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PMC:1626108 / 36046-38434 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7012 0-3 DT denotes The
T7013 4-8 NNS denotes data
T7015 9-15 RB denotes herein
T7014 16-20 VBP denotes show
T7016 21-28 NNS denotes tissues
T7017 29-33 IN denotes with
T7018 34-35 DT denotes a
T7019 36-44 NN denotes decrease
T7020 45-47 IN denotes of
T7021 48-54 NN denotes RanBP2
T7022 55-58 CC denotes and
T7023 59-62 NN denotes HKI
T7024 63-69 NNS denotes levels
T7025 70-76 VBP denotes mirror
T7026 77-78 DT denotes a
T7027 79-88 NN denotes reduction
T7028 89-91 IN denotes in
T7029 92-95 DT denotes the
T7031 96-99 NN denotes ATP
T7030 100-106 NNS denotes levels
T7032 106-107 . denotes .
T7033 107-458 sentence denotes Since the constitutive Na+/K+ ATPase pump and the ATP-dependent conversion of glutamine to glutamate (both fundamental to maintain the electrical activity in the CNS) consumes the vast majority of the energy produced by the CNS [45–47], this likely underlies the suppression of the electrophysiological output responses of retinal neurons (Figure 8).
T7034 108-113 IN denotes Since
T7036 114-117 DT denotes the
T7038 118-130 JJ denotes constitutive
T7039 131-134 NN denotes Na+
T7041 134-135 HYPH denotes /
T7040 135-137 NN denotes K+
T7042 138-144 NN denotes ATPase
T7037 145-149 NN denotes pump
T7043 150-153 CC denotes and
T7044 154-157 DT denotes the
T7046 158-161 NN denotes ATP
T7048 161-162 HYPH denotes -
T7047 162-171 JJ denotes dependent
T7045 172-182 NN denotes conversion
T7049 183-185 IN denotes of
T7050 186-195 NN denotes glutamine
T7051 196-198 IN denotes to
T7052 199-208 NN denotes glutamate
T7053 209-210 -LRB- denotes (
T7054 210-214 DT denotes both
T7055 215-226 JJ denotes fundamental
T7056 227-229 TO denotes to
T7057 230-238 VB denotes maintain
T7058 239-242 DT denotes the
T7060 243-253 JJ denotes electrical
T7059 254-262 NN denotes activity
T7061 263-265 IN denotes in
T7062 266-269 DT denotes the
T7063 270-273 NN denotes CNS
T7064 273-274 -RRB- denotes )
T7035 275-283 VBZ denotes consumes
T7066 284-287 DT denotes the
T7068 288-292 JJ denotes vast
T7067 293-301 NN denotes majority
T7069 302-304 IN denotes of
T7070 305-308 DT denotes the
T7071 309-315 NN denotes energy
T7072 316-324 VBN denotes produced
T7073 325-327 IN denotes by
T7074 328-331 DT denotes the
T7075 332-335 NN denotes CNS
T7076 336-337 -LRB- denotes [
T7077 337-339 CD denotes 45
T7078 339-340 SYM denotes –
T7079 340-342 CD denotes 47
T7080 342-343 -RRB- denotes ]
T7081 343-345 , denotes ,
T7082 345-349 DT denotes this
T7083 350-356 RB denotes likely
T7065 357-366 VBZ denotes underlies
T7084 367-370 DT denotes the
T7085 371-382 NN denotes suppression
T7086 383-385 IN denotes of
T7087 386-389 DT denotes the
T7089 390-410 JJ denotes electrophysiological
T7090 411-417 NN denotes output
T7088 418-427 NNS denotes responses
T7091 428-430 IN denotes of
T7092 431-438 JJ denotes retinal
T7093 439-446 NNS denotes neurons
T7094 447-448 -LRB- denotes (
T7095 448-454 NN denotes Figure
T7096 455-456 CD denotes 8
T7097 456-457 -RRB- denotes )
T7098 457-458 . denotes .
T7099 458-651 sentence denotes Moreover, deficits in HKI may lead to intracellular hyperglycemia in the CNS, promote sorbitol-induced osmotic stress, and compromise further the ATPase-dependent Na+/K+ pump activity [48–50].
T7100 459-467 RB denotes Moreover
T7102 467-469 , denotes ,
T7103 469-477 NNS denotes deficits
T7104 478-480 IN denotes in
T7105 481-484 NN denotes HKI
T7106 485-488 MD denotes may
T7101 489-493 VB denotes lead
T7107 494-496 IN denotes to
T7108 497-510 JJ denotes intracellular
T7109 511-524 NN denotes hyperglycemia
T7110 525-527 IN denotes in
T7111 528-531 DT denotes the
T7112 532-535 NN denotes CNS
T7113 535-537 , denotes ,
T7114 537-544 VB denotes promote
T7115 545-553 NN denotes sorbitol
T7117 553-554 HYPH denotes -
T7116 554-561 VBN denotes induced
T7119 562-569 JJ denotes osmotic
T7118 570-576 NN denotes stress
T7120 576-578 , denotes ,
T7121 578-581 CC denotes and
T7122 582-592 VB denotes compromise
T7123 593-600 RB denotes further
T7124 601-604 DT denotes the
T7126 605-611 NN denotes ATPase
T7128 611-612 HYPH denotes -
T7127 612-621 JJ denotes dependent
T7129 622-625 NN denotes Na+
T7131 625-626 HYPH denotes /
T7130 626-628 NN denotes K+
T7132 629-633 NN denotes pump
T7125 634-642 NN denotes activity
T7133 643-644 -LRB- denotes [
T7134 644-646 CD denotes 48
T7135 646-647 SYM denotes –
T7136 647-649 CD denotes 50
T7137 649-650 -RRB- denotes ]
T7138 650-651 . denotes .
