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PMC:1630711 / 3237-5819 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE-old TextAE

Id Subject Object Predicate Lexical cue
T2297 0-6 IN denotes During
T2299 7-12 NN denotes mouse
T2301 13-29 NN denotes pre-implantation
T2300 30-41 NN denotes development
T2302 41-43 , denotes ,
T2303 43-46 DT denotes the
T2304 47-53 NN denotes genome
T2298 54-63 VBZ denotes undergoes
T2305 64-65 DT denotes a
T2306 66-72 NN denotes series
T2307 73-75 IN denotes of
T2308 76-81 JJ denotes major
T2310 82-92 JJ denotes epigenetic
T2309 93-100 NNS denotes changes
T2311 101-109 VBN denotes required
T2312 110-113 IN denotes for
T2313 114-123 JJ denotes embryonic
T2315 124-128 NN denotes gene
T2314 129-139 NN denotes expression
T2316 139-141 , denotes ,
T2317 141-144 DT denotes the
T2318 145-156 NN denotes maintenance
T2319 157-159 IN denotes of
T2320 160-171 NN denotes totipotency
T2321 171-173 , denotes ,
T2322 173-176 CC denotes and
T2323 177-180 DT denotes the
T2325 181-186 JJ denotes first
T2326 187-202 NN denotes differentiation
T2324 203-209 NNS denotes events
T2327 210-211 -LRB- denotes [
T2329 211-212 CD denotes 1
T2330 212-213 , denotes ,
T2328 213-214 CD denotes 2
T2331 214-215 -RRB- denotes ]
T2332 215-216 . denotes .
T2333 216-387 sentence denotes While many studies have established the importance of DNA methylation in epigenetic reprogramming, recent data point to a crucial role of chromatin in this process [3–5].
T2334 217-222 IN denotes While
T2336 223-227 JJ denotes many
T2337 228-235 NNS denotes studies
T2338 236-240 VBP denotes have
T2335 241-252 VBN denotes established
T2340 253-256 DT denotes the
T2341 257-267 NN denotes importance
T2342 268-270 IN denotes of
T2343 271-274 NN denotes DNA
T2344 275-286 NN denotes methylation
T2345 287-289 IN denotes in
T2346 290-300 JJ denotes epigenetic
T2347 301-314 NN denotes reprogramming
T2348 314-316 , denotes ,
T2349 316-322 JJ denotes recent
T2350 323-327 NNS denotes data
T2339 328-333 VBP denotes point
T2351 334-336 IN denotes to
T2352 337-338 DT denotes a
T2354 339-346 JJ denotes crucial
T2353 347-351 NN denotes role
T2355 352-354 IN denotes of
T2356 355-364 NN denotes chromatin
T2357 365-367 IN denotes in
T2358 368-372 DT denotes this
T2359 373-380 NN denotes process
T2360 381-382 -LRB- denotes [
T2361 382-383 CD denotes 3
T2362 383-384 SYM denotes –
T2363 384-385 CD denotes 5
T2364 385-386 -RRB- denotes ]
T2365 386-387 . denotes .
T2366 387-595 sentence denotes Yet we know very little about the role of histone modifying enzymes, chromatin remodeling factors, and histone chaperones during pre-implantation development, or in stem cells derived from early embryos [6].
T2367 388-391 RB denotes Yet
T2369 392-394 PRP denotes we
T2368 395-399 VBP denotes know
T2370 400-404 RB denotes very
T2371 405-411 JJ denotes little
T2372 412-417 IN denotes about
T2373 418-421 DT denotes the
T2374 422-426 NN denotes role
T2375 427-429 IN denotes of
T2376 430-437 NN denotes histone
T2377 438-447 VBG denotes modifying
T2378 448-455 NNS denotes enzymes
T2379 455-457 , denotes ,
T2380 457-466 NN denotes chromatin
T2381 467-477 NN denotes remodeling
T2382 478-485 NNS denotes factors
T2383 485-487 , denotes ,
T2384 487-490 CC denotes and
T2385 491-498 NN denotes histone
T2386 499-509 NNS denotes chaperones
T2387 510-516 IN denotes during
T2388 517-533 NN denotes pre-implantation
T2389 534-545 NN denotes development
T2390 545-547 , denotes ,
T2391 547-549 CC denotes or
T2392 550-552 IN denotes in
T2393 553-557 NN denotes stem
T2394 558-563 NNS denotes cells
T2395 564-571 VBN denotes derived
T2396 572-576 IN denotes from
T2397 577-582 JJ denotes early
T2398 583-590 NNS denotes embryos
T2399 591-592 -LRB- denotes [
T2400 592-593 CD denotes 6
T2401 593-594 -RRB- denotes ]
T2402 594-595 . denotes .
T2403 595-841 sentence denotes A subset of identified histone chaperones and chromatin remodeling complexes can collaborate to promote nucleosome assembly in vitro and are therefore in a strategic position to control chromatin assembly and maturation during development [7,8].
