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PMC:1617083 / 2571-37851 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T3130 11-17 NN denotes Family
T3131 18-25 NN denotes history
T3133 26-27 -LRB- denotes [
T3134 27-28 CD denotes 1
T3135 28-29 -RRB- denotes ]
T3132 30-32 VBZ denotes is
T3136 33-36 DT denotes the
T3138 37-46 JJS denotes strongest
T3139 47-51 NN denotes risk
T3137 52-58 NN denotes factor
T3140 59-62 IN denotes for
T3141 63-77 JJ denotes cardiovascular
T3142 78-86 NNS denotes diseases
T3143 87-88 -LRB- denotes (
T3144 88-91 NNS denotes CVD
T3145 91-92 -RRB- denotes )
T3146 92-93 . denotes .
T3147 93-226 sentence denotes While a number of genetic mutations have been identified, these account for only a small percentage of the CVD in human populations.
T3148 94-99 IN denotes While
T3150 100-101 DT denotes a
T3151 102-108 NN denotes number
T3152 109-111 IN denotes of
T3153 112-119 JJ denotes genetic
T3154 120-129 NNS denotes mutations
T3155 130-134 VBP denotes have
T3156 135-139 VBN denotes been
T3149 140-150 VBN denotes identified
T3158 150-152 , denotes ,
T3159 152-157 DT denotes these
T3157 158-165 VBP denotes account
T3160 166-169 IN denotes for
T3161 170-174 RB denotes only
T3163 175-176 DT denotes a
T3164 177-182 JJ denotes small
T3162 183-193 NN denotes percentage
T3165 194-196 IN denotes of
T3166 197-200 DT denotes the
T3167 201-204 NNS denotes CVD
T3168 205-207 IN denotes in
T3169 208-213 JJ denotes human
T3170 214-225 NNS denotes populations
T3171 225-226 . denotes .
T3172 226-471 sentence denotes Thrombus formation on fissured atherosclerotic plaques is the precipitating event in the transition from a stable or subclinical atherosclerotic disease and leads to acute myocardial infarction, ischemic stroke or peripheral arterial occlusion.
T3173 227-235 NN denotes Thrombus
T3174 236-245 NN denotes formation
T3176 246-248 IN denotes on
T3177 249-257 VBN denotes fissured
T3179 258-273 JJ denotes atherosclerotic
T3178 274-281 NNS denotes plaques
T3175 282-284 VBZ denotes is
T3180 285-288 DT denotes the
T3182 289-302 VBG denotes precipitating
T3181 303-308 NN denotes event
T3183 309-311 IN denotes in
T3184 312-315 DT denotes the
T3185 316-326 NN denotes transition
T3186 327-331 IN denotes from
T3187 332-333 DT denotes a
T3189 334-340 JJ denotes stable
T3190 341-343 CC denotes or
T3191 344-355 JJ denotes subclinical
T3192 356-371 JJ denotes atherosclerotic
T3188 372-379 NN denotes disease
T3193 380-383 CC denotes and
T3194 384-389 VBZ denotes leads
T3195 390-392 IN denotes to
T3196 393-398 JJ denotes acute
T3198 399-409 JJ denotes myocardial
T3197 410-420 NN denotes infarction
T3199 420-422 , denotes ,
T3200 422-430 JJ denotes ischemic
T3201 431-437 NN denotes stroke
T3202 438-440 CC denotes or
T3203 441-451 JJ denotes peripheral
T3204 452-460 JJ denotes arterial
T3205 461-470 NN denotes occlusion
T3206 470-471 . denotes .
T3207 471-596 sentence denotes Arterial and venous thrombosis are complex responses and are influenced by multiple genetic and environmental factors [2-5].
T3208 472-480 JJ denotes Arterial
T3210 481-484 CC denotes and
T3211 485-491 JJ denotes venous
T3209 492-502 NN denotes thrombosis
T3212 503-506 VBP denotes are
T3213 507-514 JJ denotes complex
T3214 515-524 NNS denotes responses
T3215 525-528 CC denotes and
T3216 529-532 VBP denotes are
T3217 533-543 VBN denotes influenced
T3218 544-546 IN denotes by
T3219 547-555 JJ denotes multiple
T3221 556-563 JJ denotes genetic
T3222 564-567 CC denotes and
T3223 568-581 JJ denotes environmental
T3220 582-589 NNS denotes factors
T3224 590-591 -LRB- denotes [
T3225 591-592 CD denotes 2
T3226 592-593 SYM denotes -
T3227 593-594 CD denotes 5
T3228 594-595 -RRB- denotes ]
T3229 595-596 . denotes .
