craft-sa-dev Home  

PMC:1635039 / 1327-5886 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2694 11-12 DT denotes A
T2696 13-25 JJ denotes considerable
T2695 26-36 NN denotes percentage
T2698 37-39 IN denotes of
T2699 40-47 JJ denotes cardiac
T2701 48-53 NN denotes birth
T2700 54-61 NNS denotes defects
T2702 62-64 VBZ denotes is
T2697 65-71 VBN denotes caused
T2703 72-74 IN denotes by
T2704 75-76 DT denotes a
T2705 77-84 NN denotes failure
T2706 85-87 IN denotes in
T2707 88-94 JJ denotes normal
T2708 95-104 NN denotes migration
T2709 104-106 , denotes ,
T2710 106-121 NN denotes differentiation
T2711 122-124 CC denotes or
T2712 125-135 NN denotes patterning
T2713 136-138 IN denotes of
T2714 139-142 DT denotes the
T2716 143-150 JJ denotes cardiac
T2717 151-157 JJ denotes neural
T2715 158-163 NN denotes crest
T2718 164-165 -LRB- denotes (
T2719 165-168 NN denotes CNC
T2720 168-169 -RRB- denotes )
T2721 169-170 . denotes .
T2722 170-329 sentence denotes This subset of pluripotent neural crest stem cells forms in the dorsal aspect of the neural tube at the level of the mid-otic placode to the third somite [1].
T2723 171-175 DT denotes This
T2724 176-182 NN denotes subset
T2726 183-185 IN denotes of
T2727 186-197 JJ denotes pluripotent
T2729 198-204 JJ denotes neural
T2728 205-210 NN denotes crest
T2731 211-215 NN denotes stem
T2730 216-221 NNS denotes cells
T2725 222-227 VBZ denotes forms
T2732 228-230 IN denotes in
T2733 231-234 DT denotes the
T2735 235-241 JJ denotes dorsal
T2734 242-248 NN denotes aspect
T2736 249-251 IN denotes of
T2737 252-255 DT denotes the
T2739 256-262 JJ denotes neural
T2738 263-267 NN denotes tube
T2740 268-270 IN denotes at
T2741 271-274 DT denotes the
T2742 275-280 NN denotes level
T2743 281-283 IN denotes of
T2744 284-287 DT denotes the
T2746 288-296 JJ denotes mid-otic
T2745 297-304 NN denotes placode
T2747 305-307 IN denotes to
T2748 308-311 DT denotes the
T2750 312-317 JJ denotes third
T2749 318-324 NN denotes somite
T2751 325-326 -LRB- denotes [
T2752 326-327 CD denotes 1
T2753 327-328 -RRB- denotes ]
T2754 328-329 . denotes .
T2755 329-700 sentence denotes Subsequently cardiac neural crest cells (CNCCs) delaminate, undergo a phenotypic transformation from an epithelial to mesenchymal cell type, and migrate latero-ventrally into the 3rd, 4th and 6th pharyngeal arch arteries (PAAs), where they contribute to the formation of the smooth muscle cell layer of endothelial structures derived from the aortic arch arteries [1-3].
T2756 330-342 RB denotes Subsequently
T2758 343-350 JJ denotes cardiac
T2760 351-357 JJ denotes neural
T2761 358-363 NN denotes crest
T2759 364-369 NNS denotes cells
T2762 370-371 -LRB- denotes (
T2763 371-376 NNS denotes CNCCs
T2764 376-377 -RRB- denotes )
T2757 378-388 VBP denotes delaminate
T2765 388-390 , denotes ,
T2766 390-397 VBP denotes undergo
T2767 398-399 DT denotes a
T2769 400-410 JJ denotes phenotypic
T2768 411-425 NN denotes transformation
T2770 426-430 IN denotes from
T2771 431-433 DT denotes an
T2773 434-444 JJ denotes epithelial
T2774 445-447 IN denotes to
T2775 448-459 JJ denotes mesenchymal
T2776 460-464 NN denotes cell
T2772 465-469 NN denotes type
T2777 469-471 , denotes ,
T2778 471-474 CC denotes and
T2779 475-482 VBP denotes migrate
T2780 483-489 RB denotes latero
T2782 489-490 HYPH denotes -
T2781 490-499 RB denotes ventrally
T2783 500-504 IN denotes into
T2784 505-508 DT denotes the
T2786 509-512 JJ denotes 3rd
T2787 512-514 , denotes ,
T2788 514-517 JJ denotes 4th
T2789 518-521 CC denotes and
T2790 522-525 JJ denotes 6th
T2791 526-536 JJ denotes pharyngeal
T2792 537-541 NN denotes arch
T2785 542-550 NNS denotes arteries
T2793 551-552 -LRB- denotes (
T2794 552-556 NNS denotes PAAs
T2795 556-557 -RRB- denotes )
T2796 557-559 , denotes ,
T2797 559-564 WRB denotes where
T2799 565-569 PRP denotes they
T2798 570-580 VBP denotes contribute
T2800 581-583 IN denotes to
T2801 584-587 DT denotes the
T2802 588-597 NN denotes formation
T2803 598-600 IN denotes of
T2804 601-604 DT denotes the
T2806 605-611 JJ denotes smooth
T2808 612-618 NN denotes muscle
T2807 619-623 NN denotes cell
T2805 624-629 NN denotes layer
T2809 630-632 IN denotes of
T2810 633-644 JJ denotes endothelial
T2811 645-655 NNS denotes structures
T2812 656-663 VBN denotes derived
T2813 664-668 IN denotes from
T2814 669-672 DT denotes the
T2816 673-679 JJ denotes aortic
T2817 680-684 NN denotes arch
T2815 685-693 NNS denotes arteries
T2818 694-695 -LRB- denotes [
T2819 695-696 CD denotes 1
T2820 696-697 SYM denotes -
T2821 697-698 CD denotes 3
T2822 698-699 -RRB- denotes ]
T2823 699-700 . denotes .
T2824 700-879 sentence denotes A subset of CNCCs continues to migrate deeper into the aortic sac to form the aortico-pulmonary septum; a vital structure, which separates the pulmonary trunk from the aorta [4].
T2825 701-702 DT denotes A
T2826 703-709 NN denotes subset
T2828 710-712 IN denotes of
T2829 713-718 NNS denotes CNCCs
T2827 719-728 VBZ denotes continues
T2830 729-731 TO denotes to
T2831 732-739 VB denotes migrate
T2832 740-746 RBR denotes deeper
T2833 747-751 IN denotes into
T2834 752-755 DT denotes the
T2836 756-762 JJ denotes aortic
T2835 763-766 NN denotes sac
T2837 767-769 TO denotes to
T2838 770-774 VB denotes form
T2839 775-778 DT denotes the
T2841 779-786 JJ denotes aortico
T2843 786-787 HYPH denotes -
T2842 787-796 JJ denotes pulmonary
T2840 797-803 NN denotes septum
T2844 803-804 : denotes ;
T2845 805-806 DT denotes a
T2847 807-812 JJ denotes vital
T2846 813-822 NN denotes structure
T2848 822-824 , denotes ,
T2849 824-829 WDT denotes which
T2850 830-839 VBZ denotes separates
T2851 840-843 DT denotes the
T2853 844-853 JJ denotes pulmonary
T2852 854-859 NN denotes trunk
T2854 860-864 IN denotes from
T2855 865-868 DT denotes the
T2856 869-874 NN denotes aorta
T2857 875-876 -LRB- denotes [
T2858 876-877 CD denotes 4
T2859 877-878 -RRB- denotes ]
T2860 878-879 . denotes .
T2861 879-1247 sentence denotes An indispensable role of CNCCs in the development of the cardiac outflow tract was originally demonstrated by pioneering studies of Kirby and coworkers [1], who showed that ablation of the CNC in the chick led to severe outflow tract (OFT) defects including persistent truncus arteriosus (PTA), mispatterning of the great vessels and outflow tract mal-alignments [5].
T2862 880-882 DT denotes An
T2864 883-896 JJ denotes indispensable
T2863 897-901 NN denotes role
T2866 902-904 IN denotes of
T2867 905-910 NNS denotes CNCCs
T2868 911-913 IN denotes in
T2869 914-917 DT denotes the
T2870 918-929 NN denotes development
T2871 930-932 IN denotes of
T2872 933-936 DT denotes the
T2874 937-944 JJ denotes cardiac
T2875 945-952 NN denotes outflow
T2873 953-958 NN denotes tract
T2876 959-962 VBD denotes was
T2877 963-973 RB denotes originally
T2865 974-986 VBN denotes demonstrated
T2878 987-989 IN denotes by
T2879 990-1000 VBG denotes pioneering
T2880 1001-1008 NNS denotes studies
T2881 1009-1011 IN denotes of
T2882 1012-1017 NNP denotes Kirby
T2883 1018-1021 CC denotes and
T2884 1022-1031 NNS denotes coworkers
T2885 1032-1033 -LRB- denotes [
T2886 1033-1034 CD denotes 1
T2887 1034-1035 -RRB- denotes ]
T2888 1035-1037 , denotes ,
T2889 1037-1040 WP denotes who
T2890 1041-1047 VBD denotes showed
T2891 1048-1052 IN denotes that
T2893 1053-1061 NN denotes ablation
T2894 1062-1064 IN denotes of
T2895 1065-1068 DT denotes the
T2896 1069-1072 NN denotes CNC
T2897 1073-1075 IN denotes in
T2898 1076-1079 DT denotes the
T2899 1080-1085 NN denotes chick
T2892 1086-1089 VBD denotes led
T2900 1090-1092 IN denotes to
T2901 1093-1099 JJ denotes severe
T2903 1100-1107 NN denotes outflow
T2902 1108-1113 NN denotes tract
T2904 1114-1115 -LRB- denotes (
T2905 1115-1118 NN denotes OFT
T2906 1118-1119 -RRB- denotes )
T2907 1120-1127 VBZ denotes defects
T2908 1128-1137 VBG denotes including
T2909 1138-1148 JJ denotes persistent
T2911 1149-1156 NN denotes truncus
T2910 1157-1167 NN denotes arteriosus
T2912 1168-1169 -LRB- denotes (
T2913 1169-1172 NN denotes PTA
T2914 1172-1173 -RRB- denotes )
T2915 1173-1175 , denotes ,
T2916 1175-1188 VBG denotes mispatterning
T2917 1189-1191 IN denotes of
T2918 1192-1195 DT denotes the
T2920 1196-1201 JJ denotes great
T2919 1202-1209 NNS denotes vessels
T2921 1210-1213 CC denotes and
T2922 1214-1221 NN denotes outflow
T2923 1222-1227 NN denotes tract
T2924 1228-1242 NNS denotes mal-alignments
T2925 1243-1244 -LRB- denotes [
T2926 1244-1245 CD denotes 5
T2927 1245-1246 -RRB- denotes ]
T2928 1246-1247 . denotes .
