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PMC:1635039 / 9470-12503 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T5938 0-8 JJ denotes Abnormal
T5939 9-19 NN denotes patterning
T5940 20-22 IN denotes of
T5941 23-26 DT denotes the
T5943 27-37 JJ denotes pharyngeal
T5944 38-42 NN denotes arch
T5942 43-51 NNS denotes arteries
T5945 52-55 CC denotes and
T5946 56-62 JJ denotes aortic
T5947 63-66 NN denotes sac
T5948 67-69 IN denotes in
T5949 70-74 NN denotes Alk5
T5951 74-75 HYPH denotes /
T5950 75-82 NN denotes Wnt1Cre
T5952 83-90 NNS denotes mutants
T5953 90-239 sentence denotes During cardiovascular development, the PAAs undergo a complex set of sequential asymmetric remodeling steps resulting in the left-sided aortic arch.
T5954 91-97 IN denotes During
T5956 98-112 JJ denotes cardiovascular
T5957 113-124 NN denotes development
T5958 124-126 , denotes ,
T5959 126-129 DT denotes the
T5960 130-134 NNS denotes PAAs
T5955 135-142 VBP denotes undergo
T5961 143-144 DT denotes a
T5963 145-152 JJ denotes complex
T5962 153-156 NN denotes set
T5964 157-159 IN denotes of
T5965 160-170 JJ denotes sequential
T5967 171-181 JJ denotes asymmetric
T5968 182-192 NN denotes remodeling
T5966 193-198 NNS denotes steps
T5969 199-208 VBG denotes resulting
T5970 209-211 IN denotes in
T5971 212-215 DT denotes the
T5973 216-220 JJ denotes left
T5975 220-221 HYPH denotes -
T5974 221-226 VBN denotes sided
T5976 227-233 JJ denotes aortic
T5972 234-238 NN denotes arch
T5977 238-239 . denotes .
T5978 239-403 sentence denotes To determine, whether ALK5-mediated signaling was involved in remodeling of PAAs, we performed intracardiac India ink injections at different developmental stages.
T5979 240-242 TO denotes To
T5980 243-252 VB denotes determine
T5982 252-254 , denotes ,
T5983 254-261 IN denotes whether
T5985 262-266 NN denotes ALK5
T5987 266-267 HYPH denotes -
T5986 267-275 VBN denotes mediated
T5988 276-285 NN denotes signaling
T5989 286-289 VBD denotes was
T5984 290-298 VBN denotes involved
T5990 299-301 IN denotes in
T5991 302-312 NN denotes remodeling
T5992 313-315 IN denotes of
T5993 316-320 NNS denotes PAAs
T5994 320-322 , denotes ,
T5995 322-324 PRP denotes we
T5981 325-334 VBD denotes performed
T5996 335-347 JJ denotes intracardiac
T5998 348-353 NNP denotes India
T5999 354-357 NN denotes ink
T5997 358-368 NNS denotes injections
T6000 369-371 IN denotes at
T6001 372-381 JJ denotes different
T6003 382-395 JJ denotes developmental
T6002 396-402 NNS denotes stages
T6004 402-403 . denotes .
T6005 403-560 sentence denotes While at E10, Alk5/Wnt1-Cre mutants did not show obvious differences in the PAAs, abnormal remodeling became obvious in mutants a day later at E11 (Fig. 2).
T6006 404-409 IN denotes While
T6008 410-412 IN denotes at
T6009 413-416 NN denotes E10
T6010 416-418 , denotes ,
T6011 418-422 NN denotes Alk5
T6013 422-423 HYPH denotes /
T6014 423-427 NN denotes Wnt1
T6015 427-428 HYPH denotes -
T6012 428-431 NN denotes Cre
T6016 432-439 NNS denotes mutants
T6017 440-443 VBD denotes did
T6018 444-447 RB denotes not
T6007 448-452 VB denotes show
T6020 453-460 JJ denotes obvious
T6021 461-472 NNS denotes differences
T6022 473-475 IN denotes in
T6023 476-479 DT denotes the
T6024 480-484 NNS denotes PAAs
T6025 484-486 , denotes ,
T6026 486-494 JJ denotes abnormal
T6027 495-505 NN denotes remodeling
T6019 506-512 VBD denotes became
T6028 513-520 JJ denotes obvious
T6029 521-523 IN denotes in
T6030 524-531 NNS denotes mutants
T6031 532-533 DT denotes a
T6032 534-537 NN denotes day
T6033 538-543 RB denotes later
T6034 544-546 IN denotes at
T6035 547-550 NN denotes E11
T6036 551-552 -LRB- denotes (
T6037 552-556 NN denotes Fig.
T6038 557-558 CD denotes 2
T6039 558-559 -RRB- denotes )
T6040 559-560 . denotes .
T6041 560-622 sentence denotes The controls displayed the well-formed 3rd, 4th and 6th PAAs.
T6042 561-564 DT denotes The
T6043 565-573 NNS denotes controls
T6044 574-583 VBD denotes displayed
T6045 584-587 DT denotes the
T6047 588-592 RB denotes well
T6049 592-593 HYPH denotes -
T6048 593-599 VBN denotes formed
T6050 600-603 JJ denotes 3rd
T6051 603-605 , denotes ,
T6052 605-608 JJ denotes 4th
T6053 609-612 CC denotes and
T6054 613-616 JJ denotes 6th
T6046 617-621 NNS denotes PAAs
T6055 621-622 . denotes .
T6056 622-767 sentence denotes Moreover, the carotid duct (the dorsal aorta between the 3rd and 4th PAAs) was already regressing as demonstrated by the reduced size (Fig. 2A).
T6057 623-631 RB denotes Moreover
T6059 631-633 , denotes ,
T6060 633-636 DT denotes the
T6062 637-644 JJ denotes carotid
T6061 645-649 NN denotes duct
T6063 650-651 -LRB- denotes (
T6064 651-654 DT denotes the
T6066 655-661 JJ denotes dorsal
T6065 662-667 NN denotes aorta
T6067 668-675 IN denotes between
T6068 676-679 DT denotes the
T6070 680-683 JJ denotes 3rd
T6071 684-687 CC denotes and
T6072 688-691 JJ denotes 4th
T6069 692-696 NNS denotes PAAs
T6073 696-697 -RRB- denotes )
T6074 698-701 VBD denotes was
T6075 702-709 RB denotes already
T6058 710-720 VBG denotes regressing
T6076 721-723 IN denotes as
T6077 724-736 VBN denotes demonstrated
T6078 737-739 IN denotes by
T6079 740-743 DT denotes the
T6081 744-751 VBN denotes reduced
T6080 752-756 NN denotes size
T6082 757-758 -LRB- denotes (
T6084 758-762 NN denotes Fig.
T6083 763-765 NN denotes 2A
T6085 765-766 -RRB- denotes )
T6086 766-767 . denotes .
T6087 767-918 sentence denotes In Alk5/Wnt1-Cre mutants, the 3rd and 4th pairs of PAAs were bilaterally hypoplastic, whereas the 6th pair of PAAs was notably hyperplastic (Fig. 2B).
T6088 768-770 IN denotes In
T6090 771-775 NN denotes Alk5
T6092 775-776 HYPH denotes /
T6093 776-780 NN denotes Wnt1
T6094 780-781 HYPH denotes -
T6091 781-784 NN denotes Cre
T6095 785-792 NNS denotes mutants
T6096 792-794 , denotes ,
T6097 794-797 DT denotes the
T6099 798-801 JJ denotes 3rd
T6100 802-805 CC denotes and
T6101 806-809 JJ denotes 4th
T6098 810-815 NNS denotes pairs
T6102 816-818 IN denotes of
T6103 819-823 NNS denotes PAAs
T6089 824-828 VBD denotes were
T6104 829-840 RB denotes bilaterally
T6105 841-852 JJ denotes hypoplastic
T6106 852-854 , denotes ,
T6107 854-861 IN denotes whereas
T6109 862-865 DT denotes the
T6111 866-869 JJ denotes 6th
T6110 870-874 NN denotes pair
T6112 875-877 IN denotes of
T6113 878-882 NNS denotes PAAs
T6108 883-886 VBD denotes was
T6114 887-894 RB denotes notably
T6115 895-907 JJ denotes hyperplastic
T6116 908-909 -LRB- denotes (
T6118 909-913 NN denotes Fig.
