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PMC:1626108 / 20747-22725 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3641 0-2 IN denotes In
T3643 3-8 NN denotes light
T3644 9-11 IN denotes of
T3645 12-15 DT denotes the
T3646 16-27 NN denotes association
T3647 28-30 FW denotes in
T3648 31-35 FW denotes vivo
T3649 36-38 IN denotes of
T3650 39-45 NN denotes RanBP2
T3651 46-50 IN denotes with
T3652 51-56 NN denotes Cox11
T3653 57-60 CC denotes and
T3654 61-64 NN denotes HKI
T3655 65-66 -LRB- denotes (
T3657 66-73 NNS denotes Figures
T3656 74-75 CD denotes 1
T3658 76-79 CC denotes and
T3659 80-81 CD denotes 3
T3660 81-82 -RRB- denotes )
T3661 82-84 , denotes ,
T3662 84-92 JJ denotes profound
T3664 93-95 FW denotes in
T3665 96-101 FW denotes vitro
T3663 102-112 NN denotes modulation
T3666 113-115 IN denotes of
T3667 116-119 NN denotes HKI
T3668 120-129 JJ denotes enzymatic
T3669 130-138 NN denotes activity
T3670 139-141 IN denotes by
T3671 142-148 NN denotes RanBP2
T3672 149-152 CC denotes and
T3673 153-158 NN denotes Cox11
T3674 159-160 -LRB- denotes (
T3675 160-166 NN denotes Figure
T3676 167-168 CD denotes 2
T3677 168-169 -RRB- denotes )
T3678 169-171 , denotes ,
T3679 171-174 CC denotes and
T3680 175-178 DT denotes the
T3682 179-187 JJ denotes critical
T3681 188-192 NN denotes role
T3683 193-195 IN denotes of
T3684 196-199 NN denotes HKI
T3685 200-202 IN denotes in
T3686 203-213 VBG denotes catalyzing
T3687 214-215 DT denotes a
T3689 216-220 NN denotes rate
T3691 220-221 HYPH denotes -
T3690 221-229 VBG denotes limiting
T3688 230-234 NN denotes step
T3692 235-237 IN denotes of
T3693 238-248 NN denotes glycolysis
T3694 248-250 , denotes ,
T3695 250-252 PRP denotes we
T3642 253-259 VBD denotes probed
T3696 260-267 IN denotes whether
T3698 268-274 NN denotes RanBP2
T3700 274-275 SYM denotes +
T3701 275-276 HYPH denotes /
T3702 276-277 SYM denotes −
T3699 278-282 NNS denotes mice
T3697 283-292 VBD denotes presented
T3703 293-305 NNS denotes disturbances
T3704 306-308 IN denotes in
T3705 309-312 NN denotes HKI
T3706 312-314 , denotes ,
T3707 314-319 NN denotes Cox11
T3708 319-321 , denotes ,
T3709 321-324 CC denotes and
T3710 325-331 NN denotes energy
T3711 332-343 NN denotes homeostasis
T3712 343-344 . denotes .
T3713 344-673 sentence denotes Monoallelic expression of RanBP2 does not affect the number of NPCs and their distribution in hippocampal neurons (Figure 5A, unpublished data), but it led to consistent lower expression of RanBP2 by more than 50% in the CNS (brain and retina) in 129Ola (Figure 5B–5D), but not in C57BL/6J/129Ola backgrounds (unpublished data).
T3714 345-356 JJ denotes Monoallelic
T3715 357-367 NN denotes expression
T3717 368-370 IN denotes of
T3718 371-377 NN denotes RanBP2
T3719 378-382 VBZ denotes does
T3720 383-386 RB denotes not
T3716 387-393 VB denotes affect
T3721 394-397 DT denotes the
T3722 398-404 NN denotes number
T3723 405-407 IN denotes of
T3724 408-412 NNS denotes NPCs
T3725 413-416 CC denotes and
T3726 417-422 PRP$ denotes their
T3727 423-435 NN denotes distribution
T3728 436-438 IN denotes in
T3729 439-450 JJ denotes hippocampal
T3730 451-458 NNS denotes neurons
T3731 459-460 -LRB- denotes (
T3733 460-466 NN denotes Figure
T3734 467-469 NN denotes 5A
T3735 469-471 , denotes ,
T3736 471-482 JJ denotes unpublished
T3732 483-487 NNS denotes data
T3737 487-488 -RRB- denotes )
T3738 488-490 , denotes ,
T3739 490-493 CC denotes but
T3740 494-496 PRP denotes it
T3741 497-500 VBD denotes led
T3742 501-503 IN denotes to
T3743 504-514 JJ denotes consistent
T3745 515-520 JJR denotes lower
T3744 521-531 NN denotes expression
T3746 532-534 IN denotes of
T3747 535-541 NN denotes RanBP2
T3748 542-544 IN denotes by
T3749 545-549 JJR denotes more
T3751 550-554 IN denotes than
T3750 555-557 CD denotes 50
T3752 557-558 NN denotes %
T3753 559-561 IN denotes in
T3754 562-565 DT denotes the
T3755 566-569 NN denotes CNS
T3756 570-571 -LRB- denotes (
T3757 571-576 NN denotes brain
T3758 577-580 CC denotes and
T3759 581-587 NN denotes retina
T3760 587-588 -RRB- denotes )
T3761 589-591 IN denotes in
T3762 592-598 NN denotes 129Ola
T3763 599-600 -LRB- denotes (
T3765 600-606 NN denotes Figure
T3764 607-609 NN denotes 5B
T3766 609-610 SYM denotes –
T3767 610-612 NN denotes 5D
T3768 612-613 -RRB- denotes )
T3769 613-615 , denotes ,
T3770 615-618 CC denotes but
T3771 619-622 RB denotes not
T3772 623-625 IN denotes in
T3773 626-631 NN denotes C57BL
T3775 631-632 HYPH denotes /
T3776 632-634 NN denotes 6J
T3777 634-635 HYPH denotes /
T3774 635-641 NN denotes 129Ola
T3778 642-653 NNS denotes backgrounds
T3779 654-655 -LRB- denotes (
T3781 655-666 JJ denotes unpublished
T3780 667-671 NNS denotes data
T3782 671-672 -RRB- denotes )
T3783 672-673 . denotes .
