PMC:1626108 / 31397-41172 JSON TXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id	Subject	Object	Predicate	Lexical cue
T6106	11-14	PRP$	denotes	Our
T6107	15-23	NNS	denotes	findings
T6108	24-31	VBP	denotes	support
T6109	32-36	IN	denotes	that
T6111	37-43	NN	denotes	RanBP2
T6110	44-49	VBZ	denotes	plays
T6112	50-51	DT	denotes	a
T6114	52-63	JJ	denotes	determinant
T6113	64-68	NN	denotes	role
T6115	69-71	IN	denotes	in
T6116	72-82	VBG	denotes	modulating
T6117	83-90	NN	denotes	glucose
T6118	91-94	CC	denotes	and
T6119	95-101	NN	denotes	energy
T6120	102-113	NN	denotes	homeostasis
T6121	113-114	.	denotes	.
T6122	114-222	sentence	denotes	The data support that Cox1 and HKI are novel partners in vivo for the large LD of RanBP2 (Figures 1 and 2).
T6123	115-118	DT	denotes	The
T6124	119-123	NNS	denotes	data
T6125	124-131	VBP	denotes	support
T6126	132-136	IN	denotes	that
T6128	137-141	NN	denotes	Cox1
T6129	142-145	CC	denotes	and
T6130	146-149	NN	denotes	HKI
T6127	150-153	VBP	denotes	are
T6131	154-159	JJ	denotes	novel
T6132	160-168	NNS	denotes	partners
T6133	169-171	FW	denotes	in
T6134	172-176	FW	denotes	vivo
T6135	177-180	IN	denotes	for
T6136	181-184	DT	denotes	the
T6138	185-190	JJ	denotes	large
T6137	191-193	NN	denotes	LD
T6139	194-196	IN	denotes	of
T6140	197-203	NN	denotes	RanBP2
T6141	204-205	-LRB-	denotes	(
T6143	205-212	NNS	denotes	Figures
T6142	213-214	CD	denotes	1
T6144	215-218	CC	denotes	and
T6145	219-220	CD	denotes	2
T6146	220-221	-RRB-	denotes	)
T6147	221-222	.	denotes	.
T6148	222-347	sentence	denotes	The LD of RanBP2 exhibits chaperone activity toward folding intermediates of Cox11, and possibly, the mature HKI (Figure 1).
T6149	223-226	DT	denotes	The
T6150	227-229	NN	denotes	LD
T6152	230-232	IN	denotes	of
T6153	233-239	NN	denotes	RanBP2
T6151	240-248	VBZ	denotes	exhibits
T6154	249-258	NN	denotes	chaperone
T6155	259-267	NN	denotes	activity
T6156	268-274	IN	denotes	toward
T6157	275-282	NN	denotes	folding
T6158	283-296	NNS	denotes	intermediates
T6159	297-299	IN	denotes	of
T6160	300-305	NN	denotes	Cox11
T6161	305-307	,	denotes	,
T6162	307-310	CC	denotes	and
T6163	311-319	RB	denotes	possibly
T6165	319-321	,	denotes	,
T6166	321-324	DT	denotes	the
T6167	325-331	JJ	denotes	mature
T6164	332-335	NN	denotes	HKI
T6168	336-337	-LRB-	denotes	(
T6169	337-343	NN	denotes	Figure
T6170	344-345	CD	denotes	1
T6171	345-346	-RRB-	denotes	)
T6172	346-347	.	denotes	.
T6173	347-549	sentence	denotes	Cox11 inhibits noncompetitively the activity of HKI with ~2–3 molecules of Cox11 (assuming formation of Cox11 dimer) required to inhibit completely the activity of a molecule of HKI (Figure 2A and 2B).
T6174	348-353	NN	denotes	Cox11
T6175	354-362	VBZ	denotes	inhibits
T6176	363-379	RB	denotes	noncompetitively
T6177	380-383	DT	denotes	the
T6178	384-392	NN	denotes	activity
T6179	393-395	IN	denotes	of
T6180	396-399	NN	denotes	HKI
T6181	400-404	IN	denotes	with
T6183	405-406	SYM	denotes	~
T6185	406-407	CD	denotes	2
T6186	407-408	SYM	denotes	–
T6184	408-409	CD	denotes	3
T6187	410-419	NNS	denotes	molecules
T6188	420-422	IN	denotes	of
T6189	423-428	NN	denotes	Cox11
T6190	429-430	-LRB-	denotes	(
T6191	430-438	VBG	denotes	assuming
T6192	439-448	NN	denotes	formation
T6193	449-451	IN	denotes	of
T6194	452-457	NN	denotes	Cox11
T6195	458-463	NN	denotes	dimer
T6196	463-464	-RRB-	denotes	)
T6182	465-473	VBN	denotes	required
T6197	474-476	TO	denotes	to
T6198	477-484	VB	denotes	inhibit
T6199	485-495	RB	denotes	completely
T6200	496-499	DT	denotes	the
T6201	500-508	NN	denotes	activity
T6202	509-511	IN	denotes	of
T6203	512-513	DT	denotes	a
T6204	514-522	NN	denotes	molecule
T6205	523-525	IN	denotes	of
T6206	526-529	NN	denotes	HKI
T6207	530-531	-LRB-	denotes	(
T6209	531-537	NN	denotes	Figure
T6208	538-540	NN	denotes	2A
T6210	541-544	CC	denotes	and
T6211	545-547	NN	denotes	2B
T6212	547-548	-RRB-	denotes	)
T6213	548-549	.	denotes	.
T6214	549-704	sentence	denotes	Cox11 sequesters HKI by binding to HKI at a site that is distinct from the active site and effectively reduces the availability of [HKI]tot for catalysis.
T6215	550-555	NN	denotes	Cox11
T6216	556-566	VBZ	denotes	sequesters
T6217	567-570	NN	denotes	HKI
T6218	571-573	IN	denotes	by
T6219	574-581	VBG	denotes	binding
T6220	582-584	IN	denotes	to
T6221	585-588	NN	denotes	HKI
T6222	589-591	IN	denotes	at
T6223	592-593	DT	denotes	a
T6224	594-598	NN	denotes	site
T6225	599-603	WDT	denotes	that
T6226	604-606	VBZ	denotes	is
T6227	607-615	JJ	denotes	distinct
T6228	616-620	IN	denotes	from
T6229	621-624	DT	denotes	the
T6231	625-631	JJ	denotes	active
T6230	632-636	NN	denotes	site
T6232	637-640	CC	denotes	and
T6233	641-652	RB	denotes	effectively
T6234	653-660	VBZ	denotes	reduces
T6235	661-664	DT	denotes	the
T6236	665-677	NN	denotes	availability
T6237	678-680	IN	denotes	of
T6238	681-682	-LRB-	denotes	[
T6240	682-685	NN	denotes	HKI
T6241	685-686	-RRB-	denotes	]
T6239	686-689	NN	denotes	tot
T6242	690-693	IN	denotes	for
T6243	694-703	NN	denotes	catalysis
T6244	703-704	.	denotes	.
T6245	704-858	sentence	denotes	This is reflected by a reduction of the V max of HKI without significantly affecting the K m of the active site of HKI toward glucose (Figure 2A and 2B).
T6246	705-709	DT	denotes	This
T6248	710-712	VBZ	denotes	is
T6247	713-722	VBN	denotes	reflected
T6249	723-725	IN	denotes	by
T6250	726-727	DT	denotes	a
T6251	728-737	NN	denotes	reduction
T6252	738-740	IN	denotes	of
T6253	741-744	DT	denotes	the
T6254	745-750	NN	denotes	V max
T6255	751-753	IN	denotes	of
T6256	754-757	NN	denotes	HKI
T6257	758-765	IN	denotes	without
T6258	766-779	RB	denotes	significantly
T6259	780-789	VBG	denotes	affecting
T6260	790-793	DT	denotes	the
T6261	794-797	NN	denotes	K m
T6262	798-800	IN	denotes	of
T6263	801-804	DT	denotes	the
T6265	805-811	JJ	denotes	active
T6264	812-816	NN	denotes	site
T6266	817-819	IN	denotes	of
T6267	820-823	NN	denotes	HKI
T6268	824-830	IN	denotes	toward
T6269	831-838	NN	denotes	glucose
T6270	839-840	-LRB-	denotes	(
T6272	840-846	NN	denotes	Figure
T6271	847-849	NN	denotes	2A
T6273	850-853	CC	denotes	and
T6274	854-856	NN	denotes	2B
T6275	856-857	-RRB-	denotes	)
T6276	857-858	.	denotes	.
T6277	858-1022	sentence	denotes	The inhibitory property of Cox11 over HKI is suppressed by RanBP2 (Figure 2C), which by itself has a weak but significant inhibitory activity over HKI (Figure 2D).
T6278	859-862	DT	denotes	The
T6280	863-873	JJ	denotes	inhibitory
T6279	874-882	NN	denotes	property
T6282	883-885	IN	denotes	of
T6283	886-891	NN	denotes	Cox11
T6284	892-896	IN	denotes	over
T6285	897-900	NN	denotes	HKI
T6286	901-903	VBZ	denotes	is
T6281	904-914	VBN	denotes	suppressed
T6287	915-917	IN	denotes	by
T6288	918-924	NN	denotes	RanBP2
T6289	925-926	-LRB-	denotes	(
T6291	926-932	NN	denotes	Figure
T6290	933-935	NN	denotes	2C
T6292	935-936	-RRB-	denotes	)
T6293	936-938	,	denotes	,
T6294	938-943	WDT	denotes	which
T6296	944-946	IN	denotes	by
T6297	947-953	PRP	denotes	itself
T6295	954-957	VBZ	denotes	has
T6298	958-959	DT	denotes	a
T6300	960-964	JJ	denotes	weak
T6301	965-968	CC	denotes	but
T6302	969-980	JJ	denotes	significant
T6303	981-991	JJ	denotes	inhibitory
T6299	992-1000	NN	denotes	activity
T6304	1001-1005	IN	denotes	over
T6305	1006-1009	NN	denotes	HKI
T6306	1010-1011	-LRB-	denotes	(
T6308	1011-1017	NN	denotes	Figure
T6307	1018-1020	NN	denotes	2D
T6309	1020-1021	-RRB-	denotes	)
T6310	1021-1022	.	denotes	.
T6311	1022-1311	sentence	denotes	The sub-stochiometry effect of the LD of RanBP2 over the inhibition of HKI by Cox11 supports that a LD-dependent chaperonin-like mechanism underlies the suppression of Cox11-dependent inhibition of HKI by RanBP2, and that RanBP2 acts as a molecular “buffer” over HK1 and Cox11 activities.
T6312	1023-1026	DT	denotes	The
T6314	1027-1043	JJ	denotes	sub-stochiometry
T6313	1044-1050	NN	denotes	effect
T6316	1051-1053	IN	denotes	of
T6317	1054-1057	DT	denotes	the
T6318	1058-1060	NN	denotes	LD
T6319	1061-1063	IN	denotes	of
T6320	1064-1070	NN	denotes	RanBP2
T6321	1071-1075	IN	denotes	over
T6322	1076-1079	DT	denotes	the
T6323	1080-1090	NN	denotes	inhibition
T6324	1091-1093	IN	denotes	of
T6325	1094-1097	NN	denotes	HKI
T6326	1098-1100	IN	denotes	by
T6327	1101-1106	NN	denotes	Cox11
T6315	1107-1115	VBZ	denotes	supports
T6328	1116-1120	IN	denotes	that
T6330	1121-1122	DT	denotes	a
T6332	1123-1125	NN	denotes	LD
T6334	1125-1126	HYPH	denotes	-
T6333	1126-1135	JJ	denotes	dependent
T6335	1136-1146	NN	denotes	chaperonin
T6337	1146-1147	HYPH	denotes	-
T6336	1147-1151	JJ	denotes	like
T6331	1152-1161	NN	denotes	mechanism
T6329	1162-1171	VBZ	denotes	underlies
T6338	1172-1175	DT	denotes	the
T6339	1176-1187	NN	denotes	suppression
T6340	1188-1190	IN	denotes	of
T6341	1191-1196	JJ	denotes	Cox11
T6343	1196-1197	HYPH	denotes	-
T6342	1197-1206	JJ	denotes	dependent
T6344	1207-1217	NN	denotes	inhibition
T6345	1218-1220	IN	denotes	of
T6346	1221-1224	NN	denotes	HKI
T6347	1225-1227	IN	denotes	by
T6348	1228-1234	NN	denotes	RanBP2
T6349	1234-1236	,	denotes	,
T6350	1236-1239	CC	denotes	and
T6351	1240-1244	IN	denotes	that
T6353	1245-1251	NN	denotes	RanBP2
T6352	1252-1256	VBZ	denotes	acts
T6354	1257-1259	IN	denotes	as
T6355	1260-1261	DT	denotes	a
T6357	1262-1271	JJ	denotes	molecular
T6358	1272-1273	``	denotes	“
T6356	1273-1279	NN	denotes	buffer
T6359	1279-1280	''	denotes	”
T6360	1281-1285	IN	denotes	over
T6361	1286-1289	NN	denotes	HK1
T6363	1290-1293	CC	denotes	and
T6364	1294-1299	NN	denotes	Cox11
T6362	1300-1310	NNS	denotes	activities
T6365	1310-1311	.	denotes	.
T6366	1311-1484	sentence	denotes	The partial loss of the RanBP2 chaperone activity in RanBP2+/− mice also leads to deficits in the sequestration of HKI in the ellipsoid compartment of photosensory neurons.
T6367	1312-1315	DT	denotes	The
T6369	1316-1323	JJ	denotes	partial
T6368	1324-1328	NN	denotes	loss
T6371	1329-1331	IN	denotes	of
T6372	1332-1335	DT	denotes	the
T6374	1336-1342	NN	denotes	RanBP2
T6375	1343-1352	NN	denotes	chaperone
T6373	1353-1361	NN	denotes	activity
T6376	1362-1364	IN	denotes	in
T6377	1365-1371	NN	denotes	RanBP2
T6379	1371-1372	SYM	denotes	+
T6380	1372-1373	HYPH	denotes	/
T6381	1373-1374	SYM	denotes	−
T6378	1375-1379	NNS	denotes	mice
T6382	1380-1384	RB	denotes	also
T6370	1385-1390	VBZ	denotes	leads
T6383	1391-1393	IN	denotes	to
T6384	1394-1402	NNS	denotes	deficits
T6385	1403-1405	IN	denotes	in
T6386	1406-1409	DT	denotes	the
T6387	1410-1423	NN	denotes	sequestration
T6388	1424-1426	IN	denotes	of
T6389	1427-1430	NN	denotes	HKI
T6390	1431-1433	IN	denotes	in
T6391	1434-1437	DT	denotes	the
T6393	1438-1447	JJ	denotes	ellipsoid
T6392	1448-1459	NN	denotes	compartment
T6394	1460-1462	IN	denotes	of
T6395	1463-1475	JJ	denotes	photosensory
T6396	1476-1483	NNS	denotes	neurons
T6397	1483-1484	.	denotes	.
T6398	1484-1587	sentence	denotes	This possibly underlies the mistargeting of HKI to the myoid compartment of these neurons (Figure S2).
T6399	1485-1489	DT	denotes	This
T6401	1490-1498	RB	denotes	possibly
T6400	1499-1508	VBZ	denotes	underlies
T6402	1509-1512	DT	denotes	the
T6403	1513-1525	NN	denotes	mistargeting
T6404	1526-1528	IN	denotes	of
T6405	1529-1532	NN	denotes	HKI
T6406	1533-1535	IN	denotes	to
T6407	1536-1539	DT	denotes	the
T6409	1540-1545	JJ	denotes	myoid
T6408	1546-1557	NN	denotes	compartment
T6410	1558-1560	IN	denotes	of
T6411	1561-1566	DT	denotes	these
T6412	1567-1574	NNS	denotes	neurons
T6413	1575-1576	-LRB-	denotes	(
T6415	1576-1582	NN	denotes	Figure
T6414	1583-1585	NN	denotes	S2
T6416	1585-1586	-RRB-	denotes	)
T6417	1586-1587	.	denotes	.
T6418	1587-1874	sentence	denotes	The data support that the ultimate pathophysiological outcome in HKI, caused by a reduction in RanBP2 levels and its chaperone activity, is the selective degradation of HKI as reflected by the reduced levels of HKI (and ATP) but not of other mitochondrial and NPC components (Figure 5).
T6419	1588-1591	DT	denotes	The
T6420	1592-1596	NNS	denotes	data
T6421	1597-1604	VBP	denotes	support
T6422	1605-1609	IN	denotes	that
T6424	1610-1613	DT	denotes	the
T6426	1614-1622	JJ	denotes	ultimate
T6427	1623-1641	JJ	denotes	pathophysiological
T6425	1642-1649	NN	denotes	outcome
T6428	1650-1652	IN	denotes	in
T6429	1653-1656	NN	denotes	HKI
T6430	1656-1658	,	denotes	,
T6431	1658-1664	VBN	denotes	caused
T6432	1665-1667	IN	denotes	by
T6433	1668-1669	DT	denotes	a
T6434	1670-1679	NN	denotes	reduction
T6435	1680-1682	IN	denotes	in
T6436	1683-1689	NN	denotes	RanBP2
T6437	1690-1696	NNS	denotes	levels
T6438	1697-1700	CC	denotes	and
T6439	1701-1704	PRP$	denotes	its
T6441	1705-1714	NN	denotes	chaperone
T6440	1715-1723	NN	denotes	activity
T6442	1723-1725	,	denotes	,
T6423	1725-1727	VBZ	denotes	is
T6443	1728-1731	DT	denotes	the
T6445	1732-1741	JJ	denotes	selective
T6444	1742-1753	NN	denotes	degradation
T6446	1754-1756	IN	denotes	of
T6447	1757-1760	NN	denotes	HKI
T6448	1761-1763	IN	denotes	as
T6449	1764-1773	VBN	denotes	reflected
T6450	1774-1776	IN	denotes	by
T6451	1777-1780	DT	denotes	the
T6453	1781-1788	VBN	denotes	reduced
T6452	1789-1795	NNS	denotes	levels
T6454	1796-1798	IN	denotes	of
T6455	1799-1802	NN	denotes	HKI
T6456	1803-1804	-LRB-	denotes	(
T6457	1804-1807	CC	denotes	and
T6458	1808-1811	NN	denotes	ATP
T6459	1811-1812	-RRB-	denotes	)
T6460	1813-1816	CC	denotes	but
T6461	1817-1820	RB	denotes	not
T6462	1821-1823	IN	denotes	of
T6463	1824-1829	JJ	denotes	other
T6465	1830-1843	JJ	denotes	mitochondrial
T6466	1844-1847	CC	denotes	and
T6467	1848-1851	NN	denotes	NPC
T6464	1852-1862	NNS	denotes	components
T6468	1863-1864	-LRB-	denotes	(
T6469	1864-1870	NN	denotes	Figure
T6470	1871-1872	CD	denotes	5
T6471	1872-1873	-RRB-	denotes	)
T6472	1873-1874	.	denotes	.
T6473	1874-2185	sentence	denotes	Through this process, it is also possible that deficits in RanBP2 cause a disturbance in the equilibrium between Cox11, HK1, and RanBP2 by leading to an increase of the inhibitory activity of Cox11 over HKI that promotes the uncoupling of the interaction of HKI from RanBP2, ultimately causing HKI degradation.
T6474	1875-1882	IN	denotes	Through
T6476	1883-1887	DT	denotes	this
T6477	1888-1895	NN	denotes	process
T6478	1895-1897	,	denotes	,
T6479	1897-1899	PRP	denotes	it
T6475	1900-1902	VBZ	denotes	is
T6480	1903-1907	RB	denotes	also
T6481	1908-1916	JJ	denotes	possible
T6482	1917-1921	IN	denotes	that
T6484	1922-1930	NNS	denotes	deficits
T6485	1931-1933	IN	denotes	in
T6486	1934-1940	NN	denotes	RanBP2
T6483	1941-1946	VBP	denotes	cause
T6487	1947-1948	DT	denotes	a
T6488	1949-1960	NN	denotes	disturbance
T6489	1961-1963	IN	denotes	in
T6490	1964-1967	DT	denotes	the
T6491	1968-1979	NN	denotes	equilibrium
T6492	1980-1987	IN	denotes	between
T6493	1988-1993	NN	denotes	Cox11
T6494	1993-1995	,	denotes	,
T6495	1995-1998	NN	denotes	HK1
T6496	1998-2000	,	denotes	,
T6497	2000-2003	CC	denotes	and
T6498	2004-2010	NN	denotes	RanBP2
T6499	2011-2013	IN	denotes	by
T6500	2014-2021	VBG	denotes	leading
T6501	2022-2024	IN	denotes	to
T6502	2025-2027	DT	denotes	an
T6503	2028-2036	NN	denotes	increase
T6504	2037-2039	IN	denotes	of
T6505	2040-2043	DT	denotes	the
T6507	2044-2054	JJ	denotes	inhibitory
T6506	2055-2063	NN	denotes	activity
T6508	2064-2066	IN	denotes	of
T6509	2067-2072	NN	denotes	Cox11
T6510	2073-2077	IN	denotes	over
T6511	2078-2081	NN	denotes	HKI
T6512	2082-2086	WDT	denotes	that
T6513	2087-2095	VBZ	denotes	promotes
T6514	2096-2099	DT	denotes	the
T6515	2100-2110	NN	denotes	uncoupling
T6516	2111-2113	IN	denotes	of
T6517	2114-2117	DT	denotes	the
T6518	2118-2129	NN	denotes	interaction
T6519	2130-2132	IN	denotes	of
T6520	2133-2136	NN	denotes	HKI
T6521	2137-2141	IN	denotes	from
T6522	2142-2148	NN	denotes	RanBP2
T6523	2148-2150	,	denotes	,
T6524	2150-2160	RB	denotes	ultimately
T6525	2161-2168	VBG	denotes	causing
T6526	2169-2172	NN	denotes	HKI
T6527	2173-2184	NN	denotes	degradation
T6528	2184-2185	.	denotes	.
T6529	2185-2366	sentence	denotes	Regardless, lower levels of HKI likely contribute to the decreased levels in ATP, slower growth rates, and diminished ability to metabolize glucose of RanBP2+/− mice (Figures 5–7).
T6530	2186-2196	RB	denotes	Regardless
T6532	2196-2198	,	denotes	,
T6533	2198-2203	JJR	denotes	lower
T6534	2204-2210	NNS	denotes	levels
T6535	2211-2213	IN	denotes	of
T6536	2214-2217	NN	denotes	HKI
T6537	2218-2224	RB	denotes	likely
T6531	2225-2235	VBP	denotes	contribute
T6538	2236-2238	IN	denotes	to
T6539	2239-2242	DT	denotes	the
T6541	2243-2252	VBN	denotes	decreased
T6540	2253-2259	NNS	denotes	levels
T6542	2260-2262	IN	denotes	in
T6543	2263-2266	NN	denotes	ATP
T6544	2266-2268	,	denotes	,
T6545	2268-2274	JJR	denotes	slower
T6547	2275-2281	NN	denotes	growth
T6546	2282-2287	NNS	denotes	rates
T6548	2287-2289	,	denotes	,
T6549	2289-2292	CC	denotes	and
T6550	2293-2303	VBN	denotes	diminished
T6551	2304-2311	NN	denotes	ability
T6552	2312-2314	TO	denotes	to
T6553	2315-2325	VB	denotes	metabolize
T6554	2326-2333	NN	denotes	glucose
T6555	2334-2336	IN	denotes	of
T6556	2337-2343	NN	denotes	RanBP2
T6558	2343-2344	SYM	denotes	+
T6559	2344-2345	HYPH	denotes	/
T6560	2345-2346	SYM	denotes	−
T6557	2347-2351	NNS	denotes	mice
T6561	2352-2353	-LRB-	denotes	(
T6562	2353-2360	NNS	denotes	Figures
T6563	2361-2362	CD	denotes	5
T6564	2362-2363	SYM	denotes	–
T6565	2363-2364	CD	denotes	7
T6566	2364-2365	-RRB-	denotes	)
T6567	2365-2366	.	denotes	.
