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PMC:1626108 / 39734-41172 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7457 7-9 , denotes ,
T7458 9-15 NN denotes RanBP2
T7456 16-23 VBZ denotes appears
T7459 24-26 TO denotes to
T7460 27-31 VB denotes join
T7461 32-37 JJ denotes other
T7462 38-50 NNS denotes nucleoporins
T7463 50-52 , denotes ,
T7464 52-56 JJ denotes such
T7465 57-59 IN denotes as
T7466 60-65 NN denotes Nup96
T7467 66-67 -LRB- denotes [
T7468 67-69 CD denotes 58
T7469 69-70 -RRB- denotes ]
T7470 70-72 , denotes ,
T7471 72-74 IN denotes in
T7472 75-80 JJ denotes novel
T7474 81-94 JJ denotes physiological
T7473 95-104 NNS denotes functions
T7475 105-109 WDT denotes that
T7476 110-113 VBP denotes are
T7477 114-119 JJ denotes vital
T7478 120-123 IN denotes for
T7479 124-131 JJ denotes complex
T7480 132-141 NNS denotes organisms
T7481 142-145 CC denotes and
T7482 146-150 WDT denotes that
T7484 151-155 VBD denotes were
T7485 156-159 RB denotes not
T7483 160-171 VBN denotes anticipated
T7486 172-176 IN denotes from
T7487 177-181 NN denotes cell
T7489 181-182 HYPH denotes -
T7488 182-187 VBN denotes based
T7490 188-195 NNS denotes studies
T7491 195-196 . denotes .
T7492 196-435 sentence denotes The reduced expression of these proteins in whole-animal models generates phenotypes that are tissue-restricted and more importantly, do not seem to recapitulate phenotypes observed with knockdown experiments in cell-based culture assays.
T7493 197-200 DT denotes The
T7495 201-208 VBN denotes reduced
T7494 209-219 NN denotes expression
T7497 220-222 IN denotes of
T7498 223-228 DT denotes these
T7499 229-237 NN denotes proteins
T7500 238-240 IN denotes in
T7501 241-246 JJ denotes whole
T7503 246-247 HYPH denotes -
T7502 247-253 NN denotes animal
T7504 254-260 NNS denotes models
T7496 261-270 VBZ denotes generates
T7505 271-281 NNS denotes phenotypes
T7506 282-286 WDT denotes that
T7507 287-290 VBP denotes are
T7508 291-297 NN denotes tissue
T7510 297-298 HYPH denotes -
T7509 298-308 JJ denotes restricted
T7511 309-312 CC denotes and
T7512 313-317 RBR denotes more
T7513 318-329 RB denotes importantly
T7515 329-331 , denotes ,
T7516 331-333 VBP denotes do
T7517 334-337 RB denotes not
T7514 338-342 VB denotes seem
T7518 343-345 TO denotes to
T7519 346-358 VB denotes recapitulate
T7520 359-369 NNS denotes phenotypes
T7521 370-378 VBN denotes observed
T7522 379-383 IN denotes with
T7523 384-393 NN denotes knockdown
T7524 394-405 NNS denotes experiments
T7525 406-408 IN denotes in
T7526 409-413 NN denotes cell
T7528 413-414 HYPH denotes -
T7527 414-419 VBN denotes based
T7530 420-427 NN denotes culture
T7529 428-434 NNS denotes assays
T7531 434-435 . denotes .
T7532 435-687 sentence denotes For example, short interfering RNA-mediated knockdown of RanBP2 [9] and members of the Nup107-Nup160 complex [59–61] have shown, respectively, to cause mitotic arrest and disruption of nuclear pore assembly and deficits in mRNA export in cell culture.