T3784 673-747 sentence denotes Hence, we focused our analysis on the inbred RanBP2+/− 129Ola mouse line.
T3785 674-679 RB denotes Hence
T3787 679-681 , denotes ,
T3788 681-683 PRP denotes we
T3786 684-691 VBD denotes focused
T3789 692-695 PRP$ denotes our
T3790 696-704 NN denotes analysis
T3791 705-707 IN denotes on
T3792 708-711 DT denotes the
T3794 712-718 JJ denotes inbred
T3795 719-725 NN denotes RanBP2
T3796 725-726 SYM denotes +
T3797 726-727 HYPH denotes /
T3798 727-728 SYM denotes −
T3799 729-735 NN denotes 129Ola
T3800 736-741 NN denotes mouse
T3793 742-746 NN denotes line
T3801 746-747 . denotes .
T3802 747-1004 sentence denotes Although the levels of RanBP2 were decreased in the retina, brain, and hippocampus of RanBP2+/−mice by ~50%–60% (Figure 5B and 5C), the levels of others nucleoporins, Nup153 and Nup62, and mHsp70 and Cox11, remained unchanged (Figure 5B, unpublished data).
T3803 748-756 IN denotes Although
T3805 757-760 DT denotes the
T3806 761-767 NNS denotes levels
T3807 768-770 IN denotes of
T3808 771-777 NN denotes RanBP2
T3809 778-782 VBD denotes were
T3804 783-792 VBN denotes decreased
T3811 793-795 IN denotes in
T3812 796-799 DT denotes the
T3813 800-806 NN denotes retina
T3814 806-808 , denotes ,
T3815 808-813 NN denotes brain
T3816 813-815 , denotes ,
T3817 815-818 CC denotes and
T3818 819-830 NN denotes hippocampus
T3819 831-833 IN denotes of
T3820 834-840 NN denotes RanBP2
T3822 840-841 SYM denotes +
T3823 841-842 HYPH denotes /
T3824 842-843 SYM denotes −
T3821 843-847 NNS denotes mice
T3825 848-850 IN denotes by
T3826 851-852 SYM denotes ~
T3827 852-854 CD denotes 50
T3828 854-855 NN denotes %
T3829 855-856 SYM denotes –
T3831 856-858 CD denotes 60
T3830 858-859 NN denotes %
T3832 860-861 -LRB- denotes (
T3834 861-867 NN denotes Figure
T3833 868-870 NN denotes 5B
T3835 871-874 CC denotes and
T3836 875-877 NN denotes 5C
T3837 877-878 -RRB- denotes )
T3838 878-880 , denotes ,
T3839 880-883 DT denotes the
T3840 884-890 NNS denotes levels
T3841 891-893 IN denotes of
T3842 894-900 NNS denotes others
T3843 901-913 NNS denotes nucleoporins
T3844 913-915 , denotes ,
T3845 915-921 NN denotes Nup153
T3846 922-925 CC denotes and
T3847 926-931 NN denotes Nup62
T3848 931-933 , denotes ,
T3849 933-936 CC denotes and
T3850 937-943 NN denotes mHsp70
T3851 944-947 CC denotes and
T3852 948-953 NN denotes Cox11
T3853 953-955 , denotes ,
T3810 955-963 VBD denotes remained
T3854 964-973 JJ denotes unchanged
T3855 974-975 -LRB- denotes (
T3857 975-981 NN denotes Figure
T3858 982-984 NN denotes 5B
T3859 984-986 , denotes ,
T3860 986-997 JJ denotes unpublished
T3856 998-1002 NNS denotes data
T3861 1002-1003 -RRB- denotes )
T3862 1003-1004 . denotes .
T3863 1004-1103 sentence denotes In addition, we observed a strong decrease of the levels of HKI (3- to 4-fold) (Figure 5B and 5C).