T2404 596-597 DT denotes A
T2405 598-604 NN denotes subset
T2407 605-607 IN denotes of
T2408 608-618 VBN denotes identified
T2410 619-626 NN denotes histone
T2409 627-637 NNS denotes chaperones
T2411 638-641 CC denotes and
T2412 642-651 NN denotes chromatin
T2413 652-662 NN denotes remodeling
T2414 663-672 NNS denotes complexes
T2415 673-676 MD denotes can
T2406 677-688 VB denotes collaborate
T2416 689-691 TO denotes to
T2417 692-699 VB denotes promote
T2418 700-710 NN denotes nucleosome
T2419 711-719 NN denotes assembly
T2420 720-722 FW denotes in
T2421 723-728 FW denotes vitro
T2422 729-732 CC denotes and
T2423 733-736 VBP denotes are
T2424 737-746 RB denotes therefore
T2425 747-749 IN denotes in
T2426 750-751 DT denotes a
T2428 752-761 JJ denotes strategic
T2427 762-770 NN denotes position
T2429 771-773 TO denotes to
T2430 774-781 VB denotes control
T2431 782-791 NN denotes chromatin
T2432 792-800 NN denotes assembly
T2433 801-804 CC denotes and
T2434 805-815 NN denotes maturation
T2435 816-822 IN denotes during
T2436 823-834 NN denotes development
T2437 835-836 -LRB- denotes [
T2439 836-837 CD denotes 7
T2440 837-838 , denotes ,
T2438 838-839 CD denotes 8
T2441 839-840 -RRB- denotes ]
T2442 840-841 . denotes .
T2443 841-1063 sentence denotes Among histone chaperones, chromatin assembly factor 1 (CAF-1) is a three-subunit (p150, p60, and p48) complex which promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair [9,10].
T2444 842-847 IN denotes Among
T2446 848-855 NN denotes histone
T2447 856-866 NNS denotes chaperones
T2448 866-868 , denotes ,
T2449 868-877 NN denotes chromatin
T2450 878-886 NN denotes assembly
T2451 887-893 NN denotes factor
T2452 894-895 CD denotes 1
T2453 896-897 -LRB- denotes (
T2454 897-900 NN denotes CAF
T2455 900-901 HYPH denotes -
T2456 901-902 CD denotes 1
T2457 902-903 -RRB- denotes )
T2445 904-906 VBZ denotes is
T2458 907-908 DT denotes a
T2460 909-914 CD denotes three
T2462 914-915 HYPH denotes -
T2461 915-922 NN denotes subunit
T2463 923-924 -LRB- denotes (
T2464 924-928 NN denotes p150
T2465 928-930 , denotes ,
T2466 930-933 NN denotes p60
T2467 933-935 , denotes ,
T2468 935-938 CC denotes and
T2469 939-942 NN denotes p48
T2470 942-943 -RRB- denotes )
T2459 944-951 NN denotes complex
T2471 952-957 WDT denotes which
T2472 958-966 VBZ denotes promotes
T2473 967-974 NN denotes histone
T2474 975-977 NN denotes H3
T2476 978-981 CC denotes and
T2477 982-984 NN denotes H4
T2475 985-995 NN denotes deposition
T2478 996-1000 IN denotes onto
T2479 1001-1006 RB denotes newly
T2480 1007-1018 VBN denotes synthesized
T2481 1019-1022 NN denotes DNA
T2482 1023-1029 IN denotes during
T2483 1030-1041 NN denotes replication
T2484 1042-1044 CC denotes or
T2485 1045-1048 NN denotes DNA
T2486 1049-1055 NN denotes repair
T2487 1056-1057 -LRB- denotes [
T2489 1057-1058 CD denotes 9
T2490 1058-1059 , denotes ,
T2488 1059-1061 CD denotes 10
T2491 1061-1062 -RRB- denotes ]
T2492 1062-1063 . denotes .
T2493 1063-1315 sentence denotes Specifically, CAF-1 deposits the histone H3 variant H3.1 into chromatin, in a pathway coupled to DNA synthesis, whereas a second histone chaperone, HIRA, is involved in the deposition of the H3.3 variant in a DNA synthesis independent pathway [11,12].
T2494 1064-1076 RB denotes Specifically
T2496 1076-1078 , denotes ,
T2497 1078-1081 NN denotes CAF
T2498 1081-1082 HYPH denotes -
T2499 1082-1083 CD denotes 1
T2495 1084-1092 VBZ denotes deposits
T2500 1093-1096 DT denotes the
T2502 1097-1104 NN denotes histone
T2503 1105-1107 NN denotes H3
T2501 1108-1115 NN denotes variant
T2504 1116-1120 NN denotes H3.1
T2505 1121-1125 IN denotes into
T2506 1126-1135 NN denotes chromatin
T2507 1135-1137 , denotes ,
T2508 1137-1139 IN denotes in
T2509 1140-1141 DT denotes a
T2510 1142-1149 NN denotes pathway
T2511 1150-1157 VBN denotes coupled
T2512 1158-1160 IN denotes to
T2513 1161-1164 NN denotes DNA
T2514 1165-1174 NN denotes synthesis
T2515 1174-1176 , denotes ,
T2516 1176-1183 IN denotes whereas
T2518 1184-1185 DT denotes a
T2520 1186-1192 JJ denotes second
T2521 1193-1200 NN denotes histone
T2519 1201-1210 NN denotes chaperone
T2522 1210-1212 , denotes ,
T2523 1212-1216 NN denotes HIRA
T2524 1216-1218 , denotes ,
T2525 1218-1220 VBZ denotes is
T2517 1221-1229 VBN denotes involved
T2526 1230-1232 IN denotes in
T2527 1233-1236 DT denotes the
T2528 1237-1247 NN denotes deposition
T2529 1248-1250 IN denotes of
T2530 1251-1254 DT denotes the
T2532 1255-1259 NN denotes H3.3
T2531 1260-1267 NN denotes variant
T2533 1268-1270 IN denotes in
T2534 1271-1272 DT denotes a
T2536 1273-1276 NN denotes DNA
T2537 1277-1286 NN denotes synthesis
T2538 1287-1298 JJ denotes independent
T2535 1299-1306 NN denotes pathway
T2539 1307-1308 -LRB- denotes [
T2541 1308-1310 CD denotes 11
T2542 1310-1311 , denotes ,
T2540 1311-1313 CD denotes 12
T2543 1313-1314 -RRB- denotes ]
T2544 1314-1315 . denotes .
