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PMC:1858683 / 22277-23616 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T10362 0-13 RB denotes Interestingly
T10364 13-15 , denotes ,
T10365 15-22 RB denotes however
T10366 22-24 , denotes ,
T10367 24-28 RB denotes even
T10368 29-31 IN denotes in
T10369 32-36 JJ denotes wild
T10371 36-37 HYPH denotes -
T10370 37-41 NN denotes type
T10372 42-46 NNS denotes mice
T10373 47-50 DT denotes the
T10375 51-54 NN denotes BAT
T10377 54-55 HYPH denotes -
T10376 55-58 NN denotes gal
T10374 59-67 NN denotes reporter
T10363 68-74 VBD denotes showed
T10378 75-77 DT denotes no
T10379 78-88 NN denotes expression
T10380 89-91 IN denotes in
T10381 92-95 DT denotes the
T10383 96-106 VBG denotes developing
T10384 107-118 JJ denotes metanephric
T10382 119-129 NN denotes mesenchyme
T10385 129-131 , denotes ,
T10386 131-133 CC denotes or
T10387 134-145 JJ denotes metanephric
T10388 146-156 NN denotes mesenchyme
T10390 156-157 HYPH denotes -
T10389 157-164 VBN denotes derived
T10391 165-175 NNS denotes structures
T10392 175-177 , denotes ,
T10393 177-181 JJ denotes such
T10394 182-184 IN denotes as
T10395 185-190 JJ denotes renal
T10396 191-199 NNS denotes vesicles
T10397 199-201 , denotes ,
T10398 201-202 NN denotes S
T10400 202-203 HYPH denotes -
T10399 203-209 VBN denotes shaped
T10401 210-216 NNS denotes bodies
T10402 216-218 , denotes ,
T10403 218-225 NNS denotes tubules
T10404 225-227 , denotes ,
T10405 227-230 CC denotes and
T10406 231-240 NNS denotes glomeruli
T10407 240-241 . denotes .
T10408 241-383 sentence denotes This has been reported previously, and was interpreted to indicate the absence of canonical Wnt signaling in the metanephric mesenchyme [21].
T10409 242-246 DT denotes This
T10411 247-250 VBZ denotes has
T10412 251-255 VBN denotes been
T10410 256-264 VBN denotes reported
T10413 265-275 RB denotes previously
T10414 275-277 , denotes ,
T10415 277-280 CC denotes and
T10416 281-284 VBD denotes was
T10417 285-296 VBN denotes interpreted
T10418 297-299 TO denotes to
T10419 300-308 VB denotes indicate
T10420 309-312 DT denotes the
T10421 313-320 NN denotes absence
T10422 321-323 IN denotes of
T10423 324-333 JJ denotes canonical
T10425 334-337 NN denotes Wnt
T10424 338-347 NN denotes signaling
T10426 348-350 IN denotes in
T10427 351-354 DT denotes the
T10429 355-366 JJ denotes metanephric
T10428 367-377 NN denotes mesenchyme
T10430 378-379 -LRB- denotes [
T10431 379-381 CD denotes 21
T10432 381-382 -RRB- denotes ]
T10433 382-383 . denotes .
T10434 383-501 sentence denotes Results from other studies, however, argue for the presence of canonical Wnt signaling in the metanephric mesenchyme.
T10435 384-391 NNS denotes Results
T10437 392-396 IN denotes from
T10438 397-402 JJ denotes other
T10439 403-410 NNS denotes studies
T10440 410-412 , denotes ,
T10441 412-419 RB denotes however
T10442 419-421 , denotes ,
T10436 421-426 VBP denotes argue
T10443 427-430 IN denotes for
T10444 431-434 DT denotes the
T10445 435-443 NN denotes presence
T10446 444-446 IN denotes of
T10447 447-456 JJ denotes canonical
T10449 457-460 NN denotes Wnt
T10448 461-470 NN denotes signaling
T10450 471-473 IN denotes in
T10451 474-477 DT denotes the
T10453 478-489 JJ denotes metanephric
T10452 490-500 NN denotes mesenchyme
T10454 500-501 . denotes .