T2929 1247-1446 sentence denotes Early migratory CNCCs have been shown to retain a considerable degree of plasticity and their fate is largely controlled by instructional signals from local environments into which NCCs migrate [6].
T2930 1248-1253 RB denotes Early
T2932 1254-1263 JJ denotes migratory
T2931 1264-1269 NNS denotes CNCCs
T2934 1270-1274 VBP denotes have
T2935 1275-1279 VBN denotes been
T2933 1280-1285 VBN denotes shown
T2936 1286-1288 TO denotes to
T2937 1289-1295 VB denotes retain
T2938 1296-1297 DT denotes a
T2940 1298-1310 JJ denotes considerable
T2939 1311-1317 NN denotes degree
T2941 1318-1320 IN denotes of
T2942 1321-1331 NN denotes plasticity
T2943 1332-1335 CC denotes and
T2944 1336-1341 PRP$ denotes their
T2945 1342-1346 NN denotes fate
T2947 1347-1349 VBZ denotes is
T2948 1350-1357 RB denotes largely
T2946 1358-1368 VBN denotes controlled
T2949 1369-1371 IN denotes by
T2950 1372-1385 JJ denotes instructional
T2951 1386-1393 NNS denotes signals
T2952 1394-1398 IN denotes from
T2953 1399-1404 JJ denotes local
T2954 1405-1417 NNS denotes environments
T2955 1418-1422 IN denotes into
T2957 1423-1428 WDT denotes which
T2958 1429-1433 NNS denotes NCCs
T2956 1434-1441 VBP denotes migrate
T2959 1442-1443 -LRB- denotes [
T2960 1443-1444 CD denotes 6
T2961 1444-1445 -RRB- denotes ]
T2962 1445-1446 . denotes .
T2963 1446-1601 sentence denotes Several recent studies have indicated that members of the TGF-β superfamily, i.e., TGF-βs and BMPs are likely candidates to provide some of these signals.
T2964 1447-1454 JJ denotes Several
T2966 1455-1461 JJ denotes recent
T2965 1462-1469 NNS denotes studies
T2968 1470-1474 VBP denotes have
T2967 1475-1484 VBN denotes indicated
T2969 1485-1489 IN denotes that
T2971 1490-1497 NNS denotes members
T2972 1498-1500 IN denotes of
T2973 1501-1504 DT denotes the
T2975 1505-1508 NN denotes TGF
T2977 1508-1509 HYPH denotes -
T2976 1509-1510 NN denotes β
T2974 1511-1522 NN denotes superfamily
T2978 1522-1524 , denotes ,
T2979 1524-1528 FW denotes i.e.
T2981 1528-1530 , denotes ,
T2982 1530-1533 NN denotes TGF
T2983 1533-1534 HYPH denotes -
T2980 1534-1536 NNS denotes βs
T2984 1537-1540 CC denotes and
T2985 1541-1545 NNS denotes BMPs
T2970 1546-1549 VBP denotes are
T2986 1550-1556 JJ denotes likely
T2987 1557-1567 NNS denotes candidates
T2988 1568-1570 TO denotes to
T2989 1571-1578 VB denotes provide
T2990 1579-1583 DT denotes some
T2991 1584-1586 IN denotes of
T2992 1587-1592 DT denotes these
T2993 1593-1600 NNS denotes signals
T2994 1600-1601 . denotes .
T2995 1601-1810 sentence denotes Mice deficient in TGF-β2 display fourth aortic arch artery defects [7], while neural crest cell specific abrogation of TGF-β type II receptor (Tgfbr2) results in interruption of the aortic arch and PTA [8,9].
T2996 1602-1606 NNS denotes Mice
T2998 1607-1616 JJ denotes deficient
T2999 1617-1619 IN denotes in
T3000 1620-1623 NN denotes TGF
T3002 1623-1624 HYPH denotes -
T3001 1624-1626 NN denotes β2
T2997 1627-1634 VBP denotes display
T3003 1635-1641 JJ denotes fourth
T3005 1642-1648 JJ denotes aortic
T3007 1649-1653 NN denotes arch
T3006 1654-1660 NN denotes artery
T3004 1661-1668 NNS denotes defects
T3008 1669-1670 -LRB- denotes [
T3009 1670-1671 CD denotes 7
T3010 1671-1672 -RRB- denotes ]
T3011 1672-1674 , denotes ,
T3012 1674-1679 IN denotes while
T3014 1680-1686 JJ denotes neural
T3016 1687-1692 NN denotes crest
T3015 1693-1697 NN denotes cell
T3017 1698-1706 JJ denotes specific
T3018 1707-1717 NN denotes abrogation
T3019 1718-1720 IN denotes of
T3020 1721-1724 NN denotes TGF
T3022 1724-1725 HYPH denotes -
T3021 1725-1726 NN denotes β
T3024 1727-1731 NN denotes type
T3025 1732-1734 CD denotes II
T3023 1735-1743 NN denotes receptor
T3026 1744-1745 -LRB- denotes (
T3027 1745-1751 NN denotes Tgfbr2
T3028 1751-1752 -RRB- denotes )
T3013 1753-1760 VBZ denotes results
T3029 1761-1763 IN denotes in
T3030 1764-1776 NN denotes interruption
T3031 1777-1779 IN denotes of
T3032 1780-1783 DT denotes the
T3034 1784-1790 JJ denotes aortic
T3033 1791-1795 NN denotes arch
T3035 1796-1799 CC denotes and
T3036 1800-1803 NN denotes PTA
T3037 1804-1805 -LRB- denotes [
T3039 1805-1806 CD denotes 8
T3040 1806-1807 , denotes ,
T3038 1807-1808 CD denotes 9
T3041 1808-1809 -RRB- denotes ]
T3042 1809-1810 . denotes .
T3043 1810-1986 sentence denotes BMPs 6 and -7 are required for proper formation of the outflow tract cushions [10], while BMP type II receptor is needed for proper development of the conotruncal ridges [11].
T3044 1811-1815 NNS denotes BMPs
T3045 1816-1817 CD denotes 6
T3047 1818-1821 CC denotes and
T3048 1822-1823 HYPH denotes -
T3049 1823-1824 CD denotes 7
T3050 1825-1828 VBP denotes are
T3046 1829-1837 VBN denotes required
T3051 1838-1841 IN denotes for
T3052 1842-1848 JJ denotes proper
T3053 1849-1858 NN denotes formation
T3054 1859-1861 IN denotes of
T3055 1862-1865 DT denotes the
T3057 1866-1873 NN denotes outflow
T3058 1874-1879 NN denotes tract
T3056 1880-1888 NNS denotes cushions
T3059 1889-1890 -LRB- denotes [
T3060 1890-1892 CD denotes 10
T3061 1892-1893 -RRB- denotes ]
T3062 1893-1895 , denotes ,
T3063 1895-1900 IN denotes while
T3065 1901-1904 NN denotes BMP
T3067 1905-1909 NN denotes type
T3068 1910-1912 CD denotes II
T3066 1913-1921 NN denotes receptor
T3069 1922-1924 VBZ denotes is
T3064 1925-1931 VBN denotes needed
T3070 1932-1935 IN denotes for
T3071 1936-1942 JJ denotes proper
T3072 1943-1954 NN denotes development
T3073 1955-1957 IN denotes of
T3074 1958-1961 DT denotes the
T3076 1962-1973 JJ denotes conotruncal
T3075 1974-1980 NNS denotes ridges
T3077 1981-1982 -LRB- denotes [
T3078 1982-1984 CD denotes 11
T3079 1984-1985 -RRB- denotes ]
T3080 1985-1986 . denotes .
T3081 1986-2171 sentence denotes Moreover, neural crest-specific deletion of the BMP type I receptors Alk2 and Alk3 has been shown to lead to defective aortico-pulmonary septation, among other cardiac defects [12,13].
T3082 1987-1995 RB denotes Moreover
T3084 1995-1997 , denotes ,
T3085 1997-2003 JJ denotes neural
T3086 2004-2009 NN denotes crest
T3088 2009-2010 HYPH denotes -
T3087 2010-2018 JJ denotes specific
T3089 2019-2027 NN denotes deletion
T3090 2028-2030 IN denotes of
T3091 2031-2034 DT denotes the
T3093 2035-2038 NN denotes BMP
T3094 2039-2043 NN denotes type
T3095 2044-2045 CD denotes I
T3096 2046-2055 NNS denotes receptors
T3092 2056-2060 NN denotes Alk2
T3097 2061-2064 CC denotes and
T3098 2065-2069 NN denotes Alk3
T3099 2070-2073 VBZ denotes has
T3100 2074-2078 VBN denotes been
T3083 2079-2084 VBN denotes shown
T3101 2085-2087 TO denotes to
T3102 2088-2092 VB denotes lead
T3103 2093-2095 IN denotes to
T3104 2096-2105 JJ denotes defective
T3106 2106-2113 JJ denotes aortico
T3108 2113-2114 HYPH denotes -
T3107 2114-2123 JJ denotes pulmonary
T3105 2124-2133 NN denotes septation
T3109 2133-2135 , denotes ,
T3110 2135-2140 IN denotes among
T3111 2141-2146 JJ denotes other
T3113 2147-2154 JJ denotes cardiac
T3112 2155-2162 NNS denotes defects
T3114 2163-2164 -LRB- denotes [
T3116 2164-2166 CD denotes 12
T3117 2166-2167 , denotes ,
T3115 2167-2169 CD denotes 13
T3118 2169-2170 -RRB- denotes ]
T3119 2170-2171 . denotes .
T3120 2171-2293 sentence denotes TGF-β subfamily ligands signal via a receptor complex composed of two type II receptors and two type I receptors [14,15].