T6568	2366-2517	sentence	denotes	As discussed subsequently, the ATP deficits in the retina likely account for the reduced electrophysiological responses of retinal neurons (Figure 8).
T6569	2367-2369	IN	denotes	As
T6570	2370-2379	VBN	denotes	discussed
T6572	2380-2392	RB	denotes	subsequently
T6573	2392-2394	,	denotes	,
T6574	2394-2397	DT	denotes	the
T6576	2398-2401	NN	denotes	ATP
T6575	2402-2410	NNS	denotes	deficits
T6577	2411-2413	IN	denotes	in
T6578	2414-2417	DT	denotes	the
T6579	2418-2424	NN	denotes	retina
T6580	2425-2431	RB	denotes	likely
T6571	2432-2439	VBP	denotes	account
T6581	2440-2443	IN	denotes	for
T6582	2444-2447	DT	denotes	the
T6584	2448-2455	VBN	denotes	reduced
T6585	2456-2476	JJ	denotes	electrophysiological
T6583	2477-2486	NNS	denotes	responses
T6586	2487-2489	IN	denotes	of
T6587	2490-2497	JJ	denotes	retinal
T6588	2498-2505	NNS	denotes	neurons
T6589	2506-2507	-LRB-	denotes	(
T6590	2507-2513	NN	denotes	Figure
T6591	2514-2515	CD	denotes	8
T6592	2515-2516	-RRB-	denotes	)
T6593	2516-2517	.	denotes	.
T6594	2517-2610	sentence	denotes	Various domains of RanBP2 have been previously implicated with a chaperone role in the cell.
T6595	2518-2525	JJ	denotes	Various
T6596	2526-2533	NNS	denotes	domains
T6598	2534-2536	IN	denotes	of
T6599	2537-2543	NN	denotes	RanBP2
T6600	2544-2548	VBP	denotes	have
T6601	2549-2553	VBN	denotes	been
T6602	2554-2564	RB	denotes	previously
T6597	2565-2575	VBN	denotes	implicated
T6603	2576-2580	IN	denotes	with
T6604	2581-2582	DT	denotes	a
T6606	2583-2592	NN	denotes	chaperone
T6605	2593-2597	NN	denotes	role
T6607	2598-2600	IN	denotes	in
T6608	2601-2604	DT	denotes	the
T6609	2605-2609	NN	denotes	cell
T6610	2609-2610	.	denotes	.
T6611	2610-2905	sentence	denotes	These include the enhancement of the biogenesis of red/green opsin by the combination of the RBD4-CY domains [6,7] and the stabilization by the Ran-binding domains of RanBP2 of the guanosine triphosphate-bound conformational state of RanGTPase and interaction of Ran with importin-β [11,40,41].
T6612	2611-2616	DT	denotes	These
T6613	2617-2624	VBP	denotes	include
T6614	2625-2628	DT	denotes	the
T6615	2629-2640	NN	denotes	enhancement
T6616	2641-2643	IN	denotes	of
T6617	2644-2647	DT	denotes	the
T6618	2648-2658	NN	denotes	biogenesis
T6619	2659-2661	IN	denotes	of
T6620	2662-2665	JJ	denotes	red
T6622	2665-2666	HYPH	denotes	/
T6621	2666-2671	JJ	denotes	green
T6623	2672-2677	NN	denotes	opsin
T6624	2678-2680	IN	denotes	by
T6625	2681-2684	DT	denotes	the
T6626	2685-2696	NN	denotes	combination
T6627	2697-2699	IN	denotes	of
T6628	2700-2703	DT	denotes	the
T6630	2704-2708	NN	denotes	RBD4
T6632	2708-2709	HYPH	denotes	-
T6631	2709-2711	NN	denotes	CY
T6629	2712-2719	NNS	denotes	domains
T6633	2720-2721	-LRB-	denotes	[
T6635	2721-2722	CD	denotes	6
T6636	2722-2723	,	denotes	,
T6634	2723-2724	CD	denotes	7
T6637	2724-2725	-RRB-	denotes	]
T6638	2726-2729	CC	denotes	and
T6639	2730-2733	DT	denotes	the
T6640	2734-2747	NN	denotes	stabilization
T6641	2748-2750	IN	denotes	by
T6642	2751-2754	DT	denotes	the
T6644	2755-2758	NN	denotes	Ran
T6646	2758-2759	HYPH	denotes	-
T6645	2759-2766	VBG	denotes	binding
T6643	2767-2774	NNS	denotes	domains
T6647	2775-2777	IN	denotes	of
T6648	2778-2784	NN	denotes	RanBP2
T6649	2785-2787	IN	denotes	of
T6650	2788-2791	DT	denotes	the
T6652	2792-2801	NN	denotes	guanosine
T6653	2802-2814	NN	denotes	triphosphate
T6655	2814-2815	HYPH	denotes	-
T6654	2815-2820	VBN	denotes	bound
T6656	2821-2835	JJ	denotes	conformational
T6651	2836-2841	NN	denotes	state
T6657	2842-2844	IN	denotes	of
T6658	2845-2854	NN	denotes	RanGTPase
T6659	2855-2858	CC	denotes	and
T6660	2859-2870	NN	denotes	interaction
T6661	2871-2873	IN	denotes	of
T6662	2874-2877	NN	denotes	Ran
T6663	2878-2882	IN	denotes	with
T6664	2883-2891	NN	denotes	importin
T6666	2891-2892	HYPH	denotes	-
T6665	2892-2893	NN	denotes	β
T6667	2894-2895	-LRB-	denotes	[
T6669	2895-2897	CD	denotes	11
T6670	2897-2898	,	denotes	,
T6671	2898-2900	CD	denotes	40
T6672	2900-2901	,	denotes	,
T6668	2901-2903	CD	denotes	41
T6673	2903-2904	-RRB-	denotes	]
T6674	2904-2905	.	denotes	.
T6675	2905-3103	sentence	denotes	The data herein show that the multi-chaperone role of RanBP2 extends also to its LD in light of its ability to associate to distinct folding species of Cox11 and to prevent HKI from being degraded.
T6676	2906-2909	DT	denotes	The
T6677	2910-2914	NNS	denotes	data
T6679	2915-2921	RB	denotes	herein
T6678	2922-2926	VBP	denotes	show
T6680	2927-2931	IN	denotes	that
T6682	2932-2935	DT	denotes	the
T6684	2936-2951	JJ	denotes	multi-chaperone
T6683	2952-2956	NN	denotes	role
T6685	2957-2959	IN	denotes	of
T6686	2960-2966	NN	denotes	RanBP2
T6681	2967-2974	VBZ	denotes	extends
T6687	2975-2979	RB	denotes	also
T6688	2980-2982	IN	denotes	to
T6689	2983-2986	PRP$	denotes	its
T6690	2987-2989	NN	denotes	LD
T6691	2990-2992	IN	denotes	in
T6692	2993-2998	NN	denotes	light
T6693	2999-3001	IN	denotes	of
T6694	3002-3005	PRP$	denotes	its
T6695	3006-3013	NN	denotes	ability
T6696	3014-3016	TO	denotes	to
T6697	3017-3026	VB	denotes	associate
T6698	3027-3029	IN	denotes	to
T6699	3030-3038	JJ	denotes	distinct
T6701	3039-3046	NN	denotes	folding
T6700	3047-3054	NNS	denotes	species
T6702	3055-3057	IN	denotes	of
T6703	3058-3063	NN	denotes	Cox11
T6704	3064-3067	CC	denotes	and
T6705	3068-3070	TO	denotes	to
T6706	3071-3078	VB	denotes	prevent
T6707	3079-3082	NN	denotes	HKI
T6708	3083-3087	IN	denotes	from
T6709	3088-3093	VBG	denotes	being
T6710	3094-3102	VBN	denotes	degraded
T6711	3102-3103	.	denotes	.
T6712	3103-3224	sentence	denotes	This chaperone function is likely to be complemented by other partners of RanBP2 with similar and pleiotropic functions.
T6713	3104-3108	DT	denotes	This
T6715	3109-3118	NN	denotes	chaperone
T6714	3119-3127	NN	denotes	function
T6716	3128-3130	VBZ	denotes	is
T6717	3131-3137	JJ	denotes	likely
T6718	3138-3140	TO	denotes	to
T6720	3141-3143	VB	denotes	be
T6719	3144-3156	VBN	denotes	complemented
T6721	3157-3159	IN	denotes	by
T6722	3160-3165	JJ	denotes	other
T6723	3166-3174	NNS	denotes	partners
T6724	3175-3177	IN	denotes	of
T6725	3178-3184	NN	denotes	RanBP2
T6726	3185-3189	IN	denotes	with
T6727	3190-3197	JJ	denotes	similar
T6729	3198-3201	CC	denotes	and
T6730	3202-3213	JJ	denotes	pleiotropic
T6728	3214-3223	NNS	denotes	functions
T6731	3223-3224	.	denotes	.
T6732	3224-3639	sentence	denotes	For example, the combination of the CLD of RanBP2 with several subunits of the 19S cap of the proteasome [14], and of its neighboring internal repeat, W1W2/IR with the E3-ubiquitin ligase, parkin [20], and the E2 SUMO-1-conjugating protein, Ubc9 [15] may contribute to the down-regulation of HKI by 26S proteasome-mediated proteolysis and modulation of the molecular and subcellular partitioning of these partners.
T6733	3225-3228	IN	denotes	For
T6735	3229-3236	NN	denotes	example
T6736	3236-3238	,	denotes	,
T6737	3238-3241	DT	denotes	the
T6738	3242-3253	NN	denotes	combination
T6739	3254-3256	IN	denotes	of
T6740	3257-3260	DT	denotes	the
T6741	3261-3264	NN	denotes	CLD
T6742	3265-3267	IN	denotes	of
T6743	3268-3274	NN	denotes	RanBP2
T6744	3275-3279	IN	denotes	with
T6745	3280-3287	JJ	denotes	several
T6746	3288-3296	NNS	denotes	subunits
T6747	3297-3299	IN	denotes	of
T6748	3300-3303	DT	denotes	the
T6750	3304-3307	NN	denotes	19S
T6749	3308-3311	NN	denotes	cap
T6751	3312-3314	IN	denotes	of
T6752	3315-3318	DT	denotes	the
T6753	3319-3329	NN	denotes	proteasome
T6754	3330-3331	-LRB-	denotes	[
T6755	3331-3333	CD	denotes	14
T6756	3333-3334	-RRB-	denotes	]
T6757	3334-3336	,	denotes	,
T6758	3336-3339	CC	denotes	and
T6759	3340-3342	IN	denotes	of
T6761	3343-3346	PRP$	denotes	its
T6763	3347-3358	VBG	denotes	neighboring
T6764	3359-3367	JJ	denotes	internal
T6762	3368-3374	NN	denotes	repeat
T6765	3374-3376	,	denotes	,
T6766	3376-3380	NN	denotes	W1W2
T6768	3380-3381	HYPH	denotes	/
T6767	3381-3383	NN	denotes	IR
T6760	3384-3388	IN	denotes	with
T6769	3389-3392	DT	denotes	the
T6771	3393-3395	NN	denotes	E3
T6773	3395-3396	HYPH	denotes	-
T6772	3396-3405	NN	denotes	ubiquitin
T6770	3406-3412	NN	denotes	ligase
T6774	3412-3414	,	denotes	,
T6775	3414-3420	NN	denotes	parkin
T6776	3421-3422	-LRB-	denotes	[
T6777	3422-3424	CD	denotes	20
T6778	3424-3425	-RRB-	denotes	]
T6779	3425-3427	,	denotes	,
T6780	3427-3430	CC	denotes	and
T6781	3431-3434	DT	denotes	the
T6783	3435-3437	NN	denotes	E2
T6784	3438-3442	NN	denotes	SUMO
T6786	3442-3443	HYPH	denotes	-
T6787	3443-3444	CD	denotes	1
T6788	3444-3445	HYPH	denotes	-
T6785	3445-3456	VBG	denotes	conjugating
T6782	3457-3464	NN	denotes	protein
T6789	3464-3466	,	denotes	,
T6790	3466-3470	NN	denotes	Ubc9
T6791	3471-3472	-LRB-	denotes	[
T6792	3472-3474	CD	denotes	15
T6793	3474-3475	-RRB-	denotes	]
T6794	3476-3479	MD	denotes	may
T6734	3480-3490	VB	denotes	contribute
T6795	3491-3493	IN	denotes	to
T6796	3494-3497	DT	denotes	the
T6798	3498-3502	JJ	denotes	down
T6799	3502-3503	HYPH	denotes	-
T6797	3503-3513	NN	denotes	regulation
T6800	3514-3516	IN	denotes	of
T6801	3517-3520	NN	denotes	HKI
T6802	3521-3523	IN	denotes	by
T6803	3524-3527	NN	denotes	26S
T6804	3528-3538	NN	denotes	proteasome
T6806	3538-3539	HYPH	denotes	-
T6805	3539-3547	VBN	denotes	mediated
T6807	3548-3559	NN	denotes	proteolysis
T6808	3560-3563	CC	denotes	and
T6809	3564-3574	NN	denotes	modulation
T6810	3575-3577	IN	denotes	of
T6811	3578-3581	DT	denotes	the
T6813	3582-3591	JJ	denotes	molecular
T6814	3592-3595	CC	denotes	and
T6815	3596-3607	JJ	denotes	subcellular
T6812	3608-3620	NN	denotes	partitioning
T6816	3621-3623	IN	denotes	of
T6817	3624-3629	DT	denotes	these
T6818	3630-3638	NNS	denotes	partners
T6819	3638-3639	.	denotes	.
T6820	3639-3894	sentence	denotes	In this regard, it will be interesting to probe whether parkin also causes deficits in HKI in dopaminergic neurons, since parkin was reported to modulate RanBP2 turnover [20], and parkin loss-of-function also causes energy and growth deficits [26–29,42].
T6821	3640-3642	IN	denotes	In
T6823	3643-3647	DT	denotes	this
T6824	3648-3654	NN	denotes	regard
T6825	3654-3656	,	denotes	,
T6826	3656-3658	PRP	denotes	it
T6827	3659-3663	MD	denotes	will
T6822	3664-3666	VB	denotes	be
T6828	3667-3678	JJ	denotes	interesting
T6829	3679-3681	TO	denotes	to
T6830	3682-3687	VB	denotes	probe
T6831	3688-3695	IN	denotes	whether
T6833	3696-3702	NN	denotes	parkin
T6834	3703-3707	RB	denotes	also
T6832	3708-3714	VBZ	denotes	causes
T6835	3715-3723	NNS	denotes	deficits
T6836	3724-3726	IN	denotes	in
T6837	3727-3730	NN	denotes	HKI
T6838	3731-3733	IN	denotes	in
T6839	3734-3746	JJ	denotes	dopaminergic
T6840	3747-3754	NNS	denotes	neurons
T6841	3754-3756	,	denotes	,
T6842	3756-3761	IN	denotes	since
T6844	3762-3768	NN	denotes	parkin
T6845	3769-3772	VBD	denotes	was
T6843	3773-3781	VBN	denotes	reported
T6846	3782-3784	TO	denotes	to
T6847	3785-3793	VB	denotes	modulate
T6848	3794-3800	NN	denotes	RanBP2
T6849	3801-3809	NN	denotes	turnover
T6850	3810-3811	-LRB-	denotes	[
T6851	3811-3813	CD	denotes	20
T6852	3813-3814	-RRB-	denotes	]
T6853	3814-3816	,	denotes	,
T6854	3816-3819	CC	denotes	and
T6855	3820-3826	NN	denotes	parkin
T6856	3827-3831	NN	denotes	loss
T6858	3831-3832	HYPH	denotes	-
T6859	3832-3834	IN	denotes	of
T6860	3834-3835	HYPH	denotes	-
T6861	3835-3843	NN	denotes	function
T6862	3844-3848	RB	denotes	also
T6857	3849-3855	VBZ	denotes	causes
T6863	3856-3862	NN	denotes	energy
T6865	3863-3866	CC	denotes	and
T6866	3867-3873	NN	denotes	growth
T6864	3874-3882	NNS	denotes	deficits
T6867	3883-3884	-LRB-	denotes	[
T6869	3884-3886	CD	denotes	26
T6870	3886-3887	SYM	denotes	–
T6871	3887-3889	CD	denotes	29
T6872	3889-3890	,	denotes	,
T6868	3890-3892	CD	denotes	42
T6873	3892-3893	-RRB-	denotes	]
T6874	3893-3894	.	denotes	.
T6875	3894-4192	sentence	denotes	These data add a new dimension to the complexity of the regulation of the glycolytic pathway, in particular in the CNS, where glycolysis plays a major role in supplying energy and where the proteasome machinery may play a critical role in modulating components of the energy supply machinery [43].
T6876	3895-3900	DT	denotes	These
T6877	3901-3905	NNS	denotes	data
T6878	3906-3909	VBP	denotes	add
T6879	3910-3911	DT	denotes	a
T6881	3912-3915	JJ	denotes	new
T6880	3916-3925	NN	denotes	dimension
T6882	3926-3928	IN	denotes	to
T6883	3929-3932	DT	denotes	the
T6884	3933-3943	NN	denotes	complexity
T6885	3944-3946	IN	denotes	of
T6886	3947-3950	DT	denotes	the
T6887	3951-3961	NN	denotes	regulation
T6888	3962-3964	IN	denotes	of
T6889	3965-3968	DT	denotes	the
T6891	3969-3979	JJ	denotes	glycolytic
T6890	3980-3987	NN	denotes	pathway
T6892	3987-3989	,	denotes	,
T6893	3989-3991	IN	denotes	in
T6895	3992-4002	JJ	denotes	particular
T6894	4003-4005	IN	denotes	in
T6896	4006-4009	DT	denotes	the
T6897	4010-4013	NN	denotes	CNS
T6898	4013-4015	,	denotes	,
T6899	4015-4020	WRB	denotes	where
T6901	4021-4031	NN	denotes	glycolysis
T6900	4032-4037	VBZ	denotes	plays
T6902	4038-4039	DT	denotes	a
T6904	4040-4045	JJ	denotes	major
T6903	4046-4050	NN	denotes	role
T6905	4051-4053	IN	denotes	in
T6906	4054-4063	VBG	denotes	supplying
T6907	4064-4070	NN	denotes	energy
T6908	4071-4074	CC	denotes	and
T6909	4075-4080	WRB	denotes	where
T6911	4081-4084	DT	denotes	the
T6913	4085-4095	NN	denotes	proteasome
T6912	4096-4105	NN	denotes	machinery
T6914	4106-4109	MD	denotes	may
T6910	4110-4114	VB	denotes	play
T6915	4115-4116	DT	denotes	a
T6917	4117-4125	JJ	denotes	critical
T6916	4126-4130	NN	denotes	role
T6918	4131-4133	IN	denotes	in
T6919	4134-4144	VBG	denotes	modulating
T6920	4145-4155	NNS	denotes	components
T6921	4156-4158	IN	denotes	of
T6922	4159-4162	DT	denotes	the
T6924	4163-4169	NN	denotes	energy
T6925	4170-4176	NN	denotes	supply
T6923	4177-4186	NN	denotes	machinery
T6926	4187-4188	-LRB-	denotes	[
T6927	4188-4190	CD	denotes	43
T6928	4190-4191	-RRB-	denotes	]
T6929	4191-4192	.	denotes	.
T6930	4192-4441	sentence	denotes	This is further evidenced by the presence of genetic modifiers in RanBP2+/−mice on a mixed genetic background that compensates for deficits in RanBP2 and deregulation of its partners in glucose/energy homeostasis as observed in the coisogenic line.
T6931	4193-4197	DT	denotes	This
T6933	4198-4200	VBZ	denotes	is
T6934	4201-4208	RB	denotes	further
T6932	4209-4218	VBN	denotes	evidenced
T6935	4219-4221	IN	denotes	by
T6936	4222-4225	DT	denotes	the
T6937	4226-4234	NN	denotes	presence
T6938	4235-4237	IN	denotes	of
T6939	4238-4245	JJ	denotes	genetic
T6940	4246-4255	NNS	denotes	modifiers
T6941	4256-4258	IN	denotes	in
T6942	4259-4265	NN	denotes	RanBP2
T6944	4265-4266	SYM	denotes	+
T6945	4266-4267	HYPH	denotes	/
T6946	4267-4268	SYM	denotes	−
T6943	4268-4272	NNS	denotes	mice
T6947	4273-4275	IN	denotes	on
T6948	4276-4277	DT	denotes	a
T6950	4278-4283	JJ	denotes	mixed
T6951	4284-4291	JJ	denotes	genetic
T6949	4292-4302	NN	denotes	background
T6952	4303-4307	WDT	denotes	that
T6953	4308-4319	VBZ	denotes	compensates
T6954	4320-4323	IN	denotes	for
T6955	4324-4332	NNS	denotes	deficits
T6956	4333-4335	IN	denotes	in
T6957	4336-4342	NN	denotes	RanBP2
T6958	4343-4346	CC	denotes	and
T6959	4347-4359	NN	denotes	deregulation
T6960	4360-4362	IN	denotes	of
T6961	4363-4366	PRP$	denotes	its
T6962	4367-4375	NNS	denotes	partners
T6963	4376-4378	IN	denotes	in
T6964	4379-4386	NN	denotes	glucose
T6966	4386-4387	HYPH	denotes	/
T6965	4387-4393	NN	denotes	energy
T6967	4394-4405	NN	denotes	homeostasis
T6968	4406-4408	IN	denotes	as
T6969	4409-4417	VBN	denotes	observed
T6970	4418-4420	IN	denotes	in
T6971	4421-4424	DT	denotes	the
T6973	4425-4435	JJ	denotes	coisogenic
T6972	4436-4440	NN	denotes	line
T6974	4440-4441	.	denotes	.
T6975	4441-4648	sentence	denotes	The presence of such compensatory mechanisms is also supported by the identification of a quantitative trait locus, which encompasses RanBP2, and modifies the expression of diabetes-related phenotypes [44].
T6976	4442-4445	DT	denotes	The
T6977	4446-4454	NN	denotes	presence
T6979	4455-4457	IN	denotes	of
T6980	4458-4462	JJ	denotes	such
T6982	4463-4475	JJ	denotes	compensatory
T6981	4476-4486	NNS	denotes	mechanisms
T6983	4487-4489	VBZ	denotes	is
T6984	4490-4494	RB	denotes	also
T6978	4495-4504	VBN	denotes	supported
T6985	4505-4507	IN	denotes	by
T6986	4508-4511	DT	denotes	the
T6987	4512-4526	NN	denotes	identification
T6988	4527-4529	IN	denotes	of
T6989	4530-4531	DT	denotes	a
T6991	4532-4544	JJ	denotes	quantitative
T6992	4545-4550	NN	denotes	trait
T6990	4551-4556	NN	denotes	locus
T6993	4556-4558	,	denotes	,
T6994	4558-4563	WDT	denotes	which
T6995	4564-4575	VBZ	denotes	encompasses
T6996	4576-4582	NN	denotes	RanBP2
T6997	4582-4584	,	denotes	,
T6998	4584-4587	CC	denotes	and
T6999	4588-4596	VBZ	denotes	modifies
T7000	4597-4600	DT	denotes	the
T7001	4601-4611	NN	denotes	expression
T7002	4612-4614	IN	denotes	of
T7003	4615-4623	NN	denotes	diabetes
T7005	4623-4624	HYPH	denotes	-
T7004	4624-4631	VBN	denotes	related
T7006	4632-4642	NNS	denotes	phenotypes
T7007	4643-4644	-LRB-	denotes	[
T7008	4644-4646	CD	denotes	44
T7009	4646-4647	-RRB-	denotes	]
T7010	4647-4648	.	denotes	.
T7011	4648-4756	sentence	denotes	The data herein show tissues with a decrease of RanBP2 and HKI levels mirror a reduction in the ATP levels.