T6117 914-916 NN denotes 2B
T6119 916-917 -RRB- denotes )
T6120 917-918 . denotes .
T6121 918-997 sentence denotes Furthermore, the carotid duct was remarkably large, when compared to controls.
T6122 919-930 RB denotes Furthermore
T6124 930-932 , denotes ,
T6125 932-935 DT denotes the
T6127 936-943 JJ denotes carotid
T6126 944-948 NN denotes duct
T6123 949-952 VBD denotes was
T6128 953-963 RB denotes remarkably
T6129 964-969 JJ denotes large
T6130 969-971 , denotes ,
T6131 971-975 WRB denotes when
T6132 976-984 VBN denotes compared
T6133 985-987 IN denotes to
T6134 988-996 NNS denotes controls
T6135 996-997 . denotes .
T6136 997-1220 sentence denotes While the controls displayed an interruption of the carotid duct at E12 and E13 as expected (Fig. 2C), the mutants demonstrated an uncharacteristic break of the dorsal aorta between the 4th and 6th pairs of PAAs (Fig. 2D).
T6137 998-1003 IN denotes While
T6139 1004-1007 DT denotes the
T6140 1008-1016 NNS denotes controls
T6138 1017-1026 VBD denotes displayed
T6142 1027-1029 DT denotes an
T6143 1030-1042 NN denotes interruption
T6144 1043-1045 IN denotes of
T6145 1046-1049 DT denotes the
T6147 1050-1057 JJ denotes carotid
T6146 1058-1062 NN denotes duct
T6148 1063-1065 IN denotes at
T6149 1066-1069 NN denotes E12
T6150 1070-1073 CC denotes and
T6151 1074-1077 NN denotes E13
T6152 1078-1080 IN denotes as
T6153 1081-1089 VBN denotes expected
T6154 1090-1091 -LRB- denotes (
T6156 1091-1095 NN denotes Fig.
T6155 1096-1098 NN denotes 2C
T6157 1098-1099 -RRB- denotes )
T6158 1099-1101 , denotes ,
T6159 1101-1104 DT denotes the
T6160 1105-1112 NNS denotes mutants
T6141 1113-1125 VBD denotes demonstrated
T6161 1126-1128 DT denotes an
T6163 1129-1145 JJ denotes uncharacteristic
T6162 1146-1151 NN denotes break
T6164 1152-1154 IN denotes of
T6165 1155-1158 DT denotes the
T6167 1159-1165 JJ denotes dorsal
T6166 1166-1171 NN denotes aorta
T6168 1172-1179 IN denotes between
T6169 1180-1183 DT denotes the
T6171 1184-1187 JJ denotes 4th
T6172 1188-1191 CC denotes and
T6173 1192-1195 JJ denotes 6th
T6170 1196-1201 NNS denotes pairs
T6174 1202-1204 IN denotes of
T6175 1205-1209 NNS denotes PAAs
T6176 1210-1211 -LRB- denotes (
T6178 1211-1215 NN denotes Fig.
T6177 1216-1218 NN denotes 2D
T6179 1218-1219 -RRB- denotes )
T6180 1219-1220 . denotes .
T6181 1220-1921 sentence denotes Figure 2 Abnormal patterning of the PAAs in Alk5/Wnt1-Cre mutants. Left lateral view after intracardiac ink injections to visualize the developing PAAs at E11.0 (A,B), E12.0 (C, D) and E13.0 (E, F) in controls (A, C, E) and Alk5/Wnt1-Cre mutants (B, D, F). Arrow in A points to the regressing carotid duct. Asterisk in B depicts the corresponding structure in the mutant with no signs of regression. Asterisk in D illustrates the aberrant regression of the dorsal aorta between the 4th and 6th PAAs. PT, pulmonary trunk; Ao, Aorta; TA, truncus arteriosus. Around E11.5, the aortic sac normally forms a distinctive T-shaped structure, as seen in frontal sections of the control sample in Fig. 3(A,C).
T18219 1231-1239 JJ denotes Abnormal
T18220 1240-1250 NN denotes patterning
T18221 1251-1253 IN denotes of
T18222 1254-1257 DT denotes the
T18223 1258-1262 NNS denotes PAAs
T18224 1263-1265 IN denotes in
T18225 1266-1270 NN denotes Alk5
T18227 1270-1271 HYPH denotes /
T18228 1271-1275 NN denotes Wnt1
T18229 1275-1276 HYPH denotes -
T18226 1276-1279 NN denotes Cre
T18230 1280-1287 NNS denotes mutants
T18231 1287-1288 . denotes .
T18232 1288-1478 sentence denotes Left lateral view after intracardiac ink injections to visualize the developing PAAs at E11.0 (A,B), E12.0 (C, D) and E13.0 (E, F) in controls (A, C, E) and Alk5/Wnt1-Cre mutants (B, D, F).
T18233 1289-1293 JJ denotes Left
T18235 1294-1301 JJ denotes lateral
T18234 1302-1306 NN denotes view
T18236 1307-1312 IN denotes after
T18237 1313-1325 JJ denotes intracardiac
T18239 1326-1329 NN denotes ink
T18238 1330-1340 NNS denotes injections
T18240 1341-1343 TO denotes to
T18241 1344-1353 VB denotes visualize
T18242 1354-1357 DT denotes the
T18244 1358-1368 VBG denotes developing
T18243 1369-1373 NNS denotes PAAs
T18245 1374-1376 IN denotes at
T18246 1377-1382 NN denotes E11.0
T18247 1383-1384 -LRB- denotes (
T18249 1384-1385 NN denotes A
T18250 1385-1386 , denotes ,
T18248 1386-1387 NN denotes B
T18251 1387-1388 -RRB- denotes )
T18252 1388-1390 , denotes ,
T18253 1390-1395 NN denotes E12.0
T18254 1396-1397 -LRB- denotes (
T18256 1397-1398 NN denotes C
T18257 1398-1400 , denotes ,
T18255 1400-1401 NN denotes D
T18258 1401-1402 -RRB- denotes )
T18259 1403-1406 CC denotes and
T18260 1407-1412 NN denotes E13.0
T18261 1413-1414 -LRB- denotes (
T18263 1414-1415 NN denotes E
T18264 1415-1417 , denotes ,
T18262 1417-1418 NN denotes F
T18265 1418-1419 -RRB- denotes )
T18266 1420-1422 IN denotes in
T18267 1423-1431 NNS denotes controls
T18268 1432-1433 -LRB- denotes (
T18270 1433-1434 NN denotes A
T18271 1434-1436 , denotes ,
T18272 1436-1437 NN denotes C
T18273 1437-1439 , denotes ,
T18269 1439-1440 NN denotes E
T18274 1440-1441 -RRB- denotes )
T18275 1442-1445 CC denotes and
T18276 1446-1450 NN denotes Alk5
T18278 1450-1451 HYPH denotes /
T18279 1451-1455 NN denotes Wnt1
T18280 1455-1456 HYPH denotes -
T18277 1456-1459 NN denotes Cre
T18281 1460-1467 NNS denotes mutants
T18282 1468-1469 -LRB- denotes (
T18284 1469-1470 NN denotes B
T18285 1470-1472 , denotes ,
T18286 1472-1473 NN denotes D
T18287 1473-1475 , denotes ,
T18283 1475-1476 NN denotes F
T18288 1476-1477 -RRB- denotes )
T18289 1477-1478 . denotes .
T18290 1478-1528 sentence denotes Arrow in A points to the regressing carotid duct.
T18291 1479-1484 NN denotes Arrow
T18293 1485-1487 IN denotes in
T18294 1488-1489 NN denotes A
T18292 1490-1496 VBZ denotes points
T18295 1497-1499 IN denotes to
T18296 1500-1503 DT denotes the
T18298 1504-1514 VBG denotes regressing
T18299 1515-1522 JJ denotes carotid
T18297 1523-1527 NN denotes duct
T18300 1527-1528 . denotes .
