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PMC:1635039 / 0-849 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T513 0-9 JJ denotes Defective
T515 0-138 sentence denotes Defective ALK5 signaling in the neural crest leads to increased postmigratory neural crest cell apoptosis and severe outflow tract defects
T516 10-14 NN denotes ALK5
T514 15-24 NN denotes signaling
T518 25-27 IN denotes in
T519 28-31 DT denotes the
T521 32-38 JJ denotes neural
T520 39-44 NN denotes crest
T517 45-50 VBZ denotes leads
T522 51-53 IN denotes to
T523 54-63 VBN denotes increased
T525 64-77 JJ denotes postmigratory
T526 78-84 JJ denotes neural
T528 85-90 NN denotes crest
T527 91-95 NN denotes cell
T524 96-105 NN denotes apoptosis
T529 106-109 CC denotes and
T530 110-116 JJ denotes severe
T532 117-124 NN denotes outflow
T533 125-130 NN denotes tract
T531 131-138 NNS denotes defects
T534 138-139 sentence denotes
T535 149-159 sentence denotes Background
T536 149-159 NN denotes Background
T537 159-247 sentence denotes Congenital cardiovascular diseases are the most common form of birth defects in humans.
T538 160-170 JJ denotes Congenital
T540 171-185 JJ denotes cardiovascular
T539 186-194 NNS denotes diseases
T541 195-198 VBP denotes are
T542 199-202 DT denotes the
T544 203-207 RBS denotes most
T545 208-214 JJ denotes common
T543 215-219 NN denotes form
T546 220-222 IN denotes of
T547 223-228 NN denotes birth
T548 229-236 NNS denotes defects
T549 237-239 IN denotes in
T550 240-246 NNS denotes humans
T551 246-247 . denotes .
T552 247-426 sentence denotes A substantial portion of these defects has been associated with inappropriate induction, migration, differentiation and patterning of pluripotent cardiac neural crest stem cells.
T553 248-249 DT denotes A
T555 250-261 JJ denotes substantial
T554 262-269 NN denotes portion
T557 270-272 IN denotes of
T558 273-278 DT denotes these
T559 279-286 NNS denotes defects
T560 287-290 VBZ denotes has
T561 291-295 VBN denotes been
T556 296-306 VBN denotes associated
T562 307-311 IN denotes with
T563 312-325 JJ denotes inappropriate
T564 326-335 NN denotes induction
T565 335-337 , denotes ,
T566 337-346 NN denotes migration
T567 346-348 , denotes ,
T568 348-363 NN denotes differentiation
T569 364-367 CC denotes and
T570 368-378 NN denotes patterning
T571 379-381 IN denotes of
T572 382-393 JJ denotes pluripotent
T574 394-401 JJ denotes cardiac
T576 402-408 JJ denotes neural
T575 409-414 NN denotes crest
T577 415-419 NN denotes stem
T573 420-425 NNS denotes cells
T578 425-426 . denotes .
T579 426-604 sentence denotes While TGF-β-superfamily signaling has been strongly implicated in neural crest cell development, the detailed molecular signaling mechanisms in vivo are still poorly understood.
T580 427-432 IN denotes While
T582 433-436 NN denotes TGF
T584 436-437 HYPH denotes -
T583 437-438 NN denotes β
T586 438-439 HYPH denotes -
T585 439-450 NN denotes superfamily
T587 451-460 NN denotes signaling
T588 461-464 VBZ denotes has
T589 465-469 VBN denotes been
T590 470-478 RB denotes strongly
T581 479-489 VBN denotes implicated
T592 490-492 IN denotes in
T593 493-499 JJ denotes neural
T595 500-505 NN denotes crest
T594 506-510 NN denotes cell
T596 511-522 NN denotes development
T597 522-524 , denotes ,
T598 524-527 DT denotes the
T600 528-536 JJ denotes detailed
T601 537-546 JJ denotes molecular
T602 547-556 NN denotes signaling
T599 557-567 NNS denotes mechanisms
T603 568-570 FW denotes in
T604 571-575 FW denotes vivo
T605 576-579 VBP denotes are
T606 580-585 RB denotes still
T607 586-592 RB denotes poorly
T591 593-603 VBN denotes understood
T608 603-604 . denotes .
T609 604-613 sentence denotes Results
T610 606-613 NNS denotes Results
T611 613-708 sentence denotes We deleted the TGF-β type I receptor Alk5 specifically in the mouse neural crest cell lineage.
T612 614-616 PRP denotes We
T613 617-624 VBD denotes deleted
T614 625-628 DT denotes the
T616 629-632 NN denotes TGF
T618 632-633 HYPH denotes -
T617 633-634 NN denotes β
T619 635-639 NN denotes type
T620 640-641 CD denotes I
T621 642-650 NN denotes receptor
T615 651-655 NN denotes Alk5
T622 656-668 RB denotes specifically
T623 669-671 IN denotes in
T624 672-675 DT denotes the
T626 676-681 NN denotes mouse
T627 682-688 JJ denotes neural
T629 689-694 NN denotes crest
T628 695-699 NN denotes cell
T625 700-707 NN denotes lineage
T630 707-708 . denotes .