T3230 596-878 sentence denotes Polymorphisms and mutations in coagulation factors, fibrinolytic factors, platelet surface receptors, methylenetetrahydrofalate reductase, endothelial nitric oxide synthase, and antioxidant enzymes have been implicated as genetic determinants of susceptibility to thrombosis [6,7].
T3231 597-610 NNS denotes Polymorphisms
T3233 611-614 CC denotes and
T3234 615-624 NNS denotes mutations
T3235 625-627 IN denotes in
T3236 628-639 NN denotes coagulation
T3237 640-647 NNS denotes factors
T3238 647-649 , denotes ,
T3239 649-661 JJ denotes fibrinolytic
T3240 662-669 NNS denotes factors
T3241 669-671 , denotes ,
T3242 671-679 NN denotes platelet
T3243 680-687 NN denotes surface
T3244 688-697 NNS denotes receptors
T3245 697-699 , denotes ,
T3246 699-724 NN denotes methylenetetrahydrofalate
T3247 725-734 NN denotes reductase
T3248 734-736 , denotes ,
T3249 736-747 JJ denotes endothelial
T3251 748-754 JJ denotes nitric
T3252 755-760 NN denotes oxide
T3250 761-769 NN denotes synthase
T3253 769-771 , denotes ,
T3254 771-774 CC denotes and
T3255 775-786 JJ denotes antioxidant
T3256 787-794 NNS denotes enzymes
T3257 795-799 VBP denotes have
T3258 800-804 VBN denotes been
T3232 805-815 VBN denotes implicated
T3259 816-818 IN denotes as
T3260 819-826 JJ denotes genetic
T3261 827-839 NNS denotes determinants
T3262 840-842 IN denotes of
T3263 843-857 NN denotes susceptibility
T3264 858-860 IN denotes to
T3265 861-871 NN denotes thrombosis
T3266 872-873 -LRB- denotes [
T3268 873-874 CD denotes 6
T3269 874-875 , denotes ,
T3267 875-876 CD denotes 7
T3270 876-877 -RRB- denotes ]
T3271 877-878 . denotes .
T3272 878-972 sentence denotes Great strides have been made in the diagnosis and treatment of thrombosis in the last decade.
T3273 879-884 JJ denotes Great
T3274 885-892 NNS denotes strides
T3276 893-897 VBP denotes have
T3277 898-902 VBN denotes been
T3275 903-907 VBN denotes made
T3278 908-910 IN denotes in
T3279 911-914 DT denotes the
T3280 915-924 NN denotes diagnosis
T3281 925-928 CC denotes and
T3282 929-938 NN denotes treatment
T3283 939-941 IN denotes of
T3284 942-952 NN denotes thrombosis
T3285 953-955 IN denotes in
T3286 956-959 DT denotes the
T3288 960-964 JJ denotes last
T3287 965-971 NN denotes decade
T3289 971-972 . denotes .
T3290 972-1152 sentence denotes However, strategies to prevent thrombosis have lagged far behind due, in part, to the contribution of multiple, and as yet undefined, genetic factors that lead to thrombotic risk.
T3291 973-980 RB denotes However
T3293 980-982 , denotes ,
T3294 982-992 NNS denotes strategies
T3295 993-995 TO denotes to
T3296 996-1003 VB denotes prevent
T3297 1004-1014 NN denotes thrombosis
T3298 1015-1019 VBP denotes have
T3292 1020-1026 VBN denotes lagged
T3299 1027-1030 RB denotes far
T3300 1031-1037 RB denotes behind
T3301 1038-1041 IN denotes due
T3302 1041-1043 , denotes ,
T3303 1043-1045 IN denotes in
T3304 1046-1050 JJ denotes part
T3305 1050-1052 , denotes ,
T3306 1052-1054 IN denotes to
T3307 1055-1058 DT denotes the
T3308 1059-1071 NN denotes contribution
T3309 1072-1074 IN denotes of
T3310 1075-1083 JJ denotes multiple
T3312 1083-1085 , denotes ,
T3313 1085-1088 CC denotes and
T3314 1089-1091 RB denotes as
T3315 1092-1095 RB denotes yet
T3316 1096-1105 JJ denotes undefined
T3317 1105-1107 , denotes ,
T3318 1107-1114 JJ denotes genetic
T3311 1115-1122 NNS denotes factors
T3319 1123-1127 WDT denotes that
T3320 1128-1132 VBP denotes lead
T3321 1133-1135 IN denotes to
T3322 1136-1146 JJ denotes thrombotic
T3323 1147-1151 NN denotes risk
T3324 1151-1152 . denotes .