T7012	4649-4652	DT	denotes	The
T7013	4653-4657	NNS	denotes	data
T7015	4658-4664	RB	denotes	herein
T7014	4665-4669	VBP	denotes	show
T7016	4670-4677	NNS	denotes	tissues
T7017	4678-4682	IN	denotes	with
T7018	4683-4684	DT	denotes	a
T7019	4685-4693	NN	denotes	decrease
T7020	4694-4696	IN	denotes	of
T7021	4697-4703	NN	denotes	RanBP2
T7022	4704-4707	CC	denotes	and
T7023	4708-4711	NN	denotes	HKI
T7024	4712-4718	NNS	denotes	levels
T7025	4719-4725	VBP	denotes	mirror
T7026	4726-4727	DT	denotes	a
T7027	4728-4737	NN	denotes	reduction
T7028	4738-4740	IN	denotes	in
T7029	4741-4744	DT	denotes	the
T7031	4745-4748	NN	denotes	ATP
T7030	4749-4755	NNS	denotes	levels
T7032	4755-4756	.	denotes	.
T7033	4756-5107	sentence	denotes	Since the constitutive Na+/K+ ATPase pump and the ATP-dependent conversion of glutamine to glutamate (both fundamental to maintain the electrical activity in the CNS) consumes the vast majority of the energy produced by the CNS [45–47], this likely underlies the suppression of the electrophysiological output responses of retinal neurons (Figure 8).
T7034	4757-4762	IN	denotes	Since
T7036	4763-4766	DT	denotes	the
T7038	4767-4779	JJ	denotes	constitutive
T7039	4780-4783	NN	denotes	Na+
T7041	4783-4784	HYPH	denotes	/
T7040	4784-4786	NN	denotes	K+
T7042	4787-4793	NN	denotes	ATPase
T7037	4794-4798	NN	denotes	pump
T7043	4799-4802	CC	denotes	and
T7044	4803-4806	DT	denotes	the
T7046	4807-4810	NN	denotes	ATP
T7048	4810-4811	HYPH	denotes	-
T7047	4811-4820	JJ	denotes	dependent
T7045	4821-4831	NN	denotes	conversion
T7049	4832-4834	IN	denotes	of
T7050	4835-4844	NN	denotes	glutamine
T7051	4845-4847	IN	denotes	to
T7052	4848-4857	NN	denotes	glutamate
T7053	4858-4859	-LRB-	denotes	(
T7054	4859-4863	DT	denotes	both
T7055	4864-4875	JJ	denotes	fundamental
T7056	4876-4878	TO	denotes	to
T7057	4879-4887	VB	denotes	maintain
T7058	4888-4891	DT	denotes	the
T7060	4892-4902	JJ	denotes	electrical
T7059	4903-4911	NN	denotes	activity
T7061	4912-4914	IN	denotes	in
T7062	4915-4918	DT	denotes	the
T7063	4919-4922	NN	denotes	CNS
T7064	4922-4923	-RRB-	denotes	)
T7035	4924-4932	VBZ	denotes	consumes
T7066	4933-4936	DT	denotes	the
T7068	4937-4941	JJ	denotes	vast
T7067	4942-4950	NN	denotes	majority
T7069	4951-4953	IN	denotes	of
T7070	4954-4957	DT	denotes	the
T7071	4958-4964	NN	denotes	energy
T7072	4965-4973	VBN	denotes	produced
T7073	4974-4976	IN	denotes	by
T7074	4977-4980	DT	denotes	the
T7075	4981-4984	NN	denotes	CNS
T7076	4985-4986	-LRB-	denotes	[
T7077	4986-4988	CD	denotes	45
T7078	4988-4989	SYM	denotes	–
T7079	4989-4991	CD	denotes	47
T7080	4991-4992	-RRB-	denotes	]
T7081	4992-4994	,	denotes	,
T7082	4994-4998	DT	denotes	this
T7083	4999-5005	RB	denotes	likely
T7065	5006-5015	VBZ	denotes	underlies
T7084	5016-5019	DT	denotes	the
T7085	5020-5031	NN	denotes	suppression
T7086	5032-5034	IN	denotes	of
T7087	5035-5038	DT	denotes	the
T7089	5039-5059	JJ	denotes	electrophysiological
T7090	5060-5066	NN	denotes	output
T7088	5067-5076	NNS	denotes	responses
T7091	5077-5079	IN	denotes	of
T7092	5080-5087	JJ	denotes	retinal
T7093	5088-5095	NNS	denotes	neurons
T7094	5096-5097	-LRB-	denotes	(
T7095	5097-5103	NN	denotes	Figure
T7096	5104-5105	CD	denotes	8
T7097	5105-5106	-RRB-	denotes	)
T7098	5106-5107	.	denotes	.
T7099	5107-5300	sentence	denotes	Moreover, deficits in HKI may lead to intracellular hyperglycemia in the CNS, promote sorbitol-induced osmotic stress, and compromise further the ATPase-dependent Na+/K+ pump activity [48–50].
T7100	5108-5116	RB	denotes	Moreover
T7102	5116-5118	,	denotes	,
T7103	5118-5126	NNS	denotes	deficits
T7104	5127-5129	IN	denotes	in
T7105	5130-5133	NN	denotes	HKI
T7106	5134-5137	MD	denotes	may
T7101	5138-5142	VB	denotes	lead
T7107	5143-5145	IN	denotes	to
T7108	5146-5159	JJ	denotes	intracellular
T7109	5160-5173	NN	denotes	hyperglycemia
T7110	5174-5176	IN	denotes	in
T7111	5177-5180	DT	denotes	the
T7112	5181-5184	NN	denotes	CNS
T7113	5184-5186	,	denotes	,
T7114	5186-5193	VB	denotes	promote
T7115	5194-5202	NN	denotes	sorbitol
T7117	5202-5203	HYPH	denotes	-
T7116	5203-5210	VBN	denotes	induced
T7119	5211-5218	JJ	denotes	osmotic
T7118	5219-5225	NN	denotes	stress
T7120	5225-5227	,	denotes	,
T7121	5227-5230	CC	denotes	and
T7122	5231-5241	VB	denotes	compromise
T7123	5242-5249	RB	denotes	further
T7124	5250-5253	DT	denotes	the
T7126	5254-5260	NN	denotes	ATPase
T7128	5260-5261	HYPH	denotes	-
T7127	5261-5270	JJ	denotes	dependent
T7129	5271-5274	NN	denotes	Na+
T7131	5274-5275	HYPH	denotes	/
T7130	5275-5277	NN	denotes	K+
T7132	5278-5282	NN	denotes	pump
T7125	5283-5291	NN	denotes	activity
T7133	5292-5293	-LRB-	denotes	[
T7134	5293-5295	CD	denotes	48
T7135	5295-5296	SYM	denotes	–
T7136	5296-5298	CD	denotes	50
T7137	5298-5299	-RRB-	denotes	]
T7138	5299-5300	.	denotes	.
T7139	5300-5404	sentence	denotes	This may be exacerbated by a decrease of ATP, since the activity of HKI is also stimulated by ATP [51].
T7140	5301-5305	DT	denotes	This
T7142	5306-5309	MD	denotes	may
T7143	5310-5312	VB	denotes	be
T7141	5313-5324	VBN	denotes	exacerbated
T7144	5325-5327	IN	denotes	by
T7145	5328-5329	DT	denotes	a
T7146	5330-5338	NN	denotes	decrease
T7147	5339-5341	IN	denotes	of
T7148	5342-5345	NN	denotes	ATP
T7149	5345-5347	,	denotes	,
T7150	5347-5352	IN	denotes	since
T7152	5353-5356	DT	denotes	the
T7153	5357-5365	NN	denotes	activity
T7154	5366-5368	IN	denotes	of
T7155	5369-5372	NN	denotes	HKI
T7156	5373-5375	VBZ	denotes	is
T7157	5376-5380	RB	denotes	also
T7151	5381-5391	VBN	denotes	stimulated
T7158	5392-5394	IN	denotes	by
T7159	5395-5398	NN	denotes	ATP
T7160	5399-5400	-LRB-	denotes	[
T7161	5400-5402	CD	denotes	51
T7162	5402-5403	-RRB-	denotes	]
T7163	5403-5404	.	denotes	.
T7164	5404-5585	sentence	denotes	The cumulative effects of a reduction in ATP and intracellular hyperglycemia are known to act synergistically and modulate the electrophysiological properties of neuronal activity.
T7165	5405-5408	DT	denotes	The
T7167	5409-5419	JJ	denotes	cumulative
T7166	5420-5427	NNS	denotes	effects
T7169	5428-5430	IN	denotes	of
T7170	5431-5432	DT	denotes	a
T7171	5433-5442	NN	denotes	reduction
T7172	5443-5445	IN	denotes	in
T7173	5446-5449	NN	denotes	ATP
T7174	5450-5453	CC	denotes	and
T7175	5454-5467	JJ	denotes	intracellular
T7176	5468-5481	NN	denotes	hyperglycemia
T7177	5482-5485	VBP	denotes	are
T7168	5486-5491	VBN	denotes	known
T7178	5492-5494	TO	denotes	to
T7179	5495-5498	VB	denotes	act
T7180	5499-5514	RB	denotes	synergistically
T7181	5515-5518	CC	denotes	and
T7182	5519-5527	VB	denotes	modulate
T7183	5528-5531	DT	denotes	the
T7185	5532-5552	JJ	denotes	electrophysiological
T7184	5553-5563	NNS	denotes	properties
T7186	5564-5566	IN	denotes	of
T7187	5567-5575	JJ	denotes	neuronal
T7188	5576-5584	NN	denotes	activity
T7189	5584-5585	.	denotes	.
T7190	5585-5679	sentence	denotes	Figure 9 integrates in a model these variables and implications of the data presented herein.
T7191	5586-5592	NN	denotes	Figure
T7193	5593-5594	CD	denotes	9
T7192	5595-5605	VBZ	denotes	integrates
T7194	5606-5608	IN	denotes	in
T7195	5609-5610	DT	denotes	a
T7196	5611-5616	NN	denotes	model
T7197	5617-5622	DT	denotes	these
T7198	5623-5632	NNS	denotes	variables
T7199	5633-5636	CC	denotes	and
T7200	5637-5649	NNS	denotes	implications
T7201	5650-5652	IN	denotes	of
T7202	5653-5656	DT	denotes	the
T7203	5657-5661	NNS	denotes	data
T7204	5662-5671	VBN	denotes	presented
T7205	5672-5678	RB	denotes	herein
T7206	5678-5679	.	denotes	.
T7207	5679-5842	sentence	denotes	Still, other bona fide RanBP2 partners previously identified and described in the Introduction also become strong candidates to play a role in energy homeostasis.
T7208	5680-5685	RB	denotes	Still
T7210	5685-5687	,	denotes	,
T7211	5687-5692	JJ	denotes	other
T7213	5693-5697	FW	denotes	bona
T7214	5698-5702	FW	denotes	fide
T7215	5703-5709	NN	denotes	RanBP2
T7212	5710-5718	NNS	denotes	partners
T7216	5719-5729	RB	denotes	previously
T7217	5730-5740	VBN	denotes	identified
T7218	5741-5744	CC	denotes	and
T7219	5745-5754	VBN	denotes	described
T7220	5755-5757	IN	denotes	in
T7221	5758-5761	DT	denotes	the
T7222	5762-5774	NN	denotes	Introduction
T7223	5775-5779	RB	denotes	also
T7209	5780-5786	VBP	denotes	become
T7224	5787-5793	JJ	denotes	strong
T7225	5794-5804	NNS	denotes	candidates
T7226	5805-5807	TO	denotes	to
T7227	5808-5812	VB	denotes	play
T7228	5813-5814	DT	denotes	a
T7229	5815-5819	NN	denotes	role
T7230	5820-5822	IN	denotes	in
T7231	5823-5829	NN	denotes	energy
T7232	5830-5841	NN	denotes	homeostasis
T7233	5841-5842	.	denotes	.
T7234	5842-6283	sentence	denotes	For example, the unfolding and chaperone activity of components of the 19S cap of the proteasome may be modulated by the CLD of RanBP2 [14] and contribute to the selective HKI (and other substrates) degradation [43], while association of nuclear import receptor, importin-β with the Ran-binding domains of RanBP2 [10,11], may mediate the nuclear translocation of multifunctional substrates, such as glyceraldehyde-3-phosphate dehydrogenase.
T7235	5843-5846	IN	denotes	For
T7237	5847-5854	NN	denotes	example
T7238	5854-5856	,	denotes	,
T7239	5856-5859	DT	denotes	the
T7241	5860-5869	JJ	denotes	unfolding
T7243	5870-5873	CC	denotes	and
T7242	5874-5883	NN	denotes	chaperone
T7240	5884-5892	NN	denotes	activity
T7244	5893-5895	IN	denotes	of
T7245	5896-5906	NNS	denotes	components
T7246	5907-5909	IN	denotes	of
T7247	5910-5913	DT	denotes	the
T7249	5914-5917	NN	denotes	19S
T7248	5918-5921	NN	denotes	cap
T7250	5922-5924	IN	denotes	of
T7251	5925-5928	DT	denotes	the
T7252	5929-5939	NN	denotes	proteasome
T7253	5940-5943	MD	denotes	may
T7254	5944-5946	VB	denotes	be
T7236	5947-5956	VBN	denotes	modulated
T7255	5957-5959	IN	denotes	by
T7256	5960-5963	DT	denotes	the
T7257	5964-5967	NN	denotes	CLD
T7258	5968-5970	IN	denotes	of
T7259	5971-5977	NN	denotes	RanBP2
T7260	5978-5979	-LRB-	denotes	[
T7261	5979-5981	CD	denotes	14
T7262	5981-5982	-RRB-	denotes	]
T7263	5983-5986	CC	denotes	and
T7264	5987-5997	VB	denotes	contribute
T7265	5998-6000	IN	denotes	to
T7266	6001-6004	DT	denotes	the
T7268	6005-6014	JJ	denotes	selective
T7269	6015-6018	NN	denotes	HKI
T7270	6019-6020	-LRB-	denotes	(
T7271	6020-6023	CC	denotes	and
T7272	6024-6029	JJ	denotes	other
T7273	6030-6040	NNS	denotes	substrates
T7274	6040-6041	-RRB-	denotes	)
T7267	6042-6053	NN	denotes	degradation
T7275	6054-6055	-LRB-	denotes	[
T7276	6055-6057	CD	denotes	43
T7277	6057-6058	-RRB-	denotes	]
T7278	6058-6060	,	denotes	,
T7279	6060-6065	IN	denotes	while
T7281	6066-6077	NN	denotes	association
T7282	6078-6080	IN	denotes	of
T7283	6081-6088	JJ	denotes	nuclear
T7285	6089-6095	NN	denotes	import
T7284	6096-6104	NN	denotes	receptor
T7286	6104-6106	,	denotes	,
T7287	6106-6114	NN	denotes	importin
T7289	6114-6115	HYPH	denotes	-
T7288	6115-6116	NN	denotes	β
T7290	6117-6121	IN	denotes	with
T7291	6122-6125	DT	denotes	the
T7293	6126-6129	NN	denotes	Ran
T7295	6129-6130	HYPH	denotes	-
T7294	6130-6137	VBG	denotes	binding
T7292	6138-6145	NNS	denotes	domains
T7296	6146-6148	IN	denotes	of
T7297	6149-6155	NN	denotes	RanBP2
T7298	6156-6157	-LRB-	denotes	[
T7300	6157-6159	CD	denotes	10
T7301	6159-6160	,	denotes	,
T7299	6160-6162	CD	denotes	11
T7302	6162-6163	-RRB-	denotes	]
T7303	6163-6165	,	denotes	,
T7304	6165-6168	MD	denotes	may
T7280	6169-6176	VB	denotes	mediate
T7305	6177-6180	DT	denotes	the
T7307	6181-6188	JJ	denotes	nuclear
T7306	6189-6202	NN	denotes	translocation
T7308	6203-6205	IN	denotes	of
T7309	6206-6221	JJ	denotes	multifunctional
T7310	6222-6232	NNS	denotes	substrates
T7311	6232-6234	,	denotes	,
T7312	6234-6238	JJ	denotes	such
T7313	6239-6241	IN	denotes	as
T7314	6242-6256	NN	denotes	glyceraldehyde
T7316	6256-6257	HYPH	denotes	-
T7317	6257-6258	CD	denotes	3
T7318	6258-6259	HYPH	denotes	-
T7315	6259-6268	NN	denotes	phosphate
T7319	6269-6282	NN	denotes	dehydrogenase
T7320	6282-6283	.	denotes	.
T7321	6283-6459	sentence	denotes	This trafficking process is selectively inhibited by the neuroprotective drug, R-(-)-deprenyl and derivates thereof, and are often employed to treat Parkinson disease [52–57].
T7322	6284-6288	DT	denotes	This
T7324	6289-6300	NN	denotes	trafficking
T7323	6301-6308	NN	denotes	process
T7326	6309-6311	VBZ	denotes	is
T7327	6312-6323	RB	denotes	selectively
T7325	6324-6333	VBN	denotes	inhibited
T7328	6334-6336	IN	denotes	by
T7329	6337-6340	DT	denotes	the
T7331	6341-6356	JJ	denotes	neuroprotective
T7330	6357-6361	NN	denotes	drug
T7332	6361-6363	,	denotes	,
T7333	6363-6364	NN	denotes	R
T7335	6364-6365	HYPH	denotes	-
T7336	6365-6366	-LRB-	denotes	(
T7337	6366-6367	SYM	denotes	-
T7338	6367-6368	-RRB-	denotes	)
T7339	6368-6369	HYPH	denotes	-
T7334	6369-6377	NN	denotes	deprenyl
T7340	6378-6381	CC	denotes	and
T7341	6382-6391	VBZ	denotes	derivates
T7342	6392-6399	RB	denotes	thereof
T7343	6399-6401	,	denotes	,
T7344	6401-6404	CC	denotes	and
T7345	6405-6408	VBP	denotes	are
T7347	6409-6414	RB	denotes	often
T7346	6415-6423	VBN	denotes	employed
T7348	6424-6426	TO	denotes	to
T7349	6427-6432	VB	denotes	treat
T7350	6433-6442	NNP	denotes	Parkinson
T7351	6443-6450	NN	denotes	disease
T7352	6451-6452	-LRB-	denotes	[
T7353	6452-6454	CD	denotes	52
T7354	6454-6455	SYM	denotes	–
T7355	6455-6457	CD	denotes	57
T7356	6457-6458	-RRB-	denotes	]
T7357	6458-6459	.	denotes	.
T7358	6459-6803	sentence	denotes	Hence, RanBP2 and its partners emerge as key players and target genes in mediating neuropathophysiological mechanisms implicated in various genetic and environmental lesions to the CNS, as in patients with Parkinson, diabetes with insulin-resistance, and other neuropathies and neurodegenerative diseases, often linked to aging manifestations.
T7359	6460-6465	RB	denotes	Hence
T7361	6465-6467	,	denotes	,
T7362	6467-6473	NN	denotes	RanBP2
T7363	6474-6477	CC	denotes	and
T7364	6478-6481	PRP$	denotes	its
T7365	6482-6490	NNS	denotes	partners
T7360	6491-6497	VBP	denotes	emerge
T7366	6498-6500	IN	denotes	as
T7367	6501-6504	JJ	denotes	key
T7368	6505-6512	NNS	denotes	players
T7369	6513-6516	CC	denotes	and
T7370	6517-6523	NN	denotes	target
T7371	6524-6529	NNS	denotes	genes
T7372	6530-6532	IN	denotes	in
T7373	6533-6542	VBG	denotes	mediating
T7374	6543-6566	JJ	denotes	neuropathophysiological
T7375	6567-6577	NNS	denotes	mechanisms
T7376	6578-6588	VBN	denotes	implicated
T7377	6589-6591	IN	denotes	in
T7378	6592-6599	JJ	denotes	various
T7380	6600-6607	JJ	denotes	genetic
T7381	6608-6611	CC	denotes	and
T7382	6612-6625	JJ	denotes	environmental
T7379	6626-6633	NNS	denotes	lesions
T7383	6634-6636	IN	denotes	to
T7384	6637-6640	DT	denotes	the
T7385	6641-6644	NN	denotes	CNS
T7386	6644-6646	,	denotes	,
T7387	6646-6648	IN	denotes	as
T7388	6649-6651	IN	denotes	in
T7389	6652-6660	NNS	denotes	patients
T7390	6661-6665	IN	denotes	with
T7391	6666-6675	NNP	denotes	Parkinson
T7392	6675-6677	,	denotes	,
T7393	6677-6685	NN	denotes	diabetes
T7394	6686-6690	IN	denotes	with
T7395	6691-6698	NN	denotes	insulin
T7397	6698-6699	HYPH	denotes	-
T7396	6699-6709	NN	denotes	resistance
T7398	6709-6711	,	denotes	,
T7399	6711-6714	CC	denotes	and
T7400	6715-6720	JJ	denotes	other
T7401	6721-6733	NNS	denotes	neuropathies
T7402	6734-6737	CC	denotes	and
T7403	6738-6755	JJ	denotes	neurodegenerative
T7404	6756-6764	NNS	denotes	diseases
T7405	6764-6766	,	denotes	,
T7406	6766-6771	RB	denotes	often
T7407	6772-6778	VBN	denotes	linked
T7408	6779-6781	IN	denotes	to
T7409	6782-6787	NN	denotes	aging
T7410	6788-6802	NNS	denotes	manifestations
T7411	6802-6803	.	denotes	.
T7412	6803-7037	sentence	denotes	To this effect, the RanBP2 mouse model will serve as a unique genetic tool to probe selective, multiple and novel pathways, which may have not been anticipated to be linked to metabolic processes and allied pathophysiological states.
T7413	6804-6806	IN	denotes	To
T7415	6807-6811	DT	denotes	this
T7416	6812-6818	NN	denotes	effect
T7417	6818-6820	,	denotes	,
T7418	6820-6823	DT	denotes	the
T7420	6824-6830	NN	denotes	RanBP2
T7421	6831-6836	NN	denotes	mouse
T7419	6837-6842	NN	denotes	model
T7422	6843-6847	MD	denotes	will
T7414	6848-6853	VB	denotes	serve
T7423	6854-6856	IN	denotes	as
T7424	6857-6858	DT	denotes	a
T7426	6859-6865	JJ	denotes	unique
T7427	6866-6873	JJ	denotes	genetic
T7425	6874-6878	NN	denotes	tool
T7428	6879-6881	TO	denotes	to
T7429	6882-6887	VB	denotes	probe
T7430	6888-6897	JJ	denotes	selective
T7432	6897-6899	,	denotes	,
T7433	6899-6907	JJ	denotes	multiple
T7434	6908-6911	CC	denotes	and
T7435	6912-6917	JJ	denotes	novel
T7431	6918-6926	NNS	denotes	pathways
T7436	6926-6928	,	denotes	,
T7437	6928-6933	WDT	denotes	which
T7439	6934-6937	MD	denotes	may
T7440	6938-6942	VB	denotes	have
T7441	6943-6946	RB	denotes	not
T7442	6947-6951	VBN	denotes	been
T7438	6952-6963	VBN	denotes	anticipated
T7443	6964-6966	TO	denotes	to
T7445	6967-6969	VB	denotes	be
T7444	6970-6976	VBN	denotes	linked
T7446	6977-6979	IN	denotes	to
T7447	6980-6989	JJ	denotes	metabolic
T7448	6990-6999	NNS	denotes	processes
T7449	7000-7003	CC	denotes	and
T7450	7004-7010	VBN	denotes	allied
T7452	7011-7029	JJ	denotes	pathophysiological
T7451	7030-7036	NNS	denotes	states
T7453	7036-7037	.	denotes	.
