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PMC:1635039 / 20885-22233 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function

Id Subject Object Predicate Lexical cue
T10819 0-2 IN denotes In
T10821 3-11 NN denotes addition
T10822 12-14 IN denotes to
T10823 15-18 DT denotes the
T10825 19-26 JJ denotes cardiac
T10824 27-30 NN denotes OFT
T10826 30-32 , denotes ,
T10827 32-43 NN denotes development
T10828 44-46 IN denotes of
T10829 47-57 JJ denotes pharyngeal
T10830 58-64 NNS denotes organs
T10831 64-66 , denotes ,
T10832 66-70 FW denotes i.e.
T10834 70-72 , denotes ,
T10835 72-75 DT denotes the
T10836 76-87 JJ denotes parathyroid
T10833 88-94 NNS denotes glands
T10837 95-98 CC denotes and
T10838 99-102 DT denotes the
T10839 103-109 NN denotes thymus
T10820 110-113 VBD denotes was
T10840 114-118 RB denotes also
T10841 119-127 JJ denotes abnormal
T10842 128-130 IN denotes in
T10843 131-135 NN denotes Alk5
T10845 135-136 HYPH denotes /
T10846 136-140 NN denotes Wnt1
T10847 140-141 HYPH denotes -
T10844 141-144 NN denotes Cre
T10848 145-152 NNS denotes mutants
T10849 153-154 -LRB- denotes (
T10850 154-157 VB denotes see
T10851 158-163 NNS denotes Figs.
T10852 164-165 CD denotes 1
T10853 166-169 CC denotes and
T10854 170-171 CD denotes 8
T10855 171-172 -RRB- denotes )
T10856 172-173 . denotes .
T10857 173-355 sentence denotes Normally the thymus develops from the third pharyngeal pouch endoderm and migrates caudally to its final location in the superior mediastinum as seen in controls at E14 (Fig. 8A,B).
T10858 174-182 RB denotes Normally
T10860 183-186 DT denotes the
T10861 187-193 NN denotes thymus
T10859 194-202 VBZ denotes develops
T10862 203-207 IN denotes from
T10863 208-211 DT denotes the
T10865 212-217 JJ denotes third
T10866 218-228 JJ denotes pharyngeal
T10867 229-234 NN denotes pouch
T10864 235-243 NN denotes endoderm
T10868 244-247 CC denotes and
T10869 248-256 VBZ denotes migrates
T10870 257-265 RB denotes caudally
T10871 266-268 IN denotes to
T10872 269-272 PRP$ denotes its
T10874 273-278 JJ denotes final
T10873 279-287 NN denotes location
T10875 288-290 IN denotes in
T10876 291-294 DT denotes the
T10878 295-303 JJ denotes superior
T10877 304-315 NN denotes mediastinum
T10879 316-318 IN denotes as
T10880 319-323 VBN denotes seen
T10881 324-326 IN denotes in
T10882 327-335 NNS denotes controls
T10883 336-338 IN denotes at
T10884 339-342 NN denotes E14
T10885 343-344 -LRB- denotes (
T10887 344-348 NN denotes Fig.
T10888 349-351 NN denotes 8A
T10889 351-352 , denotes ,
T10886 352-353 NN denotes B
T10890 353-354 -RRB- denotes )
T10891 354-355 . denotes .
T10892 355-572 sentence denotes In contrast, the thymic primordia of the Alk5 mutant littermates failed to descend caudally, and were located bilaterally in the neck region, where they were surrounded by neural crest-derived mesenchyme (Fig. 8D,E).