T10455 501-680 sentence denotes For example, ureteric bud expression of Wnt1, thought to act through canonical Wnt signaling, can rescue Wnt9b mutants and induce nephrogenesis of the metanephric mesenchyme [2].
T10456 502-505 IN denotes For
T10458 506-513 NN denotes example
T10459 513-515 , denotes ,
T10460 515-523 JJ denotes ureteric
T10461 524-527 NN denotes bud
T10462 528-538 NN denotes expression
T10463 539-541 IN denotes of
T10464 542-546 NN denotes Wnt1
T10465 546-548 , denotes ,
T10466 548-555 VBN denotes thought
T10467 556-558 TO denotes to
T10468 559-562 VB denotes act
T10469 563-570 IN denotes through
T10470 571-580 JJ denotes canonical
T10472 581-584 NN denotes Wnt
T10471 585-594 NN denotes signaling
T10473 594-596 , denotes ,
T10474 596-599 MD denotes can
T10457 600-606 VB denotes rescue
T10475 607-612 NN denotes Wnt9b
T10476 613-620 NNS denotes mutants
T10477 621-624 CC denotes and
T10478 625-631 VB denotes induce
T10479 632-645 NN denotes nephrogenesis
T10480 646-648 IN denotes of
T10481 649-652 DT denotes the
T10483 653-664 JJ denotes metanephric
T10482 665-675 NN denotes mesenchyme
T10484 676-677 -LRB- denotes [
T10485 677-678 CD denotes 2
T10486 678-679 -RRB- denotes ]
T10487 679-680 . denotes .
T10488 680-804 sentence denotes This suggests that the BAT-gal transgene might not accurately report canonical Wnt signaling in the metanephric mesenchyme.
T10489 681-685 DT denotes This
T10490 686-694 VBZ denotes suggests
T10491 695-699 IN denotes that
T10493 700-703 DT denotes the
T10495 704-707 NN denotes BAT
T10497 707-708 HYPH denotes -
T10496 708-711 NN denotes gal
T10494 712-721 NN denotes transgene
T10498 722-727 MD denotes might
T10499 728-731 RB denotes not
T10500 732-742 RB denotes accurately
T10492 743-749 VB denotes report
T10501 750-759 JJ denotes canonical
T10503 760-763 NN denotes Wnt
T10502 764-773 NN denotes signaling
T10504 774-776 IN denotes in
T10505 777-780 DT denotes the
T10507 781-792 JJ denotes metanephric
T10506 793-803 NN denotes mesenchyme
T10508 803-804 . denotes .
T10509 804-1048 sentence denotes To address this question, we incubated E11.5 metanephric mesenchyme in lithium chloride (LiCl), which activates canonical Wnt signaling through inhibition of GSK3, and also functions as an inducer of nephrogenesis in kidney organ culture [22].
T10510 805-807 TO denotes To
T10511 808-815 VB denotes address
T10513 816-820 DT denotes this
T10514 821-829 NN denotes question
T10515 829-831 , denotes ,
T10516 831-833 PRP denotes we
T10512 834-843 VBD denotes incubated
T10517 844-849 NN denotes E11.5
T10519 850-861 JJ denotes metanephric
T10518 862-872 NN denotes mesenchyme
T10520 873-875 IN denotes in
T10521 876-883 NN denotes lithium
T10522 884-892 NN denotes chloride
T10523 893-894 -LRB- denotes (
T10524 894-898 NN denotes LiCl
T10525 898-899 -RRB- denotes )
T10526 899-901 , denotes ,
T10527 901-906 WDT denotes which
T10528 907-916 VBZ denotes activates
T10529 917-926 JJ denotes canonical
T10531 927-930 NN denotes Wnt
T10530 931-940 NN denotes signaling
T10532 941-948 IN denotes through
T10533 949-959 NN denotes inhibition
T10534 960-962 IN denotes of
T10535 963-967 NN denotes GSK3
T10536 967-969 , denotes ,
T10537 969-972 CC denotes and
T10538 973-977 RB denotes also
T10539 978-987 VBZ denotes functions
T10540 988-990 IN denotes as
T10541 991-993 DT denotes an
T10542 994-1001 NN denotes inducer
T10543 1002-1004 IN denotes of
T10544 1005-1018 NN denotes nephrogenesis
T10545 1019-1021 IN denotes in
T10546 1022-1028 NN denotes kidney
T10547 1029-1034 NN denotes organ
T10548 1035-1042 NN denotes culture
T10549 1043-1044 -LRB- denotes [
T10550 1044-1046 CD denotes 22
T10551 1046-1047 -RRB- denotes ]
T10552 1047-1048 . denotes .