T7139 651-755 sentence denotes This may be exacerbated by a decrease of ATP, since the activity of HKI is also stimulated by ATP [51].
T7140 652-656 DT denotes This
T7142 657-660 MD denotes may
T7143 661-663 VB denotes be
T7141 664-675 VBN denotes exacerbated
T7144 676-678 IN denotes by
T7145 679-680 DT denotes a
T7146 681-689 NN denotes decrease
T7147 690-692 IN denotes of
T7148 693-696 NN denotes ATP
T7149 696-698 , denotes ,
T7150 698-703 IN denotes since
T7152 704-707 DT denotes the
T7153 708-716 NN denotes activity
T7154 717-719 IN denotes of
T7155 720-723 NN denotes HKI
T7156 724-726 VBZ denotes is
T7157 727-731 RB denotes also
T7151 732-742 VBN denotes stimulated
T7158 743-745 IN denotes by
T7159 746-749 NN denotes ATP
T7160 750-751 -LRB- denotes [
T7161 751-753 CD denotes 51
T7162 753-754 -RRB- denotes ]
T7163 754-755 . denotes .
T7164 755-936 sentence denotes The cumulative effects of a reduction in ATP and intracellular hyperglycemia are known to act synergistically and modulate the electrophysiological properties of neuronal activity.
T7165 756-759 DT denotes The
T7167 760-770 JJ denotes cumulative
T7166 771-778 NNS denotes effects
T7169 779-781 IN denotes of
T7170 782-783 DT denotes a
T7171 784-793 NN denotes reduction
T7172 794-796 IN denotes in
T7173 797-800 NN denotes ATP
T7174 801-804 CC denotes and
T7175 805-818 JJ denotes intracellular
T7176 819-832 NN denotes hyperglycemia
T7177 833-836 VBP denotes are
T7168 837-842 VBN denotes known
T7178 843-845 TO denotes to
T7179 846-849 VB denotes act
T7180 850-865 RB denotes synergistically
T7181 866-869 CC denotes and
T7182 870-878 VB denotes modulate
T7183 879-882 DT denotes the
T7185 883-903 JJ denotes electrophysiological
T7184 904-914 NNS denotes properties
T7186 915-917 IN denotes of
T7187 918-926 JJ denotes neuronal
T7188 927-935 NN denotes activity
T7189 935-936 . denotes .
T7190 936-1030 sentence denotes Figure 9 integrates in a model these variables and implications of the data presented herein.
T7191 937-943 NN denotes Figure
T7193 944-945 CD denotes 9
T7192 946-956 VBZ denotes integrates
T7194 957-959 IN denotes in
T7195 960-961 DT denotes a
T7196 962-967 NN denotes model
T7197 968-973 DT denotes these
T7198 974-983 NNS denotes variables
T7199 984-987 CC denotes and
T7200 988-1000 NNS denotes implications
T7201 1001-1003 IN denotes of
T7202 1004-1007 DT denotes the
T7203 1008-1012 NNS denotes data
T7204 1013-1022 VBN denotes presented
T7205 1023-1029 RB denotes herein
T7206 1029-1030 . denotes .
T7207 1030-1193 sentence denotes Still, other bona fide RanBP2 partners previously identified and described in the Introduction also become strong candidates to play a role in energy homeostasis.
T7208 1031-1036 RB denotes Still
T7210 1036-1038 , denotes ,
T7211 1038-1043 JJ denotes other
T7213 1044-1048 FW denotes bona
T7214 1049-1053 FW denotes fide
T7215 1054-1060 NN denotes RanBP2
T7212 1061-1069 NNS denotes partners
T7216 1070-1080 RB denotes previously
T7217 1081-1091 VBN denotes identified
T7218 1092-1095 CC denotes and
T7219 1096-1105 VBN denotes described
T7220 1106-1108 IN denotes in
T7221 1109-1112 DT denotes the
T7222 1113-1125 NN denotes Introduction
T7223 1126-1130 RB denotes also
T7209 1131-1137 VBP denotes become
T7224 1138-1144 JJ denotes strong
T7225 1145-1155 NNS denotes candidates
T7226 1156-1158 TO denotes to
T7227 1159-1163 VB denotes play
T7228 1164-1165 DT denotes a
T7229 1166-1170 NN denotes role
T7230 1171-1173 IN denotes in
T7231 1174-1180 NN denotes energy
T7232 1181-1192 NN denotes homeostasis
T7233 1192-1193 . denotes .
T7234 1193-1634 sentence denotes For example, the unfolding and chaperone activity of components of the 19S cap of the proteasome may be modulated by the CLD of RanBP2 [14] and contribute to the selective HKI (and other substrates) degradation [43], while association of nuclear import receptor, importin-β with the Ran-binding domains of RanBP2 [10,11], may mediate the nuclear translocation of multifunctional substrates, such as glyceraldehyde-3-phosphate dehydrogenase.