T18301 1528-1621 sentence denotes Asterisk in B depicts the corresponding structure in the mutant with no signs of regression.
T18302 1529-1537 NN denotes Asterisk
T18304 1538-1540 IN denotes in
T18305 1541-1542 NN denotes B
T18303 1543-1550 VBZ denotes depicts
T18306 1551-1554 DT denotes the
T18308 1555-1568 VBG denotes corresponding
T18307 1569-1578 NN denotes structure
T18309 1579-1581 IN denotes in
T18310 1582-1585 DT denotes the
T18311 1586-1592 NN denotes mutant
T18312 1593-1597 IN denotes with
T18313 1598-1600 DT denotes no
T18314 1601-1606 NNS denotes signs
T18315 1607-1609 IN denotes of
T18316 1610-1620 NN denotes regression
T18317 1620-1621 . denotes .
T18318 1621-1721 sentence denotes Asterisk in D illustrates the aberrant regression of the dorsal aorta between the 4th and 6th PAAs.
T18319 1622-1630 NN denotes Asterisk
T18321 1631-1633 IN denotes in
T18322 1634-1635 NN denotes D
T18320 1636-1647 VBZ denotes illustrates
T18323 1648-1651 DT denotes the
T18325 1652-1660 JJ denotes aberrant
T18324 1661-1671 NN denotes regression
T18326 1672-1674 IN denotes of
T18327 1675-1678 DT denotes the
T18329 1679-1685 JJ denotes dorsal
T18328 1686-1691 NN denotes aorta
T18330 1692-1699 IN denotes between
T18331 1700-1703 DT denotes the
T18333 1704-1707 JJ denotes 4th
T18334 1708-1711 CC denotes and
T18335 1712-1715 JJ denotes 6th
T18332 1716-1720 NNS denotes PAAs
T18336 1720-1721 . denotes .
T18337 1721-1777 sentence denotes PT, pulmonary trunk; Ao, Aorta; TA, truncus arteriosus.
T18338 1722-1724 NN denotes PT
T18339 1724-1726 , denotes ,
T18340 1726-1735 JJ denotes pulmonary
T18341 1736-1741 NN denotes trunk
T18342 1741-1742 : denotes ;
T18343 1743-1745 NN denotes Ao
T18344 1745-1747 , denotes ,
T18345 1747-1752 NN denotes Aorta
T18346 1752-1753 : denotes ;
T18347 1754-1756 NN denotes TA
T18348 1756-1758 , denotes ,
T18349 1758-1765 NN denotes truncus
T18350 1766-1776 NN denotes arteriosus
T18351 1776-1777 . denotes .
T6182 1778-1784 IN denotes Around
T6184 1785-1790 NN denotes E11.5
T6185 1790-1792 , denotes ,
T6186 1792-1795 DT denotes the
T6188 1796-1802 JJ denotes aortic
T6187 1803-1806 NN denotes sac
T6189 1807-1815 RB denotes normally
T6183 1816-1821 VBZ denotes forms
T6190 1822-1823 DT denotes a
T6192 1824-1835 JJ denotes distinctive
T6193 1836-1837 NN denotes T
T6195 1837-1838 HYPH denotes -
T6194 1838-1844 VBN denotes shaped
T6191 1845-1854 NN denotes structure
T6196 1854-1856 , denotes ,
T6197 1856-1858 IN denotes as
T6198 1859-1863 VBN denotes seen
T6199 1864-1866 IN denotes in
T6200 1867-1874 JJ denotes frontal
T6201 1875-1883 NNS denotes sections
T6202 1884-1886 IN denotes of
T6203 1887-1890 DT denotes the
T6205 1891-1898 NN denotes control
T6204 1899-1905 NN denotes sample
T6206 1906-1908 IN denotes in
T6207 1909-1913 NN denotes Fig.
T6208 1914-1915 CD denotes 3
T6209 1915-1916 -LRB- denotes (
T6211 1916-1917 NN denotes A
T6212 1917-1918 , denotes ,
T6210 1918-1919 NN denotes C
T6213 1919-1920 -RRB- denotes )
T6214 1920-1921 . denotes .
T6215 1921-2122 sentence denotes Subsequently, the right horn of this structure transforms into the prospective brachiocephalic artery, while the left horn together with the left 4th PAA gives rise to the definitive aortic arch [23].
T6216 1922-1934 RB denotes Subsequently
T6218 1934-1936 , denotes ,
T6219 1936-1939 DT denotes the
T6221 1940-1945 JJ denotes right
T6220 1946-1950 NN denotes horn
T6222 1951-1953 IN denotes of
T6223 1954-1958 DT denotes this
T6224 1959-1968 NN denotes structure
T6217 1969-1979 VBZ denotes transforms
T6225 1980-1984 IN denotes into
T6226 1985-1988 DT denotes the
T6228 1989-2000 JJ denotes prospective
T6229 2001-2016 JJ denotes brachiocephalic
T6227 2017-2023 NN denotes artery
T6230 2023-2025 , denotes ,
T6231 2025-2030 IN denotes while
T6233 2031-2034 DT denotes the
T6235 2035-2039 JJ denotes left
T6234 2040-2044 NN denotes horn
T6236 2045-2053 RB denotes together
T6237 2054-2058 IN denotes with
T6238 2059-2062 DT denotes the
T6240 2063-2067 JJ denotes left
T6241 2068-2071 JJ denotes 4th
T6239 2072-2075 NN denotes PAA
T6232 2076-2081 VBZ denotes gives
T6242 2082-2086 NN denotes rise
T6243 2087-2089 IN denotes to
T6244 2090-2093 DT denotes the
T6246 2094-2104 JJ denotes definitive
T6247 2105-2111 JJ denotes aortic
T6245 2112-2116 NN denotes arch
T6248 2117-2118 -LRB- denotes [
T6249 2118-2120 CD denotes 23
T6250 2120-2121 -RRB- denotes ]
T6251 2121-2122 . denotes .
T6252 2122-2200 sentence denotes In Alk5/Wnt1-Cre mutants, the T-shaped aortic sac failed to form (Fig. 3B,D).
T6253 2123-2125 IN denotes In
T6255 2126-2130 NN denotes Alk5
T6257 2130-2131 HYPH denotes /
T6258 2131-2135 NN denotes Wnt1
T6259 2135-2136 HYPH denotes -
T6256 2136-2139 NN denotes Cre
T6260 2140-2147 NNS denotes mutants
T6261 2147-2149 , denotes ,
T6262 2149-2152 DT denotes the
T6264 2153-2154 NN denotes T
T6266 2154-2155 HYPH denotes -
T6265 2155-2161 VBN denotes shaped
T6267 2162-2168 JJ denotes aortic
T6263 2169-2172 NN denotes sac
T6254 2173-2179 VBD denotes failed
T6268 2180-2182 TO denotes to
T6269 2183-2187 VB denotes form
T6270 2188-2189 -LRB- denotes (
T6272 2189-2193 NN denotes Fig.
T6273 2194-2196 NN denotes 3B
T6274 2196-2197 , denotes ,
T6271 2197-2198 NN denotes D
T6275 2198-2199 -RRB- denotes )
T6276 2199-2200 . denotes .
T6277 2200-2355 sentence denotes Instead, the truncus bifurcated to a left and right arm, which further branched to the PAAs, particularly to the predominant pair of 6th PAAs (Fig. 3B,D).
