546 dobj genes,contain
R3597 T13558 T13557 prep for,genes
R3598 T13559 T13558 pobj CIA,for
R3599 T13560 T13541 punct .,is
R3600 T13562 T13563 advmod First,performed
R3601 T13564 T13563 punct ", ",performed
R3602 T13565 T13563 nsubj we,performed
R3603 T13566 T13567 det the,analysis
R3604 T13567 T13563 dobj analysis,performed
R3605 T13568 T13567 compound linkage,analysis
R3606 T13569 T13563 prep in,performed
R3607 T13570 T13571 nummod three,datasets
R3608 T13571 T13569 pobj datasets,in
R3609 T13572 T13571 punct ", ",datasets
R3610 T13573 T13571 prep including,datasets
R3611 T13574 T13575 det all,progeny
R3612 T13575 T13573 pobj progeny,including
R3613 T13576 T13575 nummod 290,progeny
R3614 T13577 T13575 compound F,progeny
R3615 T13578 T13575 punct ", ",progeny
R3616 T13579 T13580 nummod 76,progeny
R3617 T13580 T13575 conj progeny,progeny
R3618 T13581 T13580 nmod C5+,progeny
R3619 T13582 T13581 punct /,C5+
R3620 T13583 T13581 punct +,C5+
R3621 T13584 T13580 compound F2,progeny
R3622 T13585 T13580 cc and,progeny
R3623 T13586 T13587 nummod 133,progeny
R3624 T13587 T13580 conj progeny,progeny
R3625 T13588 T13587 nmod C5+,progeny
R3626 T13589 T13588 punct /,C5+
R3627 T13590 T13588 punct -,C5+
R3628 T13591 T13587 compound F2,progeny
R3629 T13592 T13563 punct .,performed
R3630 T13594 T13595 quantmod Five,eight
R3631 T13595 T13598 nummod eight,QTL
R3632 T13596 T13595 quantmod of,eight
R3633 T13597 T13595 quantmod the,eight
R3634 T13598 T13602 nsubjpass QTL,identified
R3635 T13599 T13600 amod small,effect
R3636 T13600 T13598 compound effect,QTL
R3637 T13601 T13600 punct -,effect
R3638 T13603 T13602 auxpass were,identified
R3639 T13604 T13602 prep in,identified
R3640 T13605 T13606 advmod at,two
R3641 T13606 T13608 nummod two,datasets
R3642 T13607 T13606 advmod least,two
R3643 T13608 T13604 pobj datasets,in
R3644 T13609 T13602 punct ", ",identified
R3645 T13610 T13602 advcl suggesting,identified
R3646 T13611 T13612 mark that,are
R3647 T13612 T13610 ccomp are,suggesting
R3648 T13613 T13614 det these,QTL
R3649 T13614 T13612 nsubj QTL,are
R3650 T13615 T13612 acomp reproducible,are
R3651 T13616 T13602 punct .,identified
R3652 T13618 T13619 advmod Second,overlap
R3653 T13620 T13619 punct ", ",overlap
R3654 T13621 T13622 amod many,QTL
R3655 T13622 T13619 nsubj QTL,overlap
R3656 T13623 T13622 acl identified,QTL
R3657 T13624 T13623 prep in,identified
R3658 T13625 T13626 det the,study
R3659 T13626 T13624 pobj study,in
R3660 T13627 T13626 amod present,study
R3661 T13628 T13619 prep with,overlap
R3662 T13629 T13630 compound arthritis,QTL
R3663 T13630 T13628 pobj QTL,with
R3664 T13631 T13632 advmod previously,identified
R3665 T13632 T13630 acl identified,QTL
R3666 T13633 T13630 punct ", ",QTL
R3667 T13634 T13630 prep including,QTL
R3668 T13635 T13636 nmod loci,1
R3669 T13636 T13634 pobj 1,including
R3670 T13637 T13636 punct ", ",1
R3671 T13638 T13636 conj 2,1
R3672 T13639 T13638 punct ", ",2
R3673 T13640 T13638 conj 5,2
R3674 T13641 T13640 cc and,5
R3675 T13642 T13640 conj 6,5
R3676 T13643 T13619 punct .,overlap
R3677 T13645 T13646 prep In,revealed
R3678 T13647 T13645 pobj addition,In
R3679 T13648 T13646 punct ", ",revealed
R3680 T13649 T13650 amod syntenic,analysis
R3681 T13650 T13646 nsubj analysis,revealed
R3682 T13651 T13652 mark that,linked
R3683 T13652 T13646 ccomp linked,revealed
R3684 T13653 T13654 det the,regions
R3685 T13654 T13652 nsubjpass regions,linked
R3686 T13655 T13654 nmod counterpart,regions
R3687 T13656 T13654 amod genomic,regions
R3688 T13657 T13654 prep on,regions
R3689 T13658 T13659 det the,genome
R3690 T13659 T13657 pobj genome,on
R3691 T13660 T13659 amod human,genome
R3692 T13661 T13659 prep of,genome
R3693 T13662 T13661 pobj many,of
R3694 T13663 T13662 prep of,many
R3695 T13664 T13665 det these,QTL
R3696 T13665 T13663 pobj QTL,of
R3697 T13666 T13665 nummod eight,QTL
R3698 T13667 T13652 auxpass are,linked
R3699 T13668 T13652 prep to,linked
R3700 T13669 T13668 pobj RA,to
R3701 T13670 T13646 punct .,revealed
R3702 T13672 T13673 prep For,are
R3703 T13674 T13675 quantmod five,eight
R3704 T13675 T13678 nummod eight,QTL
R3705 T13676 T13675 quantmod of,eight
R3706 T13677 T13675 quantmod the,eight
R3707 T13678 T13672 pobj QTL,For
R3708 T13679 T13680 amod small,effect
R3709 T13680 T13678 compound effect,QTL
R3710 T13681 T13680 punct -,effect
R3711 T13682 T13683 det the,alleles
R3712 T13683 T13673 nsubj alleles,are
R3713 T13684 T13683 nmod DBA,alleles
R3714 T13685 T13684 punct /,DBA
R3715 T13686 T13684 nummod 1,DBA
R3716 T13687 T13688 det the,alleles
R3717 T13688 T13673 attr alleles,are
R3718 T13689 T13690 npadvmod arthritis,enhancing
R3719 T13690 T13688 amod enhancing,alleles
