Id |
Subject |
Object |
Predicate |
Lexical cue |
T14525 |
0-5 |
NN |
denotes |
Model |
T14526 |
6-15 |
VBG |
denotes |
Depicting |
T14527 |
16-17 |
DT |
denotes |
a |
T14528 |
18-22 |
NN |
denotes |
Role |
T14529 |
23-25 |
IN |
denotes |
of |
T14530 |
26-32 |
NN |
denotes |
RanBP2 |
T14531 |
33-36 |
CC |
denotes |
and |
T14532 |
37-41 |
DT |
denotes |
Some |
T14533 |
42-44 |
IN |
denotes |
of |
T14534 |
45-48 |
PRP$ |
denotes |
Its |
T14535 |
49-57 |
NNS |
denotes |
Partners |
T14536 |
58-60 |
IN |
denotes |
in |
T14537 |
61-70 |
JJ |
denotes |
Metabolic |
T14539 |
71-74 |
CC |
denotes |
and |
T14540 |
75-83 |
JJ |
denotes |
Neuronal |
T14538 |
84-92 |
NN |
denotes |
Function |
T14541 |
92-199 |
sentence |
denotes |
RanBP2 interacts with Cox11 and HKI and the triad is in equilibrium under normal physiological conditions. |
T14542 |
93-99 |
NN |
denotes |
RanBP2 |
T14543 |
100-109 |
VBZ |
denotes |
interacts |
T14544 |
110-114 |
IN |
denotes |
with |
T14545 |
115-120 |
NN |
denotes |
Cox11 |
T14546 |
121-124 |
CC |
denotes |
and |
T14547 |
125-128 |
NN |
denotes |
HKI |
T14548 |
129-132 |
CC |
denotes |
and |
T14549 |
133-136 |
DT |
denotes |
the |
T14550 |
137-142 |
NN |
denotes |
triad |
T14551 |
143-145 |
VBZ |
denotes |
is |
T14552 |
146-148 |
IN |
denotes |
in |
T14553 |
149-160 |
NN |
denotes |
equilibrium |
T14554 |
161-166 |
IN |
denotes |
under |
T14555 |
167-173 |
JJ |
denotes |
normal |
T14557 |
174-187 |
JJ |
denotes |
physiological |
T14556 |
188-198 |
NNS |
denotes |
conditions |
T14558 |
198-199 |
. |
denotes |
. |
T14559 |
199-267 |
sentence |
denotes |
RanBP2 prevents the inhibition of HKI by Cox11 and its degradation. |
T14560 |
200-206 |
NN |
denotes |
RanBP2 |
T14561 |
207-215 |
VBZ |
denotes |
prevents |
T14562 |
216-219 |
DT |
denotes |
the |
T14563 |
220-230 |
NN |
denotes |
inhibition |
T14564 |
231-233 |
IN |
denotes |
of |
T14565 |
234-237 |
NN |
denotes |
HKI |
T14566 |
238-240 |
IN |
denotes |
by |
T14567 |
241-246 |
NN |
denotes |
Cox11 |
T14568 |
247-250 |
CC |
denotes |
and |
T14569 |
251-254 |
PRP$ |
denotes |
its |
T14570 |
255-266 |
NN |
denotes |
degradation |
T14571 |
266-267 |
. |
denotes |
. |
T14572 |
267-381 |
sentence |
denotes |
The ultimate effect of RanBP2 on its partners is the stimulation of the glycolytic pathway and production of ATP. |
T14573 |
268-271 |
DT |
denotes |
The |
T14575 |
272-280 |
JJ |
denotes |
ultimate |
T14574 |
281-287 |
NN |
denotes |
effect |
T14577 |
288-290 |
IN |
denotes |
of |
T14578 |
291-297 |
NN |
denotes |
RanBP2 |
T14579 |
298-300 |
IN |
denotes |
on |
T14580 |
301-304 |
PRP$ |
denotes |