T7533 436-439 IN denotes For
T7535 440-447 NN denotes example
T7536 447-449 , denotes ,
T7537 449-454 JJ denotes short
T7539 455-466 VBG denotes interfering
T7540 467-470 NN denotes RNA
T7542 470-471 HYPH denotes -
T7541 471-479 VBN denotes mediated
T7538 480-489 NN denotes knockdown
T7543 490-492 IN denotes of
T7544 493-499 NN denotes RanBP2
T7545 500-501 -LRB- denotes [
T7546 501-502 CD denotes 9
T7547 502-503 -RRB- denotes ]
T7548 504-507 CC denotes and
T7549 508-515 NNS denotes members
T7550 516-518 IN denotes of
T7551 519-522 DT denotes the
T7553 523-529 NN denotes Nup107
T7555 529-530 HYPH denotes -
T7554 530-536 NN denotes Nup160
T7552 537-544 NN denotes complex
T7556 545-546 -LRB- denotes [
T7557 546-548 CD denotes 59
T7558 548-549 SYM denotes –
T7559 549-551 CD denotes 61
T7560 551-552 -RRB- denotes ]
T7561 553-557 VBP denotes have
T7534 558-563 VBN denotes shown
T7562 563-565 , denotes ,
T7563 565-577 RB denotes respectively
T7564 577-579 , denotes ,
T7565 579-581 TO denotes to
T7566 582-587 VB denotes cause
T7567 588-595 JJ denotes mitotic
T7568 596-602 NN denotes arrest
T7569 603-606 CC denotes and
T7570 607-617 NN denotes disruption
T7571 618-620 IN denotes of
T7572 621-628 JJ denotes nuclear
T7573 629-633 NN denotes pore
T7574 634-642 NN denotes assembly
T7575 643-646 CC denotes and
T7576 647-655 NNS denotes deficits
T7577 656-658 IN denotes in
T7578 659-663 NN denotes mRNA
T7579 664-670 NN denotes export
T7580 671-673 IN denotes in
T7581 674-678 NN denotes cell
T7582 679-686 NN denotes culture
T7583 686-687 . denotes .
T7584 687-990 sentence denotes Yet, haploinsufficiency of RanBP2 (this work) and Nup96 [58] predominantly produce, instead, CNS-restricted deficits in energy metabolism and alterations in the immune system linked to the down-regulation of interferon-β-regulated proteins and increased susceptibility of viral infection, respectively.
T7585 688-691 RB denotes Yet
T7587 691-693 , denotes ,
T7588 693-711 NN denotes haploinsufficiency
T7589 712-714 IN denotes of
T7590 715-721 NN denotes RanBP2
T7591 722-723 -LRB- denotes (
T7593 723-727 DT denotes this
T7592 728-732 NN denotes work
T7594 732-733 -RRB- denotes )
T7595 734-737 CC denotes and
T7596 738-743 NN denotes Nup96
T7597 744-745 -LRB- denotes [
T7598 745-747 CD denotes 58
T7599 747-748 -RRB- denotes ]
T7600 749-762 RB denotes predominantly
T7586 763-770 VBP denotes produce
T7601 770-772 , denotes ,
T7602 772-779 RB denotes instead
T7603 779-781 , denotes ,
T7604 781-784 NN denotes CNS
T7606 784-785 HYPH denotes -
T7605 785-795 JJ denotes restricted
T7607 796-804 NNS denotes deficits
T7608 805-807 IN denotes in
T7609 808-814 NN denotes energy
T7610 815-825 NN denotes metabolism
T7611 826-829 CC denotes and
T7612 830-841 NNS denotes alterations
T7613 842-844 IN denotes in
T7614 845-848 DT denotes the
T7616 849-855 JJ denotes immune
T7615 856-862 NN denotes system
T7617 863-869 VBN denotes linked
T7618 870-872 IN denotes to
T7619 873-876 DT denotes the
T7621 877-881 JJ denotes down
T7622 881-882 HYPH denotes -
T7620 882-892 NN denotes regulation
T7623 893-895 IN denotes of
T7624 896-906 NN denotes interferon
T7626 906-907 HYPH denotes -
T7625 907-908 NN denotes β
T7628 908-909 HYPH denotes -
T7627 909-918 VBN denotes regulated
T7629 919-927 NN denotes proteins
T7630 928-931 CC denotes and
T7631 932-941 VBN denotes increased
T7632 942-956 NN denotes susceptibility
T7633 957-959 IN denotes of
T7634 960-965 JJ denotes viral
T7635 966-975 NN denotes infection
T7636 975-977 , denotes ,
T7637 977-989 RB denotes respectively
T7638 989-990 . denotes .
