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PMC:1626108 / 27527-31395 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T5002 0-18 NN denotes Haploinsufficiency
T5004 19-21 IN denotes of
T5005 22-28 NN denotes RanBP2
T5003 29-35 VBZ denotes Causes
T5006 36-44 NNS denotes Deficits
T5007 45-47 IN denotes in
T5008 48-51 DT denotes the
T5010 52-72 JJ denotes Electrophysiological
T5009 73-79 NN denotes Output
T5011 80-82 IN denotes of
T5012 83-93 JJ denotes Receptoral
T5014 94-97 CC denotes and
T5015 98-112 JJ denotes Postreceptoral
T5016 113-120 JJ denotes Retinal
T5013 121-128 NNS denotes Neurons
T5017 128-661 sentence denotes In light of the prominent expression of RanBP2 and HKI in retinal neurons [1,19], the vital dependence of the neuronal retina (and brain) on glucose as the main substrate source for energy production, and the determinant impact of metabolic disorders, such as diabetes, in retinal function (e.g., diabetic retinopathy) [37], we probed the impact of deficits in RanBP2, HKI, and ATP, on the electrophysiological responses of subclasses (rod and cone) photoreceptor and postreceptor retinal neurons of RanBP2+/− and in RanBP2+/+ mice.
T5018 129-131 IN denotes In
T5020 132-137 NN denotes light
T5021 138-140 IN denotes of
T5022 141-144 DT denotes the
T5024 145-154 JJ denotes prominent
T5023 155-165 NN denotes expression
T5025 166-168 IN denotes of
T5026 169-175 NN denotes RanBP2
T5027 176-179 CC denotes and
T5028 180-183 NN denotes HKI
T5029 184-186 IN denotes in
T5030 187-194 JJ denotes retinal
T5031 195-202 NNS denotes neurons
T5032 203-204 -LRB- denotes [
T5034 204-205 CD denotes 1
T5035 205-206 , denotes ,
T5033 206-208 CD denotes 19
T5036 208-209 -RRB- denotes ]
T5037 209-211 , denotes ,
T5038 211-214 DT denotes the
T5040 215-220 JJ denotes vital
T5039 221-231 NN denotes dependence
T5041 232-234 IN denotes of
T5042 235-238 DT denotes the
T5044 239-247 JJ denotes neuronal
T5043 248-254 NN denotes retina
T5045 255-256 -LRB- denotes (
T5046 256-259 CC denotes and
T5047 260-265 NN denotes brain
T5048 265-266 -RRB- denotes )
T5049 267-269 IN denotes on
T5050 270-277 NN denotes glucose
T5051 278-280 IN denotes as
T5052 281-284 DT denotes the
T5054 285-289 JJ denotes main
T5055 290-299 NN denotes substrate
T5053 300-306 NN denotes source
T5056 307-310 IN denotes for
T5057 311-317 NN denotes energy
T5058 318-328 NN denotes production
T5059 328-330 , denotes ,
T5060 330-333 CC denotes and
T5061 334-337 DT denotes the
T5063 338-349 JJ denotes determinant
T5062 350-356 NN denotes impact
T5064 357-359 IN denotes of
T5065 360-369 JJ denotes metabolic
T5066 370-379 NNS denotes disorders
T5067 379-381 , denotes ,
T5068 381-385 IN denotes such
T5069 386-388 IN denotes as
T5070 389-397 NN denotes diabetes
T5071 397-399 , denotes ,
T5072 399-401 IN denotes in
T5073 402-409 JJ denotes retinal
T5074 410-418 NN denotes function
T5075 419-420 -LRB- denotes (
T5076 420-424 FW denotes e.g.
T5078 424-426 , denotes ,
T5079 426-434 JJ denotes diabetic
T5077 435-446 NN denotes retinopathy
T5080 446-447 -RRB- denotes )
T5081 448-449 -LRB- denotes [
T5082 449-451 CD denotes 37
T5083 451-452 -RRB- denotes ]
T5084 452-454 , denotes ,
T5085 454-456 PRP denotes we
T5019 457-463 VBD denotes probed
T5086 464-467 DT denotes the
T5087 468-474 NN denotes impact
T5088 475-477 IN denotes of
T5089 478-486 NNS denotes deficits
T5090 487-489 IN denotes in
T5091 490-496 NN denotes RanBP2
T5092 496-498 , denotes ,
T5093 498-501 NN denotes HKI
T5094 501-503 , denotes ,
T5095 503-506 CC denotes and
T5096 507-510 NN denotes ATP
T5097 510-512 , denotes ,
T5098 512-514 IN denotes on
T5099 515-518 DT denotes the
T5101 519-539 JJ denotes electrophysiological
T5100 540-549 NNS denotes responses
T5102 550-552 IN denotes of
T5103 553-563 NNS denotes subclasses
T5105 564-565 -LRB- denotes (
T5106 565-568 NN denotes rod
T5107 569-572 CC denotes and
T5108 573-577 NN denotes cone
T5109 577-578 -RRB- denotes )
T5110 579-592 NN denotes photoreceptor
T5111 593-596 CC denotes and
T5112 597-609 NN denotes postreceptor
T5113 610-617 JJ denotes retinal
T5104 618-625 NNS denotes neurons
T5114 626-628 IN denotes of
T5115 629-635 NN denotes RanBP2
T5116 635-636 SYM denotes +
T5117 636-637 HYPH denotes /
T5118 637-638 SYM denotes −
T5119 639-642 CC denotes and
T5120 643-645 IN denotes in
T5121 646-652 NN denotes RanBP2
T5123 652-653 SYM denotes +
T5124 653-654 HYPH denotes /
T5125 654-655 SYM denotes +
T5122 656-660 NNS denotes mice
T5126 660-661 . denotes .
T5127 661-888 sentence denotes The scotopic (dark-adapted) responses mediated by the rod photoreceptor pathway at low-stimulus intensities and mixed rod and cone pathways at high-stimulus intensities were substantially reduced in RanBP2+/− mice (Figure 8A).
T5128 662-665 DT denotes The
T5130 666-674 JJ denotes scotopic
T5131 675-676 -LRB- denotes (
T5133 676-680 NN denotes dark
T5134 680-681 HYPH denotes -
T5132 681-688 VBN denotes adapted
T5135 688-689 -RRB- denotes )
T5129 690-699 NNS denotes responses
T5137 700-708 VBN denotes mediated
T5138 709-711 IN denotes by
T5139 712-715 DT denotes the
T5141 716-719 NN denotes rod
T5142 720-733 NN denotes photoreceptor
T5140 734-741 NN denotes pathway
T5143 742-744 IN denotes at
T5144 745-748 JJ denotes low
T5146 748-749 HYPH denotes -
T5145 749-757 NN denotes stimulus
T5147 758-769 NNS denotes intensities
T5148 770-773 CC denotes and
T5149 774-779 JJ denotes mixed
T5151 780-783 NN denotes rod
T5152 784-787 CC denotes and
T5153 788-792 NN denotes cone
T5150 793-801 NNS denotes pathways
T5154 802-804 IN denotes at
T5155 805-809 JJ denotes high
T5157 809-810 HYPH denotes -
T5156 810-818 NN denotes stimulus
T5158 819-830 NNS denotes intensities
T5159 831-835 VBD denotes were
T5160 836-849 RB denotes substantially
T5136 850-857 VBN denotes reduced
T5161 858-860 IN denotes in
T5162 861-867 NN denotes RanBP2
T5164 867-868 SYM denotes +
T5165 868-869 HYPH denotes /
T5166 869-870 SYM denotes −
T5163 871-875 NNS denotes mice
T5167 876-877 -LRB- denotes (
T5169 877-883 NN denotes Figure
T5168 884-886 NN denotes 8A
T5170 886-887 -RRB- denotes )
T5171 887-888 . denotes .
T5172 888-1193 sentence denotes The differences in the photopic (light-adapted) responses, initiated by cone photoreceptors, which make up 3% of the photosensory neurons in the mouse retina [38], were less obvious but still exhibited a trend toward reduced amplitudes across a range of increasing light stimulus intensities (Figure 8B).