T10893 356-358 IN denotes In
T10895 359-367 NN denotes contrast
T10896 367-369 , denotes ,
T10897 369-372 DT denotes the
T10899 373-379 JJ denotes thymic
T10898 380-389 NNS denotes primordia
T10900 390-392 IN denotes of
T10901 393-396 DT denotes the
T10903 397-401 NN denotes Alk5
T10904 402-408 NN denotes mutant
T10902 409-420 NNS denotes littermates
T10894 421-427 VBD denotes failed
T10905 428-430 TO denotes to
T10906 431-438 VB denotes descend
T10907 439-447 RB denotes caudally
T10908 447-449 , denotes ,
T10909 449-452 CC denotes and
T10910 453-457 VBD denotes were
T10911 458-465 VBN denotes located
T10912 466-477 RB denotes bilaterally
T10913 478-480 IN denotes in
T10914 481-484 DT denotes the
T10916 485-489 NN denotes neck
T10915 490-496 NN denotes region
T10917 496-498 , denotes ,
T10918 498-503 WRB denotes where
T10920 504-508 PRP denotes they
T10921 509-513 VBD denotes were
T10919 514-524 VBN denotes surrounded
T10922 525-527 IN denotes by
T10923 528-534 JJ denotes neural
T10924 535-540 NN denotes crest
T10926 540-541 HYPH denotes -
T10925 541-548 VBN denotes derived
T10927 549-559 NN denotes mesenchyme
T10928 560-561 -LRB- denotes (
T10930 561-565 NN denotes Fig.
T10931 566-568 NN denotes 8D
T10932 568-569 , denotes ,
T10929 569-570 NN denotes E
T10933 570-571 -RRB- denotes )
T10934 571-572 . denotes .
T10935 572-718 sentence denotes The fate determination assay demonstrated that the thymic primordia were equally populated by NCCs both in controls and Alk5 mutants (Fig. 8B,E).
T10936 573-576 DT denotes The
T10938 577-581 NN denotes fate
T10939 582-595 NN denotes determination
T10937 596-601 NN denotes assay
T10940 602-614 VBD denotes demonstrated
T10941 615-619 IN denotes that
T10943 620-623 DT denotes the
T10945 624-630 JJ denotes thymic
T10944 631-640 NNS denotes primordia
T10946 641-645 VBD denotes were
T10947 646-653 RB denotes equally
T10942 654-663 VBN denotes populated
T10948 664-666 IN denotes by
T10949 667-671 NNS denotes NCCs
T10950 672-676 CC denotes both
T10951 677-679 IN denotes in
T10952 680-688 NNS denotes controls
T10953 689-692 CC denotes and
T10954 693-697 NN denotes Alk5
T10955 698-705 NNS denotes mutants
T10956 706-707 -LRB- denotes (
T10958 707-711 NN denotes Fig.
T10959 712-714 NN denotes 8B
T10960 714-715 , denotes ,
T10957 715-716 NN denotes E
T10961 716-717 -RRB- denotes )
T10962 717-718 . denotes .
T10963 718-803 sentence denotes Likewise the parathyroid glands failed to migrate normally in Alk5/Wnt1-Cre mutants.
T10964 719-727 RB denotes Likewise
T10966 728-731 DT denotes the
T10968 732-743 JJ denotes parathyroid
T10967 744-750 NNS denotes glands
T10965 751-757 VBD denotes failed
T10969 758-760 TO denotes to
T10970 761-768 VB denotes migrate
T10971 769-777 RB denotes normally
T10972 778-780 IN denotes in
T10973 781-785 NN denotes Alk5
T10975 785-786 HYPH denotes /
T10976 786-790 NN denotes Wnt1
T10977 790-791 HYPH denotes -
T10974 791-794 NN denotes Cre
T10978 795-802 NNS denotes mutants
T10979 802-803 . denotes .
T10980 803-971 sentence denotes During normal development, the parathyroids first migrate in association with the thymic primordia, until they reach the thyroids in the neck region as seen in Fig 8C.
T10981 804-810 IN denotes During
T10983 811-817 JJ denotes normal
T10984 818-829 NN denotes development
T10985 829-831 , denotes ,
T10986 831-834 DT denotes the
T10987 835-847 NNS denotes parathyroids
T10988 848-853 RB denotes first
T10982 854-861 VBP denotes migrate
T10989 862-864 IN denotes in
T10990 865-876 NN denotes association
T10991 877-881 IN denotes with
T10992 882-885 DT denotes the
T10994 886-892 JJ denotes thymic
T10993 893-902 NNS denotes primordia
T10995 902-904 , denotes ,
T10996 904-909 IN denotes until
T10998 910-914 PRP denotes they
T10997 915-920 VBP denotes reach
T10999 921-924 DT denotes the
T11000 925-933 NNS denotes thyroids
T11001 934-936 IN denotes in
T11002 937-940 DT denotes the
T11004 941-945 NN denotes neck
T11003 946-952 NN denotes region
T11005 953-955 IN denotes as
T11006 956-960 VBN denotes seen
T11007 961-963 IN denotes in
T11008 964-967 NN denotes Fig
T11009 968-970 NN denotes 8C
T11010 970-971 . denotes .
