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PMC:1635039 / 24928-25836 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T14273 0-3 PRP$ denotes Our
T14275 4-11 JJ denotes present
T14274 12-19 NNS denotes results
T14276 20-27 VBP denotes suggest
T14277 28-32 IN denotes that
T14279 33-38 IN denotes while
T14281 39-42 NN denotes TGF
T14283 42-43 HYPH denotes -
T14282 43-44 NN denotes β
T14284 45-54 NN denotes signaling
T14285 55-57 IN denotes in
T14286 58-65 JJ denotes cardiac
T14287 66-70 NNS denotes NCCs
T14288 71-73 VBZ denotes is
T14289 74-87 RB denotes predominantly
T14280 88-96 VBN denotes mediated
T14290 97-100 IN denotes via
T14291 101-104 DT denotes the
T14293 105-109 NN denotes ALK5
T14295 109-110 HYPH denotes /
T14296 110-113 NN denotes TGF
T14297 113-114 HYPH denotes -
T14294 114-118 NN denotes βRII
T14298 119-127 NN denotes receptor
T14292 128-135 NN denotes complex
T14299 135-137 , denotes ,
T14300 137-141 NN denotes ALK5
T14301 142-146 RB denotes also
T14278 147-155 VBZ denotes mediates
T14302 156-165 NN denotes signaling
T14303 166-168 IN denotes of
T14304 169-174 JJ denotes other
T14306 175-182 JJ denotes related
T14305 183-190 NNS denotes ligands
T14307 190-192 , denotes ,
T14308 192-197 WDT denotes which
T14310 198-201 VBP denotes are
T14311 202-208 CC denotes either
T14312 209-217 RB denotes directly
T14313 218-220 CC denotes or
T14314 221-231 RB denotes indirectly
T14309 232-240 VBN denotes required
T14315 241-244 IN denotes for
T14316 245-256 JJ denotes appropriate
T14318 257-260 NN denotes NCC
T14317 261-269 NN denotes survival
T14319 269-270 . denotes .
T14320 270-427 sentence denotes In fact, it has been shown that, besides TGF-βRII, ALK5 can also form a complex with the Activin type IIB receptor to activate downstream Smads 2/3 [18,31].
T14321 271-273 IN denotes In
T14323 274-278 NN denotes fact
T14324 278-280 , denotes ,
T14325 280-282 PRP denotes it
T14326 283-286 VBZ denotes has
T14327 287-291 VBN denotes been
T14322 292-297 VBN denotes shown
T14328 298-302 IN denotes that
T14330 302-304 , denotes ,
T14331 304-311 IN denotes besides
T14332 312-315 NN denotes TGF
T14334 315-316 HYPH denotes -
T14333 316-320 NN denotes βRII
T14335 320-322 , denotes ,
T14336 322-326 NN denotes ALK5
T14337 327-330 MD denotes can
T14338 331-335 RB denotes also
T14329 336-340 VB denotes form
T14339 341-342 DT denotes a
T14340 343-350 NN denotes complex
T14341 351-355 IN denotes with
T14342 356-359 DT denotes the
T14344 360-367 NN denotes Activin
T14345 368-372 NN denotes type
T14346 373-376 NN denotes IIB
T14343 377-385 NN denotes receptor
T14347 386-388 TO denotes to
T14348 389-397 VB denotes activate
T14349 398-408 JJ denotes downstream
T14350 409-414 NNS denotes Smads
T14351 415-416 CD denotes 2
T14352 416-417 HYPH denotes /
T14353 417-418 CD denotes 3
T14354 419-420 -LRB- denotes [
T14356 420-422 CD denotes 18
T14357 422-423 , denotes ,
T14355 423-425 CD denotes 31
T14358 425-426 -RRB- denotes ]
T14359 426-427 . denotes .
T14360 427-584 sentence denotes Furthermore, a subset of TGF-β-related growth and differentiation factors (GDFs), e.g., GDF8, GDF9, GDF11 and GDF15 could induce these events [17,18,32,33].
T14361 428-439 RB denotes Furthermore
T14363 439-441 , denotes ,
T14364 441-442 DT denotes a
T14365 443-449 NN denotes subset
T14366 450-452 IN denotes of
T14367 453-456 NN denotes TGF
T14369 456-457 HYPH denotes -
T14368 457-458 NN denotes β
T14371 458-459 HYPH denotes -
T14370 459-466 VBN denotes related
T14373 467-473 NN denotes growth
T14374 474-477 CC denotes and
T14375 478-493 NN denotes differentiation
T14372 494-501 NNS denotes factors
T14376 502-503 -LRB- denotes (
T14377 503-507 NNS denotes GDFs
T14378 507-508 -RRB- denotes )
T14379 508-510 , denotes ,
T14380 510-514 FW denotes e.g.
