Id |
Subject |
Object |
Predicate |
Lexical cue |
T11520 |
0-6 |
NN |
denotes |
Effect |
T11521 |
7-9 |
IN |
denotes |
of |
T11522 |
10-15 |
NN |
denotes |
Cox11 |
T11523 |
16-19 |
CC |
denotes |
and |
T11524 |
20-26 |
NN |
denotes |
RanBP2 |
T11525 |
27-29 |
IN |
denotes |
on |
T11526 |
30-33 |
NN |
denotes |
HKI |
T11527 |
34-42 |
NN |
denotes |
Activity |
T11528 |
42-207 |
sentence |
denotes |
(A) Saturation kinetics, rate versus glucose of HKI (0.24 μg) in the absence (solid circles) and presence of Cox11 (open circles, 0.25 nM; solid triangles, 7.5 nM). |
T11529 |
43-44 |
-LRB- |
denotes |
( |
T11530 |
44-45 |
LS |
denotes |
A |
T11532 |
45-46 |
-RRB- |
denotes |
) |
T11533 |
47-57 |
NN |
denotes |
Saturation |
T11531 |
58-66 |
NNS |
denotes |
kinetics |
T11534 |
66-68 |
, |
denotes |
, |
T11535 |
68-72 |
NN |
denotes |
rate |
T11536 |
73-79 |
CC |
denotes |
versus |
T11537 |
80-87 |
NN |
denotes |
glucose |
T11538 |
88-90 |
IN |
denotes |
of |
T11539 |
91-94 |
NN |
denotes |
HKI |
T11540 |
95-96 |
-LRB- |
denotes |
( |
T11542 |
96-100 |
CD |
denotes |
0.24 |
T11541 |
101-103 |
NNS |
denotes |
μg |
T11543 |
103-104 |
-RRB- |
denotes |
) |
T11544 |
105-107 |
IN |
denotes |
in |
T11545 |
108-111 |
DT |
denotes |
the |
T11546 |
112-119 |
NN |
denotes |
absence |
T11547 |
120-121 |
-LRB- |
denotes |
( |
T11549 |
121-126 |
JJ |
denotes |
solid |
T11548 |
127-134 |
NNS |
denotes |
circles |
T11550 |
134-135 |
-RRB- |
denotes |
) |
T11551 |
136-139 |
CC |
denotes |
and |
T11552 |
140-148 |
NN |
denotes |
presence |
T11553 |
149-151 |
IN |
denotes |
of |
T11554 |
152-157 |
NN |
denotes |
Cox11 |
T11555 |
158-159 |
-LRB- |
denotes |
( |
T11557 |
159-163 |
JJ |
denotes |
open |
T11558 |
164-171 |
NNS |
denotes |
circles |
T11560 |
171-173 |
, |
denotes |
, |
T11561 |
173-177 |
CD |
denotes |
0.25 |
T11559 |
178-180 |
NNS |
denotes |
nM |
T11562 |
180-181 |
: |
denotes |
; |
T11563 |
182-187 |
JJ |
denotes |
solid |
T11564 |
188-197 |
NNS |
denotes |
triangles |
T11565 |
197-199 |
, |
denotes |
, |
T11566 |
199-202 |
CD |
denotes |
7.5 |
T11556 |
203-205 |
NNS |
denotes |
nM |
T11567 |
205-206 |
-RRB- |
denotes |
) |
T11568 |
206-207 |
. |
denotes |
. |
T11569 |
207-278 |
sentence |
denotes |
The activity of HKI decreases with increasing concentrations of Cox11. |
T11570 |
208-211 |
DT |
denotes |
The |
T11571 |
212-220 |
NN |
denotes |
activity |
T11573 |
221-223 |
IN |
denotes |
of |
T11574 |
224-227 |
NN |
denotes |
HKI |
T11572 |
228-237 |
VBZ |
denotes |
decreases |
T11575 |
238-242 |
IN |
denotes |
with |
T11576 |
243-253 |
VBG |
denotes |
increasing |
T11577 |
254-268 |
NNS |
denotes |
concentrations |
T11578 |
269-271 |
IN |
denotes |
of |
T11579 |
272-277 |
NN |
denotes |
Cox11 |
T11580 |
277-278 |
. |
denotes |
. |
T11581 |
278-372 |
sentence |
denotes |
No measurable HKI activity was recorded in the presence of 15 nM of Cox11 (unpublished data). |
T11582 |
279-281 |
DT |
denotes |
No |
T11584 |
282-292 |
JJ |
denotes |
measurable |
T11585 |
293-296 |
NN |
denotes |
HKI |
T11583 |
297-305 |
NN |
denotes |
activity |
T11587 |
306-309 |
VBD |
denotes |
was |
T11586 |
310-318 |