T3325 1152-1362 sentence denotes Moreover, it remains unclear how genetic background influences the function of molecules and pathways known to regulate thrombus formation and lysis and, thereby, contributes to the risk of thrombotic disease.
T3326 1153-1161 RB denotes Moreover
T3328 1161-1163 , denotes ,
T3329 1163-1165 PRP denotes it
T3327 1166-1173 VBZ denotes remains
T3330 1174-1181 JJ denotes unclear
T3331 1182-1185 WRB denotes how
T3333 1186-1193 JJ denotes genetic
T3334 1194-1204 NN denotes background
T3332 1205-1215 VBZ denotes influences
T3335 1216-1219 DT denotes the
T3336 1220-1228 NN denotes function
T3337 1229-1231 IN denotes of
T3338 1232-1241 NNS denotes molecules
T3339 1242-1245 CC denotes and
T3340 1246-1254 NNS denotes pathways
T3341 1255-1260 VBN denotes known
T3342 1261-1263 TO denotes to
T3343 1264-1272 VB denotes regulate
T3344 1273-1281 NN denotes thrombus
T3345 1282-1291 NN denotes formation
T3346 1292-1295 CC denotes and
T3347 1296-1301 NN denotes lysis
T3348 1302-1305 CC denotes and
T3349 1305-1307 , denotes ,
T3350 1307-1314 RB denotes thereby
T3352 1314-1316 , denotes ,
T3351 1316-1327 VBZ denotes contributes
T3353 1328-1330 IN denotes to
T3354 1331-1334 DT denotes the
T3355 1335-1339 NN denotes risk
T3356 1340-1342 IN denotes of
T3357 1343-1353 JJ denotes thrombotic
T3358 1354-1361 NN denotes disease
T3359 1361-1362 . denotes .
T3360 1362-1528 sentence denotes Many of the available inbred mouse strains, such as C57BL/6J (B6) and A/J, have been classified as resistant or susceptible to particular complex diseases (Table 1).
T3361 1363-1367 JJ denotes Many
T3363 1368-1370 IN denotes of
T3364 1371-1374 DT denotes the
T3366 1375-1384 JJ denotes available
T3367 1385-1391 JJ denotes inbred
T3368 1392-1397 NN denotes mouse
T3365 1398-1405 NNS denotes strains
T3369 1405-1407 , denotes ,
T3370 1407-1411 JJ denotes such
T3371 1412-1414 IN denotes as
T3372 1415-1420 NN denotes C57BL
T3374 1420-1421 HYPH denotes /
T3373 1421-1423 NN denotes 6J
T3375 1424-1425 -LRB- denotes (
T3376 1425-1427 NN denotes B6
T3377 1427-1428 -RRB- denotes )
T3378 1429-1432 CC denotes and
T3379 1433-1434 NN denotes A
T3381 1434-1435 HYPH denotes /
T3380 1435-1436 NN denotes J
T3382 1436-1438 , denotes ,
T3383 1438-1442 VBP denotes have
T3384 1443-1447 VBN denotes been
T3362 1448-1458 VBN denotes classified
T3385 1459-1461 IN denotes as
T3386 1462-1471 JJ denotes resistant
T3387 1472-1474 CC denotes or
T3388 1475-1486 JJ denotes susceptible
T3389 1487-1489 IN denotes to
T3390 1490-1500 JJ denotes particular
T3392 1501-1508 JJ denotes complex
T3391 1509-1517 NNS denotes diseases
T3393 1518-1519 -LRB- denotes (
T3394 1519-1524 NN denotes Table
T3395 1525-1526 CD denotes 1
T3396 1526-1527 -RRB- denotes )
T3397 1527-1528 . denotes .