R3720 T13691 T13690 punct -,enhancing
R3721 T13692 T13673 punct ", ",are
R3722 T13693 T13694 mark while,are
R3723 T13694 T13673 advcl are,are
R3724 T13695 T13696 det the,alleles
R3725 T13696 T13694 nsubj alleles,are
R3726 T13697 T13696 compound FVBN,alleles
R3727 T13698 T13699 det the,alleles
R3728 T13699 T13694 attr alleles,are
R3729 T13700 T13701 npadvmod arthritis,enhancing
R3730 T13701 T13699 amod enhancing,alleles
R3731 T13702 T13701 punct -,enhancing
R3732 T13703 T13694 prep in,are
R3733 T13704 T13705 det the,QTL
R3734 T13705 T13703 pobj QTL,in
R3735 T13706 T13705 amod other,QTL
R3736 T13707 T13705 nummod three,QTL
R3737 T13708 T13694 punct ", ",are
R3738 T13709 T13694 advcl indicating,are
R3739 T13710 T13711 mark that,come
R3740 T13711 T13709 ccomp come,indicating
R3741 T13712 T13713 det some,genes
R3742 T13713 T13711 nsubj genes,come
R3743 T13714 T13713 compound susceptibility,genes
R3744 T13715 T13711 aux could,come
R3745 T13716 T13711 prep from,come
R3746 T13717 T13718 det the,strain
R3747 T13718 T13716 pobj strain,from
R3748 T13719 T13718 amod resistant,strain
R3749 T13720 T13673 punct .,are
R3750 T13722 T13723 advmod Interestingly,overlap
R3751 T13724 T13723 punct ", ",overlap
R3752 T13725 T13726 nmod loci,2
R3753 T13726 T13723 nsubj 2,overlap
R3754 T13727 T13726 cc and,2
R3755 T13728 T13726 conj 7,2
R3756 T13729 T13723 advmod partially,overlap
R3757 T13730 T13723 prep with,overlap
R3758 T13731 T13732 nummod two,QTL
R3759 T13732 T13730 pobj QTL,with
R3760 T13733 T13734 npadvmod arthritis,related
R3761 T13734 T13732 amod related,QTL
R3762 T13735 T13734 punct -,related
R3763 T13736 T13732 acl identified,QTL
R3764 T13737 T13736 agent by,identified
R3765 T13738 T13737 pobj us,by
R3766 T13739 T13736 prep in,identified
R3767 T13740 T13741 det the,progeny
R3768 T13741 T13739 pobj progeny,in
R3769 T13742 T13741 amod same,progeny
R3770 T13743 T13741 compound F2,progeny
R3771 T13744 T13745 punct [,10
R3772 T13745 T13723 parataxis 10,overlap
R3773 T13746 T13745 punct ],10
R3774 T13747 T13723 punct .,overlap
R3775 T13749 T13750 nsubjpass Locus,located
R3776 T13751 T13749 nummod 2,Locus
R3777 T13752 T13750 auxpass was,located
R3778 T13753 T13750 prep at,located
R3779 T13754 T13755 det the,region
R3780 T13755 T13753 pobj region,at
R3781 T13756 T13755 amod same,region
R3782 T13757 T13755 amod genomic,region
R3783 T13758 T13755 prep as,region
R3784 T13759 T13758 pobj Cia27,as
R3785 T13760 T13759 punct ", ",Cia27
R3786 T13761 T13762 det a,QTL
R3787 T13762 T13759 appos QTL,Cia27
R3788 T13763 T13762 acl controlling,QTL
R3789 T13764 T13765 compound IgG2a,levels
R3790 T13765 T13763 dobj levels,controlling
R3791 T13766 T13765 compound antibody,levels
R3792 T13767 T13765 prep to,levels
R3793 T13768 T13767 pobj collagen,to
R3794 T13769 T13768 nummod II,collagen
R3795 T13770 T13750 punct .,located
R3796 T13772 T13773 advmod Recently,refined
R3797 T13774 T13773 punct ", ",refined
R3798 T13775 T13773 nsubj we,refined
R3799 T13776 T13773 aux have,refined
R3800 T13777 T13778 det this,QTL
R3801 T13778 T13773 dobj QTL,refined
R3802 T13779 T13773 prep into,refined
R3803 T13780 T13781 det a,region
R3804 T13781 T13779 pobj region,into
R3805 T13782 T13783 nummod 4.1,Mb
R3806 T13783 T13781 nmod Mb,region
R3807 T13784 T13781 amod genomic,region
R3808 T13785 T13773 cc and,refined
R3809 T13786 T13773 conj showed,refined
R3810 T13787 T13788 mark that,regulates
R3811 T13788 T13786 ccomp regulates,showed
R3812 T13789 T13790 det a,gene
R3813 T13790 T13788 nsubj gene,regulates
R3814 T13791 T13790 prep within,gene
R3815 T13792 T13793 det this,region
R3816 T13793 T13791 pobj region,within
R3817 T13794 T13795 compound CIA,severity
R3818 T13795 T13788 dobj severity,regulates
R3819 T13796 T13788 prep by,regulates
R3820 T13797 T13796 pcomp controlling,by
R3821 T13798 T13799 det the,levels
R3822 T13799 T13797 dobj levels,controlling
R3823 T13800 T13799 compound IgG2a,levels
R3824 T13801 T13799 compound antibody,levels
R3825 T13802 T13799 prep to,levels
R3826 T13803 T13802 pobj collagen,to
R3827 T13804 T13803 nummod II,collagen
R3828 T13805 T13806 punct [,31
R3829 T13806 T13786 parataxis 31,showed
R3830 T13807 T13806 punct ],31
R3831 T13808 T13773 punct .,refined
R3832 T13810 T13811 nsubj Locus,overlaps
R3833 T13812 T13810 nummod 7,Locus
R3834 T13813 T13810 prep on,Locus
R3835 T13814 T13813 pobj chromosome,on
R3836 T13815 T13814 nummod 16,chromosome
R3837 T13816 T13811 prep with,overlaps
R3838 T13817 T13816 pobj Lp1,with
R3839 T13818 T13817 punct ", ",Lp1
R3840 T13819 T13820 dep which,controls
R3841 T13820 T13817 relcl controls,Lp1
R3842 T13821 T13822 compound lymphocyte,proliferation