T14382 514-516 , denotes ,
T14381 516-520 NN denotes GDF8
T14383 520-522 , denotes ,
T14384 522-526 NN denotes GDF9
T14385 526-528 , denotes ,
T14386 528-533 NN denotes GDF11
T14387 534-537 CC denotes and
T14388 538-543 NN denotes GDF15
T14389 544-549 MD denotes could
T14362 550-556 VB denotes induce
T14390 557-562 DT denotes these
T14391 563-569 NNS denotes events
T14392 570-571 -LRB- denotes [
T14394 571-573 CD denotes 17
T14395 573-574 , denotes ,
T14396 574-576 CD denotes 18
T14397 576-577 , denotes ,
T14398 577-579 CD denotes 32
T14399 579-580 , denotes ,
T14393 580-582 CD denotes 33
T14400 582-583 -RRB- denotes ]
T14401 583-584 . denotes .
T14402 584-908 sentence denotes Although relevant Gdfs 8, 9 11 and 15 are not expressed in the developing heart, nor do the mice deficient in these Gdfs display developmental cardiac defects, we cannot exclude the possibility that circulating GDFs, perhaps in concert with TGF-βs may contribute to NCC survival during cardiac and pharyngeal morphogenesis.
T14403 585-593 IN denotes Although
T14405 594-602 JJ denotes relevant
T14407 603-607 NNS denotes Gdfs
T14406 608-609 CD denotes 8
T14409 609-611 , denotes ,
T14410 611-612 CD denotes 9
T14411 613-615 CD denotes 11
T14412 616-619 CC denotes and
T14413 620-622 CD denotes 15
T14414 623-626 VBP denotes are
T14415 627-630 RB denotes not
T14408 631-640 VBN denotes expressed
T14416 641-643 IN denotes in
T14417 644-647 DT denotes the
T14419 648-658 VBG denotes developing
T14418 659-664 NN denotes heart
T14420 664-666 , denotes ,
T14421 666-669 CC denotes nor
T14422 670-672 VBP denotes do
T14423 673-676 DT denotes the
T14424 677-681 NNS denotes mice
T14425 682-691 JJ denotes deficient
T14426 692-694 IN denotes in
T14427 695-700 DT denotes these
T14428 701-705 NNS denotes Gdfs
T14404 706-713 VB denotes display
T14430 714-727 JJ denotes developmental
T14432 728-735 JJ denotes cardiac
T14431 736-743 NNS denotes defects
T14433 743-745 , denotes ,
T14434 745-747 PRP denotes we
T14435 748-751 MD denotes can
T14436 751-754 RB denotes not
T14429 755-762 VB denotes exclude
T14437 763-766 DT denotes the
T14438 767-778 NN denotes possibility
T14439 779-783 IN denotes that
T14441 784-795 VBG denotes circulating
T14442 796-800 NNS denotes GDFs
T14443 800-802 , denotes ,
T14444 802-809 RB denotes perhaps
T14445 810-812 IN denotes in
T14446 813-820 NN denotes concert
T14447 821-825 IN denotes with
T14448 826-829 NNS denotes TGF
T14450 829-830 HYPH denotes -
T14449 830-832 NNS denotes βs
T14451 833-836 MD denotes may
T14440 837-847 VB denotes contribute
T14452 848-850 IN denotes to
T14453 851-854 NN denotes NCC
T14454 855-863 NN denotes survival
T14455 864-870 IN denotes during
T14456 871-878 JJ denotes cardiac
T14458 879-882 CC denotes and
T14459 883-893 JJ denotes pharyngeal
T14457 894-907 NN denotes morphogenesis
T14460 907-908 . denotes .