VBN |
denotes |
recorded |
T11588 |
319-321 |
IN |
denotes |
in |
T11589 |
322-325 |
DT |
denotes |
the |
T11590 |
326-334 |
NN |
denotes |
presence |
T11591 |
335-337 |
IN |
denotes |
of |
T11592 |
338-340 |
CD |
denotes |
15 |
T11593 |
341-343 |
NNS |
denotes |
nM |
T11594 |
344-346 |
IN |
denotes |
of |
T11595 |
347-352 |
NN |
denotes |
Cox11 |
T11596 |
353-354 |
-LRB- |
denotes |
( |
T11598 |
354-365 |
JJ |
denotes |
unpublished |
T11597 |
366-370 |
NNS |
denotes |
data |
T11599 |
370-371 |
-RRB- |
denotes |
) |
T11600 |
371-372 |
. |
denotes |
. |
T11601 |
372-485 |
sentence |
denotes |
(B) Hanes-Wolf plot of (A) (1/rate versus glucose) in the absence and presence of fixed concentrations of Cox11. |
T11602 |
373-374 |
-LRB- |
denotes |
( |
T11603 |
374-375 |
LS |
denotes |
B |
T11605 |
375-376 |
-RRB- |
denotes |
) |
T11606 |
377-382 |
NNP |
denotes |
Hanes |
T11608 |
382-383 |
HYPH |
denotes |
- |
T11607 |
383-387 |
NNP |
denotes |
Wolf |
T11604 |
388-392 |
NN |
denotes |
plot |
T11609 |
393-395 |
IN |
denotes |
of |
T11610 |
396-397 |
-LRB- |
denotes |
( |
T11611 |
397-398 |
NN |
denotes |
A |
T11612 |
398-399 |
-RRB- |
denotes |
) |
T11613 |
400-401 |
-LRB- |
denotes |
( |
T11614 |
401-402 |
CD |
denotes |
1 |
T11615 |
402-403 |
SYM |
denotes |
/ |
T11616 |
403-407 |
NN |
denotes |
rate |
T11617 |
408-414 |
CC |
denotes |
versus |
T11618 |
415-422 |
NN |
denotes |
glucose |
T11619 |
422-423 |
-RRB- |
denotes |
) |
T11620 |
424-426 |
IN |
denotes |
in |
T11621 |
427-430 |
DT |
denotes |
the |
T11622 |
431-438 |
NN |
denotes |
absence |
T11623 |
439-442 |
CC |
denotes |
and |
T11624 |
443-451 |
NN |
denotes |
presence |
T11625 |
452-454 |
IN |
denotes |
of |
T11626 |
455-460 |
VBN |
denotes |
fixed |
T11627 |
461-475 |
NNS |
denotes |
concentrations |
T11628 |
476-478 |
IN |
denotes |
of |
T11629 |
479-484 |
NN |
denotes |
Cox11 |
T11630 |
484-485 |
. |
denotes |
. |
T11631 |
485-591 |
sentence |
denotes |
Linearity of reciprocal plots also supported the hyperbolic behavior of the reactions (unpublished data). |
T11632 |
486-495 |
NN |
denotes |
Linearity |
T11634 |
496-498 |
IN |
denotes |
of |
T11635 |
499-509 |
JJ |
denotes |
reciprocal |
T11636 |
510-515 |
NNS |
denotes |
plots |
T11637 |
516-520 |
RB |
denotes |
also |
T11633 |
521-530 |
VBD |
denotes |
supported |
T11638 |
531-534 |
DT |
denotes |
the |
T11640 |
535-545 |
JJ |
denotes |
hyperbolic |
T11639 |
546-554 |
NN |
denotes |
behavior |
T11641 |
555-557 |
IN |
denotes |
of |
T11642 |
558-561 |
DT |
denotes |
the |
T11643 |
562-571 |
NNS |
denotes |
reactions |
T11644 |
572-573 |
-LRB- |
denotes |
( |
T11646 |
573-584 |
JJ |
denotes |
unpublished |
T11645 |
585-589 |
NNS |
denotes |
data |
T11647 |
589-590 |
-RRB- |
denotes |
) |
T11648 |
590-591 |
. |
denotes |
. |
T11649 |
591-703 |
sentence |
denotes |
Cox11 behaves as a noncompetitive inhibitor of HKI by reducing the V max of HKI but not its K m toward glucose. |
T11650 |
592-597 |
NN |
denotes |
Cox11 |
T11651 |
598-605 |
VBZ |
denotes |
behaves |
T11652 |
606-608 |
IN |
denotes |
as |
T11653 |
609-610 |
DT |
denotes |
a |
T11655 |
611-625 |
JJ |
denotes |
