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PMC:1860061 / 10345-13198 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T7078 0-5 JJ denotes Small
T7080 5-6 HYPH denotes -
T7079 6-12 NN denotes effect
T7081 13-16 NNS denotes QTL
T7082 17-19 IN denotes of
T7083 20-23 NN denotes CIA
T7084 24-26 IN denotes in
T7085 27-28 -LRB- denotes (
T7086 28-31 NN denotes DBA
T7088 31-32 HYPH denotes /
T7089 32-33 CD denotes 1
T7090 34-35 SYM denotes ×
T7091 36-39 NN denotes FVB
T7093 39-40 HYPH denotes /
T7092 40-41 NN denotes N
T7094 41-42 -RRB- denotes )
T7095 43-45 NN denotes F2
T7087 46-53 NN denotes progeny
T7096 53-183 sentence denotes In a previous study, we carried out a genome screen to identify QTL controlling CIA susceptibility in (DBA/1 × FVB/N) F2 progeny.
T7097 54-56 IN denotes In
T7099 57-58 DT denotes a
T7101 59-67 JJ denotes previous
T7100 68-73 NN denotes study
T7102 73-75 , denotes ,
T7103 75-77 PRP denotes we
T7098 78-85 VBD denotes carried
T7104 86-89 RP denotes out
T7105 90-91 DT denotes a
T7107 92-98 NN denotes genome
T7106 99-105 NN denotes screen
T7108 106-108 TO denotes to
T7109 109-117 VB denotes identify
T7110 118-121 NN denotes QTL
T7111 122-133 VBG denotes controlling
T7112 134-137 NN denotes CIA
T7113 138-152 NN denotes susceptibility
T7114 153-155 IN denotes in
T7115 156-157 -LRB- denotes (
T7116 157-160 NN denotes DBA
T7118 160-161 HYPH denotes /
T7119 161-162 CD denotes 1
T7120 163-164 SYM denotes ×
T7122 165-168 NN denotes FVB
T7123 168-169 HYPH denotes /
T7121 169-170 NN denotes N
T7124 170-171 -RRB- denotes )
T7125 172-174 NN denotes F2
T7117 175-182 NN denotes progeny
T7126 182-183 . denotes .
T7127 183-332 sentence denotes For the phenotype of arthritis severity, only one QTL, Cia2, was identified, with a highly significant logarithm of the odds (LOD) score of 12 [10].
T7128 184-187 IN denotes For
T7130 188-191 DT denotes the
T7131 192-201 NN denotes phenotype
T7132 202-204 IN denotes of
T7133 205-214 NN denotes arthritis
T7134 215-223 NN denotes severity
T7135 223-225 , denotes ,
T7136 225-229 RB denotes only
T7138 230-233 CD denotes one
T7137 234-237 NN denotes QTL
T7139 237-239 , denotes ,
T7140 239-243 NN denotes Cia2
T7141 243-245 , denotes ,
T7142 245-248 VBD denotes was
T7129 249-259 VBN denotes identified
T7143 259-261 , denotes ,
T7144 261-265 IN denotes with
T7145 266-267 DT denotes a
T7147 268-274 RB denotes highly
T7148 275-286 JJ denotes significant
T7149 287-296 NN denotes logarithm
T7150 297-299 IN denotes of
T7151 300-303 DT denotes the
T7152 304-308 NNS denotes odds
T7153 309-310 -LRB- denotes (
T7154 310-313 NN denotes LOD
T7155 313-314 -RRB- denotes )
T7146 315-320 NN denotes score
T7156 321-323 IN denotes of
T7157 324-326 CD denotes 12
T7158 327-328 -LRB- denotes [
T7159 328-330 CD denotes 10
T7160 330-331 -RRB- denotes ]
T7161 331-332 . denotes .
T7162 332-553 sentence denotes However, Cia2 contributed to only 16% of the phenotype variations, indicating that there should be some small-effect QTL whose contributions to CIA were not big enough to reach the significant threshold value of linkage.
T7163 333-340 RB denotes However
T7165 340-342 , denotes ,
T7166 342-346 NN denotes Cia2
T7164 347-358 VBD denotes contributed
T7167 359-361 IN denotes to
T7168 362-366 RB denotes only
T7170 367-369 CD denotes 16
T7169 369-370 NN denotes %
T7171 371-373 IN denotes of
T7172 374-377 DT denotes the
T7174 378-387 NN denotes phenotype
T7173 388-398 NNS denotes variations
T7175 398-400 , denotes ,
T7176 400-410 VBG denotes indicating
T7177 411-415 IN denotes that
T7179 416-421 EX denotes there
T7180 422-428 MD denotes should
T7178 429-431 VB denotes be
T7181 432-436 DT denotes some
T7183 437-442 JJ denotes small
T7185 442-443 HYPH denotes -
T7184 443-449 NN denotes effect
T7182 450-453 NNS denotes QTL
T7186 454-459 WP$ denotes whose
T7187 460-473 NNS denotes contributions
T7189 474-476 IN denotes to
T7190 477-480 NN denotes CIA
T7188 481-485 VBD denotes were
T7191 486-489 RB denotes not
T7192 490-493 JJ denotes big
T7193 494-500 RB denotes enough
T7194 501-503 TO denotes to
T7195 504-509 VB denotes reach
T7196 510-513 DT denotes the
T7198 514-525 JJ denotes significant
T7199 526-535 NN denotes threshold
T7197 536-541 NN denotes value
T7200 542-544 IN denotes of
T7201 545-552 NN denotes linkage
T7202 552-553 . denotes .
T7203 553-675 sentence denotes To identify these potential small-effect QTL, we reanalyzed the data using a lower threshold value of linkage (P = 0.05).
T7204 554-556 TO denotes To
T7205 557-565 VB denotes identify
T7207 566-571 DT denotes these
T7209 572-581 JJ denotes potential
T7210 582-587 JJ denotes small
T7212 587-588 HYPH denotes -
T7211 588-594 NN denotes effect
T7208 595-598 NNS denotes QTL
T7213 598-600 , denotes ,
T7214 600-602 PRP denotes we
T7206 603-613 VBD denotes reanalyzed
T7215 614-617 DT denotes the
T7216 618-622 NNS denotes data
T7217 623-628 VBG denotes using
T7218 629-630 DT denotes a
T7220 631-636 JJR denotes lower
T7221 637-646 NN denotes threshold
T7219 647-652 NN denotes value
T7222 653-655 IN denotes of
T7223 656-663 NN denotes linkage
T7224 664-665 -LRB- denotes (
T7226 665-666 NN denotes P
T7227 667-668 SYM denotes =
T7225 669-673 CD denotes 0.05
T7228 673-674 -RRB- denotes )
T7229 674-675 . denotes .
T7230 675-909 sentence denotes We reasoned that since the main candidate gene of Cia2, complement component C5 (Hc), was proven to be essential for CIA development and because the FVB/N strain is C5 deficient [10,25], some small-effect QTL might be masked by Cia2.