its |
T14581 |
305-313 |
NNS |
denotes |
partners |
T14576 |
314-316 |
VBZ |
denotes |
is |
T14582 |
317-320 |
DT |
denotes |
the |
T14583 |
321-332 |
NN |
denotes |
stimulation |
T14584 |
333-335 |
IN |
denotes |
of |
T14585 |
336-339 |
DT |
denotes |
the |
T14587 |
340-350 |
JJ |
denotes |
glycolytic |
T14586 |
351-358 |
NN |
denotes |
pathway |
T14588 |
359-362 |
CC |
denotes |
and |
T14589 |
363-373 |
NN |
denotes |
production |
T14590 |
374-376 |
IN |
denotes |
of |
T14591 |
377-380 |
NN |
denotes |
ATP |
T14592 |
380-381 |
. |
denotes |
. |
T14593 |
381-563 |
sentence |
denotes |
The glycolytic pathway is critical to fuel the constitutive Na+/K+-ATPase pump to maintain the dark current between the inner and outer segment compartments of photosensory neurons. |
T14594 |
382-385 |
DT |
denotes |
The |
T14596 |
386-396 |
JJ |
denotes |
glycolytic |
T14595 |
397-404 |
NN |
denotes |
pathway |
T14597 |
405-407 |
VBZ |
denotes |
is |
T14598 |
408-416 |
JJ |
denotes |
critical |
T14599 |
417-419 |
TO |
denotes |
to |
T14600 |
420-424 |
VB |
denotes |
fuel |
T14601 |
425-428 |
DT |
denotes |
the |
T14603 |
429-441 |
JJ |
denotes |
constitutive |
T14604 |
442-445 |
NN |
denotes |
Na+ |
T14606 |
445-446 |
SYM |
denotes |
/ |
T14605 |
446-448 |
NN |
denotes |
K+ |
T14608 |
448-449 |
HYPH |
denotes |
- |
T14607 |
449-455 |
NN |
denotes |
ATPase |
T14602 |
456-460 |
NN |
denotes |
pump |
T14609 |
461-463 |
TO |
denotes |
to |
T14610 |
464-472 |
VB |
denotes |
maintain |
T14611 |
473-476 |
DT |
denotes |
the |
T14613 |
477-481 |
JJ |
denotes |
dark |
T14612 |
482-489 |
NN |
denotes |
current |
T14614 |
490-497 |
IN |
denotes |
between |
T14615 |
498-501 |
DT |
denotes |
the |
T14617 |
502-507 |
JJ |
denotes |
inner |
T14618 |
508-511 |
CC |
denotes |
and |
T14619 |
512-517 |
JJ |
denotes |
outer |
T14620 |
518-525 |
NN |
denotes |
segment |
T14616 |
526-538 |
NNS |
denotes |
compartments |
T14621 |
539-541 |
IN |
denotes |
of |
T14622 |
542-554 |
JJ |
denotes |
photosensory |
T14623 |
555-562 |
NNS |
denotes |
neurons |
T14624 |
562-563 |
. |
denotes |
. |
T14625 |
563-661 |
sentence |
denotes |
A deficit (haploinsufficiency) in RanBP2 disturbs the equilibrium between RanBP2, HKI, and Cox11. |
T14626 |
564-565 |
DT |
denotes |
A |
T14627 |
566-573 |
NN |
denotes |
deficit |
T14629 |
574-575 |
-LRB- |
denotes |
( |
T14630 |
575-593 |
NN |
denotes |
haploinsufficiency |
T14631 |
593-594 |
-RRB- |
denotes |
) |
T14632 |
595-597 |
IN |
denotes |
in |
T14633 |
598-604 |
NN |
denotes |
RanBP2 |
T14628 |
605-613 |
VBZ |
denotes |
disturbs |
T14634 |
614-617 |
DT |
denotes |