T7454	7037-8533	sentence	denotes	Figure 9 Model Depicting a Role of RanBP2 and Some of Its Partners in Metabolic and Neuronal Function RanBP2 interacts with Cox11 and HKI and the triad is in equilibrium under normal physiological conditions. RanBP2 prevents the inhibition of HKI by Cox11 and its degradation. The ultimate effect of RanBP2 on its partners is the stimulation of the glycolytic pathway and production of ATP. The glycolytic pathway is critical to fuel the constitutive Na+/K+-ATPase pump to maintain the dark current between the inner and outer segment compartments of photosensory neurons. A deficit (haploinsufficiency) in RanBP2 disturbs the equilibrium between RanBP2, HKI, and Cox11. This pathophysiological event promotes the destabilization and degradation of HKI and a decrease in ATP production required to maintain the depolarization state neurons, and, hence, a reduction in the response of receptoral and postreceptoral neurons. A reduction in ATP levels also negatively modulates HKI activity/level. Decreased levels of HKI promote intracellular hyperglycemia and activate stress kinases, which modulate negatively the Na+/K+-ATPase pump by phosphorylation. Pathophysiological pathways promoted by RanBP2 haploinsufficiency are represented by dash lines. RIS, rod inner segment; ROS, rod outer segment. Finally, RanBP2 appears to join other nucleoporins, such as Nup96 [58], in novel physiological functions that are vital for complex organisms and that were not anticipated from cell-based studies.
T7455	7038-8344	RB	denotes	Figure 9 Model Depicting a Role of RanBP2 and Some of Its Partners in Metabolic and Neuronal Function RanBP2 interacts with Cox11 and HKI and the triad is in equilibrium under normal physiological conditions. RanBP2 prevents the inhibition of HKI by Cox11 and its degradation. The ultimate effect of RanBP2 on its partners is the stimulation of the glycolytic pathway and production of ATP. The glycolytic pathway is critical to fuel the constitutive Na+/K+-ATPase pump to maintain the dark current between the inner and outer segment compartments of photosensory neurons. A deficit (haploinsufficiency) in RanBP2 disturbs the equilibrium between RanBP2, HKI, and Cox11. This pathophysiological event promotes the destabilization and degradation of HKI and a decrease in ATP production required to maintain the depolarization state neurons, and, hence, a reduction in the response of receptoral and postreceptoral neurons. A reduction in ATP levels also negatively modulates HKI activity/level. Decreased levels of HKI promote intracellular hyperglycemia and activate stress kinases, which modulate negatively the Na+/K+-ATPase pump by phosphorylation. Pathophysiological pathways promoted by RanBP2 haploinsufficiency are represented by dash lines. RIS, rod inner segment; ROS, rod outer segment. Finally
T14525	7048-7053	NN	denotes	Model
T14526	7054-7063	VBG	denotes	Depicting
T14527	7064-7065	DT	denotes	a
T14528	7066-7070	NN	denotes	Role
T14529	7071-7073	IN	denotes	of
T14530	7074-7080	NN	denotes	RanBP2
T14531	7081-7084	CC	denotes	and
T14532	7085-7089	DT	denotes	Some
T14533	7090-7092	IN	denotes	of
T14534	7093-7096	PRP$	denotes	Its
T14535	7097-7105	NNS	denotes	Partners
T14536	7106-7108	IN	denotes	in
T14537	7109-7118	JJ	denotes	Metabolic
T14539	7119-7122	CC	denotes	and
T14540	7123-7131	JJ	denotes	Neuronal
T14538	7132-7140	NN	denotes	Function
T14541	7140-7247	sentence	denotes	RanBP2 interacts with Cox11 and HKI and the triad is in equilibrium under normal physiological conditions.
T14542	7141-7147	NN	denotes	RanBP2
T14543	7148-7157	VBZ	denotes	interacts
T14544	7158-7162	IN	denotes	with
T14545	7163-7168	NN	denotes	Cox11
T14546	7169-7172	CC	denotes	and
T14547	7173-7176	NN	denotes	HKI
T14548	7177-7180	CC	denotes	and
T14549	7181-7184	DT	denotes	the
T14550	7185-7190	NN	denotes	triad
T14551	7191-7193	VBZ	denotes	is
T14552	7194-7196	IN	denotes	in
T14553	7197-7208	NN	denotes	equilibrium
T14554	7209-7214	IN	denotes	under
T14555	7215-7221	JJ	denotes	normal
T14557	7222-7235	JJ	denotes	physiological
T14556	7236-7246	NNS	denotes	conditions
T14558	7246-7247	.	denotes	.
T14559	7247-7315	sentence	denotes	RanBP2 prevents the inhibition of HKI by Cox11 and its degradation.
T14560	7248-7254	NN	denotes	RanBP2
T14561	7255-7263	VBZ	denotes	prevents
T14562	7264-7267	DT	denotes	the
T14563	7268-7278	NN	denotes	inhibition
T14564	7279-7281	IN	denotes	of
T14565	7282-7285	NN	denotes	HKI
T14566	7286-7288	IN	denotes	by
T14567	7289-7294	NN	denotes	Cox11
T14568	7295-7298	CC	denotes	and
T14569	7299-7302	PRP$	denotes	its
T14570	7303-7314	NN	denotes	degradation
T14571	7314-7315	.	denotes	.
T14572	7315-7429	sentence	denotes	The ultimate effect of RanBP2 on its partners is the stimulation of the glycolytic pathway and production of ATP.
T14573	7316-7319	DT	denotes	The
T14575	7320-7328	JJ	denotes	ultimate
T14574	7329-7335	NN	denotes	effect
T14577	7336-7338	IN	denotes	of
T14578	7339-7345	NN	denotes	RanBP2
T14579	7346-7348	IN	denotes	on
T14580	7349-7352	PRP$	denotes	its
T14581	7353-7361	NNS	denotes	partners
T14576	7362-7364	VBZ	denotes	is
T14582	7365-7368	DT	denotes	the
T14583	7369-7380	NN	denotes	stimulation
T14584	7381-7383	IN	denotes	of
T14585	7384-7387	DT	denotes	the
T14587	7388-7398	JJ	denotes	glycolytic
T14586	7399-7406	NN	denotes	pathway
T14588	7407-7410	CC	denotes	and
T14589	7411-7421	NN	denotes	production
T14590	7422-7424	IN	denotes	of
T14591	7425-7428	NN	denotes	ATP
T14592	7428-7429	.	denotes	.
T14593	7429-7611	sentence	denotes	The glycolytic pathway is critical to fuel the constitutive Na+/K+-ATPase pump to maintain the dark current between the inner and outer segment compartments of photosensory neurons.
T14594	7430-7433	DT	denotes	The
T14596	7434-7444	JJ	denotes	glycolytic
T14595	7445-7452	NN	denotes	pathway
T14597	7453-7455	VBZ	denotes	is
T14598	7456-7464	JJ	denotes	critical
T14599	7465-7467	TO	denotes	to
T14600	7468-7472	VB	denotes	fuel
T14601	7473-7476	DT	denotes	the
T14603	7477-7489	JJ	denotes	constitutive
T14604	7490-7493	NN	denotes	Na+
T14606	7493-7494	SYM	denotes	/
T14605	7494-7496	NN	denotes	K+
T14608	7496-7497	HYPH	denotes	-
T14607	7497-7503	NN	denotes	ATPase
T14602	7504-7508	NN	denotes	pump
T14609	7509-7511	TO	denotes	to
T14610	7512-7520	VB	denotes	maintain
T14611	7521-7524	DT	denotes	the
T14613	7525-7529	JJ	denotes	dark
T14612	7530-7537	NN	denotes	current
T14614	7538-7545	IN	denotes	between
T14615	7546-7549	DT	denotes	the
T14617	7550-7555	JJ	denotes	inner
T14618	7556-7559	CC	denotes	and
T14619	7560-7565	JJ	denotes	outer
T14620	7566-7573	NN	denotes	segment
T14616	7574-7586	NNS	denotes	compartments
T14621	7587-7589	IN	denotes	of
T14622	7590-7602	JJ	denotes	photosensory
T14623	7603-7610	NNS	denotes	neurons
T14624	7610-7611	.	denotes	.
T14625	7611-7709	sentence	denotes	A deficit (haploinsufficiency) in RanBP2 disturbs the equilibrium between RanBP2, HKI, and Cox11.
T14626	7612-7613	DT	denotes	A
T14627	7614-7621	NN	denotes	deficit
T14629	7622-7623	-LRB-	denotes	(
T14630	7623-7641	NN	denotes	haploinsufficiency
T14631	7641-7642	-RRB-	denotes	)
T14632	7643-7645	IN	denotes	in
T14633	7646-7652	NN	denotes	RanBP2
T14628	7653-7661	VBZ	denotes	disturbs
T14634	7662-7665	DT	denotes	the
T14635	7666-7677	NN	denotes	equilibrium
T14636	7678-7685	IN	denotes	between
T14637	7686-7692	NN	denotes	RanBP2
T14638	7692-7694	,	denotes	,
T14639	7694-7697	NN	denotes	HKI
T14640	7697-7699	,	denotes	,
T14641	7699-7702	CC	denotes	and
T14642	7703-7708	NN	denotes	Cox11
T14643	7708-7709	.	denotes	.
T14644	7709-7961	sentence	denotes	This pathophysiological event promotes the destabilization and degradation of HKI and a decrease in ATP production required to maintain the depolarization state neurons, and, hence, a reduction in the response of receptoral and postreceptoral neurons.
T14645	7710-7714	DT	denotes	This
T14647	7715-7733	JJ	denotes	pathophysiological
T14646	7734-7739	NN	denotes	event
T14648	7740-7748	VBZ	denotes	promotes
T14649	7749-7752	DT	denotes	the
T14650	7753-7768	NN	denotes	destabilization
T14651	7769-7772	CC	denotes	and
T14652	7773-7784	NN	denotes	degradation
T14653	7785-7787	IN	denotes	of
T14654	7788-7791	NN	denotes	HKI
T14655	7792-7795	CC	denotes	and
T14656	7796-7797	DT	denotes	a
T14657	7798-7806	NN	denotes	decrease
T14658	7807-7809	IN	denotes	in
T14659	7810-7813	NN	denotes	ATP
T14660	7814-7824	NN	denotes	production
T14661	7825-7833	VBN	denotes	required
T14662	7834-7836	TO	denotes	to
T14663	7837-7845	VB	denotes	maintain
T14664	7846-7849	DT	denotes	the
T14666	7850-7864	NN	denotes	depolarization
T14667	7865-7870	NN	denotes	state
T14665	7871-7878	NNS	denotes	neurons
T14668	7878-7880	,	denotes	,
T14669	7880-7883	CC	denotes	and
T14670	7883-7885	,	denotes	,
T14671	7885-7890	RB	denotes	hence
T14673	7890-7892	,	denotes	,
T14674	7892-7893	DT	denotes	a
T14672	7894-7903	NN	denotes	reduction
T14675	7904-7906	IN	denotes	in
T14676	7907-7910	DT	denotes	the
T14677	7911-7919	NN	denotes	response
T14678	7920-7922	IN	denotes	of
T14679	7923-7933	JJ	denotes	receptoral
T14681	7934-7937	CC	denotes	and
T14682	7938-7952	JJ	denotes	postreceptoral
T14680	7953-7960	NNS	denotes	neurons
T14683	7960-7961	.	denotes	.
T14684	7961-8033	sentence	denotes	A reduction in ATP levels also negatively modulates HKI activity/level.
T14685	7962-7963	DT	denotes	A
T14686	7964-7973	NN	denotes	reduction
T14688	7974-7976	IN	denotes	in
T14689	7977-7980	NN	denotes	ATP
T14690	7981-7987	NNS	denotes	levels
T14691	7988-7992	RB	denotes	also
T14692	7993-8003	RB	denotes	negatively
T14687	8004-8013	VBZ	denotes	modulates
T14693	8014-8017	NN	denotes	HKI
T14694	8018-8026	NN	denotes	activity
T14695	8026-8027	SYM	denotes	/
T14696	8027-8032	NN	denotes	level
T14697	8032-8033	.	denotes	.
T14698	8033-8191	sentence	denotes	Decreased levels of HKI promote intracellular hyperglycemia and activate stress kinases, which modulate negatively the Na+/K+-ATPase pump by phosphorylation.
T14699	8034-8043	VBN	denotes	Decreased
T14700	8044-8050	NNS	denotes	levels
T14702	8051-8053	IN	denotes	of
T14703	8054-8057	NN	denotes	HKI
T14701	8058-8065	VBP	denotes	promote
T14704	8066-8079	JJ	denotes	intracellular
T14705	8080-8093	NN	denotes	hyperglycemia
T14706	8094-8097	CC	denotes	and
T14707	8098-8106	VBP	denotes	activate
T14708	8107-8113	NN	denotes	stress
T14709	8114-8121	NNS	denotes	kinases
T14710	8121-8123	,	denotes	,
T14711	8123-8128	WDT	denotes	which
T14712	8129-8137	VBP	denotes	modulate
T14713	8138-8148	RB	denotes	negatively
T14714	8149-8152	DT	denotes	the
T14716	8153-8156	NN	denotes	Na+
T14718	8156-8157	HYPH	denotes	/
T14717	8157-8159	NN	denotes	K+
T14720	8159-8160	HYPH	denotes	-
T14719	8160-8166	NN	denotes	ATPase
T14715	8167-8171	NN	denotes	pump
T14721	8172-8174	IN	denotes	by
T14722	8175-8190	NN	denotes	phosphorylation
T14723	8190-8191	.	denotes	.
T14724	8191-8288	sentence	denotes	Pathophysiological pathways promoted by RanBP2 haploinsufficiency are represented by dash lines.
T14725	8192-8210	JJ	denotes	Pathophysiological
T14726	8211-8219	NNS	denotes	pathways
T14728	8220-8228	VBN	denotes	promoted
T14729	8229-8231	IN	denotes	by
T14730	8232-8238	NN	denotes	RanBP2
T14731	8239-8257	NN	denotes	haploinsufficiency
T14732	8258-8261	VBP	denotes	are
T14727	8262-8273	VBN	denotes	represented
T14733	8274-8276	IN	denotes	by
T14734	8277-8281	NN	denotes	dash
T14735	8282-8287	NNS	denotes	lines
T14736	8287-8288	.	denotes	.
T14737	8288-8336	sentence	denotes	RIS, rod inner segment; ROS, rod outer segment.
T14738	8289-8292	NN	denotes	RIS
T14739	8292-8294	,	denotes	,
T14740	8294-8297	NN	denotes	rod
T14742	8298-8303	JJ	denotes	inner
T14741	8304-8311	NN	denotes	segment
T14743	8311-8312	:	denotes	;
T14744	8313-8316	NN	denotes	ROS
T14745	8316-8318	,	denotes	,
T14746	8318-8321	NN	denotes	rod
T14748	8322-8327	JJ	denotes	outer
T14747	8328-8335	NN	denotes	segment
T14749	8335-8336	.	denotes	.
T7457	8344-8346	,	denotes	,
T7458	8346-8352	NN	denotes	RanBP2
T7456	8353-8360	VBZ	denotes	appears
T7459	8361-8363	TO	denotes	to
T7460	8364-8368	VB	denotes	join
T7461	8369-8374	JJ	denotes	other
T7462	8375-8387	NNS	denotes	nucleoporins
T7463	8387-8389	,	denotes	,
T7464	8389-8393	JJ	denotes	such
T7465	8394-8396	IN	denotes	as
T7466	8397-8402	NN	denotes	Nup96
T7467	8403-8404	-LRB-	denotes	[
T7468	8404-8406	CD	denotes	58
T7469	8406-8407	-RRB-	denotes	]
T7470	8407-8409	,	denotes	,
T7471	8409-8411	IN	denotes	in
T7472	8412-8417	JJ	denotes	novel
T7474	8418-8431	JJ	denotes	physiological
T7473	8432-8441	NNS	denotes	functions
T7475	8442-8446	WDT	denotes	that
T7476	8447-8450	VBP	denotes	are
T7477	8451-8456	JJ	denotes	vital
T7478	8457-8460	IN	denotes	for
T7479	8461-8468	JJ	denotes	complex
T7480	8469-8478	NNS	denotes	organisms
T7481	8479-8482	CC	denotes	and
T7482	8483-8487	WDT	denotes	that
T7484	8488-8492	VBD	denotes	were
T7485	8493-8496	RB	denotes	not
T7483	8497-8508	VBN	denotes	anticipated
T7486	8509-8513	IN	denotes	from
T7487	8514-8518	NN	denotes	cell
T7489	8518-8519	HYPH	denotes	-
T7488	8519-8524	VBN	denotes	based
T7490	8525-8532	NNS	denotes	studies
T7491	8532-8533	.	denotes	.
T7492	8533-8772	sentence	denotes	The reduced expression of these proteins in whole-animal models generates phenotypes that are tissue-restricted and more importantly, do not seem to recapitulate phenotypes observed with knockdown experiments in cell-based culture assays.
T7493	8534-8537	DT	denotes	The
T7495	8538-8545	VBN	denotes	reduced
T7494	8546-8556	NN	denotes	expression
T7497	8557-8559	IN	denotes	of
T7498	8560-8565	DT	denotes	these
T7499	8566-8574	NN	denotes	proteins
T7500	8575-8577	IN	denotes	in
T7501	8578-8583	JJ	denotes	whole
T7503	8583-8584	HYPH	denotes	-
T7502	8584-8590	NN	denotes	animal
T7504	8591-8597	NNS	denotes	models
T7496	8598-8607	VBZ	denotes	generates
T7505	8608-8618	NNS	denotes	phenotypes
T7506	8619-8623	WDT	denotes	that
T7507	8624-8627	VBP	denotes	are
T7508	8628-8634	NN	denotes	tissue
T7510	8634-8635	HYPH	denotes	-
T7509	8635-8645	JJ	denotes	restricted
T7511	8646-8649	CC	denotes	and
T7512	8650-8654	RBR	denotes	more
T7513	8655-8666	RB	denotes	importantly
T7515	8666-8668	,	denotes	,
T7516	8668-8670	VBP	denotes	do
T7517	8671-8674	RB	denotes	not
T7514	8675-8679	VB	denotes	seem
T7518	8680-8682	TO	denotes	to
T7519	8683-8695	VB	denotes	recapitulate
T7520	8696-8706	NNS	denotes	phenotypes
T7521	8707-8715	VBN	denotes	observed
T7522	8716-8720	IN	denotes	with
T7523	8721-8730	NN	denotes	knockdown
T7524	8731-8742	NNS	denotes	experiments
T7525	8743-8745	IN	denotes	in
T7526	8746-8750	NN	denotes	cell
T7528	8750-8751	HYPH	denotes	-
T7527	8751-8756	VBN	denotes	based
T7530	8757-8764	NN	denotes	culture
T7529	8765-8771	NNS	denotes	assays
T7531	8771-8772	.	denotes	.
T7532	8772-9024	sentence	denotes	For example, short interfering RNA-mediated knockdown of RanBP2 [9] and members of the Nup107-Nup160 complex [59–61] have shown, respectively, to cause mitotic arrest and disruption of nuclear pore assembly and deficits in mRNA export in cell culture.
T7533	8773-8776	IN	denotes	For
T7535	8777-8784	NN	denotes	example
T7536	8784-8786	,	denotes	,
T7537	8786-8791	JJ	denotes	short
T7539	8792-8803	VBG	denotes	interfering
T7540	8804-8807	NN	denotes	RNA
T7542	8807-8808	HYPH	denotes	-
T7541	8808-8816	VBN	denotes	mediated
T7538	8817-8826	NN	denotes	knockdown
T7543	8827-8829	IN	denotes	of
T7544	8830-8836	NN	denotes	RanBP2
T7545	8837-8838	-LRB-	denotes	[
T7546	8838-8839	CD	denotes	9
T7547	8839-8840	-RRB-	denotes	]
T7548	8841-8844	CC	denotes	and
T7549	8845-8852	NNS	denotes	members
T7550	8853-8855	IN	denotes	of
T7551	8856-8859	DT	denotes	the
T7553	8860-8866	NN	denotes	Nup107
T7555	8866-8867	HYPH	denotes	-
T7554	8867-8873	NN	denotes	Nup160
T7552	8874-8881	NN	denotes	complex
T7556	8882-8883	-LRB-	denotes	[
T7557	8883-8885	CD	denotes	59
T7558	8885-8886	SYM	denotes	–
T7559	8886-8888	CD	denotes	61
T7560	8888-8889	-RRB-	denotes	]
T7561	8890-8894	VBP	denotes	have
T7534	8895-8900	VBN	denotes	shown
T7562	8900-8902	,	denotes	,
T7563	8902-8914	RB	denotes	respectively
T7564	8914-8916	,	denotes	,
T7565	8916-8918	TO	denotes	to
T7566	8919-8924	VB	denotes	cause
T7567	8925-8932	JJ	denotes	mitotic
T7568	8933-8939	NN	denotes	arrest
T7569	8940-8943	CC	denotes	and
T7570	8944-8954	NN	denotes	disruption
T7571	8955-8957	IN	denotes	of
T7572	8958-8965	JJ	denotes	nuclear
T7573	8966-8970	NN	denotes	pore
T7574	8971-8979	NN	denotes	assembly
T7575	8980-8983	CC	denotes	and
T7576	8984-8992	NNS	denotes	deficits
T7577	8993-8995	IN	denotes	in
T7578	8996-9000	NN	denotes	mRNA
T7579	9001-9007	NN	denotes	export
T7580	9008-9010	IN	denotes	in
T7581	9011-9015	NN	denotes	cell
T7582	9016-9023	NN	denotes	culture
T7583	9023-9024	.	denotes	.
T7584	9024-9327	sentence	denotes	Yet, haploinsufficiency of RanBP2 (this work) and Nup96 [58] predominantly produce, instead, CNS-restricted deficits in energy metabolism and alterations in the immune system linked to the down-regulation of interferon-β-regulated proteins and increased susceptibility of viral infection, respectively.
T7585	9025-9028	RB	denotes	Yet
T7587	9028-9030	,	denotes	,
T7588	9030-9048	NN	denotes	haploinsufficiency
T7589	9049-9051	IN	denotes	of
T7590	9052-9058	NN	denotes	RanBP2
T7591	9059-9060	-LRB-	denotes	(
T7593	9060-9064	DT	denotes	this
T7592	9065-9069	NN	denotes	work
T7594	9069-9070	-RRB-	denotes	)
T7595	9071-9074	CC	denotes	and
T7596	9075-9080	NN	denotes	Nup96
T7597	9081-9082	-LRB-	denotes	[
T7598	9082-9084	CD	denotes	58
T7599	9084-9085	-RRB-	denotes	]
T7600	9086-9099	RB	denotes	predominantly
T7586	9100-9107	VBP	denotes	produce
T7601	9107-9109	,	denotes	,
T7602	9109-9116	RB	denotes	instead
T7603	9116-9118	,	denotes	,
T7604	9118-9121	NN	denotes	CNS
T7606	9121-9122	HYPH	denotes	-
T7605	9122-9132	JJ	denotes	restricted
T7607	9133-9141	NNS	denotes	deficits
T7608	9142-9144	IN	denotes	in
T7609	9145-9151	NN	denotes	energy
T7610	9152-9162	NN	denotes	metabolism
T7611	9163-9166	CC	denotes	and
T7612	9167-9178	NNS	denotes	alterations
T7613	9179-9181	IN	denotes	in
T7614	9182-9185	DT	denotes	the
T7616	9186-9192	JJ	denotes	immune
T7615	9193-9199	NN	denotes	system
T7617	9200-9206	VBN	denotes	linked
T7618	9207-9209	IN	denotes	to
T7619	9210-9213	DT	denotes	the
T7621	9214-9218	JJ	denotes	down
T7622	9218-9219	HYPH	denotes	-
T7620	9219-9229	NN	denotes	regulation
T7623	9230-9232	IN	denotes	of
T7624	9233-9243	NN	denotes	interferon
T7626	9243-9244	HYPH	denotes	-
T7625	9244-9245	NN	denotes	β
T7628	9245-9246	HYPH	denotes	-
T7627	9246-9255	VBN	denotes	regulated
T7629	9256-9264	NN	denotes	proteins
T7630	9265-9268	CC	denotes	and
T7631	9269-9278	VBN	denotes	increased
T7632	9279-9293	NN	denotes	susceptibility
T7633	9294-9296	IN	denotes	of
T7634	9297-9302	JJ	denotes	viral
T7635	9303-9312	NN	denotes	infection
T7636	9312-9314	,	denotes	,
T7637	9314-9326	RB	denotes	respectively
T7638	9326-9327	.	denotes	.