T7231 676-678 PRP denotes We
T7232 679-687 VBD denotes reasoned
T7233 688-692 IN denotes that
T7235 693-698 IN denotes since
T7237 699-702 DT denotes the
T7239 703-707 JJ denotes main
T7240 708-717 NN denotes candidate
T7238 718-722 NN denotes gene
T7241 723-725 IN denotes of
T7242 726-730 NN denotes Cia2
T7243 730-732 , denotes ,
T7244 732-742 NN denotes complement
T7246 743-752 NN denotes component
T7245 753-755 NN denotes C5
T7247 756-757 -LRB- denotes (
T7248 757-759 NN denotes Hc
T7249 759-760 -RRB- denotes )
T7250 760-762 , denotes ,
T7251 762-765 VBD denotes was
T7236 766-772 VBN denotes proven
T7252 773-775 TO denotes to
T7253 776-778 VB denotes be
T7254 779-788 JJ denotes essential
T7255 789-792 IN denotes for
T7256 793-796 NN denotes CIA
T7257 797-808 NN denotes development
T7258 809-812 CC denotes and
T7259 813-820 IN denotes because
T7261 821-824 DT denotes the
T7263 825-828 NN denotes FVB
T7265 828-829 HYPH denotes /
T7264 829-830 NN denotes N
T7262 831-837 NN denotes strain
T7260 838-840 VBZ denotes is
T7266 841-843 NN denotes C5
T7267 844-853 JJ denotes deficient
T7268 854-855 -LRB- denotes [
T7270 855-857 CD denotes 10
T7271 857-858 , denotes ,
T7269 858-860 CD denotes 25
T7272 860-861 -RRB- denotes ]
T7273 861-863 , denotes ,
T7274 863-867 DT denotes some
T7276 868-873 JJ denotes small
T7278 873-874 HYPH denotes -
T7277 874-880 NN denotes effect
T7275 881-884 NNS denotes QTL
T7279 885-890 MD denotes might
T7280 891-893 VB denotes be
T7234 894-900 VBN denotes masked
T7281 901-903 IN denotes by
T7282 904-908 NN denotes Cia2
T7283 908-909 . denotes .
T7284 909-1101 sentence denotes To exclude the masking effect of C5, we performed linkage analysis with 3 datasets, the first containing all 290 F2 progeny, the second 77 C5+/+ F2 progeny and the third 133 C5+/- F2 progeny.
T7285 910-912 TO denotes To
T7286 913-920 VB denotes exclude
T7288 921-924 DT denotes the
T7290 925-932 NN denotes masking
T7289 933-939 NN denotes effect
T7291 940-942 IN denotes of
T7292 943-945 NN denotes C5
T7293 945-947 , denotes ,
T7294 947-949 PRP denotes we
T7287 950-959 VBD denotes performed
T7295 960-967 NN denotes linkage
T7296 968-976 NN denotes analysis
T7297 977-981 IN denotes with
T7298 982-983 CD denotes 3
T7299 984-992 NNS denotes datasets
T7300 992-994 , denotes ,
T7301 994-997 DT denotes the
T7302 998-1003 JJ denotes first
T7303 1004-1014 VBG denotes containing
T7304 1015-1018 DT denotes all
T7306 1019-1022 CD denotes 290
T7307 1023-1025 NN denotes F2
T7305 1026-1033 NN denotes progeny
T7308 1033-1035 , denotes ,
T7309 1035-1038 DT denotes the
T7310 1039-1045 JJ denotes second
T7312 1046-1048 CD denotes 77
T7313 1049-1052 NN denotes C5+
T7314 1052-1053 HYPH denotes /
T7315 1053-1054 SYM denotes +
T7316 1055-1057 NN denotes F2
T7311 1058-1065 NN denotes progeny
T7317 1066-1069 CC denotes and
T7318 1070-1073 DT denotes the
T7319 1074-1079 JJ denotes third
T7321 1080-1083 CD denotes 133
T7322 1084-1087 NN denotes C5+
T7323 1087-1088 HYPH denotes /
T7324 1088-1089 SYM denotes -
T7325 1090-1092 NN denotes F2
T7320 1093-1100 NN denotes progeny
T7326 1100-1101 . denotes .
T7327 1101-1239 sentence denotes Eight genomic regions were linked to the phenotype of CIA severity (loci 1 to 8, Table 2), with P values varying between 0.043 and 0.003.
T7328 1102-1107 CD denotes Eight
T7330 1108-1115 JJ denotes genomic
T7329 1116-1123 NNS denotes regions
T7332 1124-1128 VBD denotes were
T7331 1129-1135 VBN denotes linked
T7333 1136-1138 IN denotes to
T7334 1139-1142 DT denotes the
T7335 1143-1152 NN denotes phenotype
T7336 1153-1155 IN denotes of
T7337 1156-1159 NN denotes CIA
T7338 1160-1168 NN denotes severity
T7339 1169-1170 -LRB- denotes (
T7341 1170-1174 NNS denotes loci
T7342 1175-1176 CD denotes 1
T7343 1177-1179 IN denotes to
T7344 1180-1181 CD denotes 8
T7345 1181-1183 , denotes ,
T7340 1183-1188 NN denotes Table
T7346 1189-1190 CD denotes 2
T7347 1190-1191 -RRB- denotes )
T7348 1191-1193 , denotes ,
T7349 1193-1197 IN denotes with
T7351 1198-1199 NN denotes P
T7352 1200-1206 NNS denotes values
T7350 1207-1214 VBG denotes varying
T7353 1215-1222 IN denotes between
T7354 1223-1228 CD denotes 0.043
T7355 1229-1232 CC denotes and
T7356 1233-1238 CD denotes 0.003
T7357 1238-1239 . denotes .
T7358 1239-1325 sentence denotes These eight small-effect QTL were located on chromosomes 5, 6, 7, 10, 11, 16, and 17.
T7359 1240-1245 DT denotes These
T7361 1246-1251 CD denotes eight
T7362 1252-1257 JJ denotes small
T7364 1257-1258 HYPH denotes -
T7363 1258-1264 NN denotes effect
T7360 1265-1268 NNS denotes QTL
T7366 1269-1273 VBD denotes were
T7365 1274-1281 VBN denotes located
T7367 1282-1284 IN denotes on
T7368 1285-1296 NNS denotes chromosomes
T7369 1297-1298 CD denotes 5
T7370 1298-1300 , denotes ,
T7371 1300-1301 CD denotes 6
T7372 1301-1303 , denotes ,
T7373 1303-1304 CD denotes 7
T7374 1304-1306 , denotes ,
T7375 1306-1308 CD denotes 10
T7376 1308-1310 , denotes ,
T7377 1310-1312 CD denotes 11
T7378 1312-1314 , denotes ,
T7379 1314-1316 CD denotes 16
T7380 1316-1318 , denotes ,
T7381 1318-1321 CC denotes and
T7382 1322-1324 CD denotes 17
T7383 1324-1325 . denotes .
T7384 1325-1377 sentence denotes Five loci were identified in at least two datasets.
T7385 1326-1330 CD denotes Five
T7386 1331-1335 NNS denotes loci
T7388 1336-1340 VBD denotes were
T7387 1341-1351 VBN denotes identified
T7389 1352-1354 IN denotes in
T7390 1355-1357 RB denotes at
T7392 1358-1363 RBS denotes least
T7391 1364-1367 CD denotes two
T7393 1368-1376 NNS denotes datasets
T7394 1376-1377 . denotes .
T7395 1377-1491 sentence denotes Of the eight loci, five had DBA/1 as the susceptibility allele, and three had FVB/N as the susceptibility allele.
T7396 1378-1380 IN denotes Of
T7398 1381-1384 DT denotes the
T7400 1385-1390 CD denotes eight
T7399 1391-1395 NNS denotes loci
T7401 1395-1397 , denotes ,
T7402 1397-1401 CD denotes five
T7397 1402-1405 VBD denotes had
T7403 1406-1409 NN denotes DBA
T7404 1409-1410 HYPH denotes /
T7405 1410-1411 CD denotes 1
T7406 1412-1414 IN denotes as
T7407 1415-1418 DT denotes the
T7409 1419-1433 NN denotes susceptibility
T7408 1434-1440 NN denotes allele
T7410 1440-1442 , denotes ,
T7411 1442-1445 CC denotes and
T7412 1446-1451 CD denotes three
T7413 1452-1455 VBD denotes had
T7414 1456-1459 NN denotes FVB
T7416 1459-1460 HYPH denotes /
T7415 1460-1461 NN denotes N
T7417 1462-1464 IN denotes as
T7418 1465-1468 DT denotes the
T7420 1469-1483 NN denotes susceptibility
T7419 1484-1490 NN denotes allele
T7421 1490-1491 . denotes .