T3121 2172-2175 NN denotes TGF
T3123 2175-2176 HYPH denotes -
T3122 2176-2177 NN denotes β
T3125 2178-2187 NN denotes subfamily
T3124 2188-2195 NNS denotes ligands
T3126 2196-2202 VBP denotes signal
T3127 2203-2206 IN denotes via
T3128 2207-2208 DT denotes a
T3130 2209-2217 NN denotes receptor
T3129 2218-2225 NN denotes complex
T3131 2226-2234 VBN denotes composed
T3132 2235-2237 IN denotes of
T3133 2238-2241 CD denotes two
T3135 2242-2246 NN denotes type
T3136 2247-2249 CD denotes II
T3134 2250-2259 NNS denotes receptors
T3137 2260-2263 CC denotes and
T3138 2264-2267 CD denotes two
T3140 2268-2272 NN denotes type
T3141 2273-2274 CD denotes I
T3139 2275-2284 NNS denotes receptors
T3142 2285-2286 -LRB- denotes [
T3144 2286-2288 CD denotes 14
T3145 2288-2289 , denotes ,
T3143 2289-2291 CD denotes 15
T3146 2291-2292 -RRB- denotes ]
T3147 2292-2293 . denotes .
T3148 2293-2475 sentence denotes Ligand binding leads to phosphorylation and activation of type I receptors, which, in turn, phosphorylate and activate a specific set of downstream signaling molecules called Smads.
T3149 2294-2300 NN denotes Ligand
T3150 2301-2308 NN denotes binding
T3151 2309-2314 VBZ denotes leads
T3152 2315-2317 IN denotes to
T3153 2318-2333 NN denotes phosphorylation
T3154 2334-2337 CC denotes and
T3155 2338-2348 NN denotes activation
T3156 2349-2351 IN denotes of
T3157 2352-2356 NN denotes type
T3159 2357-2358 CD denotes I
T3158 2359-2368 NNS denotes receptors
T3160 2368-2370 , denotes ,
T3161 2370-2375 WDT denotes which
T3163 2375-2377 , denotes ,
T3164 2377-2379 IN denotes in
T3165 2380-2384 NN denotes turn
T3166 2384-2386 , denotes ,
T3162 2386-2399 VBP denotes phosphorylate
T3167 2400-2403 CC denotes and
T3168 2404-2412 VBP denotes activate
T3169 2413-2414 DT denotes a
T3171 2415-2423 JJ denotes specific
T3170 2424-2427 NN denotes set
T3172 2428-2430 IN denotes of
T3173 2431-2441 JJ denotes downstream
T3175 2442-2451 NN denotes signaling
T3174 2452-2461 NNS denotes molecules
T3176 2462-2468 VBN denotes called
T3177 2469-2474 NNS denotes Smads
T3178 2474-2475 . denotes .
T3179 2475-2728 sentence denotes In general terms, TGF-βs bind to the TGF-β type II receptor (TGFβRII) and TGF-β type I receptor (ALK5) activating TGF-β Smads (2 and 3), while BMPs bind to the BMP type II receptor and type I receptors ALK2, -3, or 6, activating BMP Smads (1, 5 and 8).
T3180 2476-2478 IN denotes In
T3182 2479-2486 JJ denotes general
T3183 2487-2492 NNS denotes terms
T3184 2492-2494 , denotes ,
T3185 2494-2497 NN denotes TGF
T3187 2497-2498 HYPH denotes -
T3186 2498-2500 NNS denotes βs
T3181 2501-2505 VBP denotes bind
T3188 2506-2508 IN denotes to
T3189 2509-2512 DT denotes the
T3191 2513-2516 NN denotes TGF
T3193 2516-2517 HYPH denotes -
T3192 2517-2518 NN denotes β
T3194 2519-2523 NN denotes type
T3195 2524-2526 CD denotes II
T3190 2527-2535 NN denotes receptor
T3196 2536-2537 -LRB- denotes (
T3197 2537-2544 NN denotes TGFβRII
T3198 2544-2545 -RRB- denotes )
T3199 2546-2549 CC denotes and
T3200 2550-2553 NN denotes TGF
T3202 2553-2554 HYPH denotes -
T3201 2554-2555 NN denotes β
T3204 2556-2560 NN denotes type
T3205 2561-2562 CD denotes I
T3203 2563-2571 NN denotes receptor
T3206 2572-2573 -LRB- denotes (
T3207 2573-2577 NN denotes ALK5
T3208 2577-2578 -RRB- denotes )
T3209 2579-2589 VBG denotes activating
T3210 2590-2593 NN denotes TGF
T3212 2593-2594 HYPH denotes -
T3211 2594-2595 NN denotes β
T3213 2596-2601 NNS denotes Smads
T3214 2602-2603 -LRB- denotes (
T3215 2603-2604 CD denotes 2
T3216 2605-2608 CC denotes and
T3217 2609-2610 CD denotes 3
T3218 2610-2611 -RRB- denotes )
T3219 2611-2613 , denotes ,
T3220 2613-2618 IN denotes while
T3222 2619-2623 NNS denotes BMPs
T3221 2624-2628 VBP denotes bind
T3223 2629-2631 IN denotes to
T3224 2632-2635 DT denotes the
T3226 2636-2639 NN denotes BMP
T3227 2640-2644 NN denotes type
T3229 2645-2647 CD denotes II
T3228 2648-2656 NN denotes receptor
T3230 2657-2660 CC denotes and
T3231 2661-2665 NN denotes type
T3233 2666-2667 CD denotes I
T3232 2668-2677 NNS denotes receptors
T3225 2678-2682 NN denotes ALK2
T3234 2682-2684 , denotes ,
T3235 2684-2685 SYM denotes -
T3236 2685-2686 CD denotes 3
T3237 2686-2688 , denotes ,
T3238 2688-2690 CC denotes or
T3239 2691-2692 CD denotes 6
T3240 2692-2694 , denotes ,
T3241 2694-2704 VBG denotes activating
T3242 2705-2708 NN denotes BMP
T3243 2709-2714 NNS denotes Smads
T3244 2715-2716 -LRB- denotes (
T3245 2716-2717 CD denotes 1
T3246 2717-2719 , denotes ,
T3247 2719-2720 CD denotes 5
T3248 2721-2724 CC denotes and
T3249 2725-2726 CD denotes 8
T3250 2726-2727 -RRB- denotes )
T3251 2727-2728 . denotes .
T3252 2728-2925 sentence denotes However, it is likely that these signaling interactions are more complex in vivo, possibly allowing formation of heterotetrameric complexes composed of different type II and type I receptors [16].
T3253 2729-2736 RB denotes However
T3255 2736-2738 , denotes ,
T3256 2738-2740 PRP denotes it
T3254 2741-2743 VBZ denotes is
T3257 2744-2750 JJ denotes likely
T3258 2751-2755 IN denotes that
T3260 2756-2761 DT denotes these
T3262 2762-2771 NN denotes signaling
T3261 2772-2784 NNS denotes interactions
T3259 2785-2788 VBP denotes are
T3263 2789-2793 RBR denotes more
T3264 2794-2801 JJ denotes complex
T3265 2802-2804 FW denotes in
T3266 2805-2809 FW denotes vivo
T3267 2809-2811 , denotes ,
T3268 2811-2819 RB denotes possibly
T3269 2820-2828 VBG denotes allowing
T3270 2829-2838 NN denotes formation
T3271 2839-2841 IN denotes of
T3272 2842-2858 JJ denotes heterotetrameric
T3273 2859-2868 NNS denotes complexes
T3274 2869-2877 VBN denotes composed
T3275 2878-2880 IN denotes of
T3276 2881-2890 JJ denotes different
T3278 2891-2895 NN denotes type
T3279 2896-2898 CD denotes II
T3280 2899-2902 CC denotes and
T3281 2903-2907 NN denotes type
T3282 2908-2909 CD denotes I
T3277 2910-2919 NNS denotes receptors
T3283 2920-2921 -LRB- denotes [
T3284 2921-2923 CD denotes 16
T3285 2923-2924 -RRB- denotes ]
T3286 2924-2925 . denotes .
T3287 2925-3060 sentence denotes In addition, recent studies have identified novel TGF-β-related ligands, which can bind to entire different combinations of receptors.
T3288 2926-2928 IN denotes In
T3290 2929-2937 NN denotes addition
T3291 2937-2939 , denotes ,
T3292 2939-2945 JJ denotes recent
T3293 2946-2953 NNS denotes studies
T3294 2954-2958 VBP denotes have
T3289 2959-2969 VBN denotes identified
T3295 2970-2975 JJ denotes novel
T3297 2976-2979 NN denotes TGF
T3299 2979-2980 HYPH denotes -
T3298 2980-2981 NN denotes β
T3301 2981-2982 HYPH denotes -
T3300 2982-2989 VBN denotes related
T3296 2990-2997 NNS denotes ligands
T3302 2997-2999 , denotes ,
T3303 2999-3004 WDT denotes which
T3305 3005-3008 MD denotes can
T3304 3009-3013 VB denotes bind
T3306 3014-3016 IN denotes to
T3307 3017-3023 JJ denotes entire
T3309 3024-3033 JJ denotes different
T3308 3034-3046 NNS denotes combinations
T3310 3047-3049 IN denotes of
T3311 3050-3059 NNS denotes receptors
T3312 3059-3060 . denotes .
T3313 3060-3203 sentence denotes For instance, growth and differentiation factors (GDFs) 8 and 9 can bind to Activin type II receptor and ALK5 to activate TGF-β Smads [17,18].
T3314 3061-3064 IN denotes For
T3316 3065-3073 NN denotes instance
T3317 3073-3075 , denotes ,
T3318 3075-3081 NN denotes growth
T3320 3082-3085 CC denotes and
T3321 3086-3101 NN denotes differentiation
T3319 3102-3109 NNS denotes factors
T3322 3110-3111 -LRB- denotes (
T3323 3111-3115 NNS denotes GDFs
T3324 3115-3116 -RRB- denotes )
T3325 3117-3118 CD denotes 8
T3326 3119-3122 CC denotes and
T3327 3123-3124 CD denotes 9
T3328 3125-3128 MD denotes can
T3315 3129-3133 VB denotes bind
T3329 3134-3136 IN denotes to
T3330 3137-3144 NN denotes Activin
T3332 3145-3149 NN denotes type
T3333 3150-3152 CD denotes II
T3331 3153-3161 NN denotes receptor
T3334 3162-3165 CC denotes and
T3335 3166-3170 NN denotes ALK5
T3336 3171-3173 TO denotes to
T3337 3174-3182 VB denotes activate
T3338 3183-3186 NN denotes TGF
T3340 3186-3187 HYPH denotes -
T3339 3187-3188 NN denotes β
T3341 3189-3194 NNS denotes Smads
T3342 3195-3196 -LRB- denotes [
T3344 3196-3198 CD denotes 17
T3345 3198-3199 , denotes ,
T3343 3199-3201 CD denotes 18
T3346 3201-3202 -RRB- denotes ]
T3347 3202-3203 . denotes .
