Id |
Subject |
Object |
Predicate |
Lexical cue |
T6831 |
0-7 |
JJ |
denotes |
Cardiac |
T6832 |
8-12 |
NNS |
denotes |
NCCs |
T6834 |
13-22 |
JJ |
denotes |
deficient |
T6835 |
23-25 |
IN |
denotes |
in |
T6836 |
26-30 |
NN |
denotes |
Alk5 |
T6837 |
31-34 |
MD |
denotes |
can |
T6833 |
35-43 |
VB |
denotes |
populate |
T6838 |
44-47 |
DT |
denotes |
the |
T6840 |
48-55 |
NN |
denotes |
outflow |
T6839 |
56-61 |
NN |
denotes |
tract |
T6841 |
61-187 |
sentence |
denotes |
Next we used the R26R lineage-tracing assay to determine whether CNCCs could appropriately populate the outflow tract region. |
T6842 |
62-66 |
RB |
denotes |
Next |
T6844 |
67-69 |
PRP |
denotes |
we |
T6843 |
70-74 |
VBD |
denotes |
used |
T6845 |
75-78 |
DT |
denotes |
the |
T6847 |
79-83 |
NN |
denotes |
R26R |
T6848 |
84-91 |
NN |
denotes |
lineage |
T6849 |
91-92 |
HYPH |
denotes |
- |
T6850 |
92-99 |
VBG |
denotes |
tracing |
T6846 |
100-105 |
NN |
denotes |
assay |
T6851 |
106-108 |
TO |
denotes |
to |
T6852 |
109-118 |
VB |
denotes |
determine |
T6853 |
119-126 |
IN |
denotes |
whether |
T6855 |
127-132 |
NNS |
denotes |
CNCCs |
T6856 |
133-138 |
MD |
denotes |
could |
T6857 |
139-152 |
RB |
denotes |
appropriately |
T6854 |
153-161 |
VB |
denotes |
populate |
T6858 |
162-165 |
DT |
denotes |
the |
T6860 |
166-173 |
NN |
denotes |
outflow |
T6861 |
174-179 |
NN |
denotes |
tract |
T6859 |
180-186 |
NN |
denotes |
region |
T6862 |
186-187 |
. |
denotes |
. |
T6863 |
187-356 |
sentence |
denotes |
Briefly, Alk5Flox/Flox mice were crossed with the ROSA26 Cre reporter mice, and subsequently Alk5Flox/Flox;R26R(+/+) females were crossed with Alk5KO/WT;Wnt1-Cre males. |
T6864 |
188-195 |
RB |
denotes |
Briefly |
T6866 |
195-197 |
, |
denotes |
, |
T6867 |
197-205 |
NN |
denotes |
Alk5Flox |
T6869 |
205-206 |
HYPH |
denotes |
/ |
T6868 |
206-210 |
NN |
denotes |
Flox |
T6870 |
211-215 |
NNS |
denotes |
mice |
T6871 |
216-220 |
VBD |
denotes |
were |
T6865 |
221-228 |
VBN |
denotes |
crossed |
T6872 |
229-233 |
IN |
denotes |
with |
T6873 |
234-237 |
DT |
denotes |
the |
T6875 |
238-244 |
NN |
denotes |
ROSA26 |
T6877 |
245-248 |
NN |
denotes |
Cre |
T6876 |
249-257 |
NN |
denotes |
reporter |
T6874 |
258-262 |
NNS |
denotes |
mice |
T6878 |
262-264 |
, |
denotes |
, |
T6879 |
264-267 |
CC |
denotes |
and |
T6880 |
268-280 |
RB |
denotes |
subsequently |
T6882 |
281-289 |
NN |
denotes |
Alk5Flox |
T6884 |
289-290 |
HYPH |
denotes |
/ |
T6883 |
290-294 |
NN |
denotes |
Flox |
T6886 |
294-295 |
: |
denotes |
; |
T6887 |
295-299 |
NN |
denotes |
R26R |
T6888 |
299-300 |
-LRB- |
denotes |
( |
T6889 |
300-301 |
SYM |
denotes |
+ |
T6890 |
301-302 |
HYPH |
denotes |
/ |
T6885 |
302-303 |
SYM |
denotes |
+ |
T6892 |
303-304 |
-RRB- |
denotes |
) |
T6891 |
305-312 |
NNS |
denotes |
females |
T6893 |
313-317 |
VBD |
denotes |
were |
T6881 |
318-325 |
VBN |
denotes |
crossed |
T6894 |
326-330 |
IN |
denotes |
with |
T6895 |
331-337 |
NN |
denotes |
Alk5KO |
T6897 |
337-338 |
HYPH |
denotes |
/ |
T6898 |
338-340 |
NN |
denotes |
WT |
T6899 |
340-341 |
: |
denotes |
; |
T6900 |
341-345 |
NN |
denotes |
Wnt1 |
T6901 |
345-346 |
HYPH |
denotes |
- |
T6896 |
346-349 |
NN |
denotes |
Cre |
T6902 |
350-355 |
NNS |
denotes |
males |
T6903 |
355-356 |
. |
denotes |
. |
T6904 |
356-530 |
sentence |
denotes |
The resulting embryos had the NC-lineage permanently labeled with β-galactosidase expression, and displayed identical phenotypes to those obtained without the R26R reporter. |
T6905 |
357-360 |
DT |
denotes |
The |
T6907 |
361-370 |
VBG |
denotes |
resulting |
T6906 |
371-378 |
NNS |
denotes |
embryos |
T6908 |
379-382 |
VBD |
denotes |
had |
T6909 |
383-386 |
DT |
denotes |
the |
T6911 |
387-389 |
NN |
denotes |
NC |
T6912 |
389-390 |