T10553 1048-1339 sentence denotes We observed that LiCl-treated metanephric mesenchyme did undergo nephrogenesis, as expected, but failed to show BAT-gal expression (data not shown), suggesting that this transgene is not an accurate reporter of canonical Wnt signaling in the metanephric mesenchyme of the developing kidney.
T10554 1049-1051 PRP denotes We
T10555 1052-1060 VBD denotes observed
T10556 1061-1065 IN denotes that
T10558 1066-1070 NN denotes LiCl
T10560 1070-1071 HYPH denotes -
T10559 1071-1078 VBN denotes treated
T10562 1079-1090 JJ denotes metanephric
T10561 1091-1101 NN denotes mesenchyme
T10563 1102-1105 VBD denotes did
T10557 1106-1113 VB denotes undergo
T10564 1114-1127 NN denotes nephrogenesis
T10565 1127-1129 , denotes ,
T10566 1129-1131 IN denotes as
T10567 1132-1140 VBN denotes expected
T10568 1140-1142 , denotes ,
T10569 1142-1145 CC denotes but
T10570 1146-1152 VBD denotes failed
T10571 1153-1155 TO denotes to
T10572 1156-1160 VB denotes show
T10573 1161-1164 NN denotes BAT
T10575 1164-1165 HYPH denotes -
T10574 1165-1168 NN denotes gal
T10576 1169-1179 NN denotes expression
T10577 1180-1181 -LRB- denotes (
T10579 1181-1185 NNS denotes data
T10580 1186-1189 RB denotes not
T10578 1190-1195 VBN denotes shown
T10581 1195-1196 -RRB- denotes )
T10582 1196-1198 , denotes ,
T10583 1198-1208 VBG denotes suggesting
T10584 1209-1213 IN denotes that
T10586 1214-1218 DT denotes this
T10587 1219-1228 NN denotes transgene
T10585 1229-1231 VBZ denotes is
T10588 1232-1235 RB denotes not
T10589 1236-1238 DT denotes an
T10591 1239-1247 JJ denotes accurate
T10590 1248-1256 NN denotes reporter
T10592 1257-1259 IN denotes of
T10593 1260-1269 JJ denotes canonical
T10595 1270-1273 NN denotes Wnt
T10594 1274-1283 NN denotes signaling
T10596 1284-1286 IN denotes in
T10597 1287-1290 DT denotes the
T10599 1291-1302 JJ denotes metanephric
T10598 1303-1313 NN denotes mesenchyme
T10600 1314-1316 IN denotes of
T10601 1317-1320 DT denotes the
T10603 1321-1331 VBG denotes developing
T10602 1332-1338 NN denotes kidney
T10604 1338-1339 . denotes .