T2545 1315-1622 sentence denotes In addition to this specific chromatin assembly activity, CAF-1 interacts with several proteins present in heterochromatin, including heterochromatin protein 1 (HP1) and MBD1, a methyl-CpG binding domain protein that recruits histone deacetylase and repressive histone methyltransferase activities [13–15].
T2546 1316-1318 IN denotes In
T2548 1319-1327 NN denotes addition
T2549 1328-1330 IN denotes to
T2550 1331-1335 DT denotes this
T2552 1336-1344 JJ denotes specific
T2553 1345-1354 NN denotes chromatin
T2554 1355-1363 NN denotes assembly
T2551 1364-1372 NN denotes activity
T2555 1372-1374 , denotes ,
T2556 1374-1377 NN denotes CAF
T2557 1377-1378 HYPH denotes -
T2558 1378-1379 CD denotes 1
T2547 1380-1389 VBZ denotes interacts
T2559 1390-1394 IN denotes with
T2560 1395-1402 JJ denotes several
T2561 1403-1411 NN denotes proteins
T2562 1412-1419 JJ denotes present
T2563 1420-1422 IN denotes in
T2564 1423-1438 NN denotes heterochromatin
T2565 1438-1440 , denotes ,
T2566 1440-1449 VBG denotes including
T2567 1450-1465 NN denotes heterochromatin
T2568 1466-1473 NN denotes protein
T2569 1474-1475 CD denotes 1
T2570 1476-1477 -LRB- denotes (
T2571 1477-1480 NN denotes HP1
T2572 1480-1481 -RRB- denotes )
T2573 1482-1485 CC denotes and
T2574 1486-1490 NN denotes MBD1
T2575 1490-1492 , denotes ,
T2576 1492-1493 DT denotes a
T2578 1494-1500 NN denotes methyl
T2580 1500-1501 HYPH denotes -
T2579 1501-1504 NN denotes CpG
T2581 1505-1512 NN denotes binding
T2582 1513-1519 NN denotes domain
T2577 1520-1527 NN denotes protein
T2583 1528-1532 WDT denotes that
T2584 1533-1541 VBZ denotes recruits
T2585 1542-1549 NN denotes histone
T2586 1550-1561 NN denotes deacetylase
T2588 1562-1565 CC denotes and
T2589 1566-1576 JJ denotes repressive
T2591 1577-1584 NN denotes histone
T2590 1585-1602 NN denotes methyltransferase
T2587 1603-1613 NNS denotes activities
T2592 1614-1615 -LRB- denotes [
T2593 1615-1617 CD denotes 13
T2594 1617-1618 SYM denotes –
T2595 1618-1620 CD denotes 15
T2596 1620-1621 -RRB- denotes ]
T2597 1621-1622 . denotes .
T2598 1622-1794 sentence denotes Furthermore, p150CAF-1 is required to ensure a replication-specific pool of HP1 molecules at replication sites in pericentric heterochromatin during mid-late S phase [16].
T2599 1623-1634 RB denotes Furthermore
T2601 1634-1636 , denotes ,
T2602 1636-1643 NN denotes p150CAF
T2603 1643-1644 HYPH denotes -
T2604 1644-1645 CD denotes 1
T2605 1646-1648 VBZ denotes is
T2600 1649-1657 VBN denotes required
T2606 1658-1660 TO denotes to
T2607 1661-1667 VB denotes ensure
T2608 1668-1669 DT denotes a
T2610 1670-1681 NN denotes replication
T2612 1681-1682 HYPH denotes -
T2611 1682-1690 JJ denotes specific
T2609 1691-1695 NN denotes pool
T2613 1696-1698 IN denotes of
T2614 1699-1702 NN denotes HP1
T2615 1703-1712 NNS denotes molecules
T2616 1713-1715 IN denotes at
T2617 1716-1727 NN denotes replication
T2618 1728-1733 NNS denotes sites
T2619 1734-1736 IN denotes in
T2620 1737-1748 JJ denotes pericentric
T2621 1749-1764 NN denotes heterochromatin
T2622 1765-1771 IN denotes during
T2623 1772-1775 JJ denotes mid
T2625 1775-1776 SYM denotes -
T2624 1776-1780 JJ denotes late
T2627 1781-1782 NN denotes S
T2626 1783-1788 NN denotes phase
T2628 1789-1790 -LRB- denotes [
T2629 1790-1792 CD denotes 16
T2630 1792-1793 -RRB- denotes ]
T2631 1793-1794 . denotes .
T2632 1794-1927 sentence denotes Taken together, these data suggest roles for CAF-1 in the formation of heterochromatin and in the heritability of epigenetic traits.
T2633 1795-1800 VBN denotes Taken
T2635 1801-1809 RB denotes together
T2636 1809-1811 , denotes ,
T2637 1811-1816 DT denotes these
T2638 1817-1821 NNS denotes data
T2634 1822-1829 VBP denotes suggest
T2639 1830-1835 NNS denotes roles
T2640 1836-1839 IN denotes for
T2641 1840-1843 NN denotes CAF
T2642 1843-1844 HYPH denotes -
T2643 1844-1845 CD denotes 1
T2644 1846-1848 IN denotes in
T2645 1849-1852 DT denotes the
T2646 1853-1862 NN denotes formation
T2647 1863-1865 IN denotes of
T2648 1866-1881 NN denotes heterochromatin
T2649 1882-1885 CC denotes and
T2650 1886-1888 IN denotes in
T2651 1889-1892 DT denotes the
T2652 1893-1905 NN denotes heritability
T2653 1906-1908 IN denotes of
T2654 1909-1919 JJ denotes epigenetic
T2655 1920-1926 NNS denotes traits
T2656 1926-1927 . denotes .