noncompetitive |
T11654 |
626-635 |
NN |
denotes |
inhibitor |
T11656 |
636-638 |
IN |
denotes |
of |
T11657 |
639-642 |
NN |
denotes |
HKI |
T11658 |
643-645 |
IN |
denotes |
by |
T11659 |
646-654 |
VBG |
denotes |
reducing |
T11660 |
655-658 |
DT |
denotes |
the |
T11661 |
659-664 |
NN |
denotes |
V max |
T11662 |
665-667 |
IN |
denotes |
of |
T11663 |
668-671 |
NN |
denotes |
HKI |
T11664 |
672-675 |
CC |
denotes |
but |
T11665 |
676-679 |
RB |
denotes |
not |
T11666 |
680-683 |
PRP$ |
denotes |
its |
T11667 |
684-687 |
NN |
denotes |
K m |
T11668 |
688-694 |
IN |
denotes |
toward |
T11669 |
695-702 |
NN |
denotes |
glucose |
T11670 |
702-703 |
. |
denotes |
. |
T11671 |
703-824 |
sentence |
denotes |
(C) HKI rate is plotted as a function of LD concentration at saturating glucose and fixed Cox11 (7.5 nM) concentrations. |
T11672 |
704-705 |
-LRB- |
denotes |
( |
T11673 |
705-706 |
LS |
denotes |
C |
T11675 |
706-707 |
-RRB- |
denotes |
) |
T11676 |
708-711 |
NN |
denotes |
HKI |
T11677 |
712-716 |
NN |
denotes |
rate |
T11678 |
717-719 |
VBZ |
denotes |
is |
T11674 |
720-727 |
VBN |
denotes |
plotted |
T11679 |
728-730 |
IN |
denotes |
as |
T11680 |
731-732 |
DT |
denotes |
a |
T11681 |
733-741 |
NN |
denotes |
function |
T11682 |
742-744 |
IN |
denotes |
of |
T11683 |
745-747 |
NN |
denotes |
LD |
T11684 |
748-761 |
NN |
denotes |
concentration |
T11685 |
762-764 |
IN |
denotes |
at |
T11686 |
765-775 |
VBG |
denotes |
saturating |
T11687 |
776-783 |
NN |
denotes |
glucose |
T11689 |
784-787 |
CC |
denotes |
and |
T11690 |
788-793 |
VBN |
denotes |
fixed |
T11691 |
794-799 |
NN |
denotes |
Cox11 |
T11692 |
800-801 |
-LRB- |
denotes |
( |
T11694 |
801-804 |
CD |
denotes |
7.5 |
T11693 |
805-807 |
NNS |
denotes |
nM |
T11695 |
807-808 |
-RRB- |
denotes |
) |
T11688 |
809-823 |
NNS |
denotes |
concentrations |
T11696 |
823-824 |
. |
denotes |
. |
T11697 |
824-929 |
sentence |
denotes |
Note that increasing concentrations of the LD of RanBP2 reverse the inhibition of HKI activity by Cox11. |
T11698 |
825-829 |
VB |
denotes |
Note |
T11699 |
830-834 |
IN |
denotes |
that |
T11701 |
835-845 |
VBG |
denotes |
increasing |
T11702 |
846-860 |
NNS |
denotes |
concentrations |
T11703 |
861-863 |
IN |
denotes |
of |
T11704 |
864-867 |
DT |
denotes |
the |
T11705 |
868-870 |
NN |
denotes |
LD |
T11706 |
871-873 |
IN |
denotes |
of |
T11707 |
874-880 |
NN |
denotes |
RanBP2 |
T11700 |
881-888 |
VBP |
denotes |
reverse |
T11708 |
889-892 |
DT |
denotes |
the |
T11709 |
893-903 |
NN |
denotes |
inhibition |
T11710 |
904-906 |
IN |
denotes |
of |
T11711 |
907-910 |
NN |
denotes |
HKI |
T11712 |
911-919 |
NN |
denotes |
activity |
T11713 |
920-922 |
IN |
denotes |
by |
T11714 |
923-928 |
NN |
denotes |
Cox11 |
T11715 |
928-929 |
. |
denotes |
. |
T11716 |
929-1073 |
sentence |
denotes |
A half-maximal effect of the LD of RanBP2 on HKI activity in the presence of 7.5 nM of Cox11 was observed at a concentration of ~0.05 nM of LD. |
T11717 |
930-931 |
DT |
denotes |
A |
T11719 |
932-936 |
RB |
denotes |
half |
T11721 |
936-937 |
HYPH |
denotes |
- |
T11720 |
937-944 |
JJ |
denotes |
maximal |
T11718 |