R3843 T13822 T13820 dobj proliferation,controls
R3844 T13823 T13811 punct .,overlaps
R3845 T13825 T13826 advmod Furthermore,controls
R3846 T13827 T13826 punct ", ",controls
R3847 T13828 T13826 prep according,controls
R3848 T13829 T13828 prep to,according
R3849 T13830 T13831 poss our,data
R3850 T13831 T13829 pobj data,to
R3851 T13832 T13831 amod unpublished,data
R3852 T13833 T13826 punct ", ",controls
R3853 T13834 T13826 nsubj loci,controls
R3854 T13835 T13834 nummod 8,loci
R3855 T13836 T13834 prep on,loci
R3856 T13837 T13836 pobj chromosome,on
R3857 T13838 T13837 nummod 17,chromosome
R3858 T13839 T13840 compound lymphocyte,adherence
R3859 T13840 T13826 dobj adherence,controls
R3860 T13841 T13826 prep during,controls
R3861 T13842 T13841 pobj development,during
R3862 T13843 T13842 prep of,development
R3863 T13844 T13843 pobj CIA,of
R3864 T13845 T13826 punct .,controls
R3865 T13847 T13848 advmod Therefore,affect
R3866 T13849 T13848 punct ", ",affect
R3867 T13850 T13851 det the,gene
R3868 T13851 T13848 nsubj gene,affect
R3869 T13852 T13851 prep within,gene
R3870 T13853 T13854 det the,QTL
R3871 T13854 T13852 pobj QTL,within
R3872 T13855 T13856 amod small,effect
R3873 T13856 T13854 compound effect,QTL
R3874 T13857 T13856 punct -,effect
R3875 T13858 T13848 aux could,affect
R3876 T13859 T13860 compound CIA,severity
R3877 T13860 T13848 dobj severity,affect
R3878 T13861 T13848 prep through,affect
R3879 T13862 T13861 pcomp controlling,through
R3880 T13863 T13864 npadvmod arthritis,related
R3881 T13864 T13866 amod related,phenotypes
R3882 T13865 T13864 punct -,related
R3883 T13866 T13862 dobj phenotypes,controlling
R3884 T13867 T13848 punct .,affect
R3885 T13869 T13870 amod Several,studies
R3886 T13870 T13871 nsubjpass studies,carried
R3887 T13872 T13871 aux have,carried
R3888 T13873 T13871 auxpass been,carried
R3889 T13874 T13871 prt out,carried
R3890 T13875 T13876 aux to,detect
R3891 T13876 T13871 advcl detect,carried
R3892 T13877 T13878 compound gene,expression
R3893 T13878 T13876 dobj expression,detect
R3894 T13879 T13876 prep during,detect
R3895 T13880 T13879 pobj CIA,during
R3896 T13881 T13871 punct ", ",carried
R3897 T13882 T13883 dep all,used
R3898 T13883 T13871 ccomp used,carried
R3899 T13884 T13882 prep of,all
R3900 T13885 T13884 pobj which,of
R3901 T13886 T13883 dobj joints,used
R3902 T13887 T13883 prep as,used
R3903 T13888 T13889 det the,tissue
R3904 T13889 T13887 pobj tissue,as
R3905 T13890 T13889 compound target,tissue
R3906 T13891 T13892 punct [,22
R3907 T13892 T13871 parataxis 22,carried
R3908 T13893 T13892 nummod 15,22
R3909 T13894 T13892 punct ",",22
R3910 T13895 T13892 nummod 16,22
R3911 T13896 T13892 punct ",",22
R3912 T13897 T13892 nummod 21,22
R3913 T13898 T13892 punct ",",22
R3914 T13899 T13892 punct ],22
R3915 T13900 T13871 punct .,carried
R3916 T13902 T13903 det This,study
R3917 T13903 T13904 nsubj study,detected
R3918 T13905 T13904 punct ", ",detected
R3919 T13906 T13904 prep for,detected
R3920 T13907 T13908 det the,time
R3921 T13908 T13906 pobj time,for
R3922 T13909 T13908 amod first,time
R3923 T13910 T13904 punct ", ",detected
R3924 T13911 T13912 compound gene,expression
R3925 T13912 T13904 dobj expression,detected
R3926 T13913 T13904 prep in,detected
R3927 T13914 T13913 pobj LNs,in
R3928 T13915 T13904 prep during,detected
R3929 T13916 T13915 pobj CIA,during
R3930 T13917 T13904 punct .,detected
R3931 T13919 T13920 nsubj We,present
R3932 T13921 T13922 det an,study
R3933 T13922 T13920 dobj study,present
R3934 T13923 T13922 amod extensive,study
R3935 T13924 T13922 prep of,study
R3936 T13925 T13926 compound gene,patterns
R3937 T13926 T13924 pobj patterns,of
R3938 T13927 T13926 compound expression,patterns
R3939 T13928 T13922 prep in,study
R3940 T13929 T13928 pobj LNs,in
R3941 T13930 T13929 prep of,LNs
R3942 T13931 T13932 preconj both,strains
R3943 T13932 T13930 pobj strains,of
R3944 T13933 T13934 advmod genetically,susceptible
R3945 T13934 T13932 amod susceptible,strains
R3946 T13935 T13934 cc and,susceptible
R3947 T13936 T13934 conj resistant,susceptible
R3948 T13937 T13922 prep at,study
R3949 T13938 T13939 nummod four,phases
R3950 T13939 T13937 pobj phases,at
R3951 T13940 T13939 amod different,phases
R3952 T13941 T13939 prep of,phases
R3953 T13942 T13941 pobj CIA,of
R3954 T13943 T13920 punct .,present
R3955 T13945 T13946 prep In,were
R3956 T13947 T13948 det both,strains
R3957 T13948 T13945 pobj strains,In
R3958 T13949 T13946 punct ", ",were
R3959 T13950 T13951 advmod differentially,regulated
R3960 T13951 T13952 amod regulated,genes
R3961 T13952 T13946 nsubj genes,were
R3962 T13953 T13954 advmod highly,concentrated
