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PMC:1626108 / 7780-12818 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2102 0-3 DT denotes The
T2103 4-6 NN denotes LD
T2105 7-9 IN denotes of
T2106 10-16 NN denotes RanBP2
T2104 17-26 VBZ denotes Interacts
T2107 27-31 IN denotes with
T2108 32-37 NN denotes Cox11
T2109 38-41 CC denotes and
T2110 42-45 NN denotes HKI
T2111 45-201 sentence denotes The LD of RanBP2 (Figure 1A) is a large and orphan domain of ~700 residues (~80 kDa), for which no molecular partners have been identified until this date.
T2112 46-49 DT denotes The
T2113 50-52 NN denotes LD
T2115 53-55 IN denotes of
T2116 56-62 NN denotes RanBP2
T2117 63-64 -LRB- denotes (
T2119 64-70 NN denotes Figure
T2118 71-73 NN denotes 1A
T2120 73-74 -RRB- denotes )
T2114 75-77 VBZ denotes is
T2121 78-79 DT denotes a
T2123 80-85 JJ denotes large
T2124 86-89 CC denotes and
T2125 90-96 NN denotes orphan
T2122 97-103 NN denotes domain
T2126 104-106 IN denotes of
T2127 107-108 SYM denotes ~
T2128 108-111 CD denotes 700
T2129 112-120 NNS denotes residues
T2130 121-122 -LRB- denotes (
T2131 122-123 SYM denotes ~
T2132 123-125 CD denotes 80
T2133 126-129 NN denotes kDa
T2134 129-130 -RRB- denotes )
T2135 130-132 , denotes ,
T2136 132-135 IN denotes for
T2138 136-141 WDT denotes which
T2139 142-144 DT denotes no
T2141 145-154 JJ denotes molecular
T2140 155-163 NNS denotes partners
T2142 164-168 VBP denotes have
T2143 169-173 VBN denotes been
T2137 174-184 VBN denotes identified
T2144 185-190 IN denotes until
T2145 191-195 DT denotes this
T2146 196-200 NN denotes date
T2147 200-201 . denotes .
T2148 201-268 sentence denotes Brain and retina yeast two-hybrid libraries were screened with LD.
T2149 202-207 NN denotes Brain
T2151 208-211 CC denotes and
T2152 212-218 NN denotes retina
T2153 219-224 NN denotes yeast
T2154 225-228 CD denotes two
T2156 228-229 HYPH denotes -
T2155 229-235 NN denotes hybrid
T2150 236-245 NNS denotes libraries
T2158 246-250 VBD denotes were
T2157 251-259 VBN denotes screened
T2159 260-264 IN denotes with
T2160 265-267 NN denotes LD
T2161 267-268 . denotes .
T2162 268-337 sentence denotes Cox11 was identified as a partner to this domain (Figure 1B and 1C).
T2163 269-274 NN denotes Cox11
T2165 275-278 VBD denotes was
T2164 279-289 VBN denotes identified
T2166 290-292 IN denotes as
T2167 293-294 DT denotes a
T2168 295-302 NN denotes partner
T2169 303-305 IN denotes to
T2170 306-310 DT denotes this
T2171 311-317 NN denotes domain
T2172 318-319 -LRB- denotes (
T2174 319-325 NN denotes Figure
T2173 326-328 NN denotes 1B
T2175 329-332 CC denotes and
T2176 333-335 NN denotes 1C
T2177 335-336 -RRB- denotes )
T2178 336-337 . denotes .
T2179 337-418 sentence denotes Cox11 is a metallochaperone implicated in cytochrome c oxidase assembly [30,31].
T2180 338-343 NN denotes Cox11
T2181 344-346 VBZ denotes is
T2182 347-348 DT denotes a
T2183 349-365 NN denotes metallochaperone
T2184 366-376 VBN denotes implicated
T2185 377-379 IN denotes in
T2186 380-390 NN denotes cytochrome
T2188 391-392 NN denotes c
T2187 393-400 NN denotes oxidase
T2189 401-409 NN denotes assembly
T2190 410-411 -LRB- denotes [
T2192 411-413 CD denotes 30
T2193 413-414 , denotes ,
T2191 414-416 CD denotes 31
T2194 416-417 -RRB- denotes ]
T2195 417-418 . denotes .
T2196 418-648 sentence denotes Structure-function analysis of the interaction between mCox11, LD of RanBP2, and subdomains thereof, with quantitative yeast two-hybrid assays [32], showed optimal interaction between the intact LD and Cox11 proteins (Figure 1C).
T2197 419-428 NN denotes Structure
T2199 428-429 HYPH denotes -
T2198 429-437 NN denotes function
T2200 438-446 NN denotes analysis
T2202 447-449 IN denotes of
T2203 450-453 DT denotes the
T2204 454-465 NN denotes interaction
T2205 466-473 IN denotes between
T2206 474-480 NN denotes mCox11
T2207 480-482 , denotes ,
T2208 482-484 NN denotes LD
T2209 485-487 IN denotes of
T2210 488-494 NN denotes RanBP2
T2211 494-496 , denotes ,
T2212 496-499 CC denotes and
T2213 500-510 NNS denotes subdomains
T2214 511-518 RB denotes thereof
T2215 518-520 , denotes ,
T2216 520-524 IN denotes with
T2217 525-537 JJ denotes quantitative
T2219 538-543 NN denotes yeast
T2220 544-547 CD denotes two
T2222 547-548 HYPH denotes -
T2221 548-554 NN denotes hybrid
T2218 555-561 NNS denotes assays
T2223 562-563 -LRB- denotes [
T2224 563-565 CD denotes 32
T2225 565-566 -RRB- denotes ]
T2226 566-568 , denotes ,
T2201 568-574 VBD denotes showed
T2227 575-582 JJ denotes optimal
T2228 583-594 NN denotes interaction
T2229 595-602 IN denotes between
T2230 603-606 DT denotes the
T2232 607-613 JJ denotes intact
T2233 614-616 NN denotes LD
T2234 617-620 CC denotes and
T2235 621-626 NN denotes Cox11
T2231 627-635 NN denotes proteins
T2236 636-637 -LRB- denotes (
T2238 637-643 NN denotes Figure
T2237 644-646 NN denotes 1C
T2239 646-647 -RRB- denotes )
T2240 647-648 . denotes .
T2241 648-860 sentence denotes Pull-down assays of retinal extracts with glutathione S-transferase (GST)-LD precipitates a sodium dodecyl sulfate-resistant dimer isoform of Cox11 (Figure 1D, top panel), which does not bind to GST-LDZIP alone.
T2242 649-653 VB denotes Pull
T2244 653-654 HYPH denotes -
T2245 654-658 RP denotes down
T2243 659-665 NNS denotes assays
T2247 666-668 IN denotes of
T2248 669-676 JJ denotes retinal
T2249 677-685 NNS denotes extracts
T2250 686-690 IN denotes with
T2251 691-702 NN denotes glutathione
T2253 703-704 NN denotes S
T2254 704-705 HYPH denotes -
T2252 705-716 NN denotes transferase
T2256 717-718 -LRB- denotes (
T2257 718-721 NN denotes GST
T2258 721-722 -RRB- denotes )
T2259 722-723 HYPH denotes -
T2255 723-725 NN denotes LD
T2246 726-738 VBZ denotes precipitates
T2260 739-740 DT denotes a
T2262 741-747 NN denotes sodium
T2264 748-755 NN denotes dodecyl
T2263 756-763 NN denotes sulfate
T2266 763-764 HYPH denotes -
T2265 764-773 JJ denotes resistant
T2267 774-779 NN denotes dimer
T2261 780-787 NN denotes isoform
T2268 788-790 IN denotes of
T2269 791-796 NN denotes Cox11
T2270 797-798 -LRB- denotes (
T2272 798-804 NN denotes Figure
T2273 805-807 NN denotes 1D
T2274 807-809 , denotes ,
T2275 809-812 JJ denotes top
T2271 813-818 NN denotes panel
T2276 818-819 -RRB- denotes )
T2277 819-821 , denotes ,
T2278 821-826 WDT denotes which
T2280 827-831 VBZ denotes does
T2281 832-835 RB denotes not
T2279 836-840 VB denotes bind
T2282 841-843 IN denotes to
T2283 844-847 NN denotes GST
T2285 847-848 HYPH denotes -
T2284 848-853 NN denotes LDZIP
T2286 854-859 RB denotes alone
T2287 859-860 . denotes .
T2288 860-1075 sentence denotes In addition to Cox11, we also found that other mitochondrial components such as the outer membrane-associated protein, HKI [33] (Figure 1D, bottom panel) and mHsp70 (unpublished data), associated with LD of RanBP2.
T2289 861-863 IN denotes In
T2291 864-872 NN denotes addition
T2292 873-875 IN denotes to
T2293 876-881 NN denotes Cox11
T2294 881-883 , denotes ,
T2295 883-885 PRP denotes we
T2296 886-890 RB denotes also
T2290 891-896 VBD denotes found
T2297 897-901 IN denotes that
T2299 902-907 JJ denotes other
T2301 908-921 JJ denotes mitochondrial
T2300 922-932 NNS denotes components
T2302 933-937 JJ denotes such
T2303 938-940 IN denotes as
T2304 941-944 DT denotes the
T2306 945-950 JJ denotes outer
T2307 951-959 NN denotes membrane
T2309 959-960 HYPH denotes -
T2308 960-970 VBN denotes associated
T2305 971-978 NN denotes protein
T2310 978-980 , denotes ,
T2311 980-983 NN denotes HKI
T2312 984-985 -LRB- denotes [
T2313 985-987 CD denotes 33
T2314 987-988 -RRB- denotes ]
T2315 989-990 -LRB- denotes (
T2317 990-996 NN denotes Figure
T2318 997-999 NN denotes 1D
T2319 999-1001 , denotes ,
T2320 1001-1007 JJ denotes bottom
T2316 1008-1013 NN denotes panel
T2321 1013-1014 -RRB- denotes )
T2322 1015-1018 CC denotes and
T2323 1019-1025 NN denotes mHsp70
T2324 1026-1027 -LRB- denotes (
T2326 1027-1038 JJ denotes unpublished
T2325 1039-1043 NNS denotes data
T2327 1043-1044 -RRB- denotes )
T2328 1044-1046 , denotes ,
T2298 1046-1056 VBD denotes associated
T2329 1057-1061 IN denotes with
T2330 1062-1064 NN denotes LD
T2331 1065-1067 IN denotes of
T2332 1068-1074 NN denotes RanBP2
T2333 1074-1075 . denotes .
T2334 1075-1232 sentence denotes This association was highly specific toward the HKI isoform, because HKII, HKIII, and glucokinase did not interact with the LD of RanBP2 (unpublished data).
T2335 1076-1080 DT denotes This
T2336 1081-1092 NN denotes association
T2337 1093-1096 VBD denotes was
T2338 1097-1103 RB denotes highly
T2339 1104-1112 JJ denotes specific
T2340 1113-1119 IN denotes toward
T2341 1120-1123 DT denotes the
T2343 1124-1127 NN denotes HKI
T2342 1128-1135 NN denotes isoform
T2344 1135-1137 , denotes ,
T2345 1137-1144 IN denotes because
T2347 1145-1149 NN denotes HKII
T2348 1149-1151 , denotes ,
T2349 1151-1156 NN denotes HKIII
T2350 1156-1158 , denotes ,
T2351 1158-1161 CC denotes and
T2352 1162-1173 NN denotes glucokinase
T2353 1174-1177 VBD denotes did
T2354 1178-1181 RB denotes not
T2346 1182-1190 VB denotes interact
T2355 1191-1195 IN denotes with
T2356 1196-1199 DT denotes the
T2357 1200-1202 NN denotes LD
T2358 1203-1205 IN denotes of
T2359 1206-1212 NN denotes RanBP2
T2360 1213-1214 -LRB- denotes (
T2362 1214-1225 JJ denotes unpublished
T2361 1226-1230 NNS denotes data
T2363 1230-1231 -RRB- denotes )
T2364 1231-1232 . denotes .
T2365 1232-1516 sentence denotes The interaction of Cox11, HKI, and mHsp70 with RanBP2 occurred in vivo in retinal extracts, since antibodies against these and RanBP2 coimmunoprecipitated RanBP2 (Figure 1E) and HKI (Figure 1F), respectively, and these interactions were observed across different tissues (Figure S1).