T7235 1194-1197 IN denotes For
T7237 1198-1205 NN denotes example
T7238 1205-1207 , denotes ,
T7239 1207-1210 DT denotes the
T7241 1211-1220 JJ denotes unfolding
T7243 1221-1224 CC denotes and
T7242 1225-1234 NN denotes chaperone
T7240 1235-1243 NN denotes activity
T7244 1244-1246 IN denotes of
T7245 1247-1257 NNS denotes components
T7246 1258-1260 IN denotes of
T7247 1261-1264 DT denotes the
T7249 1265-1268 NN denotes 19S
T7248 1269-1272 NN denotes cap
T7250 1273-1275 IN denotes of
T7251 1276-1279 DT denotes the
T7252 1280-1290 NN denotes proteasome
T7253 1291-1294 MD denotes may
T7254 1295-1297 VB denotes be
T7236 1298-1307 VBN denotes modulated
T7255 1308-1310 IN denotes by
T7256 1311-1314 DT denotes the
T7257 1315-1318 NN denotes CLD
T7258 1319-1321 IN denotes of
T7259 1322-1328 NN denotes RanBP2
T7260 1329-1330 -LRB- denotes [
T7261 1330-1332 CD denotes 14
T7262 1332-1333 -RRB- denotes ]
T7263 1334-1337 CC denotes and
T7264 1338-1348 VB denotes contribute
T7265 1349-1351 IN denotes to
T7266 1352-1355 DT denotes the
T7268 1356-1365 JJ denotes selective
T7269 1366-1369 NN denotes HKI
T7270 1370-1371 -LRB- denotes (
T7271 1371-1374 CC denotes and
T7272 1375-1380 JJ denotes other
T7273 1381-1391 NNS denotes substrates
T7274 1391-1392 -RRB- denotes )
T7267 1393-1404 NN denotes degradation
T7275 1405-1406 -LRB- denotes [
T7276 1406-1408 CD denotes 43
T7277 1408-1409 -RRB- denotes ]
T7278 1409-1411 , denotes ,
T7279 1411-1416 IN denotes while
T7281 1417-1428 NN denotes association
T7282 1429-1431 IN denotes of
T7283 1432-1439 JJ denotes nuclear
T7285 1440-1446 NN denotes import
T7284 1447-1455 NN denotes receptor
T7286 1455-1457 , denotes ,
T7287 1457-1465 NN denotes importin
T7289 1465-1466 HYPH denotes -
T7288 1466-1467 NN denotes β
T7290 1468-1472 IN denotes with
T7291 1473-1476 DT denotes the
T7293 1477-1480 NN denotes Ran
T7295 1480-1481 HYPH denotes -
T7294 1481-1488 VBG denotes binding
T7292 1489-1496 NNS denotes domains
T7296 1497-1499 IN denotes of
T7297 1500-1506 NN denotes RanBP2
T7298 1507-1508 -LRB- denotes [
T7300 1508-1510 CD denotes 10
T7301 1510-1511 , denotes ,
T7299 1511-1513 CD denotes 11
T7302 1513-1514 -RRB- denotes ]
T7303 1514-1516 , denotes ,
T7304 1516-1519 MD denotes may
T7280 1520-1527 VB denotes mediate
T7305 1528-1531 DT denotes the
T7307 1532-1539 JJ denotes nuclear
T7306 1540-1553 NN denotes translocation
T7308 1554-1556 IN denotes of
T7309 1557-1572 JJ denotes multifunctional
T7310 1573-1583 NNS denotes substrates
T7311 1583-1585 , denotes ,
T7312 1585-1589 JJ denotes such
T7313 1590-1592 IN denotes as
T7314 1593-1607 NN denotes glyceraldehyde
T7316 1607-1608 HYPH denotes -
T7317 1608-1609 CD denotes 3
T7318 1609-1610 HYPH denotes -
T7315 1610-1619 NN denotes phosphate
T7319 1620-1633 NN denotes dehydrogenase
T7320 1633-1634 . denotes .
T7321 1634-1810 sentence denotes This trafficking process is selectively inhibited by the neuroprotective drug, R-(-)-deprenyl and derivates thereof, and are often employed to treat Parkinson disease [52–57].
T7322 1635-1639 DT denotes This
T7324 1640-1651 NN denotes trafficking
T7323 1652-1659 NN denotes process
T7326 1660-1662 VBZ denotes is
T7327 1663-1674 RB denotes selectively
T7325 1675-1684 VBN denotes inhibited
T7328 1685-1687 IN denotes by
T7329 1688-1691 DT denotes the
T7331 1692-1707 JJ denotes neuroprotective
T7330 1708-1712 NN denotes drug
T7332 1712-1714 , denotes ,
T7333 1714-1715 NN denotes R
T7335 1715-1716 HYPH denotes -
T7336 1716-1717 -LRB- denotes (
T7337 1717-1718 SYM denotes -
T7338 1718-1719 -RRB- denotes )
T7339 1719-1720 HYPH denotes -
T7334 1720-1728 NN denotes deprenyl
T7340 1729-1732 CC denotes and
T7341 1733-1742 VBZ denotes derivates
T7342 1743-1750 RB denotes thereof
T7343 1750-1752 , denotes ,
T7344 1752-1755 CC denotes and
T7345 1756-1759 VBP denotes are
T7347 1760-1765 RB denotes often
T7346 1766-1774 VBN denotes employed
T7348 1775-1777 TO denotes to
T7349 1778-1783 VB denotes treat
T7350 1784-1793 NNP denotes Parkinson
T7351 1794-1801 NN denotes disease
T7352 1802-1803 -LRB- denotes [
T7353 1803-1805 CD denotes 52
T7354 1805-1806 SYM denotes –
T7355 1806-1808 CD denotes 57
T7356 1808-1809 -RRB- denotes ]
T7357 1809-1810 . denotes .
