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PMC:1626108 / 7771-31395 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2102 9-12 DT denotes The
T2103 13-15 NN denotes LD
T2105 16-18 IN denotes of
T2106 19-25 NN denotes RanBP2
T2104 26-35 VBZ denotes Interacts
T2107 36-40 IN denotes with
T2108 41-46 NN denotes Cox11
T2109 47-50 CC denotes and
T2110 51-54 NN denotes HKI
T2111 54-210 sentence denotes The LD of RanBP2 (Figure 1A) is a large and orphan domain of ~700 residues (~80 kDa), for which no molecular partners have been identified until this date.
T2112 55-58 DT denotes The
T2113 59-61 NN denotes LD
T2115 62-64 IN denotes of
T2116 65-71 NN denotes RanBP2
T2117 72-73 -LRB- denotes (
T2119 73-79 NN denotes Figure
T2118 80-82 NN denotes 1A
T2120 82-83 -RRB- denotes )
T2114 84-86 VBZ denotes is
T2121 87-88 DT denotes a
T2123 89-94 JJ denotes large
T2124 95-98 CC denotes and
T2125 99-105 NN denotes orphan
T2122 106-112 NN denotes domain
T2126 113-115 IN denotes of
T2127 116-117 SYM denotes ~
T2128 117-120 CD denotes 700
T2129 121-129 NNS denotes residues
T2130 130-131 -LRB- denotes (
T2131 131-132 SYM denotes ~
T2132 132-134 CD denotes 80
T2133 135-138 NN denotes kDa
T2134 138-139 -RRB- denotes )
T2135 139-141 , denotes ,
T2136 141-144 IN denotes for
T2138 145-150 WDT denotes which
T2139 151-153 DT denotes no
T2141 154-163 JJ denotes molecular
T2140 164-172 NNS denotes partners
T2142 173-177 VBP denotes have
T2143 178-182 VBN denotes been
T2137 183-193 VBN denotes identified
T2144 194-199 IN denotes until
T2145 200-204 DT denotes this
T2146 205-209 NN denotes date
T2147 209-210 . denotes .
T2148 210-277 sentence denotes Brain and retina yeast two-hybrid libraries were screened with LD.
T2149 211-216 NN denotes Brain
T2151 217-220 CC denotes and
T2152 221-227 NN denotes retina
T2153 228-233 NN denotes yeast
T2154 234-237 CD denotes two
T2156 237-238 HYPH denotes -
T2155 238-244 NN denotes hybrid
T2150 245-254 NNS denotes libraries
T2158 255-259 VBD denotes were
T2157 260-268 VBN denotes screened
T2159 269-273 IN denotes with
T2160 274-276 NN denotes LD
T2161 276-277 . denotes .
T2162 277-346 sentence denotes Cox11 was identified as a partner to this domain (Figure 1B and 1C).
T2163 278-283 NN denotes Cox11
T2165 284-287 VBD denotes was
T2164 288-298 VBN denotes identified
T2166 299-301 IN denotes as
T2167 302-303 DT denotes a
T2168 304-311 NN denotes partner
T2169 312-314 IN denotes to
T2170 315-319 DT denotes this
T2171 320-326 NN denotes domain
T2172 327-328 -LRB- denotes (
T2174 328-334 NN denotes Figure
T2173 335-337 NN denotes 1B
T2175 338-341 CC denotes and
T2176 342-344 NN denotes 1C
T2177 344-345 -RRB- denotes )
T2178 345-346 . denotes .
T2179 346-427 sentence denotes Cox11 is a metallochaperone implicated in cytochrome c oxidase assembly [30,31].
T2180 347-352 NN denotes Cox11
T2181 353-355 VBZ denotes is
T2182 356-357 DT denotes a
T2183 358-374 NN denotes metallochaperone
T2184 375-385 VBN denotes implicated
T2185 386-388 IN denotes in
T2186 389-399 NN denotes cytochrome
T2188 400-401 NN denotes c
T2187 402-409 NN denotes oxidase
T2189 410-418 NN denotes assembly
T2190 419-420 -LRB- denotes [
T2192 420-422 CD denotes 30
T2193 422-423 , denotes ,
T2191 423-425 CD denotes 31
T2194 425-426 -RRB- denotes ]
T2195 426-427 . denotes .
T2196 427-657 sentence denotes Structure-function analysis of the interaction between mCox11, LD of RanBP2, and subdomains thereof, with quantitative yeast two-hybrid assays [32], showed optimal interaction between the intact LD and Cox11 proteins (Figure 1C).
T2197 428-437 NN denotes Structure
T2199 437-438 HYPH denotes -
T2198 438-446 NN denotes function
T2200 447-455 NN denotes analysis
T2202 456-458 IN denotes of
T2203 459-462 DT denotes the
T2204 463-474 NN denotes interaction
T2205 475-482 IN denotes between
T2206 483-489 NN denotes mCox11
T2207 489-491 , denotes ,
T2208 491-493 NN denotes LD
T2209 494-496 IN denotes of
T2210 497-503 NN denotes RanBP2
T2211 503-505 , denotes ,
T2212 505-508 CC denotes and
T2213 509-519 NNS denotes subdomains
T2214 520-527 RB denotes thereof
T2215 527-529 , denotes ,
T2216 529-533 IN denotes with
T2217 534-546 JJ denotes quantitative
T2219 547-552 NN denotes yeast
T2220 553-556 CD denotes two
T2222 556-557 HYPH denotes -
T2221 557-563 NN denotes hybrid
T2218 564-570 NNS denotes assays
T2223 571-572 -LRB- denotes [
T2224 572-574 CD denotes 32
T2225 574-575 -RRB- denotes ]
T2226 575-577 , denotes ,
T2201 577-583 VBD denotes showed
T2227 584-591 JJ denotes optimal
T2228 592-603 NN denotes interaction
T2229 604-611 IN denotes between
T2230 612-615 DT denotes the
T2232 616-622 JJ denotes intact
T2233 623-625 NN denotes LD
T2234 626-629 CC denotes and
T2235 630-635 NN denotes Cox11
T2231 636-644 NN denotes proteins
T2236 645-646 -LRB- denotes (
T2238 646-652 NN denotes Figure
T2237 653-655 NN denotes 1C
T2239 655-656 -RRB- denotes )
T2240 656-657 . denotes .
T2241 657-869 sentence denotes Pull-down assays of retinal extracts with glutathione S-transferase (GST)-LD precipitates a sodium dodecyl sulfate-resistant dimer isoform of Cox11 (Figure 1D, top panel), which does not bind to GST-LDZIP alone.
T2242 658-662 VB denotes Pull
T2244 662-663 HYPH denotes -
T2245 663-667 RP denotes down
T2243 668-674 NNS denotes assays
T2247 675-677 IN denotes of
T2248 678-685 JJ denotes retinal
T2249 686-694 NNS denotes extracts
T2250 695-699 IN denotes with
T2251 700-711 NN denotes glutathione
T2253 712-713 NN denotes S
T2254 713-714 HYPH denotes -
T2252 714-725 NN denotes transferase
T2256 726-727 -LRB- denotes (
T2257 727-730 NN denotes GST
T2258 730-731 -RRB- denotes )
T2259 731-732 HYPH denotes -
T2255 732-734 NN denotes LD
T2246 735-747 VBZ denotes precipitates
T2260 748-749 DT denotes a
T2262 750-756 NN denotes sodium
T2264 757-764 NN denotes dodecyl
T2263 765-772 NN denotes sulfate
T2266 772-773 HYPH denotes -
T2265 773-782 JJ denotes resistant
T2267 783-788 NN denotes dimer
T2261 789-796 NN denotes isoform
T2268 797-799 IN denotes of
T2269 800-805 NN denotes Cox11
T2270 806-807 -LRB- denotes (
T2272 807-813 NN denotes Figure
T2273 814-816 NN denotes 1D
T2274 816-818 , denotes ,
T2275 818-821 JJ denotes top
T2271 822-827 NN denotes panel
T2276 827-828 -RRB- denotes )
T2277 828-830 , denotes ,
T2278 830-835 WDT denotes which
T2280 836-840 VBZ denotes does
T2281 841-844 RB denotes not
T2279 845-849 VB denotes bind
T2282 850-852 IN denotes to
T2283 853-856 NN denotes GST
T2285 856-857 HYPH denotes -
T2284 857-862 NN denotes LDZIP
T2286 863-868 RB denotes alone
T2287 868-869 . denotes .
T2288 869-1084 sentence denotes In addition to Cox11, we also found that other mitochondrial components such as the outer membrane-associated protein, HKI [33] (Figure 1D, bottom panel) and mHsp70 (unpublished data), associated with LD of RanBP2.
T2289 870-872 IN denotes In
T2291 873-881 NN denotes addition
T2292 882-884 IN denotes to
T2293 885-890 NN denotes Cox11
T2294 890-892 , denotes ,
T2295 892-894 PRP denotes we
T2296 895-899 RB denotes also
T2290 900-905 VBD denotes found
T2297 906-910 IN denotes that
T2299 911-916 JJ denotes other
T2301 917-930 JJ denotes mitochondrial
T2300 931-941 NNS denotes components
T2302 942-946 JJ denotes such
T2303 947-949 IN denotes as
T2304 950-953 DT denotes the
T2306 954-959 JJ denotes outer
T2307 960-968 NN denotes membrane
T2309 968-969 HYPH denotes -
T2308 969-979 VBN denotes associated
T2305 980-987 NN denotes protein
T2310 987-989 , denotes ,
T2311 989-992 NN denotes HKI
T2312 993-994 -LRB- denotes [
T2313 994-996 CD denotes 33
T2314 996-997 -RRB- denotes ]
T2315 998-999 -LRB- denotes (
T2317 999-1005 NN denotes Figure
T2318 1006-1008 NN denotes 1D
T2319 1008-1010 , denotes ,
T2320 1010-1016 JJ denotes bottom
T2316 1017-1022 NN denotes panel
T2321 1022-1023 -RRB- denotes )
T2322 1024-1027 CC denotes and
T2323 1028-1034 NN denotes mHsp70
T2324 1035-1036 -LRB- denotes (
T2326 1036-1047 JJ denotes unpublished
T2325 1048-1052 NNS denotes data
T2327 1052-1053 -RRB- denotes )
T2328 1053-1055 , denotes ,
T2298 1055-1065 VBD denotes associated
T2329 1066-1070 IN denotes with
T2330 1071-1073 NN denotes LD
T2331 1074-1076 IN denotes of
T2332 1077-1083 NN denotes RanBP2
T2333 1083-1084 . denotes .
T2334 1084-1241 sentence denotes This association was highly specific toward the HKI isoform, because HKII, HKIII, and glucokinase did not interact with the LD of RanBP2 (unpublished data).
T2335 1085-1089 DT denotes This
T2336 1090-1101 NN denotes association
T2337 1102-1105 VBD denotes was
T2338 1106-1112 RB denotes highly
T2339 1113-1121 JJ denotes specific
T2340 1122-1128 IN denotes toward
T2341 1129-1132 DT denotes the
T2343 1133-1136 NN denotes HKI
T2342 1137-1144 NN denotes isoform
T2344 1144-1146 , denotes ,
T2345 1146-1153 IN denotes because
T2347 1154-1158 NN denotes HKII
T2348 1158-1160 , denotes ,
T2349 1160-1165 NN denotes HKIII
T2350 1165-1167 , denotes ,
T2351 1167-1170 CC denotes and
T2352 1171-1182 NN denotes glucokinase
T2353 1183-1186 VBD denotes did
T2354 1187-1190 RB denotes not
T2346 1191-1199 VB denotes interact
T2355 1200-1204 IN denotes with
T2356 1205-1208 DT denotes the
T2357 1209-1211 NN denotes LD
T2358 1212-1214 IN denotes of
T2359 1215-1221 NN denotes RanBP2
T2360 1222-1223 -LRB- denotes (
T2362 1223-1234 JJ denotes unpublished
T2361 1235-1239 NNS denotes data
T2363 1239-1240 -RRB- denotes )
T2364 1240-1241 . denotes .
T2365 1241-1525 sentence denotes The interaction of Cox11, HKI, and mHsp70 with RanBP2 occurred in vivo in retinal extracts, since antibodies against these and RanBP2 coimmunoprecipitated RanBP2 (Figure 1E) and HKI (Figure 1F), respectively, and these interactions were observed across different tissues (Figure S1).
T2366 1242-1245 DT denotes The
T2367 1246-1257 NN denotes interaction
T2369 1258-1260 IN denotes of
T2370 1261-1266 NN denotes Cox11
T2371 1266-1268 , denotes ,
T2372 1268-1271 NN denotes HKI
T2373 1271-1273 , denotes ,
T2374 1273-1276 CC denotes and
T2375 1277-1283 NN denotes mHsp70
T2376 1284-1288 IN denotes with
T2377 1289-1295 NN denotes RanBP2
T2368 1296-1304 VBD denotes occurred
T2378 1305-1307 FW denotes in
T2379 1308-1312 FW denotes vivo
T2380 1313-1315 IN denotes in
T2381 1316-1323 JJ denotes retinal
T2382 1324-1332 NNS denotes extracts
T2383 1332-1334 , denotes ,
T2384 1334-1339 IN denotes since
T2386 1340-1350 NNS denotes antibodies
T2387 1351-1358 IN denotes against
T2388 1359-1364 DT denotes these
T2390 1365-1368 CC denotes and
T2389 1369-1375 NN denotes RanBP2
T2385 1376-1396 VBD denotes coimmunoprecipitated
T2391 1397-1403 NN denotes RanBP2
T2392 1404-1405 -LRB- denotes (
T2394 1405-1411 NN denotes Figure
T2393 1412-1414 NN denotes 1E
T2395 1414-1415 -RRB- denotes )
T2396 1416-1419 CC denotes and
T2397 1420-1423 NN denotes HKI
T2398 1424-1425 -LRB- denotes (
T2400 1425-1431 NN denotes Figure
T2399 1432-1434 NN denotes 1F
T2401 1434-1435 -RRB- denotes )
T2402 1435-1437 , denotes ,
T2403 1437-1449 RB denotes respectively
T2404 1449-1451 , denotes ,
T2405 1451-1454 CC denotes and
T2406 1455-1460 DT denotes these
T2407 1461-1473 NNS denotes interactions
T2409 1474-1478 VBD denotes were
T2408 1479-1487 VBN denotes observed
T2410 1488-1494 IN denotes across
T2411 1495-1504 JJ denotes different
T2412 1505-1512 NNS denotes tissues
T2413 1513-1514 -LRB- denotes (
T2415 1514-1520 NN denotes Figure
T2414 1521-1523 NN denotes S1
T2416 1523-1524 -RRB- denotes )
T2417 1524-1525 . denotes .
T2418 1525-1715 sentence denotes Since RanBP2 exhibits chaperone activity, we assessed whether the interaction between the LD of RanBP2 and Cox11 was direct and the chaperone activity of LD toward folding species of Cox11.
T2419 1526-1531 IN denotes Since
T2421 1532-1538 NN denotes RanBP2
T2420 1539-1547 VBZ denotes exhibits
T2423 1548-1557 NN denotes chaperone
T2424 1558-1566 NN denotes activity
T2425 1566-1568 , denotes ,
T2426 1568-1570 PRP denotes we
T2422 1571-1579 VBD denotes assessed
T2427 1580-1587 IN denotes whether
T2429 1588-1591 DT denotes the
T2430 1592-1603 NN denotes interaction
T2431 1604-1611 IN denotes between
T2432 1612-1615 DT denotes the
T2433 1616-1618 NN denotes LD
T2434 1619-1621 IN denotes of
T2435 1622-1628 NN denotes RanBP2
T2436 1629-1632 CC denotes and
T2437 1633-1638 NN denotes Cox11
T2428 1639-1642 VBD denotes was
T2438 1643-1649 JJ denotes direct
T2439 1650-1653 CC denotes and
T2441 1654-1657 DT denotes the
T2442 1658-1667 NN denotes chaperone
T2440 1668-1676 NN denotes activity
T2443 1677-1679 IN denotes of
T2444 1680-1682 NN denotes LD
T2445 1683-1689 IN denotes toward
T2446 1690-1697 VBG denotes folding
T2447 1698-1705 NNS denotes species
T2448 1706-1708 IN denotes of
T2449 1709-1714 NN denotes Cox11
T2450 1714-1715 . denotes .
T2451 1715-1895 sentence denotes Reconstitution binding assays were carried out between purified LD and Cox11, fully and partially denatured with GnHCl and urea, respectively, and native Cox11 (Figure 1G and 1H).
T2452 1716-1730 NN denotes Reconstitution
T2453 1731-1738 NN denotes binding
T2454 1739-1745 NNS denotes assays
T2456 1746-1750 VBD denotes were
T2455 1751-1758 VBN denotes carried
T2457 1759-1762 RP denotes out
T2458 1763-1770 IN denotes between
T2459 1771-1779 VBN denotes purified
T2460 1780-1782 NN denotes LD
T2461 1783-1786 CC denotes and
T2462 1787-1792 NN denotes Cox11
T2463 1792-1794 , denotes ,
T2464 1794-1799 RB denotes fully
T2466 1800-1803 CC denotes and
T2467 1804-1813 RB denotes partially
T2465 1814-1823 VBN denotes denatured
T2468 1824-1828 IN denotes with
T2469 1829-1834 NN denotes GnHCl
T2470 1835-1838 CC denotes and
T2471 1839-1843 NN denotes urea
T2472 1843-1845 , denotes ,
T2473 1845-1857 RB denotes respectively
T2474 1857-1859 , denotes ,
T2475 1859-1862 CC denotes and
T2476 1863-1869 JJ denotes native
T2477 1870-1875 NN denotes Cox11
T2478 1876-1877 -LRB- denotes (
T2480 1877-1883 NN denotes Figure
T2479 1884-1886 NN denotes 1G
T2481 1887-1890 CC denotes and
T2482 1891-1893 NN denotes 1H
T2483 1893-1894 -RRB- denotes )
T2484 1894-1895 . denotes .
T2485 1895-2068 sentence denotes Partial denatured Cox11 exhibits significantly higher and concentration-dependent binding affinity toward LD compared with the native and fully denatured Cox11 (Figure 1G).
T2486 1896-1903 JJ denotes Partial
T2487 1904-1913 VBN denotes denatured
T2488 1914-1919 NN denotes Cox11
T2489 1920-1928 VBZ denotes exhibits
T2490 1929-1942 RB denotes significantly
T2491 1943-1949 JJR denotes higher
T2493 1950-1953 CC denotes and
T2494 1954-1967 NN denotes concentration
T2496 1967-1968 HYPH denotes -
T2495 1968-1977 JJ denotes dependent
T2497 1978-1985 NN denotes binding
T2492 1986-1994 NN denotes affinity
T2498 1995-2001 IN denotes toward
T2499 2002-2004 NN denotes LD
T2500 2005-2013 VBN denotes compared
T2501 2014-2018 IN denotes with
T2502 2019-2022 DT denotes the
T2504 2023-2029 JJ denotes native
T2505 2030-2033 CC denotes and
T2506 2034-2039 RB denotes fully
T2507 2040-2049 VBN denotes denatured
T2503 2050-2055 NN denotes Cox11
T2508 2056-2057 -LRB- denotes (
T2510 2057-2063 NN denotes Figure
T2509 2064-2066 NN denotes 1G
T2511 2066-2067 -RRB- denotes )
T2512 2067-2068 . denotes .
T2513 2068-2305 sentence denotes In addition, native Cox11 purified upon expression in the presence of CuSO4 (a prosthetic group tightly bound to Cox11) [31], shows significantly higher binding activity toward the LD of RanBP2, than in the absence of CuSO4 (Figure 1H).
T2514 2069-2071 IN denotes In
T2516 2072-2080 NN denotes addition
T2517 2080-2082 , denotes ,
T2518 2082-2088 JJ denotes native
T2519 2089-2094 NN denotes Cox11
T2520 2095-2103 VBN denotes purified
T2521 2104-2108 IN denotes upon
T2522 2109-2119 NN denotes expression
T2523 2120-2122 IN denotes in
T2524 2123-2126 DT denotes the
T2525 2127-2135 NN denotes presence
T2526 2136-2138 IN denotes of
T2527 2139-2144 NN denotes CuSO4
T2528 2145-2146 -LRB- denotes (
T2529 2146-2147 DT denotes a
T2531 2148-2158 JJ denotes prosthetic
T2530 2159-2164 NN denotes group
T2532 2165-2172 RB denotes tightly
T2533 2173-2178 VBN denotes bound
T2534 2179-2181 IN denotes to
T2535 2182-2187 NN denotes Cox11
T2536 2187-2188 -RRB- denotes )
T2537 2189-2190 -LRB- denotes [
T2538 2190-2192 CD denotes 31
T2539 2192-2193 -RRB- denotes ]
T2540 2193-2195 , denotes ,
T2515 2195-2200 VBZ denotes shows
T2541 2201-2214 RB denotes significantly
T2542 2215-2221 JJR denotes higher
T2544 2222-2229 NN denotes binding
T2543 2230-2238 NN denotes activity
T2545 2239-2245 IN denotes toward
T2546 2246-2249 DT denotes the
T2547 2250-2252 NN denotes LD
T2548 2253-2255 IN denotes of
T2549 2256-2262 NN denotes RanBP2
T2550 2262-2264 , denotes ,
T2551 2264-2268 IN denotes than
T2552 2269-2271 IN denotes in
T2553 2272-2275 DT denotes the
T2554 2276-2283 NN denotes absence
T2555 2284-2286 IN denotes of
T2556 2287-2292 NN denotes CuSO4
T2557 2293-2294 -LRB- denotes (
T2559 2294-2300 NN denotes Figure
T2558 2301-2303 NN denotes 1H
T2560 2303-2304 -RRB- denotes )
T2561 2304-2305 . denotes .
T10852 2316-2319 DT denotes The
T10853 2320-2322 NN denotes LD
T10855 2323-2325 IN denotes of
T10856 2326-2332 NN denotes RanBP2
T10854 2333-2342 VBZ denotes Interacts
T10857 2343-2347 IN denotes with
T10858 2348-2353 NN denotes Cox11
T10859 2354-2357 CC denotes and
T10860 2358-2361 NN denotes HKI
T10861 2361-2432 sentence denotes (A) Primary structure of RanBP2 and its structural/functional domains.
T10862 2362-2363 -LRB- denotes (
T10863 2363-2364 LS denotes A
T10865 2364-2365 -RRB- denotes )
T10866 2366-2373 JJ denotes Primary
T10864 2374-2383 NN denotes structure
T10867 2384-2386 IN denotes of
T10868 2387-2393 NN denotes RanBP2
T10869 2394-2397 CC denotes and
T10870 2398-2401 PRP$ denotes its
T10872 2402-2412 JJ denotes structural
T10874 2412-2413 HYPH denotes /
T10873 2413-2423 JJ denotes functional
T10871 2424-2431 NNS denotes domains
T10875 2431-2432 . denotes .
T10876 2432-2475 sentence denotes The N-terminal LD of RanBP2 is underlined.
T10877 2433-2436 DT denotes The
T10879 2437-2438 NN denotes N
T10881 2438-2439 HYPH denotes -
T10880 2439-2447 JJ denotes terminal
T10878 2448-2450 NN denotes LD
T10883 2451-2453 IN denotes of
T10884 2454-2460 NN denotes RanBP2
T10885 2461-2463 VBZ denotes is
T10882 2464-2474 VBN denotes underlined
T10886 2474-2475 . denotes .
T10887 2475-2525 sentence denotes (B) Sequence alignment of murine and yeast Cox11.
T10888 2476-2477 -LRB- denotes (
T10889 2477-2478 LS denotes B
T10891 2478-2479 -RRB- denotes )
T10892 2480-2488 NN denotes Sequence
T10890 2489-2498 NN denotes alignment
T10893 2499-2501 IN denotes of
T10894 2502-2508 JJ denotes murine
T10896 2509-2512 CC denotes and
T10897 2513-2518 NN denotes yeast
T10895 2519-2524 NN denotes Cox11
T10898 2524-2525 . denotes .
T10899 2525-2589 sentence denotes The yeast Cox11 C- and N-terminal domains are poorly conserved.
T10900 2526-2529 DT denotes The
T10902 2530-2535 NN denotes yeast
T10903 2536-2541 NN denotes Cox11
T10904 2542-2543 NN denotes C
T10906 2543-2544 HYPH denotes -
T10907 2545-2548 CC denotes and
T10908 2549-2550 NN denotes N
T10909 2550-2551 HYPH denotes -
T10905 2551-2559 JJ denotes terminal
T10901 2560-2567 NNS denotes domains
T10911 2568-2571 VBP denotes are
T10912 2572-2578 RB denotes poorly
T10910 2579-2588 VBN denotes conserved
T10913 2588-2589 . denotes .
T10914 2589-2689 sentence denotes Arrow and solid line denote the predicted mitochondrial cleavage site and membrane-spanning domain.
T10915 2590-2595 NN denotes Arrow
T10917 2596-2599 CC denotes and
T10918 2600-2605 JJ denotes solid
T10919 2606-2610 NN denotes line
T10916 2611-2617 VBP denotes denote
T10920 2618-2621 DT denotes the
T10922 2622-2631 VBN denotes predicted
T10923 2632-2645 JJ denotes mitochondrial
T10924 2646-2654 NN denotes cleavage
T10921 2655-2659 NN denotes site
T10925 2660-2663 CC denotes and
T10926 2664-2672 NN denotes membrane
T10928 2672-2673 HYPH denotes -
T10927 2673-2681 VBG denotes spanning
T10929 2682-2688 NN denotes domain
T10930 2688-2689 . denotes .
T10931 2689-2821 sentence denotes The dotted and dashed lines above the aligned sequences represent, respectively, Cox11-N and Cox11-C constructs shown in Figure 1C.
T10932 2690-2693 DT denotes The
T10934 2694-2700 JJ denotes dotted
T10935 2701-2704 CC denotes and
T10936 2705-2711 JJ denotes dashed
T10933 2712-2717 NNS denotes lines
T10938 2718-2723 IN denotes above
T10939 2724-2727 DT denotes the
T10941 2728-2735 JJ denotes aligned
T10940 2736-2745 NNS denotes sequences
T10937 2746-2755 VBP denotes represent
T10942 2755-2757 , denotes ,
T10943 2757-2769 RB denotes respectively
T10944 2769-2771 , denotes ,
T10945 2771-2776 NN denotes Cox11
T10947 2776-2777 HYPH denotes -
T10946 2777-2778 NN denotes N
T10949 2779-2782 CC denotes and
T10950 2783-2788 NN denotes Cox11
T10952 2788-2789 HYPH denotes -
T10951 2789-2790 NN denotes C
T10948 2791-2801 NNS denotes constructs
T10953 2802-2807 VBN denotes shown
T10954 2808-2810 IN denotes in
T10955 2811-2817 NN denotes Figure
T10956 2818-2820 NN denotes 1C
T10957 2820-2821 . denotes .
T10958 2821-2908 sentence denotes (C) Structure-function analysis of the interaction between the LD of RanBP2 and Cox11.
T10959 2822-2823 -LRB- denotes (
T10960 2823-2824 LS denotes C
T10962 2824-2825 -RRB- denotes )
T10963 2826-2835 NN denotes Structure
T10965 2835-2836 HYPH denotes -
T10964 2836-2844 NN denotes function
T10961 2845-2853 NN denotes analysis
T10966 2854-2856 IN denotes of
T10967 2857-2860 DT denotes the
T10968 2861-2872 NN denotes interaction
T10969 2873-2880 IN denotes between
T10970 2881-2884 DT denotes the
T10971 2885-2887 NN denotes LD
T10972 2888-2890 IN denotes of
T10973 2891-2897 NN denotes RanBP2
T10974 2898-2901 CC denotes and
T10975 2902-2907 NN denotes Cox11
T10976 2907-2908 . denotes .
T10977 2908-3035 sentence denotes Optimal interaction between the LD and Cox11 occurred in the presence of constructs comprising both the complete LD and Cox11.
T10978 2909-2916 JJ denotes Optimal
T10979 2917-2928 NN denotes interaction
T10981 2929-2936 IN denotes between
T10982 2937-2940 DT denotes the
T10983 2941-2943 NN denotes LD
T10984 2944-2947 CC denotes and
T10985 2948-2953 NN denotes Cox11
T10980 2954-2962 VBD denotes occurred
T10986 2963-2965 IN denotes in
T10987 2966-2969 DT denotes the
T10988 2970-2978 NN denotes presence
T10989 2979-2981 IN denotes of
T10990 2982-2992 NNS denotes constructs
T10991 2993-3003 VBG denotes comprising
T10992 3004-3008 CC denotes both
T10994 3009-3012 DT denotes the
T10995 3013-3021 JJ denotes complete
T10993 3022-3024 NN denotes LD
T10996 3025-3028 CC denotes and
T10997 3029-3034 NN denotes Cox11
T10998 3034-3035 . denotes .
T10999 3035-3287 sentence denotes Although removal of the cytosolic N-terminal (Cox11-C) significantly decreased the interaction with LD, the mitochondrial intermembrane domain of Cox11 (Cox11-C) together with the C-terminal half of LD (LD-C) retained most of the interaction activity.
T11000 3036-3044 IN denotes Although
T11002 3045-3052 NN denotes removal
T11003 3053-3055 IN denotes of
T11004 3056-3059 DT denotes the
T11006 3060-3069 JJ denotes cytosolic
T11005 3070-3071 NN denotes N
T11007 3071-3072 HYPH denotes -
T11008 3072-3080 JJ denotes terminal
T11009 3081-3082 -LRB- denotes (
T11010 3082-3087 NN denotes Cox11
T11012 3087-3088 HYPH denotes -
T11011 3088-3089 NN denotes C
T11013 3089-3090 -RRB- denotes )
T11014 3091-3104 RB denotes significantly
T11001 3105-3114 VBD denotes decreased
T11016 3115-3118 DT denotes the
T11017 3119-3130 NN denotes interaction
T11018 3131-3135 IN denotes with
T11019 3136-3138 NN denotes LD
T11020 3138-3140 , denotes ,
T11021 3140-3143 DT denotes the
T11023 3144-3157 JJ denotes mitochondrial
T11024 3158-3171 NN denotes intermembrane
T11022 3172-3178 NN denotes domain
T11025 3179-3181 IN denotes of
T11026 3182-3187 NN denotes Cox11
T11027 3188-3189 -LRB- denotes (
T11028 3189-3194 NN denotes Cox11
T11030 3194-3195 HYPH denotes -
T11029 3195-3196 NN denotes C
T11031 3196-3197 -RRB- denotes )
T11032 3198-3206 RB denotes together
T11033 3207-3211 IN denotes with
T11034 3212-3215 DT denotes the
T11036 3216-3217 NN denotes C
T11038 3217-3218 HYPH denotes -
T11037 3218-3226 JJ denotes terminal
T11035 3227-3231 NN denotes half
T11039 3232-3234 IN denotes of
T11040 3235-3237 NN denotes LD
T11041 3238-3239 -LRB- denotes (
T11042 3239-3241 NN denotes LD
T11044 3241-3242 HYPH denotes -
T11043 3242-3243 NN denotes C
T11045 3243-3244 -RRB- denotes )
T11015 3245-3253 VBD denotes retained
T11046 3254-3258 JJS denotes most
T11047 3259-3261 IN denotes of
T11048 3262-3265 DT denotes the
T11050 3266-3277 NN denotes interaction
T11049 3278-3286 NN denotes activity
T11051 3286-3287 . denotes .
T11052 3287-3359 sentence denotes LD-N and LD-C ended and began with the leucine zipper domain of RanBP2.
T11053 3288-3290 NN denotes LD
T11055 3290-3291 HYPH denotes -
T11054 3291-3292 NN denotes N
T11057 3293-3296 CC denotes and
T11058 3297-3299 NN denotes LD
T11060 3299-3300 HYPH denotes -
T11059 3300-3301 NN denotes C
T11056 3302-3307 VBD denotes ended
T11061 3308-3311 CC denotes and
T11062 3312-3317 VBD denotes began
T11063 3318-3322 IN denotes with
T11064 3323-3326 DT denotes the
T11066 3327-3334 NN denotes leucine
T11067 3335-3341 NN denotes zipper
T11065 3342-3348 NN denotes domain
T11068 3349-3351 IN denotes of
T11069 3352-3358 NN denotes RanBP2
T11070 3358-3359 . denotes .
T11071 3359-3471 sentence denotes White and black bars denote β-galactosidase activity and growth rates in selective growth medium, respectively.
T11072 3360-3365 JJ denotes White
T11074 3366-3369 CC denotes and
T11075 3370-3375 JJ denotes black
T11073 3376-3380 NNS denotes bars
T11076 3381-3387 VBP denotes denote
T11077 3388-3389 NN denotes β
T11079 3389-3390 HYPH denotes -
T11078 3390-3403 NN denotes galactosidase
T11080 3404-3412 NN denotes activity
T11081 3413-3416 CC denotes and
T11082 3417-3423 NN denotes growth
T11083 3424-3429 NNS denotes rates
T11084 3430-3432 IN denotes in
T11085 3433-3442 JJ denotes selective
T11087 3443-3449 NN denotes growth
T11086 3450-3456 NN denotes medium
T11088 3456-3458 , denotes ,
T11089 3458-3470 RB denotes respectively
T11090 3470-3471 . denotes .
T11091 3471-3517 sentence denotes Results shown represent the mean ± SD, n = 3.
T11092 3472-3479 NNS denotes Results
T11094 3480-3485 VBN denotes shown
T11093 3486-3495 VBP denotes represent
T11096 3496-3499 DT denotes the
T11098 3500-3504 NN denotes mean
T11099 3505-3506 SYM denotes ±
T11097 3507-3509 NN denotes SD
T11100 3509-3511 , denotes ,
T11101 3511-3512 NN denotes n
T11102 3513-3514 SYM denotes =
T11095 3515-3516 CD denotes 3
T11103 3516-3517 . denotes .
T11104 3517-3616 sentence denotes (D) GST pull-down assays with the LD of RanBP2 and its leucine zipper domain and retinal extracts.
T11105 3518-3519 -LRB- denotes (
T11106 3519-3520 LS denotes D
T11108 3520-3521 -RRB- denotes )
T11109 3522-3525 NN denotes GST
T11110 3526-3530 VB denotes pull
T11111 3530-3531 HYPH denotes -
T11112 3531-3535 RP denotes down
T11107 3536-3542 NNS denotes assays
T11113 3543-3547 IN denotes with
T11114 3548-3551 DT denotes the
T11115 3552-3554 NN denotes LD
T11116 3555-3557 IN denotes of
T11117 3558-3564 NN denotes RanBP2
T11118 3565-3568 CC denotes and
T11119 3569-3572 PRP$ denotes its
T11121 3573-3580 NN denotes leucine
T11122 3581-3587 NN denotes zipper
T11120 3588-3594 NN denotes domain
T11123 3595-3598 CC denotes and
T11124 3599-3606 JJ denotes retinal
T11125 3607-3615 NNS denotes extracts
T11126 3615-3616 . denotes .
T11127 3616-3742 sentence denotes The LD, but not the leucine zipper domain of RanBP2, associate with Cox11 (top panel, lane 1) and HKI (bottom panel, lane 1).
T11128 3617-3620 DT denotes The
T11129 3621-3623 NN denotes LD
T11131 3623-3625 , denotes ,
T11132 3625-3628 CC denotes but
T11133 3629-3632 RB denotes not
T11134 3633-3636 DT denotes the
T11136 3637-3644 NN denotes leucine
T11137 3645-3651 NN denotes zipper
T11135 3652-3658 NN denotes domain
T11138 3659-3661 IN denotes of
T11139 3662-3668 NN denotes RanBP2
T11140 3668-3670 , denotes ,
T11130 3670-3679 VBP denotes associate
T11141 3680-3684 IN denotes with
T11142 3685-3690 NN denotes Cox11
T11143 3691-3692 -LRB- denotes (
T11145 3692-3695 JJ denotes top
T11146 3696-3701 NN denotes panel
T11147 3701-3703 , denotes ,
T11144 3703-3707 NN denotes lane
T11148 3708-3709 CD denotes 1
T11149 3709-3710 -RRB- denotes )
T11150 3711-3714 CC denotes and
T11151 3715-3718 NN denotes HKI
T11152 3719-3720 -LRB- denotes (
T11154 3720-3726 JJ denotes bottom
T11155 3727-3732 NN denotes panel
T11156 3732-3734 , denotes ,
T11153 3734-3738 NN denotes lane
T11157 3739-3740 CD denotes 1
T11158 3740-3741 -RRB- denotes )
T11159 3741-3742 . denotes .
T11160 3742-3930 sentence denotes (E) Coimmunoprecipitation of RanBP2 with antibodies against its molecular partners shows that RanBP2 forms a complex in vivo with HKI (lanes 1 and 2), mHsp70 (lane 3), and Cox11 (lane 4).
T11161 3743-3744 -LRB- denotes (
T11162 3744-3745 LS denotes E
T11164 3745-3746 -RRB- denotes )
T11165 3747-3768 NN denotes Coimmunoprecipitation
T11166 3769-3771 IN denotes of
T11167 3772-3778 NN denotes RanBP2
T11168 3779-3783 IN denotes with
T11169 3784-3794 NNS denotes antibodies
T11170 3795-3802 IN denotes against
T11171 3803-3806 PRP$ denotes its
T11173 3807-3816 JJ denotes molecular
T11172 3817-3825 NNS denotes partners
T11163 3826-3831 VBZ denotes shows
T11174 3832-3836 IN denotes that
T11176 3837-3843 NN denotes RanBP2
T11175 3844-3849 VBZ denotes forms
T11177 3850-3851 DT denotes a
T11178 3852-3859 JJ denotes complex
T11179 3860-3862 FW denotes in
T11180 3863-3867 FW denotes vivo
T11181 3868-3872 IN denotes with
T11182 3873-3876 NN denotes HKI
T11183 3877-3878 -LRB- denotes (
T11185 3878-3883 NNS denotes lanes
T11184 3884-3885 CD denotes 1
T11186 3886-3889 CC denotes and
T11187 3890-3891 CD denotes 2
T11188 3891-3892 -RRB- denotes )
T11189 3892-3894 , denotes ,
T11190 3894-3900 NN denotes mHsp70
T11191 3901-3902 -LRB- denotes (
T11192 3902-3906 NN denotes lane
T11193 3907-3908 CD denotes 3
T11194 3908-3909 -RRB- denotes )
T11195 3909-3911 , denotes ,
T11196 3911-3914 CC denotes and
T11197 3915-3920 NN denotes Cox11
T11198 3921-3922 -LRB- denotes (
T11199 3922-3926 NN denotes lane
T11200 3927-3928 CD denotes 4
T11201 3928-3929 -RRB- denotes )
T11202 3929-3930 . denotes .
T11203 3930-4082 sentence denotes Lanes 5, 6, and 7 are control immunoprecipitation reactions with different antibodies against the RanBP2 domains, KBD, ZnF, and XAFXFG of nucleoporins.
T11204 3931-3936 NNS denotes Lanes
T11205 3937-3938 CD denotes 5
T11207 3938-3940 , denotes ,
T11208 3940-3941 CD denotes 6
T11209 3941-3943 , denotes ,
T11210 3943-3946 CC denotes and
T11211 3947-3948 CD denotes 7
T11206 3949-3952 VBP denotes are
T11212 3953-3960 NN denotes control
T11214 3961-3980 NN denotes immunoprecipitation
T11213 3981-3990 NNS denotes reactions
T11215 3991-3995 IN denotes with
T11216 3996-4005 JJ denotes different
T11217 4006-4016 NNS denotes antibodies
T11218 4017-4024 IN denotes against
T11219 4025-4028 DT denotes the
T11221 4029-4035 NN denotes RanBP2
T11220 4036-4043 NNS denotes domains
T11222 4043-4045 , denotes ,
T11223 4045-4048 NN denotes KBD
T11224 4048-4050 , denotes ,
T11225 4050-4053 NN denotes ZnF
T11226 4053-4055 , denotes ,
T11227 4055-4058 CC denotes and
T11228 4059-4065 NN denotes XAFXFG
T11229 4066-4068 IN denotes of
T11230 4069-4081 NNS denotes nucleoporins
T11231 4081-4082 . denotes .
T11232 4082-4182 sentence denotes (F) Reciprocal coimmunoprecipitation of HKI with antibodies against RanBP2 (used and shown in (E)).
T11233 4083-4084 -LRB- denotes (
T11234 4084-4085 LS denotes F
T11236 4085-4086 -RRB- denotes )
T11237 4087-4097 JJ denotes Reciprocal
T11235 4098-4119 NN denotes coimmunoprecipitation
T11238 4120-4122 IN denotes of
T11239 4123-4126 NN denotes HKI
T11240 4127-4131 IN denotes with
T11241 4132-4142 NNS denotes antibodies
T11242 4143-4150 IN denotes against
T11243 4151-4157 NN denotes RanBP2
T11244 4158-4159 -LRB- denotes (
T11245 4159-4163 VBN denotes used
T11246 4164-4167 CC denotes and
T11247 4168-4173 VBN denotes shown
T11248 4174-4176 IN denotes in
T11249 4177-4178 -LRB- denotes (
T11250 4178-4179 NN denotes E
T11251 4179-4180 -RRB- denotes )
T11252 4180-4181 -RRB- denotes )
T11253 4181-4182 . denotes .
T11254 4182-4459 sentence denotes (G) Reconstitution pull-down assays with purified LD and increasing concentrations of native (top panel), denatured (middle panel), and partially denatured (bottom panel) Cox11, respectively, in the absence and presence of denaturating agent, GnHCl and chaotropic agent, urea.
T11255 4183-4184 -LRB- denotes (
T11256 4184-4185 LS denotes G
T11258 4185-4186 -RRB- denotes )
T11259 4187-4201 NN denotes Reconstitution
T11260 4202-4206 VB denotes pull
T11261 4206-4207 HYPH denotes -
T11262 4207-4211 RP denotes down
T11257 4212-4218 NNS denotes assays
T11263 4219-4223 IN denotes with
T11264 4224-4232 VBN denotes purified
T11265 4233-4235 NN denotes LD
T11266 4236-4239 CC denotes and
T11267 4240-4250 VBG denotes increasing
T11268 4251-4265 NNS denotes concentrations
T11269 4266-4268 IN denotes of
T11270 4269-4275 JJ denotes native
T11272 4276-4277 -LRB- denotes (
T11274 4277-4280 JJ denotes top
T11273 4281-4286 NN denotes panel
T11275 4286-4287 -RRB- denotes )
T11276 4287-4289 , denotes ,
T11277 4289-4298 VBN denotes denatured
T11278 4299-4300 -LRB- denotes (
T11280 4300-4306 JJ denotes middle
T11279 4307-4312 NN denotes panel
T11281 4312-4313 -RRB- denotes )
T11282 4313-4315 , denotes ,
T11283 4315-4318 CC denotes and
T11284 4319-4328 RB denotes partially
T11285 4329-4338 VBN denotes denatured
T11286 4339-4340 -LRB- denotes (
T11288 4340-4346 JJ denotes bottom
T11287 4347-4352 NN denotes panel
T11289 4352-4353 -RRB- denotes )
T11271 4354-4359 NN denotes Cox11
T11290 4359-4361 , denotes ,
T11291 4361-4373 RB denotes respectively
T11292 4373-4375 , denotes ,
T11293 4375-4377 IN denotes in
T11294 4378-4381 DT denotes the
T11295 4382-4389 NN denotes absence
T11296 4390-4393 CC denotes and
T11297 4394-4402 NN denotes presence
T11298 4403-4405 IN denotes of
T11299 4406-4418 VBG denotes denaturating
T11300 4419-4424 NN denotes agent
T11301 4424-4426 , denotes ,
T11302 4426-4431 NN denotes GnHCl
T11303 4432-4435 CC denotes and
T11304 4436-4446 JJ denotes chaotropic
T11305 4447-4452 NN denotes agent
T11306 4452-4454 , denotes ,
T11307 4454-4458 NN denotes urea
T11308 4458-4459 . denotes .
T11309 4459-4566 sentence denotes Folding intermediates (lower panel) of Cox11 exhibit the highest binding activity toward the LD of RanBP2.
T11310 4460-4467 NN denotes Folding
T11311 4468-4481 NNS denotes intermediates
T11313 4482-4483 -LRB- denotes (
T11315 4483-4488 JJR denotes lower
T11314 4489-4494 NN denotes panel
T11316 4494-4495 -RRB- denotes )
T11317 4496-4498 IN denotes of
T11318 4499-4504 NN denotes Cox11
T11312 4505-4512 VBP denotes exhibit
T11319 4513-4516 DT denotes the
T11321 4517-4524 JJS denotes highest
T11322 4525-4532 NN denotes binding
T11320 4533-4541 NN denotes activity
T11323 4542-4548 IN denotes toward
T11324 4549-4552 DT denotes the
T11325 4553-4555 NN denotes LD
T11326 4556-4558 IN denotes of
T11327 4559-4565 NN denotes RanBP2
T11328 4565-4566 . denotes .
T11329 4566-4710 sentence denotes (H) Similar experiments as in (G) but in the presence of native Cox11 expressed in the absence (top panel) or presence (bottom panel) of CuSO4.
T11330 4567-4568 -LRB- denotes (
T11331 4568-4569 LS denotes H
T11333 4569-4570 -RRB- denotes )
T11334 4571-4578 JJ denotes Similar
T11332 4579-4590 NNS denotes experiments
T11335 4591-4593 IN denotes as
T11336 4594-4596 IN denotes in
T11337 4597-4598 -LRB- denotes (
T11338 4598-4599 NN denotes G
T11339 4599-4600 -RRB- denotes )
T11340 4601-4604 IN denotes but
T11341 4605-4607 IN denotes in
T11342 4608-4611 DT denotes the
T11343 4612-4620 NN denotes presence
T11344 4621-4623 IN denotes of
T11345 4624-4630 JJ denotes native
T11346 4631-4636 NN denotes Cox11
T11347 4637-4646 VBN denotes expressed
T11348 4647-4649 IN denotes in
T11349 4650-4653 DT denotes the
T11350 4654-4661 NN denotes absence
T11351 4662-4663 -LRB- denotes (
T11353 4663-4666 JJ denotes top
T11352 4667-4672 NN denotes panel
T11354 4672-4673 -RRB- denotes )
T11355 4674-4676 CC denotes or
T11356 4677-4685 NN denotes presence
T11357 4686-4687 -LRB- denotes (
T11359 4687-4693 JJ denotes bottom
T11358 4694-4699 NN denotes panel
T11360 4699-4700 -RRB- denotes )
T11361 4701-4703 IN denotes of
T11362 4704-4709 NN denotes CuSO4
T11363 4709-4710 . denotes .
T11364 4710-4804 sentence denotes The mature isoform of the metallochaperone has an increased affinity toward the LD of RanBP2.
T11365 4711-4714 DT denotes The
T11367 4715-4721 JJ denotes mature
T11366 4722-4729 NN denotes isoform
T11369 4730-4732 IN denotes of
T11370 4733-4736 DT denotes the
T11371 4737-4753 NN denotes metallochaperone
T11368 4754-4757 VBZ denotes has
T11372 4758-4760 DT denotes an
T11374 4761-4770 VBN denotes increased
T11373 4771-4779 NN denotes affinity
T11375 4780-4786 IN denotes toward
T11376 4787-4790 DT denotes the
T11377 4791-4793 NN denotes LD
T11378 4794-4796 IN denotes of
T11379 4797-4803 NN denotes RanBP2
T11380 4803-4804 . denotes .
T11381 4804-5047 sentence denotes LD, leucine-rich domain; LZ, leucine zipper domain; RBD1–4, Ran-binding domains 1–4; ZnF, zinc finger cluster domain; KBD, kinesin (KIF5B/KIF5C)-binding domain; CLD, cyclophilin-like domain; IR, internal repeat domain; CY, cyclophilin domain.
T11382 4805-4807 NN denotes LD
T11383 4807-4809 , denotes ,
T11384 4809-4816 NN denotes leucine
T11386 4816-4817 HYPH denotes -
T11385 4817-4821 JJ denotes rich
T11387 4822-4828 NN denotes domain
T11388 4828-4829 : denotes ;
T11389 4830-4832 NN denotes LZ
T11390 4832-4834 , denotes ,
T11391 4834-4841 NN denotes leucine
T11392 4842-4848 NN denotes zipper
T11393 4849-4855 NN denotes domain
T11394 4855-4856 : denotes ;
T11395 4857-4861 NN denotes RBD1
T11396 4861-4862 SYM denotes –
T11397 4862-4863 CD denotes 4
T11398 4863-4865 , denotes ,
T11399 4865-4868 NN denotes Ran
T11401 4868-4869 HYPH denotes -
T11400 4869-4876 NN denotes binding
T11402 4877-4884 NNS denotes domains
T11403 4885-4886 CD denotes 1
T11405 4886-4887 SYM denotes –
T11404 4887-4888 CD denotes 4
T11406 4888-4889 : denotes ;
T11407 4890-4893 NN denotes ZnF
T11408 4893-4895 , denotes ,
T11409 4895-4899 NN denotes zinc
T11410 4900-4906 NN denotes finger
T11412 4907-4914 NN denotes cluster
T11411 4915-4921 NN denotes domain
T11413 4921-4922 : denotes ;
T11414 4923-4926 NN denotes KBD
T11415 4926-4928 , denotes ,
T11416 4928-4935 NN denotes kinesin
T11418 4936-4937 -LRB- denotes (
T11419 4937-4942 NN denotes KIF5B
T11421 4942-4943 HYPH denotes /
T11420 4943-4948 NN denotes KIF5C
T11422 4948-4949 -RRB- denotes )
T11423 4949-4950 HYPH denotes -
T11417 4950-4957 NN denotes binding
T11424 4958-4964 NN denotes domain
T11425 4964-4965 : denotes ;
T11426 4966-4969 NN denotes CLD
T11427 4969-4971 , denotes ,
T11428 4971-4982 NN denotes cyclophilin
T11430 4982-4983 HYPH denotes -
T11429 4983-4987 JJ denotes like
T11431 4988-4994 NN denotes domain
T11432 4994-4995 : denotes ;
T11433 4996-4998 NN denotes IR
T11434 4998-5000 , denotes ,
T11435 5000-5008 JJ denotes internal
T11436 5009-5015 NN denotes repeat
T11437 5016-5022 NN denotes domain
T11438 5022-5023 : denotes ;
T11439 5024-5026 NN denotes CY
T11440 5026-5028 , denotes ,
T11441 5028-5039 NN denotes cyclophilin
T11442 5040-5046 NN denotes domain
T11443 5046-5047 . denotes .
T2637 5049-5052 NN denotes Cox
T2639 5053-5055 CD denotes 11
T2638 5056-5064 VBZ denotes Inhibits
T2640 5065-5068 NN denotes HKI
T2641 5069-5077 NN denotes Activity
T2642 5078-5081 CC denotes and
T2643 5082-5085 DT denotes the
T2644 5086-5088 NN denotes LD
T2645 5089-5091 IN denotes of
T2646 5092-5098 NN denotes RanBP2
T2647 5099-5107 VBZ denotes Reverses
T2648 5108-5111 DT denotes the
T2649 5112-5122 NN denotes Inhibition
T2650 5123-5125 IN denotes of
T2651 5126-5131 NN denotes Cox11
T2652 5132-5136 IN denotes over
T2653 5137-5140 NN denotes HKI
T2654 5140-5380 sentence denotes To probe whether the interaction of Cox11 and HKI with the LD of RanBP2 modulates the enzymatic activity of HKI, we first examined the effect of increasing concentrations of Cox11 on the initial rates of HKI enzymatic activity (Figure 2A).
T2655 5141-5143 TO denotes To
T2656 5144-5149 VB denotes probe
T2658 5150-5157 IN denotes whether
T2660 5158-5161 DT denotes the
T2661 5162-5173 NN denotes interaction
T2662 5174-5176 IN denotes of
T2663 5177-5182 NN denotes Cox11
T2664 5183-5186 CC denotes and
T2665 5187-5190 NN denotes HKI
T2666 5191-5195 IN denotes with
T2667 5196-5199 DT denotes the
T2668 5200-5202 NN denotes LD
T2669 5203-5205 IN denotes of
T2670 5206-5212 NN denotes RanBP2
T2659 5213-5222 VBZ denotes modulates
T2671 5223-5226 DT denotes the
T2673 5227-5236 JJ denotes enzymatic
T2672 5237-5245 NN denotes activity
T2674 5246-5248 IN denotes of
T2675 5249-5252 NN denotes HKI
T2676 5252-5254 , denotes ,
T2677 5254-5256 PRP denotes we
T2678 5257-5262 RB denotes first
T2657 5263-5271 VBD denotes examined
T2679 5272-5275 DT denotes the
T2680 5276-5282 NN denotes effect
T2681 5283-5285 IN denotes of
T2682 5286-5296 VBG denotes increasing
T2683 5297-5311 NNS denotes concentrations
T2684 5312-5314 IN denotes of
T2685 5315-5320 NN denotes Cox11
T2686 5321-5323 IN denotes on
T2687 5324-5327 DT denotes the
T2689 5328-5335 JJ denotes initial
T2688 5336-5341 NNS denotes rates
T2690 5342-5344 IN denotes of
T2691 5345-5348 NN denotes HKI
T2693 5349-5358 JJ denotes enzymatic
T2692 5359-5367 NN denotes activity
T2694 5368-5369 -LRB- denotes (
T2696 5369-5375 NN denotes Figure
T2695 5376-5378 NN denotes 2A
T2697 5378-5379 -RRB- denotes )
T2698 5379-5380 . denotes .
T2699 5380-5527 sentence denotes Cox11 strongly inhibits HKI activity in a concentration-dependent fashion, and at ~15 nM of Cox11, HKI activity could not be recorded (Figure 2A).
T2700 5381-5386 NN denotes Cox11
T2702 5387-5395 RB denotes strongly
T2701 5396-5404 VBZ denotes inhibits
T2703 5405-5408 NN denotes HKI
T2704 5409-5417 NN denotes activity
T2705 5418-5420 IN denotes in
T2706 5421-5422 DT denotes a
T2708 5423-5436 NN denotes concentration
T2710 5436-5437 HYPH denotes -
T2709 5437-5446 JJ denotes dependent
T2707 5447-5454 NN denotes fashion
T2711 5454-5456 , denotes ,
T2712 5456-5459 CC denotes and
T2713 5460-5462 IN denotes at
T2715 5463-5464 SYM denotes ~
T2716 5464-5466 CD denotes 15
T2717 5467-5469 NN denotes nM
T2718 5470-5472 IN denotes of
T2719 5473-5478 NN denotes Cox11
T2720 5478-5480 , denotes ,
T2721 5480-5483 NN denotes HKI
T2722 5484-5492 NN denotes activity
T2723 5493-5498 MD denotes could
T2724 5499-5502 RB denotes not
T2725 5503-5505 VB denotes be
T2714 5506-5514 VBN denotes recorded
T2726 5515-5516 -LRB- denotes (
T2728 5516-5522 NN denotes Figure
T2727 5523-5525 NN denotes 2A
T2729 5525-5526 -RRB- denotes )
T2730 5526-5527 . denotes .
T2731 5527-5641 sentence denotes Cox11 behaves as a partial noncompetitive inhibitor of HKI by affecting the V max of HKI for glucose (Figure 2B).
T2732 5528-5533 NN denotes Cox11
T2733 5534-5541 VBZ denotes behaves
T2734 5542-5544 IN denotes as
T2735 5545-5546 DT denotes a
T2737 5547-5554 JJ denotes partial
T2738 5555-5569 JJ denotes noncompetitive
T2736 5570-5579 NN denotes inhibitor
T2739 5580-5582 IN denotes of
T2740 5583-5586 NN denotes HKI
T2741 5587-5589 IN denotes by
T2742 5590-5599 VBG denotes affecting
T2743 5600-5603 DT denotes the
T2744 5604-5609 NN denotes V max
T2745 5610-5612 IN denotes of
T2746 5613-5616 NN denotes HKI
T2747 5617-5620 IN denotes for
T2748 5621-5628 NN denotes glucose
T2749 5629-5630 -LRB- denotes (
T2751 5630-5636 NN denotes Figure
T2750 5637-5639 NN denotes 2B
T2752 5639-5640 -RRB- denotes )
T2753 5640-5641 . denotes .
T2754 5641-5856 sentence denotes Then, we evaluated the effect of the LD of RanBP2 on the HK activity in the presence of a fixed inhibitory concentration of Cox11, saturating concentration of glucose substrate, and increasing concentrations of LD.
T2755 5642-5646 RB denotes Then
T2757 5646-5648 , denotes ,
T2758 5648-5650 PRP denotes we
T2756 5651-5660 VBD denotes evaluated
T2759 5661-5664 DT denotes the
T2760 5665-5671 NN denotes effect
T2761 5672-5674 IN denotes of
T2762 5675-5678 DT denotes the
T2763 5679-5681 NN denotes LD
T2764 5682-5684 IN denotes of
T2765 5685-5691 NN denotes RanBP2
T2766 5692-5694 IN denotes on
T2767 5695-5698 DT denotes the
T2769 5699-5701 NN denotes HK
T2768 5702-5710 NN denotes activity
T2770 5711-5713 IN denotes in
T2771 5714-5717 DT denotes the
T2772 5718-5726 NN denotes presence
T2773 5727-5729 IN denotes of
T2774 5730-5731 DT denotes a
T2776 5732-5737 VBN denotes fixed
T2777 5738-5748 JJ denotes inhibitory
T2775 5749-5762 NN denotes concentration
T2778 5763-5765 IN denotes of
T2779 5766-5771 NN denotes Cox11
T2780 5771-5773 , denotes ,
T2781 5773-5783 VBG denotes saturating
T2782 5784-5797 NN denotes concentration
T2783 5798-5800 IN denotes of
T2784 5801-5808 NN denotes glucose
T2785 5809-5818 NN denotes substrate
T2786 5818-5820 , denotes ,
T2787 5820-5823 CC denotes and
T2788 5824-5834 VBG denotes increasing
T2789 5835-5849 NNS denotes concentrations
T2790 5850-5852 IN denotes of
T2791 5853-5855 NN denotes LD
T2792 5855-5856 . denotes .
T2793 5856-6230 sentence denotes As shown in Figure 2C, the LD domain sharply reversed the inhibitory effect of Cox11 on HKI activity in a concentration-dependent manner, but under saturating (and stochiometric) amounts of LD, the velocity of the reaction did not reach that observed for HKI activity in the absence of Cox11 (Figure 2A), suggesting the LD by itself may also have an effect on HKI activity.