T7422 1491-1733 sentence denotes Lander and Botstein [26] suggested a LOD score of between 2 and 3 to ensure an overall false positive rate of 5%, which means that using a lower threshold value will prevent false negative QTL at the expense of increasing false positive QTL.
T7423 1492-1498 NNP denotes Lander
T7425 1499-1502 CC denotes and
T7426 1503-1511 NNP denotes Botstein
T7427 1512-1513 -LRB- denotes [
T7428 1513-1515 CD denotes 26
T7429 1515-1516 -RRB- denotes ]
T7424 1517-1526 VBD denotes suggested
T7430 1527-1528 DT denotes a
T7432 1529-1532 NN denotes LOD
T7431 1533-1538 NN denotes score
T7433 1539-1541 IN denotes of
T7434 1542-1549 IN denotes between
T7435 1550-1551 CD denotes 2
T7436 1552-1555 CC denotes and
T7437 1556-1557 CD denotes 3
T7438 1558-1560 TO denotes to
T7439 1561-1567 VB denotes ensure
T7440 1568-1570 DT denotes an
T7442 1571-1578 JJ denotes overall
T7443 1579-1584 JJ denotes false
T7444 1585-1593 JJ denotes positive
T7441 1594-1598 NN denotes rate
T7445 1599-1601 IN denotes of
T7446 1602-1603 CD denotes 5
T7447 1603-1604 NN denotes %
T7448 1604-1606 , denotes ,
T7449 1606-1611 WDT denotes which
T7450 1612-1617 VBZ denotes means
T7451 1618-1622 IN denotes that
T7453 1623-1628 VBG denotes using
T7454 1629-1630 DT denotes a
T7456 1631-1636 JJR denotes lower
T7457 1637-1646 NN denotes threshold
T7455 1647-1652 NN denotes value
T7458 1653-1657 MD denotes will
T7452 1658-1665 VB denotes prevent
T7459 1666-1671 JJ denotes false
T7460 1672-1680 JJ denotes negative
T7461 1681-1684 NNS denotes QTL
T7462 1685-1687 IN denotes at
T7463 1688-1691 DT denotes the
T7464 1692-1699 NN denotes expense
T7465 1700-1702 IN denotes of
T7466 1703-1713 VBG denotes increasing
T7467 1714-1719 JJ denotes false
T7468 1720-1728 JJ denotes positive
T7469 1729-1732 NNS denotes QTL
T7470 1732-1733 . denotes .
T7471 1733-1909 sentence denotes Being aware of this, we examined these genomic regions to search whether they, or their syntenic genomic regions on the human genome, have been previously linked to arthritis.
T7472 1734-1739 VBG denotes Being
T7474 1740-1745 JJ denotes aware
T7475 1746-1748 IN denotes of
T7476 1749-1753 DT denotes this
T7477 1753-1755 , denotes ,
T7478 1755-1757 PRP denotes we
T7473 1758-1766 VBD denotes examined
T7479 1767-1772 DT denotes these
T7481 1773-1780 JJ denotes genomic
T7480 1781-1788 NNS denotes regions
T7482 1789-1791 TO denotes to
T7483 1792-1798 VB denotes search
T7484 1799-1806 IN denotes whether
T7486 1807-1811 PRP denotes they
T7487 1811-1813 , denotes ,
T7488 1813-1815 CC denotes or
T7489 1816-1821 PRP$ denotes their
T7491 1822-1830 JJ denotes syntenic
T7492 1831-1838 JJ denotes genomic
T7490 1839-1846 NNS denotes regions
T7493 1847-1849 IN denotes on
T7494 1850-1853 DT denotes the
T7496 1854-1859 JJ denotes human
T7495 1860-1866 NN denotes genome
T7497 1866-1868 , denotes ,
T7498 1868-1872 VBP denotes have
T7499 1873-1877 VBN denotes been
T7500 1878-1888 RB denotes previously
T7485 1889-1895 VBN denotes linked
T7501 1896-1898 IN denotes to
T7502 1899-1908 NN denotes arthritis
T7503 1908-1909 . denotes .
T7504 1909-2004 sentence denotes Four small-effect QTL overlapped with arthritis QTL on the mouse genome identified previously.
T7505 1910-1914 CD denotes Four
T7507 1915-1920 JJ denotes small
T7509 1920-1921 HYPH denotes -
T7508 1921-1927 NN denotes effect
T7506 1928-1931 NNS denotes QTL
T7510 1932-1942 VBD denotes overlapped
T7511 1943-1947 IN denotes with
T7512 1948-1957 NN denotes arthritis
T7513 1958-1961 NNS denotes QTL
T7514 1962-1964 IN denotes on
T7515 1965-1968 DT denotes the
T7517 1969-1974 NN denotes mouse
T7516 1975-1981 NN denotes genome
T7518 1982-1992 VBN denotes identified
T7519 1993-2003 RB denotes previously
T7520 2003-2004 . denotes .
T7521 2004-2115 sentence denotes Locus 1 and 2 overlap with Cia13 and Cia14, which control severity of CIA in (DBA/1 × BALB/C) F2 progeny [27].
T7522 2005-2010 NN denotes Locus
T7523 2011-2012 CD denotes 1
T7525 2013-2016 CC denotes and
T7526 2017-2018 CD denotes 2
T7524 2019-2026 VBP denotes overlap
T7527 2027-2031 IN denotes with
T7528 2032-2037 NN denotes Cia13
T7529 2038-2041 CC denotes and
T7530 2042-2047 NN denotes Cia14
T7531 2047-2049 , denotes ,
T7532 2049-2054 WDT denotes which
T7533 2055-2062 VBP denotes control
T7534 2063-2071 NN denotes severity
T7535 2072-2074 IN denotes of
T7536 2075-2078 NN denotes CIA
T7537 2079-2081 IN denotes in
T7538 2082-2083 -LRB- denotes (
T7539 2083-2086 NN denotes DBA
T7541 2086-2087 HYPH denotes /
T7542 2087-2088 CD denotes 1
T7543 2089-2090 SYM denotes ×
T7544 2091-2095 NN denotes BALB
T7546 2095-2096 HYPH denotes /
T7545 2096-2097 NN denotes C
T7547 2097-2098 -RRB- denotes )
T7548 2099-2101 NN denotes F2
T7540 2102-2109 NN denotes progeny
T7549 2110-2111 -LRB- denotes [
T7550 2111-2113 CD denotes 27
T7551 2113-2114 -RRB- denotes ]
T7552 2114-2115 . denotes .
T7553 2115-2225 sentence denotes Locus 5 located on chromosome 10 overlaps with Cia8, which was identified in (DBA/1 × B10.Q) F2 progeny [28].
T7554 2116-2121 NN denotes Locus
T7556 2122-2123 CD denotes 5
T7557 2124-2131 VBN denotes located
T7558 2132-2134 IN denotes on
T7559 2135-2145 NN denotes chromosome
T7560 2146-2148 CD denotes 10
T7555 2149-2157 VBZ denotes overlaps
T7561 2158-2162 IN denotes with
T7562 2163-2167 NN denotes Cia8
T7563 2167-2169 , denotes ,
T7564 2169-2174 WDT denotes which
T7566 2175-2178 VBD denotes was
T7565 2179-2189 VBN denotes identified
T7567 2190-2192 IN denotes in
T7568 2193-2194 -LRB- denotes (
T7569 2194-2197 NN denotes DBA
T7571 2197-2198 HYPH denotes /
T7572 2198-2199 CD denotes 1
T7573 2200-2201 SYM denotes ×
T7574 2202-2207 NN denotes B10.Q
T7575 2207-2208 -RRB- denotes )
T7576 2209-2211 NN denotes F2
T7570 2212-2219 NN denotes progeny
T7577 2220-2221 -LRB- denotes [
T7578 2221-2223 CD denotes 28
T7579 2223-2224 -RRB- denotes ]
T7580 2224-2225 . denotes .