the |
T14635 |
618-629 |
NN |
denotes |
equilibrium |
T14636 |
630-637 |
IN |
denotes |
between |
T14637 |
638-644 |
NN |
denotes |
RanBP2 |
T14638 |
644-646 |
, |
denotes |
, |
T14639 |
646-649 |
NN |
denotes |
HKI |
T14640 |
649-651 |
, |
denotes |
, |
T14641 |
651-654 |
CC |
denotes |
and |
T14642 |
655-660 |
NN |
denotes |
Cox11 |
T14643 |
660-661 |
. |
denotes |
. |
T14644 |
661-913 |
sentence |
denotes |
This pathophysiological event promotes the destabilization and degradation of HKI and a decrease in ATP production required to maintain the depolarization state neurons, and, hence, a reduction in the response of receptoral and postreceptoral neurons. |
T14645 |
662-666 |
DT |
denotes |
This |
T14647 |
667-685 |
JJ |
denotes |
pathophysiological |
T14646 |
686-691 |
NN |
denotes |
event |
T14648 |
692-700 |
VBZ |
denotes |
promotes |
T14649 |
701-704 |
DT |
denotes |
the |
T14650 |
705-720 |
NN |
denotes |
destabilization |
T14651 |
721-724 |
CC |
denotes |
and |
T14652 |
725-736 |
NN |
denotes |
degradation |
T14653 |
737-739 |
IN |
denotes |
of |
T14654 |
740-743 |
NN |
denotes |
HKI |
T14655 |
744-747 |
CC |
denotes |
and |
T14656 |
748-749 |
DT |
denotes |
a |
T14657 |
750-758 |
NN |
denotes |
decrease |
T14658 |
759-761 |
IN |
denotes |
in |
T14659 |
762-765 |
NN |
denotes |
ATP |
T14660 |
766-776 |
NN |
denotes |
production |
T14661 |
777-785 |
VBN |
denotes |
required |
T14662 |
786-788 |
TO |
denotes |
to |
T14663 |
789-797 |
VB |
denotes |
maintain |
T14664 |
798-801 |
DT |
denotes |
the |
T14666 |
802-816 |
NN |
denotes |
depolarization |
T14667 |
817-822 |
NN |
denotes |
state |
T14665 |
823-830 |
NNS |
denotes |
neurons |
T14668 |
830-832 |
, |
denotes |
, |
T14669 |
832-835 |
CC |
denotes |
and |
T14670 |
835-837 |
, |
denotes |
, |
T14671 |
837-842 |
RB |
denotes |
hence |
T14673 |
842-844 |
, |
denotes |
, |
T14674 |
844-845 |
DT |
denotes |
a |
T14672 |
846-855 |
NN |
denotes |
reduction |
T14675 |
856-858 |
IN |
denotes |
in |
T14676 |
859-862 |
DT |
denotes |
the |
T14677 |
863-871 |
NN |
denotes |
response |
T14678 |
872-874 |
IN |
denotes |
of |
T14679 |
875-885 |
JJ |
denotes |
receptoral |
T14681 |
886-889 |
CC |
denotes |
and |
T14682 |
890-904 |
JJ |
denotes |
postreceptoral |
T14680 |
905-912 |
NNS |
denotes |
neurons |
T14683 |
912-913 |
. |
denotes |
. |
T14684 |
913-985 |
sentence |
denotes |
A reduction in ATP levels also negatively modulates HKI activity/level. |
T14685 |
914-915 |
DT |
denotes |
A |
T14686 |
916-925 |
NN |
denotes |
reduction |
T14688 |
926-928 |
IN |
denotes |
in |
T14689 |
929-932 |
NN |
denotes |