945-951 |
NN |
denotes |
effect |
T11723 |
952-954 |
IN |
denotes |
of |
T11724 |
955-958 |
DT |
denotes |
the |
T11725 |
959-961 |
NN |
denotes |
LD |
T11726 |
962-964 |
IN |
denotes |
of |
T11727 |
965-971 |
NN |
denotes |
RanBP2 |
T11728 |
972-974 |
IN |
denotes |
on |
T11729 |
975-978 |
NN |
denotes |
HKI |
T11730 |
979-987 |
NN |
denotes |
activity |
T11731 |
988-990 |
IN |
denotes |
in |
T11732 |
991-994 |
DT |
denotes |
the |
T11733 |
995-1003 |
NN |
denotes |
presence |
T11734 |
1004-1006 |
IN |
denotes |
of |
T11735 |
1007-1010 |
CD |
denotes |
7.5 |
T11736 |
1011-1013 |
NNS |
denotes |
nM |
T11737 |
1014-1016 |
IN |
denotes |
of |
T11738 |
1017-1022 |
NN |
denotes |
Cox11 |
T11739 |
1023-1026 |
VBD |
denotes |
was |
T11722 |
1027-1035 |
VBN |
denotes |
observed |
T11740 |
1036-1038 |
IN |
denotes |
at |
T11741 |
1039-1040 |
DT |
denotes |
a |
T11742 |
1041-1054 |
NN |
denotes |
concentration |
T11743 |
1055-1057 |
IN |
denotes |
of |
T11744 |
1058-1059 |
SYM |
denotes |
~ |
T11745 |
1059-1063 |
CD |
denotes |
0.05 |
T11746 |
1064-1066 |
NNS |
denotes |
nM |
T11747 |
1067-1069 |
IN |
denotes |
of |
T11748 |
1070-1072 |
NN |
denotes |
LD |
T11749 |
1072-1073 |
. |
denotes |
. |
T11750 |
1073-1151 |
sentence |
denotes |
(D) Rate versus glucose plot in the absence and presence of the LD of RanBP2. |
T11751 |
1074-1075 |
-LRB- |
denotes |
( |
T11752 |
1075-1076 |
LS |
denotes |
D |
T11754 |
1076-1077 |
-RRB- |
denotes |
) |
T11755 |
1078-1082 |
NN |
denotes |
Rate |
T11756 |
1083-1089 |
CC |
denotes |
versus |
T11757 |
1090-1097 |
NN |
denotes |
glucose |
T11753 |
1098-1102 |
NN |
denotes |
plot |
T11758 |
1103-1105 |
IN |
denotes |
in |
T11759 |
1106-1109 |
DT |
denotes |
the |
T11760 |
1110-1117 |
NN |
denotes |
absence |
T11761 |
1118-1121 |
CC |
denotes |
and |
T11762 |
1122-1130 |
NN |
denotes |
presence |
T11763 |
1131-1133 |
IN |
denotes |
of |
T11764 |
1134-1137 |
DT |
denotes |
the |
T11765 |
1138-1140 |
NN |
denotes |
LD |
T11766 |
1141-1143 |
IN |
denotes |
of |
T11767 |
1144-1150 |
NN |
denotes |
RanBP2 |
T11768 |
1150-1151 |
. |
denotes |
. |
T11769 |
1151-1255 |
sentence |
denotes |
At a saturating concentration of the LD of RanBP2 (3.75 nM), the HKI activity was reduced by about 20%. |
T11770 |
1152-1154 |
IN |
denotes |
At |
T11772 |
1155-1156 |
DT |
denotes |
a |
T11774 |
1157-1167 |
NN |
denotes |
saturating |
T11773 |
1168-1181 |
NN |
denotes |
concentration |
T11775 |
1182-1184 |
IN |
denotes |
of |
T11776 |
1185-1188 |
DT |
denotes |
the |
T11777 |
1189-1191 |
NN |
denotes |
LD |
T11778 |
1192-1194 |
IN |
denotes |
of |
T11779 |
1195-1201 |
NN |
denotes |
RanBP2 |
T11780 |
1202-1203 |
-LRB- |
denotes |
( |
T11782 |
1203-1207 |
CD |
denotes |
3.75 |
T11781 |
1208-1210 |
NNS |
denotes |
nM |
T11783 |
1210-1211 |
-RRB- |
denotes |
) |
T11784 |
1211-1213 |
, |
denotes |
, |
T11785 |
1213-1216 |
DT |
denotes |
the |
T11787 |
1217-1220 |
NN |
denotes |
HKI |
T11786 |
1221-1229 |
NN |
denotes |
activity |
T11788 |
1230-1233 |
VBD |
denotes |
was |
T11771 |
1234-1241 |
VBN |
denotes |
reduced |
T11789 |
1242-1244 |
IN |
denotes |
by |
T11790 |
1245-1250 |
IN |