T3348 3203-3363 sentence denotes Therefore, we hypothesized that deletion of Alk5 in a specific cell lineage should reveal phenotypes which cannot be seen in comparable mutants lacking Tgfbr2.
T3349 3204-3213 RB denotes Therefore
T3351 3213-3215 , denotes ,
T3352 3215-3217 PRP denotes we
T3350 3218-3230 VBD denotes hypothesized
T3353 3231-3235 IN denotes that
T3355 3236-3244 NN denotes deletion
T3356 3245-3247 IN denotes of
T3357 3248-3252 NN denotes Alk5
T3358 3253-3255 IN denotes in
T3359 3256-3257 DT denotes a
T3361 3258-3266 JJ denotes specific
T3362 3267-3271 NN denotes cell
T3360 3272-3279 NN denotes lineage
T3363 3280-3286 MD denotes should
T3354 3287-3293 VB denotes reveal
T3364 3294-3304 NNS denotes phenotypes
T3365 3305-3310 WDT denotes which
T3367 3311-3314 MD denotes can
T3368 3314-3317 RB denotes not
T3369 3318-3320 VB denotes be
T3366 3321-3325 VBN denotes seen
T3370 3326-3328 IN denotes in
T3371 3329-3339 JJ denotes comparable
T3372 3340-3347 NNS denotes mutants
T3373 3348-3355 VBG denotes lacking
T3374 3356-3362 NN denotes Tgfbr2
T3375 3362-3363 . denotes .
T3376 3363-3626 sentence denotes Indeed, we recently showed that neural crest cell specific Alk5 mutants display a unique spectrum of craniofacial developmental defects, e.g., cleft snout and severe mandibular hypoplasia [19]; these phenotypes were not seen in corresponding Tgfbr2 mutants [20].
T3377 3364-3370 RB denotes Indeed
T3379 3370-3372 , denotes ,
T3380 3372-3374 PRP denotes we
T3381 3375-3383 RB denotes recently
T3378 3384-3390 VBD denotes showed
T3383 3391-3395 IN denotes that
T3385 3396-3402 JJ denotes neural
T3387 3403-3408 NN denotes crest
T3386 3409-3413 NN denotes cell
T3388 3414-3422 JJ denotes specific
T3390 3423-3427 NN denotes Alk5
T3389 3428-3435 NNS denotes mutants
T3384 3436-3443 VBP denotes display
T3391 3444-3445 DT denotes a
T3393 3446-3452 JJ denotes unique
T3392 3453-3461 NN denotes spectrum
T3394 3462-3464 IN denotes of
T3395 3465-3477 JJ denotes craniofacial
T3397 3478-3491 JJ denotes developmental
T3396 3492-3499 NNS denotes defects
T3398 3499-3501 , denotes ,
T3399 3501-3505 FW denotes e.g.
T3401 3505-3507 , denotes ,
T3402 3507-3512 NN denotes cleft
T3400 3513-3518 NN denotes snout
T3403 3519-3522 CC denotes and
T3404 3523-3529 JJ denotes severe
T3406 3530-3540 JJ denotes mandibular
T3405 3541-3551 NN denotes hypoplasia
T3407 3552-3553 -LRB- denotes [
T3408 3553-3555 CD denotes 19
T3409 3555-3556 -RRB- denotes ]
T3410 3556-3557 : denotes ;
T3411 3558-3563 DT denotes these
T3412 3564-3574 NNS denotes phenotypes
T3413 3575-3579 VBD denotes were
T3414 3580-3583 RB denotes not
T3382 3584-3588 VBN denotes seen
T3415 3589-3591 IN denotes in
T3416 3592-3605 VBG denotes corresponding
T3418 3606-3612 NN denotes Tgfbr2
T3417 3613-3620 NNS denotes mutants
T3419 3621-3622 -LRB- denotes [
T3420 3622-3624 CD denotes 20
T3421 3624-3625 -RRB- denotes ]
T3422 3625-3626 . denotes .
T3423 3626-3855 sentence denotes To determine, whether ALK5 would also mediate unique non-redundant signaling events in cardiac neural crest cells, we focused on cardiac and pharyngeal phenotypes of mouse embryos lacking Alk5 specifically in neural crest cells.
T3424 3627-3629 TO denotes To
T3425 3630-3639 VB denotes determine
T3427 3639-3641 , denotes ,
T3428 3641-3648 IN denotes whether
T3430 3649-3653 NN denotes ALK5
T3431 3654-3659 MD denotes would
T3432 3660-3664 RB denotes also
T3429 3665-3672 VB denotes mediate
T3433 3673-3679 JJ denotes unique
T3435 3680-3693 JJ denotes non-redundant
T3436 3694-3703 NN denotes signaling
T3434 3704-3710 NNS denotes events
T3437 3711-3713 IN denotes in
T3438 3714-3721 JJ denotes cardiac
T3440 3722-3728 JJ denotes neural
T3439 3729-3734 NN denotes crest
T3441 3735-3740 NNS denotes cells
T3442 3740-3742 , denotes ,
T3443 3742-3744 PRP denotes we
T3426 3745-3752 VBD denotes focused
T3444 3753-3755 IN denotes on
T3445 3756-3763 JJ denotes cardiac
T3447 3764-3767 CC denotes and
T3448 3768-3778 JJ denotes pharyngeal
T3446 3779-3789 NNS denotes phenotypes
T3449 3790-3792 IN denotes of
T3450 3793-3798 NN denotes mouse
T3451 3799-3806 NNS denotes embryos
T3452 3807-3814 VBG denotes lacking
T3453 3815-3819 NN denotes Alk5
T3454 3820-3832 RB denotes specifically
T3455 3833-3835 IN denotes in
T3456 3836-3842 JJ denotes neural
T3458 3843-3848 NN denotes crest
T3457 3849-3854 NNS denotes cells
T3459 3854-3855 . denotes .
T3460 3855-3974 sentence denotes We discovered that in Alk5/Wnt1-Cre mutants, pharyngeal organs (thymus and parathyroid) fail to migrate appropriately.
T3461 3856-3858 PRP denotes We
T3462 3859-3869 VBD denotes discovered
T3463 3870-3874 IN denotes that
T3465 3875-3877 IN denotes in
T3466 3878-3882 NN denotes Alk5
T3468 3882-3883 HYPH denotes /
T3469 3883-3887 NN denotes Wnt1
T3470 3887-3888 HYPH denotes -
T3467 3888-3891 NN denotes Cre
T3471 3892-3899 NNS denotes mutants
T3472 3899-3901 , denotes ,
T3473 3901-3911 JJ denotes pharyngeal
T3474 3912-3918 NNS denotes organs
T3475 3919-3920 -LRB- denotes (
T3476 3920-3926 NN denotes thymus
T3477 3927-3930 CC denotes and
T3478 3931-3942 NN denotes parathyroid
T3479 3942-3943 -RRB- denotes )
T3464 3944-3948 VBP denotes fail
T3480 3949-3951 TO denotes to
T3481 3952-3959 VB denotes migrate
T3482 3960-3973 RB denotes appropriately
T3483 3973-3974 . denotes .
T3484 3974-4120 sentence denotes Moreover, the mutant embryos display severe aortic sac and pharyngeal arch artery defects, and failed aortico-pulmonary septation leading to PTA.
T3485 3975-3983 RB denotes Moreover
T3487 3983-3985 , denotes ,
T3488 3985-3988 DT denotes the
T3490 3989-3995 NN denotes mutant
T3489 3996-4003 NNS denotes embryos
T3486 4004-4011 VBP denotes display
T3491 4012-4018 JJ denotes severe
T3493 4019-4025 JJ denotes aortic
T3492 4026-4029 NN denotes sac
T3495 4030-4033 CC denotes and
T3496 4034-4044 JJ denotes pharyngeal
T3498 4045-4049 NN denotes arch
T3497 4050-4056 NN denotes artery
T3494 4057-4064 NNS denotes defects
T3499 4064-4066 , denotes ,
T3500 4066-4069 CC denotes and
T3501 4070-4076 VBD denotes failed
T3502 4077-4084 JJ denotes aortico
T3504 4084-4085 HYPH denotes -
T3503 4085-4094 JJ denotes pulmonary
T3505 4095-4104 NN denotes septation
T3506 4105-4112 VBG denotes leading
T3507 4113-4115 IN denotes to
T3508 4116-4119 NN denotes PTA
T3509 4119-4120 . denotes .
T3510 4120-4292 sentence denotes Our data further suggest that at least some of these abnormal detected phenotypes result from a dramatic increase in apoptosis of postmigratory cardiac neural crest cells.
T3511 4121-4124 PRP$ denotes Our
T3512 4125-4129 NNS denotes data
T3514 4130-4137 RB denotes further
T3513 4138-4145 VBP denotes suggest
T3515 4146-4150 IN denotes that
T3517 4151-4153 RB denotes at
T3518 4154-4159 RBS denotes least
T3519 4160-4164 DT denotes some
T3520 4165-4167 IN denotes of
T3521 4168-4173 DT denotes these
T3523 4174-4182 JJ denotes abnormal
T3524 4183-4191 VBN denotes detected
T3522 4192-4202 NNS denotes phenotypes
T3516 4203-4209 VBP denotes result
T3525 4210-4214 IN denotes from
T3526 4215-4216 DT denotes a
T3528 4217-4225 JJ denotes dramatic
T3527 4226-4234 NN denotes increase
T3529 4235-4237 IN denotes in
T3530 4238-4247 NN denotes apoptosis
T3531 4248-4250 IN denotes of
T3532 4251-4264 JJ denotes postmigratory
T3534 4265-4272 JJ denotes cardiac
T3536 4273-4279 JJ denotes neural
T3535 4280-4285 NN denotes crest
T3533 4286-4291 NNS denotes cells
T3537 4291-4292 . denotes .
T3538 4292-4559 sentence denotes These phenotypes differ remarkably from those seen in corresponding Tgfbr2 mutants, suggesting that ALK5 mediates a wider spectrum of signaling events than its classical binding partner TGFβRII in cardiac neural crest cells during cardiac and pharyngeal development.