ATP |
T14690 |
933-939 |
NNS |
denotes |
levels |
T14691 |
940-944 |
RB |
denotes |
also |
T14692 |
945-955 |
RB |
denotes |
negatively |
T14687 |
956-965 |
VBZ |
denotes |
modulates |
T14693 |
966-969 |
NN |
denotes |
HKI |
T14694 |
970-978 |
NN |
denotes |
activity |
T14695 |
978-979 |
SYM |
denotes |
/ |
T14696 |
979-984 |
NN |
denotes |
level |
T14697 |
984-985 |
. |
denotes |
. |
T14698 |
985-1143 |
sentence |
denotes |
Decreased levels of HKI promote intracellular hyperglycemia and activate stress kinases, which modulate negatively the Na+/K+-ATPase pump by phosphorylation. |
T14699 |
986-995 |
VBN |
denotes |
Decreased |
T14700 |
996-1002 |
NNS |
denotes |
levels |
T14702 |
1003-1005 |
IN |
denotes |
of |
T14703 |
1006-1009 |
NN |
denotes |
HKI |
T14701 |
1010-1017 |
VBP |
denotes |
promote |
T14704 |
1018-1031 |
JJ |
denotes |
intracellular |
T14705 |
1032-1045 |
NN |
denotes |
hyperglycemia |
T14706 |
1046-1049 |
CC |
denotes |
and |
T14707 |
1050-1058 |
VBP |
denotes |
activate |
T14708 |
1059-1065 |
NN |
denotes |
stress |
T14709 |
1066-1073 |
NNS |
denotes |
kinases |
T14710 |
1073-1075 |
, |
denotes |
, |
T14711 |
1075-1080 |
WDT |
denotes |
which |
T14712 |
1081-1089 |
VBP |
denotes |
modulate |
T14713 |
1090-1100 |
RB |
denotes |
negatively |
T14714 |
1101-1104 |
DT |
denotes |
the |
T14716 |
1105-1108 |
NN |
denotes |
Na+ |
T14718 |
1108-1109 |
HYPH |
denotes |
/ |
T14717 |
1109-1111 |
NN |
denotes |
K+ |
T14720 |
1111-1112 |
HYPH |
denotes |
- |
T14719 |
1112-1118 |
NN |
denotes |
ATPase |
T14715 |
1119-1123 |
NN |
denotes |
pump |
T14721 |
1124-1126 |
IN |
denotes |
by |
T14722 |
1127-1142 |
NN |
denotes |
phosphorylation |
T14723 |
1142-1143 |
. |
denotes |
. |
T14724 |
1143-1240 |
sentence |
denotes |
Pathophysiological pathways promoted by RanBP2 haploinsufficiency are represented by dash lines. |
T14725 |
1144-1162 |
JJ |
denotes |
Pathophysiological |
T14726 |
1163-1171 |
NNS |
denotes |
pathways |
T14728 |
1172-1180 |
VBN |
denotes |
promoted |
T14729 |
1181-1183 |
IN |
denotes |
by |
T14730 |
1184-1190 |
NN |
denotes |
RanBP2 |
T14731 |
1191-1209 |
NN |
denotes |
haploinsufficiency |
T14732 |
1210-1213 |
VBP |
denotes |
are |
T14727 |
1214-1225 |
VBN |
denotes |
represented |
T14733 |
1226-1228 |
IN |
denotes |
by |
T14734 |
1229-1233 |
NN |
denotes |
dash |
T14735 |
1234-1239 |
NNS |
denotes |
lines |
T14736 |
1239-1240 |
. |
denotes |
. |
T14737 |
1240-1288 |
sentence |
denotes |
RIS, rod inner segment; ROS, rod outer segment. |
T14738 |
1241-1244 |
NN |
denotes |
RIS |
T14739 |
1244-1246 |
, |
denotes |
, |
T14740 |
1246-1249 |
NN |