denotes |
about |
T11791 |
1251-1253 |
CD |
denotes |
20 |
T11792 |
1253-1254 |
NN |
denotes |
% |
T11793 |
1254-1255 |
. |
denotes |
. |
T11794 |
1255-1276 |
sentence |
denotes |
v, rate; S, glucose. |
T11795 |
1256-1257 |
NN |
denotes |
v |
T11796 |
1257-1259 |
, |
denotes |
, |
T11797 |
1259-1263 |
NN |
denotes |
rate |
T11798 |
1263-1264 |
: |
denotes |
; |
T11799 |
1265-1266 |
NN |
denotes |
S |
T11800 |
1266-1268 |
, |
denotes |
, |
T11801 |
1268-1275 |
NN |
denotes |
glucose |
T11802 |
1275-1276 |
. |
denotes |
. |
R7697 |
T11521 |
T11520 |
prep |
of,Effect |
R7698 |
T11522 |
T11521 |
pobj |
Cox11,of |
R7699 |
T11523 |
T11522 |
cc |
and,Cox11 |
R7700 |
T11524 |
T11522 |
conj |
RanBP2,Cox11 |
R7701 |
T11525 |
T11520 |
prep |
on,Effect |
R7702 |
T11526 |
T11527 |
compound |
HKI,Activity |
R7703 |
T11527 |
T11525 |
pobj |
Activity,on |
R7704 |
T11529 |
T11530 |
punct |
(,A |
R7705 |
T11530 |
T11531 |
meta |
A,kinetics |
R7706 |
T11532 |
T11530 |
punct |
),A |
R7707 |
T11533 |
T11531 |
compound |
Saturation,kinetics |
R7708 |
T11534 |
T11531 |
punct |
", ",kinetics |
R7709 |
T11535 |
T11531 |
npadvmod |
rate,kinetics |
R7710 |
T11536 |
T11535 |
cc |
versus,rate |
R7711 |
T11537 |
T11535 |
conj |
glucose,rate |
R7712 |
T11538 |
T11531 |
prep |
of,kinetics |
R7713 |
T11539 |
T11538 |
pobj |
HKI,of |
R7714 |
T11540 |
T11541 |
punct |
(,μg |
R7715 |
T11541 |
T11539 |
parataxis |
μg,HKI |
R7716 |
T11542 |
T11541 |
nummod |
0.24,μg |
R7717 |
T11543 |
T11541 |
punct |
),μg |
R7718 |
T11544 |
T11531 |
prep |
in,kinetics |
R7719 |
T11545 |
T11546 |
det |
the,absence |
R7720 |
T11546 |
T11544 |
pobj |
absence,in |
R7721 |
T11547 |
T11548 |
punct |
(,circles |
R7722 |
T11548 |
T11546 |
parataxis |
circles,absence |
R7723 |
T11549 |
T11548 |
amod |
solid,circles |
R7724 |
T11550 |
T11548 |
punct |
),circles |
R7725 |
T11551 |
T11546 |
cc |
and,absence |
R7726 |
T11552 |
T11546 |
conj |
presence,absence |
R7727 |
T11553 |
T11546 |
prep |
of,absence |
R7728 |
T11554 |
T11553 |
pobj |
Cox11,of |
R7729 |
T11555 |
T11556 |
punct |
(,nM |
R7730 |
T11556 |
T11531 |
parataxis |
nM,kinetics |
R7731 |
T11557 |
T11558 |
amod |
open,circles |
R7732 |
T11558 |
T11559 |
dep |
circles,nM |
R7733 |
T11559 |
T11556 |
dep |
nM,nM |
R7734 |
T11560 |
T11559 |
punct |
", ",nM |
R7735 |
T11561 |
T11559 |
nummod |
0.25,nM |
R7736 |
T11562 |
T11556 |
punct |
;,nM |
R7737 |
T11563 |
T11564 |
amod |
solid,triangles |
R7738 |
T11564 |
T11556 |
dep |
triangles,nM |
R7739 |
T11565 |
T11556 |
punct |
", ",nM |
R7740 |
T11566 |
T11556 |
nummod |
7.5,nM |
R7741 |
T11567 |
T11556 |
punct |
),nM |
R7742 |
T11568 |
T11531 |
punct |
.,kinetics |
R7743 |
T11570 |
T11571 |
det |
The,activity |
R7744 |
T11571 |
T11572 |
nsubj |
activity,decreases |
R7745 |
T11573 |
T11571 |
prep |
of,activity |
R7746 |
T11574 |
T11573 |
pobj |
HKI,of |
R7747 |
T11575 |
T11572 |
prep |
with,decreases |
R7748 |
T11576 |
T11577 |
amod |
increasing,concentrations |
R7749 |
T11577 |
T11575 |
pobj |
concentrations,with |
R7750 |
T11578 |
T11577 |
prep |
of,concentrations |
R7751 |
T11579 |
T11578 |
pobj |
Cox11,of |
R7752 |
T11580 |
T11572 |
punct |