T3539 4293-4298 DT denotes These
T3540 4299-4309 NNS denotes phenotypes
T3541 4310-4316 VBP denotes differ
T3542 4317-4327 RB denotes remarkably
T3543 4328-4332 IN denotes from
T3544 4333-4338 DT denotes those
T3545 4339-4343 VBN denotes seen
T3546 4344-4346 IN denotes in
T3547 4347-4360 VBG denotes corresponding
T3549 4361-4367 NN denotes Tgfbr2
T3548 4368-4375 NNS denotes mutants
T3550 4375-4377 , denotes ,
T3551 4377-4387 VBG denotes suggesting
T3552 4388-4392 IN denotes that
T3554 4393-4397 NN denotes ALK5
T3553 4398-4406 VBZ denotes mediates
T3555 4407-4408 DT denotes a
T3557 4409-4414 JJR denotes wider
T3556 4415-4423 NN denotes spectrum
T3558 4424-4426 IN denotes of
T3559 4427-4436 NN denotes signaling
T3560 4437-4443 NNS denotes events
T3561 4444-4448 IN denotes than
T3562 4449-4452 PRP$ denotes its
T3564 4453-4462 JJ denotes classical
T3565 4463-4470 NN denotes binding
T3563 4471-4478 NN denotes partner
T3566 4479-4486 NN denotes TGFβRII
T3567 4487-4489 IN denotes in
T3568 4490-4497 JJ denotes cardiac
T3570 4498-4504 JJ denotes neural
T3571 4505-4510 NN denotes crest
T3569 4511-4516 NNS denotes cells
T3572 4517-4523 IN denotes during
T3573 4524-4531 JJ denotes cardiac
T3575 4532-4535 CC denotes and
T3576 4536-4546 JJ denotes pharyngeal
T3574 4547-4558 NN denotes development
T3577 4558-4559 . denotes .
R1000 T3489 T3486 nsubj embryos,display
R1001 T3490 T3489 compound mutant,embryos
R1002 T3491 T3492 amod severe,sac
R1003 T3492 T3494 nmod sac,defects
R1004 T3493 T3492 amod aortic,sac
R1005 T3494 T3486 dobj defects,display
R1006 T3495 T3492 cc and,sac
R1007 T3496 T3497 amod pharyngeal,artery
R1008 T3497 T3492 conj artery,sac
R1009 T3498 T3497 compound arch,artery
R1010 T3499 T3486 punct ", ",display
R1011 T3500 T3486 cc and,display
R1012 T3501 T3486 conj failed,display
R1013 T3502 T3503 amod aortico,pulmonary
R1014 T3503 T3505 amod pulmonary,septation
R1015 T3504 T3503 punct -,pulmonary
R1016 T3505 T3501 dobj septation,failed
R1017 T3506 T3505 acl leading,septation
R1018 T3507 T3506 prep to,leading
R1019 T3508 T3507 pobj PTA,to
R1020 T3509 T3486 punct .,display
R1021 T3511 T3512 poss Our,data
R1022 T3512 T3513 nsubj data,suggest
R1023 T3514 T3513 advmod further,suggest
R1024 T3515 T3516 mark that,result
R1025 T3516 T3513 ccomp result,suggest
R1026 T3517 T3518 advmod at,least
R1027 T3518 T3519 advmod least,some
R1028 T3519 T3516 nsubj some,result
R1029 T3520 T3519 prep of,some
R1030 T3521 T3522 det these,phenotypes
R1031 T3522 T3520 pobj phenotypes,of
R1032 T3523 T3522 amod abnormal,phenotypes
R1033 T3524 T3522 amod detected,phenotypes
R1034 T3525 T3516 prep from,result
R1035 T3526 T3527 det a,increase
R1036 T3527 T3525 pobj increase,from
R1037 T3528 T3527 amod dramatic,increase
R1038 T3529 T3527 prep in,increase
R1039 T3530 T3529 pobj apoptosis,in
R1040 T3531 T3530 prep of,apoptosis
R1041 T3532 T3533 amod postmigratory,cells
R1042 T3533 T3531 pobj cells,of
R1043 T3534 T3535 amod cardiac,crest
R1044 T3535 T3533 compound crest,cells
R1045 T3536 T3535 amod neural,crest
R1046 T3537 T3513 punct .,suggest
R1047 T3539 T3540 det These,phenotypes
R1048 T3540 T3541 nsubj phenotypes,differ
R1049 T3542 T3541 advmod remarkably,differ
R1050 T3543 T3541 prep from,differ
R1051 T3544 T3543 pobj those,from
R1052 T3545 T3544 acl seen,those
R1053 T3546 T3545 prep in,seen
R1054 T3547 T3548 amod corresponding,mutants
R1055 T3548 T3546 pobj mutants,in
R1056 T3549 T3548 compound Tgfbr2,mutants
R1057 T3550 T3545 punct ", ",seen
R1058 T3551 T3545 advcl suggesting,seen
R1059 T3552 T3553 mark that,mediates
R1060 T3553 T3551 ccomp mediates,suggesting
R1061 T3554 T3553 nsubj ALK5,mediates
R1062 T3555 T3556 det a,spectrum
R1063 T3556 T3553 dobj spectrum,mediates
R1064 T3557 T3556 amod wider,spectrum
R1065 T3558 T3556 prep of,spectrum
R1066 T3559 T3560 compound signaling,events
R1067 T3560 T3558 pobj events,of
R1068 T3561 T3556 prep than,spectrum
R1069 T3562 T3563 poss its,partner
R1070 T3563 T3561 pobj partner,than
R1071 T3564 T3563 amod classical,partner
R1072 T3565 T3563 compound binding,partner
R1073 T3566 T3563 appos TGFβRII,partner
R1074 T3567 T3553 prep in,mediates
R1075 T3568 T3569 amod cardiac,cells
R1076 T3569 T3567 pobj cells,in
R1077 T3570 T3569 amod neural,cells
R1078 T3571 T3569 compound crest,cells
R1079 T3572 T3553 prep during,mediates
R1080 T3573 T3574 amod cardiac,development
R1081 T3574 T3572 pobj development,during
R1082 T3575 T3573 cc and,cardiac
R1083 T3576 T3573 conj pharyngeal,cardiac
R245 T2694 T2695 det A,percentage
R246 T2695 T2697 nsubjpass percentage,caused
R247 T2696 T2695 amod considerable,percentage
R248 T2698 T2695 prep of,percentage
R249 T2699 T2700 amod cardiac,defects
R250 T2700 T2698 pobj defects,of
R251 T2701 T2700 compound birth,defects
R252 T2702 T2697 auxpass is,caused
R253 T2703 T2697 agent by,caused
R254 T2704 T2705 det a,failure
R255 T2705 T2703 pobj failure,by
R256 T2706 T2705 prep in,failure
R257 T2707 T2708 amod normal,migration
R258 T2708 T2706 pobj migration,in
R259 T2709 T2708 punct ", ",migration
R260 T2710 T2708 conj differentiation,migration
R261 T2711 T2710 cc or,differentiation
R262 T2712 T2710 conj patterning,differentiation
R263 T2713 T2708 prep of,migration
R264 T2714 T2715 det the,crest
R265 T2715 T2713 pobj crest,of
R266 T2716 T2715 amod cardiac,crest
R267 T2717 T2715 amod neural,crest
R268 T2718 T2715 punct (,crest
R269 T2719 T2715 appos CNC,crest
R270 T2720 T2697 punct ),caused
R271 T2721 T2697 punct .,caused
R272 T2723 T2724 det This,subset
R273 T2724 T2725 nsubj subset,forms
R274 T2726 T2724 prep of,subset
R275 T2727 T2728 amod pluripotent,crest
R276 T2728 T2730 compound crest,cells
R277 T2729 T2728 amod neural,crest
R278 T2730 T2726 pobj cells,of
R279 T2837 T2838 aux to,form
R280 T2838 T2831 advcl form,migrate
R281 T2839 T2840 det the,septum
R282 T2731 T2730 compound stem,cells
R283 T2840 T2838 dobj septum,form
R284 T2841 T2842 amod aortico,pulmonary
R285 T2732 T2725 prep in,forms
R286 T2733 T2734 det the,aspect
R287 T2842 T2840 amod pulmonary,septum
R288 T2734 T2732 pobj aspect,in
R289 T2735 T2734 amod dorsal,aspect
R290 T2843 T2842 punct -,pulmonary
R291 T2736 T2734 prep of,aspect
R292 T2737 T2738 det the,tube
R293 T2738 T2736 pobj tube,of
R294 T2844 T2840 punct ;,septum
R295 T2739 T2738 amod neural,tube
R296 T2740 T2725 prep at,forms
R297 T2741 T2742 det the,level
R298 T2845 T2846 det a,structure
R299 T2742 T2740 pobj level,at
R300 T2743 T2742 prep of,level
R301 T2846 T2840 appos structure,septum
R302 T2744 T2745 det the,placode
R303 T2745 T2743 pobj placode,of
R304 T2746 T2745 amod mid-otic,placode
R305 T2847 T2846 amod vital,structure
R306 T2747 T2742 prep to,level
R307 T2748 T2749 det the,somite
R308 T2749 T2747 pobj somite,to
R309 T2848 T2846 punct ", ",structure
R310 T2750 T2749 amod third,somite
R311 T2751 T2752 punct [,1
R312 T2752 T2725 parataxis 1,forms
R313 T2753 T2752 punct ],1
R314 T2754 T2725 punct .,forms
R315 T2849 T2850 dep which,separates
R316 T2756 T2757 advmod Subsequently,delaminate
R317 T2758 T2759 amod cardiac,cells
R318 T2850 T2846 relcl separates,structure
R319 T2759 T2757 nsubj cells,delaminate
R320 T2760 T2761 amod neural,crest
R321 T2761 T2759 compound crest,cells
R322 T2851 T2852 det the,trunk
R323 T2762 T2759 punct (,cells
R324 T2852 T2850 dobj trunk,separates
R325 T2763 T2759 appos CNCCs,cells
R326 T2764 T2757 punct ),delaminate
R327 T2765 T2757 punct ", ",delaminate
R328 T2766 T2757 conj undergo,delaminate
R329 T2853 T2852 amod pulmonary,trunk
R330 T2767 T2768 det a,transformation
R331 T2768 T2766 dobj transformation,undergo
R332 T2769 T2768 amod phenotypic,transformation
R333 T2854 T2850 prep from,separates
R334 T2770 T2766 prep from,undergo
R335 T2771 T2772 det an,type
R336 T2855 T2856 det the,aorta