R3772 T14273 T14274 poss Our,results
R3773 T14274 T14276 nsubj results,suggest
R3774 T14275 T14274 amod present,results
R3775 T14277 T14278 mark that,mediates
R3776 T14278 T14276 ccomp mediates,suggest
R3777 T14279 T14280 mark while,mediated
R3778 T14280 T14278 advcl mediated,mediates
R3779 T14281 T14282 compound TGF,β
R3780 T14282 T14284 compound β,signaling
R3781 T14283 T14282 punct -,β
R3782 T14284 T14280 nsubjpass signaling,mediated
R3783 T14285 T14284 prep in,signaling
R3784 T14286 T14287 amod cardiac,NCCs
R3785 T14287 T14285 pobj NCCs,in
R3786 T14288 T14280 auxpass is,mediated
R3787 T14289 T14280 advmod predominantly,mediated
R3788 T14290 T14280 prep via,mediated
R3789 T14291 T14292 det the,complex
R3790 T14292 T14290 pobj complex,via
R3791 T14293 T14294 compound ALK5,βRII
R3792 T14294 T14298 compound βRII,receptor
R3793 T14295 T14294 punct /,βRII
R3794 T14296 T14294 compound TGF,βRII
R3795 T14297 T14294 punct -,βRII
R3796 T14298 T14292 compound receptor,complex
R3797 T14299 T14278 punct ", ",mediates
R3798 T14300 T14278 nsubj ALK5,mediates
R3799 T14301 T14278 advmod also,mediates
R3800 T14302 T14278 dobj signaling,mediates
R3801 T14303 T14302 prep of,signaling
R3802 T14304 T14305 amod other,ligands
R3803 T14305 T14303 pobj ligands,of
R3804 T14306 T14305 amod related,ligands
R3805 T14307 T14305 punct ", ",ligands
R3806 T14308 T14309 dep which,required
R3807 T14309 T14305 relcl required,ligands
R3808 T14310 T14309 auxpass are,required
R3809 T14311 T14312 preconj either,directly
R3810 T14312 T14309 advmod directly,required
R3811 T14361 T14362 advmod Furthermore,induce
R3812 T14313 T14312 cc or,directly
R3813 T14363 T14362 punct ", ",induce
R3814 T14314 T14312 conj indirectly,directly
R3815 T14364 T14365 det a,subset
R3816 T14365 T14362 nsubj subset,induce
R3817 T14315 T14309 prep for,required
R3818 T14366 T14365 prep of,subset
R3819 T14367 T14368 compound TGF,β
R3820 T14368 T14370 npadvmod β,related
R3821 T14316 T14317 amod appropriate,survival
R3822 T14369 T14368 punct -,β
R3823 T14370 T14372 amod related,factors
R3824 T14317 T14315 pobj survival,for
R3825 T14371 T14370 punct -,related
R3826 T14372 T14366 pobj factors,of
R3827 T14373 T14372 nmod growth,factors
R3828 T14318 T14317 compound NCC,survival
R3829 T14374 T14373 cc and,growth
R3830 T14375 T14373 conj differentiation,growth
R3831 T14376 T14372 punct (,factors
R3832 T14319 T14276 punct .,suggest
R3833 T14377 T14372 appos GDFs,factors
R3834 T14378 T14365 punct ),subset
R3835 T14379 T14365 punct ", ",subset
R3836 T14321 T14322 prep In,shown
R3837 T14380 T14381 advmod e.g.,GDF8
R3838 T14381 T14365 appos GDF8,subset
R3839 T14382 T14381 punct ", ",GDF8
R3840 T14383 T14381 punct ", ",GDF8
R3841 T14323 T14321 pobj fact,In
R3842 T14384 T14381 conj GDF9,GDF8
R3843 T14385 T14384 punct ", ",GDF9
R3844 T14386 T14384 conj GDF11,GDF9
R3845 T14387 T14386 cc and,GDF11
R3846 T14388 T14386 conj GDF15,GDF11
R3847 T14389 T14362 aux could,induce
R3848 T14324 T14322 punct ", ",shown
R3849 T14390 T14391 det these,events
R3850 T14391 T14362 dobj events,induce
R3851 T14325 T14322 nsubjpass it,shown
R3852 T14392 T14393 punct [,33
R3853 T14393 T14362 parataxis 33,induce
R3854 T14394 T14393 nummod 17,33
R3855 T14395 T14393 punct ",",33
R3856 T14396 T14393 nummod 18,33
R3857 T14326 T14322 aux has,shown
R3858 T14397 T14393 punct ",",33
R3859 T14398 T14393 nummod 32,33
R3860 T14399 T14393 punct ",",33
R3861 T14327 T14322 auxpass been,shown