T6278 2201-2208 RB denotes Instead
T6280 2208-2210 , denotes ,
T6281 2210-2213 DT denotes the
T6282 2214-2221 NN denotes truncus
T6279 2222-2232 VBD denotes bifurcated
T6283 2233-2235 IN denotes to
T6284 2236-2237 DT denotes a
T6286 2238-2242 JJ denotes left
T6287 2243-2246 CC denotes and
T6288 2247-2252 JJ denotes right
T6285 2253-2256 NN denotes arm
T6289 2256-2258 , denotes ,
T6290 2258-2263 WDT denotes which
T6292 2264-2271 RB denotes further
T6291 2272-2280 VBD denotes branched
T6293 2281-2283 IN denotes to
T6294 2284-2287 DT denotes the
T6295 2288-2292 NNS denotes PAAs
T6296 2292-2294 , denotes ,
T6297 2294-2306 RB denotes particularly
T6298 2307-2309 IN denotes to
T6299 2310-2313 DT denotes the
T6301 2314-2325 JJ denotes predominant
T6300 2326-2330 NN denotes pair
T6302 2331-2333 IN denotes of
T6303 2334-2337 JJ denotes 6th
T6304 2338-2342 NNS denotes PAAs
T6305 2343-2344 -LRB- denotes (
T6307 2344-2348 NN denotes Fig.
T6308 2349-2351 NN denotes 3B
T6309 2351-2352 , denotes ,
T6306 2352-2353 NN denotes D
T6310 2353-2354 -RRB- denotes )
T6311 2354-2355 . denotes .
T6312 2355-2615 sentence denotes The observed phenotype is consistent with the absence or severe hypoplasia of structures derived from the aortic sac in late stage embryos (E17), e.g., the missing brachiocephalic artery and severe shortening of the ascending truncus as shown in the Figure 1.
T6313 2356-2359 DT denotes The
T6315 2360-2368 VBN denotes observed
T6314 2369-2378 NN denotes phenotype
T6316 2379-2381 VBZ denotes is
T6317 2382-2392 JJ denotes consistent
T6318 2393-2397 IN denotes with
T6319 2398-2401 DT denotes the
T6320 2402-2409 NN denotes absence
T6321 2410-2412 CC denotes or
T6322 2413-2419 JJ denotes severe
T6323 2420-2430 NN denotes hypoplasia
T6324 2431-2433 IN denotes of
T6325 2434-2444 NNS denotes structures
T6326 2445-2452 VBN denotes derived
T6327 2453-2457 IN denotes from
T6328 2458-2461 DT denotes the
T6330 2462-2468 JJ denotes aortic
T6329 2469-2472 NN denotes sac
T6331 2473-2475 IN denotes in
T6332 2476-2480 JJ denotes late
T6334 2481-2486 NN denotes stage
T6333 2487-2494 NNS denotes embryos
T6335 2495-2496 -LRB- denotes (
T6336 2496-2499 NN denotes E17
T6337 2499-2500 -RRB- denotes )
T6338 2500-2502 , denotes ,
T6339 2502-2506 FW denotes e.g.
T6341 2506-2508 , denotes ,
T6342 2508-2511 DT denotes the
T6343 2512-2519 VBG denotes missing
T6344 2520-2535 JJ denotes brachiocephalic
T6340 2536-2542 NN denotes artery
T6345 2543-2546 CC denotes and
T6346 2547-2553 JJ denotes severe
T6347 2554-2564 NN denotes shortening
T6348 2565-2567 IN denotes of
T6349 2568-2571 DT denotes the
T6351 2572-2581 VBG denotes ascending
T6350 2582-2589 NN denotes truncus
T6352 2590-2592 IN denotes as
T6353 2593-2598 VBN denotes shown
T6354 2599-2601 IN denotes in
T6355 2602-2605 DT denotes the
T6356 2606-2612 NN denotes Figure
T6357 2613-2614 CD denotes 1
T6358 2614-2615 . denotes .
T18564 2626-2634 JJ denotes Abnormal
T18566 2635-2641 JJ denotes Aortic
T18565 2642-2645 NN denotes Sac
T18567 2646-2648 IN denotes in
T18568 2649-2653 NN denotes Alk5
T18570 2653-2654 HYPH denotes /
T18571 2654-2658 NN denotes Wnt1
T18572 2658-2659 HYPH denotes -
T18569 2659-2662 NN denotes Cre
T18573 2663-2670 NNS denotes mutants
T18574 2670-2671 . denotes .
T18575 2671-2789 sentence denotes Alk5/Wnt1-Cre mutants (B, D) fail to form the typical T-shaped structure of the aortic sac seen in controls at E11.5.
T18576 2672-2676 NN denotes Alk5
T18578 2676-2677 HYPH denotes /
T18579 2677-2681 NN denotes Wnt1
T18580 2681-2682 HYPH denotes -
T18577 2682-2685 NN denotes Cre
T18581 2686-2693 NNS denotes mutants
T18583 2694-2695 -LRB- denotes (
T18585 2695-2696 NN denotes B
T18586 2696-2698 , denotes ,
T18584 2698-2699 NN denotes D
T18587 2699-2700 -RRB- denotes )
T18582 2701-2705 VBP denotes fail
T18588 2706-2708 TO denotes to
T18589 2709-2713 VB denotes form
T18590 2714-2717 DT denotes the
T18592 2718-2725 JJ denotes typical
T18593 2726-2727 NN denotes T
T18595 2727-2728 HYPH denotes -
T18594 2728-2734 VBN denotes shaped
T18591 2735-2744 NN denotes structure
T18596 2745-2747 IN denotes of
T18597 2748-2751 DT denotes the
T18599 2752-2758 JJ denotes aortic
T18598 2759-2762 NN denotes sac
T18600 2763-2767 VBN denotes seen
T18601 2768-2770 IN denotes in
T18602 2771-2779 NNS denotes controls
T18603 2780-2782 IN denotes at
T18604 2783-2788 NN denotes E11.5
T18605 2788-2789 . denotes .
T18606 2789-2797 sentence denotes (A, C).
T18607 2790-2791 -LRB- denotes (
T18608 2791-2792 LS denotes A
T18609 2792-2794 , denotes ,
T18610 2794-2795 LS denotes C
T18611 2795-2796 -RRB- denotes )
T18612 2796-2797 . denotes .
T18613 2797-2879 sentence denotes A-B, frontal image of ink-injected embryos; C-D, frontal sections (H&E staining).
T18614 2798-2799 LS denotes A
T18616 2799-2800 SYM denotes -
T18617 2800-2801 LS denotes B
T18618 2801-2803 , denotes ,
T18619 2803-2810 JJ denotes frontal
T18615 2811-2816 NN denotes image
T18620 2817-2819 IN denotes of
T18621 2820-2823 NN denotes ink
T18623 2823-2824 HYPH denotes -
T18622 2824-2832 VBN denotes injected
T18624 2833-2840 NNS denotes embryos
T18625 2840-2841 : denotes ;
T18626 2842-2843 LS denotes C
T18628 2843-2844 SYM denotes -
T18629 2844-2845 LS denotes D
T18630 2845-2847 , denotes ,
T18631 2847-2854 JJ denotes frontal
T18627 2855-2863 NNS denotes sections
T18632 2864-2865 -LRB- denotes (
T18634 2865-2866 NN denotes H
T18635 2866-2867 CC denotes &
T18636 2867-2868 NN denotes E
T18633 2869-2877 NN denotes staining
T18637 2877-2878 -RRB- denotes )
T18638 2878-2879 . denotes .
T18639 2879-3033 sentence denotes Arrows in A and B point to the level of section shown in C and D (red arrows in C and D point to the aortic sac of the control and mutant, respectively).
T18640 2880-2886 NNS denotes Arrows
T18642 2887-2889 IN denotes in
T18643 2890-2891 NN denotes A
T18644 2892-2895 CC denotes and
T18645 2896-2897 NN denotes B
T18641 2898-2903 VBP denotes point
T18647 2904-2906 IN denotes to
T18648 2907-2910 DT denotes the
T18649 2911-2916 NN denotes level
T18650 2917-2919 IN denotes of
T18651 2920-2927 NN denotes section
T18652 2928-2933 VBN denotes shown
T18653 2934-2936 IN denotes in
T18654 2937-2938 NN denotes C
T18655 2939-2942 CC denotes and
T18656 2943-2944 NN denotes D
T18657 2945-2946 -LRB- denotes (
T18658 2946-2949 JJ denotes red
T18659 2950-2956 NNS denotes arrows
T18660 2957-2959 IN denotes in
T18661 2960-2961 NN denotes C
T18662 2962-2965 CC denotes and
T18663 2966-2967 NN denotes D
T18646 2968-2973 VBP denotes point
T18664 2974-2976 IN denotes to
T18665 2977-2980 DT denotes the
T18667 2981-2987 JJ denotes aortic
T18666 2988-2991 NN denotes sac
T18668 2992-2994 IN denotes of
T18669 2995-2998 DT denotes the
T18670 2999-3006 NN denotes control
T18671 3007-3010 CC denotes and
T18672 3011-3017 NN denotes mutant
T18673 3017-3019 , denotes ,
T18674 3019-3031 RB denotes respectively
T18675 3031-3032 -RRB- denotes )
T18676 3032-3033 . denotes .