denotes |
rod |
T14742 |
1250-1255 |
JJ |
denotes |
inner |
T14741 |
1256-1263 |
NN |
denotes |
segment |
T14743 |
1263-1264 |
: |
denotes |
; |
T14744 |
1265-1268 |
NN |
denotes |
ROS |
T14745 |
1268-1270 |
, |
denotes |
, |
T14746 |
1270-1273 |
NN |
denotes |
rod |
T14748 |
1274-1279 |
JJ |
denotes |
outer |
T14747 |
1280-1287 |
NN |
denotes |
segment |
T14749 |
1287-1288 |
. |
denotes |
. |
R9536 |
T14526 |
T14525 |
acl |
Depicting,Model |
R9537 |
T14527 |
T14528 |
det |
a,Role |
R9538 |
T14528 |
T14526 |
dobj |
Role,Depicting |
R9539 |
T14529 |
T14528 |
prep |
of,Role |
R9540 |
T14530 |
T14529 |
pobj |
RanBP2,of |
R9541 |
T14531 |
T14530 |
cc |
and,RanBP2 |
R9542 |
T14532 |
T14530 |
conj |
Some,RanBP2 |
R9543 |
T14533 |
T14532 |
prep |
of,Some |
R9544 |
T14534 |
T14535 |
poss |
Its,Partners |
R9545 |
T14535 |
T14533 |
pobj |
Partners,of |
R9546 |
T14536 |
T14528 |
prep |
in,Role |
R9547 |
T14537 |
T14538 |
amod |
Metabolic,Function |
R9548 |
T14538 |
T14536 |
pobj |
Function,in |
R9549 |
T14539 |
T14537 |
cc |
and,Metabolic |
R9550 |
T14540 |
T14537 |
conj |
Neuronal,Metabolic |
R9551 |
T14542 |
T14543 |
nsubj |
RanBP2,interacts |
R9552 |
T14544 |
T14543 |
prep |
with,interacts |
R9553 |
T14545 |
T14544 |
pobj |
Cox11,with |
R9554 |
T14546 |
T14545 |
cc |
and,Cox11 |
R9555 |
T14547 |
T14545 |
conj |
HKI,Cox11 |
R9556 |
T14548 |
T14543 |
cc |
and,interacts |
R9557 |
T14549 |
T14550 |
det |
the,triad |
R9558 |
T14550 |
T14551 |
nsubj |
triad,is |
R9559 |
T14551 |
T14543 |
conj |
is,interacts |
R9560 |
T14552 |
T14551 |
prep |
in,is |
R9561 |
T14553 |
T14552 |
pobj |
equilibrium,in |
R9562 |
T14554 |
T14551 |
prep |
under,is |
R9563 |
T14555 |
T14556 |
amod |
normal,conditions |
R9564 |
T14556 |
T14554 |
pobj |
conditions,under |
R9565 |
T14557 |
T14556 |
amod |
physiological,conditions |
R9566 |
T14558 |
T14551 |
punct |
.,is |
R9567 |
T14560 |
T14561 |
nsubj |
RanBP2,prevents |
R9568 |
T14562 |
T14563 |
det |
the,inhibition |
R9569 |
T14563 |
T14561 |
dobj |
inhibition,prevents |
R9570 |
T14564 |
T14563 |
prep |
of,inhibition |
R9571 |
T14565 |
T14564 |
pobj |
HKI,of |
R9572 |
T14566 |
T14563 |
prep |
by,inhibition |
R9573 |
T14567 |
T14566 |
pobj |
Cox11,by |
R9574 |
T14568 |
T14567 |
cc |
and,Cox11 |
R9575 |
T14569 |
T14570 |
poss |
its,degradation |
R9576 |
T14570 |
T14567 |
conj |
degradation,Cox11 |
R9577 |
T14571 |
T14561 |
punct |
.,prevents |
R9578 |
T14573 |
T14574 |
det |
The,effect |
R9579 |
T14574 |
T14576 |
nsubj |
effect,is |
R9580 |
T14575 |
T14574 |
amod |
ultimate,effect |
R9581 |
T14577 |
T14574 |
prep |
of,effect |
R9582 |
T14578 |
T14577 |