HYPH |
denotes |
- |
T6910 |
390-397 |
NN |
denotes |
lineage |
T6914 |
398-409 |
RB |
denotes |
permanently |
T6913 |
410-417 |
VBN |
denotes |
labeled |
T6915 |
418-422 |
IN |
denotes |
with |
T6916 |
423-424 |
NN |
denotes |
β |
T6918 |
424-425 |
HYPH |
denotes |
- |
T6919 |
425-438 |
NN |
denotes |
galactosidase |
T6917 |
439-449 |
NN |
denotes |
expression |
T6920 |
449-451 |
, |
denotes |
, |
T6921 |
451-454 |
CC |
denotes |
and |
T6922 |
455-464 |
VBD |
denotes |
displayed |
T6923 |
465-474 |
JJ |
denotes |
identical |
T6924 |
475-485 |
NNS |
denotes |
phenotypes |
T6925 |
486-488 |
IN |
denotes |
to |
T6926 |
489-494 |
DT |
denotes |
those |
T6927 |
495-503 |
VBN |
denotes |
obtained |
T6928 |
504-511 |
IN |
denotes |
without |
T6929 |
512-515 |
DT |
denotes |
the |
T6931 |
516-520 |
NN |
denotes |
R26R |
T6930 |
521-529 |
NN |
denotes |
reporter |
T6932 |
529-530 |
. |
denotes |
. |
T6933 |
530-682 |
sentence |
denotes |
Staining of embryos for β-galactosidase at E8-E11 did not reveal detectable differences in NCC migration between mutants and controls (data not shown). |
T6934 |
531-539 |
NN |
denotes |
Staining |
T6936 |
540-542 |
IN |
denotes |
of |
T6937 |
543-550 |
NNS |
denotes |
embryos |
T6938 |
551-554 |
IN |
denotes |
for |
T6939 |
555-556 |
NN |
denotes |
β |
T6941 |
556-557 |
HYPH |
denotes |
- |
T6940 |
557-570 |
NN |
denotes |
galactosidase |
T6942 |
571-573 |
IN |
denotes |
at |
T6943 |
574-576 |
NN |
denotes |
E8 |
T6944 |
576-577 |
SYM |
denotes |
- |
T6945 |
577-580 |
NN |
denotes |
E11 |
T6946 |
581-584 |
VBD |
denotes |
did |
T6947 |
585-588 |
RB |
denotes |
not |
T6935 |
589-595 |
VB |
denotes |
reveal |
T6948 |
596-606 |
JJ |
denotes |
detectable |
T6949 |
607-618 |
NNS |
denotes |
differences |
T6950 |
619-621 |
IN |
denotes |
in |
T6951 |
622-625 |
NN |
denotes |
NCC |
T6952 |
626-635 |
NN |
denotes |
migration |
T6953 |
636-643 |
IN |
denotes |
between |
T6954 |
644-651 |
NNS |
denotes |
mutants |
T6955 |
652-655 |
CC |
denotes |
and |
T6956 |
656-664 |
NNS |
denotes |
controls |
T6957 |
665-666 |
-LRB- |
denotes |
( |
T6959 |
666-670 |
NNS |
denotes |
data |
T6960 |
671-674 |
RB |
denotes |
not |
T6958 |
675-680 |
VBN |
denotes |
shown |
T6961 |
680-681 |
-RRB- |
denotes |
) |
T6962 |
681-682 |
. |
denotes |
. |
T6963 |
682-989 |
sentence |
denotes |
Similarly, serial transverse sectioning of whole mount embryos (E10-E12) and subsequent analysis of positively stained cells in the OFT region demonstrated that CNCCs deficient in Alk5 were capable of populating the PAAs, aortic sac and conotruncal ridges at a level comparable to that of controls (Fig 4). |
T6964 |
683-692 |
RB |
denotes |
Similarly |
T6966 |
692-694 |
, |
denotes |
, |
T6967 |
694-700 |
JJ |
denotes |
serial |
T6969 |
701-711 |
JJ |
denotes |
transverse |
T6968 |
712-722 |
NN |
denotes |
sectioning |
T6970 |
723-725 |
IN |
denotes |
of |
T6971 |
726-731 |
JJ |
denotes |
whole |
T6972 |
732-737 |
NN |
denotes |
mount |
T6973 |
738-745 |
NNS |
denotes |
embryos |
T6974 |
746-747 |
-LRB- |
denotes |
( |
T6975 |
747-750 |
NN |
denotes |
E10 |
T6976 |
750-751 |
SYM |
denotes |
- |
T6977 |
751-754 |
NN |
denotes |
E12 |
T6978 |
754-755 |
-RRB- |
denotes |
) |
T6979 |
756-759 |
CC |
denotes |
and |
T6980 |
760-770 |
JJ |
denotes |
subsequent |
T6981 |
771-779 |
NN |
denotes |
analysis |
T6982 |
780-782 |
IN |
denotes |
of |
T6983 |
783-793 |
RB |
denotes |
positively |
T6984 |
794-801 |
VBN |
denotes |
stained |
T6985 |
802-807 |
NNS |
denotes |
cells |
T6986 |
808-810 |
IN |
denotes |
in |
T6987 |
811-814 |
DT |
denotes |
the |
T6989 |
815-818 |
NN |
denotes |
OFT |
T6988 |
819-825 |
NN |
denotes |
region |
T6965 |
826-838 |
VBD |
denotes |
demonstrated |
T6990 |
839-843 |
IN |
denotes |
that |