R2772 T10362 T10363 advmod Interestingly,showed
R2774 T10364 T10363 punct ", ",showed
R2776 T10365 T10363 advmod however,showed
R2777 T10366 T10363 punct ", ",showed
R2779 T10367 T10368 advmod even,in
R2780 T10368 T10363 prep in,showed
R2781 T10369 T10370 amod wild,type
R2783 T10370 T10372 compound type,mice
R2784 T10371 T10370 punct -,type
R2785 T10372 T10368 pobj mice,in
R2786 T10373 T10374 det the,reporter
R2787 T10374 T10363 nsubj reporter,showed
R2789 T10375 T10376 compound BAT,gal
R2790 T10376 T10374 compound gal,reporter
R2791 T10377 T10376 punct -,gal
R2792 T10378 T10379 det no,expression
R2794 T10379 T10363 dobj expression,showed
R2795 T10380 T10379 prep in,expression
R2797 T10381 T10382 det the,mesenchyme
R2798 T10382 T10380 pobj mesenchyme,in
R2799 T10383 T10382 amod developing,mesenchyme
R2801 T10384 T10382 amod metanephric,mesenchyme
R2802 T10385 T10382 punct ", ",mesenchyme
R2803 T10386 T10382 cc or,mesenchyme
R2805 T10387 T10388 amod metanephric,mesenchyme
R2806 T10388 T10389 npadvmod mesenchyme,derived
R2807 T10389 T10391 amod derived,structures
R2809 T10390 T10389 punct -,derived
R2810 T10391 T10382 conj structures,mesenchyme
R2812 T10392 T10391 punct ", ",structures
R2813 T10393 T10394 amod such,as
R2814 T10394 T10391 prep as,structures
R2815 T10395 T10396 amod renal,vesicles
R2817 T10396 T10394 pobj vesicles,as
R2818 T10397 T10396 punct ", ",vesicles
R2820 T10398 T10399 npadvmod S,shaped
R2821 T10399 T10401 amod shaped,bodies
R2822 T10400 T10399 punct -,shaped
R2823 T10401 T10396 conj bodies,vesicles
R2824 T10402 T10401 punct ", ",bodies
R2825 T10460 T10461 amod ureteric,bud
R2826 T10403 T10401 conj tubules,bodies
R2827 T10404 T10403 punct ", ",tubules
R2828 T10405 T10403 cc and,tubules
R2829 T10406 T10403 conj glomeruli,tubules
R2830 T10461 T10462 compound bud,expression
R2831 T10407 T10363 punct .,showed
R2832 T10409 T10410 nsubjpass This,reported
R2833 T10462 T10457 nsubj expression,rescue
R2834 T10411 T10410 aux has,reported
R2835 T10412 T10410 auxpass been,reported
R2836 T10463 T10462 prep of,expression
R2837 T10413 T10410 advmod previously,reported
R2838 T10414 T10410 punct ", ",reported
R2839 T10415 T10410 cc and,reported
R2840 T10416 T10417 auxpass was,interpreted
R2841 T10417 T10410 conj interpreted,reported
R2842 T10464 T10463 pobj Wnt1,of
R2843 T10418 T10419 aux to,indicate
R2844 T10419 T10417 xcomp indicate,interpreted
R2845 T10420 T10421 det the,absence
R2846 T10465 T10462 punct ", ",expression
R2847 T10421 T10419 dobj absence,indicate
R2848 T10422 T10421 prep of,absence
R2849 T10423 T10424 amod canonical,signaling
R2850 T10424 T10422 pobj signaling,of
R2851 T10466 T10462 acl thought,expression
R2852 T10425 T10424 compound Wnt,signaling
R2853 T10426 T10421 prep in,absence
R2854 T10467 T10468 aux to,act
R2855 T10427 T10428 det the,mesenchyme
R2856 T10428 T10426 pobj mesenchyme,in
R2857 T10429 T10428 amod metanephric,mesenchyme
R2858 T10430 T10431 punct [,21
R2859 T10468 T10466 xcomp act,thought
R2860 T10431 T10419 parataxis 21,indicate