T5173 889-892 DT denotes The
T5174 893-904 NNS denotes differences
T5176 905-907 IN denotes in
T5177 908-911 DT denotes the
T5179 912-920 JJ denotes photopic
T5180 921-922 -LRB- denotes (
T5182 922-927 NN denotes light
T5183 927-928 HYPH denotes -
T5181 928-935 VBN denotes adapted
T5184 935-936 -RRB- denotes )
T5178 937-946 NNS denotes responses
T5185 946-948 , denotes ,
T5186 948-957 VBN denotes initiated
T5187 958-960 IN denotes by
T5188 961-965 NN denotes cone
T5189 966-980 NNS denotes photoreceptors
T5190 980-982 , denotes ,
T5191 982-987 WDT denotes which
T5192 988-992 VBP denotes make
T5193 993-995 RP denotes up
T5194 996-997 CD denotes 3
T5195 997-998 NN denotes %
T5196 999-1001 IN denotes of
T5197 1002-1005 DT denotes the
T5199 1006-1018 JJ denotes photosensory
T5198 1019-1026 NNS denotes neurons
T5200 1027-1029 IN denotes in
T5201 1030-1033 DT denotes the
T5203 1034-1039 NN denotes mouse
T5202 1040-1046 NN denotes retina
T5204 1047-1048 -LRB- denotes [
T5205 1048-1050 CD denotes 38
T5206 1050-1051 -RRB- denotes ]
T5207 1051-1053 , denotes ,
T5175 1053-1057 VBD denotes were
T5208 1058-1062 RBR denotes less
T5209 1063-1070 JJ denotes obvious
T5210 1071-1074 CC denotes but
T5211 1075-1080 RB denotes still
T5212 1081-1090 VBD denotes exhibited
T5213 1091-1092 DT denotes a
T5214 1093-1098 NN denotes trend
T5215 1099-1105 IN denotes toward
T5216 1106-1113 VBN denotes reduced
T5217 1114-1124 NNS denotes amplitudes
T5218 1125-1131 IN denotes across
T5219 1132-1133 DT denotes a
T5220 1134-1139 NN denotes range
T5221 1140-1142 IN denotes of
T5222 1143-1153 VBG denotes increasing
T5224 1154-1159 JJ denotes light
T5225 1160-1168 NN denotes stimulus
T5223 1169-1180 NNS denotes intensities
T5226 1181-1182 -LRB- denotes (
T5228 1182-1188 NN denotes Figure
T5227 1189-1191 NN denotes 8B
T5229 1191-1192 -RRB- denotes )
T5230 1192-1193 . denotes .
T5231 1193-1378 sentence denotes The reduction in the scotopic responses included decreases in both b-wave (Figure 8C) and a-wave (Figure 8D) amplitudes mediated by postreceptoral and receptoral neurons, respectively.
T5232 1194-1197 DT denotes The
T5233 1198-1207 NN denotes reduction
T5235 1208-1210 IN denotes in
T5236 1211-1214 DT denotes the
T5238 1215-1223 JJ denotes scotopic
T5237 1224-1233 NNS denotes responses
T5234 1234-1242 VBD denotes included
T5239 1243-1252 NNS denotes decreases
T5240 1253-1255 IN denotes in
T5241 1256-1260 CC denotes both
T5243 1261-1262 NN denotes b
T5244 1262-1263 HYPH denotes -
T5242 1263-1267 NN denotes wave
T5246 1268-1269 -LRB- denotes (
T5248 1269-1275 NN denotes Figure
T5247 1276-1278 NN denotes 8C
T5249 1278-1279 -RRB- denotes )
T5250 1280-1283 CC denotes and
T5251 1284-1285 NN denotes a
T5253 1285-1286 HYPH denotes -
T5252 1286-1290 NN denotes wave
T5254 1291-1292 -LRB- denotes (
T5256 1292-1298 NN denotes Figure
T5255 1299-1301 NN denotes 8D
T5257 1301-1302 -RRB- denotes )
T5245 1303-1313 NNS denotes amplitudes
T5258 1314-1322 VBN denotes mediated
T5259 1323-1325 IN denotes by
T5260 1326-1340 JJ denotes postreceptoral
T5262 1341-1344 CC denotes and
T5263 1345-1355 JJ denotes receptoral
T5261 1356-1363 NNS denotes neurons
T5264 1363-1365 , denotes ,
T5265 1365-1377 RB denotes respectively
T5266 1377-1378 . denotes .
T5267 1378-1573 sentence denotes Postreceptoral second-order neuron responses, represented by the b-wave, tended to be more consistently and substantially reduced than the a-waves, which directly reflect photoreceptor activity.
T5268 1379-1393 JJ denotes Postreceptoral
T5270 1394-1400 JJ denotes second
T5272 1400-1401 HYPH denotes -
T5271 1401-1406 NN denotes order
T5273 1407-1413 NN denotes neuron
T5269 1414-1423 NNS denotes responses
T5275 1423-1425 , denotes ,
T5276 1425-1436 VBN denotes represented
T5277 1437-1439 IN denotes by
T5278 1440-1443 DT denotes the
T5280 1444-1445 NN denotes b
T5281 1445-1446 HYPH denotes -
T5279 1446-1450 NN denotes wave
T5282 1450-1452 , denotes ,
T5274 1452-1458 VBD denotes tended
T5283 1459-1461 TO denotes to
T5284 1462-1464 VB denotes be
T5285 1465-1469 RBR denotes more
T5287 1470-1482 RB denotes consistently
T5288 1483-1486 CC denotes and
T5289 1487-1500 RB denotes substantially
T5286 1501-1508 VBN denotes reduced
T5290 1509-1513 IN denotes than
T5291 1514-1517 DT denotes the
T5293 1518-1519 NN denotes a
T5294 1519-1520 HYPH denotes -
T5292 1520-1525 NNS denotes waves
T5295 1525-1527 , denotes ,
T5296 1527-1532 WDT denotes which
T5298 1533-1541 RB denotes directly
T5297 1542-1549 VBP denotes reflect
T5299 1550-1563 NN denotes photoreceptor
T5300 1564-1572 NN denotes activity
T5301 1572-1573 . denotes .
T5302 1573-1812 sentence denotes Since second-order neuron responses depend on input from photoreceptors, this suggests that reduced b-wave amplitudes are the result of the accumulation of decreases in the light response of both photoreceptors and postreceptoral neurons.
T5303 1574-1579 IN denotes Since
T5305 1580-1586 JJ denotes second
T5307 1586-1587 HYPH denotes -
T5306 1587-1592 NN denotes order
T5309 1593-1599 NN denotes neuron
T5308 1600-1609 NNS denotes responses
T5304 1610-1616 VBP denotes depend
T5311 1617-1619 IN denotes on
T5312 1620-1625 NN denotes input
T5313 1626-1630 IN denotes from
T5314 1631-1645 NNS denotes photoreceptors
T5315 1645-1647 , denotes ,
T5316 1647-1651 DT denotes this
T5310 1652-1660 VBZ denotes suggests
T5317 1661-1665 IN denotes that
T5319 1666-1673 VBN denotes reduced
T5321 1674-1675 NN denotes b
T5323 1675-1676 HYPH denotes -
T5322 1676-1680 NN denotes wave
T5320 1681-1691 NNS denotes amplitudes
T5318 1692-1695 VBP denotes are
T5324 1696-1699 DT denotes the
T5325 1700-1706 NN denotes result
T5326 1707-1709 IN denotes of
T5327 1710-1713 DT denotes the
T5328 1714-1726 NN denotes accumulation
T5329 1727-1729 IN denotes of
T5330 1730-1739 NNS denotes decreases
T5331 1740-1742 IN denotes in
T5332 1743-1746 DT denotes the
T5334 1747-1752 JJ denotes light
T5333 1753-1761 NN denotes response
T5335 1762-1764 IN denotes of
T5336 1765-1769 CC denotes both
T5337 1770-1784 NNS denotes photoreceptors
T5338 1785-1788 CC denotes and
T5339 1789-1803 JJ denotes postreceptoral
T5340 1804-1811 NNS denotes neurons
T5341 1811-1812 . denotes .
T5342 1812-1954 sentence denotes Anesthetics, particularly ketamine, can cause sustained elevation of glucose in mice, which in turn affects electroretinogram responses [39].
T5343 1813-1824 NNS denotes Anesthetics
T5345 1824-1826 , denotes ,
T5346 1826-1838 RB denotes particularly
T5347 1839-1847 NN denotes ketamine
T5348 1847-1849 , denotes ,
T5349 1849-1852 MD denotes can
T5344 1853-1858 VB denotes cause
T5350 1859-1868 JJ denotes sustained
T5351 1869-1878 NN denotes elevation
T5352 1879-1881 IN denotes of
T5353 1882-1889 NN denotes glucose
T5354 1890-1892 IN denotes in
T5355 1893-1897 NNS denotes mice
T5356 1897-1899 , denotes ,
T5357 1899-1904 WDT denotes which
T5359 1905-1907 IN denotes in
T5360 1908-1912 NN denotes turn
T5358 1913-1920 VBZ denotes affects
T5361 1921-1938 NN denotes electroretinogram
T5362 1939-1948 NNS denotes responses
T5363 1949-1950 -LRB- denotes [
T5364 1950-1952 CD denotes 39
T5365 1952-1953 -RRB- denotes ]
T5366 1953-1954 . denotes .
T5367 1954-2135 sentence denotes Thus, we were concerned that differences in electroretinogram amplitudes between RanBP2+/− and RanBP2+/+ may reflect differences in glucose level changes in response to anesthesia.
T5368 1955-1959 RB denotes Thus
T5370 1959-1961 , denotes ,
T5371 1961-1963 PRP denotes we
T5369 1964-1968 VBD denotes were
T5372 1969-1978 JJ denotes concerned
T5373 1979-1983 IN denotes that
T5375 1984-1995 NNS denotes differences
T5376 1996-1998 IN denotes in
T5377 1999-2016 NN denotes electroretinogram
T5378 2017-2027 NNS denotes amplitudes
T5379 2028-2035 IN denotes between
T5380 2036-2042 NN denotes RanBP2
T5381 2042-2043 SYM denotes +
T5382 2043-2044 HYPH denotes /
T5383 2044-2045 SYM denotes −
T5384 2046-2049 CC denotes and
T5385 2050-2056 NN denotes RanBP2
T5386 2056-2057 SYM denotes +
T5387 2057-2058 HYPH denotes /
T5388 2058-2059 SYM denotes +
T5389 2060-2063 MD denotes may
T5374 2064-2071 VB denotes reflect
T5390 2072-2083 NNS denotes differences
T5391 2084-2086 IN denotes in
T5392 2087-2094 NN denotes glucose
T5393 2095-2100 NN denotes level
T5394 2101-2108 NNS denotes changes
T5395 2109-2111 IN denotes in
T5396 2112-2120 NN denotes response
T5397 2121-2123 IN denotes to
T5398 2124-2134 NN denotes anesthesia
T5399 2134-2135 . denotes .