T2366 1233-1236 DT denotes The
T2367 1237-1248 NN denotes interaction
T2369 1249-1251 IN denotes of
T2370 1252-1257 NN denotes Cox11
T2371 1257-1259 , denotes ,
T2372 1259-1262 NN denotes HKI
T2373 1262-1264 , denotes ,
T2374 1264-1267 CC denotes and
T2375 1268-1274 NN denotes mHsp70
T2376 1275-1279 IN denotes with
T2377 1280-1286 NN denotes RanBP2
T2368 1287-1295 VBD denotes occurred
T2378 1296-1298 FW denotes in
T2379 1299-1303 FW denotes vivo
T2380 1304-1306 IN denotes in
T2381 1307-1314 JJ denotes retinal
T2382 1315-1323 NNS denotes extracts
T2383 1323-1325 , denotes ,
T2384 1325-1330 IN denotes since
T2386 1331-1341 NNS denotes antibodies
T2387 1342-1349 IN denotes against
T2388 1350-1355 DT denotes these
T2390 1356-1359 CC denotes and
T2389 1360-1366 NN denotes RanBP2
T2385 1367-1387 VBD denotes coimmunoprecipitated
T2391 1388-1394 NN denotes RanBP2
T2392 1395-1396 -LRB- denotes (
T2394 1396-1402 NN denotes Figure
T2393 1403-1405 NN denotes 1E
T2395 1405-1406 -RRB- denotes )
T2396 1407-1410 CC denotes and
T2397 1411-1414 NN denotes HKI
T2398 1415-1416 -LRB- denotes (
T2400 1416-1422 NN denotes Figure
T2399 1423-1425 NN denotes 1F
T2401 1425-1426 -RRB- denotes )
T2402 1426-1428 , denotes ,
T2403 1428-1440 RB denotes respectively
T2404 1440-1442 , denotes ,
T2405 1442-1445 CC denotes and
T2406 1446-1451 DT denotes these
T2407 1452-1464 NNS denotes interactions
T2409 1465-1469 VBD denotes were
T2408 1470-1478 VBN denotes observed
T2410 1479-1485 IN denotes across
T2411 1486-1495 JJ denotes different
T2412 1496-1503 NNS denotes tissues
T2413 1504-1505 -LRB- denotes (
T2415 1505-1511 NN denotes Figure
T2414 1512-1514 NN denotes S1
T2416 1514-1515 -RRB- denotes )
T2417 1515-1516 . denotes .
T2418 1516-1706 sentence denotes Since RanBP2 exhibits chaperone activity, we assessed whether the interaction between the LD of RanBP2 and Cox11 was direct and the chaperone activity of LD toward folding species of Cox11.
T2419 1517-1522 IN denotes Since
T2421 1523-1529 NN denotes RanBP2
T2420 1530-1538 VBZ denotes exhibits
T2423 1539-1548 NN denotes chaperone
T2424 1549-1557 NN denotes activity
T2425 1557-1559 , denotes ,
T2426 1559-1561 PRP denotes we
T2422 1562-1570 VBD denotes assessed
T2427 1571-1578 IN denotes whether
T2429 1579-1582 DT denotes the
T2430 1583-1594 NN denotes interaction
T2431 1595-1602 IN denotes between
T2432 1603-1606 DT denotes the
T2433 1607-1609 NN denotes LD
T2434 1610-1612 IN denotes of
T2435 1613-1619 NN denotes RanBP2
T2436 1620-1623 CC denotes and
T2437 1624-1629 NN denotes Cox11
T2428 1630-1633 VBD denotes was
T2438 1634-1640 JJ denotes direct
T2439 1641-1644 CC denotes and
T2441 1645-1648 DT denotes the
T2442 1649-1658 NN denotes chaperone
T2440 1659-1667 NN denotes activity
T2443 1668-1670 IN denotes of
T2444 1671-1673 NN denotes LD
T2445 1674-1680 IN denotes toward
T2446 1681-1688 VBG denotes folding
T2447 1689-1696 NNS denotes species
T2448 1697-1699 IN denotes of
T2449 1700-1705 NN denotes Cox11
T2450 1705-1706 . denotes .
T2451 1706-1886 sentence denotes Reconstitution binding assays were carried out between purified LD and Cox11, fully and partially denatured with GnHCl and urea, respectively, and native Cox11 (Figure 1G and 1H).
T2452 1707-1721 NN denotes Reconstitution
T2453 1722-1729 NN denotes binding
T2454 1730-1736 NNS denotes assays
T2456 1737-1741 VBD denotes were
T2455 1742-1749 VBN denotes carried
T2457 1750-1753 RP denotes out
T2458 1754-1761 IN denotes between
T2459 1762-1770 VBN denotes purified
T2460 1771-1773 NN denotes LD
T2461 1774-1777 CC denotes and
T2462 1778-1783 NN denotes Cox11
T2463 1783-1785 , denotes ,
T2464 1785-1790 RB denotes fully
T2466 1791-1794 CC denotes and
T2467 1795-1804 RB denotes partially
T2465 1805-1814 VBN denotes denatured
T2468 1815-1819 IN denotes with
T2469 1820-1825 NN denotes GnHCl
T2470 1826-1829 CC denotes and
T2471 1830-1834 NN denotes urea
T2472 1834-1836 , denotes ,
T2473 1836-1848 RB denotes respectively
T2474 1848-1850 , denotes ,
T2475 1850-1853 CC denotes and
T2476 1854-1860 JJ denotes native
T2477 1861-1866 NN denotes Cox11
T2478 1867-1868 -LRB- denotes (
T2480 1868-1874 NN denotes Figure
T2479 1875-1877 NN denotes 1G
T2481 1878-1881 CC denotes and
T2482 1882-1884 NN denotes 1H
T2483 1884-1885 -RRB- denotes )
T2484 1885-1886 . denotes .
T2485 1886-2059 sentence denotes Partial denatured Cox11 exhibits significantly higher and concentration-dependent binding affinity toward LD compared with the native and fully denatured Cox11 (Figure 1G).
T2486 1887-1894 JJ denotes Partial
T2487 1895-1904 VBN denotes denatured
T2488 1905-1910 NN denotes Cox11
T2489 1911-1919 VBZ denotes exhibits
T2490 1920-1933 RB denotes significantly
T2491 1934-1940 JJR denotes higher
T2493 1941-1944 CC denotes and
T2494 1945-1958 NN denotes concentration
T2496 1958-1959 HYPH denotes -
T2495 1959-1968 JJ denotes dependent
T2497 1969-1976 NN denotes binding
T2492 1977-1985 NN denotes affinity
T2498 1986-1992 IN denotes toward
T2499 1993-1995 NN denotes LD
T2500 1996-2004 VBN denotes compared
T2501 2005-2009 IN denotes with
T2502 2010-2013 DT denotes the
T2504 2014-2020 JJ denotes native
T2505 2021-2024 CC denotes and
T2506 2025-2030 RB denotes fully
T2507 2031-2040 VBN denotes denatured
T2503 2041-2046 NN denotes Cox11
T2508 2047-2048 -LRB- denotes (
T2510 2048-2054 NN denotes Figure
T2509 2055-2057 NN denotes 1G
T2511 2057-2058 -RRB- denotes )
T2512 2058-2059 . denotes .
T2513 2059-2296 sentence denotes In addition, native Cox11 purified upon expression in the presence of CuSO4 (a prosthetic group tightly bound to Cox11) [31], shows significantly higher binding activity toward the LD of RanBP2, than in the absence of CuSO4 (Figure 1H).
T2514 2060-2062 IN denotes In
T2516 2063-2071 NN denotes addition
T2517 2071-2073 , denotes ,
T2518 2073-2079 JJ denotes native
T2519 2080-2085 NN denotes Cox11
T2520 2086-2094 VBN denotes purified
T2521 2095-2099 IN denotes upon
T2522 2100-2110 NN denotes expression
T2523 2111-2113 IN denotes in
T2524 2114-2117 DT denotes the
T2525 2118-2126 NN denotes presence
T2526 2127-2129 IN denotes of
T2527 2130-2135 NN denotes CuSO4
T2528 2136-2137 -LRB- denotes (
T2529 2137-2138 DT denotes a
T2531 2139-2149 JJ denotes prosthetic
T2530 2150-2155 NN denotes group
T2532 2156-2163 RB denotes tightly
T2533 2164-2169 VBN denotes bound
T2534 2170-2172 IN denotes to
T2535 2173-2178 NN denotes Cox11
T2536 2178-2179 -RRB- denotes )
T2537 2180-2181 -LRB- denotes [
T2538 2181-2183 CD denotes 31
T2539 2183-2184 -RRB- denotes ]
T2540 2184-2186 , denotes ,
T2515 2186-2191 VBZ denotes shows
T2541 2192-2205 RB denotes significantly
T2542 2206-2212 JJR denotes higher
T2544 2213-2220 NN denotes binding
T2543 2221-2229 NN denotes activity
T2545 2230-2236 IN denotes toward
T2546 2237-2240 DT denotes the
T2547 2241-2243 NN denotes LD
T2548 2244-2246 IN denotes of
T2549 2247-2253 NN denotes RanBP2
T2550 2253-2255 , denotes ,
T2551 2255-2259 IN denotes than
T2552 2260-2262 IN denotes in
T2553 2263-2266 DT denotes the
T2554 2267-2274 NN denotes absence
T2555 2275-2277 IN denotes of
T2556 2278-2283 NN denotes CuSO4
T2557 2284-2285 -LRB- denotes (
T2559 2285-2291 NN denotes Figure
T2558 2292-2294 NN denotes 1H
T2560 2294-2295 -RRB- denotes )
T2561 2295-2296 . denotes .
T10852 2307-2310 DT denotes The
T10853 2311-2313 NN denotes LD
T10855 2314-2316 IN denotes of
T10856 2317-2323 NN denotes RanBP2
T10854 2324-2333 VBZ denotes Interacts
T10857 2334-2338 IN denotes with
T10858 2339-2344 NN denotes Cox11
T10859 2345-2348 CC denotes and
T10860 2349-2352 NN denotes HKI
T10861 2352-2423 sentence denotes (A) Primary structure of RanBP2 and its structural/functional domains.
T10862 2353-2354 -LRB- denotes (
T10863 2354-2355 LS denotes A
T10865 2355-2356 -RRB- denotes )
T10866 2357-2364 JJ denotes Primary
T10864 2365-2374 NN denotes structure
T10867 2375-2377 IN denotes of
T10868 2378-2384 NN denotes RanBP2
T10869 2385-2388 CC denotes and
T10870 2389-2392 PRP$ denotes its
T10872 2393-2403 JJ denotes structural
T10874 2403-2404 HYPH denotes /
T10873 2404-2414 JJ denotes functional
T10871 2415-2422 NNS denotes domains
T10875 2422-2423 . denotes .
T10876 2423-2466 sentence denotes The N-terminal LD of RanBP2 is underlined.
T10877 2424-2427 DT denotes The
T10879 2428-2429 NN denotes N
T10881 2429-2430 HYPH denotes -
T10880 2430-2438 JJ denotes terminal
T10878 2439-2441 NN denotes LD
T10883 2442-2444 IN denotes of
T10884 2445-2451 NN denotes RanBP2
T10885 2452-2454 VBZ denotes is
T10882 2455-2465 VBN denotes underlined
T10886 2465-2466 . denotes .
T10887 2466-2516 sentence denotes (B) Sequence alignment of murine and yeast Cox11.
T10888 2467-2468 -LRB- denotes (
T10889 2468-2469 LS denotes B
T10891 2469-2470 -RRB- denotes )
T10892 2471-2479 NN denotes Sequence
T10890 2480-2489 NN denotes alignment
T10893 2490-2492 IN denotes of
T10894 2493-2499 JJ denotes murine
T10896 2500-2503 CC denotes and
T10897 2504-2509 NN denotes yeast
T10895 2510-2515 NN denotes Cox11
T10898 2515-2516 . denotes .
T10899 2516-2580 sentence denotes The yeast Cox11 C- and N-terminal domains are poorly conserved.
T10900 2517-2520 DT denotes The
T10902 2521-2526 NN denotes yeast
T10903 2527-2532 NN denotes Cox11
T10904 2533-2534 NN denotes C
T10906 2534-2535 HYPH denotes -
T10907 2536-2539 CC denotes and
T10908 2540-2541 NN denotes N
T10909 2541-2542 HYPH denotes -
T10905 2542-2550 JJ denotes terminal
T10901 2551-2558 NNS denotes domains
T10911 2559-2562 VBP denotes are
T10912 2563-2569 RB denotes poorly
T10910 2570-2579 VBN denotes conserved
T10913 2579-2580 . denotes .
T10914 2580-2680 sentence denotes Arrow and solid line denote the predicted mitochondrial cleavage site and membrane-spanning domain.