T3864 1005-1007 IN denotes In
T3866 1008-1016 NN denotes addition
T3867 1016-1018 , denotes ,
T3868 1018-1020 PRP denotes we
T3865 1021-1029 VBD denotes observed
T3869 1030-1031 DT denotes a
T3871 1032-1038 JJ denotes strong
T3870 1039-1047 NN denotes decrease
T3872 1048-1050 IN denotes of
T3873 1051-1054 DT denotes the
T3874 1055-1061 NNS denotes levels
T3875 1062-1064 IN denotes of
T3876 1065-1068 NN denotes HKI
T3877 1069-1070 -LRB- denotes (
T3878 1070-1071 CD denotes 3
T3879 1071-1072 HYPH denotes -
T3880 1073-1075 IN denotes to
T3881 1076-1082 RB denotes 4-fold
T3882 1082-1083 -RRB- denotes )
T3883 1084-1085 -LRB- denotes (
T3885 1085-1091 NN denotes Figure
T3884 1092-1094 NN denotes 5B
T3886 1095-1098 CC denotes and
T3887 1099-1101 NN denotes 5C
T3888 1101-1102 -RRB- denotes )
T3889 1102-1103 . denotes .
T3890 1103-1243 sentence denotes This decrease was selective to the CNS, since HKI levels remained largely unaffected in the skeletal muscle, spleen, and liver (Figure 5D).
T3891 1104-1108 DT denotes This
T3892 1109-1117 NN denotes decrease
T3893 1118-1121 VBD denotes was
T3894 1122-1131 JJ denotes selective
T3895 1132-1134 IN denotes to
T3896 1135-1138 DT denotes the
T3897 1139-1142 NN denotes CNS
T3898 1142-1144 , denotes ,
T3899 1144-1149 IN denotes since
T3901 1150-1153 NN denotes HKI
T3902 1154-1160 NNS denotes levels
T3900 1161-1169 VBD denotes remained
T3903 1170-1177 RB denotes largely
T3904 1178-1188 JJ denotes unaffected
T3905 1189-1191 IN denotes in
T3906 1192-1195 DT denotes the
T3908 1196-1204 JJ denotes skeletal
T3907 1205-1211 NN denotes muscle
T3909 1211-1213 , denotes ,
T3910 1213-1219 NN denotes spleen
T3911 1219-1221 , denotes ,
T3912 1221-1224 CC denotes and
T3913 1225-1230 NN denotes liver
T3914 1231-1232 -LRB- denotes (
T3916 1232-1238 NN denotes Figure
T3915 1239-1241 NN denotes 5D
T3917 1241-1242 -RRB- denotes )
T3918 1242-1243 . denotes .
T3919 1243-1466 sentence denotes Because HKI plays a key role in the production of energy intermediate substrates and HKI is virtually the sole HK isoform expressed in the CNS [33,34], we probed the impact of HKI and RanBP2 reduction in the levels of ATP.
T3920 1244-1251 IN denotes Because
T3922 1252-1255 NN denotes HKI
T3921 1256-1261 VBZ denotes plays
T3924 1262-1263 DT denotes a
T3926 1264-1267 JJ denotes key
T3925 1268-1272 NN denotes role
T3927 1273-1275 IN denotes in
T3928 1276-1279 DT denotes the
T3929 1280-1290 NN denotes production
T3930 1291-1293 IN denotes of
T3931 1294-1300 NN denotes energy
T3933 1301-1313 JJ denotes intermediate
T3932 1314-1324 NNS denotes substrates
T3934 1325-1328 CC denotes and
T3935 1329-1332 NN denotes HKI
T3936 1333-1335 VBZ denotes is
T3937 1336-1345 RB denotes virtually
T3939 1346-1349 DT denotes the
T3940 1350-1354 JJ denotes sole
T3941 1355-1357 NN denotes HK
T3938 1358-1365 NN denotes isoform
T3942 1366-1375 VBN denotes expressed
T3943 1376-1378 IN denotes in
T3944 1379-1382 DT denotes the
T3945 1383-1386 NN denotes CNS
T3946 1387-1388 -LRB- denotes [
T3948 1388-1390 CD denotes 33
T3949 1390-1391 , denotes ,
T3947 1391-1393 CD denotes 34
T3950 1393-1394 -RRB- denotes ]
T3951 1394-1396 , denotes ,
T3952 1396-1398 PRP denotes we
T3923 1399-1405 VBD denotes probed
T3953 1406-1409 DT denotes the
T3954 1410-1416 NN denotes impact
T3955 1417-1419 IN denotes of
T3956 1420-1423 NN denotes HKI
T3958 1424-1427 CC denotes and
T3959 1428-1434 NN denotes RanBP2
T3957 1435-1444 NN denotes reduction
T3960 1445-1447 IN denotes in
T3961 1448-1451 DT denotes the
T3962 1452-1458 NNS denotes levels
T3963 1459-1461 IN denotes of
T3964 1462-1465 NN denotes ATP
T3965 1465-1466 . denotes .
T3966 1466-1617 sentence denotes As shown in Figure 5E, there was significant and concordant reduction in levels of ATP in the CNS (brain and retina), but not in non-neuronal tissues.