T5400 2135-2270 sentence denotes However, we found no significant differences in glucose levels measured before and every 15 min during 75 min of anesthesia (n = 4–5).
T5401 2136-2143 RB denotes However
T5403 2143-2145 , denotes ,
T5404 2145-2147 PRP denotes we
T5402 2148-2153 VBD denotes found
T5405 2154-2156 DT denotes no
T5407 2157-2168 JJ denotes significant
T5406 2169-2180 NNS denotes differences
T5408 2181-2183 IN denotes in
T5409 2184-2191 NN denotes glucose
T5410 2192-2198 NNS denotes levels
T5411 2199-2207 VBN denotes measured
T5412 2208-2214 IN denotes before
T5413 2215-2218 CC denotes and
T5414 2219-2224 DT denotes every
T5416 2225-2227 CD denotes 15
T5415 2228-2231 NNS denotes min
T5417 2232-2238 IN denotes during
T5419 2239-2241 CD denotes 75
T5418 2242-2245 NNS denotes min
T5420 2246-2248 IN denotes of
T5421 2249-2259 NN denotes anesthesia
T5422 2260-2261 -LRB- denotes (
T5424 2261-2262 NN denotes n
T5425 2263-2264 SYM denotes =
T5426 2265-2266 CD denotes 4
T5427 2266-2267 SYM denotes –
T5423 2267-2268 CD denotes 5
T5428 2268-2269 -RRB- denotes )
T5429 2269-2270 . denotes .
T5430 2270-2412 sentence denotes Glucose rose at the same rate and reached a maximum of approximately 3.3 times the pre-anesthesia level in both genotypes (unpublished data).
T5431 2271-2278 NN denotes Glucose
T5432 2279-2283 VBD denotes rose
T5433 2284-2286 IN denotes at
T5434 2287-2290 DT denotes the
T5436 2291-2295 JJ denotes same
T5435 2296-2300 NN denotes rate
T5437 2301-2304 CC denotes and
T5438 2305-2312 VBD denotes reached
T5439 2313-2314 DT denotes a
T5440 2315-2322 NN denotes maximum
T5441 2323-2325 IN denotes of
T5442 2326-2339 RB denotes approximately
T5443 2340-2343 CD denotes 3.3
T5445 2344-2349 NNS denotes times
T5446 2350-2353 DT denotes the
T5447 2354-2368 JJ denotes pre-anesthesia
T5444 2369-2374 NN denotes level
T5448 2375-2377 IN denotes in
T5449 2378-2382 DT denotes both
T5450 2383-2392 NNS denotes genotypes
T5451 2393-2394 -LRB- denotes (
T5453 2394-2405 JJ denotes unpublished
T5452 2406-2410 NNS denotes data
T5454 2410-2411 -RRB- denotes )
T5455 2411-2412 . denotes .
T14065 2423-2441 NNS denotes Electroretinograms
T14066 2442-2446 IN denotes from
T14067 2447-2448 CD denotes 6
T14069 2448-2449 HYPH denotes -
T14068 2449-2451 NN denotes Mo
T14071 2451-2452 HYPH denotes -
T14070 2452-2455 JJ denotes Old
T14073 2456-2462 NN denotes RanBP2
T14074 2462-2463 SYM denotes +
T14075 2463-2464 HYPH denotes /
T14076 2464-2465 SYM denotes −
T14077 2465-2468 CC denotes and
T14078 2469-2475 NN denotes RanBP2
T14079 2475-2476 SYM denotes +
T14080 2476-2477 HYPH denotes /
T14081 2477-2478 SYM denotes +
T14082 2479-2485 JJ denotes Inbred
T14072 2486-2490 NNS denotes Mice
T14083 2491-2498 VBG denotes Showing
T14084 2499-2512 NN denotes Photoreceptor
T14086 2513-2516 CC denotes and
T14087 2517-2529 NN denotes Postreceptor
T14085 2530-2536 NN denotes Neuron
T14089 2537-2557 JJ denotes Electrophysiological
T14090 2558-2566 NN denotes Response
T14088 2567-2577 NNS denotes Phenotypes
T14091 2577-2771 sentence denotes (A) Scotopic (dark-adapted) responses from RanBP2+/− mice to light stimuli of increasing intensity, beginning at threshold, have reduced amplitudes compared to those observed in RanBP2+/+ mice.
T14092 2578-2579 -LRB- denotes (
T14093 2579-2580 LS denotes A
T14095 2580-2581 -RRB- denotes )
T14096 2582-2590 JJ denotes Scotopic
T14098 2591-2592 -LRB- denotes (
T14100 2592-2596 NN denotes dark
T14101 2596-2597 HYPH denotes -
T14099 2597-2604 VBN denotes adapted
T14102 2604-2605 -RRB- denotes )
T14097 2606-2615 NNS denotes responses
T14103 2616-2620 IN denotes from
T14104 2621-2627 NN denotes RanBP2
T14106 2627-2628 SYM denotes +
T14107 2628-2629 HYPH denotes /
T14108 2629-2630 SYM denotes −
T14105 2631-2635 NNS denotes mice
T14109 2636-2638 IN denotes to
T14110 2639-2644 JJ denotes light
T14111 2645-2652 NNS denotes stimuli
T14112 2653-2655 IN denotes of
T14113 2656-2666 VBG denotes increasing
T14114 2667-2676 NN denotes intensity
T14115 2676-2678 , denotes ,
T14116 2678-2687 VBG denotes beginning
T14117 2688-2690 IN denotes at
T14118 2691-2700 NN denotes threshold
T14119 2700-2702 , denotes ,
T14094 2702-2706 VBP denotes have
T14120 2707-2714 JJ denotes reduced
T14121 2715-2725 NNS denotes amplitudes
T14122 2726-2734 VBN denotes compared
T14123 2735-2737 IN denotes to
T14124 2738-2743 DT denotes those
T14125 2744-2752 VBN denotes observed
T14126 2753-2755 IN denotes in
T14127 2756-2762 NN denotes RanBP2
T14129 2762-2763 SYM denotes +
T14130 2763-2764 HYPH denotes /
T14131 2764-2765 SYM denotes +
T14128 2766-2770 NNS denotes mice
T14132 2770-2771 . denotes .
T14133 2771-2872 sentence denotes The three lower intensities represent responses generated in the rod photoreceptor neuronal pathway.
T14134 2772-2775 DT denotes The
T14136 2776-2781 CD denotes three
T14137 2782-2787 JJR denotes lower
T14135 2788-2799 NNS denotes intensities
T14138 2800-2809 VBP denotes represent
T14139 2810-2819 NNS denotes responses
T14140 2820-2829 VBN denotes generated
T14141 2830-2832 IN denotes in
T14142 2833-2836 DT denotes the
T14144 2837-2840 NN denotes rod
T14145 2841-2854 NN denotes photoreceptor
T14146 2855-2863 JJ denotes neuronal
T14143 2864-2871 NN denotes pathway
T14147 2871-2872 . denotes .
T14148 2872-2966 sentence denotes The upper intensities are comprised of responses generated in both the rod and cone pathways.
T14149 2873-2876 DT denotes The
T14151 2877-2882 JJ denotes upper
T14150 2883-2894 NNS denotes intensities
T14153 2895-2898 VBP denotes are
T14152 2899-2908 VBN denotes comprised
T14154 2909-2911 IN denotes of
T14155 2912-2921 NNS denotes responses
T14156 2922-2931 VBN denotes generated
T14157 2932-2934 IN denotes in
T14158 2935-2939 CC denotes both
T14160 2940-2943 DT denotes the
T14161 2944-2947 NN denotes rod
T14162 2948-2951 CC denotes and
T14163 2952-2956 NN denotes cone
T14159 2957-2965 NNS denotes pathways
T14164 2965-2966 . denotes .
T14165 2966-3172 sentence denotes (B) Photopic (light-adapted, cone photoreceptor pathway) responses of RanBP2+/− mice to increasing light stimulus intensities also exhibited reduced amplitudes compared to those observed in RanBP2+/+ mice.