T2794 5857-5859 IN denotes As
T2795 5860-5865 VBN denotes shown
T2797 5866-5868 IN denotes in
T2798 5869-5875 NN denotes Figure
T2799 5876-5878 NN denotes 2C
T2800 5878-5880 , denotes ,
T2801 5880-5883 DT denotes the
T2803 5884-5886 NN denotes LD
T2802 5887-5893 NN denotes domain
T2804 5894-5901 RB denotes sharply
T2796 5902-5910 VBD denotes reversed
T2805 5911-5914 DT denotes the
T2807 5915-5925 JJ denotes inhibitory
T2806 5926-5932 NN denotes effect
T2808 5933-5935 IN denotes of
T2809 5936-5941 NN denotes Cox11
T2810 5942-5944 IN denotes on
T2811 5945-5948 NN denotes HKI
T2812 5949-5957 NN denotes activity
T2813 5958-5960 IN denotes in
T2814 5961-5962 DT denotes a
T2816 5963-5976 NN denotes concentration
T2818 5976-5977 HYPH denotes -
T2817 5977-5986 JJ denotes dependent
T2815 5987-5993 NN denotes manner
T2819 5993-5995 , denotes ,
T2820 5995-5998 CC denotes but
T2821 5999-6004 IN denotes under
T2823 6005-6015 VBG denotes saturating
T2825 6016-6017 -LRB- denotes (
T2826 6017-6020 CC denotes and
T2827 6021-6034 JJ denotes stochiometric
T2828 6034-6035 -RRB- denotes )
T2824 6036-6043 NNS denotes amounts
T2829 6044-6046 IN denotes of
T2830 6047-6049 NN denotes LD
T2831 6049-6051 , denotes ,
T2832 6051-6054 DT denotes the
T2833 6055-6063 NN denotes velocity
T2834 6064-6066 IN denotes of
T2835 6067-6070 DT denotes the
T2836 6071-6079 NN denotes reaction
T2837 6080-6083 VBD denotes did
T2838 6084-6087 RB denotes not
T2822 6088-6093 VB denotes reach
T2839 6094-6098 DT denotes that
T2840 6099-6107 VBN denotes observed
T2841 6108-6111 IN denotes for
T2842 6112-6115 NN denotes HKI
T2843 6116-6124 NN denotes activity
T2844 6125-6127 IN denotes in
T2845 6128-6131 DT denotes the
T2846 6132-6139 NN denotes absence
T2847 6140-6142 IN denotes of
T2848 6143-6148 NN denotes Cox11
T2849 6149-6150 -LRB- denotes (
T2851 6150-6156 NN denotes Figure
T2850 6157-6159 NN denotes 2A
T2852 6159-6160 -RRB- denotes )
T2853 6160-6162 , denotes ,
T2854 6162-6172 VBG denotes suggesting
T2855 6173-6176 DT denotes the
T2856 6177-6179 NN denotes LD
T2858 6180-6182 IN denotes by
T2859 6183-6189 PRP denotes itself
T2860 6190-6193 MD denotes may
T2861 6194-6198 RB denotes also
T2857 6199-6203 VB denotes have
T2862 6204-6206 DT denotes an
T2863 6207-6213 NN denotes effect
T2864 6214-6216 IN denotes on
T2865 6217-6220 NN denotes HKI
T2866 6221-6229 NN denotes activity
T2867 6229-6230 . denotes .
T2868 6230-6358 sentence denotes Indeed, a saturating concentration of LD reduced the V max but not the K m of HKI (Figure 2D) by ~20% under similar conditions.
T2869 6231-6237 RB denotes Indeed
T2871 6237-6239 , denotes ,
T2872 6239-6240 DT denotes a
T2874 6241-6251 NN denotes saturating
T2873 6252-6265 NN denotes concentration
T2875 6266-6268 IN denotes of
T2876 6269-6271 NN denotes LD
T2870 6272-6279 VBD denotes reduced
T2877 6280-6283 DT denotes the
T2878 6284-6289 NN denotes V max
T2879 6290-6293 CC denotes but
T2880 6294-6297 RB denotes not
T2881 6298-6301 DT denotes the
T2882 6302-6305 NN denotes K m
T2883 6306-6308 IN denotes of
T2884 6309-6312 NN denotes HKI
T2885 6313-6314 -LRB- denotes (
T2887 6314-6320 NN denotes Figure
T2886 6321-6323 NN denotes 2D
T2888 6323-6324 -RRB- denotes )
T2889 6325-6327 IN denotes by
T2890 6328-6329 SYM denotes ~
T2891 6329-6331 CD denotes 20
T2892 6331-6332 NN denotes %
T2893 6333-6338 IN denotes under
T2894 6339-6346 JJ denotes similar
T2895 6347-6357 NNS denotes conditions
T2896 6357-6358 . denotes .
T11520 6369-6375 NN denotes Effect
T11521 6376-6378 IN denotes of
T11522 6379-6384 NN denotes Cox11
T11523 6385-6388 CC denotes and
T11524 6389-6395 NN denotes RanBP2
T11525 6396-6398 IN denotes on
T11526 6399-6402 NN denotes HKI
T11527 6403-6411 NN denotes Activity
T11528 6411-6576 sentence denotes (A) Saturation kinetics, rate versus glucose of HKI (0.24 μg) in the absence (solid circles) and presence of Cox11 (open circles, 0.25 nM; solid triangles, 7.5 nM).
T11529 6412-6413 -LRB- denotes (
T11530 6413-6414 LS denotes A
T11532 6414-6415 -RRB- denotes )
T11533 6416-6426 NN denotes Saturation
T11531 6427-6435 NNS denotes kinetics
T11534 6435-6437 , denotes ,
T11535 6437-6441 NN denotes rate
T11536 6442-6448 CC denotes versus
T11537 6449-6456 NN denotes glucose
T11538 6457-6459 IN denotes of
T11539 6460-6463 NN denotes HKI
T11540 6464-6465 -LRB- denotes (
T11542 6465-6469 CD denotes 0.24
T11541 6470-6472 NNS denotes μg
T11543 6472-6473 -RRB- denotes )
T11544 6474-6476 IN denotes in
T11545 6477-6480 DT denotes the
T11546 6481-6488 NN denotes absence
T11547 6489-6490 -LRB- denotes (
T11549 6490-6495 JJ denotes solid
T11548 6496-6503 NNS denotes circles
T11550 6503-6504 -RRB- denotes )
T11551 6505-6508 CC denotes and
T11552 6509-6517 NN denotes presence
T11553 6518-6520 IN denotes of
T11554 6521-6526 NN denotes Cox11
T11555 6527-6528 -LRB- denotes (
T11557 6528-6532 JJ denotes open
T11558 6533-6540 NNS denotes circles
T11560 6540-6542 , denotes ,
T11561 6542-6546 CD denotes 0.25
T11559 6547-6549 NNS denotes nM
T11562 6549-6550 : denotes ;
T11563 6551-6556 JJ denotes solid
T11564 6557-6566 NNS denotes triangles
T11565 6566-6568 , denotes ,
T11566 6568-6571 CD denotes 7.5
T11556 6572-6574 NNS denotes nM
T11567 6574-6575 -RRB- denotes )
T11568 6575-6576 . denotes .
T11569 6576-6647 sentence denotes The activity of HKI decreases with increasing concentrations of Cox11.
T11570 6577-6580 DT denotes The
T11571 6581-6589 NN denotes activity
T11573 6590-6592 IN denotes of
T11574 6593-6596 NN denotes HKI
T11572 6597-6606 VBZ denotes decreases
T11575 6607-6611 IN denotes with
T11576 6612-6622 VBG denotes increasing
T11577 6623-6637 NNS denotes concentrations
T11578 6638-6640 IN denotes of
T11579 6641-6646 NN denotes Cox11
T11580 6646-6647 . denotes .
T11581 6647-6741 sentence denotes No measurable HKI activity was recorded in the presence of 15 nM of Cox11 (unpublished data).
T11582 6648-6650 DT denotes No
T11584 6651-6661 JJ denotes measurable
T11585 6662-6665 NN denotes HKI
T11583 6666-6674 NN denotes activity
T11587 6675-6678 VBD denotes was
T11586 6679-6687 VBN denotes recorded
T11588 6688-6690 IN denotes in
T11589 6691-6694 DT denotes the
T11590 6695-6703 NN denotes presence
T11591 6704-6706 IN denotes of
T11592 6707-6709 CD denotes 15
T11593 6710-6712 NNS denotes nM
T11594 6713-6715 IN denotes of
T11595 6716-6721 NN denotes Cox11
T11596 6722-6723 -LRB- denotes (
T11598 6723-6734 JJ denotes unpublished
T11597 6735-6739 NNS denotes data
T11599 6739-6740 -RRB- denotes )
T11600 6740-6741 . denotes .
T11601 6741-6854 sentence denotes (B) Hanes-Wolf plot of (A) (1/rate versus glucose) in the absence and presence of fixed concentrations of Cox11.
T11602 6742-6743 -LRB- denotes (
T11603 6743-6744 LS denotes B
T11605 6744-6745 -RRB- denotes )
T11606 6746-6751 NNP denotes Hanes
T11608 6751-6752 HYPH denotes -
T11607 6752-6756 NNP denotes Wolf
T11604 6757-6761 NN denotes plot
T11609 6762-6764 IN denotes of
T11610 6765-6766 -LRB- denotes (
T11611 6766-6767 NN denotes A
T11612 6767-6768 -RRB- denotes )
T11613 6769-6770 -LRB- denotes (
T11614 6770-6771 CD denotes 1
T11615 6771-6772 SYM denotes /
T11616 6772-6776 NN denotes rate
T11617 6777-6783 CC denotes versus
T11618 6784-6791 NN denotes glucose
T11619 6791-6792 -RRB- denotes )
T11620 6793-6795 IN denotes in
T11621 6796-6799 DT denotes the
T11622 6800-6807 NN denotes absence
T11623 6808-6811 CC denotes and
T11624 6812-6820 NN denotes presence
T11625 6821-6823 IN denotes of
T11626 6824-6829 VBN denotes fixed
T11627 6830-6844 NNS denotes concentrations
T11628 6845-6847 IN denotes of
T11629 6848-6853 NN denotes Cox11
T11630 6853-6854 . denotes .
T11631 6854-6960 sentence denotes Linearity of reciprocal plots also supported the hyperbolic behavior of the reactions (unpublished data).
T11632 6855-6864 NN denotes Linearity
T11634 6865-6867 IN denotes of
T11635 6868-6878 JJ denotes reciprocal
T11636 6879-6884 NNS denotes plots
T11637 6885-6889 RB denotes also
T11633 6890-6899 VBD denotes supported
T11638 6900-6903 DT denotes the
T11640 6904-6914 JJ denotes hyperbolic
T11639 6915-6923 NN denotes behavior
T11641 6924-6926 IN denotes of
T11642 6927-6930 DT denotes the
T11643 6931-6940 NNS denotes reactions
T11644 6941-6942 -LRB- denotes (
T11646 6942-6953 JJ denotes unpublished
T11645 6954-6958 NNS denotes data
T11647 6958-6959 -RRB- denotes )
T11648 6959-6960 . denotes .
T11649 6960-7072 sentence denotes Cox11 behaves as a noncompetitive inhibitor of HKI by reducing the V max of HKI but not its K m toward glucose.
T11650 6961-6966 NN denotes Cox11
T11651 6967-6974 VBZ denotes behaves
T11652 6975-6977 IN denotes as
T11653 6978-6979 DT denotes a
T11655 6980-6994 JJ denotes noncompetitive
T11654 6995-7004 NN denotes inhibitor
T11656 7005-7007 IN denotes of
T11657 7008-7011 NN denotes HKI
T11658 7012-7014 IN denotes by
T11659 7015-7023 VBG denotes reducing
T11660 7024-7027 DT denotes the
T11661 7028-7033 NN denotes V max
T11662 7034-7036 IN denotes of
T11663 7037-7040 NN denotes HKI
T11664 7041-7044 CC denotes but
T11665 7045-7048 RB denotes not
T11666 7049-7052 PRP$ denotes its
T11667 7053-7056 NN denotes K m
T11668 7057-7063 IN denotes toward
T11669 7064-7071 NN denotes glucose
T11670 7071-7072 . denotes .
T11671 7072-7193 sentence denotes (C) HKI rate is plotted as a function of LD concentration at saturating glucose and fixed Cox11 (7.5 nM) concentrations.
T11672 7073-7074 -LRB- denotes (
T11673 7074-7075 LS denotes C
T11675 7075-7076 -RRB- denotes )
T11676 7077-7080 NN denotes HKI
T11677 7081-7085 NN denotes rate
T11678 7086-7088 VBZ denotes is
T11674 7089-7096 VBN denotes plotted
T11679 7097-7099 IN denotes as
T11680 7100-7101 DT denotes a
T11681 7102-7110 NN denotes function
T11682 7111-7113 IN denotes of
T11683 7114-7116 NN denotes LD
T11684 7117-7130 NN denotes concentration
T11685 7131-7133 IN denotes at
T11686 7134-7144 VBG denotes saturating
T11687 7145-7152 NN denotes glucose
T11689 7153-7156 CC denotes and
T11690 7157-7162 VBN denotes fixed
T11691 7163-7168 NN denotes Cox11
T11692 7169-7170 -LRB- denotes (
T11694 7170-7173 CD denotes 7.5
T11693 7174-7176 NNS denotes nM
T11695 7176-7177 -RRB- denotes )
T11688 7178-7192 NNS denotes concentrations
T11696 7192-7193 . denotes .
T11697 7193-7298 sentence denotes Note that increasing concentrations of the LD of RanBP2 reverse the inhibition of HKI activity by Cox11.
T11698 7194-7198 VB denotes Note
T11699 7199-7203 IN denotes that
T11701 7204-7214 VBG denotes increasing
T11702 7215-7229 NNS denotes concentrations
T11703 7230-7232 IN denotes of
T11704 7233-7236 DT denotes the
T11705 7237-7239 NN denotes LD
T11706 7240-7242 IN denotes of
T11707 7243-7249 NN denotes RanBP2
T11700 7250-7257 VBP denotes reverse
T11708 7258-7261 DT denotes the
T11709 7262-7272 NN denotes inhibition
T11710 7273-7275 IN denotes of
T11711 7276-7279 NN denotes HKI
T11712 7280-7288 NN denotes activity
T11713 7289-7291 IN denotes by
T11714 7292-7297 NN denotes Cox11
T11715 7297-7298 . denotes .
T11716 7298-7442 sentence denotes A half-maximal effect of the LD of RanBP2 on HKI activity in the presence of 7.5 nM of Cox11 was observed at a concentration of ~0.05 nM of LD.
T11717 7299-7300 DT denotes A
T11719 7301-7305 RB denotes half
T11721 7305-7306 HYPH denotes -
T11720 7306-7313 JJ denotes maximal
T11718 7314-7320 NN denotes effect
T11723 7321-7323 IN denotes of
T11724 7324-7327 DT denotes the
T11725 7328-7330 NN denotes LD
T11726 7331-7333 IN denotes of
T11727 7334-7340 NN denotes RanBP2
T11728 7341-7343 IN denotes on
T11729 7344-7347 NN denotes HKI
T11730 7348-7356 NN denotes activity
T11731 7357-7359 IN denotes in
T11732 7360-7363 DT denotes the
T11733 7364-7372 NN denotes presence
T11734 7373-7375 IN denotes of
T11735 7376-7379 CD denotes 7.5
T11736 7380-7382 NNS denotes nM
T11737 7383-7385 IN denotes of
T11738 7386-7391 NN denotes Cox11
T11739 7392-7395 VBD denotes was
T11722 7396-7404 VBN denotes observed
T11740 7405-7407 IN denotes at
T11741 7408-7409 DT denotes a
T11742 7410-7423 NN denotes concentration
T11743 7424-7426 IN denotes of
T11744 7427-7428 SYM denotes ~
T11745 7428-7432 CD denotes 0.05
T11746 7433-7435 NNS denotes nM
T11747 7436-7438 IN denotes of
T11748 7439-7441 NN denotes LD
T11749 7441-7442 . denotes .
T11750 7442-7520 sentence denotes (D) Rate versus glucose plot in the absence and presence of the LD of RanBP2.
T11751 7443-7444 -LRB- denotes (
T11752 7444-7445 LS denotes D
T11754 7445-7446 -RRB- denotes )
T11755 7447-7451 NN denotes Rate
T11756 7452-7458 CC denotes versus
T11757 7459-7466 NN denotes glucose
T11753 7467-7471 NN denotes plot
T11758 7472-7474 IN denotes in
T11759 7475-7478 DT denotes the
T11760 7479-7486 NN denotes absence
T11761 7487-7490 CC denotes and
T11762 7491-7499 NN denotes presence
T11763 7500-7502 IN denotes of
T11764 7503-7506 DT denotes the
T11765 7507-7509 NN denotes LD
T11766 7510-7512 IN denotes of
T11767 7513-7519 NN denotes RanBP2
T11768 7519-7520 . denotes .
T11769 7520-7624 sentence denotes At a saturating concentration of the LD of RanBP2 (3.75 nM), the HKI activity was reduced by about 20%.
T11770 7521-7523 IN denotes At
T11772 7524-7525 DT denotes a
T11774 7526-7536 NN denotes saturating
T11773 7537-7550 NN denotes concentration
T11775 7551-7553 IN denotes of
T11776 7554-7557 DT denotes the
T11777 7558-7560 NN denotes LD
T11778 7561-7563 IN denotes of
T11779 7564-7570 NN denotes RanBP2
T11780 7571-7572 -LRB- denotes (
T11782 7572-7576 CD denotes 3.75
T11781 7577-7579 NNS denotes nM
T11783 7579-7580 -RRB- denotes )
T11784 7580-7582 , denotes ,
T11785 7582-7585 DT denotes the
T11787 7586-7589 NN denotes HKI
T11786 7590-7598 NN denotes activity
T11788 7599-7602 VBD denotes was
T11771 7603-7610 VBN denotes reduced
T11789 7611-7613 IN denotes by
T11790 7614-7619 IN denotes about
T11791 7620-7622 CD denotes 20
T11792 7622-7623 NN denotes %
T11793 7623-7624 . denotes .
T11794 7624-7645 sentence denotes v, rate; S, glucose.
T11795 7625-7626 NN denotes v
T11796 7626-7628 , denotes ,
T11797 7628-7632 NN denotes rate
T11798 7632-7633 : denotes ;
T11799 7634-7635 NN denotes S
T11800 7635-7637 , denotes ,
T11801 7637-7644 NN denotes glucose
T11802 7644-7645 . denotes .
T2996 7647-7653 NN denotes RanBP2
T2997 7654-7665 VBZ denotes Colocalizes
T2998 7666-7670 IN denotes with
T2999 7671-7674 NN denotes HK1
T3000 7674-7676 , denotes ,
T3001 7676-7681 NN denotes Cox11
T3002 7681-7683 , denotes ,
T3003 7683-7686 CC denotes and
T3004 7687-7693 NN denotes mHsp70
T3005 7694-7696 IN denotes in
T3006 7697-7700 DT denotes the
T3007 7701-7707 NN denotes Retina
T3008 7708-7711 CC denotes and
T3009 7712-7720 VBN denotes Cultured
T3010 7721-7728 NNS denotes Neurons
T3011 7728-7966 sentence denotes In addition to its presence at the vicinity of NPCs, we have shown previously that RanBP2 is localized to and abundant in the mitochondria-rich ellipsoid subcellular compartment of photosensory (photoreceptor) neurons of the retina [19].
T3012 7729-7731 IN denotes In
T3014 7732-7740 NN denotes addition
T3015 7741-7743 IN denotes to
T3016 7744-7747 PRP$ denotes its
T3017 7748-7756 NN denotes presence
T3018 7757-7759 IN denotes at
T3019 7760-7763 DT denotes the
T3020 7764-7772 NN denotes vicinity
T3021 7773-7775 IN denotes of
T3022 7776-7780 NNS denotes NPCs
T3023 7780-7782 , denotes ,
T3024 7782-7784 PRP denotes we
T3025 7785-7789 VBP denotes have
T3013 7790-7795 VBN denotes shown
T3026 7796-7806 RB denotes previously
T3027 7807-7811 IN denotes that
T3029 7812-7818 NN denotes RanBP2
T3028 7819-7821 VBZ denotes is
T3030 7822-7831 VBN denotes localized
T3031 7832-7834 IN denotes to
T3032 7835-7838 CC denotes and
T3033 7839-7847 JJ denotes abundant
T3035 7848-7850 IN denotes in
T3036 7851-7854 DT denotes the
T3037 7855-7867 NNS denotes mitochondria
T3039 7867-7868 HYPH denotes -
T3038 7868-7872 JJ denotes rich
T3040 7873-7882 JJ denotes ellipsoid
T3041 7883-7894 JJ denotes subcellular
T3034 7895-7906 NN denotes compartment
T3042 7907-7909 IN denotes of
T3043 7910-7922 NN denotes photosensory
T3045 7923-7924 -LRB- denotes (
T3046 7924-7937 NN denotes photoreceptor
T3047 7937-7938 -RRB- denotes )
T3044 7939-7946 NNS denotes neurons
T3048 7947-7949 IN denotes of
T3049 7950-7953 DT denotes the
T3050 7954-7960 NN denotes retina
T3051 7961-7962 -LRB- denotes [
T3052 7962-7964 CD denotes 19
T3053 7964-7965 -RRB- denotes ]
T3054 7965-7966 . denotes .
T3055 7966-8399 sentence denotes We extended the subcellular colocalization studies on RanBP2 and its novel partners by immunocytochemistry to determine if RanBP2, Cox11, HKI, and mHsp70 colocalize in hippocampal neurons (Figure 3A–3C), cerebral cortex neurons (Figure 3D–3F), ellipsoid (mitochondria-rich) subcellular compartments of photosensory neurons of the retina (Figure 3G–3O), and dissociated primary glia and neuron cultures from the brain (Figure 3P–3Z).
T3056 7967-7969 PRP denotes We
T3057 7970-7978 VBD denotes extended
T3058 7979-7982 DT denotes the
T3060 7983-7994 JJ denotes subcellular
T3061 7995-8009 NN denotes colocalization
T3059 8010-8017 NNS denotes studies
T3062 8018-8020 IN denotes on
T3063 8021-8027 NN denotes RanBP2
T3064 8028-8031 CC denotes and
T3065 8032-8035 PRP$ denotes its
T3067 8036-8041 JJ denotes novel
T3066 8042-8050 NNS denotes partners
T3068 8051-8053 IN denotes by
T3069 8054-8073 NN denotes immunocytochemistry
T3070 8074-8076 TO denotes to
T3071 8077-8086 VB denotes determine
T3072 8087-8089 IN denotes if
T3074 8090-8096 NN denotes RanBP2
T3075 8096-8098 , denotes ,
T3076 8098-8103 NN denotes Cox11
T3077 8103-8105 , denotes ,
T3078 8105-8108 NN denotes HKI
T3079 8108-8110 , denotes ,
T3080 8110-8113 CC denotes and
T3081 8114-8120 NN denotes mHsp70
T3073 8121-8131 VBP denotes colocalize
T3082 8132-8134 IN denotes in
T3083 8135-8146 JJ denotes hippocampal
T3084 8147-8154 NNS denotes neurons
T3085 8155-8156 -LRB- denotes (
T3087 8156-8162 NN denotes Figure
T3086 8163-8165 NN denotes 3A
T3088 8165-8166 SYM denotes –
T3089 8166-8168 NN denotes 3C
T3090 8168-8169 -RRB- denotes )
T3091 8169-8171 , denotes ,
T3092 8171-8179 JJ denotes cerebral
T3093 8180-8186 NN denotes cortex
T3094 8187-8194 NNS denotes neurons
T3095 8195-8196 -LRB- denotes (
T3097 8196-8202 NN denotes Figure
T3096 8203-8205 NN denotes 3D
T3098 8205-8206 SYM denotes –
T3099 8206-8208 NN denotes 3F
T3100 8208-8209 -RRB- denotes )
T3101 8209-8211 , denotes ,
T3102 8211-8220 JJ denotes ellipsoid
T3104 8221-8222 -LRB- denotes (
T3105 8222-8234 NNS denotes mitochondria
T3107 8234-8235 HYPH denotes -
T3106 8235-8239 JJ denotes rich
T3108 8239-8240 -RRB- denotes )
T3109 8241-8252 JJ denotes subcellular
T3103 8253-8265 NNS denotes compartments
T3110 8266-8268 IN denotes of
T3111 8269-8281 JJ denotes photosensory
T3112 8282-8289 NNS denotes neurons
T3113 8290-8292 IN denotes of
T3114 8293-8296 DT denotes the
T3115 8297-8303 NN denotes retina
T3116 8304-8305 -LRB- denotes (
T3118 8305-8311 NN denotes Figure
T3117 8312-8314 NN denotes 3G
T3119 8314-8315 SYM denotes –
T3120 8315-8317 NN denotes 3O
T3121 8317-8318 -RRB- denotes )
T3122 8318-8320 , denotes ,
T3123 8320-8323 CC denotes and
T3124 8324-8335 VBN denotes dissociated
T3126 8336-8343 JJ denotes primary
T3125 8344-8348 NN denotes glia
T3127 8349-8352 CC denotes and
T3128 8353-8359 NN denotes neuron
T3129 8360-8368 NNS denotes cultures
T3130 8369-8373 IN denotes from
T3131 8374-8377 DT denotes the
T3132 8378-8383 NN denotes brain
T3133 8384-8385 -LRB- denotes (
T3135 8385-8391 NN denotes Figure
T3134 8392-8394 NN denotes 3P
T3136 8394-8395 SYM denotes –
T3137 8395-8397 NN denotes 3Z
T3138 8397-8398 -RRB- denotes )
T3139 8398-8399 . denotes .
T3140 8399-8524 sentence denotes Double immunostaining with antibodies against these proteins showed that they colocalize to the mitochondria (Figure 3A–3Z).
T3141 8400-8406 JJ denotes Double
T3142 8407-8421 NN denotes immunostaining
T3144 8422-8426 IN denotes with
T3145 8427-8437 NNS denotes antibodies
T3146 8438-8445 IN denotes against
T3147 8446-8451 DT denotes these
T3148 8452-8460 NN denotes proteins
T3143 8461-8467 VBD denotes showed
T3149 8468-8472 IN denotes that
T3151 8473-8477 PRP denotes they
T3150 8478-8488 VBP denotes colocalize
T3152 8489-8491 IN denotes to
T3153 8492-8495 DT denotes the
T3154 8496-8508 NNS denotes mitochondria
T3155 8509-8510 -LRB- denotes (
T3157 8510-8516 NN denotes Figure
T3156 8517-8519 NN denotes 3A
T3158 8519-8520 SYM denotes –
T3159 8520-8522 NN denotes 3Z
T3160 8522-8523 -RRB- denotes )
T3161 8523-8524 . denotes .
T11945 8535-8547 NN denotes Localization
T11946 8548-8550 IN denotes of
T11947 8551-8557 NN denotes RanBP2
T11948 8558-8561 CC denotes and
T11949 8562-8565 PRP$ denotes Its
T11951 8566-8568 NN denotes LD
T11952 8569-8578 JJ denotes Molecular
T11950 8579-8587 NNS denotes Partners
T11953 8587-8785 sentence denotes (A–F) are thin cryosections of an area of the hipocampus (CA1 neurons) and cerebral cortex, respectively, immunostained against HKI (A and D), RanBP2 (B and E), and merged images thereof (C and F).
T11954 8588-8589 -LRB- denotes (
T11956 8589-8590 NN denotes A
T11957 8590-8591 SYM denotes –
T11958 8591-8592 NN denotes F
T11959 8592-8593 -RRB- denotes )
T11955 8594-8597 VBP denotes are
T11960 8598-8602 JJ denotes thin
T11961 8603-8615 NNS denotes cryosections
T11962 8616-8618 IN denotes of
T11963 8619-8621 DT denotes an
T11964 8622-8626 NN denotes area
T11965 8627-8629 IN denotes of
T11966 8630-8633 DT denotes the
T11967 8634-8644 NN denotes hipocampus
T11968 8645-8646 -LRB- denotes (
T11970 8646-8649 NN denotes CA1
T11969 8650-8657 NNS denotes neurons
T11971 8657-8658 -RRB- denotes )
T11972 8659-8662 CC denotes and
T11973 8663-8671 JJ denotes cerebral
T11974 8672-8678 NN denotes cortex
T11975 8678-8680 , denotes ,
T11976 8680-8692 RB denotes respectively
T11977 8692-8694 , denotes ,
T11978 8694-8707 VBN denotes immunostained
T11979 8708-8715 IN denotes against
T11980 8716-8719 NN denotes HKI
T11981 8720-8721 -LRB- denotes (
T11982 8721-8722 NN denotes A
T11983 8723-8726 CC denotes and
T11984 8727-8728 NN denotes D
T11985 8728-8729 -RRB- denotes )
T11986 8729-8731 , denotes ,
T11987 8731-8737 NN denotes RanBP2
T11988 8738-8739 -LRB- denotes (
T11989 8739-8740 NN denotes B
T11990 8741-8744 CC denotes and
T11991 8745-8746 NN denotes E
T11992 8746-8747 -RRB- denotes )
T11993 8747-8749 , denotes ,
T11994 8749-8752 CC denotes and
T11995 8753-8759 VBN denotes merged
T11996 8760-8766 NNS denotes images
T11997 8767-8774 RB denotes thereof
T11998 8775-8776 -LRB- denotes (
T11999 8776-8777 NN denotes C
T12000 8778-8781 CC denotes and
T12001 8782-8783 NN denotes F
T12002 8783-8784 -RRB- denotes )
T12003 8784-8785 . denotes .
T12004 8785-9003 sentence denotes Note that while RanBP2 and HKI are widely expressed among and colocalize to hippocampal neurons (C), HKI expression and localization with RanBP2 is restricted to a subset of cortical neurons (likely interneurons) (F).
T12005 8786-8790 VB denotes Note
T12006 8791-8795 IN denotes that
T12008 8796-8801 IN denotes while
T12010 8802-8808 NN denotes RanBP2
T12011 8809-8812 CC denotes and
T12012 8813-8816 NN denotes HKI
T12013 8817-8820 VBP denotes are
T12014 8821-8827 RB denotes widely
T12009 8828-8837 VBN denotes expressed
T12015 8838-8843 IN denotes among
T12016 8844-8847 CC denotes and
T12017 8848-8858 VBP denotes colocalize
T12018 8859-8861 IN denotes to
T12019 8862-8873 JJ denotes hippocampal
T12020 8874-8881 NNS denotes neurons
T12021 8882-8883 -LRB- denotes (
T12022 8883-8884 NN denotes C
T12023 8884-8885 -RRB- denotes )
T12024 8885-8887 , denotes ,
T12025 8887-8890 NN denotes HKI
T12026 8891-8901 NN denotes expression
T12027 8902-8905 CC denotes and
T12028 8906-8918 NN denotes localization
T12029 8919-8923 IN denotes with
T12030 8924-8930 NN denotes RanBP2
T12031 8931-8933 VBZ denotes is
T12007 8934-8944 VBN denotes restricted
T12032 8945-8947 IN denotes to
T12033 8948-8949 DT denotes a
T12034 8950-8956 NN denotes subset
T12035 8957-8959 IN denotes of
T12036 8960-8968 JJ denotes cortical
T12037 8969-8976 NNS denotes neurons
T12038 8977-8978 -LRB- denotes (
T12039 8978-8984 JJ denotes likely
T12040 8985-8997 NNS denotes interneurons
T12041 8997-8998 -RRB- denotes )
T12042 8999-9000 -LRB- denotes (
T12043 9000-9001 NN denotes F
T12044 9001-9002 -RRB- denotes )
T12045 9002-9003 . denotes .
T12046 9003-9323 sentence denotes Images of the distal region of bovine retinal cryosections comprising part of the nuclear layer of photoreceptor neurons and their inner (myoid and ellipsoid) segment compartment (G–O) are immunostained against mHsp70 (G) and RanBP2 (H), mHsp70 (J) and Cox11 (K), HKI (M) and Cox11 (N), and merged images thereof (I–O).
T12047 9004-9010 NNS denotes Images
T12049 9011-9013 IN denotes of
T12050 9014-9017 DT denotes the
T12052 9018-9024 JJ denotes distal
T12051 9025-9031 NN denotes region
T12053 9032-9034 IN denotes of
T12054 9035-9041 JJ denotes bovine
T12056 9042-9049 JJ denotes retinal
T12055 9050-9062 NNS denotes cryosections
T12057 9063-9073 VBG denotes comprising
T12058 9074-9078 NN denotes part
T12059 9079-9081 IN denotes of
T12060 9082-9085 DT denotes the
T12062 9086-9093 JJ denotes nuclear
T12061 9094-9099 NN denotes layer
T12063 9100-9102 IN denotes of
T12064 9103-9116 NN denotes photoreceptor
T12065 9117-9124 NNS denotes neurons
T12066 9125-9128 CC denotes and
T12067 9129-9134 PRP$ denotes their
T12069 9135-9140 JJ denotes inner
T12070 9141-9142 -LRB- denotes (
T12071 9142-9147 JJ denotes myoid
T12072 9148-9151 CC denotes and
T12073 9152-9161 JJ denotes ellipsoid
T12074 9161-9162 -RRB- denotes )
T12075 9163-9170 NN denotes segment
T12068 9171-9182 NN denotes compartment
T12076 9183-9184 -LRB- denotes (
T12077 9184-9185 NN denotes G
T12078 9185-9186 SYM denotes –
T12079 9186-9187 NN denotes O
T12080 9187-9188 -RRB- denotes )
T12081 9189-9192 VBP denotes are
T12048 9193-9206 VBN denotes immunostained
T12082 9207-9214 IN denotes against
T12083 9215-9221 NN denotes mHsp70
T12084 9222-9223 -LRB- denotes (
T12085 9223-9224 NN denotes G
T12086 9224-9225 -RRB- denotes )
T12087 9226-9229 CC denotes and
T12088 9230-9236 NN denotes RanBP2
T12089 9237-9238 -LRB- denotes (
T12090 9238-9239 NN denotes H
T12091 9239-9240 -RRB- denotes )
T12092 9240-9242 , denotes ,
T12093 9242-9248 NN denotes mHsp70
T12094 9249-9250 -LRB- denotes (
T12095 9250-9251 NN denotes J
T12096 9251-9252 -RRB- denotes )
T12097 9253-9256 CC denotes and
T12098 9257-9262 NN denotes Cox11
T12099 9263-9264 -LRB- denotes (
T12100 9264-9265 NN denotes K
T12101 9265-9266 -RRB- denotes )
T12102 9266-9268 , denotes ,
T12103 9268-9271 NN denotes HKI
T12104 9272-9273 -LRB- denotes (
T12105 9273-9274 NN denotes M
T12106 9274-9275 -RRB- denotes )
T12107 9276-9279 CC denotes and
T12108 9280-9285 NN denotes Cox11
T12109 9286-9287 -LRB- denotes (
T12110 9287-9288 NN denotes N
T12111 9288-9289 -RRB- denotes )
T12112 9289-9291 , denotes ,
T12113 9291-9294 CC denotes and
T12114 9295-9301 VBN denotes merged
T12115 9302-9308 NNS denotes images
T12116 9309-9316 RB denotes thereof
T12117 9317-9318 -LRB- denotes (
T12118 9318-9319 NN denotes I
T12119 9319-9320 SYM denotes –
T12120 9320-9321 NN denotes O
T12121 9321-9322 -RRB- denotes )
T12122 9322-9323 . denotes .
T12123 9323-9599 sentence denotes Note the prominent localization of RanBP2, mHsp70, and Cox11 at the mitochondria-rich ellipsoid compartment of photoreceptors and the colocalization of RanBP2 and Cox11 with mHsp70 (I and L), while HKI colocalization with Cox11 was limited to restricted foci (R, arrowheads).
T12124 9324-9328 VB denotes Note
T12125 9329-9332 DT denotes the
T12127 9333-9342 JJ denotes prominent
T12126 9343-9355 NN denotes localization
T12128 9356-9358 IN denotes of
T12129 9359-9365 NN denotes RanBP2
T12130 9365-9367 , denotes ,
T12131 9367-9373 NN denotes mHsp70
T12132 9373-9375 , denotes ,
T12133 9375-9378 CC denotes and
T12134 9379-9384 NN denotes Cox11
T12135 9385-9387 IN denotes at
T12136 9388-9391 DT denotes the
T12138 9392-9404 NNS denotes mitochondria
T12140 9404-9405 HYPH denotes -
T12139 9405-9409 JJ denotes rich
T12141 9410-9419 JJ denotes ellipsoid
T12137 9420-9431 NN denotes compartment
T12142 9432-9434 IN denotes of
T12143 9435-9449 NNS denotes photoreceptors
T12144 9450-9453 CC denotes and
T12145 9454-9457 DT denotes the
T12146 9458-9472 NN denotes colocalization
T12147 9473-9475 IN denotes of
T12148 9476-9482 NN denotes RanBP2
T12149 9483-9486 CC denotes and
T12150 9487-9492 NN denotes Cox11
T12151 9493-9497 IN denotes with
T12152 9498-9504 NN denotes mHsp70
T12153 9505-9506 -LRB- denotes (
T12154 9506-9507 NN denotes I
T12155 9508-9511 CC denotes and
T12156 9512-9513 NN denotes L
T12157 9513-9514 -RRB- denotes )
T12158 9514-9516 , denotes ,
T12159 9516-9521 IN denotes while
T12161 9522-9525 NN denotes HKI
T12162 9526-9540 NN denotes colocalization
T12163 9541-9545 IN denotes with
T12164 9546-9551 NN denotes Cox11
T12165 9552-9555 VBD denotes was
T12160 9556-9563 VBN denotes limited
T12166 9564-9566 IN denotes to
T12167 9567-9577 VBN denotes restricted
T12168 9578-9582 NNS denotes foci
T12169 9583-9584 -LRB- denotes (
T12171 9584-9585 NN denotes R
T12172 9585-9587 , denotes ,
T12170 9587-9597 NNS denotes arrowheads
T12173 9597-9598 -RRB- denotes )
T12174 9598-9599 . denotes .
T12175 9599-9828 sentence denotes High-resolution images of dissociated primary cerebral neurons and glial cells confirmed that the colocalization of HKI and Cox11 was highly restricted (P–R), while RanBP2 extensively colocalized with HKI (S–U) and mHsp70 (V–Z).
T12176 9600-9604 JJ denotes High
T12178 9604-9605 HYPH denotes -
T12177 9605-9615 NN denotes resolution
T12179 9616-9622 NNS denotes images
T12181 9623-9625 IN denotes of
T12182 9626-9637 VBN denotes dissociated
T12184 9638-9645 JJ denotes primary
T12185 9646-9654 JJ denotes cerebral
T12183 9655-9662 NNS denotes neurons
T12186 9663-9666 CC denotes and
T12187 9667-9672 JJ denotes glial
T12188 9673-9678 NNS denotes cells
T12180 9679-9688 VBD denotes confirmed
T12189 9689-9693 IN denotes that
T12191 9694-9697 DT denotes the
T12192 9698-9712 NN denotes colocalization
T12193 9713-9715 IN denotes of
T12194 9716-9719 NN denotes HKI
T12195 9720-9723 CC denotes and
T12196 9724-9729 NN denotes Cox11
T12190 9730-9733 VBD denotes was
T12197 9734-9740 RB denotes highly
T12198 9741-9751 JJ denotes restricted
T12199 9752-9753 -LRB- denotes (
T12200 9753-9754 NN denotes P
T12201 9754-9755 SYM denotes –
T12202 9755-9756 NN denotes R
T12203 9756-9757 -RRB- denotes )
T12204 9757-9759 , denotes ,
T12205 9759-9764 IN denotes while
T12207 9765-9771 NN denotes RanBP2
T12208 9772-9783 RB denotes extensively
T12206 9784-9795 VBD denotes colocalized
T12209 9796-9800 IN denotes with
T12210 9801-9804 NN denotes HKI
T12211 9805-9806 -LRB- denotes (
T12212 9806-9807 NN denotes S
T12213 9807-9808 SYM denotes –
T12214 9808-9809 NN denotes U
T12215 9809-9810 -RRB- denotes )
T12216 9811-9814 CC denotes and
T12217 9815-9821 NN denotes mHsp70
T12218 9822-9823 -LRB- denotes (
T12219 9823-9824 NN denotes V
T12220 9824-9825 SYM denotes –
T12221 9825-9826 NN denotes Z
T12222 9826-9827 -RRB- denotes )
T12223 9827-9828 . denotes .
T12224 9828-9886 sentence denotes Scale bars in A–O and P–Z are 40 and 10 μm, respectively.
T12225 9829-9834 NN denotes Scale
T12226 9835-9839 NNS denotes bars
T12228 9840-9842 IN denotes in
T12229 9843-9844 NN denotes A
T12230 9844-9845 SYM denotes –
T12231 9845-9846 NN denotes O
T12232 9847-9850 CC denotes and
T12233 9851-9852 NN denotes P
T12234 9852-9853 SYM denotes –
T12235 9853-9854 NN denotes Z
T12227 9855-9858 VBP denotes are
T12236 9859-9861 CD denotes 40
T12238 9862-9865 CC denotes and
T12239 9866-9868 CD denotes 10
T12237 9869-9871 NNS denotes μm
T12240 9871-9873 , denotes ,
T12241 9873-9885 RB denotes respectively
T12242 9885-9886 . denotes .
T12243 9886-9912 sentence denotes ONL, outer nuclear layer.
T12244 9887-9890 NN denotes ONL
T12245 9890-9892 , denotes ,
T12246 9892-9897 JJ denotes outer
T12248 9898-9905 JJ denotes nuclear
T12247 9906-9911 NN denotes layer
T12249 9911-9912 . denotes .
T3449 9914-9932 NN denotes Haploinsufficiency
T3451 9933-9935 IN denotes of
T3452 9936-9942 NN denotes RanBP2
T3450 9943-9949 VBZ denotes Causes
T3453 9950-9959 VBN denotes Decreased
T3454 9960-9966 NNS denotes Levels
T3455 9967-9969 IN denotes of
T3456 9970-9973 NN denotes HKI
T3457 9974-9977 CC denotes and
T3458 9978-9985 JJ denotes Partial
T3459 9986-10001 NN denotes Mislocalization
T3460 10002-10004 IN denotes of
T3461 10005-10008 NN denotes HKI
T3462 10008-10323 sentence denotes To determine the physiological implications of the interaction between RanBP2 and HKI (and other partners), we employed a murine embryonic stem 129Ola cell line with a targeted RanBP2 locus produced by gene-trapping to produce stable inbred (coisogenic) and mixed background lines, respectively (Figure 4A and 4B).
T3463 10009-10011 TO denotes To
T3464 10012-10021 VB denotes determine
T3466 10022-10025 DT denotes the
T3468 10026-10039 JJ denotes physiological
T3467 10040-10052 NNS denotes implications
T3469 10053-10055 IN denotes of
T3470 10056-10059 DT denotes the
T3471 10060-10071 NN denotes interaction
T3472 10072-10079 IN denotes between
T3473 10080-10086 NN denotes RanBP2
T3474 10087-10090 CC denotes and
T3475 10091-10094 NN denotes HKI
T3476 10095-10096 -LRB- denotes (
T3477 10096-10099 CC denotes and
T3478 10100-10105 JJ denotes other
T3479 10106-10114 NNS denotes partners
T3480 10114-10115 -RRB- denotes )
T3481 10115-10117 , denotes ,
T3482 10117-10119 PRP denotes we
T3465 10120-10128 VBD denotes employed
T3483 10129-10130 DT denotes a
T3485 10131-10137 JJ denotes murine
T3486 10138-10147 JJ denotes embryonic
T3487 10148-10152 NN denotes stem
T3488 10153-10159 NN denotes 129Ola
T3489 10160-10164 NN denotes cell
T3484 10165-10169 NN denotes line
T3490 10170-10174 IN denotes with
T3491 10175-10176 DT denotes a
T3493 10177-10185 VBN denotes targeted
T3494 10186-10192 NN denotes RanBP2
T3492 10193-10198 NN denotes locus
T3495 10199-10207 VBN denotes produced
T3496 10208-10210 IN denotes by
T3497 10211-10215 NN denotes gene
T3499 10215-10216 HYPH denotes -
T3498 10216-10224 NN denotes trapping
T3500 10225-10227 TO denotes to
T3501 10228-10235 VB denotes produce
T3502 10236-10242 JJ denotes stable
T3504 10243-10249 JJ denotes inbred
T3505 10250-10251 -LRB- denotes (
T3506 10251-10261 JJ denotes coisogenic
T3507 10261-10262 -RRB- denotes )
T3508 10263-10266 CC denotes and
T3509 10267-10272 JJ denotes mixed
T3510 10273-10283 NN denotes background
T3503 10284-10289 NNS denotes lines
T3511 10289-10291 , denotes ,
T3512 10291-10303 RB denotes respectively
T3513 10304-10305 -LRB- denotes (
T3515 10305-10311 NN denotes Figure
T3514 10312-10314 NN denotes 4A
T3516 10315-10318 CC denotes and
T3517 10319-10321 NN denotes 4B
T3518 10321-10322 -RRB- denotes )
T3519 10322-10323 . denotes .
T3520 10323-10531 sentence denotes Genotyping of 299 F2 offspring revealed a RanBP2+/+:RanBP2+/−:RanBP2−/− distribution (89:210:0) that deviated from the expected Mendelian ratio and supports that the RanBP2−/− mice were embryonically lethal.
T3521 10324-10334 NN denotes Genotyping
T3523 10335-10337 IN denotes of
T3524 10338-10341 CD denotes 299
T3525 10342-10344 NN denotes F2
T3526 10345-10354 NN denotes offspring
T3522 10355-10363 VBD denotes revealed
T3527 10364-10365 DT denotes a
T3529 10366-10372 NN denotes RanBP2
T3530 10372-10373 SYM denotes +
T3531 10373-10374 HYPH denotes /
T3532 10374-10375 SYM denotes +
T3533 10375-10376 SYM denotes :
T3534 10376-10382 NN denotes RanBP2
T3535 10382-10383 SYM denotes +
T3536 10383-10384 HYPH denotes /
T3537 10384-10385 SYM denotes −
T3538 10385-10386 SYM denotes :
T3539 10386-10392 NN denotes RanBP2
T3540 10392-10393 SYM denotes −
T3541 10393-10394 HYPH denotes /
T3542 10394-10395 SYM denotes −
T3528 10396-10408 NN denotes distribution
T3543 10409-10410 -LRB- denotes (
T3544 10410-10412 CD denotes 89
T3546 10412-10413 SYM denotes :
T3547 10413-10416 CD denotes 210
T3548 10416-10417 SYM denotes :
T3545 10417-10418 CD denotes 0
T3549 10418-10419 -RRB- denotes )
T3550 10420-10424 WDT denotes that
T3551 10425-10433 VBD denotes deviated
T3552 10434-10438 IN denotes from
T3553 10439-10442 DT denotes the
T3555 10443-10451 VBN denotes expected
T3556 10452-10461 JJ denotes Mendelian
T3554 10462-10467 NN denotes ratio
T3557 10468-10471 CC denotes and
T3558 10472-10480 VBZ denotes supports
T3559 10481-10485 IN denotes that
T3561 10486-10489 DT denotes the
T3563 10490-10496 NN denotes RanBP2
T3564 10496-10497 SYM denotes −
T3565 10497-10498 HYPH denotes /
T3566 10498-10499 SYM denotes −
T3562 10500-10504 NNS denotes mice
T3560 10505-10509 VBD denotes were
T3567 10510-10523 RB denotes embryonically
T3568 10524-10530 JJ denotes lethal
T3569 10530-10531 . denotes .
T3570 10531-10697 sentence denotes E12.5 embryos show strong expression of RanBP2 in the optic vesicle and throughout much of the embryo, which had no apparent developmental abnormalities (Figure 4C).
T3571 10532-10537 NN denotes E12.5
T3572 10538-10545 NNS denotes embryos
T3573 10546-10550 VBP denotes show
T3574 10551-10557 JJ denotes strong
T3575 10558-10568 NN denotes expression
T3576 10569-10571 IN denotes of
T3577 10572-10578 NN denotes RanBP2
T3578 10579-10581 IN denotes in
T3579 10582-10585 DT denotes the
T3581 10586-10591 JJ denotes optic
T3580 10592-10599 NN denotes vesicle
T3582 10600-10603 CC denotes and
T3583 10604-10614 IN denotes throughout
T3584 10615-10619 JJ denotes much
T3585 10620-10622 IN denotes of
T3586 10623-10626 DT denotes the
T3587 10627-10633 NN denotes embryo
T3588 10633-10635 , denotes ,
T3589 10635-10640 WDT denotes which
T3590 10641-10644 VBD denotes had
T3591 10645-10647 DT denotes no
T3593 10648-10656 JJ denotes apparent
T3594 10657-10670 JJ denotes developmental
T3592 10671-10684 NNS denotes abnormalities
T3595 10685-10686 -LRB- denotes (
T3597 10686-10692 NN denotes Figure
T3596 10693-10695 NN denotes 4C
T3598 10695-10696 -RRB- denotes )
T3599 10696-10697 . denotes .
T3600 10697-10913 sentence denotes In agreement with previous immunocytochemistry analysis [19], the RanBP2 gene is expressed across mature retinal neurons, but expression in ganglion cells of the adult retina was extremely strong (Figure 4D and 4E).
T3601 10698-10700 IN denotes In
T3603 10701-10710 NN denotes agreement
T3604 10711-10715 IN denotes with
T3605 10716-10724 JJ denotes previous
T3607 10725-10744 NN denotes immunocytochemistry
T3606 10745-10753 NN denotes analysis
T3608 10754-10755 -LRB- denotes [
T3609 10755-10757 CD denotes 19
T3610 10757-10758 -RRB- denotes ]
T3611 10758-10760 , denotes ,
T3612 10760-10763 DT denotes the
T3614 10764-10770 NN denotes RanBP2
T3613 10771-10775 NN denotes gene
T3615 10776-10778 VBZ denotes is
T3602 10779-10788 VBN denotes expressed
T3616 10789-10795 IN denotes across
T3617 10796-10802 JJ denotes mature
T3619 10803-10810 JJ denotes retinal
T3618 10811-10818 NNS denotes neurons
T3620 10818-10820 , denotes ,
T3621 10820-10823 CC denotes but
T3622 10824-10834 NN denotes expression
T3624 10835-10837 IN denotes in
T3625 10838-10846 NN denotes ganglion
T3626 10847-10852 NNS denotes cells
T3627 10853-10855 IN denotes of
T3628 10856-10859 DT denotes the
T3630 10860-10865 JJ denotes adult
T3629 10866-10872 NN denotes retina
T3623 10873-10876 VBD denotes was
T3631 10877-10886 RB denotes extremely
T3632 10887-10893 JJ denotes strong
T3633 10894-10895 -LRB- denotes (
T3635 10895-10901 NN denotes Figure
T3634 10902-10904 NN denotes 4D
T3636 10905-10908 CC denotes and
T3637 10909-10911 NN denotes 4E
T3638 10911-10912 -RRB- denotes )
T3639 10912-10913 . denotes .
T3640 10913-13320 sentence denotes Figure 4 Insertion Mutagenesis of the Murine RanBP2 Gene (A) Diagram of the genomic region of RanBP2 disrupted by insertion trap mutagenesis with a bicistronic reporter vector between exon 1 and 2. The bicistronic transcript produces two proteins under regulation of RanBP2. Upon splicing of RanBP2, a fusion between exon 1 and β-geo (a fusion between the β-gal and neo genes) is generated, while human placental alkaline phophatase (PLAP) is independently translated using the internal ribosome entry site. Consistent with previous studies, the expression of the former is directed to cell bodies, while expression of the latter is targeted to the axonal processes [67,68]. Transcriptional 5′ RACE analysis detects a fusion between exon 1 and β-geo. (B) Southern analysis of the RanBP2 locus of wild-type and heterozygous genomic DNA of tails of F1 mice digested with PpuMI (left panel) and HindIII (right panel) with probes at the 3′ (left panel) and 5′ (right panel) flanking regions of the insertion breakpoint. Q1 is a cosmid containing the RanBP2 gene up to exon 20 [4]. (C) Lateroventral view of a whole-mount stain of a ~12.5 dpc heterozygous embryo for PLAP and β-gal (inset picture) activities. Although PLAP was broadly expressed (e.g., somites, limbs, and CNS), the PLAP and β-Gal (inset picture) expression was particularly high in the optic vesicle (arrow). X-gal single (D) and combined staining with PLAP (E) of a retinal section of a 3-mo-old RanBP2+/− mouse. Consistent with previous immunocytochemistry studies, β-Gal activity is detected in the neuroretinal bodies and inner segment compartment of photoreceptors with conspicuously strong expression in ganglion cells. PLAP expression is found throughout the plexiform/synaptic layers and outer segment of photoreceptors (E). GC, ganglion cell; PLAP, human placental alkaline phophatase; ROS, rod outer segment; RIS, rod inner segment; ONL, outer nuclear layer; OPL, outer plexiform (synaptic) layer; INL, inner nuclear layer; IPL, inner plexiform (synaptic) layer; GC, ganglion cell layer. In light of the association in vivo of RanBP2 with Cox11 and HKI (Figures 1 and 3), profound in vitro modulation of HKI enzymatic activity by RanBP2 and Cox11 (Figure 2), and the critical role of HKI in catalyzing a rate-limiting step of glycolysis, we probed whether RanBP2+/− mice presented disturbances in HKI, Cox11, and energy homeostasis.
T12535 10924-10933 NN denotes Insertion
T12536 10934-10945 NN denotes Mutagenesis
T12537 10946-10948 IN denotes of
T12538 10949-10952 DT denotes the
T12540 10953-10959 JJ denotes Murine
T12541 10960-10966 NN denotes RanBP2
T12539 10967-10971 NN denotes Gene
T12542 10971-11112 sentence denotes (A) Diagram of the genomic region of RanBP2 disrupted by insertion trap mutagenesis with a bicistronic reporter vector between exon 1 and 2.
T12543 10972-10973 -LRB- denotes (
T12544 10973-10974 LS denotes A
T12546 10974-10975 -RRB- denotes )
T12545 10976-10983 NN denotes Diagram
T12547 10984-10986 IN denotes of
T12548 10987-10990 DT denotes the
T12550 10991-10998 JJ denotes genomic
T12549 10999-11005 NN denotes region
T12551 11006-11008 IN denotes of
T12552 11009-11015 NN denotes RanBP2
T12553 11016-11025 VBN denotes disrupted
T12554 11026-11028 IN denotes by
T12555 11029-11038 NN denotes insertion
T12556 11039-11043 NN denotes trap
T12557 11044-11055 NN denotes mutagenesis
T12558 11056-11060 IN denotes with
T12559 11061-11062 DT denotes a
T12561 11063-11074 JJ denotes bicistronic
T12562 11075-11083 NN denotes reporter
T12560 11084-11090 NN denotes vector
T12563 11091-11098 IN denotes between
T12564 11099-11103 NN denotes exon
T12565 11104-11105 CD denotes 1
T12566 11106-11109 CC denotes and
T12567 11110-11111 CD denotes 2
T12568 11111-11112 . denotes .
T12569 11112-11189 sentence denotes The bicistronic transcript produces two proteins under regulation of RanBP2.
T12570 11113-11116 DT denotes The
T12572 11117-11128 JJ denotes bicistronic
T12571 11129-11139 NN denotes transcript
T12573 11140-11148 VBZ denotes produces
T12574 11149-11152 CD denotes two
T12575 11153-11161 NN denotes proteins
T12576 11162-11167 IN denotes under
T12577 11168-11178 NN denotes regulation
T12578 11179-11181 IN denotes of
T12579 11182-11188 NN denotes RanBP2
T12580 11188-11189 . denotes .
T12581 11189-11422 sentence denotes Upon splicing of RanBP2, a fusion between exon 1 and β-geo (a fusion between the β-gal and neo genes) is generated, while human placental alkaline phophatase (PLAP) is independently translated using the internal ribosome entry site.
T12582 11190-11194 IN denotes Upon
T12584 11195-11203 NN denotes splicing
T12585 11204-11206 IN denotes of
T12586 11207-11213 NN denotes RanBP2
T12587 11213-11215 , denotes ,
T12588 11215-11216 DT denotes a
T12589 11217-11223 NN denotes fusion
T12590 11224-11231 IN denotes between
T12591 11232-11236 NN denotes exon
T12592 11237-11238 CD denotes 1
T12593 11239-11242 CC denotes and
T12594 11243-11244 NN denotes β
T12596 11244-11245 HYPH denotes -
T12595 11245-11248 NN denotes geo
T12597 11249-11250 -LRB- denotes (
T12598 11250-11251 DT denotes a
T12599 11252-11258 NN denotes fusion
T12600 11259-11266 IN denotes between
T12601 11267-11270 DT denotes the
T12603 11271-11272 NN denotes β
T12605 11272-11273 HYPH denotes -
T12604 11273-11276 NN denotes gal
T12606 11277-11280 CC denotes and
T12607 11281-11284 NN denotes neo
T12602 11285-11290 NNS denotes genes
T12608 11290-11291 -RRB- denotes )
T12609 11292-11294 VBZ denotes is
T12583 11295-11304 VBN denotes generated
T12610 11304-11306 , denotes ,
T12611 11306-11311 IN denotes while
T12613 11312-11317 JJ denotes human
T12615 11318-11327 JJ denotes placental
T12616 11328-11336 NN denotes alkaline
T12614 11337-11347 NN denotes phophatase
T12617 11348-11349 -LRB- denotes (
T12618 11349-11353 NN denotes PLAP
T12619 11353-11354 -RRB- denotes )
T12620 11355-11357 VBZ denotes is
T12621 11358-11371 RB denotes independently
T12612 11372-11382 VBN denotes translated
T12622 11383-11388 VBG denotes using
T12623 11389-11392 DT denotes the
T12625 11393-11401 JJ denotes internal
T12627 11402-11410 NN denotes ribosome
T12626 11411-11416 NN denotes entry
T12624 11417-11421 NN denotes site
T12628 11421-11422 . denotes .
T12629 11422-11589 sentence denotes Consistent with previous studies, the expression of the former is directed to cell bodies, while expression of the latter is targeted to the axonal processes [67,68].
T12630 11423-11433 JJ denotes Consistent
T12632 11434-11438 IN denotes with
T12633 11439-11447 JJ denotes previous
T12634 11448-11455 NNS denotes studies
T12635 11455-11457 , denotes ,
T12636 11457-11460 DT denotes the
T12637 11461-11471 NN denotes expression
T12638 11472-11474 IN denotes of
T12639 11475-11478 DT denotes the
T12640 11479-11485 JJ denotes former
T12641 11486-11488 VBZ denotes is
T12631 11489-11497 VBN denotes directed
T12642 11498-11500 IN denotes to
T12643 11501-11505 NN denotes cell
T12644 11506-11512 NNS denotes bodies
T12645 11512-11514 , denotes ,
T12646 11514-11519 IN denotes while
T12648 11520-11530 NN denotes expression
T12649 11531-11533 IN denotes of
T12650 11534-11537 DT denotes the
T12651 11538-11544 JJ denotes latter
T12652 11545-11547 VBZ denotes is
T12647 11548-11556 VBN denotes targeted
T12653 11557-11559 IN denotes to
T12654 11560-11563 DT denotes the
T12656 11564-11570 JJ denotes axonal
T12655 11571-11580 NNS denotes processes
T12657 11581-11582 -LRB- denotes [
T12659 11582-11584 CD denotes 67
T12660 11584-11585 , denotes ,
T12658 11585-11587 CD denotes 68
T12661 11587-11588 -RRB- denotes ]
T12662 11588-11589 . denotes .
T12663 11589-11665 sentence denotes Transcriptional 5′ RACE analysis detects a fusion between exon 1 and β-geo.
T12664 11590-11605 JJ denotes Transcriptional
T12666 11606-11607 CD denotes 5
T12667 11607-11608 SYM denotes ′
T12668 11609-11613 NN denotes RACE
T12665 11614-11622 NN denotes analysis
T12669 11623-11630 VBZ denotes detects
T12670 11631-11632 DT denotes a
T12671 11633-11639 NN denotes fusion
T12672 11640-11647 IN denotes between
T12673 11648-11652 NN denotes exon
T12674 11653-11654 CD denotes 1
T12675 11655-11658 CC denotes and
T12676 11659-11660 NN denotes β
T12678 11660-11661 HYPH denotes -
T12677 11661-11664 NN denotes geo
T12679 11664-11665 . denotes .
T12680 11665-11930 sentence denotes (B) Southern analysis of the RanBP2 locus of wild-type and heterozygous genomic DNA of tails of F1 mice digested with PpuMI (left panel) and HindIII (right panel) with probes at the 3′ (left panel) and 5′ (right panel) flanking regions of the insertion breakpoint.