T2657 1927-2187 sentence denotes While the function of this evolutionary conserved histone chaperone has been studied extensively biochemically, we still lack information concerning its importance during early development in mammals and in pluripotent cells such as embryonic stem (ES) cells.
T2658 1928-1933 IN denotes While
T2660 1934-1937 DT denotes the
T2661 1938-1946 NN denotes function
T2662 1947-1949 IN denotes of
T2663 1950-1954 DT denotes this
T2665 1955-1967 JJ denotes evolutionary
T2666 1968-1977 VBN denotes conserved
T2667 1978-1985 NN denotes histone
T2664 1986-1995 NN denotes chaperone
T2668 1996-1999 VBZ denotes has
T2669 2000-2004 VBN denotes been
T2659 2005-2012 VBN denotes studied
T2671 2013-2024 RB denotes extensively
T2672 2025-2038 RB denotes biochemically
T2673 2038-2040 , denotes ,
T2674 2040-2042 PRP denotes we
T2675 2043-2048 RB denotes still
T2670 2049-2053 VBP denotes lack
T2676 2054-2065 NN denotes information
T2677 2066-2076 VBG denotes concerning
T2678 2077-2080 PRP$ denotes its
T2679 2081-2091 NN denotes importance
T2680 2092-2098 IN denotes during
T2681 2099-2104 JJ denotes early
T2682 2105-2116 NN denotes development
T2683 2117-2119 IN denotes in
T2684 2120-2127 NNS denotes mammals
T2685 2128-2131 CC denotes and
T2686 2132-2134 IN denotes in
T2687 2135-2146 JJ denotes pluripotent
T2688 2147-2152 NNS denotes cells
T2689 2153-2157 JJ denotes such
T2690 2158-2160 IN denotes as
T2691 2161-2170 JJ denotes embryonic
T2692 2171-2175 NN denotes stem
T2694 2176-2177 -LRB- denotes (
T2695 2177-2179 NN denotes ES
T2696 2179-2180 -RRB- denotes )
T2693 2181-2186 NNS denotes cells
T2697 2186-2187 . denotes .
T2698 2187-2345 sentence denotes Here, we have analyzed the importance of CAF-1 during early mouse development by genetic ablation and in ES cells by depletion using RNA interference (RNAi).
T2699 2188-2192 RB denotes Here
T2701 2192-2194 , denotes ,
T2702 2194-2196 PRP denotes we
T2703 2197-2201 VBP denotes have
T2700 2202-2210 VBN denotes analyzed
T2704 2211-2214 DT denotes the
T2705 2215-2225 NN denotes importance
T2706 2226-2228 IN denotes of
T2707 2229-2232 NN denotes CAF
T2708 2232-2233 HYPH denotes -
T2709 2233-2234 CD denotes 1
T2710 2235-2241 IN denotes during
T2711 2242-2247 JJ denotes early
T2713 2248-2253 NN denotes mouse
T2712 2254-2265 NN denotes development
T2714 2266-2268 IN denotes by
T2715 2269-2276 JJ denotes genetic
T2716 2277-2285 NN denotes ablation
T2717 2286-2289 CC denotes and
T2718 2290-2292 IN denotes in
T2719 2293-2295 NN denotes ES
T2720 2296-2301 NNS denotes cells
T2721 2302-2304 IN denotes by
T2722 2305-2314 NN denotes depletion
T2723 2315-2320 VBG denotes using
T2724 2321-2324 NN denotes RNA
T2725 2325-2337 NN denotes interference
T2726 2338-2339 -LRB- denotes (
T2727 2339-2343 NN denotes RNAi
T2728 2343-2344 -RRB- denotes )
T2729 2344-2345 . denotes .
T2730 2345-2428 sentence denotes We show that CAF-1 is essential for viability in early mouse embryos and ES cells.
T2731 2346-2348 PRP denotes We
T2732 2349-2353 VBP denotes show
T2733 2354-2358 IN denotes that
T2735 2359-2362 NN denotes CAF
T2736 2362-2363 HYPH denotes -
T2737 2363-2364 CD denotes 1
T2734 2365-2367 VBZ denotes is
T2738 2368-2377 JJ denotes essential
T2739 2378-2381 IN denotes for
T2740 2382-2391 NN denotes viability
T2741 2392-2394 IN denotes in
T2742 2395-2400 JJ denotes early
T2744 2401-2406 NN denotes mouse
T2743 2407-2414 NNS denotes embryos
T2745 2415-2418 CC denotes and
T2746 2419-2421 NN denotes ES
T2747 2422-2427 NNS denotes cells
T2748 2427-2428 . denotes .
T2749 2428-2582 sentence denotes We provide evidence that CAF-1 is required for the spatial organization and epigenetic marking of heterochromatin domains in pluripotent embryonic cells.
T2750 2429-2431 PRP denotes We
T2751 2432-2439 VBP denotes provide
T2752 2440-2448 NN denotes evidence
T2753 2449-2453 IN denotes that
T2755 2454-2457 NN denotes CAF
T2756 2457-2458 HYPH denotes -
T2757 2458-2459 CD denotes 1
T2758 2460-2462 VBZ denotes is
T2754 2463-2471 VBN denotes required
T2759 2472-2475 IN denotes for
T2760 2476-2479 DT denotes the
T2762 2480-2487 JJ denotes spatial
T2761 2488-2500 NN denotes organization
T2763 2501-2504 CC denotes and
T2764 2505-2515 JJ denotes epigenetic
T2765 2516-2523 NN denotes marking
T2766 2524-2526 IN denotes of
T2767 2527-2542 NN denotes heterochromatin
T2768 2543-2550 NNS denotes domains
T2769 2551-2553 IN denotes in
T2770 2554-2565 JJ denotes pluripotent
T2772 2566-2575 JJ denotes embryonic
T2771 2576-2581 NNS denotes cells
T2773 2581-2582 . denotes .