T7639 990-1202 sentence denotes While these apparent outcome disparities among experimental systems remain unclear, they could potentially result from variations in redundancies and compensatory mechanisms inherent to each experimental system.
T7640 991-996 IN denotes While
T7642 997-1002 DT denotes these
T7644 1003-1011 JJ denotes apparent
T7645 1012-1019 NN denotes outcome
T7643 1020-1031 NNS denotes disparities
T7646 1032-1037 IN denotes among
T7647 1038-1050 JJ denotes experimental
T7648 1051-1058 NNS denotes systems
T7641 1059-1065 VBP denotes remain
T7650 1066-1073 JJ denotes unclear
T7651 1073-1075 , denotes ,
T7652 1075-1079 PRP denotes they
T7653 1080-1085 MD denotes could
T7654 1086-1097 RB denotes potentially
T7649 1098-1104 VB denotes result
T7655 1105-1109 IN denotes from
T7656 1110-1120 NNS denotes variations
T7657 1121-1123 IN denotes in
T7658 1124-1136 NNS denotes redundancies
T7659 1137-1140 CC denotes and
T7660 1141-1153 JJ denotes compensatory
T7661 1154-1164 NNS denotes mechanisms
T7662 1165-1173 JJ denotes inherent
T7663 1174-1176 IN denotes to
T7664 1177-1181 DT denotes each
T7666 1182-1194 JJ denotes experimental
T7665 1195-1201 NN denotes system
T7667 1201-1202 . denotes .
T7668 1202-1438 sentence denotes Regardless, these genetic and whole-animal models set the stage to probe novel molecular pathways in various physiological and genetic contexts, and provide also a link to pathophysiological processes underlying several human diseases.
T7669 1203-1213 RB denotes Regardless
T7671 1213-1215 , denotes ,
T7672 1215-1220 DT denotes these
T7674 1221-1228 JJ denotes genetic
T7675 1229-1232 CC denotes and
T7676 1233-1238 JJ denotes whole
T7678 1238-1239 HYPH denotes -
T7677 1239-1245 NN denotes animal
T7673 1246-1252 NNS denotes models
T7670 1253-1256 VBD denotes set
T7679 1257-1260 DT denotes the
T7680 1261-1266 NN denotes stage
T7681 1267-1269 TO denotes to
T7682 1270-1275 VB denotes probe
T7683 1276-1281 JJ denotes novel
T7685 1282-1291 JJ denotes molecular
T7684 1292-1300 NNS denotes pathways
T7686 1301-1303 IN denotes in
T7687 1304-1311 JJ denotes various
T7689 1312-1325 JJ denotes physiological
T7690 1326-1329 CC denotes and
T7691 1330-1337 JJ denotes genetic
T7688 1338-1346 NNS denotes contexts
T7692 1346-1348 , denotes ,
T7693 1348-1351 CC denotes and
T7694 1352-1359 VB denotes provide
T7695 1360-1364 RB denotes also
T7696 1365-1366 DT denotes a
T7697 1367-1371 NN denotes link
T7698 1372-1374 IN denotes to
T7699 1375-1393 JJ denotes pathophysiological
T7700 1394-1403 NNS denotes processes
T7701 1404-1414 VBG denotes underlying
T7702 1415-1422 JJ denotes several
T7704 1423-1428 JJ denotes human
T7703 1429-1437 NNS denotes diseases
T7705 1437-1438 . denotes .