T7581 2225-2381 sentence denotes Locus 6 overlaps with Pgia7, which controls susceptibility to proteoglycan-induced arthritis (PGIA) and was identified in (BALB/C × DBA/2) F2 progeny [29].
T7582 2226-2231 NN denotes Locus
T7584 2232-2233 CD denotes 6
T7583 2234-2242 VBZ denotes overlaps
T7585 2243-2247 IN denotes with
T7586 2248-2253 NN denotes Pgia7
T7587 2253-2255 , denotes ,
T7588 2255-2260 WDT denotes which
T7589 2261-2269 VBZ denotes controls
T7590 2270-2284 NN denotes susceptibility
T7591 2285-2287 IN denotes to
T7592 2288-2300 NN denotes proteoglycan
T7594 2300-2301 HYPH denotes -
T7593 2301-2308 VBN denotes induced
T7595 2309-2318 NN denotes arthritis
T7596 2319-2320 -LRB- denotes (
T7597 2320-2324 NN denotes PGIA
T7598 2324-2325 -RRB- denotes )
T7599 2326-2329 CC denotes and
T7600 2330-2333 VBD denotes was
T7601 2334-2344 VBN denotes identified
T7602 2345-2347 IN denotes in
T7603 2348-2349 -LRB- denotes (
T7605 2349-2353 NN denotes BALB
T7606 2353-2354 HYPH denotes /
T7604 2354-2355 NN denotes C
T7608 2356-2357 SYM denotes ×
T7609 2358-2361 NN denotes DBA
T7610 2361-2362 HYPH denotes /
T7611 2362-2363 CD denotes 2
T7612 2363-2364 -RRB- denotes )
T7613 2365-2367 NN denotes F2
T7607 2368-2375 NN denotes progeny
T7614 2376-2377 -LRB- denotes [
T7615 2377-2379 CD denotes 29
T7616 2379-2380 -RRB- denotes ]
T7617 2380-2381 . denotes .
T7618 2381-2494 sentence denotes The syntenic genomic regions of five small-effect QTL on the human genome have been reported to be linked to RA.
T7619 2382-2385 DT denotes The
T7621 2386-2394 JJ denotes syntenic
T7622 2395-2402 JJ denotes genomic
T7620 2403-2410 NNS denotes regions
T7624 2411-2413 IN denotes of
T7625 2414-2418 CD denotes five
T7627 2419-2424 JJ denotes small
T7629 2424-2425 HYPH denotes -
T7628 2425-2431 NN denotes effect
T7626 2432-2435 NNS denotes QTL
T7630 2436-2438 IN denotes on
T7631 2439-2442 DT denotes the
T7633 2443-2448 JJ denotes human
T7632 2449-2455 NN denotes genome
T7634 2456-2460 VBP denotes have
T7635 2461-2465 VBN denotes been
T7623 2466-2474 VBN denotes reported
T7636 2475-2477 TO denotes to
T7638 2478-2480 VB denotes be
T7637 2481-2487 VBN denotes linked
T7639 2488-2490 IN denotes to
T7640 2491-2493 NN denotes RA
T7641 2493-2494 . denotes .
T7642 2494-2853 sentence denotes These are genomic regions 22q11 and 12p13-q24 on chromosome 22 and 12 (the counterparts of locus 2), 12p13-pter on chromosome 12 (the counterpart of locus 3), 21q22-qter and 10q22-23 on chromosome 21 and 10 (the counterparts of locus 5), 17q21-25 on chromosome 17 (the counterpart of locus 6) and 3q29-qter on chromosome 3 (the counterpart of locus 7) [2,4].
T7643 2495-2500 DT denotes These
T7644 2501-2504 VBP denotes are
T7645 2505-2512 JJ denotes genomic
T7646 2513-2520 NNS denotes regions
T7647 2521-2526 NN denotes 22q11
T7648 2527-2530 CC denotes and
T7649 2531-2536 NN denotes 12p13
T7651 2536-2537 HYPH denotes -
T7650 2537-2540 NN denotes q24
T7652 2541-2543 IN denotes on
T7653 2544-2554 NN denotes chromosome
T7654 2555-2557 CD denotes 22
T7655 2558-2561 CC denotes and
T7656 2562-2564 CD denotes 12
T7657 2565-2566 -LRB- denotes (
T7659 2566-2569 DT denotes the
T7658 2570-2582 NNS denotes counterparts
T7660 2583-2585 IN denotes of
T7661 2586-2591 NN denotes locus
T7662 2592-2593 CD denotes 2
T7663 2593-2594 -RRB- denotes )
T7664 2594-2596 , denotes ,
T7665 2596-2601 NN denotes 12p13
T7667 2601-2602 HYPH denotes -
T7666 2602-2606 NN denotes pter
T7668 2607-2609 IN denotes on
T7669 2610-2620 NN denotes chromosome
T7670 2621-2623 CD denotes 12
T7671 2624-2625 -LRB- denotes (
T7673 2625-2628 DT denotes the
T7672 2629-2640 NN denotes counterpart
T7674 2641-2643 IN denotes of
T7675 2644-2649 NN denotes locus
T7676 2650-2651 CD denotes 3
T7677 2651-2652 -RRB- denotes )
T7678 2652-2654 , denotes ,
T7679 2654-2659 NN denotes 21q22
T7681 2659-2660 HYPH denotes -
T7680 2660-2664 NN denotes qter
T7682 2665-2668 CC denotes and
T7683 2669-2674 NN denotes 10q22
T7684 2674-2675 HYPH denotes -
T7685 2675-2677 CD denotes 23
T7686 2678-2680 IN denotes on
T7687 2681-2691 NN denotes chromosome
T7688 2692-2694 CD denotes 21
T7689 2695-2698 CC denotes and
T7690 2699-2701 CD denotes 10
T7691 2702-2703 -LRB- denotes (
T7693 2703-2706 DT denotes the
T7692 2707-2719 NNS denotes counterparts
T7694 2720-2722 IN denotes of
T7695 2723-2728 NN denotes locus
T7696 2729-2730 CD denotes 5
T7697 2730-2731 -RRB- denotes )
T7698 2731-2733 , denotes ,
T7699 2733-2738 NN denotes 17q21
T7700 2738-2739 HYPH denotes -
T7701 2739-2741 CD denotes 25
T7702 2742-2744 IN denotes on
T7703 2745-2755 NN denotes chromosome
T7704 2756-2758 CD denotes 17
T7705 2759-2760 -LRB- denotes (
T7707 2760-2763 DT denotes the
T7706 2764-2775 NN denotes counterpart
T7708 2776-2778 IN denotes of
T7709 2779-2784 NN denotes locus
T7710 2785-2786 CD denotes 6
T7711 2786-2787 -RRB- denotes )
T7712 2788-2791 CC denotes and
T7713 2792-2796 NN denotes 3q29
T7715 2796-2797 HYPH denotes -
T7714 2797-2801 NN denotes qter
T7716 2802-2804 IN denotes on
T7717 2805-2815 NN denotes chromosome
T7718 2816-2817 CD denotes 3
T7719 2818-2819 -LRB- denotes (
T7721 2819-2822 DT denotes the
T7720 2823-2834 NN denotes counterpart
T7722 2835-2837 IN denotes of
T7723 2838-2843 NN denotes locus
T7724 2844-2845 CD denotes 7
T7725 2845-2846 -RRB- denotes )
T7726 2847-2848 -LRB- denotes [
T7728 2848-2849 CD denotes 2
T7729 2849-2850 , denotes ,
T7727 2850-2851 CD denotes 4
T7730 2851-2852 -RRB- denotes ]
T7731 2852-2853 . denotes .