T14166 2967-2968 -LRB- denotes (
T14167 2968-2969 LS denotes B
T14169 2969-2970 -RRB- denotes )
T14170 2971-2979 JJ denotes Photopic
T14172 2980-2981 -LRB- denotes (
T14174 2981-2986 NN denotes light
T14176 2986-2987 HYPH denotes -
T14175 2987-2994 VBN denotes adapted
T14177 2994-2996 , denotes ,
T14178 2996-3000 NN denotes cone
T14179 3001-3014 NN denotes photoreceptor
T14173 3015-3022 NN denotes pathway
T14180 3022-3023 -RRB- denotes )
T14171 3024-3033 NNS denotes responses
T14181 3034-3036 IN denotes of
T14182 3037-3043 NN denotes RanBP2
T14184 3043-3044 SYM denotes +
T14185 3044-3045 HYPH denotes /
T14186 3045-3046 SYM denotes −
T14183 3047-3051 NNS denotes mice
T14187 3052-3054 IN denotes to
T14188 3055-3065 VBG denotes increasing
T14190 3066-3071 JJ denotes light
T14191 3072-3080 NN denotes stimulus
T14189 3081-3092 NNS denotes intensities
T14192 3093-3097 RB denotes also
T14168 3098-3107 VBD denotes exhibited
T14193 3108-3115 VBN denotes reduced
T14194 3116-3126 NNS denotes amplitudes
T14195 3127-3135 VBN denotes compared
T14196 3136-3138 IN denotes to
T14197 3139-3144 DT denotes those
T14198 3145-3153 VBN denotes observed
T14199 3154-3156 IN denotes in
T14200 3157-3163 NN denotes RanBP2
T14202 3163-3164 SYM denotes +
T14203 3164-3165 HYPH denotes /
T14204 3165-3166 SYM denotes +
T14201 3167-3171 NNS denotes mice
T14205 3171-3172 . denotes .
T14206 3172-3335 sentence denotes (C) Average ± SE (n = 9) scotopic b-wave amplitudes from RanBP2+/− (open circles) and RanBP2+/+ (filled squares) mice representing postreceptoral neuron function.
T14207 3173-3174 -LRB- denotes (
T14208 3174-3175 LS denotes C
T14210 3175-3176 -RRB- denotes )
T14211 3177-3184 NN denotes Average
T14213 3185-3186 SYM denotes ±
T14212 3187-3189 NN denotes SE
T14214 3190-3191 -LRB- denotes (
T14216 3191-3192 NN denotes n
T14217 3193-3194 SYM denotes =
T14215 3195-3196 CD denotes 9
T14218 3196-3197 -RRB- denotes )
T14219 3198-3206 JJ denotes scotopic
T14220 3207-3208 NN denotes b
T14222 3208-3209 HYPH denotes -
T14221 3209-3213 NN denotes wave
T14209 3214-3224 NNS denotes amplitudes
T14223 3225-3229 IN denotes from
T14224 3230-3236 NN denotes RanBP2
T14226 3236-3237 SYM denotes +
T14227 3237-3238 HYPH denotes /
T14228 3238-3239 SYM denotes −
T14229 3240-3241 -LRB- denotes (
T14231 3241-3245 JJ denotes open
T14230 3246-3253 NNS denotes circles
T14232 3253-3254 -RRB- denotes )
T14233 3255-3258 CC denotes and
T14234 3259-3265 NN denotes RanBP2
T14235 3265-3266 SYM denotes +
T14236 3266-3267 HYPH denotes /
T14237 3267-3268 SYM denotes +
T14238 3269-3270 -LRB- denotes (
T14240 3270-3276 VBN denotes filled
T14239 3277-3284 NNS denotes squares
T14241 3284-3285 -RRB- denotes )
T14225 3286-3290 NNS denotes mice
T14242 3291-3303 VBG denotes representing
T14243 3304-3318 JJ denotes postreceptoral
T14244 3319-3325 NN denotes neuron
T14245 3326-3334 NN denotes function
T14246 3334-3335 . denotes .
T14247 3335-3364 sentence denotes (Note: log amplitude scale.)
T14248 3336-3337 -LRB- denotes (
T14250 3337-3341 NN denotes Note
T14251 3341-3343 : denotes :
T14252 3343-3346 NN denotes log
T14253 3347-3356 NN denotes amplitude
T14249 3357-3362 NN denotes scale
T14254 3362-3363 . denotes .
T14255 3363-3364 -RRB- denotes )
T14256 3364-3518 sentence denotes (D) Average ± SE (n = 5) scotopic a-wave amplitudes, representing photoreceptor function, for RanBP2+/− and RanBP2+/+ mice in response to bright flashes.
T14257 3365-3366 -LRB- denotes (
T14258 3366-3367 LS denotes D
T14260 3367-3368 -RRB- denotes )
T14261 3369-3376 JJ denotes Average
T14263 3377-3378 SYM denotes ±
T14262 3379-3381 NN denotes SE
T14264 3382-3383 -LRB- denotes (
T14266 3383-3384 NN denotes n
T14267 3385-3386 SYM denotes =
T14265 3387-3388 CD denotes 5
T14268 3388-3389 -RRB- denotes )
T14269 3390-3398 JJ denotes scotopic
T14270 3399-3400 NN denotes a
T14272 3400-3401 HYPH denotes -
T14271 3401-3405 NN denotes wave
T14259 3406-3416 NNS denotes amplitudes
T14273 3416-3418 , denotes ,
T14274 3418-3430 VBG denotes representing
T14275 3431-3444 NN denotes photoreceptor
T14276 3445-3453 NN denotes function
T14277 3453-3455 , denotes ,
T14278 3455-3458 IN denotes for
T14279 3459-3465 NN denotes RanBP2
T14281 3465-3466 SYM denotes +
T14282 3466-3467 HYPH denotes /
T14283 3467-3468 SYM denotes −
T14284 3469-3472 CC denotes and
T14285 3473-3479 NN denotes RanBP2
T14286 3479-3480 SYM denotes +
T14287 3480-3481 HYPH denotes /
T14288 3481-3482 SYM denotes +
T14280 3483-3487 NNS denotes mice
T14289 3488-3490 IN denotes in
T14290 3491-3499 NN denotes response
T14291 3500-3502 IN denotes to
T14292 3503-3509 JJ denotes bright
T14293 3510-3517 NNS denotes flashes
T14294 3517-3518 . denotes .
T14295 3518-3644 sentence denotes Amplitudes of responses from RanBP2+/− mice were lower over the entire range of stimulus intensities for both b- and a-waves.
T14296 3519-3529 NNS denotes Amplitudes
T14298 3530-3532 IN denotes of
T14299 3533-3542 NNS denotes responses
T14300 3543-3547 IN denotes from
T14301 3548-3554 NN denotes RanBP2
T14303 3554-3555 SYM denotes +
T14304 3555-3556 HYPH denotes /
T14305 3556-3557 SYM denotes −
T14302 3558-3562 NNS denotes mice
T14297 3563-3567 VBD denotes were
T14306 3568-3573 JJR denotes lower
T14307 3574-3578 IN denotes over
T14308 3579-3582 DT denotes the
T14310 3583-3589 JJ denotes entire
T14309 3590-3595 NN denotes range
T14311 3596-3598 IN denotes of
T14312 3599-3607 NN denotes stimulus
T14313 3608-3619 NNS denotes intensities
T14314 3620-3623 IN denotes for
T14315 3624-3628 CC denotes both
T14316 3629-3630 NN denotes b
T14318 3630-3631 HYPH denotes -
T14319 3632-3635 CC denotes and
T14320 3636-3637 NN denotes a
T14321 3637-3638 HYPH denotes -
T14317 3638-3643 NNS denotes waves
T14322 3643-3644 . denotes .
T14323 3644-3737 sentence denotes Asterisks represent significant differences between the groups (Student's t test, p < 0.05).
T14324 3645-3654 NNS denotes Asterisks
T14325 3655-3664 VBP denotes represent
T14326 3665-3676 JJ denotes significant
T14327 3677-3688 NNS denotes differences
T14328 3689-3696 IN denotes between
T14329 3697-3700 DT denotes the
T14330 3701-3707 NNS denotes groups
T14331 3708-3709 -LRB- denotes (
T14333 3709-3716 NN denotes Student
T14334 3716-3718 POS denotes 's
T14335 3719-3720 NN denotes t
T14332 3721-3725 NN denotes test
T14336 3725-3727 , denotes ,
T14337 3727-3728 NN denotes p
T14339 3729-3730 SYM denotes <
T14338 3731-3735 CD denotes 0.05
T14340 3735-3736 -RRB- denotes )
T14341 3736-3737 . denotes .
T14342 3737-3868 sentence denotes Statistical significance was found across all intensities for b-wave amplitudes (2-way ANOVA, p < 0.0001), but not for the a-wave.
T14343 3738-3749 JJ denotes Statistical
T14344 3750-3762 NN denotes significance
T14346 3763-3766 VBD denotes was
T14345 3767-3772 VBN denotes found
T14347 3773-3779 IN denotes across
T14348 3780-3783 DT denotes all
T14349 3784-3795 NNS denotes intensities
T14350 3796-3799 IN denotes for
T14351 3800-3801 NN denotes b
T14353 3801-3802 HYPH denotes -
T14352 3802-3806 NN denotes wave
T14354 3807-3817 NNS denotes amplitudes
T14355 3818-3819 -LRB- denotes (
T14357 3819-3820 CD denotes 2
T14359 3820-3821 HYPH denotes -
T14358 3821-3824 NN denotes way
T14356 3825-3830 NNP denotes ANOVA
T14360 3830-3832 , denotes ,
T14361 3832-3833 NN denotes p
T14363 3834-3835 SYM denotes <
T14362 3836-3842 CD denotes 0.0001
T14364 3842-3843 -RRB- denotes )
T14365 3843-3845 , denotes ,
T14366 3845-3848 CC denotes but
T14367 3849-3852 RB denotes not
T14368 3853-3856 IN denotes for
T14369 3857-3860 DT denotes the
T14371 3861-3862 NN denotes a
T14372 3862-3863 HYPH denotes -
T14370 3863-3867 NN denotes wave
T14373 3867-3868 . denotes .