T10915 2581-2586 NN denotes Arrow
T10917 2587-2590 CC denotes and
T10918 2591-2596 JJ denotes solid
T10919 2597-2601 NN denotes line
T10916 2602-2608 VBP denotes denote
T10920 2609-2612 DT denotes the
T10922 2613-2622 VBN denotes predicted
T10923 2623-2636 JJ denotes mitochondrial
T10924 2637-2645 NN denotes cleavage
T10921 2646-2650 NN denotes site
T10925 2651-2654 CC denotes and
T10926 2655-2663 NN denotes membrane
T10928 2663-2664 HYPH denotes -
T10927 2664-2672 VBG denotes spanning
T10929 2673-2679 NN denotes domain
T10930 2679-2680 . denotes .
T10931 2680-2812 sentence denotes The dotted and dashed lines above the aligned sequences represent, respectively, Cox11-N and Cox11-C constructs shown in Figure 1C.
T10932 2681-2684 DT denotes The
T10934 2685-2691 JJ denotes dotted
T10935 2692-2695 CC denotes and
T10936 2696-2702 JJ denotes dashed
T10933 2703-2708 NNS denotes lines
T10938 2709-2714 IN denotes above
T10939 2715-2718 DT denotes the
T10941 2719-2726 JJ denotes aligned
T10940 2727-2736 NNS denotes sequences
T10937 2737-2746 VBP denotes represent
T10942 2746-2748 , denotes ,
T10943 2748-2760 RB denotes respectively
T10944 2760-2762 , denotes ,
T10945 2762-2767 NN denotes Cox11
T10947 2767-2768 HYPH denotes -
T10946 2768-2769 NN denotes N
T10949 2770-2773 CC denotes and
T10950 2774-2779 NN denotes Cox11
T10952 2779-2780 HYPH denotes -
T10951 2780-2781 NN denotes C
T10948 2782-2792 NNS denotes constructs
T10953 2793-2798 VBN denotes shown
T10954 2799-2801 IN denotes in
T10955 2802-2808 NN denotes Figure
T10956 2809-2811 NN denotes 1C
T10957 2811-2812 . denotes .
T10958 2812-2899 sentence denotes (C) Structure-function analysis of the interaction between the LD of RanBP2 and Cox11.
T10959 2813-2814 -LRB- denotes (
T10960 2814-2815 LS denotes C
T10962 2815-2816 -RRB- denotes )
T10963 2817-2826 NN denotes Structure
T10965 2826-2827 HYPH denotes -
T10964 2827-2835 NN denotes function
T10961 2836-2844 NN denotes analysis
T10966 2845-2847 IN denotes of
T10967 2848-2851 DT denotes the
T10968 2852-2863 NN denotes interaction
T10969 2864-2871 IN denotes between
T10970 2872-2875 DT denotes the
T10971 2876-2878 NN denotes LD
T10972 2879-2881 IN denotes of
T10973 2882-2888 NN denotes RanBP2
T10974 2889-2892 CC denotes and
T10975 2893-2898 NN denotes Cox11
T10976 2898-2899 . denotes .
T10977 2899-3026 sentence denotes Optimal interaction between the LD and Cox11 occurred in the presence of constructs comprising both the complete LD and Cox11.
T10978 2900-2907 JJ denotes Optimal
T10979 2908-2919 NN denotes interaction
T10981 2920-2927 IN denotes between
T10982 2928-2931 DT denotes the
T10983 2932-2934 NN denotes LD
T10984 2935-2938 CC denotes and
T10985 2939-2944 NN denotes Cox11
T10980 2945-2953 VBD denotes occurred
T10986 2954-2956 IN denotes in
T10987 2957-2960 DT denotes the
T10988 2961-2969 NN denotes presence
T10989 2970-2972 IN denotes of
T10990 2973-2983 NNS denotes constructs
T10991 2984-2994 VBG denotes comprising
T10992 2995-2999 CC denotes both
T10994 3000-3003 DT denotes the
T10995 3004-3012 JJ denotes complete
T10993 3013-3015 NN denotes LD
T10996 3016-3019 CC denotes and
T10997 3020-3025 NN denotes Cox11
T10998 3025-3026 . denotes .
T10999 3026-3278 sentence denotes Although removal of the cytosolic N-terminal (Cox11-C) significantly decreased the interaction with LD, the mitochondrial intermembrane domain of Cox11 (Cox11-C) together with the C-terminal half of LD (LD-C) retained most of the interaction activity.
T11000 3027-3035 IN denotes Although
T11002 3036-3043 NN denotes removal
T11003 3044-3046 IN denotes of
T11004 3047-3050 DT denotes the
T11006 3051-3060 JJ denotes cytosolic
T11005 3061-3062 NN denotes N
T11007 3062-3063 HYPH denotes -
T11008 3063-3071 JJ denotes terminal
T11009 3072-3073 -LRB- denotes (
T11010 3073-3078 NN denotes Cox11
T11012 3078-3079 HYPH denotes -
T11011 3079-3080 NN denotes C
T11013 3080-3081 -RRB- denotes )
T11014 3082-3095 RB denotes significantly
T11001 3096-3105 VBD denotes decreased
T11016 3106-3109 DT denotes the
T11017 3110-3121 NN denotes interaction
T11018 3122-3126 IN denotes with
T11019 3127-3129 NN denotes LD
T11020 3129-3131 , denotes ,
T11021 3131-3134 DT denotes the
T11023 3135-3148 JJ denotes mitochondrial
T11024 3149-3162 NN denotes intermembrane
T11022 3163-3169 NN denotes domain
T11025 3170-3172 IN denotes of
T11026 3173-3178 NN denotes Cox11
T11027 3179-3180 -LRB- denotes (
T11028 3180-3185 NN denotes Cox11
T11030 3185-3186 HYPH denotes -
T11029 3186-3187 NN denotes C
T11031 3187-3188 -RRB- denotes )
T11032 3189-3197 RB denotes together
T11033 3198-3202 IN denotes with
T11034 3203-3206 DT denotes the
T11036 3207-3208 NN denotes C
T11038 3208-3209 HYPH denotes -
T11037 3209-3217 JJ denotes terminal
T11035 3218-3222 NN denotes half
T11039 3223-3225 IN denotes of
T11040 3226-3228 NN denotes LD
T11041 3229-3230 -LRB- denotes (
T11042 3230-3232 NN denotes LD
T11044 3232-3233 HYPH denotes -
T11043 3233-3234 NN denotes C
T11045 3234-3235 -RRB- denotes )
T11015 3236-3244 VBD denotes retained
T11046 3245-3249 JJS denotes most
T11047 3250-3252 IN denotes of
T11048 3253-3256 DT denotes the
T11050 3257-3268 NN denotes interaction
T11049 3269-3277 NN denotes activity
T11051 3277-3278 . denotes .
T11052 3278-3350 sentence denotes LD-N and LD-C ended and began with the leucine zipper domain of RanBP2.
T11053 3279-3281 NN denotes LD
T11055 3281-3282 HYPH denotes -
T11054 3282-3283 NN denotes N
T11057 3284-3287 CC denotes and
T11058 3288-3290 NN denotes LD
T11060 3290-3291 HYPH denotes -
T11059 3291-3292 NN denotes C
T11056 3293-3298 VBD denotes ended
T11061 3299-3302 CC denotes and
T11062 3303-3308 VBD denotes began
T11063 3309-3313 IN denotes with
T11064 3314-3317 DT denotes the
T11066 3318-3325 NN denotes leucine
T11067 3326-3332 NN denotes zipper
T11065 3333-3339 NN denotes domain
T11068 3340-3342 IN denotes of
T11069 3343-3349 NN denotes RanBP2
T11070 3349-3350 . denotes .
T11071 3350-3462 sentence denotes White and black bars denote β-galactosidase activity and growth rates in selective growth medium, respectively.
T11072 3351-3356 JJ denotes White
T11074 3357-3360 CC denotes and
T11075 3361-3366 JJ denotes black
T11073 3367-3371 NNS denotes bars
T11076 3372-3378 VBP denotes denote
T11077 3379-3380 NN denotes β
T11079 3380-3381 HYPH denotes -
T11078 3381-3394 NN denotes galactosidase
T11080 3395-3403 NN denotes activity
T11081 3404-3407 CC denotes and
T11082 3408-3414 NN denotes growth
T11083 3415-3420 NNS denotes rates
T11084 3421-3423 IN denotes in
T11085 3424-3433 JJ denotes selective
T11087 3434-3440 NN denotes growth
T11086 3441-3447 NN denotes medium
T11088 3447-3449 , denotes ,
T11089 3449-3461 RB denotes respectively
T11090 3461-3462 . denotes .
T11091 3462-3508 sentence denotes Results shown represent the mean ± SD, n = 3.
T11092 3463-3470 NNS denotes Results
T11094 3471-3476 VBN denotes shown
T11093 3477-3486 VBP denotes represent
T11096 3487-3490 DT denotes the
T11098 3491-3495 NN denotes mean
T11099 3496-3497 SYM denotes ±
T11097 3498-3500 NN denotes SD
T11100 3500-3502 , denotes ,
T11101 3502-3503 NN denotes n
T11102 3504-3505 SYM denotes =
T11095 3506-3507 CD denotes 3
T11103 3507-3508 . denotes .
T11104 3508-3607 sentence denotes (D) GST pull-down assays with the LD of RanBP2 and its leucine zipper domain and retinal extracts.
T11105 3509-3510 -LRB- denotes (
T11106 3510-3511 LS denotes D
T11108 3511-3512 -RRB- denotes )
T11109 3513-3516 NN denotes GST
T11110 3517-3521 VB denotes pull
T11111 3521-3522 HYPH denotes -
T11112 3522-3526 RP denotes down
T11107 3527-3533 NNS denotes assays
T11113 3534-3538 IN denotes with
T11114 3539-3542 DT denotes the
T11115 3543-3545 NN denotes LD
T11116 3546-3548 IN denotes of
T11117 3549-3555 NN denotes RanBP2
T11118 3556-3559 CC denotes and
T11119 3560-3563 PRP$ denotes its
T11121 3564-3571 NN denotes leucine
T11122 3572-3578 NN denotes zipper
T11120 3579-3585 NN denotes domain
T11123 3586-3589 CC denotes and
T11124 3590-3597 JJ denotes retinal
T11125 3598-3606 NNS denotes extracts
T11126 3606-3607 . denotes .
T11127 3607-3733 sentence denotes The LD, but not the leucine zipper domain of RanBP2, associate with Cox11 (top panel, lane 1) and HKI (bottom panel, lane 1).
T11128 3608-3611 DT denotes The
T11129 3612-3614 NN denotes LD
T11131 3614-3616 , denotes ,
T11132 3616-3619 CC denotes but
T11133 3620-3623 RB denotes not
T11134 3624-3627 DT denotes the
T11136 3628-3635 NN denotes leucine
T11137 3636-3642 NN denotes zipper
T11135 3643-3649 NN denotes domain
T11138 3650-3652 IN denotes of
T11139 3653-3659 NN denotes RanBP2
T11140 3659-3661 , denotes ,
T11130 3661-3670 VBP denotes associate
T11141 3671-3675 IN denotes with
T11142 3676-3681 NN denotes Cox11
T11143 3682-3683 -LRB- denotes (
T11145 3683-3686 JJ denotes top
T11146 3687-3692 NN denotes panel
T11147 3692-3694 , denotes ,
T11144 3694-3698 NN denotes lane
T11148 3699-3700 CD denotes 1
T11149 3700-3701 -RRB- denotes )
T11150 3702-3705 CC denotes and
T11151 3706-3709 NN denotes HKI
T11152 3710-3711 -LRB- denotes (
T11154 3711-3717 JJ denotes bottom
T11155 3718-3723 NN denotes panel
T11156 3723-3725 , denotes ,
T11153 3725-3729 NN denotes lane
T11157 3730-3731 CD denotes 1
T11158 3731-3732 -RRB- denotes )
T11159 3732-3733 . denotes .
T11160 3733-3921 sentence denotes (E) Coimmunoprecipitation of RanBP2 with antibodies against its molecular partners shows that RanBP2 forms a complex in vivo with HKI (lanes 1 and 2), mHsp70 (lane 3), and Cox11 (lane 4).