T12681 11666-11667 -LRB- denotes (
T12682 11667-11668 LS denotes B
T12684 11668-11669 -RRB- denotes )
T12685 11670-11678 NNP denotes Southern
T12683 11679-11687 NN denotes analysis
T12686 11688-11690 IN denotes of
T12687 11691-11694 DT denotes the
T12689 11695-11701 NN denotes RanBP2
T12688 11702-11707 NN denotes locus
T12690 11708-11710 IN denotes of
T12691 11711-11715 JJ denotes wild
T12693 11715-11716 HYPH denotes -
T12692 11716-11720 NN denotes type
T12695 11721-11724 CC denotes and
T12696 11725-11737 JJ denotes heterozygous
T12697 11738-11745 JJ denotes genomic
T12694 11746-11749 NN denotes DNA
T12698 11750-11752 IN denotes of
T12699 11753-11758 NNS denotes tails
T12700 11759-11761 IN denotes of
T12701 11762-11764 NN denotes F1
T12702 11765-11769 NNS denotes mice
T12703 11770-11778 VBN denotes digested
T12704 11779-11783 IN denotes with
T12705 11784-11789 NN denotes PpuMI
T12706 11790-11791 -LRB- denotes (
T12708 11791-11795 JJ denotes left
T12707 11796-11801 NN denotes panel
T12709 11801-11802 -RRB- denotes )
T12710 11803-11806 CC denotes and
T12711 11807-11814 NN denotes HindIII
T12712 11815-11816 -LRB- denotes (
T12714 11816-11821 JJ denotes right
T12713 11822-11827 NN denotes panel
T12715 11827-11828 -RRB- denotes )
T12716 11829-11833 IN denotes with
T12717 11834-11840 NNS denotes probes
T12718 11841-11843 IN denotes at
T12719 11844-11847 DT denotes the
T12721 11848-11849 CD denotes 3
T12722 11849-11850 SYM denotes ′
T12723 11851-11852 -LRB- denotes (
T12725 11852-11856 JJ denotes left
T12724 11857-11862 NN denotes panel
T12726 11862-11863 -RRB- denotes )
T12727 11864-11867 CC denotes and
T12728 11868-11869 CD denotes 5
T12729 11869-11870 SYM denotes ′
T12730 11871-11872 -LRB- denotes (
T12732 11872-11877 JJ denotes right
T12731 11878-11883 NN denotes panel
T12733 11883-11884 -RRB- denotes )
T12734 11885-11893 NN denotes flanking
T12720 11894-11901 NNS denotes regions
T12735 11902-11904 IN denotes of
T12736 11905-11908 DT denotes the
T12738 11909-11918 NN denotes insertion
T12737 11919-11929 NN denotes breakpoint
T12739 11929-11930 . denotes .
T12740 11930-11991 sentence denotes Q1 is a cosmid containing the RanBP2 gene up to exon 20 [4].
T12741 11931-11933 NN denotes Q1
T12742 11934-11936 VBZ denotes is
T12743 11937-11938 DT denotes a
T12744 11939-11945 NN denotes cosmid
T12745 11946-11956 VBG denotes containing
T12746 11957-11960 DT denotes the
T12748 11961-11967 NN denotes RanBP2
T12747 11968-11972 NN denotes gene
T12749 11973-11975 IN denotes up
T12750 11976-11978 IN denotes to
T12751 11979-11983 NN denotes exon
T12752 11984-11986 CD denotes 20
T12753 11987-11988 -LRB- denotes [
T12754 11988-11989 CD denotes 4
T12755 11989-11990 -RRB- denotes ]
T12756 11990-11991 . denotes .
T12757 11991-12119 sentence denotes (C) Lateroventral view of a whole-mount stain of a ~12.5 dpc heterozygous embryo for PLAP and β-gal (inset picture) activities.
T12758 11992-11993 -LRB- denotes (
T12759 11993-11994 LS denotes C
T12761 11994-11995 -RRB- denotes )
T12762 11996-12009 JJ denotes Lateroventral
T12760 12010-12014 NN denotes view
T12763 12015-12017 IN denotes of
T12764 12018-12019 DT denotes a
T12766 12020-12025 JJ denotes whole
T12768 12025-12026 HYPH denotes -
T12767 12026-12031 NN denotes mount
T12765 12032-12037 NN denotes stain
T12769 12038-12040 IN denotes of
T12770 12041-12042 DT denotes a
T12772 12043-12044 SYM denotes ~
T12773 12044-12048 CD denotes 12.5
T12774 12049-12052 NN denotes dpc
T12775 12053-12065 JJ denotes heterozygous
T12771 12066-12072 NN denotes embryo
T12776 12073-12076 IN denotes for
T12777 12077-12081 NN denotes PLAP
T12779 12082-12085 CC denotes and
T12780 12086-12087 NN denotes β
T12782 12087-12088 HYPH denotes -
T12781 12088-12091 NN denotes gal
T12783 12092-12093 -LRB- denotes (
T12785 12093-12098 NN denotes inset
T12784 12099-12106 NN denotes picture
T12786 12106-12107 -RRB- denotes )
T12778 12108-12118 NNS denotes activities
T12787 12118-12119 . denotes .
T12788 12119-12286 sentence denotes Although PLAP was broadly expressed (e.g., somites, limbs, and CNS), the PLAP and β-Gal (inset picture) expression was particularly high in the optic vesicle (arrow).
T12789 12120-12128 IN denotes Although
T12791 12129-12133 NN denotes PLAP
T12792 12134-12137 VBD denotes was
T12793 12138-12145 RB denotes broadly
T12790 12146-12155 VBN denotes expressed
T12795 12156-12157 -LRB- denotes (
T12796 12157-12161 FW denotes e.g.
T12798 12161-12163 , denotes ,
T12797 12163-12170 NNS denotes somites
T12799 12170-12172 , denotes ,
T12800 12172-12177 NNS denotes limbs
T12801 12177-12179 , denotes ,
T12802 12179-12182 CC denotes and
T12803 12183-12186 NN denotes CNS
T12804 12186-12187 -RRB- denotes )
T12805 12187-12189 , denotes ,
T12806 12189-12192 DT denotes the
T12808 12193-12197 NN denotes PLAP
T12809 12198-12201 CC denotes and
T12810 12202-12203 NN denotes β
T12812 12203-12204 HYPH denotes -
T12811 12204-12207 NN denotes Gal
T12813 12208-12209 -LRB- denotes (
T12815 12209-12214 NN denotes inset
T12814 12215-12222 NN denotes picture
T12816 12222-12223 -RRB- denotes )
T12807 12224-12234 NN denotes expression
T12794 12235-12238 VBD denotes was
T12817 12239-12251 RB denotes particularly
T12818 12252-12256 JJ denotes high
T12819 12257-12259 IN denotes in
T12820 12260-12263 DT denotes the
T12822 12264-12269 JJ denotes optic
T12821 12270-12277 NN denotes vesicle
T12823 12278-12279 -LRB- denotes (
T12824 12279-12284 NN denotes arrow
T12825 12284-12285 -RRB- denotes )
T12826 12285-12286 . denotes .
T12827 12286-12391 sentence denotes X-gal single (D) and combined staining with PLAP (E) of a retinal section of a 3-mo-old RanBP2+/− mouse.
T12828 12287-12288 NN denotes X
T12830 12288-12289 HYPH denotes -
T12829 12289-12292 NN denotes gal
T12832 12293-12299 JJ denotes single
T12833 12300-12301 -LRB- denotes (
T12834 12301-12302 NN denotes D
T12835 12302-12303 -RRB- denotes )
T12836 12304-12307 CC denotes and
T12837 12308-12316 JJ denotes combined
T12831 12317-12325 NN denotes staining
T12838 12326-12330 IN denotes with
T12839 12331-12335 NN denotes PLAP
T12840 12336-12337 -LRB- denotes (
T12841 12337-12338 NN denotes E
T12842 12338-12339 -RRB- denotes )
T12843 12340-12342 IN denotes of
T12844 12343-12344 DT denotes a
T12846 12345-12352 JJ denotes retinal
T12845 12353-12360 NN denotes section
T12847 12361-12363 IN denotes of
T12848 12364-12365 DT denotes a
T12850 12366-12367 CD denotes 3
T12852 12367-12368 HYPH denotes -
T12851 12368-12370 NN denotes mo
T12854 12370-12371 HYPH denotes -
T12853 12371-12374 JJ denotes old
T12855 12375-12381 NN denotes RanBP2
T12856 12381-12382 SYM denotes +
T12857 12382-12383 HYPH denotes /
T12858 12383-12384 SYM denotes −
T12849 12385-12390 NN denotes mouse
T12859 12390-12391 . denotes .
T12860 12391-12603 sentence denotes Consistent with previous immunocytochemistry studies, β-Gal activity is detected in the neuroretinal bodies and inner segment compartment of photoreceptors with conspicuously strong expression in ganglion cells.
T12861 12392-12402 JJ denotes Consistent
T12863 12403-12407 IN denotes with
T12864 12408-12416 JJ denotes previous
T12866 12417-12436 NN denotes immunocytochemistry
T12865 12437-12444 NNS denotes studies
T12867 12444-12446 , denotes ,
T12868 12446-12447 NN denotes β
T12870 12447-12448 HYPH denotes -
T12869 12448-12451 NN denotes Gal
T12871 12452-12460 NN denotes activity
T12872 12461-12463 VBZ denotes is
T12862 12464-12472 VBN denotes detected
T12873 12473-12475 IN denotes in
T12874 12476-12479 DT denotes the
T12876 12480-12492 JJ denotes neuroretinal
T12875 12493-12499 NNS denotes bodies
T12877 12500-12503 CC denotes and
T12878 12504-12509 JJ denotes inner
T12880 12510-12517 NN denotes segment
T12879 12518-12529 NN denotes compartment
T12881 12530-12532 IN denotes of
T12882 12533-12547 NNS denotes photoreceptors
T12883 12548-12552 IN denotes with
T12884 12553-12566 RB denotes conspicuously
T12885 12567-12573 JJ denotes strong
T12886 12574-12584 NN denotes expression
T12887 12585-12587 IN denotes in
T12888 12588-12596 NN denotes ganglion
T12889 12597-12602 NNS denotes cells
T12890 12602-12603 . denotes .
T12891 12603-12710 sentence denotes PLAP expression is found throughout the plexiform/synaptic layers and outer segment of photoreceptors (E).
T12892 12604-12608 NN denotes PLAP
T12893 12609-12619 NN denotes expression
T12895 12620-12622 VBZ denotes is
T12894 12623-12628 VBN denotes found
T12896 12629-12639 IN denotes throughout
T12897 12640-12643 DT denotes the
T12899 12644-12653 JJ denotes plexiform
T12901 12653-12654 HYPH denotes /
T12900 12654-12662 JJ denotes synaptic
T12898 12663-12669 NNS denotes layers
T12902 12670-12673 CC denotes and
T12903 12674-12679 JJ denotes outer
T12904 12680-12687 NN denotes segment
T12905 12688-12690 IN denotes of
T12906 12691-12705 NNS denotes photoreceptors
T12907 12706-12707 -LRB- denotes (
T12908 12707-12708 NN denotes E
T12909 12708-12709 -RRB- denotes )
T12910 12709-12710 . denotes .
T12911 12710-12975 sentence denotes GC, ganglion cell; PLAP, human placental alkaline phophatase; ROS, rod outer segment; RIS, rod inner segment; ONL, outer nuclear layer; OPL, outer plexiform (synaptic) layer; INL, inner nuclear layer; IPL, inner plexiform (synaptic) layer; GC, ganglion cell layer.
T12912 12711-12713 NN denotes GC
T12913 12713-12715 , denotes ,
T12914 12715-12723 NN denotes ganglion
T12915 12724-12728 NN denotes cell
T12916 12728-12729 : denotes ;
T12917 12730-12734 NN denotes PLAP
T12918 12734-12736 , denotes ,
T12919 12736-12741 JJ denotes human
T12921 12742-12751 JJ denotes placental
T12922 12752-12760 NN denotes alkaline
T12920 12761-12771 NN denotes phophatase
T12923 12771-12772 : denotes ;
T12924 12773-12776 NN denotes ROS
T12925 12776-12778 , denotes ,
T12926 12778-12781 NN denotes rod
T12928 12782-12787 JJ denotes outer
T12927 12788-12795 NN denotes segment
T12929 12795-12796 : denotes ;
T12930 12797-12800 NN denotes RIS
T12931 12800-12802 , denotes ,
T12932 12802-12805 NN denotes rod
T12934 12806-12811 JJ denotes inner
T12933 12812-12819 NN denotes segment
T12935 12819-12820 : denotes ;
T12936 12821-12824 NN denotes ONL
T12937 12824-12826 , denotes ,
T12938 12826-12831 JJ denotes outer
T12940 12832-12839 JJ denotes nuclear
T12939 12840-12845 NN denotes layer
T12941 12845-12846 : denotes ;
T12942 12847-12850 NN denotes OPL
T12943 12850-12852 , denotes ,
T12944 12852-12857 JJ denotes outer
T12946 12858-12867 JJ denotes plexiform
T12947 12868-12869 -LRB- denotes (
T12948 12869-12877 JJ denotes synaptic
T12949 12877-12878 -RRB- denotes )
T12945 12879-12884 NN denotes layer
T12950 12884-12885 : denotes ;
T12951 12886-12889 NN denotes INL
T12952 12889-12891 , denotes ,
T12953 12891-12896 JJ denotes inner
T12955 12897-12904 JJ denotes nuclear
T12954 12905-12910 NN denotes layer
T12956 12910-12911 : denotes ;
T12957 12912-12915 NN denotes IPL
T12958 12915-12917 , denotes ,
T12959 12917-12922 JJ denotes inner
T12961 12923-12932 JJ denotes plexiform
T12962 12933-12934 -LRB- denotes (
T12963 12934-12942 JJ denotes synaptic
T12964 12942-12943 -RRB- denotes )
T12960 12944-12949 NN denotes layer
T12965 12949-12950 : denotes ;
T12966 12951-12953 NN denotes GC
T12967 12953-12955 , denotes ,
T12968 12955-12963 NN denotes ganglion
T12969 12964-12968 NN denotes cell
T12970 12969-12974 NN denotes layer
T12971 12974-12975 . denotes .
T3641 12976-12978 IN denotes In
T3643 12979-12984 NN denotes light
T3644 12985-12987 IN denotes of
T3645 12988-12991 DT denotes the
T3646 12992-13003 NN denotes association
T3647 13004-13006 FW denotes in
T3648 13007-13011 FW denotes vivo
T3649 13012-13014 IN denotes of
T3650 13015-13021 NN denotes RanBP2
T3651 13022-13026 IN denotes with
T3652 13027-13032 NN denotes Cox11
T3653 13033-13036 CC denotes and
T3654 13037-13040 NN denotes HKI
T3655 13041-13042 -LRB- denotes (
T3657 13042-13049 NNS denotes Figures
T3656 13050-13051 CD denotes 1
T3658 13052-13055 CC denotes and
T3659 13056-13057 CD denotes 3
T3660 13057-13058 -RRB- denotes )
T3661 13058-13060 , denotes ,
T3662 13060-13068 JJ denotes profound
T3664 13069-13071 FW denotes in
T3665 13072-13077 FW denotes vitro
T3663 13078-13088 NN denotes modulation
T3666 13089-13091 IN denotes of
T3667 13092-13095 NN denotes HKI
T3668 13096-13105 JJ denotes enzymatic
T3669 13106-13114 NN denotes activity
T3670 13115-13117 IN denotes by
T3671 13118-13124 NN denotes RanBP2
T3672 13125-13128 CC denotes and
T3673 13129-13134 NN denotes Cox11
T3674 13135-13136 -LRB- denotes (
T3675 13136-13142 NN denotes Figure
T3676 13143-13144 CD denotes 2
T3677 13144-13145 -RRB- denotes )
T3678 13145-13147 , denotes ,
T3679 13147-13150 CC denotes and
T3680 13151-13154 DT denotes the
T3682 13155-13163 JJ denotes critical
T3681 13164-13168 NN denotes role
T3683 13169-13171 IN denotes of
T3684 13172-13175 NN denotes HKI
T3685 13176-13178 IN denotes in
T3686 13179-13189 VBG denotes catalyzing
T3687 13190-13191 DT denotes a
T3689 13192-13196 NN denotes rate
T3691 13196-13197 HYPH denotes -
T3690 13197-13205 VBG denotes limiting
T3688 13206-13210 NN denotes step
T3692 13211-13213 IN denotes of
T3693 13214-13224 NN denotes glycolysis
T3694 13224-13226 , denotes ,
T3695 13226-13228 PRP denotes we
T3642 13229-13235 VBD denotes probed
T3696 13236-13243 IN denotes whether
T3698 13244-13250 NN denotes RanBP2
T3700 13250-13251 SYM denotes +
T3701 13251-13252 HYPH denotes /
T3702 13252-13253 SYM denotes −
T3699 13254-13258 NNS denotes mice
T3697 13259-13268 VBD denotes presented
T3703 13269-13281 NNS denotes disturbances
T3704 13282-13284 IN denotes in
T3705 13285-13288 NN denotes HKI
T3706 13288-13290 , denotes ,
T3707 13290-13295 NN denotes Cox11
T3708 13295-13297 , denotes ,
T3709 13297-13300 CC denotes and
T3710 13301-13307 NN denotes energy
T3711 13308-13319 NN denotes homeostasis
T3712 13319-13320 . denotes .
T3713 13320-13649 sentence denotes Monoallelic expression of RanBP2 does not affect the number of NPCs and their distribution in hippocampal neurons (Figure 5A, unpublished data), but it led to consistent lower expression of RanBP2 by more than 50% in the CNS (brain and retina) in 129Ola (Figure 5B–5D), but not in C57BL/6J/129Ola backgrounds (unpublished data).
T3714 13321-13332 JJ denotes Monoallelic
T3715 13333-13343 NN denotes expression
T3717 13344-13346 IN denotes of
T3718 13347-13353 NN denotes RanBP2
T3719 13354-13358 VBZ denotes does
T3720 13359-13362 RB denotes not
T3716 13363-13369 VB denotes affect
T3721 13370-13373 DT denotes the
T3722 13374-13380 NN denotes number
T3723 13381-13383 IN denotes of
T3724 13384-13388 NNS denotes NPCs
T3725 13389-13392 CC denotes and
T3726 13393-13398 PRP$ denotes their
T3727 13399-13411 NN denotes distribution
T3728 13412-13414 IN denotes in
T3729 13415-13426 JJ denotes hippocampal
T3730 13427-13434 NNS denotes neurons
T3731 13435-13436 -LRB- denotes (
T3733 13436-13442 NN denotes Figure
T3734 13443-13445 NN denotes 5A
T3735 13445-13447 , denotes ,
T3736 13447-13458 JJ denotes unpublished
T3732 13459-13463 NNS denotes data
T3737 13463-13464 -RRB- denotes )
T3738 13464-13466 , denotes ,
T3739 13466-13469 CC denotes but
T3740 13470-13472 PRP denotes it
T3741 13473-13476 VBD denotes led
T3742 13477-13479 IN denotes to
T3743 13480-13490 JJ denotes consistent
T3745 13491-13496 JJR denotes lower
T3744 13497-13507 NN denotes expression
T3746 13508-13510 IN denotes of
T3747 13511-13517 NN denotes RanBP2
T3748 13518-13520 IN denotes by
T3749 13521-13525 JJR denotes more
T3751 13526-13530 IN denotes than
T3750 13531-13533 CD denotes 50
T3752 13533-13534 NN denotes %
T3753 13535-13537 IN denotes in
T3754 13538-13541 DT denotes the
T3755 13542-13545 NN denotes CNS
T3756 13546-13547 -LRB- denotes (
T3757 13547-13552 NN denotes brain
T3758 13553-13556 CC denotes and
T3759 13557-13563 NN denotes retina
T3760 13563-13564 -RRB- denotes )
T3761 13565-13567 IN denotes in
T3762 13568-13574 NN denotes 129Ola
T3763 13575-13576 -LRB- denotes (
T3765 13576-13582 NN denotes Figure
T3764 13583-13585 NN denotes 5B
T3766 13585-13586 SYM denotes –
T3767 13586-13588 NN denotes 5D
T3768 13588-13589 -RRB- denotes )
T3769 13589-13591 , denotes ,
T3770 13591-13594 CC denotes but
T3771 13595-13598 RB denotes not
T3772 13599-13601 IN denotes in
T3773 13602-13607 NN denotes C57BL
T3775 13607-13608 HYPH denotes /
T3776 13608-13610 NN denotes 6J
T3777 13610-13611 HYPH denotes /
T3774 13611-13617 NN denotes 129Ola
T3778 13618-13629 NNS denotes backgrounds
T3779 13630-13631 -LRB- denotes (
T3781 13631-13642 JJ denotes unpublished
T3780 13643-13647 NNS denotes data
T3782 13647-13648 -RRB- denotes )
T3783 13648-13649 . denotes .
T3784 13649-13723 sentence denotes Hence, we focused our analysis on the inbred RanBP2+/− 129Ola mouse line.
T3785 13650-13655 RB denotes Hence
T3787 13655-13657 , denotes ,
T3788 13657-13659 PRP denotes we
T3786 13660-13667 VBD denotes focused
T3789 13668-13671 PRP$ denotes our
T3790 13672-13680 NN denotes analysis
T3791 13681-13683 IN denotes on
T3792 13684-13687 DT denotes the
T3794 13688-13694 JJ denotes inbred
T3795 13695-13701 NN denotes RanBP2
T3796 13701-13702 SYM denotes +
T3797 13702-13703 HYPH denotes /
T3798 13703-13704 SYM denotes −
T3799 13705-13711 NN denotes 129Ola
T3800 13712-13717 NN denotes mouse
T3793 13718-13722 NN denotes line
T3801 13722-13723 . denotes .
T3802 13723-13980 sentence denotes Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/−mice by ~50%–60% (Figure 5B and 5C), the levels of others nucleoporins, Nup153 and Nup62, and mHsp70 and Cox11, remained unchanged (Figure 5B, unpublished data).
T3803 13724-13732 IN denotes Although
T3805 13733-13736 DT denotes the
T3806 13737-13743 NNS denotes levels
T3807 13744-13746 IN denotes of
T3808 13747-13753 NN denotes RanBP2
T3809 13754-13758 VBD denotes were
T3804 13759-13768 VBN denotes decreased
T3811 13769-13771 IN denotes in
T3812 13772-13775 DT denotes the
T3813 13776-13782 NN denotes retina
T3814 13782-13784 , denotes ,
T3815 13784-13789 NN denotes brain
T3816 13789-13791 , denotes ,
T3817 13791-13794 CC denotes and
T3818 13795-13806 NN denotes hippocampus
T3819 13807-13809 IN denotes of
T3820 13810-13816 NN denotes RanBP2
T3822 13816-13817 SYM denotes +
T3823 13817-13818 HYPH denotes /
T3824 13818-13819 SYM denotes −
T3821 13819-13823 NNS denotes mice
T3825 13824-13826 IN denotes by
T3826 13827-13828 SYM denotes ~
T3827 13828-13830 CD denotes 50
T3828 13830-13831 NN denotes %
T3829 13831-13832 SYM denotes –
T3831 13832-13834 CD denotes 60
T3830 13834-13835 NN denotes %
T3832 13836-13837 -LRB- denotes (
T3834 13837-13843 NN denotes Figure
T3833 13844-13846 NN denotes 5B
T3835 13847-13850 CC denotes and
T3836 13851-13853 NN denotes 5C
T3837 13853-13854 -RRB- denotes )
T3838 13854-13856 , denotes ,
T3839 13856-13859 DT denotes the
T3840 13860-13866 NNS denotes levels
T3841 13867-13869 IN denotes of
T3842 13870-13876 NNS denotes others
T3843 13877-13889 NNS denotes nucleoporins
T3844 13889-13891 , denotes ,
T3845 13891-13897 NN denotes Nup153
T3846 13898-13901 CC denotes and
T3847 13902-13907 NN denotes Nup62
T3848 13907-13909 , denotes ,
T3849 13909-13912 CC denotes and
T3850 13913-13919 NN denotes mHsp70
T3851 13920-13923 CC denotes and
T3852 13924-13929 NN denotes Cox11
T3853 13929-13931 , denotes ,
T3810 13931-13939 VBD denotes remained
T3854 13940-13949 JJ denotes unchanged
T3855 13950-13951 -LRB- denotes (
T3857 13951-13957 NN denotes Figure
T3858 13958-13960 NN denotes 5B
T3859 13960-13962 , denotes ,
T3860 13962-13973 JJ denotes unpublished
T3856 13974-13978 NNS denotes data
T3861 13978-13979 -RRB- denotes )
T3862 13979-13980 . denotes .
T3863 13980-14079 sentence denotes In addition, we observed a strong decrease of the levels of HKI (3- to 4-fold) (Figure 5B and 5C).
T3864 13981-13983 IN denotes In
T3866 13984-13992 NN denotes addition
T3867 13992-13994 , denotes ,
T3868 13994-13996 PRP denotes we
T3865 13997-14005 VBD denotes observed
T3869 14006-14007 DT denotes a
T3871 14008-14014 JJ denotes strong
T3870 14015-14023 NN denotes decrease
T3872 14024-14026 IN denotes of
T3873 14027-14030 DT denotes the
T3874 14031-14037 NNS denotes levels
T3875 14038-14040 IN denotes of
T3876 14041-14044 NN denotes HKI
T3877 14045-14046 -LRB- denotes (
T3878 14046-14047 CD denotes 3
T3879 14047-14048 HYPH denotes -
T3880 14049-14051 IN denotes to
T3881 14052-14058 RB denotes 4-fold
T3882 14058-14059 -RRB- denotes )
T3883 14060-14061 -LRB- denotes (
T3885 14061-14067 NN denotes Figure
T3884 14068-14070 NN denotes 5B
T3886 14071-14074 CC denotes and
T3887 14075-14077 NN denotes 5C
T3888 14077-14078 -RRB- denotes )
T3889 14078-14079 . denotes .
T3890 14079-14219 sentence denotes This decrease was selective to the CNS, since HKI levels remained largely unaffected in the skeletal muscle, spleen, and liver (Figure 5D).
T3891 14080-14084 DT denotes This
T3892 14085-14093 NN denotes decrease
T3893 14094-14097 VBD denotes was
T3894 14098-14107 JJ denotes selective
T3895 14108-14110 IN denotes to
T3896 14111-14114 DT denotes the
T3897 14115-14118 NN denotes CNS
T3898 14118-14120 , denotes ,
T3899 14120-14125 IN denotes since
T3901 14126-14129 NN denotes HKI
T3902 14130-14136 NNS denotes levels
T3900 14137-14145 VBD denotes remained
T3903 14146-14153 RB denotes largely
T3904 14154-14164 JJ denotes unaffected
T3905 14165-14167 IN denotes in
T3906 14168-14171 DT denotes the
T3908 14172-14180 JJ denotes skeletal
T3907 14181-14187 NN denotes muscle
T3909 14187-14189 , denotes ,
T3910 14189-14195 NN denotes spleen
T3911 14195-14197 , denotes ,
T3912 14197-14200 CC denotes and
T3913 14201-14206 NN denotes liver
T3914 14207-14208 -LRB- denotes (
T3916 14208-14214 NN denotes Figure
T3915 14215-14217 NN denotes 5D
T3917 14217-14218 -RRB- denotes )
T3918 14218-14219 . denotes .
T3919 14219-14442 sentence denotes Because HKI plays a key role in the production of energy intermediate substrates and HKI is virtually the sole HK isoform expressed in the CNS [33,34], we probed the impact of HKI and RanBP2 reduction in the levels of ATP.
T3920 14220-14227 IN denotes Because
T3922 14228-14231 NN denotes HKI
T3921 14232-14237 VBZ denotes plays
T3924 14238-14239 DT denotes a
T3926 14240-14243 JJ denotes key
T3925 14244-14248 NN denotes role
T3927 14249-14251 IN denotes in
T3928 14252-14255 DT denotes the
T3929 14256-14266 NN denotes production
T3930 14267-14269 IN denotes of
T3931 14270-14276 NN denotes energy
T3933 14277-14289 JJ denotes intermediate
T3932 14290-14300 NNS denotes substrates
T3934 14301-14304 CC denotes and
T3935 14305-14308 NN denotes HKI
T3936 14309-14311 VBZ denotes is
T3937 14312-14321 RB denotes virtually
T3939 14322-14325 DT denotes the
T3940 14326-14330 JJ denotes sole
T3941 14331-14333 NN denotes HK
T3938 14334-14341 NN denotes isoform
T3942 14342-14351 VBN denotes expressed
T3943 14352-14354 IN denotes in
T3944 14355-14358 DT denotes the
T3945 14359-14362 NN denotes CNS
T3946 14363-14364 -LRB- denotes [
T3948 14364-14366 CD denotes 33
T3949 14366-14367 , denotes ,
T3947 14367-14369 CD denotes 34
T3950 14369-14370 -RRB- denotes ]
T3951 14370-14372 , denotes ,
T3952 14372-14374 PRP denotes we
T3923 14375-14381 VBD denotes probed
T3953 14382-14385 DT denotes the
T3954 14386-14392 NN denotes impact
T3955 14393-14395 IN denotes of
T3956 14396-14399 NN denotes HKI
T3958 14400-14403 CC denotes and
T3959 14404-14410 NN denotes RanBP2
T3957 14411-14420 NN denotes reduction
T3960 14421-14423 IN denotes in
T3961 14424-14427 DT denotes the
T3962 14428-14434 NNS denotes levels
T3963 14435-14437 IN denotes of
T3964 14438-14441 NN denotes ATP
T3965 14441-14442 . denotes .
T3966 14442-14593 sentence denotes As shown in Figure 5E, there was significant and concordant reduction in levels of ATP in the CNS (brain and retina), but not in non-neuronal tissues.
T3967 14443-14445 IN denotes As
T3968 14446-14451 VBN denotes shown
T3970 14452-14454 IN denotes in
T3971 14455-14461 NN denotes Figure
T3972 14462-14464 NN denotes 5E
T3973 14464-14466 , denotes ,
T3974 14466-14471 EX denotes there
T3969 14472-14475 VBD denotes was
T3975 14476-14487 JJ denotes significant
T3977 14488-14491 CC denotes and
T3978 14492-14502 JJ denotes concordant
T3976 14503-14512 NN denotes reduction
T3979 14513-14515 IN denotes in
T3980 14516-14522 NNS denotes levels
T3981 14523-14525 IN denotes of
T3982 14526-14529 NN denotes ATP
T3983 14530-14532 IN denotes in
T3984 14533-14536 DT denotes the
T3985 14537-14540 NN denotes CNS
T3986 14541-14542 -LRB- denotes (
T3987 14542-14547 NN denotes brain
T3988 14548-14551 CC denotes and
T3989 14552-14558 NN denotes retina
T3990 14558-14559 -RRB- denotes )
T3991 14559-14561 , denotes ,
T3992 14561-14564 CC denotes but
T3993 14565-14568 RB denotes not
T3994 14569-14571 IN denotes in
T3995 14572-14584 JJ denotes non-neuronal
T3996 14585-14592 NNS denotes tissues
T3997 14592-14593 . denotes .
T3998 14593-14813 sentence denotes Finally, we also observed partial and selective delocalization of HKI, but not of Cox11, from the ellipsoid (mitochondria-rich) to the adjacent myoid subcellular compartment of rod photosensory neurons (Figure S2A–S2E).
T3999 14594-14601 RB denotes Finally
T4001 14601-14603 , denotes ,
T4002 14603-14605 PRP denotes we
T4003 14606-14610 RB denotes also
T4000 14611-14619 VBD denotes observed
T4004 14620-14627 JJ denotes partial
T4006 14628-14631 CC denotes and
T4007 14632-14641 JJ denotes selective
T4005 14642-14656 NN denotes delocalization
T4008 14657-14659 IN denotes of
T4009 14660-14663 NN denotes HKI
T4010 14663-14665 , denotes ,
T4011 14665-14668 CC denotes but
T4012 14669-14672 RB denotes not
T4013 14673-14675 IN denotes of
T4014 14676-14681 NN denotes Cox11
T4015 14681-14683 , denotes ,
T4016 14683-14687 IN denotes from
T4017 14688-14691 DT denotes the
T4018 14692-14701 JJ denotes ellipsoid
T4019 14702-14703 -LRB- denotes (
T4020 14703-14715 NNS denotes mitochondria
T4022 14715-14716 HYPH denotes -
T4021 14716-14720 JJ denotes rich
T4023 14720-14721 -RRB- denotes )
T4024 14722-14724 IN denotes to
T4025 14725-14728 DT denotes the
T4027 14729-14737 JJ denotes adjacent
T4026 14738-14743 JJ denotes myoid
T4028 14744-14755 JJ denotes subcellular
T4029 14756-14767 NN denotes compartment
T4030 14768-14770 IN denotes of
T4031 14771-14774 NN denotes rod
T4033 14775-14787 JJ denotes photosensory
T4032 14788-14795 NNS denotes neurons
T4034 14796-14797 -LRB- denotes (
T4036 14797-14803 NN denotes Figure
T4035 14804-14807 NN denotes S2A
T4037 14807-14808 SYM denotes –
T4038 14808-14811 NN denotes S2E
T4039 14811-14812 -RRB- denotes )
T4040 14812-14813 . denotes .
T4041 14813-14954 sentence denotes This was also accompanied by reduced HKI levels in the inner retina, in particular in the inner plexiform (synaptic) layer (Figure S2A–S2E).
T4042 14814-14818 DT denotes This
T4044 14819-14822 VBD denotes was
T4045 14823-14827 RB denotes also
T4043 14828-14839 VBN denotes accompanied
T4046 14840-14842 IN denotes by
T4047 14843-14850 VBN denotes reduced
T4049 14851-14854 NN denotes HKI
T4048 14855-14861 NNS denotes levels
T4050 14862-14864 IN denotes in
T4051 14865-14868 DT denotes the
T4053 14869-14874 JJ denotes inner
T4052 14875-14881 NN denotes retina
T4054 14881-14883 , denotes ,
T4055 14883-14885 IN denotes in
T4057 14886-14896 JJ denotes particular
T4056 14897-14899 IN denotes in
T4058 14900-14903 DT denotes the
T4060 14904-14909 JJ denotes inner
T4061 14910-14919 JJ denotes plexiform
T4062 14920-14921 -LRB- denotes (
T4063 14921-14929 JJ denotes synaptic
T4064 14929-14930 -RRB- denotes )
T4059 14931-14936 NN denotes layer
T4065 14937-14938 -LRB- denotes (
T4067 14938-14944 NN denotes Figure
T4066 14945-14948 NN denotes S2A
T4068 14948-14949 SYM denotes –
T4069 14949-14952 NN denotes S2E
T4070 14952-14953 -RRB- denotes )
T4071 14953-14954 . denotes .
T13139 14965-14983 NN denotes Haploinsufficiency
T13141 14984-14986 IN denotes of
T13142 14987-14993 NN denotes RanBP2
T13140 14994-15000 VBZ denotes Causes
T13143 15001-15002 DT denotes a
T13144 15003-15011 NN denotes Decrease
T13145 15012-15014 IN denotes in
T13146 15015-15018 NN denotes HKI
T13147 15019-15026 NN denotes Protein
T13148 15027-15030 CC denotes and
T13149 15031-15034 NN denotes ATP
T13150 15035-15041 NNS denotes Levels
T13151 15041-15190 sentence denotes (A) Quantitative analysis of NPCs in dissociated hippocampal neurons of wild-type (+/+) and heterozygote (+/−) mice upon immunostaining with mAb414.
T13152 15042-15043 -LRB- denotes (
T13153 15043-15044 LS denotes A
T13155 15044-15045 -RRB- denotes )
T13156 15046-15058 JJ denotes Quantitative
T13154 15059-15067 NN denotes analysis
T13157 15068-15070 IN denotes of
T13158 15071-15075 NNS denotes NPCs
T13159 15076-15078 IN denotes in
T13160 15079-15090 VBN denotes dissociated
T13162 15091-15102 JJ denotes hippocampal
T13161 15103-15110 NNS denotes neurons
T13163 15111-15113 IN denotes of
T13164 15114-15118 JJ denotes wild
T13166 15118-15119 HYPH denotes -
T13165 15119-15123 NN denotes type
T13168 15124-15125 -LRB- denotes (
T13170 15125-15126 SYM denotes +
T13171 15126-15127 HYPH denotes /
T13169 15127-15128 SYM denotes +
T13172 15128-15129 -RRB- denotes )
T13173 15130-15133 CC denotes and
T13174 15134-15146 NN denotes heterozygote
T13175 15147-15148 -LRB- denotes (
T13177 15148-15149 SYM denotes +
T13178 15149-15150 HYPH denotes /
T13176 15150-15151 SYM denotes −
T13179 15151-15152 -RRB- denotes )
T13167 15153-15157 NNS denotes mice
T13180 15158-15162 IN denotes upon
T13181 15163-15177 NN denotes immunostaining
T13182 15178-15182 IN denotes with
T13183 15183-15189 NN denotes mAb414
T13184 15189-15190 . denotes .
T13185 15190-15313 sentence denotes No difference in the density of NPCs (3–4 NPC/μm2) at the nuclear envelope was found between RanBP2+/+ and RanBP2+/− mice.
T13186 15191-15193 DT denotes No
T13187 15194-15204 NN denotes difference
T13189 15205-15207 IN denotes in
T13190 15208-15211 DT denotes the
T13191 15212-15219 NN denotes density
T13192 15220-15222 IN denotes of
T13193 15223-15227 NNS denotes NPCs
T13194 15228-15229 -LRB- denotes (
T13195 15229-15230 CD denotes 3
T13197 15230-15231 SYM denotes –
T13196 15231-15232 CD denotes 4
T13198 15233-15236 NN denotes NPC
T13199 15236-15237 SYM denotes /
T13200 15237-15240 NN denotes μm2
T13201 15240-15241 -RRB- denotes )
T13202 15242-15244 IN denotes at
T13203 15245-15248 DT denotes the
T13205 15249-15256 JJ denotes nuclear
T13204 15257-15265 NN denotes envelope
T13206 15266-15269 VBD denotes was
T13188 15270-15275 VBN denotes found
T13207 15276-15283 IN denotes between
T13208 15284-15290 NN denotes RanBP2
T13210 15290-15291 SYM denotes +
T13211 15291-15292 HYPH denotes /
T13212 15292-15293 SYM denotes +
T13213 15294-15297 CC denotes and
T13214 15298-15304 NN denotes RanBP2
T13215 15304-15305 SYM denotes +
T13216 15305-15306 HYPH denotes /
T13217 15306-15307 SYM denotes −
T13209 15308-15312 NNS denotes mice
T13218 15312-15313 . denotes .
T13219 15313-15478 sentence denotes (B) Immunoblots with anti-RanBP2/Nup153/Nup62 (mAb414), −HKI, −mHsp70, and −Cox11 antibodies of retinal (top panel) and hippocampal homogenates of +/+ and +/− mice.
T13220 15314-15315 -LRB- denotes (
T13221 15315-15316 LS denotes B
T13223 15316-15317 -RRB- denotes )
T13222 15318-15329 NNS denotes Immunoblots
T13224 15330-15334 IN denotes with
T13225 15335-15346 NN denotes anti-RanBP2
T13227 15346-15347 HYPH denotes /
T13228 15347-15353 NN denotes Nup153
T13229 15353-15354 HYPH denotes /
T13226 15354-15359 NN denotes Nup62
T13231 15360-15361 -LRB- denotes (
T13232 15361-15367 NN denotes mAb414
T13233 15367-15368 -RRB- denotes )
T13234 15368-15370 , denotes ,
T13235 15370-15371 SYM denotes −
T13236 15371-15374 NN denotes HKI
T13237 15374-15376 , denotes ,
T13238 15376-15377 SYM denotes −
T13239 15377-15383 NN denotes mHsp70
T13240 15383-15385 , denotes ,
T13241 15385-15388 CC denotes and
T13242 15389-15390 SYM denotes −
T13243 15390-15395 NN denotes Cox11
T13230 15396-15406 NNS denotes antibodies
T13244 15407-15409 IN denotes of
T13245 15410-15417 JJ denotes retinal
T13247 15418-15419 -LRB- denotes (
T13249 15419-15422 JJ denotes top
T13248 15423-15428 NN denotes panel
T13250 15428-15429 -RRB- denotes )
T13251 15430-15433 CC denotes and
T13252 15434-15445 JJ denotes hippocampal
T13246 15446-15457 NNS denotes homogenates
T13253 15458-15460 IN denotes of
T13254 15461-15462 SYM denotes +
T13256 15462-15463 HYPH denotes /
T13255 15463-15464 SYM denotes +
T13258 15465-15468 CC denotes and
T13259 15469-15470 SYM denotes +
T13261 15470-15471 HYPH denotes /
T13260 15471-15472 SYM denotes −
T13257 15473-15477 NNS denotes mice
T13262 15477-15478 . denotes .
T13263 15478-15611 sentence denotes In comparison to RanBP2+/+, RanBP2+/− mice exhibit a reduction in the expression levels of RanBP2 and HKI but not of other proteins.
T13264 15479-15481 IN denotes In
T13266 15482-15492 NN denotes comparison
T13267 15493-15495 IN denotes to
T13268 15496-15502 NN denotes RanBP2
T13269 15502-15503 SYM denotes +
T13270 15503-15504 HYPH denotes /
T13271 15504-15505 SYM denotes +
T13272 15505-15507 , denotes ,
T13273 15507-15513 NN denotes RanBP2
T13275 15513-15514 SYM denotes +
T13276 15514-15515 HYPH denotes /
T13277 15515-15516 SYM denotes −
T13274 15517-15521 NNS denotes mice
T13265 15522-15529 VBP denotes exhibit
T13278 15530-15531 DT denotes a
T13279 15532-15541 NN denotes reduction
T13280 15542-15544 IN denotes in
T13281 15545-15548 DT denotes the
T13283 15549-15559 NN denotes expression
T13282 15560-15566 NNS denotes levels
T13284 15567-15569 IN denotes of
T13285 15570-15576 NN denotes RanBP2
T13286 15577-15580 CC denotes and
T13287 15581-15584 NN denotes HKI
T13288 15585-15588 CC denotes but
T13289 15589-15592 RB denotes not
T13290 15593-15595 IN denotes of
T13291 15596-15601 JJ denotes other
T13292 15602-15610 NN denotes proteins
T13293 15610-15611 . denotes .
T13294 15611-15760 sentence denotes (C) Quantitative analysis of relative protein expression levels of RanBP2, Cox11, HKI, and mHsp70 in the hippocampus of RanBP2+/+ and RanBP2+/−mice.
T13295 15612-15613 -LRB- denotes (
T13296 15613-15614 LS denotes C
T13298 15614-15615 -RRB- denotes )
T13299 15616-15628 JJ denotes Quantitative
T13297 15629-15637 NN denotes analysis
T13300 15638-15640 IN denotes of
T13301 15641-15649 JJ denotes relative
T13303 15650-15657 NN denotes protein
T13304 15658-15668 NN denotes expression
T13302 15669-15675 NNS denotes levels
T13305 15676-15678 IN denotes of
T13306 15679-15685 NN denotes RanBP2
T13307 15685-15687 , denotes ,
T13308 15687-15692 NN denotes Cox11
T13309 15692-15694 , denotes ,
T13310 15694-15697 NN denotes HKI
T13311 15697-15699 , denotes ,
T13312 15699-15702 CC denotes and
T13313 15703-15709 NN denotes mHsp70
T13314 15710-15712 IN denotes in
T13315 15713-15716 DT denotes the
T13316 15717-15728 NN denotes hippocampus
T13317 15729-15731 IN denotes of
T13318 15732-15738 NN denotes RanBP2
T13320 15738-15739 SYM denotes +
T13321 15739-15740 HYPH denotes /
T13322 15740-15741 SYM denotes +
T13323 15742-15745 CC denotes and
T13324 15746-15752 NN denotes RanBP2
T13325 15752-15753 SYM denotes +
T13326 15753-15754 HYPH denotes /
T13327 15754-15755 SYM denotes −
T13319 15755-15759 NNS denotes mice
T13328 15759-15760 . denotes .
T13329 15760-15834 sentence denotes There is ~2- and 4-fold reduction of RanBP2 and HKI in heterozygote mice.
T13330 15761-15766 EX denotes There
T13331 15767-15769 VBZ denotes is
T13332 15770-15771 SYM denotes ~
T13333 15771-15772 CD denotes 2
T13335 15772-15773 HYPH denotes -
T13336 15774-15777 CC denotes and
T13337 15778-15784 RB denotes 4-fold
T13334 15785-15794 NN denotes reduction
T13338 15795-15797 IN denotes of
T13339 15798-15804 NN denotes RanBP2
T13340 15805-15808 CC denotes and
T13341 15809-15812 NN denotes HKI
T13342 15813-15815 IN denotes in
T13343 15816-15828 NN denotes heterozygote
T13344 15829-15833 NNS denotes mice
T13345 15833-15834 . denotes .
T13346 15834-15953 sentence denotes (D) The level of HKI is reduced in the brain but not in other non-neuronal tissues tested (muscle, spleen, and liver).
T13347 15835-15836 -LRB- denotes (
T13348 15836-15837 LS denotes D
T13350 15837-15838 -RRB- denotes )
T13351 15839-15842 DT denotes The
T13352 15843-15848 NN denotes level
T13353 15849-15851 IN denotes of
T13354 15852-15855 NN denotes HKI
T13355 15856-15858 VBZ denotes is
T13349 15859-15866 VBN denotes reduced
T13356 15867-15869 IN denotes in
T13357 15870-15873 DT denotes the
T13358 15874-15879 NN denotes brain
T13359 15880-15883 CC denotes but
T13360 15884-15887 RB denotes not
T13361 15888-15890 IN denotes in
T13362 15891-15896 JJ denotes other
T13364 15897-15909 JJ denotes non-neuronal
T13363 15910-15917 NNS denotes tissues
T13365 15918-15924 VBN denotes tested
T13366 15925-15926 -LRB- denotes (
T13367 15926-15932 NN denotes muscle
T13368 15932-15934 , denotes ,
T13369 15934-15940 NN denotes spleen
T13370 15940-15942 , denotes ,
T13371 15942-15945 CC denotes and
T13372 15946-15951 NN denotes liver
T13373 15951-15952 -RRB- denotes )
T13374 15952-15953 . denotes .
T13375 15953-16081 sentence denotes (E) The total ATP level is reduced in the CNS tissues (brain and retina) but not in non-neuronal tissues tested (e.g., spleen).
T13376 15954-15955 -LRB- denotes (
T13377 15955-15956 LS denotes E
T13379 15956-15957 -RRB- denotes )
T13380 15958-15961 DT denotes The
T13382 15962-15967 JJ denotes total
T13383 15968-15971 NN denotes ATP
T13381 15972-15977 NN denotes level
T13384 15978-15980 VBZ denotes is
T13378 15981-15988 VBN denotes reduced
T13385 15989-15991 IN denotes in
T13386 15992-15995 DT denotes the
T13388 15996-15999 NN denotes CNS
T13387 16000-16007 NNS denotes tissues
T13389 16008-16009 -LRB- denotes (
T13390 16009-16014 NN denotes brain
T13391 16015-16018 CC denotes and
T13392 16019-16025 NN denotes retina
T13393 16025-16026 -RRB- denotes )
T13394 16027-16030 CC denotes but
T13395 16031-16034 RB denotes not
T13396 16035-16037 IN denotes in
T13397 16038-16050 JJ denotes non-neuronal
T13398 16051-16058 NNS denotes tissues
T13399 16059-16065 VBN denotes tested
T13400 16066-16067 -LRB- denotes (
T13401 16067-16071 FW denotes e.g.
T13403 16071-16073 , denotes ,
T13402 16073-16079 NN denotes spleen
T13404 16079-16080 -RRB- denotes )
T13405 16080-16081 . denotes .
T4308 16083-16092 JJ denotes Metabolic
T4309 16093-16105 NNS denotes Disturbances
T4310 16106-16112 VBN denotes Caused
T4311 16113-16115 IN denotes by
T4312 16116-16134 NN denotes Haploinsufficiency
T4313 16135-16137 IN denotes of
T4314 16138-16144 NN denotes RanBP2
T4315 16144-16273 sentence denotes The growth rates of inbred RanBP2+/− mice on high-fat (~10% fat) diet were significantly slower than RanBP2+/+ mice (Figure 6A).
T4316 16145-16148 DT denotes The
T4318 16149-16155 NN denotes growth
T4317 16156-16161 NNS denotes rates
T4320 16162-16164 IN denotes of
T4321 16165-16171 JJ denotes inbred
T4323 16172-16178 NN denotes RanBP2
T4324 16178-16179 SYM denotes +
T4325 16179-16180 HYPH denotes /
T4326 16180-16181 SYM denotes −
T4322 16182-16186 NNS denotes mice
T4327 16187-16189 IN denotes on
T4328 16190-16194 JJ denotes high
T4330 16194-16195 HYPH denotes -
T4329 16195-16198 NN denotes fat
T4332 16199-16200 -LRB- denotes (
T4333 16200-16201 SYM denotes ~
T4334 16201-16203 CD denotes 10
T4335 16203-16204 NN denotes %
T4336 16205-16208 NN denotes fat
T4337 16208-16209 -RRB- denotes )
T4331 16210-16214 NN denotes diet
T4319 16215-16219 VBD denotes were
T4338 16220-16233 RB denotes significantly
T4339 16234-16240 JJR denotes slower
T4340 16241-16245 IN denotes than
T4341 16246-16252 NN denotes RanBP2
T4343 16252-16253 SYM denotes +
T4344 16253-16254 HYPH denotes /
T4345 16254-16255 SYM denotes +
T4342 16256-16260 NNS denotes mice
T4346 16261-16262 -LRB- denotes (
T4348 16262-16268 NN denotes Figure
T4347 16269-16271 NN denotes 6A
T4349 16271-16272 -RRB- denotes )
T4350 16272-16273 . denotes .
T4351 16273-16401 sentence denotes Beginning at around 4 mo of age, RanBP2+/− mice exhibit a significant slower gain in body mass than wild-type mice (Figure 6A).
T4352 16274-16283 VBG denotes Beginning
T4354 16284-16286 IN denotes at
T4355 16287-16293 IN denotes around
T4356 16294-16295 CD denotes 4
T4357 16296-16298 NNS denotes mo
T4358 16299-16301 IN denotes of
T4359 16302-16305 NN denotes age
T4360 16305-16307 , denotes ,
T4361 16307-16313 NN denotes RanBP2
T4363 16313-16314 SYM denotes +
T4364 16314-16315 HYPH denotes /
T4365 16315-16316 SYM denotes −
T4362 16317-16321 NNS denotes mice
T4353 16322-16329 VBP denotes exhibit
T4366 16330-16331 DT denotes a
T4368 16332-16343 JJ denotes significant
T4369 16344-16350 JJR denotes slower
T4367 16351-16355 NN denotes gain
T4370 16356-16358 IN denotes in
T4371 16359-16363 NN denotes body
T4372 16364-16368 NN denotes mass
T4373 16369-16373 IN denotes than
T4374 16374-16378 JJ denotes wild
T4376 16378-16379 HYPH denotes -
T4375 16379-16383 NN denotes type
T4377 16384-16388 NNS denotes mice
T4378 16389-16390 -LRB- denotes (
T4380 16390-16396 NN denotes Figure
T4379 16397-16399 NN denotes 6A
T4381 16399-16400 -RRB- denotes )
T4382 16400-16401 . denotes .
T4383 16401-16560 sentence denotes In addition, RanBP2+/− inbred mice presented deficits in body mass that were erased by changing the genetic background to a mixed C57BL/6J/129Ola (Figure 6B).
T4384 16402-16404 IN denotes In
T4386 16405-16413 NN denotes addition
T4387 16413-16415 , denotes ,
T4388 16415-16421 NN denotes RanBP2
T4390 16421-16422 SYM denotes +
T4391 16422-16423 HYPH denotes /
T4392 16423-16424 SYM denotes −
T4393 16425-16431 JJ denotes inbred
T4389 16432-16436 NNS denotes mice
T4385 16437-16446 VBD denotes presented
T4394 16447-16455 NNS denotes deficits
T4395 16456-16458 IN denotes in
T4396 16459-16463 NN denotes body
T4397 16464-16468 NN denotes mass
T4398 16469-16473 WDT denotes that
T4400 16474-16478 VBD denotes were
T4399 16479-16485 VBN denotes erased
T4401 16486-16488 IN denotes by
T4402 16489-16497 VBG denotes changing
T4403 16498-16501 DT denotes the
T4405 16502-16509 JJ denotes genetic
T4404 16510-16520 NN denotes background
T4406 16521-16523 IN denotes to
T4407 16524-16525 DT denotes a
T4409 16526-16531 JJ denotes mixed
T4410 16532-16537 NN denotes C57BL
T4411 16537-16538 HYPH denotes /
T4412 16538-16540 NN denotes 6J
T4413 16540-16541 HYPH denotes /
T4408 16541-16547 NN denotes 129Ola
T4414 16548-16549 -LRB- denotes (
T4416 16549-16555 NN denotes Figure
T4415 16556-16558 NN denotes 6B
T4417 16558-16559 -RRB- denotes )
T4418 16559-16560 . denotes .
T4419 16560-16647 sentence denotes Food consumption did not account for the body weight differences observed (Figure 6C).
T4420 16561-16565 NN denotes Food
T4421 16566-16577 NN denotes consumption
T4423 16578-16581 VBD denotes did
T4424 16582-16585 RB denotes not
T4422 16586-16593 VB denotes account
T4425 16594-16597 IN denotes for
T4426 16598-16601 DT denotes the
T4428 16602-16606 NN denotes body
T4429 16607-16613 NN denotes weight
T4427 16614-16625 NNS denotes differences
T4430 16626-16634 VBN denotes observed
T4431 16635-16636 -LRB- denotes (
T4433 16636-16642 NN denotes Figure
T4432 16643-16645 NN denotes 6C
T4434 16645-16646 -RRB- denotes )
T4435 16646-16647 . denotes .
T4436 16647-17503 sentence denotes Figure 6 RanBP2+/− Mice on High-Fat Diet Exhibit Deficits in Growth (A) In comparison to wild-type mice, RanBP2+/− mice show slower growth rates beginning at 4 mo of age (arrow), and the difference in body weight between these is maintained afterward. Note that RanBP2+/− mice lack the growth spur observed in wild-type mice between 3 and 4 mo of age. (B) In comparison to inbred RanBP2+/−mice (129Ola genetic background), the difference in body weight between RanBP2+/+ and RanBP2+/− mice is masked upon placing these on a mixed 129Ola/C57Bl6 genetic background. (C) RanBP2+/+ and RanBP2+/−inbred mice exhibit similar rates of food consumption. Mice in (A), (B), and (C) were placed on a high-fat diet since birth (n = 5). HKI in the CNS (brain and retina) accounts virtually for all expression of HK isozymes and glucose utilization in the CNS [33,34].
T13498 16658-16664 NN denotes RanBP2
T13500 16664-16665 SYM denotes +
T13501 16665-16666 HYPH denotes /
T13502 16666-16667 SYM denotes −
T13499 16668-16672 NNS denotes Mice
T13504 16673-16675 IN denotes on
T13505 16676-16680 JJ denotes High
T13507 16680-16681 HYPH denotes -
T13506 16681-16684 NN denotes Fat
T13508 16685-16689 NN denotes Diet
T13503 16690-16697 VBP denotes Exhibit
T13509 16698-16706 NNS denotes Deficits
T13510 16707-16709 IN denotes in
T13511 16710-16716 NN denotes Growth
T13512 16716-16900 sentence denotes (A) In comparison to wild-type mice, RanBP2+/− mice show slower growth rates beginning at 4 mo of age (arrow), and the difference in body weight between these is maintained afterward.
T13513 16717-16718 -LRB- denotes (
T13514 16718-16719 LS denotes A
T13516 16719-16720 -RRB- denotes )
T13517 16721-16723 IN denotes In
T13518 16724-16734 NN denotes comparison
T13519 16735-16737 IN denotes to
T13520 16738-16742 JJ denotes wild
T13522 16742-16743 HYPH denotes -
T13521 16743-16747 NN denotes type
T13523 16748-16752 NNS denotes mice
T13524 16752-16754 , denotes ,
T13525 16754-16760 NN denotes RanBP2
T13527 16760-16761 SYM denotes +
T13528 16761-16762 HYPH denotes /
T13529 16762-16763 SYM denotes −
T13526 16764-16768 NNS denotes mice
T13515 16769-16773 VBP denotes show
T13530 16774-16780 JJR denotes slower
T13532 16781-16787 NN denotes growth
T13531 16788-16793 NNS denotes rates
T13533 16794-16803 VBG denotes beginning
T13534 16804-16806 IN denotes at
T13535 16807-16808 CD denotes 4
T13536 16809-16811 NNS denotes mo
T13537 16812-16814 IN denotes of
T13538 16815-16818 NN denotes age
T13539 16819-16820 -LRB- denotes (
T13540 16820-16825 NN denotes arrow
T13541 16825-16826 -RRB- denotes )
T13542 16826-16828 , denotes ,
T13543 16828-16831 CC denotes and
T13544 16832-16835 DT denotes the
T13545 16836-16846 NN denotes difference
T13547 16847-16849 IN denotes in
T13548 16850-16854 NN denotes body
T13549 16855-16861 NN denotes weight
T13550 16862-16869 IN denotes between
T13551 16870-16875 DT denotes these
T13552 16876-16878 VBZ denotes is
T13546 16879-16889 VBN denotes maintained
T13553 16890-16899 RB denotes afterward
T13554 16899-16900 . denotes .
T13555 16900-17000 sentence denotes Note that RanBP2+/− mice lack the growth spur observed in wild-type mice between 3 and 4 mo of age.
T13556 16901-16905 VB denotes Note
T13557 16906-16910 IN denotes that
T13559 16911-16917 NN denotes RanBP2
T13561 16917-16918 SYM denotes +
T13562 16918-16919 HYPH denotes /
T13563 16919-16920 SYM denotes −
T13560 16921-16925 NNS denotes mice
T13558 16926-16930 VBP denotes lack
T13564 16931-16934 DT denotes the
T13566 16935-16941 NN denotes growth
T13565 16942-16946 NN denotes spur
T13567 16947-16955 VBN denotes observed
T13568 16956-16958 IN denotes in
T13569 16959-16963 JJ denotes wild
T13571 16963-16964 HYPH denotes -
T13570 16964-16968 NN denotes type
T13572 16969-16973 NNS denotes mice
T13573 16974-16981 IN denotes between
T13574 16982-16983 CD denotes 3
T13576 16984-16987 CC denotes and
T13577 16988-16989 CD denotes 4
T13575 16990-16992 NNS denotes mo
T13578 16993-16995 IN denotes of
T13579 16996-16999 NN denotes age
T13580 16999-17000 . denotes .
T13581 17000-17212 sentence denotes (B) In comparison to inbred RanBP2+/−mice (129Ola genetic background), the difference in body weight between RanBP2+/+ and RanBP2+/− mice is masked upon placing these on a mixed 129Ola/C57Bl6 genetic background.
T13582 17001-17002 -LRB- denotes (
T13583 17002-17003 LS denotes B
T13585 17003-17004 -RRB- denotes )
T13586 17005-17007 IN denotes In
T13587 17008-17018 NN denotes comparison
T13588 17019-17021 IN denotes to
T13589 17022-17028 JJ denotes inbred
T13591 17029-17035 NN denotes RanBP2
T13592 17035-17036 SYM denotes +
T13593 17036-17037 HYPH denotes /
T13594 17037-17038 SYM denotes −
T13590 17038-17042 NNS denotes mice
T13595 17043-17044 -LRB- denotes (
T13596 17044-17050 NN denotes 129Ola
T13598 17051-17058 JJ denotes genetic
T13597 17059-17069 NN denotes background
T13599 17069-17070 -RRB- denotes )
T13600 17070-17072 , denotes ,
T13601 17072-17075 DT denotes the
T13602 17076-17086 NN denotes difference
T13603 17087-17089 IN denotes in
T13604 17090-17094 NN denotes body
T13605 17095-17101 NN denotes weight
T13606 17102-17109 IN denotes between
T13607 17110-17116 NN denotes RanBP2
T13609 17116-17117 SYM denotes +
T13610 17117-17118 HYPH denotes /
T13611 17118-17119 SYM denotes +
T13612 17120-17123 CC denotes and
T13613 17124-17130 NN denotes RanBP2
T13614 17130-17131 SYM denotes +
T13615 17131-17132 HYPH denotes /
T13616 17132-17133 SYM denotes −
T13608 17134-17138 NNS denotes mice
T13617 17139-17141 VBZ denotes is
T13584 17142-17148 VBN denotes masked
T13618 17149-17153 IN denotes upon
T13619 17154-17161 VBG denotes placing
T13620 17162-17167 DT denotes these
T13621 17168-17170 IN denotes on
T13622 17171-17172 DT denotes a
T13624 17173-17178 JJ denotes mixed
T13625 17179-17185 NN denotes 129Ola
T13627 17185-17186 HYPH denotes /
T13626 17186-17192 NN denotes C57Bl6
T13628 17193-17200 JJ denotes genetic
T13623 17201-17211 NN denotes background
T13629 17211-17212 . denotes .