R3862 T14400 T14393 punct ],33
R3863 T14401 T14362 punct .,induce
R3864 T14328 T14329 mark that,form
R3865 T14329 T14322 ccomp form,shown
R3866 T14403 T14404 mark Although,display
R3867 T14330 T14329 punct ", ",form
R3868 T14404 T14429 advcl display,exclude
R3869 T14405 T14406 amod relevant,8
R3870 T14331 T14329 prep besides,form
R3871 T14406 T14408 nsubjpass 8,expressed
R3872 T14407 T14406 nmod Gdfs,8
R3873 T14408 T14404 ccomp expressed,display
R3874 T14332 T14333 compound TGF,βRII
R3875 T14409 T14406 punct ", ",8
R3876 T14410 T14411 nummod 9,11
R3877 T14333 T14331 pobj βRII,besides
R3878 T14411 T14406 conj 11,8
R3879 T14412 T14411 cc and,11
R3880 T14413 T14411 conj 15,11
R3881 T14334 T14333 punct -,βRII
R3882 T14414 T14408 auxpass are,expressed
R3883 T14415 T14408 neg not,expressed
R3884 T14335 T14329 punct ", ",form
R3885 T14416 T14408 prep in,expressed
R3886 T14417 T14418 det the,heart
R3887 T14418 T14416 pobj heart,in
R3888 T14336 T14329 nsubj ALK5,form
R3889 T14419 T14418 amod developing,heart
R3890 T14420 T14404 punct ", ",display
R3891 T14421 T14404 cc nor,display
R3892 T14337 T14329 aux can,form
R3893 T14422 T14404 aux do,display
R3894 T14423 T14424 det the,mice
R3895 T14424 T14404 nsubj mice,display
R3896 T14425 T14424 amod deficient,mice
R3897 T14426 T14425 prep in,deficient
R3898 T14338 T14329 advmod also,form
R3899 T14427 T14428 det these,Gdfs
R3900 T14428 T14426 pobj Gdfs,in
R3901 T14339 T14340 det a,complex
R3902 T14430 T14431 amod developmental,defects
R3903 T14431 T14404 dobj defects,display
R3904 T14340 T14329 dobj complex,form
R3905 T14432 T14431 amod cardiac,defects
R3906 T14341 T14340 prep with,complex
R3907 T14433 T14429 punct ", ",exclude
R3908 T14434 T14429 nsubj we,exclude
R3909 T14435 T14429 aux can,exclude
R3910 T14436 T14429 neg not,exclude
R3911 T14342 T14343 det the,receptor
R3912 T14437 T14438 det the,possibility
R3913 T14438 T14429 dobj possibility,exclude
R3914 T14439 T14440 mark that,contribute
R3915 T14343 T14341 pobj receptor,with
R3916 T14440 T14438 acl contribute,possibility
R3917 T14441 T14442 amod circulating,GDFs
R3918 T14344 T14343 compound Activin,receptor
R3919 T14442 T14440 nsubj GDFs,contribute
R3920 T14443 T14442 punct ", ",GDFs
R3921 T14444 T14445 advmod perhaps,in
R3922 T14345 T14346 compound type,IIB
R3923 T14445 T14442 prep in,GDFs
R3924 T14446 T14445 pobj concert,in
R3925 T14447 T14446 prep with,concert
R3926 T14346 T14343 compound IIB,receptor
R3927 T14448 T14449 compound TGF,βs
R3928 T14449 T14447 pobj βs,with
R3929 T14450 T14449 punct -,βs
R3930 T14347 T14348 aux to,activate
R3931 T14451 T14440 aux may,contribute
R3932 T14452 T14440 prep to,contribute
R3933 T14453 T14454 compound NCC,survival
R3934 T14348 T14329 advcl activate,form
R3935 T14454 T14452 pobj survival,to
R3936 T14455 T14440 prep during,contribute
R3937 T14456 T14457 amod cardiac,morphogenesis
R3938 T14349 T14350 amod downstream,Smads
R3939 T14457 T14455 pobj morphogenesis,during
R3940 T14458 T14456 cc and,cardiac
R3941 T14459 T14456 conj pharyngeal,cardiac
R3942 T14350 T14348 dobj Smads,activate
R3943 T14460 T14429 punct .,exclude
R3944 T14351 T14350 nummod 2,Smads
R3946 T14352 T14350 punct /,Smads
R3949 T14353 T14350 nummod 3,Smads
R3950 T14354 T14355 punct [,31
R3953 T14355 T14329 parataxis 31,form
R3957 T14356 T14355 nummod 18,31
R3961 T14357 T14355 punct ",",31
R3963 T14358 T14355 punct ],31
R3968 T14359 T14322 punct .,shown