T6992 |
844-849 |
NNS |
denotes |
CNCCs |
T6993 |
850-859 |
JJ |
denotes |
deficient |
T6994 |
860-862 |
IN |
denotes |
in |
T6995 |
863-867 |
NN |
denotes |
Alk5 |
T6991 |
868-872 |
VBD |
denotes |
were |
T6996 |
873-880 |
JJ |
denotes |
capable |
T6997 |
881-883 |
IN |
denotes |
of |
T6998 |
884-894 |
VBG |
denotes |
populating |
T6999 |
895-898 |
DT |
denotes |
the |
T7000 |
899-903 |
NNS |
denotes |
PAAs |
T7001 |
903-905 |
, |
denotes |
, |
T7002 |
905-911 |
JJ |
denotes |
aortic |
T7003 |
912-915 |
NN |
denotes |
sac |
T7004 |
916-919 |
CC |
denotes |
and |
T7005 |
920-931 |
JJ |
denotes |
conotruncal |
T7006 |
932-938 |
NNS |
denotes |
ridges |
T7007 |
939-941 |
IN |
denotes |
at |
T7008 |
942-943 |
DT |
denotes |
a |
T7009 |
944-949 |
NN |
denotes |
level |
T7010 |
950-960 |
JJ |
denotes |
comparable |
T7011 |
961-963 |
IN |
denotes |
to |
T7012 |
964-968 |
DT |
denotes |
that |
T7013 |
969-971 |
IN |
denotes |
of |
T7014 |
972-980 |
NNS |
denotes |
controls |
T7015 |
981-982 |
-LRB- |
denotes |
( |
T7016 |
982-985 |
NN |
denotes |
Fig |
T7017 |
986-987 |
CD |
denotes |
4 |
T7018 |
987-988 |
-RRB- |
denotes |
) |
T7019 |
988-989 |
. |
denotes |
. |
T7020 |
989-1151 |
sentence |
denotes |
To conclude, the observed phenotypes in Alk5/Wnt1-Cre mutants were certainly not due to defective migration of CNCCs to the pharyngeal and outflow tract regions. |
T7021 |
990-992 |
TO |
denotes |
To |
T7022 |
993-1001 |
VB |
denotes |
conclude |
T7024 |
1001-1003 |
, |
denotes |
, |
T7025 |
1003-1006 |
DT |
denotes |
the |
T7027 |
1007-1015 |
VBN |
denotes |
observed |
T7026 |
1016-1026 |
NNS |
denotes |
phenotypes |
T7028 |
1027-1029 |
IN |
denotes |
in |
T7029 |
1030-1034 |
NN |
denotes |
Alk5 |
T7031 |
1034-1035 |
HYPH |
denotes |
/ |
T7032 |
1035-1039 |
NN |
denotes |
Wnt1 |
T7033 |
1039-1040 |
HYPH |
denotes |
- |
T7030 |
1040-1043 |
NN |
denotes |
Cre |
T7034 |
1044-1051 |
NNS |
denotes |
mutants |
T7023 |
1052-1056 |
VBD |
denotes |
were |
T7035 |
1057-1066 |
RB |
denotes |
certainly |
T7036 |
1067-1070 |
RB |
denotes |
not |
T7037 |
1071-1074 |
IN |
denotes |
due |
T7038 |
1075-1077 |
IN |
denotes |
to |
T7039 |
1078-1087 |
JJ |
denotes |
defective |
T7040 |
1088-1097 |
NN |
denotes |
migration |
T7041 |
1098-1100 |
IN |
denotes |
of |
T7042 |
1101-1106 |
NNS |
denotes |
CNCCs |
T7043 |
1107-1109 |
IN |
denotes |
to |
T7044 |
1110-1113 |
DT |
denotes |
the |
T7046 |
1114-1124 |
JJ |
denotes |
pharyngeal |
T7047 |
1125-1128 |
CC |
denotes |
and |
T7048 |
1129-1136 |
NN |
denotes |
outflow |
T7049 |
1137-1142 |
NN |
denotes |
tract |
T7045 |
1143-1150 |
NNS |
denotes |
regions |
T7050 |
1150-1151 |
. |
denotes |
. |
T18898 |
1162-1168 |
JJ |
denotes |
Normal |
T18900 |
1169-1176 |
JJ |
denotes |
cardiac |
T18901 |
1177-1180 |
NN |
denotes |
NCC |
T18899 |
1181-1190 |
NN |
denotes |
migration |
T18902 |
1191-1193 |
IN |
denotes |
in |
T18903 |
1194-1198 |
NN |
denotes |
Alk5 |
T18905 |
1198-1199 |
HYPH |
denotes |
/ |
T18906 |
1199-1203 |
NN |
denotes |
Wnt1 |
T18907 |
1203-1204 |
HYPH |
denotes |
- |
T18904 |
1204-1207 |
NN |
denotes |
Cre |
T18908 |
1208-1215 |
NNS |
denotes |
mutants |
T18909 |
1215-1216 |
. |
denotes |
. |
T18910 |
1216-1377 |
sentence |
denotes |
The OFT of controls (A, C, E) and Alk5/Wnt1-Cre mutants (B, D, F) display similar staining patterns when analyzed using the R26R lineage tracing assay at E11.0. |
T18911 |
1217-1220 |
DT |
denotes |
The |
T18912 |
1221-1224 |
NN |
denotes |
OFT |
T18914 |
1225-1227 |
IN |
denotes |
of |
T18915 |
1228-1236 |
NNS |
denotes |
controls |
T18916 |
1237-1238 |
-LRB- |
denotes |
( |
T18918 |
1238-1239 |
NN |
denotes |
A |
T18919 |
1239-1241 |
, |
denotes |
, |
T18920 |
1241-1242 |
NN |
denotes |
C |
T18921 |
1242-1244 |
, |
denotes |