R2861 T10432 T10431 punct ],21
R2862 T10469 T10468 prep through,act
R2863 T10433 T10410 punct .,reported
R2864 T10435 T10436 nsubj Results,argue
R2865 T10470 T10471 amod canonical,signaling
R2866 T10437 T10435 prep from,Results
R2867 T10471 T10469 pobj signaling,through
R2868 T10438 T10439 amod other,studies
R2869 T10439 T10437 pobj studies,from
R2870 T10440 T10436 punct ", ",argue
R2871 T10441 T10436 advmod however,argue
R2872 T10472 T10471 compound Wnt,signaling
R2873 T10442 T10436 punct ", ",argue
R2874 T10443 T10436 prep for,argue
R2875 T10444 T10445 det the,presence
R2876 T10473 T10457 punct ", ",rescue
R2877 T10445 T10443 pobj presence,for
R2878 T10446 T10445 prep of,presence
R2879 T10447 T10448 amod canonical,signaling
R2880 T10474 T10457 aux can,rescue
R2881 T10448 T10446 pobj signaling,of
R2882 T10449 T10448 compound Wnt,signaling
R2883 T10450 T10445 prep in,presence
R2884 T10451 T10452 det the,mesenchyme
R2885 T10475 T10476 compound Wnt9b,mutants
R2886 T10452 T10450 pobj mesenchyme,in
R2887 T10453 T10452 amod metanephric,mesenchyme
R2888 T10454 T10436 punct .,argue
R2889 T10476 T10457 dobj mutants,rescue
R2890 T10456 T10457 prep For,rescue
R2891 T10458 T10456 pobj example,For
R2892 T10459 T10457 punct ", ",rescue
R2893 T10477 T10457 cc and,rescue
R2894 T10478 T10457 conj induce,rescue
R2895 T10479 T10478 dobj nephrogenesis,induce
R2896 T10566 T10567 mark as,expected
R2897 T10480 T10479 prep of,nephrogenesis
R2898 T10567 T10557 advcl expected,undergo
R2899 T10568 T10557 punct ", ",undergo
R2900 T10481 T10482 det the,mesenchyme
R2901 T10569 T10557 cc but,undergo
R2902 T10570 T10557 conj failed,undergo
R2903 T10482 T10480 pobj mesenchyme,of
R2904 T10571 T10572 aux to,show
R2905 T10572 T10570 xcomp show,failed
R2906 T10573 T10574 compound BAT,gal
R2907 T10483 T10482 amod metanephric,mesenchyme
R2908 T10574 T10576 compound gal,expression
R2909 T10575 T10574 punct -,gal
R2910 T10576 T10572 dobj expression,show
R2911 T10484 T10485 punct [,2
R2912 T10485 T10478 parataxis 2,induce
R2913 T10577 T10578 punct (,shown
R2914 T10578 T10572 parataxis shown,show
R2915 T10486 T10485 punct ],2
R2916 T10579 T10578 nsubj data,shown
R2917 T10580 T10578 neg not,shown
R2918 T10581 T10578 punct ),shown
R2919 T10487 T10457 punct .,rescue
R2920 T10582 T10570 punct ", ",failed
R2921 T10583 T10570 advcl suggesting,failed
R2922 T10584 T10585 mark that,is
R2923 T10489 T10490 nsubj This,suggests
R2924 T10585 T10583 ccomp is,suggesting
R2925 T10586 T10587 det this,transgene
R2926 T10587 T10585 nsubj transgene,is
R2927 T10491 T10492 mark that,report
R2928 T10588 T10585 neg not,is
R2929 T10589 T10590 det an,reporter
R2930 T10590 T10585 attr reporter,is
R2931 T10591 T10590 amod accurate,reporter
R2932 T10492 T10490 ccomp report,suggests
R2933 T10592 T10590 prep of,reporter
R2934 T10593 T10594 amod canonical,signaling
R2935 T10594 T10592 pobj signaling,of
R2936 T10493 T10494 det the,transgene
R2937 T10595 T10594 compound Wnt,signaling
R2938 T10596 T10590 prep in,reporter
R2939 T10597 T10598 det the,mesenchyme