T3967 1467-1469 IN denotes As
T3968 1470-1475 VBN denotes shown
T3970 1476-1478 IN denotes in
T3971 1479-1485 NN denotes Figure
T3972 1486-1488 NN denotes 5E
T3973 1488-1490 , denotes ,
T3974 1490-1495 EX denotes there
T3969 1496-1499 VBD denotes was
T3975 1500-1511 JJ denotes significant
T3977 1512-1515 CC denotes and
T3978 1516-1526 JJ denotes concordant
T3976 1527-1536 NN denotes reduction
T3979 1537-1539 IN denotes in
T3980 1540-1546 NNS denotes levels
T3981 1547-1549 IN denotes of
T3982 1550-1553 NN denotes ATP
T3983 1554-1556 IN denotes in
T3984 1557-1560 DT denotes the
T3985 1561-1564 NN denotes CNS
T3986 1565-1566 -LRB- denotes (
T3987 1566-1571 NN denotes brain
T3988 1572-1575 CC denotes and
T3989 1576-1582 NN denotes retina
T3990 1582-1583 -RRB- denotes )
T3991 1583-1585 , denotes ,
T3992 1585-1588 CC denotes but
T3993 1589-1592 RB denotes not
T3994 1593-1595 IN denotes in
T3995 1596-1608 JJ denotes non-neuronal
T3996 1609-1616 NNS denotes tissues
T3997 1616-1617 . denotes .
T3998 1617-1837 sentence denotes Finally, we also observed partial and selective delocalization of HKI, but not of Cox11, from the ellipsoid (mitochondria-rich) to the adjacent myoid subcellular compartment of rod photosensory neurons (Figure S2A–S2E).
T3999 1618-1625 RB denotes Finally
T4001 1625-1627 , denotes ,
T4002 1627-1629 PRP denotes we
T4003 1630-1634 RB denotes also
T4000 1635-1643 VBD denotes observed
T4004 1644-1651 JJ denotes partial
T4006 1652-1655 CC denotes and
T4007 1656-1665 JJ denotes selective
T4005 1666-1680 NN denotes delocalization
T4008 1681-1683 IN denotes of
T4009 1684-1687 NN denotes HKI
T4010 1687-1689 , denotes ,
T4011 1689-1692 CC denotes but
T4012 1693-1696 RB denotes not
T4013 1697-1699 IN denotes of
T4014 1700-1705 NN denotes Cox11
T4015 1705-1707 , denotes ,
T4016 1707-1711 IN denotes from
T4017 1712-1715 DT denotes the
T4018 1716-1725 JJ denotes ellipsoid
T4019 1726-1727 -LRB- denotes (
T4020 1727-1739 NNS denotes mitochondria
T4022 1739-1740 HYPH denotes -
T4021 1740-1744 JJ denotes rich
T4023 1744-1745 -RRB- denotes )
T4024 1746-1748 IN denotes to
T4025 1749-1752 DT denotes the
T4027 1753-1761 JJ denotes adjacent
T4026 1762-1767 JJ denotes myoid
T4028 1768-1779 JJ denotes subcellular
T4029 1780-1791 NN denotes compartment
T4030 1792-1794 IN denotes of
T4031 1795-1798 NN denotes rod
T4033 1799-1811 JJ denotes photosensory
T4032 1812-1819 NNS denotes neurons
T4034 1820-1821 -LRB- denotes (
T4036 1821-1827 NN denotes Figure
T4035 1828-1831 NN denotes S2A
T4037 1831-1832 SYM denotes –
T4038 1832-1835 NN denotes S2E
T4039 1835-1836 -RRB- denotes )
T4040 1836-1837 . denotes .
T4041 1837-1978 sentence denotes This was also accompanied by reduced HKI levels in the inner retina, in particular in the inner plexiform (synaptic) layer (Figure S2A–S2E).
T4042 1838-1842 DT denotes This
T4044 1843-1846 VBD denotes was
T4045 1847-1851 RB denotes also
T4043 1852-1863 VBN denotes accompanied
T4046 1864-1866 IN denotes by
T4047 1867-1874 VBN denotes reduced
T4049 1875-1878 NN denotes HKI
T4048 1879-1885 NNS denotes levels
T4050 1886-1888 IN denotes in
T4051 1889-1892 DT denotes the
T4053 1893-1898 JJ denotes inner
T4052 1899-1905 NN denotes retina
T4054 1905-1907 , denotes ,
T4055 1907-1909 IN denotes in
T4057 1910-1920 JJ denotes particular
T4056 1921-1923 IN denotes in
T4058 1924-1927 DT denotes the
T4060 1928-1933 JJ denotes inner
T4061 1934-1943 JJ denotes plexiform
T4062 1944-1945 -LRB- denotes (
T4063 1945-1953 JJ denotes synaptic
T4064 1953-1954 -RRB- denotes )
T4059 1955-1960 NN denotes layer
T4065 1961-1962 -LRB- denotes (
T4067 1962-1968 NN denotes Figure
T4066 1969-1972 NN denotes S2A
T4068 1972-1973 SYM denotes –
T4069 1973-1976 NN denotes S2E
T4070 1976-1977 -RRB- denotes )
T4071 1977-1978 . denotes .