R1824 T7078 T7079 amod Small,effect
R1825 T7079 T7081 compound effect,QTL
R1826 T7080 T7079 punct -,effect
R1827 T7082 T7081 prep of,QTL
R1828 T7083 T7082 pobj CIA,of
R1829 T7084 T7081 prep in,QTL
R1830 T7085 T7086 punct (,DBA
R1831 T7086 T7087 nmod DBA,progeny
R1832 T7087 T7084 pobj progeny,in
R1833 T7088 T7086 punct /,DBA
R1834 T7089 T7086 nummod 1,DBA
R1835 T7090 T7086 punct ×,DBA
R1836 T7091 T7092 compound FVB,N
R1837 T7092 T7086 appos N,DBA
R1838 T7093 T7092 punct /,N
R1839 T7094 T7086 punct ),DBA
R1840 T7095 T7087 compound F2,progeny
R1841 T7097 T7098 prep In,carried
R1842 T7099 T7100 det a,study
R1843 T7100 T7097 pobj study,In
R1844 T7101 T7100 amod previous,study
R1845 T7102 T7098 punct ", ",carried
R1846 T7103 T7098 nsubj we,carried
R1847 T7104 T7098 prt out,carried
R1848 T7105 T7106 det a,screen
R1849 T7106 T7098 dobj screen,carried
R1850 T7107 T7106 compound genome,screen
R1851 T7108 T7109 aux to,identify
R1852 T7109 T7098 advcl identify,carried
R1853 T7110 T7109 dobj QTL,identify
R1854 T7111 T7110 acl controlling,QTL
R1855 T7112 T7113 compound CIA,susceptibility
R1856 T7113 T7111 dobj susceptibility,controlling
R1857 T7114 T7111 prep in,controlling
R1858 T7115 T7116 punct (,DBA
R1859 T7116 T7117 nmod DBA,progeny
R1860 T7117 T7114 pobj progeny,in
R1861 T7118 T7116 punct /,DBA
R1862 T7119 T7116 nummod 1,DBA
R1863 T7120 T7121 punct ×,N
R1864 T7121 T7116 prep N,DBA
R1865 T7122 T7121 compound FVB,N
R1866 T7123 T7121 punct /,N
R1867 T7124 T7116 punct ),DBA
R1868 T7125 T7117 compound F2,progeny
R1869 T7126 T7098 punct .,carried
R1870 T7128 T7129 prep For,identified
R1871 T7130 T7131 det the,phenotype
R1872 T7131 T7128 pobj phenotype,For
R1873 T7132 T7131 prep of,phenotype
R1874 T7133 T7134 compound arthritis,severity
R1875 T7134 T7132 pobj severity,of
R1876 T7135 T7129 punct ", ",identified
R1877 T7136 T7137 advmod only,QTL
R1878 T7137 T7129 nsubjpass QTL,identified
R1879 T7138 T7137 nummod one,QTL
R1880 T7139 T7137 punct ", ",QTL
R1881 T7140 T7137 appos Cia2,QTL
R1882 T7141 T7129 punct ", ",identified
R1883 T7142 T7129 auxpass was,identified
R1884 T7143 T7129 punct ", ",identified
R1885 T7144 T7129 prep with,identified
R1886 T7145 T7146 det a,score
R1887 T7146 T7144 pobj score,with
R1888 T7147 T7148 advmod highly,significant
R1889 T7148 T7146 amod significant,score
R1890 T7149 T7146 nmod logarithm,score
R1891 T7150 T7149 prep of,logarithm
R1892 T7151 T7152 det the,odds
R1893 T7152 T7150 pobj odds,of
R1894 T7153 T7149 punct (,logarithm
R1895 T7154 T7149 appos LOD,logarithm
R1896 T7155 T7146 punct ),score
R1897 T7156 T7146 prep of,score
R1898 T7157 T7156 pobj 12,of
R1899 T7158 T7159 punct [,10
R1900 T7159 T7129 parataxis 10,identified
R1901 T7160 T7159 punct ],10
R1902 T7161 T7129 punct .,identified
R1903 T7163 T7164 advmod However,contributed
R1904 T7165 T7164 punct ", ",contributed
R1905 T7166 T7164 nsubj Cia2,contributed
R1906 T7167 T7164 prep to,contributed
R1907 T7168 T7169 advmod only,%
R1908 T7169 T7167 pobj %,to
R1909 T7170 T7169 nummod 16,%
R1910 T7171 T7169 prep of,%
R1911 T7172 T7173 det the,variations
R1912 T7173 T7171 pobj variations,of
R1913 T7174 T7173 compound phenotype,variations
R1914 T7175 T7164 punct ", ",contributed
R1915 T7176 T7164 advcl indicating,contributed
R1916 T7177 T7178 mark that,be
R1917 T7178 T7176 ccomp be,indicating
R1918 T7179 T7178 expl there,be
R1919 T7180 T7178 aux should,be
R1920 T7181 T7182 det some,QTL
R1921 T7182 T7178 attr QTL,be
R1922 T7183 T7184 amod small,effect
R1923 T7184 T7182 compound effect,QTL
R1924 T7185 T7184 punct -,effect
R1925 T7186 T7187 poss whose,contributions
R1926 T7187 T7188 dep contributions,were
R1927 T7188 T7182 relcl were,QTL
R1928 T7189 T7187 prep to,contributions
R1929 T7190 T7189 pobj CIA,to
R1930 T7191 T7188 neg not,were
R1931 T7192 T7188 acomp big,were
R1932 T7193 T7192 advmod enough,big
R1933 T7194 T7195 aux to,reach
R1934 T7195 T7192 xcomp reach,big
R1935 T7196 T7197 det the,value
R1936 T7197 T7195 dobj value,reach
R1937 T7198 T7199 amod significant,threshold
R1938 T7199 T7197 compound threshold,value
R1939 T7200 T7197 prep of,value
R1940 T7201 T7200 pobj linkage,of
R1941 T7202 T7164 punct .,contributed
R1942 T7204 T7205 aux To,identify
R1943 T7205 T7206 advcl identify,reanalyzed
R1944 T7207 T7208 det these,QTL
R1945 T7208 T7205 dobj QTL,identify
R1946 T7209 T7208 amod potential,QTL
R1947 T7210 T7211 amod small,effect
R1948 T7211 T7208 compound effect,QTL
R1949 T7212 T7211 punct -,effect
R1950 T7213 T7206 punct ", ",reanalyzed
R1951 T7214 T7206 nsubj we,reanalyzed
R1952 T7215 T7216 det the,data
R1953 T7216 T7206 dobj data,reanalyzed
R1954 T7217 T7206 advcl using,reanalyzed
R1955 T7218 T7219 det a,value
R1956 T7219 T7217 dobj value,using
R1957 T7220 T7221 amod lower,threshold
R1958 T7221 T7219 compound threshold,value
R1959 T7222 T7219 prep of,value
R1960 T7223 T7222 pobj linkage,of
R1961 T7224 T7225 punct (,0.05
R1962 T7225 T7219 parataxis 0.05,value
R1963 T7226 T7225 nsubj P,0.05
R1964 T7227 T7225 punct =,0.05
R1965 T7228 T7225 punct ),0.05
R1966 T7229 T7206 punct .,reanalyzed
R1967 T7231 T7232 nsubj We,reasoned
R1968 T7233 T7234 mark that,masked
R1969 T7234 T7232 ccomp masked,reasoned
R1970 T7235 T7236 mark since,proven
R1971 T7236 T7234 advcl proven,masked
R1972 T7237 T7238 det the,gene
R1973 T7238 T7236 nsubjpass gene,proven
R1974 T7239 T7238 amod main,gene
R1975 T7240 T7238 compound candidate,gene
R1976 T7241 T7238 prep of,gene