pobj |
RanBP2,of |
R9583 |
T14579 |
T14574 |
prep |
on,effect |
R9584 |
T14580 |
T14581 |
poss |
its,partners |
R9585 |
T14581 |
T14579 |
pobj |
partners,on |
R9586 |
T14582 |
T14583 |
det |
the,stimulation |
R9587 |
T14583 |
T14576 |
attr |
stimulation,is |
R9588 |
T14584 |
T14583 |
prep |
of,stimulation |
R9589 |
T14585 |
T14586 |
det |
the,pathway |
R9590 |
T14586 |
T14584 |
pobj |
pathway,of |
R9591 |
T14587 |
T14586 |
amod |
glycolytic,pathway |
R9592 |
T14588 |
T14583 |
cc |
and,stimulation |
R9593 |
T14589 |
T14583 |
conj |
production,stimulation |
R9594 |
T14590 |
T14589 |
prep |
of,production |
R9595 |
T14591 |
T14590 |
pobj |
ATP,of |
R9596 |
T14592 |
T14576 |
punct |
.,is |
R9597 |
T14594 |
T14595 |
det |
The,pathway |
R9598 |
T14595 |
T14597 |
nsubj |
pathway,is |
R9599 |
T14596 |
T14595 |
amod |
glycolytic,pathway |
R9600 |
T14598 |
T14597 |
acomp |
critical,is |
R9601 |
T14599 |
T14600 |
aux |
to,fuel |
R9602 |
T14600 |
T14597 |
advcl |
fuel,is |
R9603 |
T14601 |
T14602 |
det |
the,pump |
R9604 |
T14602 |
T14600 |
dobj |
pump,fuel |
R9605 |
T14603 |
T14602 |
amod |
constitutive,pump |
R9606 |
T14604 |
T14605 |
nmod |
Na+,K+ |
R9607 |
T14605 |
T14607 |
compound |
K+,ATPase |
R9608 |
T14606 |
T14605 |
punct |
/,K+ |
R9609 |
T14607 |
T14602 |
compound |
ATPase,pump |
R9610 |
T14608 |
T14607 |
punct |
-,ATPase |
R9611 |
T14609 |
T14610 |
aux |
to,maintain |
R9612 |
T14610 |
T14600 |
advcl |
maintain,fuel |
R9613 |
T14611 |
T14612 |
det |
the,current |
R9614 |
T14612 |
T14610 |
dobj |
current,maintain |
R9615 |
T14613 |
T14612 |
amod |
dark,current |
R9616 |
T14614 |
T14612 |
prep |
between,current |
R9617 |
T14615 |
T14616 |
det |
the,compartments |
R9618 |
T14616 |
T14614 |
pobj |
compartments,between |
R9619 |
T14617 |
T14616 |
amod |
inner,compartments |
R9620 |
T14618 |
T14617 |
cc |
and,inner |
R9621 |
T14619 |
T14617 |
conj |
outer,inner |
R9622 |
T14620 |
T14616 |
compound |
segment,compartments |
R9623 |
T14621 |
T14616 |
prep |
of,compartments |
R9624 |
T14622 |
T14623 |
amod |
photosensory,neurons |
R9625 |
T14623 |
T14621 |
pobj |
neurons,of |
R9626 |
T14624 |
T14597 |
punct |
.,is |
R9627 |
T14626 |
T14627 |
det |
A,deficit |
R9628 |
T14627 |
T14628 |
nsubj |
deficit,disturbs |
R9629 |
T14629 |
T14627 |
punct |
(,deficit |
R9630 |
T14630 |
T14627 |
appos |
haploinsufficiency,deficit |
R9631 |
T14631 |
T14627 |
punct |
),deficit |
R9632 |
T14632 |
T14627 |
prep |
in,deficit |
R9633 |
T14633 |
T14632 |
pobj |
RanBP2,in |
R9634 |
T14634 |
T14635 |
det |
the,equilibrium |
R9635 |
T14635 |
T14628 |
dobj |
equilibrium,disturbs |
R9636 |