R330 T2297 T2298 prep During,undergoes
R331 T2299 T2300 compound mouse,development
R332 T2300 T2297 pobj development,During
R333 T2301 T2300 compound pre-implantation,development
R334 T2302 T2298 punct ", ",undergoes
R335 T2303 T2304 det the,genome
R336 T2304 T2298 nsubj genome,undergoes
R337 T2305 T2306 det a,series
R338 T2306 T2298 dobj series,undergoes
R339 T2307 T2306 prep of,series
R340 T2308 T2309 amod major,changes
R341 T2309 T2307 pobj changes,of
R342 T2310 T2309 amod epigenetic,changes
R343 T2311 T2309 acl required,changes
R344 T2312 T2311 prep for,required
R345 T2313 T2314 amod embryonic,expression
R346 T2314 T2312 pobj expression,for
R347 T2315 T2314 compound gene,expression
R348 T2316 T2314 punct ", ",expression
R349 T2317 T2318 det the,maintenance
R350 T2318 T2314 conj maintenance,expression
R351 T2319 T2318 prep of,maintenance
R352 T2320 T2319 pobj totipotency,of
R353 T2321 T2318 punct ", ",maintenance
R354 T2322 T2318 cc and,maintenance
R355 T2323 T2324 det the,events
R356 T2324 T2318 conj events,maintenance
R357 T2325 T2324 amod first,events
R358 T2326 T2324 compound differentiation,events
R359 T2327 T2328 punct [,2
R360 T2328 T2298 parataxis 2,undergoes
R361 T2329 T2328 nummod 1,2
R362 T2330 T2328 punct ",",2
R363 T2331 T2328 punct ],2
R364 T2332 T2298 punct .,undergoes
R365 T2334 T2335 mark While,established
R366 T2335 T2339 advcl established,point
R367 T2336 T2337 amod many,studies
R368 T2337 T2335 nsubj studies,established
R369 T2338 T2335 aux have,established
R370 T2340 T2341 det the,importance
R371 T2341 T2335 dobj importance,established
R372 T2342 T2341 prep of,importance
R373 T2343 T2344 compound DNA,methylation
R374 T2344 T2342 pobj methylation,of
R375 T2345 T2341 prep in,importance
R376 T2346 T2347 amod epigenetic,reprogramming
R377 T2347 T2345 pobj reprogramming,in
R378 T2348 T2339 punct ", ",point
R379 T2349 T2350 amod recent,data
R380 T2350 T2339 nsubj data,point
R381 T2351 T2339 prep to,point
R382 T2352 T2353 det a,role
R383 T2353 T2351 pobj role,to
R384 T2354 T2353 amod crucial,role
R385 T2355 T2353 prep of,role
R386 T2356 T2355 pobj chromatin,of
R387 T2357 T2353 prep in,role
R388 T2358 T2359 det this,process
R389 T2359 T2357 pobj process,in
R390 T2360 T2361 punct [,3
R391 T2361 T2339 parataxis 3,point
R392 T2362 T2363 punct –,5
R393 T2363 T2361 prep 5,3
R394 T2364 T2361 punct ],3
R395 T2365 T2339 punct .,point
R396 T2367 T2368 advmod Yet,know
R397 T2369 T2368 nsubj we,know
R398 T2370 T2371 advmod very,little
R399 T2371 T2368 dobj little,know
R400 T2372 T2371 prep about,little
R401 T2373 T2374 det the,role
R402 T2374 T2372 pobj role,about
R403 T2375 T2374 prep of,role
R404 T2376 T2377 npadvmod histone,modifying
R405 T2377 T2378 amod modifying,enzymes
R406 T2378 T2375 pobj enzymes,of
R407 T2379 T2378 punct ", ",enzymes
R408 T2380 T2381 compound chromatin,remodeling
R409 T2381 T2382 compound remodeling,factors
R410 T2382 T2378 conj factors,enzymes
R411 T2383 T2382 punct ", ",factors
R412 T2384 T2382 cc and,factors
R413 T2385 T2386 compound histone,chaperones
R414 T2386 T2382 conj chaperones,factors
R415 T2387 T2374 prep during,role
R416 T2388 T2389 compound pre-implantation,development
R417 T2389 T2387 pobj development,during
R418 T2390 T2387 punct ", ",during
R419 T2391 T2387 cc or,during
R420 T2392 T2387 conj in,during
R421 T2393 T2394 compound stem,cells
R422 T2394 T2392 pobj cells,in
R423 T2395 T2394 acl derived,cells
R424 T2396 T2395 prep from,derived
R425 T2397 T2398 amod early,embryos
R426 T2398 T2396 pobj embryos,from
R427 T2399 T2400 punct [,6
R428 T2400 T2368 parataxis 6,know
R429 T2401 T2400 punct ],6
R430 T2402 T2368 punct .,know
R431 T2404 T2405 det A,subset
R432 T2405 T2406 nsubj subset,collaborate
R433 T2407 T2405 prep of,subset
R434 T2408 T2409 amod identified,chaperones
R435 T2409 T2407 pobj chaperones,of
R436 T2410 T2409 compound histone,chaperones
R437 T2411 T2409 cc and,chaperones
R438 T2412 T2413 compound chromatin,remodeling
R439 T2413 T2414 compound remodeling,complexes
R440 T2414 T2409 conj complexes,chaperones