T13630 17212-17294 sentence denotes (C) RanBP2+/+ and RanBP2+/−inbred mice exhibit similar rates of food consumption.
T13631 17213-17214 -LRB- denotes (
T13632 17214-17215 LS denotes C
T13634 17215-17216 -RRB- denotes )
T13635 17217-17223 NN denotes RanBP2
T13637 17223-17224 SYM denotes +
T13638 17224-17225 HYPH denotes /
T13639 17225-17226 SYM denotes +
T13640 17227-17230 CC denotes and
T13641 17231-17237 NN denotes RanBP2
T13642 17237-17238 SYM denotes +
T13643 17238-17239 HYPH denotes /
T13644 17239-17240 SYM denotes −
T13645 17240-17246 JJ denotes inbred
T13636 17247-17251 NNS denotes mice
T13633 17252-17259 VBP denotes exhibit
T13646 17260-17267 JJ denotes similar
T13647 17268-17273 NNS denotes rates
T13648 17274-17276 IN denotes of
T13649 17277-17281 NN denotes food
T13650 17282-17293 NN denotes consumption
T13651 17293-17294 . denotes .
T13652 17294-17372 sentence denotes Mice in (A), (B), and (C) were placed on a high-fat diet since birth (n = 5).
T13653 17295-17299 NNS denotes Mice
T13655 17300-17302 IN denotes in
T13656 17303-17304 -LRB- denotes (
T13657 17304-17305 NN denotes A
T13658 17305-17306 -RRB- denotes )
T13659 17306-17308 , denotes ,
T13660 17308-17309 -LRB- denotes (
T13661 17309-17310 NN denotes B
T13662 17310-17311 -RRB- denotes )
T13663 17311-17313 , denotes ,
T13664 17313-17316 CC denotes and
T13665 17317-17318 -LRB- denotes (
T13666 17318-17319 NN denotes C
T13667 17319-17320 -RRB- denotes )
T13668 17321-17325 VBD denotes were
T13654 17326-17332 VBN denotes placed
T13669 17333-17335 IN denotes on
T13670 17336-17337 DT denotes a
T13672 17338-17342 JJ denotes high
T13674 17342-17343 HYPH denotes -
T13673 17343-17346 NN denotes fat
T13671 17347-17351 NN denotes diet
T13675 17352-17357 IN denotes since
T13676 17358-17363 NN denotes birth
T13677 17364-17365 -LRB- denotes (
T13679 17365-17366 NN denotes n
T13680 17367-17368 SYM denotes =
T13678 17369-17370 CD denotes 5
T13681 17370-17371 -RRB- denotes )
T13682 17371-17372 . denotes .
T4437 17373-17376 NN denotes HKI
T4439 17377-17379 IN denotes in
T4440 17380-17383 DT denotes the
T4441 17384-17387 NN denotes CNS
T4442 17388-17389 -LRB- denotes (
T4443 17389-17394 NN denotes brain
T4444 17395-17398 CC denotes and
T4445 17399-17405 NN denotes retina
T4446 17405-17406 -RRB- denotes )
T4438 17407-17415 VBZ denotes accounts
T4447 17416-17425 RB denotes virtually
T4448 17426-17429 IN denotes for
T4449 17430-17433 DT denotes all
T4450 17434-17444 NN denotes expression
T4451 17445-17447 IN denotes of
T4452 17448-17450 NN denotes HK
T4453 17451-17459 NNS denotes isozymes
T4454 17460-17463 CC denotes and
T4455 17464-17471 NN denotes glucose
T4456 17472-17483 NN denotes utilization
T4457 17484-17486 IN denotes in
T4458 17487-17490 DT denotes the
T4459 17491-17494 NN denotes CNS
T4460 17495-17496 -LRB- denotes [
T4462 17496-17498 CD denotes 33
T4463 17498-17499 , denotes ,
T4461 17499-17501 CD denotes 34
T4464 17501-17502 -RRB- denotes ]
T4465 17502-17503 . denotes .
T4466 17503-17800 sentence denotes Moreover, glucose is the sole reliance source of energy in the CNS under normal conditions, the CNS lacks glucose storage sources, and despite the disproportionate mass of the CNS to the rest of the body, the CNS consumes daily about 60% of the body's glucose and 25% of the total oxygen [35,36].
T4467 17504-17512 RB denotes Moreover
T4469 17512-17514 , denotes ,
T4470 17514-17521 NN denotes glucose
T4468 17522-17524 VBZ denotes is
T4471 17525-17528 DT denotes the
T4473 17529-17533 JJ denotes sole
T4474 17534-17542 NN denotes reliance
T4472 17543-17549 NN denotes source
T4475 17550-17552 IN denotes of
T4476 17553-17559 NN denotes energy
T4477 17560-17562 IN denotes in
T4478 17563-17566 DT denotes the
T4479 17567-17570 NN denotes CNS
T4480 17571-17576 IN denotes under
T4481 17577-17583 JJ denotes normal
T4482 17584-17594 NNS denotes conditions
T4483 17594-17596 , denotes ,
T4484 17596-17599 DT denotes the
T4485 17600-17603 NN denotes CNS
T4486 17604-17609 VBZ denotes lacks
T4487 17610-17617 NN denotes glucose
T4488 17618-17625 NN denotes storage
T4489 17626-17633 NNS denotes sources
T4490 17633-17635 , denotes ,
T4491 17635-17638 CC denotes and
T4492 17639-17646 IN denotes despite
T4494 17647-17650 DT denotes the
T4496 17651-17667 JJ denotes disproportionate
T4495 17668-17672 NN denotes mass
T4497 17673-17675 IN denotes of
T4498 17676-17679 DT denotes the
T4499 17680-17683 NN denotes CNS
T4500 17684-17686 IN denotes to
T4501 17687-17690 DT denotes the
T4502 17691-17695 NN denotes rest
T4503 17696-17698 IN denotes of
T4504 17699-17702 DT denotes the
T4505 17703-17707 NN denotes body
T4506 17707-17709 , denotes ,
T4507 17709-17712 DT denotes the
T4508 17713-17716 NN denotes CNS
T4493 17717-17725 VBZ denotes consumes
T4509 17726-17731 RB denotes daily
T4510 17732-17737 IN denotes about
T4511 17738-17740 CD denotes 60
T4512 17740-17741 NN denotes %
T4513 17742-17744 IN denotes of
T4514 17745-17748 DT denotes the
T4515 17749-17753 NN denotes body
T4517 17753-17755 POS denotes 's
T4516 17756-17763 NN denotes glucose
T4518 17764-17767 CC denotes and
T4519 17768-17770 CD denotes 25
T4520 17770-17771 NN denotes %
T4521 17772-17774 IN denotes of
T4522 17775-17778 DT denotes the
T4524 17779-17784 JJ denotes total
T4523 17785-17791 NN denotes oxygen
T4525 17792-17793 -LRB- denotes [
T4527 17793-17795 CD denotes 35
T4528 17795-17796 , denotes ,
T4526 17796-17798 CD denotes 36
T4529 17798-17799 -RRB- denotes ]
T4530 17799-17800 . denotes .
T4531 17800-17952 sentence denotes To determine the impact of RanBP2 haploinsufficiency on the utilization, formation, and uptake of glucose, we carried out several physiological assays.
T4532 17801-17803 TO denotes To
T4533 17804-17813 VB denotes determine
T4535 17814-17817 DT denotes the
T4536 17818-17824 NN denotes impact
T4537 17825-17827 IN denotes of
T4538 17828-17834 NN denotes RanBP2
T4539 17835-17853 NN denotes haploinsufficiency
T4540 17854-17856 IN denotes on
T4541 17857-17860 DT denotes the
T4542 17861-17872 NN denotes utilization
T4543 17872-17874 , denotes ,
T4544 17874-17883 NN denotes formation
T4545 17883-17885 , denotes ,
T4546 17885-17888 CC denotes and
T4547 17889-17895 NN denotes uptake
T4548 17896-17898 IN denotes of
T4549 17899-17906 NN denotes glucose
T4550 17906-17908 , denotes ,
T4551 17908-17910 PRP denotes we
T4534 17911-17918 VBD denotes carried
T4552 17919-17922 RP denotes out
T4553 17923-17930 JJ denotes several
T4555 17931-17944 JJ denotes physiological
T4554 17945-17951 NNS denotes assays
T4556 17951-17952 . denotes .
T4557 17952-18263 sentence denotes In contrast to mice placed on a normal chow diet (~5% fat; unpublished data), RanBP2+/−mice on a higher fat diet (~10% fat) performed significantly worse in the glucose tolerance test beginning at 6 mo of age (Figure 7A and 7B), thus supporting that the RanBP2+/− mice exhibited a deficit in glucose clearance.
T4558 17953-17955 IN denotes In
T4560 17956-17964 NN denotes contrast
T4561 17965-17967 IN denotes to
T4562 17968-17972 NNS denotes mice
T4563 17973-17979 VBN denotes placed
T4564 17980-17982 IN denotes on
T4565 17983-17984 DT denotes a
T4567 17985-17991 JJ denotes normal
T4568 17992-17996 NN denotes chow
T4566 17997-18001 NN denotes diet
T4569 18002-18003 -LRB- denotes (
T4571 18003-18004 SYM denotes ~
T4572 18004-18005 CD denotes 5
T4573 18005-18006 NN denotes %
T4574 18007-18010 NN denotes fat
T4575 18010-18011 : denotes ;
T4576 18012-18023 JJ denotes unpublished
T4570 18024-18028 NNS denotes data
T4577 18028-18029 -RRB- denotes )
T4578 18029-18031 , denotes ,
T4579 18031-18037 NN denotes RanBP2
T4581 18037-18038 SYM denotes +
T4582 18038-18039 HYPH denotes /
T4583 18039-18040 SYM denotes −
T4580 18040-18044 NNS denotes mice
T4584 18045-18047 IN denotes on
T4585 18048-18049 DT denotes a
T4587 18050-18056 JJR denotes higher
T4588 18057-18060 NN denotes fat
T4586 18061-18065 NN denotes diet
T4589 18066-18067 -LRB- denotes (
T4591 18067-18068 SYM denotes ~
T4592 18068-18070 CD denotes 10
T4593 18070-18071 NN denotes %
T4590 18072-18075 NN denotes fat
T4594 18075-18076 -RRB- denotes )
T4559 18077-18086 VBD denotes performed
T4595 18087-18100 RB denotes significantly
T4596 18101-18106 RBR denotes worse
T4597 18107-18109 IN denotes in
T4598 18110-18113 DT denotes the
T4600 18114-18121 NN denotes glucose
T4601 18122-18131 NN denotes tolerance
T4599 18132-18136 NN denotes test
T4602 18137-18146 VBG denotes beginning
T4603 18147-18149 IN denotes at
T4604 18150-18151 CD denotes 6
T4605 18152-18154 NNS denotes mo
T4606 18155-18157 IN denotes of
T4607 18158-18161 NN denotes age
T4608 18162-18163 -LRB- denotes (
T4610 18163-18169 NN denotes Figure
T4609 18170-18172 NN denotes 7A
T4611 18173-18176 CC denotes and
T4612 18177-18179 NN denotes 7B
T4613 18179-18180 -RRB- denotes )
T4614 18180-18182 , denotes ,
T4615 18182-18186 RB denotes thus
T4616 18187-18197 VBG denotes supporting
T4617 18198-18202 IN denotes that
T4619 18203-18206 DT denotes the
T4621 18207-18213 NN denotes RanBP2
T4622 18213-18214 SYM denotes +
T4623 18214-18215 HYPH denotes /
T4624 18215-18216 SYM denotes −
T4620 18217-18221 NNS denotes mice
T4618 18222-18231 VBD denotes exhibited
T4625 18232-18233 DT denotes a
T4626 18234-18241 NN denotes deficit
T4627 18242-18244 IN denotes in
T4628 18245-18252 NN denotes glucose
T4629 18253-18262 NN denotes clearance
T4630 18262-18263 . denotes .
T4631 18263-18355 sentence denotes This deficit was rescued in RanBP2+/− mice of mixed C57BL/6J/129Ola background (Figure S3).
T4632 18264-18268 DT denotes This
T4633 18269-18276 NN denotes deficit
T4635 18277-18280 VBD denotes was
T4634 18281-18288 VBN denotes rescued
T4636 18289-18291 IN denotes in
T4637 18292-18298 NN denotes RanBP2
T4639 18298-18299 SYM denotes +
T4640 18299-18300 HYPH denotes /
T4641 18300-18301 SYM denotes −
T4638 18302-18306 NNS denotes mice
T4642 18307-18309 IN denotes of
T4643 18310-18315 VBN denotes mixed
T4645 18316-18321 NN denotes C57BL
T4647 18321-18322 HYPH denotes /
T4648 18322-18324 NN denotes 6J
T4649 18324-18325 HYPH denotes /
T4646 18325-18331 NN denotes 129Ola
T4644 18332-18342 NN denotes background
T4650 18343-18344 -LRB- denotes (
T4652 18344-18350 NN denotes Figure
T4651 18351-18353 NN denotes S3
T4653 18353-18354 -RRB- denotes )
T4654 18354-18355 . denotes .
T4655 18355-18459 sentence denotes Glucose clearance was not affected due to a disturbance in insulin-mediated glucose uptake (Figure 7C).
T4656 18356-18363 NN denotes Glucose
T4657 18364-18373 NN denotes clearance
T4659 18374-18377 VBD denotes was
T4660 18378-18381 RB denotes not
T4658 18382-18390 VBN denotes affected
T4661 18391-18394 IN denotes due
T4662 18395-18397 IN denotes to
T4663 18398-18399 DT denotes a
T4664 18400-18411 NN denotes disturbance
T4665 18412-18414 IN denotes in
T4666 18415-18422 NN denotes insulin
T4668 18422-18423 HYPH denotes -
T4667 18423-18431 JJ denotes mediated
T4670 18432-18439 NN denotes glucose
T4669 18440-18446 NN denotes uptake
T4671 18447-18448 -LRB- denotes (
T4673 18448-18454 NN denotes Figure
T4672 18455-18457 NN denotes 7C
T4674 18457-18458 -RRB- denotes )
T4675 18458-18459 . denotes .
T4676 18459-18615 sentence denotes Then, we probed whether RanBP2 induces impairment of gluconeogenesis, which could contribute to the pathophysiological production and clearance of glucose.
T4677 18460-18464 RB denotes Then
T4679 18464-18466 , denotes ,
T4680 18466-18468 PRP denotes we
T4678 18469-18475 VBD denotes probed
T4681 18476-18483 IN denotes whether
T4683 18484-18490 NN denotes RanBP2
T4682 18491-18498 VBZ denotes induces
T4684 18499-18509 NN denotes impairment
T4685 18510-18512 IN denotes of
T4686 18513-18528 NN denotes gluconeogenesis
T4687 18528-18530 , denotes ,
T4688 18530-18535 WDT denotes which
T4690 18536-18541 MD denotes could
T4689 18542-18552 VB denotes contribute
T4691 18553-18555 IN denotes to
T4692 18556-18559 DT denotes the
T4694 18560-18578 JJ denotes pathophysiological
T4693 18579-18589 NN denotes production
T4695 18590-18593 CC denotes and
T4696 18594-18603 NN denotes clearance
T4697 18604-18606 IN denotes of
T4698 18607-18614 NN denotes glucose
T4699 18614-18615 . denotes .
T4700 18615-18814 sentence denotes To this end, the administration of the gluconeogenic substrate precursor, pyruvate (pyruvate tolerance test), showed that there was no difference in glucose production in RanBP2+/− mice (Figure 7D).
T4701 18616-18618 IN denotes To
T4703 18619-18623 DT denotes this
T4704 18624-18627 NN denotes end
T4705 18627-18629 , denotes ,
T4706 18629-18632 DT denotes the
T4707 18633-18647 NN denotes administration
T4708 18648-18650 IN denotes of
T4709 18651-18654 DT denotes the
T4711 18655-18668 JJ denotes gluconeogenic
T4712 18669-18678 NN denotes substrate
T4710 18679-18688 NN denotes precursor
T4713 18688-18690 , denotes ,
T4714 18690-18698 NN denotes pyruvate
T4715 18699-18700 -LRB- denotes (
T4716 18700-18708 NN denotes pyruvate
T4717 18709-18718 NN denotes tolerance
T4718 18719-18723 NN denotes test
T4719 18723-18724 -RRB- denotes )
T4720 18724-18726 , denotes ,
T4702 18726-18732 VBD denotes showed
T4721 18733-18737 IN denotes that
T4723 18738-18743 EX denotes there
T4722 18744-18747 VBD denotes was
T4724 18748-18750 DT denotes no
T4725 18751-18761 NN denotes difference
T4726 18762-18764 IN denotes in
T4727 18765-18772 NN denotes glucose
T4728 18773-18783 NN denotes production
T4729 18784-18786 IN denotes in
T4730 18787-18793 NN denotes RanBP2
T4732 18793-18794 SYM denotes +
T4733 18794-18795 HYPH denotes /
T4734 18795-18796 SYM denotes −
T4731 18797-18801 NNS denotes mice
T4735 18802-18803 -LRB- denotes (
T4737 18803-18809 NN denotes Figure
T4736 18810-18812 NN denotes 7D
T4738 18812-18813 -RRB- denotes )
T4739 18813-18814 . denotes .
T4740 18814-18902 sentence denotes Hence, partial loss-of-function of RanBP2 had no impact on the gluconeogenesis pathway.
T4741 18815-18820 RB denotes Hence
T4743 18820-18822 , denotes ,
T4744 18822-18829 JJ denotes partial
T4745 18830-18834 NN denotes loss
T4746 18834-18835 HYPH denotes -
T4747 18835-18837 IN denotes of
T4748 18837-18838 HYPH denotes -
T4749 18838-18846 NN denotes function
T4750 18847-18849 IN denotes of
T4751 18850-18856 NN denotes RanBP2
T4742 18857-18860 VBD denotes had
T4752 18861-18863 DT denotes no
T4753 18864-18870 NN denotes impact
T4754 18871-18873 IN denotes on
T4755 18874-18877 DT denotes the
T4757 18878-18893 NN denotes gluconeogenesis
T4756 18894-18901 NN denotes pathway
T4758 18901-18902 . denotes .
T4759 18902-19104 sentence denotes However, upon glucose production (15 min), the clearance rates of glucose were again significantly slower in RanBP2+/− than in RanBP2+/+ mice (Figure 7D), confirming an impairment in glucose breakdown.
T4760 18903-18910 RB denotes However
T4762 18910-18912 , denotes ,
T4763 18912-18916 IN denotes upon
T4764 18917-18924 NN denotes glucose
T4765 18925-18935 NN denotes production
T4766 18936-18937 -LRB- denotes (
T4768 18937-18939 CD denotes 15
T4767 18940-18943 NNS denotes min
T4769 18943-18944 -RRB- denotes )
T4770 18944-18946 , denotes ,
T4771 18946-18949 DT denotes the
T4773 18950-18959 NN denotes clearance
T4772 18960-18965 NNS denotes rates
T4774 18966-18968 IN denotes of
T4775 18969-18976 NN denotes glucose
T4761 18977-18981 VBD denotes were
T4776 18982-18987 RB denotes again
T4777 18988-19001 RB denotes significantly
T4778 19002-19008 JJR denotes slower
T4779 19009-19011 IN denotes in
T4780 19012-19018 NN denotes RanBP2
T4781 19018-19019 SYM denotes +
T4782 19019-19020 HYPH denotes /
T4783 19020-19021 SYM denotes −
T4784 19022-19026 IN denotes than
T4785 19027-19029 IN denotes in
T4786 19030-19036 NN denotes RanBP2
T4788 19036-19037 SYM denotes +
T4789 19037-19038 HYPH denotes /
T4790 19038-19039 SYM denotes +
T4787 19040-19044 NNS denotes mice
T4791 19045-19046 -LRB- denotes (
T4793 19046-19052 NN denotes Figure
T4792 19053-19055 NN denotes 7D
T4794 19055-19056 -RRB- denotes )
T4795 19056-19058 , denotes ,
T4796 19058-19068 VBG denotes confirming
T4797 19069-19071 DT denotes an
T4798 19072-19082 NN denotes impairment
T4799 19083-19085 IN denotes in
T4800 19086-19093 NN denotes glucose
T4801 19094-19103 NN denotes breakdown
T4802 19103-19104 . denotes .
T13772 19115-19124 JJ denotes Metabolic
T13773 19125-19135 NNS denotes Phenotypes
T13774 19136-19138 IN denotes of
T13775 19139-19145 NN denotes RanBP2
T13777 19145-19146 SYM denotes +
T13778 19146-19147 HYPH denotes /
T13779 19147-19148 SYM denotes −
T13780 19149-19155 JJ denotes Inbred
T13776 19156-19160 NNS denotes Mice
T13781 19161-19163 IN denotes on
T13782 19164-19168 JJ denotes High
T13784 19168-19169 HYPH denotes -
T13783 19169-19172 NN denotes Fat
T13785 19173-19177 NN denotes Diet
T13786 19177-19302 sentence denotes (A) 3-mo-old inbred RanBP2+/− mice (n = 5) have normal glucose clearance rates upon glucose challenge and overnight fasting.
T13787 19178-19179 -LRB- denotes (
T13788 19179-19180 LS denotes A
T13790 19180-19181 -RRB- denotes )
T13791 19182-19183 CD denotes 3
T13793 19183-19184 HYPH denotes -
T13792 19184-19186 NN denotes mo
T13795 19186-19187 HYPH denotes -
T13794 19187-19190 JJ denotes old
T13797 19191-19197 JJ denotes inbred
T13798 19198-19204 NN denotes RanBP2
T13799 19204-19205 SYM denotes +
T13800 19205-19206 HYPH denotes /
T13801 19206-19207 SYM denotes −
T13796 19208-19212 NNS denotes mice
T13802 19213-19214 -LRB- denotes (
T13804 19214-19215 NN denotes n
T13805 19216-19217 SYM denotes =
T13803 19218-19219 CD denotes 5
T13806 19219-19220 -RRB- denotes )
T13789 19221-19225 VBP denotes have
T13807 19226-19232 JJ denotes normal
T13809 19233-19240 NN denotes glucose
T13810 19241-19250 NN denotes clearance
T13808 19251-19256 NNS denotes rates
T13811 19257-19261 IN denotes upon
T13812 19262-19269 NN denotes glucose
T13813 19270-19279 NN denotes challenge
T13814 19280-19283 CC denotes and
T13815 19284-19293 JJ denotes overnight
T13816 19294-19301 NN denotes fasting
T13817 19301-19302 . denotes .
T13818 19302-19457 sentence denotes (B) In contrast, 6-mo-old inbred RanBP2+/− mice (n = 5) have significantly decreased glucose clearance rates upon glucose challenge and overnight fasting.
T13819 19303-19304 -LRB- denotes (
T13820 19304-19305 LS denotes B
T13822 19305-19306 -RRB- denotes )
T13823 19307-19309 IN denotes In
T13824 19310-19318 NN denotes contrast
T13825 19318-19320 , denotes ,
T13826 19320-19321 CD denotes 6
T13828 19321-19322 HYPH denotes -
T13827 19322-19324 NN denotes mo
T13830 19324-19325 HYPH denotes -
T13829 19325-19328 JJ denotes old
T13832 19329-19335 JJ denotes inbred
T13833 19336-19342 NN denotes RanBP2
T13834 19342-19343 SYM denotes +
T13835 19343-19344 HYPH denotes /
T13836 19344-19345 SYM denotes −
T13831 19346-19350 NNS denotes mice
T13837 19351-19352 -LRB- denotes (
T13839 19352-19353 NN denotes n
T13840 19354-19355 SYM denotes =
T13838 19356-19357 CD denotes 5
T13841 19357-19358 -RRB- denotes )
T13821 19359-19363 VBP denotes have
T13842 19364-19377 RB denotes significantly
T13843 19378-19387 VBN denotes decreased
T13845 19388-19395 NN denotes glucose
T13846 19396-19405 NN denotes clearance
T13844 19406-19411 NNS denotes rates
T13847 19412-19416 IN denotes upon
T13848 19417-19424 NN denotes glucose
T13849 19425-19434 NN denotes challenge
T13850 19435-19438 CC denotes and
T13851 19439-19448 JJ denotes overnight
T13852 19449-19456 NN denotes fasting
T13853 19456-19457 . denotes .
T13854 19457-19612 sentence denotes (C) Fasted 6- to 8-mo-old RanBP2+/+ and RanBP2+/− mice have no difference in insulin-mediated glucose uptake as assayed by insulin tolerance test (n = 5).
T13855 19458-19459 -LRB- denotes (
T13856 19459-19460 LS denotes C
T13858 19460-19461 -RRB- denotes )
T13859 19462-19468 VBN denotes Fasted
T13861 19469-19470 CD denotes 6
T13863 19470-19471 HYPH denotes -
T13864 19472-19474 IN denotes to
T13862 19475-19476 CD denotes 8
T13866 19476-19477 HYPH denotes -
T13865 19477-19479 NN denotes mo
T13868 19479-19480 HYPH denotes -
T13867 19480-19483 JJ denotes old
T13869 19484-19490 NN denotes RanBP2
T13870 19490-19491 SYM denotes +
T13871 19491-19492 HYPH denotes /
T13872 19492-19493 SYM denotes +
T13873 19494-19497 CC denotes and
T13874 19498-19504 NN denotes RanBP2
T13875 19504-19505 SYM denotes +
T13876 19505-19506 HYPH denotes /
T13877 19506-19507 SYM denotes −
T13860 19508-19512 NNS denotes mice
T13857 19513-19517 VBP denotes have
T13878 19518-19520 DT denotes no
T13879 19521-19531 NN denotes difference
T13880 19532-19534 IN denotes in
T13881 19535-19542 NN denotes insulin
T13883 19542-19543 HYPH denotes -
T13882 19543-19551 JJ denotes mediated
T13885 19552-19559 NN denotes glucose
T13884 19560-19566 NN denotes uptake
T13886 19567-19569 IN denotes as
T13887 19570-19577 VBN denotes assayed
T13888 19578-19580 IN denotes by
T13889 19581-19588 NN denotes insulin
T13890 19589-19598 NN denotes tolerance
T13891 19599-19603 NN denotes test
T13892 19604-19605 -LRB- denotes (
T13894 19605-19606 NN denotes n
T13895 19607-19608 SYM denotes =
T13893 19609-19610 CD denotes 5
T13896 19610-19611 -RRB- denotes )
T13897 19611-19612 . denotes .
T13898 19612-19754 sentence denotes (D) Pyruvate tolerance test shows normal rise in glucose but decreased glucose clearance between inbred RanBP2+/+ and RanBP2+/− mice (n = 5).
T13899 19613-19614 -LRB- denotes (
T13900 19614-19615 LS denotes D
T13902 19615-19616 -RRB- denotes )
T13903 19617-19625 NN denotes Pyruvate
T13904 19626-19635 NN denotes tolerance
T13905 19636-19640 NN denotes test
T13901 19641-19646 VBZ denotes shows
T13906 19647-19653 JJ denotes normal
T13907 19654-19658 NN denotes rise
T13908 19659-19661 IN denotes in
T13909 19662-19669 NN denotes glucose
T13910 19670-19673 CC denotes but
T13911 19674-19683 VBN denotes decreased
T13913 19684-19691 NN denotes glucose
T13912 19692-19701 NN denotes clearance
T13914 19702-19709 IN denotes between
T13915 19710-19716 JJ denotes inbred
T13917 19717-19723 NN denotes RanBP2
T13918 19723-19724 SYM denotes +
T13919 19724-19725 HYPH denotes /
T13920 19725-19726 SYM denotes +
T13921 19727-19730 CC denotes and
T13922 19731-19737 NN denotes RanBP2
T13923 19737-19738 SYM denotes +
T13924 19738-19739 HYPH denotes /
T13925 19739-19740 SYM denotes −
T13916 19741-19745 NNS denotes mice
T13926 19746-19747 -LRB- denotes (
T13928 19747-19748 NN denotes n
T13929 19749-19750 SYM denotes =
T13927 19751-19752 CD denotes 5
T13930 19752-19753 -RRB- denotes )
T13931 19753-19754 . denotes .
T5002 19756-19774 NN denotes Haploinsufficiency
T5004 19775-19777 IN denotes of
T5005 19778-19784 NN denotes RanBP2
T5003 19785-19791 VBZ denotes Causes
T5006 19792-19800 NNS denotes Deficits
T5007 19801-19803 IN denotes in
T5008 19804-19807 DT denotes the
T5010 19808-19828 JJ denotes Electrophysiological
T5009 19829-19835 NN denotes Output
T5011 19836-19838 IN denotes of
T5012 19839-19849 JJ denotes Receptoral
T5014 19850-19853 CC denotes and
T5015 19854-19868 JJ denotes Postreceptoral
T5016 19869-19876 JJ denotes Retinal
T5013 19877-19884 NNS denotes Neurons
T5017 19884-20417 sentence denotes In light of the prominent expression of RanBP2 and HKI in retinal neurons [1,19], the vital dependence of the neuronal retina (and brain) on glucose as the main substrate source for energy production, and the determinant impact of metabolic disorders, such as diabetes, in retinal function (e.g., diabetic retinopathy) [37], we probed the impact of deficits in RanBP2, HKI, and ATP, on the electrophysiological responses of subclasses (rod and cone) photoreceptor and postreceptor retinal neurons of RanBP2+/− and in RanBP2+/+ mice.
T5018 19885-19887 IN denotes In
T5020 19888-19893 NN denotes light
T5021 19894-19896 IN denotes of
T5022 19897-19900 DT denotes the
T5024 19901-19910 JJ denotes prominent
T5023 19911-19921 NN denotes expression
T5025 19922-19924 IN denotes of
T5026 19925-19931 NN denotes RanBP2
T5027 19932-19935 CC denotes and
T5028 19936-19939 NN denotes HKI
T5029 19940-19942 IN denotes in
T5030 19943-19950 JJ denotes retinal
T5031 19951-19958 NNS denotes neurons
T5032 19959-19960 -LRB- denotes [
T5034 19960-19961 CD denotes 1
T5035 19961-19962 , denotes ,
T5033 19962-19964 CD denotes 19
T5036 19964-19965 -RRB- denotes ]
T5037 19965-19967 , denotes ,
T5038 19967-19970 DT denotes the
T5040 19971-19976 JJ denotes vital
T5039 19977-19987 NN denotes dependence
T5041 19988-19990 IN denotes of
T5042 19991-19994 DT denotes the
T5044 19995-20003 JJ denotes neuronal
T5043 20004-20010 NN denotes retina
T5045 20011-20012 -LRB- denotes (
T5046 20012-20015 CC denotes and
T5047 20016-20021 NN denotes brain
T5048 20021-20022 -RRB- denotes )
T5049 20023-20025 IN denotes on
T5050 20026-20033 NN denotes glucose
T5051 20034-20036 IN denotes as
T5052 20037-20040 DT denotes the
T5054 20041-20045 JJ denotes main
T5055 20046-20055 NN denotes substrate
T5053 20056-20062 NN denotes source
T5056 20063-20066 IN denotes for
T5057 20067-20073 NN denotes energy
T5058 20074-20084 NN denotes production
T5059 20084-20086 , denotes ,
T5060 20086-20089 CC denotes and
T5061 20090-20093 DT denotes the
T5063 20094-20105 JJ denotes determinant
T5062 20106-20112 NN denotes impact
T5064 20113-20115 IN denotes of
T5065 20116-20125 JJ denotes metabolic
T5066 20126-20135 NNS denotes disorders
T5067 20135-20137 , denotes ,
T5068 20137-20141 IN denotes such
T5069 20142-20144 IN denotes as
T5070 20145-20153 NN denotes diabetes
T5071 20153-20155 , denotes ,
T5072 20155-20157 IN denotes in
T5073 20158-20165 JJ denotes retinal
T5074 20166-20174 NN denotes function
T5075 20175-20176 -LRB- denotes (
T5076 20176-20180 FW denotes e.g.
T5078 20180-20182 , denotes ,
T5079 20182-20190 JJ denotes diabetic
T5077 20191-20202 NN denotes retinopathy
T5080 20202-20203 -RRB- denotes )
T5081 20204-20205 -LRB- denotes [
T5082 20205-20207 CD denotes 37
T5083 20207-20208 -RRB- denotes ]
T5084 20208-20210 , denotes ,
T5085 20210-20212 PRP denotes we
T5019 20213-20219 VBD denotes probed
T5086 20220-20223 DT denotes the
T5087 20224-20230 NN denotes impact
T5088 20231-20233 IN denotes of
T5089 20234-20242 NNS denotes deficits
T5090 20243-20245 IN denotes in
T5091 20246-20252 NN denotes RanBP2
T5092 20252-20254 , denotes ,
T5093 20254-20257 NN denotes HKI
T5094 20257-20259 , denotes ,
T5095 20259-20262 CC denotes and
T5096 20263-20266 NN denotes ATP
T5097 20266-20268 , denotes ,
T5098 20268-20270 IN denotes on
T5099 20271-20274 DT denotes the
T5101 20275-20295 JJ denotes electrophysiological
T5100 20296-20305 NNS denotes responses
T5102 20306-20308 IN denotes of
T5103 20309-20319 NNS denotes subclasses
T5105 20320-20321 -LRB- denotes (
T5106 20321-20324 NN denotes rod
T5107 20325-20328 CC denotes and
T5108 20329-20333 NN denotes cone
T5109 20333-20334 -RRB- denotes )
T5110 20335-20348 NN denotes photoreceptor
T5111 20349-20352 CC denotes and
T5112 20353-20365 NN denotes postreceptor
T5113 20366-20373 JJ denotes retinal
T5104 20374-20381 NNS denotes neurons
T5114 20382-20384 IN denotes of
T5115 20385-20391 NN denotes RanBP2
T5116 20391-20392 SYM denotes +
T5117 20392-20393 HYPH denotes /
T5118 20393-20394 SYM denotes −
T5119 20395-20398 CC denotes and
T5120 20399-20401 IN denotes in
T5121 20402-20408 NN denotes RanBP2
T5123 20408-20409 SYM denotes +
T5124 20409-20410 HYPH denotes /
T5125 20410-20411 SYM denotes +
T5122 20412-20416 NNS denotes mice
T5126 20416-20417 . denotes .
T5127 20417-20644 sentence denotes The scotopic (dark-adapted) responses mediated by the rod photoreceptor pathway at low-stimulus intensities and mixed rod and cone pathways at high-stimulus intensities were substantially reduced in RanBP2+/− mice (Figure 8A).
T5128 20418-20421 DT denotes The
T5130 20422-20430 JJ denotes scotopic
T5131 20431-20432 -LRB- denotes (
T5133 20432-20436 NN denotes dark
T5134 20436-20437 HYPH denotes -
T5132 20437-20444 VBN denotes adapted
T5135 20444-20445 -RRB- denotes )
T5129 20446-20455 NNS denotes responses
T5137 20456-20464 VBN denotes mediated
T5138 20465-20467 IN denotes by
T5139 20468-20471 DT denotes the
T5141 20472-20475 NN denotes rod
T5142 20476-20489 NN denotes photoreceptor
T5140 20490-20497 NN denotes pathway
T5143 20498-20500 IN denotes at
T5144 20501-20504 JJ denotes low
T5146 20504-20505 HYPH denotes -
T5145 20505-20513 NN denotes stimulus
T5147 20514-20525 NNS denotes intensities
T5148 20526-20529 CC denotes and
T5149 20530-20535 JJ denotes mixed
T5151 20536-20539 NN denotes rod
T5152 20540-20543 CC denotes and
T5153 20544-20548 NN denotes cone
T5150 20549-20557 NNS denotes pathways
T5154 20558-20560 IN denotes at
T5155 20561-20565 JJ denotes high
T5157 20565-20566 HYPH denotes -
T5156 20566-20574 NN denotes stimulus
T5158 20575-20586 NNS denotes intensities
T5159 20587-20591 VBD denotes were
T5160 20592-20605 RB denotes substantially
T5136 20606-20613 VBN denotes reduced
T5161 20614-20616 IN denotes in
T5162 20617-20623 NN denotes RanBP2
T5164 20623-20624 SYM denotes +
T5165 20624-20625 HYPH denotes /
T5166 20625-20626 SYM denotes −
T5163 20627-20631 NNS denotes mice
T5167 20632-20633 -LRB- denotes (
T5169 20633-20639 NN denotes Figure
T5168 20640-20642 NN denotes 8A
T5170 20642-20643 -RRB- denotes )
T5171 20643-20644 . denotes .
T5172 20644-20949 sentence denotes The differences in the photopic (light-adapted) responses, initiated by cone photoreceptors, which make up 3% of the photosensory neurons in the mouse retina [38], were less obvious but still exhibited a trend toward reduced amplitudes across a range of increasing light stimulus intensities (Figure 8B).
T5173 20645-20648 DT denotes The
T5174 20649-20660 NNS denotes differences
T5176 20661-20663 IN denotes in
T5177 20664-20667 DT denotes the
T5179 20668-20676 JJ denotes photopic
T5180 20677-20678 -LRB- denotes (
T5182 20678-20683 NN denotes light
T5183 20683-20684 HYPH denotes -
T5181 20684-20691 VBN denotes adapted
T5184 20691-20692 -RRB- denotes )
T5178 20693-20702 NNS denotes responses
T5185 20702-20704 , denotes ,
T5186 20704-20713 VBN denotes initiated
T5187 20714-20716 IN denotes by
T5188 20717-20721 NN denotes cone
T5189 20722-20736 NNS denotes photoreceptors
T5190 20736-20738 , denotes ,
T5191 20738-20743 WDT denotes which
T5192 20744-20748 VBP denotes make
T5193 20749-20751 RP denotes up
T5194 20752-20753 CD denotes 3
T5195 20753-20754 NN denotes %
T5196 20755-20757 IN denotes of
T5197 20758-20761 DT denotes the
T5199 20762-20774 JJ denotes photosensory
T5198 20775-20782 NNS denotes neurons
T5200 20783-20785 IN denotes in
T5201 20786-20789 DT denotes the
T5203 20790-20795 NN denotes mouse
T5202 20796-20802 NN denotes retina
T5204 20803-20804 -LRB- denotes [
T5205 20804-20806 CD denotes 38
T5206 20806-20807 -RRB- denotes ]
T5207 20807-20809 , denotes ,
T5175 20809-20813 VBD denotes were
T5208 20814-20818 RBR denotes less
T5209 20819-20826 JJ denotes obvious
T5210 20827-20830 CC denotes but
T5211 20831-20836 RB denotes still
T5212 20837-20846 VBD denotes exhibited
T5213 20847-20848 DT denotes a
T5214 20849-20854 NN denotes trend
T5215 20855-20861 IN denotes toward
T5216 20862-20869 VBN denotes reduced
T5217 20870-20880 NNS denotes amplitudes
T5218 20881-20887 IN denotes across
T5219 20888-20889 DT denotes a
T5220 20890-20895 NN denotes range
T5221 20896-20898 IN denotes of
T5222 20899-20909 VBG denotes increasing
T5224 20910-20915 JJ denotes light
T5225 20916-20924 NN denotes stimulus
T5223 20925-20936 NNS denotes intensities
T5226 20937-20938 -LRB- denotes (
T5228 20938-20944 NN denotes Figure
T5227 20945-20947 NN denotes 8B
T5229 20947-20948 -RRB- denotes )
T5230 20948-20949 . denotes .
T5231 20949-21134 sentence denotes The reduction in the scotopic responses included decreases in both b-wave (Figure 8C) and a-wave (Figure 8D) amplitudes mediated by postreceptoral and receptoral neurons, respectively.
T5232 20950-20953 DT denotes The
T5233 20954-20963 NN denotes reduction
T5235 20964-20966 IN denotes in
T5236 20967-20970 DT denotes the
T5238 20971-20979 JJ denotes scotopic
T5237 20980-20989 NNS denotes responses
T5234 20990-20998 VBD denotes included
T5239 20999-21008 NNS denotes decreases
T5240 21009-21011 IN denotes in
T5241 21012-21016 CC denotes both
T5243 21017-21018 NN denotes b
T5244 21018-21019 HYPH denotes -
T5242 21019-21023 NN denotes wave
T5246 21024-21025 -LRB- denotes (
T5248 21025-21031 NN denotes Figure
T5247 21032-21034 NN denotes 8C
T5249 21034-21035 -RRB- denotes )
T5250 21036-21039 CC denotes and
T5251 21040-21041 NN denotes a
T5253 21041-21042 HYPH denotes -
T5252 21042-21046 NN denotes wave
T5254 21047-21048 -LRB- denotes (
T5256 21048-21054 NN denotes Figure
T5255 21055-21057 NN denotes 8D
T5257 21057-21058 -RRB- denotes )
T5245 21059-21069 NNS denotes amplitudes
T5258 21070-21078 VBN denotes mediated
T5259 21079-21081 IN denotes by
T5260 21082-21096 JJ denotes postreceptoral
T5262 21097-21100 CC denotes and
T5263 21101-21111 JJ denotes receptoral
T5261 21112-21119 NNS denotes neurons
T5264 21119-21121 , denotes ,
T5265 21121-21133 RB denotes respectively
T5266 21133-21134 . denotes .
T5267 21134-21329 sentence denotes Postreceptoral second-order neuron responses, represented by the b-wave, tended to be more consistently and substantially reduced than the a-waves, which directly reflect photoreceptor activity.
T5268 21135-21149 JJ denotes Postreceptoral
T5270 21150-21156 JJ denotes second
T5272 21156-21157 HYPH denotes -
T5271 21157-21162 NN denotes order
T5273 21163-21169 NN denotes neuron
T5269 21170-21179 NNS denotes responses
T5275 21179-21181 , denotes ,
T5276 21181-21192 VBN denotes represented
T5277 21193-21195 IN denotes by
T5278 21196-21199 DT denotes the
T5280 21200-21201 NN denotes b
T5281 21201-21202 HYPH denotes -
T5279 21202-21206 NN denotes wave
T5282 21206-21208 , denotes ,
T5274 21208-21214 VBD denotes tended
T5283 21215-21217 TO denotes to
T5284 21218-21220 VB denotes be
T5285 21221-21225 RBR denotes more
T5287 21226-21238 RB denotes consistently
T5288 21239-21242 CC denotes and
T5289 21243-21256 RB denotes substantially
T5286 21257-21264 VBN denotes reduced
T5290 21265-21269 IN denotes than
T5291 21270-21273 DT denotes the
T5293 21274-21275 NN denotes a
T5294 21275-21276 HYPH denotes -
T5292 21276-21281 NNS denotes waves
T5295 21281-21283 , denotes ,
T5296 21283-21288 WDT denotes which
T5298 21289-21297 RB denotes directly
T5297 21298-21305 VBP denotes reflect
T5299 21306-21319 NN denotes photoreceptor
T5300 21320-21328 NN denotes activity
T5301 21328-21329 . denotes .
T5302 21329-21568 sentence denotes Since second-order neuron responses depend on input from photoreceptors, this suggests that reduced b-wave amplitudes are the result of the accumulation of decreases in the light response of both photoreceptors and postreceptoral neurons.
T5303 21330-21335 IN denotes Since
T5305 21336-21342 JJ denotes second
T5307 21342-21343 HYPH denotes -
T5306 21343-21348 NN denotes order
T5309 21349-21355 NN denotes neuron
T5308 21356-21365 NNS denotes responses
T5304 21366-21372 VBP denotes depend
T5311 21373-21375 IN denotes on
T5312 21376-21381 NN denotes input
T5313 21382-21386 IN denotes from
T5314 21387-21401 NNS denotes photoreceptors
T5315 21401-21403 , denotes ,
T5316 21403-21407 DT denotes this
T5310 21408-21416 VBZ denotes suggests
T5317 21417-21421 IN denotes that
T5319 21422-21429 VBN denotes reduced
T5321 21430-21431 NN denotes b
T5323 21431-21432 HYPH denotes -
T5322 21432-21436 NN denotes wave
T5320 21437-21447 NNS denotes amplitudes
T5318 21448-21451 VBP denotes are
T5324 21452-21455 DT denotes the
T5325 21456-21462 NN denotes result
T5326 21463-21465 IN denotes of
T5327 21466-21469 DT denotes the
T5328 21470-21482 NN denotes accumulation
T5329 21483-21485 IN denotes of
T5330 21486-21495 NNS denotes decreases
T5331 21496-21498 IN denotes in
T5332 21499-21502 DT denotes the
T5334 21503-21508 JJ denotes light
T5333 21509-21517 NN denotes response
T5335 21518-21520 IN denotes of
T5336 21521-21525 CC denotes both
T5337 21526-21540 NNS denotes photoreceptors
T5338 21541-21544 CC denotes and
T5339 21545-21559 JJ denotes postreceptoral
T5340 21560-21567 NNS denotes neurons
T5341 21567-21568 . denotes .
T5342 21568-21710 sentence denotes Anesthetics, particularly ketamine, can cause sustained elevation of glucose in mice, which in turn affects electroretinogram responses [39].
T5343 21569-21580 NNS denotes Anesthetics
T5345 21580-21582 , denotes ,
T5346 21582-21594 RB denotes particularly
T5347 21595-21603 NN denotes ketamine
T5348 21603-21605 , denotes ,
T5349 21605-21608 MD denotes can
T5344 21609-21614 VB denotes cause
T5350 21615-21624 JJ denotes sustained
T5351 21625-21634 NN denotes elevation
T5352 21635-21637 IN denotes of
T5353 21638-21645 NN denotes glucose
T5354 21646-21648 IN denotes in
T5355 21649-21653 NNS denotes mice
T5356 21653-21655 , denotes ,
T5357 21655-21660 WDT denotes which
T5359 21661-21663 IN denotes in
T5360 21664-21668 NN denotes turn
T5358 21669-21676 VBZ denotes affects
T5361 21677-21694 NN denotes electroretinogram
T5362 21695-21704 NNS denotes responses
T5363 21705-21706 -LRB- denotes [
T5364 21706-21708 CD denotes 39
T5365 21708-21709 -RRB- denotes ]
T5366 21709-21710 . denotes .
T5367 21710-21891 sentence denotes Thus, we were concerned that differences in electroretinogram amplitudes between RanBP2+/− and RanBP2+/+ may reflect differences in glucose level changes in response to anesthesia.
T5368 21711-21715 RB denotes Thus
T5370 21715-21717 , denotes ,
T5371 21717-21719 PRP denotes we
T5369 21720-21724 VBD denotes were
T5372 21725-21734 JJ denotes concerned
T5373 21735-21739 IN denotes that
T5375 21740-21751 NNS denotes differences
T5376 21752-21754 IN denotes in
T5377 21755-21772 NN denotes electroretinogram
T5378 21773-21783 NNS denotes amplitudes
T5379 21784-21791 IN denotes between
T5380 21792-21798 NN denotes RanBP2
T5381 21798-21799 SYM denotes +
T5382 21799-21800 HYPH denotes /
T5383 21800-21801 SYM denotes −
T5384 21802-21805 CC denotes and
T5385 21806-21812 NN denotes RanBP2
T5386 21812-21813 SYM denotes +
T5387 21813-21814 HYPH denotes /
T5388 21814-21815 SYM denotes +
T5389 21816-21819 MD denotes may
T5374 21820-21827 VB denotes reflect
T5390 21828-21839 NNS denotes differences
T5391 21840-21842 IN denotes in
T5392 21843-21850 NN denotes glucose
T5393 21851-21856 NN denotes level
T5394 21857-21864 NNS denotes changes
T5395 21865-21867 IN denotes in
T5396 21868-21876 NN denotes response
T5397 21877-21879 IN denotes to
T5398 21880-21890 NN denotes anesthesia
T5399 21890-21891 . denotes .
T5400 21891-22026 sentence denotes However, we found no significant differences in glucose levels measured before and every 15 min during 75 min of anesthesia (n = 4–5).
T5401 21892-21899 RB denotes However
T5403 21899-21901 , denotes ,
T5404 21901-21903 PRP denotes we
T5402 21904-21909 VBD denotes found
T5405 21910-21912 DT denotes no
T5407 21913-21924 JJ denotes significant
T5406 21925-21936 NNS denotes differences
T5408 21937-21939 IN denotes in
T5409 21940-21947 NN denotes glucose
T5410 21948-21954 NNS denotes levels
T5411 21955-21963 VBN denotes measured
T5412 21964-21970 IN denotes before
T5413 21971-21974 CC denotes and
T5414 21975-21980 DT denotes every
T5416 21981-21983 CD denotes 15
T5415 21984-21987 NNS denotes min
T5417 21988-21994 IN denotes during
T5419 21995-21997 CD denotes 75
T5418 21998-22001 NNS denotes min
T5420 22002-22004 IN denotes of
T5421 22005-22015 NN denotes anesthesia
T5422 22016-22017 -LRB- denotes (
T5424 22017-22018 NN denotes n
T5425 22019-22020 SYM denotes =
T5426 22021-22022 CD denotes 4
T5427 22022-22023 SYM denotes –
T5423 22023-22024 CD denotes 5
T5428 22024-22025 -RRB- denotes )
T5429 22025-22026 . denotes .
T5430 22026-22168 sentence denotes Glucose rose at the same rate and reached a maximum of approximately 3.3 times the pre-anesthesia level in both genotypes (unpublished data).
T5431 22027-22034 NN denotes Glucose
T5432 22035-22039 VBD denotes rose
T5433 22040-22042 IN denotes at
T5434 22043-22046 DT denotes the
T5436 22047-22051 JJ denotes same
T5435 22052-22056 NN denotes rate
T5437 22057-22060 CC denotes and
T5438 22061-22068 VBD denotes reached
T5439 22069-22070 DT denotes a
T5440 22071-22078 NN denotes maximum
T5441 22079-22081 IN denotes of
T5442 22082-22095 RB denotes approximately
T5443 22096-22099 CD denotes 3.3
T5445 22100-22105 NNS denotes times
T5446 22106-22109 DT denotes the
T5447 22110-22124 JJ denotes pre-anesthesia
T5444 22125-22130 NN denotes level
T5448 22131-22133 IN denotes in
T5449 22134-22138 DT denotes both
T5450 22139-22148 NNS denotes genotypes
T5451 22149-22150 -LRB- denotes (
T5453 22150-22161 JJ denotes unpublished
T5452 22162-22166 NNS denotes data
T5454 22166-22167 -RRB- denotes )
T5455 22167-22168 . denotes .
T14065 22179-22197 NNS denotes Electroretinograms
T14066 22198-22202 IN denotes from
T14067 22203-22204 CD denotes 6
T14069 22204-22205 HYPH denotes -
T14068 22205-22207 NN denotes Mo
T14071 22207-22208 HYPH denotes -
T14070 22208-22211 JJ denotes Old
T14073 22212-22218 NN denotes RanBP2
T14074 22218-22219 SYM denotes +
T14075 22219-22220 HYPH denotes /
T14076 22220-22221 SYM denotes −
T14077 22221-22224 CC denotes and
T14078 22225-22231 NN denotes RanBP2
T14079 22231-22232 SYM denotes +
T14080 22232-22233 HYPH denotes /
T14081 22233-22234 SYM denotes +
T14082 22235-22241 JJ denotes Inbred
T14072 22242-22246 NNS denotes Mice
T14083 22247-22254 VBG denotes Showing
T14084 22255-22268 NN denotes Photoreceptor
T14086 22269-22272 CC denotes and
T14087 22273-22285 NN denotes Postreceptor
T14085 22286-22292 NN denotes Neuron
T14089 22293-22313 JJ denotes Electrophysiological
T14090 22314-22322 NN denotes Response
T14088 22323-22333 NNS denotes Phenotypes
T14091 22333-22527 sentence denotes (A) Scotopic (dark-adapted) responses from RanBP2+/− mice to light stimuli of increasing intensity, beginning at threshold, have reduced amplitudes compared to those observed in RanBP2+/+ mice.
T14092 22334-22335 -LRB- denotes (
T14093 22335-22336 LS denotes A
T14095 22336-22337 -RRB- denotes )
T14096 22338-22346 JJ denotes Scotopic
T14098 22347-22348 -LRB- denotes (
T14100 22348-22352 NN denotes dark
T14101 22352-22353 HYPH denotes -
T14099 22353-22360 VBN denotes adapted
T14102 22360-22361 -RRB- denotes )
T14097 22362-22371 NNS denotes responses
T14103 22372-22376 IN denotes from
T14104 22377-22383 NN denotes RanBP2
T14106 22383-22384 SYM denotes +
T14107 22384-22385 HYPH denotes /
T14108 22385-22386 SYM denotes −
T14105 22387-22391 NNS denotes mice
T14109 22392-22394 IN denotes to
T14110 22395-22400 JJ denotes light
T14111 22401-22408 NNS denotes stimuli
T14112 22409-22411 IN denotes of
T14113 22412-22422 VBG denotes increasing
T14114 22423-22432 NN denotes intensity
T14115 22432-22434 , denotes ,
T14116 22434-22443 VBG denotes beginning
T14117 22444-22446 IN denotes at
T14118 22447-22456 NN denotes threshold
T14119 22456-22458 , denotes ,
T14094 22458-22462 VBP denotes have
T14120 22463-22470 JJ denotes reduced
T14121 22471-22481 NNS denotes amplitudes
T14122 22482-22490 VBN denotes compared
T14123 22491-22493 IN denotes to
T14124 22494-22499 DT denotes those
T14125 22500-22508 VBN denotes observed
T14126 22509-22511 IN denotes in
T14127 22512-22518 NN denotes RanBP2
T14129 22518-22519 SYM denotes +
T14130 22519-22520 HYPH denotes /
T14131 22520-22521 SYM denotes +
T14128 22522-22526 NNS denotes mice
T14132 22526-22527 . denotes .
T14133 22527-22628 sentence denotes The three lower intensities represent responses generated in the rod photoreceptor neuronal pathway.
T14134 22528-22531 DT denotes The
T14136 22532-22537 CD denotes three
T14137 22538-22543 JJR denotes lower
T14135 22544-22555 NNS denotes intensities
T14138 22556-22565 VBP denotes represent
T14139 22566-22575 NNS denotes responses
T14140 22576-22585 VBN denotes generated
T14141 22586-22588 IN denotes in
T14142 22589-22592 DT denotes the
T14144 22593-22596 NN denotes rod
T14145 22597-22610 NN denotes photoreceptor
T14146 22611-22619 JJ denotes neuronal
T14143 22620-22627 NN denotes pathway
T14147 22627-22628 . denotes .
T14148 22628-22722 sentence denotes The upper intensities are comprised of responses generated in both the rod and cone pathways.
T14149 22629-22632 DT denotes The
T14151 22633-22638 JJ denotes upper
T14150 22639-22650 NNS denotes intensities
T14153 22651-22654 VBP denotes are
T14152 22655-22664 VBN denotes comprised
T14154 22665-22667 IN denotes of
T14155 22668-22677 NNS denotes responses
T14156 22678-22687 VBN denotes generated
T14157 22688-22690 IN denotes in
T14158 22691-22695 CC denotes both
T14160 22696-22699 DT denotes the
T14161 22700-22703 NN denotes rod
T14162 22704-22707 CC denotes and
T14163 22708-22712 NN denotes cone
T14159 22713-22721 NNS denotes pathways
T14164 22721-22722 . denotes .
T14165 22722-22928 sentence denotes (B) Photopic (light-adapted, cone photoreceptor pathway) responses of RanBP2+/− mice to increasing light stimulus intensities also exhibited reduced amplitudes compared to those observed in RanBP2+/+ mice.
T14166 22723-22724 -LRB- denotes (
T14167 22724-22725 LS denotes B
T14169 22725-22726 -RRB- denotes )
T14170 22727-22735 JJ denotes Photopic
T14172 22736-22737 -LRB- denotes (
T14174 22737-22742 NN denotes light
T14176 22742-22743 HYPH denotes -
T14175 22743-22750 VBN denotes adapted
T14177 22750-22752 , denotes ,
T14178 22752-22756 NN denotes cone
T14179 22757-22770 NN denotes photoreceptor
T14173 22771-22778 NN denotes pathway
T14180 22778-22779 -RRB- denotes )
T14171 22780-22789 NNS denotes responses
T14181 22790-22792 IN denotes of
T14182 22793-22799 NN denotes RanBP2
T14184 22799-22800 SYM denotes +
T14185 22800-22801 HYPH denotes /
T14186 22801-22802 SYM denotes −
T14183 22803-22807 NNS denotes mice
T14187 22808-22810 IN denotes to
T14188 22811-22821 VBG denotes increasing
T14190 22822-22827 JJ denotes light
T14191 22828-22836 NN denotes stimulus
T14189 22837-22848 NNS denotes intensities
T14192 22849-22853 RB denotes also
T14168 22854-22863 VBD denotes exhibited
T14193 22864-22871 VBN denotes reduced
T14194 22872-22882 NNS denotes amplitudes
T14195 22883-22891 VBN denotes compared
T14196 22892-22894 IN denotes to
T14197 22895-22900 DT denotes those
T14198 22901-22909 VBN denotes observed
T14199 22910-22912 IN denotes in
T14200 22913-22919 NN denotes RanBP2
T14202 22919-22920 SYM denotes +
T14203 22920-22921 HYPH denotes /
T14204 22921-22922 SYM denotes +
T14201 22923-22927 NNS denotes mice
T14205 22927-22928 . denotes .
T14206 22928-23091 sentence denotes (C) Average ± SE (n = 9) scotopic b-wave amplitudes from RanBP2+/− (open circles) and RanBP2+/+ (filled squares) mice representing postreceptoral neuron function.
T14207 22929-22930 -LRB- denotes (
T14208 22930-22931 LS denotes C
T14210 22931-22932 -RRB- denotes )
T14211 22933-22940 NN denotes Average
T14213 22941-22942 SYM denotes ±
T14212 22943-22945 NN denotes SE
T14214 22946-22947 -LRB- denotes (
T14216 22947-22948 NN denotes n
T14217 22949-22950 SYM denotes =
T14215 22951-22952 CD denotes 9
T14218 22952-22953 -RRB- denotes )
T14219 22954-22962 JJ denotes scotopic
T14220 22963-22964 NN denotes b
T14222 22964-22965 HYPH denotes -
T14221 22965-22969 NN denotes wave
T14209 22970-22980 NNS denotes amplitudes
T14223 22981-22985 IN denotes from
T14224 22986-22992 NN denotes RanBP2
T14226 22992-22993 SYM denotes +
T14227 22993-22994 HYPH denotes /
T14228 22994-22995 SYM denotes −
T14229 22996-22997 -LRB- denotes (
T14231 22997-23001 JJ denotes open
T14230 23002-23009 NNS denotes circles
T14232 23009-23010 -RRB- denotes )
T14233 23011-23014 CC denotes and
T14234 23015-23021 NN denotes RanBP2
T14235 23021-23022 SYM denotes +
T14236 23022-23023 HYPH denotes /
T14237 23023-23024 SYM denotes +
T14238 23025-23026 -LRB- denotes (
T14240 23026-23032 VBN denotes filled
T14239 23033-23040 NNS denotes squares
T14241 23040-23041 -RRB- denotes )
T14225 23042-23046 NNS denotes mice
T14242 23047-23059 VBG denotes representing
T14243 23060-23074 JJ denotes postreceptoral
T14244 23075-23081 NN denotes neuron
T14245 23082-23090 NN denotes function
T14246 23090-23091 . denotes .
T14247 23091-23120 sentence denotes (Note: log amplitude scale.)
T14248 23092-23093 -LRB- denotes (
T14250 23093-23097 NN denotes Note
T14251 23097-23099 : denotes :
T14252 23099-23102 NN denotes log
T14253 23103-23112 NN denotes amplitude
T14249 23113-23118 NN denotes scale
T14254 23118-23119 . denotes .
T14255 23119-23120 -RRB- denotes )
T14256 23120-23274 sentence denotes (D) Average ± SE (n = 5) scotopic a-wave amplitudes, representing photoreceptor function, for RanBP2+/− and RanBP2+/+ mice in response to bright flashes.