R1977 T7242 T7241 pobj Cia2,of
R1978 T7243 T7238 punct ", ",gene
R1979 T7244 T7245 compound complement,C5
R1980 T7245 T7238 appos C5,gene
R1981 T7246 T7245 compound component,C5
R1982 T7247 T7248 punct (,Hc
R1983 T7248 T7245 parataxis Hc,C5
R1984 T7249 T7248 punct ),Hc
R1985 T7250 T7236 punct ", ",proven
R1986 T7251 T7236 auxpass was,proven
R1987 T7252 T7253 aux to,be
R1988 T7253 T7236 xcomp be,proven
R1989 T7254 T7253 acomp essential,be
R1990 T7255 T7254 prep for,essential
R1991 T7256 T7257 compound CIA,development
R1992 T7257 T7255 pobj development,for
R1993 T7258 T7236 cc and,proven
R1994 T7259 T7260 mark because,is
R1995 T7260 T7236 conj is,proven
R1996 T7261 T7262 det the,strain
R1997 T7262 T7260 nsubj strain,is
R1998 T7263 T7264 compound FVB,N
R1999 T7264 T7262 compound N,strain
R2000 T7265 T7264 punct /,N
R2001 T7266 T7267 npadvmod C5,deficient
R2002 T7267 T7260 acomp deficient,is
R2003 T7268 T7269 punct [,25
R2004 T7269 T7260 parataxis 25,is
R2005 T7270 T7269 nummod 10,25
R2006 T7271 T7269 punct ",",25
R2007 T7272 T7269 punct ],25
R2008 T7273 T7234 punct ", ",masked
R2009 T7274 T7275 det some,QTL
R2010 T7275 T7234 nsubjpass QTL,masked
R2011 T7276 T7277 amod small,effect
R2012 T7277 T7275 compound effect,QTL
R2013 T7278 T7277 punct -,effect
R2014 T7279 T7234 aux might,masked
R2015 T7280 T7234 auxpass be,masked
R2016 T7281 T7234 agent by,masked
R2017 T7282 T7281 pobj Cia2,by
R2018 T7283 T7232 punct .,reasoned
R2019 T7285 T7286 aux To,exclude
R2020 T7286 T7287 advcl exclude,performed
R2021 T7288 T7289 det the,effect
R2022 T7289 T7286 dobj effect,exclude
R2023 T7290 T7289 compound masking,effect
R2024 T7291 T7289 prep of,effect
R2025 T7292 T7291 pobj C5,of
R2026 T7293 T7287 punct ", ",performed
R2027 T7294 T7287 nsubj we,performed
R2028 T7295 T7296 compound linkage,analysis
R2029 T7296 T7287 dobj analysis,performed
R2030 T7297 T7287 prep with,performed
R2031 T7298 T7299 nummod 3,datasets
R2032 T7299 T7297 pobj datasets,with
R2033 T7300 T7287 punct ", ",performed
R2034 T7301 T7302 det the,first
R2035 T7302 T7303 nsubj first,containing
R2036 T7303 T7287 advcl containing,performed
R2037 T7304 T7305 det all,progeny
R2038 T7305 T7303 dobj progeny,containing
R2039 T7306 T7305 nummod 290,progeny
R2040 T7307 T7305 compound F2,progeny
R2041 T7308 T7303 punct ", ",containing
R2042 T7309 T7310 det the,second
R2043 T7310 T7311 nsubj second,progeny
R2044 T7311 T7303 conj progeny,containing
R2045 T7312 T7311 nummod 77,progeny
R2046 T7313 T7311 nmod C5+,progeny
R2047 T7314 T7313 punct /,C5+
R2048 T7315 T7313 punct +,C5+
R2049 T7316 T7311 compound F2,progeny
R2050 T7317 T7311 cc and,progeny
R2051 T7318 T7319 det the,third
R2052 T7319 T7320 nsubj third,progeny
R2053 T7320 T7311 conj progeny,progeny
R2054 T7321 T7320 nummod 133,progeny
R2055 T7322 T7320 nmod C5+,progeny
R2056 T7323 T7322 punct /,C5+
R2057 T7324 T7322 punct -,C5+
R2058 T7325 T7320 compound F2,progeny
R2059 T7326 T7287 punct .,performed
R2060 T7328 T7329 nummod Eight,regions
R2061 T7329 T7331 nsubjpass regions,linked
R2062 T7330 T7329 amod genomic,regions
R2063 T7332 T7331 auxpass were,linked
R2064 T7333 T7331 prep to,linked
R2065 T7334 T7335 det the,phenotype
R2066 T7335 T7333 pobj phenotype,to
R2067 T7336 T7335 prep of,phenotype
R2068 T7337 T7338 compound CIA,severity
R2069 T7338 T7336 pobj severity,of
R2070 T7339 T7340 punct (,Table
R2071 T7340 T7331 parataxis Table,linked
R2072 T7341 T7342 nmod loci,1
R2073 T7342 T7340 dep 1,Table
R2074 T7343 T7342 prep to,1
R2075 T7344 T7343 pobj 8,to
R2076 T7345 T7340 punct ", ",Table
R2077 T7346 T7340 nummod 2,Table
R2078 T7347 T7340 punct ),Table
R2079 T7348 T7331 punct ", ",linked
R2080 T7349 T7350 mark with,varying
R2081 T7350 T7331 advcl varying,linked
R2082 T7351 T7352 compound P,values
R2083 T7352 T7350 nsubj values,varying
R2084 T7353 T7350 prep between,varying
R2085 T7354 T7353 pobj 0.043,between
R2086 T7355 T7354 cc and,0.043
R2087 T7356 T7354 conj 0.003,0.043
R2088 T7357 T7331 punct .,linked
R2089 T7359 T7360 det These,QTL
R2090 T7360 T7365 nsubjpass QTL,located
R2091 T7361 T7360 nummod eight,QTL
R2092 T7362 T7363 amod small,effect
R2093 T7363 T7360 compound effect,QTL
R2094 T7364 T7363 punct -,effect
R2095 T7366 T7365 auxpass were,located
R2096 T7367 T7365 prep on,located
R2097 T7368 T7369 nmod chromosomes,5
R2098 T7369 T7367 pobj 5,on
R2099 T7370 T7369 punct ", ",5
R2100 T7371 T7369 conj 6,5
R2101 T7372 T7371 punct ", ",6
R2102 T7373 T7371 conj 7,6
R2103 T7374 T7373 punct ", ",7
R2104 T7375 T7373 conj 10,7
R2105 T7376 T7375 punct ", ",10
R2106 T7377 T7375 conj 11,10
R2107 T7378 T7377 punct ", ",11
R2108 T7379 T7377 conj 16,11
R2109 T7380 T7379 punct ", ",16
R2110 T7381 T7379 cc and,16
R2111 T7382 T7379 conj 17,16
R2112 T7383 T7365 punct .,located
R2113 T7385 T7386 nummod Five,loci
R2114 T7386 T7387 nsubjpass loci,identified
R2115 T7388 T7387 auxpass were,identified
R2116 T7389 T7387 prep in,identified
R2117 T7390 T7391 advmod at,two
R2118 T7391 T7393 nummod two,datasets
R2119 T7392 T7391 advmod least,two
R2120 T7393 T7389 pobj datasets,in
R2121 T7394 T7387 punct .,identified
R2122 T7396 T7397 prep Of,had
R2123 T7398 T7399 det the,loci
R2124 T7399 T7396 pobj loci,Of
R2125 T7400 T7399 nummod eight,loci
R2126 T7401 T7397 punct ", ",had
R2127 T7402 T7397 nsubj five,had
R2128 T7403 T7397 dobj DBA,had
R2129 T7404 T7403 punct /,DBA
R2130 T7405 T7403 nummod 1,DBA
R2131 T7406 T7397 prep as,had