R3106 T5002 T5003 nsubj Haploinsufficiency,Causes
R3107 T5004 T5002 prep of,Haploinsufficiency
R3108 T5005 T5004 pobj RanBP2,of
R3109 T5006 T5003 dobj Deficits,Causes
R3110 T5007 T5003 prep in,Causes
R3111 T5008 T5009 det the,Output
R3112 T5009 T5007 pobj Output,in
R3113 T5010 T5009 amod Electrophysiological,Output
R3114 T5011 T5009 prep of,Output
R3115 T5012 T5013 amod Receptoral,Neurons
R3116 T5013 T5011 pobj Neurons,of
R3117 T5014 T5012 cc and,Receptoral
R3118 T5015 T5012 conj Postreceptoral,Receptoral
R3119 T5016 T5013 amod Retinal,Neurons
R3120 T5018 T5019 prep In,probed
R3121 T5020 T5018 pobj light,In
R3122 T5021 T5020 prep of,light
R3123 T5022 T5023 det the,expression
R3124 T5023 T5021 pobj expression,of
R3125 T5024 T5023 amod prominent,expression
R3126 T5025 T5023 prep of,expression
R3127 T5026 T5025 pobj RanBP2,of
R3128 T5027 T5026 cc and,RanBP2
R3129 T5028 T5026 conj HKI,RanBP2
R3130 T5029 T5023 prep in,expression
R3131 T5030 T5031 amod retinal,neurons
R3132 T5031 T5029 pobj neurons,in
R3133 T5032 T5033 punct [,19
R3134 T5033 T5023 parataxis 19,expression
R3135 T5034 T5033 nummod 1,19
R3136 T5035 T5033 punct ",",19
R3137 T5036 T5033 punct ],19
R3138 T5037 T5023 punct ", ",expression
R3139 T5038 T5039 det the,dependence
R3140 T5039 T5023 conj dependence,expression
R3141 T5040 T5039 amod vital,dependence
R3142 T5041 T5039 prep of,dependence
R3143 T5042 T5043 det the,retina
R3144 T5043 T5041 pobj retina,of
R3145 T5044 T5043 amod neuronal,retina
R3146 T5045 T5043 punct (,retina
R3147 T5046 T5043 cc and,retina
R3148 T5047 T5043 conj brain,retina
R3149 T5048 T5039 punct ),dependence
R3150 T5049 T5039 prep on,dependence
R3151 T5050 T5049 pobj glucose,on
R3152 T5051 T5039 prep as,dependence
R3153 T5052 T5053 det the,source
R3154 T5053 T5051 pobj source,as
R3155 T5054 T5053 amod main,source
R3156 T5055 T5053 compound substrate,source
R3157 T5056 T5053 prep for,source
R3158 T5057 T5058 compound energy,production
R3159 T5058 T5056 pobj production,for
R3160 T5059 T5039 punct ", ",dependence
R3161 T5060 T5039 cc and,dependence
R3162 T5061 T5062 det the,impact
R3163 T5062 T5039 conj impact,dependence
R3164 T5063 T5062 amod determinant,impact
R3165 T5064 T5062 prep of,impact
R3166 T5065 T5066 amod metabolic,disorders
R3167 T5066 T5064 pobj disorders,of
R3168 T5067 T5066 punct ", ",disorders
R3169 T5068 T5066 prep such,disorders
R3170 T5069 T5068 pcomp as,such
R3171 T5070 T5068 pobj diabetes,such
R3172 T5071 T5062 punct ", ",impact
R3173 T5072 T5062 prep in,impact
R3174 T5073 T5074 amod retinal,function
R3175 T5074 T5072 pobj function,in
R3176 T5075 T5062 punct (,impact
R3177 T5076 T5077 advmod e.g.,retinopathy
R3178 T5077 T5062 appos retinopathy,impact
R3179 T5078 T5077 punct ", ",retinopathy
R3180 T5079 T5077 amod diabetic,retinopathy
R3181 T5080 T5062 punct ),impact
R3182 T5081 T5082 punct [,37
R3183 T5082 T5062 parataxis 37,impact
R3184 T5083 T5082 punct ],37
R3185 T5084 T5019 punct ", ",probed
R3186 T5085 T5019 nsubj we,probed
R3187 T5086 T5087 det the,impact
R3188 T5087 T5019 dobj impact,probed
R3189 T5088 T5087 prep of,impact
R3190 T5089 T5088 pobj deficits,of
R3191 T5090 T5089 prep in,deficits
R3192 T5091 T5090 pobj RanBP2,in
R3193 T5092 T5091 punct ", ",RanBP2
R3194 T5093 T5091 conj HKI,RanBP2
R3195 T5094 T5093 punct ", ",HKI
R3196 T5095 T5093 cc and,HKI
R3197 T5096 T5093 conj ATP,HKI
R3198 T5097 T5087 punct ", ",impact
R3199 T5098 T5087 prep on,impact
R3200 T5099 T5100 det the,responses
R3201 T5100 T5098 pobj responses,on
R3202 T5101 T5100 amod electrophysiological,responses
R3203 T5102 T5100 prep of,responses
R3204 T5103 T5104 nmod subclasses,neurons
R3205 T5104 T5102 pobj neurons,of
R3206 T5105 T5103 punct (,subclasses
R3207 T5106 T5103 appos rod,subclasses
R3208 T5107 T5106 cc and,rod
R3209 T5108 T5106 conj cone,rod
R3210 T5109 T5103 punct ),subclasses
R3211 T5110 T5104 nmod photoreceptor,neurons
R3212 T5111 T5110 cc and,photoreceptor
R3213 T5112 T5110 conj postreceptor,photoreceptor
R3214 T5113 T5104 amod retinal,neurons
R3215 T5114 T5104 prep of,neurons
R3216 T5115 T5114 pobj RanBP2,of
R3217 T5116 T5115 punct +,RanBP2
R3218 T5117 T5115 punct /,RanBP2
R3219 T5118 T5115 punct −,RanBP2
R3220 T5119 T5098 cc and,on
R3221 T5120 T5098 conj in,on
R3222 T5121 T5122 nmod RanBP2,mice
R3223 T5122 T5120 pobj mice,in
R3224 T5123 T5121 punct +,RanBP2
R3225 T5124 T5121 punct /,RanBP2
R3226 T5125 T5121 punct +,RanBP2
R3227 T5126 T5019 punct .,probed
R3228 T5128 T5129 det The,responses
R3229 T5129 T5136 nsubjpass responses,reduced
R3230 T5130 T5129 amod scotopic,responses
R3231 T5131 T5132 punct (,adapted
R3232 T5132 T5130 parataxis adapted,scotopic
R3233 T5133 T5132 npadvmod dark,adapted
R3234 T5134 T5132 punct -,adapted
R3235 T5135 T5132 punct ),adapted
R3236 T5137 T5129 acl mediated,responses
R3237 T5138 T5137 agent by,mediated
R3238 T5139 T5140 det the,pathway
R3239 T5140 T5138 pobj pathway,by
R3240 T5141 T5142 compound rod,photoreceptor
R3241 T5142 T5140 compound photoreceptor,pathway
R3242 T5143 T5140 prep at,pathway
R3243 T5144 T5145 amod low,stimulus
R3244 T5145 T5147 compound stimulus,intensities
R3245 T5146 T5145 punct -,stimulus
R3246 T5147 T5143 pobj intensities,at
R3247 T5148 T5140 cc and,pathway
R3248 T5149 T5150 amod mixed,pathways
R3249 T5150 T5140 conj pathways,pathway
R3250 T5151 T5150 nmod rod,pathways
R3251 T5152 T5151 cc and,rod
R3252 T5153 T5151 conj cone,rod
R3253 T5154 T5150 prep at,pathways
R3254 T5155 T5156 amod high,stimulus
R3255 T5156 T5158 compound stimulus,intensities
R3256 T5157 T5156 punct -,stimulus
R3257 T5158 T5154 pobj intensities,at
R3258 T5159 T5136 auxpass were,reduced
R3259 T5160 T5136 advmod substantially,reduced
R3260 T5161 T5136 prep in,reduced
R3261 T5162 T5163 nmod RanBP2,mice
R3262 T5163 T5161 pobj mice,in
R3263 T5164 T5162 punct +,RanBP2
R3264 T5165 T5162 punct /,RanBP2
R3265 T5166 T5162 punct −,RanBP2
R3266 T5167 T5168 punct (,8A
R3267 T5168 T5136 parataxis 8A,reduced
R3268 T5169 T5168 compound Figure,8A
R3269 T5170 T5168 punct ),8A
R3270 T5171 T5136 punct .,reduced
R3271 T5173 T5174 det The,differences
R3272 T5174 T5175 nsubj differences,were
R3273 T5176 T5174 prep in,differences
R3274 T5177 T5178 det the,responses
R3275 T5178 T5176 pobj responses,in
R3276 T5179 T5178 amod photopic,responses
R3277 T5180 T5181 punct (,adapted
R3278 T5181 T5179 parataxis adapted,photopic
R3279 T5182 T5181 npadvmod light,adapted
R3280 T5183 T5181 punct -,adapted
R3281 T5184 T5181 punct ),adapted
R3282 T5185 T5178 punct ", ",responses
R3283 T5186 T5178 acl initiated,responses
R3284 T5187 T5186 agent by,initiated
R3285 T5188 T5189 compound cone,photoreceptors
R3286 T5189 T5187 pobj photoreceptors,by
R3287 T5190 T5189 punct ", ",photoreceptors