R3963 T13954 T13946 acomp concentrated,were
R3964 T13955 T13946 prep at,were
R3965 T13956 T13957 det the,phases
R3966 T13957 T13955 pobj phases,at
R3967 T13958 T13957 nmod PI,phases
R3968 T13959 T13958 cc and,PI
R3969 T13960 T13958 conj CA,PI
R3970 T13961 T13946 punct ", ",were
R3971 T13962 T13946 cc and,were
R3972 T13963 T13964 advmod only,number
R3973 T13964 T13967 nsubjpass number,expressed
R3974 T13965 T13964 det a,number
R3975 T13966 T13964 amod small,number
R3976 T13967 T13946 conj expressed,were
R3977 T13968 T13964 prep of,number
R3978 T13969 T13968 pobj genes,of
R3979 T13970 T13967 auxpass were,expressed
R3980 T13971 T13967 advmod differentially,expressed
R3981 T13972 T13967 prep in,expressed
R3982 T13973 T13974 nummod two,phases
R3983 T13974 T13972 pobj phases,in
R3984 T13975 T13973 cc or,two
R3985 T13976 T13973 conj three,two
R3986 T13977 T13967 punct .,expressed
R3987 T13979 T13980 nsubj This,indicates
R3988 T13981 T13982 mark that,were
R3989 T13982 T13980 ccomp were,indicates
R3990 T13983 T13984 amod biological,responses
R3991 T13984 T13982 nsubj responses,were
R3992 T13985 T13984 prep in,responses
R3993 T13986 T13985 pobj LNs,in
R3994 T13987 T13982 acomp stronger,were
R3995 T13988 T13987 prep in,stronger
R3996 T13989 T13990 det the,phases
R3997 T13990 T13988 pobj phases,in
R3998 T13991 T13990 nmod PI,phases
R3999 T13992 T13991 cc and,PI
R4000 T13993 T13991 conj CA,PI
R4001 T13994 T13987 prep than,stronger
R4002 T13995 T13994 prep in,than
R4003 T13996 T13997 det the,phase
R4004 T13997 T13995 pobj phase,in
R4005 T13998 T13997 compound OA,phase
R4006 T13999 T13982 punct ", ",were
R4007 T14000 T13982 cc and,were
R4008 T14001 T14002 det the,responses
R4009 T14002 T14003 nsubj responses,were
R4010 T14003 T13982 conj were,were
R4011 T14004 T14002 prep at,responses
R4012 T14005 T14006 amod different,phases
R4013 T14006 T14004 pobj phases,at
R4014 T14007 T14003 acomp different,were
R4015 T14008 T13980 punct .,indicates
R4016 T14010 T14011 advmod When,comparing
R4017 T14011 T14012 advcl comparing,found
R4018 T14013 T14014 det the,susceptible
R4019 T14014 T14011 dative susceptible,comparing
R4020 T14015 T14011 prep to,comparing
R4021 T14016 T14017 det the,resistant
R4022 T14017 T14015 pobj resistant,to
R4023 T14018 T14011 dobj strain,comparing
R4024 T14019 T14012 punct ", ",found
R4025 T14020 T14021 det the,difference
R4026 T14021 T14012 nsubjpass difference,found
R4027 T14022 T14021 amod biggest,difference
R4028 T14023 T14012 auxpass was,found
R4029 T14024 T14012 prep in,found
R4030 T14025 T14026 nummod one,cluster
R4031 T14026 T14024 pobj cluster,in
R4032 T14027 T14026 prep of,cluster
R4033 T14028 T14027 pobj genes,of
R4034 T14029 T14026 punct (,cluster
R4035 T14030 T14026 appos cluster,cluster
R4036 T14031 T14030 nummod IV,cluster
R4037 T14032 T14033 punct ", ",Figure
R4038 T14033 T14012 parataxis Figure,found
R4039 T14034 T14033 nummod 2,Figure
R4040 T14035 T14033 punct ),Figure
R4041 T14036 T14012 punct .,found
R4042 T14038 T14039 det These,genes
R4043 T14039 T14040 nsubj genes,had
R4044 T14041 T14042 det a,expression
R4045 T14042 T14040 dobj expression,had
R4046 T14043 T14042 amod higher,expression
R4047 T14044 T14042 prep in,expression
R4048 T14045 T14044 pobj DBA,in
R4049 T14046 T14045 punct /,DBA
R4050 T14047 T14045 nummod 1,DBA
R4051 T14048 T14042 prep than,expression
R4052 T14049 T14048 prep in,than
R4053 T14050 T14051 compound FVB,N
R4054 T14051 T14049 pobj N,in
R4055 T14052 T14051 punct /,N
R4056 T14053 T14040 prep at,had
R4057 T14054 T14055 det the,phases
R4058 T14055 T14053 pobj phases,at
R4059 T14056 T14055 amod early,phases
R4060 T14057 T14055 prep of,phases
R4061 T14058 T14057 pobj CIA,of
R4062 T14059 T14060 punct (,NC
R4063 T14060 T14055 parataxis NC,phases
R4064 T14061 T14060 punct ", ",NC
R4065 T14062 T14060 conj PI,NC
R4066 T14063 T14062 cc and,PI
R4067 T14064 T14062 conj OA,PI
R4068 T14065 T14060 punct ),NC
R4069 T14066 T14040 cc and,had
R4070 T14067 T14068 det the,pattern
R4071 T14068 T14040 conj pattern,had
R4072 T14069 T14068 amod opposite,pattern
R4073 T14070 T14068 compound expression,pattern
R4074 T14071 T14068 prep in,pattern
R4075 T14072 T14073 det the,phase
R4076 T14073 T14071 pobj phase,in
R4077 T14074 T14073 compound CA,phase
R4078 T14075 T14040 punct .,had
R4079 T14077 T14078 compound GO,classification
R4080 T14078 T14080 nsubj classification,revealed
R4081 T14079 T14078 compound term,classification
R4082 T14081 T14082 mark that,related
R4083 T14082 T14080 ccomp related,revealed
R4084 T14083 T14084 det these,genes
R4085 T14084 T14082 nsubjpass genes,related
R4086 T14085 T14082 auxpass were,related
R4087 T14086 T14082 prep to,related