R2210 T3641 T3642 prep In,probed
R2211 T3643 T3641 pobj light,In
R2212 T3644 T3643 prep of,light
R2213 T3645 T3646 det the,association
R2214 T3646 T3644 pobj association,of
R2215 T3647 T3648 advmod in,vivo
R2216 T3648 T3646 advmod vivo,association
R2217 T3649 T3646 prep of,association
R2218 T3650 T3649 pobj RanBP2,of
R2219 T3651 T3646 prep with,association
R2220 T3652 T3651 pobj Cox11,with
R2221 T3653 T3652 cc and,Cox11
R2222 T3654 T3652 conj HKI,Cox11
R2223 T3655 T3656 punct (,1
R2224 T3656 T3646 parataxis 1,association
R2225 T3657 T3656 nmod Figures,1
R2226 T3658 T3656 cc and,1
R2227 T3659 T3656 conj 3,1
R2228 T3660 T3656 punct ),1
R2229 T3661 T3646 punct ", ",association
R2230 T3662 T3663 amod profound,modulation
R2231 T3663 T3646 conj modulation,association
R2232 T3664 T3665 advmod in,vitro
R2233 T3665 T3663 amod vitro,modulation
R2234 T3666 T3663 prep of,modulation
R2235 T3667 T3668 npadvmod HKI,enzymatic
R2236 T3668 T3669 amod enzymatic,activity
R2237 T3669 T3666 pobj activity,of
R2238 T3670 T3663 prep by,modulation
R2239 T3671 T3670 pobj RanBP2,by
R2240 T3672 T3671 cc and,RanBP2
R2241 T3673 T3671 conj Cox11,RanBP2
R2242 T3674 T3675 punct (,Figure
R2243 T3675 T3663 parataxis Figure,modulation
R2244 T3676 T3675 nummod 2,Figure
R2245 T3677 T3675 punct ),Figure
R2246 T3678 T3663 punct ", ",modulation
R2247 T3679 T3663 cc and,modulation
R2248 T3680 T3681 det the,role
R2249 T3681 T3663 conj role,modulation
R2250 T3682 T3681 amod critical,role
R2251 T3683 T3681 prep of,role
R2252 T3684 T3683 pobj HKI,of
R2253 T3685 T3681 prep in,role
R2254 T3686 T3685 pcomp catalyzing,in
R2255 T3687 T3688 det a,step
R2256 T3688 T3686 dobj step,catalyzing
R2257 T3689 T3690 npadvmod rate,limiting
R2258 T3690 T3688 amod limiting,step
R2259 T3691 T3690 punct -,limiting
R2260 T3692 T3688 prep of,step
R2261 T3693 T3692 pobj glycolysis,of
R2262 T3694 T3642 punct ", ",probed
R2263 T3695 T3642 nsubj we,probed
R2264 T3696 T3697 mark whether,presented
R2265 T3697 T3642 ccomp presented,probed
R2266 T3698 T3699 nmod RanBP2,mice
R2267 T3699 T3697 nsubj mice,presented
R2268 T3700 T3698 punct +,RanBP2
R2269 T3701 T3698 punct /,RanBP2
R2270 T3702 T3698 punct −,RanBP2
R2271 T3703 T3697 dobj disturbances,presented
R2272 T3704 T3703 prep in,disturbances
R2273 T3705 T3704 pobj HKI,in
R2274 T3706 T3705 punct ", ",HKI
R2275 T3707 T3705 conj Cox11,HKI
R2276 T3708 T3707 punct ", ",Cox11
R2277 T3709 T3707 cc and,Cox11
R2278 T3710 T3711 compound energy,homeostasis
R2279 T3711 T3707 conj homeostasis,Cox11
R2280 T3712 T3642 punct .,probed
R2281 T3714 T3715 amod Monoallelic,expression
R2282 T3715 T3716 nsubj expression,affect
R2283 T3717 T3715 prep of,expression
R2284 T3718 T3717 pobj RanBP2,of
R2285 T3719 T3716 aux does,affect
R2286 T3720 T3716 neg not,affect
R2287 T3721 T3722 det the,number
R2288 T3722 T3716 dobj number,affect
R2289 T3723 T3722 prep of,number
R2290 T3724 T3723 pobj NPCs,of
R2291 T3725 T3722 cc and,number
R2292 T3726 T3727 poss their,distribution
R2293 T3727 T3722 conj distribution,number
R2294 T3728 T3727 prep in,distribution
R2295 T3729 T3730 amod hippocampal,neurons
R2296 T3730 T3728 pobj neurons,in
R2297 T3731 T3732 punct (,data
R2298 T3732 T3716 parataxis data,affect
R2299 T3733 T3734 compound Figure,5A
R2300 T3734 T3732 dep 5A,data
R2301 T3735 T3732 punct ", ",data
R2302 T3736 T3732 amod unpublished,data
R2303 T3737 T3732 punct ),data
R2304 T3738 T3716 punct ", ",affect
R2305 T3739 T3716 cc but,affect
R2306 T3740 T3741 nsubj it,led
R2307 T3741 T3716 conj led,affect
R2308 T3742 T3741 prep to,led
R2309 T3743 T3744 amod consistent,expression
R2310 T3744 T3742 pobj expression,to