T11161 3734-3735 -LRB- denotes (
T11162 3735-3736 LS denotes E
T11164 3736-3737 -RRB- denotes )
T11165 3738-3759 NN denotes Coimmunoprecipitation
T11166 3760-3762 IN denotes of
T11167 3763-3769 NN denotes RanBP2
T11168 3770-3774 IN denotes with
T11169 3775-3785 NNS denotes antibodies
T11170 3786-3793 IN denotes against
T11171 3794-3797 PRP$ denotes its
T11173 3798-3807 JJ denotes molecular
T11172 3808-3816 NNS denotes partners
T11163 3817-3822 VBZ denotes shows
T11174 3823-3827 IN denotes that
T11176 3828-3834 NN denotes RanBP2
T11175 3835-3840 VBZ denotes forms
T11177 3841-3842 DT denotes a
T11178 3843-3850 JJ denotes complex
T11179 3851-3853 FW denotes in
T11180 3854-3858 FW denotes vivo
T11181 3859-3863 IN denotes with
T11182 3864-3867 NN denotes HKI
T11183 3868-3869 -LRB- denotes (
T11185 3869-3874 NNS denotes lanes
T11184 3875-3876 CD denotes 1
T11186 3877-3880 CC denotes and
T11187 3881-3882 CD denotes 2
T11188 3882-3883 -RRB- denotes )
T11189 3883-3885 , denotes ,
T11190 3885-3891 NN denotes mHsp70
T11191 3892-3893 -LRB- denotes (
T11192 3893-3897 NN denotes lane
T11193 3898-3899 CD denotes 3
T11194 3899-3900 -RRB- denotes )
T11195 3900-3902 , denotes ,
T11196 3902-3905 CC denotes and
T11197 3906-3911 NN denotes Cox11
T11198 3912-3913 -LRB- denotes (
T11199 3913-3917 NN denotes lane
T11200 3918-3919 CD denotes 4
T11201 3919-3920 -RRB- denotes )
T11202 3920-3921 . denotes .
T11203 3921-4073 sentence denotes Lanes 5, 6, and 7 are control immunoprecipitation reactions with different antibodies against the RanBP2 domains, KBD, ZnF, and XAFXFG of nucleoporins.
T11204 3922-3927 NNS denotes Lanes
T11205 3928-3929 CD denotes 5
T11207 3929-3931 , denotes ,
T11208 3931-3932 CD denotes 6
T11209 3932-3934 , denotes ,
T11210 3934-3937 CC denotes and
T11211 3938-3939 CD denotes 7
T11206 3940-3943 VBP denotes are
T11212 3944-3951 NN denotes control
T11214 3952-3971 NN denotes immunoprecipitation
T11213 3972-3981 NNS denotes reactions
T11215 3982-3986 IN denotes with
T11216 3987-3996 JJ denotes different
T11217 3997-4007 NNS denotes antibodies
T11218 4008-4015 IN denotes against
T11219 4016-4019 DT denotes the
T11221 4020-4026 NN denotes RanBP2
T11220 4027-4034 NNS denotes domains
T11222 4034-4036 , denotes ,
T11223 4036-4039 NN denotes KBD
T11224 4039-4041 , denotes ,
T11225 4041-4044 NN denotes ZnF
T11226 4044-4046 , denotes ,
T11227 4046-4049 CC denotes and
T11228 4050-4056 NN denotes XAFXFG
T11229 4057-4059 IN denotes of
T11230 4060-4072 NNS denotes nucleoporins
T11231 4072-4073 . denotes .
T11232 4073-4173 sentence denotes (F) Reciprocal coimmunoprecipitation of HKI with antibodies against RanBP2 (used and shown in (E)).
T11233 4074-4075 -LRB- denotes (
T11234 4075-4076 LS denotes F
T11236 4076-4077 -RRB- denotes )
T11237 4078-4088 JJ denotes Reciprocal
T11235 4089-4110 NN denotes coimmunoprecipitation
T11238 4111-4113 IN denotes of
T11239 4114-4117 NN denotes HKI
T11240 4118-4122 IN denotes with
T11241 4123-4133 NNS denotes antibodies
T11242 4134-4141 IN denotes against
T11243 4142-4148 NN denotes RanBP2
T11244 4149-4150 -LRB- denotes (
T11245 4150-4154 VBN denotes used
T11246 4155-4158 CC denotes and
T11247 4159-4164 VBN denotes shown
T11248 4165-4167 IN denotes in
T11249 4168-4169 -LRB- denotes (
T11250 4169-4170 NN denotes E
T11251 4170-4171 -RRB- denotes )
T11252 4171-4172 -RRB- denotes )
T11253 4172-4173 . denotes .
T11254 4173-4450 sentence denotes (G) Reconstitution pull-down assays with purified LD and increasing concentrations of native (top panel), denatured (middle panel), and partially denatured (bottom panel) Cox11, respectively, in the absence and presence of denaturating agent, GnHCl and chaotropic agent, urea.
T11255 4174-4175 -LRB- denotes (
T11256 4175-4176 LS denotes G
T11258 4176-4177 -RRB- denotes )
T11259 4178-4192 NN denotes Reconstitution
T11260 4193-4197 VB denotes pull
T11261 4197-4198 HYPH denotes -
T11262 4198-4202 RP denotes down
T11257 4203-4209 NNS denotes assays
T11263 4210-4214 IN denotes with
T11264 4215-4223 VBN denotes purified
T11265 4224-4226 NN denotes LD
T11266 4227-4230 CC denotes and
T11267 4231-4241 VBG denotes increasing
T11268 4242-4256 NNS denotes concentrations
T11269 4257-4259 IN denotes of
T11270 4260-4266 JJ denotes native
T11272 4267-4268 -LRB- denotes (
T11274 4268-4271 JJ denotes top
T11273 4272-4277 NN denotes panel
T11275 4277-4278 -RRB- denotes )
T11276 4278-4280 , denotes ,
T11277 4280-4289 VBN denotes denatured
T11278 4290-4291 -LRB- denotes (
T11280 4291-4297 JJ denotes middle
T11279 4298-4303 NN denotes panel
T11281 4303-4304 -RRB- denotes )
T11282 4304-4306 , denotes ,
T11283 4306-4309 CC denotes and
T11284 4310-4319 RB denotes partially
T11285 4320-4329 VBN denotes denatured
T11286 4330-4331 -LRB- denotes (
T11288 4331-4337 JJ denotes bottom
T11287 4338-4343 NN denotes panel
T11289 4343-4344 -RRB- denotes )
T11271 4345-4350 NN denotes Cox11
T11290 4350-4352 , denotes ,
T11291 4352-4364 RB denotes respectively
T11292 4364-4366 , denotes ,
T11293 4366-4368 IN denotes in
T11294 4369-4372 DT denotes the
T11295 4373-4380 NN denotes absence
T11296 4381-4384 CC denotes and
T11297 4385-4393 NN denotes presence
T11298 4394-4396 IN denotes of
T11299 4397-4409 VBG denotes denaturating
T11300 4410-4415 NN denotes agent
T11301 4415-4417 , denotes ,
T11302 4417-4422 NN denotes GnHCl
T11303 4423-4426 CC denotes and
T11304 4427-4437 JJ denotes chaotropic
T11305 4438-4443 NN denotes agent
T11306 4443-4445 , denotes ,
T11307 4445-4449 NN denotes urea
T11308 4449-4450 . denotes .
T11309 4450-4557 sentence denotes Folding intermediates (lower panel) of Cox11 exhibit the highest binding activity toward the LD of RanBP2.
T11310 4451-4458 NN denotes Folding
T11311 4459-4472 NNS denotes intermediates
T11313 4473-4474 -LRB- denotes (
T11315 4474-4479 JJR denotes lower
T11314 4480-4485 NN denotes panel
T11316 4485-4486 -RRB- denotes )
T11317 4487-4489 IN denotes of
T11318 4490-4495 NN denotes Cox11
T11312 4496-4503 VBP denotes exhibit
T11319 4504-4507 DT denotes the
T11321 4508-4515 JJS denotes highest
T11322 4516-4523 NN denotes binding
T11320 4524-4532 NN denotes activity
T11323 4533-4539 IN denotes toward
T11324 4540-4543 DT denotes the
T11325 4544-4546 NN denotes LD
T11326 4547-4549 IN denotes of
T11327 4550-4556 NN denotes RanBP2
T11328 4556-4557 . denotes .
T11329 4557-4701 sentence denotes (H) Similar experiments as in (G) but in the presence of native Cox11 expressed in the absence (top panel) or presence (bottom panel) of CuSO4.
T11330 4558-4559 -LRB- denotes (
T11331 4559-4560 LS denotes H
T11333 4560-4561 -RRB- denotes )
T11334 4562-4569 JJ denotes Similar
T11332 4570-4581 NNS denotes experiments
T11335 4582-4584 IN denotes as
T11336 4585-4587 IN denotes in
T11337 4588-4589 -LRB- denotes (
T11338 4589-4590 NN denotes G
T11339 4590-4591 -RRB- denotes )
T11340 4592-4595 IN denotes but
T11341 4596-4598 IN denotes in
T11342 4599-4602 DT denotes the
T11343 4603-4611 NN denotes presence
T11344 4612-4614 IN denotes of
T11345 4615-4621 JJ denotes native
T11346 4622-4627 NN denotes Cox11
T11347 4628-4637 VBN denotes expressed
T11348 4638-4640 IN denotes in
T11349 4641-4644 DT denotes the
T11350 4645-4652 NN denotes absence
T11351 4653-4654 -LRB- denotes (
T11353 4654-4657 JJ denotes top
T11352 4658-4663 NN denotes panel
T11354 4663-4664 -RRB- denotes )
T11355 4665-4667 CC denotes or
T11356 4668-4676 NN denotes presence
T11357 4677-4678 -LRB- denotes (
T11359 4678-4684 JJ denotes bottom
T11358 4685-4690 NN denotes panel
T11360 4690-4691 -RRB- denotes )
T11361 4692-4694 IN denotes of
T11362 4695-4700 NN denotes CuSO4
T11363 4700-4701 . denotes .
T11364 4701-4795 sentence denotes The mature isoform of the metallochaperone has an increased affinity toward the LD of RanBP2.
T11365 4702-4705 DT denotes The
T11367 4706-4712 JJ denotes mature
T11366 4713-4720 NN denotes isoform
T11369 4721-4723 IN denotes of
T11370 4724-4727 DT denotes the
T11371 4728-4744 NN denotes metallochaperone
T11368 4745-4748 VBZ denotes has
T11372 4749-4751 DT denotes an
T11374 4752-4761 VBN denotes increased
T11373 4762-4770 NN denotes affinity
T11375 4771-4777 IN denotes toward
T11376 4778-4781 DT denotes the
T11377 4782-4784 NN denotes LD
T11378 4785-4787 IN denotes of
T11379 4788-4794 NN denotes RanBP2
T11380 4794-4795 . denotes .
T11381 4795-5038 sentence denotes LD, leucine-rich domain; LZ, leucine zipper domain; RBD1–4, Ran-binding domains 1–4; ZnF, zinc finger cluster domain; KBD, kinesin (KIF5B/KIF5C)-binding domain; CLD, cyclophilin-like domain; IR, internal repeat domain; CY, cyclophilin domain.
T11382 4796-4798 NN denotes LD
T11383 4798-4800 , denotes ,
T11384 4800-4807 NN denotes leucine
T11386 4807-4808 HYPH denotes -
T11385 4808-4812 JJ denotes rich
T11387 4813-4819 NN denotes domain
T11388 4819-4820 : denotes ;
T11389 4821-4823 NN denotes LZ
T11390 4823-4825 , denotes ,
T11391 4825-4832 NN denotes leucine
T11392 4833-4839 NN denotes zipper
T11393 4840-4846 NN denotes domain
T11394 4846-4847 : denotes ;
T11395 4848-4852 NN denotes RBD1
T11396 4852-4853 SYM denotes –
T11397 4853-4854 CD denotes 4
T11398 4854-4856 , denotes ,
T11399 4856-4859 NN denotes Ran
T11401 4859-4860 HYPH denotes -
T11400 4860-4867 NN denotes binding
T11402 4868-4875 NNS denotes domains
T11403 4876-4877 CD denotes 1
T11405 4877-4878 SYM denotes –
T11404 4878-4879 CD denotes 4
T11406 4879-4880 : denotes ;
T11407 4881-4884 NN denotes ZnF
T11408 4884-4886 , denotes ,
T11409 4886-4890 NN denotes zinc
T11410 4891-4897 NN denotes finger
T11412 4898-4905 NN denotes cluster
T11411 4906-4912 NN denotes domain
T11413 4912-4913 : denotes ;
T11414 4914-4917 NN denotes KBD
T11415 4917-4919 , denotes ,
T11416 4919-4926 NN denotes kinesin
T11418 4927-4928 -LRB- denotes (
T11419 4928-4933 NN denotes KIF5B
T11421 4933-4934 HYPH denotes /
T11420 4934-4939 NN denotes KIF5C
T11422 4939-4940 -RRB- denotes )
T11423 4940-4941 HYPH denotes -
T11417 4941-4948 NN denotes binding
T11424 4949-4955 NN denotes domain
T11425 4955-4956 : denotes ;
T11426 4957-4960 NN denotes CLD
T11427 4960-4962 , denotes ,
T11428 4962-4973 NN denotes cyclophilin
T11430 4973-4974 HYPH denotes -
T11429 4974-4978 JJ denotes like
T11431 4979-4985 NN denotes domain
T11432 4985-4986 : denotes ;
T11433 4987-4989 NN denotes IR
T11434 4989-4991 , denotes ,
T11435 4991-4999 JJ denotes internal
T11436 5000-5006 NN denotes repeat
T11437 5007-5013 NN denotes domain
T11438 5013-5014 : denotes ;
T11439 5015-5017 NN denotes CY
T11440 5017-5019 , denotes ,
T11441 5019-5030 NN denotes cyclophilin
T11442 5031-5037 NN denotes domain
T11443 5037-5038 . denotes .