R4088 T14087 T14088 compound lymphocyte,proliferation
R4089 T14088 T14086 pobj proliferation,to
R4090 T14089 T14088 cc and,proliferation
R4091 T14090 T14088 conj activation,proliferation
R4092 T14091 T14082 punct ", ",related
R4093 T14092 T14082 advcl suggesting,related
R4094 T14093 T14094 mark that,are
R4095 T14094 T14092 ccomp are,suggesting
R4096 T14095 T14094 nsubj lymphocytes,are
R4097 T14096 T14095 prep in,lymphocytes
R4098 T14097 T14098 det the,strain
R4099 T14098 T14096 pobj strain,in
R4100 T14099 T14098 nmod DBA,strain
R4101 T14100 T14099 punct /,DBA
R4102 T14123 T14115 advcl existed,is
R4103 T14101 T14099 nummod 1,DBA
R4104 T14124 T14125 det the,difference
R4105 T14102 T14103 advmod more,activated
R4106 T14125 T14123 nsubj difference,existed
R4107 T14126 T14125 compound expression,difference
R4108 T14127 T14125 prep between,difference
R4109 T14103 T14094 acomp activated,are
R4110 T14128 T14129 det the,strains
R4111 T14129 T14127 pobj strains,between
R4112 T14104 T14103 prep than,activated
R4113 T14130 T14129 nummod two,strains
R4114 T14131 T14123 prep in,existed
R4115 T14132 T14131 pobj mice,in
R4116 T14105 T14104 pobj those,than
R4117 T14133 T14132 prep without,mice
R4118 T14134 T14133 pobj immunisation,without
R4119 T14135 T14115 punct .,is
R4120 T14106 T14105 prep in,those
R4121 T14137 T14138 advmod Additionally,upregulated
R4122 T14107 T14108 det the,strain
R4123 T14139 T14138 punct ", ",upregulated
R4124 T14108 T14106 pobj strain,in
R4125 T14140 T14141 det some,genes
R4126 T14141 T14138 nsubjpass genes,upregulated
R4127 T14142 T14141 acl related,genes
R4128 T14109 T14110 compound FVB,N
R4129 T14143 T14142 prep to,related
R4130 T14144 T14145 det the,response
R4131 T14110 T14108 compound N,strain
R4132 T14145 T14143 pobj response,to
R4133 T14146 T14145 amod immune,response
R4134 T14147 T14138 auxpass were,upregulated
R4135 T14148 T14138 prep in,upregulated
R4136 T14149 T14150 det the,strain
R4137 T14150 T14148 pobj strain,in
R4138 T14111 T14110 punct /,N
R4139 T14151 T14150 nmod DBA,strain
R4140 T14152 T14151 punct /,DBA
R4141 T14153 T14151 nummod 1,DBA
R4142 T14112 T14080 punct .,revealed
R4143 T14154 T14148 cc but,in
R4144 T14155 T14154 neg not,but
R4145 T14156 T14148 conj in,in
R4146 T14157 T14158 det the,strain
R4147 T14114 T14115 advmod However,is
R4148 T14158 T14156 pobj strain,in
R4149 T14159 T14160 compound FVB,N
R4150 T14160 T14158 compound N,strain
R4151 T14161 T14160 punct /,N
R4152 T14116 T14115 punct ", ",is
R4153 T14162 T14138 prep during,upregulated
R4154 T14163 T14162 pobj CIA,during
R4155 T14164 T14138 punct .,upregulated
R4156 T14166 T14167 det These,differences
R4157 T14117 T14118 det this,difference
R4158 T14167 T14168 nsubj differences,explain
R4159 T14169 T14168 aux could,explain
R4160 T14118 T14115 nsubj difference,is
R4161 T14170 T14171 advmod why,occurred
R4162 T14119 T14115 neg not,is
R4163 T14120 T14121 npadvmod CIA,specific
R4164 T14171 T14168 ccomp occurred,explain
R4165 T14172 T14173 det a,response
R4166 T14121 T14115 acomp specific,is
R4167 T14173 T14171 nsubj response,occurred
R4168 T14174 T14173 amod higher,response
R4169 T14175 T14173 compound antibody,response
R4170 T14122 T14123 mark because,existed
R4171 T14176 T14173 prep to,response
R4172 T14177 T14176 pobj collagen,to
R4173 T14178 T14177 nummod II,collagen
R4174 T14179 T14171 prep in,occurred
R4175 T14229 T14228 prep to,according
R4176 T14180 T14181 det the,strain
R4177 T14181 T14179 pobj strain,in
R4178 T14182 T14181 nmod DBA,strain
R4179 T14183 T14182 punct /,DBA
R4180 T14230 T14231 poss their,patterns
R4181 T14184 T14182 nummod 1,DBA
R4182 T14185 T14171 prep compared,occurred
R4183 T14231 T14229 pobj patterns,to
R4184 T14186 T14185 prep to,compared
R4185 T14187 T14188 det the,strain
R4186 T14188 T14186 pobj strain,to
R4187 T14189 T14190 compound FVB,N
R4188 T14190 T14188 compound N,strain
R4189 T14232 T14233 compound gene,expression
R4190 T14191 T14190 punct /,N
R4191 T14192 T14168 punct ", ",explain
R4192 T14193 T14168 cc and,explain
R4193 T14194 T14195 aux might,explain
R4194 T14233 T14231 compound expression,patterns
R4195 T14195 T14168 conj explain,explain
R4196 T14234 T14213 prep during,identified
R4197 T14196 T14195 advmod partially,explain
R4198 T14197 T14198 det the,difference
R4199 T14198 T14195 dobj difference,explain
R4200 T14199 T14198 prep of,difference
R4201 T14235 T14234 pobj CIA,during
R4202 T14200 T14201 det the,susceptibility
R4203 T14201 T14199 pobj susceptibility,of
R4204 T14202 T14201 prep to,susceptibility
R4205 T14203 T14202 pobj CIA,to
R4206 T14236 T14235 cc and,CIA
R4207 T14204 T14198 prep between,difference
R4208 T14205 T14206 det both,strains