R1575 T5938 T5939 amod Abnormal,patterning
R1576 T5940 T5939 prep of,patterning
R1577 T5941 T5942 det the,arteries
R1578 T5942 T5940 pobj arteries,of
R1579 T5943 T5942 amod pharyngeal,arteries
R1580 T5944 T5942 compound arch,arteries
R1581 T5945 T5942 cc and,arteries
R1582 T5946 T5947 amod aortic,sac
R1583 T5947 T5942 conj sac,arteries
R1584 T5948 T5939 prep in,patterning
R1585 T5949 T5950 compound Alk5,Wnt1Cre
R1586 T5950 T5952 compound Wnt1Cre,mutants
R1587 T5951 T5950 punct /,Wnt1Cre
R1588 T5952 T5948 pobj mutants,in
R1589 T5954 T5955 prep During,undergo
R1590 T5956 T5957 amod cardiovascular,development
R1591 T5957 T5954 pobj development,During
R1592 T5958 T5955 punct ", ",undergo
R1593 T5959 T5960 det the,PAAs
R1594 T5960 T5955 nsubj PAAs,undergo
R1595 T5961 T5962 det a,set
R1596 T5962 T5955 dobj set,undergo
R1597 T5963 T5962 amod complex,set
R1598 T5964 T5962 prep of,set
R1599 T5965 T5966 amod sequential,steps
R1600 T5966 T5964 pobj steps,of
R1601 T5967 T5966 amod asymmetric,steps
R1602 T5968 T5966 compound remodeling,steps
R1603 T5969 T5962 acl resulting,set
R1604 T5970 T5969 prep in,resulting
R1605 T5971 T5972 det the,arch
R1606 T5972 T5970 pobj arch,in
R1607 T5973 T5974 amod left,sided
R1608 T5974 T5972 amod sided,arch
R1609 T5975 T5974 punct -,sided
R1610 T5976 T5972 amod aortic,arch
R1611 T5977 T5955 punct .,undergo
R1612 T5979 T5980 aux To,determine
R1613 T5980 T5981 advcl determine,performed
R1614 T5982 T5980 punct ", ",determine
R1615 T5983 T5984 mark whether,involved
R1616 T5984 T5980 ccomp involved,determine
R1617 T5985 T5986 npadvmod ALK5,mediated
R1618 T5986 T5988 amod mediated,signaling
R1619 T5987 T5986 punct -,mediated
R1620 T5988 T5984 nsubjpass signaling,involved
R1621 T5989 T5984 auxpass was,involved
R1622 T5990 T5984 prep in,involved
R1623 T5991 T5990 pobj remodeling,in
R1624 T5992 T5991 prep of,remodeling
R1625 T5993 T5992 pobj PAAs,of
R1626 T5994 T5981 punct ", ",performed
R1627 T5995 T5981 nsubj we,performed
R1628 T5996 T5997 amod intracardiac,injections
R1629 T5997 T5981 dobj injections,performed
R1630 T5998 T5999 compound India,ink
R1631 T5999 T5997 compound ink,injections
R1632 T6000 T5981 prep at,performed
R1633 T6001 T6002 amod different,stages
R1634 T6002 T6000 pobj stages,at
R1635 T6003 T6002 amod developmental,stages
R1636 T6004 T5981 punct .,performed
R1637 T6006 T6007 mark While,show
R1638 T6007 T6019 advcl show,became
R1639 T6008 T6007 prep at,show
R1640 T6009 T6008 pobj E10,at
R1641 T6010 T6007 punct ", ",show
R1642 T6011 T6012 compound Alk5,Cre
R1643 T6012 T6016 compound Cre,mutants
R1644 T6013 T6012 punct /,Cre
R1645 T6014 T6012 compound Wnt1,Cre
R1646 T6015 T6012 punct -,Cre
R1647 T6016 T6007 nsubj mutants,show
R1648 T6017 T6007 aux did,show
R1649 T6018 T6007 neg not,show
R1650 T6020 T6021 amod obvious,differences
R1651 T6021 T6007 dobj differences,show
R1652 T6022 T6021 prep in,differences
R1653 T6023 T6024 det the,PAAs
R1654 T6024 T6022 pobj PAAs,in
R1655 T6025 T6019 punct ", ",became
R1656 T6026 T6027 amod abnormal,remodeling
R1657 T6027 T6019 nsubj remodeling,became
R1658 T6028 T6019 acomp obvious,became
R1659 T6029 T6019 prep in,became
R1660 T6030 T6029 pobj mutants,in
R1661 T6031 T6032 det a,day
R1662 T6032 T6033 npadvmod day,later
R1663 T6033 T6019 advmod later,became
R1664 T6034 T6019 prep at,became
R1665 T6035 T6034 pobj E11,at
R1666 T6036 T6037 punct (,Fig.
R1667 T6037 T6019 parataxis Fig.,became
R1668 T6038 T6037 nummod 2,Fig.
R1669 T6039 T6037 punct ),Fig.
R1670 T6040 T6019 punct .,became
R1671 T6042 T6043 det The,controls
R1672 T6043 T6044 nsubj controls,displayed
R1673 T6045 T6046 det the,PAAs
R1674 T6046 T6044 dobj PAAs,displayed
R1675 T6047 T6048 advmod well,formed
R1676 T6048 T6046 amod formed,PAAs
R1677 T6049 T6048 punct -,formed
R1678 T6050 T6046 nmod 3rd,PAAs
R1679 T6051 T6050 punct ", ",3rd
R1680 T6052 T6050 conj 4th,3rd
R1681 T6053 T6052 cc and,4th
R1682 T6054 T6052 conj 6th,4th
R1683 T6055 T6044 punct .,displayed
R1684 T6057 T6058 advmod Moreover,regressing
R1685 T6059 T6058 punct ", ",regressing
R1686 T6060 T6061 det the,duct
R1687 T6061 T6058 nsubj duct,regressing
R1688 T6062 T6061 amod carotid,duct
R1689 T6063 T6061 punct (,duct
R1690 T6064 T6065 det the,aorta
R1691 T6065 T6061 appos aorta,duct
R1692 T6066 T6065 amod dorsal,aorta
R1693 T6067 T6065 prep between,aorta
R1694 T6068 T6069 det the,PAAs
R1695 T6069 T6067 pobj PAAs,between
R1696 T6070 T6069 amod 3rd,PAAs
R1697 T6071 T6070 cc and,3rd
R1698 T6072 T6070 conj 4th,3rd
R1699 T6073 T6058 punct ),regressing