T14257 23121-23122 -LRB- denotes (
T14258 23122-23123 LS denotes D
T14260 23123-23124 -RRB- denotes )
T14261 23125-23132 JJ denotes Average
T14263 23133-23134 SYM denotes ±
T14262 23135-23137 NN denotes SE
T14264 23138-23139 -LRB- denotes (
T14266 23139-23140 NN denotes n
T14267 23141-23142 SYM denotes =
T14265 23143-23144 CD denotes 5
T14268 23144-23145 -RRB- denotes )
T14269 23146-23154 JJ denotes scotopic
T14270 23155-23156 NN denotes a
T14272 23156-23157 HYPH denotes -
T14271 23157-23161 NN denotes wave
T14259 23162-23172 NNS denotes amplitudes
T14273 23172-23174 , denotes ,
T14274 23174-23186 VBG denotes representing
T14275 23187-23200 NN denotes photoreceptor
T14276 23201-23209 NN denotes function
T14277 23209-23211 , denotes ,
T14278 23211-23214 IN denotes for
T14279 23215-23221 NN denotes RanBP2
T14281 23221-23222 SYM denotes +
T14282 23222-23223 HYPH denotes /
T14283 23223-23224 SYM denotes −
T14284 23225-23228 CC denotes and
T14285 23229-23235 NN denotes RanBP2
T14286 23235-23236 SYM denotes +
T14287 23236-23237 HYPH denotes /
T14288 23237-23238 SYM denotes +
T14280 23239-23243 NNS denotes mice
T14289 23244-23246 IN denotes in
T14290 23247-23255 NN denotes response
T14291 23256-23258 IN denotes to
T14292 23259-23265 JJ denotes bright
T14293 23266-23273 NNS denotes flashes
T14294 23273-23274 . denotes .
T14295 23274-23400 sentence denotes Amplitudes of responses from RanBP2+/− mice were lower over the entire range of stimulus intensities for both b- and a-waves.
T14296 23275-23285 NNS denotes Amplitudes
T14298 23286-23288 IN denotes of
T14299 23289-23298 NNS denotes responses
T14300 23299-23303 IN denotes from
T14301 23304-23310 NN denotes RanBP2
T14303 23310-23311 SYM denotes +
T14304 23311-23312 HYPH denotes /
T14305 23312-23313 SYM denotes −
T14302 23314-23318 NNS denotes mice
T14297 23319-23323 VBD denotes were
T14306 23324-23329 JJR denotes lower
T14307 23330-23334 IN denotes over
T14308 23335-23338 DT denotes the
T14310 23339-23345 JJ denotes entire
T14309 23346-23351 NN denotes range
T14311 23352-23354 IN denotes of
T14312 23355-23363 NN denotes stimulus
T14313 23364-23375 NNS denotes intensities
T14314 23376-23379 IN denotes for
T14315 23380-23384 CC denotes both
T14316 23385-23386 NN denotes b
T14318 23386-23387 HYPH denotes -
T14319 23388-23391 CC denotes and
T14320 23392-23393 NN denotes a
T14321 23393-23394 HYPH denotes -
T14317 23394-23399 NNS denotes waves
T14322 23399-23400 . denotes .
T14323 23400-23493 sentence denotes Asterisks represent significant differences between the groups (Student's t test, p < 0.05).
T14324 23401-23410 NNS denotes Asterisks
T14325 23411-23420 VBP denotes represent
T14326 23421-23432 JJ denotes significant
T14327 23433-23444 NNS denotes differences
T14328 23445-23452 IN denotes between
T14329 23453-23456 DT denotes the
T14330 23457-23463 NNS denotes groups
T14331 23464-23465 -LRB- denotes (
T14333 23465-23472 NN denotes Student
T14334 23472-23474 POS denotes 's
T14335 23475-23476 NN denotes t
T14332 23477-23481 NN denotes test
T14336 23481-23483 , denotes ,
T14337 23483-23484 NN denotes p
T14339 23485-23486 SYM denotes <
T14338 23487-23491 CD denotes 0.05
T14340 23491-23492 -RRB- denotes )
T14341 23492-23493 . denotes .
T14342 23493-23624 sentence denotes Statistical significance was found across all intensities for b-wave amplitudes (2-way ANOVA, p < 0.0001), but not for the a-wave.
T14343 23494-23505 JJ denotes Statistical
T14344 23506-23518 NN denotes significance
T14346 23519-23522 VBD denotes was
T14345 23523-23528 VBN denotes found
T14347 23529-23535 IN denotes across
T14348 23536-23539 DT denotes all
T14349 23540-23551 NNS denotes intensities
T14350 23552-23555 IN denotes for
T14351 23556-23557 NN denotes b
T14353 23557-23558 HYPH denotes -
T14352 23558-23562 NN denotes wave
T14354 23563-23573 NNS denotes amplitudes
T14355 23574-23575 -LRB- denotes (
T14357 23575-23576 CD denotes 2
T14359 23576-23577 HYPH denotes -
T14358 23577-23580 NN denotes way
T14356 23581-23586 NNP denotes ANOVA
T14360 23586-23588 , denotes ,
T14361 23588-23589 NN denotes p
T14363 23590-23591 SYM denotes <
T14362 23592-23598 CD denotes 0.0001
T14364 23598-23599 -RRB- denotes )
T14365 23599-23601 , denotes ,
T14366 23601-23604 CC denotes but
T14367 23605-23608 RB denotes not
T14368 23609-23612 IN denotes for
T14369 23613-23616 DT denotes the
T14371 23617-23618 NN denotes a
T14372 23618-23619 HYPH denotes -
T14370 23619-23623 NN denotes wave
T14373 23623-23624 . denotes .
R1179 T2102 T2103 det The,LD
R1180 T2103 T2104 nsubj LD,Interacts
R1181 T2105 T2103 prep of,LD
R1182 T2106 T2105 pobj RanBP2,of
R1183 T2107 T2104 prep with,Interacts
R1184 T2108 T2107 pobj Cox11,with
R1185 T2109 T2108 cc and,Cox11
R1186 T2110 T2108 conj HKI,Cox11
R1187 T2112 T2113 det The,LD
R1188 T2113 T2114 nsubj LD,is
R1189 T2115 T2113 prep of,LD
R1190 T2116 T2115 pobj RanBP2,of
R1191 T2117 T2118 punct (,1A
R1192 T2118 T2113 parataxis 1A,LD
R1193 T2119 T2118 compound Figure,1A
R1194 T2120 T2118 punct ),1A
R1195 T2121 T2122 det a,domain
R1196 T2122 T2114 attr domain,is
R1197 T2123 T2122 amod large,domain
R1198 T2124 T2123 cc and,large
R1199 T2125 T2123 conj orphan,large
R1200 T2126 T2122 prep of,domain
R1201 T2127 T2128 punct ~,700
R1202 T2128 T2129 nummod 700,residues
R1203 T2129 T2126 pobj residues,of
R1204 T2130 T2129 punct (,residues
R1205 T2131 T2132 punct ~,80
R1206 T2132 T2133 nummod 80,kDa
R1207 T2133 T2129 appos kDa,residues
R1208 T2134 T2122 punct ),domain
R1209 T2135 T2122 punct ", ",domain
R1210 T2136 T2137 prep for,identified
R1211 T2137 T2122 relcl identified,domain
R1212 T2138 T2136 pobj which,for
R1213 T2139 T2140 det no,partners
R1214 T2140 T2137 nsubjpass partners,identified
R1215 T2141 T2140 amod molecular,partners
R1216 T2142 T2137 aux have,identified
R1217 T2143 T2137 auxpass been,identified
R1218 T2144 T2137 prep until,identified
R1219 T2145 T2146 det this,date
R1220 T2146 T2144 pobj date,until
R1221 T2147 T2114 punct .,is
R1222 T2149 T2150 nmod Brain,libraries
R1223 T2150 T2157 nsubjpass libraries,screened
R1224 T2151 T2149 cc and,Brain
R1225 T2152 T2149 conj retina,Brain
R1226 T2153 T2150 nmod yeast,libraries
R1227 T2154 T2155 nummod two,hybrid
R1228 T2155 T2150 compound hybrid,libraries
R1229 T2156 T2155 punct -,hybrid
R1230 T2158 T2157 auxpass were,screened
R1231 T2159 T2157 prep with,screened
R1232 T2160 T2159 pobj LD,with
R1233 T2161 T2157 punct .,screened
R1234 T2163 T2164 nsubjpass Cox11,identified
R1235 T2165 T2164 auxpass was,identified
R1236 T2166 T2164 prep as,identified
R1237 T2167 T2168 det a,partner
R1238 T2168 T2166 pobj partner,as
R1239 T2169 T2168 prep to,partner
R1240 T2170 T2171 det this,domain
R1241 T2171 T2169 pobj domain,to
R1242 T2172 T2173 punct (,1B
R1243 T2173 T2164 parataxis 1B,identified
R1244 T2174 T2173 compound Figure,1B
R1245 T2175 T2173 cc and,1B
R1246 T2176 T2173 conj 1C,1B
R1247 T2177 T2173 punct ),1B
R1248 T2178 T2164 punct .,identified
R1249 T2180 T2181 nsubj Cox11,is
R1250 T2182 T2183 det a,metallochaperone
R1251 T2183 T2181 attr metallochaperone,is
R1252 T2184 T2183 acl implicated,metallochaperone
R1253 T2185 T2184 prep in,implicated
R1254 T2186 T2187 compound cytochrome,oxidase
R1255 T2187 T2189 compound oxidase,assembly
R1256 T2188 T2187 compound c,oxidase
R1257 T2189 T2185 pobj assembly,in
R1258 T2190 T2191 punct [,31
R1259 T2191 T2181 parataxis 31,is
R1260 T2192 T2191 nummod 30,31
R1261 T2193 T2191 punct ",",31
R1262 T2194 T2191 punct ],31
R1263 T2195 T2181 punct .,is
R1264 T2197 T2198 compound Structure,function
R1265 T2198 T2200 compound function,analysis
R1266 T2199 T2198 punct -,function
R1267 T2200 T2201 nsubj analysis,showed
R1268 T2202 T2200 prep of,analysis
R1269 T2203 T2204 det the,interaction
R1270 T2204 T2202 pobj interaction,of
R1271 T2205 T2204 prep between,interaction
R1272 T2206 T2205 pobj mCox11,between
R1273 T2207 T2206 punct ", ",mCox11
R1274 T2208 T2206 conj LD,mCox11
R1275 T2209 T2208 prep of,LD
R1276 T2210 T2209 pobj RanBP2,of
R1277 T2211 T2208 punct ", ",LD
R1278 T2212 T2208 cc and,LD
R1279 T2213 T2208 conj subdomains,LD
R1280 T2214 T2213 advmod thereof,subdomains
R1281 T2215 T2200 punct ", ",analysis
R1282 T2216 T2200 prep with,analysis
R1283 T2217 T2218 amod quantitative,assays
R1284 T2218 T2216 pobj assays,with
R1285 T2219 T2218 nmod yeast,assays
R1286 T2220 T2221 nummod two,hybrid
R1287 T2221 T2218 compound hybrid,assays
R1288 T2222 T2221 punct -,hybrid
R1289 T2223 T2224 punct [,32
R1290 T2224 T2200 parataxis 32,analysis
R1291 T2225 T2224 punct ],32
R1292 T2226 T2201 punct ", ",showed
R1293 T2227 T2228 amod optimal,interaction
R1294 T2228 T2201 dobj interaction,showed
R1295 T2229 T2228 prep between,interaction
R1296 T2230 T2231 det the,proteins
R1297 T2231 T2229 pobj proteins,between
R1298 T2232 T2231 amod intact,proteins
R1299 T2233 T2231 nmod LD,proteins
R1300 T2234 T2233 cc and,LD
R1301 T2235 T2233 conj Cox11,LD
R1302 T2236 T2237 punct (,1C
R1303 T2237 T2201 parataxis 1C,showed
R1304 T2238 T2237 compound Figure,1C
R1305 T2239 T2237 punct ),1C
R1306 T2240 T2201 punct .,showed
R1307 T2242 T2243 amod Pull,assays
R1308 T2243 T2246 nsubj assays,precipitates
R1309 T2244 T2242 punct -,Pull
R1310 T2245 T2242 prt down,Pull
R1311 T2247 T2243 prep of,assays
R1312 T2248 T2249 amod retinal,extracts
R1313 T2249 T2247 pobj extracts,of
R1314 T2250 T2243 prep with,assays
R1315 T2251 T2252 nmod glutathione,transferase
R1316 T2252 T2255 nmod transferase,LD
R1317 T2253 T2252 nmod S,transferase
R1318 T2254 T2252 punct -,transferase
R1319 T2255 T2250 pobj LD,with
R1320 T2256 T2252 punct (,transferase
R1321 T2257 T2252 appos GST,transferase
R1322 T2258 T2255 punct ),LD
R1323 T2259 T2255 punct -,LD
R1324 T2260 T2261 det a,isoform
R1325 T2261 T2246 dobj isoform,precipitates
R1326 T2262 T2263 compound sodium,sulfate
R1327 T2263 T2265 npadvmod sulfate,resistant
R1328 T2264 T2263 compound dodecyl,sulfate
R1329 T2265 T2261 amod resistant,isoform
R1330 T2266 T2265 punct -,resistant
R1331 T2267 T2261 compound dimer,isoform
R1332 T2268 T2261 prep of,isoform
R1333 T2269 T2268 pobj Cox11,of
R1334 T2270 T2271 punct (,panel
R1335 T2271 T2261 parataxis panel,isoform
R1336 T2272 T2273 compound Figure,1D
R1337 T2273 T2271 dep 1D,panel
R1338 T2274 T2271 punct ", ",panel
R1339 T2275 T2271 amod top,panel
R1340 T2276 T2271 punct ),panel
R1341 T2277 T2261 punct ", ",isoform
R1342 T2278 T2279 dep which,bind
R1343 T2279 T2261 relcl bind,isoform
R1344 T2280 T2279 aux does,bind
R1345 T2281 T2279 neg not,bind
R1346 T2282 T2279 prep to,bind
R1347 T2283 T2284 compound GST,LDZIP
R1348 T2284 T2282 pobj LDZIP,to
R1349 T2285 T2284 punct -,LDZIP
R1350 T2286 T2284 advmod alone,LDZIP
R1351 T2287 T2246 punct .,precipitates
R1352 T2289 T2290 prep In,found
R1353 T2291 T2289 pobj addition,In
R1354 T2292 T2291 prep to,addition
R1355 T2293 T2292 pobj Cox11,to
R1356 T2294 T2290 punct ", ",found
R1357 T2295 T2290 nsubj we,found
R1358 T2296 T2290 advmod also,found
R1359 T2297 T2298 mark that,associated
R1360 T2298 T2290 ccomp associated,found
R1361 T2299 T2300 amod other,components
R1362 T2300 T2298 nsubj components,associated
R1363 T2301 T2300 amod mitochondrial,components
R1364 T2302 T2303 amod such,as
R1365 T2303 T2300 prep as,components
R1366 T2304 T2305 det the,protein
R1367 T2305 T2303 pobj protein,as
R1368 T2306 T2307 amod outer,membrane
R1369 T2307 T2308 npadvmod membrane,associated
R1370 T2308 T2305 amod associated,protein
R1371 T2309 T2308 punct -,associated
R1372 T2310 T2305 punct ", ",protein
R1373 T2311 T2305 appos HKI,protein
R1374 T2312 T2313 punct [,33
R1375 T2313 T2311 parataxis 33,HKI
R1376 T2314 T2313 punct ],33
R1377 T2315 T2316 punct (,panel
R1378 T2316 T2311 parataxis panel,HKI
R1379 T2317 T2318 compound Figure,1D
R1380 T2318 T2316 dep 1D,panel
R1381 T2319 T2316 punct ", ",panel
R1382 T2320 T2316 amod bottom,panel
R1383 T2321 T2316 punct ),panel
R1384 T2322 T2311 cc and,HKI
R1385 T2323 T2311 conj mHsp70,HKI
R1386 T2324 T2325 punct (,data
R1387 T2325 T2323 meta data,mHsp70
R1388 T2326 T2325 amod unpublished,data
R1389 T2327 T2325 punct ),data
R1390 T2328 T2298 punct ", ",associated
R1391 T2329 T2298 prep with,associated
R1392 T2330 T2329 pobj LD,with
R1393 T2331 T2330 prep of,LD
R1394 T2332 T2331 pobj RanBP2,of
R1395 T2333 T2290 punct .,found
R1396 T2335 T2336 det This,association
R1397 T2336 T2337 nsubj association,was
R1398 T2338 T2339 advmod highly,specific
R1399 T2339 T2337 acomp specific,was
R1400 T2340 T2339 prep toward,specific
R1401 T2341 T2342 det the,isoform
R1402 T2342 T2340 pobj isoform,toward
R1403 T2343 T2342 compound HKI,isoform
R1404 T2344 T2337 punct ", ",was
R1405 T2345 T2346 mark because,interact
R1406 T2346 T2337 advcl interact,was
R1407 T2347 T2346 nsubj HKII,interact
R1408 T2348 T2347 punct ", ",HKII
R1409 T2349 T2347 conj HKIII,HKII
R1410 T2350 T2349 punct ", ",HKIII
R1411 T2351 T2349 cc and,HKIII
R1412 T2352 T2349 conj glucokinase,HKIII
R1413 T2353 T2346 aux did,interact
R1414 T2354 T2346 neg not,interact
R1415 T2355 T2346 prep with,interact
R1416 T2356 T2357 det the,LD
R1417 T2357 T2355 pobj LD,with
R1418 T2358 T2357 prep of,LD
R1419 T2359 T2358 pobj RanBP2,of
R1420 T2360 T2361 punct (,data
R1421 T2361 T2346 meta data,interact
R1422 T2362 T2361 amod unpublished,data
R1423 T2363 T2361 punct ),data
R1424 T2364 T2337 punct .,was
R1425 T2366 T2367 det The,interaction
R1426 T2367 T2368 nsubj interaction,occurred
R1427 T2369 T2367 prep of,interaction
R1428 T2370 T2369 pobj Cox11,of
R1429 T2371 T2370 punct ", ",Cox11
R1430 T2372 T2370 conj HKI,Cox11
R1431 T2373 T2372 punct ", ",HKI
R1432 T2374 T2372 cc and,HKI
R1433 T2375 T2372 conj mHsp70,HKI
R1434 T2376 T2367 prep with,interaction
R1435 T2377 T2376 pobj RanBP2,with
R1436 T2378 T2379 advmod in,vivo
R1437 T2379 T2368 advmod vivo,occurred
R1438 T2380 T2368 prep in,occurred
R1439 T2381 T2382 amod retinal,extracts
R1440 T2382 T2380 pobj extracts,in
R1441 T2383 T2368 punct ", ",occurred
R1442 T2384 T2385 mark since,coimmunoprecipitated
R1443 T2385 T2368 advcl coimmunoprecipitated,occurred
R1444 T2386 T2385 nsubj antibodies,coimmunoprecipitated
R1445 T2387 T2386 prep against,antibodies
R1446 T2388 T2389 det these,RanBP2
R1447 T2389 T2387 pobj RanBP2,against
R1448 T2390 T2389 cc and,RanBP2
R1449 T2391 T2385 dobj RanBP2,coimmunoprecipitated
R1450 T2392 T2393 punct (,1E
R1451 T2393 T2391 parataxis 1E,RanBP2
R1452 T2394 T2393 compound Figure,1E
R1453 T2395 T2393 punct ),1E
R1454 T2396 T2391 cc and,RanBP2
R1455 T2397 T2391 conj HKI,RanBP2
R1456 T2398 T2399 punct (,1F
R1457 T2399 T2397 parataxis 1F,HKI
R1458 T2400 T2399 compound Figure,1F
R1459 T2401 T2399 punct ),1F
R1460 T2402 T2385 punct ", ",coimmunoprecipitated
R1461 T2403 T2385 advmod respectively,coimmunoprecipitated
R1462 T2404 T2385 punct ", ",coimmunoprecipitated
R1463 T2405 T2385 cc and,coimmunoprecipitated
R1464 T2406 T2407 det these,interactions
R1465 T2407 T2408 nsubjpass interactions,observed
R1466 T2408 T2385 conj observed,coimmunoprecipitated
R1467 T2409 T2408 auxpass were,observed
R1468 T2410 T2408 prep across,observed
R1469 T2411 T2412 amod different,tissues
R1470 T2412 T2410 pobj tissues,across
R1471 T2413 T2414 punct (,S1
R1472 T2414 T2408 parataxis S1,observed
R1473 T2415 T2414 compound Figure,S1
R1474 T2416 T2414 punct ),S1
R1475 T2417 T2368 punct .,occurred
R1476 T2419 T2420 mark Since,exhibits
R1477 T2420 T2422 advcl exhibits,assessed
R1478 T2421 T2420 nsubj RanBP2,exhibits
R1479 T2423 T2424 compound chaperone,activity
R1480 T2424 T2420 dobj activity,exhibits
R1481 T2425 T2422 punct ", ",assessed
R1482 T2426 T2422 nsubj we,assessed
R1483 T2427 T2428 mark whether,was
R1484 T2428 T2422 ccomp was,assessed
R1485 T2429 T2430 det the,interaction
R1486 T2430 T2428 nsubj interaction,was
R1487 T2431 T2430 prep between,interaction
R1488 T2432 T2433 det the,LD
R1489 T2433 T2431 pobj LD,between
R1490 T2434 T2433 prep of,LD
R1491 T2435 T2434 pobj RanBP2,of
R1492 T2436 T2433 cc and,LD
R1493 T2437 T2433 conj Cox11,LD
R1494 T2438 T2428 acomp direct,was
R1495 T2439 T2440 cc and,activity
R1496 T2440 T2428 dep activity,was
R1497 T2441 T2440 det the,activity
R1498 T2442 T2440 compound chaperone,activity
R1499 T2443 T2440 prep of,activity
R1500 T2444 T2443 pobj LD,of
R1501 T2445 T2440 prep toward,activity
R1502 T2446 T2447 amod folding,species
R1503 T2447 T2445 pobj species,toward
R1504 T2448 T2447 prep of,species
R1505 T2449 T2448 pobj Cox11,of
R1506 T2450 T2422 punct .,assessed
R1507 T2452 T2453 compound Reconstitution,binding
R1508 T2453 T2454 compound binding,assays
R1509 T2454 T2455 nsubjpass assays,carried
R1510 T2456 T2455 auxpass were,carried
R1511 T2457 T2455 prt out,carried
R1512 T2458 T2455 prep between,carried
R1513 T2459 T2460 amod purified,LD
R1514 T2460 T2458 pobj LD,between
R1515 T2461 T2460 cc and,LD
R1516 T2462 T2460 conj Cox11,LD
R1517 T2463 T2462 punct ", ",Cox11
R1518 T2464 T2465 advmod fully,denatured
R1519 T2465 T2462 acl denatured,Cox11
R1520 T2466 T2464 cc and,fully
R1521 T2467 T2464 conj partially,fully
R1522 T2468 T2465 prep with,denatured
R1523 T2469 T2468 pobj GnHCl,with
R1524 T2470 T2469 cc and,GnHCl
R1525 T2471 T2469 conj urea,GnHCl
R1526 T2472 T2465 punct ", ",denatured
R1527 T2473 T2465 advmod respectively,denatured
R1528 T2474 T2462 punct ", ",Cox11
R1529 T2475 T2462 cc and,Cox11
R1530 T2476 T2477 amod native,Cox11
R1531 T2477 T2462 conj Cox11,Cox11
R1532 T2478 T2479 punct (,1G
R1533 T2479 T2477 parataxis 1G,Cox11
R1534 T2480 T2479 compound Figure,1G
R1535 T2481 T2479 cc and,1G
R1536 T2482 T2479 conj 1H,1G
R1537 T2483 T2479 punct ),1G
R1538 T2484 T2455 punct .,carried
R1539 T2486 T2487 amod Partial,denatured
R1540 T2487 T2488 amod denatured,Cox11
R1541 T2488 T2489 nsubj Cox11,exhibits
R1542 T2490 T2491 advmod significantly,higher
R1543 T2491 T2492 amod higher,affinity
R1544 T2492 T2489 dobj affinity,exhibits
R1545 T2493 T2491 cc and,higher
R1546 T2494 T2495 npadvmod concentration,dependent
R1547 T2495 T2491 conj dependent,higher
R1548 T2496 T2495 punct -,dependent
R1549 T2497 T2492 compound binding,affinity
R1550 T2498 T2492 prep toward,affinity
R1551 T2499 T2498 pobj LD,toward
R1552 T2500 T2489 prep compared,exhibits
R1553 T2501 T2500 prep with,compared
R1554 T2502 T2503 det the,Cox11
R1555 T2503 T2501 pobj Cox11,with
R1556 T2504 T2503 amod native,Cox11
R1557 T2505 T2504 cc and,native
R1558 T2506 T2507 advmod fully,denatured
R1559 T2507 T2504 conj denatured,native
R1560 T2508 T2509 punct (,1G
R1561 T2509 T2489 parataxis 1G,exhibits
R1562 T2510 T2509 compound Figure,1G
R1563 T2511 T2509 punct ),1G
R1564 T2512 T2489 punct .,exhibits
R1565 T2514 T2515 prep In,shows
R1566 T2516 T2514 pobj addition,In
R1567 T2517 T2515 punct ", ",shows
R1568 T2518 T2519 amod native,Cox11
R1569 T2519 T2515 nsubj Cox11,shows
R1570 T2520 T2519 acl purified,Cox11
R1571 T2521 T2520 prep upon,purified
R1572 T2522 T2521 pobj expression,upon
R1573 T2523 T2520 prep in,purified
R1574 T2524 T2525 det the,presence
R1575 T2525 T2523 pobj presence,in
R1576 T2526 T2525 prep of,presence
R1577 T2527 T2526 pobj CuSO4,of
R1578 T2528 T2527 punct (,CuSO4
R1579 T2529 T2530 det a,group
R1580 T2530 T2527 appos group,CuSO4
R1581 T2531 T2530 amod prosthetic,group
R1582 T2532 T2533 advmod tightly,bound
R1583 T2533 T2530 acl bound,group
R1584 T2534 T2533 prep to,bound
R1585 T2535 T2534 pobj Cox11,to
R1586 T2536 T2520 punct ),purified
R1587 T2537 T2538 punct [,31
R1588 T2538 T2520 parataxis 31,purified
R1589 T2539 T2538 punct ],31
R1590 T2540 T2515 punct ", ",shows
R1591 T2541 T2542 advmod significantly,higher
R1592 T2542 T2543 amod higher,activity
R1593 T2543 T2515 dobj activity,shows
R1594 T2544 T2543 compound binding,activity
R1595 T2545 T2543 prep toward,activity
R1596 T2546 T2547 det the,LD
R1597 T2547 T2545 pobj LD,toward
R1598 T2548 T2547 prep of,LD
R1599 T2549 T2548 pobj RanBP2,of
R1600 T2550 T2543 punct ", ",activity
R1601 T2551 T2543 prep than,activity
R1602 T2552 T2551 prep in,than
R1603 T2553 T2554 det the,absence
R1604 T2554 T2552 pobj absence,in
R1605 T2555 T2554 prep of,absence
R1606 T2556 T2555 pobj CuSO4,of
R1607 T2557 T2558 punct (,1H
R1608 T2558 T2515 parataxis 1H,shows
R1609 T2559 T2558 compound Figure,1H
R1610 T2560 T2558 punct ),1H
R1611 T2561 T2515 punct .,shows
R1612 T2637 T2638 nsubj Cox,Inhibits
R1613 T2639 T2637 nummod 11,Cox
R1614 T2640 T2641 compound HKI,Activity
R1615 T2641 T2638 dobj Activity,Inhibits
R1616 T2642 T2641 cc and,Activity
R1617 T2643 T2644 det the,LD
R1618 T2644 T2641 conj LD,Activity
R1619 T2645 T2644 prep of,LD
R1620 T2646 T2645 pobj RanBP2,of
R1621 T2647 T2638 dep Reverses,Inhibits
R1622 T2648 T2649 det the,Inhibition
R1623 T2649 T2647 dobj Inhibition,Reverses
R1624 T2650 T2649 prep of,Inhibition
R1625 T2651 T2650 pobj Cox11,of
R1626 T2652 T2649 prep over,Inhibition
R1627 T2653 T2652 pobj HKI,over
R1628 T2655 T2656 aux To,probe
R1629 T2656 T2657 advcl probe,examined
R1630 T2658 T2659 mark whether,modulates
R1631 T2659 T2656 ccomp modulates,probe
R1632 T2660 T2661 det the,interaction
R1633 T2661 T2659 nsubj interaction,modulates
R1634 T2662 T2661 prep of,interaction
R1635 T2663 T2662 pobj Cox11,of
R1636 T2664 T2663 cc and,Cox11
R1637 T2665 T2663 conj HKI,Cox11
R1638 T2666 T2661 prep with,interaction
R1639 T2667 T2668 det the,LD
R1640 T2668 T2666 pobj LD,with
R1641 T2669 T2668 prep of,LD
R1642 T2670 T2669 pobj RanBP2,of
R1643 T2671 T2672 det the,activity
R1644 T2672 T2659 dobj activity,modulates
R1645 T2673 T2672 amod enzymatic,activity
R1646 T2674 T2672 prep of,activity
R1647 T2675 T2674 pobj HKI,of
R1648 T2676 T2657 punct ", ",examined
R1649 T2677 T2657 nsubj we,examined
R1650 T2678 T2657 advmod first,examined
R1651 T2679 T2680 det the,effect
R1652 T2680 T2657 dobj effect,examined
R1653 T2681 T2680 prep of,effect
R1654 T2682 T2681 pcomp increasing,of
R1655 T2683 T2682 dobj concentrations,increasing
R1656 T2684 T2683 prep of,concentrations
R1657 T2685 T2684 pobj Cox11,of
R1658 T2686 T2680 prep on,effect
R1659 T2687 T2688 det the,rates
R1660 T2688 T2686 pobj rates,on
R1661 T2689 T2688 amod initial,rates
R1662 T2690 T2688 prep of,rates
R1663 T2691 T2692 nmod HKI,activity
R1664 T2692 T2690 pobj activity,of
R1665 T2693 T2692 amod enzymatic,activity
R1666 T2694 T2695 punct (,2A
R1667 T2695 T2657 parataxis 2A,examined
R1668 T2696 T2695 compound Figure,2A
R1669 T2697 T2695 punct ),2A
R1670 T2698 T2657 punct .,examined
R1671 T2700 T2701 nsubj Cox11,inhibits
R1672 T2702 T2701 advmod strongly,inhibits
R1673 T2703 T2704 compound HKI,activity
R1674 T2704 T2701 dobj activity,inhibits
R1675 T2705 T2701 prep in,inhibits
R1676 T2706 T2707 det a,fashion
R1677 T2707 T2705 pobj fashion,in
R1678 T2708 T2709 npadvmod concentration,dependent
R1679 T2709 T2707 amod dependent,fashion
R1680 T2710 T2709 punct -,dependent
R1681 T2711 T2701 punct ", ",inhibits
R1682 T2712 T2701 cc and,inhibits
R1683 T2713 T2714 prep at,recorded
R1684 T2714 T2701 conj recorded,inhibits
R1685 T2715 T2716 punct ~,15
R1686 T2716 T2717 nummod 15,nM
R1687 T2717 T2713 pobj nM,at
R1688 T2718 T2717 prep of,nM
R1689 T2719 T2718 pobj Cox11,of
R1690 T2720 T2714 punct ", ",recorded
R1691 T2721 T2722 compound HKI,activity
R1692 T2722 T2714 nsubjpass activity,recorded
R1693 T2723 T2714 aux could,recorded
R1694 T2724 T2714 neg not,recorded
R1695 T2725 T2714 auxpass be,recorded
R1696 T2726 T2727 punct (,2A
R1697 T2727 T2714 parataxis 2A,recorded
R1698 T2728 T2727 compound Figure,2A
R1699 T2729 T2727 punct ),2A
R1700 T2730 T2714 punct .,recorded
R1701 T2732 T2733 nsubj Cox11,behaves
R1702 T2734 T2733 prep as,behaves
R1703 T2735 T2736 det a,inhibitor
R1704 T2736 T2734 pobj inhibitor,as
R1705 T2737 T2736 amod partial,inhibitor
R1706 T2738 T2736 amod noncompetitive,inhibitor
R1707 T2739 T2736 prep of,inhibitor
R1708 T2740 T2739 pobj HKI,of
R1709 T2741 T2733 prep by,behaves
R1710 T2742 T2741 pcomp affecting,by
R1711 T2743 T2744 det the,V max
R1712 T2744 T2742 dobj V max,affecting
R1713 T2745 T2744 prep of,V max
R1714 T2746 T2745 pobj HKI,of
R1715 T2747 T2744 prep for,V max
R1716 T2748 T2747 pobj glucose,for
R1717 T2749 T2750 punct (,2B
R1718 T2750 T2742 parataxis 2B,affecting
R1719 T2751 T2750 compound Figure,2B
R1720 T2752 T2750 punct ),2B
R1721 T2753 T2733 punct .,behaves
R1722 T2755 T2756 advmod Then,evaluated
R1723 T2757 T2756 punct ", ",evaluated
R1724 T2758 T2756 nsubj we,evaluated
R1725 T2759 T2760 det the,effect
R1726 T2760 T2756 dobj effect,evaluated
R1727 T2761 T2760 prep of,effect
R1728 T2762 T2763 det the,LD
R1729 T2763 T2761 pobj LD,of
R1730 T2764 T2763 prep of,LD
R1731 T2765 T2764 pobj RanBP2,of
R1732 T2766 T2760 prep on,effect
R1733 T2767 T2768 det the,activity
R1734 T2768 T2766 pobj activity,on
R1735 T2769 T2768 compound HK,activity
R1736 T2770 T2756 prep in,evaluated
R1737 T2771 T2772 det the,presence
R1738 T2772 T2770 pobj presence,in
R1739 T2773 T2772 prep of,presence
R1740 T2774 T2775 det a,concentration
R1741 T2775 T2773 pobj concentration,of
R1742 T2776 T2775 amod fixed,concentration
R1743 T2777 T2775 amod inhibitory,concentration
R1744 T2778 T2775 prep of,concentration
R1745 T2779 T2778 pobj Cox11,of
R1746 T2780 T2775 punct ", ",concentration
R1747 T2781 T2782 amod saturating,concentration
R1748 T2782 T2775 conj concentration,concentration
R1749 T2783 T2782 prep of,concentration
R1750 T2784 T2785 compound glucose,substrate
R1751 T2785 T2783 pobj substrate,of
R1752 T2786 T2782 punct ", ",concentration
R1753 T2787 T2782 cc and,concentration
R1754 T2788 T2789 amod increasing,concentrations
R1755 T2789 T2782 conj concentrations,concentration
R1756 T2790 T2789 prep of,concentrations
R1757 T2791 T2790 pobj LD,of
R1758 T2792 T2756 punct .,evaluated
R1759 T2794 T2795 mark As,shown
R1760 T2795 T2796 advcl shown,reversed
R1761 T2797 T2795 prep in,shown
R1762 T2798 T2799 compound Figure,2C
R1763 T2799 T2797 pobj 2C,in
R1764 T2800 T2796 punct ", ",reversed
R1765 T2801 T2802 det the,domain
R1766 T2802 T2796 nsubj domain,reversed
R1767 T2803 T2802 compound LD,domain
R1768 T2804 T2796 advmod sharply,reversed
R1769 T2805 T2806 det the,effect
R1770 T2806 T2796 dobj effect,reversed
R1771 T2807 T2806 amod inhibitory,effect
R1772 T2808 T2806 prep of,effect
R1773 T2809 T2808 pobj Cox11,of
R1774 T2810 T2806 prep on,effect
R1775 T2811 T2812 compound HKI,activity
R1776 T2812 T2810 pobj activity,on
R1777 T2813 T2796 prep in,reversed
R1778 T2814 T2815 det a,manner
R1779 T2815 T2813 pobj manner,in
R1780 T2816 T2817 npadvmod concentration,dependent
R1781 T2817 T2815 amod dependent,manner
R1782 T2818 T2817 punct -,dependent
R1783 T2819 T2796 punct ", ",reversed
R1784 T2820 T2796 cc but,reversed
R1785 T2821 T2822 prep under,reach
R1786 T2822 T2796 conj reach,reversed
R1787 T2823 T2824 amod saturating,amounts
R1788 T2824 T2821 pobj amounts,under
R1789 T2825 T2823 punct (,saturating
R1790 T2826 T2823 cc and,saturating
R1791 T2827 T2823 conj stochiometric,saturating
R1792 T2828 T2824 punct ),amounts
R1793 T2829 T2824 prep of,amounts
R1794 T2830 T2829 pobj LD,of
R1795 T2831 T2822 punct ", ",reach
R1796 T2832 T2833 det the,velocity
R1797 T2833 T2822 nsubj velocity,reach
R1798 T2834 T2833 prep of,velocity
R1799 T2835 T2836 det the,reaction
R1800 T2836 T2834 pobj reaction,of
R1801 T2837 T2822 aux did,reach
R1802 T2838 T2822 neg not,reach
R1803 T2839 T2822 dobj that,reach
R1804 T2840 T2839 acl observed,that
R1805 T2841 T2840 prep for,observed
R1806 T2842 T2843 compound HKI,activity
R1807 T2843 T2841 pobj activity,for
R1808 T2844 T2840 prep in,observed
R1809 T2845 T2846 det the,absence
R1810 T2846 T2844 pobj absence,in
R1811 T2847 T2846 prep of,absence
R1812 T2848 T2847 pobj Cox11,of
R1813 T2849 T2850 punct (,2A
R1814 T2850 T2840 parataxis 2A,observed
R1815 T2851 T2850 compound Figure,2A
R1816 T2852 T2850 punct ),2A
R1817 T2853 T2822 punct ", ",reach
R1818 T2854 T2822 advcl suggesting,reach
R1819 T2855 T2856 det the,LD
R1820 T2856 T2857 nsubj LD,have
R1821 T2857 T2854 advcl have,suggesting
R1822 T2858 T2857 prep by,have
R1823 T2859 T2858 pobj itself,by
R1824 T2860 T2857 aux may,have
R1825 T2861 T2857 advmod also,have
R1826 T2862 T2863 det an,effect
R1827 T2863 T2857 dobj effect,have
R1828 T2864 T2863 prep on,effect
R1829 T2865 T2866 compound HKI,activity
R1830 T2866 T2864 pobj activity,on
R1831 T2867 T2822 punct .,reach
R1832 T2869 T2870 advmod Indeed,reduced
R1833 T2871 T2870 punct ", ",reduced
R1834 T2872 T2873 det a,concentration
R1835 T2873 T2870 nsubj concentration,reduced
R1836 T2874 T2873 compound saturating,concentration
R1837 T2875 T2873 prep of,concentration
R1838 T2876 T2875 pobj LD,of
R1839 T2877 T2878 det the,V max
R1840 T2878 T2870 dobj V max,reduced
R1841 T2879 T2878 cc but,V max
R1842 T2880 T2879 neg not,but
R1843 T2881 T2882 det the,K m
R1844 T2882 T2878 conj K m,V max
R1845 T2883 T2878 prep of,V max
R1846 T2884 T2883 pobj HKI,of
R1847 T2885 T2886 punct (,2D
R1848 T2886 T2878 parataxis 2D,V max
R1849 T2887 T2886 compound Figure,2D
R1850 T2888 T2886 punct ),2D
R1851 T2889 T2870 prep by,reduced
R1852 T2890 T2891 punct ~,20
R1853 T2891 T2892 nummod 20,%
R1854 T2892 T2889 pobj %,by
R1855 T2893 T2870 prep under,reduced
R1856 T2894 T2895 amod similar,conditions
R1857 T2895 T2893 pobj conditions,under
R1858 T2896 T2870 punct .,reduced
R1865 T2996 T2997 nsubj RanBP2,Colocalizes
R1866 T2998 T2997 prep with,Colocalizes
R1867 T2999 T2998 pobj HK1,with
R1868 T3000 T2999 punct ", ",HK1
R1869 T3001 T2999 conj Cox11,HK1
R1870 T3002 T3001 punct ", ",Cox11
R1871 T3003 T3001 cc and,Cox11
R1872 T3004 T3001 conj mHsp70,Cox11
R1873 T3005 T2997 prep in,Colocalizes
R1874 T3006 T3007 det the,Retina
R1875 T3007 T3005 pobj Retina,in
R1876 T3008 T3007 cc and,Retina
R1877 T3009 T3010 amod Cultured,Neurons
R1878 T3010 T3007 conj Neurons,Retina
R1879 T3012 T3013 prep In,shown
R1880 T3014 T3012 pobj addition,In
R1881 T3015 T3014 prep to,addition
R1882 T3016 T3017 poss its,presence
R1883 T3017 T3015 pobj presence,to
R1884 T3018 T3017 prep at,presence
R1885 T3019 T3020 det the,vicinity
R1886 T3020 T3018 pobj vicinity,at
R1887 T3021 T3020 prep of,vicinity
R1888 T3022 T3021 pobj NPCs,of
R1889 T3023 T3013 punct ", ",shown
R1890 T3024 T3013 nsubj we,shown
R1891 T3025 T3013 aux have,shown
R1892 T3026 T3013 advmod previously,shown
R1893 T3027 T3028 mark that,is
R1894 T3028 T3013 ccomp is,shown
R1895 T3029 T3028 nsubj RanBP2,is
R1896 T3030 T3028 dep localized,is
R1897 T3031 T3030 prep to,localized
R1898 T3032 T3030 cc and,localized
R1899 T3033 T3034 amod abundant,compartment
R1900 T3034 T3030 conj compartment,localized
R1901 T3035 T3033 prep in,abundant
R1902 T3036 T3034 det the,compartment
R1903 T3037 T3038 npadvmod mitochondria,rich
R1904 T3038 T3034 amod rich,compartment
R1905 T3039 T3038 punct -,rich
R1906 T3040 T3034 amod ellipsoid,compartment
R1907 T3041 T3034 amod subcellular,compartment
R1908 T3042 T3034 prep of,compartment
R1909 T3043 T3044 amod photosensory,neurons
R1910 T3044 T3042 pobj neurons,of
R1911 T3045 T3046 punct (,photoreceptor
R1912 T3046 T3043 parataxis photoreceptor,photosensory
R1913 T3047 T3046 punct ),photoreceptor
R1914 T3048 T3044 prep of,neurons
R1915 T3049 T3050 det the,retina
R1916 T3050 T3048 pobj retina,of
R1917 T3051 T3052 punct [,19
R1918 T3052 T3028 parataxis 19,is
R1919 T3053 T3052 punct ],19
R1920 T3054 T3013 punct .,shown
R1921 T3056 T3057 nsubj We,extended
R1922 T3058 T3059 det the,studies
R1923 T3059 T3057 dobj studies,extended
R1924 T3060 T3059 amod subcellular,studies
R1925 T3061 T3059 compound colocalization,studies
R1926 T3062 T3059 prep on,studies
R1927 T3063 T3062 pobj RanBP2,on
R1928 T3064 T3063 cc and,RanBP2
R1929 T3065 T3066 poss its,partners
R1930 T3066 T3063 conj partners,RanBP2
R1931 T3067 T3066 amod novel,partners
R1932 T3068 T3057 prep by,extended
R1933 T3069 T3068 pobj immunocytochemistry,by
R1934 T3070 T3071 aux to,determine
R1935 T3071 T3057 advcl determine,extended
R1936 T3072 T3073 mark if,colocalize
R1937 T3073 T3071 ccomp colocalize,determine
R1938 T3074 T3073 nsubj RanBP2,colocalize
R1939 T3075 T3074 punct ", ",RanBP2
R1940 T3076 T3074 conj Cox11,RanBP2
R1941 T3077 T3076 punct ", ",Cox11
R1942 T3078 T3076 conj HKI,Cox11
R1943 T3079 T3078 punct ", ",HKI
R1944 T3080 T3078 cc and,HKI
R1945 T3081 T3078 conj mHsp70,HKI
R1946 T3082 T3073 prep in,colocalize
R1947 T3083 T3084 amod hippocampal,neurons
R1948 T3084 T3082 pobj neurons,in
R1949 T3085 T3086 punct (,3A
R1950 T3086 T3084 parataxis 3A,neurons
R1951 T3087 T3086 compound Figure,3A
R1952 T3088 T3089 punct –,3C
R1953 T3089 T3086 prep 3C,3A
R1954 T3090 T3086 punct ),3A
R1955 T3091 T3084 punct ", ",neurons
R1956 T3092 T3093 amod cerebral,cortex
R1957 T3093 T3094 compound cortex,neurons
R1958 T3094 T3084 conj neurons,neurons
R1959 T3095 T3096 punct (,3D
R1960 T3096 T3094 parataxis 3D,neurons
R1961 T3097 T3096 compound Figure,3D
R1962 T3098 T3099 punct –,3F
R1963 T3099 T3096 prep 3F,3D
R1964 T3100 T3096 punct ),3D
R1965 T3101 T3094 punct ", ",neurons
R1966 T3102 T3103 amod ellipsoid,compartments
R1967 T3103 T3094 conj compartments,neurons
R1968 T3104 T3103 punct (,compartments
R1969 T3105 T3106 npadvmod mitochondria,rich
R1970 T3106 T3103 amod rich,compartments
R1971 T3107 T3106 punct -,rich
R1972 T3108 T3103 punct ),compartments
R1973 T3109 T3103 amod subcellular,compartments
R1974 T3110 T3103 prep of,compartments
R1975 T3111 T3112 amod photosensory,neurons
R1976 T3112 T3110 pobj neurons,of
R1977 T3113 T3112 prep of,neurons
R1978 T3114 T3115 det the,retina
R1979 T3115 T3113 pobj retina,of
R1980 T3116 T3117 punct (,3G
R1981 T3117 T3115 parataxis 3G,retina
R1982 T3118 T3117 compound Figure,3G
R1983 T3119 T3120 punct –,3O
R1984 T3120 T3117 prep 3O,3G
R1985 T3121 T3117 punct ),3G
R1986 T3122 T3103 punct ", ",compartments
R1987 T3123 T3103 cc and,compartments
R1988 T3124 T3125 amod dissociated,glia
R1989 T3125 T3103 conj glia,compartments
R1990 T3126 T3125 amod primary,glia
R1991 T3127 T3125 cc and,glia
R1992 T3128 T3129 compound neuron,cultures
R1993 T3129 T3125 conj cultures,glia
R1994 T3130 T3125 prep from,glia
R1995 T3131 T3132 det the,brain
R1996 T3132 T3130 pobj brain,from
R1997 T3133 T3134 punct (,3P
R1998 T3134 T3125 parataxis 3P,glia
R1999 T3135 T3134 compound Figure,3P
R2000 T3136 T3137 punct –,3Z
R2001 T3137 T3134 prep 3Z,3P
R2002 T3138 T3134 punct ),3P
R2003 T3139 T3057 punct .,extended
R2004 T3141 T3142 amod Double,immunostaining
R2005 T3142 T3143 nsubj immunostaining,showed
R2006 T3144 T3142 prep with,immunostaining
R2007 T3145 T3144 pobj antibodies,with
R2008 T3146 T3145 prep against,antibodies
R2009 T3147 T3148 det these,proteins
R2010 T3148 T3146 pobj proteins,against
R2011 T3149 T3150 mark that,colocalize
R2012 T3150 T3143 ccomp colocalize,showed
R2013 T3151 T3150 nsubj they,colocalize
R2014 T3152 T3150 prep to,colocalize
R2015 T3153 T3154 det the,mitochondria
R2016 T3154 T3152 pobj mitochondria,to
R2017 T3155 T3156 punct (,3A
R2018 T3156 T3150 parataxis 3A,colocalize
R2019 T3157 T3156 compound Figure,3A
R2020 T3158 T3159 punct –,3Z
R2021 T3159 T3156 prep 3Z,3A
R2022 T3160 T3156 punct ),3A
R2023 T3161 T3143 punct .,showed
R2028 T3449 T3450 nsubj Haploinsufficiency,Causes
R2029 T3451 T3449 prep of,Haploinsufficiency
R2030 T3452 T3451 pobj RanBP2,of
R2031 T3453 T3454 amod Decreased,Levels
R2032 T3454 T3450 dobj Levels,Causes
R2033 T3455 T3454 prep of,Levels
R2034 T3456 T3455 pobj HKI,of
R2035 T3457 T3454 cc and,Levels
R2036 T3458 T3459 amod Partial,Mislocalization
R2037 T3459 T3454 conj Mislocalization,Levels
R2038 T3460 T3459 prep of,Mislocalization
R2039 T3461 T3460 pobj HKI,of
R2040 T3463 T3464 aux To,determine
R2041 T3464 T3465 advcl determine,employed
R2042 T3466 T3467 det the,implications
R2043 T3467 T3464 dobj implications,determine
R2044 T3468 T3467 amod physiological,implications
R2045 T3469 T3467 prep of,implications
R2046 T3470 T3471 det the,interaction
R2047 T3471 T3469 pobj interaction,of
R2048 T3472 T3471 prep between,interaction
R2049 T3473 T3472 pobj RanBP2,between
R2050 T3474 T3473 cc and,RanBP2
R2051 T3475 T3473 conj HKI,RanBP2
R2052 T3476 T3475 punct (,HKI
R2053 T3477 T3475 cc and,HKI
R2054 T3478 T3479 amod other,partners
R2055 T3479 T3475 conj partners,HKI
R2056 T3480 T3465 punct ),employed
R2057 T3481 T3465 punct ", ",employed
R2058 T3482 T3465 nsubj we,employed
R2059 T3483 T3484 det a,line
R2060 T3484 T3465 dobj line,employed
R2061 T3485 T3484 amod murine,line
R2062 T3486 T3487 amod embryonic,stem
R2063 T3487 T3484 compound stem,line
R2064 T3488 T3484 compound 129Ola,line
R2065 T3489 T3484 compound cell,line
R2066 T3490 T3484 prep with,line
R2067 T3491 T3492 det a,locus
R2068 T3492 T3490 pobj locus,with
R2069 T3493 T3492 amod targeted,locus
R2070 T3494 T3492 compound RanBP2,locus
R2071 T3495 T3492 acl produced,locus
R2072 T3496 T3495 agent by,produced
R2073 T3497 T3498 compound gene,trapping
R2074 T3498 T3496 pobj trapping,by
R2075 T3499 T3498 punct -,trapping
R2076 T3500 T3501 aux to,produce
R2077 T3501 T3495 advcl produce,produced
R2078 T3502 T3503 amod stable,lines
R2079 T3503 T3501 dobj lines,produce
R2080 T3504 T3503 amod inbred,lines
R2081 T3505 T3506 punct (,coisogenic
R2082 T3506 T3504 parataxis coisogenic,inbred
R2083 T3507 T3506 punct ),coisogenic
R2084 T3508 T3504 cc and,inbred
R2085 T3509 T3510 amod mixed,background
R2086 T3510 T3504 conj background,inbred
R2087 T3511 T3501 punct ", ",produce
R2088 T3512 T3501 advmod respectively,produce
R2089 T3513 T3514 punct (,4A
R2090 T3514 T3465 parataxis 4A,employed
R2091 T3515 T3514 compound Figure,4A
R2092 T3516 T3514 cc and,4A
R2093 T3517 T3514 conj 4B,4A
R2094 T3518 T3514 punct ),4A
R2095 T3519 T3465 punct .,employed
R2096 T3521 T3522 nsubj Genotyping,revealed
R2097 T3523 T3521 prep of,Genotyping
R2098 T3524 T3525 nummod 299,F2
R2099 T3525 T3526 compound F2,offspring
R2100 T3526 T3523 pobj offspring,of
R2101 T3527 T3528 det a,distribution
R2102 T3528 T3522 dobj distribution,revealed
R2103 T3529 T3528 nmod RanBP2,distribution
R2104 T3530 T3529 punct +,RanBP2
R2105 T3531 T3529 punct /,RanBP2
R2106 T3532 T3529 punct +,RanBP2
R2107 T3533 T3529 punct :,RanBP2
R2108 T3534 T3529 appos RanBP2,RanBP2
R2109 T3535 T3534 punct +,RanBP2
R2110 T3536 T3534 punct /,RanBP2
R2111 T3537 T3534 punct −,RanBP2
R2112 T3538 T3529 punct :,RanBP2
R2113 T3539 T3529 appos RanBP2,RanBP2
R2114 T3540 T3539 punct −,RanBP2
R2115 T3541 T3539 punct /,RanBP2
R2116 T3542 T3539 punct −,RanBP2
R2117 T3543 T3528 punct (,distribution
R2118 T3544 T3545 nummod 89,0
R2119 T3545 T3528 appos 0,distribution
R2120 T3546 T3545 punct :,0
R2121 T3547 T3545 nummod 210,0
R2122 T3548 T3545 punct :,0
R2123 T3549 T3528 punct ),distribution
R2124 T3550 T3551 dep that,deviated
R2125 T3551 T3528 relcl deviated,distribution
R2126 T3552 T3551 prep from,deviated
R2127 T3553 T3554 det the,ratio
R2128 T3554 T3552 pobj ratio,from
R2129 T3555 T3554 amod expected,ratio
R2130 T3556 T3554 amod Mendelian,ratio
R2131 T3557 T3551 cc and,deviated
R2132 T3558 T3551 conj supports,deviated
R2133 T3559 T3560 mark that,were
R2134 T3560 T3558 ccomp were,supports
R2135 T3561 T3562 det the,mice
R2136 T3562 T3560 nsubj mice,were
R2137 T3563 T3562 nmod RanBP2,mice
R2138 T3564 T3563 punct −,RanBP2
R2139 T3565 T3563 punct /,RanBP2
R2140 T3566 T3563 punct −,RanBP2
R2141 T3567 T3568 advmod embryonically,lethal
R2142 T3568 T3560 acomp lethal,were
R2143 T3569 T3522 punct .,revealed
R2144 T3571 T3572 compound E12.5,embryos
R2145 T3572 T3573 nsubj embryos,show
R2146 T3574 T3575 amod strong,expression
R2147 T3575 T3573 dobj expression,show
R2148 T3576 T3575 prep of,expression
R2149 T3577 T3576 pobj RanBP2,of
R2150 T3578 T3575 prep in,expression
R2151 T3579 T3580 det the,vesicle
R2152 T3580 T3578 pobj vesicle,in
R2153 T3581 T3580 amod optic,vesicle
R2154 T3582 T3578 cc and,in
R2155 T3583 T3578 conj throughout,in
R2156 T3584 T3583 pobj much,throughout
R2157 T3585 T3584 prep of,much
R2158 T3586 T3587 det the,embryo
R2159 T3587 T3585 pobj embryo,of
R2160 T3588 T3587 punct ", ",embryo
R2161 T3589 T3590 dep which,had
R2162 T3590 T3587 relcl had,embryo
R2163 T3591 T3592 det no,abnormalities
R2164 T3592 T3590 dobj abnormalities,had
R2165 T3593 T3592 amod apparent,abnormalities
R2166 T3594 T3592 amod developmental,abnormalities
R2167 T3595 T3596 punct (,4C
R2168 T3596 T3573 parataxis 4C,show
R2169 T3597 T3596 compound Figure,4C
R2170 T3598 T3596 punct ),4C
R2171 T3599 T3573 punct .,show
R2172 T3601 T3602 prep In,expressed
R2173 T3603 T3601 pobj agreement,In
R2174 T3604 T3603 prep with,agreement
R2175 T3605 T3606 amod previous,analysis
R2176 T3606 T3604 pobj analysis,with
R2177 T3607 T3606 compound immunocytochemistry,analysis
R2178 T3608 T3609 punct [,19
R2179 T3609 T3606 parataxis 19,analysis
R2180 T3610 T3609 punct ],19
R2181 T3611 T3602 punct ", ",expressed
R2182 T3612 T3613 det the,gene
R2183 T3613 T3602 nsubjpass gene,expressed
R2184 T3614 T3613 compound RanBP2,gene
R2185 T3615 T3602 auxpass is,expressed
R2186 T3616 T3602 prep across,expressed
R2187 T3617 T3618 amod mature,neurons
R2188 T3618 T3616 pobj neurons,across
R2189 T3619 T3618 amod retinal,neurons
R2190 T3620 T3602 punct ", ",expressed
R2191 T3621 T3602 cc but,expressed
R2192 T3622 T3623 nsubj expression,was
R2193 T3623 T3602 conj was,expressed
R2194 T3624 T3622 prep in,expression
R2195 T3625 T3626 compound ganglion,cells
R2196 T3626 T3624 pobj cells,in
R2197 T3627 T3626 prep of,cells
R2198 T3628 T3629 det the,retina
R2199 T3629 T3627 pobj retina,of
R2200 T3630 T3629 amod adult,retina
R2201 T3631 T3632 advmod extremely,strong
R2202 T3632 T3623 acomp strong,was
R2203 T3633 T3634 punct (,4D
R2204 T3634 T3623 parataxis 4D,was
R2205 T3635 T3634 compound Figure,4D
R2206 T3636 T3634 cc and,4D
R2207 T3637 T3634 conj 4E,4D
R2208 T3638 T3634 punct ),4D
R2209 T3639 T3623 punct .,was
R2210 T3641 T3642 prep In,probed
R2211 T3643 T3641 pobj light,In
R2212 T3644 T3643 prep of,light
R2213 T3645 T3646 det the,association
R2214 T3646 T3644 pobj association,of
R2215 T3647 T3648 advmod in,vivo
R2216 T3648 T3646 advmod vivo,association
R2217 T3649 T3646 prep of,association
R2218 T3650 T3649 pobj RanBP2,of
R2219 T3651 T3646 prep with,association
R2220 T3652 T3651 pobj Cox11,with
R2221 T3653 T3652 cc and,Cox11
R2222 T3654 T3652 conj HKI,Cox11
R2223 T3655 T3656 punct (,1
R2224 T3656 T3646 parataxis 1,association
R2225 T3657 T3656 nmod Figures,1
R2226 T3658 T3656 cc and,1
R2227 T3659 T3656 conj 3,1
R2228 T3660 T3656 punct ),1
R2229 T3661 T3646 punct ", ",association
R2230 T3662 T3663 amod profound,modulation
R2231 T3663 T3646 conj modulation,association
R2232 T3664 T3665 advmod in,vitro
R2233 T3665 T3663 amod vitro,modulation
R2234 T3666 T3663 prep of,modulation
R2235 T3667 T3668 npadvmod HKI,enzymatic
R2236 T3668 T3669 amod enzymatic,activity
R2237 T3669 T3666 pobj activity,of
R2238 T3670 T3663 prep by,modulation
R2239 T3671 T3670 pobj RanBP2,by
R2240 T3672 T3671 cc and,RanBP2
R2241 T3673 T3671 conj Cox11,RanBP2
R2242 T3674 T3675 punct (,Figure
R2243 T3675 T3663 parataxis Figure,modulation
R2244 T3676 T3675 nummod 2,Figure
R2245 T3677 T3675 punct ),Figure
R2246 T3678 T3663 punct ", ",modulation
R2247 T3679 T3663 cc and,modulation
R2248 T3680 T3681 det the,role
R2249 T3681 T3663 conj role,modulation
R2250 T3682 T3681 amod critical,role
R2251 T3683 T3681 prep of,role
R2252 T3684 T3683 pobj HKI,of
R2253 T3685 T3681 prep in,role
R2254 T3686 T3685 pcomp catalyzing,in
R2255 T3687 T3688 det a,step
R2256 T3688 T3686 dobj step,catalyzing
R2257 T3689 T3690 npadvmod rate,limiting
R2258 T3690 T3688 amod limiting,step
R2259 T3691 T3690 punct -,limiting
R2260 T3692 T3688 prep of,step
R2261 T3693 T3692 pobj glycolysis,of
R2262 T3694 T3642 punct ", ",probed
R2263 T3695 T3642 nsubj we,probed
R2264 T3696 T3697 mark whether,presented
R2265 T3697 T3642 ccomp presented,probed
R2266 T3698 T3699 nmod RanBP2,mice
R2267 T3699 T3697 nsubj mice,presented
R2268 T3700 T3698 punct +,RanBP2
R2269 T3701 T3698 punct /,RanBP2
R2270 T3702 T3698 punct −,RanBP2
R2271 T3703 T3697 dobj disturbances,presented
R2272 T3704 T3703 prep in,disturbances
R2273 T3705 T3704 pobj HKI,in
R2274 T3706 T3705 punct ", ",HKI
R2275 T3707 T3705 conj Cox11,HKI
R2276 T3708 T3707 punct ", ",Cox11
R2277 T3709 T3707 cc and,Cox11
R2278 T3710 T3711 compound energy,homeostasis
R2279 T3711 T3707 conj homeostasis,Cox11