.,decreases |
R7753 |
T11582 |
T11583 |
det |
No,activity |
R7754 |
T11583 |
T11586 |
nsubjpass |
activity,recorded |
R7755 |
T11584 |
T11583 |
amod |
measurable,activity |
R7756 |
T11585 |
T11583 |
compound |
HKI,activity |
R7757 |
T11587 |
T11586 |
auxpass |
was,recorded |
R7758 |
T11588 |
T11586 |
prep |
in,recorded |
R7759 |
T11589 |
T11590 |
det |
the,presence |
R7760 |
T11590 |
T11588 |
pobj |
presence,in |
R7761 |
T11591 |
T11590 |
prep |
of,presence |
R7762 |
T11592 |
T11593 |
nummod |
15,nM |
R7763 |
T11593 |
T11591 |
pobj |
nM,of |
R7764 |
T11594 |
T11593 |
prep |
of,nM |
R7765 |
T11595 |
T11594 |
pobj |
Cox11,of |
R7766 |
T11596 |
T11597 |
punct |
(,data |
R7767 |
T11597 |
T11586 |
meta |
data,recorded |
R7768 |
T11598 |
T11597 |
amod |
unpublished,data |
R7769 |
T11599 |
T11597 |
punct |
),data |
R7770 |
T11600 |
T11586 |
punct |
.,recorded |
R7771 |
T11602 |
T11603 |
punct |
(,B |
R7772 |
T11603 |
T11604 |
meta |
B,plot |
R7773 |
T11605 |
T11603 |
punct |
),B |
R7774 |
T11606 |
T11607 |
compound |
Hanes,Wolf |
R7775 |
T11607 |
T11604 |
compound |
Wolf,plot |
R7776 |
T11608 |
T11607 |
punct |
-,Wolf |
R7777 |
T11609 |
T11604 |
prep |
of,plot |
R7778 |
T11610 |
T11611 |
punct |
(,A |
R7779 |
T11611 |
T11609 |
parataxis |
A,of |
R7780 |
T11612 |
T11611 |
punct |
),A |
R7781 |
T11613 |
T11609 |
punct |
(,of |
R7782 |
T11614 |
T11609 |
pobj |
1,of |
R7783 |
T11615 |
T11616 |
punct |
/,rate |
R7784 |
T11616 |
T11614 |
prep |
rate,1 |
R7785 |
T11617 |
T11614 |
cc |
versus,1 |
R7786 |
T11618 |
T11614 |
conj |
glucose,1 |
R7787 |
T11619 |
T11604 |
punct |
),plot |
R7788 |
T11620 |
T11604 |
prep |
in,plot |
R7789 |
T11621 |
T11622 |
det |
the,absence |
R7790 |
T11622 |
T11620 |
pobj |
absence,in |
R7791 |
T11623 |
T11622 |
cc |
and,absence |
R7792 |
T11624 |
T11622 |
conj |
presence,absence |
R7793 |
T11625 |
T11622 |
prep |
of,absence |
R7794 |
T11626 |
T11627 |
amod |
fixed,concentrations |
R7795 |
T11627 |
T11625 |
pobj |
concentrations,of |
R7796 |
T11628 |
T11627 |
prep |
of,concentrations |
R7797 |
T11629 |
T11628 |
pobj |
Cox11,of |
R7798 |
T11630 |
T11604 |
punct |
.,plot |
R7799 |
T11632 |
T11633 |
nsubj |
Linearity,supported |
R7800 |
T11634 |
T11632 |
prep |
of,Linearity |
R7801 |
T11635 |
T11636 |
amod |
reciprocal,plots |
R7802 |
T11636 |
T11634 |
pobj |
plots,of |
R7803 |
T11637 |
T11633 |
advmod |
also,supported |
R7804 |
T11638 |
T11639 |
det |
the,behavior |
R7805 |
T11639 |
T11633 |
dobj |
behavior,supported |
R7806 |
T11640 |
T11639 |
amod |
hyperbolic,behavior |
R7807 |
T11641 |
T11639 |
prep |
of,behavior |
R7808 |
T11642 |
T11643 |
det |
the,reactions |
R7809 |
T11643 |
T11641 |
pobj |
reactions,of |
R7810 |
T11644 |
T11645 |
punct |
(,data |
R7811 |
T11645 |
T11633 |
meta |
data,supported |
R7812 |
T11646 |
T11645 |
amod |
unpublished,data |
R7813 |
T11647 |
T11645 |
punct |
),data |
R7814 |
T11648 |
T11633 |
punct |
.,supported |
R7815 |
T11650 |
T11651 |
nsubj |
Cox11,behaves |
R7816 |
T11652 |
T11651 |
prep |
as,behaves |
R7817 |
T11653 |
T11654 |
det |
a,inhibitor |
R7818 |
T11654 |
T11652 |
pobj |
inhibitor,as |
R7819 |
T11655 |
T11654 |
amod |