R1700 T6074 T6058 aux was,regressing
R1701 T6075 T6058 advmod already,regressing
R1702 T6076 T6077 mark as,demonstrated
R1703 T6077 T6058 advcl demonstrated,regressing
R1704 T6078 T6077 agent by,demonstrated
R1705 T6079 T6080 det the,size
R1706 T6080 T6078 pobj size,by
R1707 T6081 T6080 amod reduced,size
R1708 T6082 T6083 punct (,2A
R1709 T6083 T6077 parataxis 2A,demonstrated
R1710 T6084 T6083 compound Fig.,2A
R1711 T6085 T6083 punct ),2A
R1712 T6086 T6058 punct .,regressing
R1713 T6088 T6089 prep In,were
R1714 T6090 T6091 compound Alk5,Cre
R1715 T6091 T6095 compound Cre,mutants
R1716 T6092 T6091 punct /,Cre
R1717 T6093 T6091 compound Wnt1,Cre
R1718 T6094 T6091 punct -,Cre
R1719 T6095 T6088 pobj mutants,In
R1720 T6096 T6089 punct ", ",were
R1721 T6097 T6098 det the,pairs
R1722 T6098 T6089 nsubj pairs,were
R1723 T6099 T6098 amod 3rd,pairs
R1724 T6100 T6099 cc and,3rd
R1725 T6101 T6099 conj 4th,3rd
R1726 T6102 T6098 prep of,pairs
R1727 T6103 T6102 pobj PAAs,of
R1728 T6104 T6105 advmod bilaterally,hypoplastic
R1729 T6105 T6089 acomp hypoplastic,were
R1730 T6106 T6089 punct ", ",were
R1731 T6107 T6108 mark whereas,was
R1732 T6108 T6089 advcl was,were
R1733 T6109 T6110 det the,pair
R1734 T6110 T6108 nsubj pair,was
R1735 T6111 T6110 amod 6th,pair
R1736 T6112 T6110 prep of,pair
R1737 T6113 T6112 pobj PAAs,of
R1738 T6114 T6115 advmod notably,hyperplastic
R1739 T6115 T6108 acomp hyperplastic,was
R1740 T6116 T6117 punct (,2B
R1741 T6117 T6108 parataxis 2B,was
R1742 T6118 T6117 compound Fig.,2B
R1743 T6119 T6117 punct ),2B
R1744 T6120 T6089 punct .,were
R1745 T6122 T6123 advmod Furthermore,was
R1746 T6124 T6123 punct ", ",was
R1747 T6125 T6126 det the,duct
R1748 T6126 T6123 nsubj duct,was
R1749 T6127 T6126 amod carotid,duct
R1750 T6128 T6129 advmod remarkably,large
R1751 T6129 T6123 acomp large,was
R1752 T6130 T6123 punct ", ",was
R1753 T6131 T6132 advmod when,compared
R1754 T6132 T6123 advcl compared,was
R1755 T6133 T6132 prep to,compared
R1756 T6134 T6133 pobj controls,to
R1757 T6135 T6123 punct .,was
R1758 T6137 T6138 mark While,displayed
R1759 T6138 T6141 advcl displayed,demonstrated
R1760 T6139 T6140 det the,controls
R1761 T6140 T6138 nsubj controls,displayed
R1762 T6142 T6143 det an,interruption
R1763 T6143 T6138 dobj interruption,displayed
R1764 T6144 T6143 prep of,interruption
R1765 T6145 T6146 det the,duct
R1766 T6146 T6144 pobj duct,of
R1767 T6147 T6146 amod carotid,duct
R1768 T6148 T6138 prep at,displayed
R1769 T6149 T6148 pobj E12,at
R1770 T6150 T6149 cc and,E12
R1771 T6151 T6149 conj E13,E12
R1772 T6152 T6153 mark as,expected
R1773 T6153 T6138 advcl expected,displayed
R1774 T6154 T6155 punct (,2C
R1775 T6155 T6138 parataxis 2C,displayed
R1776 T6156 T6155 compound Fig.,2C
R1777 T6157 T6155 punct ),2C
R1778 T6158 T6141 punct ", ",demonstrated
R1779 T6159 T6160 det the,mutants
R1780 T6160 T6141 nsubj mutants,demonstrated
R1781 T6161 T6162 det an,break
R1782 T6162 T6141 dobj break,demonstrated
R1783 T6163 T6162 amod uncharacteristic,break
R1784 T6164 T6162 prep of,break
R1785 T6165 T6166 det the,aorta
R1786 T6166 T6164 pobj aorta,of
R1787 T6167 T6166 amod dorsal,aorta
R1788 T6168 T6162 prep between,break
R1789 T6169 T6170 det the,pairs
R1790 T6170 T6168 pobj pairs,between
R1791 T6171 T6170 amod 4th,pairs
R1792 T6172 T6171 cc and,4th
R1793 T6173 T6171 conj 6th,4th
R1794 T6174 T6170 prep of,pairs
R1795 T6175 T6174 pobj PAAs,of
R1796 T6176 T6177 punct (,2D
R1797 T6177 T6141 parataxis 2D,demonstrated
R1798 T6178 T6177 compound Fig.,2D
R1799 T6179 T6177 punct ),2D
R1800 T6180 T6141 punct .,demonstrated
R1801 T6182 T6183 prep Around,forms
R1802 T6184 T6182 pobj E11.5,Around
R1803 T6185 T6183 punct ", ",forms
R1804 T6186 T6187 det the,sac
R1805 T6187 T6183 nsubj sac,forms
R1806 T6188 T6187 amod aortic,sac
R1807 T6189 T6183 advmod normally,forms
R1808 T6190 T6191 det a,structure
R1809 T6191 T6183 dobj structure,forms
R1810 T6192 T6191 amod distinctive,structure
R1811 T6193 T6194 npadvmod T,shaped
R1812 T6194 T6191 amod shaped,structure
R1813 T6195 T6194 punct -,shaped
R1814 T6196 T6183 punct ", ",forms
R1815 T6197 T6198 mark as,seen
R1816 T6198 T6183 advcl seen,forms
R1817 T6199 T6198 prep in,seen
R1818 T6200 T6201 amod frontal,sections
R1819 T6201 T6199 pobj sections,in
R1820 T6202 T6201 prep of,sections
R1821 T6203 T6204 det the,sample
R1822 T6204 T6202 pobj sample,of
R1823 T6205 T6204 compound control,sample
R1824 T6206 T6198 prep in,seen
R1825 T6207 T6206 pobj Fig.,in
R1826 T6208 T6207 nummod 3,Fig.