T7358 1810-2154 sentence denotes Hence, RanBP2 and its partners emerge as key players and target genes in mediating neuropathophysiological mechanisms implicated in various genetic and environmental lesions to the CNS, as in patients with Parkinson, diabetes with insulin-resistance, and other neuropathies and neurodegenerative diseases, often linked to aging manifestations.
T7359 1811-1816 RB denotes Hence
T7361 1816-1818 , denotes ,
T7362 1818-1824 NN denotes RanBP2
T7363 1825-1828 CC denotes and
T7364 1829-1832 PRP$ denotes its
T7365 1833-1841 NNS denotes partners
T7360 1842-1848 VBP denotes emerge
T7366 1849-1851 IN denotes as
T7367 1852-1855 JJ denotes key
T7368 1856-1863 NNS denotes players
T7369 1864-1867 CC denotes and
T7370 1868-1874 NN denotes target
T7371 1875-1880 NNS denotes genes
T7372 1881-1883 IN denotes in
T7373 1884-1893 VBG denotes mediating
T7374 1894-1917 JJ denotes neuropathophysiological
T7375 1918-1928 NNS denotes mechanisms
T7376 1929-1939 VBN denotes implicated
T7377 1940-1942 IN denotes in
T7378 1943-1950 JJ denotes various
T7380 1951-1958 JJ denotes genetic
T7381 1959-1962 CC denotes and
T7382 1963-1976 JJ denotes environmental
T7379 1977-1984 NNS denotes lesions
T7383 1985-1987 IN denotes to
T7384 1988-1991 DT denotes the
T7385 1992-1995 NN denotes CNS
T7386 1995-1997 , denotes ,
T7387 1997-1999 IN denotes as
T7388 2000-2002 IN denotes in
T7389 2003-2011 NNS denotes patients
T7390 2012-2016 IN denotes with
T7391 2017-2026 NNP denotes Parkinson
T7392 2026-2028 , denotes ,
T7393 2028-2036 NN denotes diabetes
T7394 2037-2041 IN denotes with
T7395 2042-2049 NN denotes insulin
T7397 2049-2050 HYPH denotes -
T7396 2050-2060 NN denotes resistance
T7398 2060-2062 , denotes ,
T7399 2062-2065 CC denotes and
T7400 2066-2071 JJ denotes other
T7401 2072-2084 NNS denotes neuropathies
T7402 2085-2088 CC denotes and
T7403 2089-2106 JJ denotes neurodegenerative
T7404 2107-2115 NNS denotes diseases
T7405 2115-2117 , denotes ,
T7406 2117-2122 RB denotes often
T7407 2123-2129 VBN denotes linked
T7408 2130-2132 IN denotes to
T7409 2133-2138 NN denotes aging
T7410 2139-2153 NNS denotes manifestations
T7411 2153-2154 . denotes .
T7412 2154-2388 sentence denotes To this effect, the RanBP2 mouse model will serve as a unique genetic tool to probe selective, multiple and novel pathways, which may have not been anticipated to be linked to metabolic processes and allied pathophysiological states.
T7413 2155-2157 IN denotes To
T7415 2158-2162 DT denotes this
T7416 2163-2169 NN denotes effect
T7417 2169-2171 , denotes ,
T7418 2171-2174 DT denotes the
T7420 2175-2181 NN denotes RanBP2
T7421 2182-2187 NN denotes mouse
T7419 2188-2193 NN denotes model
T7422 2194-2198 MD denotes will
T7414 2199-2204 VB denotes serve
T7423 2205-2207 IN denotes as
T7424 2208-2209 DT denotes a
T7426 2210-2216 JJ denotes unique
T7427 2217-2224 JJ denotes genetic
T7425 2225-2229 NN denotes tool
T7428 2230-2232 TO denotes to
T7429 2233-2238 VB denotes probe
T7430 2239-2248 JJ denotes selective
T7432 2248-2250 , denotes ,
T7433 2250-2258 JJ denotes multiple
T7434 2259-2262 CC denotes and
T7435 2263-2268 JJ denotes novel
T7431 2269-2277 NNS denotes pathways
T7436 2277-2279 , denotes ,
T7437 2279-2284 WDT denotes which
T7439 2285-2288 MD denotes may
T7440 2289-2293 VB denotes have
T7441 2294-2297 RB denotes not
T7442 2298-2302 VBN denotes been
T7438 2303-2314 VBN denotes anticipated
T7443 2315-2317 TO denotes to
T7445 2318-2320 VB denotes be
T7444 2321-2327 VBN denotes linked
T7446 2328-2330 IN denotes to
T7447 2331-2340 JJ denotes metabolic
T7448 2341-2350 NNS denotes processes
T7449 2351-2354 CC denotes and
T7450 2355-2361 VBN denotes allied
T7452 2362-2380 JJ denotes pathophysiological
T7451 2381-2387 NNS denotes states
T7453 2387-2388 . denotes .