R2311 T3745 T3744 amod lower,expression
R2312 T3746 T3744 prep of,expression
R2313 T3747 T3746 pobj RanBP2,of
R2314 T3748 T3744 prep by,expression
R2315 T3749 T3750 amod more,50
R2316 T3750 T3752 nummod 50,%
R2317 T3751 T3750 quantmod than,50
R2318 T3752 T3748 pobj %,by
R2319 T3753 T3744 prep in,expression
R2320 T3754 T3755 det the,CNS
R2321 T3755 T3753 pobj CNS,in
R2322 T3756 T3755 punct (,CNS
R2323 T3757 T3755 appos brain,CNS
R2324 T3758 T3757 cc and,brain
R2325 T3759 T3757 conj retina,brain
R2326 T3760 T3755 punct ),CNS
R2327 T3761 T3755 prep in,CNS
R2328 T3762 T3761 pobj 129Ola,in
R2329 T3763 T3764 punct (,5B
R2330 T3764 T3762 parataxis 5B,129Ola
R2331 T3765 T3764 compound Figure,5B
R2332 T3766 T3767 punct –,5D
R2333 T3767 T3764 prep 5D,5B
R2334 T3768 T3764 punct ),5B
R2335 T3769 T3761 punct ", ",in
R2336 T3770 T3761 cc but,in
R2337 T3771 T3770 neg not,but
R2338 T3772 T3761 conj in,in
R2339 T3773 T3774 compound C57BL,129Ola
R2340 T3774 T3778 compound 129Ola,backgrounds
R2341 T3775 T3774 punct /,129Ola
R2342 T3776 T3774 compound 6J,129Ola
R2343 T3777 T3774 punct /,129Ola
R2344 T3778 T3772 pobj backgrounds,in
R2345 T3779 T3780 punct (,data
R2346 T3780 T3741 meta data,led
R2347 T3781 T3780 amod unpublished,data
R2348 T3782 T3780 punct ),data
R2349 T3783 T3741 punct .,led
R2350 T3785 T3786 advmod Hence,focused
R2351 T3787 T3786 punct ", ",focused
R2352 T3788 T3786 nsubj we,focused
R2353 T3789 T3790 poss our,analysis
R2354 T3790 T3786 dobj analysis,focused
R2355 T3791 T3786 prep on,focused
R2356 T3792 T3793 det the,line
R2357 T3793 T3791 pobj line,on
R2358 T3794 T3793 amod inbred,line
R2359 T3795 T3793 nmod RanBP2,line
R2360 T3796 T3795 punct +,RanBP2
R2361 T3797 T3795 punct /,RanBP2
R2362 T3798 T3795 punct −,RanBP2
R2363 T3799 T3793 compound 129Ola,line
R2364 T3800 T3793 compound mouse,line
R2365 T3801 T3786 punct .,focused
R2366 T3803 T3804 mark Although,decreased
R2367 T3804 T3810 advcl decreased,remained
R2368 T3805 T3806 det the,levels
R2369 T3806 T3804 nsubjpass levels,decreased
R2370 T3807 T3806 prep of,levels
R2371 T3808 T3807 pobj RanBP2,of
R2372 T3809 T3804 auxpass were,decreased
R2373 T3811 T3804 prep in,decreased
R2374 T3812 T3813 det the,retina
R2375 T3813 T3811 pobj retina,in
R2376 T3814 T3813 punct ", ",retina
R2377 T3815 T3813 conj brain,retina
R2378 T3816 T3815 punct ", ",brain
R2379 T3817 T3815 cc and,brain
R2380 T3818 T3815 conj hippocampus,brain
R2381 T3819 T3813 prep of,retina
R2382 T3820 T3821 nmod RanBP2,mice
R2383 T3821 T3819 pobj mice,of
R2384 T3822 T3820 punct +,RanBP2
R2385 T3823 T3820 punct /,RanBP2
R2386 T3824 T3820 punct −,RanBP2
R2387 T3825 T3804 prep by,decreased
R2388 T3826 T3827 punct ~,50
R2389 T3827 T3828 nummod 50,%
R2390 T3828 T3825 pobj %,by
R2391 T3829 T3830 punct –,%
R2392 T3830 T3828 prep %,%
R2393 T3831 T3830 nummod 60,%
R2394 T3832 T3833 punct (,5B
R2395 T3833 T3804 parataxis 5B,decreased
R2396 T3834 T3833 compound Figure,5B
R2397 T3835 T3833 cc and,5B
R2398 T3836 T3833 conj 5C,5B
R2399 T3837 T3833 punct ),5B
R2400 T3838 T3810 punct ", ",remained
R2401 T3839 T3840 det the,levels
R2402 T3840 T3810 nsubj levels,remained
R2403 T3841 T3840 prep of,levels
R2404 T3842 T3843 compound others,nucleoporins
R2405 T3843 T3841 pobj nucleoporins,of
R2406 T3844 T3843 punct ", ",nucleoporins
R2407 T3845 T3843 appos Nup153,nucleoporins
R2408 T3846 T3845 cc and,Nup153
R2409 T3847 T3845 conj Nup62,Nup153
R2410 T3848 T3843 punct ", ",nucleoporins
R2411 T3849 T3843 cc and,nucleoporins
R2412 T3850 T3843 conj mHsp70,nucleoporins
R2413 T3851 T3850 cc and,mHsp70
R2414 T3852 T3850 conj Cox11,mHsp70
R2415 T3853 T3810 punct ", ",remained