R441 T2415 T2406 aux can,collaborate
R442 T2416 T2417 aux to,promote
R443 T2417 T2406 advcl promote,collaborate
R444 T2418 T2419 compound nucleosome,assembly
R445 T2419 T2417 dobj assembly,promote
R446 T2420 T2421 advmod in,vitro
R447 T2421 T2417 advmod vitro,promote
R448 T2422 T2406 cc and,collaborate
R449 T2423 T2406 conj are,collaborate
R450 T2424 T2423 advmod therefore,are
R451 T2425 T2423 prep in,are
R452 T2426 T2427 det a,position
R453 T2427 T2425 pobj position,in
R454 T2428 T2427 amod strategic,position
R455 T2429 T2430 aux to,control
R456 T2430 T2427 advcl control,position
R457 T2431 T2432 compound chromatin,assembly
R458 T2432 T2430 dobj assembly,control
R459 T2433 T2432 cc and,assembly
R460 T2434 T2432 conj maturation,assembly
R461 T2435 T2430 prep during,control
R462 T2436 T2435 pobj development,during
R463 T2437 T2438 punct [,8
R464 T2438 T2423 parataxis 8,are
R465 T2439 T2438 nummod 7,8
R466 T2440 T2438 punct ",",8
R467 T2441 T2438 punct ],8
R468 T2442 T2406 punct .,collaborate
R469 T2444 T2445 prep Among,is
R470 T2446 T2447 compound histone,chaperones
R471 T2447 T2444 pobj chaperones,Among
R472 T2448 T2445 punct ", ",is
R473 T2449 T2450 compound chromatin,assembly
R474 T2450 T2451 compound assembly,factor
R475 T2451 T2445 nsubj factor,is
R476 T2452 T2451 nummod 1,factor
R477 T2453 T2451 punct (,factor
R478 T2454 T2451 appos CAF,factor
R479 T2455 T2454 punct -,CAF
R480 T2456 T2454 nummod 1,CAF
R481 T2457 T2445 punct ),is
R482 T2458 T2459 det a,complex
R483 T2459 T2445 attr complex,is
R484 T2460 T2461 nummod three,subunit
R485 T2461 T2459 nmod subunit,complex
R486 T2462 T2461 punct -,subunit
R487 T2463 T2464 punct (,p150
R488 T2464 T2461 parataxis p150,subunit
R489 T2465 T2464 punct ", ",p150
R490 T2466 T2464 conj p60,p150
R491 T2467 T2466 punct ", ",p60
R492 T2468 T2466 cc and,p60
R493 T2469 T2466 conj p48,p60
R494 T2470 T2464 punct ),p150
R495 T2471 T2472 dep which,promotes
R496 T2472 T2459 relcl promotes,complex
R497 T2473 T2474 nmod histone,H3
R498 T2474 T2475 nmod H3,deposition
R499 T2475 T2472 dobj deposition,promotes
R500 T2476 T2474 cc and,H3
R501 T2477 T2474 conj H4,H3
R502 T2478 T2475 prep onto,deposition
R503 T2479 T2480 advmod newly,synthesized
R504 T2480 T2481 amod synthesized,DNA
R505 T2481 T2478 pobj DNA,onto
R506 T2482 T2472 prep during,promotes
R507 T2483 T2482 pobj replication,during
R508 T2484 T2483 cc or,replication
R509 T2485 T2486 compound DNA,repair
R510 T2486 T2483 conj repair,replication
R511 T2487 T2488 punct [,10
R512 T2488 T2445 parataxis 10,is
R513 T2489 T2488 nummod 9,10
R514 T2490 T2488 punct ",",10
R515 T2491 T2488 punct ],10
R516 T2492 T2445 punct .,is
R517 T2494 T2495 advmod Specifically,deposits
R518 T2496 T2495 punct ", ",deposits
R519 T2497 T2495 nsubj CAF,deposits
R520 T2498 T2497 punct -,CAF
R521 T2499 T2497 nummod 1,CAF
R522 T2500 T2501 det the,variant
R523 T2501 T2495 dobj variant,deposits
R524 T2502 T2503 compound histone,H3
R525 T2503 T2501 compound H3,variant
R526 T2504 T2501 appos H3.1,variant
R527 T2505 T2495 prep into,deposits
R528 T2506 T2505 pobj chromatin,into
R529 T2507 T2495 punct ", ",deposits
R530 T2508 T2495 prep in,deposits
R531 T2509 T2510 det a,pathway
R532 T2510 T2508 pobj pathway,in
R533 T2511 T2510 acl coupled,pathway
R534 T2512 T2511 prep to,coupled
R535 T2513 T2514 compound DNA,synthesis
R536 T2514 T2512 pobj synthesis,to
R537 T2515 T2495 punct ", ",deposits
R538 T2516 T2517 mark whereas,involved
R539 T2517 T2495 advcl involved,deposits
R540 T2518 T2519 det a,chaperone
R541 T2519 T2517 nsubjpass chaperone,involved
R542 T2520 T2519 amod second,chaperone
R543 T2521 T2519 compound histone,chaperone
R544 T2522 T2519 punct ", ",chaperone
R545 T2523 T2519 appos HIRA,chaperone
R546 T2524 T2517 punct ", ",involved
R547 T2525 T2517 auxpass is,involved
R548 T2526 T2517 prep in,involved
R549 T2527 T2528 det the,deposition
R550 T2528 T2526 pobj deposition,in
R551 T2529 T2528 prep of,deposition
R552 T2530 T2531 det the,variant
R553 T2531 T2529 pobj variant,of
R554 T2532 T2531 compound H3.3,variant
R555 T2533 T2528 prep in,deposition