T7639	9327-9539	sentence	denotes	While these apparent outcome disparities among experimental systems remain unclear, they could potentially result from variations in redundancies and compensatory mechanisms inherent to each experimental system.
T7640	9328-9333	IN	denotes	While
T7642	9334-9339	DT	denotes	these
T7644	9340-9348	JJ	denotes	apparent
T7645	9349-9356	NN	denotes	outcome
T7643	9357-9368	NNS	denotes	disparities
T7646	9369-9374	IN	denotes	among
T7647	9375-9387	JJ	denotes	experimental
T7648	9388-9395	NNS	denotes	systems
T7641	9396-9402	VBP	denotes	remain
T7650	9403-9410	JJ	denotes	unclear
T7651	9410-9412	,	denotes	,
T7652	9412-9416	PRP	denotes	they
T7653	9417-9422	MD	denotes	could
T7654	9423-9434	RB	denotes	potentially
T7649	9435-9441	VB	denotes	result
T7655	9442-9446	IN	denotes	from
T7656	9447-9457	NNS	denotes	variations
T7657	9458-9460	IN	denotes	in
T7658	9461-9473	NNS	denotes	redundancies
T7659	9474-9477	CC	denotes	and
T7660	9478-9490	JJ	denotes	compensatory
T7661	9491-9501	NNS	denotes	mechanisms
T7662	9502-9510	JJ	denotes	inherent
T7663	9511-9513	IN	denotes	to
T7664	9514-9518	DT	denotes	each
T7666	9519-9531	JJ	denotes	experimental
T7665	9532-9538	NN	denotes	system
T7667	9538-9539	.	denotes	.
T7668	9539-9775	sentence	denotes	Regardless, these genetic and whole-animal models set the stage to probe novel molecular pathways in various physiological and genetic contexts, and provide also a link to pathophysiological processes underlying several human diseases.
T7669	9540-9550	RB	denotes	Regardless
T7671	9550-9552	,	denotes	,
T7672	9552-9557	DT	denotes	these
T7674	9558-9565	JJ	denotes	genetic
T7675	9566-9569	CC	denotes	and
T7676	9570-9575	JJ	denotes	whole
T7678	9575-9576	HYPH	denotes	-
T7677	9576-9582	NN	denotes	animal
T7673	9583-9589	NNS	denotes	models
T7670	9590-9593	VBD	denotes	set
T7679	9594-9597	DT	denotes	the
T7680	9598-9603	NN	denotes	stage
T7681	9604-9606	TO	denotes	to
T7682	9607-9612	VB	denotes	probe
T7683	9613-9618	JJ	denotes	novel
T7685	9619-9628	JJ	denotes	molecular
T7684	9629-9637	NNS	denotes	pathways
T7686	9638-9640	IN	denotes	in
T7687	9641-9648	JJ	denotes	various
T7689	9649-9662	JJ	denotes	physiological
T7690	9663-9666	CC	denotes	and
T7691	9667-9674	JJ	denotes	genetic
T7688	9675-9683	NNS	denotes	contexts
T7692	9683-9685	,	denotes	,
T7693	9685-9688	CC	denotes	and
T7694	9689-9696	VB	denotes	provide
T7695	9697-9701	RB	denotes	also
T7696	9702-9703	DT	denotes	a
T7697	9704-9708	NN	denotes	link
T7698	9709-9711	IN	denotes	to
T7699	9712-9730	JJ	denotes	pathophysiological
T7700	9731-9740	NNS	denotes	processes
T7701	9741-9751	VBG	denotes	underlying
T7702	9752-9759	JJ	denotes	several
T7704	9760-9765	JJ	denotes	human
T7703	9766-9774	NNS	denotes	diseases
T7705	9774-9775	.	denotes	.
R3551	T6106	T6107	poss	Our,findings
R3552	T6107	T6108	nsubj	findings,support
R3553	T6109	T6110	mark	that,plays
R3554	T6110	T6108	ccomp	plays,support
R3555	T6111	T6110	nsubj	RanBP2,plays
R3556	T6112	T6113	det	a,role
R3557	T6113	T6110	dobj	role,plays
R3558	T6114	T6113	amod	determinant,role
R3559	T6115	T6110	prep	in,plays
R3560	T6116	T6115	pcomp	modulating,in
R3561	T6117	T6116	dobj	glucose,modulating
R3562	T6118	T6117	cc	and,glucose
R3563	T6119	T6120	compound	energy,homeostasis
R3564	T6120	T6117	conj	homeostasis,glucose
R3565	T6121	T6108	punct	.,support
R3566	T6123	T6124	det	The,data
R3567	T6124	T6125	nsubj	data,support
R3568	T6126	T6127	mark	that,are
R3569	T6127	T6125	ccomp	are,support
R3570	T6128	T6127	nsubj	Cox1,are
R3571	T6129	T6128	cc	and,Cox1
R3572	T6130	T6128	conj	HKI,Cox1
R3573	T6131	T6132	amod	novel,partners
R3574	T6132	T6127	attr	partners,are
R3575	T6133	T6134	advmod	in,vivo
R3576	T6134	T6127	advmod	vivo,are
R3577	T6135	T6127	prep	for,are
R3578	T6136	T6137	det	the,LD
R3579	T6137	T6135	pobj	LD,for
R3580	T6138	T6137	amod	large,LD
R3581	T6139	T6137	prep	of,LD
R3582	T6140	T6139	pobj	RanBP2,of
R3583	T6141	T6142	punct	(,1
R3584	T6142	T6127	parataxis	1,are
R3585	T6143	T6142	nmod	Figures,1
R3586	T6144	T6142	cc	and,1
R3587	T6145	T6142	conj	2,1
R3588	T6146	T6142	punct	),1
R3589	T6147	T6125	punct	.,support
R3590	T6149	T6150	det	The,LD
R3591	T6150	T6151	nsubj	LD,exhibits
R3592	T6152	T6150	prep	of,LD
R3593	T6153	T6152	pobj	RanBP2,of
R3594	T6154	T6155	compound	chaperone,activity
R3595	T6155	T6151	dobj	activity,exhibits
R3596	T6156	T6155	prep	toward,activity
R3597	T6157	T6158	compound	folding,intermediates
R3598	T6158	T6156	pobj	intermediates,toward
R3599	T6159	T6158	prep	of,intermediates
R3600	T6160	T6159	pobj	Cox11,of
R3601	T6161	T6158	punct	", ",intermediates
R3602	T6162	T6158	cc	and,intermediates
R3603	T6163	T6164	advmod	possibly,HKI
R3604	T6164	T6158	conj	HKI,intermediates
R3605	T6165	T6164	punct	", ",HKI
R3606	T6166	T6164	det	the,HKI
R3607	T6167	T6164	amod	mature,HKI
R3608	T6168	T6169	punct	(,Figure
R3609	T6169	T6151	parataxis	Figure,exhibits
R3610	T6170	T6169	nummod	1,Figure
R3611	T6171	T6169	punct	),Figure
R3612	T6172	T6151	punct	.,exhibits
R3613	T6174	T6175	nsubj	Cox11,inhibits
R3614	T6176	T6175	advmod	noncompetitively,inhibits
R3615	T6177	T6178	det	the,activity
R3616	T6178	T6175	dobj	activity,inhibits
R3617	T6179	T6178	prep	of,activity
R3618	T6180	T6179	pobj	HKI,of
R3619	T6181	T6182	mark	with,required
R3620	T6182	T6175	advcl	required,inhibits
R3621	T6183	T6184	punct	~,3
R3622	T6184	T6187	nummod	3,molecules
R3623	T6185	T6184	quantmod	2,3
R3624	T6186	T6184	punct	–,3
R3625	T6187	T6182	nsubj	molecules,required
R3626	T6188	T6187	prep	of,molecules
R3627	T6189	T6188	pobj	Cox11,of
R3628	T6190	T6191	punct	(,assuming
R3629	T6191	T6187	parataxis	assuming,molecules
R3630	T6192	T6191	dobj	formation,assuming
R3631	T6193	T6192	prep	of,formation
R3632	T6194	T6195	compound	Cox11,dimer
R3633	T6195	T6193	pobj	dimer,of
R3634	T6196	T6191	punct	),assuming
R3635	T6197	T6198	aux	to,inhibit
R3636	T6198	T6182	advcl	inhibit,required
R3637	T6199	T6198	advmod	completely,inhibit
R3638	T6200	T6201	det	the,activity
R3639	T6201	T6198	dobj	activity,inhibit
R3640	T6202	T6201	prep	of,activity
R3641	T6203	T6204	det	a,molecule
R3642	T6204	T6202	pobj	molecule,of
R3643	T6205	T6204	prep	of,molecule
R3644	T6206	T6205	pobj	HKI,of
R3645	T6207	T6208	punct	(,2A
R3646	T6208	T6175	parataxis	2A,inhibits
R3647	T6209	T6208	compound	Figure,2A
R3648	T6210	T6208	cc	and,2A
R3649	T6211	T6208	conj	2B,2A
R3650	T6212	T6208	punct	),2A
R3651	T6213	T6175	punct	.,inhibits
R3652	T6215	T6216	nsubj	Cox11,sequesters
R3653	T6217	T6216	dobj	HKI,sequesters
R3654	T6218	T6216	prep	by,sequesters
R3655	T6219	T6218	pcomp	binding,by
R3656	T6220	T6219	prep	to,binding
R3657	T6221	T6220	pobj	HKI,to
R3658	T6222	T6219	prep	at,binding
R3659	T6223	T6224	det	a,site
R3660	T6224	T6222	pobj	site,at
R3661	T6225	T6226	dep	that,is
R3662	T6226	T6224	relcl	is,site
R3663	T6227	T6226	acomp	distinct,is
R3664	T6228	T6227	prep	from,distinct
R3665	T6229	T6230	det	the,site
R3666	T6230	T6228	pobj	site,from
R3667	T6231	T6230	amod	active,site
R3668	T6232	T6226	cc	and,is
R3669	T6233	T6234	advmod	effectively,reduces
R3670	T6234	T6226	conj	reduces,is
R3671	T6235	T6236	det	the,availability
R3672	T6236	T6234	dobj	availability,reduces
R3673	T6237	T6236	prep	of,availability
R3674	T6238	T6239	punct	[,tot
R3675	T6239	T6237	pobj	tot,of
R3676	T6240	T6239	nmod	HKI,tot
R3677	T6241	T6239	punct	],tot
R3678	T6242	T6236	prep	for,availability
R3679	T6243	T6242	pobj	catalysis,for
R3680	T6244	T6216	punct	.,sequesters
R3681	T6246	T6247	nsubjpass	This,reflected
R3682	T6248	T6247	auxpass	is,reflected
R3683	T6249	T6247	agent	by,reflected
R3684	T6250	T6251	det	a,reduction
R3685	T6251	T6249	pobj	reduction,by
R3686	T6252	T6251	prep	of,reduction
R3687	T6253	T6254	det	the,V max
R3688	T6254	T6252	pobj	V max,of
R3689	T6255	T6254	prep	of,V max
R3690	T6256	T6255	pobj	HKI,of
R3691	T6257	T6251	prep	without,reduction
R3692	T6258	T6259	advmod	significantly,affecting
R3693	T6259	T6257	pcomp	affecting,without
R3694	T6260	T6261	det	the,K m
R3695	T6261	T6259	dobj	K m,affecting
R3696	T6262	T6261	prep	of,K m
R3697	T6263	T6264	det	the,site
R3698	T6264	T6262	pobj	site,of
R3699	T6265	T6264	amod	active,site
R3700	T6266	T6264	prep	of,site
R3701	T6267	T6266	pobj	HKI,of
R3702	T6268	T6261	prep	toward,K m
R3703	T6269	T6268	pobj	glucose,toward
R3704	T6270	T6271	punct	(,2A
R3705	T6271	T6247	parataxis	2A,reflected
R3706	T6272	T6271	compound	Figure,2A
R3707	T6273	T6271	cc	and,2A
R3708	T6274	T6271	conj	2B,2A
R3709	T6275	T6271	punct	),2A
R3710	T6276	T6247	punct	.,reflected
R3711	T6278	T6279	det	The,property
R3712	T6279	T6281	nsubjpass	property,suppressed
R3713	T6280	T6279	amod	inhibitory,property
R3714	T6282	T6279	prep	of,property
R3715	T6283	T6282	pobj	Cox11,of
R3716	T6284	T6279	prep	over,property
R3717	T6285	T6284	pobj	HKI,over
R3718	T6286	T6281	auxpass	is,suppressed
R3719	T6287	T6281	agent	by,suppressed
R3720	T6288	T6287	pobj	RanBP2,by
R3721	T6289	T6290	punct	(,2C
R3722	T6290	T6288	parataxis	2C,RanBP2
R3723	T6291	T6290	compound	Figure,2C
R3724	T6292	T6290	punct	),2C
R3725	T6293	T6288	punct	", ",RanBP2
R3726	T6294	T6295	dep	which,has
R3727	T6295	T6288	relcl	has,RanBP2
R3728	T6296	T6295	prep	by,has
R3729	T6297	T6296	pobj	itself,by
R3730	T6298	T6299	det	a,activity
R3731	T6299	T6295	dobj	activity,has
R3732	T6300	T6299	amod	weak,activity
R3733	T6301	T6300	cc	but,weak
R3734	T6302	T6300	conj	significant,weak
R3735	T6303	T6299	amod	inhibitory,activity
R3736	T6304	T6299	prep	over,activity
R3737	T6305	T6304	pobj	HKI,over
R3738	T6306	T6307	punct	(,2D
R3739	T6307	T6295	parataxis	2D,has
R3740	T6308	T6307	compound	Figure,2D
R3741	T6309	T6307	punct	),2D
R3742	T6310	T6281	punct	.,suppressed
R3743	T6312	T6313	det	The,effect
R3744	T6313	T6315	nsubj	effect,supports
R3745	T6314	T6313	amod	sub-stochiometry,effect
R3746	T6316	T6313	prep	of,effect
R3747	T6317	T6318	det	the,LD
R3748	T6318	T6316	pobj	LD,of
R3749	T6319	T6318	prep	of,LD
R3750	T6320	T6319	pobj	RanBP2,of
R3751	T6321	T6313	prep	over,effect
R3752	T6322	T6323	det	the,inhibition
R3753	T6323	T6321	pobj	inhibition,over
R3754	T6324	T6323	prep	of,inhibition
R3755	T6325	T6324	pobj	HKI,of
R3756	T6326	T6323	prep	by,inhibition
R3757	T6327	T6326	pobj	Cox11,by
R3758	T6328	T6329	mark	that,underlies
R3759	T6329	T6315	advcl	underlies,supports
R3760	T6330	T6331	det	a,mechanism
R3761	T6331	T6329	nsubj	mechanism,underlies
R3762	T6332	T6333	npadvmod	LD,dependent
R3763	T6333	T6331	amod	dependent,mechanism
R3764	T6334	T6333	punct	-,dependent
R3765	T6335	T6336	npadvmod	chaperonin,like
R3766	T6336	T6331	amod	like,mechanism
R3767	T6337	T6336	punct	-,like
R3768	T6338	T6339	det	the,suppression
R3769	T6339	T6329	dobj	suppression,underlies
R3770	T6340	T6339	prep	of,suppression
R3771	T6341	T6342	amod	Cox11,dependent
R3772	T6342	T6344	amod	dependent,inhibition
R3773	T6343	T6342	punct	-,dependent
R3774	T6344	T6340	pobj	inhibition,of
R3775	T6345	T6344	prep	of,inhibition
R3776	T6346	T6345	pobj	HKI,of
R3777	T6347	T6344	prep	by,inhibition
R3778	T6348	T6347	pobj	RanBP2,by
R3779	T6349	T6329	punct	", ",underlies
R3780	T6350	T6329	cc	and,underlies
R3781	T6351	T6352	mark	that,acts
R3782	T6352	T6329	conj	acts,underlies
R3783	T6353	T6352	nsubj	RanBP2,acts
R3784	T6354	T6352	prep	as,acts
R3785	T6355	T6356	det	a,buffer
R3786	T6356	T6354	pobj	buffer,as
R3787	T6357	T6356	amod	molecular,buffer
R3788	T6358	T6356	punct	“,buffer
R3789	T6359	T6356	punct	”,buffer
R3790	T6360	T6356	prep	over,buffer
R3791	T6361	T6362	nmod	HK1,activities
R3792	T6362	T6360	pobj	activities,over
R3793	T6363	T6361	cc	and,HK1
R3794	T6364	T6361	conj	Cox11,HK1
R3795	T6365	T6315	punct	.,supports
R3796	T6367	T6368	det	The,loss
R3797	T6368	T6370	nsubj	loss,leads
R3798	T6369	T6368	amod	partial,loss
R3799	T6371	T6368	prep	of,loss
R3800	T6372	T6373	det	the,activity
R3801	T6373	T6371	pobj	activity,of
R3802	T6374	T6373	compound	RanBP2,activity
R3803	T6375	T6373	compound	chaperone,activity
R3804	T6376	T6368	prep	in,loss
R3805	T6377	T6378	nmod	RanBP2,mice
R3806	T6378	T6376	pobj	mice,in
R3807	T6379	T6377	punct	+,RanBP2
R3808	T6380	T6377	punct	/,RanBP2
R3809	T6381	T6377	punct	−,RanBP2
R3810	T6382	T6370	advmod	also,leads
R3811	T6383	T6370	prep	to,leads
R3812	T6384	T6383	pobj	deficits,to
R3813	T6385	T6384	prep	in,deficits
R3814	T6386	T6387	det	the,sequestration
R3815	T6387	T6385	pobj	sequestration,in
R3816	T6388	T6387	prep	of,sequestration
R3817	T6389	T6388	pobj	HKI,of
R3818	T6390	T6384	prep	in,deficits
R3819	T6391	T6392	det	the,compartment
R3820	T6392	T6390	pobj	compartment,in
R3821	T6393	T6392	amod	ellipsoid,compartment
R3822	T6394	T6392	prep	of,compartment
R3823	T6395	T6396	amod	photosensory,neurons
R3824	T6396	T6394	pobj	neurons,of
R3825	T6397	T6370	punct	.,leads
R3826	T6399	T6400	nsubj	This,underlies
R3827	T6401	T6400	advmod	possibly,underlies
R3828	T6402	T6403	det	the,mistargeting
R3829	T6403	T6400	dobj	mistargeting,underlies
R3830	T6404	T6403	prep	of,mistargeting
R3831	T6405	T6404	pobj	HKI,of
R3832	T6406	T6403	prep	to,mistargeting
R3833	T6407	T6408	det	the,compartment
R3834	T6408	T6406	pobj	compartment,to
R3835	T6409	T6408	amod	myoid,compartment
R3836	T6410	T6408	prep	of,compartment
R3837	T6411	T6412	det	these,neurons
R3838	T6412	T6410	pobj	neurons,of
R3839	T6413	T6414	punct	(,S2
R3840	T6414	T6400	parataxis	S2,underlies
R3841	T6415	T6414	compound	Figure,S2
R3842	T6416	T6414	punct	),S2
R3843	T6417	T6400	punct	.,underlies
R3844	T6419	T6420	det	The,data
R3845	T6420	T6421	nsubj	data,support
R3846	T6422	T6423	mark	that,is
R3847	T6423	T6421	ccomp	is,support
R3848	T6424	T6425	det	the,outcome
R3849	T6425	T6423	nsubj	outcome,is
R3850	T6426	T6425	amod	ultimate,outcome
R3851	T6427	T6425	amod	pathophysiological,outcome
R3852	T6428	T6425	prep	in,outcome
R3853	T6429	T6428	pobj	HKI,in
R3854	T6430	T6425	punct	", ",outcome
R3855	T6431	T6425	acl	caused,outcome
R3856	T6432	T6431	agent	by,caused
R3857	T6433	T6434	det	a,reduction
R3858	T6434	T6432	pobj	reduction,by
R3859	T6435	T6434	prep	in,reduction
R3860	T6436	T6437	compound	RanBP2,levels
R3861	T6437	T6435	pobj	levels,in
R3862	T6438	T6437	cc	and,levels
R3863	T6439	T6440	poss	its,activity
R3864	T6440	T6437	conj	activity,levels
R3865	T6441	T6440	compound	chaperone,activity
R3866	T6442	T6423	punct	", ",is
R3867	T6443	T6444	det	the,degradation
R3868	T6444	T6423	attr	degradation,is
R3869	T6445	T6444	amod	selective,degradation
R3870	T6446	T6444	prep	of,degradation
R3871	T6447	T6446	pobj	HKI,of
R3872	T6448	T6449	mark	as,reflected
R3873	T6449	T6423	advcl	reflected,is
R3874	T6450	T6449	agent	by,reflected
R3875	T6451	T6452	det	the,levels
R3876	T6452	T6450	pobj	levels,by
R3877	T6453	T6452	amod	reduced,levels
R3878	T6454	T6452	prep	of,levels
R3879	T6455	T6454	pobj	HKI,of
R3880	T6456	T6455	punct	(,HKI
R3881	T6457	T6455	cc	and,HKI
R3882	T6458	T6455	conj	ATP,HKI
R3883	T6459	T6454	punct	),of
R3884	T6460	T6454	cc	but,of
R3885	T6461	T6460	neg	not,but
R3886	T6462	T6454	conj	of,of
R3887	T6463	T6464	amod	other,components
R3888	T6464	T6462	pobj	components,of
R3889	T6465	T6464	amod	mitochondrial,components
R3890	T6466	T6465	cc	and,mitochondrial
R3891	T6467	T6465	conj	NPC,mitochondrial
R3892	T6468	T6469	punct	(,Figure
R3893	T6469	T6423	parataxis	Figure,is
R3894	T6470	T6469	nummod	5,Figure
R3895	T6471	T6469	punct	),Figure
R3896	T6472	T6421	punct	.,support
R3897	T6474	T6475	prep	Through,is
R3898	T6476	T6477	det	this,process
R3899	T6477	T6474	pobj	process,Through
R3900	T6478	T6475	punct	", ",is
R3901	T6479	T6475	nsubj	it,is
R3902	T6480	T6475	advmod	also,is
R3903	T6481	T6475	acomp	possible,is
R3904	T6482	T6483	mark	that,cause
R3905	T6483	T6475	ccomp	cause,is
R3906	T6484	T6483	nsubj	deficits,cause
R3907	T6485	T6484	prep	in,deficits
R3908	T6486	T6485	pobj	RanBP2,in
R3909	T6487	T6488	det	a,disturbance
R3910	T6488	T6483	dobj	disturbance,cause
R3911	T6489	T6488	prep	in,disturbance
R3912	T6490	T6491	det	the,equilibrium
R3913	T6491	T6489	pobj	equilibrium,in
R3914	T6492	T6491	prep	between,equilibrium
R3915	T6493	T6492	pobj	Cox11,between
R3916	T6494	T6493	punct	", ",Cox11
R3917	T6495	T6493	conj	HK1,Cox11
R3918	T6496	T6495	punct	", ",HK1
R3919	T6497	T6495	cc	and,HK1
R3920	T6498	T6495	conj	RanBP2,HK1
R3921	T6499	T6483	prep	by,cause
R3922	T6500	T6499	pcomp	leading,by
R3923	T6501	T6500	prep	to,leading
R3924	T6502	T6503	det	an,increase
R3925	T6503	T6501	pobj	increase,to
R3926	T6504	T6503	prep	of,increase
R3927	T6505	T6506	det	the,activity
R3928	T6506	T6504	pobj	activity,of
R3929	T6507	T6506	amod	inhibitory,activity
R3930	T6508	T6506	prep	of,activity
R3931	T6509	T6508	pobj	Cox11,of
R3932	T6510	T6506	prep	over,activity
R3933	T6511	T6510	pobj	HKI,over
R3934	T6512	T6513	dep	that,promotes
R3935	T6513	T6506	relcl	promotes,activity
R3936	T6514	T6515	det	the,uncoupling
R3937	T6515	T6513	dobj	uncoupling,promotes
R3938	T6516	T6515	prep	of,uncoupling
R3939	T6517	T6518	det	the,interaction
R3940	T6518	T6516	pobj	interaction,of
R3941	T6519	T6518	prep	of,interaction
R3942	T6520	T6519	pobj	HKI,of
R3943	T6521	T6515	prep	from,uncoupling
R3944	T6522	T6521	pobj	RanBP2,from
R3945	T6523	T6513	punct	", ",promotes
R3946	T6524	T6525	advmod	ultimately,causing
R3947	T6525	T6513	advcl	causing,promotes
R3948	T6526	T6527	compound	HKI,degradation