R4411 T7012 T7013 det The,data
R4412 T7013 T7014 nsubj data,show
R4413 T7015 T7013 advmod herein,data
R4414 T7016 T7014 dobj tissues,show
R4415 T7017 T7016 prep with,tissues
R4416 T7018 T7019 det a,decrease
R4417 T7019 T7017 pobj decrease,with
R4418 T7020 T7019 prep of,decrease
R4419 T7021 T7020 pobj RanBP2,of
R4420 T7022 T7014 cc and,show
R4421 T7023 T7024 compound HKI,levels
R4422 T7024 T7025 nsubj levels,mirror
R4423 T7025 T7014 conj mirror,show
R4424 T7026 T7027 det a,reduction
R4425 T7027 T7025 dobj reduction,mirror
R4426 T7028 T7027 prep in,reduction
R4427 T7029 T7030 det the,levels
R4428 T7030 T7028 pobj levels,in
R4429 T7031 T7030 compound ATP,levels
R4430 T7032 T7025 punct .,mirror
R4431 T7034 T7035 mark Since,consumes
R4432 T7035 T7065 advcl consumes,underlies
R4433 T7036 T7037 det the,pump
R4434 T7037 T7035 nsubj pump,consumes
R4435 T7038 T7037 amod constitutive,pump
R4436 T7039 T7040 compound Na+,K+
R4437 T7040 T7037 compound K+,pump
R4438 T7041 T7040 punct /,K+
R4439 T7042 T7037 compound ATPase,pump
R4440 T7043 T7037 cc and,pump
R4441 T7044 T7045 det the,conversion
R4442 T7045 T7037 conj conversion,pump
R4443 T7046 T7047 npadvmod ATP,dependent
R4444 T7047 T7045 amod dependent,conversion
R4445 T7048 T7047 punct -,dependent
R4446 T7049 T7045 prep of,conversion
R4447 T7050 T7049 pobj glutamine,of
R4448 T7051 T7045 prep to,conversion
R4449 T7052 T7051 pobj glutamate,to
R4450 T7053 T7035 punct (,consumes
R4451 T7054 T7055 nsubj both,fundamental
R4452 T7055 T7035 advcl fundamental,consumes
R4453 T7056 T7057 aux to,maintain
R4454 T7057 T7055 advcl maintain,fundamental
R4455 T7058 T7059 det the,activity
R4456 T7059 T7057 dobj activity,maintain
R4457 T7060 T7059 amod electrical,activity
R4458 T7061 T7057 prep in,maintain
R4459 T7062 T7063 det the,CNS
R4460 T7063 T7061 pobj CNS,in
R4461 T7064 T7035 punct ),consumes
R4462 T7066 T7067 det the,majority
R4463 T7067 T7035 dobj majority,consumes
R4464 T7068 T7067 amod vast,majority
R4465 T7069 T7067 prep of,majority
R4466 T7070 T7071 det the,energy
R4467 T7071 T7069 pobj energy,of
R4468 T7072 T7071 acl produced,energy
R4469 T7073 T7072 agent by,produced
R4470 T7074 T7075 det the,CNS
R4471 T7075 T7073 pobj CNS,by
R4472 T7076 T7077 punct [,45
R4473 T7077 T7035 parataxis 45,consumes
R4474 T7078 T7079 punct –,47
R4475 T7079 T7077 prep 47,45
R4476 T7080 T7077 punct ],45
R4477 T7081 T7065 punct ", ",underlies
R4478 T7082 T7065 nsubj this,underlies
R4479 T7083 T7065 advmod likely,underlies
R4480 T7084 T7085 det the,suppression
R4481 T7085 T7065 dobj suppression,underlies
R4482 T7086 T7085 prep of,suppression
R4483 T7087 T7088 det the,responses
R4484 T7088 T7086 pobj responses,of
R4485 T7089 T7090 amod electrophysiological,output
R4486 T7090 T7088 compound output,responses
R4487 T7091 T7088 prep of,responses
R4488 T7092 T7093 amod retinal,neurons
R4489 T7093 T7091 pobj neurons,of
R4490 T7094 T7095 punct (,Figure
R4491 T7095 T7065 parataxis Figure,underlies
R4492 T7096 T7095 nummod 8,Figure
R4493 T7097 T7095 punct ),Figure
R4494 T7098 T7065 punct .,underlies
R4495 T7100 T7101 advmod Moreover,lead
R4496 T7102 T7101 punct ", ",lead
R4497 T7103 T7101 nsubj deficits,lead
R4498 T7104 T7103 prep in,deficits
R4499 T7105 T7104 pobj HKI,in
R4500 T7106 T7101 aux may,lead
R4501 T7107 T7101 prep to,lead
R4502 T7108 T7109 amod intracellular,hyperglycemia
R4503 T7109 T7107 pobj hyperglycemia,to
R4504 T7110 T7101 prep in,lead
R4505 T7111 T7112 det the,CNS
R4506 T7112 T7110 pobj CNS,in
R4507 T7113 T7101 punct ", ",lead
R4508 T7114 T7101 conj promote,lead
R4509 T7115 T7116 npadvmod sorbitol,induced
R4510 T7116 T7118 amod induced,stress
R4511 T7117 T7116 punct -,induced
R4512 T7118 T7114 dobj stress,promote
R4513 T7119 T7118 amod osmotic,stress
R4514 T7120 T7114 punct ", ",promote
R4515 T7121 T7114 cc and,promote
R4516 T7122 T7114 conj compromise,promote
R4517 T7123 T7122 advmod further,compromise