T11011 971-1215 sentence denotes In Alk5/Wnt1-Cre mutants, the parathyroids remained associated with the thymic primordia, and despite this abnormal rostral location, expression of parathyroid hormone was indistinguishable between Alk5 mutants and controls at E14 (Fig. 8C,F).
T11012 972-974 IN denotes In
T11014 975-979 NN denotes Alk5
T11016 979-980 HYPH denotes /
T11017 980-984 NN denotes Wnt1
T11018 984-985 HYPH denotes -
T11015 985-988 NN denotes Cre
T11019 989-996 NNS denotes mutants
T11020 996-998 , denotes ,
T11021 998-1001 DT denotes the
T11022 1002-1014 NNS denotes parathyroids
T11013 1015-1023 VBD denotes remained
T11023 1024-1034 JJ denotes associated
T11024 1035-1039 IN denotes with
T11025 1040-1043 DT denotes the
T11027 1044-1050 JJ denotes thymic
T11026 1051-1060 NNS denotes primordia
T11028 1060-1062 , denotes ,
T11029 1062-1065 CC denotes and
T11030 1066-1073 IN denotes despite
T11032 1074-1078 DT denotes this
T11034 1079-1087 JJ denotes abnormal
T11035 1088-1095 JJ denotes rostral
T11033 1096-1104 NN denotes location
T11036 1104-1106 , denotes ,
T11037 1106-1116 NN denotes expression
T11038 1117-1119 IN denotes of
T11039 1120-1131 NN denotes parathyroid
T11040 1132-1139 NN denotes hormone
T11031 1140-1143 VBD denotes was
T11041 1144-1161 JJ denotes indistinguishable
T11042 1162-1169 IN denotes between
T11043 1170-1174 NN denotes Alk5
T11044 1175-1182 NNS denotes mutants
T11045 1183-1186 CC denotes and
T11046 1187-1195 NNS denotes controls
T11047 1196-1198 IN denotes at
T11048 1199-1202 NN denotes E14
T11049 1203-1204 -LRB- denotes (
T11051 1204-1208 NN denotes Fig.
T11052 1209-1211 NN denotes 8C
T11053 1211-1212 , denotes ,
T11050 1212-1213 NN denotes F
T11054 1213-1214 -RRB- denotes )
T11055 1214-1215 . denotes .
T11056 1215-1348 sentence denotes To conclude, the observed pharyngeal organ phenotypes were also in striking contrast to those seen in Tgfbr2/Wnt1-Cre mutants [8,9].
T11057 1216-1218 TO denotes To
T11058 1219-1227 VB denotes conclude
T11060 1227-1229 , denotes ,
T11061 1229-1232 DT denotes the
T11063 1233-1241 VBN denotes observed
T11064 1242-1252 JJ denotes pharyngeal
T11065 1253-1258 NN denotes organ
T11062 1259-1269 NNS denotes phenotypes
T11059 1270-1274 VBD denotes were
T11066 1275-1279 RB denotes also
T11067 1280-1282 IN denotes in
T11068 1283-1291 NN denotes striking
T11069 1292-1300 NN denotes contrast
T11070 1301-1303 IN denotes to
T11071 1304-1309 DT denotes those
T11072 1310-1314 VBN denotes seen
T11073 1315-1317 IN denotes in
T11074 1318-1324 NN denotes Tgfbr2
T11076 1324-1325 HYPH denotes /
T11077 1325-1329 NN denotes Wnt1
T11078 1329-1330 HYPH denotes -
T11075 1330-1333 NN denotes Cre
T11079 1334-1341 NNS denotes mutants
T11080 1342-1343 -LRB- denotes [
T11082 1343-1344 CD denotes 8
T11083 1344-1345 , denotes ,
T11081 1345-1346 CD denotes 9
T11084 1346-1347 -RRB- denotes ]
T11085 1347-1348 . denotes .