R1179 T2102 T2103 det The,LD
R1180 T2103 T2104 nsubj LD,Interacts
R1181 T2105 T2103 prep of,LD
R1182 T2106 T2105 pobj RanBP2,of
R1183 T2107 T2104 prep with,Interacts
R1184 T2108 T2107 pobj Cox11,with
R1185 T2109 T2108 cc and,Cox11
R1186 T2110 T2108 conj HKI,Cox11
R1187 T2112 T2113 det The,LD
R1188 T2113 T2114 nsubj LD,is
R1189 T2115 T2113 prep of,LD
R1190 T2116 T2115 pobj RanBP2,of
R1191 T2117 T2118 punct (,1A
R1192 T2118 T2113 parataxis 1A,LD
R1193 T2119 T2118 compound Figure,1A
R1194 T2120 T2118 punct ),1A
R1195 T2121 T2122 det a,domain
R1196 T2122 T2114 attr domain,is
R1197 T2123 T2122 amod large,domain
R1198 T2124 T2123 cc and,large
R1199 T2125 T2123 conj orphan,large
R1200 T2126 T2122 prep of,domain
R1201 T2127 T2128 punct ~,700
R1202 T2128 T2129 nummod 700,residues
R1203 T2129 T2126 pobj residues,of
R1204 T2130 T2129 punct (,residues
R1205 T2131 T2132 punct ~,80
R1206 T2132 T2133 nummod 80,kDa
R1207 T2133 T2129 appos kDa,residues
R1208 T2134 T2122 punct ),domain
R1209 T2135 T2122 punct ", ",domain
R1210 T2136 T2137 prep for,identified
R1211 T2137 T2122 relcl identified,domain
R1212 T2138 T2136 pobj which,for
R1213 T2139 T2140 det no,partners
R1214 T2140 T2137 nsubjpass partners,identified
R1215 T2141 T2140 amod molecular,partners
R1216 T2142 T2137 aux have,identified
R1217 T2143 T2137 auxpass been,identified
R1218 T2144 T2137 prep until,identified
R1219 T2145 T2146 det this,date
R1220 T2146 T2144 pobj date,until
R1221 T2147 T2114 punct .,is
R1222 T2149 T2150 nmod Brain,libraries
R1223 T2150 T2157 nsubjpass libraries,screened
R1224 T2151 T2149 cc and,Brain
R1225 T2152 T2149 conj retina,Brain
R1226 T2153 T2150 nmod yeast,libraries
R1227 T2154 T2155 nummod two,hybrid
R1228 T2155 T2150 compound hybrid,libraries
R1229 T2156 T2155 punct -,hybrid
R1230 T2158 T2157 auxpass were,screened
R1231 T2159 T2157 prep with,screened
R1232 T2160 T2159 pobj LD,with
R1233 T2161 T2157 punct .,screened
R1234 T2163 T2164 nsubjpass Cox11,identified
R1235 T2165 T2164 auxpass was,identified
R1236 T2166 T2164 prep as,identified
R1237 T2167 T2168 det a,partner
R1238 T2168 T2166 pobj partner,as
R1239 T2169 T2168 prep to,partner
R1240 T2170 T2171 det this,domain
R1241 T2171 T2169 pobj domain,to
R1242 T2172 T2173 punct (,1B
R1243 T2173 T2164 parataxis 1B,identified
R1244 T2174 T2173 compound Figure,1B
R1245 T2175 T2173 cc and,1B
R1246 T2176 T2173 conj 1C,1B
R1247 T2177 T2173 punct ),1B
R1248 T2178 T2164 punct .,identified
R1249 T2180 T2181 nsubj Cox11,is
R1250 T2182 T2183 det a,metallochaperone
R1251 T2183 T2181 attr metallochaperone,is
R1252 T2184 T2183 acl implicated,metallochaperone
R1253 T2185 T2184 prep in,implicated
R1254 T2186 T2187 compound cytochrome,oxidase
R1255 T2187 T2189 compound oxidase,assembly
R1256 T2188 T2187 compound c,oxidase
R1257 T2189 T2185 pobj assembly,in
R1258 T2190 T2191 punct [,31
R1259 T2191 T2181 parataxis 31,is
R1260 T2192 T2191 nummod 30,31
R1261 T2193 T2191 punct ",",31
R1262 T2194 T2191 punct ],31
R1263 T2195 T2181 punct .,is
R1264 T2197 T2198 compound Structure,function
R1265 T2198 T2200 compound function,analysis
R1266 T2199 T2198 punct -,function
R1267 T2200 T2201 nsubj analysis,showed
R1268 T2202 T2200 prep of,analysis
R1269 T2203 T2204 det the,interaction
R1270 T2204 T2202 pobj interaction,of
R1271 T2205 T2204 prep between,interaction
R1272 T2206 T2205 pobj mCox11,between
R1273 T2207 T2206 punct ", ",mCox11
R1274 T2208 T2206 conj LD,mCox11
R1275 T2209 T2208 prep of,LD
R1276 T2210 T2209 pobj RanBP2,of
R1277 T2211 T2208 punct ", ",LD
R1278 T2212 T2208 cc and,LD
R1279 T2213 T2208 conj subdomains,LD
R1280 T2214 T2213 advmod thereof,subdomains
R1281 T2215 T2200 punct ", ",analysis
R1282 T2216 T2200 prep with,analysis
R1283 T2217 T2218 amod quantitative,assays
R1284 T2218 T2216 pobj assays,with
R1285 T2219 T2218 nmod yeast,assays
R1286 T2220 T2221 nummod two,hybrid
R1287 T2221 T2218 compound hybrid,assays
R1288 T2222 T2221 punct -,hybrid
R1289 T2223 T2224 punct [,32
R1290 T2224 T2200 parataxis 32,analysis
R1291 T2225 T2224 punct ],32
R1292 T2226 T2201 punct ", ",showed
R1293 T2227 T2228 amod optimal,interaction
R1294 T2228 T2201 dobj interaction,showed
R1295 T2229 T2228 prep between,interaction
R1296 T2230 T2231 det the,proteins
R1297 T2231 T2229 pobj proteins,between
R1298 T2232 T2231 amod intact,proteins
R1299 T2233 T2231 nmod LD,proteins
R1300 T2234 T2233 cc and,LD
R1301 T2235 T2233 conj Cox11,LD
R1302 T2236 T2237 punct (,1C
R1303 T2237 T2201 parataxis 1C,showed
R1304 T2238 T2237 compound Figure,1C
R1305 T2239 T2237 punct ),1C
R1306 T2240 T2201 punct .,showed
R1307 T2242 T2243 amod Pull,assays
R1308 T2243 T2246 nsubj assays,precipitates
R1309 T2244 T2242 punct -,Pull
R1310 T2245 T2242 prt down,Pull
R1311 T2247 T2243 prep of,assays
R1312 T2248 T2249 amod retinal,extracts
R1313 T2249 T2247 pobj extracts,of
R1314 T2250 T2243 prep with,assays
R1315 T2251 T2252 nmod glutathione,transferase
R1316 T2252 T2255 nmod transferase,LD
R1317 T2253 T2252 nmod S,transferase
R1318 T2254 T2252 punct -,transferase
R1319 T2255 T2250 pobj LD,with
R1320 T2256 T2252 punct (,transferase
R1321 T2257 T2252 appos GST,transferase
R1322 T2258 T2255 punct ),LD
R1323 T2259 T2255 punct -,LD
R1324 T2260 T2261 det a,isoform
R1325 T2261 T2246 dobj isoform,precipitates
R1326 T2262 T2263 compound sodium,sulfate
R1327 T2263 T2265 npadvmod sulfate,resistant
R1328 T2264 T2263 compound dodecyl,sulfate
R1329 T2265 T2261 amod resistant,isoform
R1330 T2266 T2265 punct -,resistant
R1331 T2267 T2261 compound dimer,isoform
R1332 T2268 T2261 prep of,isoform
R1333 T2269 T2268 pobj Cox11,of
R1334 T2270 T2271 punct (,panel
R1335 T2271 T2261 parataxis panel,isoform
R1336 T2272 T2273 compound Figure,1D
R1337 T2273 T2271 dep 1D,panel
R1338 T2274 T2271 punct ", ",panel
R1339 T2275 T2271 amod top,panel
R1340 T2276 T2271 punct ),panel
R1341 T2277 T2261 punct ", ",isoform
R1342 T2278 T2279 dep which,bind
R1343 T2279 T2261 relcl bind,isoform
R1344 T2280 T2279 aux does,bind
R1345 T2281 T2279 neg not,bind
R1346 T2282 T2279 prep to,bind
R1347 T2283 T2284 compound GST,LDZIP
R1348 T2284 T2282 pobj LDZIP,to
R1349 T2285 T2284 punct -,LDZIP
R1350 T2286 T2284 advmod alone,LDZIP
R1351 T2287 T2246 punct .,precipitates
R1352 T2289 T2290 prep In,found
R1353 T2291 T2289 pobj addition,In
R1354 T2292 T2291 prep to,addition
R1355 T2293 T2292 pobj Cox11,to
R1356 T2294 T2290 punct ", ",found
R1357 T2295 T2290 nsubj we,found
R1358 T2296 T2290 advmod also,found
R1359 T2297 T2298 mark that,associated
R1360 T2298 T2290 ccomp associated,found
R1361 T2299 T2300 amod other,components
R1362 T2300 T2298 nsubj components,associated
R1363 T2301 T2300 amod mitochondrial,components
R1364 T2302 T2303 amod such,as
R1365 T2303 T2300 prep as,components
R1366 T2304 T2305 det the,protein
R1367 T2305 T2303 pobj protein,as
R1368 T2306 T2307 amod outer,membrane
R1369 T2307 T2308 npadvmod membrane,associated
R1370 T2308 T2305 amod associated,protein
R1371 T2309 T2308 punct -,associated
R1372 T2310 T2305 punct ", ",protein
R1373 T2311 T2305 appos HKI,protein
R1374 T2312 T2313 punct [,33
R1375 T2313 T2311 parataxis 33,HKI
R1376 T2314 T2313 punct ],33
R1377 T2315 T2316 punct (,panel
R1378 T2316 T2311 parataxis panel,HKI
R1379 T2317 T2318 compound Figure,1D
R1380 T2318 T2316 dep 1D,panel
R1381 T2319 T2316 punct ", ",panel
R1382 T2320 T2316 amod bottom,panel
R1383 T2321 T2316 punct ),panel
R1384 T2322 T2311 cc and,HKI
R1385 T2323 T2311 conj mHsp70,HKI
R1386 T2324 T2325 punct (,data
R1387 T2325 T2323 meta data,mHsp70
R1388 T2326 T2325 amod unpublished,data
R1389 T2327 T2325 punct ),data
R1390 T2328 T2298 punct ", ",associated
R1391 T2329 T2298 prep with,associated
R1392 T2330 T2329 pobj LD,with
R1393 T2331 T2330 prep of,LD
R1394 T2332 T2331 pobj RanBP2,of
R1395 T2333 T2290 punct .,found
R1396 T2335 T2336 det This,association
R1397 T2336 T2337 nsubj association,was
R1398 T2338 T2339 advmod highly,specific
R1399 T2339 T2337 acomp specific,was
R1400 T2340 T2339 prep toward,specific
R1401 T2341 T2342 det the,isoform
R1402 T2342 T2340 pobj isoform,toward
R1403 T2343 T2342 compound HKI,isoform
R1404 T2344 T2337 punct ", ",was
R1405 T2345 T2346 mark because,interact
R1406 T2346 T2337 advcl interact,was
R1407 T2347 T2346 nsubj HKII,interact
R1408 T2348 T2347 punct ", ",HKII
R1409 T2349 T2347 conj HKIII,HKII
R1410 T2350 T2349 punct ", ",HKIII
R1411 T2351 T2349 cc and,HKIII
R1412 T2352 T2349 conj glucokinase,HKIII
R1413 T2353 T2346 aux did,interact
R1414 T2354 T2346 neg not,interact
R1415 T2355 T2346 prep with,interact
R1416 T2356 T2357 det the,LD
R1417 T2357 T2355 pobj LD,with
R1418 T2358 T2357 prep of,LD
R1419 T2359 T2358 pobj RanBP2,of
R1420 T2360 T2361 punct (,data
R1421 T2361 T2346 meta data,interact
R1422 T2362 T2361 amod unpublished,data
R1423 T2363 T2361 punct ),data
R1424 T2364 T2337 punct .,was
R1425 T2366 T2367 det The,interaction
R1426 T2367 T2368 nsubj interaction,occurred
R1427 T2369 T2367 prep of,interaction
R1428 T2370 T2369 pobj Cox11,of
R1429 T2371 T2370 punct ", ",Cox11
R1430 T2372 T2370 conj HKI,Cox11