R4518 T7124 T7125 det the,activity
R4519 T7125 T7122 dobj activity,compromise
R4520 T7126 T7127 npadvmod ATPase,dependent
R4521 T7127 T7125 amod dependent,activity
R4522 T7128 T7127 punct -,dependent
R4523 T7129 T7130 compound Na+,K+
R4524 T7130 T7125 compound K+,activity
R4525 T7131 T7130 punct /,K+
R4526 T7132 T7125 compound pump,activity
R4527 T7133 T7134 punct [,48
R4528 T7134 T7122 parataxis 48,compromise
R4529 T7135 T7136 punct –,50
R4530 T7136 T7134 prep 50,48
R4531 T7137 T7134 punct ],48
R4532 T7138 T7101 punct .,lead
R4533 T7140 T7141 nsubjpass This,exacerbated
R4534 T7142 T7141 aux may,exacerbated
R4535 T7143 T7141 auxpass be,exacerbated
R4536 T7144 T7141 agent by,exacerbated
R4537 T7145 T7146 det a,decrease
R4538 T7146 T7144 pobj decrease,by
R4539 T7147 T7146 prep of,decrease
R4540 T7148 T7147 pobj ATP,of
R4541 T7149 T7141 punct ", ",exacerbated
R4542 T7150 T7151 mark since,stimulated
R4543 T7151 T7141 advcl stimulated,exacerbated
R4544 T7152 T7153 det the,activity
R4545 T7153 T7151 nsubjpass activity,stimulated
R4546 T7154 T7153 prep of,activity
R4547 T7155 T7154 pobj HKI,of
R4548 T7156 T7151 auxpass is,stimulated
R4549 T7157 T7151 advmod also,stimulated
R4550 T7158 T7151 agent by,stimulated
R4551 T7159 T7158 pobj ATP,by
R4552 T7160 T7161 punct [,51
R4553 T7161 T7151 parataxis 51,stimulated
R4554 T7162 T7161 punct ],51
R4555 T7163 T7141 punct .,exacerbated
R4556 T7165 T7166 det The,effects
R4557 T7166 T7168 nsubjpass effects,known
R4558 T7167 T7166 amod cumulative,effects
R4559 T7169 T7166 prep of,effects
R4560 T7170 T7171 det a,reduction
R4561 T7171 T7169 pobj reduction,of
R4562 T7172 T7171 prep in,reduction
R4563 T7173 T7172 pobj ATP,in
R4564 T7174 T7171 cc and,reduction
R4565 T7175 T7176 amod intracellular,hyperglycemia
R4566 T7176 T7171 conj hyperglycemia,reduction
R4567 T7177 T7168 auxpass are,known
R4568 T7178 T7179 aux to,act
R4569 T7179 T7168 xcomp act,known
R4570 T7180 T7179 advmod synergistically,act
R4571 T7181 T7179 cc and,act
R4572 T7182 T7179 conj modulate,act
R4573 T7183 T7184 det the,properties
R4574 T7184 T7182 dobj properties,modulate
R4575 T7185 T7184 amod electrophysiological,properties
R4576 T7186 T7184 prep of,properties
R4577 T7187 T7188 amod neuronal,activity
R4578 T7188 T7186 pobj activity,of
R4579 T7189 T7168 punct .,known
R4580 T7191 T7192 nsubj Figure,integrates
R4581 T7193 T7191 nummod 9,Figure
R4582 T7194 T7192 prep in,integrates
R4583 T7195 T7196 det a,model
R4584 T7196 T7194 pobj model,in
R4585 T7197 T7198 det these,variables
R4586 T7198 T7192 dobj variables,integrates
R4587 T7199 T7198 cc and,variables
R4588 T7200 T7198 conj implications,variables
R4589 T7201 T7200 prep of,implications
R4590 T7202 T7203 det the,data
R4591 T7203 T7201 pobj data,of
R4592 T7204 T7203 acl presented,data
R4593 T7205 T7204 advmod herein,presented
R4594 T7206 T7192 punct .,integrates
R4595 T7208 T7209 advmod Still,become
R4596 T7210 T7209 punct ", ",become
R4597 T7211 T7212 amod other,partners
R4598 T7212 T7209 nsubj partners,become
R4599 T7213 T7214 advmod bona,fide
R4600 T7214 T7212 amod fide,partners
R4601 T7215 T7212 compound RanBP2,partners
R4602 T7216 T7217 advmod previously,identified
R4603 T7217 T7212 acl identified,partners
R4604 T7218 T7217 cc and,identified
R4605 T7219 T7217 conj described,identified
R4606 T7220 T7219 prep in,described
R4607 T7221 T7222 det the,Introduction
R4608 T7222 T7220 pobj Introduction,in
R4609 T7223 T7209 advmod also,become
R4610 T7224 T7225 amod strong,candidates
R4611 T7225 T7209 attr candidates,become
R4612 T7226 T7227 aux to,play
R4613 T7227 T7225 advcl play,candidates
R4614 T7228 T7229 det a,role
R4615 T7229 T7227 dobj role,play
R4616 T7230 T7227 prep in,play
R4617 T7231 T7232 compound energy,homeostasis
R4618 T7232 T7230 pobj homeostasis,in
R4619 T7233 T7209 punct .,become
R4620 T7235 T7236 prep For,modulated
R4621 T7274 T7267 punct ),degradation