R2132 T7407 T7408 det the,allele
R2133 T7408 T7406 pobj allele,as
R2134 T7409 T7408 compound susceptibility,allele
R2135 T7410 T7397 punct ", ",had
R2136 T7411 T7397 cc and,had
R2137 T7412 T7413 nsubj three,had
R2138 T7413 T7397 conj had,had
R2139 T7414 T7415 compound FVB,N
R2140 T7415 T7413 dobj N,had
R2141 T7416 T7415 punct /,N
R2142 T7417 T7413 prep as,had
R2143 T7418 T7419 det the,allele
R2144 T7419 T7417 pobj allele,as
R2145 T7420 T7419 compound susceptibility,allele
R2146 T7421 T7397 punct .,had
R2147 T7423 T7424 nsubj Lander,suggested
R2148 T7425 T7423 cc and,Lander
R2149 T7426 T7423 conj Botstein,Lander
R2150 T7427 T7428 punct [,26
R2151 T7428 T7426 parataxis 26,Botstein
R2152 T7429 T7428 punct ],26
R2153 T7430 T7431 det a,score
R2154 T7431 T7424 dobj score,suggested
R2155 T7432 T7431 compound LOD,score
R2156 T7433 T7431 prep of,score
R2157 T7434 T7435 quantmod between,2
R2158 T7435 T7433 pobj 2,of
R2159 T7436 T7435 cc and,2
R2160 T7437 T7435 conj 3,2
R2161 T7438 T7439 aux to,ensure
R2162 T7439 T7424 advcl ensure,suggested
R2163 T7440 T7441 det an,rate
R2164 T7441 T7439 dobj rate,ensure
R2165 T7442 T7441 amod overall,rate
R2166 T7443 T7444 amod false,positive
R2167 T7444 T7441 amod positive,rate
R2168 T7445 T7441 prep of,rate
R2169 T7446 T7447 nummod 5,%
R2170 T7447 T7445 pobj %,of
R2171 T7448 T7424 punct ", ",suggested
R2172 T7449 T7450 dep which,means
R2173 T7450 T7424 advcl means,suggested
R2174 T7451 T7452 mark that,prevent
R2175 T7452 T7450 ccomp prevent,means
R2176 T7453 T7452 csubj using,prevent
R2177 T7454 T7455 det a,value
R2178 T7455 T7453 dobj value,using
R2179 T7456 T7455 amod lower,value
R2180 T7457 T7455 compound threshold,value
R2181 T7458 T7452 aux will,prevent
R2182 T7459 T7460 amod false,negative
R2183 T7460 T7461 amod negative,QTL
R2184 T7461 T7452 dobj QTL,prevent
R2185 T7462 T7452 prep at,prevent
R2186 T7463 T7464 det the,expense
R2187 T7464 T7462 pobj expense,at
R2188 T7465 T7464 prep of,expense
R2189 T7466 T7465 pcomp increasing,of
R2190 T7467 T7468 amod false,positive
R2191 T7468 T7469 amod positive,QTL
R2192 T7469 T7466 dobj QTL,increasing
R2193 T7470 T7424 punct .,suggested
R2194 T7472 T7473 advcl Being,examined
R2195 T7474 T7472 acomp aware,Being
R2196 T7475 T7474 prep of,aware
R2197 T7476 T7475 pobj this,of
R2198 T7477 T7473 punct ", ",examined
R2199 T7478 T7473 nsubj we,examined
R2200 T7479 T7480 det these,regions
R2201 T7480 T7473 dobj regions,examined
R2202 T7481 T7480 amod genomic,regions
R2203 T7482 T7483 aux to,search
R2204 T7483 T7473 advcl search,examined
R2205 T7484 T7485 mark whether,linked
R2206 T7485 T7483 ccomp linked,search
R2207 T7486 T7485 nsubjpass they,linked
R2208 T7487 T7486 punct ", ",they
R2209 T7488 T7486 cc or,they
R2210 T7489 T7490 poss their,regions
R2211 T7490 T7486 conj regions,they
R2212 T7491 T7490 amod syntenic,regions
R2213 T7492 T7490 amod genomic,regions
R2214 T7493 T7490 prep on,regions
R2215 T7494 T7495 det the,genome
R2216 T7495 T7493 pobj genome,on
R2217 T7496 T7495 amod human,genome
R2218 T7497 T7485 punct ", ",linked
R2219 T7498 T7485 aux have,linked
R2220 T7499 T7485 auxpass been,linked
R2221 T7500 T7485 advmod previously,linked
R2222 T7501 T7485 prep to,linked
R2223 T7502 T7501 pobj arthritis,to
R2224 T7503 T7473 punct .,examined
R2225 T7505 T7506 nummod Four,QTL
R2226 T7506 T7510 nsubj QTL,overlapped
R2227 T7507 T7508 amod small,effect
R2228 T7508 T7506 compound effect,QTL
R2229 T7509 T7508 punct -,effect
R2230 T7511 T7510 prep with,overlapped
R2231 T7512 T7513 compound arthritis,QTL
R2232 T7513 T7511 pobj QTL,with
R2233 T7514 T7510 prep on,overlapped
R2234 T7515 T7516 det the,genome
R2235 T7516 T7514 pobj genome,on
R2236 T7517 T7516 compound mouse,genome
R2237 T7518 T7516 acl identified,genome
R2238 T7519 T7518 advmod previously,identified
R2239 T7520 T7510 punct .,overlapped
R2240 T7522 T7523 nmod Locus,1
R2241 T7523 T7524 nsubj 1,overlap
R2242 T7525 T7523 cc and,1
R2243 T7526 T7523 conj 2,1
R2244 T7527 T7524 prep with,overlap
R2245 T7528 T7527 pobj Cia13,with
R2246 T7529 T7528 cc and,Cia13
R2247 T7530 T7528 conj Cia14,Cia13
R2248 T7531 T7528 punct ", ",Cia13
R2249 T7532 T7533 dep which,control
R2250 T7533 T7528 relcl control,Cia13
R2251 T7534 T7533 dobj severity,control
R2252 T7535 T7534 prep of,severity
R2253 T7536 T7535 pobj CIA,of
R2254 T7537 T7533 prep in,control
R2255 T7538 T7539 punct (,DBA
R2256 T7539 T7540 nmod DBA,progeny
R2257 T7540 T7537 pobj progeny,in
R2258 T7541 T7539 punct /,DBA
R2259 T7542 T7539 nummod 1,DBA
R2260 T7543 T7539 punct ×,DBA
R2261 T7544 T7545 compound BALB,C
R2262 T7545 T7539 appos C,DBA
R2263 T7546 T7545 punct /,C
R2264 T7547 T7539 punct ),DBA
R2265 T7548 T7540 compound F2,progeny
R2266 T7549 T7550 punct [,27
R2267 T7550 T7524 parataxis 27,overlap
R2268 T7551 T7550 punct ],27
R2269 T7552 T7524 punct .,overlap
R2270 T7554 T7555 nsubj Locus,overlaps
R2271 T7556 T7554 nummod 5,Locus
R2272 T7557 T7554 acl located,Locus
R2273 T7558 T7557 prep on,located
R2274 T7559 T7558 pobj chromosome,on
R2275 T7560 T7559 nummod 10,chromosome
R2276 T7561 T7555 prep with,overlaps
R2277 T7562 T7561 pobj Cia8,with
R2278 T7563 T7562 punct ", ",Cia8
R2279 T7564 T7565 dep which,identified
R2280 T7565 T7562 relcl identified,Cia8
R2281 T7566 T7565 auxpass was,identified
R2282 T7567 T7565 prep in,identified
R2283 T7568 T7569 punct (,DBA
R2284 T7569 T7570 nmod DBA,progeny
R2285 T7570 T7567 pobj progeny,in
R2286 T7571 T7569 punct /,DBA