R3949	T6527	T6525	dobj	degradation,causing
R3950	T6528	T6475	punct	.,is
R3951	T6530	T6531	advmod	Regardless,contribute
R3952	T6532	T6531	punct	", ",contribute
R3953	T6533	T6534	amod	lower,levels
R3954	T6534	T6531	nsubj	levels,contribute
R3955	T6535	T6534	prep	of,levels
R3956	T6536	T6535	pobj	HKI,of
R3957	T6537	T6531	advmod	likely,contribute
R3958	T6538	T6531	prep	to,contribute
R3959	T6539	T6540	det	the,levels
R3960	T6540	T6538	pobj	levels,to
R3961	T6541	T6540	amod	decreased,levels
R3962	T6542	T6540	prep	in,levels
R3963	T6543	T6542	pobj	ATP,in
R3964	T6544	T6540	punct	", ",levels
R3965	T6545	T6546	amod	slower,rates
R3966	T6546	T6540	conj	rates,levels
R3967	T6547	T6546	compound	growth,rates
R3968	T6548	T6546	punct	", ",rates
R3969	T6549	T6546	cc	and,rates
R3970	T6550	T6551	amod	diminished,ability
R3971	T6551	T6546	conj	ability,rates
R3972	T6552	T6553	aux	to,metabolize
R3973	T6553	T6551	acl	metabolize,ability
R3974	T6554	T6553	dobj	glucose,metabolize
R3975	T6555	T6554	prep	of,glucose
R3976	T6556	T6557	nmod	RanBP2,mice
R3977	T6557	T6555	pobj	mice,of
R3978	T6558	T6556	punct	+,RanBP2
R3979	T6559	T6556	punct	/,RanBP2
R3980	T6560	T6556	punct	−,RanBP2
R3981	T6561	T6562	punct	(,Figures
R3982	T6562	T6531	parataxis	Figures,contribute
R3983	T6563	T6562	nummod	5,Figures
R3984	T6564	T6565	punct	–,7
R3985	T6565	T6562	prep	7,Figures
R3986	T6566	T6562	punct	),Figures
R3987	T6567	T6531	punct	.,contribute
R3988	T6569	T6570	mark	As,discussed
R3989	T6570	T6571	advcl	discussed,account
R3990	T6572	T6570	advmod	subsequently,discussed
R3991	T6573	T6571	punct	", ",account
R3992	T6574	T6575	det	the,deficits
R3993	T6575	T6571	nsubj	deficits,account
R3994	T6576	T6575	compound	ATP,deficits
R3995	T6577	T6575	prep	in,deficits
R3996	T6578	T6579	det	the,retina
R3997	T6579	T6577	pobj	retina,in
R3998	T6580	T6571	advmod	likely,account
R3999	T6581	T6571	prep	for,account
R4000	T6582	T6583	det	the,responses
R4001	T6583	T6581	pobj	responses,for
R4002	T6584	T6583	amod	reduced,responses
R4003	T6585	T6583	amod	electrophysiological,responses
R4004	T6586	T6583	prep	of,responses
R4005	T6587	T6588	amod	retinal,neurons
R4006	T6588	T6586	pobj	neurons,of
R4007	T6589	T6590	punct	(,Figure
R4008	T6590	T6571	parataxis	Figure,account
R4009	T6591	T6590	nummod	8,Figure
R4010	T6592	T6590	punct	),Figure
R4011	T6593	T6571	punct	.,account
R4012	T6595	T6596	amod	Various,domains
R4013	T6596	T6597	nsubjpass	domains,implicated
R4014	T6598	T6596	prep	of,domains
R4015	T6599	T6598	pobj	RanBP2,of
R4016	T6600	T6597	aux	have,implicated
R4017	T6601	T6597	auxpass	been,implicated
R4018	T6602	T6597	advmod	previously,implicated
R4019	T6603	T6597	prep	with,implicated
R4020	T6604	T6605	det	a,role
R4021	T6605	T6603	pobj	role,with
R4022	T6606	T6605	compound	chaperone,role
R4023	T6607	T6605	prep	in,role
R4024	T6608	T6609	det	the,cell
R4025	T6609	T6607	pobj	cell,in
R4026	T6610	T6597	punct	.,implicated
R4027	T6612	T6613	nsubj	These,include
R4028	T6614	T6615	det	the,enhancement
R4029	T6615	T6613	dobj	enhancement,include
R4030	T6616	T6615	prep	of,enhancement
R4031	T6617	T6618	det	the,biogenesis
R4032	T6618	T6616	pobj	biogenesis,of
R4033	T6619	T6618	prep	of,biogenesis
R4034	T6620	T6621	amod	red,green
R4035	T6621	T6623	amod	green,opsin
R4036	T6622	T6621	punct	/,green
R4037	T6623	T6619	pobj	opsin,of
R4038	T6624	T6615	prep	by,enhancement
R4039	T6625	T6626	det	the,combination
R4040	T6626	T6624	pobj	combination,by
R4041	T6627	T6626	prep	of,combination
R4042	T6628	T6629	det	the,domains
R4043	T6629	T6627	pobj	domains,of
R4044	T6630	T6631	compound	RBD4,CY
R4045	T6631	T6629	compound	CY,domains
R4046	T6632	T6631	punct	-,CY
R4047	T6633	T6634	punct	[,7
R4048	T6634	T6615	parataxis	7,enhancement
R4049	T6635	T6634	nummod	6,7
R4050	T6636	T6634	punct	",",7
R4051	T6637	T6634	punct	],7
R4052	T6638	T6615	cc	and,enhancement
R4053	T6639	T6640	det	the,stabilization
R4054	T6640	T6615	conj	stabilization,enhancement
R4055	T6641	T6640	prep	by,stabilization
R4056	T6642	T6643	det	the,domains
R4057	T6643	T6641	pobj	domains,by
R4058	T6644	T6645	npadvmod	Ran,binding
R4059	T6645	T6643	amod	binding,domains
R4060	T6646	T6645	punct	-,binding
R4061	T6647	T6643	prep	of,domains
R4062	T6648	T6647	pobj	RanBP2,of
R4063	T6649	T6640	prep	of,stabilization
R4064	T6650	T6651	det	the,state
R4065	T6651	T6649	pobj	state,of
R4066	T6652	T6653	compound	guanosine,triphosphate
R4067	T6653	T6654	npadvmod	triphosphate,bound
R4068	T6654	T6651	amod	bound,state
R4069	T6655	T6654	punct	-,bound
R4070	T6656	T6651	amod	conformational,state
R4071	T6657	T6651	prep	of,state
R4072	T6658	T6657	pobj	RanGTPase,of
R4073	T6659	T6640	cc	and,stabilization
R4074	T6660	T6640	conj	interaction,stabilization
R4075	T6661	T6660	prep	of,interaction
R4076	T6662	T6661	pobj	Ran,of
R4077	T6663	T6660	prep	with,interaction
R4078	T6664	T6665	compound	importin,β
R4079	T6665	T6663	pobj	β,with
R4080	T6666	T6665	punct	-,β
R4081	T6667	T6668	punct	[,41
R4082	T6668	T6613	parataxis	41,include
R4083	T6669	T6668	nummod	11,41
R4084	T6670	T6668	punct	",",41
R4085	T6671	T6668	nummod	40,41
R4086	T6672	T6668	punct	",",41
R4087	T6673	T6668	punct	],41
R4088	T6674	T6613	punct	.,include
R4089	T6676	T6677	det	The,data
R4090	T6677	T6678	nsubj	data,show
R4091	T6679	T6677	advmod	herein,data
R4092	T6680	T6681	mark	that,extends
R4093	T6681	T6678	ccomp	extends,show
R4094	T6682	T6683	det	the,role
R4095	T6683	T6681	nsubj	role,extends
R4096	T6684	T6683	amod	multi-chaperone,role
R4097	T6685	T6683	prep	of,role
R4098	T6686	T6685	pobj	RanBP2,of
R4099	T6687	T6681	advmod	also,extends
R4100	T6688	T6681	prep	to,extends
R4101	T6689	T6690	poss	its,LD
R4102	T6690	T6688	pobj	LD,to
R4103	T6691	T6681	prep	in,extends
R4104	T6692	T6691	pobj	light,in
R4105	T6693	T6692	prep	of,light
R4106	T6694	T6695	poss	its,ability
R4107	T6695	T6693	pobj	ability,of
R4108	T6696	T6697	aux	to,associate
R4109	T6697	T6695	acl	associate,ability
R4110	T6698	T6697	prep	to,associate
R4111	T6699	T6700	amod	distinct,species
R4112	T6700	T6698	pobj	species,to
R4113	T6701	T6700	compound	folding,species
R4114	T6702	T6700	prep	of,species
R4115	T6703	T6702	pobj	Cox11,of
R4116	T6704	T6697	cc	and,associate
R4117	T6705	T6706	aux	to,prevent
R4118	T6706	T6697	conj	prevent,associate
R4119	T6707	T6706	dobj	HKI,prevent
R4120	T6708	T6706	prep	from,prevent
R4121	T6709	T6710	auxpass	being,degraded
R4122	T6710	T6708	pcomp	degraded,from
R4123	T6711	T6678	punct	.,show
R4124	T6713	T6714	det	This,function
R4125	T6714	T6716	nsubj	function,is
R4126	T6715	T6714	compound	chaperone,function
R4127	T6717	T6716	acomp	likely,is
R4128	T6718	T6719	aux	to,complemented
R4129	T6719	T6717	xcomp	complemented,likely
R4130	T6720	T6719	auxpass	be,complemented
R4131	T6721	T6719	agent	by,complemented
R4132	T6722	T6723	amod	other,partners
R4133	T6723	T6721	pobj	partners,by
R4134	T6724	T6723	prep	of,partners
R4135	T6725	T6724	pobj	RanBP2,of
R4136	T6726	T6723	prep	with,partners
R4137	T6727	T6728	amod	similar,functions
R4138	T6728	T6726	pobj	functions,with
R4139	T6729	T6727	cc	and,similar
R4140	T6730	T6727	conj	pleiotropic,similar
R4141	T6731	T6716	punct	.,is
R4142	T6733	T6734	prep	For,contribute
R4143	T6735	T6733	pobj	example,For
R4144	T6736	T6734	punct	", ",contribute
R4145	T6737	T6738	det	the,combination
R4146	T6738	T6734	nsubj	combination,contribute
R4147	T6739	T6738	prep	of,combination
R4148	T6740	T6741	det	the,CLD
R4149	T6741	T6739	pobj	CLD,of
R4150	T6742	T6741	prep	of,CLD
R4151	T6743	T6742	pobj	RanBP2,of
R4152	T6744	T6738	prep	with,combination
R4153	T6745	T6746	amod	several,subunits
R4154	T6746	T6744	pobj	subunits,with
R4155	T6747	T6746	prep	of,subunits
R4156	T6748	T6749	det	the,cap
R4157	T6749	T6747	pobj	cap,of
R4158	T6750	T6749	compound	19S,cap
R4159	T6751	T6749	prep	of,cap
R4160	T6752	T6753	det	the,proteasome
R4161	T6753	T6751	pobj	proteasome,of
R4162	T6754	T6755	punct	[,14
R4163	T6755	T6746	parataxis	14,subunits
R4164	T6756	T6755	punct	],14
R4165	T6757	T6738	punct	", ",combination
R4166	T6758	T6738	cc	and,combination
R4167	T6759	T6760	prep	of,with
R4168	T6760	T6738	conj	with,combination
R4169	T6761	T6762	poss	its,repeat
R4170	T6762	T6759	pobj	repeat,of
R4171	T6763	T6762	amod	neighboring,repeat
R4172	T6764	T6762	amod	internal,repeat
R4173	T6765	T6762	punct	", ",repeat
R4174	T6766	T6767	compound	W1W2,IR
R4175	T6767	T6762	appos	IR,repeat
R4176	T6768	T6767	punct	/,IR
R4177	T6769	T6770	det	the,ligase
R4178	T6770	T6760	pobj	ligase,with
R4179	T6771	T6772	compound	E3,ubiquitin
R4180	T6772	T6770	compound	ubiquitin,ligase
R4181	T6773	T6772	punct	-,ubiquitin
R4182	T6774	T6770	punct	", ",ligase
R4183	T6775	T6770	appos	parkin,ligase
R4184	T6776	T6777	punct	[,20
R4185	T6777	T6775	parataxis	20,parkin
R4186	T6778	T6777	punct	],20
R4187	T6779	T6770	punct	", ",ligase
R4188	T6780	T6770	cc	and,ligase
R4189	T6781	T6782	det	the,protein
R4190	T6782	T6770	conj	protein,ligase
R4191	T6783	T6782	nmod	E2,protein
R4192	T6784	T6785	npadvmod	SUMO,conjugating
R4193	T6785	T6782	amod	conjugating,protein
R4194	T6786	T6784	punct	-,SUMO
R4195	T6787	T6784	nummod	1,SUMO
R4196	T6788	T6785	punct	-,conjugating
R4197	T6789	T6782	punct	", ",protein
R4198	T6790	T6782	appos	Ubc9,protein
R4199	T6791	T6792	punct	[,15
R4200	T6792	T6790	parataxis	15,Ubc9
R4201	T6793	T6792	punct	],15
R4202	T6794	T6734	aux	may,contribute
R4203	T6795	T6734	prep	to,contribute
R4204	T6796	T6797	det	the,regulation
R4205	T6797	T6795	pobj	regulation,to
R4206	T6798	T6797	amod	down,regulation
R4207	T6799	T6797	punct	-,regulation
R4208	T6800	T6797	prep	of,regulation
R4209	T6801	T6800	pobj	HKI,of
R4210	T6802	T6797	prep	by,regulation
R4211	T6803	T6804	compound	26S,proteasome
R4212	T6804	T6805	npadvmod	proteasome,mediated
R4213	T6805	T6807	amod	mediated,proteolysis
R4214	T6806	T6805	punct	-,mediated
R4215	T6807	T6802	pobj	proteolysis,by
R4216	T6808	T6807	cc	and,proteolysis
R4217	T6809	T6807	conj	modulation,proteolysis
R4218	T6810	T6807	prep	of,proteolysis
R4219	T6811	T6812	det	the,partitioning
R4220	T6812	T6810	pobj	partitioning,of
R4221	T6813	T6812	amod	molecular,partitioning
R4222	T6814	T6813	cc	and,molecular
R4223	T6815	T6813	conj	subcellular,molecular
R4224	T6816	T6812	prep	of,partitioning
R4225	T6817	T6818	det	these,partners
R4226	T6818	T6816	pobj	partners,of
R4227	T6819	T6734	punct	.,contribute
R4228	T6821	T6822	prep	In,be
R4229	T6823	T6824	det	this,regard
R4230	T6824	T6821	pobj	regard,In
R4231	T6825	T6822	punct	", ",be
R4232	T6826	T6822	nsubj	it,be
R4233	T6827	T6822	aux	will,be
R4234	T6828	T6822	acomp	interesting,be
R4235	T6829	T6830	aux	to,probe
R4236	T6830	T6822	xcomp	probe,be
R4237	T6831	T6832	mark	whether,causes
R4238	T6832	T6830	ccomp	causes,probe
R4239	T6833	T6832	nsubj	parkin,causes
R4240	T6834	T6832	advmod	also,causes
R4241	T6835	T6832	dobj	deficits,causes
R4242	T6836	T6835	prep	in,deficits
R4243	T6837	T6836	pobj	HKI,in
R4244	T6838	T6832	prep	in,causes
R4245	T6839	T6840	amod	dopaminergic,neurons
R4246	T6840	T6838	pobj	neurons,in
R4247	T6841	T6822	punct	", ",be
R4248	T6842	T6843	mark	since,reported
R4249	T6843	T6822	advcl	reported,be
R4250	T6844	T6843	nsubjpass	parkin,reported
R4251	T6845	T6843	auxpass	was,reported
R4252	T6846	T6847	aux	to,modulate
R4253	T6847	T6843	xcomp	modulate,reported
R4254	T6848	T6849	compound	RanBP2,turnover
R4255	T6849	T6847	dobj	turnover,modulate
R4256	T6850	T6851	punct	[,20
R4257	T6851	T6843	parataxis	20,reported
R4258	T6852	T6851	punct	],20
R4259	T6853	T6843	punct	", ",reported
R4260	T6854	T6843	cc	and,reported
R4261	T6855	T6856	compound	parkin,loss
R4262	T6856	T6857	nsubj	loss,causes
R4263	T6857	T6843	conj	causes,reported
R4264	T6858	T6856	punct	-,loss
R4265	T6859	T6856	prep	of,loss
R4266	T6860	T6859	punct	-,of
R4267	T6861	T6859	pobj	function,of
R4268	T6862	T6857	advmod	also,causes
R4269	T6863	T6864	nmod	energy,deficits
R4270	T6864	T6857	dobj	deficits,causes
R4271	T6865	T6863	cc	and,energy
R4272	T6866	T6863	conj	growth,energy
R4273	T6867	T6868	punct	[,42
R4274	T6868	T6857	parataxis	42,causes
R4275	T6869	T6868	dep	26,42
R4276	T6870	T6871	punct	–,29
R4277	T6871	T6869	prep	29,26
R4278	T6872	T6868	punct	",",42
R4279	T6873	T6868	punct	],42
R4280	T6874	T6822	punct	.,be
R4281	T6876	T6877	det	These,data
R4282	T6877	T6878	nsubj	data,add
R4283	T6879	T6880	det	a,dimension
R4284	T6880	T6878	dobj	dimension,add
R4285	T6881	T6880	amod	new,dimension
R4286	T6882	T6878	prep	to,add
R4287	T6883	T6884	det	the,complexity
R4288	T6884	T6882	pobj	complexity,to
R4289	T6885	T6884	prep	of,complexity
R4290	T6886	T6887	det	the,regulation
R4291	T6887	T6885	pobj	regulation,of
R4292	T6888	T6887	prep	of,regulation
R4293	T6889	T6890	det	the,pathway
R4294	T6890	T6888	pobj	pathway,of
R4295	T6891	T6890	amod	glycolytic,pathway
R4296	T6892	T6887	punct	", ",regulation
R4297	T6893	T6894	prep	in,in
R4298	T6894	T6887	prep	in,regulation
R4299	T6895	T6893	amod	particular,in
R4300	T6896	T6897	det	the,CNS
R4301	T6897	T6894	pobj	CNS,in
R4302	T6898	T6897	punct	", ",CNS
R4303	T6899	T6900	advmod	where,plays
R4304	T6900	T6897	advcl	plays,CNS
R4305	T6901	T6900	nsubj	glycolysis,plays
R4306	T6902	T6903	det	a,role
R4307	T6903	T6900	dobj	role,plays
R4308	T6904	T6903	amod	major,role
R4309	T6905	T6900	prep	in,plays
R4310	T6906	T6905	pcomp	supplying,in
R4311	T6907	T6906	dobj	energy,supplying
R4312	T6908	T6900	cc	and,plays
R4313	T6909	T6910	advmod	where,play
R4314	T6910	T6900	conj	play,plays
R4315	T6911	T6912	det	the,machinery
R4316	T6912	T6910	nsubj	machinery,play
R4317	T6913	T6912	compound	proteasome,machinery
R4318	T6914	T6910	aux	may,play
R4319	T6915	T6916	det	a,role
R4320	T6916	T6910	dobj	role,play
R4321	T6917	T6916	amod	critical,role
R4322	T6918	T6910	prep	in,play
R4323	T6919	T6918	pcomp	modulating,in
R4324	T6920	T6919	dobj	components,modulating
R4325	T6921	T6920	prep	of,components
R4326	T6922	T6923	det	the,machinery
R4327	T6923	T6921	pobj	machinery,of
R4328	T6924	T6925	compound	energy,supply
R4329	T6925	T6923	compound	supply,machinery
R4330	T6926	T6927	punct	[,43
R4331	T6927	T6910	parataxis	43,play
R4332	T6928	T6927	punct	],43
R4333	T6929	T6878	punct	.,add
R4334	T6931	T6932	nsubjpass	This,evidenced
R4335	T6933	T6932	auxpass	is,evidenced
R4336	T6934	T6932	advmod	further,evidenced
R4337	T6935	T6932	agent	by,evidenced
R4338	T6936	T6937	det	the,presence
R4339	T6937	T6935	pobj	presence,by
R4340	T6938	T6937	prep	of,presence
R4341	T6939	T6940	amod	genetic,modifiers
R4342	T6940	T6938	pobj	modifiers,of
R4343	T6941	T6937	prep	in,presence
R4344	T6942	T6943	nmod	RanBP2,mice
R4345	T6943	T6941	pobj	mice,in
R4346	T6944	T6942	punct	+,RanBP2
R4347	T6945	T6942	punct	/,RanBP2
R4348	T6946	T6942	punct	−,RanBP2
R4349	T6947	T6943	prep	on,mice
R4350	T6948	T6949	det	a,background
R4351	T6949	T6947	pobj	background,on
R4352	T6950	T6949	amod	mixed,background
R4353	T6951	T6949	amod	genetic,background
R4354	T6952	T6953	dep	that,compensates
R4355	T6953	T6949	relcl	compensates,background
R4356	T6954	T6953	prep	for,compensates
R4357	T6955	T6954	pobj	deficits,for
R4358	T6956	T6955	prep	in,deficits
R4359	T6957	T6956	pobj	RanBP2,in
R4360	T6958	T6955	cc	and,deficits
R4361	T6959	T6955	conj	deregulation,deficits
R4362	T6960	T6959	prep	of,deregulation
R4363	T6961	T6962	poss	its,partners
R4364	T6962	T6960	pobj	partners,of
R4365	T6963	T6962	prep	in,partners
R4366	T6964	T6965	compound	glucose,energy
R4367	T6965	T6967	compound	energy,homeostasis
R4368	T6966	T6965	punct	/,energy
R4369	T6967	T6963	pobj	homeostasis,in
R4370	T6968	T6969	mark	as,observed
R4371	T6969	T6953	advcl	observed,compensates
R4372	T6970	T6969	prep	in,observed
R4373	T6971	T6972	det	the,line
R4374	T6972	T6970	pobj	line,in
R4375	T6973	T6972	amod	coisogenic,line
R4376	T6974	T6932	punct	.,evidenced
R4377	T6976	T6977	det	The,presence
R4378	T6977	T6978	nsubjpass	presence,supported
R4379	T6979	T6977	prep	of,presence
R4380	T6980	T6981	amod	such,mechanisms
R4381	T6981	T6979	pobj	mechanisms,of
R4382	T6982	T6981	amod	compensatory,mechanisms
R4383	T6983	T6978	auxpass	is,supported
R4384	T6984	T6978	advmod	also,supported
R4385	T6985	T6978	agent	by,supported
R4386	T6986	T6987	det	the,identification
R4387	T6987	T6985	pobj	identification,by
R4388	T6988	T6987	prep	of,identification
R4389	T6989	T6990	det	a,locus
R4390	T6990	T6988	pobj	locus,of
R4391	T6991	T6990	amod	quantitative,locus
R4392	T6992	T6990	compound	trait,locus
R4393	T6993	T6990	punct	", ",locus
R4394	T6994	T6995	dep	which,encompasses
R4395	T6995	T6990	relcl	encompasses,locus
R4396	T6996	T6995	dobj	RanBP2,encompasses
R4397	T6997	T6978	punct	", ",supported
R4398	T6998	T6978	cc	and,supported
R4399	T6999	T6978	conj	modifies,supported
R4400	T7000	T7001	det	the,expression
R4401	T7001	T6999	dobj	expression,modifies
R4402	T7002	T7001	prep	of,expression
R4403	T7003	T7004	npadvmod	diabetes,related
R4404	T7004	T7006	amod	related,phenotypes
R4405	T7005	T7004	punct	-,related
R4406	T7006	T7002	pobj	phenotypes,of
R4407	T7007	T7008	punct	[,44
R4408	T7008	T6999	parataxis	44,modifies
R4409	T7009	T7008	punct	],44
R4410	T7010	T6978	punct	.,supported
R4411	T7012	T7013	det	The,data
R4412	T7013	T7014	nsubj	data,show
R4413	T7015	T7013	advmod	herein,data
R4414	T7016	T7014	dobj	tissues,show