R1827 T6209 T6210 punct (,C
R1828 T6210 T6183 parataxis C,forms
R1829 T6211 T6210 nmod A,C
R1830 T6212 T6210 punct ",",C
R1831 T6213 T6210 punct ),C
R1832 T6214 T6183 punct .,forms
R1833 T6216 T6217 advmod Subsequently,transforms
R1834 T6218 T6217 punct ", ",transforms
R1835 T6219 T6220 det the,horn
R1836 T6220 T6217 nsubj horn,transforms
R1837 T6221 T6220 amod right,horn
R1838 T6222 T6220 prep of,horn
R1839 T6223 T6224 det this,structure
R1840 T6224 T6222 pobj structure,of
R1841 T6225 T6217 prep into,transforms
R1842 T6226 T6227 det the,artery
R1843 T6227 T6225 pobj artery,into
R1844 T6228 T6227 amod prospective,artery
R1845 T6229 T6227 amod brachiocephalic,artery
R1846 T6230 T6217 punct ", ",transforms
R1847 T6231 T6232 mark while,gives
R1848 T6232 T6217 advcl gives,transforms
R1849 T6233 T6234 det the,horn
R1850 T6234 T6232 nsubj horn,gives
R1851 T6235 T6234 amod left,horn
R1852 T6236 T6237 advmod together,with
R1853 T6237 T6234 prep with,horn
R1854 T6238 T6239 det the,PAA
R1855 T6239 T6237 pobj PAA,with
R1856 T6240 T6239 amod left,PAA
R1857 T6241 T6239 amod 4th,PAA
R1858 T6242 T6232 dobj rise,gives
R1859 T6243 T6232 prep to,gives
R1860 T6244 T6245 det the,arch
R1861 T6245 T6243 pobj arch,to
R1862 T6246 T6245 amod definitive,arch
R1863 T6247 T6245 amod aortic,arch
R1864 T6248 T6249 punct [,23
R1865 T6249 T6232 parataxis 23,gives
R1866 T6250 T6249 punct ],23
R1867 T6251 T6217 punct .,transforms
R1868 T6253 T6254 prep In,failed
R1869 T6255 T6256 compound Alk5,Cre
R1870 T6256 T6260 compound Cre,mutants
R1871 T6257 T6256 punct /,Cre
R1872 T6258 T6256 compound Wnt1,Cre
R1873 T6259 T6256 punct -,Cre
R1874 T6260 T6253 pobj mutants,In
R1875 T6261 T6254 punct ", ",failed
R1876 T6262 T6263 det the,sac
R1877 T6263 T6254 nsubj sac,failed
R1878 T6264 T6265 npadvmod T,shaped
R1879 T6265 T6263 amod shaped,sac
R1880 T6266 T6265 punct -,shaped
R1881 T6267 T6263 amod aortic,sac
R1882 T6268 T6269 aux to,form
R1883 T6269 T6254 xcomp form,failed
R1884 T6270 T6271 punct (,D
R1885 T6271 T6269 parataxis D,form
R1886 T6272 T6271 nmod Fig.,D
R1887 T6273 T6271 nmod 3B,D
R1888 T6274 T6271 punct ",",D
R1889 T6275 T6271 punct ),D
R1890 T6276 T6254 punct .,failed
R1891 T6278 T6279 advmod Instead,bifurcated
R1892 T6280 T6279 punct ", ",bifurcated
R1893 T6281 T6282 det the,truncus
R1894 T6282 T6279 nsubj truncus,bifurcated
R1895 T6283 T6279 prep to,bifurcated
R1896 T6284 T6285 det a,arm
R1897 T6285 T6283 pobj arm,to
R1898 T6286 T6285 amod left,arm
R1899 T6287 T6286 cc and,left
R1900 T6288 T6286 conj right,left
R1901 T6289 T6285 punct ", ",arm
R1902 T6290 T6291 dep which,branched
R1903 T6291 T6285 relcl branched,arm
R1904 T6292 T6291 advmod further,branched
R1905 T6293 T6291 prep to,branched
R1906 T6294 T6295 det the,PAAs
R1907 T6295 T6293 pobj PAAs,to
R1908 T6296 T6293 punct ", ",to
R1909 T6297 T6298 advmod particularly,to
R1910 T6298 T6293 prep to,to
R1911 T6299 T6300 det the,pair
R1912 T6300 T6298 pobj pair,to
R1913 T6301 T6300 amod predominant,pair
R1914 T6302 T6300 prep of,pair
R1915 T6303 T6304 amod 6th,PAAs
R1916 T6304 T6302 pobj PAAs,of
R1917 T6305 T6306 punct (,D
R1918 T6306 T6279 parataxis D,bifurcated
R1919 T6307 T6306 nmod Fig.,D
R1920 T6308 T6306 nmod 3B,D
R1921 T6309 T6306 punct ",",D
R1922 T6310 T6306 punct ),D
R1923 T6311 T6279 punct .,bifurcated
R1924 T6313 T6314 det The,phenotype
R1925 T6314 T6316 nsubj phenotype,is
R1926 T6315 T6314 amod observed,phenotype
R1927 T6317 T6316 acomp consistent,is
R1928 T6318 T6317 prep with,consistent
R1929 T6319 T6320 det the,absence
R1930 T6320 T6318 pobj absence,with
R1931 T6321 T6320 cc or,absence
R1932 T6322 T6323 amod severe,hypoplasia
R1933 T6323 T6320 conj hypoplasia,absence
R1934 T6324 T6320 prep of,absence
R1935 T6325 T6324 pobj structures,of
R1936 T6326 T6325 acl derived,structures
R1937 T6327 T6326 prep from,derived
R1938 T6328 T6329 det the,sac
R1939 T6329 T6327 pobj sac,from
R1940 T6330 T6329 amod aortic,sac
R1941 T6331 T6326 prep in,derived
R1942 T6332 T6333 amod late,embryos
R1943 T6333 T6331 pobj embryos,in
R1944 T6334 T6333 compound stage,embryos
R1945 T6335 T6336 punct (,E17
R1946 T6336 T6333 parataxis E17,embryos
R1947 T6337 T6336 punct ),E17
R1948 T6338 T6325 punct ", ",structures
R1949 T6339 T6340 advmod e.g.,artery
R1950 T6340 T6325 appos artery,structures
R1951 T6341 T6340 punct ", ",artery
R1952 T6342 T6340 det the,artery
R1953 T6343 T6340 amod missing,artery
R1954 T6344 T6340 amod brachiocephalic,artery
R1955 T6345 T6340 cc and,artery
R1956 T6346 T6347 amod severe,shortening
R1957 T6347 T6340 conj shortening,artery
R1958 T6348 T6347 prep of,shortening
R1959 T6349 T6350 det the,truncus
R1960 T6350 T6348 pobj truncus,of
R1961 T6351 T6350 amod ascending,truncus
R1962 T6352 T6353 mark as,shown
R1963 T6353 T6316 advcl shown,is
R1964 T6354 T6353 prep in,shown
R1965 T6355 T6356 det the,Figure
R1966 T6356 T6354 pobj Figure,in
R1967 T6357 T6356 nummod 1,Figure
R1968 T6358 T6316 punct .,is
R5521 T18219 T18220 amod Abnormal,patterning
R5522 T18221 T18220 prep of,patterning
R5523 T18222 T18223 det the,PAAs
R5524 T18223 T18221 pobj PAAs,of
R5525 T18224 T18220 prep in,patterning
R5526 T18225 T18226 compound Alk5,Cre
R5527 T18226 T18230 compound Cre,mutants
R5528 T18227 T18226 punct /,Cre
R5529 T18228 T18226 compound Wnt1,Cre
R5530 T18229 T18226 punct -,Cre
R5531 T18230 T18224 pobj mutants,in
R5532 T18231 T18220 punct .,patterning
R5533 T18233 T18234 amod Left,view
R5534 T18235 T18234 amod lateral,view
R5535 T18236 T18234 prep after,view
R5536 T18237 T18238 amod intracardiac,injections
R5537 T18238 T18236 pobj injections,after
R5538 T18239 T18238 compound ink,injections
R5539 T18240 T18241 aux to,visualize
R5540 T18241 T18238 advcl visualize,injections
R5541 T18242 T18243 det the,PAAs
R5542 T18243 T18241 dobj PAAs,visualize
R5543 T18244 T18243 amod developing,PAAs
R5544 T18245 T18241 prep at,visualize
R5545 T18246 T18245 pobj E11.0,at
R5546 T18247 T18248 punct (,B
R5547 T18248 T18246 parataxis B,E11.0
R5548 T18249 T18248 nmod A,B
R5549 T18250 T18248 punct ",",B
R5550 T18251 T18248 punct ),B
R5551 T18252 T18246 punct ", ",E11.0
R5552 T18253 T18246 conj E12.0,E11.0
R5553 T18254 T18255 punct (,D
R5554 T18255 T18253 parataxis D,E12.0
R5555 T18256 T18255 nmod C,D
R5556 T18257 T18255 punct ", ",D
R5557 T18258 T18255 punct ),D
R5558 T18259 T18253 cc and,E12.0
R5559 T18260 T18253 conj E13.0,E12.0
R5560 T18261 T18262 punct (,F
R5561 T18262 T18260 parataxis F,E13.0
R5562 T18263 T18262 nmod E,F
R5563 T18264 T18262 punct ", ",F