noncompetitive,inhibitor |
R7820 |
T11656 |
T11654 |
prep |
of,inhibitor |
R7821 |
T11657 |
T11656 |
pobj |
HKI,of |
R7822 |
T11658 |
T11651 |
prep |
by,behaves |
R7823 |
T11659 |
T11658 |
pcomp |
reducing,by |
R7824 |
T11660 |
T11661 |
det |
the,V max |
R7825 |
T11661 |
T11659 |
dobj |
V max,reducing |
R7826 |
T11662 |
T11661 |
prep |
of,V max |
R7827 |
T11663 |
T11662 |
pobj |
HKI,of |
R7828 |
T11664 |
T11661 |
cc |
but,V max |
R7829 |
T11665 |
T11664 |
neg |
not,but |
R7830 |
T11666 |
T11667 |
poss |
its,K m |
R7831 |
T11667 |
T11661 |
conj |
K m,V max |
R7832 |
T11668 |
T11667 |
prep |
toward,K m |
R7833 |
T11669 |
T11668 |
pobj |
glucose,toward |
R7834 |
T11670 |
T11651 |
punct |
.,behaves |
R7835 |
T11672 |
T11673 |
punct |
(,C |
R7836 |
T11673 |
T11674 |
meta |
C,plotted |
R7837 |
T11675 |
T11673 |
punct |
),C |
R7838 |
T11676 |
T11677 |
compound |
HKI,rate |
R7839 |
T11677 |
T11674 |
nsubjpass |
rate,plotted |
R7840 |
T11678 |
T11674 |
auxpass |
is,plotted |
R7841 |
T11679 |
T11674 |
prep |
as,plotted |
R7842 |
T11680 |
T11681 |
det |
a,function |
R7843 |
T11681 |
T11679 |
pobj |
function,as |
R7844 |
T11682 |
T11681 |
prep |
of,function |
R7845 |
T11683 |
T11684 |
compound |
LD,concentration |
R7846 |
T11684 |
T11682 |
pobj |
concentration,of |
R7847 |
T11685 |
T11674 |
prep |
at,plotted |
R7848 |
T11686 |
T11687 |
amod |
saturating,glucose |
R7849 |
T11687 |
T11688 |
nmod |
glucose,concentrations |
R7850 |
T11688 |
T11685 |
pobj |
concentrations,at |
R7851 |
T11689 |
T11687 |
cc |
and,glucose |
R7852 |
T11690 |
T11691 |
amod |
fixed,Cox11 |
R7853 |
T11691 |
T11687 |
conj |
Cox11,glucose |
R7854 |
T11692 |
T11693 |
punct |
(,nM |
R7855 |
T11693 |
T11691 |
parataxis |
nM,Cox11 |
R7856 |
T11694 |
T11693 |
nummod |
7.5,nM |
R7857 |
T11695 |
T11693 |
punct |
),nM |
R7858 |
T11696 |
T11674 |
punct |
.,plotted |
R7859 |
T11699 |
T11700 |
mark |
that,reverse |
R7860 |
T11700 |
T11698 |
ccomp |
reverse,Note |
R7861 |
T11701 |
T11702 |
amod |
increasing,concentrations |
R7862 |
T11702 |
T11700 |
nsubj |
concentrations,reverse |
R7863 |
T11703 |
T11702 |
prep |
of,concentrations |
R7864 |
T11704 |
T11705 |
det |
the,LD |
R7865 |
T11705 |
T11703 |
pobj |
LD,of |
R7866 |
T11706 |
T11705 |
prep |
of,LD |
R7867 |
T11707 |
T11706 |
pobj |
RanBP2,of |
R7868 |
T11708 |
T11709 |
det |
the,inhibition |
R7869 |
T11709 |
T11700 |
dobj |
inhibition,reverse |
R7870 |
T11710 |
T11709 |
prep |
of,inhibition |
R7871 |
T11711 |
T11712 |
compound |
HKI,activity |
R7872 |
T11712 |
T11710 |
pobj |
activity,of |
R7873 |
T11713 |
T11709 |
prep |
by,inhibition |
R7874 |
T11714 |
T11713 |
pobj |
Cox11,by |
R7875 |
T11715 |
T11698 |
punct |
.,Note |
R7876 |
T11717 |
T11718 |
det |
A,effect |
R7877 |
T11718 |
T11722 |
nsubjpass |
effect,observed |
R7878 |
T11719 |
T11720 |
advmod |
half,maximal |
R7879 |
T11720 |
T11718 |
amod |
maximal,effect |
R7880 |
T11721 |
T11720 |
punct |
-,maximal |
R7881 |
T11723 |
T11718 |
prep |
of,effect |
R7882 |
T11724 |
T11725 |
det |
the,LD |
R7883 |
T11725 |
T11723 |
pobj |
LD,of |
R7884 |
T11726 |
T11725 |
prep |
of,LD |
R7885 |
T11727 |
T11726 |
pobj |
RanBP2,of |
R7886 |