R3179 T10819 T10820 prep In,was
R3180 T10821 T10819 pobj addition,In
R3181 T10822 T10821 prep to,addition
R3182 T10823 T10824 det the,OFT
R3183 T10824 T10822 pobj OFT,to
R3184 T10825 T10824 amod cardiac,OFT
R3185 T10826 T10820 punct ", ",was
R3186 T10827 T10820 nsubj development,was
R3187 T10828 T10827 prep of,development
R3188 T10829 T10830 amod pharyngeal,organs
R3189 T10830 T10828 pobj organs,of
R3190 T10831 T10827 punct ", ",development
R3191 T10832 T10833 advmod i.e.,glands
R3192 T10833 T10827 appos glands,development
R3193 T10834 T10833 punct ", ",glands
R3194 T10835 T10833 det the,glands
R3195 T10836 T10833 amod parathyroid,glands
R3196 T10837 T10833 cc and,glands
R3197 T10838 T10839 det the,thymus
R3198 T10839 T10833 conj thymus,glands
R3199 T10840 T10820 advmod also,was
R3200 T10841 T10820 acomp abnormal,was
R3201 T10842 T10820 prep in,was
R3202 T10843 T10844 compound Alk5,Cre
R3203 T10844 T10848 compound Cre,mutants
R3204 T10845 T10844 punct /,Cre
R3205 T10846 T10844 compound Wnt1,Cre
R3206 T10847 T10844 punct -,Cre
R3207 T10848 T10842 pobj mutants,in
R3208 T10849 T10850 punct (,see
R3209 T10850 T10820 parataxis see,was
R3210 T10851 T10852 nmod Figs.,1
R3211 T10852 T10850 dobj 1,see
R3212 T10853 T10852 cc and,1
R3213 T10854 T10852 conj 8,1
R3214 T10855 T10850 punct ),see
R3215 T10856 T10820 punct .,was
R3216 T10858 T10859 advmod Normally,develops
R3217 T10860 T10861 det the,thymus
R3218 T10861 T10859 nsubj thymus,develops
R3219 T10862 T10859 prep from,develops
R3220 T10863 T10864 det the,endoderm
R3221 T10864 T10862 pobj endoderm,from
R3222 T10865 T10864 amod third,endoderm
R3223 T10866 T10864 amod pharyngeal,endoderm
R3224 T10867 T10864 compound pouch,endoderm
R3225 T10868 T10859 cc and,develops
R3226 T10869 T10859 conj migrates,develops
R3227 T10870 T10869 advmod caudally,migrates
R3228 T10871 T10869 prep to,migrates
R3229 T10872 T10873 poss its,location
R3230 T10873 T10871 pobj location,to
R3231 T10874 T10873 amod final,location
R3232 T10875 T10873 prep in,location
R3233 T10876 T10877 det the,mediastinum
R3234 T10877 T10875 pobj mediastinum,in
R3235 T10878 T10877 amod superior,mediastinum
R3236 T10879 T10880 mark as,seen
R3237 T10880 T10869 advcl seen,migrates
R3238 T10881 T10880 prep in,seen
R3239 T10882 T10881 pobj controls,in
R3240 T10883 T10869 prep at,migrates
R3241 T10884 T10883 pobj E14,at
R3242 T10885 T10886 punct (,B
R3243 T10886 T10869 parataxis B,migrates
R3244 T10887 T10886 nmod Fig.,B
R3245 T10888 T10886 nmod 8A,B
R3246 T10889 T10886 punct ",",B
R3247 T10890 T10886 punct ),B
R3248 T10891 T10859 punct .,develops
R3249 T10893 T10894 prep In,failed
R3250 T10895 T10893 pobj contrast,In
R3251 T10896 T10894 punct ", ",failed
R3252 T10897 T10898 det the,primordia
R3253 T10898 T10894 nsubj primordia,failed
R3254 T10899 T10898 amod thymic,primordia
R3255 T10900 T10898 prep of,primordia
R3256 T10901 T10902 det the,littermates
R3257 T10902 T10900 pobj littermates,of
R3258 T10903 T10902 compound Alk5,littermates
R3259 T10904 T10902 compound mutant,littermates
R3260 T10905 T10906 aux to,descend
R3261 T10906 T10894 xcomp descend,failed
R3262 T10907 T10906 advmod caudally,descend
R3263 T10908 T10894 punct ", ",failed