R3288 T5191 T5192 dep which,make
R3289 T5192 T5189 relcl make,photoreceptors
R3290 T5193 T5192 prt up,make
R3291 T5194 T5195 nummod 3,%
R3292 T5195 T5192 dobj %,make
R3293 T5196 T5195 prep of,%
R3294 T5197 T5198 det the,neurons
R3295 T5198 T5196 pobj neurons,of
R3296 T5199 T5198 amod photosensory,neurons
R3297 T5200 T5198 prep in,neurons
R3298 T5201 T5202 det the,retina
R3299 T5202 T5200 pobj retina,in
R3300 T5203 T5202 compound mouse,retina
R3301 T5204 T5205 punct [,38
R3302 T5205 T5174 parataxis 38,differences
R3303 T5206 T5205 punct ],38
R3304 T5207 T5175 punct ", ",were
R3305 T5208 T5209 advmod less,obvious
R3306 T5209 T5175 acomp obvious,were
R3307 T5210 T5175 cc but,were
R3308 T5211 T5212 advmod still,exhibited
R3309 T5212 T5175 conj exhibited,were
R3310 T5213 T5214 det a,trend
R3311 T5214 T5212 dobj trend,exhibited
R3312 T5215 T5214 prep toward,trend
R3313 T5216 T5217 amod reduced,amplitudes
R3314 T5217 T5215 pobj amplitudes,toward
R3315 T5218 T5214 prep across,trend
R3316 T5219 T5220 det a,range
R3317 T5220 T5218 pobj range,across
R3318 T5221 T5220 prep of,range
R3319 T5222 T5223 amod increasing,intensities
R3320 T5223 T5221 pobj intensities,of
R3321 T5224 T5225 amod light,stimulus
R3322 T5225 T5223 compound stimulus,intensities
R3323 T5226 T5227 punct (,8B
R3324 T5227 T5212 parataxis 8B,exhibited
R3325 T5228 T5227 compound Figure,8B
R3326 T5229 T5227 punct ),8B
R3327 T5230 T5175 punct .,were
R3328 T5232 T5233 det The,reduction
R3329 T5233 T5234 nsubj reduction,included
R3330 T5235 T5233 prep in,reduction
R3331 T5236 T5237 det the,responses
R3332 T5237 T5235 pobj responses,in
R3333 T5238 T5237 amod scotopic,responses
R3334 T5239 T5234 dobj decreases,included
R3335 T5240 T5239 prep in,decreases
R3336 T5241 T5242 preconj both,wave
R3337 T5242 T5245 nmod wave,amplitudes
R3338 T5243 T5242 nmod b,wave
R3339 T5244 T5242 punct -,wave
R3340 T5245 T5240 pobj amplitudes,in
R3341 T5246 T5247 punct (,8C
R3342 T5247 T5242 parataxis 8C,wave
R3343 T5248 T5247 compound Figure,8C
R3344 T5249 T5247 punct ),8C
R3345 T5250 T5242 cc and,wave
R3346 T5251 T5252 compound a,wave
R3347 T5252 T5242 conj wave,wave
R3348 T5253 T5252 punct -,wave
R3349 T5254 T5255 punct (,8D
R3350 T5255 T5252 parataxis 8D,wave
R3351 T5256 T5255 compound Figure,8D
R3352 T5257 T5255 punct ),8D
R3353 T5258 T5245 acl mediated,amplitudes
R3354 T5259 T5258 agent by,mediated
R3355 T5260 T5261 amod postreceptoral,neurons
R3356 T5261 T5259 pobj neurons,by
R3357 T5262 T5260 cc and,postreceptoral
R3358 T5263 T5260 conj receptoral,postreceptoral
R3359 T5264 T5234 punct ", ",included
R3360 T5265 T5234 advmod respectively,included
R3361 T5266 T5234 punct .,included
R3362 T5268 T5269 amod Postreceptoral,responses
R3363 T5269 T5274 nsubj responses,tended
R3364 T5270 T5271 amod second,order
R3365 T5271 T5269 compound order,responses
R3366 T5272 T5271 punct -,order
R3367 T5273 T5269 compound neuron,responses
R3368 T5275 T5269 punct ", ",responses
R3369 T5276 T5269 acl represented,responses
R3370 T5277 T5276 agent by,represented
R3371 T5278 T5279 det the,wave
R3372 T5279 T5277 pobj wave,by
R3373 T5280 T5279 compound b,wave
R3374 T5281 T5279 punct -,wave
R3375 T5282 T5274 punct ", ",tended
R3376 T5283 T5284 aux to,be
R3377 T5284 T5274 xcomp be,tended
R3378 T5285 T5286 advmod more,reduced
R3379 T5286 T5284 acomp reduced,be
R3380 T5287 T5285 advmod consistently,more
R3381 T5288 T5287 cc and,consistently
R3382 T5289 T5287 conj substantially,consistently
R3383 T5290 T5286 prep than,reduced
R3384 T5291 T5292 det the,waves
R3385 T5292 T5290 pobj waves,than
R3386 T5293 T5292 compound a,waves
R3387 T5294 T5292 punct -,waves
R3388 T5295 T5292 punct ", ",waves
R3389 T5296 T5297 dep which,reflect
R3390 T5297 T5292 relcl reflect,waves
R3391 T5298 T5297 advmod directly,reflect
R3392 T5299 T5300 compound photoreceptor,activity
R3393 T5300 T5297 dobj activity,reflect
R3394 T5301 T5274 punct .,tended
R3395 T5303 T5304 mark Since,depend
R3396 T5304 T5310 advcl depend,suggests
R3397 T5305 T5306 amod second,order
R3398 T5306 T5308 compound order,responses
R3399 T5307 T5306 punct -,order
R3400 T5308 T5304 nsubj responses,depend
R3401 T5309 T5308 compound neuron,responses
R3402 T5311 T5304 prep on,depend
R3403 T5312 T5311 pobj input,on
R3404 T5313 T5312 prep from,input
R3405 T5314 T5313 pobj photoreceptors,from
R3406 T5315 T5310 punct ", ",suggests
R3407 T5316 T5310 nsubj this,suggests
R3408 T5317 T5318 mark that,are
R3409 T5318 T5310 ccomp are,suggests
R3410 T5319 T5320 amod reduced,amplitudes
R3411 T5320 T5318 nsubj amplitudes,are
R3412 T5321 T5322 compound b,wave
R3413 T5322 T5320 compound wave,amplitudes
R3414 T5323 T5322 punct -,wave
R3415 T5324 T5325 det the,result
R3416 T5325 T5318 attr result,are
R3417 T5326 T5325 prep of,result
R3418 T5327 T5328 det the,accumulation
R3419 T5328 T5326 pobj accumulation,of
R3420 T5329 T5328 prep of,accumulation
R3421 T5330 T5329 pobj decreases,of
R3422 T5331 T5330 prep in,decreases
R3423 T5332 T5333 det the,response
R3424 T5333 T5331 pobj response,in
R3425 T5334 T5333 amod light,response
R3426 T5335 T5333 prep of,response
R3427 T5336 T5337 preconj both,photoreceptors
R3428 T5337 T5335 pobj photoreceptors,of
R3429 T5338 T5337 cc and,photoreceptors
R3430 T5339 T5340 amod postreceptoral,neurons
R3431 T5340 T5337 conj neurons,photoreceptors
R3432 T5341 T5310 punct .,suggests
R3433 T5343 T5344 nsubj Anesthetics,cause
R3434 T5345 T5343 punct ", ",Anesthetics
R3435 T5346 T5347 advmod particularly,ketamine
R3436 T5347 T5343 appos ketamine,Anesthetics
R3437 T5348 T5344 punct ", ",cause
R3438 T5349 T5344 aux can,cause
R3439 T5350 T5351 amod sustained,elevation
R3440 T5351 T5344 dobj elevation,cause
R3441 T5352 T5351 prep of,elevation
R3442 T5353 T5352 pobj glucose,of
R3443 T5354 T5351 prep in,elevation
R3444 T5355 T5354 pobj mice,in
R3445 T5356 T5351 punct ", ",elevation
R3446 T5357 T5358 dep which,affects
R3447 T5358 T5351 relcl affects,elevation
R3448 T5359 T5358 prep in,affects
R3449 T5360 T5359 pobj turn,in
R3450 T5361 T5362 compound electroretinogram,responses
R3451 T5362 T5358 dobj responses,affects
R3452 T5363 T5364 punct [,39
R3453 T5364 T5358 parataxis 39,affects
R3454 T5365 T5364 punct ],39
R3455 T5366 T5344 punct .,cause
R3456 T5368 T5369 advmod Thus,were
R3457 T5370 T5369 punct ", ",were
R3458 T5371 T5369 nsubj we,were
R3459 T5372 T5369 acomp concerned,were
R3460 T5373 T5374 mark that,reflect
R3461 T5374 T5372 ccomp reflect,concerned
R3462 T5375 T5374 nsubj differences,reflect
R3463 T5376 T5375 prep in,differences
R3464 T5377 T5378 compound electroretinogram,amplitudes
R3465 T5378 T5376 pobj amplitudes,in
R3466 T5379 T5375 prep between,differences
R3467 T5380 T5379 pobj RanBP2,between