R556 T2534 T2535 det a,pathway
R557 T2535 T2533 pobj pathway,in
R558 T2536 T2537 nmod DNA,synthesis
R559 T2537 T2535 nmod synthesis,pathway
R560 T2538 T2535 amod independent,pathway
R561 T2539 T2540 punct [,12
R562 T2540 T2495 parataxis 12,deposits
R563 T2541 T2540 nummod 11,12
R564 T2542 T2540 punct ",",12
R565 T2543 T2540 punct ],12
R566 T2544 T2495 punct .,deposits
R567 T2546 T2547 prep In,interacts
R568 T2548 T2546 pobj addition,In
R569 T2549 T2548 prep to,addition
R570 T2550 T2551 det this,activity
R571 T2551 T2549 pobj activity,to
R572 T2552 T2551 amod specific,activity
R573 T2553 T2554 compound chromatin,assembly
R574 T2554 T2551 compound assembly,activity
R575 T2555 T2547 punct ", ",interacts
R576 T2556 T2547 nsubj CAF,interacts
R577 T2557 T2556 punct -,CAF
R578 T2558 T2556 nummod 1,CAF
R579 T2559 T2547 prep with,interacts
R580 T2560 T2561 amod several,proteins
R581 T2561 T2559 pobj proteins,with
R582 T2562 T2561 relcl present,proteins
R583 T2563 T2562 prep in,present
R584 T2564 T2563 pobj heterochromatin,in
R585 T2565 T2561 punct ", ",proteins
R586 T2566 T2561 prep including,proteins
R587 T2567 T2568 compound heterochromatin,protein
R588 T2568 T2566 pobj protein,including
R589 T2569 T2568 nummod 1,protein
R590 T2570 T2568 punct (,protein
R591 T2571 T2568 appos HP1,protein
R592 T2572 T2568 punct ),protein
R593 T2573 T2574 cc and,MBD1
R594 T2574 T2568 appos MBD1,protein
R595 T2575 T2574 punct ", ",MBD1
R596 T2576 T2577 det a,protein
R597 T2577 T2574 appos protein,MBD1
R598 T2578 T2579 compound methyl,CpG
R599 T2579 T2577 compound CpG,protein
R600 T2580 T2579 punct -,CpG
R601 T2581 T2582 compound binding,domain
R602 T2582 T2577 compound domain,protein
R603 T2583 T2584 dep that,recruits
R604 T2584 T2577 relcl recruits,protein
R605 T2585 T2586 nmod histone,deacetylase
R606 T2586 T2587 nmod deacetylase,activities
R607 T2587 T2584 dobj activities,recruits
R608 T2588 T2586 cc and,deacetylase
R609 T2589 T2590 amod repressive,methyltransferase
R610 T2590 T2586 conj methyltransferase,deacetylase
R611 T2591 T2590 compound histone,methyltransferase
R612 T2592 T2593 punct [,13
R613 T2593 T2547 parataxis 13,interacts
R614 T2594 T2595 punct –,15
R615 T2595 T2593 prep 15,13
R616 T2596 T2593 punct ],13
R617 T2597 T2547 punct .,interacts
R618 T2599 T2600 advmod Furthermore,required
R619 T2601 T2600 punct ", ",required
R620 T2602 T2600 nsubjpass p150CAF,required
R621 T2603 T2602 punct -,p150CAF
R622 T2604 T2602 nummod 1,p150CAF
R623 T2605 T2600 auxpass is,required
R624 T2606 T2607 aux to,ensure
R625 T2607 T2600 advcl ensure,required
R626 T2608 T2609 det a,pool
R627 T2609 T2607 dobj pool,ensure
R628 T2610 T2611 npadvmod replication,specific
R629 T2611 T2609 amod specific,pool
R630 T2612 T2611 punct -,specific
R631 T2613 T2609 prep of,pool
R632 T2614 T2615 compound HP1,molecules
R633 T2615 T2613 pobj molecules,of
R634 T2616 T2607 prep at,ensure
R635 T2617 T2618 compound replication,sites
R636 T2618 T2616 pobj sites,at
R637 T2619 T2618 prep in,sites
R638 T2620 T2621 amod pericentric,heterochromatin
R639 T2621 T2619 pobj heterochromatin,in
R640 T2622 T2607 prep during,ensure
R641 T2623 T2624 amod mid,late
R642 T2624 T2626 amod late,phase
R643 T2625 T2624 punct -,late
R644 T2626 T2622 pobj phase,during
R645 T2627 T2626 compound S,phase
R646 T2628 T2629 punct [,16
R647 T2629 T2600 parataxis 16,required
R648 T2630 T2629 punct ],16
R649 T2631 T2600 punct .,required
R650 T2633 T2634 advcl Taken,suggest
R651 T2635 T2633 advmod together,Taken
R652 T2636 T2634 punct ", ",suggest
R653 T2637 T2638 det these,data
R654 T2638 T2634 nsubj data,suggest
R655 T2639 T2634 dobj roles,suggest
R656 T2640 T2639 prep for,roles
R657 T2641 T2640 pobj CAF,for
R658 T2642 T2641 punct -,CAF
R659 T2643 T2641 nummod 1,CAF
R660 T2644 T2639 prep in,roles
R661 T2645 T2646 det the,formation
R662 T2646 T2644 pobj formation,in
R663 T2647 T2646 prep of,formation
R664 T2648 T2647 pobj heterochromatin,of
R665 T2649 T2644 cc and,in
R666 T2650 T2644 conj in,in
R667 T2651 T2652 det the,heritability
R668 T2652 T2650 pobj heritability,in