R4415	T7017	T7016	prep	with,tissues
R4416	T7018	T7019	det	a,decrease
R4417	T7019	T7017	pobj	decrease,with
R4418	T7020	T7019	prep	of,decrease
R4419	T7021	T7020	pobj	RanBP2,of
R4420	T7022	T7014	cc	and,show
R4421	T7023	T7024	compound	HKI,levels
R4422	T7024	T7025	nsubj	levels,mirror
R4423	T7025	T7014	conj	mirror,show
R4424	T7026	T7027	det	a,reduction
R4425	T7027	T7025	dobj	reduction,mirror
R4426	T7028	T7027	prep	in,reduction
R4427	T7029	T7030	det	the,levels
R4428	T7030	T7028	pobj	levels,in
R4429	T7031	T7030	compound	ATP,levels
R4430	T7032	T7025	punct	.,mirror
R4431	T7034	T7035	mark	Since,consumes
R4432	T7035	T7065	advcl	consumes,underlies
R4433	T7036	T7037	det	the,pump
R4434	T7037	T7035	nsubj	pump,consumes
R4435	T7038	T7037	amod	constitutive,pump
R4436	T7039	T7040	compound	Na+,K+
R4437	T7040	T7037	compound	K+,pump
R4438	T7041	T7040	punct	/,K+
R4439	T7042	T7037	compound	ATPase,pump
R4440	T7043	T7037	cc	and,pump
R4441	T7044	T7045	det	the,conversion
R4442	T7045	T7037	conj	conversion,pump
R4443	T7046	T7047	npadvmod	ATP,dependent
R4444	T7047	T7045	amod	dependent,conversion
R4445	T7048	T7047	punct	-,dependent
R4446	T7049	T7045	prep	of,conversion
R4447	T7050	T7049	pobj	glutamine,of
R4448	T7051	T7045	prep	to,conversion
R4449	T7052	T7051	pobj	glutamate,to
R4450	T7053	T7035	punct	(,consumes
R4451	T7054	T7055	nsubj	both,fundamental
R4452	T7055	T7035	advcl	fundamental,consumes
R4453	T7056	T7057	aux	to,maintain
R4454	T7057	T7055	advcl	maintain,fundamental
R4455	T7058	T7059	det	the,activity
R4456	T7059	T7057	dobj	activity,maintain
R4457	T7060	T7059	amod	electrical,activity
R4458	T7061	T7057	prep	in,maintain
R4459	T7062	T7063	det	the,CNS
R4460	T7063	T7061	pobj	CNS,in
R4461	T7064	T7035	punct	),consumes
R4462	T7066	T7067	det	the,majority
R4463	T7067	T7035	dobj	majority,consumes
R4464	T7068	T7067	amod	vast,majority
R4465	T7069	T7067	prep	of,majority
R4466	T7070	T7071	det	the,energy
R4467	T7071	T7069	pobj	energy,of
R4468	T7072	T7071	acl	produced,energy
R4469	T7073	T7072	agent	by,produced
R4470	T7074	T7075	det	the,CNS
R4471	T7075	T7073	pobj	CNS,by
R4472	T7076	T7077	punct	[,45
R4473	T7077	T7035	parataxis	45,consumes
R4474	T7078	T7079	punct	–,47
R4475	T7079	T7077	prep	47,45
R4476	T7080	T7077	punct	],45
R4477	T7081	T7065	punct	", ",underlies
R4478	T7082	T7065	nsubj	this,underlies
R4479	T7083	T7065	advmod	likely,underlies
R4480	T7084	T7085	det	the,suppression
R4481	T7085	T7065	dobj	suppression,underlies
R4482	T7086	T7085	prep	of,suppression
R4483	T7087	T7088	det	the,responses
R4484	T7088	T7086	pobj	responses,of
R4485	T7089	T7090	amod	electrophysiological,output
R4486	T7090	T7088	compound	output,responses
R4487	T7091	T7088	prep	of,responses
R4488	T7092	T7093	amod	retinal,neurons
R4489	T7093	T7091	pobj	neurons,of
R4490	T7094	T7095	punct	(,Figure
R4491	T7095	T7065	parataxis	Figure,underlies
R4492	T7096	T7095	nummod	8,Figure
R4493	T7097	T7095	punct	),Figure
R4494	T7098	T7065	punct	.,underlies
R4495	T7100	T7101	advmod	Moreover,lead
R4496	T7102	T7101	punct	", ",lead
R4497	T7103	T7101	nsubj	deficits,lead
R4498	T7104	T7103	prep	in,deficits
R4499	T7105	T7104	pobj	HKI,in
R4500	T7106	T7101	aux	may,lead
R4501	T7107	T7101	prep	to,lead
R4502	T7108	T7109	amod	intracellular,hyperglycemia
R4503	T7109	T7107	pobj	hyperglycemia,to
R4504	T7110	T7101	prep	in,lead
R4505	T7111	T7112	det	the,CNS
R4506	T7112	T7110	pobj	CNS,in
R4507	T7113	T7101	punct	", ",lead
R4508	T7114	T7101	conj	promote,lead
R4509	T7115	T7116	npadvmod	sorbitol,induced
R4510	T7116	T7118	amod	induced,stress
R4511	T7117	T7116	punct	-,induced
R4512	T7118	T7114	dobj	stress,promote
R4513	T7119	T7118	amod	osmotic,stress
R4514	T7120	T7114	punct	", ",promote
R4515	T7121	T7114	cc	and,promote
R4516	T7122	T7114	conj	compromise,promote
R4517	T7123	T7122	advmod	further,compromise
R4518	T7124	T7125	det	the,activity
R4519	T7125	T7122	dobj	activity,compromise
R4520	T7126	T7127	npadvmod	ATPase,dependent
R4521	T7127	T7125	amod	dependent,activity
R4522	T7128	T7127	punct	-,dependent
R4523	T7129	T7130	compound	Na+,K+
R4524	T7130	T7125	compound	K+,activity
R4525	T7131	T7130	punct	/,K+
R4526	T7132	T7125	compound	pump,activity
R4527	T7133	T7134	punct	[,48
R4528	T7134	T7122	parataxis	48,compromise
R4529	T7135	T7136	punct	–,50
R4530	T7136	T7134	prep	50,48
R4531	T7137	T7134	punct	],48
R4532	T7138	T7101	punct	.,lead
R4533	T7140	T7141	nsubjpass	This,exacerbated
R4534	T7142	T7141	aux	may,exacerbated
R4535	T7143	T7141	auxpass	be,exacerbated
R4536	T7144	T7141	agent	by,exacerbated
R4537	T7145	T7146	det	a,decrease
R4538	T7146	T7144	pobj	decrease,by
R4539	T7147	T7146	prep	of,decrease
R4540	T7148	T7147	pobj	ATP,of
R4541	T7149	T7141	punct	", ",exacerbated
R4542	T7150	T7151	mark	since,stimulated
R4543	T7151	T7141	advcl	stimulated,exacerbated
R4544	T7152	T7153	det	the,activity
R4545	T7153	T7151	nsubjpass	activity,stimulated
R4546	T7154	T7153	prep	of,activity
R4547	T7155	T7154	pobj	HKI,of
R4548	T7156	T7151	auxpass	is,stimulated
R4549	T7157	T7151	advmod	also,stimulated
R4550	T7158	T7151	agent	by,stimulated
R4551	T7159	T7158	pobj	ATP,by
R4552	T7160	T7161	punct	[,51
R4553	T7161	T7151	parataxis	51,stimulated
R4554	T7162	T7161	punct	],51
R4555	T7163	T7141	punct	.,exacerbated
R4556	T7165	T7166	det	The,effects
R4557	T7166	T7168	nsubjpass	effects,known
R4558	T7167	T7166	amod	cumulative,effects
R4559	T7169	T7166	prep	of,effects
R4560	T7170	T7171	det	a,reduction
R4561	T7171	T7169	pobj	reduction,of
R4562	T7172	T7171	prep	in,reduction
R4563	T7173	T7172	pobj	ATP,in
R4564	T7174	T7171	cc	and,reduction
R4565	T7175	T7176	amod	intracellular,hyperglycemia
R4566	T7176	T7171	conj	hyperglycemia,reduction
R4567	T7177	T7168	auxpass	are,known
R4568	T7178	T7179	aux	to,act
R4569	T7179	T7168	xcomp	act,known
R4570	T7180	T7179	advmod	synergistically,act
R4571	T7181	T7179	cc	and,act
R4572	T7182	T7179	conj	modulate,act
R4573	T7183	T7184	det	the,properties
R4574	T7184	T7182	dobj	properties,modulate
R4575	T7185	T7184	amod	electrophysiological,properties
R4576	T7186	T7184	prep	of,properties
R4577	T7187	T7188	amod	neuronal,activity
R4578	T7188	T7186	pobj	activity,of
R4579	T7189	T7168	punct	.,known
R4580	T7191	T7192	nsubj	Figure,integrates
R4581	T7193	T7191	nummod	9,Figure
R4582	T7194	T7192	prep	in,integrates
R4583	T7195	T7196	det	a,model
R4584	T7196	T7194	pobj	model,in
R4585	T7197	T7198	det	these,variables
R4586	T7198	T7192	dobj	variables,integrates
R4587	T7199	T7198	cc	and,variables
R4588	T7200	T7198	conj	implications,variables
R4589	T7201	T7200	prep	of,implications
R4590	T7202	T7203	det	the,data
R4591	T7203	T7201	pobj	data,of
R4592	T7204	T7203	acl	presented,data
R4593	T7205	T7204	advmod	herein,presented
R4594	T7206	T7192	punct	.,integrates
R4595	T7208	T7209	advmod	Still,become
R4596	T7210	T7209	punct	", ",become
R4597	T7211	T7212	amod	other,partners
R4598	T7212	T7209	nsubj	partners,become
R4599	T7213	T7214	advmod	bona,fide
R4600	T7214	T7212	amod	fide,partners
R4601	T7215	T7212	compound	RanBP2,partners
R4602	T7216	T7217	advmod	previously,identified
R4603	T7217	T7212	acl	identified,partners
R4604	T7218	T7217	cc	and,identified
R4605	T7219	T7217	conj	described,identified
R4606	T7220	T7219	prep	in,described
R4607	T7221	T7222	det	the,Introduction
R4608	T7222	T7220	pobj	Introduction,in
R4609	T7223	T7209	advmod	also,become
R4610	T7224	T7225	amod	strong,candidates
R4611	T7225	T7209	attr	candidates,become
R4612	T7226	T7227	aux	to,play
R4613	T7227	T7225	advcl	play,candidates
R4614	T7228	T7229	det	a,role
R4615	T7229	T7227	dobj	role,play
R4616	T7230	T7227	prep	in,play
R4617	T7231	T7232	compound	energy,homeostasis
R4618	T7232	T7230	pobj	homeostasis,in
R4619	T7233	T7209	punct	.,become
R4620	T7235	T7236	prep	For,modulated
R4621	T7274	T7267	punct	),degradation
R4622	T7237	T7235	pobj	example,For
R4623	T7275	T7276	punct	[,43
R4624	T7276	T7264	parataxis	43,contribute
R4625	T7238	T7236	punct	", ",modulated
R4626	T7277	T7276	punct	],43
R4627	T7278	T7236	punct	", ",modulated
R4628	T7239	T7240	det	the,activity
R4629	T7279	T7280	mark	while,mediate
R4630	T7280	T7236	advcl	mediate,modulated
R4631	T7281	T7280	nsubj	association,mediate
R4632	T7282	T7281	prep	of,association
R4633	T7283	T7284	amod	nuclear,receptor
R4634	T7284	T7282	pobj	receptor,of
R4635	T7240	T7236	nsubjpass	activity,modulated
R4636	T7285	T7284	compound	import,receptor
R4637	T7286	T7284	punct	", ",receptor
R4638	T7287	T7288	compound	importin,β
R4639	T7241	T7242	amod	unfolding,chaperone
R4640	T7288	T7284	appos	β,receptor
R4641	T7289	T7288	punct	-,β
R4642	T7290	T7281	prep	with,association
R4643	T7242	T7240	compound	chaperone,activity
R4644	T7291	T7292	det	the,domains
R4645	T7292	T7290	pobj	domains,with
R4646	T7293	T7294	npadvmod	Ran,binding
R4647	T7243	T7242	cc	and,chaperone
R4648	T7294	T7292	amod	binding,domains
R4649	T7295	T7294	punct	-,binding
R4650	T7244	T7240	prep	of,activity
R4651	T7296	T7292	prep	of,domains
R4652	T7297	T7296	pobj	RanBP2,of
R4653	T7298	T7299	punct	[,11
R4654	T7245	T7244	pobj	components,of
R4655	T7299	T7281	parataxis	11,association
R4656	T7300	T7299	nummod	10,11
R4657	T7301	T7299	punct	",",11
R4658	T7246	T7245	prep	of,components
R4659	T7302	T7299	punct	],11
R4660	T7303	T7280	punct	", ",mediate
R4661	T7247	T7248	det	the,cap
R4662	T7304	T7280	aux	may,mediate
R4663	T7305	T7306	det	the,translocation
R4664	T7306	T7280	dobj	translocation,mediate
R4665	T7307	T7306	amod	nuclear,translocation
R4666	T7248	T7246	pobj	cap,of
R4667	T7308	T7306	prep	of,translocation
R4668	T7309	T7310	amod	multifunctional,substrates
R4669	T7249	T7248	compound	19S,cap
R4670	T7310	T7308	pobj	substrates,of
R4671	T7311	T7310	punct	", ",substrates
R4672	T7312	T7313	amod	such,as
R4673	T7250	T7248	prep	of,cap
R4674	T7313	T7310	prep	as,substrates
R4675	T7314	T7315	nmod	glyceraldehyde,phosphate
R4676	T7251	T7252	det	the,proteasome
R4677	T7315	T7319	compound	phosphate,dehydrogenase
R4678	T7252	T7250	pobj	proteasome,of
R4679	T7316	T7315	punct	-,phosphate
R4680	T7317	T7315	nummod	3,phosphate
R4681	T7318	T7315	punct	-,phosphate
R4682	T7319	T7313	pobj	dehydrogenase,as
R4683	T7320	T7236	punct	.,modulated
R4684	T7253	T7236	aux	may,modulated
R4685	T7322	T7323	det	This,process
R4686	T7323	T7325	nsubjpass	process,inhibited
R4687	T7254	T7236	auxpass	be,modulated
R4688	T7324	T7323	compound	trafficking,process
R4689	T7326	T7325	auxpass	is,inhibited
R4690	T7255	T7236	agent	by,modulated
R4691	T7327	T7325	advmod	selectively,inhibited
R4692	T7328	T7325	agent	by,inhibited
R4693	T7329	T7330	det	the,drug
R4694	T7256	T7257	det	the,CLD
R4695	T7330	T7328	pobj	drug,by
R4696	T7331	T7330	amod	neuroprotective,drug
R4697	T7332	T7330	punct	", ",drug
R4698	T7257	T7255	pobj	CLD,by
R4699	T7333	T7334	nmod	R,deprenyl
R4700	T7334	T7330	appos	deprenyl,drug
R4701	T7258	T7257	prep	of,CLD
R4702	T7335	T7333	punct	-,R
R4703	T7336	T7333	punct	(,R
R4704	T7337	T7333	punct	-,R
R4705	T7259	T7258	pobj	RanBP2,of
R4706	T7338	T7333	punct	),R
R4707	T7339	T7333	punct	-,R
R4708	T7260	T7261	punct	[,14
R4709	T7340	T7330	cc	and,drug
R4710	T7341	T7330	conj	derivates,drug
R4711	T7342	T7341	advmod	thereof,derivates
R4712	T7261	T7236	parataxis	14,modulated
R4713	T7343	T7325	punct	", ",inhibited
R4714	T7344	T7325	cc	and,inhibited
R4715	T7262	T7261	punct	],14
R4716	T7345	T7346	auxpass	are,employed
R4717	T7346	T7325	conj	employed,inhibited
R4718	T7347	T7346	advmod	often,employed
R4719	T7263	T7236	cc	and,modulated
R4720	T7348	T7349	aux	to,treat
R4721	T7349	T7346	advcl	treat,employed
R4722	T7350	T7351	compound	Parkinson,disease
R4723	T7264	T7236	conj	contribute,modulated
R4724	T7351	T7349	dobj	disease,treat
R4725	T7352	T7353	punct	[,52
R4726	T7353	T7346	parataxis	52,employed
R4727	T7265	T7264	prep	to,contribute
R4728	T7354	T7355	punct	–,57
R4729	T7355	T7353	prep	57,52
R4730	T7356	T7353	punct	],52
R4731	T7266	T7267	det	the,degradation
R4732	T7357	T7325	punct	.,inhibited
R4733	T7359	T7360	advmod	Hence,emerge
R4734	T7361	T7360	punct	", ",emerge
R4735	T7267	T7265	pobj	degradation,to
R4736	T7362	T7360	nsubj	RanBP2,emerge
R4737	T7363	T7362	cc	and,RanBP2
R4738	T7364	T7365	poss	its,partners
R4739	T7268	T7267	amod	selective,degradation
R4740	T7365	T7362	conj	partners,RanBP2
R4741	T7366	T7360	prep	as,emerge
R4742	T7367	T7368	amod	key,players
R4743	T7269	T7267	nmod	HKI,degradation
R4744	T7368	T7366	pobj	players,as
R4745	T7270	T7269	punct	(,HKI
R4746	T7271	T7269	cc	and,HKI
R4747	T7369	T7368	cc	and,players
R4748	T7370	T7371	compound	target,genes
R4749	T7371	T7368	conj	genes,players
R4750	T7272	T7273	amod	other,substrates
R4751	T7372	T7360	prep	in,emerge
R4752	T7373	T7372	pcomp	mediating,in
R4753	T7374	T7375	amod	neuropathophysiological,mechanisms
R4754	T7273	T7269	conj	substrates,HKI
R4755	T7375	T7373	dobj	mechanisms,mediating
R4756	T7376	T7375	acl	implicated,mechanisms
R4757	T7377	T7376	prep	in,implicated
R4758	T7379	T7377	pobj	lesions,in
R4759	T7378	T7379	amod	various,lesions
R4760	T7380	T7379	amod	genetic,lesions
R4761	T7381	T7380	cc	and,genetic
R4762	T7382	T7380	conj	environmental,genetic
R4763	T7383	T7379	prep	to,lesions
R4764	T7384	T7385	det	the,CNS
R4765	T7385	T7383	pobj	CNS,to
R4766	T7455	T7456	advmod	"Figure 9 Model Depicting a Role of RanBP2 and Some of Its Partners in Metabolic and Neuronal Function RanBP2 interacts with Cox11 and HKI and the triad is in equilibrium under normal physiological conditions. RanBP2 prevents the inhibition of HKI by Cox11 and its degradation. The ultimate effect of RanBP2 on its partners is the stimulation of the glycolytic pathway and production of ATP. The glycolytic pathway is critical to fuel the constitutive Na+/K+-ATPase pump to maintain the dark current between the inner and outer segment compartments of photosensory neurons. A deficit (haploinsufficiency) in RanBP2 disturbs the equilibrium between RanBP2, HKI, and Cox11. This pathophysiological event promotes the destabilization and degradation of HKI and a decrease in ATP production required to maintain the depolarization state neurons, and, hence, a reduction in the response of receptoral and postreceptoral neurons. A reduction in ATP levels also negatively modulates HKI activity/level. Decreased levels of HKI promote intracellular hyperglycemia and activate stress kinases, which modulate negatively the Na+/K+-ATPase pump by phosphorylation. Pathophysiological pathways promoted by RanBP2 haploinsufficiency are represented by dash lines. RIS, rod inner segment; ROS, rod outer segment. Finally",appears
R4767	T7386	T7379	punct	", ",lesions
R4768	T7457	T7456	punct	", ",appears
R4769	T7458	T7456	nsubj	RanBP2,appears
R4770	T7387	T7379	prep	as,lesions
R4771	T7459	T7460	aux	to,join
R4772	T7460	T7456	xcomp	join,appears
R4773	T7388	T7387	prep	in,as
R4774	T7461	T7462	amod	other,nucleoporins
R4775	T7462	T7460	dobj	nucleoporins,join
R4776	T7463	T7462	punct	", ",nucleoporins
R4777	T7389	T7388	pobj	patients,in
R4778	T7464	T7465	amod	such,as
R4779	T7390	T7389	prep	with,patients
R4780	T7465	T7462	prep	as,nucleoporins
R4781	T7466	T7465	pobj	Nup96,as
R4782	T7467	T7468	punct	[,58
R4783	T7391	T7390	pobj	Parkinson,with
R4784	T7392	T7391	punct	", ",Parkinson
R4785	T7393	T7391	conj	diabetes,Parkinson
R4786	T7468	T7460	parataxis	58,join
R4787	T7469	T7468	punct	],58
R4788	T7470	T7460	punct	", ",join
R4789	T7394	T7393	prep	with,diabetes
R4790	T7471	T7460	prep	in,join
R4791	T7472	T7473	amod	novel,functions
R4792	T7473	T7471	pobj	functions,in
R4793	T7395	T7396	compound	insulin,resistance
R4794	T7474	T7473	amod	physiological,functions
R4795	T7475	T7476	dep	that,are
R4796	T7476	T7473	advcl	are,functions
R4797	T7396	T7394	pobj	resistance,with
R4798	T7477	T7476	acomp	vital,are
R4799	T7478	T7477	prep	for,vital
R4800	T7397	T7396	punct	-,resistance
R4801	T7479	T7480	amod	complex,organisms
R4802	T7480	T7478	pobj	organisms,for
R4803	T7481	T7476	cc	and,are
R4804	T7398	T7393	punct	", ",diabetes
R4805	T7482	T7483	dep	that,anticipated
R4806	T7483	T7476	conj	anticipated,are
R4807	T7484	T7483	auxpass	were,anticipated
R4808	T7399	T7393	cc	and,diabetes
R4809	T7485	T7483	neg	not,anticipated
R4810	T7486	T7483	prep	from,anticipated
R4811	T7487	T7488	npadvmod	cell,based
R4812	T7400	T7401	amod	other,neuropathies
R4813	T7488	T7490	amod	based,studies
R4814	T7489	T7488	punct	-,based
R4815	T7490	T7486	pobj	studies,from
R4816	T7401	T7393	conj	neuropathies,diabetes
R4817	T7491	T7456	punct	.,appears
R4818	T7402	T7401	cc	and,neuropathies
R4819	T7493	T7494	det	The,expression
R4820	T7494	T7496	nsubj	expression,generates
R4821	T7495	T7494	amod	reduced,expression
R4822	T7403	T7404	amod	neurodegenerative,diseases
R4823	T7497	T7494	prep	of,expression
R4824	T7404	T7401	conj	diseases,neuropathies
R4825	T7498	T7499	det	these,proteins
R4826	T7499	T7497	pobj	proteins,of
R4827	T7405	T7401	punct	", ",neuropathies
R4828	T7500	T7494	prep	in,expression
R4829	T7501	T7502	amod	whole,animal
R4830	T7502	T7504	compound	animal,models
R4831	T7406	T7407	advmod	often,linked
R4832	T7503	T7502	punct	-,animal
R4833	T7504	T7500	pobj	models,in
R4834	T7407	T7401	acl	linked,neuropathies
R4835	T7505	T7496	dobj	phenotypes,generates
R4836	T7506	T7507	dep	that,are