R3468 T5381 T5380 punct +,RanBP2
R3469 T5382 T5380 punct /,RanBP2
R3470 T5383 T5380 punct −,RanBP2
R3471 T5384 T5380 cc and,RanBP2
R3472 T5385 T5380 conj RanBP2,RanBP2
R3473 T5386 T5385 punct +,RanBP2
R3474 T5387 T5385 punct /,RanBP2
R3475 T5388 T5385 punct +,RanBP2
R3476 T5389 T5374 aux may,reflect
R3477 T5390 T5374 dobj differences,reflect
R3478 T5391 T5390 prep in,differences
R3479 T5392 T5393 compound glucose,level
R3480 T5393 T5394 compound level,changes
R3481 T5394 T5391 pobj changes,in
R3482 T5395 T5394 prep in,changes
R3483 T5396 T5395 pobj response,in
R3484 T5397 T5396 prep to,response
R3485 T5398 T5397 pobj anesthesia,to
R3486 T5399 T5369 punct .,were
R3487 T5401 T5402 advmod However,found
R3488 T5403 T5402 punct ", ",found
R3489 T5404 T5402 nsubj we,found
R3490 T5405 T5406 det no,differences
R3491 T5406 T5402 dobj differences,found
R3492 T5407 T5406 amod significant,differences
R3493 T5408 T5406 prep in,differences
R3494 T5409 T5410 compound glucose,levels
R3495 T5410 T5408 pobj levels,in
R3496 T5411 T5410 acl measured,levels
R3497 T5412 T5411 prep before,measured
R3498 T5413 T5411 cc and,measured
R3499 T5414 T5415 det every,min
R3500 T5415 T5417 npadvmod min,during
R3501 T5416 T5415 nummod 15,min
R3502 T5417 T5418 prep during,min
R3503 T5418 T5411 conj min,measured
R3504 T5419 T5418 nummod 75,min
R3505 T5420 T5418 prep of,min
R3506 T5421 T5420 pobj anesthesia,of
R3507 T5422 T5423 punct (,5
R3508 T5423 T5402 parataxis 5,found
R3509 T5424 T5423 nsubj n,5
R3510 T5425 T5423 punct =,5
R3511 T5426 T5423 quantmod 4,5
R3512 T5427 T5423 punct –,5
R3513 T5428 T5423 punct ),5
R3514 T5429 T5402 punct .,found
R3515 T5431 T5432 nsubj Glucose,rose
R3516 T5433 T5432 prep at,rose
R3517 T5434 T5435 det the,rate
R3518 T5435 T5433 pobj rate,at
R3519 T5436 T5435 amod same,rate
R3520 T5437 T5432 cc and,rose
R3521 T5438 T5432 conj reached,rose
R3522 T5439 T5440 det a,maximum
R3523 T5440 T5438 dobj maximum,reached
R3524 T5441 T5440 prep of,maximum
R3525 T5442 T5443 advmod approximately,3.3
R3526 T5443 T5444 nummod 3.3,level
R3527 T5444 T5441 pobj level,of
R3528 T5445 T5443 quantmod times,3.3
R3529 T5446 T5444 det the,level
R3530 T5447 T5444 amod pre-anesthesia,level
R3531 T5448 T5438 prep in,reached
R3532 T5449 T5450 det both,genotypes
R3533 T5450 T5448 pobj genotypes,in
R3534 T5451 T5452 punct (,data
R3535 T5452 T5438 meta data,reached
R3536 T5453 T5452 amod unpublished,data
R3537 T5454 T5452 punct ),data
R3538 T5455 T5432 punct .,rose
R9244 T14066 T14065 prep from,Electroretinograms
R9245 T14067 T14068 nummod 6,Mo
R9246 T14068 T14070 npadvmod Mo,Old
R9247 T14069 T14068 punct -,Mo
R9248 T14070 T14072 amod Old,Mice
R9249 T14071 T14070 punct -,Old
R9250 T14072 T14066 pobj Mice,from
R9251 T14073 T14072 nmod RanBP2,Mice
R9252 T14074 T14073 punct +,RanBP2
R9253 T14075 T14073 punct /,RanBP2
R9254 T14076 T14073 punct −,RanBP2
R9255 T14077 T14073 cc and,RanBP2
R9256 T14078 T14073 conj RanBP2,RanBP2
R9257 T14079 T14078 punct +,RanBP2
R9258 T14080 T14078 punct /,RanBP2
R9259 T14081 T14078 punct +,RanBP2
R9260 T14082 T14072 amod Inbred,Mice
R9261 T14083 T14072 acl Showing,Mice
R9262 T14084 T14085 nmod Photoreceptor,Neuron
R9263 T14085 T14088 nmod Neuron,Phenotypes
R9264 T14086 T14084 cc and,Photoreceptor
R9265 T14087 T14084 conj Postreceptor,Photoreceptor
R9266 T14088 T14083 dobj Phenotypes,Showing
R9267 T14089 T14090 amod Electrophysiological,Response
R9268 T14090 T14088 compound Response,Phenotypes
R9269 T14092 T14093 punct (,A
R9270 T14093 T14094 meta A,have
R9271 T14095 T14093 punct ),A
R9272 T14096 T14097 amod Scotopic,responses
R9273 T14097 T14094 nsubj responses,have
R9274 T14098 T14099 punct (,adapted
R9275 T14099 T14096 parataxis adapted,Scotopic
R9276 T14100 T14099 dep dark,adapted
R9277 T14101 T14099 punct -,adapted
R9278 T14102 T14099 punct ),adapted
R9279 T14103 T14097 prep from,responses
R9280 T14104 T14105 nmod RanBP2,mice
R9281 T14105 T14103 pobj mice,from
R9282 T14106 T14104 punct +,RanBP2
R9283 T14107 T14104 punct /,RanBP2
R9284 T14108 T14104 punct −,RanBP2
R9285 T14109 T14097 prep to,responses
R9286 T14110 T14111 amod light,stimuli
R9287 T14111 T14109 pobj stimuli,to
R9288 T14112 T14111 prep of,stimuli
R9289 T14113 T14114 amod increasing,intensity
R9290 T14114 T14112 pobj intensity,of
R9291 T14115 T14094 punct ", ",have
R9292 T14116 T14094 advcl beginning,have
R9293 T14117 T14116 prep at,beginning
R9294 T14118 T14117 pobj threshold,at
R9295 T14119 T14094 punct ", ",have
R9296 T14120 T14121 amod reduced,amplitudes
R9297 T14121 T14094 dobj amplitudes,have
R9298 T14122 T14094 prep compared,have
R9299 T14123 T14122 prep to,compared
R9300 T14124 T14123 pobj those,to
R9301 T14125 T14124 acl observed,those
R9302 T14126 T14125 prep in,observed
R9303 T14127 T14128 nmod RanBP2,mice
R9304 T14128 T14126 pobj mice,in
R9305 T14129 T14127 punct +,RanBP2
R9306 T14130 T14127 punct /,RanBP2
R9307 T14131 T14127 punct +,RanBP2
R9308 T14132 T14094 punct .,have
R9309 T14134 T14135 det The,intensities
R9310 T14135 T14138 nsubj intensities,represent
R9311 T14136 T14135 nummod three,intensities
R9312 T14137 T14135 amod lower,intensities
R9313 T14139 T14138 dobj responses,represent
R9314 T14140 T14139 acl generated,responses
R9315 T14141 T14140 prep in,generated
R9316 T14142 T14143 det the,pathway
R9317 T14143 T14141 pobj pathway,in
R9318 T14144 T14145 nmod rod,photoreceptor
R9319 T14145 T14143 nmod photoreceptor,pathway
R9320 T14146 T14143 amod neuronal,pathway
R9321 T14147 T14138 punct .,represent
R9322 T14149 T14150 det The,intensities
R9323 T14150 T14152 nsubjpass intensities,comprised
R9324 T14151 T14150 amod upper,intensities
R9325 T14153 T14152 auxpass are,comprised
R9326 T14154 T14152 prep of,comprised
R9327 T14155 T14154 pobj responses,of
R9328 T14156 T14155 acl generated,responses
R9329 T14157 T14156 prep in,generated
R9330 T14158 T14159 preconj both,pathways
R9331 T14159 T14157 pobj pathways,in
R9332 T14160 T14159 det the,pathways
R9333 T14161 T14159 nmod rod,pathways
R9334 T14162 T14161 cc and,rod
R9335 T14163 T14161 conj cone,rod
R9336 T14164 T14152 punct .,comprised
R9337 T14166 T14167 punct (,B
R9338 T14167 T14168 meta B,exhibited
R9339 T14169 T14167 punct ),B
R9340 T14170 T14171 amod Photopic,responses
R9341 T14171 T14168 nsubj responses,exhibited
R9342 T14172 T14173 punct (,pathway
R9343 T14173 T14170 parataxis pathway,Photopic
R9344 T14174 T14175 npadvmod light,adapted
R9345 T14175 T14173 amod adapted,pathway
R9346 T14176 T14175 punct -,adapted
R9347 T14177 T14173 punct ", ",pathway
R9348 T14178 T14179 compound cone,photoreceptor
R9349 T14179 T14173 compound photoreceptor,pathway
R9350 T14180 T14173 punct ),pathway
R9351 T14181 T14171 prep of,responses
R9352 T14182 T14183 nmod RanBP2,mice