R5564 T18265 T18262 punct ),F
R5565 T18266 T18241 prep in,visualize
R5566 T18267 T18266 pobj controls,in
R5567 T18268 T18269 punct (,E
R5568 T18269 T18267 parataxis E,controls
R5569 T18270 T18269 nmod A,E
R5570 T18271 T18269 punct ", ",E
R5571 T18272 T18269 nmod C,E
R5572 T18273 T18269 punct ", ",E
R5573 T18274 T18269 punct ),E
R5574 T18275 T18267 cc and,controls
R5575 T18276 T18277 compound Alk5,Cre
R5576 T18277 T18281 compound Cre,mutants
R5577 T18278 T18277 punct /,Cre
R5578 T18279 T18277 compound Wnt1,Cre
R5579 T18280 T18277 punct -,Cre
R5580 T18281 T18267 conj mutants,controls
R5581 T18282 T18283 punct (,F
R5582 T18283 T18281 parataxis F,mutants
R5583 T18284 T18283 nmod B,F
R5584 T18285 T18283 punct ", ",F
R5585 T18286 T18283 nmod D,F
R5586 T18287 T18283 punct ", ",F
R5587 T18288 T18283 punct ),F
R5588 T18289 T18234 punct .,view
R5589 T18291 T18292 nsubj Arrow,points
R5590 T18293 T18291 prep in,Arrow
R5591 T18294 T18293 pobj A,in
R5592 T18295 T18292 prep to,points
R5593 T18296 T18297 det the,duct
R5594 T18297 T18295 pobj duct,to
R5595 T18298 T18297 amod regressing,duct
R5596 T18299 T18297 amod carotid,duct
R5597 T18300 T18292 punct .,points
R5598 T18302 T18303 nsubj Asterisk,depicts
R5599 T18304 T18302 prep in,Asterisk
R5600 T18305 T18304 pobj B,in
R5601 T18306 T18307 det the,structure
R5602 T18307 T18303 dobj structure,depicts
R5603 T18308 T18307 amod corresponding,structure
R5604 T18309 T18307 prep in,structure
R5605 T18310 T18311 det the,mutant
R5606 T18311 T18309 pobj mutant,in
R5607 T18312 T18303 prep with,depicts
R5608 T18313 T18314 det no,signs
R5609 T18314 T18312 pobj signs,with
R5610 T18315 T18314 prep of,signs
R5611 T18316 T18315 pobj regression,of
R5612 T18317 T18303 punct .,depicts
R5613 T18319 T18320 nsubj Asterisk,illustrates
R5614 T18321 T18319 prep in,Asterisk
R5615 T18322 T18321 pobj D,in
R5616 T18323 T18324 det the,regression
R5617 T18324 T18320 dobj regression,illustrates
R5618 T18325 T18324 amod aberrant,regression
R5619 T18326 T18324 prep of,regression
R5620 T18327 T18328 det the,aorta
R5621 T18328 T18326 pobj aorta,of
R5622 T18329 T18328 amod dorsal,aorta
R5623 T18330 T18324 prep between,regression
R5624 T18331 T18332 det the,PAAs
R5625 T18332 T18330 pobj PAAs,between
R5626 T18333 T18332 amod 4th,PAAs
R5627 T18334 T18333 cc and,4th
R5628 T18335 T18333 conj 6th,4th
R5629 T18336 T18320 punct .,illustrates
R5630 T18339 T18338 punct ", ",PT
R5631 T18340 T18341 amod pulmonary,trunk
R5632 T18341 T18338 appos trunk,PT
R5633 T18342 T18338 punct ;,PT
R5634 T18343 T18338 appos Ao,PT
R5635 T18344 T18343 punct ", ",Ao
R5636 T18345 T18343 appos Aorta,Ao
R5637 T18346 T18338 punct ;,PT
R5638 T18347 T18338 appos TA,PT
R5639 T18348 T18347 punct ", ",TA
R5640 T18349 T18350 compound truncus,arteriosus
R5641 T18350 T18347 appos arteriosus,TA
R5642 T18351 T18338 punct .,PT
R5643 T18564 T18565 amod Abnormal,Sac
R5644 T18566 T18565 amod Aortic,Sac
R5645 T18567 T18565 prep in,Sac
R5646 T18568 T18569 compound Alk5,Cre
R5647 T18569 T18573 compound Cre,mutants
R5648 T18570 T18569 punct /,Cre
R5649 T18571 T18569 compound Wnt1,Cre
R5650 T18572 T18569 punct -,Cre
R5651 T18573 T18567 pobj mutants,in
R5652 T18574 T18565 punct .,Sac
R5653 T18576 T18577 compound Alk5,Cre
R5654 T18577 T18581 compound Cre,mutants
R5655 T18578 T18577 punct /,Cre
R5656 T18579 T18577 compound Wnt1,Cre
R5657 T18580 T18577 punct -,Cre
R5658 T18581 T18582 nsubj mutants,fail
R5659 T18583 T18584 punct (,D
R5660 T18584 T18581 parataxis D,mutants
R5661 T18585 T18584 nmod B,D
R5662 T18586 T18584 punct ", ",D
R5663 T18587 T18584 punct ),D
R5664 T18588 T18589 aux to,form
R5665 T18589 T18582 xcomp form,fail
R5666 T18590 T18591 det the,structure
R5667 T18591 T18589 dobj structure,form
R5668 T18592 T18591 amod typical,structure
R5669 T18593 T18594 npadvmod T,shaped
R5670 T18594 T18591 amod shaped,structure
R5671 T18595 T18594 punct -,shaped
R5672 T18596 T18591 prep of,structure
R5673 T18597 T18598 det the,sac
R5674 T18598 T18596 pobj sac,of
R5675 T18599 T18598 amod aortic,sac
R5676 T18600 T18591 acl seen,structure
R5677 T18601 T18600 prep in,seen
R5678 T18602 T18601 pobj controls,in
R5679 T18603 T18589 prep at,form
R5680 T18604 T18603 pobj E11.5,at
R5681 T18605 T18582 punct .,fail
R5682 T18607 T18608 punct (,A
R5683 T18609 T18608 punct ", ",A
R5684 T18610 T18608 dep C,A
R5685 T18611 T18608 punct ),A
R5686 T18612 T18608 punct .,A
R5687 T18614 T18615 meta A,image
R5688 T18616 T18614 punct -,A
R5689 T18617 T18614 dep B,A
R5690 T18618 T18615 punct ", ",image
R5691 T18619 T18615 amod frontal,image
R5692 T18620 T18615 prep of,image
R5693 T18621 T18622 npadvmod ink,injected
R5694 T18622 T18624 amod injected,embryos
R5695 T18623 T18622 punct -,injected
R5696 T18624 T18620 pobj embryos,of
R5697 T18625 T18615 punct ;,image
R5698 T18626 T18627 meta C,sections
R5699 T18627 T18615 appos sections,image
R5700 T18628 T18626 punct -,C
R5701 T18629 T18626 dep D,C
R5702 T18630 T18627 punct ", ",sections
R5703 T18631 T18627 amod frontal,sections
R5704 T18632 T18633 punct (,staining
R5705 T18633 T18627 parataxis staining,sections
R5706 T18634 T18633 nmod H,staining
R5707 T18635 T18634 cc &,H
R5708 T18636 T18634 conj E,H
R5709 T18637 T18633 punct ),staining
R5710 T18638 T18615 punct .,image
R5711 T18640 T18641 nsubj Arrows,point
R5712 T18641 T18646 ccomp point,point
R5713 T18642 T18640 prep in,Arrows
R5714 T18643 T18642 pobj A,in
R5715 T18644 T18643 cc and,A
R5716 T18645 T18643 conj B,A
R5717 T18647 T18641 prep to,point
R5718 T18648 T18649 det the,level
R5719 T18649 T18647 pobj level,to
R5720 T18650 T18649 prep of,level
R5721 T18651 T18650 pobj section,of
R5722 T18652 T18649 acl shown,level
R5723 T18653 T18652 prep in,shown
R5724 T18654 T18653 pobj C,in
R5725 T18655 T18654 cc and,C
R5726 T18656 T18654 conj D,C
R5727 T18657 T18646 punct (,point
R5728 T18658 T18659 amod red,arrows
R5729 T18659 T18646 nsubj arrows,point
R5730 T18660 T18659 prep in,arrows
R5731 T18661 T18660 pobj C,in
R5732 T18662 T18661 cc and,C
R5733 T18663 T18661 conj D,C
R5734 T18664 T18646 prep to,point
R5735 T18665 T18666 det the,sac
R5736 T18666 T18664 pobj sac,to
R5737 T18667 T18666 amod aortic,sac
R5738 T18668 T18666 prep of,sac
R5739 T18669 T18670 det the,control
R5740 T18670 T18668 pobj control,of
R5741 T18671 T18670 cc and,control
R5742 T18672 T18670 conj mutant,control
R5743 T18673 T18646 punct ", ",point
R5744 T18674 T18646 advmod respectively,point
R5745 T18675 T18646 punct ),point
R5746 T18676 T18646 punct .,point