R3264 T10909 T10894 cc and,failed
R3265 T10910 T10911 auxpass were,located
R3266 T10911 T10894 conj located,failed
R3267 T10912 T10911 advmod bilaterally,located
R3268 T10913 T10911 prep in,located
R3269 T10914 T10915 det the,region
R3270 T10915 T10913 pobj region,in
R3271 T10916 T10915 compound neck,region
R3272 T10917 T10915 punct ", ",region
R3273 T10918 T10919 advmod where,surrounded
R3274 T10919 T10915 relcl surrounded,region
R3275 T10920 T10919 nsubjpass they,surrounded
R3276 T10921 T10919 auxpass were,surrounded
R3277 T10922 T10919 agent by,surrounded
R3278 T10923 T10924 amod neural,crest
R3279 T10924 T10925 npadvmod crest,derived
R3280 T10925 T10927 amod derived,mesenchyme
R3281 T10926 T10925 punct -,derived
R3282 T10927 T10922 pobj mesenchyme,by
R3283 T10928 T10929 punct (,E
R3284 T10929 T10911 parataxis E,located
R3285 T10930 T10929 nmod Fig.,E
R3286 T10931 T10929 nmod 8D,E
R3287 T10932 T10929 punct ",",E
R3288 T10933 T10929 punct ),E
R3289 T10934 T10894 punct .,failed
R3290 T10936 T10937 det The,assay
R3291 T10937 T10940 nsubj assay,demonstrated
R3292 T10938 T10939 compound fate,determination
R3293 T10939 T10937 compound determination,assay
R3294 T10941 T10942 mark that,populated
R3295 T10942 T10940 ccomp populated,demonstrated
R3296 T10943 T10944 det the,primordia
R3297 T10944 T10942 nsubjpass primordia,populated
R3298 T10945 T10944 amod thymic,primordia
R3299 T10946 T10942 auxpass were,populated
R3300 T10947 T10942 advmod equally,populated
R3301 T10948 T10942 agent by,populated
R3302 T10949 T10948 pobj NCCs,by
R3303 T10950 T10951 preconj both,in
R3304 T10951 T10942 prep in,populated
R3305 T10952 T10951 pobj controls,in
R3306 T10953 T10952 cc and,controls
R3307 T10954 T10955 compound Alk5,mutants
R3308 T10955 T10952 conj mutants,controls
R3309 T10956 T10957 punct (,E
R3310 T10957 T10942 parataxis E,populated
R3311 T10958 T10957 nmod Fig.,E
R3312 T10959 T10957 nmod 8B,E
R3313 T10960 T10957 punct ",",E
R3314 T10961 T10957 punct ),E
R3315 T10962 T10940 punct .,demonstrated
R3316 T10964 T10965 advmod Likewise,failed
R3317 T10966 T10967 det the,glands
R3318 T10967 T10965 nsubj glands,failed
R3319 T10968 T10967 amod parathyroid,glands
R3320 T10969 T10970 aux to,migrate
R3321 T10970 T10965 xcomp migrate,failed
R3322 T10971 T10970 advmod normally,migrate
R3323 T10972 T10970 prep in,migrate
R3324 T10973 T10974 compound Alk5,Cre
R3325 T10974 T10978 compound Cre,mutants
R3326 T10975 T10974 punct /,Cre
R3327 T10976 T10974 compound Wnt1,Cre
R3328 T10977 T10974 punct -,Cre
R3329 T10978 T10972 pobj mutants,in
R3330 T10979 T10965 punct .,failed
R3331 T10981 T10982 prep During,migrate
R3332 T10983 T10984 amod normal,development
R3333 T10984 T10981 pobj development,During
R3334 T10985 T10982 punct ", ",migrate
R3335 T10986 T10987 det the,parathyroids
R3336 T10987 T10982 nsubj parathyroids,migrate
R3337 T10988 T10982 advmod first,migrate
R3338 T10989 T10982 prep in,migrate
R3339 T10990 T10989 pobj association,in
R3340 T10991 T10990 prep with,association
R3341 T10992 T10993 det the,primordia
R3342 T10993 T10991 pobj primordia,with
R3343 T10994 T10993 amod thymic,primordia
R3344 T10995 T10982 punct ", ",migrate
R3345 T10996 T10997 mark until,reach