R2940 T10494 T10492 nsubj transgene,report
R2941 T10598 T10596 pobj mesenchyme,in
R2942 T10599 T10598 amod metanephric,mesenchyme
R2943 T10600 T10598 prep of,mesenchyme
R2944 T10601 T10602 det the,kidney
R2945 T10602 T10600 pobj kidney,of
R2946 T10603 T10602 amod developing,kidney
R2947 T10495 T10496 compound BAT,gal
R2948 T10604 T10555 punct .,observed
R2949 T10496 T10494 compound gal,transgene
R2950 T10497 T10496 punct -,gal
R2951 T10498 T10492 aux might,report
R2952 T10499 T10492 neg not,report
R2953 T10500 T10492 advmod accurately,report
R2954 T10501 T10502 amod canonical,signaling
R2955 T10502 T10492 dobj signaling,report
R2956 T10503 T10502 compound Wnt,signaling
R2957 T10504 T10492 prep in,report
R2958 T10505 T10506 det the,mesenchyme
R2959 T10506 T10504 pobj mesenchyme,in
R2960 T10507 T10506 amod metanephric,mesenchyme
R2961 T10508 T10490 punct .,suggests
R2962 T10510 T10511 aux To,address
R2963 T10511 T10512 advcl address,incubated
R2964 T10513 T10514 det this,question
R2965 T10514 T10511 dobj question,address
R2966 T10515 T10512 punct ", ",incubated
R2967 T10516 T10512 nsubj we,incubated
R2968 T10517 T10518 nmod E11.5,mesenchyme
R2969 T10518 T10512 dobj mesenchyme,incubated
R2970 T10519 T10518 amod metanephric,mesenchyme
R2971 T10520 T10512 prep in,incubated
R2972 T10521 T10522 compound lithium,chloride
R2973 T10522 T10520 pobj chloride,in
R2974 T10523 T10522 punct (,chloride
R2975 T10524 T10522 appos LiCl,chloride
R2976 T10525 T10522 punct ),chloride
R2977 T10526 T10522 punct ", ",chloride
R2978 T10527 T10528 dep which,activates
R2979 T10528 T10522 relcl activates,chloride
R2980 T10529 T10530 amod canonical,signaling
R2981 T10530 T10528 dobj signaling,activates
R2982 T10531 T10530 compound Wnt,signaling
R2983 T10532 T10528 prep through,activates
R2984 T10533 T10532 pobj inhibition,through
R2985 T10534 T10533 prep of,inhibition
R2986 T10535 T10534 pobj GSK3,of
R2987 T10536 T10528 punct ", ",activates
R2988 T10537 T10528 cc and,activates
R2989 T10538 T10539 advmod also,functions
R2990 T10539 T10528 conj functions,activates
R2991 T10540 T10539 prep as,functions
R2992 T10541 T10542 det an,inducer
R2993 T10542 T10540 pobj inducer,as
R2994 T10543 T10542 prep of,inducer
R2995 T10544 T10543 pobj nephrogenesis,of
R2996 T10545 T10542 prep in,inducer
R2997 T10546 T10547 compound kidney,organ
R2998 T10547 T10548 compound organ,culture
R2999 T10548 T10545 pobj culture,in
R3000 T10549 T10550 punct [,22
R3001 T10550 T10539 parataxis 22,functions
R3002 T10551 T10550 punct ],22
R3003 T10552 T10512 punct .,incubated
R3004 T10554 T10555 nsubj We,observed
R3005 T10556 T10557 mark that,undergo
R3006 T10557 T10555 ccomp undergo,observed
R3007 T10558 T10559 npadvmod LiCl,treated
R3008 T10559 T10561 amod treated,mesenchyme
R3009 T10560 T10559 punct -,treated
R3010 T10561 T10557 nsubj mesenchyme,undergo
R3011 T10562 T10561 amod metanephric,mesenchyme
R3012 T10563 T10557 aux did,undergo
R3013 T10564 T10557 dobj nephrogenesis,undergo
R3014 T10565 T10557 punct ", ",undergo