R669 T2653 T2652 prep of,heritability
R670 T2654 T2655 amod epigenetic,traits
R671 T2655 T2653 pobj traits,of
R672 T2656 T2634 punct .,suggest
R673 T2658 T2659 mark While,studied
R674 T2659 T2670 advcl studied,lack
R675 T2660 T2661 det the,function
R676 T2661 T2659 nsubjpass function,studied
R677 T2662 T2661 prep of,function
R678 T2663 T2664 det this,chaperone
R679 T2664 T2662 pobj chaperone,of
R680 T2665 T2666 amod evolutionary,conserved
R681 T2666 T2664 amod conserved,chaperone
R682 T2667 T2664 compound histone,chaperone
R683 T2668 T2659 aux has,studied
R684 T2669 T2659 auxpass been,studied
R685 T2671 T2659 advmod extensively,studied
R686 T2672 T2659 advmod biochemically,studied
R687 T2673 T2670 punct ", ",lack
R688 T2674 T2670 nsubj we,lack
R689 T2675 T2670 advmod still,lack
R690 T2676 T2670 dobj information,lack
R691 T2677 T2676 prep concerning,information
R692 T2678 T2679 poss its,importance
R693 T2679 T2677 pobj importance,concerning
R694 T2680 T2679 prep during,importance
R695 T2681 T2682 amod early,development
R696 T2682 T2680 pobj development,during
R697 T2683 T2679 prep in,importance
R698 T2684 T2683 pobj mammals,in
R699 T2685 T2683 cc and,in
R700 T2686 T2683 conj in,in
R701 T2687 T2688 amod pluripotent,cells
R702 T2688 T2686 pobj cells,in
R703 T2689 T2690 amod such,as
R704 T2690 T2688 prep as,cells
R705 T2691 T2692 amod embryonic,stem
R706 T2692 T2693 nmod stem,cells
R707 T2693 T2690 pobj cells,as
R708 T2694 T2692 punct (,stem
R709 T2695 T2692 appos ES,stem
R710 T2696 T2693 punct ),cells
R711 T2697 T2670 punct .,lack
R712 T2699 T2700 advmod Here,analyzed
R713 T2701 T2700 punct ", ",analyzed
R714 T2702 T2700 nsubj we,analyzed
R715 T2703 T2700 aux have,analyzed
R716 T2704 T2705 det the,importance
R717 T2705 T2700 dobj importance,analyzed
R718 T2706 T2705 prep of,importance
R719 T2707 T2706 pobj CAF,of
R720 T2708 T2707 punct -,CAF
R721 T2709 T2707 nummod 1,CAF
R722 T2710 T2705 prep during,importance
R723 T2711 T2712 amod early,development
R724 T2712 T2710 pobj development,during
R725 T2713 T2712 compound mouse,development
R726 T2714 T2700 prep by,analyzed
R727 T2715 T2716 amod genetic,ablation
R728 T2716 T2714 pobj ablation,by
R729 T2717 T2700 cc and,analyzed
R730 T2718 T2700 conj in,analyzed
R731 T2719 T2720 compound ES,cells
R732 T2720 T2718 pobj cells,in
R733 T2721 T2718 prep by,in
R734 T2722 T2721 pobj depletion,by
R735 T2723 T2722 acl using,depletion
R736 T2724 T2725 compound RNA,interference
R737 T2725 T2723 dobj interference,using
R738 T2726 T2725 punct (,interference
R739 T2727 T2725 appos RNAi,interference
R740 T2728 T2700 punct ),analyzed
R741 T2729 T2700 punct .,analyzed
R742 T2731 T2732 nsubj We,show
R743 T2733 T2734 mark that,is
R744 T2734 T2732 ccomp is,show
R745 T2735 T2734 nsubj CAF,is
R746 T2736 T2735 punct -,CAF
R747 T2737 T2735 nummod 1,CAF
R748 T2738 T2734 acomp essential,is
R749 T2739 T2738 prep for,essential
R750 T2740 T2739 pobj viability,for
R751 T2741 T2734 prep in,is
R752 T2742 T2743 amod early,embryos
R753 T2743 T2741 pobj embryos,in
R754 T2744 T2743 compound mouse,embryos
R755 T2745 T2743 cc and,embryos
R756 T2746 T2747 compound ES,cells
R757 T2747 T2743 conj cells,embryos
R758 T2748 T2732 punct .,show
R759 T2750 T2751 nsubj We,provide
R760 T2752 T2751 dobj evidence,provide
R761 T2753 T2754 mark that,required
R762 T2754 T2752 acl required,evidence
R763 T2755 T2754 nsubjpass CAF,required
R764 T2756 T2755 punct -,CAF
R765 T2757 T2755 nummod 1,CAF
R766 T2758 T2754 auxpass is,required
R767 T2759 T2754 prep for,required
R768 T2760 T2761 det the,organization
R769 T2761 T2759 pobj organization,for
R770 T2762 T2761 amod spatial,organization
R771 T2763 T2761 cc and,organization
R772 T2764 T2765 amod epigenetic,marking
R773 T2765 T2761 conj marking,organization
R774 T2766 T2761 prep of,organization
R775 T2767 T2768 compound heterochromatin,domains
R776 T2768 T2766 pobj domains,of
R777 T2769 T2768 prep in,domains
R778 T2770 T2771 amod pluripotent,cells
R779 T2771 T2769 pobj cells,in
R780 T2772 T2771 amod embryonic,cells
R781 T2773 T2751 punct .,provide