, |
T18917 |
1244-1245 |
NN |
denotes |
E |
T18922 |
1245-1246 |
-RRB- |
denotes |
) |
T18923 |
1247-1250 |
CC |
denotes |
and |
T18924 |
1251-1255 |
NN |
denotes |
Alk5 |
T18926 |
1255-1256 |
HYPH |
denotes |
/ |
T18927 |
1256-1260 |
NN |
denotes |
Wnt1 |
T18928 |
1260-1261 |
HYPH |
denotes |
- |
T18925 |
1261-1264 |
NN |
denotes |
Cre |
T18929 |
1265-1272 |
NNS |
denotes |
mutants |
T18930 |
1273-1274 |
-LRB- |
denotes |
( |
T18932 |
1274-1275 |
NN |
denotes |
B |
T18933 |
1275-1277 |
, |
denotes |
, |
T18934 |
1277-1278 |
NN |
denotes |
D |
T18935 |
1278-1280 |
, |
denotes |
, |
T18931 |
1280-1281 |
NN |
denotes |
F |
T18936 |
1281-1282 |
-RRB- |
denotes |
) |
T18913 |
1283-1290 |
VBP |
denotes |
display |
T18937 |
1291-1298 |
JJ |
denotes |
similar |
T18939 |
1299-1307 |
NN |
denotes |
staining |
T18938 |
1308-1316 |
NNS |
denotes |
patterns |
T18940 |
1317-1321 |
WRB |
denotes |
when |
T18941 |
1322-1330 |
VBN |
denotes |
analyzed |
T18942 |
1331-1336 |
VBG |
denotes |
using |
T18943 |
1337-1340 |
DT |
denotes |
the |
T18945 |
1341-1345 |
NN |
denotes |
R26R |
T18946 |
1346-1353 |
NN |
denotes |
lineage |
T18947 |
1354-1361 |
NN |
denotes |
tracing |
T18944 |
1362-1367 |
NN |
denotes |
assay |
T18948 |
1368-1370 |
IN |
denotes |
at |
T18949 |
1371-1376 |
NN |
denotes |
E11.0 |
T18950 |
1376-1377 |
. |
denotes |
. |
T18951 |
1377-1502 |
sentence |
denotes |
A-B, whole mount staining (left lateral image); C-F, transverse sections on the level of the 4th (C, D) and 6th (E, F) PAAs. |
T18952 |
1378-1379 |
LS |
denotes |
A |
T18954 |
1379-1380 |
SYM |
denotes |
- |
T18955 |
1380-1381 |
LS |
denotes |
B |
T18956 |
1381-1383 |
, |
denotes |
, |
T18957 |
1383-1388 |
JJ |
denotes |
whole |
T18958 |
1389-1394 |
NN |
denotes |
mount |
T18953 |
1395-1403 |
NN |
denotes |
staining |
T18959 |
1404-1405 |
-LRB- |
denotes |
( |
T18961 |
1405-1409 |
JJ |
denotes |
left |
T18962 |
1410-1417 |
JJ |
denotes |
lateral |
T18960 |
1418-1423 |
NN |
denotes |
image |
T18963 |
1423-1424 |
-RRB- |
denotes |
) |
T18964 |
1424-1425 |
: |
denotes |
; |
T18965 |
1426-1427 |
LS |
denotes |
C |
T18967 |
1427-1428 |
SYM |
denotes |
- |
T18968 |
1428-1429 |
LS |
denotes |
F |
T18969 |
1429-1431 |
, |
denotes |
, |
T18970 |
1431-1441 |
JJ |
denotes |
transverse |
T18966 |
1442-1450 |
NNS |
denotes |
sections |
T18971 |
1451-1453 |
IN |
denotes |
on |
T18972 |
1454-1457 |
DT |
denotes |
the |
T18973 |
1458-1463 |
NN |
denotes |
level |
T18974 |
1464-1466 |
IN |
denotes |
of |
T18975 |
1467-1470 |
DT |
denotes |
the |
T18977 |
1471-1474 |
JJ |
denotes |
4th |
T18978 |
1475-1476 |
-LRB- |
denotes |
( |
T18980 |
1476-1477 |
NN |
denotes |
C |
T18981 |
1477-1479 |
, |
denotes |
, |
T18979 |
1479-1480 |
NN |
denotes |
D |
T18982 |
1480-1481 |
-RRB- |
denotes |
) |
T18983 |
1482-1485 |
CC |
denotes |
and |
T18984 |
1486-1489 |
JJ |
denotes |
6th |
T18985 |
1490-1491 |
-LRB- |
denotes |
( |
T18987 |
1491-1492 |
NN |
denotes |
E |
T18988 |
1492-1494 |
, |
denotes |
, |
T18986 |
1494-1495 |
NN |
denotes |
F |
T18989 |
1495-1496 |
-RRB- |
denotes |
) |
T18976 |
1497-1501 |
NNS |
denotes |
PAAs |
T18990 |
1501-1502 |
. |
denotes |
. |
T18991 |
1502-1603 |
sentence |
denotes |
Arrows (A-F) point to the most proximal location staining positive for the β-galactosidase activity. |
T18992 |
1503-1509 |
NNS |
denotes |
Arrows |
T18994 |
1510-1511 |
-LRB- |
denotes |
( |
T18995 |
1511-1512 |
NN |
denotes |
A |
T18996 |
1512-1513 |
SYM |
denotes |
- |
T18997 |
1513-1514 |
NN |
denotes |
F |
T18998 |
1514-1515 |
-RRB- |
denotes |
) |
T18993 |
1516-1521 |
VBP |
denotes |
point |
T18999 |
1522-1524 |
IN |
denotes |
to |
T19000 |
1525-1528 |
DT |
denotes |
the |
T19002 |
1529-1533 |
RBS |
denotes |
most |
T19003 |
1534-1542 |
JJ |