R1431 T2373 T2372 punct ", ",HKI
R1432 T2374 T2372 cc and,HKI
R1433 T2375 T2372 conj mHsp70,HKI
R1434 T2376 T2367 prep with,interaction
R1435 T2377 T2376 pobj RanBP2,with
R1436 T2378 T2379 advmod in,vivo
R1437 T2379 T2368 advmod vivo,occurred
R1438 T2380 T2368 prep in,occurred
R1439 T2381 T2382 amod retinal,extracts
R1440 T2382 T2380 pobj extracts,in
R1441 T2383 T2368 punct ", ",occurred
R1442 T2384 T2385 mark since,coimmunoprecipitated
R1443 T2385 T2368 advcl coimmunoprecipitated,occurred
R1444 T2386 T2385 nsubj antibodies,coimmunoprecipitated
R1445 T2387 T2386 prep against,antibodies
R1446 T2388 T2389 det these,RanBP2
R1447 T2389 T2387 pobj RanBP2,against
R1448 T2390 T2389 cc and,RanBP2
R1449 T2391 T2385 dobj RanBP2,coimmunoprecipitated
R1450 T2392 T2393 punct (,1E
R1451 T2393 T2391 parataxis 1E,RanBP2
R1452 T2394 T2393 compound Figure,1E
R1453 T2395 T2393 punct ),1E
R1454 T2396 T2391 cc and,RanBP2
R1455 T2397 T2391 conj HKI,RanBP2
R1456 T2398 T2399 punct (,1F
R1457 T2399 T2397 parataxis 1F,HKI
R1458 T2400 T2399 compound Figure,1F
R1459 T2401 T2399 punct ),1F
R1460 T2402 T2385 punct ", ",coimmunoprecipitated
R1461 T2403 T2385 advmod respectively,coimmunoprecipitated
R1462 T2404 T2385 punct ", ",coimmunoprecipitated
R1463 T2405 T2385 cc and,coimmunoprecipitated
R1464 T2406 T2407 det these,interactions
R1465 T2407 T2408 nsubjpass interactions,observed
R1466 T2408 T2385 conj observed,coimmunoprecipitated
R1467 T2409 T2408 auxpass were,observed
R1468 T2410 T2408 prep across,observed
R1469 T2411 T2412 amod different,tissues
R1470 T2412 T2410 pobj tissues,across
R1471 T2413 T2414 punct (,S1
R1472 T2414 T2408 parataxis S1,observed
R1473 T2415 T2414 compound Figure,S1
R1474 T2416 T2414 punct ),S1
R1475 T2417 T2368 punct .,occurred
R1476 T2419 T2420 mark Since,exhibits
R1477 T2420 T2422 advcl exhibits,assessed
R1478 T2421 T2420 nsubj RanBP2,exhibits
R1479 T2423 T2424 compound chaperone,activity
R1480 T2424 T2420 dobj activity,exhibits
R1481 T2425 T2422 punct ", ",assessed
R1482 T2426 T2422 nsubj we,assessed
R1483 T2427 T2428 mark whether,was
R1484 T2428 T2422 ccomp was,assessed
R1485 T2429 T2430 det the,interaction
R1486 T2430 T2428 nsubj interaction,was
R1487 T2431 T2430 prep between,interaction
R1488 T2432 T2433 det the,LD
R1489 T2433 T2431 pobj LD,between
R1490 T2434 T2433 prep of,LD
R1491 T2435 T2434 pobj RanBP2,of
R1492 T2436 T2433 cc and,LD
R1493 T2437 T2433 conj Cox11,LD
R1494 T2438 T2428 acomp direct,was
R1495 T2439 T2440 cc and,activity
R1496 T2440 T2428 dep activity,was
R1497 T2441 T2440 det the,activity
R1498 T2442 T2440 compound chaperone,activity
R1499 T2443 T2440 prep of,activity
R1500 T2444 T2443 pobj LD,of
R1501 T2445 T2440 prep toward,activity
R1502 T2446 T2447 amod folding,species
R1503 T2447 T2445 pobj species,toward
R1504 T2448 T2447 prep of,species
R1505 T2449 T2448 pobj Cox11,of
R1506 T2450 T2422 punct .,assessed
R1507 T2452 T2453 compound Reconstitution,binding
R1508 T2453 T2454 compound binding,assays
R1509 T2454 T2455 nsubjpass assays,carried
R1510 T2456 T2455 auxpass were,carried
R1511 T2457 T2455 prt out,carried
R1512 T2458 T2455 prep between,carried
R1513 T2459 T2460 amod purified,LD
R1514 T2460 T2458 pobj LD,between
R1515 T2461 T2460 cc and,LD
R1516 T2462 T2460 conj Cox11,LD
R1517 T2463 T2462 punct ", ",Cox11
R1518 T2464 T2465 advmod fully,denatured
R1519 T2465 T2462 acl denatured,Cox11
R1520 T2466 T2464 cc and,fully
R1521 T2467 T2464 conj partially,fully
R1522 T2468 T2465 prep with,denatured
R1523 T2469 T2468 pobj GnHCl,with
R1524 T2470 T2469 cc and,GnHCl
R1525 T2471 T2469 conj urea,GnHCl
R1526 T2472 T2465 punct ", ",denatured
R1527 T2473 T2465 advmod respectively,denatured
R1528 T2474 T2462 punct ", ",Cox11
R1529 T2475 T2462 cc and,Cox11
R1530 T2476 T2477 amod native,Cox11
R1531 T2477 T2462 conj Cox11,Cox11
R1532 T2478 T2479 punct (,1G
R1533 T2479 T2477 parataxis 1G,Cox11
R1534 T2480 T2479 compound Figure,1G
R1535 T2481 T2479 cc and,1G
R1536 T2482 T2479 conj 1H,1G
R1537 T2483 T2479 punct ),1G
R1538 T2484 T2455 punct .,carried
R1539 T2486 T2487 amod Partial,denatured
R1540 T2487 T2488 amod denatured,Cox11
R1541 T2488 T2489 nsubj Cox11,exhibits
R1542 T2490 T2491 advmod significantly,higher
R1543 T2491 T2492 amod higher,affinity
R1544 T2492 T2489 dobj affinity,exhibits
R1545 T2493 T2491 cc and,higher
R1546 T2494 T2495 npadvmod concentration,dependent
R1547 T2495 T2491 conj dependent,higher
R1548 T2496 T2495 punct -,dependent
R1549 T2497 T2492 compound binding,affinity
R1550 T2498 T2492 prep toward,affinity
R1551 T2499 T2498 pobj LD,toward
R1552 T2500 T2489 prep compared,exhibits
R1553 T2501 T2500 prep with,compared
R1554 T2502 T2503 det the,Cox11
R1555 T2503 T2501 pobj Cox11,with
R1556 T2504 T2503 amod native,Cox11
R1557 T2505 T2504 cc and,native
R1558 T2506 T2507 advmod fully,denatured
R1559 T2507 T2504 conj denatured,native
R1560 T2508 T2509 punct (,1G
R1561 T2509 T2489 parataxis 1G,exhibits
R1562 T2510 T2509 compound Figure,1G
R1563 T2511 T2509 punct ),1G
R1564 T2512 T2489 punct .,exhibits
R1565 T2514 T2515 prep In,shows
R1566 T2516 T2514 pobj addition,In
R1567 T2517 T2515 punct ", ",shows
R1568 T2518 T2519 amod native,Cox11
R1569 T2519 T2515 nsubj Cox11,shows
R1570 T2520 T2519 acl purified,Cox11
R1571 T2521 T2520 prep upon,purified
R1572 T2522 T2521 pobj expression,upon
R1573 T2523 T2520 prep in,purified
R1574 T2524 T2525 det the,presence
R1575 T2525 T2523 pobj presence,in
R1576 T2526 T2525 prep of,presence
R1577 T2527 T2526 pobj CuSO4,of
R1578 T2528 T2527 punct (,CuSO4
R1579 T2529 T2530 det a,group
R1580 T2530 T2527 appos group,CuSO4
R1581 T2531 T2530 amod prosthetic,group
R1582 T2532 T2533 advmod tightly,bound
R1583 T2533 T2530 acl bound,group
R1584 T2534 T2533 prep to,bound
R1585 T2535 T2534 pobj Cox11,to
R1586 T2536 T2520 punct ),purified
R1587 T2537 T2538 punct [,31
R1588 T2538 T2520 parataxis 31,purified
R1589 T2539 T2538 punct ],31
R1590 T2540 T2515 punct ", ",shows
R1591 T2541 T2542 advmod significantly,higher
R1592 T2542 T2543 amod higher,activity
R1593 T2543 T2515 dobj activity,shows
R1594 T2544 T2543 compound binding,activity
R1595 T2545 T2543 prep toward,activity
R1596 T2546 T2547 det the,LD
R1597 T2547 T2545 pobj LD,toward
R1598 T2548 T2547 prep of,LD
R1599 T2549 T2548 pobj RanBP2,of
R1600 T2550 T2543 punct ", ",activity
R1601 T2551 T2543 prep than,activity
R1602 T2552 T2551 prep in,than
R1603 T2553 T2554 det the,absence
R1604 T2554 T2552 pobj absence,in
R1605 T2555 T2554 prep of,absence
R1606 T2556 T2555 pobj CuSO4,of
R1607 T2557 T2558 punct (,1H
R1608 T2558 T2515 parataxis 1H,shows
R1609 T2559 T2558 compound Figure,1H
R1610 T2560 T2558 punct ),1H
R1611 T2561 T2515 punct .,shows
R7150 T10852 T10853 det The,LD
R7151 T10853 T10854 nsubj LD,Interacts
R7152 T10855 T10853 prep of,LD
R7153 T10856 T10855 pobj RanBP2,of
R7154 T10857 T10854 prep with,Interacts
R7155 T10858 T10857 pobj Cox11,with
R7156 T10859 T10858 cc and,Cox11
R7157 T10860 T10858 conj HKI,Cox11
R7158 T10862 T10863 punct (,A
R7159 T10863 T10864 meta A,structure
R7160 T10865 T10863 punct ),A
R7161 T10866 T10864 amod Primary,structure
R7162 T10867 T10864 prep of,structure
R7163 T10868 T10867 pobj RanBP2,of
R7164 T10869 T10864 cc and,structure
R7165 T10870 T10871 poss its,domains
R7166 T10871 T10864 conj domains,structure
R7167 T10872 T10873 amod structural,functional
R7168 T10873 T10871 amod functional,domains
R7169 T10874 T10873 punct /,functional
R7170 T10875 T10871 punct .,domains
R7171 T10877 T10878 det The,LD
R7172 T10878 T10882 nsubjpass LD,underlined
R7173 T10879 T10880 npadvmod N,terminal
R7174 T10880 T10878 amod terminal,LD
R7175 T10881 T10880 punct -,terminal
R7176 T10883 T10878 prep of,LD
R7177 T10884 T10883 pobj RanBP2,of
R7178 T10885 T10882 auxpass is,underlined
R7179 T10886 T10882 punct .,underlined
R7180 T10888 T10889 punct (,B
R7181 T10889 T10890 meta B,alignment
R7182 T10891 T10889 punct ),B
R7183 T10892 T10890 compound Sequence,alignment
R7184 T10893 T10890 prep of,alignment
R7185 T10894 T10895 amod murine,Cox11
R7186 T10895 T10893 pobj Cox11,of
R7187 T10896 T10894 cc and,murine
R7188 T10897 T10894 conj yeast,murine
R7189 T10898 T10890 punct .,alignment
R7190 T10900 T10901 det The,domains
R7191 T10901 T10910 nsubjpass domains,conserved
R7192 T10902 T10901 nmod yeast,domains
R7193 T10903 T10901 nmod Cox11,domains
R7194 T10904 T10905 npadvmod C,terminal
R7195 T10905 T10901 amod terminal,domains
R7196 T10906 T10904 punct -,C
R7197 T10907 T10904 cc and,C
R7198 T10908 T10904 conj N,C
R7199 T10909 T10905 punct -,terminal
R7200 T10911 T10910 auxpass are,conserved
R7201 T10912 T10910 advmod poorly,conserved
R7202 T10913 T10910 punct .,conserved
R7203 T10915 T10916 nsubj Arrow,denote
R7204 T10917 T10915 cc and,Arrow
R7205 T10918 T10919 amod solid,line
R7206 T10919 T10915 conj line,Arrow
R7207 T10920 T10921 det the,site
R7208 T10921 T10916 dobj site,denote
R7209 T10922 T10921 amod predicted,site
R7210 T10923 T10924 amod mitochondrial,cleavage
R7211 T10924 T10921 compound cleavage,site
R7212 T10925 T10921 cc and,site