R2280 T3712 T3642 punct .,probed
R2281 T3714 T3715 amod Monoallelic,expression
R2282 T3715 T3716 nsubj expression,affect
R2283 T3717 T3715 prep of,expression
R2284 T3718 T3717 pobj RanBP2,of
R2285 T3719 T3716 aux does,affect
R2286 T3720 T3716 neg not,affect
R2287 T3721 T3722 det the,number
R2288 T3722 T3716 dobj number,affect
R2289 T3723 T3722 prep of,number
R2290 T3724 T3723 pobj NPCs,of
R2291 T3725 T3722 cc and,number
R2292 T3726 T3727 poss their,distribution
R2293 T3727 T3722 conj distribution,number
R2294 T3728 T3727 prep in,distribution
R2295 T3729 T3730 amod hippocampal,neurons
R2296 T3730 T3728 pobj neurons,in
R2297 T3731 T3732 punct (,data
R2298 T3732 T3716 parataxis data,affect
R2299 T3733 T3734 compound Figure,5A
R2300 T3734 T3732 dep 5A,data
R2301 T3735 T3732 punct ", ",data
R2302 T3736 T3732 amod unpublished,data
R2303 T3737 T3732 punct ),data
R2304 T3738 T3716 punct ", ",affect
R2305 T3739 T3716 cc but,affect
R2306 T3740 T3741 nsubj it,led
R2307 T3741 T3716 conj led,affect
R2308 T3742 T3741 prep to,led
R2309 T3743 T3744 amod consistent,expression
R2310 T3744 T3742 pobj expression,to
R2311 T3745 T3744 amod lower,expression
R2312 T3746 T3744 prep of,expression
R2313 T3747 T3746 pobj RanBP2,of
R2314 T3748 T3744 prep by,expression
R2315 T3749 T3750 amod more,50
R2316 T3750 T3752 nummod 50,%
R2317 T3751 T3750 quantmod than,50
R2318 T3752 T3748 pobj %,by
R2319 T3753 T3744 prep in,expression
R2320 T3754 T3755 det the,CNS
R2321 T3755 T3753 pobj CNS,in
R2322 T3756 T3755 punct (,CNS
R2323 T3757 T3755 appos brain,CNS
R2324 T3758 T3757 cc and,brain
R2325 T3759 T3757 conj retina,brain
R2326 T3760 T3755 punct ),CNS
R2327 T3761 T3755 prep in,CNS
R2328 T3762 T3761 pobj 129Ola,in
R2329 T3763 T3764 punct (,5B
R2330 T3764 T3762 parataxis 5B,129Ola
R2331 T3765 T3764 compound Figure,5B
R2332 T3766 T3767 punct –,5D
R2333 T3767 T3764 prep 5D,5B
R2334 T3768 T3764 punct ),5B
R2335 T3769 T3761 punct ", ",in
R2336 T3770 T3761 cc but,in
R2337 T3771 T3770 neg not,but
R2338 T3772 T3761 conj in,in
R2339 T3773 T3774 compound C57BL,129Ola
R2340 T3774 T3778 compound 129Ola,backgrounds
R2341 T3775 T3774 punct /,129Ola
R2342 T3776 T3774 compound 6J,129Ola
R2343 T3777 T3774 punct /,129Ola
R2344 T3778 T3772 pobj backgrounds,in
R2345 T3779 T3780 punct (,data
R2346 T3780 T3741 meta data,led
R2347 T3781 T3780 amod unpublished,data
R2348 T3782 T3780 punct ),data
R2349 T3783 T3741 punct .,led
R2350 T3785 T3786 advmod Hence,focused
R2351 T3787 T3786 punct ", ",focused
R2352 T3788 T3786 nsubj we,focused
R2353 T3789 T3790 poss our,analysis
R2354 T3790 T3786 dobj analysis,focused
R2355 T3791 T3786 prep on,focused
R2356 T3792 T3793 det the,line
R2357 T3793 T3791 pobj line,on
R2358 T3794 T3793 amod inbred,line
R2359 T3795 T3793 nmod RanBP2,line
R2360 T3796 T3795 punct +,RanBP2
R2361 T3797 T3795 punct /,RanBP2
R2362 T3798 T3795 punct −,RanBP2
R2363 T3799 T3793 compound 129Ola,line
R2364 T3800 T3793 compound mouse,line
R2365 T3801 T3786 punct .,focused
R2366 T3803 T3804 mark Although,decreased
R2367 T3804 T3810 advcl decreased,remained
R2368 T3805 T3806 det the,levels
R2369 T3806 T3804 nsubjpass levels,decreased
R2370 T3807 T3806 prep of,levels
R2371 T3808 T3807 pobj RanBP2,of
R2372 T3809 T3804 auxpass were,decreased
R2373 T3811 T3804 prep in,decreased
R2374 T3812 T3813 det the,retina
R2375 T3813 T3811 pobj retina,in
R2376 T3814 T3813 punct ", ",retina
R2377 T3815 T3813 conj brain,retina
R2378 T3816 T3815 punct ", ",brain
R2379 T3817 T3815 cc and,brain
R2380 T3818 T3815 conj hippocampus,brain
R2381 T3819 T3813 prep of,retina
R2382 T3820 T3821 nmod RanBP2,mice
R2383 T3821 T3819 pobj mice,of
R2384 T3822 T3820 punct +,RanBP2
R2385 T3823 T3820 punct /,RanBP2
R2386 T3824 T3820 punct −,RanBP2
R2387 T3825 T3804 prep by,decreased
R2388 T3826 T3827 punct ~,50
R2389 T3827 T3828 nummod 50,%
R2390 T3828 T3825 pobj %,by
R2391 T3829 T3830 punct –,%
R2392 T3830 T3828 prep %,%
R2393 T3831 T3830 nummod 60,%
R2394 T3832 T3833 punct (,5B
R2395 T3833 T3804 parataxis 5B,decreased
R2396 T3834 T3833 compound Figure,5B
R2397 T3835 T3833 cc and,5B
R2398 T3836 T3833 conj 5C,5B
R2399 T3837 T3833 punct ),5B
R2400 T3838 T3810 punct ", ",remained
R2401 T3839 T3840 det the,levels
R2402 T3840 T3810 nsubj levels,remained
R2403 T3841 T3840 prep of,levels
R2404 T3842 T3843 compound others,nucleoporins
R2405 T3843 T3841 pobj nucleoporins,of
R2406 T3844 T3843 punct ", ",nucleoporins
R2407 T3845 T3843 appos Nup153,nucleoporins
R2408 T3846 T3845 cc and,Nup153
R2409 T3847 T3845 conj Nup62,Nup153
R2410 T3848 T3843 punct ", ",nucleoporins
R2411 T3849 T3843 cc and,nucleoporins
R2412 T3850 T3843 conj mHsp70,nucleoporins
R2413 T3851 T3850 cc and,mHsp70
R2414 T3852 T3850 conj Cox11,mHsp70
R2415 T3853 T3810 punct ", ",remained
R2416 T3854 T3810 acomp unchanged,remained
R2417 T3855 T3856 punct (,data
R2418 T3856 T3810 parataxis data,remained
R2419 T3857 T3858 compound Figure,5B
R2420 T3858 T3856 dep 5B,data
R2421 T3859 T3856 punct ", ",data
R2422 T3860 T3856 amod unpublished,data
R2423 T3861 T3856 punct ),data
R2424 T3862 T3810 punct .,remained
R2425 T3864 T3865 prep In,observed
R2426 T3866 T3864 pobj addition,In
R2427 T3867 T3865 punct ", ",observed
R2428 T3868 T3865 nsubj we,observed
R2429 T3869 T3870 det a,decrease
R2430 T3870 T3865 dobj decrease,observed
R2431 T3871 T3870 amod strong,decrease
R2432 T3872 T3870 prep of,decrease
R2433 T3873 T3874 det the,levels
R2434 T3874 T3872 pobj levels,of
R2435 T3875 T3874 prep of,levels
R2436 T3876 T3875 pobj HKI,of
R2437 T3877 T3870 punct (,decrease
R2438 T3878 T3870 appos 3,decrease
R2439 T3879 T3878 punct -,3
R2440 T3880 T3878 quantmod to,3
R2441 T3881 T3878 advmod 4-fold,3
R2442 T3882 T3865 punct ),observed
R2443 T3883 T3884 punct (,5B
R2444 T3884 T3865 parataxis 5B,observed
R2445 T3885 T3884 compound Figure,5B
R2446 T3886 T3884 cc and,5B
R2447 T3887 T3884 conj 5C,5B
R2448 T3888 T3884 punct ),5B
R2449 T3889 T3865 punct .,observed
R2450 T3891 T3892 det This,decrease
R2451 T3892 T3893 nsubj decrease,was
R2452 T3894 T3893 acomp selective,was
R2453 T3895 T3894 prep to,selective
R2454 T3896 T3897 det the,CNS
R2455 T3897 T3895 pobj CNS,to
R2456 T3898 T3893 punct ", ",was
R2457 T3899 T3900 mark since,remained
R2458 T3900 T3893 advcl remained,was
R2459 T3901 T3902 compound HKI,levels
R2460 T3902 T3900 nsubj levels,remained
R2461 T3903 T3904 advmod largely,unaffected
R2462 T3904 T3900 acomp unaffected,remained
R2463 T3905 T3900 prep in,remained
R2464 T3906 T3907 det the,muscle
R2465 T3907 T3905 pobj muscle,in
R2466 T3908 T3907 amod skeletal,muscle
R2467 T3909 T3907 punct ", ",muscle
R2468 T3910 T3907 conj spleen,muscle
R2469 T3911 T3910 punct ", ",spleen
R2470 T3912 T3910 cc and,spleen
R2471 T3913 T3910 conj liver,spleen
R2472 T3914 T3915 punct (,5D
R2473 T3915 T3893 parataxis 5D,was
R2474 T3916 T3915 compound Figure,5D
R2475 T3917 T3915 punct ),5D
R2476 T3918 T3893 punct .,was
R2477 T3920 T3921 mark Because,plays
R2478 T3921 T3923 advcl plays,probed
R2479 T3922 T3921 nsubj HKI,plays
R2480 T3924 T3925 det a,role
R2481 T3925 T3921 dobj role,plays
R2482 T3926 T3925 amod key,role
R2483 T3927 T3921 prep in,plays
R2484 T3928 T3929 det the,production
R2485 T3929 T3927 pobj production,in
R2486 T3930 T3929 prep of,production
R2487 T3931 T3932 nmod energy,substrates
R2488 T3932 T3930 pobj substrates,of
R2489 T3933 T3932 amod intermediate,substrates
R2490 T3934 T3921 cc and,plays
R2491 T3935 T3936 nsubj HKI,is
R2492 T3936 T3921 conj is,plays
R2493 T3937 T3938 advmod virtually,isoform
R2494 T3938 T3936 attr isoform,is
R2495 T3939 T3938 det the,isoform
R2496 T3940 T3938 amod sole,isoform
R2497 T3941 T3938 compound HK,isoform
R2498 T3942 T3938 acl expressed,isoform
R2499 T3943 T3942 prep in,expressed
R2500 T3944 T3945 det the,CNS
R2501 T3945 T3943 pobj CNS,in
R2502 T3946 T3947 punct [,34
R2503 T3947 T3936 parataxis 34,is
R2504 T3948 T3947 nummod 33,34
R2505 T3949 T3947 punct ",",34
R2506 T3950 T3947 punct ],34
R2507 T3951 T3923 punct ", ",probed
R2508 T3952 T3923 nsubj we,probed
R2509 T3953 T3954 det the,impact
R2510 T3954 T3923 dobj impact,probed
R2511 T3955 T3954 prep of,impact
R2512 T3956 T3957 nmod HKI,reduction
R2513 T3957 T3955 pobj reduction,of
R2514 T3958 T3956 cc and,HKI
R2515 T3959 T3956 conj RanBP2,HKI
R2516 T3960 T3954 prep in,impact
R2517 T3961 T3962 det the,levels
R2518 T3962 T3960 pobj levels,in
R2519 T3963 T3962 prep of,levels
R2520 T3964 T3963 pobj ATP,of
R2521 T3965 T3923 punct .,probed
R2522 T3967 T3968 mark As,shown
R2523 T3968 T3969 advcl shown,was
R2524 T3970 T3968 prep in,shown
R2525 T3971 T3972 compound Figure,5E
R2526 T3972 T3970 pobj 5E,in
R2527 T3973 T3969 punct ", ",was
R2528 T3974 T3969 expl there,was
R2529 T3975 T3976 amod significant,reduction
R2530 T3976 T3969 attr reduction,was
R2531 T3977 T3975 cc and,significant
R2532 T3978 T3975 conj concordant,significant
R2533 T3979 T3976 prep in,reduction
R2534 T3980 T3979 pobj levels,in
R2535 T3981 T3980 prep of,levels
R2536 T3982 T3981 pobj ATP,of
R2537 T3983 T3980 prep in,levels
R2538 T3984 T3985 det the,CNS
R2539 T3985 T3983 pobj CNS,in
R2540 T3986 T3985 punct (,CNS
R2541 T3987 T3985 appos brain,CNS
R2542 T3988 T3987 cc and,brain
R2543 T3989 T3987 conj retina,brain
R2544 T3990 T3983 punct ),in
R2545 T3991 T3983 punct ", ",in
R2546 T3992 T3983 cc but,in
R2547 T3993 T3992 neg not,but
R2548 T3994 T3983 conj in,in
R2549 T3995 T3996 amod non-neuronal,tissues
R2550 T3996 T3994 pobj tissues,in
R2551 T3997 T3969 punct .,was
R2552 T3999 T4000 advmod Finally,observed
R2553 T4001 T4000 punct ", ",observed
R2554 T4002 T4000 nsubj we,observed
R2555 T4003 T4000 advmod also,observed
R2556 T4004 T4005 amod partial,delocalization
R2557 T4005 T4000 dobj delocalization,observed
R2558 T4006 T4004 cc and,partial
R2559 T4007 T4004 conj selective,partial
R2560 T4008 T4005 prep of,delocalization
R2561 T4009 T4008 pobj HKI,of
R2562 T4010 T4008 punct ", ",of
R2563 T4011 T4008 cc but,of
R2564 T4012 T4011 neg not,but
R2565 T4013 T4008 conj of,of
R2566 T4014 T4013 pobj Cox11,of
R2567 T4015 T4005 punct ", ",delocalization
R2568 T4016 T4005 prep from,delocalization
R2569 T4017 T4018 det the,ellipsoid
R2570 T4018 T4016 pobj ellipsoid,from
R2571 T4019 T4018 punct (,ellipsoid
R2572 T4020 T4021 npadvmod mitochondria,rich
R2573 T4021 T4018 amod rich,ellipsoid
R2574 T4022 T4021 punct -,rich
R2575 T4023 T4018 punct ),ellipsoid
R2576 T4024 T4016 prep to,from
R2577 T4025 T4026 det the,myoid
R2578 T4026 T4024 pobj myoid,to
R2579 T4027 T4026 amod adjacent,myoid
R2580 T4028 T4029 amod subcellular,compartment
R2581 T4029 T4016 pobj compartment,from
R2582 T4030 T4029 prep of,compartment
R2583 T4031 T4032 nmod rod,neurons
R2584 T4032 T4030 pobj neurons,of
R2585 T4033 T4032 amod photosensory,neurons
R2586 T4034 T4035 punct (,S2A
R2587 T4035 T4005 parataxis S2A,delocalization
R2588 T4036 T4035 compound Figure,S2A
R2589 T4037 T4038 punct –,S2E
R2590 T4038 T4035 prep S2E,S2A
R2591 T4039 T4035 punct ),S2A
R2592 T4040 T4000 punct .,observed
R2593 T4042 T4043 nsubjpass This,accompanied
R2594 T4044 T4043 auxpass was,accompanied
R2595 T4045 T4043 advmod also,accompanied
R2596 T4046 T4043 agent by,accompanied
R2597 T4047 T4048 amod reduced,levels
R2598 T4048 T4046 pobj levels,by
R2599 T4049 T4048 compound HKI,levels
R2600 T4050 T4048 prep in,levels
R2601 T4051 T4052 det the,retina
R2602 T4052 T4050 pobj retina,in
R2603 T4053 T4052 amod inner,retina
R2604 T4054 T4050 punct ", ",in
R2605 T4055 T4056 prep in,in
R2606 T4056 T4050 prep in,in
R2607 T4057 T4055 amod particular,in
R2608 T4058 T4059 det the,layer
R2609 T4059 T4056 pobj layer,in
R2610 T4060 T4059 amod inner,layer
R2611 T4061 T4059 amod plexiform,layer
R2612 T4062 T4059 punct (,layer
R2613 T4063 T4059 amod synaptic,layer
R2614 T4064 T4059 punct ),layer
R2615 T4065 T4066 punct (,S2A
R2616 T4066 T4043 parataxis S2A,accompanied
R2617 T4067 T4066 compound Figure,S2A
R2618 T4068 T4069 punct –,S2E
R2619 T4069 T4066 prep S2E,S2A
R2620 T4070 T4066 punct ),S2A
R2621 T4071 T4043 punct .,accompanied
R2626 T4308 T4309 amod Metabolic,Disturbances
R2627 T4310 T4309 acl Caused,Disturbances
R2628 T4311 T4310 agent by,Caused
R2629 T4312 T4311 pobj Haploinsufficiency,by
R2630 T4313 T4312 prep of,Haploinsufficiency
R2631 T4314 T4313 pobj RanBP2,of
R2632 T4316 T4317 det The,rates
R2633 T4317 T4319 nsubj rates,were
R2634 T4318 T4317 compound growth,rates
R2635 T4320 T4317 prep of,rates
R2636 T4321 T4322 amod inbred,mice
R2637 T4322 T4320 pobj mice,of
R2638 T4323 T4322 nmod RanBP2,mice
R2639 T4324 T4323 punct +,RanBP2
R2640 T4325 T4323 punct /,RanBP2
R2641 T4326 T4323 punct −,RanBP2
R2642 T4327 T4322 prep on,mice
R2643 T4328 T4329 amod high,fat
R2644 T4329 T4331 nmod fat,diet
R2645 T4330 T4329 punct -,fat
R2646 T4331 T4327 pobj diet,on
R2647 T4332 T4329 punct (,fat
R2648 T4333 T4334 punct ~,10
R2649 T4334 T4335 nummod 10,%
R2650 T4335 T4336 compound %,fat
R2651 T4336 T4329 appos fat,fat
R2652 T4337 T4331 punct ),diet
R2653 T4338 T4339 advmod significantly,slower
R2654 T4339 T4319 acomp slower,were
R2655 T4340 T4339 prep than,slower
R2656 T4341 T4342 nmod RanBP2,mice
R2657 T4342 T4340 pobj mice,than
R2658 T4343 T4341 punct +,RanBP2
R2659 T4344 T4341 punct /,RanBP2
R2660 T4345 T4341 punct +,RanBP2
R2661 T4346 T4347 punct (,6A
R2662 T4347 T4319 parataxis 6A,were
R2663 T4348 T4347 compound Figure,6A
R2664 T4349 T4347 punct ),6A
R2665 T4350 T4319 punct .,were
R2666 T4352 T4353 advcl Beginning,exhibit
R2667 T4354 T4352 prep at,Beginning
R2668 T4355 T4356 quantmod around,4
R2669 T4356 T4357 nummod 4,mo
R2670 T4357 T4354 pobj mo,at
R2671 T4358 T4357 prep of,mo
R2672 T4359 T4358 pobj age,of
R2673 T4360 T4353 punct ", ",exhibit
R2674 T4361 T4362 nmod RanBP2,mice
R2675 T4362 T4353 nsubj mice,exhibit
R2676 T4363 T4361 punct +,RanBP2
R2677 T4364 T4361 punct /,RanBP2
R2678 T4365 T4361 punct −,RanBP2
R2679 T4366 T4367 det a,gain
R2680 T4367 T4353 dobj gain,exhibit
R2681 T4368 T4369 amod significant,slower
R2682 T4369 T4367 amod slower,gain
R2683 T4370 T4367 prep in,gain
R2684 T4371 T4372 compound body,mass
R2685 T4372 T4370 pobj mass,in
R2686 T4373 T4367 prep than,gain
R2687 T4374 T4375 amod wild,type
R2688 T4375 T4377 compound type,mice
R2689 T4376 T4375 punct -,type
R2690 T4377 T4373 pobj mice,than
R2691 T4378 T4379 punct (,6A
R2692 T4379 T4353 parataxis 6A,exhibit
R2693 T4380 T4379 compound Figure,6A
R2694 T4381 T4379 punct ),6A
R2695 T4382 T4353 punct .,exhibit
R2696 T4384 T4385 prep In,presented
R2697 T4386 T4384 pobj addition,In
R2698 T4387 T4385 punct ", ",presented
R2699 T4388 T4389 nmod RanBP2,mice
R2700 T4389 T4385 nsubj mice,presented
R2701 T4390 T4388 punct +,RanBP2
R2702 T4391 T4388 punct /,RanBP2
R2703 T4392 T4388 punct −,RanBP2
R2704 T4393 T4389 amod inbred,mice
R2705 T4394 T4385 dobj deficits,presented
R2706 T4395 T4394 prep in,deficits
R2707 T4396 T4397 compound body,mass
R2708 T4397 T4395 pobj mass,in
R2709 T4398 T4399 dep that,erased
R2710 T4399 T4394 relcl erased,deficits
R2711 T4400 T4399 auxpass were,erased
R2712 T4401 T4399 prep by,erased
R2713 T4402 T4401 pcomp changing,by
R2714 T4403 T4404 det the,background
R2715 T4404 T4402 dobj background,changing
R2716 T4405 T4404 amod genetic,background
R2717 T4406 T4402 prep to,changing
R2718 T4407 T4408 det a,129Ola
R2719 T4408 T4406 pobj 129Ola,to
R2720 T4409 T4408 amod mixed,129Ola
R2721 T4410 T4408 compound C57BL,129Ola
R2722 T4411 T4408 punct /,129Ola
R2723 T4412 T4408 compound 6J,129Ola
R2724 T4413 T4408 punct /,129Ola
R2725 T4414 T4415 punct (,6B
R2726 T4415 T4385 parataxis 6B,presented
R2727 T4416 T4415 compound Figure,6B
R2728 T4417 T4415 punct ),6B
R2729 T4418 T4385 punct .,presented
R2730 T4420 T4421 compound Food,consumption
R2731 T4421 T4422 nsubj consumption,account
R2732 T4423 T4422 aux did,account
R2733 T4424 T4422 neg not,account
R2734 T4425 T4422 prep for,account
R2735 T4426 T4427 det the,differences
R2736 T4427 T4425 pobj differences,for
R2737 T4428 T4429 compound body,weight
R2738 T4429 T4427 compound weight,differences
R2739 T4430 T4427 acl observed,differences
R2740 T4431 T4432 punct (,6C
R2741 T4432 T4422 parataxis 6C,account
R2742 T4433 T4432 compound Figure,6C
R2743 T4434 T4432 punct ),6C
R2744 T4435 T4422 punct .,account
R2745 T4437 T4438 nsubj HKI,accounts
R2746 T4439 T4437 prep in,HKI
R2747 T4440 T4441 det the,CNS
R2748 T4441 T4439 pobj CNS,in
R2749 T4442 T4441 punct (,CNS
R2750 T4443 T4441 appos brain,CNS
R2751 T4444 T4443 cc and,brain
R2752 T4445 T4443 conj retina,brain
R2753 T4446 T4438 punct ),accounts
R2754 T4447 T4438 advmod virtually,accounts
R2755 T4448 T4438 prep for,accounts
R2756 T4449 T4450 det all,expression
R2757 T4450 T4448 pobj expression,for
R2758 T4451 T4450 prep of,expression
R2759 T4452 T4453 compound HK,isozymes
R2760 T4453 T4451 pobj isozymes,of
R2761 T4454 T4450 cc and,expression
R2762 T4455 T4456 compound glucose,utilization
R2763 T4456 T4450 conj utilization,expression
R2764 T4457 T4450 prep in,expression
R2765 T4458 T4459 det the,CNS
R2766 T4459 T4457 pobj CNS,in
R2767 T4460 T4461 punct [,34
R2768 T4461 T4438 parataxis 34,accounts
R2769 T4462 T4461 nummod 33,34
R2770 T4463 T4461 punct ",",34
R2771 T4464 T4461 punct ],34
R2772 T4465 T4438 punct .,accounts
R2773 T4467 T4468 advmod Moreover,is
R2774 T4469 T4468 punct ", ",is
R2775 T4470 T4468 nsubj glucose,is
R2776 T4471 T4472 det the,source
R2777 T4472 T4468 attr source,is
R2778 T4473 T4472 amod sole,source
R2779 T4474 T4472 compound reliance,source
R2780 T4475 T4472 prep of,source
R2781 T4476 T4475 pobj energy,of
R2782 T4477 T4472 prep in,source
R2783 T4478 T4479 det the,CNS
R2784 T4479 T4477 pobj CNS,in
R2785 T4480 T4472 prep under,source
R2786 T4481 T4482 amod normal,conditions
R2787 T4482 T4480 pobj conditions,under
R2788 T4483 T4468 punct ", ",is
R2789 T4484 T4485 det the,CNS
R2790 T4485 T4486 nsubj CNS,lacks
R2791 T4486 T4468 conj lacks,is
R2792 T4487 T4488 compound glucose,storage
R2793 T4488 T4489 compound storage,sources
R2794 T4489 T4486 dobj sources,lacks
R2795 T4490 T4486 punct ", ",lacks
R2796 T4491 T4486 cc and,lacks
R2797 T4492 T4493 prep despite,consumes
R2798 T4493 T4486 conj consumes,lacks
R2799 T4494 T4495 det the,mass
R2800 T4495 T4492 pobj mass,despite
R2801 T4496 T4495 amod disproportionate,mass
R2802 T4497 T4495 prep of,mass
R2803 T4498 T4499 det the,CNS
R2804 T4499 T4497 pobj CNS,of
R2805 T4500 T4495 prep to,mass
R2806 T4501 T4502 det the,rest
R2807 T4502 T4500 pobj rest,to
R2808 T4503 T4502 prep of,rest
R2809 T4504 T4505 det the,body
R2810 T4505 T4503 pobj body,of
R2811 T4506 T4493 punct ", ",consumes
R2812 T4507 T4508 det the,CNS
R2813 T4508 T4493 nsubj CNS,consumes
R2814 T4509 T4493 advmod daily,consumes
R2815 T4510 T4511 quantmod about,60
R2816 T4511 T4512 nummod 60,%
R2817 T4512 T4493 dobj %,consumes
R2818 T4513 T4512 prep of,%
R2819 T4514 T4515 det the,body
R2820 T4515 T4516 poss body,glucose
R2821 T4516 T4513 pobj glucose,of
R2822 T4517 T4515 case 's,body
R2823 T4518 T4512 cc and,%
R2824 T4519 T4520 nummod 25,%
R2825 T4520 T4512 conj %,%
R2826 T4521 T4520 prep of,%
R2827 T4522 T4523 det the,oxygen
R2828 T4523 T4521 pobj oxygen,of
R2829 T4524 T4523 amod total,oxygen
R2830 T4525 T4526 punct [,36
R2831 T4526 T4493 parataxis 36,consumes
R2832 T4527 T4526 nummod 35,36
R2833 T4528 T4526 punct ",",36
R2834 T4529 T4526 punct ],36
R2835 T4530 T4493 punct .,consumes
R2836 T4532 T4533 aux To,determine
R2837 T4533 T4534 advcl determine,carried
R2838 T4535 T4536 det the,impact
R2839 T4536 T4533 dobj impact,determine
R2840 T4537 T4536 prep of,impact
R2841 T4538 T4539 compound RanBP2,haploinsufficiency
R2842 T4539 T4537 pobj haploinsufficiency,of
R2843 T4540 T4536 prep on,impact
R2844 T4541 T4542 det the,utilization
R2845 T4542 T4540 pobj utilization,on
R2846 T4543 T4542 punct ", ",utilization
R2847 T4544 T4542 conj formation,utilization
R2848 T4545 T4544 punct ", ",formation
R2849 T4546 T4544 cc and,formation
R2850 T4547 T4544 conj uptake,formation
R2851 T4548 T4542 prep of,utilization
R2852 T4549 T4548 pobj glucose,of
R2853 T4550 T4534 punct ", ",carried
R2854 T4551 T4534 nsubj we,carried
R2855 T4552 T4534 prt out,carried
R2856 T4553 T4554 amod several,assays
R2857 T4554 T4534 dobj assays,carried
R2858 T4555 T4554 amod physiological,assays
R2859 T4556 T4534 punct .,carried
R2860 T4558 T4559 prep In,performed
R2861 T4560 T4558 pobj contrast,In
R2862 T4561 T4560 prep to,contrast
R2863 T4562 T4561 pobj mice,to
R2864 T4563 T4562 acl placed,mice
R2865 T4564 T4563 prep on,placed
R2866 T4565 T4566 det a,diet
R2867 T4566 T4564 pobj diet,on
R2868 T4567 T4566 amod normal,diet
R2869 T4568 T4566 compound chow,diet
R2870 T4569 T4570 punct (,data
R2871 T4570 T4566 parataxis data,diet
R2872 T4571 T4572 punct ~,5
R2873 T4572 T4573 nummod 5,%
R2874 T4573 T4574 compound %,fat
R2875 T4574 T4570 dep fat,data
R2876 T4575 T4570 punct ;,data
R2877 T4576 T4570 amod unpublished,data
R2878 T4577 T4570 punct ),data
R2879 T4578 T4559 punct ", ",performed
R2880 T4579 T4580 nmod RanBP2,mice
R2881 T4580 T4559 nsubj mice,performed
R2882 T4581 T4579 punct +,RanBP2
R2883 T4582 T4579 punct /,RanBP2
R2884 T4583 T4579 punct −,RanBP2
R2885 T4584 T4580 prep on,mice
R2886 T4585 T4586 det a,diet
R2887 T4586 T4584 pobj diet,on
R2888 T4587 T4588 amod higher,fat
R2889 T4588 T4586 compound fat,diet
R2890 T4589 T4590 punct (,fat
R2891 T4590 T4586 parataxis fat,diet
R2892 T4591 T4592 punct ~,10
R2893 T4592 T4593 nummod 10,%
R2894 T4593 T4590 compound %,fat
R2895 T4594 T4590 punct ),fat
R2896 T4595 T4596 advmod significantly,worse
R2897 T4596 T4559 advmod worse,performed
R2898 T4597 T4559 prep in,performed
R2899 T4598 T4599 det the,test
R2900 T4599 T4597 pobj test,in
R2901 T4600 T4601 compound glucose,tolerance
R2902 T4601 T4599 compound tolerance,test
R2903 T4602 T4559 advcl beginning,performed
R2904 T4603 T4602 prep at,beginning
R2905 T4604 T4605 nummod 6,mo
R2906 T4605 T4603 pobj mo,at
R2907 T4606 T4605 prep of,mo
R2908 T4607 T4606 pobj age,of
R2909 T4608 T4609 punct (,7A
R2910 T4609 T4602 parataxis 7A,beginning
R2911 T4610 T4609 compound Figure,7A
R2912 T4611 T4609 cc and,7A
R2913 T4612 T4609 conj 7B,7A
R2914 T4613 T4609 punct ),7A
R2915 T4614 T4559 punct ", ",performed
R2916 T4615 T4616 advmod thus,supporting
R2917 T4616 T4559 advcl supporting,performed
R2918 T4617 T4618 mark that,exhibited
R2919 T4618 T4616 ccomp exhibited,supporting
R2920 T4619 T4620 det the,mice
R2921 T4620 T4618 nsubj mice,exhibited
R2922 T4621 T4620 nmod RanBP2,mice
R2923 T4622 T4621 punct +,RanBP2
R2924 T4623 T4621 punct /,RanBP2
R2925 T4624 T4621 punct −,RanBP2
R2926 T4625 T4626 det a,deficit
R2927 T4626 T4618 dobj deficit,exhibited
R2928 T4627 T4626 prep in,deficit
R2929 T4628 T4629 compound glucose,clearance
R2930 T4629 T4627 pobj clearance,in
R2931 T4630 T4559 punct .,performed
R2932 T4632 T4633 det This,deficit
R2933 T4633 T4634 nsubjpass deficit,rescued
R2934 T4635 T4634 auxpass was,rescued
R2935 T4636 T4634 prep in,rescued
R2936 T4637 T4638 nmod RanBP2,mice
R2937 T4638 T4636 pobj mice,in
R2938 T4639 T4637 punct +,RanBP2
R2939 T4640 T4637 punct /,RanBP2
R2940 T4641 T4637 punct −,RanBP2
R2941 T4642 T4638 prep of,mice
R2942 T4643 T4644 amod mixed,background
R2943 T4644 T4642 pobj background,of
R2944 T4645 T4646 compound C57BL,129Ola
R2945 T4646 T4644 compound 129Ola,background
R2946 T4647 T4646 punct /,129Ola
R2947 T4648 T4646 compound 6J,129Ola
R2948 T4649 T4646 punct /,129Ola
R2949 T4650 T4651 punct (,S3
R2950 T4651 T4634 parataxis S3,rescued
R2951 T4652 T4651 compound Figure,S3
R2952 T4653 T4651 punct ),S3
R2953 T4654 T4634 punct .,rescued
R2954 T4656 T4657 compound Glucose,clearance
R2955 T4657 T4658 nsubjpass clearance,affected
R2956 T4659 T4658 auxpass was,affected
R2957 T4660 T4658 neg not,affected
R2958 T4661 T4658 prep due,affected
R2959 T4662 T4661 pcomp to,due
R2960 T4663 T4664 det a,disturbance
R2961 T4664 T4661 pobj disturbance,due
R2962 T4665 T4664 prep in,disturbance
R2963 T4666 T4667 npadvmod insulin,mediated
R2964 T4667 T4669 amod mediated,uptake
R2965 T4668 T4667 punct -,mediated
R2966 T4669 T4665 pobj uptake,in
R2967 T4670 T4669 compound glucose,uptake
R2968 T4671 T4672 punct (,7C
R2969 T4672 T4658 parataxis 7C,affected
R2970 T4673 T4672 compound Figure,7C
R2971 T4674 T4672 punct ),7C
R2972 T4675 T4658 punct .,affected
R2973 T4677 T4678 advmod Then,probed
R2974 T4679 T4678 punct ", ",probed
R2975 T4680 T4678 nsubj we,probed
R2976 T4681 T4682 mark whether,induces
R2977 T4682 T4678 ccomp induces,probed
R2978 T4683 T4682 nsubj RanBP2,induces
R2979 T4684 T4682 dobj impairment,induces
R2980 T4685 T4684 prep of,impairment
R2981 T4686 T4685 pobj gluconeogenesis,of
R2982 T4687 T4684 punct ", ",impairment
R2983 T4688 T4689 dep which,contribute
R2984 T4689 T4684 relcl contribute,impairment
R2985 T4690 T4689 aux could,contribute
R2986 T4691 T4689 prep to,contribute
R2987 T4692 T4693 det the,production
R2988 T4693 T4691 pobj production,to
R2989 T4694 T4693 amod pathophysiological,production
R2990 T4695 T4693 cc and,production
R2991 T4696 T4693 conj clearance,production
R2992 T4697 T4693 prep of,production
R2993 T4698 T4697 pobj glucose,of
R2994 T4699 T4678 punct .,probed
R2995 T4701 T4702 prep To,showed
R2996 T4703 T4704 det this,end
R2997 T4704 T4701 pobj end,To
R2998 T4705 T4702 punct ", ",showed
R2999 T4706 T4707 det the,administration
R3000 T4707 T4702 nsubj administration,showed
R3001 T4708 T4707 prep of,administration
R3002 T4709 T4710 det the,precursor
R3003 T4710 T4708 pobj precursor,of
R3004 T4711 T4712 amod gluconeogenic,substrate
R3005 T4712 T4710 compound substrate,precursor
R3006 T4713 T4710 punct ", ",precursor
R3007 T4714 T4710 appos pyruvate,precursor
R3008 T4715 T4707 punct (,administration
R3009 T4716 T4717 compound pyruvate,tolerance
R3010 T4717 T4718 compound tolerance,test
R3011 T4718 T4707 appos test,administration
R3012 T4719 T4702 punct ),showed
R3013 T4720 T4702 punct ", ",showed
R3014 T4721 T4722 mark that,was
R3015 T4722 T4702 ccomp was,showed
R3016 T4723 T4722 expl there,was
R3017 T4724 T4725 det no,difference
R3018 T4725 T4722 attr difference,was
R3019 T4726 T4725 prep in,difference
R3020 T4727 T4728 compound glucose,production
R3021 T4728 T4726 pobj production,in
R3022 T4729 T4722 prep in,was
R3023 T4730 T4731 nmod RanBP2,mice
R3024 T4731 T4729 pobj mice,in
R3025 T4732 T4730 punct +,RanBP2
R3026 T4733 T4730 punct /,RanBP2
R3027 T4734 T4730 punct −,RanBP2
R3028 T4735 T4736 punct (,7D
R3029 T4736 T4722 parataxis 7D,was
R3030 T4737 T4736 compound Figure,7D
R3031 T4738 T4736 punct ),7D
R3032 T4739 T4702 punct .,showed
R3033 T4741 T4742 advmod Hence,had
R3034 T4743 T4742 punct ", ",had
R3035 T4744 T4745 amod partial,loss
R3036 T4745 T4742 nsubj loss,had
R3037 T4746 T4745 punct -,loss
R3038 T4747 T4745 prep of,loss
R3039 T4748 T4747 punct -,of
R3040 T4749 T4747 pobj function,of
R3041 T4750 T4745 prep of,loss
R3042 T4751 T4750 pobj RanBP2,of
R3043 T4752 T4753 det no,impact
R3044 T4753 T4742 dobj impact,had
R3045 T4754 T4753 prep on,impact
R3046 T4755 T4756 det the,pathway
R3047 T4756 T4754 pobj pathway,on
R3048 T4757 T4756 compound gluconeogenesis,pathway
R3049 T4758 T4742 punct .,had
R3050 T4760 T4761 advmod However,were
R3051 T4762 T4761 punct ", ",were
R3052 T4763 T4761 prep upon,were
R3053 T4764 T4765 compound glucose,production
R3054 T4765 T4763 pobj production,upon
R3055 T4766 T4767 punct (,min
R3056 T4767 T4765 parataxis min,production
R3057 T4768 T4767 nummod 15,min
R3058 T4769 T4767 punct ),min
R3059 T4770 T4761 punct ", ",were
R3060 T4771 T4772 det the,rates
R3061 T4772 T4761 nsubj rates,were
R3062 T4773 T4772 compound clearance,rates
R3063 T4774 T4772 prep of,rates
R3064 T4775 T4774 pobj glucose,of
R3065 T4776 T4761 advmod again,were
R3066 T4777 T4778 advmod significantly,slower
R3067 T4778 T4761 acomp slower,were
R3068 T4779 T4761 prep in,were
R3069 T4780 T4779 pobj RanBP2,in
R3070 T4781 T4780 punct +,RanBP2
R3071 T4782 T4780 punct /,RanBP2
R3072 T4783 T4780 punct −,RanBP2
R3073 T4784 T4761 prep than,were
R3074 T4785 T4784 prep in,than
R3075 T4786 T4787 nmod RanBP2,mice
R3076 T4787 T4785 pobj mice,in
R3077 T4788 T4786 punct +,RanBP2
R3078 T4789 T4786 punct /,RanBP2
R3079 T4790 T4786 punct +,RanBP2
R3080 T4791 T4792 punct (,7D
R3081 T4792 T4787 parataxis 7D,mice
R3082 T4793 T4792 compound Figure,7D
R3083 T4794 T4792 punct ),7D
R3084 T4795 T4761 punct ", ",were
R3085 T4796 T4761 advcl confirming,were
R3086 T4797 T4798 det an,impairment
R3087 T4798 T4796 dobj impairment,confirming
R3088 T4799 T4798 prep in,impairment
R3089 T4800 T4801 compound glucose,breakdown
R3090 T4801 T4799 pobj breakdown,in
R3091 T4802 T4761 punct .,were
R3106 T5002 T5003 nsubj Haploinsufficiency,Causes
R3107 T5004 T5002 prep of,Haploinsufficiency
R3108 T5005 T5004 pobj RanBP2,of
R3109 T5006 T5003 dobj Deficits,Causes
R3110 T5007 T5003 prep in,Causes
R3111 T5008 T5009 det the,Output
R3112 T5009 T5007 pobj Output,in
R3113 T5010 T5009 amod Electrophysiological,Output
R3114 T5011 T5009 prep of,Output
R3115 T5012 T5013 amod Receptoral,Neurons
R3116 T5013 T5011 pobj Neurons,of
R3117 T5014 T5012 cc and,Receptoral
R3118 T5015 T5012 conj Postreceptoral,Receptoral
R3119 T5016 T5013 amod Retinal,Neurons
R3120 T5018 T5019 prep In,probed
R3121 T5020 T5018 pobj light,In
R3122 T5021 T5020 prep of,light
R3123 T5022 T5023 det the,expression
R3124 T5023 T5021 pobj expression,of
R3125 T5024 T5023 amod prominent,expression
R3126 T5025 T5023 prep of,expression
R3127 T5026 T5025 pobj RanBP2,of
R3128 T5027 T5026 cc and,RanBP2
R3129 T5028 T5026 conj HKI,RanBP2
R3130 T5029 T5023 prep in,expression
R3131 T5030 T5031 amod retinal,neurons
R3132 T5031 T5029 pobj neurons,in
R3133 T5032 T5033 punct [,19
R3134 T5033 T5023 parataxis 19,expression
R3135 T5034 T5033 nummod 1,19
R3136 T5035 T5033 punct ",",19
R3137 T5036 T5033 punct ],19
R3138 T5037 T5023 punct ", ",expression
R3139 T5038 T5039 det the,dependence
R3140 T5039 T5023 conj dependence,expression
R3141 T5040 T5039 amod vital,dependence
R3142 T5041 T5039 prep of,dependence
R3143 T5042 T5043 det the,retina
R3144 T5043 T5041 pobj retina,of
R3145 T5044 T5043 amod neuronal,retina
R3146 T5045 T5043 punct (,retina
R3147 T5046 T5043 cc and,retina
R3148 T5047 T5043 conj brain,retina
R3149 T5048 T5039 punct ),dependence
R3150 T5049 T5039 prep on,dependence
R3151 T5050 T5049 pobj glucose,on
R3152 T5051 T5039 prep as,dependence
R3153 T5052 T5053 det the,source
R3154 T5053 T5051 pobj source,as
R3155 T5054 T5053 amod main,source
R3156 T5055 T5053 compound substrate,source
R3157 T5056 T5053 prep for,source
R3158 T5057 T5058 compound energy,production
R3159 T5058 T5056 pobj production,for
R3160 T5059 T5039 punct ", ",dependence
R3161 T5060 T5039 cc and,dependence
R3162 T5061 T5062 det the,impact
R3163 T5062 T5039 conj impact,dependence
R3164 T5063 T5062 amod determinant,impact
R3165 T5064 T5062 prep of,impact
R3166 T5065 T5066 amod metabolic,disorders
R3167 T5066 T5064 pobj disorders,of
R3168 T5067 T5066 punct ", ",disorders
R3169 T5068 T5066 prep such,disorders
R3170 T5069 T5068 pcomp as,such
R3171 T5070 T5068 pobj diabetes,such
R3172 T5071 T5062 punct ", ",impact
R3173 T5072 T5062 prep in,impact
R3174 T5073 T5074 amod retinal,function
R3175 T5074 T5072 pobj function,in
R3176 T5075 T5062 punct (,impact
R3177 T5076 T5077 advmod e.g.,retinopathy
R3178 T5077 T5062 appos retinopathy,impact
R3179 T5078 T5077 punct ", ",retinopathy
R3180 T5079 T5077 amod diabetic,retinopathy
R3181 T5080 T5062 punct ),impact
R3182 T5081 T5082 punct [,37
R3183 T5082 T5062 parataxis 37,impact
R3184 T5083 T5082 punct ],37
R3185 T5084 T5019 punct ", ",probed
R3186 T5085 T5019 nsubj we,probed
R3187 T5086 T5087 det the,impact
R3188 T5087 T5019 dobj impact,probed
R3189 T5088 T5087 prep of,impact
R3190 T5089 T5088 pobj deficits,of
R3191 T5090 T5089 prep in,deficits
R3192 T5091 T5090 pobj RanBP2,in
R3193 T5092 T5091 punct ", ",RanBP2
R3194 T5093 T5091 conj HKI,RanBP2
R3195 T5094 T5093 punct ", ",HKI
R3196 T5095 T5093 cc and,HKI
R3197 T5096 T5093 conj ATP,HKI
R3198 T5097 T5087 punct ", ",impact
R3199 T5098 T5087 prep on,impact
R3200 T5099 T5100 det the,responses
R3201 T5100 T5098 pobj responses,on
R3202 T5101 T5100 amod electrophysiological,responses
R3203 T5102 T5100 prep of,responses
R3204 T5103 T5104 nmod subclasses,neurons
R3205 T5104 T5102 pobj neurons,of
R3206 T5105 T5103 punct (,subclasses
R3207 T5106 T5103 appos rod,subclasses
R3208 T5107 T5106 cc and,rod
R3209 T5108 T5106 conj cone,rod
R3210 T5109 T5103 punct ),subclasses
R3211 T5110 T5104 nmod photoreceptor,neurons
R3212 T5111 T5110 cc and,photoreceptor
R3213 T5112 T5110 conj postreceptor,photoreceptor
R3214 T5113 T5104 amod retinal,neurons
R3215 T5114 T5104 prep of,neurons
R3216 T5115 T5114 pobj RanBP2,of
R3217 T5116 T5115 punct +,RanBP2
R3218 T5117 T5115 punct /,RanBP2
R3219 T5118 T5115 punct −,RanBP2
R3220 T5119 T5098 cc and,on
R3221 T5120 T5098 conj in,on
R3222 T5121 T5122 nmod RanBP2,mice
R3223 T5122 T5120 pobj mice,in
R3224 T5123 T5121 punct +,RanBP2
R3225 T5124 T5121 punct /,RanBP2
R3226 T5125 T5121 punct +,RanBP2
R3227 T5126 T5019 punct .,probed
R3228 T5128 T5129 det The,responses
R3229 T5129 T5136 nsubjpass responses,reduced
R3230 T5130 T5129 amod scotopic,responses
R3231 T5131 T5132 punct (,adapted
R3232 T5132 T5130 parataxis adapted,scotopic
R3233 T5133 T5132 npadvmod dark,adapted
R3234 T5134 T5132 punct -,adapted
R3235 T5135 T5132 punct ),adapted
R3236 T5137 T5129 acl mediated,responses
R3237 T5138 T5137 agent by,mediated
R3238 T5139 T5140 det the,pathway
R3239 T5140 T5138 pobj pathway,by
R3240 T5141 T5142 compound rod,photoreceptor
R3241 T5142 T5140 compound photoreceptor,pathway
R3242 T5143 T5140 prep at,pathway
R3243 T5144 T5145 amod low,stimulus
R3244 T5145 T5147 compound stimulus,intensities
R3245 T5146 T5145 punct -,stimulus
R3246 T5147 T5143 pobj intensities,at
R3247 T5148 T5140 cc and,pathway
R3248 T5149 T5150 amod mixed,pathways
R3249 T5150 T5140 conj pathways,pathway
R3250 T5151 T5150 nmod rod,pathways
R3251 T5152 T5151 cc and,rod
R3252 T5153 T5151 conj cone,rod
R3253 T5154 T5150 prep at,pathways
R3254 T5155 T5156 amod high,stimulus
R3255 T5156 T5158 compound stimulus,intensities
R3256 T5157 T5156 punct -,stimulus
R3257 T5158 T5154 pobj intensities,at
R3258 T5159 T5136 auxpass were,reduced
R3259 T5160 T5136 advmod substantially,reduced
R3260 T5161 T5136 prep in,reduced
R3261 T5162 T5163 nmod RanBP2,mice
R3262 T5163 T5161 pobj mice,in
R3263 T5164 T5162 punct +,RanBP2
R3264 T5165 T5162 punct /,RanBP2
R3265 T5166 T5162 punct −,RanBP2
R3266 T5167 T5168 punct (,8A
R3267 T5168 T5136 parataxis 8A,reduced
R3268 T5169 T5168 compound Figure,8A
R3269 T5170 T5168 punct ),8A
R3270 T5171 T5136 punct .,reduced
R3271 T5173 T5174 det The,differences
R3272 T5174 T5175 nsubj differences,were
R3273 T5176 T5174 prep in,differences
R3274 T5177 T5178 det the,responses
R3275 T5178 T5176 pobj responses,in
R3276 T5179 T5178 amod photopic,responses
R3277 T5180 T5181 punct (,adapted
R3278 T5181 T5179 parataxis adapted,photopic
R3279 T5182 T5181 npadvmod light,adapted
R3280 T5183 T5181 punct -,adapted
R3281 T5184 T5181 punct ),adapted
R3282 T5185 T5178 punct ", ",responses
R3283 T5186 T5178 acl initiated,responses
R3284 T5187 T5186 agent by,initiated
R3285 T5188 T5189 compound cone,photoreceptors
R3286 T5189 T5187 pobj photoreceptors,by
R3287 T5190 T5189 punct ", ",photoreceptors
R3288 T5191 T5192 dep which,make
R3289 T5192 T5189 relcl make,photoreceptors
R3290 T5193 T5192 prt up,make
R3291 T5194 T5195 nummod 3,%
R3292 T5195 T5192 dobj %,make
R3293 T5196 T5195 prep of,%
R3294 T5197 T5198 det the,neurons
R3295 T5198 T5196 pobj neurons,of
R3296 T5199 T5198 amod photosensory,neurons
R3297 T5200 T5198 prep in,neurons
R3298 T5201 T5202 det the,retina
R3299 T5202 T5200 pobj retina,in
R3300 T5203 T5202 compound mouse,retina
R3301 T5204 T5205 punct [,38
R3302 T5205 T5174 parataxis 38,differences
R3303 T5206 T5205 punct ],38
R3304 T5207 T5175 punct ", ",were
R3305 T5208 T5209 advmod less,obvious
R3306 T5209 T5175 acomp obvious,were
R3307 T5210 T5175 cc but,were
R3308 T5211 T5212 advmod still,exhibited
R3309 T5212 T5175 conj exhibited,were
R3310 T5213 T5214 det a,trend
R3311 T5214 T5212 dobj trend,exhibited
R3312 T5215 T5214 prep toward,trend
R3313 T5216 T5217 amod reduced,amplitudes
R3314 T5217 T5215 pobj amplitudes,toward
R3315 T5218 T5214 prep across,trend
R3316 T5219 T5220 det a,range
R3317 T5220 T5218 pobj range,across
R3318 T5221 T5220 prep of,range
R3319 T5222 T5223 amod increasing,intensities
R3320 T5223 T5221 pobj intensities,of
R3321 T5224 T5225 amod light,stimulus
R3322 T5225 T5223 compound stimulus,intensities
R3323 T5226 T5227 punct (,8B
R3324 T5227 T5212 parataxis 8B,exhibited
R3325 T5228 T5227 compound Figure,8B
R3326 T5229 T5227 punct ),8B
R3327 T5230 T5175 punct .,were
R3328 T5232 T5233 det The,reduction
R3329 T5233 T5234 nsubj reduction,included
R3330 T5235 T5233 prep in,reduction
R3331 T5236 T5237 det the,responses
R3332 T5237 T5235 pobj responses,in
R3333 T5238 T5237 amod scotopic,responses
R3334 T5239 T5234 dobj decreases,included
R3335 T5240 T5239 prep in,decreases
R3336 T5241 T5242 preconj both,wave
R3337 T5242 T5245 nmod wave,amplitudes
R3338 T5243 T5242 nmod b,wave
R3339 T5244 T5242 punct -,wave
R3340 T5245 T5240 pobj amplitudes,in
R3341 T5246 T5247 punct (,8C
R3342 T5247 T5242 parataxis 8C,wave
R3343 T5248 T5247 compound Figure,8C
R3344 T5249 T5247 punct ),8C
R3345 T5250 T5242 cc and,wave
R3346 T5251 T5252 compound a,wave
R3347 T5252 T5242 conj wave,wave
R3348 T5253 T5252 punct -,wave
R3349 T5254 T5255 punct (,8D
R3350 T5255 T5252 parataxis 8D,wave
R3351 T5256 T5255 compound Figure,8D
R3352 T5257 T5255 punct ),8D
R3353 T5258 T5245 acl mediated,amplitudes
R3354 T5259 T5258 agent by,mediated
R3355 T5260 T5261 amod postreceptoral,neurons
R3356 T5261 T5259 pobj neurons,by
R3357 T5262 T5260 cc and,postreceptoral
R3358 T5263 T5260 conj receptoral,postreceptoral
R3359 T5264 T5234 punct ", ",included
R3360 T5265 T5234 advmod respectively,included
R3361 T5266 T5234 punct .,included
R3362 T5268 T5269 amod Postreceptoral,responses
R3363 T5269 T5274 nsubj responses,tended
R3364 T5270 T5271 amod second,order
R3365 T5271 T5269 compound order,responses
R3366 T5272 T5271 punct -,order
R3367 T5273 T5269 compound neuron,responses
R3368 T5275 T5269 punct ", ",responses
R3369 T5276 T5269 acl represented,responses
R3370 T5277 T5276 agent by,represented
R3371 T5278 T5279 det the,wave
R3372 T5279 T5277 pobj wave,by
R3373 T5280 T5279 compound b,wave
R3374 T5281 T5279 punct -,wave
R3375 T5282 T5274 punct ", ",tended
R3376 T5283 T5284 aux to,be
R3377 T5284 T5274 xcomp be,tended
R3378 T5285 T5286 advmod more,reduced
R3379 T5286 T5284 acomp reduced,be
R3380 T5287 T5285 advmod consistently,more
R3381 T5288 T5287 cc and,consistently
R3382 T5289 T5287 conj substantially,consistently
R3383 T5290 T5286 prep than,reduced
R3384 T5291 T5292 det the,waves
R3385 T5292 T5290 pobj waves,than
R3386 T5293 T5292 compound a,waves
R3387 T5294 T5292 punct -,waves
R3388 T5295 T5292 punct ", ",waves
R3389 T5296 T5297 dep which,reflect
R3390 T5297 T5292 relcl reflect,waves
R3391 T5298 T5297 advmod directly,reflect
R3392 T5299 T5300 compound photoreceptor,activity
R3393 T5300 T5297 dobj activity,reflect
R3394 T5301 T5274 punct .,tended
R3395 T5303 T5304 mark Since,depend
R3396 T5304 T5310 advcl depend,suggests
R3397 T5305 T5306 amod second,order
R3398 T5306 T5308 compound order,responses
R3399 T5307 T5306 punct -,order
R3400 T5308 T5304 nsubj responses,depend
R3401 T5309 T5308 compound neuron,responses
R3402 T5311 T5304 prep on,depend
R3403 T5312 T5311 pobj input,on
R3404 T5313 T5312 prep from,input
R3405 T5314 T5313 pobj photoreceptors,from
R3406 T5315 T5310 punct ", ",suggests
R3407 T5316 T5310 nsubj this,suggests
R3408 T5317 T5318 mark that,are
R3409 T5318 T5310 ccomp are,suggests
R3410 T5319 T5320 amod reduced,amplitudes
R3411 T5320 T5318 nsubj amplitudes,are
R3412 T5321 T5322 compound b,wave
R3413 T5322 T5320 compound wave,amplitudes
R3414 T5323 T5322 punct -,wave
R3415 T5324 T5325 det the,result
R3416 T5325 T5318 attr result,are
R3417 T5326 T5325 prep of,result
R3418 T5327 T5328 det the,accumulation
R3419 T5328 T5326 pobj accumulation,of
R3420 T5329 T5328 prep of,accumulation
R3421 T5330 T5329 pobj decreases,of
R3422 T5331 T5330 prep in,decreases
R3423 T5332 T5333 det the,response
R3424 T5333 T5331 pobj response,in
R3425 T5334 T5333 amod light,response
R3426 T5335 T5333 prep of,response
R3427 T5336 T5337 preconj both,photoreceptors
R3428 T5337 T5335 pobj photoreceptors,of
R3429 T5338 T5337 cc and,photoreceptors
R3430 T5339 T5340 amod postreceptoral,neurons
R3431 T5340 T5337 conj neurons,photoreceptors
R3432 T5341 T5310 punct .,suggests
R3433 T5343 T5344 nsubj Anesthetics,cause
R3434 T5345 T5343 punct ", ",Anesthetics
R3435 T5346 T5347 advmod particularly,ketamine
R3436 T5347 T5343 appos ketamine,Anesthetics
R3437 T5348 T5344 punct ", ",cause
R3438 T5349 T5344 aux can,cause
R3439 T5350 T5351 amod sustained,elevation
R3440 T5351 T5344 dobj elevation,cause
R3441 T5352 T5351 prep of,elevation
R3442 T5353 T5352 pobj glucose,of
R3443 T5354 T5351 prep in,elevation
R3444 T5355 T5354 pobj mice,in
R3445 T5356 T5351 punct ", ",elevation
R3446 T5357 T5358 dep which,affects
R3447 T5358 T5351 relcl affects,elevation
R3448 T5359 T5358 prep in,affects
R3449 T5360 T5359 pobj turn,in
R3450 T5361 T5362 compound electroretinogram,responses
R3451 T5362 T5358 dobj responses,affects
R3452 T5363 T5364 punct [,39
R3453 T5364 T5358 parataxis 39,affects
R3454 T5365 T5364 punct ],39
R3455 T5366 T5344 punct .,cause
R3456 T5368 T5369 advmod Thus,were
R3457 T5370 T5369 punct ", ",were
R3458 T5371 T5369 nsubj we,were
R3459 T5372 T5369 acomp concerned,were
R3460 T5373 T5374 mark that,reflect
R3461 T5374 T5372 ccomp reflect,concerned
R3462 T5375 T5374 nsubj differences,reflect
R3463 T5376 T5375 prep in,differences
R3464 T5377 T5378 compound electroretinogram,amplitudes
R3465 T5378 T5376 pobj amplitudes,in
R3466 T5379 T5375 prep between,differences
R3467 T5380 T5379 pobj RanBP2,between
R3468 T5381 T5380 punct +,RanBP2
R3469 T5382 T5380 punct /,RanBP2
R3470 T5383 T5380 punct −,RanBP2
R3471 T5384 T5380 cc and,RanBP2
R3472 T5385 T5380 conj RanBP2,RanBP2
R3473 T5386 T5385 punct +,RanBP2
R3474 T5387 T5385 punct /,RanBP2
R3475 T5388 T5385 punct +,RanBP2
R3476 T5389 T5374 aux may,reflect
R3477 T5390 T5374 dobj differences,reflect
R3478 T5391 T5390 prep in,differences
R3479 T5392 T5393 compound glucose,level
R3480 T5393 T5394 compound level,changes
R3481 T5394 T5391 pobj changes,in
R3482 T5395 T5394 prep in,changes
R3483 T5396 T5395 pobj response,in
R3484 T5397 T5396 prep to,response
R3485 T5398 T5397 pobj anesthesia,to
R3486 T5399 T5369 punct .,were
R3487 T5401 T5402 advmod However,found
R3488 T5403 T5402 punct ", ",found
R3489 T5404 T5402 nsubj we,found
R3490 T5405 T5406 det no,differences
R3491 T5406 T5402 dobj differences,found
R3492 T5407 T5406 amod significant,differences
R3493 T5408 T5406 prep in,differences
R3494 T5409 T5410 compound glucose,levels
R3495 T5410 T5408 pobj levels,in
R3496 T5411 T5410 acl measured,levels
R3497 T5412 T5411 prep before,measured
R3498 T5413 T5411 cc and,measured
R3499 T5414 T5415 det every,min
R3500 T5415 T5417 npadvmod min,during
R3501 T5416 T5415 nummod 15,min
R3502 T5417 T5418 prep during,min
R3503 T5418 T5411 conj min,measured
R3504 T5419 T5418 nummod 75,min
R3505 T5420 T5418 prep of,min
R3506 T5421 T5420 pobj anesthesia,of
R3507 T5422 T5423 punct (,5
R3508 T5423 T5402 parataxis 5,found
R3509 T5424 T5423 nsubj n,5
R3510 T5425 T5423 punct =,5
R3511 T5426 T5423 quantmod 4,5
R3512 T5427 T5423 punct –,5
R3513 T5428 T5423 punct ),5
R3514 T5429 T5402 punct .,found
R3515 T5431 T5432 nsubj Glucose,rose
R3516 T5433 T5432 prep at,rose
R3517 T5434 T5435 det the,rate
R3518 T5435 T5433 pobj rate,at
R3519 T5436 T5435 amod same,rate
R3520 T5437 T5432 cc and,rose
R3521 T5438 T5432 conj reached,rose
R3522 T5439 T5440 det a,maximum
R3523 T5440 T5438 dobj maximum,reached
R3524 T5441 T5440 prep of,maximum
R3525 T5442 T5443 advmod approximately,3.3
R3526 T5443 T5444 nummod 3.3,level
R3527 T5444 T5441 pobj level,of
R3528 T5445 T5443 quantmod times,3.3
R3529 T5446 T5444 det the,level
R3530 T5447 T5444 amod pre-anesthesia,level