R4209 T14206 T14204 pobj strains,between
R4210 T14237 T14238 poss their,locations
R4211 T14207 T14168 punct .,explain
R4212 T14209 T14210 compound Twenty,one
R4213 T14238 T14235 conj locations,CIA
R4214 T14210 T14212 nummod one,genes
R4215 T14211 T14210 punct -,one
R4216 T14212 T14213 nsubjpass genes,identified
R4217 T14239 T14238 amod genomic,locations
R4218 T14214 T14213 auxpass were,identified
R4219 T14215 T14213 prep as,identified
R4220 T14216 T14217 amod potential,genes
R4221 T14240 T14213 punct .,identified
R4222 T14217 T14215 pobj genes,as
R4223 T14218 T14217 compound candidate,genes
R4224 T14219 T14213 prep for,identified
R4225 T14242 T14243 det No,genes
R4226 T14220 T14221 quantmod six,eight
R4227 T14221 T14224 nummod eight,QTL
R4228 T14222 T14221 quantmod of,eight
R4229 T14223 T14221 quantmod the,eight
R4230 T14243 T14245 nsubjpass genes,located
R4231 T14224 T14219 pobj QTL,for
R4232 T14225 T14226 amod small,effect
R4233 T14226 T14224 compound effect,QTL
R4234 T14244 T14243 compound candidate,genes
R4235 T14227 T14226 punct -,effect
R4236 T14228 T14213 prep according,identified
R4237 T14246 T14245 auxpass were,located
R4238 T14247 T14245 prep in,located
R4239 T14248 T14249 nmod QTL,4
R4240 T14336 T14337 advmod Moreover,attenuate
R4241 T14249 T14247 pobj 4,in
R4242 T14338 T14337 punct ", ",attenuate
R4243 T14339 T14337 nsubj inhibitors,attenuate
R4244 T14340 T14339 prep of,inhibitors
R4245 T14341 T14342 compound p38,MAPK
R4246 T14250 T14249 cc and,4
R4247 T14342 T14340 pobj MAPK,of
R4248 T14343 T14337 aux could,attenuate
R4249 T14344 T14337 dobj CIA,attenuate
R4250 T14251 T14249 conj 7,4
R4251 T14345 T14337 prep in,attenuate
R4252 T14252 T14245 punct ", ",located
R4253 T14346 T14345 pobj rats,in
R4254 T14347 T14348 punct [,33
R4255 T14348 T14337 parataxis 33,attenuate
R4256 T14349 T14348 punct ],33
R4257 T14253 T14245 advcl suggesting,located
R4258 T14254 T14255 mark that,affect
R4259 T14350 T14337 punct ", ",attenuate
R4260 T14351 T14337 cc and,attenuate
R4261 T14352 T14353 compound p38,MAPK
R4262 T14255 T14253 ccomp affect,suggesting
R4263 T14353 T14354 nsubj MAPK,becoming
R4264 T14354 T14337 conj becoming,attenuate
R4265 T14355 T14354 aux is,becoming
R4266 T14356 T14357 det a,target
R4267 T14256 T14257 compound QTG,polymorphisms
R4268 T14357 T14354 attr target,becoming
R4269 T14358 T14357 amod potential,target
R4270 T14359 T14357 amod therapeutic,target
R4271 T14257 T14255 nsubj polymorphisms,affect
R4272 T14360 T14354 prep in,becoming
R4273 T14361 T14360 pobj RA,in
R4274 T14362 T14363 punct [,32
R4275 T14363 T14354 parataxis 32,becoming
R4276 T14258 T14257 prep of,polymorphisms
R4277 T14364 T14363 punct ],32
R4278 T14365 T14337 punct .,attenuate
R4279 T14367 T14368 nsubj Stat5a,is
R4280 T14259 T14260 det the,genes
R4281 T14369 T14367 punct ", ",Stat5a
R4282 T14370 T14371 det a,gene
R4283 T14260 T14258 pobj genes,of
R4284 T14371 T14367 appos gene,Stat5a
R4285 T14372 T14371 compound candidate,gene
R4286 T14373 T14371 prep for,gene
R4287 T14374 T14373 pobj loci,for
R4288 T14261 T14260 compound susceptibility,genes
R4289 T14375 T14374 nummod 6,loci
R4290 T14376 T14368 punct ", ",is
R4291 T14377 T14378 det an,molecule
R4292 T14378 T14368 attr molecule,is
R4293 T14379 T14378 amod essential,molecule
R4294 T14380 T14378 prep for,molecule
R4295 T14381 T14382 compound lymphoid,development
R4296 T14262 T14257 prep inside,polymorphisms
R4297 T14382 T14380 pobj development,for
R4298 T14383 T14382 cc and,development
R4299 T14384 T14382 conj differentiation,development
R4300 T14385 T14386 punct [,34
R4301 T14263 T14264 det these,QTL
R4302 T14386 T14368 parataxis 34,is
R4303 T14387 T14386 punct ],34
R4304 T14388 T14368 punct .,is
R4305 T14264 T14262 pobj QTL,inside
R4306 T14390 T14391 npadvmod Stat5a,deficient
R4307 T14391 T14393 amod deficient,mice
R4308 T14265 T14264 nummod two,QTL
R4309 T14392 T14391 punct -,deficient
R4310 T14393 T14394 nsubjpass mice,reported
R4311 T14266 T14255 aux might,affect
R4312 T14395 T14394 auxpass were,reported
R4313 T14396 T14397 aux to,lose
R4314 T14397 T14394 xcomp lose,reported
R4315 T14267 T14255 neg not,affect
R4316 T14398 T14397 dobj tolerance,lose
R4317 T14399 T14397 punct ", ",lose
R4318 T14400 T14397 advcl resulting,lose
R4319 T14401 T14400 prep in,resulting
R4320 T14268 T14269 det the,phenotype
R4321 T14402 T14403 det the,development
R4322 T14403 T14401 pobj development,in
R4323 T14404 T14403 prep of,development
R4324 T14269 T14255 dobj phenotype,affect
R4325 T14405 T14406 amod autoimmune,diseases
R4326 T14406 T14404 pobj diseases,of
R4327 T14270 T14255 prep by,affect
R4328 T14407 T14394 punct .,reported