R2287 T7572 T7569 nummod 1,DBA
R2288 T7573 T7569 punct ×,DBA
R2289 T7574 T7569 appos B10.Q,DBA
R2290 T7575 T7570 punct ),progeny
R2291 T7576 T7570 compound F2,progeny
R2292 T7577 T7578 punct [,28
R2293 T7578 T7555 parataxis 28,overlaps
R2294 T7579 T7578 punct ],28
R2295 T7580 T7555 punct .,overlaps
R2296 T7582 T7583 nsubj Locus,overlaps
R2297 T7584 T7582 nummod 6,Locus
R2298 T7585 T7583 prep with,overlaps
R2299 T7586 T7585 pobj Pgia7,with
R2300 T7587 T7586 punct ", ",Pgia7
R2301 T7588 T7589 dep which,controls
R2302 T7589 T7586 relcl controls,Pgia7
R2303 T7590 T7589 dobj susceptibility,controls
R2304 T7591 T7590 prep to,susceptibility
R2305 T7592 T7593 npadvmod proteoglycan,induced
R2306 T7593 T7595 amod induced,arthritis
R2307 T7594 T7593 punct -,induced
R2308 T7595 T7591 pobj arthritis,to
R2309 T7596 T7595 punct (,arthritis
R2310 T7597 T7595 appos PGIA,arthritis
R2311 T7598 T7589 punct ),controls
R2312 T7599 T7589 cc and,controls
R2313 T7600 T7601 auxpass was,identified
R2314 T7601 T7589 conj identified,controls
R2315 T7602 T7601 prep in,identified
R2316 T7603 T7604 punct (,C
R2317 T7604 T7607 nmod C,progeny
R2318 T7605 T7604 nmod BALB,C
R2319 T7606 T7604 punct /,C
R2320 T7607 T7602 pobj progeny,in
R2321 T7608 T7604 punct ×,C
R2322 T7609 T7604 appos DBA,C
R2323 T7610 T7609 punct /,DBA
R2324 T7611 T7609 nummod 2,DBA
R2325 T7612 T7604 punct ),C
R2326 T7613 T7607 compound F2,progeny
R2327 T7614 T7615 punct [,29
R2328 T7615 T7583 parataxis 29,overlaps
R2329 T7616 T7615 punct ],29
R2330 T7617 T7583 punct .,overlaps
R2331 T7619 T7620 det The,regions
R2332 T7620 T7623 nsubjpass regions,reported
R2333 T7621 T7620 amod syntenic,regions
R2334 T7622 T7620 amod genomic,regions
R2335 T7624 T7620 prep of,regions
R2336 T7625 T7626 nummod five,QTL
R2337 T7626 T7624 pobj QTL,of
R2338 T7627 T7628 amod small,effect
R2339 T7628 T7626 compound effect,QTL
R2340 T7629 T7628 punct -,effect
R2341 T7630 T7626 prep on,QTL
R2342 T7631 T7632 det the,genome
R2343 T7632 T7630 pobj genome,on
R2344 T7633 T7632 amod human,genome
R2345 T7634 T7623 aux have,reported
R2346 T7635 T7623 auxpass been,reported
R2347 T7636 T7637 aux to,linked
R2348 T7637 T7623 xcomp linked,reported
R2349 T7638 T7637 auxpass be,linked
R2350 T7639 T7637 prep to,linked
R2351 T7640 T7639 pobj RA,to
R2352 T7641 T7623 punct .,reported
R2353 T7643 T7644 nsubj These,are
R2354 T7645 T7646 amod genomic,regions
R2355 T7646 T7644 attr regions,are
R2356 T7647 T7646 appos 22q11,regions
R2357 T7648 T7647 cc and,22q11
R2358 T7649 T7650 compound 12p13,q24
R2359 T7650 T7647 conj q24,22q11
R2360 T7651 T7650 punct -,q24
R2361 T7652 T7646 prep on,regions
R2362 T7653 T7654 nmod chromosome,22
R2363 T7654 T7652 pobj 22,on
R2364 T7655 T7654 cc and,22
R2365 T7656 T7654 conj 12,22
R2366 T7657 T7658 punct (,counterparts
R2367 T7658 T7646 parataxis counterparts,regions
R2368 T7659 T7658 det the,counterparts
R2369 T7660 T7658 prep of,counterparts
R2370 T7661 T7660 pobj locus,of
R2371 T7662 T7661 nummod 2,locus
R2372 T7663 T7658 punct ),counterparts
R2373 T7664 T7646 punct ", ",regions
R2374 T7665 T7666 compound 12p13,pter
R2375 T7666 T7646 conj pter,regions
R2376 T7667 T7666 punct -,pter
R2377 T7668 T7666 prep on,pter
R2378 T7669 T7668 pobj chromosome,on
R2379 T7670 T7669 nummod 12,chromosome
R2380 T7671 T7672 punct (,counterpart
R2381 T7672 T7666 parataxis counterpart,pter
R2382 T7673 T7672 det the,counterpart
R2383 T7674 T7672 prep of,counterpart
R2384 T7675 T7674 pobj locus,of
R2385 T7676 T7675 nummod 3,locus
R2386 T7677 T7672 punct ),counterpart
R2387 T7678 T7666 punct ", ",pter
R2388 T7679 T7680 compound 21q22,qter
R2389 T7680 T7666 conj qter,pter
R2390 T7681 T7680 punct -,qter
R2391 T7682 T7680 cc and,qter
R2392 T7683 T7680 conj 10q22,qter
R2393 T7684 T7683 punct -,10q22
R2394 T7685 T7683 nummod 23,10q22
R2395 T7686 T7680 prep on,qter
R2396 T7687 T7688 nmod chromosome,21
R2397 T7688 T7686 pobj 21,on
R2398 T7689 T7688 cc and,21
R2399 T7690 T7688 conj 10,21
R2400 T7691 T7692 punct (,counterparts
R2401 T7692 T7680 parataxis counterparts,qter
R2402 T7693 T7692 det the,counterparts
R2403 T7694 T7692 prep of,counterparts
R2404 T7695 T7694 pobj locus,of
R2405 T7696 T7695 nummod 5,locus
R2406 T7697 T7692 punct ),counterparts
R2407 T7698 T7680 punct ", ",qter
R2408 T7699 T7680 conj 17q21,qter
R2409 T7700 T7699 punct -,17q21
R2410 T7701 T7699 nummod 25,17q21
R2411 T7702 T7699 prep on,17q21
R2412 T7703 T7702 pobj chromosome,on
R2413 T7704 T7703 nummod 17,chromosome
R2414 T7705 T7706 punct (,counterpart
R2415 T7706 T7699 parataxis counterpart,17q21
R2416 T7707 T7706 det the,counterpart
R2417 T7708 T7706 prep of,counterpart
R2418 T7709 T7708 pobj locus,of
R2419 T7710 T7709 nummod 6,locus
R2420 T7711 T7706 punct ),counterpart
R2421 T7712 T7699 cc and,17q21
R2422 T7713 T7714 compound 3q29,qter
R2423 T7714 T7699 conj qter,17q21
R2424 T7715 T7714 punct -,qter
R2425 T7716 T7714 prep on,qter
R2426 T7717 T7716 pobj chromosome,on
R2427 T7718 T7717 nummod 3,chromosome
R2428 T7719 T7720 punct (,counterpart
R2429 T7720 T7714 parataxis counterpart,qter
R2430 T7721 T7720 det the,counterpart
R2431 T7722 T7720 prep of,counterpart
R2432 T7723 T7722 pobj locus,of
R2433 T7724 T7723 nummod 7,locus
R2434 T7725 T7720 punct ),counterpart
R2435 T7726 T7727 punct [,4
R2436 T7727 T7644 parataxis 4,are
R2437 T7728 T7727 nummod 2,4
R2438 T7729 T7727 punct ",",4
R2439 T7730 T7727 punct ],4
R2440 T7731 T7644 punct .,are