R337 T2772 T2770 pobj type,from
R338 T2773 T2772 amod epithelial,type
R339 T2774 T2773 prep to,epithelial
R340 T2856 T2854 pobj aorta,from
R341 T2775 T2774 amod mesenchymal,to
R342 T2776 T2772 compound cell,type
R343 T2857 T2858 punct [,4
R344 T2777 T2766 punct ", ",undergo
R345 T2778 T2766 cc and,undergo
R346 T2779 T2766 conj migrate,undergo
R347 T2858 T2850 parataxis 4,separates
R348 T2780 T2781 advmod latero,ventrally
R349 T2781 T2779 advmod ventrally,migrate
R350 T2782 T2781 punct -,ventrally
R351 T2783 T2779 prep into,migrate
R352 T2859 T2858 punct ],4
R353 T2784 T2785 det the,arteries
R354 T2860 T2827 punct .,continues
R355 T2785 T2783 pobj arteries,into
R356 T2862 T2863 det An,role
R357 T2786 T2785 amod 3rd,arteries
R358 T2787 T2786 punct ", ",3rd
R359 T2788 T2786 conj 4th,3rd
R360 T2863 T2865 nsubjpass role,demonstrated
R361 T2789 T2788 cc and,4th
R362 T2790 T2788 conj 6th,4th
R363 T2791 T2785 amod pharyngeal,arteries
R364 T2792 T2785 compound arch,arteries
R365 T2793 T2785 punct (,arteries
R366 T2794 T2785 appos PAAs,arteries
R367 T2795 T2785 punct ),arteries
R368 T2864 T2863 amod indispensable,role
R369 T2796 T2785 punct ", ",arteries
R370 T2797 T2798 advmod where,contribute
R371 T2798 T2785 relcl contribute,arteries
R372 T2866 T2863 prep of,role
R373 T2799 T2798 nsubj they,contribute
R374 T2800 T2798 prep to,contribute
R375 T2801 T2802 det the,formation
R376 T2867 T2866 pobj CNCCs,of
R377 T2802 T2800 pobj formation,to
R378 T2803 T2802 prep of,formation
R379 T2868 T2863 prep in,role
R380 T2804 T2805 det the,layer
R381 T2805 T2803 pobj layer,of
R382 T2806 T2807 amod smooth,cell
R383 T2869 T2870 det the,development
R384 T2807 T2805 compound cell,layer
R385 T2808 T2807 compound muscle,cell
R386 T2809 T2805 prep of,layer
R387 T2870 T2868 pobj development,in
R388 T2810 T2811 amod endothelial,structures
R389 T2811 T2809 pobj structures,of
R390 T2871 T2870 prep of,development
R391 T2812 T2811 acl derived,structures
R392 T2813 T2812 prep from,derived
R393 T2814 T2815 det the,arteries
R394 T2872 T2873 det the,tract
R395 T2815 T2813 pobj arteries,from
R396 T2816 T2817 amod aortic,arch
R397 T2817 T2815 compound arch,arteries
R398 T2873 T2871 pobj tract,of
R399 T2874 T2873 amod cardiac,tract
R400 T2818 T2819 punct [,1
R401 T2819 T2798 parataxis 1,contribute
R402 T2875 T2873 compound outflow,tract
R403 T2820 T2821 punct -,3
R404 T2821 T2819 prep 3,1
R405 T2822 T2819 punct ],1
R406 T2876 T2865 auxpass was,demonstrated
R407 T2823 T2757 punct .,delaminate
R408 T2825 T2826 det A,subset
R409 T2877 T2865 advmod originally,demonstrated
R410 T2826 T2827 nsubj subset,continues
R411 T2878 T2865 agent by,demonstrated
R412 T2828 T2826 prep of,subset
R413 T2829 T2828 pobj CNCCs,of
R414 T2830 T2831 aux to,migrate
R415 T2831 T2827 xcomp migrate,continues
R416 T2832 T2831 advmod deeper,migrate
R417 T2833 T2831 prep into,migrate
R418 T2834 T2835 det the,sac
R419 T2879 T2880 amod pioneering,studies
R420 T2835 T2833 pobj sac,into
R421 T2836 T2835 amod aortic,sac
R422 T2880 T2878 pobj studies,by
R423 T2881 T2880 prep of,studies
R424 T2882 T2881 pobj Kirby,of
R425 T2883 T2882 cc and,Kirby
R426 T2884 T2882 conj coworkers,Kirby
R427 T2943 T2933 cc and,shown
R428 T2944 T2945 poss their,fate
R429 T2885 T2886 punct [,1
R430 T2945 T2946 nsubjpass fate,controlled
R431 T2946 T2933 conj controlled,shown
R432 T2947 T2946 auxpass is,controlled
R433 T2886 T2884 parataxis 1,coworkers
R434 T2948 T2946 advmod largely,controlled
R435 T2949 T2946 agent by,controlled
R436 T2887 T2886 punct ],1
R437 T2950 T2951 amod instructional,signals
R438 T2951 T2949 pobj signals,by
R439 T2888 T2882 punct ", ",Kirby
R440 T2952 T2951 prep from,signals
R441 T2953 T2954 amod local,environments
R442 T2889 T2890 dep who,showed
R443 T2954 T2952 pobj environments,from
R444 T2955 T2956 prep into,migrate
R445 T2956 T2954 relcl migrate,environments
R446 T2890 T2882 relcl showed,Kirby
R447 T2957 T2955 pobj which,into
R448 T2958 T2956 nsubj NCCs,migrate
R449 T2959 T2960 punct [,6
R450 T2891 T2892 mark that,led
R451 T2892 T2890 ccomp led,showed
R452 T2960 T2946 parataxis 6,controlled
R453 T2893 T2892 nsubj ablation,led
R454 T2961 T2960 punct ],6
R455 T2962 T2946 punct .,controlled
R456 T2894 T2893 prep of,ablation
R457 T2964 T2965 amod Several,studies
R458 T2965 T2967 nsubj studies,indicated
R459 T2895 T2896 det the,CNC
R460 T2966 T2965 amod recent,studies
R461 T2896 T2894 pobj CNC,of
R462 T2968 T2967 aux have,indicated
R463 T2969 T2970 mark that,are
R464 T2970 T2967 ccomp are,indicated
R465 T2897 T2893 prep in,ablation
R466 T2971 T2970 nsubj members,are
R467 T2972 T2971 prep of,members
R468 T2973 T2974 det the,superfamily
R469 T2974 T2972 pobj superfamily,of
R470 T2975 T2976 compound TGF,β
R471 T2898 T2899 det the,chick
R472 T2976 T2974 compound β,superfamily
R473 T2977 T2976 punct -,β
R474 T2978 T2971 punct ", ",members
R475 T2899 T2897 pobj chick,in
R476 T2979 T2980 advmod i.e.,βs
R477 T2980 T2971 appos βs,members
R478 T2900 T2892 prep to,led
R479 T2981 T2980 punct ", ",βs
R480 T2982 T2980 compound TGF,βs
R481 T2983 T2980 punct -,βs
R482 T2901 T2902 amod severe,tract
R483 T2984 T2980 cc and,βs
R484 T2985 T2980 conj BMPs,βs
R485 T2986 T2987 amod likely,candidates
R486 T2902 T2900 pobj tract,to
R487 T2987 T2970 attr candidates,are
R488 T2988 T2989 aux to,provide
R489 T2903 T2902 compound outflow,tract
R490 T2989 T2987 advcl provide,candidates
R491 T2990 T2989 dobj some,provide
R492 T2904 T2902 punct (,tract
R493 T2991 T2990 prep of,some
R494 T2992 T2993 det these,signals
R495 T2905 T2902 appos OFT,tract
R496 T2993 T2991 pobj signals,of
R497 T2994 T2967 punct .,indicated
R498 T2906 T2902 punct ),tract
R499 T2996 T2997 nsubj Mice,display
R500 T2907 T2902 nmod defects,tract
R501 T2998 T2996 amod deficient,Mice
R502 T2999 T2998 prep in,deficient
R503 T3000 T3001 compound TGF,β2
R504 T2908 T2902 prep including,tract
R505 T3001 T2999 pobj β2,in
R506 T3002 T3001 punct -,β2
R507 T3003 T3004 amod fourth,defects
R508 T2909 T2910 amod persistent,arteriosus
R509 T3004 T2997 dobj defects,display
R510 T3005 T3006 amod aortic,artery
R511 T3006 T3004 compound artery,defects
R512 T2910 T2908 pobj arteriosus,including
R513 T3007 T3006 compound arch,artery
R514 T3008 T3009 punct [,7
R515 T3009 T2997 parataxis 7,display
R516 T2911 T2910 compound truncus,arteriosus
R517 T3010 T3009 punct ],7
R518 T3011 T2997 punct ", ",display
R519 T2912 T2910 punct (,arteriosus
R520 T3012 T3013 mark while,results
R521 T3013 T2997 advcl results,display
R522 T3014 T3015 amod neural,cell
R523 T3015 T3017 npadvmod cell,specific
R524 T3016 T3015 compound crest,cell
R525 T3017 T3018 amod specific,abrogation
R526 T2913 T2910 appos PTA,arteriosus
R527 T3018 T3013 nsubj abrogation,results
R528 T3019 T3018 prep of,abrogation
R529 T3020 T3021 nmod TGF,β
R530 T2914 T2902 punct ),tract
R531 T3021 T3023 nmod β,receptor
R532 T3022 T3021 punct -,β
R533 T2915 T2902 punct ", ",tract
R534 T3023 T3019 pobj receptor,of
R535 T3024 T3023 nmod type,receptor
R536 T2916 T2902 conj mispatterning,tract
R537 T3025 T3023 nummod II,receptor
R538 T3026 T3023 punct (,receptor
R539 T3027 T3023 appos Tgfbr2,receptor
R540 T2917 T2916 prep of,mispatterning
R541 T3028 T3013 punct ),results
R542 T3029 T3013 prep in,results
R543 T3030 T3029 pobj interruption,in
R544 T2918 T2919 det the,vessels
R545 T3031 T3030 prep of,interruption
R546 T2919 T2917 pobj vessels,of
R547 T3032 T3033 det the,arch
R548 T3033 T3031 pobj arch,of
R549 T3034 T3033 amod aortic,arch
R550 T2920 T2919 amod great,vessels
R551 T3035 T3033 cc and,arch
R552 T3036 T3033 conj PTA,arch
R553 T3037 T3038 punct [,9
R554 T2921 T2916 cc and,mispatterning
R555 T3038 T3013 parataxis 9,results
R556 T3039 T3038 nummod 8,9
R557 T3040 T3038 punct ",",9