R4329 T14409 T14410 nsubjpass Stat5a,suggested
R4330 T14271 T14270 pcomp regulating,by
R4331 T14411 T14410 auxpass is,suggested
R4332 T14412 T14413 aux to,contribute
R4333 T14272 T14273 compound gene,expression
R4334 T14413 T14410 xcomp contribute,suggested
R4335 T14414 T14413 prep to,contribute
R4336 T14415 T14414 pobj tolerance,to
R4337 T14273 T14271 dobj expression,regulating
R4338 T14416 T14413 prep through,contribute
R4339 T14417 T14416 pobj maintenance,through
R4340 T14418 T14417 prep of,maintenance
R4341 T14419 T14420 det the,population
R4342 T14420 T14418 pobj population,of
R4343 T14421 T14420 nmod CD4+CD25+,population
R4344 T14422 T14420 amod regulatory,population
R4345 T14274 T14245 punct .,located
R4346 T14423 T14424 compound T,cell
R4347 T14424 T14420 compound cell,population
R4348 T14425 T14426 punct [,35
R4349 T14426 T14410 parataxis 35,suggested
R4350 T14276 T14277 quantmod Two,21
R4351 T14427 T14426 punct ],35
R4352 T14428 T14410 punct .,suggested
R4353 T14430 T14431 advmod Therefore,presented
R4354 T14277 T14280 nummod 21,genes
R4355 T14432 T14431 punct ", ",presented
R4356 T14278 T14277 quantmod of,21
R4357 T14433 T14431 nsubj we,presented
R4358 T14434 T14431 aux have,presented
R4359 T14435 T14436 det a,strategy
R4360 T14436 T14431 dobj strategy,presented
R4361 T14279 T14277 quantmod the,21
R4362 T14437 T14438 aux to,identify
R4363 T14438 T14436 advcl identify,strategy
R4364 T14280 T14282 nsubjpass genes,reported
R4365 T14439 T14440 amod small,effect
R4366 T14281 T14280 compound candidate,genes
R4367 T14440 T14442 compound effect,QTL
R4368 T14283 T14282 auxpass were,reported
R4369 T14284 T14285 aux to,involved
R4370 T14441 T14440 punct -,effect
R4371 T14285 T14282 xcomp involved,reported
R4372 T14442 T14438 dobj QTL,identify
R4373 T14443 T14438 cc and,identify
R4374 T14444 T14438 conj search,identify
R4375 T14286 T14285 auxpass be,involved
R4376 T14445 T14444 prep for,search
R4377 T14446 T14447 amod potential,genes
R4378 T14287 T14285 prep in,involved
R4379 T14447 T14445 pobj genes,for
R4380 T14448 T14447 compound candidate,genes
R4381 T14449 T14444 prep within,search
R4382 T14450 T14449 pobj them,within
R4383 T14288 T14287 pobj arthritis,in
R4384 T14451 T14431 punct .,presented
R4385 T14289 T14282 punct .,reported
R4386 T14453 T14454 advmod However,is
R4387 T14455 T14454 punct ", ",is
R4388 T14291 T14292 nsubj Mapk14,regulates
R4389 T14456 T14454 nsubj it,is
R4390 T14457 T14454 acomp noteworthy,is
R4391 T14458 T14459 mark that,lead
R4392 T14459 T14454 ccomp lead,is
R4393 T14460 T14461 det the,threshold
R4394 T14461 T14459 nsubj threshold,lead
R4395 T14462 T14461 amod low,threshold
R4396 T14293 T14291 punct ", ",Mapk14
R4397 T14463 T14461 amod statistical,threshold
R4398 T14464 T14461 cc and,threshold
R4399 T14465 T14466 amod small,number
R4400 T14466 T14461 conj number,threshold
R4401 T14294 T14295 det a,gene
R4402 T14467 T14466 prep of,number
R4403 T14468 T14467 pobj animals,of
R4404 T14469 T14466 prep per,number
R4405 T14295 T14291 nmod gene,Mapk14
R4406 T14470 T14469 pobj group,per
R4407 T14471 T14459 aux could,lead
R4408 T14472 T14459 prep to,lead
R4409 T14296 T14295 nmod candidate,gene
R4410 T14473 T14474 det some,results
R4411 T14474 T14472 pobj results,to
R4412 T14475 T14476 amod false,positive
R4413 T14297 T14295 prep for,gene
R4414 T14476 T14474 amod positive,results
R4415 T14477 T14454 punct .,is
R4416 T14298 T14297 pobj locus,for
R4417 T14479 T14480 prep On,be
R4418 T14481 T14482 det the,level
R4419 T14299 T14298 nummod 8,locus
R4420 T14482 T14479 pobj level,On
R4421 T14483 T14482 compound genome,level
R4422 T14484 T14480 punct ", ",be
R4423 T14300 T14295 cc and,gene
R4424 T14485 T14480 nsubj some,be
R4425 T14486 T14485 prep of,some
R4426 T14487 T14488 det the,QTL
R4427 T14488 T14486 pobj QTL,of
R4428 T14301 T14302 advmod also,called
R4429 T14489 T14488 nummod eight,QTL
R4430 T14490 T14491 amod small,effect
R4431 T14491 T14488 compound effect,QTL
R4432 T14302 T14295 conj called,gene
R4433 T14492 T14491 punct -,effect
R4434 T14493 T14488 acl identified,QTL
R4435 T14494 T14493 advcl using,identified
R4436 T14495 T14496 det a,value
R4437 T14303 T14304 nmod p38,kinase
R4438 T14496 T14494 dobj value,using
R4439 T14497 T14498 advmod very,low
R4440 T14498 T14496 amod low,value
R4441 T14304 T14309 nmod kinase,alpha
R4442 T14499 T14496 compound threshold,value
R4443 T14500 T14501 punct (,0.05
R4444 T14501 T14496 parataxis 0.05,value
R4445 T14502 T14501 nsubj P,0.05
R4446 T14503 T14501 punct <,0.05
R4447 T14504 T14501 punct ),0.05
R4448 T14305 T14306 npadvmod mitogen,activated
R4449 T14505 T14480 aux could,be