T632 709-716 NN denotes Failure
T634 717-719 IN denotes in
T635 720-729 NN denotes signaling
T636 730-733 IN denotes via
T637 734-738 NN denotes ALK5
T633 739-744 VBZ denotes leads
T638 745-747 IN denotes to
T639 748-754 JJ denotes severe
T641 755-769 JJ denotes cardiovascular
T642 770-773 CC denotes and
T643 774-784 JJ denotes pharyngeal
T640 785-792 NNS denotes defects
T644 792-794 , denotes ,
T645 794-803 VBG denotes including
T646 804-817 JJ denotes inappropriate
T647 818-828 NN denotes remodeling
T648 829-831 IN denotes of
T649 832-842 JJ denotes pharyngeal
T651 843-847 NN denotes arch
R100 T612 T613 nsubj We,deleted
R101 T614 T615 det the,Alk5
R102 T615 T613 dobj Alk5,deleted
R103 T616 T617 nmod TGF,β
R104 T617 T615 nmod β,Alk5
R105 T618 T617 punct -,β
R106 T619 T615 nmod type,Alk5
R107 T620 T619 nummod I,type
R108 T621 T615 compound receptor,Alk5
R109 T622 T613 advmod specifically,deleted
R110 T623 T613 prep in,deleted
R111 T624 T625 det the,lineage
R112 T625 T623 pobj lineage,in
R113 T626 T625 nmod mouse,lineage
R114 T627 T628 amod neural,cell
R115 T628 T625 compound cell,lineage
R116 T629 T628 compound crest,cell
R117 T630 T613 punct .,deleted
R118 T632 T633 nsubj Failure,leads
R119 T634 T632 prep in,Failure
R120 T635 T634 pobj signaling,in
R121 T636 T632 prep via,Failure
R122 T637 T636 pobj ALK5,via
R123 T638 T633 prep to,leads
R124 T639 T640 amod severe,defects
R125 T640 T638 pobj defects,to
R126 T641 T640 amod cardiovascular,defects
R127 T642 T641 cc and,cardiovascular
R128 T643 T641 conj pharyngeal,cardiovascular
R129 T644 T640 punct ", ",defects
R130 T645 T640 prep including,defects
R131 T646 T647 amod inappropriate,remodeling
R132 T647 T645 pobj remodeling,including
R133 T648 T647 prep of,remodeling
R16 T514 T517 nsubj signaling,leads
R17 T516 T514 compound ALK5,signaling
R18 T518 T514 prep in,signaling
R19 T519 T520 det the,crest
R20 T520 T518 pobj crest,in
R209 T513 T514 amod Defective,signaling
R21 T521 T520 amod neural,crest
R22 T522 T517 prep to,leads
R23 T523 T524 amod increased,apoptosis
R24 T524 T522 pobj apoptosis,to
R25 T525 T524 amod postmigratory,apoptosis
R26 T526 T527 amod neural,cell
R27 T527 T524 compound cell,apoptosis
R28 T528 T527 compound crest,cell
R29 T529 T524 cc and,apoptosis
R30 T530 T531 amod severe,defects
R31 T531 T524 conj defects,apoptosis
R32 T532 T533 compound outflow,tract
R33 T533 T531 compound tract,defects
R34 T538 T539 amod Congenital,diseases
R35 T539 T541 nsubj diseases,are
R36 T540 T539 amod cardiovascular,diseases
R37 T542 T543 det the,form
R38 T543 T541 attr form,are
R39 T544 T545 advmod most,common
R40 T545 T543 amod common,form
R41 T546 T543 prep of,form
R42 T547 T548 compound birth,defects
R43 T548 T546 pobj defects,of
R44 T549 T543 prep in,form
R45 T550 T549 pobj humans,in
R46 T551 T541 punct .,are
R47 T553 T554 det A,portion
R48 T554 T556 nsubjpass portion,associated
R49 T555 T554 amod substantial,portion
R50 T557 T554 prep of,portion
R51 T558 T559 det these,defects
R52 T559 T557 pobj defects,of
R53 T560 T556 aux has,associated
R54 T561 T556 auxpass been,associated
R55 T562 T556 prep with,associated
R56 T563 T564 amod inappropriate,induction
R57 T564 T562 pobj induction,with
R58 T565 T564 punct ", ",induction
R59 T566 T564 conj migration,induction
R60 T567 T566 punct ", ",migration
R61 T568 T566 conj differentiation,migration
R62 T569 T568 cc and,differentiation
R63 T570 T568 conj patterning,differentiation
R64 T571 T564 prep of,induction
R65 T572 T573 amod pluripotent,cells
R66 T573 T571 pobj cells,of
R67 T574 T575 amod cardiac,crest
R68 T575 T573 compound crest,cells
R69 T576 T575 amod neural,crest
R70 T577 T573 compound stem,cells
R71 T578 T556 punct .,associated
R72 T580 T581 mark While,implicated
R73 T581 T591 advcl implicated,understood
R74 T582 T583 compound TGF,β
R75 T583 T585 compound β,superfamily
R76 T584 T583 punct -,β
R77 T585 T587 compound superfamily,signaling
R78 T586 T585 punct -,superfamily
R79 T587 T581 nsubjpass signaling,implicated
R80 T588 T581 aux has,implicated
R81 T589 T581 auxpass been,implicated
R82 T590 T581 advmod strongly,implicated
R83 T592 T581 prep in,implicated
R84 T593 T594 amod neural,cell
R85 T594 T596 compound cell,development
R86 T595 T594 compound crest,cell
R87 T596 T592 pobj development,in
R88 T597 T591 punct ", ",understood
R89 T598 T599 det the,mechanisms
R90 T599 T591 nsubjpass mechanisms,understood
R91 T600 T599 amod detailed,mechanisms
R92 T601 T599 amod molecular,mechanisms
R93 T602 T599 compound signaling,mechanisms
R94 T603 T604 advmod in,vivo
R95 T604 T599 advmod vivo,mechanisms
R96 T605 T591 auxpass are,understood
R97 T606 T591 advmod still,understood
R98 T607 T591 advmod poorly,understood
R99 T608 T591 punct .,understood