denotes |
proximal |
T19001 |
1543-1551 |
NN |
denotes |
location |
T19004 |
1552-1560 |
VBG |
denotes |
staining |
T19005 |
1561-1569 |
JJ |
denotes |
positive |
T19006 |
1570-1573 |
IN |
denotes |
for |
T19007 |
1574-1577 |
DT |
denotes |
the |
T19009 |
1578-1579 |
NN |
denotes |
β |
T19011 |
1579-1580 |
HYPH |
denotes |
- |
T19010 |
1580-1593 |
NN |
denotes |
galactosidase |
T19008 |
1594-1602 |
NN |
denotes |
activity |
T19012 |
1602-1603 |
. |
denotes |
. |
R1969 |
T6831 |
T6832 |
amod |
Cardiac,NCCs |
R1970 |
T6832 |
T6833 |
nsubj |
NCCs,populate |
R1971 |
T6834 |
T6832 |
amod |
deficient,NCCs |
R1972 |
T6835 |
T6834 |
prep |
in,deficient |
R1973 |
T6836 |
T6835 |
pobj |
Alk5,in |
R1974 |
T6837 |
T6833 |
aux |
can,populate |
R1975 |
T6838 |
T6839 |
det |
the,tract |
R1976 |
T6839 |
T6833 |
dobj |
tract,populate |
R1977 |
T6840 |
T6839 |
compound |
outflow,tract |
R1978 |
T6842 |
T6843 |
advmod |
Next,used |
R1979 |
T6844 |
T6843 |
nsubj |
we,used |
R1980 |
T6845 |
T6846 |
det |
the,assay |
R1981 |
T6846 |
T6843 |
dobj |
assay,used |
R1982 |
T6847 |
T6846 |
nmod |
R26R,assay |
R1983 |
T6848 |
T6846 |
nmod |
lineage,assay |
R1984 |
T6849 |
T6848 |
punct |
-,lineage |
R1985 |
T6850 |
T6848 |
amod |
tracing,lineage |
R1986 |
T6851 |
T6852 |
aux |
to,determine |
R1987 |
T6852 |
T6843 |
advcl |
determine,used |
R1988 |
T6853 |
T6854 |
mark |
whether,populate |
R1989 |
T6854 |
T6852 |
ccomp |
populate,determine |
R1990 |
T6855 |
T6854 |
nsubj |
CNCCs,populate |
R1991 |
T6856 |
T6854 |
aux |
could,populate |
R1992 |
T6857 |
T6854 |
advmod |
appropriately,populate |
R1993 |
T6858 |
T6859 |
det |
the,region |
R1994 |
T6859 |
T6854 |
dobj |
region,populate |
R1995 |
T6860 |
T6861 |
compound |
outflow,tract |
R1996 |
T6861 |
T6859 |
compound |
tract,region |
R1997 |
T6862 |
T6843 |
punct |
.,used |
R1998 |
T6864 |
T6865 |
advmod |
Briefly,crossed |
R1999 |
T6866 |
T6865 |
punct |
", ",crossed |
R2000 |
T6867 |
T6868 |
compound |
Alk5Flox,Flox |
R2001 |
T6868 |
T6870 |
compound |
Flox,mice |
R2002 |
T6869 |
T6868 |
punct |
/,Flox |
R2003 |
T6870 |
T6865 |
nsubjpass |
mice,crossed |
R2004 |
T6871 |
T6865 |
auxpass |
were,crossed |
R2005 |
T6872 |
T6865 |
prep |
with,crossed |
R2006 |
T6873 |
T6874 |
det |
the,mice |
R2007 |
T6874 |
T6872 |
pobj |
mice,with |
R2008 |
T6875 |
T6876 |
compound |
ROSA26,reporter |
R2009 |
T6876 |
T6874 |
compound |
reporter,mice |
R2010 |
T6877 |
T6876 |
compound |
Cre,reporter |
R2011 |
T6878 |
T6865 |
punct |
", ",crossed |
R2012 |
T6879 |
T6865 |
cc |
and,crossed |
R2013 |
T6880 |
T6881 |
advmod |
subsequently,crossed |
R2014 |
T6881 |
T6865 |
conj |
crossed,crossed |
R2015 |
T6882 |
T6883 |
nmod |
Alk5Flox,Flox |
R2016 |
T6883 |
T6885 |
nmod |
Flox,+ |
R2017 |
T6884 |
T6883 |
punct |
/,Flox |
R2018 |
T6885 |
T6891 |
punct |
+,females |
R2019 |
T6886 |
T6885 |
punct |
;,+ |
R2020 |
T6887 |
T6885 |
nmod |
R26R,+ |
R2021 |
T6888 |
T6885 |
punct |
(,+ |
R2022 |
T6889 |
T6885 |
punct |
+,+ |
R2023 |
T6890 |
T6885 |
punct |
/,+ |
R2024 |
T6891 |
T6881 |
nsubjpass |
females,crossed |
R2025 |
T6892 |
T6885 |
punct |
),+ |
R2026 |
T6893 |
T6881 |
auxpass |
were,crossed |
R2027 |
T6894 |
T6881 |
prep |
with,crossed |
R2028 |
T6895 |
T6896 |
nmod |
Alk5KO,Cre |
R2029 |
T6896 |
T6902 |
compound |
Cre,males |
R2030 |
T6897 |
T6896 |
punct |
/,Cre |
R2031 |
T6898 |
T6896 |
nmod |
WT,Cre |
R2032 |
T6899 |
T6896 |
punct |
;,Cre |
R2033 |
T6900 |
T6896 |
compound |
Wnt1,Cre |
R2034 |
T6901 |
T6896 |
punct |
-,Cre |
R2035 |
T6902 |
T6894 |
pobj |
males,with |
R2036 |
T6903 |
T6881 |
punct |
.,crossed |
R2037 |
T6905 |
T6906 |
det |
The,embryos |
R2038 |
T6906 |
T6908 |
nsubj |
embryos,had |
R2039 |
T6907 |
T6906 |
amod |
resulting,embryos |
R2040 |
T6909 |
T6910 |
det |
the,lineage |