R4450 T14506 T14507 amod false,positives
R4451 T14507 T14480 attr positives,be
R4452 T14306 T14304 amod activated,kinase
R4453 T14508 T14480 punct .,be
R4454 T14510 T14511 prep For,identified
R4455 T14307 T14306 punct -,activated
R4456 T14512 T14510 pobj example,For
R4457 T14513 T14511 punct ", ",identified
R4458 T14308 T14304 nmod protein,kinase
R4459 T14514 T14511 nsubjpass locus,identified
R4460 T14515 T14514 nummod 4,locus
R4461 T14309 T14302 oprd alpha,called
R4462 T14310 T14304 punct (,kinase
R4463 T14516 T14511 auxpass was,identified
R4464 T14311 T14304 appos MAPK,kinase
R4465 T14517 T14511 prep with,identified
R4466 T14518 T14519 det a,value
R4467 T14519 T14517 pobj value,with
R4468 T14312 T14309 punct ),alpha
R4469 T14520 T14519 amod low,value
R4470 T14521 T14519 compound P,value
R4471 T14522 T14511 cc and,identified
R4472 T14313 T14292 punct ", ",regulates
R4473 T14523 T14524 aux does,overlap
R4474 T14524 T14511 conj overlap,identified
R4475 T14525 T14524 neg not,overlap
R4476 T14314 T14315 det the,production
R4477 T14315 T14292 dobj production,regulates
R4478 T14526 T14524 prep with,overlap
R4479 T14527 T14528 det any,QTL
R4480 T14316 T14315 prep of,production
R4481 T14528 T14526 pobj QTL,with
R4482 T14529 T14530 advmod previously,identified
R4483 T14530 T14528 amod identified,QTL
R4484 T14317 T14318 npadvmod arthritis,essential
R4485 T14531 T14528 compound arthritis,QTL
R4486 T14532 T14511 punct .,identified
R4487 T14318 T14320 amod essential,cytokines
R4488 T14534 T14535 prep On,result
R4489 T14536 T14537 det the,level
R4490 T14319 T14318 punct -,essential
R4491 T14537 T14534 pobj level,On
R4492 T14538 T14537 compound transcriptome,level
R4493 T14539 T14535 punct ", ",result
R4494 T14320 T14316 pobj cytokines,of
R4495 T14540 T14541 det the,number
R4496 T14541 T14535 nsubj number,result
R4497 T14542 T14541 amod small,number
R4498 T14543 T14541 prep of,number
R4499 T14544 T14543 pobj animals,of
R4500 T14545 T14541 prep per,number
R4501 T14546 T14545 pobj group,per
R4502 T14321 T14320 punct ", ",cytokines
R4503 T14322 T14323 amod such,as
R4504 T14323 T14320 prep as,cytokines
R4505 T14547 T14541 cc and,number
R4506 T14548 T14549 det the,threshold
R4507 T14549 T14541 conj threshold,number
R4508 T14324 T14325 compound tumour,factor
R4509 T14550 T14549 amod low,threshold
R4510 T14551 T14549 acl used,threshold
R4511 T14552 T14553 aux to,detect
R4512 T14325 T14323 pobj factor,as
R4513 T14553 T14551 advcl detect,used
R4514 T14554 T14555 compound gene,expression
R4515 T14555 T14553 dobj expression,detect
R4516 T14326 T14325 compound necrosis,factor
R4517 T14556 T14535 aux could,result
R4518 T14557 T14535 advmod also,result
R4519 T14327 T14325 cc and,factor
R4520 T14558 T14535 prep in,result
R4521 T14559 T14560 amod false,positives
R4522 T14560 T14558 pobj positives,in
R4523 T14561 T14535 prep in,result
R4524 T14328 T14325 conj interleukin,factor
R4525 T14562 T14563 det the,genes
R4526 T14563 T14561 pobj genes,in
R4527 T14329 T14328 punct -,interleukin
R4528 T14564 T14565 advmod differentially,expressed
R4529 T14565 T14563 amod expressed,genes
R4530 T14566 T14535 punct .,result
R4531 T14330 T14328 nummod 1,interleukin
R4532 T14568 T14569 advmod Furthermore,result
R4533 T14331 T14332 punct [,32
R4534 T14570 T14569 punct ", ",result
R4535 T14571 T14572 det the,expression
R4536 T14572 T14569 nsubj expression,result
R4537 T14332 T14292 parataxis 32,regulates
R4538 T14573 T14572 amod differential,expression
R4539 T14574 T14572 prep of,expression
R4540 T14575 T14576 det a,gene
R4541 T14576 T14574 pobj gene,of
R4542 T14333 T14332 punct ],32
R4543 T14577 T14569 aux could,result
R4544 T14578 T14579 preconj not,from
R4545 T14579 T14569 prep from,result
R4546 T14334 T14292 punct .,regulates
R4547 T14580 T14578 advmod only,not
R4548 T14581 T14582 compound allele,difference
R4549 T14582 T14579 pobj difference,from
R4550 T14583 T14582 prep between,difference
R4551 T14584 T14585 nummod two,strains
R4552 T14585 T14583 pobj strains,between
R4553 T14586 T14579 punct ", ",from
R4554 T14587 T14579 cc but,from
R4555 T14588 T14587 advmod also,but
R4556 T14589 T14579 conj from,from
R4557 T14590 T14591 amod other,factors
R4558 T14591 T14589 pobj factors,from
R4559 T14592 T14569 punct .,result
R4560 T14594 T14595 advmod Therefore,confirmed
R4561 T14596 T14595 punct ", ",confirmed
R4562 T14597 T14598 poss our,findings
R4563 T14598 T14595 nsubjpass findings,confirmed
R4564 T14599 T14595 aux should,confirmed
R4565 T14600 T14595 auxpass be,confirmed
R4566 T14601 T14595 prep in,confirmed
R4567 T14602 T14603 amod future,studies
R4568 T14603 T14601 pobj studies,in
R4569 T14604 T14595 punct .,confirmed