R4768 T7457 T7456 punct ", ",appears
R4769 T7458 T7456 nsubj RanBP2,appears
R4771 T7459 T7460 aux to,join
R4772 T7460 T7456 xcomp join,appears
R4774 T7461 T7462 amod other,nucleoporins
R4775 T7462 T7460 dobj nucleoporins,join
R4776 T7463 T7462 punct ", ",nucleoporins
R4778 T7464 T7465 amod such,as
R4780 T7465 T7462 prep as,nucleoporins
R4781 T7466 T7465 pobj Nup96,as
R4782 T7467 T7468 punct [,58
R4786 T7468 T7460 parataxis 58,join
R4787 T7469 T7468 punct ],58
R4788 T7470 T7460 punct ", ",join
R4790 T7471 T7460 prep in,join
R4791 T7472 T7473 amod novel,functions
R4792 T7473 T7471 pobj functions,in
R4794 T7474 T7473 amod physiological,functions
R4795 T7475 T7476 dep that,are
R4796 T7476 T7473 advcl are,functions
R4798 T7477 T7476 acomp vital,are
R4799 T7478 T7477 prep for,vital
R4801 T7479 T7480 amod complex,organisms
R4802 T7480 T7478 pobj organisms,for
R4803 T7481 T7476 cc and,are
R4805 T7482 T7483 dep that,anticipated
R4806 T7483 T7476 conj anticipated,are
R4807 T7484 T7483 auxpass were,anticipated
R4809 T7485 T7483 neg not,anticipated
R4810 T7486 T7483 prep from,anticipated
R4811 T7487 T7488 npadvmod cell,based
R4813 T7488 T7490 amod based,studies
R4814 T7489 T7488 punct -,based
R4815 T7490 T7486 pobj studies,from
R4817 T7491 T7456 punct .,appears
R4819 T7493 T7494 det The,expression
R4820 T7494 T7496 nsubj expression,generates
R4821 T7495 T7494 amod reduced,expression
R4823 T7497 T7494 prep of,expression
R4825 T7498 T7499 det these,proteins
R4826 T7499 T7497 pobj proteins,of
R4828 T7500 T7494 prep in,expression
R4829 T7501 T7502 amod whole,animal
R4830 T7502 T7504 compound animal,models
R4832 T7503 T7502 punct -,animal
R4833 T7504 T7500 pobj models,in
R4835 T7505 T7496 dobj phenotypes,generates
R4836 T7506 T7507 dep that,are
R4837 T7507 T7505 relcl are,phenotypes
R4838 T7508 T7509 npadvmod tissue,restricted
R4839 T7509 T7507 acomp restricted,are
R4840 T7510 T7509 punct -,restricted
R4842 T7511 T7507 cc and,are
R4843 T7512 T7513 advmod more,importantly
R4844 T7513 T7514 advmod importantly,seem
R4845 T7514 T7507 conj seem,are
R4847 T7515 T7514 punct ", ",seem
R4848 T7516 T7514 aux do,seem
R4849 T7517 T7514 neg not,seem
R4851 T7518 T7519 aux to,recapitulate
R4852 T7519 T7514 xcomp recapitulate,seem
R4854 T7520 T7519 dobj phenotypes,recapitulate
R4855 T7521 T7520 acl observed,phenotypes
R4856 T7522 T7521 prep with,observed
R4857 T7523 T7524 compound knockdown,experiments
R4859 T7524 T7522 pobj experiments,with
R4860 T7525 T7524 prep in,experiments
R4861 T7526 T7527 npadvmod cell,based
R4864 T7527 T7529 amod based,assays
R4865 T7528 T7527 punct -,based
R4866 T7529 T7525 pobj assays,in
R4868 T7530 T7529 compound culture,assays
R4869 T7531 T7496 punct .,generates
R4871 T7533 T7534 prep For,shown
R4873 T7535 T7533 pobj example,For
R4874 T7536 T7534 punct ", ",shown
R4875 T7537 T7538 amod short,knockdown
R4878 T7538 T7534 nsubj knockdown,shown
R4880 T7539 T7538 amod interfering,knockdown
R4881 T7540 T7541 npadvmod RNA,mediated