R2416 T3854 T3810 acomp unchanged,remained
R2417 T3855 T3856 punct (,data
R2418 T3856 T3810 parataxis data,remained
R2419 T3857 T3858 compound Figure,5B
R2420 T3858 T3856 dep 5B,data
R2421 T3859 T3856 punct ", ",data
R2422 T3860 T3856 amod unpublished,data
R2423 T3861 T3856 punct ),data
R2424 T3862 T3810 punct .,remained
R2425 T3864 T3865 prep In,observed
R2426 T3866 T3864 pobj addition,In
R2427 T3867 T3865 punct ", ",observed
R2428 T3868 T3865 nsubj we,observed
R2429 T3869 T3870 det a,decrease
R2430 T3870 T3865 dobj decrease,observed
R2431 T3871 T3870 amod strong,decrease
R2432 T3872 T3870 prep of,decrease
R2433 T3873 T3874 det the,levels
R2434 T3874 T3872 pobj levels,of
R2435 T3875 T3874 prep of,levels
R2436 T3876 T3875 pobj HKI,of
R2437 T3877 T3870 punct (,decrease
R2438 T3878 T3870 appos 3,decrease
R2439 T3879 T3878 punct -,3
R2440 T3880 T3878 quantmod to,3
R2441 T3881 T3878 advmod 4-fold,3
R2442 T3882 T3865 punct ),observed
R2443 T3883 T3884 punct (,5B
R2444 T3884 T3865 parataxis 5B,observed
R2445 T3885 T3884 compound Figure,5B
R2446 T3886 T3884 cc and,5B
R2447 T3887 T3884 conj 5C,5B
R2448 T3888 T3884 punct ),5B
R2449 T3889 T3865 punct .,observed
R2450 T3891 T3892 det This,decrease
R2451 T3892 T3893 nsubj decrease,was
R2452 T3894 T3893 acomp selective,was
R2453 T3895 T3894 prep to,selective
R2454 T3896 T3897 det the,CNS
R2455 T3897 T3895 pobj CNS,to
R2456 T3898 T3893 punct ", ",was
R2457 T3899 T3900 mark since,remained
R2458 T3900 T3893 advcl remained,was
R2459 T3901 T3902 compound HKI,levels
R2460 T3902 T3900 nsubj levels,remained
R2461 T3903 T3904 advmod largely,unaffected
R2462 T3904 T3900 acomp unaffected,remained
R2463 T3905 T3900 prep in,remained
R2464 T3906 T3907 det the,muscle
R2465 T3907 T3905 pobj muscle,in
R2466 T3908 T3907 amod skeletal,muscle
R2467 T3909 T3907 punct ", ",muscle
R2468 T3910 T3907 conj spleen,muscle
R2469 T3911 T3910 punct ", ",spleen
R2470 T3912 T3910 cc and,spleen
R2471 T3913 T3910 conj liver,spleen
R2472 T3914 T3915 punct (,5D
R2473 T3915 T3893 parataxis 5D,was
R2474 T3916 T3915 compound Figure,5D
R2475 T3917 T3915 punct ),5D
R2476 T3918 T3893 punct .,was
R2477 T3920 T3921 mark Because,plays
R2478 T3921 T3923 advcl plays,probed
R2479 T3922 T3921 nsubj HKI,plays
R2480 T3924 T3925 det a,role
R2481 T3925 T3921 dobj role,plays
R2482 T3926 T3925 amod key,role
R2483 T3927 T3921 prep in,plays
R2484 T3928 T3929 det the,production
R2485 T3929 T3927 pobj production,in
R2486 T3930 T3929 prep of,production
R2487 T3931 T3932 nmod energy,substrates
R2488 T3932 T3930 pobj substrates,of
R2489 T3933 T3932 amod intermediate,substrates
R2490 T3934 T3921 cc and,plays
R2491 T3935 T3936 nsubj HKI,is
R2492 T3936 T3921 conj is,plays
R2493 T3937 T3938 advmod virtually,isoform
R2494 T3938 T3936 attr isoform,is
R2495 T3939 T3938 det the,isoform
R2496 T3940 T3938 amod sole,isoform
R2497 T3941 T3938 compound HK,isoform
R2498 T3942 T3938 acl expressed,isoform
R2499 T3943 T3942 prep in,expressed
R2500 T3944 T3945 det the,CNS
R2501 T3945 T3943 pobj CNS,in
R2502 T3946 T3947 punct [,34
R2503 T3947 T3936 parataxis 34,is
R2504 T3948 T3947 nummod 33,34
R2505 T3949 T3947 punct ",",34
R2506 T3950 T3947 punct ],34
R2507 T3951 T3923 punct ", ",probed
R2508 T3952 T3923 nsubj we,probed
R2509 T3953 T3954 det the,impact
R2510 T3954 T3923 dobj impact,probed
R2511 T3955 T3954 prep of,impact
R2512 T3956 T3957 nmod HKI,reduction
R2513 T3957 T3955 pobj reduction,of
R2514 T3958 T3956 cc and,HKI
R2515 T3959 T3956 conj RanBP2,HKI
R2516 T3960 T3954 prep in,impact
R2517 T3961 T3962 det the,levels
R2518 T3962 T3960 pobj levels,in