R7213 T10926 T10927 npadvmod membrane,spanning
R7214 T10927 T10929 amod spanning,domain
R7215 T10928 T10927 punct -,spanning
R7216 T10929 T10921 conj domain,site
R7217 T10930 T10916 punct .,denote
R7218 T10932 T10933 det The,lines
R7219 T10933 T10937 nsubj lines,represent
R7220 T10934 T10933 amod dotted,lines
R7221 T10935 T10934 cc and,dotted
R7222 T10936 T10934 conj dashed,dotted
R7223 T10938 T10933 prep above,lines
R7224 T10939 T10940 det the,sequences
R7225 T10940 T10938 pobj sequences,above
R7226 T10941 T10940 amod aligned,sequences
R7227 T10942 T10937 punct ", ",represent
R7228 T10943 T10937 advmod respectively,represent
R7229 T10944 T10937 punct ", ",represent
R7230 T10945 T10946 nmod Cox11,N
R7231 T10946 T10948 nmod N,constructs
R7232 T10947 T10946 punct -,N
R7233 T10948 T10937 dobj constructs,represent
R7234 T10949 T10946 cc and,N
R7235 T10950 T10951 compound Cox11,C
R7236 T10951 T10946 conj C,N
R7237 T10952 T10951 punct -,C
R7238 T10953 T10948 acl shown,constructs
R7239 T10954 T10953 prep in,shown
R7240 T10955 T10956 compound Figure,1C
R7241 T10956 T10954 pobj 1C,in
R7242 T10957 T10937 punct .,represent
R7243 T10959 T10960 punct (,C
R7244 T10960 T10961 meta C,analysis
R7245 T10962 T10960 punct ),C
R7246 T10963 T10964 compound Structure,function
R7247 T10964 T10961 compound function,analysis
R7248 T10965 T10964 punct -,function
R7249 T10966 T10961 prep of,analysis
R7250 T10967 T10968 det the,interaction
R7251 T10968 T10966 pobj interaction,of
R7252 T10969 T10968 prep between,interaction
R7253 T10970 T10971 det the,LD
R7254 T10971 T10969 pobj LD,between
R7255 T10972 T10971 prep of,LD
R7256 T10973 T10972 pobj RanBP2,of
R7257 T10974 T10971 cc and,LD
R7258 T10975 T10971 conj Cox11,LD
R7259 T10976 T10961 punct .,analysis
R7260 T10978 T10979 amod Optimal,interaction
R7261 T10979 T10980 nsubj interaction,occurred
R7262 T10981 T10979 prep between,interaction
R7263 T10982 T10983 det the,LD
R7264 T10983 T10981 pobj LD,between
R7265 T10984 T10983 cc and,LD
R7266 T10985 T10983 conj Cox11,LD
R7267 T10986 T10980 prep in,occurred
R7268 T10987 T10988 det the,presence
R7269 T10988 T10986 pobj presence,in
R7270 T10989 T10988 prep of,presence
R7271 T10990 T10989 pobj constructs,of
R7272 T10991 T10990 acl comprising,constructs
R7273 T10992 T10993 preconj both,LD
R7274 T10993 T10991 dobj LD,comprising
R7275 T10994 T10993 det the,LD
R7276 T10995 T10993 amod complete,LD
R7277 T10996 T10993 cc and,LD
R7278 T10997 T10993 conj Cox11,LD
R7279 T10998 T10980 punct .,occurred
R7280 T11000 T11001 mark Although,decreased
R7281 T11001 T11015 advcl decreased,retained
R7282 T11002 T11001 nsubj removal,decreased
R7283 T11003 T11002 prep of,removal
R7284 T11004 T11005 det the,N
R7285 T11005 T11003 pobj N,of
R7286 T11006 T11005 amod cytosolic,N
R7287 T11007 T11005 punct -,N
R7288 T11008 T11005 amod terminal,N
R7289 T11009 T11002 punct (,removal
R7290 T11010 T11011 compound Cox11,C
R7291 T11011 T11002 appos C,removal
R7292 T11012 T11011 punct -,C
R7293 T11013 T11001 punct ),decreased
R7294 T11014 T11001 advmod significantly,decreased
R7295 T11016 T11017 det the,interaction
R7296 T11017 T11001 dobj interaction,decreased
R7297 T11018 T11017 prep with,interaction
R7298 T11019 T11018 pobj LD,with
R7299 T11020 T11015 punct ", ",retained
R7300 T11021 T11022 det the,domain
R7301 T11022 T11015 nsubj domain,retained
R7302 T11023 T11022 amod mitochondrial,domain
R7303 T11024 T11022 compound intermembrane,domain
R7304 T11025 T11022 prep of,domain
R7305 T11026 T11025 pobj Cox11,of
R7306 T11027 T11022 punct (,domain
R7307 T11028 T11029 compound Cox11,C
R7308 T11029 T11022 appos C,domain
R7309 T11030 T11029 punct -,C
R7310 T11031 T11022 punct ),domain
R7311 T11032 T11022 advmod together,domain
R7312 T11033 T11032 prep with,together
R7313 T11034 T11035 det the,half
R7314 T11035 T11033 pobj half,with
R7315 T11036 T11037 npadvmod C,terminal
R7316 T11037 T11035 amod terminal,half
R7317 T11038 T11037 punct -,terminal
R7318 T11039 T11035 prep of,half
R7319 T11040 T11039 pobj LD,of
R7320 T11041 T11035 punct (,half
R7321 T11042 T11043 compound LD,C
R7322 T11043 T11035 appos C,half
R7323 T11044 T11043 punct -,C
R7324 T11045 T11015 punct ),retained
R7325 T11046 T11015 dobj most,retained
R7326 T11047 T11046 prep of,most
R7327 T11048 T11049 det the,activity
R7328 T11049 T11047 pobj activity,of
R7329 T11050 T11049 compound interaction,activity
R7330 T11051 T11015 punct .,retained
R7331 T11053 T11054 compound LD,N
R7332 T11054 T11056 nsubj N,ended
R7333 T11055 T11054 punct -,N
R7334 T11057 T11054 cc and,N
R7335 T11058 T11059 compound LD,C
R7336 T11059 T11054 conj C,N
R7337 T11060 T11059 punct -,C
R7338 T11061 T11056 cc and,ended
R7339 T11062 T11056 conj began,ended
R7340 T11063 T11062 prep with,began
R7341 T11064 T11065 det the,domain
R7342 T11065 T11063 pobj domain,with
R7343 T11066 T11067 compound leucine,zipper
R7344 T11067 T11065 compound zipper,domain
R7345 T11068 T11065 prep of,domain
R7346 T11069 T11068 pobj RanBP2,of
R7347 T11070 T11056 punct .,ended
R7348 T11072 T11073 amod White,bars
R7349 T11073 T11076 nsubj bars,denote
R7350 T11074 T11072 cc and,White
R7351 T11075 T11072 conj black,White
R7352 T11077 T11078 compound β,galactosidase
R7353 T11078 T11080 compound galactosidase,activity
R7354 T11079 T11078 punct -,galactosidase
R7355 T11080 T11076 dobj activity,denote
R7356 T11081 T11080 cc and,activity
R7357 T11082 T11083 compound growth,rates
R7358 T11083 T11080 conj rates,activity
R7359 T11084 T11083 prep in,rates
R7360 T11085 T11086 amod selective,medium
R7361 T11086 T11084 pobj medium,in
R7362 T11087 T11086 compound growth,medium
R7363 T11088 T11076 punct ", ",denote
R7364 T11089 T11076 advmod respectively,denote
R7365 T11090 T11076 punct .,denote
R7366 T11092 T11093 nsubj Results,represent
R7367 T11093 T11095 ccomp represent,3
R7368 T11094 T11092 acl shown,Results
R7369 T11096 T11097 det the,SD
R7370 T11097 T11093 dobj SD,represent
R7371 T11098 T11097 nmod mean,SD
R7372 T11099 T11097 punct ±,SD
R7373 T11100 T11095 punct ", ",3
R7374 T11101 T11095 nsubj n,3
R7375 T11102 T11095 punct =,3
R7376 T11103 T11095 punct .,3
R7377 T11105 T11106 punct (,D
R7378 T11106 T11107 meta D,assays
R7379 T11108 T11106 punct ),D
R7380 T11109 T11107 nmod GST,assays
R7381 T11110 T11107 amod pull,assays
R7382 T11111 T11110 punct -,pull
R7383 T11112 T11110 prt down,pull
R7384 T11113 T11107 prep with,assays
R7385 T11114 T11115 det the,LD
R7386 T11115 T11113 pobj LD,with
R7387 T11116 T11115 prep of,LD
R7388 T11117 T11116 pobj RanBP2,of
R7389 T11118 T11115 cc and,LD
R7390 T11119 T11120 poss its,domain
R7391 T11120 T11115 conj domain,LD
R7392 T11121 T11122 compound leucine,zipper
R7393 T11122 T11120 compound zipper,domain
R7394 T11123 T11120 cc and,domain
R7395 T11124 T11125 amod retinal,extracts
R7396 T11125 T11120 conj extracts,domain
R7397 T11126 T11107 punct .,assays
R7398 T11128 T11129 det The,LD
R7399 T11129 T11130 nsubj LD,associate
R7400 T11131 T11129 punct ", ",LD
R7401 T11132 T11129 cc but,LD
R7402 T11133 T11132 neg not,but
R7403 T11134 T11135 det the,domain
R7404 T11135 T11129 conj domain,LD
R7405 T11136 T11137 compound leucine,zipper
R7406 T11137 T11135 compound zipper,domain
R7407 T11138 T11129 prep of,LD
R7408 T11139 T11138 pobj RanBP2,of
R7409 T11140 T11130 punct ", ",associate
R7410 T11141 T11130 prep with,associate
R7411 T11142 T11141 pobj Cox11,with
R7412 T11143 T11144 punct (,lane
R7413 T11144 T11142 parataxis lane,Cox11
R7414 T11145 T11146 amod top,panel
R7415 T11146 T11144 dep panel,lane
R7416 T11147 T11144 punct ", ",lane
R7417 T11148 T11144 nummod 1,lane
R7418 T11149 T11144 punct ),lane
R7419 T11150 T11142 cc and,Cox11
R7420 T11151 T11142 conj HKI,Cox11
R7421 T11152 T11153 punct (,lane
R7422 T11153 T11151 parataxis lane,HKI
R7423 T11154 T11155 amod bottom,panel
R7424 T11155 T11153 dep panel,lane
R7425 T11156 T11153 punct ", ",lane
R7426 T11157 T11153 nummod 1,lane
R7427 T11158 T11153 punct ),lane
R7428 T11159 T11130 punct .,associate
R7429 T11161 T11162 punct (,E
R7430 T11162 T11163 meta E,shows
R7431 T11164 T11162 punct ),E
R7432 T11165 T11163 nsubj Coimmunoprecipitation,shows
R7433 T11166 T11165 prep of,Coimmunoprecipitation
R7434 T11167 T11166 pobj RanBP2,of
R7435 T11168 T11165 prep with,Coimmunoprecipitation
R7436 T11169 T11168 pobj antibodies,with
R7437 T11170 T11169 prep against,antibodies
R7438 T11171 T11172 poss its,partners
R7439 T11172 T11170 pobj partners,against
R7440 T11173 T11172 amod molecular,partners
R7441 T11174 T11175 mark that,forms
R7442 T11175 T11163 ccomp forms,shows
R7443 T11176 T11175 nsubj RanBP2,forms
R7444 T11177 T11178 det a,complex
R7445 T11178 T11175 dobj complex,forms
R7446 T11179 T11180 advmod in,vivo
R7447 T11180 T11175 advmod vivo,forms
R7448 T11181 T11175 prep with,forms
R7449 T11182 T11181 pobj HKI,with
R7450 T11183 T11184 punct (,1
R7451 T11184 T11182 parataxis 1,HKI
R7452 T11185 T11184 nmod lanes,1
R7453 T11186 T11184 cc and,1
R7454 T11187 T11184 conj 2,1
R7455 T11188 T11184 punct ),1
R7456 T11189 T11182 punct ", ",HKI