R4622 T7237 T7235 pobj example,For
R4623 T7275 T7276 punct [,43
R4624 T7276 T7264 parataxis 43,contribute
R4625 T7238 T7236 punct ", ",modulated
R4626 T7277 T7276 punct ],43
R4627 T7278 T7236 punct ", ",modulated
R4628 T7239 T7240 det the,activity
R4629 T7279 T7280 mark while,mediate
R4630 T7280 T7236 advcl mediate,modulated
R4631 T7281 T7280 nsubj association,mediate
R4632 T7282 T7281 prep of,association
R4633 T7283 T7284 amod nuclear,receptor
R4634 T7284 T7282 pobj receptor,of
R4635 T7240 T7236 nsubjpass activity,modulated
R4636 T7285 T7284 compound import,receptor
R4637 T7286 T7284 punct ", ",receptor
R4638 T7287 T7288 compound importin,β
R4639 T7241 T7242 amod unfolding,chaperone
R4640 T7288 T7284 appos β,receptor
R4641 T7289 T7288 punct -,β
R4642 T7290 T7281 prep with,association
R4643 T7242 T7240 compound chaperone,activity
R4644 T7291 T7292 det the,domains
R4645 T7292 T7290 pobj domains,with
R4646 T7293 T7294 npadvmod Ran,binding
R4647 T7243 T7242 cc and,chaperone
R4648 T7294 T7292 amod binding,domains
R4649 T7295 T7294 punct -,binding
R4650 T7244 T7240 prep of,activity
R4651 T7296 T7292 prep of,domains
R4652 T7297 T7296 pobj RanBP2,of
R4653 T7298 T7299 punct [,11
R4654 T7245 T7244 pobj components,of
R4655 T7299 T7281 parataxis 11,association
R4656 T7300 T7299 nummod 10,11
R4657 T7301 T7299 punct ",",11
R4658 T7246 T7245 prep of,components
R4659 T7302 T7299 punct ],11
R4660 T7303 T7280 punct ", ",mediate
R4661 T7247 T7248 det the,cap
R4662 T7304 T7280 aux may,mediate
R4663 T7305 T7306 det the,translocation
R4664 T7306 T7280 dobj translocation,mediate
R4665 T7307 T7306 amod nuclear,translocation
R4666 T7248 T7246 pobj cap,of
R4667 T7308 T7306 prep of,translocation
R4668 T7309 T7310 amod multifunctional,substrates
R4669 T7249 T7248 compound 19S,cap
R4670 T7310 T7308 pobj substrates,of
R4671 T7311 T7310 punct ", ",substrates
R4672 T7312 T7313 amod such,as
R4673 T7250 T7248 prep of,cap
R4674 T7313 T7310 prep as,substrates
R4675 T7314 T7315 nmod glyceraldehyde,phosphate
R4676 T7251 T7252 det the,proteasome
R4677 T7315 T7319 compound phosphate,dehydrogenase
R4678 T7252 T7250 pobj proteasome,of
R4679 T7316 T7315 punct -,phosphate
R4680 T7317 T7315 nummod 3,phosphate
R4681 T7318 T7315 punct -,phosphate
R4682 T7319 T7313 pobj dehydrogenase,as
R4683 T7320 T7236 punct .,modulated
R4684 T7253 T7236 aux may,modulated
R4685 T7322 T7323 det This,process
R4686 T7323 T7325 nsubjpass process,inhibited
R4687 T7254 T7236 auxpass be,modulated
R4688 T7324 T7323 compound trafficking,process
R4689 T7326 T7325 auxpass is,inhibited
R4690 T7255 T7236 agent by,modulated
R4691 T7327 T7325 advmod selectively,inhibited
R4692 T7328 T7325 agent by,inhibited
R4693 T7329 T7330 det the,drug
R4694 T7256 T7257 det the,CLD
R4695 T7330 T7328 pobj drug,by
R4696 T7331 T7330 amod neuroprotective,drug
R4697 T7332 T7330 punct ", ",drug
R4698 T7257 T7255 pobj CLD,by
R4699 T7333 T7334 nmod R,deprenyl
R4700 T7334 T7330 appos deprenyl,drug
R4701 T7258 T7257 prep of,CLD
R4702 T7335 T7333 punct -,R
R4703 T7336 T7333 punct (,R
R4704 T7337 T7333 punct -,R
R4705 T7259 T7258 pobj RanBP2,of
R4706 T7338 T7333 punct ),R
R4707 T7339 T7333 punct -,R
R4708 T7260 T7261 punct [,14
R4709 T7340 T7330 cc and,drug
R4710 T7341 T7330 conj derivates,drug
R4711 T7342 T7341 advmod thereof,derivates
R4712 T7261 T7236 parataxis 14,modulated
R4713 T7343 T7325 punct ", ",inhibited
R4714 T7344 T7325 cc and,inhibited
R4715 T7262 T7261 punct ],14
R4716 T7345 T7346 auxpass are,employed
R4717 T7346 T7325 conj employed,inhibited
R4718 T7347 T7346 advmod often,employed
R4719 T7263 T7236 cc and,modulated
R4720 T7348 T7349 aux to,treat
R4721 T7349 T7346 advcl treat,employed
R4722 T7350 T7351 compound Parkinson,disease
R4723 T7264 T7236 conj contribute,modulated
R4724 T7351 T7349 dobj disease,treat
R4725 T7352 T7353 punct [,52
R4726 T7353 T7346 parataxis 52,employed
R4727 T7265 T7264 prep to,contribute