T14636 |
T14635 |
prep |
between,equilibrium |
R9637 |
T14637 |
T14636 |
pobj |
RanBP2,between |
R9638 |
T14638 |
T14637 |
punct |
", ",RanBP2 |
R9639 |
T14639 |
T14637 |
conj |
HKI,RanBP2 |
R9640 |
T14640 |
T14639 |
punct |
", ",HKI |
R9641 |
T14641 |
T14639 |
cc |
and,HKI |
R9642 |
T14642 |
T14639 |
conj |
Cox11,HKI |
R9643 |
T14643 |
T14628 |
punct |
.,disturbs |
R9644 |
T14645 |
T14646 |
det |
This,event |
R9645 |
T14646 |
T14648 |
nsubj |
event,promotes |
R9646 |
T14647 |
T14646 |
amod |
pathophysiological,event |
R9647 |
T14649 |
T14650 |
det |
the,destabilization |
R9648 |
T14650 |
T14648 |
dobj |
destabilization,promotes |
R9649 |
T14651 |
T14650 |
cc |
and,destabilization |
R9650 |
T14652 |
T14650 |
conj |
degradation,destabilization |
R9651 |
T14653 |
T14650 |
prep |
of,destabilization |
R9652 |
T14654 |
T14653 |
pobj |
HKI,of |
R9653 |
T14655 |
T14650 |
cc |
and,destabilization |
R9654 |
T14656 |
T14657 |
det |
a,decrease |
R9655 |
T14657 |
T14650 |
conj |
decrease,destabilization |
R9656 |
T14658 |
T14657 |
prep |
in,decrease |
R9657 |
T14659 |
T14660 |
compound |
ATP,production |
R9658 |
T14660 |
T14658 |
pobj |
production,in |
R9659 |
T14661 |
T14660 |
acl |
required,production |
R9660 |
T14662 |
T14663 |
aux |
to,maintain |
R9661 |
T14663 |
T14661 |
advcl |
maintain,required |
R9662 |
T14664 |
T14665 |
det |
the,neurons |
R9663 |
T14665 |
T14663 |
dobj |
neurons,maintain |
R9664 |
T14666 |
T14665 |
compound |
depolarization,neurons |
R9665 |
T14667 |
T14665 |
compound |
state,neurons |
R9666 |
T14668 |
T14657 |
punct |
", ",decrease |
R9667 |
T14669 |
T14657 |
cc |
and,decrease |
R9668 |
T14670 |
T14657 |
punct |
", ",decrease |
R9669 |
T14671 |
T14672 |
advmod |
hence,reduction |
R9670 |
T14672 |
T14657 |
conj |
reduction,decrease |
R9671 |
T14673 |
T14672 |
punct |
", ",reduction |
R9672 |
T14674 |
T14672 |
det |
a,reduction |
R9673 |
T14675 |
T14672 |
prep |
in,reduction |
R9674 |
T14676 |
T14677 |
det |
the,response |
R9675 |
T14677 |
T14675 |
pobj |
response,in |
R9676 |
T14678 |
T14677 |
prep |
of,response |
R9677 |
T14679 |
T14680 |
amod |
receptoral,neurons |
R9678 |
T14680 |
T14678 |
pobj |
neurons,of |
R9679 |
T14681 |
T14679 |
cc |
and,receptoral |
R9680 |
T14682 |
T14679 |
conj |
postreceptoral,receptoral |
R9681 |
T14683 |
T14648 |
punct |
.,promotes |
R9682 |
T14685 |
T14686 |
det |
A,reduction |
R9683 |
T14686 |
T14687 |
nsubj |
reduction,modulates |
R9684 |
T14688 |
T14686 |
prep |
in,reduction |
R9685 |
T14689 |
T14690 |
compound |
ATP,levels |
R9686 |
T14690 |
T14688 |
pobj |
levels,in |
R9687 |
T14691 |
T14687 |
advmod |
also,modulates |