R4883 T7541 T7538 amod mediated,knockdown
R4884 T7542 T7541 punct -,mediated
R4885 T7543 T7538 prep of,knockdown
R4887 T7544 T7543 pobj RanBP2,of
R4888 T7545 T7546 punct [,9
R4889 T7546 T7538 parataxis 9,knockdown
R4890 T7547 T7546 punct ],9
R4891 T7548 T7538 cc and,knockdown
R4893 T7549 T7538 conj members,knockdown
R4894 T7550 T7549 prep of,members
R4895 T7551 T7552 det the,complex
R4897 T7552 T7550 pobj complex,of
R4898 T7553 T7554 compound Nup107,Nup160
R4899 T7554 T7552 compound Nup160,complex
R4901 T7555 T7554 punct -,Nup160
R4902 T7556 T7557 punct [,59
R4903 T7557 T7549 parataxis 59,members
R4905 T7558 T7559 punct –,61
R4906 T7559 T7557 prep 61,59
R4907 T7560 T7557 punct ],59
R4909 T7561 T7534 aux have,shown
R4910 T7562 T7534 punct ", ",shown
R4911 T7563 T7534 advmod respectively,shown
R4913 T7564 T7534 punct ", ",shown
R4914 T7565 T7566 aux to,cause
R4915 T7566 T7534 xcomp cause,shown
R4917 T7567 T7568 amod mitotic,arrest
R4918 T7568 T7566 dobj arrest,cause
R4920 T7569 T7568 cc and,arrest
R4921 T7570 T7568 conj disruption,arrest
R4922 T7571 T7570 prep of,disruption
R4924 T7572 T7573 amod nuclear,pore
R4925 T7573 T7574 compound pore,assembly
R4929 T7574 T7571 pobj assembly,of
R4930 T7575 T7570 cc and,disruption
R4932 T7576 T7570 conj deficits,disruption
R4933 T7577 T7576 prep in,deficits
R4935 T7578 T7579 compound mRNA,export
R4936 T7579 T7577 pobj export,in
R4937 T7580 T7566 prep in,cause
R4939 T7581 T7582 compound cell,culture
R4940 T7582 T7580 pobj culture,in
R4941 T7583 T7534 punct .,shown
R4942 T7585 T7586 advmod Yet,produce
R4944 T7587 T7586 punct ", ",produce
R4945 T7588 T7586 nsubj haploinsufficiency,produce
R4947 T7589 T7588 prep of,haploinsufficiency
R4948 T7590 T7589 pobj RanBP2,of
R4949 T7591 T7592 punct (,work
R4951 T7592 T7590 parataxis work,RanBP2
R4952 T7593 T7592 det this,work
R4953 T7594 T7592 punct ),work
R4955 T7595 T7590 cc and,RanBP2
R4956 T7596 T7590 conj Nup96,RanBP2
R4957 T7597 T7598 punct [,58
R4959 T7598 T7596 parataxis 58,Nup96
R4960 T7599 T7598 punct ],58
R4961 T7600 T7586 advmod predominantly,produce
R4963 T7601 T7586 punct ", ",produce
R4964 T7602 T7586 advmod instead,produce
R4965 T7603 T7586 punct ", ",produce
R4967 T7604 T7605 npadvmod CNS,restricted
R4968 T7605 T7607 amod restricted,deficits
R4969 T7606 T7605 punct -,restricted
R4971 T7607 T7586 dobj deficits,produce
R4972 T7608 T7607 prep in,deficits
R4973 T7609 T7610 compound energy,metabolism
R4975 T7610 T7608 pobj metabolism,in
R4976 T7611 T7607 cc and,deficits
R4978 T7612 T7607 conj alterations,deficits
R4980 T7613 T7612 prep in,alterations
R4981 T7614 T7615 det the,system
R4983 T7615 T7613 pobj system,in
R4984 T7616 T7615 amod immune,system
R4985 T7617 T7612 acl linked,alterations
R4987 T7618 T7617 prep to,linked
R4988 T7619 T7620 det the,regulation
R4990 T7620 T7618 pobj regulation,to
R4991 T7621 T7620 amod down,regulation
R4992 T7622 T7620 punct -,regulation
R4993 T7623 T7620 prep of,regulation