R2519 T3963 T3962 prep of,levels
R2520 T3964 T3963 pobj ATP,of
R2521 T3965 T3923 punct .,probed
R2522 T3967 T3968 mark As,shown
R2523 T3968 T3969 advcl shown,was
R2524 T3970 T3968 prep in,shown
R2525 T3971 T3972 compound Figure,5E
R2526 T3972 T3970 pobj 5E,in
R2527 T3973 T3969 punct ", ",was
R2528 T3974 T3969 expl there,was
R2529 T3975 T3976 amod significant,reduction
R2530 T3976 T3969 attr reduction,was
R2531 T3977 T3975 cc and,significant
R2532 T3978 T3975 conj concordant,significant
R2533 T3979 T3976 prep in,reduction
R2534 T3980 T3979 pobj levels,in
R2535 T3981 T3980 prep of,levels
R2536 T3982 T3981 pobj ATP,of
R2537 T3983 T3980 prep in,levels
R2538 T3984 T3985 det the,CNS
R2539 T3985 T3983 pobj CNS,in
R2540 T3986 T3985 punct (,CNS
R2541 T3987 T3985 appos brain,CNS
R2542 T3988 T3987 cc and,brain
R2543 T3989 T3987 conj retina,brain
R2544 T3990 T3983 punct ),in
R2545 T3991 T3983 punct ", ",in
R2546 T3992 T3983 cc but,in
R2547 T3993 T3992 neg not,but
R2548 T3994 T3983 conj in,in
R2549 T3995 T3996 amod non-neuronal,tissues
R2550 T3996 T3994 pobj tissues,in
R2551 T3997 T3969 punct .,was
R2552 T3999 T4000 advmod Finally,observed
R2553 T4001 T4000 punct ", ",observed
R2554 T4002 T4000 nsubj we,observed
R2555 T4003 T4000 advmod also,observed
R2556 T4004 T4005 amod partial,delocalization
R2557 T4005 T4000 dobj delocalization,observed
R2558 T4006 T4004 cc and,partial
R2559 T4007 T4004 conj selective,partial
R2560 T4008 T4005 prep of,delocalization
R2561 T4009 T4008 pobj HKI,of
R2562 T4010 T4008 punct ", ",of
R2563 T4011 T4008 cc but,of
R2564 T4012 T4011 neg not,but
R2565 T4013 T4008 conj of,of
R2566 T4014 T4013 pobj Cox11,of
R2567 T4015 T4005 punct ", ",delocalization
R2568 T4016 T4005 prep from,delocalization
R2569 T4017 T4018 det the,ellipsoid
R2570 T4018 T4016 pobj ellipsoid,from
R2571 T4019 T4018 punct (,ellipsoid
R2572 T4020 T4021 npadvmod mitochondria,rich
R2573 T4021 T4018 amod rich,ellipsoid
R2574 T4022 T4021 punct -,rich
R2575 T4023 T4018 punct ),ellipsoid
R2576 T4024 T4016 prep to,from
R2577 T4025 T4026 det the,myoid
R2578 T4026 T4024 pobj myoid,to
R2579 T4027 T4026 amod adjacent,myoid
R2580 T4028 T4029 amod subcellular,compartment
R2581 T4029 T4016 pobj compartment,from
R2582 T4030 T4029 prep of,compartment
R2583 T4031 T4032 nmod rod,neurons
R2584 T4032 T4030 pobj neurons,of
R2585 T4033 T4032 amod photosensory,neurons
R2586 T4034 T4035 punct (,S2A
R2587 T4035 T4005 parataxis S2A,delocalization
R2588 T4036 T4035 compound Figure,S2A
R2589 T4037 T4038 punct –,S2E
R2590 T4038 T4035 prep S2E,S2A
R2591 T4039 T4035 punct ),S2A
R2592 T4040 T4000 punct .,observed
R2593 T4042 T4043 nsubjpass This,accompanied
R2594 T4044 T4043 auxpass was,accompanied
R2595 T4045 T4043 advmod also,accompanied
R2596 T4046 T4043 agent by,accompanied
R2597 T4047 T4048 amod reduced,levels
R2598 T4048 T4046 pobj levels,by
R2599 T4049 T4048 compound HKI,levels
R2600 T4050 T4048 prep in,levels
R2601 T4051 T4052 det the,retina
R2602 T4052 T4050 pobj retina,in
R2603 T4053 T4052 amod inner,retina
R2604 T4054 T4050 punct ", ",in
R2605 T4055 T4056 prep in,in
R2606 T4056 T4050 prep in,in
R2607 T4057 T4055 amod particular,in
R2608 T4058 T4059 det the,layer
R2609 T4059 T4056 pobj layer,in
R2610 T4060 T4059 amod inner,layer
R2611 T4061 T4059 amod plexiform,layer
R2612 T4062 T4059 punct (,layer
R2613 T4063 T4059 amod synaptic,layer
R2614 T4064 T4059 punct ),layer
R2615 T4065 T4066 punct (,S2A
R2616 T4066 T4043 parataxis S2A,accompanied
R2617 T4067 T4066 compound Figure,S2A
R2618 T4068 T4069 punct –,S2E
R2619 T4069 T4066 prep S2E,S2A
R2620 T4070 T4066 punct ),S2A
R2621 T4071 T4043 punct .,accompanied