R3346 T10997 T10982 advcl reach,migrate
R3347 T10998 T10997 nsubj they,reach
R3348 T10999 T11000 det the,thyroids
R3349 T11000 T10997 dobj thyroids,reach
R3350 T11001 T11000 prep in,thyroids
R3351 T11002 T11003 det the,region
R3352 T11003 T11001 pobj region,in
R3353 T11004 T11003 compound neck,region
R3354 T11005 T11006 mark as,seen
R3355 T11006 T10997 advcl seen,reach
R3356 T11007 T11006 prep in,seen
R3357 T11008 T11009 compound Fig,8C
R3358 T11009 T11007 pobj 8C,in
R3359 T11010 T10982 punct .,migrate
R3360 T11012 T11013 prep In,remained
R3361 T11014 T11015 compound Alk5,Cre
R3362 T11015 T11019 compound Cre,mutants
R3363 T11016 T11015 punct /,Cre
R3364 T11017 T11015 compound Wnt1,Cre
R3365 T11018 T11015 punct -,Cre
R3366 T11019 T11012 pobj mutants,In
R3367 T11020 T11013 punct ", ",remained
R3368 T11021 T11022 det the,parathyroids
R3369 T11022 T11013 nsubj parathyroids,remained
R3370 T11023 T11013 acomp associated,remained
R3371 T11024 T11023 prep with,associated
R3372 T11025 T11026 det the,primordia
R3373 T11026 T11024 pobj primordia,with
R3374 T11027 T11026 amod thymic,primordia
R3375 T11028 T11013 punct ", ",remained
R3376 T11029 T11013 cc and,remained
R3377 T11030 T11031 prep despite,was
R3378 T11031 T11013 conj was,remained
R3379 T11032 T11033 det this,location
R3380 T11033 T11030 pobj location,despite
R3381 T11034 T11033 amod abnormal,location
R3382 T11035 T11033 amod rostral,location
R3383 T11036 T11031 punct ", ",was
R3384 T11037 T11031 nsubj expression,was
R3385 T11038 T11037 prep of,expression
R3386 T11039 T11040 compound parathyroid,hormone
R3387 T11040 T11038 pobj hormone,of
R3388 T11041 T11031 acomp indistinguishable,was
R3389 T11042 T11031 prep between,was
R3390 T11043 T11044 compound Alk5,mutants
R3391 T11044 T11042 pobj mutants,between
R3392 T11045 T11044 cc and,mutants
R3393 T11046 T11044 conj controls,mutants
R3394 T11047 T11031 prep at,was
R3395 T11048 T11047 pobj E14,at
R3396 T11049 T11050 punct (,F
R3397 T11050 T11031 parataxis F,was
R3398 T11051 T11050 nmod Fig.,F
R3399 T11052 T11050 nmod 8C,F
R3400 T11053 T11050 punct ",",F
R3401 T11054 T11050 punct ),F
R3402 T11055 T11013 punct .,remained
R3403 T11057 T11058 aux To,conclude
R3404 T11058 T11059 advcl conclude,were
R3405 T11060 T11059 punct ", ",were
R3406 T11061 T11062 det the,phenotypes
R3407 T11062 T11059 nsubj phenotypes,were
R3408 T11063 T11062 amod observed,phenotypes
R3409 T11064 T11065 amod pharyngeal,organ
R3410 T11065 T11062 compound organ,phenotypes
R3411 T11066 T11059 advmod also,were
R3412 T11067 T11059 prep in,were
R3413 T11068 T11069 compound striking,contrast
R3414 T11069 T11067 pobj contrast,in
R3415 T11070 T11069 prep to,contrast
R3416 T11071 T11070 pobj those,to
R3417 T11072 T11071 acl seen,those
R3418 T11073 T11072 prep in,seen
R3419 T11074 T11075 compound Tgfbr2,Cre
R3420 T11075 T11079 compound Cre,mutants
R3421 T11076 T11075 punct /,Cre
R3422 T11077 T11075 compound Wnt1,Cre
R3423 T11078 T11075 punct -,Cre
R3424 T11079 T11073 pobj mutants,in
R3425 T11080 T11081 punct [,9
R3426 T11081 T11059 parataxis 9,were
R3427 T11082 T11081 nummod 8,9
R3428 T11083 T11081 punct ",",9
R3429 T11084 T11081 punct ],9
R3430 T11085 T11059 punct .,were