R3531 T5448 T5438 prep in,reached
R3532 T5449 T5450 det both,genotypes
R3533 T5450 T5448 pobj genotypes,in
R3534 T5451 T5452 punct (,data
R3535 T5452 T5438 meta data,reached
R3536 T5453 T5452 amod unpublished,data
R3537 T5454 T5452 punct ),data
R3538 T5455 T5432 punct .,rose
R7150 T10852 T10853 det The,LD
R7151 T10853 T10854 nsubj LD,Interacts
R7152 T10855 T10853 prep of,LD
R7153 T10856 T10855 pobj RanBP2,of
R7154 T10857 T10854 prep with,Interacts
R7155 T10858 T10857 pobj Cox11,with
R7156 T10859 T10858 cc and,Cox11
R7157 T10860 T10858 conj HKI,Cox11
R7158 T10862 T10863 punct (,A
R7159 T10863 T10864 meta A,structure
R7160 T10865 T10863 punct ),A
R7161 T10866 T10864 amod Primary,structure
R7162 T10867 T10864 prep of,structure
R7163 T10868 T10867 pobj RanBP2,of
R7164 T10869 T10864 cc and,structure
R7165 T10870 T10871 poss its,domains
R7166 T10871 T10864 conj domains,structure
R7167 T10872 T10873 amod structural,functional
R7168 T10873 T10871 amod functional,domains
R7169 T10874 T10873 punct /,functional
R7170 T10875 T10871 punct .,domains
R7171 T10877 T10878 det The,LD
R7172 T10878 T10882 nsubjpass LD,underlined
R7173 T10879 T10880 npadvmod N,terminal
R7174 T10880 T10878 amod terminal,LD
R7175 T10881 T10880 punct -,terminal
R7176 T10883 T10878 prep of,LD
R7177 T10884 T10883 pobj RanBP2,of
R7178 T10885 T10882 auxpass is,underlined
R7179 T10886 T10882 punct .,underlined
R7180 T10888 T10889 punct (,B
R7181 T10889 T10890 meta B,alignment
R7182 T10891 T10889 punct ),B
R7183 T10892 T10890 compound Sequence,alignment
R7184 T10893 T10890 prep of,alignment
R7185 T10894 T10895 amod murine,Cox11
R7186 T10895 T10893 pobj Cox11,of
R7187 T10896 T10894 cc and,murine
R7188 T10897 T10894 conj yeast,murine
R7189 T10898 T10890 punct .,alignment
R7190 T10900 T10901 det The,domains
R7191 T10901 T10910 nsubjpass domains,conserved
R7192 T10902 T10901 nmod yeast,domains
R7193 T10903 T10901 nmod Cox11,domains
R7194 T10904 T10905 npadvmod C,terminal
R7195 T10905 T10901 amod terminal,domains
R7196 T10906 T10904 punct -,C
R7197 T10907 T10904 cc and,C
R7198 T10908 T10904 conj N,C
R7199 T10909 T10905 punct -,terminal
R7200 T10911 T10910 auxpass are,conserved
R7201 T10912 T10910 advmod poorly,conserved
R7202 T10913 T10910 punct .,conserved
R7203 T10915 T10916 nsubj Arrow,denote
R7204 T10917 T10915 cc and,Arrow
R7205 T10918 T10919 amod solid,line
R7206 T10919 T10915 conj line,Arrow
R7207 T10920 T10921 det the,site
R7208 T10921 T10916 dobj site,denote
R7209 T10922 T10921 amod predicted,site
R7210 T10923 T10924 amod mitochondrial,cleavage
R7211 T10924 T10921 compound cleavage,site
R7212 T10925 T10921 cc and,site
R7213 T10926 T10927 npadvmod membrane,spanning
R7214 T10927 T10929 amod spanning,domain
R7215 T10928 T10927 punct -,spanning
R7216 T10929 T10921 conj domain,site
R7217 T10930 T10916 punct .,denote
R7218 T10932 T10933 det The,lines
R7219 T10933 T10937 nsubj lines,represent
R7220 T10934 T10933 amod dotted,lines
R7221 T10935 T10934 cc and,dotted
R7222 T10936 T10934 conj dashed,dotted
R7223 T10938 T10933 prep above,lines
R7224 T10939 T10940 det the,sequences
R7225 T10940 T10938 pobj sequences,above
R7226 T10941 T10940 amod aligned,sequences
R7227 T10942 T10937 punct ", ",represent
R7228 T10943 T10937 advmod respectively,represent
R7229 T10944 T10937 punct ", ",represent
R7230 T10945 T10946 nmod Cox11,N
R7231 T10946 T10948 nmod N,constructs
R7232 T10947 T10946 punct -,N
R7233 T10948 T10937 dobj constructs,represent
R7234 T10949 T10946 cc and,N
R7235 T10950 T10951 compound Cox11,C
R7236 T10951 T10946 conj C,N
R7237 T10952 T10951 punct -,C
R7238 T10953 T10948 acl shown,constructs
R7239 T10954 T10953 prep in,shown
R7240 T10955 T10956 compound Figure,1C
R7241 T10956 T10954 pobj 1C,in
R7242 T10957 T10937 punct .,represent
R7243 T10959 T10960 punct (,C
R7244 T10960 T10961 meta C,analysis
R7245 T10962 T10960 punct ),C
R7246 T10963 T10964 compound Structure,function
R7247 T10964 T10961 compound function,analysis
R7248 T10965 T10964 punct -,function
R7249 T10966 T10961 prep of,analysis
R7250 T10967 T10968 det the,interaction
R7251 T10968 T10966 pobj interaction,of
R7252 T10969 T10968 prep between,interaction
R7253 T10970 T10971 det the,LD
R7254 T10971 T10969 pobj LD,between
R7255 T10972 T10971 prep of,LD
R7256 T10973 T10972 pobj RanBP2,of
R7257 T10974 T10971 cc and,LD
R7258 T10975 T10971 conj Cox11,LD
R7259 T10976 T10961 punct .,analysis
R7260 T10978 T10979 amod Optimal,interaction
R7261 T10979 T10980 nsubj interaction,occurred
R7262 T10981 T10979 prep between,interaction
R7263 T10982 T10983 det the,LD
R7264 T10983 T10981 pobj LD,between
R7265 T10984 T10983 cc and,LD
R7266 T10985 T10983 conj Cox11,LD
R7267 T10986 T10980 prep in,occurred
R7268 T10987 T10988 det the,presence
R7269 T10988 T10986 pobj presence,in
R7270 T10989 T10988 prep of,presence
R7271 T10990 T10989 pobj constructs,of
R7272 T10991 T10990 acl comprising,constructs
R7273 T10992 T10993 preconj both,LD
R7274 T10993 T10991 dobj LD,comprising
R7275 T10994 T10993 det the,LD
R7276 T10995 T10993 amod complete,LD
R7277 T10996 T10993 cc and,LD
R7278 T10997 T10993 conj Cox11,LD
R7279 T10998 T10980 punct .,occurred
R7280 T11000 T11001 mark Although,decreased
R7281 T11001 T11015 advcl decreased,retained
R7282 T11002 T11001 nsubj removal,decreased
R7283 T11003 T11002 prep of,removal
R7284 T11004 T11005 det the,N
R7285 T11005 T11003 pobj N,of
R7286 T11006 T11005 amod cytosolic,N
R7287 T11007 T11005 punct -,N
R7288 T11008 T11005 amod terminal,N
R7289 T11009 T11002 punct (,removal
R7290 T11010 T11011 compound Cox11,C
R7291 T11011 T11002 appos C,removal
R7292 T11012 T11011 punct -,C
R7293 T11013 T11001 punct ),decreased
R7294 T11014 T11001 advmod significantly,decreased
R7295 T11016 T11017 det the,interaction
R7296 T11017 T11001 dobj interaction,decreased
R7297 T11018 T11017 prep with,interaction
R7298 T11019 T11018 pobj LD,with
R7299 T11020 T11015 punct ", ",retained
R7300 T11021 T11022 det the,domain
R7301 T11022 T11015 nsubj domain,retained
R7302 T11023 T11022 amod mitochondrial,domain
R7303 T11024 T11022 compound intermembrane,domain
R7304 T11025 T11022 prep of,domain
R7305 T11026 T11025 pobj Cox11,of
R7306 T11027 T11022 punct (,domain
R7307 T11028 T11029 compound Cox11,C
R7308 T11029 T11022 appos C,domain
R7309 T11030 T11029 punct -,C
R7310 T11031 T11022 punct ),domain
R7311 T11032 T11022 advmod together,domain
R7312 T11033 T11032 prep with,together
R7313 T11034 T11035 det the,half
R7314 T11035 T11033 pobj half,with
R7315 T11036 T11037 npadvmod C,terminal
R7316 T11037 T11035 amod terminal,half
R7317 T11038 T11037 punct -,terminal
R7318 T11039 T11035 prep of,half
R7319 T11040 T11039 pobj LD,of
R7320 T11041 T11035 punct (,half
R7321 T11042 T11043 compound LD,C
R7322 T11043 T11035 appos C,half
R7323 T11044 T11043 punct -,C
R7324 T11045 T11015 punct ),retained
R7325 T11046 T11015 dobj most,retained
R7326 T11047 T11046 prep of,most
R7327 T11048 T11049 det the,activity
R7328 T11049 T11047 pobj activity,of
R7329 T11050 T11049 compound interaction,activity
R7330 T11051 T11015 punct .,retained
R7331 T11053 T11054 compound LD,N
R7332 T11054 T11056 nsubj N,ended
R7333 T11055 T11054 punct -,N
R7334 T11057 T11054 cc and,N
R7335 T11058 T11059 compound LD,C
R7336 T11059 T11054 conj C,N
R7337 T11060 T11059 punct -,C
R7338 T11061 T11056 cc and,ended
R7339 T11062 T11056 conj began,ended
R7340 T11063 T11062 prep with,began
R7341 T11064 T11065 det the,domain
R7342 T11065 T11063 pobj domain,with
R7343 T11066 T11067 compound leucine,zipper
R7344 T11067 T11065 compound zipper,domain
R7345 T11068 T11065 prep of,domain
R7346 T11069 T11068 pobj RanBP2,of
R7347 T11070 T11056 punct .,ended
R7348 T11072 T11073 amod White,bars
R7349 T11073 T11076 nsubj bars,denote
R7350 T11074 T11072 cc and,White
R7351 T11075 T11072 conj black,White
R7352 T11077 T11078 compound β,galactosidase
R7353 T11078 T11080 compound galactosidase,activity
R7354 T11079 T11078 punct -,galactosidase
R7355 T11080 T11076 dobj activity,denote
R7356 T11081 T11080 cc and,activity
R7357 T11082 T11083 compound growth,rates
R7358 T11083 T11080 conj rates,activity
R7359 T11084 T11083 prep in,rates
R7360 T11085 T11086 amod selective,medium
R7361 T11086 T11084 pobj medium,in
R7362 T11087 T11086 compound growth,medium
R7363 T11088 T11076 punct ", ",denote
R7364 T11089 T11076 advmod respectively,denote
R7365 T11090 T11076 punct .,denote
R7366 T11092 T11093 nsubj Results,represent
R7367 T11093 T11095 ccomp represent,3
R7368 T11094 T11092 acl shown,Results
R7369 T11096 T11097 det the,SD
R7370 T11097 T11093 dobj SD,represent
R7371 T11098 T11097 nmod mean,SD
R7372 T11099 T11097 punct ±,SD
R7373 T11100 T11095 punct ", ",3
R7374 T11101 T11095 nsubj n,3
R7375 T11102 T11095 punct =,3
R7376 T11103 T11095 punct .,3
R7377 T11105 T11106 punct (,D
R7378 T11106 T11107 meta D,assays
R7379 T11108 T11106 punct ),D
R7380 T11109 T11107 nmod GST,assays
R7381 T11110 T11107 amod pull,assays
R7382 T11111 T11110 punct -,pull
R7383 T11112 T11110 prt down,pull
R7384 T11113 T11107 prep with,assays
R7385 T11114 T11115 det the,LD
R7386 T11115 T11113 pobj LD,with
R7387 T11116 T11115 prep of,LD
R7388 T11117 T11116 pobj RanBP2,of
R7389 T11118 T11115 cc and,LD
R7390 T11119 T11120 poss its,domain
R7391 T11120 T11115 conj domain,LD
R7392 T11121 T11122 compound leucine,zipper
R7393 T11122 T11120 compound zipper,domain
R7394 T11123 T11120 cc and,domain
R7395 T11124 T11125 amod retinal,extracts
R7396 T11125 T11120 conj extracts,domain
R7397 T11126 T11107 punct .,assays
R7398 T11128 T11129 det The,LD
R7399 T11129 T11130 nsubj LD,associate
R7400 T11131 T11129 punct ", ",LD
R7401 T11132 T11129 cc but,LD
R7402 T11133 T11132 neg not,but
R7403 T11134 T11135 det the,domain
R7404 T11135 T11129 conj domain,LD
R7405 T11136 T11137 compound leucine,zipper
R7406 T11137 T11135 compound zipper,domain
R7407 T11138 T11129 prep of,LD
R7408 T11139 T11138 pobj RanBP2,of
R7409 T11140 T11130 punct ", ",associate
R7410 T11141 T11130 prep with,associate
R7411 T11142 T11141 pobj Cox11,with
R7412 T11143 T11144 punct (,lane
R7413 T11144 T11142 parataxis lane,Cox11
R7414 T11145 T11146 amod top,panel
R7415 T11146 T11144 dep panel,lane
R7416 T11147 T11144 punct ", ",lane
R7417 T11148 T11144 nummod 1,lane
R7418 T11149 T11144 punct ),lane
R7419 T11150 T11142 cc and,Cox11
R7420 T11151 T11142 conj HKI,Cox11
R7421 T11152 T11153 punct (,lane
R7422 T11153 T11151 parataxis lane,HKI
R7423 T11154 T11155 amod bottom,panel
R7424 T11155 T11153 dep panel,lane
R7425 T11156 T11153 punct ", ",lane
R7426 T11157 T11153 nummod 1,lane
R7427 T11158 T11153 punct ),lane
R7428 T11159 T11130 punct .,associate
R7429 T11161 T11162 punct (,E
R7430 T11162 T11163 meta E,shows
R7431 T11164 T11162 punct ),E
R7432 T11165 T11163 nsubj Coimmunoprecipitation,shows
R7433 T11166 T11165 prep of,Coimmunoprecipitation
R7434 T11167 T11166 pobj RanBP2,of
R7435 T11168 T11165 prep with,Coimmunoprecipitation
R7436 T11169 T11168 pobj antibodies,with
R7437 T11170 T11169 prep against,antibodies
R7438 T11171 T11172 poss its,partners
R7439 T11172 T11170 pobj partners,against
R7440 T11173 T11172 amod molecular,partners
R7441 T11174 T11175 mark that,forms
R7442 T11175 T11163 ccomp forms,shows
R7443 T11176 T11175 nsubj RanBP2,forms
R7444 T11177 T11178 det a,complex
R7445 T11178 T11175 dobj complex,forms
R7446 T11179 T11180 advmod in,vivo
R7447 T11180 T11175 advmod vivo,forms
R7448 T11181 T11175 prep with,forms
R7449 T11182 T11181 pobj HKI,with
R7450 T11183 T11184 punct (,1
R7451 T11184 T11182 parataxis 1,HKI
R7452 T11185 T11184 nmod lanes,1
R7453 T11186 T11184 cc and,1
R7454 T11187 T11184 conj 2,1
R7455 T11188 T11184 punct ),1
R7456 T11189 T11182 punct ", ",HKI
R7457 T11190 T11182 conj mHsp70,HKI
R7458 T11191 T11192 punct (,lane
R7459 T11192 T11190 parataxis lane,mHsp70
R7460 T11193 T11192 nummod 3,lane
R7461 T11194 T11192 punct ),lane
R7462 T11195 T11190 punct ", ",mHsp70
R7463 T11196 T11190 cc and,mHsp70
R7464 T11197 T11190 conj Cox11,mHsp70
R7465 T11198 T11199 punct (,lane
R7466 T11199 T11197 parataxis lane,Cox11
R7467 T11200 T11199 nummod 4,lane
R7468 T11201 T11199 punct ),lane
R7469 T11202 T11163 punct .,shows
R7470 T11204 T11205 nmod Lanes,5
R7471 T11205 T11206 nsubj 5,are
R7472 T11207 T11205 punct ", ",5
R7473 T11208 T11205 conj 6,5
R7474 T11209 T11208 punct ", ",6
R7475 T11210 T11208 cc and,6
R7476 T11211 T11208 conj 7,6
R7477 T11212 T11213 compound control,reactions
R7478 T11213 T11206 attr reactions,are
R7479 T11214 T11213 compound immunoprecipitation,reactions
R7480 T11215 T11213 prep with,reactions
R7481 T11216 T11217 amod different,antibodies
R7482 T11217 T11215 pobj antibodies,with
R7483 T11218 T11217 prep against,antibodies
R7484 T11219 T11220 det the,domains
R7485 T11220 T11218 pobj domains,against
R7486 T11221 T11220 compound RanBP2,domains
R7487 T11222 T11220 punct ", ",domains
R7488 T11223 T11220 appos KBD,domains
R7489 T11224 T11223 punct ", ",KBD
R7490 T11225 T11223 conj ZnF,KBD
R7491 T11226 T11225 punct ", ",ZnF
R7492 T11227 T11225 cc and,ZnF
R7493 T11228 T11225 conj XAFXFG,ZnF
R7494 T11229 T11220 prep of,domains
R7495 T11230 T11229 pobj nucleoporins,of
R7496 T11231 T11206 punct .,are
R7497 T11233 T11234 punct (,F
R7498 T11234 T11235 meta F,coimmunoprecipitation
R7499 T11236 T11234 punct ),F
R7500 T11237 T11235 amod Reciprocal,coimmunoprecipitation
R7501 T11238 T11235 prep of,coimmunoprecipitation
R7502 T11239 T11238 pobj HKI,of
R7503 T11240 T11235 prep with,coimmunoprecipitation
R7504 T11241 T11240 pobj antibodies,with
R7505 T11242 T11241 prep against,antibodies
R7506 T11243 T11242 pobj RanBP2,against
R7507 T11244 T11241 punct (,antibodies
R7508 T11245 T11241 acl used,antibodies
R7509 T11246 T11245 cc and,used
R7510 T11247 T11245 conj shown,used
R7511 T11248 T11247 prep in,shown
R7512 T11249 T11248 punct (,in
R7513 T11250 T11248 pobj E,in
R7514 T11251 T11235 punct ),coimmunoprecipitation
R7515 T11252 T11235 punct ),coimmunoprecipitation
R7516 T11253 T11235 punct .,coimmunoprecipitation
R7517 T11255 T11256 punct (,G
R7518 T11256 T11257 meta G,assays
R7519 T11258 T11256 punct ),G
R7520 T11259 T11257 nmod Reconstitution,assays
R7521 T11260 T11257 amod pull,assays
R7522 T11261 T11260 punct -,pull
R7523 T11262 T11260 prt down,pull
R7524 T11263 T11257 prep with,assays
R7525 T11264 T11265 amod purified,LD
R7526 T11265 T11263 pobj LD,with
R7527 T11266 T11265 cc and,LD
R7528 T11267 T11268 amod increasing,concentrations
R7529 T11268 T11265 conj concentrations,LD
R7530 T11269 T11268 prep of,concentrations
R7531 T11270 T11271 amod native,Cox11
R7532 T11271 T11269 pobj Cox11,of
R7533 T11272 T11273 punct (,panel
R7534 T11273 T11270 parataxis panel,native
R7535 T11274 T11273 amod top,panel
R7536 T11275 T11273 punct ),panel
R7537 T11276 T11270 punct ", ",native
R7538 T11277 T11270 conj denatured,native
R7539 T11278 T11279 punct (,panel
R7540 T11279 T11277 parataxis panel,denatured
R7541 T11280 T11279 amod middle,panel
R7542 T11281 T11279 punct ),panel
R7543 T11282 T11277 punct ", ",denatured
R7544 T11283 T11277 cc and,denatured
R7545 T11284 T11285 advmod partially,denatured
R7546 T11285 T11277 conj denatured,denatured
R7547 T11286 T11287 punct (,panel
R7548 T11287 T11285 parataxis panel,denatured
R7549 T11288 T11287 amod bottom,panel
R7550 T11289 T11287 punct ),panel
R7551 T11290 T11268 punct ", ",concentrations
R7552 T11291 T11268 advmod respectively,concentrations
R7553 T11292 T11257 punct ", ",assays
R7554 T11293 T11257 prep in,assays
R7555 T11294 T11295 det the,absence
R7556 T11295 T11293 pobj absence,in
R7557 T11296 T11295 cc and,absence
R7558 T11297 T11295 conj presence,absence
R7559 T11298 T11295 prep of,absence
R7560 T11299 T11300 amod denaturating,agent
R7561 T11300 T11298 pobj agent,of
R7562 T11301 T11300 punct ", ",agent
R7563 T11302 T11300 appos GnHCl,agent
R7564 T11303 T11300 cc and,agent
R7565 T11304 T11305 amod chaotropic,agent
R7566 T11305 T11300 conj agent,agent
R7567 T11306 T11305 punct ", ",agent
R7568 T11307 T11305 appos urea,agent
R7569 T11308 T11257 punct .,assays
R7570 T11310 T11311 compound Folding,intermediates
R7571 T11311 T11312 nsubj intermediates,exhibit
R7572 T11313 T11314 punct (,panel
R7573 T11314 T11311 parataxis panel,intermediates
R7574 T11315 T11314 amod lower,panel
R7575 T11316 T11314 punct ),panel
R7576 T11317 T11311 prep of,intermediates
R7577 T11318 T11317 pobj Cox11,of
R7578 T11319 T11320 det the,activity
R7579 T11320 T11312 dobj activity,exhibit
R7580 T11321 T11320 amod highest,activity
R7581 T11322 T11320 compound binding,activity
R7582 T11323 T11320 prep toward,activity
R7583 T11324 T11325 det the,LD
R7584 T11325 T11323 pobj LD,toward
R7585 T11326 T11325 prep of,LD
R7586 T11327 T11326 pobj RanBP2,of
R7587 T11328 T11312 punct .,exhibit
R7588 T11330 T11331 punct (,H
R7589 T11331 T11332 meta H,experiments
R7590 T11333 T11331 punct ),H
R7591 T11334 T11332 amod Similar,experiments
R7592 T11335 T11332 prep as,experiments
R7593 T11336 T11335 prep in,as
R7594 T11337 T11336 punct (,in
R7595 T11338 T11336 pobj G,in
R7596 T11339 T11332 punct ),experiments
R7597 T11340 T11332 prep but,experiments
R7598 T11341 T11340 prep in,but
R7599 T11342 T11343 det the,presence
R7600 T11343 T11341 pobj presence,in
R7601 T11344 T11343 prep of,presence
R7602 T11345 T11346 amod native,Cox11
R7603 T11346 T11344 pobj Cox11,of
R7604 T11347 T11346 acl expressed,Cox11
R7605 T11348 T11347 prep in,expressed
R7606 T11349 T11350 det the,absence
R7607 T11350 T11348 pobj absence,in
R7608 T11351 T11352 punct (,panel
R7609 T11352 T11350 parataxis panel,absence
R7610 T11353 T11352 amod top,panel
R7611 T11354 T11352 punct ),panel
R7612 T11355 T11350 cc or,absence
R7613 T11356 T11350 conj presence,absence
R7614 T11357 T11358 punct (,panel
R7615 T11358 T11356 parataxis panel,presence
R7616 T11359 T11358 amod bottom,panel
R7617 T11360 T11358 punct ),panel
R7618 T11361 T11350 prep of,absence
R7619 T11362 T11361 pobj CuSO4,of
R7620 T11363 T11332 punct .,experiments
R7621 T11365 T11366 det The,isoform
R7622 T11366 T11368 nsubj isoform,has
R7623 T11367 T11366 amod mature,isoform
R7624 T11369 T11366 prep of,isoform
R7625 T11370 T11371 det the,metallochaperone
R7626 T11371 T11369 pobj metallochaperone,of
R7627 T11372 T11373 det an,affinity
R7628 T11373 T11368 dobj affinity,has
R7629 T11374 T11373 amod increased,affinity
R7630 T11375 T11373 prep toward,affinity
R7631 T11376 T11377 det the,LD
R7632 T11377 T11375 pobj LD,toward
R7633 T11378 T11377 prep of,LD
R7634 T11379 T11378 pobj RanBP2,of
R7635 T11380 T11368 punct .,has
R7636 T11383 T11382 punct ", ",LD
R7637 T11384 T11385 npadvmod leucine,rich
R7638 T11385 T11387 amod rich,domain
R7639 T11386 T11385 punct -,rich
R7640 T11387 T11382 appos domain,LD
R7641 T11388 T11382 punct ;,LD
R7642 T11389 T11382 appos LZ,LD
R7643 T11390 T11389 punct ", ",LZ
R7644 T11391 T11392 compound leucine,zipper
R7645 T11392 T11393 compound zipper,domain
R7646 T11393 T11389 appos domain,LZ
R7647 T11394 T11382 punct ;,LD
R7648 T11395 T11382 appos RBD1,LD
R7649 T11396 T11397 punct –,4
R7650 T11397 T11395 prep 4,RBD1
R7651 T11398 T11395 punct ", ",RBD1
R7652 T11399 T11400 compound Ran,binding
R7653 T11400 T11402 compound binding,domains
R7654 T11401 T11400 punct -,binding
R7655 T11402 T11395 appos domains,RBD1
R7656 T11403 T11404 quantmod 1,4
R7657 T11404 T11402 npadvmod 4,domains
R7658 T11405 T11404 punct –,4
R7659 T11406 T11382 punct ;,LD
R7660 T11407 T11382 appos ZnF,LD
R7661 T11408 T11407 punct ", ",ZnF
R7662 T11409 T11410 compound zinc,finger
R7663 T11410 T11411 compound finger,domain
R7664 T11411 T11407 appos domain,ZnF
R7665 T11412 T11411 compound cluster,domain
R7666 T11413 T11382 punct ;,LD
R7667 T11414 T11382 appos KBD,LD
R7668 T11415 T11414 punct ", ",KBD
R7669 T11416 T11417 nmod kinesin,binding
R7670 T11417 T11424 compound binding,domain
R7671 T11418 T11416 punct (,kinesin
R7672 T11419 T11420 compound KIF5B,KIF5C
R7673 T11420 T11416 appos KIF5C,kinesin
R7674 T11421 T11420 punct /,KIF5C
R7675 T11422 T11417 punct ),binding
R7676 T11423 T11417 punct -,binding
R7677 T11424 T11414 appos domain,KBD
R7678 T11425 T11382 punct ;,LD
R7679 T11426 T11382 appos CLD,LD
R7680 T11427 T11426 punct ", ",CLD
R7681 T11428 T11429 npadvmod cyclophilin,like
R7682 T11429 T11431 amod like,domain
R7683 T11430 T11429 punct -,like
R7684 T11431 T11426 appos domain,CLD
R7685 T11432 T11382 punct ;,LD
R7686 T11433 T11382 appos IR,LD
R7687 T11434 T11433 punct ", ",IR
R7688 T11435 T11436 amod internal,repeat
R7689 T11436 T11437 compound repeat,domain
R7690 T11437 T11433 appos domain,IR
R7691 T11438 T11382 punct ;,LD
R7692 T11439 T11382 appos CY,LD
R7693 T11440 T11439 punct ", ",CY
R7694 T11441 T11442 compound cyclophilin,domain
R7695 T11442 T11439 appos domain,CY
R7696 T11443 T11382 punct .,LD
R7697 T11521 T11520 prep of,Effect
R7698 T11522 T11521 pobj Cox11,of
R7699 T11523 T11522 cc and,Cox11
R7700 T11524 T11522 conj RanBP2,Cox11
R7701 T11525 T11520 prep on,Effect
R7702 T11526 T11527 compound HKI,Activity
R7703 T11527 T11525 pobj Activity,on
R7704 T11529 T11530 punct (,A
R7705 T11530 T11531 meta A,kinetics
R7706 T11532 T11530 punct ),A
R7707 T11533 T11531 compound Saturation,kinetics
R7708 T11534 T11531 punct ", ",kinetics
R7709 T11535 T11531 npadvmod rate,kinetics
R7710 T11536 T11535 cc versus,rate
R7711 T11537 T11535 conj glucose,rate
R7712 T11538 T11531 prep of,kinetics
R7713 T11539 T11538 pobj HKI,of
R7714 T11540 T11541 punct (,μg
R7715 T11541 T11539 parataxis μg,HKI
R7716 T11542 T11541 nummod 0.24,μg
R7717 T11543 T11541 punct ),μg
R7718 T11544 T11531 prep in,kinetics
R7719 T11545 T11546 det the,absence
R7720 T11546 T11544 pobj absence,in
R7721 T11547 T11548 punct (,circles
R7722 T11548 T11546 parataxis circles,absence
R7723 T11549 T11548 amod solid,circles
R7724 T11550 T11548 punct ),circles
R7725 T11551 T11546 cc and,absence
R7726 T11552 T11546 conj presence,absence
R7727 T11553 T11546 prep of,absence
R7728 T11554 T11553 pobj Cox11,of
R7729 T11555 T11556 punct (,nM
R7730 T11556 T11531 parataxis nM,kinetics
R7731 T11557 T11558 amod open,circles
R7732 T11558 T11559 dep circles,nM
R7733 T11559 T11556 dep nM,nM
R7734 T11560 T11559 punct ", ",nM
R7735 T11561 T11559 nummod 0.25,nM
R7736 T11562 T11556 punct ;,nM
R7737 T11563 T11564 amod solid,triangles
R7738 T11564 T11556 dep triangles,nM
R7739 T11565 T11556 punct ", ",nM
R7740 T11566 T11556 nummod 7.5,nM
R7741 T11567 T11556 punct ),nM
R7742 T11568 T11531 punct .,kinetics
R7743 T11570 T11571 det The,activity
R7744 T11571 T11572 nsubj activity,decreases
R7745 T11573 T11571 prep of,activity
R7746 T11574 T11573 pobj HKI,of
R7747 T11575 T11572 prep with,decreases
R7748 T11576 T11577 amod increasing,concentrations
R7749 T11577 T11575 pobj concentrations,with
R7750 T11578 T11577 prep of,concentrations
R7751 T11579 T11578 pobj Cox11,of
R7752 T11580 T11572 punct .,decreases
R7753 T11582 T11583 det No,activity
R7754 T11583 T11586 nsubjpass activity,recorded
R7755 T11584 T11583 amod measurable,activity
R7756 T11585 T11583 compound HKI,activity
R7757 T11587 T11586 auxpass was,recorded
R7758 T11588 T11586 prep in,recorded
R7759 T11589 T11590 det the,presence
R7760 T11590 T11588 pobj presence,in
R7761 T11591 T11590 prep of,presence
R7762 T11592 T11593 nummod 15,nM
R7763 T11593 T11591 pobj nM,of
R7764 T11594 T11593 prep of,nM
R7765 T11595 T11594 pobj Cox11,of
R7766 T11596 T11597 punct (,data
R7767 T11597 T11586 meta data,recorded
R7768 T11598 T11597 amod unpublished,data
R7769 T11599 T11597 punct ),data
R7770 T11600 T11586 punct .,recorded
R7771 T11602 T11603 punct (,B
R7772 T11603 T11604 meta B,plot
R7773 T11605 T11603 punct ),B
R7774 T11606 T11607 compound Hanes,Wolf
R7775 T11607 T11604 compound Wolf,plot
R7776 T11608 T11607 punct -,Wolf
R7777 T11609 T11604 prep of,plot
R7778 T11610 T11611 punct (,A
R7779 T11611 T11609 parataxis A,of
R7780 T11612 T11611 punct ),A
R7781 T11613 T11609 punct (,of
R7782 T11614 T11609 pobj 1,of
R7783 T11615 T11616 punct /,rate
R7784 T11616 T11614 prep rate,1
R7785 T11617 T11614 cc versus,1
R7786 T11618 T11614 conj glucose,1
R7787 T11619 T11604 punct ),plot
R7788 T11620 T11604 prep in,plot
R7789 T11621 T11622 det the,absence
R7790 T11622 T11620 pobj absence,in
R7791 T11623 T11622 cc and,absence
R7792 T11624 T11622 conj presence,absence
R7793 T11625 T11622 prep of,absence
R7794 T11626 T11627 amod fixed,concentrations
R7795 T11627 T11625 pobj concentrations,of
R7796 T11628 T11627 prep of,concentrations
R7797 T11629 T11628 pobj Cox11,of
R7798 T11630 T11604 punct .,plot
R7799 T11632 T11633 nsubj Linearity,supported
R7800 T11634 T11632 prep of,Linearity
R7801 T11635 T11636 amod reciprocal,plots
R7802 T11636 T11634 pobj plots,of
R7803 T11637 T11633 advmod also,supported
R7804 T11638 T11639 det the,behavior
R7805 T11639 T11633 dobj behavior,supported
R7806 T11640 T11639 amod hyperbolic,behavior
R7807 T11641 T11639 prep of,behavior
R7808 T11642 T11643 det the,reactions
R7809 T11643 T11641 pobj reactions,of
R7810 T11644 T11645 punct (,data
R7811 T11645 T11633 meta data,supported
R7812 T11646 T11645 amod unpublished,data
R7813 T11647 T11645 punct ),data
R7814 T11648 T11633 punct .,supported
R7815 T11650 T11651 nsubj Cox11,behaves
R7816 T11652 T11651 prep as,behaves
R7817 T11653 T11654 det a,inhibitor
R7818 T11654 T11652 pobj inhibitor,as
R7819 T11655 T11654 amod noncompetitive,inhibitor
R7820 T11656 T11654 prep of,inhibitor
R7821 T11657 T11656 pobj HKI,of
R7822 T11658 T11651 prep by,behaves
R7823 T11659 T11658 pcomp reducing,by
R7824 T11660 T11661 det the,V max
R7825 T11661 T11659 dobj V max,reducing
R7826 T11662 T11661 prep of,V max
R7827 T11663 T11662 pobj HKI,of
R7828 T11664 T11661 cc but,V max
R7829 T11665 T11664 neg not,but
R7830 T11666 T11667 poss its,K m
R7831 T11667 T11661 conj K m,V max
R7832 T11668 T11667 prep toward,K m
R7833 T11669 T11668 pobj glucose,toward
R7834 T11670 T11651 punct .,behaves
R7835 T11672 T11673 punct (,C
R7836 T11673 T11674 meta C,plotted
R7837 T11675 T11673 punct ),C
R7838 T11676 T11677 compound HKI,rate
R7839 T11677 T11674 nsubjpass rate,plotted
R7840 T11678 T11674 auxpass is,plotted
R7841 T11679 T11674 prep as,plotted
R7842 T11680 T11681 det a,function
R7843 T11681 T11679 pobj function,as
R7844 T11682 T11681 prep of,function
R7845 T11683 T11684 compound LD,concentration
R7846 T11684 T11682 pobj concentration,of
R7847 T11685 T11674 prep at,plotted
R7848 T11686 T11687 amod saturating,glucose
R7849 T11687 T11688 nmod glucose,concentrations
R7850 T11688 T11685 pobj concentrations,at
R7851 T11689 T11687 cc and,glucose
R7852 T11690 T11691 amod fixed,Cox11
R7853 T11691 T11687 conj Cox11,glucose
R7854 T11692 T11693 punct (,nM
R7855 T11693 T11691 parataxis nM,Cox11
R7856 T11694 T11693 nummod 7.5,nM
R7857 T11695 T11693 punct ),nM
R7858 T11696 T11674 punct .,plotted
R7859 T11699 T11700 mark that,reverse
R7860 T11700 T11698 ccomp reverse,Note
R7861 T11701 T11702 amod increasing,concentrations
R7862 T11702 T11700 nsubj concentrations,reverse
R7863 T11703 T11702 prep of,concentrations
R7864 T11704 T11705 det the,LD
R7865 T11705 T11703 pobj LD,of
R7866 T11706 T11705 prep of,LD
R7867 T11707 T11706 pobj RanBP2,of
R7868 T11708 T11709 det the,inhibition
R7869 T11709 T11700 dobj inhibition,reverse
R7870 T11710 T11709 prep of,inhibition
R7871 T11711 T11712 compound HKI,activity
R7872 T11712 T11710 pobj activity,of
R7873 T11713 T11709 prep by,inhibition
R7874 T11714 T11713 pobj Cox11,by
R7875 T11715 T11698 punct .,Note
R7876 T11717 T11718 det A,effect
R7877 T11718 T11722 nsubjpass effect,observed
R7878 T11719 T11720 advmod half,maximal
R7879 T11720 T11718 amod maximal,effect
R7880 T11721 T11720 punct -,maximal
R7881 T11723 T11718 prep of,effect
R7882 T11724 T11725 det the,LD
R7883 T11725 T11723 pobj LD,of
R7884 T11726 T11725 prep of,LD
R7885 T11727 T11726 pobj RanBP2,of
R7886 T11728 T11718 prep on,effect
R7887 T11729 T11730 compound HKI,activity
R7888 T11730 T11728 pobj activity,on
R7889 T11731 T11718 prep in,effect
R7890 T11732 T11733 det the,presence
R7891 T11733 T11731 pobj presence,in
R7892 T11734 T11733 prep of,presence
R7893 T11735 T11736 nummod 7.5,nM
R7894 T11736 T11734 pobj nM,of
R7895 T11737 T11736 prep of,nM
R7896 T11738 T11737 pobj Cox11,of
R7897 T11739 T11722 auxpass was,observed
R7898 T11740 T11722 prep at,observed
R7899 T11741 T11742 det a,concentration
R7900 T11742 T11740 pobj concentration,at
R7901 T11743 T11742 prep of,concentration
R7902 T11744 T11745 punct ~,0.05
R7903 T11745 T11746 nummod 0.05,nM
R7904 T11746 T11743 pobj nM,of
R7905 T11747 T11746 prep of,nM
R7906 T11748 T11747 pobj LD,of
R7907 T11749 T11722 punct .,observed
R7908 T11751 T11752 punct (,D
R7909 T11752 T11753 meta D,plot
R7910 T11754 T11752 punct ),D
R7911 T11755 T11753 nmod Rate,plot
R7912 T11756 T11755 cc versus,Rate
R7913 T11757 T11755 conj glucose,Rate
R7914 T11758 T11753 prep in,plot
R7915 T11759 T11760 det the,absence
R7916 T11760 T11758 pobj absence,in
R7917 T11761 T11760 cc and,absence
R7918 T11762 T11760 conj presence,absence
R7919 T11763 T11760 prep of,absence
R7920 T11764 T11765 det the,LD
R7921 T11765 T11763 pobj LD,of
R7922 T11766 T11765 prep of,LD
R7923 T11767 T11766 pobj RanBP2,of
R7924 T11768 T11753 punct .,plot
R7925 T11770 T11771 prep At,reduced
R7926 T11772 T11773 det a,concentration
R7927 T11773 T11770 pobj concentration,At
R7928 T11774 T11773 compound saturating,concentration
R7929 T11775 T11773 prep of,concentration
R7930 T11776 T11777 det the,LD
R7931 T11777 T11775 pobj LD,of
R7932 T11778 T11777 prep of,LD
R7933 T11779 T11778 pobj RanBP2,of
R7934 T11780 T11781 punct (,nM
R7935 T11781 T11773 parataxis nM,concentration
R7936 T11782 T11781 nummod 3.75,nM
R7937 T11783 T11781 punct ),nM
R7938 T11784 T11771 punct ", ",reduced
R7939 T11785 T11786 det the,activity
R7940 T11786 T11771 nsubjpass activity,reduced
R7941 T11787 T11786 compound HKI,activity
R7942 T11788 T11771 auxpass was,reduced
R7943 T11789 T11771 prep by,reduced
R7944 T11790 T11791 quantmod about,20
R7945 T11791 T11792 nummod 20,%
R7946 T11792 T11789 pobj %,by
R7947 T11793 T11771 punct .,reduced
R7948 T11796 T11795 punct ", ",v
R7949 T11797 T11795 appos rate,v
R7950 T11798 T11795 punct ;,v
R7951 T11799 T11795 appos S,v
R7952 T11800 T11799 punct ", ",S
R7953 T11801 T11799 appos glucose,S
R7954 T11802 T11795 punct .,v
R7957 T11946 T11945 prep of,Localization
R7958 T11947 T11946 pobj RanBP2,of
R7959 T11948 T11947 cc and,RanBP2
R7960 T11949 T11950 poss Its,Partners
R7961 T11950 T11947 conj Partners,RanBP2
R7962 T11951 T11950 nmod LD,Partners
R7963 T11952 T11950 amod Molecular,Partners
R7964 T11954 T11955 punct (,are
R7965 T11956 T11955 nsubj A,are
R7966 T11957 T11958 punct –,F
R7967 T11958 T11956 prep F,A
R7968 T11959 T11955 punct ),are
R7969 T11960 T11961 amod thin,cryosections
R7970 T11961 T11955 attr cryosections,are
R7971 T11962 T11961 prep of,cryosections
R7972 T11963 T11964 det an,area
R7973 T11964 T11962 pobj area,of
R7974 T11965 T11964 prep of,area
R7975 T11966 T11967 det the,hipocampus
R7976 T11967 T11965 pobj hipocampus,of
R7977 T11968 T11969 punct (,neurons
R7978 T11969 T11967 parataxis neurons,hipocampus
R7979 T11970 T11969 compound CA1,neurons
R7980 T11971 T11969 punct ),neurons
R7981 T11972 T11967 cc and,hipocampus
R7982 T11973 T11974 amod cerebral,cortex
R7983 T11974 T11967 conj cortex,hipocampus
R7984 T11975 T11967 punct ", ",hipocampus
R7985 T11976 T11967 advmod respectively,hipocampus
R7986 T11977 T11961 punct ", ",cryosections
R7987 T11978 T11961 acl immunostained,cryosections
R7988 T11979 T11978 prep against,immunostained
R7989 T11980 T11979 pobj HKI,against
R7990 T11981 T11982 punct (,A
R7991 T11982 T11980 parataxis A,HKI
R7992 T11983 T11982 cc and,A
R7993 T11984 T11982 conj D,A
R7994 T11985 T11982 punct ),A
R7995 T11986 T11980 punct ", ",HKI
R7996 T11987 T11980 conj RanBP2,HKI
R7997 T11988 T11989 punct (,B
R7998 T11989 T11987 parataxis B,RanBP2
R7999 T11990 T11989 cc and,B
R8000 T11991 T11989 conj E,B
R8001 T11992 T11989 punct ),B
R8002 T11993 T11987 punct ", ",RanBP2
R8003 T11994 T11987 cc and,RanBP2
R8004 T11995 T11996 amod merged,images
R8005 T11996 T11987 conj images,RanBP2
R8006 T11997 T11996 advmod thereof,images
R8007 T11998 T11999 punct (,C
R8008 T11999 T11996 parataxis C,images
R8009 T12000 T11999 cc and,C
R8010 T12001 T11999 conj F,C
R8011 T12002 T11999 punct ),C
R8012 T12003 T11955 punct .,are
R8013 T12006 T12007 mark that,restricted
R8014 T12007 T12005 ccomp restricted,Note
R8015 T12008 T12009 mark while,expressed
R8016 T12009 T12007 advcl expressed,restricted
R8017 T12010 T12009 nsubjpass RanBP2,expressed
R8018 T12011 T12010 cc and,RanBP2
R8019 T12012 T12010 conj HKI,RanBP2
R8020 T12013 T12009 auxpass are,expressed
R8021 T12014 T12009 advmod widely,expressed
R8022 T12015 T12009 prep among,expressed
R8023 T12016 T12009 cc and,expressed
R8024 T12017 T12009 conj colocalize,expressed
R8025 T12018 T12017 prep to,colocalize
R8026 T12019 T12020 amod hippocampal,neurons
R8027 T12020 T12017 dobj neurons,colocalize
R8028 T12021 T12022 punct (,C
R8029 T12022 T12017 parataxis C,colocalize
R8030 T12023 T12022 punct ),C
R8031 T12024 T12007 punct ", ",restricted
R8032 T12025 T12026 compound HKI,expression
R8033 T12026 T12007 nsubjpass expression,restricted
R8034 T12027 T12026 cc and,expression
R8035 T12028 T12026 conj localization,expression
R8036 T12029 T12026 prep with,expression
R8037 T12030 T12029 pobj RanBP2,with
R8038 T12031 T12007 auxpass is,restricted
R8039 T12032 T12007 prep to,restricted
R8040 T12033 T12034 det a,subset
R8041 T12034 T12032 pobj subset,to
R8042 T12035 T12034 prep of,subset
R8043 T12036 T12037 amod cortical,neurons
R8044 T12037 T12035 pobj neurons,of
R8045 T12038 T12034 punct (,subset
R8046 T12039 T12040 amod likely,interneurons
R8047 T12040 T12034 appos interneurons,subset
R8048 T12041 T12007 punct ),restricted
R8049 T12042 T12043 punct (,F
R8050 T12043 T12007 parataxis F,restricted
R8051 T12044 T12043 punct ),F
R8052 T12045 T12005 punct .,Note
R8053 T12047 T12048 nsubjpass Images,immunostained
R8054 T12049 T12047 prep of,Images
R8055 T12050 T12051 det the,region
R8056 T12051 T12049 pobj region,of
R8057 T12052 T12051 amod distal,region
R8058 T12053 T12051 prep of,region
R8059 T12054 T12055 amod bovine,cryosections
R8060 T12055 T12053 pobj cryosections,of
R8061 T12056 T12055 amod retinal,cryosections
R8062 T12057 T12055 acl comprising,cryosections
R8063 T12058 T12057 dobj part,comprising
R8064 T12059 T12058 prep of,part
R8065 T12060 T12061 det the,layer
R8066 T12061 T12059 pobj layer,of
R8067 T12062 T12061 amod nuclear,layer
R8068 T12063 T12061 prep of,layer
R8069 T12064 T12065 compound photoreceptor,neurons
R8070 T12065 T12063 pobj neurons,of
R8071 T12066 T12065 cc and,neurons
R8072 T12067 T12068 poss their,compartment
R8073 T12068 T12065 conj compartment,neurons
R8074 T12069 T12068 amod inner,compartment
R8075 T12070 T12068 punct (,compartment
R8076 T12071 T12068 amod myoid,compartment
R8077 T12072 T12071 cc and,myoid
R8078 T12073 T12071 conj ellipsoid,myoid
R8079 T12074 T12068 punct ),compartment
R8080 T12075 T12068 compound segment,compartment
R8081 T12076 T12077 punct (,G
R8082 T12077 T12057 parataxis G,comprising
R8083 T12078 T12079 punct –,O
R8084 T12079 T12077 prep O,G
R8085 T12080 T12077 punct ),G
R8086 T12081 T12048 auxpass are,immunostained
R8087 T12082 T12048 prep against,immunostained
R8088 T12083 T12082 pobj mHsp70,against
R8089 T12084 T12085 punct (,G
R8090 T12085 T12083 parataxis G,mHsp70
R8091 T12086 T12085 punct ),G
R8092 T12087 T12083 cc and,mHsp70
R8093 T12088 T12083 conj RanBP2,mHsp70
R8094 T12089 T12090 punct (,H
R8095 T12090 T12088 parataxis H,RanBP2
R8096 T12091 T12090 punct ),H
R8097 T12092 T12088 punct ", ",RanBP2
R8098 T12093 T12088 conj mHsp70,RanBP2
R8099 T12094 T12095 punct (,J
R8100 T12095 T12093 parataxis J,mHsp70
R8101 T12096 T12095 punct ),J
R8102 T12097 T12093 cc and,mHsp70
R8103 T12098 T12093 conj Cox11,mHsp70
R8104 T12099 T12100 punct (,K
R8105 T12100 T12098 parataxis K,Cox11
R8106 T12101 T12100 punct ),K
R8107 T12102 T12098 punct ", ",Cox11
R8108 T12103 T12098 conj HKI,Cox11
R8109 T12104 T12105 punct (,M
R8110 T12105 T12103 parataxis M,HKI
R8111 T12106 T12105 punct ),M
R8112 T12107 T12103 cc and,HKI
R8113 T12108 T12103 conj Cox11,HKI
R8114 T12109 T12110 punct (,N
R8115 T12110 T12108 parataxis N,Cox11
R8116 T12111 T12110 punct ),N
R8117 T12112 T12108 punct ", ",Cox11
R8118 T12113 T12108 cc and,Cox11
R8119 T12114 T12115 amod merged,images
R8120 T12115 T12108 conj images,Cox11
R8121 T12116 T12115 advmod thereof,images
R8122 T12117 T12118 punct (,I
R8123 T12118 T12048 parataxis I,immunostained
R8124 T12119 T12120 punct –,O
R8125 T12120 T12118 prep O,I
R8126 T12121 T12118 punct ),I
R8127 T12122 T12048 punct .,immunostained
R8128 T12125 T12126 det the,localization
R8129 T12126 T12124 dobj localization,Note
R8130 T12127 T12126 amod prominent,localization
R8131 T12128 T12126 prep of,localization
R8132 T12129 T12128 pobj RanBP2,of
R8133 T12130 T12129 punct ", ",RanBP2
R8134 T12131 T12129 conj mHsp70,RanBP2
R8135 T12132 T12131 punct ", ",mHsp70
R8136 T12133 T12131 cc and,mHsp70
R8137 T12134 T12131 conj Cox11,mHsp70
R8138 T12135 T12126 prep at,localization
R8139 T12136 T12137 det the,compartment
R8140 T12137 T12135 pobj compartment,at
R8141 T12138 T12139 npadvmod mitochondria,rich
R8142 T12139 T12137 amod rich,compartment
R8143 T12140 T12139 punct -,rich
R8144 T12141 T12137 amod ellipsoid,compartment
R8145 T12142 T12137 prep of,compartment
R8146 T12143 T12142 pobj photoreceptors,of
R8147 T12144 T12126 cc and,localization
R8148 T12145 T12146 det the,colocalization
R8149 T12146 T12126 conj colocalization,localization
R8150 T12147 T12146 prep of,colocalization
R8151 T12148 T12147 pobj RanBP2,of
R8152 T12149 T12148 cc and,RanBP2
R8153 T12150 T12148 conj Cox11,RanBP2
R8154 T12151 T12146 prep with,colocalization
R8155 T12152 T12151 pobj mHsp70,with
R8156 T12153 T12154 punct (,I
R8157 T12154 T12146 parataxis I,colocalization
R8158 T12155 T12154 cc and,I
R8159 T12156 T12154 conj L,I
R8160 T12157 T12154 punct ),I
R8161 T12158 T12124 punct ", ",Note
R8162 T12159 T12160 mark while,limited
R8163 T12160 T12124 advcl limited,Note
R8164 T12161 T12162 compound HKI,colocalization
R8165 T12162 T12160 nsubjpass colocalization,limited
R8166 T12163 T12162 prep with,colocalization
R8167 T12164 T12163 pobj Cox11,with
R8168 T12165 T12160 auxpass was,limited
R8169 T12166 T12160 prep to,limited
R8170 T12167 T12168 amod restricted,foci
R8171 T12168 T12166 pobj foci,to
R8172 T12169 T12170 punct (,arrowheads
R8173 T12170 T12160 parataxis arrowheads,limited
R8174 T12171 T12170 dep R,arrowheads
R8175 T12172 T12170 punct ", ",arrowheads
R8176 T12173 T12170 punct ),arrowheads
R8177 T12174 T12124 punct .,Note
R8178 T12176 T12177 amod High,resolution
R8179 T12177 T12179 compound resolution,images
R8180 T12178 T12177 punct -,resolution
R8181 T12179 T12180 nsubj images,confirmed
R8182 T12181 T12179 prep of,images
R8183 T12182 T12183 amod dissociated,neurons
R8184 T12183 T12181 pobj neurons,of
R8185 T12184 T12183 amod primary,neurons
R8186 T12185 T12183 amod cerebral,neurons
R8187 T12186 T12183 cc and,neurons
R8188 T12187 T12188 amod glial,cells
R8189 T12188 T12183 conj cells,neurons
R8190 T12189 T12190 mark that,was
R8191 T12190 T12180 ccomp was,confirmed
R8192 T12191 T12192 det the,colocalization
R8193 T12192 T12190 nsubj colocalization,was
R8194 T12193 T12192 prep of,colocalization
R8195 T12194 T12193 pobj HKI,of
R8196 T12195 T12194 cc and,HKI
R8197 T12196 T12194 conj Cox11,HKI
R8198 T12197 T12198 advmod highly,restricted
R8199 T12198 T12190 acomp restricted,was
R8200 T12199 T12200 punct (,P
R8201 T12200 T12198 parataxis P,restricted
R8202 T12201 T12202 punct –,R
R8203 T12202 T12200 prep R,P
R8204 T12203 T12200 punct ),P
R8205 T12204 T12190 punct ", ",was
R8206 T12205 T12206 mark while,colocalized
R8207 T12206 T12190 advcl colocalized,was
R8208 T12207 T12206 nsubj RanBP2,colocalized
R8209 T12208 T12206 advmod extensively,colocalized
R8210 T12209 T12206 prep with,colocalized
R8211 T12210 T12209 pobj HKI,with
R8212 T12211 T12212 punct (,S
R8213 T12212 T12210 parataxis S,HKI
R8214 T12213 T12214 punct –,U
R8215 T12214 T12212 prep U,S
R8216 T12215 T12212 punct ),S
R8217 T12216 T12210 cc and,HKI
R8218 T12217 T12210 conj mHsp70,HKI
R8219 T12218 T12219 punct (,V
R8220 T12219 T12217 parataxis V,mHsp70
R8221 T12220 T12221 punct –,Z
R8222 T12221 T12219 prep Z,V
R8223 T12222 T12219 punct ),V
R8224 T12223 T12180 punct .,confirmed
R8225 T12225 T12226 compound Scale,bars
R8226 T12226 T12227 nsubj bars,are
R8227 T12228 T12226 prep in,bars
R8228 T12229 T12228 pobj A,in
R8229 T12230 T12231 punct –,O
R8230 T12231 T12229 prep O,A
R8231 T12232 T12229 cc and,A
R8232 T12233 T12229 conj P,A
R8233 T12234 T12235 punct –,Z
R8234 T12235 T12233 prep Z,P
R8235 T12236 T12237 nummod 40,μm
R8236 T12237 T12227 attr μm,are
R8237 T12238 T12236 cc and,40
R8238 T12239 T12236 conj 10,40
R8239 T12240 T12227 punct ", ",are
R8240 T12241 T12227 advmod respectively,are
R8241 T12242 T12227 punct .,are
R8242 T12245 T12244 punct ", ",ONL
R8243 T12246 T12247 amod outer,layer
R8244 T12247 T12244 appos layer,ONL
R8245 T12248 T12247 amod nuclear,layer
R8246 T12249 T12244 punct .,ONL
R8251 T12535 T12536 compound Insertion,Mutagenesis
R8252 T12537 T12536 prep of,Mutagenesis
R8253 T12538 T12539 det the,Gene
R8254 T12539 T12537 pobj Gene,of
R8255 T12540 T12539 amod Murine,Gene
R8256 T12541 T12539 compound RanBP2,Gene
R8257 T12543 T12544 punct (,A
R8258 T12544 T12545 meta A,Diagram
R8259 T12546 T12544 punct ),A
R8260 T12547 T12545 prep of,Diagram
R8261 T12548 T12549 det the,region
R8262 T12549 T12547 pobj region,of
R8263 T12550 T12549 amod genomic,region
R8264 T12551 T12549 prep of,region
R8265 T12552 T12551 pobj RanBP2,of
R8266 T12553 T12549 acl disrupted,region
R8267 T12554 T12553 agent by,disrupted
R8268 T12555 T12556 compound insertion,trap
R8269 T12556 T12557 compound trap,mutagenesis
R8270 T12557 T12554 pobj mutagenesis,by
R8271 T12558 T12557 prep with,mutagenesis
R8272 T12559 T12560 det a,vector
R8273 T12560 T12558 pobj vector,with
R8274 T12561 T12560 amod bicistronic,vector
R8275 T12562 T12560 compound reporter,vector
R8276 T12563 T12560 prep between,vector
R8277 T12564 T12565 nmod exon,1
R8278 T12565 T12563 pobj 1,between
R8279 T12566 T12565 cc and,1
R8280 T12567 T12565 conj 2,1
R8281 T12568 T12545 punct .,Diagram
R8282 T12570 T12571 det The,transcript
R8283 T12571 T12573 nsubj transcript,produces
R8284 T12572 T12571 amod bicistronic,transcript
R8285 T12574 T12575 nummod two,proteins
R8286 T12575 T12573 dobj proteins,produces
R8287 T12576 T12573 prep under,produces
R8288 T12577 T12576 pobj regulation,under
R8289 T12578 T12577 prep of,regulation
R8290 T12579 T12578 pobj RanBP2,of
R8291 T12580 T12573 punct .,produces
R8292 T12582 T12583 prep Upon,generated
R8293 T12584 T12582 pobj splicing,Upon
R8294 T12585 T12584 prep of,splicing
R8295 T12586 T12585 pobj RanBP2,of
R8296 T12587 T12583 punct ", ",generated
R8297 T12588 T12589 det a,fusion
R8298 T12589 T12583 nsubjpass fusion,generated
R8299 T12590 T12589 prep between,fusion
R8300 T12591 T12590 pobj exon,between
R8301 T12592 T12591 nummod 1,exon
R8302 T12593 T12591 cc and,exon
R8303 T12594 T12595 compound β,geo
R8304 T12595 T12591 conj geo,exon
R8305 T12596 T12595 punct -,geo
R8306 T12597 T12595 punct (,geo
R8307 T12598 T12599 det a,fusion
R8308 T12599 T12595 appos fusion,geo
R8309 T12600 T12599 prep between,fusion
R8310 T12601 T12602 det the,genes
R8311 T12602 T12600 pobj genes,between
R8312 T12603 T12604 nmod β,gal
R8313 T12604 T12602 nmod gal,genes
R8314 T12605 T12604 punct -,gal
R8315 T12606 T12604 cc and,gal
R8316 T12607 T12604 conj neo,gal
R8317 T12608 T12583 punct ),generated
R8318 T12609 T12583 auxpass is,generated
R8319 T12610 T12583 punct ", ",generated
R8320 T12611 T12612 mark while,translated
R8321 T12612 T12583 advcl translated,generated
R8322 T12613 T12614 amod human,phophatase
R8323 T12614 T12612 nsubjpass phophatase,translated
R8324 T12615 T12614 amod placental,phophatase
R8325 T12616 T12614 compound alkaline,phophatase
R8326 T12617 T12614 punct (,phophatase
R8327 T12618 T12614 appos PLAP,phophatase
R8328 T12619 T12612 punct ),translated
R8329 T12620 T12612 auxpass is,translated