R7457 T11190 T11182 conj mHsp70,HKI
R7458 T11191 T11192 punct (,lane
R7459 T11192 T11190 parataxis lane,mHsp70
R7460 T11193 T11192 nummod 3,lane
R7461 T11194 T11192 punct ),lane
R7462 T11195 T11190 punct ", ",mHsp70
R7463 T11196 T11190 cc and,mHsp70
R7464 T11197 T11190 conj Cox11,mHsp70
R7465 T11198 T11199 punct (,lane
R7466 T11199 T11197 parataxis lane,Cox11
R7467 T11200 T11199 nummod 4,lane
R7468 T11201 T11199 punct ),lane
R7469 T11202 T11163 punct .,shows
R7470 T11204 T11205 nmod Lanes,5
R7471 T11205 T11206 nsubj 5,are
R7472 T11207 T11205 punct ", ",5
R7473 T11208 T11205 conj 6,5
R7474 T11209 T11208 punct ", ",6
R7475 T11210 T11208 cc and,6
R7476 T11211 T11208 conj 7,6
R7477 T11212 T11213 compound control,reactions
R7478 T11213 T11206 attr reactions,are
R7479 T11214 T11213 compound immunoprecipitation,reactions
R7480 T11215 T11213 prep with,reactions
R7481 T11216 T11217 amod different,antibodies
R7482 T11217 T11215 pobj antibodies,with
R7483 T11218 T11217 prep against,antibodies
R7484 T11219 T11220 det the,domains
R7485 T11220 T11218 pobj domains,against
R7486 T11221 T11220 compound RanBP2,domains
R7487 T11222 T11220 punct ", ",domains
R7488 T11223 T11220 appos KBD,domains
R7489 T11224 T11223 punct ", ",KBD
R7490 T11225 T11223 conj ZnF,KBD
R7491 T11226 T11225 punct ", ",ZnF
R7492 T11227 T11225 cc and,ZnF
R7493 T11228 T11225 conj XAFXFG,ZnF
R7494 T11229 T11220 prep of,domains
R7495 T11230 T11229 pobj nucleoporins,of
R7496 T11231 T11206 punct .,are
R7497 T11233 T11234 punct (,F
R7498 T11234 T11235 meta F,coimmunoprecipitation
R7499 T11236 T11234 punct ),F
R7500 T11237 T11235 amod Reciprocal,coimmunoprecipitation
R7501 T11238 T11235 prep of,coimmunoprecipitation
R7502 T11239 T11238 pobj HKI,of
R7503 T11240 T11235 prep with,coimmunoprecipitation
R7504 T11241 T11240 pobj antibodies,with
R7505 T11242 T11241 prep against,antibodies
R7506 T11243 T11242 pobj RanBP2,against
R7507 T11244 T11241 punct (,antibodies
R7508 T11245 T11241 acl used,antibodies
R7509 T11246 T11245 cc and,used
R7510 T11247 T11245 conj shown,used
R7511 T11248 T11247 prep in,shown
R7512 T11249 T11248 punct (,in
R7513 T11250 T11248 pobj E,in
R7514 T11251 T11235 punct ),coimmunoprecipitation
R7515 T11252 T11235 punct ),coimmunoprecipitation
R7516 T11253 T11235 punct .,coimmunoprecipitation
R7517 T11255 T11256 punct (,G
R7518 T11256 T11257 meta G,assays
R7519 T11258 T11256 punct ),G
R7520 T11259 T11257 nmod Reconstitution,assays
R7521 T11260 T11257 amod pull,assays
R7522 T11261 T11260 punct -,pull
R7523 T11262 T11260 prt down,pull
R7524 T11263 T11257 prep with,assays
R7525 T11264 T11265 amod purified,LD
R7526 T11265 T11263 pobj LD,with
R7527 T11266 T11265 cc and,LD
R7528 T11267 T11268 amod increasing,concentrations
R7529 T11268 T11265 conj concentrations,LD
R7530 T11269 T11268 prep of,concentrations
R7531 T11270 T11271 amod native,Cox11
R7532 T11271 T11269 pobj Cox11,of
R7533 T11272 T11273 punct (,panel
R7534 T11273 T11270 parataxis panel,native
R7535 T11274 T11273 amod top,panel
R7536 T11275 T11273 punct ),panel
R7537 T11276 T11270 punct ", ",native
R7538 T11277 T11270 conj denatured,native
R7539 T11278 T11279 punct (,panel
R7540 T11279 T11277 parataxis panel,denatured
R7541 T11280 T11279 amod middle,panel
R7542 T11281 T11279 punct ),panel
R7543 T11282 T11277 punct ", ",denatured
R7544 T11283 T11277 cc and,denatured
R7545 T11284 T11285 advmod partially,denatured
R7546 T11285 T11277 conj denatured,denatured
R7547 T11286 T11287 punct (,panel
R7548 T11287 T11285 parataxis panel,denatured
R7549 T11288 T11287 amod bottom,panel
R7550 T11289 T11287 punct ),panel
R7551 T11290 T11268 punct ", ",concentrations
R7552 T11291 T11268 advmod respectively,concentrations
R7553 T11292 T11257 punct ", ",assays
R7554 T11293 T11257 prep in,assays
R7555 T11294 T11295 det the,absence
R7556 T11295 T11293 pobj absence,in
R7557 T11296 T11295 cc and,absence
R7558 T11297 T11295 conj presence,absence
R7559 T11298 T11295 prep of,absence
R7560 T11299 T11300 amod denaturating,agent
R7561 T11300 T11298 pobj agent,of
R7562 T11301 T11300 punct ", ",agent
R7563 T11302 T11300 appos GnHCl,agent
R7564 T11303 T11300 cc and,agent
R7565 T11304 T11305 amod chaotropic,agent
R7566 T11305 T11300 conj agent,agent
R7567 T11306 T11305 punct ", ",agent
R7568 T11307 T11305 appos urea,agent
R7569 T11308 T11257 punct .,assays
R7570 T11310 T11311 compound Folding,intermediates
R7571 T11311 T11312 nsubj intermediates,exhibit
R7572 T11313 T11314 punct (,panel
R7573 T11314 T11311 parataxis panel,intermediates
R7574 T11315 T11314 amod lower,panel
R7575 T11316 T11314 punct ),panel
R7576 T11317 T11311 prep of,intermediates
R7577 T11318 T11317 pobj Cox11,of
R7578 T11319 T11320 det the,activity
R7579 T11320 T11312 dobj activity,exhibit
R7580 T11321 T11320 amod highest,activity
R7581 T11322 T11320 compound binding,activity
R7582 T11323 T11320 prep toward,activity
R7583 T11324 T11325 det the,LD
R7584 T11325 T11323 pobj LD,toward
R7585 T11326 T11325 prep of,LD
R7586 T11327 T11326 pobj RanBP2,of
R7587 T11328 T11312 punct .,exhibit
R7588 T11330 T11331 punct (,H
R7589 T11331 T11332 meta H,experiments
R7590 T11333 T11331 punct ),H
R7591 T11334 T11332 amod Similar,experiments
R7592 T11335 T11332 prep as,experiments
R7593 T11336 T11335 prep in,as
R7594 T11337 T11336 punct (,in
R7595 T11338 T11336 pobj G,in
R7596 T11339 T11332 punct ),experiments
R7597 T11340 T11332 prep but,experiments
R7598 T11341 T11340 prep in,but
R7599 T11342 T11343 det the,presence
R7600 T11343 T11341 pobj presence,in
R7601 T11344 T11343 prep of,presence
R7602 T11345 T11346 amod native,Cox11
R7603 T11346 T11344 pobj Cox11,of
R7604 T11347 T11346 acl expressed,Cox11
R7605 T11348 T11347 prep in,expressed
R7606 T11349 T11350 det the,absence
R7607 T11350 T11348 pobj absence,in
R7608 T11351 T11352 punct (,panel
R7609 T11352 T11350 parataxis panel,absence
R7610 T11353 T11352 amod top,panel
R7611 T11354 T11352 punct ),panel
R7612 T11355 T11350 cc or,absence
R7613 T11356 T11350 conj presence,absence
R7614 T11357 T11358 punct (,panel
R7615 T11358 T11356 parataxis panel,presence
R7616 T11359 T11358 amod bottom,panel
R7617 T11360 T11358 punct ),panel
R7618 T11361 T11350 prep of,absence
R7619 T11362 T11361 pobj CuSO4,of
R7620 T11363 T11332 punct .,experiments
R7621 T11365 T11366 det The,isoform
R7622 T11366 T11368 nsubj isoform,has
R7623 T11367 T11366 amod mature,isoform
R7624 T11369 T11366 prep of,isoform
R7625 T11370 T11371 det the,metallochaperone
R7626 T11371 T11369 pobj metallochaperone,of
R7627 T11372 T11373 det an,affinity
R7628 T11373 T11368 dobj affinity,has
R7629 T11374 T11373 amod increased,affinity
R7630 T11375 T11373 prep toward,affinity
R7631 T11376 T11377 det the,LD
R7632 T11377 T11375 pobj LD,toward
R7633 T11378 T11377 prep of,LD
R7634 T11379 T11378 pobj RanBP2,of
R7635 T11380 T11368 punct .,has
R7636 T11383 T11382 punct ", ",LD
R7637 T11384 T11385 npadvmod leucine,rich
R7638 T11385 T11387 amod rich,domain
R7639 T11386 T11385 punct -,rich
R7640 T11387 T11382 appos domain,LD
R7641 T11388 T11382 punct ;,LD
R7642 T11389 T11382 appos LZ,LD
R7643 T11390 T11389 punct ", ",LZ
R7644 T11391 T11392 compound leucine,zipper
R7645 T11392 T11393 compound zipper,domain
R7646 T11393 T11389 appos domain,LZ
R7647 T11394 T11382 punct ;,LD
R7648 T11395 T11382 appos RBD1,LD
R7649 T11396 T11397 punct –,4
R7650 T11397 T11395 prep 4,RBD1
R7651 T11398 T11395 punct ", ",RBD1
R7652 T11399 T11400 compound Ran,binding
R7653 T11400 T11402 compound binding,domains
R7654 T11401 T11400 punct -,binding
R7655 T11402 T11395 appos domains,RBD1
R7656 T11403 T11404 quantmod 1,4
R7657 T11404 T11402 npadvmod 4,domains
R7658 T11405 T11404 punct –,4
R7659 T11406 T11382 punct ;,LD
R7660 T11407 T11382 appos ZnF,LD
R7661 T11408 T11407 punct ", ",ZnF
R7662 T11409 T11410 compound zinc,finger
R7663 T11410 T11411 compound finger,domain
R7664 T11411 T11407 appos domain,ZnF
R7665 T11412 T11411 compound cluster,domain
R7666 T11413 T11382 punct ;,LD
R7667 T11414 T11382 appos KBD,LD
R7668 T11415 T11414 punct ", ",KBD
R7669 T11416 T11417 nmod kinesin,binding
R7670 T11417 T11424 compound binding,domain
R7671 T11418 T11416 punct (,kinesin
R7672 T11419 T11420 compound KIF5B,KIF5C
R7673 T11420 T11416 appos KIF5C,kinesin
R7674 T11421 T11420 punct /,KIF5C
R7675 T11422 T11417 punct ),binding
R7676 T11423 T11417 punct -,binding
R7677 T11424 T11414 appos domain,KBD
R7678 T11425 T11382 punct ;,LD
R7679 T11426 T11382 appos CLD,LD
R7680 T11427 T11426 punct ", ",CLD
R7681 T11428 T11429 npadvmod cyclophilin,like
R7682 T11429 T11431 amod like,domain
R7683 T11430 T11429 punct -,like
R7684 T11431 T11426 appos domain,CLD
R7685 T11432 T11382 punct ;,LD
R7686 T11433 T11382 appos IR,LD
R7687 T11434 T11433 punct ", ",IR
R7688 T11435 T11436 amod internal,repeat
R7689 T11436 T11437 compound repeat,domain
R7690 T11437 T11433 appos domain,IR
R7691 T11438 T11382 punct ;,LD
R7692 T11439 T11382 appos CY,LD
R7693 T11440 T11439 punct ", ",CY
R7694 T11441 T11442 compound cyclophilin,domain
R7695 T11442 T11439 appos domain,CY
R7696 T11443 T11382 punct .,LD