R4837	T7507	T7505	relcl	are,phenotypes
R4838	T7508	T7509	npadvmod	tissue,restricted
R4839	T7509	T7507	acomp	restricted,are
R4840	T7510	T7509	punct	-,restricted
R4841	T7408	T7407	prep	to,linked
R4842	T7511	T7507	cc	and,are
R4843	T7512	T7513	advmod	more,importantly
R4844	T7513	T7514	advmod	importantly,seem
R4845	T7514	T7507	conj	seem,are
R4846	T7409	T7410	compound	aging,manifestations
R4847	T7515	T7514	punct	", ",seem
R4848	T7516	T7514	aux	do,seem
R4849	T7517	T7514	neg	not,seem
R4850	T7410	T7408	pobj	manifestations,to
R4851	T7518	T7519	aux	to,recapitulate
R4852	T7519	T7514	xcomp	recapitulate,seem
R4853	T7411	T7360	punct	.,emerge
R4854	T7520	T7519	dobj	phenotypes,recapitulate
R4855	T7521	T7520	acl	observed,phenotypes
R4856	T7522	T7521	prep	with,observed
R4857	T7523	T7524	compound	knockdown,experiments
R4858	T7413	T7414	prep	To,serve
R4859	T7524	T7522	pobj	experiments,with
R4860	T7525	T7524	prep	in,experiments
R4861	T7526	T7527	npadvmod	cell,based
R4862	T7415	T7416	det	this,effect
R4863	T7416	T7413	pobj	effect,To
R4864	T7527	T7529	amod	based,assays
R4865	T7528	T7527	punct	-,based
R4866	T7529	T7525	pobj	assays,in
R4867	T7417	T7414	punct	", ",serve
R4868	T7530	T7529	compound	culture,assays
R4869	T7531	T7496	punct	.,generates
R4870	T7418	T7419	det	the,model
R4871	T7533	T7534	prep	For,shown
R4872	T7419	T7414	nsubj	model,serve
R4873	T7535	T7533	pobj	example,For
R4874	T7536	T7534	punct	", ",shown
R4875	T7537	T7538	amod	short,knockdown
R4876	T7420	T7419	compound	RanBP2,model
R4877	T7421	T7419	compound	mouse,model
R4878	T7538	T7534	nsubj	knockdown,shown
R4879	T7422	T7414	aux	will,serve
R4880	T7539	T7538	amod	interfering,knockdown
R4881	T7540	T7541	npadvmod	RNA,mediated
R4882	T7423	T7414	prep	as,serve
R4883	T7541	T7538	amod	mediated,knockdown
R4884	T7542	T7541	punct	-,mediated
R4885	T7543	T7538	prep	of,knockdown
R4886	T7424	T7425	det	a,tool
R4887	T7544	T7543	pobj	RanBP2,of
R4888	T7545	T7546	punct	[,9
R4889	T7546	T7538	parataxis	9,knockdown
R4890	T7547	T7546	punct	],9
R4891	T7548	T7538	cc	and,knockdown
R4892	T7425	T7423	pobj	tool,as
R4893	T7549	T7538	conj	members,knockdown
R4894	T7550	T7549	prep	of,members
R4895	T7551	T7552	det	the,complex
R4896	T7426	T7425	amod	unique,tool
R4897	T7552	T7550	pobj	complex,of
R4898	T7553	T7554	compound	Nup107,Nup160
R4899	T7554	T7552	compound	Nup160,complex
R4900	T7427	T7425	amod	genetic,tool
R4901	T7555	T7554	punct	-,Nup160
R4902	T7556	T7557	punct	[,59
R4903	T7557	T7549	parataxis	59,members
R4904	T7428	T7429	aux	to,probe
R4905	T7558	T7559	punct	–,61
R4906	T7559	T7557	prep	61,59
R4907	T7560	T7557	punct	],59
R4908	T7429	T7425	advcl	probe,tool
R4909	T7561	T7534	aux	have,shown
R4910	T7562	T7534	punct	", ",shown
R4911	T7563	T7534	advmod	respectively,shown
R4912	T7430	T7431	amod	selective,pathways
R4913	T7564	T7534	punct	", ",shown
R4914	T7565	T7566	aux	to,cause
R4915	T7566	T7534	xcomp	cause,shown
R4916	T7431	T7429	dobj	pathways,probe
R4917	T7567	T7568	amod	mitotic,arrest
R4918	T7568	T7566	dobj	arrest,cause
R4919	T7432	T7430	punct	", ",selective
R4920	T7569	T7568	cc	and,arrest
R4921	T7570	T7568	conj	disruption,arrest
R4922	T7571	T7570	prep	of,disruption
R4923	T7433	T7430	conj	multiple,selective
R4924	T7572	T7573	amod	nuclear,pore
R4925	T7573	T7574	compound	pore,assembly
R4926	T7434	T7433	cc	and,multiple
R4927	T7435	T7433	conj	novel,multiple
R4928	T7436	T7431	punct	", ",pathways
R4929	T7574	T7571	pobj	assembly,of
R4930	T7575	T7570	cc	and,disruption
R4931	T7437	T7438	dep	which,anticipated
R4932	T7576	T7570	conj	deficits,disruption
R4933	T7577	T7576	prep	in,deficits
R4934	T7438	T7431	relcl	anticipated,pathways
R4935	T7578	T7579	compound	mRNA,export
R4936	T7579	T7577	pobj	export,in
R4937	T7580	T7566	prep	in,cause
R4938	T7439	T7438	aux	may,anticipated
R4939	T7581	T7582	compound	cell,culture
R4940	T7582	T7580	pobj	culture,in
R4941	T7583	T7534	punct	.,shown
R4942	T7585	T7586	advmod	Yet,produce
R4943	T7440	T7438	aux	have,anticipated
R4944	T7587	T7586	punct	", ",produce
R4945	T7588	T7586	nsubj	haploinsufficiency,produce
R4946	T7441	T7438	neg	not,anticipated
R4947	T7589	T7588	prep	of,haploinsufficiency
R4948	T7590	T7589	pobj	RanBP2,of
R4949	T7591	T7592	punct	(,work
R4950	T7442	T7438	auxpass	been,anticipated
R4951	T7592	T7590	parataxis	work,RanBP2
R4952	T7593	T7592	det	this,work
R4953	T7594	T7592	punct	),work
R4954	T7443	T7444	aux	to,linked
R4955	T7595	T7590	cc	and,RanBP2
R4956	T7596	T7590	conj	Nup96,RanBP2
R4957	T7597	T7598	punct	[,58
R4958	T7444	T7438	xcomp	linked,anticipated
R4959	T7598	T7596	parataxis	58,Nup96
R4960	T7599	T7598	punct	],58
R4961	T7600	T7586	advmod	predominantly,produce
R4962	T7445	T7444	auxpass	be,linked
R4963	T7601	T7586	punct	", ",produce
R4964	T7602	T7586	advmod	instead,produce
R4965	T7603	T7586	punct	", ",produce
R4966	T7446	T7444	prep	to,linked
R4967	T7604	T7605	npadvmod	CNS,restricted
R4968	T7605	T7607	amod	restricted,deficits
R4969	T7606	T7605	punct	-,restricted
R4970	T7447	T7448	amod	metabolic,processes
R4971	T7607	T7586	dobj	deficits,produce
R4972	T7608	T7607	prep	in,deficits
R4973	T7609	T7610	compound	energy,metabolism
R4974	T7448	T7446	pobj	processes,to
R4975	T7610	T7608	pobj	metabolism,in
R4976	T7611	T7607	cc	and,deficits
R4977	T7449	T7448	cc	and,processes
R4978	T7612	T7607	conj	alterations,deficits
R4979	T7450	T7451	amod	allied,states
R4980	T7613	T7612	prep	in,alterations
R4981	T7614	T7615	det	the,system
R4982	T7451	T7448	conj	states,processes
R4983	T7615	T7613	pobj	system,in
R4984	T7616	T7615	amod	immune,system
R4985	T7617	T7612	acl	linked,alterations
R4986	T7452	T7451	amod	pathophysiological,states
R4987	T7618	T7617	prep	to,linked
R4988	T7619	T7620	det	the,regulation
R4989	T7453	T7414	punct	.,serve
R4990	T7620	T7618	pobj	regulation,to
R4991	T7621	T7620	amod	down,regulation
R4992	T7622	T7620	punct	-,regulation
R4993	T7623	T7620	prep	of,regulation
R4994	T7624	T7625	compound	interferon,β
R4995	T7625	T7627	npadvmod	β,regulated
R4996	T7680	T7670	dobj	stage,set
R4997	T7626	T7625	punct	-,β
R4998	T7627	T7629	amod	regulated,proteins
R4999	T7628	T7627	punct	-,regulated
R5000	T7629	T7623	pobj	proteins,of
R5001	T7630	T7620	cc	and,regulation
R5002	T7681	T7682	aux	to,probe
R5003	T7631	T7632	amod	increased,susceptibility
R5004	T7632	T7620	conj	susceptibility,regulation
R5005	T7633	T7632	prep	of,susceptibility
R5006	T7682	T7670	advcl	probe,set
R5007	T7634	T7635	amod	viral,infection
R5008	T7635	T7633	pobj	infection,of
R5009	T7636	T7617	punct	", ",linked
R5010	T7683	T7684	amod	novel,pathways
R5011	T7637	T7617	advmod	respectively,linked
R5012	T7638	T7586	punct	.,produce
R5013	T7684	T7682	dobj	pathways,probe
R5014	T7640	T7641	mark	While,remain
R5015	T7641	T7649	advcl	remain,result
R5016	T7685	T7684	amod	molecular,pathways
R5017	T7642	T7643	det	these,disparities
R5018	T7643	T7641	nsubj	disparities,remain
R5019	T7644	T7643	amod	apparent,disparities
R5020	T7686	T7682	prep	in,probe
R5021	T7645	T7643	compound	outcome,disparities
R5022	T7646	T7643	prep	among,disparities
R5023	T7647	T7648	amod	experimental,systems
R5024	T7687	T7688	amod	various,contexts
R5025	T7648	T7646	pobj	systems,among
R5026	T7650	T7641	acomp	unclear,remain
R5027	T7688	T7686	pobj	contexts,in
R5028	T7651	T7649	punct	", ",result
R5029	T7652	T7649	nsubj	they,result
R5030	T7653	T7649	aux	could,result
R5031	T7689	T7688	amod	physiological,contexts
R5032	T7654	T7649	advmod	potentially,result
R5033	T7655	T7649	prep	from,result
R5034	T7656	T7655	pobj	variations,from
R5035	T7690	T7689	cc	and,physiological
R5036	T7657	T7656	prep	in,variations
R5037	T7658	T7657	pobj	redundancies,in
R5038	T7691	T7689	conj	genetic,physiological
R5039	T7659	T7658	cc	and,redundancies
R5040	T7660	T7661	amod	compensatory,mechanisms
R5041	T7661	T7658	conj	mechanisms,redundancies
R5042	T7662	T7658	amod	inherent,redundancies
R5043	T7692	T7682	punct	", ",probe
R5044	T7663	T7662	prep	to,inherent
R5045	T7664	T7665	det	each,system
R5046	T7665	T7663	pobj	system,to
R5047	T7666	T7665	amod	experimental,system
R5048	T7667	T7649	punct	.,result
R5049	T7693	T7682	cc	and,probe
R5050	T7669	T7670	advmod	Regardless,set
R5051	T7694	T7682	conj	provide,probe
R5052	T7671	T7670	punct	", ",set
R5053	T7672	T7673	det	these,models
R5054	T7673	T7670	nsubj	models,set
R5055	T7695	T7694	advmod	also,provide
R5056	T7674	T7673	amod	genetic,models
R5057	T7675	T7674	cc	and,genetic
R5058	T7676	T7677	amod	whole,animal
R5059	T7696	T7697	det	a,link
R5060	T7677	T7674	conj	animal,genetic
R5061	T7678	T7677	punct	-,animal
R5062	T7679	T7680	det	the,stage
R5063	T7697	T7694	dobj	link,provide
R5064	T7698	T7697	prep	to,link
R5065	T7699	T7700	amod	pathophysiological,processes
R5066	T7700	T7698	pobj	processes,to
R5067	T7701	T7700	acl	underlying,processes
R5068	T7702	T7703	amod	several,diseases
R5069	T7703	T7701	dobj	diseases,underlying
R5070	T7704	T7703	amod	human,diseases
R5071	T7705	T7670	punct	.,set
R9536	T14526	T14525	acl	Depicting,Model
R9537	T14527	T14528	det	a,Role
R9538	T14528	T14526	dobj	Role,Depicting
R9539	T14529	T14528	prep	of,Role
R9540	T14530	T14529	pobj	RanBP2,of
R9541	T14531	T14530	cc	and,RanBP2
R9542	T14532	T14530	conj	Some,RanBP2
R9543	T14533	T14532	prep	of,Some
R9544	T14534	T14535	poss	Its,Partners
R9545	T14535	T14533	pobj	Partners,of
R9546	T14536	T14528	prep	in,Role
R9547	T14537	T14538	amod	Metabolic,Function
R9548	T14538	T14536	pobj	Function,in
R9549	T14539	T14537	cc	and,Metabolic
R9550	T14540	T14537	conj	Neuronal,Metabolic
R9551	T14542	T14543	nsubj	RanBP2,interacts
R9552	T14544	T14543	prep	with,interacts
R9553	T14545	T14544	pobj	Cox11,with
R9554	T14546	T14545	cc	and,Cox11
R9555	T14547	T14545	conj	HKI,Cox11
R9556	T14548	T14543	cc	and,interacts
R9557	T14549	T14550	det	the,triad
R9558	T14550	T14551	nsubj	triad,is
R9559	T14551	T14543	conj	is,interacts
R9560	T14552	T14551	prep	in,is
R9561	T14553	T14552	pobj	equilibrium,in
R9562	T14554	T14551	prep	under,is
R9563	T14555	T14556	amod	normal,conditions
R9564	T14556	T14554	pobj	conditions,under
R9565	T14557	T14556	amod	physiological,conditions
R9566	T14558	T14551	punct	.,is
R9567	T14560	T14561	nsubj	RanBP2,prevents
R9568	T14562	T14563	det	the,inhibition
R9569	T14563	T14561	dobj	inhibition,prevents
R9570	T14564	T14563	prep	of,inhibition
R9571	T14565	T14564	pobj	HKI,of
R9572	T14566	T14563	prep	by,inhibition
R9573	T14567	T14566	pobj	Cox11,by
R9574	T14568	T14567	cc	and,Cox11
R9575	T14569	T14570	poss	its,degradation
R9576	T14570	T14567	conj	degradation,Cox11
R9577	T14571	T14561	punct	.,prevents
R9578	T14573	T14574	det	The,effect
R9579	T14574	T14576	nsubj	effect,is
R9580	T14575	T14574	amod	ultimate,effect
R9581	T14577	T14574	prep	of,effect
R9582	T14578	T14577	pobj	RanBP2,of
R9583	T14579	T14574	prep	on,effect
R9584	T14580	T14581	poss	its,partners
R9585	T14581	T14579	pobj	partners,on
R9586	T14582	T14583	det	the,stimulation
R9587	T14583	T14576	attr	stimulation,is
R9588	T14584	T14583	prep	of,stimulation
R9589	T14585	T14586	det	the,pathway
R9590	T14586	T14584	pobj	pathway,of
R9591	T14587	T14586	amod	glycolytic,pathway
R9592	T14588	T14583	cc	and,stimulation
R9593	T14589	T14583	conj	production,stimulation
R9594	T14590	T14589	prep	of,production
R9595	T14591	T14590	pobj	ATP,of
R9596	T14592	T14576	punct	.,is
R9597	T14594	T14595	det	The,pathway
R9598	T14595	T14597	nsubj	pathway,is
R9599	T14596	T14595	amod	glycolytic,pathway
R9600	T14598	T14597	acomp	critical,is
R9601	T14599	T14600	aux	to,fuel
R9602	T14600	T14597	advcl	fuel,is
R9603	T14601	T14602	det	the,pump
R9604	T14602	T14600	dobj	pump,fuel
R9605	T14603	T14602	amod	constitutive,pump
R9606	T14604	T14605	nmod	Na+,K+
R9607	T14605	T14607	compound	K+,ATPase
R9608	T14606	T14605	punct	/,K+
R9609	T14607	T14602	compound	ATPase,pump
R9610	T14608	T14607	punct	-,ATPase
R9611	T14609	T14610	aux	to,maintain
R9612	T14610	T14600	advcl	maintain,fuel
R9613	T14611	T14612	det	the,current
R9614	T14612	T14610	dobj	current,maintain
R9615	T14613	T14612	amod	dark,current
R9616	T14614	T14612	prep	between,current
R9617	T14615	T14616	det	the,compartments
R9618	T14616	T14614	pobj	compartments,between
R9619	T14617	T14616	amod	inner,compartments
R9620	T14618	T14617	cc	and,inner
R9621	T14619	T14617	conj	outer,inner
R9622	T14620	T14616	compound	segment,compartments
R9623	T14621	T14616	prep	of,compartments
R9624	T14622	T14623	amod	photosensory,neurons
R9625	T14623	T14621	pobj	neurons,of
R9626	T14624	T14597	punct	.,is
R9627	T14626	T14627	det	A,deficit
R9628	T14627	T14628	nsubj	deficit,disturbs
R9629	T14629	T14627	punct	(,deficit
R9630	T14630	T14627	appos	haploinsufficiency,deficit
R9631	T14631	T14627	punct	),deficit
R9632	T14632	T14627	prep	in,deficit
R9633	T14633	T14632	pobj	RanBP2,in
R9634	T14634	T14635	det	the,equilibrium
R9635	T14635	T14628	dobj	equilibrium,disturbs
R9636	T14636	T14635	prep	between,equilibrium
R9637	T14637	T14636	pobj	RanBP2,between
R9638	T14638	T14637	punct	", ",RanBP2
R9639	T14639	T14637	conj	HKI,RanBP2
R9640	T14640	T14639	punct	", ",HKI
R9641	T14641	T14639	cc	and,HKI
R9642	T14642	T14639	conj	Cox11,HKI
R9643	T14643	T14628	punct	.,disturbs
R9644	T14645	T14646	det	This,event
R9645	T14646	T14648	nsubj	event,promotes
R9646	T14647	T14646	amod	pathophysiological,event
R9647	T14649	T14650	det	the,destabilization
R9648	T14650	T14648	dobj	destabilization,promotes
R9649	T14651	T14650	cc	and,destabilization
R9650	T14652	T14650	conj	degradation,destabilization
R9651	T14653	T14650	prep	of,destabilization
R9652	T14654	T14653	pobj	HKI,of
R9653	T14655	T14650	cc	and,destabilization
R9654	T14656	T14657	det	a,decrease
R9655	T14657	T14650	conj	decrease,destabilization
R9656	T14658	T14657	prep	in,decrease
R9657	T14659	T14660	compound	ATP,production
R9658	T14660	T14658	pobj	production,in
R9659	T14661	T14660	acl	required,production
R9660	T14662	T14663	aux	to,maintain
R9661	T14663	T14661	advcl	maintain,required
R9662	T14664	T14665	det	the,neurons
R9663	T14665	T14663	dobj	neurons,maintain
R9664	T14666	T14665	compound	depolarization,neurons
R9665	T14667	T14665	compound	state,neurons
R9666	T14668	T14657	punct	", ",decrease
R9667	T14669	T14657	cc	and,decrease
R9668	T14670	T14657	punct	", ",decrease
R9669	T14671	T14672	advmod	hence,reduction
R9670	T14672	T14657	conj	reduction,decrease
R9671	T14673	T14672	punct	", ",reduction
R9672	T14674	T14672	det	a,reduction
R9673	T14675	T14672	prep	in,reduction
R9674	T14676	T14677	det	the,response
R9675	T14677	T14675	pobj	response,in
R9676	T14678	T14677	prep	of,response
R9677	T14679	T14680	amod	receptoral,neurons
R9678	T14680	T14678	pobj	neurons,of
R9679	T14681	T14679	cc	and,receptoral
R9680	T14682	T14679	conj	postreceptoral,receptoral
R9681	T14683	T14648	punct	.,promotes
R9682	T14685	T14686	det	A,reduction
R9683	T14686	T14687	nsubj	reduction,modulates
R9684	T14688	T14686	prep	in,reduction
R9685	T14689	T14690	compound	ATP,levels
R9686	T14690	T14688	pobj	levels,in
R9687	T14691	T14687	advmod	also,modulates
R9688	T14692	T14687	advmod	negatively,modulates
R9689	T14693	T14694	compound	HKI,activity
R9690	T14694	T14687	dobj	activity,modulates
R9691	T14695	T14696	punct	/,level
R9692	T14696	T14694	prep	level,activity
R9693	T14697	T14687	punct	.,modulates
R9694	T14699	T14700	amod	Decreased,levels
R9695	T14700	T14701	nsubj	levels,promote
R9696	T14702	T14700	prep	of,levels
R9697	T14703	T14702	pobj	HKI,of
R9698	T14704	T14705	amod	intracellular,hyperglycemia
R9699	T14705	T14701	dobj	hyperglycemia,promote
R9700	T14706	T14701	cc	and,promote
R9701	T14707	T14701	conj	activate,promote
R9702	T14708	T14709	compound	stress,kinases
R9703	T14709	T14707	dobj	kinases,activate
R9704	T14710	T14709	punct	", ",kinases
R9705	T14711	T14712	dep	which,modulate
R9706	T14712	T14709	relcl	modulate,kinases
R9707	T14713	T14712	advmod	negatively,modulate
R9708	T14714	T14715	det	the,pump
R9709	T14715	T14712	dobj	pump,modulate
R9710	T14716	T14717	compound	Na+,K+
R9711	T14717	T14719	compound	K+,ATPase
R9712	T14718	T14717	punct	/,K+
R9713	T14719	T14715	compound	ATPase,pump
R9714	T14720	T14719	punct	-,ATPase
R9715	T14721	T14712	prep	by,modulate
R9716	T14722	T14721	pobj	phosphorylation,by
R9717	T14723	T14701	punct	.,promote
R9718	T14725	T14726	amod	Pathophysiological,pathways
R9719	T14726	T14727	nsubjpass	pathways,represented
R9720	T14728	T14726	acl	promoted,pathways
R9721	T14729	T14728	agent	by,promoted
R9722	T14730	T14731	compound	RanBP2,haploinsufficiency
R9723	T14731	T14729	pobj	haploinsufficiency,by
R9724	T14732	T14727	auxpass	are,represented
R9725	T14733	T14727	agent	by,represented
R9726	T14734	T14735	compound	dash,lines
R9727	T14735	T14733	pobj	lines,by
R9728	T14736	T14727	punct	.,represented
R9729	T14739	T14738	punct	", ",RIS
R9730	T14740	T14741	nmod	rod,segment
R9731	T14741	T14738	appos	segment,RIS
R9732	T14742	T14741	amod	inner,segment
R9733	T14743	T14738	punct	;,RIS
R9734	T14744	T14738	appos	ROS,RIS
R9735	T14745	T14744	punct	", ",ROS
R9736	T14746	T14747	nmod	rod,segment
R9737	T14747	T14744	appos	segment,ROS
R9738	T14748	T14747	amod	outer,segment
R9739	T14749	T14738	punct	.,RIS

PMC:1626108 / 31397-41172 JSONTXT 5 Projects

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PMC:1626108 / 31397-41172 JSON TXT 5 Projects