R558 T2922 T2923 compound outflow,tract
R559 T3041 T3038 punct ],9
R560 T3042 T2997 punct .,display
R561 T2923 T2924 compound tract,mal-alignments
R562 T3044 T3045 nmod BMPs,6
R563 T3045 T3046 nsubjpass 6,required
R564 T2924 T2916 conj mal-alignments,mispatterning
R565 T2925 T2926 punct [,5
R566 T3047 T3045 cc and,6
R567 T2926 T2892 parataxis 5,led
R568 T2927 T2926 punct ],5
R569 T2928 T2865 punct .,demonstrated
R570 T3048 T3049 punct -,7
R571 T2930 T2931 advmod Early,CNCCs
R572 T3049 T3045 conj 7,6
R573 T3050 T3046 auxpass are,required
R574 T3051 T3046 prep for,required
R575 T3052 T3053 amod proper,formation
R576 T3053 T3051 pobj formation,for
R577 T3054 T3053 prep of,formation
R578 T3055 T3056 det the,cushions
R579 T2931 T2933 nsubjpass CNCCs,shown
R580 T3056 T3054 pobj cushions,of
R581 T3057 T3058 compound outflow,tract
R582 T2932 T2931 amod migratory,CNCCs
R583 T3058 T3056 compound tract,cushions
R584 T3059 T3060 punct [,10
R585 T3060 T3053 parataxis 10,formation
R586 T2934 T2933 aux have,shown
R587 T3061 T3060 punct ],10
R588 T3062 T3046 punct ", ",required
R589 T3063 T3064 mark while,needed
R590 T2935 T2933 auxpass been,shown
R591 T3064 T3046 advcl needed,required
R592 T3065 T3066 nmod BMP,receptor
R593 T3066 T3064 nsubjpass receptor,needed
R594 T2936 T2937 aux to,retain
R595 T3067 T3066 nmod type,receptor
R596 T3068 T3067 nummod II,type
R597 T3069 T3064 auxpass is,needed
R598 T2937 T2933 xcomp retain,shown
R599 T3070 T3064 prep for,needed
R600 T3071 T3072 amod proper,development
R601 T2938 T2939 det a,degree
R602 T3072 T3070 pobj development,for
R603 T3073 T3072 prep of,development
R604 T3074 T3075 det the,ridges
R605 T2939 T2937 dobj degree,retain
R606 T3075 T3073 pobj ridges,of
R607 T3076 T3075 amod conotruncal,ridges
R608 T3077 T3078 punct [,11
R609 T2940 T2939 amod considerable,degree
R610 T3078 T3046 parataxis 11,required
R611 T3079 T3078 punct ],11
R612 T2941 T2939 prep of,degree
R613 T3080 T3046 punct .,required
R614 T3082 T3083 advmod Moreover,shown
R615 T2942 T2941 pobj plasticity,of
R616 T3084 T3083 punct ", ",shown
R617 T3153 T3152 pobj phosphorylation,to
R618 T3085 T3086 amod neural,crest
R619 T3086 T3087 npadvmod crest,specific
R620 T3087 T3089 amod specific,deletion
R621 T3088 T3087 punct -,specific
R622 T3154 T3153 cc and,phosphorylation
R623 T3089 T3083 nsubjpass deletion,shown
R624 T3090 T3089 prep of,deletion
R625 T3091 T3092 det the,Alk2
R626 T3092 T3090 pobj Alk2,of
R627 T3093 T3092 nmod BMP,Alk2
R628 T3094 T3092 nmod type,Alk2
R629 T3155 T3153 conj activation,phosphorylation
R630 T3095 T3094 nummod I,type
R631 T3096 T3092 compound receptors,Alk2
R632 T3097 T3092 cc and,Alk2
R633 T3156 T3153 prep of,phosphorylation
R634 T3098 T3092 conj Alk3,Alk2
R635 T3099 T3083 aux has,shown
R636 T3100 T3083 auxpass been,shown
R637 T3101 T3102 aux to,lead
R638 T3157 T3158 nmod type,receptors
R639 T3102 T3083 xcomp lead,shown
R640 T3103 T3102 prep to,lead
R641 T3158 T3156 pobj receptors,of
R642 T3104 T3105 amod defective,septation
R643 T3105 T3103 pobj septation,to
R644 T3106 T3107 amod aortico,pulmonary
R645 T3159 T3157 nummod I,type
R646 T3107 T3105 amod pulmonary,septation
R647 T3108 T3107 punct -,pulmonary
R648 T3160 T3153 punct ", ",phosphorylation
R649 T3109 T3105 punct ", ",septation
R650 T3110 T3105 prep among,septation
R651 T3111 T3112 amod other,defects
R652 T3161 T3162 dep which,phosphorylate
R653 T3112 T3110 pobj defects,among
R654 T3162 T3153 relcl phosphorylate,phosphorylation
R655 T3113 T3112 amod cardiac,defects
R656 T3163 T3162 punct ", ",phosphorylate
R657 T3114 T3115 punct [,13
R658 T3164 T3162 prep in,phosphorylate
R659 T3115 T3083 parataxis 13,shown
R660 T3116 T3115 nummod 12,13
R661 T3117 T3115 punct ",",13
R662 T3165 T3164 pobj turn,in
R663 T3118 T3115 punct ],13
R664 T3119 T3083 punct .,shown
R665 T3166 T3162 punct ", ",phosphorylate
R666 T3121 T3122 compound TGF,β
R667 T3122 T3124 compound β,ligands
R668 T3167 T3162 cc and,phosphorylate
R669 T3123 T3122 punct -,β
R670 T3124 T3126 nsubj ligands,signal
R671 T3125 T3124 compound subfamily,ligands
R672 T3168 T3162 conj activate,phosphorylate
R673 T3127 T3126 prep via,signal
R674 T3169 T3170 det a,set
R675 T3128 T3129 det a,complex
R676 T3129 T3127 pobj complex,via
R677 T3130 T3129 compound receptor,complex
R678 T3131 T3129 acl composed,complex
R679 T3132 T3131 prep of,composed
R680 T3170 T3168 dobj set,activate
R681 T3133 T3134 nummod two,receptors
R682 T3134 T3132 pobj receptors,of
R683 T3135 T3134 nmod type,receptors
R684 T3171 T3170 amod specific,set
R685 T3136 T3135 nummod II,type
R686 T3137 T3134 cc and,receptors
R687 T3138 T3139 nummod two,receptors
R688 T3172 T3170 prep of,set
R689 T3139 T3134 conj receptors,receptors
R690 T3140 T3139 nmod type,receptors
R691 T3173 T3174 amod downstream,molecules
R692 T3141 T3140 nummod I,type
R693 T3142 T3143 punct [,15
R694 T3174 T3172 pobj molecules,of
R695 T3143 T3126 parataxis 15,signal
R696 T3144 T3143 nummod 14,15
R697 T3145 T3143 punct ",",15
R698 T3146 T3143 punct ],15
R699 T3175 T3174 compound signaling,molecules
R700 T3147 T3126 punct .,signal
R701 T3176 T3174 acl called,molecules
R702 T3149 T3150 compound Ligand,binding
R703 T3150 T3151 nsubj binding,leads
R704 T3177 T3176 oprd Smads,called
R705 T3152 T3151 prep to,leads
R706 T3178 T3151 punct .,leads
R707 T3180 T3181 prep In,bind
R708 T3259 T3254 ccomp are,is
R709 T3182 T3183 amod general,terms
R710 T3260 T3261 det these,interactions
R711 T3261 T3259 nsubj interactions,are
R712 T3262 T3261 compound signaling,interactions
R713 T3183 T3180 pobj terms,In
R714 T3263 T3264 advmod more,complex
R715 T3184 T3181 punct ", ",bind
R716 T3264 T3259 acomp complex,are
R717 T3265 T3266 advmod in,vivo
R718 T3185 T3186 compound TGF,βs
R719 T3266 T3259 advmod vivo,are
R720 T3267 T3259 punct ", ",are
R721 T3268 T3269 advmod possibly,allowing
R722 T3186 T3181 nsubj βs,bind
R723 T3269 T3259 advcl allowing,are
R724 T3270 T3269 dobj formation,allowing
R725 T3271 T3270 prep of,formation
R726 T3187 T3186 punct -,βs
R727 T3272 T3273 amod heterotetrameric,complexes
R728 T3273 T3271 pobj complexes,of
R729 T3274 T3273 acl composed,complexes
R730 T3275 T3274 prep of,composed
R731 T3276 T3277 amod different,receptors
R732 T3277 T3275 pobj receptors,of
R733 T3188 T3181 prep to,bind
R734 T3278 T3277 nmod type,receptors
R735 T3279 T3278 nummod II,type
R736 T3280 T3278 cc and,type
R737 T3281 T3278 conj type,type
R738 T3189 T3190 det the,receptor
R739 T3282 T3281 nummod I,type
R740 T3283 T3284 punct [,16
R741 T3284 T3259 parataxis 16,are
R742 T3190 T3188 pobj receptor,to
R743 T3285 T3284 punct ],16
R744 T3286 T3254 punct .,is
R745 T3191 T3192 nmod TGF,β
R746 T3288 T3289 prep In,identified
R747 T3192 T3190 nmod β,receptor
R748 T3290 T3288 pobj addition,In
R749 T3291 T3289 punct ", ",identified
R750 T3292 T3293 amod recent,studies
R751 T3193 T3192 punct -,β
R752 T3293 T3289 nsubj studies,identified
R753 T3294 T3289 aux have,identified
R754 T3295 T3296 amod novel,ligands
R755 T3194 T3190 nmod type,receptor
R756 T3296 T3289 dobj ligands,identified
R757 T3297 T3298 compound TGF,β
R758 T3298 T3300 npadvmod β,related
R759 T3195 T3194 nummod II,type
R760 T3299 T3298 punct -,β
R761 T3300 T3296 amod related,ligands
R762 T3301 T3300 punct -,related
R763 T3196 T3190 punct (,receptor
R764 T3197 T3190 appos TGFβRII,receptor
R765 T3302 T3296 punct ", ",ligands
R766 T3303 T3304 dep which,bind
R767 T3304 T3296 relcl bind,ligands
R768 T3198 T3190 punct ),receptor
R769 T3305 T3304 aux can,bind
R770 T3306 T3304 prep to,bind
R771 T3199 T3190 cc and,receptor
R772 T3307 T3308 amod entire,combinations
R773 T3308 T3306 pobj combinations,to
R774 T3309 T3308 amod different,combinations
R775 T3200 T3201 nmod TGF,β
R776 T3310 T3308 prep of,combinations