R2041 |
T6910 |
T6913 |
nsubj |
lineage,labeled |
R2042 |
T6911 |
T6910 |
compound |
NC,lineage |
R2043 |
T6912 |
T6910 |
punct |
-,lineage |
R2044 |
T6913 |
T6908 |
ccomp |
labeled,had |
R2045 |
T6914 |
T6913 |
advmod |
permanently,labeled |
R2046 |
T6915 |
T6913 |
prep |
with,labeled |
R2047 |
T6916 |
T6917 |
compound |
β,expression |
R2048 |
T6917 |
T6915 |
pobj |
expression,with |
R2049 |
T6918 |
T6917 |
punct |
-,expression |
R2050 |
T6919 |
T6917 |
compound |
galactosidase,expression |
R2051 |
T6920 |
T6908 |
punct |
", ",had |
R2052 |
T6921 |
T6908 |
cc |
and,had |
R2053 |
T6922 |
T6908 |
conj |
displayed,had |
R2054 |
T6923 |
T6924 |
amod |
identical,phenotypes |
R2055 |
T6924 |
T6922 |
dobj |
phenotypes,displayed |
R2056 |
T6925 |
T6924 |
prep |
to,phenotypes |
R2057 |
T6926 |
T6925 |
pobj |
those,to |
R2058 |
T6927 |
T6926 |
acl |
obtained,those |
R2059 |
T6928 |
T6927 |
prep |
without,obtained |
R2060 |
T6929 |
T6930 |
det |
the,reporter |
R2061 |
T6930 |
T6928 |
pobj |
reporter,without |
R2062 |
T6931 |
T6930 |
compound |
R26R,reporter |
R2063 |
T6932 |
T6908 |
punct |
.,had |
R2064 |
T6934 |
T6935 |
nsubj |
Staining,reveal |
R2065 |
T6936 |
T6934 |
prep |
of,Staining |
R2066 |
T6937 |
T6936 |
pobj |
embryos,of |
R2067 |
T6938 |
T6934 |
prep |
for,Staining |
R2068 |
T6939 |
T6940 |
compound |
β,galactosidase |
R2069 |
T6940 |
T6938 |
pobj |
galactosidase,for |
R2070 |
T6941 |
T6940 |
punct |
-,galactosidase |
R2071 |
T6942 |
T6934 |
prep |
at,Staining |
R2072 |
T6943 |
T6942 |
pobj |
E8,at |
R2073 |
T6944 |
T6945 |
punct |
-,E11 |
R2074 |
T6945 |
T6943 |
prep |
E11,E8 |
R2075 |
T6946 |
T6935 |
aux |
did,reveal |
R2076 |
T6947 |
T6935 |
neg |
not,reveal |
R2077 |
T6948 |
T6949 |
amod |
detectable,differences |
R2078 |
T6949 |
T6935 |
dobj |
differences,reveal |
R2079 |
T6950 |
T6949 |
prep |
in,differences |
R2080 |
T6951 |
T6952 |
compound |
NCC,migration |
R2081 |
T6952 |
T6950 |
pobj |
migration,in |
R2082 |
T6953 |
T6949 |
prep |
between,differences |
R2083 |
T6954 |
T6953 |
pobj |
mutants,between |
R2084 |
T6955 |
T6954 |
cc |
and,mutants |
R2085 |
T6956 |
T6954 |
conj |
controls,mutants |
R2086 |
T6957 |
T6958 |
punct |
(,shown |
R2087 |
T6958 |
T6935 |
parataxis |
shown,reveal |
R2088 |
T6959 |
T6958 |
nsubj |
data,shown |
R2089 |
T6960 |
T6958 |
neg |
not,shown |
R2090 |
T6961 |
T6958 |
punct |
),shown |
R2091 |
T6962 |
T6935 |
punct |
.,reveal |
R2092 |
T6964 |
T6965 |
advmod |
Similarly,demonstrated |
R2093 |
T6966 |
T6965 |
punct |
", ",demonstrated |
R2094 |
T6967 |
T6968 |
amod |
serial,sectioning |
R2095 |
T6968 |
T6965 |
nsubj |
sectioning,demonstrated |
R2096 |
T6969 |
T6968 |
amod |
transverse,sectioning |
R2097 |
T6970 |
T6968 |
prep |
of,sectioning |
R2098 |
T6971 |
T6972 |
amod |
whole,mount |
R2099 |
T6972 |
T6973 |
compound |
mount,embryos |
R2100 |
T6973 |
T6970 |
pobj |
embryos,of |
R2101 |
T6974 |
T6975 |
punct |
(,E10 |
R2102 |
T6975 |
T6968 |
parataxis |
E10,sectioning |
R2103 |
T6976 |
T6977 |
punct |
-,E12 |
R2104 |
T6977 |
T6975 |
prep |
E12,E10 |
R2105 |
T6978 |
T6975 |
punct |
),E10 |
R2106 |
T6979 |
T6968 |
cc |
and,sectioning |
R2107 |
T6980 |
T6981 |
amod |
subsequent,analysis |
R2108 |
T6981 |
T6968 |
conj |
analysis,sectioning |
R2109 |
T6982 |
T6981 |
prep |
of,analysis |
R2110 |
T6983 |
T6984 |
advmod |
positively,stained |
R2111 |
T6984 |
T6985 |
amod |
stained,cells |
R2112 |
T6985 |
T6982 |
pobj |
cells,of |
R2113 |
T6986 |
T6985 |
prep |
in,cells |
R2114 |
T6987 |
T6988 |
det |
the,region |
R2115 |
T6988 |
T6986 |
pobj |
region,in |
R2116 |
T6989 |
T6988 |
compound |
OFT,region |
R2117 |
T6990 |
T6991 |
mark |
that,were |
R2118 |
T6991 |
T6965 |
ccomp |
were,demonstrated |
R2119 |
T6992 |
T6991 |
nsubj |
CNCCs,were |
R2120 |
T6993 |