R8330 T12621 T12612 advmod independently,translated
R8331 T12622 T12612 advcl using,translated
R8332 T12623 T12624 det the,site
R8333 T12624 T12622 dobj site,using
R8334 T12625 T12626 amod internal,entry
R8335 T12626 T12624 compound entry,site
R8336 T12627 T12626 compound ribosome,entry
R8337 T12628 T12583 punct .,generated
R8338 T12630 T12631 advcl Consistent,directed
R8339 T12632 T12630 prep with,Consistent
R8340 T12633 T12634 amod previous,studies
R8341 T12634 T12632 pobj studies,with
R8342 T12635 T12631 punct ", ",directed
R8343 T12636 T12637 det the,expression
R8344 T12637 T12631 nsubjpass expression,directed
R8345 T12638 T12637 prep of,expression
R8346 T12639 T12640 det the,former
R8347 T12640 T12638 pobj former,of
R8348 T12641 T12631 auxpass is,directed
R8349 T12642 T12631 prep to,directed
R8350 T12643 T12644 compound cell,bodies
R8351 T12644 T12642 pobj bodies,to
R8352 T12645 T12631 punct ", ",directed
R8353 T12646 T12647 mark while,targeted
R8354 T12647 T12631 advcl targeted,directed
R8355 T12648 T12647 nsubjpass expression,targeted
R8356 T12649 T12648 prep of,expression
R8357 T12650 T12651 det the,latter
R8358 T12651 T12649 pobj latter,of
R8359 T12652 T12647 auxpass is,targeted
R8360 T12653 T12647 prep to,targeted
R8361 T12654 T12655 det the,processes
R8362 T12655 T12653 pobj processes,to
R8363 T12656 T12655 amod axonal,processes
R8364 T12657 T12658 punct [,68
R8365 T12658 T12647 parataxis 68,targeted
R8366 T12659 T12658 nummod 67,68
R8367 T12660 T12658 punct ",",68
R8368 T12661 T12658 punct ],68
R8369 T12662 T12631 punct .,directed
R8370 T12664 T12665 amod Transcriptional,analysis
R8371 T12665 T12669 nsubj analysis,detects
R8372 T12666 T12665 nummod 5,analysis
R8373 T12667 T12666 punct ′,5
R8374 T12668 T12665 compound RACE,analysis
R8375 T12670 T12671 det a,fusion
R8376 T12671 T12669 dobj fusion,detects
R8377 T12672 T12671 prep between,fusion
R8378 T12673 T12672 pobj exon,between
R8379 T12674 T12673 nummod 1,exon
R8380 T12675 T12673 cc and,exon
R8381 T12676 T12677 compound β,geo
R8382 T12677 T12673 conj geo,exon
R8383 T12678 T12677 punct -,geo
R8384 T12679 T12669 punct .,detects
R8385 T12681 T12682 punct (,B
R8386 T12682 T12683 meta B,analysis
R8387 T12684 T12682 punct ),B
R8388 T12685 T12683 compound Southern,analysis
R8389 T12686 T12683 prep of,analysis
R8390 T12687 T12688 det the,locus
R8391 T12688 T12686 pobj locus,of
R8392 T12689 T12688 compound RanBP2,locus
R8393 T12690 T12688 prep of,locus
R8394 T12691 T12692 amod wild,type
R8395 T12692 T12694 nmod type,DNA
R8396 T12693 T12692 punct -,type
R8397 T12694 T12690 pobj DNA,of
R8398 T12695 T12692 cc and,type
R8399 T12696 T12692 conj heterozygous,type
R8400 T12697 T12694 amod genomic,DNA
R8401 T12698 T12694 prep of,DNA
R8402 T12699 T12698 pobj tails,of
R8403 T12700 T12699 prep of,tails
R8404 T12701 T12702 compound F1,mice
R8405 T12702 T12700 pobj mice,of
R8406 T12703 T12702 acl digested,mice
R8407 T12704 T12703 prep with,digested
R8408 T12705 T12704 pobj PpuMI,with
R8409 T12706 T12707 punct (,panel
R8410 T12707 T12705 parataxis panel,PpuMI
R8411 T12708 T12707 amod left,panel
R8412 T12709 T12707 punct ),panel
R8413 T12710 T12705 cc and,PpuMI
R8414 T12711 T12705 conj HindIII,PpuMI
R8415 T12712 T12713 punct (,panel
R8416 T12713 T12711 parataxis panel,HindIII
R8417 T12714 T12713 amod right,panel
R8418 T12715 T12713 punct ),panel
R8419 T12716 T12703 prep with,digested
R8420 T12717 T12716 pobj probes,with
R8421 T12718 T12717 prep at,probes
R8422 T12719 T12720 det the,regions
R8423 T12720 T12718 pobj regions,at
R8424 T12721 T12720 nummod 3,regions
R8425 T12722 T12721 punct ′,3
R8426 T12723 T12724 punct (,panel
R8427 T12724 T12721 parataxis panel,3
R8428 T12725 T12724 amod left,panel
R8429 T12726 T12724 punct ),panel
R8430 T12727 T12721 cc and,3
R8431 T12728 T12721 conj 5,3
R8432 T12729 T12728 punct ′,5
R8433 T12730 T12731 punct (,panel
R8434 T12731 T12728 parataxis panel,5
R8435 T12732 T12731 amod right,panel
R8436 T12733 T12731 punct ),panel
R8437 T12734 T12720 compound flanking,regions
R8438 T12735 T12720 prep of,regions
R8439 T12736 T12737 det the,breakpoint
R8440 T12737 T12735 pobj breakpoint,of
R8441 T12738 T12737 compound insertion,breakpoint
R8442 T12739 T12683 punct .,analysis
R8443 T12741 T12742 nsubj Q1,is
R8444 T12743 T12744 det a,cosmid
R8445 T12744 T12742 attr cosmid,is
R8446 T12745 T12744 acl containing,cosmid
R8447 T12746 T12747 det the,gene
R8448 T12747 T12745 dobj gene,containing
R8449 T12748 T12747 compound RanBP2,gene
R8450 T12749 T12745 prep up,containing
R8451 T12750 T12749 prep to,up
R8452 T12751 T12750 pobj exon,to
R8453 T12752 T12751 nummod 20,exon
R8454 T12753 T12754 punct [,4
R8455 T12754 T12745 parataxis 4,containing
R8456 T12755 T12754 punct ],4
R8457 T12756 T12742 punct .,is
R8458 T12758 T12759 punct (,C
R8459 T12759 T12760 meta C,view
R8460 T12761 T12759 punct ),C
R8461 T12762 T12760 amod Lateroventral,view
R8462 T12763 T12760 prep of,view
R8463 T12764 T12765 det a,stain
R8464 T12765 T12763 pobj stain,of
R8465 T12766 T12767 amod whole,mount
R8466 T12767 T12765 compound mount,stain
R8467 T12768 T12767 punct -,mount
R8468 T12769 T12765 prep of,stain
R8469 T12770 T12771 det a,embryo
R8470 T12771 T12769 pobj embryo,of
R8471 T12772 T12773 punct ~,12.5
R8472 T12773 T12774 nummod 12.5,dpc
R8473 T12774 T12771 nmod dpc,embryo
R8474 T12775 T12771 amod heterozygous,embryo
R8475 T12776 T12765 prep for,stain
R8476 T12777 T12778 nmod PLAP,activities
R8477 T12778 T12776 pobj activities,for
R8478 T12779 T12777 cc and,PLAP
R8479 T12780 T12781 compound β,gal
R8480 T12781 T12777 conj gal,PLAP
R8481 T12782 T12781 punct -,gal
R8482 T12783 T12784 punct (,picture
R8483 T12784 T12781 parataxis picture,gal
R8484 T12785 T12784 compound inset,picture
R8485 T12786 T12784 punct ),picture
R8486 T12787 T12760 punct .,view
R8487 T12789 T12790 mark Although,expressed
R8488 T12790 T12794 advcl expressed,was
R8489 T12791 T12790 nsubjpass PLAP,expressed
R8490 T12792 T12790 auxpass was,expressed
R8491 T12793 T12790 advmod broadly,expressed
R8492 T12795 T12790 punct (,expressed
R8493 T12796 T12797 advmod e.g.,somites
R8494 T12797 T12790 npadvmod somites,expressed
R8495 T12798 T12797 punct ", ",somites
R8496 T12799 T12797 punct ", ",somites
R8497 T12800 T12797 conj limbs,somites
R8498 T12801 T12800 punct ", ",limbs
R8499 T12802 T12800 cc and,limbs
R8500 T12803 T12800 conj CNS,limbs
R8501 T12804 T12794 punct ),was
R8502 T12805 T12794 punct ", ",was
R8503 T12806 T12807 det the,expression
R8504 T12807 T12794 nsubj expression,was
R8505 T12808 T12807 nmod PLAP,expression
R8506 T12809 T12808 cc and,PLAP
R8507 T12810 T12811 compound β,Gal
R8508 T12811 T12808 conj Gal,PLAP
R8509 T12812 T12811 punct -,Gal
R8510 T12813 T12814 punct (,picture
R8511 T12814 T12811 parataxis picture,Gal
R8512 T12815 T12814 compound inset,picture
R8513 T12816 T12814 punct ),picture
R8514 T12817 T12818 advmod particularly,high
R8515 T12818 T12794 acomp high,was
R8516 T12819 T12794 prep in,was
R8517 T12820 T12821 det the,vesicle
R8518 T12821 T12819 pobj vesicle,in
R8519 T12822 T12821 amod optic,vesicle
R8520 T12823 T12824 punct (,arrow
R8521 T12824 T12794 parataxis arrow,was
R8522 T12825 T12824 punct ),arrow
R8523 T12826 T12794 punct .,was
R8524 T12828 T12829 nmod X,gal
R8525 T12829 T12831 nmod gal,staining
R8526 T12830 T12829 punct -,gal
R8527 T12832 T12831 amod single,staining
R8528 T12833 T12834 punct (,D
R8529 T12834 T12832 parataxis D,single
R8530 T12835 T12834 punct ),D
R8531 T12836 T12832 cc and,single
R8532 T12837 T12832 conj combined,single
R8533 T12838 T12831 prep with,staining
R8534 T12839 T12838 pobj PLAP,with
R8535 T12840 T12841 punct (,E
R8536 T12841 T12839 parataxis E,PLAP
R8537 T12842 T12841 punct ),E
R8538 T12843 T12831 prep of,staining
R8539 T12844 T12845 det a,section
R8540 T12845 T12843 pobj section,of
R8541 T12846 T12845 amod retinal,section
R8542 T12847 T12845 prep of,section
R8543 T12848 T12849 det a,mouse
R8544 T12849 T12847 pobj mouse,of
R8545 T12850 T12851 nummod 3,mo
R8546 T12851 T12853 npadvmod mo,old
R8547 T12852 T12851 punct -,mo
R8548 T12853 T12849 amod old,mouse
R8549 T12854 T12853 punct -,old
R8550 T12855 T12849 nmod RanBP2,mouse
R8551 T12856 T12855 punct +,RanBP2
R8552 T12857 T12855 punct /,RanBP2
R8553 T12858 T12855 punct −,RanBP2
R8554 T12859 T12831 punct .,staining
R8555 T12861 T12862 advcl Consistent,detected
R8556 T12863 T12861 prep with,Consistent
R8557 T12864 T12865 amod previous,studies
R8558 T12865 T12863 pobj studies,with
R8559 T12866 T12865 compound immunocytochemistry,studies
R8560 T12867 T12862 punct ", ",detected
R8561 T12868 T12869 compound β,Gal
R8562 T12869 T12871 compound Gal,activity
R8563 T12870 T12869 punct -,Gal
R8564 T12871 T12862 nsubjpass activity,detected
R8565 T12872 T12862 auxpass is,detected
R8566 T12873 T12862 prep in,detected
R8567 T12874 T12875 det the,bodies
R8568 T12875 T12873 pobj bodies,in
R8569 T12876 T12875 amod neuroretinal,bodies
R8570 T12877 T12875 cc and,bodies
R8571 T12878 T12879 amod inner,compartment
R8572 T12879 T12875 conj compartment,bodies
R8573 T12880 T12879 compound segment,compartment
R8574 T12881 T12875 prep of,bodies
R8575 T12882 T12881 pobj photoreceptors,of
R8576 T12883 T12882 prep with,photoreceptors
R8577 T12884 T12885 advmod conspicuously,strong
R8578 T12885 T12886 amod strong,expression
R8579 T12886 T12883 pobj expression,with
R8580 T12887 T12886 prep in,expression
R8581 T12888 T12889 compound ganglion,cells
R8582 T12889 T12887 pobj cells,in
R8583 T12890 T12862 punct .,detected
R8584 T12892 T12893 compound PLAP,expression
R8585 T12893 T12894 nsubjpass expression,found
R8586 T12895 T12894 auxpass is,found
R8587 T12896 T12894 prep throughout,found
R8588 T12897 T12898 det the,layers
R8589 T12898 T12896 pobj layers,throughout
R8590 T12899 T12900 amod plexiform,synaptic
R8591 T12900 T12898 amod synaptic,layers
R8592 T12901 T12900 punct /,synaptic
R8593 T12902 T12898 cc and,layers
R8594 T12903 T12904 amod outer,segment
R8595 T12904 T12898 conj segment,layers
R8596 T12905 T12904 prep of,segment
R8597 T12906 T12905 pobj photoreceptors,of
R8598 T12907 T12908 punct (,E
R8599 T12908 T12894 parataxis E,found
R8600 T12909 T12908 punct ),E
R8601 T12910 T12894 punct .,found
R8602 T12913 T12912 punct ", ",GC
R8603 T12914 T12915 compound ganglion,cell
R8604 T12915 T12912 appos cell,GC
R8605 T12916 T12912 punct ;,GC
R8606 T12917 T12912 appos PLAP,GC
R8607 T12918 T12917 punct ", ",PLAP
R8608 T12919 T12920 amod human,phophatase
R8609 T12920 T12917 appos phophatase,PLAP
R8610 T12921 T12920 amod placental,phophatase
R8611 T12922 T12920 compound alkaline,phophatase
R8612 T12923 T12912 punct ;,GC
R8613 T12924 T12912 appos ROS,GC
R8614 T12925 T12924 punct ", ",ROS
R8615 T12926 T12927 nmod rod,segment
R8616 T12927 T12924 appos segment,ROS
R8617 T12928 T12927 amod outer,segment
R8618 T12929 T12912 punct ;,GC
R8619 T12930 T12912 appos RIS,GC
R8620 T12931 T12930 punct ", ",RIS
R8621 T12932 T12933 nmod rod,segment
R8622 T12933 T12930 appos segment,RIS
R8623 T12934 T12933 amod inner,segment
R8624 T12935 T12912 punct ;,GC
R8625 T12936 T12912 appos ONL,GC
R8626 T12937 T12936 punct ", ",ONL
R8627 T12938 T12939 amod outer,layer
R8628 T12939 T12936 appos layer,ONL
R8629 T12940 T12939 amod nuclear,layer
R8630 T12941 T12912 punct ;,GC
R8631 T12942 T12912 appos OPL,GC
R8632 T12943 T12942 punct ", ",OPL
R8633 T12944 T12945 amod outer,layer
R8634 T12945 T12942 appos layer,OPL
R8635 T12946 T12945 amod plexiform,layer
R8636 T12947 T12945 punct (,layer
R8637 T12948 T12945 amod synaptic,layer
R8638 T12949 T12945 punct ),layer
R8639 T12950 T12912 punct ;,GC
R8640 T12951 T12912 appos INL,GC
R8641 T12952 T12951 punct ", ",INL
R8642 T12953 T12954 amod inner,layer
R8643 T12954 T12951 appos layer,INL
R8644 T12955 T12954 amod nuclear,layer
R8645 T12956 T12912 punct ;,GC
R8646 T12957 T12912 appos IPL,GC
R8647 T12958 T12957 punct ", ",IPL
R8648 T12959 T12960 amod inner,layer
R8649 T12960 T12957 appos layer,IPL
R8650 T12961 T12960 amod plexiform,layer
R8651 T12962 T12960 punct (,layer
R8652 T12963 T12960 amod synaptic,layer
R8653 T12964 T12960 punct ),layer
R8654 T12965 T12912 punct ;,GC
R8655 T12966 T12912 appos GC,GC
R8656 T12967 T12966 punct ", ",GC
R8657 T12968 T12969 compound ganglion,cell
R8658 T12969 T12970 compound cell,layer
R8659 T12970 T12966 appos layer,GC
R8660 T12971 T12912 punct .,GC
R8661 T13139 T13140 nsubj Haploinsufficiency,Causes
R8662 T13141 T13139 prep of,Haploinsufficiency
R8663 T13142 T13141 pobj RanBP2,of
R8664 T13143 T13144 det a,Decrease
R8665 T13144 T13140 dobj Decrease,Causes
R8666 T13145 T13144 prep in,Decrease
R8667 T13146 T13147 compound HKI,Protein
R8668 T13147 T13145 pobj Protein,in
R8669 T13148 T13147 cc and,Protein
R8670 T13149 T13150 compound ATP,Levels
R8671 T13150 T13147 conj Levels,Protein
R8672 T13152 T13153 punct (,A
R8673 T13153 T13154 meta A,analysis
R8674 T13155 T13153 punct ),A
R8675 T13156 T13154 amod Quantitative,analysis
R8676 T13157 T13154 prep of,analysis
R8677 T13158 T13157 pobj NPCs,of
R8678 T13159 T13154 prep in,analysis
R8679 T13160 T13161 amod dissociated,neurons
R8680 T13161 T13159 pobj neurons,in
R8681 T13162 T13161 amod hippocampal,neurons
R8682 T13163 T13161 prep of,neurons
R8683 T13164 T13165 amod wild,type
R8684 T13165 T13167 nmod type,mice
R8685 T13166 T13165 punct -,type
R8686 T13167 T13163 pobj mice,of
R8687 T13168 T13169 punct (,+
R8688 T13169 T13165 punct +,type
R8689 T13170 T13169 punct +,+
R8690 T13171 T13169 punct /,+
R8691 T13172 T13169 punct ),+
R8692 T13173 T13165 cc and,type
R8693 T13174 T13165 conj heterozygote,type
R8694 T13175 T13176 punct (,−
R8695 T13176 T13174 punct −,heterozygote
R8696 T13177 T13176 punct +,−
R8697 T13178 T13176 punct /,−
R8698 T13179 T13176 punct ),−
R8699 T13180 T13154 prep upon,analysis
R8700 T13181 T13180 pobj immunostaining,upon
R8701 T13182 T13181 prep with,immunostaining
R8702 T13183 T13182 pobj mAb414,with
R8703 T13184 T13154 punct .,analysis
R8704 T13186 T13187 det No,difference
R8705 T13187 T13188 nsubjpass difference,found
R8706 T13189 T13187 prep in,difference
R8707 T13190 T13191 det the,density
R8708 T13191 T13189 pobj density,in
R8709 T13192 T13191 prep of,density
R8710 T13193 T13192 pobj NPCs,of
R8711 T13194 T13191 punct (,density
R8712 T13195 T13196 quantmod 3,4
R8713 T13196 T13198 nummod 4,NPC
R8714 T13197 T13196 punct –,4
R8715 T13198 T13191 appos NPC,density
R8716 T13199 T13200 punct /,μm2
R8717 T13200 T13198 prep μm2,NPC
R8718 T13201 T13191 punct ),density
R8719 T13202 T13191 prep at,density
R8720 T13203 T13204 det the,envelope
R8721 T13204 T13202 pobj envelope,at
R8722 T13205 T13204 amod nuclear,envelope
R8723 T13206 T13188 auxpass was,found
R8724 T13207 T13188 prep between,found
R8725 T13208 T13209 nmod RanBP2,mice
R8726 T13209 T13207 pobj mice,between
R8727 T13210 T13208 punct +,RanBP2
R8728 T13211 T13208 punct /,RanBP2
R8729 T13212 T13208 punct +,RanBP2
R8730 T13213 T13208 cc and,RanBP2
R8731 T13214 T13208 conj RanBP2,RanBP2
R8732 T13215 T13214 punct +,RanBP2
R8733 T13216 T13214 punct /,RanBP2
R8734 T13217 T13214 punct −,RanBP2
R8735 T13218 T13188 punct .,found
R8736 T13220 T13221 punct (,B
R8737 T13221 T13222 meta B,Immunoblots
R8738 T13223 T13221 punct ),B
R8739 T13224 T13222 prep with,Immunoblots
R8740 T13225 T13226 nmod anti-RanBP2,Nup62
R8741 T13226 T13230 nmod Nup62,antibodies
R8742 T13227 T13226 punct /,Nup62
R8743 T13228 T13226 nmod Nup153,Nup62
R8744 T13229 T13226 punct /,Nup62
R8745 T13230 T13224 pobj antibodies,with
R8746 T13231 T13226 punct (,Nup62
R8747 T13232 T13226 appos mAb414,Nup62
R8748 T13233 T13226 punct ),Nup62
R8749 T13234 T13226 punct ", ",Nup62
R8750 T13235 T13236 punct −,HKI
R8751 T13236 T13226 conj HKI,Nup62
R8752 T13237 T13236 punct ", ",HKI
R8753 T13238 T13239 punct −,mHsp70
R8754 T13239 T13236 conj mHsp70,HKI
R8755 T13240 T13239 punct ", ",mHsp70
R8756 T13241 T13239 cc and,mHsp70
R8757 T13242 T13243 punct −,Cox11
R8758 T13243 T13239 conj Cox11,mHsp70
R8759 T13244 T13230 prep of,antibodies
R8760 T13245 T13246 amod retinal,homogenates
R8761 T13246 T13244 pobj homogenates,of
R8762 T13247 T13248 punct (,panel
R8763 T13248 T13245 parataxis panel,retinal
R8764 T13249 T13248 amod top,panel
R8765 T13250 T13248 punct ),panel
R8766 T13251 T13245 cc and,retinal
R8767 T13252 T13245 conj hippocampal,retinal
R8768 T13253 T13246 prep of,homogenates
R8769 T13254 T13255 punct +,+
R8770 T13255 T13257 punct +,mice
R8771 T13256 T13255 punct /,+
R8772 T13257 T13253 pobj mice,of
R8773 T13258 T13255 cc and,+
R8774 T13259 T13260 punct +,−
R8775 T13260 T13255 conj −,+
R8776 T13261 T13260 punct /,−
R8777 T13262 T13222 punct .,Immunoblots
R8778 T13264 T13265 prep In,exhibit
R8779 T13266 T13264 pobj comparison,In
R8780 T13267 T13266 prep to,comparison
R8781 T13268 T13267 pobj RanBP2,to
R8782 T13269 T13268 punct +,RanBP2
R8783 T13270 T13268 punct /,RanBP2
R8784 T13271 T13268 punct +,RanBP2
R8785 T13272 T13265 punct ", ",exhibit
R8786 T13273 T13274 nmod RanBP2,mice
R8787 T13274 T13265 nsubj mice,exhibit
R8788 T13275 T13273 punct +,RanBP2
R8789 T13276 T13273 punct /,RanBP2
R8790 T13277 T13273 punct −,RanBP2
R8791 T13278 T13279 det a,reduction
R8792 T13279 T13265 dobj reduction,exhibit
R8793 T13280 T13279 prep in,reduction
R8794 T13281 T13282 det the,levels
R8795 T13282 T13280 pobj levels,in
R8796 T13283 T13282 compound expression,levels
R8797 T13284 T13282 prep of,levels
R8798 T13285 T13284 pobj RanBP2,of
R8799 T13286 T13285 cc and,RanBP2
R8800 T13287 T13285 conj HKI,RanBP2
R8801 T13288 T13284 cc but,of
R8802 T13289 T13288 neg not,but
R8803 T13290 T13284 conj of,of
R8804 T13291 T13292 amod other,proteins
R8805 T13292 T13290 pobj proteins,of
R8806 T13293 T13265 punct .,exhibit
R8807 T13295 T13296 punct (,C
R8808 T13296 T13297 meta C,analysis
R8809 T13298 T13296 punct ),C
R8810 T13299 T13297 amod Quantitative,analysis
R8811 T13300 T13297 prep of,analysis
R8812 T13301 T13302 amod relative,levels
R8813 T13302 T13300 pobj levels,of
R8814 T13303 T13304 compound protein,expression
R8815 T13304 T13302 compound expression,levels
R8816 T13305 T13302 prep of,levels
R8817 T13306 T13305 pobj RanBP2,of
R8818 T13307 T13306 punct ", ",RanBP2
R8819 T13308 T13306 conj Cox11,RanBP2
R8820 T13309 T13308 punct ", ",Cox11
R8821 T13310 T13308 conj HKI,Cox11
R8822 T13311 T13310 punct ", ",HKI
R8823 T13312 T13310 cc and,HKI
R8824 T13313 T13310 conj mHsp70,HKI
R8825 T13314 T13297 prep in,analysis
R8826 T13315 T13316 det the,hippocampus
R8827 T13316 T13314 pobj hippocampus,in
R8828 T13317 T13316 prep of,hippocampus
R8829 T13318 T13319 nmod RanBP2,mice
R8830 T13319 T13317 pobj mice,of
R8831 T13320 T13318 punct +,RanBP2
R8832 T13321 T13318 punct /,RanBP2
R8833 T13322 T13318 punct +,RanBP2
R8834 T13323 T13318 cc and,RanBP2
R8835 T13324 T13318 conj RanBP2,RanBP2
R8836 T13325 T13324 punct +,RanBP2
R8837 T13326 T13324 punct /,RanBP2
R8838 T13327 T13324 punct −,RanBP2
R8839 T13328 T13297 punct .,analysis
R8840 T13330 T13331 expl There,is
R8841 T13332 T13333 punct ~,2
R8842 T13333 T13334 nummod 2,reduction
R8843 T13334 T13331 attr reduction,is
R8844 T13335 T13333 punct -,2
R8845 T13336 T13333 cc and,2
R8846 T13337 T13333 conj 4-fold,2
R8847 T13338 T13334 prep of,reduction
R8848 T13339 T13338 pobj RanBP2,of
R8849 T13340 T13339 cc and,RanBP2
R8850 T13341 T13339 conj HKI,RanBP2
R8851 T13342 T13331 prep in,is
R8852 T13343 T13344 compound heterozygote,mice
R8853 T13344 T13342 pobj mice,in
R8854 T13345 T13331 punct .,is
R8855 T13347 T13348 punct (,D
R8856 T13348 T13349 meta D,reduced
R8857 T13350 T13348 punct ),D
R8858 T13351 T13352 det The,level
R8859 T13352 T13349 nsubjpass level,reduced
R8860 T13353 T13352 prep of,level
R8861 T13354 T13353 pobj HKI,of
R8862 T13355 T13349 auxpass is,reduced
R8863 T13356 T13349 prep in,reduced
R8864 T13357 T13358 det the,brain
R8865 T13358 T13356 pobj brain,in
R8866 T13359 T13356 cc but,in
R8867 T13360 T13359 neg not,but
R8868 T13361 T13356 conj in,in
R8869 T13362 T13363 amod other,tissues
R8870 T13363 T13361 pobj tissues,in
R8871 T13364 T13363 amod non-neuronal,tissues
R8872 T13365 T13363 acl tested,tissues
R8873 T13366 T13363 punct (,tissues
R8874 T13367 T13363 appos muscle,tissues
R8875 T13368 T13367 punct ", ",muscle
R8876 T13369 T13367 conj spleen,muscle
R8877 T13370 T13369 punct ", ",spleen
R8878 T13371 T13369 cc and,spleen
R8879 T13372 T13369 conj liver,spleen
R8880 T13373 T13349 punct ),reduced
R8881 T13374 T13349 punct .,reduced
R8882 T13376 T13377 punct (,E
R8883 T13377 T13378 meta E,reduced
R8884 T13379 T13377 punct ),E
R8885 T13380 T13381 det The,level
R8886 T13381 T13378 nsubjpass level,reduced
R8887 T13382 T13381 amod total,level
R8888 T13383 T13381 compound ATP,level
R8889 T13384 T13378 auxpass is,reduced
R8890 T13385 T13378 prep in,reduced
R8891 T13386 T13387 det the,tissues
R8892 T13387 T13385 pobj tissues,in
R8893 T13388 T13387 compound CNS,tissues
R8894 T13389 T13387 punct (,tissues
R8895 T13390 T13387 appos brain,tissues
R8896 T13391 T13390 cc and,brain
R8897 T13392 T13390 conj retina,brain
R8898 T13393 T13385 punct ),in
R8899 T13394 T13385 cc but,in
R8900 T13395 T13394 neg not,but
R8901 T13396 T13385 conj in,in
R8902 T13397 T13398 amod non-neuronal,tissues
R8903 T13398 T13396 pobj tissues,in
R8904 T13399 T13398 acl tested,tissues
R8905 T13400 T13398 punct (,tissues
R8906 T13401 T13402 advmod e.g.,spleen
R8907 T13402 T13398 appos spleen,tissues
R8908 T13403 T13402 punct ", ",spleen
R8909 T13404 T13378 punct ),reduced
R8910 T13405 T13378 punct .,reduced
R8911 T13498 T13499 nmod RanBP2,Mice
R8912 T13499 T13503 nsubj Mice,Exhibit
R8913 T13500 T13498 punct +,RanBP2
R8914 T13501 T13498 punct /,RanBP2
R8915 T13502 T13498 punct −,RanBP2
R8916 T13504 T13499 prep on,Mice
R8917 T13505 T13506 amod High,Fat
R8918 T13506 T13508 compound Fat,Diet
R8919 T13507 T13506 punct -,Fat
R8920 T13508 T13504 pobj Diet,on
R8921 T13509 T13503 dobj Deficits,Exhibit
R8922 T13510 T13509 prep in,Deficits
R8923 T13511 T13510 pobj Growth,in
R8924 T13513 T13514 punct (,A
R8925 T13514 T13515 meta A,show
R8926 T13516 T13514 punct ),A
R8927 T13517 T13515 prep In,show
R8928 T13518 T13517 pobj comparison,In
R8929 T13519 T13518 prep to,comparison
R8930 T13520 T13521 amod wild,type
R8931 T13521 T13523 compound type,mice
R8932 T13522 T13521 punct -,type
R8933 T13523 T13519 pobj mice,to
R8934 T13524 T13515 punct ", ",show
R8935 T13525 T13526 nmod RanBP2,mice
R8936 T13526 T13515 nsubj mice,show
R8937 T13527 T13525 punct +,RanBP2
R8938 T13528 T13525 punct /,RanBP2
R8939 T13529 T13525 punct −,RanBP2
R8940 T13530 T13531 amod slower,rates
R8941 T13531 T13515 dobj rates,show
R8942 T13532 T13531 compound growth,rates
R8943 T13533 T13515 advcl beginning,show
R8944 T13534 T13533 prep at,beginning
R8945 T13535 T13536 nummod 4,mo
R8946 T13536 T13534 pobj mo,at
R8947 T13537 T13536 prep of,mo
R8948 T13538 T13537 pobj age,of
R8949 T13539 T13540 punct (,arrow
R8950 T13540 T13515 parataxis arrow,show
R8951 T13541 T13540 punct ),arrow
R8952 T13542 T13515 punct ", ",show
R8953 T13543 T13515 cc and,show
R8954 T13544 T13545 det the,difference
R8955 T13545 T13546 nsubjpass difference,maintained
R8956 T13546 T13515 conj maintained,show
R8957 T13547 T13545 prep in,difference
R8958 T13548 T13549 compound body,weight
R8959 T13549 T13547 pobj weight,in
R8960 T13550 T13545 prep between,difference
R8961 T13551 T13550 pobj these,between
R8962 T13552 T13546 auxpass is,maintained
R8963 T13553 T13546 advmod afterward,maintained
R8964 T13554 T13546 punct .,maintained
R8965 T13557 T13558 mark that,lack
R8966 T13558 T13556 ccomp lack,Note
R8967 T13559 T13560 nmod RanBP2,mice
R8968 T13560 T13558 nsubj mice,lack
R8969 T13561 T13559 punct +,RanBP2
R8970 T13562 T13559 punct /,RanBP2
R8971 T13563 T13559 punct −,RanBP2
R8972 T13564 T13565 det the,spur
R8973 T13565 T13558 dobj spur,lack
R8974 T13566 T13565 compound growth,spur
R8975 T13567 T13565 acl observed,spur
R8976 T13568 T13567 prep in,observed
R8977 T13569 T13570 amod wild,type
R8978 T13570 T13572 compound type,mice
R8979 T13571 T13570 punct -,type
R8980 T13572 T13568 pobj mice,in
R8981 T13573 T13572 prep between,mice
R8982 T13574 T13575 nummod 3,mo
R8983 T13575 T13573 pobj mo,between
R8984 T13576 T13574 cc and,3
R8985 T13577 T13574 conj 4,3
R8986 T13578 T13575 prep of,mo
R8987 T13579 T13578 pobj age,of
R8988 T13580 T13556 punct .,Note
R8989 T13582 T13583 punct (,B
R8990 T13583 T13584 meta B,masked
R8991 T13585 T13583 punct ),B
R8992 T13586 T13584 prep In,masked
R8993 T13587 T13586 pobj comparison,In
R8994 T13588 T13587 prep to,comparison
R8995 T13589 T13590 amod inbred,mice
R8996 T13590 T13588 pobj mice,to
R8997 T13591 T13590 nmod RanBP2,mice
R8998 T13592 T13591 punct +,RanBP2
R8999 T13593 T13591 punct /,RanBP2
R9000 T13594 T13591 punct −,RanBP2
R9001 T13595 T13590 punct (,mice
R9002 T13596 T13597 nmod 129Ola,background
R9003 T13597 T13590 appos background,mice
R9004 T13598 T13597 amod genetic,background
R9005 T13599 T13584 punct ),masked
R9006 T13600 T13584 punct ", ",masked
R9007 T13601 T13602 det the,difference
R9008 T13602 T13584 nsubjpass difference,masked
R9009 T13603 T13602 prep in,difference
R9010 T13604 T13605 compound body,weight
R9011 T13605 T13603 pobj weight,in
R9012 T13606 T13602 prep between,difference
R9013 T13607 T13608 nmod RanBP2,mice
R9014 T13608 T13606 pobj mice,between
R9015 T13609 T13607 punct +,RanBP2
R9016 T13610 T13607 punct /,RanBP2
R9017 T13611 T13607 punct +,RanBP2
R9018 T13612 T13607 cc and,RanBP2
R9019 T13613 T13607 conj RanBP2,RanBP2
R9020 T13614 T13613 punct +,RanBP2
R9021 T13615 T13613 punct /,RanBP2
R9022 T13616 T13613 punct −,RanBP2
R9023 T13617 T13584 auxpass is,masked
R9024 T13618 T13584 prep upon,masked
R9025 T13619 T13618 pcomp placing,upon
R9026 T13620 T13619 dobj these,placing
R9027 T13621 T13619 prep on,placing
R9028 T13622 T13623 det a,background
R9029 T13623 T13621 pobj background,on
R9030 T13624 T13623 amod mixed,background
R9031 T13625 T13626 nmod 129Ola,C57Bl6
R9032 T13626 T13623 nmod C57Bl6,background
R9033 T13627 T13626 punct /,C57Bl6
R9034 T13628 T13623 amod genetic,background
R9035 T13629 T13584 punct .,masked
R9036 T13631 T13632 punct (,C
R9037 T13632 T13633 meta C,exhibit
R9038 T13634 T13632 punct ),C
R9039 T13635 T13636 nmod RanBP2,mice
R9040 T13636 T13633 nsubj mice,exhibit
R9041 T13637 T13635 punct +,RanBP2
R9042 T13638 T13635 punct /,RanBP2
R9043 T13639 T13635 punct +,RanBP2
R9044 T13640 T13635 cc and,RanBP2
R9045 T13641 T13635 conj RanBP2,RanBP2
R9046 T13642 T13641 punct +,RanBP2
R9047 T13643 T13641 punct /,RanBP2
R9048 T13644 T13641 punct −,RanBP2
R9049 T13645 T13636 amod inbred,mice
R9050 T13646 T13647 amod similar,rates
R9051 T13647 T13633 dobj rates,exhibit
R9052 T13648 T13647 prep of,rates
R9053 T13649 T13650 compound food,consumption
R9054 T13650 T13648 pobj consumption,of
R9055 T13651 T13633 punct .,exhibit
R9056 T13653 T13654 nsubjpass Mice,placed
R9057 T13655 T13653 prep in,Mice
R9058 T13656 T13655 punct (,in
R9059 T13657 T13655 pobj A,in
R9060 T13658 T13657 punct ),A
R9061 T13659 T13657 punct ", ",A
R9062 T13660 T13661 punct (,B
R9063 T13661 T13657 conj B,A
R9064 T13662 T13661 punct ),B
R9065 T13663 T13661 punct ", ",B
R9066 T13664 T13661 cc and,B
R9067 T13665 T13666 punct (,C
R9068 T13666 T13661 conj C,B
R9069 T13667 T13654 punct ),placed
R9070 T13668 T13654 auxpass were,placed
R9071 T13669 T13654 prep on,placed
R9072 T13670 T13671 det a,diet
R9073 T13671 T13669 pobj diet,on
R9074 T13672 T13673 amod high,fat
R9075 T13673 T13671 compound fat,diet
R9076 T13674 T13673 punct -,fat
R9077 T13675 T13654 prep since,placed
R9078 T13676 T13675 pobj birth,since
R9079 T13677 T13678 punct (,5
R9080 T13678 T13654 parataxis 5,placed
R9081 T13679 T13678 nsubj n,5
R9082 T13680 T13678 punct =,5
R9083 T13681 T13678 punct ),5
R9084 T13682 T13654 punct .,placed
R9085 T13772 T13773 amod Metabolic,Phenotypes
R9086 T13774 T13773 prep of,Phenotypes
R9087 T13775 T13776 nmod RanBP2,Mice
R9088 T13776 T13774 pobj Mice,of
R9089 T13777 T13775 punct +,RanBP2
R9090 T13778 T13775 punct /,RanBP2
R9091 T13779 T13775 punct −,RanBP2
R9092 T13780 T13776 amod Inbred,Mice
R9093 T13781 T13776 prep on,Mice
R9094 T13782 T13783 amod High,Fat
R9095 T13783 T13785 compound Fat,Diet
R9096 T13784 T13783 punct -,Fat
R9097 T13785 T13781 pobj Diet,on
R9098 T13787 T13788 punct (,A
R9099 T13788 T13789 meta A,have
R9100 T13790 T13788 punct ),A
R9101 T13791 T13792 nummod 3,mo
R9102 T13792 T13794 npadvmod mo,old
R9103 T13793 T13792 punct -,mo
R9104 T13794 T13796 amod old,mice
R9105 T13795 T13794 punct -,old
R9106 T13796 T13789 nsubj mice,have
R9107 T13797 T13796 amod inbred,mice
R9108 T13798 T13796 nmod RanBP2,mice
R9109 T13799 T13798 punct +,RanBP2
R9110 T13800 T13798 punct /,RanBP2
R9111 T13801 T13798 punct −,RanBP2
R9112 T13802 T13803 punct (,5
R9113 T13803 T13796 parataxis 5,mice
R9114 T13804 T13803 nsubj n,5
R9115 T13805 T13803 punct =,5
R9116 T13806 T13803 punct ),5
R9117 T13807 T13808 amod normal,rates
R9118 T13808 T13789 dobj rates,have
R9119 T13809 T13810 compound glucose,clearance
R9120 T13810 T13808 compound clearance,rates
R9121 T13811 T13789 prep upon,have
R9122 T13812 T13813 compound glucose,challenge
R9123 T13813 T13811 pobj challenge,upon
R9124 T13814 T13813 cc and,challenge
R9125 T13815 T13816 amod overnight,fasting
R9126 T13816 T13813 conj fasting,challenge
R9127 T13817 T13789 punct .,have
R9128 T13819 T13820 punct (,B
R9129 T13820 T13821 meta B,have
R9130 T13822 T13820 punct ),B
R9131 T13823 T13821 prep In,have
R9132 T13824 T13823 pobj contrast,In
R9133 T13825 T13821 punct ", ",have
R9134 T13826 T13827 nummod 6,mo
R9135 T13827 T13829 npadvmod mo,old
R9136 T13828 T13827 punct -,mo
R9137 T13829 T13831 amod old,mice
R9138 T13830 T13829 punct -,old
R9139 T13831 T13821 nsubj mice,have
R9140 T13832 T13831 amod inbred,mice
R9141 T13833 T13831 nmod RanBP2,mice
R9142 T13834 T13833 punct +,RanBP2
R9143 T13835 T13833 punct /,RanBP2
R9144 T13836 T13833 punct −,RanBP2
R9145 T13837 T13838 punct (,5
R9146 T13838 T13831 parataxis 5,mice
R9147 T13839 T13838 nsubj n,5
R9148 T13840 T13838 punct =,5
R9149 T13841 T13838 punct ),5
R9150 T13842 T13843 advmod significantly,decreased
R9151 T13843 T13844 amod decreased,rates
R9152 T13844 T13821 dobj rates,have
R9153 T13845 T13846 compound glucose,clearance
R9154 T13846 T13844 compound clearance,rates
R9155 T13847 T13821 prep upon,have
R9156 T13848 T13849 compound glucose,challenge
R9157 T13849 T13847 pobj challenge,upon
R9158 T13850 T13849 cc and,challenge
R9159 T13851 T13852 amod overnight,fasting
R9160 T13852 T13849 conj fasting,challenge
R9161 T13853 T13821 punct .,have
R9162 T13855 T13856 punct (,C
R9163 T13856 T13857 meta C,have
R9164 T13858 T13856 punct ),C
R9165 T13859 T13860 amod Fasted,mice
R9166 T13860 T13857 nsubj mice,have
R9167 T13861 T13862 quantmod 6,8
R9168 T13862 T13865 nummod 8,mo
R9169 T13863 T13862 punct -,8
R9170 T13864 T13862 quantmod to,8
R9171 T13865 T13867 npadvmod mo,old
R9172 T13866 T13865 punct -,mo
R9173 T13867 T13860 amod old,mice
R9174 T13868 T13867 punct -,old
R9175 T13869 T13860 nmod RanBP2,mice
R9176 T13870 T13869 punct +,RanBP2
R9177 T13871 T13869 punct /,RanBP2
R9178 T13872 T13869 punct +,RanBP2
R9179 T13873 T13869 cc and,RanBP2
R9180 T13874 T13869 conj RanBP2,RanBP2
R9181 T13875 T13874 punct +,RanBP2
R9182 T13876 T13874 punct /,RanBP2
R9183 T13877 T13874 punct −,RanBP2
R9184 T13878 T13879 det no,difference
R9185 T13879 T13857 dobj difference,have
R9186 T13880 T13879 prep in,difference
R9187 T13881 T13882 npadvmod insulin,mediated
R9188 T13882 T13884 amod mediated,uptake
R9189 T13883 T13882 punct -,mediated
R9190 T13884 T13880 pobj uptake,in
R9191 T13885 T13884 compound glucose,uptake
R9192 T13886 T13887 mark as,assayed
R9193 T13887 T13857 advcl assayed,have
R9194 T13888 T13887 prep by,assayed
R9195 T13889 T13890 compound insulin,tolerance
R9196 T13890 T13891 compound tolerance,test
R9197 T13891 T13888 pobj test,by
R9198 T13892 T13893 punct (,5
R9199 T13893 T13857 parataxis 5,have
R9200 T13894 T13893 nsubj n,5
R9201 T13895 T13893 punct =,5
R9202 T13896 T13893 punct ),5
R9203 T13897 T13857 punct .,have
R9204 T13899 T13900 punct (,D
R9205 T13900 T13901 meta D,shows
R9206 T13902 T13900 punct ),D
R9207 T13903 T13904 compound Pyruvate,tolerance
R9208 T13904 T13905 compound tolerance,test
R9209 T13905 T13901 nsubj test,shows
R9210 T13906 T13907 amod normal,rise
R9211 T13907 T13901 dobj rise,shows
R9212 T13908 T13907 prep in,rise
R9213 T13909 T13908 pobj glucose,in
R9214 T13910 T13907 cc but,rise
R9215 T13911 T13912 amod decreased,clearance
R9216 T13912 T13907 conj clearance,rise
R9217 T13913 T13912 compound glucose,clearance
R9218 T13914 T13907 prep between,rise
R9219 T13915 T13916 amod inbred,mice
R9220 T13916 T13914 pobj mice,between
R9221 T13917 T13916 nmod RanBP2,mice
R9222 T13918 T13917 punct +,RanBP2
R9223 T13919 T13917 punct /,RanBP2
R9224 T13920 T13917 punct +,RanBP2
R9225 T13921 T13917 cc and,RanBP2
R9226 T13922 T13917 conj RanBP2,RanBP2
R9227 T13923 T13922 punct +,RanBP2
R9228 T13924 T13922 punct /,RanBP2
R9229 T13925 T13922 punct −,RanBP2
R9230 T13926 T13927 punct (,5
R9231 T13927 T13901 parataxis 5,shows
R9232 T13928 T13927 nsubj n,5
R9233 T13929 T13927 punct =,5
R9234 T13930 T13927 punct ),5
R9235 T13931 T13901 punct .,shows
R9244 T14066 T14065 prep from,Electroretinograms
R9245 T14067 T14068 nummod 6,Mo
R9246 T14068 T14070 npadvmod Mo,Old
R9247 T14069 T14068 punct -,Mo
R9248 T14070 T14072 amod Old,Mice
R9249 T14071 T14070 punct -,Old
R9250 T14072 T14066 pobj Mice,from
R9251 T14073 T14072 nmod RanBP2,Mice
R9252 T14074 T14073 punct +,RanBP2
R9253 T14075 T14073 punct /,RanBP2
R9254 T14076 T14073 punct −,RanBP2
R9255 T14077 T14073 cc and,RanBP2
R9256 T14078 T14073 conj RanBP2,RanBP2
R9257 T14079 T14078 punct +,RanBP2
R9258 T14080 T14078 punct /,RanBP2
R9259 T14081 T14078 punct +,RanBP2
R9260 T14082 T14072 amod Inbred,Mice
R9261 T14083 T14072 acl Showing,Mice
R9262 T14084 T14085 nmod Photoreceptor,Neuron
R9263 T14085 T14088 nmod Neuron,Phenotypes
R9264 T14086 T14084 cc and,Photoreceptor
R9265 T14087 T14084 conj Postreceptor,Photoreceptor
R9266 T14088 T14083 dobj Phenotypes,Showing
R9267 T14089 T14090 amod Electrophysiological,Response
R9268 T14090 T14088 compound Response,Phenotypes
R9269 T14092 T14093 punct (,A
R9270 T14093 T14094 meta A,have
R9271 T14095 T14093 punct ),A
R9272 T14096 T14097 amod Scotopic,responses
R9273 T14097 T14094 nsubj responses,have
R9274 T14098 T14099 punct (,adapted
R9275 T14099 T14096 parataxis adapted,Scotopic
R9276 T14100 T14099 dep dark,adapted
R9277 T14101 T14099 punct -,adapted
R9278 T14102 T14099 punct ),adapted
R9279 T14103 T14097 prep from,responses
R9280 T14104 T14105 nmod RanBP2,mice
R9281 T14105 T14103 pobj mice,from
R9282 T14106 T14104 punct +,RanBP2
R9283 T14107 T14104 punct /,RanBP2
R9284 T14108 T14104 punct −,RanBP2
R9285 T14109 T14097 prep to,responses
R9286 T14110 T14111 amod light,stimuli
R9287 T14111 T14109 pobj stimuli,to
R9288 T14112 T14111 prep of,stimuli
R9289 T14113 T14114 amod increasing,intensity
R9290 T14114 T14112 pobj intensity,of
R9291 T14115 T14094 punct ", ",have
R9292 T14116 T14094 advcl beginning,have
R9293 T14117 T14116 prep at,beginning
R9294 T14118 T14117 pobj threshold,at
R9295 T14119 T14094 punct ", ",have
R9296 T14120 T14121 amod reduced,amplitudes
R9297 T14121 T14094 dobj amplitudes,have
R9298 T14122 T14094 prep compared,have
R9299 T14123 T14122 prep to,compared
R9300 T14124 T14123 pobj those,to
R9301 T14125 T14124 acl observed,those
R9302 T14126 T14125 prep in,observed
R9303 T14127 T14128 nmod RanBP2,mice
R9304 T14128 T14126 pobj mice,in
R9305 T14129 T14127 punct +,RanBP2
R9306 T14130 T14127 punct /,RanBP2
R9307 T14131 T14127 punct +,RanBP2
R9308 T14132 T14094 punct .,have
R9309 T14134 T14135 det The,intensities
R9310 T14135 T14138 nsubj intensities,represent
R9311 T14136 T14135 nummod three,intensities
R9312 T14137 T14135 amod lower,intensities
R9313 T14139 T14138 dobj responses,represent
R9314 T14140 T14139 acl generated,responses
R9315 T14141 T14140 prep in,generated
R9316 T14142 T14143 det the,pathway
R9317 T14143 T14141 pobj pathway,in
R9318 T14144 T14145 nmod rod,photoreceptor
R9319 T14145 T14143 nmod photoreceptor,pathway
R9320 T14146 T14143 amod neuronal,pathway
R9321 T14147 T14138 punct .,represent
R9322 T14149 T14150 det The,intensities
R9323 T14150 T14152 nsubjpass intensities,comprised
R9324 T14151 T14150 amod upper,intensities
R9325 T14153 T14152 auxpass are,comprised
R9326 T14154 T14152 prep of,comprised
R9327 T14155 T14154 pobj responses,of
R9328 T14156 T14155 acl generated,responses
R9329 T14157 T14156 prep in,generated
R9330 T14158 T14159 preconj both,pathways
R9331 T14159 T14157 pobj pathways,in
R9332 T14160 T14159 det the,pathways
R9333 T14161 T14159 nmod rod,pathways
R9334 T14162 T14161 cc and,rod
R9335 T14163 T14161 conj cone,rod
R9336 T14164 T14152 punct .,comprised
R9337 T14166 T14167 punct (,B
R9338 T14167 T14168 meta B,exhibited
R9339 T14169 T14167 punct ),B
R9340 T14170 T14171 amod Photopic,responses
R9341 T14171 T14168 nsubj responses,exhibited
R9342 T14172 T14173 punct (,pathway
R9343 T14173 T14170 parataxis pathway,Photopic
R9344 T14174 T14175 npadvmod light,adapted
R9345 T14175 T14173 amod adapted,pathway
R9346 T14176 T14175 punct -,adapted
R9347 T14177 T14173 punct ", ",pathway
R9348 T14178 T14179 compound cone,photoreceptor
R9349 T14179 T14173 compound photoreceptor,pathway
R9350 T14180 T14173 punct ),pathway
R9351 T14181 T14171 prep of,responses
R9352 T14182 T14183 nmod RanBP2,mice
R9353 T14183 T14181 pobj mice,of
R9354 T14184 T14182 punct +,RanBP2
R9355 T14185 T14182 punct /,RanBP2
R9356 T14186 T14182 punct −,RanBP2
R9357 T14187 T14171 prep to,responses
R9358 T14188 T14189 amod increasing,intensities
R9359 T14189 T14187 pobj intensities,to
R9360 T14190 T14191 amod light,stimulus
R9361 T14191 T14189 compound stimulus,intensities
R9362 T14192 T14168 advmod also,exhibited
R9363 T14193 T14194 amod reduced,amplitudes
R9364 T14194 T14168 dobj amplitudes,exhibited
R9365 T14195 T14168 prep compared,exhibited
R9366 T14196 T14195 prep to,compared
R9367 T14197 T14196 pobj those,to
R9368 T14198 T14197 acl observed,those
R9369 T14199 T14198 prep in,observed
R9370 T14200 T14201 nmod RanBP2,mice
R9371 T14201 T14199 pobj mice,in
R9372 T14202 T14200 punct +,RanBP2
R9373 T14203 T14200 punct /,RanBP2
R9374 T14204 T14200 punct +,RanBP2
R9375 T14205 T14168 punct .,exhibited
R9376 T14207 T14208 punct (,C
R9377 T14208 T14209 meta C,amplitudes
R9378 T14210 T14208 punct ),C
R9379 T14211 T14212 nmod Average,SE
R9380 T14212 T14209 nmod SE,amplitudes
R9381 T14213 T14212 punct ±,SE
R9382 T14214 T14215 punct (,9
R9383 T14215 T14212 parataxis 9,SE
R9384 T14216 T14215 nsubj n,9
R9385 T14217 T14215 punct =,9
R9386 T14218 T14215 punct ),9
R9387 T14219 T14209 amod scotopic,amplitudes
R9388 T14220 T14221 compound b,wave
R9389 T14221 T14209 compound wave,amplitudes
R9390 T14222 T14221 punct -,wave
R9391 T14223 T14209 prep from,amplitudes
R9392 T14224 T14225 nmod RanBP2,mice
R9393 T14225 T14223 pobj mice,from
R9394 T14226 T14224 punct +,RanBP2
R9395 T14227 T14224 punct /,RanBP2
R9396 T14228 T14224 punct −,RanBP2
R9397 T14229 T14230 punct (,circles
R9398 T14230 T14224 parataxis circles,RanBP2
R9399 T14231 T14230 amod open,circles
R9400 T14232 T14230 punct ),circles
R9401 T14233 T14224 cc and,RanBP2
R9402 T14234 T14224 conj RanBP2,RanBP2
R9403 T14235 T14234 punct +,RanBP2
R9404 T14236 T14234 punct /,RanBP2
R9405 T14237 T14234 punct +,RanBP2
R9406 T14238 T14239 punct (,squares
R9407 T14239 T14234 parataxis squares,RanBP2
R9408 T14240 T14239 amod filled,squares
R9409 T14241 T14239 punct ),squares
R9410 T14242 T14209 acl representing,amplitudes
R9411 T14243 T14244 amod postreceptoral,neuron
R9412 T14244 T14245 compound neuron,function
R9413 T14245 T14242 dobj function,representing
R9414 T14246 T14209 punct .,amplitudes
R9415 T14248 T14249 punct (,scale
R9416 T14250 T14249 dep Note,scale
R9417 T14251 T14249 punct : ,scale
R9418 T14252 T14253 compound log,amplitude
R9419 T14253 T14249 compound amplitude,scale
R9420 T14254 T14249 punct .,scale
R9421 T14255 T14249 punct ),scale
R9422 T14257 T14258 punct (,D
R9423 T14258 T14259 meta D,amplitudes
R9424 T14260 T14258 punct ),D
R9425 T14261 T14262 amod Average,SE
R9426 T14262 T14259 nmod SE,amplitudes
R9427 T14263 T14262 punct ±,SE
R9428 T14264 T14265 punct (,5
R9429 T14265 T14262 parataxis 5,SE
R9430 T14266 T14265 nsubj n,5
R9431 T14267 T14265 punct =,5
R9432 T14268 T14265 punct ),5
R9433 T14269 T14259 amod scotopic,amplitudes
R9434 T14270 T14271 compound a,wave
R9435 T14271 T14259 compound wave,amplitudes
R9436 T14272 T14271 punct -,wave
R9437 T14273 T14259 punct ", ",amplitudes
R9438 T14274 T14259 acl representing,amplitudes
R9439 T14275 T14276 compound photoreceptor,function
R9440 T14276 T14274 dobj function,representing
R9441 T14277 T14274 punct ", ",representing
R9442 T14278 T14274 prep for,representing
R9443 T14279 T14280 nmod RanBP2,mice
R9444 T14280 T14278 pobj mice,for
R9445 T14281 T14279 punct +,RanBP2
R9446 T14282 T14279 punct /,RanBP2
R9447 T14283 T14279 punct −,RanBP2
R9448 T14284 T14279 cc and,RanBP2
R9449 T14285 T14279 conj RanBP2,RanBP2
R9450 T14286 T14285 punct +,RanBP2
R9451 T14287 T14285 punct /,RanBP2
R9452 T14288 T14285 punct +,RanBP2
R9453 T14289 T14274 prep in,representing
R9454 T14290 T14289 pobj response,in
R9455 T14291 T14290 prep to,response
R9456 T14292 T14293 amod bright,flashes
R9457 T14293 T14291 pobj flashes,to
R9458 T14294 T14259 punct .,amplitudes
R9459 T14296 T14297 nsubj Amplitudes,were
R9460 T14298 T14296 prep of,Amplitudes
R9461 T14299 T14298 pobj responses,of
R9462 T14300 T14299 prep from,responses
R9463 T14301 T14302 nmod RanBP2,mice
R9464 T14302 T14300 pobj mice,from
R9465 T14303 T14301 punct +,RanBP2
R9466 T14304 T14301 punct /,RanBP2
R9467 T14305 T14301 punct −,RanBP2
R9468 T14306 T14297 acomp lower,were
R9469 T14307 T14297 prep over,were
R9470 T14308 T14309 det the,range
R9471 T14309 T14307 pobj range,over
R9472 T14310 T14309 amod entire,range
R9473 T14311 T14309 prep of,range
R9474 T14312 T14313 compound stimulus,intensities
R9475 T14313 T14311 pobj intensities,of
R9476 T14314 T14313 prep for,intensities
R9477 T14315 T14316 preconj both,b
R9478 T14316 T14317 nmod b,waves
R9479 T14317 T14314 pobj waves,for
R9480 T14318 T14316 punct -,b
R9481 T14319 T14316 cc and,b
R9482 T14320 T14316 conj a,b
R9483 T14321 T14320 punct -,a
R9484 T14322 T14297 punct .,were
R9485 T14324 T14325 nsubj Asterisks,represent
R9486 T14326 T14327 amod significant,differences
R9487 T14327 T14325 dobj differences,represent
R9488 T14328 T14327 prep between,differences
R9489 T14329 T14330 det the,groups
R9490 T14330 T14328 pobj groups,between
R9491 T14331 T14332 punct (,test
R9492 T14332 T14325 parataxis test,represent
R9493 T14333 T14332 poss Student,test
R9494 T14334 T14333 case 's,Student
R9495 T14335 T14332 compound t,test
R9496 T14336 T14332 punct ", ",test
R9497 T14337 T14338 nsubj p,0.05
R9498 T14338 T14332 ccomp 0.05,test
R9499 T14339 T14338 punct <,0.05
R9500 T14340 T14332 punct ),test
R9501 T14341 T14325 punct .,represent
R9502 T14343 T14344 amod Statistical,significance
R9503 T14344 T14345 nsubjpass significance,found
R9504 T14346 T14345 auxpass was,found
R9505 T14347 T14345 prep across,found
R9506 T14348 T14349 det all,intensities
R9507 T14349 T14347 pobj intensities,across
R9508 T14350 T14345 prep for,found
R9509 T14351 T14352 compound b,wave
R9510 T14352 T14354 compound wave,amplitudes
R9511 T14353 T14352 punct -,wave
R9512 T14354 T14350 pobj amplitudes,for
R9513 T14355 T14356 punct (,ANOVA
R9514 T14356 T14354 parataxis ANOVA,amplitudes
R9515 T14357 T14358 nummod 2,way
R9516 T14358 T14356 compound way,ANOVA
R9517 T14359 T14358 punct -,way
R9518 T14360 T14356 punct ", ",ANOVA
R9519 T14361 T14362 nsubj p,0.0001
R9520 T14362 T14356 ccomp 0.0001,ANOVA
R9521 T14363 T14362 punct <,0.0001
R9522 T14364 T14356 punct ),ANOVA
R9523 T14365 T14350 punct ", ",for
R9524 T14366 T14350 cc but,for
R9525 T14367 T14366 neg not,but
R9526 T14368 T14350 conj for,for
R9527 T14369 T14370 det the,wave
R9528 T14370 T14368 pobj wave,for
R9529 T14371 T14370 compound a,wave
R9530 T14372 T14370 punct -,wave
R9531 T14373 T14345 punct .,found