R4728 T7354 T7355 punct –,57
R4729 T7355 T7353 prep 57,52
R4730 T7356 T7353 punct ],52
R4731 T7266 T7267 det the,degradation
R4732 T7357 T7325 punct .,inhibited
R4733 T7359 T7360 advmod Hence,emerge
R4734 T7361 T7360 punct ", ",emerge
R4735 T7267 T7265 pobj degradation,to
R4736 T7362 T7360 nsubj RanBP2,emerge
R4737 T7363 T7362 cc and,RanBP2
R4738 T7364 T7365 poss its,partners
R4739 T7268 T7267 amod selective,degradation
R4740 T7365 T7362 conj partners,RanBP2
R4741 T7366 T7360 prep as,emerge
R4742 T7367 T7368 amod key,players
R4743 T7269 T7267 nmod HKI,degradation
R4744 T7368 T7366 pobj players,as
R4745 T7270 T7269 punct (,HKI
R4746 T7271 T7269 cc and,HKI
R4747 T7369 T7368 cc and,players
R4748 T7370 T7371 compound target,genes
R4749 T7371 T7368 conj genes,players
R4750 T7272 T7273 amod other,substrates
R4751 T7372 T7360 prep in,emerge
R4752 T7373 T7372 pcomp mediating,in
R4753 T7374 T7375 amod neuropathophysiological,mechanisms
R4754 T7273 T7269 conj substrates,HKI
R4755 T7375 T7373 dobj mechanisms,mediating
R4756 T7376 T7375 acl implicated,mechanisms
R4757 T7377 T7376 prep in,implicated
R4758 T7379 T7377 pobj lesions,in
R4759 T7378 T7379 amod various,lesions
R4760 T7380 T7379 amod genetic,lesions
R4761 T7381 T7380 cc and,genetic
R4762 T7382 T7380 conj environmental,genetic
R4763 T7383 T7379 prep to,lesions
R4764 T7384 T7385 det the,CNS
R4765 T7385 T7383 pobj CNS,to
R4767 T7386 T7379 punct ", ",lesions
R4770 T7387 T7379 prep as,lesions
R4773 T7388 T7387 prep in,as
R4777 T7389 T7388 pobj patients,in
R4779 T7390 T7389 prep with,patients
R4783 T7391 T7390 pobj Parkinson,with
R4784 T7392 T7391 punct ", ",Parkinson
R4785 T7393 T7391 conj diabetes,Parkinson
R4789 T7394 T7393 prep with,diabetes
R4793 T7395 T7396 compound insulin,resistance
R4797 T7396 T7394 pobj resistance,with
R4800 T7397 T7396 punct -,resistance
R4804 T7398 T7393 punct ", ",diabetes
R4808 T7399 T7393 cc and,diabetes
R4812 T7400 T7401 amod other,neuropathies
R4816 T7401 T7393 conj neuropathies,diabetes
R4818 T7402 T7401 cc and,neuropathies
R4822 T7403 T7404 amod neurodegenerative,diseases
R4824 T7404 T7401 conj diseases,neuropathies
R4827 T7405 T7401 punct ", ",neuropathies
R4831 T7406 T7407 advmod often,linked
R4834 T7407 T7401 acl linked,neuropathies
R4841 T7408 T7407 prep to,linked
R4846 T7409 T7410 compound aging,manifestations
R4850 T7410 T7408 pobj manifestations,to
R4853 T7411 T7360 punct .,emerge
R4858 T7413 T7414 prep To,serve
R4862 T7415 T7416 det this,effect
R4863 T7416 T7413 pobj effect,To
R4867 T7417 T7414 punct ", ",serve
R4870 T7418 T7419 det the,model
R4872 T7419 T7414 nsubj model,serve
R4876 T7420 T7419 compound RanBP2,model
R4877 T7421 T7419 compound mouse,model
R4879 T7422 T7414 aux will,serve
R4882 T7423 T7414 prep as,serve
R4886 T7424 T7425 det a,tool
R4892 T7425 T7423 pobj tool,as
R4896 T7426 T7425 amod unique,tool
R4900 T7427 T7425 amod genetic,tool
R4904 T7428 T7429 aux to,probe
R4908 T7429 T7425 advcl probe,tool
R4912 T7430 T7431 amod selective,pathways
R4916 T7431 T7429 dobj pathways,probe
R4919 T7432 T7430 punct ", ",selective
R4923 T7433 T7430 conj multiple,selective
R4926 T7434 T7433 cc and,multiple
R4927 T7435 T7433 conj novel,multiple
R4928 T7436 T7431 punct ", ",pathways
R4931 T7437 T7438 dep which,anticipated
R4934 T7438 T7431 relcl anticipated,pathways
R4938 T7439 T7438 aux may,anticipated
R4943 T7440 T7438 aux have,anticipated
R4946 T7441 T7438 neg not,anticipated
R4950 T7442 T7438 auxpass been,anticipated
R4954 T7443 T7444 aux to,linked
R4958 T7444 T7438 xcomp linked,anticipated
R4962 T7445 T7444 auxpass be,linked
R4966 T7446 T7444 prep to,linked
R4970 T7447 T7448 amod metabolic,processes
R4974 T7448 T7446 pobj processes,to
R4977 T7449 T7448 cc and,processes
R4979 T7450 T7451 amod allied,states
R4982 T7451 T7448 conj states,processes
R4986 T7452 T7451 amod pathophysiological,states
R4989 T7453 T7414 punct .,serve