T6992 |
amod |
deficient,CNCCs |
R2121 |
T6994 |
T6993 |
prep |
in,deficient |
R2122 |
T6995 |
T6994 |
pobj |
Alk5,in |
R2123 |
T6996 |
T6991 |
acomp |
capable,were |
R2124 |
T6997 |
T6996 |
prep |
of,capable |
R2125 |
T6998 |
T6997 |
pcomp |
populating,of |
R2126 |
T6999 |
T7000 |
det |
the,PAAs |
R2127 |
T7000 |
T6998 |
dobj |
PAAs,populating |
R2128 |
T7001 |
T7000 |
punct |
", ",PAAs |
R2129 |
T7002 |
T7003 |
amod |
aortic,sac |
R2130 |
T7003 |
T7000 |
conj |
sac,PAAs |
R2131 |
T7004 |
T7003 |
cc |
and,sac |
R2132 |
T7005 |
T7006 |
amod |
conotruncal,ridges |
R2133 |
T7006 |
T7003 |
conj |
ridges,sac |
R2134 |
T7007 |
T6998 |
prep |
at,populating |
R2135 |
T7008 |
T7009 |
det |
a,level |
R2136 |
T7009 |
T7007 |
pobj |
level,at |
R2137 |
T7010 |
T7009 |
amod |
comparable,level |
R2138 |
T7011 |
T7010 |
prep |
to,comparable |
R2139 |
T7012 |
T7011 |
pobj |
that,to |
R2140 |
T7013 |
T7012 |
prep |
of,that |
R2141 |
T7014 |
T7013 |
pobj |
controls,of |
R2142 |
T7015 |
T7016 |
punct |
(,Fig |
R2143 |
T7016 |
T6998 |
parataxis |
Fig,populating |
R2144 |
T7017 |
T7016 |
nummod |
4,Fig |
R2145 |
T7018 |
T7016 |
punct |
),Fig |
R2146 |
T7019 |
T6965 |
punct |
.,demonstrated |
R2147 |
T7021 |
T7022 |
aux |
To,conclude |
R2148 |
T7022 |
T7023 |
advcl |
conclude,were |
R2149 |
T7024 |
T7023 |
punct |
", ",were |
R2150 |
T7025 |
T7026 |
det |
the,phenotypes |
R2151 |
T7026 |
T7023 |
nsubj |
phenotypes,were |
R2152 |
T7027 |
T7026 |
amod |
observed,phenotypes |
R2153 |
T7028 |
T7026 |
prep |
in,phenotypes |
R2154 |
T7029 |
T7030 |
compound |
Alk5,Cre |
R2155 |
T7030 |
T7034 |
compound |
Cre,mutants |
R2156 |
T7031 |
T7030 |
punct |
/,Cre |
R2157 |
T7032 |
T7030 |
compound |
Wnt1,Cre |
R2158 |
T7033 |
T7030 |
punct |
-,Cre |
R2159 |
T7034 |
T7028 |
pobj |
mutants,in |
R2160 |
T7035 |
T7023 |
advmod |
certainly,were |
R2161 |
T7036 |
T7023 |
neg |
not,were |
R2162 |
T7037 |
T7023 |
prep |
due,were |
R2163 |
T7038 |
T7037 |
pcomp |
to,due |
R2164 |
T7039 |
T7040 |
amod |
defective,migration |
R2165 |
T7040 |
T7037 |
pobj |
migration,due |
R2166 |
T7041 |
T7040 |
prep |
of,migration |
R2167 |
T7042 |
T7041 |
pobj |
CNCCs,of |
R2168 |
T7043 |
T7040 |
prep |
to,migration |
R2169 |
T7044 |
T7045 |
det |
the,regions |
R2170 |
T7045 |
T7043 |
pobj |
regions,to |
R2171 |
T7046 |
T7045 |
amod |
pharyngeal,regions |
R2172 |
T7047 |
T7046 |
cc |
and,pharyngeal |
R2173 |
T7048 |
T7049 |
compound |
outflow,tract |
R2174 |
T7049 |
T7046 |
conj |
tract,pharyngeal |
R2175 |
T7050 |
T7023 |
punct |
.,were |
R5751 |
T18898 |
T18899 |
amod |
Normal,migration |
R5752 |
T18900 |
T18899 |
amod |
cardiac,migration |
R5753 |
T18901 |
T18899 |
compound |
NCC,migration |
R5754 |
T18902 |
T18899 |
prep |
in,migration |
R5755 |
T18903 |
T18904 |
compound |
Alk5,Cre |
R5756 |
T18904 |
T18908 |
compound |
Cre,mutants |
R5757 |
T18905 |
T18904 |
punct |
/,Cre |
R5758 |
T18906 |
T18904 |
compound |
Wnt1,Cre |
R5759 |
T18907 |
T18904 |
punct |
-,Cre |
R5760 |
T18908 |
T18902 |
pobj |
mutants,in |
R5761 |
T18909 |
T18899 |
punct |
.,migration |
R5762 |
T18911 |
T18912 |
det |
The,OFT |
R5763 |
T18912 |
T18913 |
nsubj |
OFT,display |
R5764 |
T18914 |
T18912 |
prep |
of,OFT |
R5765 |
T18915 |
T18914 |
pobj |
controls,of |
R5766 |
T18916 |
T18917 |
punct |
(,E |
R5767 |
T18917 |
T18915 |
parataxis |
E,controls |
R5768 |
T18918 |
T18917 |
nmod |
A,E |
R5769 |
T18919 |
T18917 |
punct |
", ",E |
R5770 |
T18920 |
T18917 |
nmod |
C,E |
R5771 |
T18921 |
T18917 |
punct |
", ",E |
R5772 |
T18922 |
T18917 |
punct |
),E |
R5773 |
T18923 |
T18915 |
cc |
and,controls |
R5774 |
T18924 |
T18925 |
compound |
Alk5,Cre |
R5775 |
T18925 |
T18929 |
compound |
Cre,mutants |
R5776 |
T18926 |
T18925 |
punct |
/,Cre |
R5777 |
T18927 |
T18925 |
compound |