R4994 T7624 T7625 compound interferon,β
R4995 T7625 T7627 npadvmod β,regulated
R4996 T7680 T7670 dobj stage,set
R4997 T7626 T7625 punct -,β
R4998 T7627 T7629 amod regulated,proteins
R4999 T7628 T7627 punct -,regulated
R5000 T7629 T7623 pobj proteins,of
R5001 T7630 T7620 cc and,regulation
R5002 T7681 T7682 aux to,probe
R5003 T7631 T7632 amod increased,susceptibility
R5004 T7632 T7620 conj susceptibility,regulation
R5005 T7633 T7632 prep of,susceptibility
R5006 T7682 T7670 advcl probe,set
R5007 T7634 T7635 amod viral,infection
R5008 T7635 T7633 pobj infection,of
R5009 T7636 T7617 punct ", ",linked
R5010 T7683 T7684 amod novel,pathways
R5011 T7637 T7617 advmod respectively,linked
R5012 T7638 T7586 punct .,produce
R5013 T7684 T7682 dobj pathways,probe
R5014 T7640 T7641 mark While,remain
R5015 T7641 T7649 advcl remain,result
R5016 T7685 T7684 amod molecular,pathways
R5017 T7642 T7643 det these,disparities
R5018 T7643 T7641 nsubj disparities,remain
R5019 T7644 T7643 amod apparent,disparities
R5020 T7686 T7682 prep in,probe
R5021 T7645 T7643 compound outcome,disparities
R5022 T7646 T7643 prep among,disparities
R5023 T7647 T7648 amod experimental,systems
R5024 T7687 T7688 amod various,contexts
R5025 T7648 T7646 pobj systems,among
R5026 T7650 T7641 acomp unclear,remain
R5027 T7688 T7686 pobj contexts,in
R5028 T7651 T7649 punct ", ",result
R5029 T7652 T7649 nsubj they,result
R5030 T7653 T7649 aux could,result
R5031 T7689 T7688 amod physiological,contexts
R5032 T7654 T7649 advmod potentially,result
R5033 T7655 T7649 prep from,result
R5034 T7656 T7655 pobj variations,from
R5035 T7690 T7689 cc and,physiological
R5036 T7657 T7656 prep in,variations
R5037 T7658 T7657 pobj redundancies,in
R5038 T7691 T7689 conj genetic,physiological
R5039 T7659 T7658 cc and,redundancies
R5040 T7660 T7661 amod compensatory,mechanisms
R5041 T7661 T7658 conj mechanisms,redundancies
R5042 T7662 T7658 amod inherent,redundancies
R5043 T7692 T7682 punct ", ",probe
R5044 T7663 T7662 prep to,inherent
R5045 T7664 T7665 det each,system
R5046 T7665 T7663 pobj system,to
R5047 T7666 T7665 amod experimental,system
R5048 T7667 T7649 punct .,result
R5049 T7693 T7682 cc and,probe
R5050 T7669 T7670 advmod Regardless,set
R5051 T7694 T7682 conj provide,probe
R5052 T7671 T7670 punct ", ",set
R5053 T7672 T7673 det these,models
R5054 T7673 T7670 nsubj models,set
R5055 T7695 T7694 advmod also,provide
R5056 T7674 T7673 amod genetic,models
R5057 T7675 T7674 cc and,genetic
R5058 T7676 T7677 amod whole,animal
R5059 T7696 T7697 det a,link
R5060 T7677 T7674 conj animal,genetic
R5061 T7678 T7677 punct -,animal
R5062 T7679 T7680 det the,stage
R5063 T7697 T7694 dobj link,provide
R5064 T7698 T7697 prep to,link
R5065 T7699 T7700 amod pathophysiological,processes
R5066 T7700 T7698 pobj processes,to
R5067 T7701 T7700 acl underlying,processes
R5068 T7702 T7703 amod several,diseases
R5069 T7703 T7701 dobj diseases,underlying
R5070 T7704 T7703 amod human,diseases
R5071 T7705 T7670 punct .,set