R777 T3311 T3310 pobj receptors,of
R778 T3201 T3203 nmod β,receptor
R779 T3312 T3289 punct .,identified
R780 T3202 T3201 punct -,β
R781 T3314 T3315 prep For,bind
R782 T3316 T3314 pobj instance,For
R783 T3317 T3315 punct ", ",bind
R784 T3318 T3319 nmod growth,factors
R785 T3319 T3315 nsubj factors,bind
R786 T3203 T3190 conj receptor,receptor
R787 T3320 T3318 cc and,growth
R788 T3321 T3318 conj differentiation,growth
R789 T3322 T3319 punct (,factors
R790 T3323 T3319 appos GDFs,factors
R791 T3204 T3203 nmod type,receptor
R792 T3324 T3319 punct ),factors
R793 T3325 T3319 appos 8,factors
R794 T3205 T3204 nummod I,type
R795 T3326 T3325 cc and,8
R796 T3327 T3325 conj 9,8
R797 T3328 T3315 aux can,bind
R798 T3206 T3203 punct (,receptor
R799 T3329 T3315 prep to,bind
R800 T3330 T3331 nmod Activin,receptor
R801 T3331 T3329 pobj receptor,to
R802 T3332 T3331 nmod type,receptor
R803 T3207 T3203 appos ALK5,receptor
R804 T3333 T3332 nummod II,type
R805 T3334 T3331 cc and,receptor
R806 T3208 T3181 punct ),bind
R807 T3335 T3331 conj ALK5,receptor
R808 T3336 T3337 aux to,activate
R809 T3337 T3315 advcl activate,bind
R810 T3209 T3181 advcl activating,bind
R811 T3338 T3339 compound TGF,β
R812 T3339 T3341 compound β,Smads
R813 T3340 T3339 punct -,β
R814 T3210 T3211 compound TGF,β
R815 T3341 T3337 dobj Smads,activate
R816 T3342 T3343 punct [,18
R817 T3211 T3213 compound β,Smads
R818 T3343 T3315 parataxis 18,bind
R819 T3344 T3343 nummod 17,18
R820 T3345 T3343 punct ",",18
R821 T3212 T3211 punct -,β
R822 T3346 T3343 punct ],18
R823 T3347 T3315 punct .,bind
R824 T3213 T3209 dobj Smads,activating
R825 T3349 T3350 advmod Therefore,hypothesized
R826 T3214 T3215 punct (,2
R827 T3351 T3350 punct ", ",hypothesized
R828 T3352 T3350 nsubj we,hypothesized
R829 T3353 T3354 mark that,reveal
R830 T3215 T3209 parataxis 2,activating
R831 T3354 T3350 ccomp reveal,hypothesized
R832 T3355 T3354 nsubj deletion,reveal
R833 T3356 T3355 prep of,deletion
R834 T3357 T3356 pobj Alk5,of
R835 T3358 T3355 prep in,deletion
R836 T3359 T3360 det a,lineage
R837 T3216 T3215 cc and,2
R838 T3360 T3358 pobj lineage,in
R839 T3361 T3360 amod specific,lineage
R840 T3362 T3360 compound cell,lineage
R841 T3217 T3215 conj 3,2
R842 T3363 T3354 aux should,reveal
R843 T3364 T3354 dobj phenotypes,reveal
R844 T3218 T3215 punct ),2
R845 T3219 T3181 punct ", ",bind
R846 T3220 T3221 mark while,bind
R847 T3221 T3181 advcl bind,bind
R848 T3365 T3366 dep which,seen
R849 T3366 T3364 relcl seen,phenotypes
R850 T3222 T3221 nsubj BMPs,bind
R851 T3367 T3366 aux can,seen
R852 T3368 T3366 neg not,seen
R853 T3369 T3366 auxpass be,seen
R854 T3223 T3221 prep to,bind
R855 T3370 T3366 prep in,seen
R856 T3371 T3372 amod comparable,mutants
R857 T3224 T3225 det the,ALK2
R858 T3372 T3370 pobj mutants,in
R859 T3373 T3372 acl lacking,mutants
R860 T3225 T3223 pobj ALK2,to
R861 T3374 T3373 dobj Tgfbr2,lacking
R862 T3375 T3350 punct .,hypothesized
R863 T3226 T3225 nmod BMP,ALK2
R864 T3377 T3378 advmod Indeed,showed
R865 T3378 T3382 ccomp showed,seen
R866 T3379 T3378 punct ", ",showed
R867 T3227 T3228 nmod type,receptor
R868 T3380 T3378 nsubj we,showed
R869 T3381 T3378 advmod recently,showed
R870 T3228 T3225 nmod receptor,ALK2
R871 T3383 T3384 mark that,display
R872 T3229 T3227 nummod II,type
R873 T3230 T3228 cc and,receptor
R874 T3384 T3378 ccomp display,showed
R875 T3231 T3232 nmod type,receptors
R876 T3385 T3386 amod neural,cell
R877 T3386 T3388 npadvmod cell,specific
R878 T3387 T3386 compound crest,cell
R879 T3232 T3228 conj receptors,receptor
R880 T3388 T3389 amod specific,mutants
R881 T3389 T3384 nsubj mutants,display
R882 T3233 T3231 nummod I,type
R883 T3390 T3389 compound Alk5,mutants
R884 T3391 T3392 det a,spectrum
R885 T3392 T3384 dobj spectrum,display
R886 T3393 T3392 amod unique,spectrum
R887 T3394 T3392 prep of,spectrum
R888 T3234 T3225 punct ", ",ALK2
R889 T3395 T3396 amod craniofacial,defects
R890 T3396 T3394 pobj defects,of
R891 T3397 T3396 amod developmental,defects
R892 T3235 T3225 punct -,ALK2
R893 T3398 T3396 punct ", ",defects
R894 T3399 T3400 advmod e.g.,snout
R895 T3236 T3225 nummod 3,ALK2
R896 T3400 T3396 appos snout,defects
R897 T3401 T3400 punct ", ",snout
R898 T3237 T3225 punct ", ",ALK2
R899 T3402 T3400 compound cleft,snout
R900 T3403 T3400 cc and,snout
R901 T3404 T3405 amod severe,hypoplasia
R902 T3238 T3225 cc or,ALK2
R903 T3405 T3400 conj hypoplasia,snout
R904 T3406 T3405 amod mandibular,hypoplasia
R905 T3407 T3408 punct [,19
R906 T3239 T3225 conj 6,ALK2
R907 T3408 T3378 parataxis 19,showed
R908 T3409 T3408 punct ],19
R909 T3240 T3221 punct ", ",bind
R910 T3410 T3382 punct ;,seen
R911 T3411 T3412 det these,phenotypes
R912 T3412 T3382 nsubjpass phenotypes,seen
R913 T3241 T3221 advcl activating,bind
R914 T3413 T3382 auxpass were,seen
R915 T3414 T3382 neg not,seen
R916 T3242 T3243 compound BMP,Smads
R917 T3415 T3382 prep in,seen
R918 T3416 T3417 amod corresponding,mutants
R919 T3417 T3415 pobj mutants,in
R920 T3243 T3241 dobj Smads,activating
R921 T3418 T3417 compound Tgfbr2,mutants
R922 T3419 T3420 punct [,20
R923 T3420 T3382 parataxis 20,seen
R924 T3244 T3245 punct (,1
R925 T3421 T3420 punct ],20
R926 T3422 T3382 punct .,seen
R927 T3245 T3181 parataxis 1,bind
R928 T3424 T3425 aux To,determine
R929 T3425 T3426 advcl determine,focused
R930 T3246 T3245 punct ", ",1
R931 T3427 T3425 punct ", ",determine
R932 T3247 T3245 conj 5,1
R933 T3428 T3429 mark whether,mediate
R934 T3429 T3425 ccomp mediate,determine
R935 T3430 T3429 nsubj ALK5,mediate
R936 T3248 T3247 cc and,5
R937 T3431 T3429 aux would,mediate
R938 T3432 T3429 advmod also,mediate
R939 T3433 T3434 amod unique,events
R940 T3434 T3429 dobj events,mediate
R941 T3249 T3247 conj 8,5
R942 T3435 T3434 amod non-redundant,events
R943 T3436 T3434 compound signaling,events
R944 T3437 T3429 prep in,mediate
R945 T3250 T3245 punct ),1
R946 T3438 T3439 amod cardiac,crest
R947 T3439 T3441 compound crest,cells
R948 T3440 T3439 amod neural,crest
R949 T3251 T3181 punct .,bind
R950 T3441 T3437 pobj cells,in
R951 T3442 T3426 punct ", ",focused
R952 T3443 T3426 nsubj we,focused
R953 T3253 T3254 advmod However,is
R954 T3444 T3426 prep on,focused
R955 T3445 T3446 amod cardiac,phenotypes
R956 T3255 T3254 punct ", ",is
R957 T3446 T3444 pobj phenotypes,on
R958 T3447 T3445 cc and,cardiac
R959 T3256 T3254 nsubj it,is
R960 T3448 T3445 conj pharyngeal,cardiac
R961 T3449 T3446 prep of,phenotypes
R962 T3450 T3451 compound mouse,embryos
R963 T3257 T3254 acomp likely,is
R964 T3451 T3449 pobj embryos,of
R965 T3452 T3451 acl lacking,embryos
R966 T3453 T3452 dobj Alk5,lacking
R967 T3258 T3259 mark that,are
R968 T3454 T3455 advmod specifically,in
R969 T3455 T3426 prep in,focused
R970 T3471 T3465 pobj mutants,in
R971 T3456 T3457 amod neural,cells
R972 T3457 T3455 pobj cells,in
R973 T3458 T3457 compound crest,cells
R974 T3459 T3426 punct .,focused
R975 T3472 T3464 punct ", ",fail
R976 T3461 T3462 nsubj We,discovered
R977 T3463 T3464 mark that,fail
R978 T3473 T3474 amod pharyngeal,organs
R979 T3464 T3462 ccomp fail,discovered
R980 T3465 T3464 prep in,fail
R981 T3474 T3464 nsubj organs,fail
R982 T3466 T3467 compound Alk5,Cre
R983 T3467 T3471 compound Cre,mutants
R984 T3468 T3467 punct /,Cre
R985 T3475 T3474 punct (,organs
R986 T3469 T3467 compound Wnt1,Cre
R987 T3470 T3467 punct -,Cre
R988 T3476 T3474 appos thymus,organs
R989 T3477 T3476 cc and,thymus
R990 T3478 T3476 conj parathyroid,thymus
R991 T3577 T3541 punct .,differ
R992 T3479 T3464 punct ),fail
R993 T3480 T3481 aux to,migrate
R994 T3481 T3464 xcomp migrate,fail
R995 T3482 T3481 advmod appropriately,migrate
R996 T3483 T3462 punct .,discovered
R997 T3485 T3486 advmod Moreover,display
R998 T3487 T3486 punct ", ",display
R999 T3488 T3489 det the,embryos