R9688 |
T14692 |
T14687 |
advmod |
negatively,modulates |
R9689 |
T14693 |
T14694 |
compound |
HKI,activity |
R9690 |
T14694 |
T14687 |
dobj |
activity,modulates |
R9691 |
T14695 |
T14696 |
punct |
/,level |
R9692 |
T14696 |
T14694 |
prep |
level,activity |
R9693 |
T14697 |
T14687 |
punct |
.,modulates |
R9694 |
T14699 |
T14700 |
amod |
Decreased,levels |
R9695 |
T14700 |
T14701 |
nsubj |
levels,promote |
R9696 |
T14702 |
T14700 |
prep |
of,levels |
R9697 |
T14703 |
T14702 |
pobj |
HKI,of |
R9698 |
T14704 |
T14705 |
amod |
intracellular,hyperglycemia |
R9699 |
T14705 |
T14701 |
dobj |
hyperglycemia,promote |
R9700 |
T14706 |
T14701 |
cc |
and,promote |
R9701 |
T14707 |
T14701 |
conj |
activate,promote |
R9702 |
T14708 |
T14709 |
compound |
stress,kinases |
R9703 |
T14709 |
T14707 |
dobj |
kinases,activate |
R9704 |
T14710 |
T14709 |
punct |
", ",kinases |
R9705 |
T14711 |
T14712 |
dep |
which,modulate |
R9706 |
T14712 |
T14709 |
relcl |
modulate,kinases |
R9707 |
T14713 |
T14712 |
advmod |
negatively,modulate |
R9708 |
T14714 |
T14715 |
det |
the,pump |
R9709 |
T14715 |
T14712 |
dobj |
pump,modulate |
R9710 |
T14716 |
T14717 |
compound |
Na+,K+ |
R9711 |
T14717 |
T14719 |
compound |
K+,ATPase |
R9712 |
T14718 |
T14717 |
punct |
/,K+ |
R9713 |
T14719 |
T14715 |
compound |
ATPase,pump |
R9714 |
T14720 |
T14719 |
punct |
-,ATPase |
R9715 |
T14721 |
T14712 |
prep |
by,modulate |
R9716 |
T14722 |
T14721 |
pobj |
phosphorylation,by |
R9717 |
T14723 |
T14701 |
punct |
.,promote |
R9718 |
T14725 |
T14726 |
amod |
Pathophysiological,pathways |
R9719 |
T14726 |
T14727 |
nsubjpass |
pathways,represented |
R9720 |
T14728 |
T14726 |
acl |
promoted,pathways |
R9721 |
T14729 |
T14728 |
agent |
by,promoted |
R9722 |
T14730 |
T14731 |
compound |
RanBP2,haploinsufficiency |
R9723 |
T14731 |
T14729 |
pobj |
haploinsufficiency,by |
R9724 |
T14732 |
T14727 |
auxpass |
are,represented |
R9725 |
T14733 |
T14727 |
agent |
by,represented |
R9726 |
T14734 |
T14735 |
compound |
dash,lines |
R9727 |
T14735 |
T14733 |
pobj |
lines,by |
R9728 |
T14736 |
T14727 |
punct |
.,represented |
R9729 |
T14739 |
T14738 |
punct |
", ",RIS |
R9730 |
T14740 |
T14741 |
nmod |
rod,segment |
R9731 |
T14741 |
T14738 |
appos |
segment,RIS |
R9732 |
T14742 |
T14741 |
amod |
inner,segment |
R9733 |
T14743 |
T14738 |
punct |
;,RIS |
R9734 |
T14744 |
T14738 |
appos |
ROS,RIS |
R9735 |
T14745 |
T14744 |
punct |
", ",ROS |
R9736 |
T14746 |
T14747 |
nmod |
rod,segment |
R9737 |
T14747 |
T14744 |
appos |
segment,ROS |
R9738 |
T14748 |
T14747 |
amod |
outer,segment |
R9739 |
T14749 |
T14738 |
punct |
.,RIS |