Wnt1,Cre |
R5778 |
T18928 |
T18925 |
punct |
-,Cre |
R5779 |
T18929 |
T18915 |
conj |
mutants,controls |
R5780 |
T18930 |
T18931 |
punct |
(,F |
R5781 |
T18931 |
T18929 |
parataxis |
F,mutants |
R5782 |
T18932 |
T18931 |
nmod |
B,F |
R5783 |
T18933 |
T18931 |
punct |
", ",F |
R5784 |
T18934 |
T18931 |
nmod |
D,F |
R5785 |
T18935 |
T18931 |
punct |
", ",F |
R5786 |
T18936 |
T18931 |
punct |
),F |
R5787 |
T18937 |
T18938 |
amod |
similar,patterns |
R5788 |
T18938 |
T18913 |
dobj |
patterns,display |
R5789 |
T18939 |
T18938 |
compound |
staining,patterns |
R5790 |
T18940 |
T18941 |
advmod |
when,analyzed |
R5791 |
T18941 |
T18913 |
advcl |
analyzed,display |
R5792 |
T18942 |
T18941 |
advcl |
using,analyzed |
R5793 |
T18943 |
T18944 |
det |
the,assay |
R5794 |
T18944 |
T18942 |
dobj |
assay,using |
R5795 |
T18945 |
T18944 |
compound |
R26R,assay |
R5796 |
T18946 |
T18947 |
compound |
lineage,tracing |
R5797 |
T18947 |
T18944 |
compound |
tracing,assay |
R5798 |
T18948 |
T18942 |
prep |
at,using |
R5799 |
T18949 |
T18948 |
pobj |
E11.0,at |
R5800 |
T18950 |
T18913 |
punct |
.,display |
R5801 |
T18952 |
T18953 |
meta |
A,staining |
R5802 |
T18954 |
T18952 |
punct |
-,A |
R5803 |
T18955 |
T18952 |
dep |
B,A |
R5804 |
T18956 |
T18953 |
punct |
", ",staining |
R5805 |
T18957 |
T18958 |
amod |
whole,mount |
R5806 |
T18958 |
T18953 |
compound |
mount,staining |
R5807 |
T18959 |
T18960 |
punct |
(,image |
R5808 |
T18960 |
T18953 |
parataxis |
image,staining |
R5809 |
T18961 |
T18960 |
amod |
left,image |
R5810 |
T18962 |
T18960 |
amod |
lateral,image |
R5811 |
T18963 |
T18960 |
punct |
),image |
R5812 |
T18964 |
T18953 |
punct |
;,staining |
R5813 |
T18965 |
T18966 |
meta |
C,sections |
R5814 |
T18966 |
T18953 |
appos |
sections,staining |
R5815 |
T18967 |
T18965 |
punct |
-,C |
R5816 |
T18968 |
T18965 |
dep |
F,C |
R5817 |
T18969 |
T18966 |
punct |
", ",sections |
R5818 |
T18970 |
T18966 |
amod |
transverse,sections |
R5819 |
T18971 |
T18966 |
prep |
on,sections |
R5820 |
T18972 |
T18973 |
det |
the,level |
R5821 |
T18973 |
T18971 |
pobj |
level,on |
R5822 |
T18974 |
T18973 |
prep |
of,level |
R5823 |
T18975 |
T18976 |
det |
the,PAAs |
R5824 |
T18976 |
T18974 |
pobj |
PAAs,of |
R5825 |
T18977 |
T18976 |
amod |
4th,PAAs |
R5826 |
T18978 |
T18979 |
punct |
(,D |
R5827 |
T18979 |
T18977 |
parataxis |
D,4th |
R5828 |
T18980 |
T18979 |
nmod |
C,D |
R5829 |
T18981 |
T18979 |
punct |
", ",D |
R5830 |
T18982 |
T18979 |
punct |
),D |
R5831 |
T18983 |
T18977 |
cc |
and,4th |
R5832 |
T18984 |
T18977 |
conj |
6th,4th |
R5833 |
T18985 |
T18986 |
punct |
(,F |
R5834 |
T18986 |
T18984 |
parataxis |
F,6th |
R5835 |
T18987 |
T18986 |
nmod |
E,F |
R5836 |
T18988 |
T18986 |
punct |
", ",F |
R5837 |
T18989 |
T18986 |
punct |
),F |
R5838 |
T18990 |
T18953 |
punct |
.,staining |
R5839 |
T18992 |
T18993 |
nsubj |
Arrows,point |
R5840 |
T18994 |
T18995 |
punct |
(,A |
R5841 |
T18995 |
T18992 |
parataxis |
A,Arrows |
R5842 |
T18996 |
T18997 |
punct |
-,F |
R5843 |
T18997 |
T18995 |
prep |
F,A |
R5844 |
T18998 |
T18995 |
punct |
),A |
R5845 |
T18999 |
T18993 |
prep |
to,point |
R5846 |
T19000 |
T19001 |
det |
the,location |
R5847 |
T19001 |
T18999 |
pobj |
location,to |
R5848 |
T19002 |
T19003 |
advmod |
most,proximal |
R5849 |
T19003 |
T19001 |
amod |
proximal,location |
R5850 |
T19004 |
T19001 |
acl |
staining,location |
R5851 |
T19005 |
T19004 |
advcl |
positive,staining |
R5852 |
T19006 |
T19005 |
prep |
for,positive |
R5853 |
T19007 |
T19008 |
det |
the,activity |
R5854 |
T19008 |
T19006 |
pobj |
activity,for |
R5855 |
T19009 |
T19010 |
compound |
β,galactosidase |
R5856 |
T19010 |
T19008 |
compound |
galactosidase,activity |
R5857 |
T19011 |
T19010 |
punct |
-,galactosidase |
R5858 |
T19012 |
T18993 |
punct |
.,point |