T11728 |
T11718 |
prep |
on,effect |
R7887 |
T11729 |
T11730 |
compound |
HKI,activity |
R7888 |
T11730 |
T11728 |
pobj |
activity,on |
R7889 |
T11731 |
T11718 |
prep |
in,effect |
R7890 |
T11732 |
T11733 |
det |
the,presence |
R7891 |
T11733 |
T11731 |
pobj |
presence,in |
R7892 |
T11734 |
T11733 |
prep |
of,presence |
R7893 |
T11735 |
T11736 |
nummod |
7.5,nM |
R7894 |
T11736 |
T11734 |
pobj |
nM,of |
R7895 |
T11737 |
T11736 |
prep |
of,nM |
R7896 |
T11738 |
T11737 |
pobj |
Cox11,of |
R7897 |
T11739 |
T11722 |
auxpass |
was,observed |
R7898 |
T11740 |
T11722 |
prep |
at,observed |
R7899 |
T11741 |
T11742 |
det |
a,concentration |
R7900 |
T11742 |
T11740 |
pobj |
concentration,at |
R7901 |
T11743 |
T11742 |
prep |
of,concentration |
R7902 |
T11744 |
T11745 |
punct |
~,0.05 |
R7903 |
T11745 |
T11746 |
nummod |
0.05,nM |
R7904 |
T11746 |
T11743 |
pobj |
nM,of |
R7905 |
T11747 |
T11746 |
prep |
of,nM |
R7906 |
T11748 |
T11747 |
pobj |
LD,of |
R7907 |
T11749 |
T11722 |
punct |
.,observed |
R7908 |
T11751 |
T11752 |
punct |
(,D |
R7909 |
T11752 |
T11753 |
meta |
D,plot |
R7910 |
T11754 |
T11752 |
punct |
),D |
R7911 |
T11755 |
T11753 |
nmod |
Rate,plot |
R7912 |
T11756 |
T11755 |
cc |
versus,Rate |
R7913 |
T11757 |
T11755 |
conj |
glucose,Rate |
R7914 |
T11758 |
T11753 |
prep |
in,plot |
R7915 |
T11759 |
T11760 |
det |
the,absence |
R7916 |
T11760 |
T11758 |
pobj |
absence,in |
R7917 |
T11761 |
T11760 |
cc |
and,absence |
R7918 |
T11762 |
T11760 |
conj |
presence,absence |
R7919 |
T11763 |
T11760 |
prep |
of,absence |
R7920 |
T11764 |
T11765 |
det |
the,LD |
R7921 |
T11765 |
T11763 |
pobj |
LD,of |
R7922 |
T11766 |
T11765 |
prep |
of,LD |
R7923 |
T11767 |
T11766 |
pobj |
RanBP2,of |
R7924 |
T11768 |
T11753 |
punct |
.,plot |
R7925 |
T11770 |
T11771 |
prep |
At,reduced |
R7926 |
T11772 |
T11773 |
det |
a,concentration |
R7927 |
T11773 |
T11770 |
pobj |
concentration,At |
R7928 |
T11774 |
T11773 |
compound |
saturating,concentration |
R7929 |
T11775 |
T11773 |
prep |
of,concentration |
R7930 |
T11776 |
T11777 |
det |
the,LD |
R7931 |
T11777 |
T11775 |
pobj |
LD,of |
R7932 |
T11778 |
T11777 |
prep |
of,LD |
R7933 |
T11779 |
T11778 |
pobj |
RanBP2,of |
R7934 |
T11780 |
T11781 |
punct |
(,nM |
R7935 |
T11781 |
T11773 |
parataxis |
nM,concentration |
R7936 |
T11782 |
T11781 |
nummod |
3.75,nM |
R7937 |
T11783 |
T11781 |
punct |
),nM |
R7938 |
T11784 |
T11771 |
punct |
", ",reduced |
R7939 |
T11785 |
T11786 |
det |
the,activity |
R7940 |
T11786 |
T11771 |
nsubjpass |
activity,reduced |
R7941 |
T11787 |
T11786 |
compound |
HKI,activity |
R7942 |
T11788 |
T11771 |
auxpass |
was,reduced |
R7943 |
T11789 |
T11771 |
prep |
by,reduced |
R7944 |
T11790 |
T11791 |
quantmod |
about,20 |
R7945 |
T11791 |
T11792 |
nummod |
20,% |
R7946 |
T11792 |
T11789 |
pobj |
%,by |
R7947 |
T11793 |
T11771 |
punct |
.,reduced |
R7948 |
T11796 |
T11795 |
punct |
", ",v |
R7949 |
T11797 |
T11795 |
appos |
rate,v |
R7950 |
T11798 |
T11795 |
punct |
;,v |
R7951 |
T11799 |
T11795 |
appos |
S,v |
R7952 |
T11800 |
T11799 |
punct |
", ",S |
R7953 |
T11801 |
T11799 |
appos |
glucose,S |
R7954 |
T11802 |
T11795 |
punct |
.,v |