R9353 T14183 T14181 pobj mice,of
R9354 T14184 T14182 punct +,RanBP2
R9355 T14185 T14182 punct /,RanBP2
R9356 T14186 T14182 punct −,RanBP2
R9357 T14187 T14171 prep to,responses
R9358 T14188 T14189 amod increasing,intensities
R9359 T14189 T14187 pobj intensities,to
R9360 T14190 T14191 amod light,stimulus
R9361 T14191 T14189 compound stimulus,intensities
R9362 T14192 T14168 advmod also,exhibited
R9363 T14193 T14194 amod reduced,amplitudes
R9364 T14194 T14168 dobj amplitudes,exhibited
R9365 T14195 T14168 prep compared,exhibited
R9366 T14196 T14195 prep to,compared
R9367 T14197 T14196 pobj those,to
R9368 T14198 T14197 acl observed,those
R9369 T14199 T14198 prep in,observed
R9370 T14200 T14201 nmod RanBP2,mice
R9371 T14201 T14199 pobj mice,in
R9372 T14202 T14200 punct +,RanBP2
R9373 T14203 T14200 punct /,RanBP2
R9374 T14204 T14200 punct +,RanBP2
R9375 T14205 T14168 punct .,exhibited
R9376 T14207 T14208 punct (,C
R9377 T14208 T14209 meta C,amplitudes
R9378 T14210 T14208 punct ),C
R9379 T14211 T14212 nmod Average,SE
R9380 T14212 T14209 nmod SE,amplitudes
R9381 T14213 T14212 punct ±,SE
R9382 T14214 T14215 punct (,9
R9383 T14215 T14212 parataxis 9,SE
R9384 T14216 T14215 nsubj n,9
R9385 T14217 T14215 punct =,9
R9386 T14218 T14215 punct ),9
R9387 T14219 T14209 amod scotopic,amplitudes
R9388 T14220 T14221 compound b,wave
R9389 T14221 T14209 compound wave,amplitudes
R9390 T14222 T14221 punct -,wave
R9391 T14223 T14209 prep from,amplitudes
R9392 T14224 T14225 nmod RanBP2,mice
R9393 T14225 T14223 pobj mice,from
R9394 T14226 T14224 punct +,RanBP2
R9395 T14227 T14224 punct /,RanBP2
R9396 T14228 T14224 punct −,RanBP2
R9397 T14229 T14230 punct (,circles
R9398 T14230 T14224 parataxis circles,RanBP2
R9399 T14231 T14230 amod open,circles
R9400 T14232 T14230 punct ),circles
R9401 T14233 T14224 cc and,RanBP2
R9402 T14234 T14224 conj RanBP2,RanBP2
R9403 T14235 T14234 punct +,RanBP2
R9404 T14236 T14234 punct /,RanBP2
R9405 T14237 T14234 punct +,RanBP2
R9406 T14238 T14239 punct (,squares
R9407 T14239 T14234 parataxis squares,RanBP2
R9408 T14240 T14239 amod filled,squares
R9409 T14241 T14239 punct ),squares
R9410 T14242 T14209 acl representing,amplitudes
R9411 T14243 T14244 amod postreceptoral,neuron
R9412 T14244 T14245 compound neuron,function
R9413 T14245 T14242 dobj function,representing
R9414 T14246 T14209 punct .,amplitudes
R9415 T14248 T14249 punct (,scale
R9416 T14250 T14249 dep Note,scale
R9417 T14251 T14249 punct : ,scale
R9418 T14252 T14253 compound log,amplitude
R9419 T14253 T14249 compound amplitude,scale
R9420 T14254 T14249 punct .,scale
R9421 T14255 T14249 punct ),scale
R9422 T14257 T14258 punct (,D
R9423 T14258 T14259 meta D,amplitudes
R9424 T14260 T14258 punct ),D
R9425 T14261 T14262 amod Average,SE
R9426 T14262 T14259 nmod SE,amplitudes
R9427 T14263 T14262 punct ±,SE
R9428 T14264 T14265 punct (,5
R9429 T14265 T14262 parataxis 5,SE
R9430 T14266 T14265 nsubj n,5
R9431 T14267 T14265 punct =,5
R9432 T14268 T14265 punct ),5
R9433 T14269 T14259 amod scotopic,amplitudes
R9434 T14270 T14271 compound a,wave
R9435 T14271 T14259 compound wave,amplitudes
R9436 T14272 T14271 punct -,wave
R9437 T14273 T14259 punct ", ",amplitudes
R9438 T14274 T14259 acl representing,amplitudes
R9439 T14275 T14276 compound photoreceptor,function
R9440 T14276 T14274 dobj function,representing
R9441 T14277 T14274 punct ", ",representing
R9442 T14278 T14274 prep for,representing
R9443 T14279 T14280 nmod RanBP2,mice
R9444 T14280 T14278 pobj mice,for
R9445 T14281 T14279 punct +,RanBP2
R9446 T14282 T14279 punct /,RanBP2
R9447 T14283 T14279 punct −,RanBP2
R9448 T14284 T14279 cc and,RanBP2
R9449 T14285 T14279 conj RanBP2,RanBP2
R9450 T14286 T14285 punct +,RanBP2
R9451 T14287 T14285 punct /,RanBP2
R9452 T14288 T14285 punct +,RanBP2
R9453 T14289 T14274 prep in,representing
R9454 T14290 T14289 pobj response,in
R9455 T14291 T14290 prep to,response
R9456 T14292 T14293 amod bright,flashes
R9457 T14293 T14291 pobj flashes,to
R9458 T14294 T14259 punct .,amplitudes
R9459 T14296 T14297 nsubj Amplitudes,were
R9460 T14298 T14296 prep of,Amplitudes
R9461 T14299 T14298 pobj responses,of
R9462 T14300 T14299 prep from,responses
R9463 T14301 T14302 nmod RanBP2,mice
R9464 T14302 T14300 pobj mice,from
R9465 T14303 T14301 punct +,RanBP2
R9466 T14304 T14301 punct /,RanBP2
R9467 T14305 T14301 punct −,RanBP2
R9468 T14306 T14297 acomp lower,were
R9469 T14307 T14297 prep over,were
R9470 T14308 T14309 det the,range
R9471 T14309 T14307 pobj range,over
R9472 T14310 T14309 amod entire,range
R9473 T14311 T14309 prep of,range
R9474 T14312 T14313 compound stimulus,intensities
R9475 T14313 T14311 pobj intensities,of
R9476 T14314 T14313 prep for,intensities
R9477 T14315 T14316 preconj both,b
R9478 T14316 T14317 nmod b,waves
R9479 T14317 T14314 pobj waves,for
R9480 T14318 T14316 punct -,b
R9481 T14319 T14316 cc and,b
R9482 T14320 T14316 conj a,b
R9483 T14321 T14320 punct -,a
R9484 T14322 T14297 punct .,were
R9485 T14324 T14325 nsubj Asterisks,represent
R9486 T14326 T14327 amod significant,differences
R9487 T14327 T14325 dobj differences,represent
R9488 T14328 T14327 prep between,differences
R9489 T14329 T14330 det the,groups
R9490 T14330 T14328 pobj groups,between
R9491 T14331 T14332 punct (,test
R9492 T14332 T14325 parataxis test,represent
R9493 T14333 T14332 poss Student,test
R9494 T14334 T14333 case 's,Student
R9495 T14335 T14332 compound t,test
R9496 T14336 T14332 punct ", ",test
R9497 T14337 T14338 nsubj p,0.05
R9498 T14338 T14332 ccomp 0.05,test
R9499 T14339 T14338 punct <,0.05
R9500 T14340 T14332 punct ),test
R9501 T14341 T14325 punct .,represent
R9502 T14343 T14344 amod Statistical,significance
R9503 T14344 T14345 nsubjpass significance,found
R9504 T14346 T14345 auxpass was,found
R9505 T14347 T14345 prep across,found
R9506 T14348 T14349 det all,intensities
R9507 T14349 T14347 pobj intensities,across
R9508 T14350 T14345 prep for,found
R9509 T14351 T14352 compound b,wave
R9510 T14352 T14354 compound wave,amplitudes
R9511 T14353 T14352 punct -,wave
R9512 T14354 T14350 pobj amplitudes,for
R9513 T14355 T14356 punct (,ANOVA
R9514 T14356 T14354 parataxis ANOVA,amplitudes
R9515 T14357 T14358 nummod 2,way
R9516 T14358 T14356 compound way,ANOVA
R9517 T14359 T14358 punct -,way
R9518 T14360 T14356 punct ", ",ANOVA
R9519 T14361 T14362 nsubj p,0.0001
R9520 T14362 T14356 ccomp 0.0001,ANOVA
R9521 T14363 T14362 punct <,0.0001
R9522 T14364 T14356 punct ),ANOVA
R9523 T14365 T14350 punct ", ",for
R9524 T14366 T14350 cc but,for
R9525 T14367 T14366 neg not,but
R9526 T14368 T14350 conj for,for
R9527 T14369 T14370 det the,wave
R9528 T14370 T14368 pobj wave,for
R9529 T14371 T14370 compound a,wave
R9530 T14372 T14370 punct -,wave
R9531 T14373 T14345 punct .,found