T3398 1528-1853 sentence denotes These two strains have diverse responses to diet-induced obesity [8] (B6 susceptible; A/J resistant), diet-induced atherosclerosis (B6 susceptible; A/J resistant) [9], arterial ligation-induced neointimal hyperplasia (B6 resistant; A/J resistant), and ligation induced vessel remodeling (B6 resistant; A/J susceptible) [10].
T3399 1529-1534 DT denotes These
T3401 1535-1538 CD denotes two
T3400 1539-1546 NNS denotes strains
T3402 1547-1551 VBP denotes have
T3403 1552-1559 JJ denotes diverse
T3404 1560-1569 NNS denotes responses
T3405 1570-1572 IN denotes to
T3406 1573-1577 NN denotes diet
T3408 1577-1578 HYPH denotes -
T3407 1578-1585 VBN denotes induced
T3409 1586-1593 NN denotes obesity
T3410 1594-1595 -LRB- denotes [
T3411 1595-1596 CD denotes 8
T3412 1596-1597 -RRB- denotes ]
T3413 1598-1599 -LRB- denotes (
T3415 1599-1601 NN denotes B6
T3416 1602-1613 JJ denotes susceptible
T3417 1613-1614 : denotes ;
T3418 1615-1616 NN denotes A
T3420 1616-1617 HYPH denotes /
T3419 1617-1618 NN denotes J
T3414 1619-1628 JJ denotes resistant
T3421 1628-1629 -RRB- denotes )
T3422 1629-1631 , denotes ,
T3423 1631-1635 NN denotes diet
T3425 1635-1636 HYPH denotes -
T3424 1636-1643 VBN denotes induced
T3426 1644-1659 NN denotes atherosclerosis
T3427 1660-1661 -LRB- denotes (
T3429 1661-1663 NN denotes B6
T3430 1664-1675 JJ denotes susceptible
T3431 1675-1676 : denotes ;
T3432 1677-1678 NN denotes A
T3434 1678-1679 HYPH denotes /
T3433 1679-1680 NN denotes J
T3428 1681-1690 JJ denotes resistant
T3435 1690-1691 -RRB- denotes )
T3436 1692-1693 -LRB- denotes [
T3437 1693-1694 CD denotes 9
T3438 1694-1695 -RRB- denotes ]
T3439 1695-1697 , denotes ,
T3440 1697-1705 JJ denotes arterial
T3441 1706-1714 NN denotes ligation
T3443 1714-1715 HYPH denotes -
T3442 1715-1722 VBN denotes induced
T3445 1723-1733 JJ denotes neointimal
T3444 1734-1745 NN denotes hyperplasia
T3446 1746-1747 -LRB- denotes (
T3448 1747-1749 NN denotes B6
T3449 1750-1759 JJ denotes resistant
T3450 1759-1760 : denotes ;
T3451 1761-1762 NN denotes A
T3453 1762-1763 HYPH denotes /
T3452 1763-1764 NN denotes J
T3447 1765-1774 JJ denotes resistant
T3454 1774-1775 -RRB- denotes )
T3455 1775-1777 , denotes ,
T3456 1777-1780 CC denotes and
T3457 1781-1789 NN denotes ligation
T3458 1790-1797 VBN denotes induced
T3460 1798-1804 NN denotes vessel
T3459 1805-1815 NN denotes remodeling
T3461 1816-1817 -LRB- denotes (
T3463 1817-1819 NN denotes B6
T3464 1820-1829 JJ denotes resistant
T3465 1829-1830 : denotes ;
T3466 1831-1832 NN denotes A
T3468 1832-1833 HYPH denotes /
T3467 1833-1834 NN denotes J
T3469 1835-1846 JJ denotes susceptible
T3470 1846-1847 -RRB- denotes )
T3471 1848-1849 -LRB- denotes [
T3462 1849-1851 CD denotes 10
T3472 1851-1852 -RRB- denotes ]
T3473 1852-1853 . denotes .
T3474 1853-1979 sentence denotes These conditions are predisposing to thrombosis per se, but these mice have not been systematically evaluated for thrombosis.
T3475 1854-1859 DT denotes These
T3476 1860-1870 NNS denotes conditions
T3477 1871-1874 VBP denotes are
T3478 1875-1887 VBG denotes predisposing
T3479 1888-1890 IN denotes to
T3480 1891-1901 NN denotes thrombosis
T3481 1902-1905 FW denotes per
T3482 1906-1908 FW denotes se
T3483 1908-1910 , denotes ,
T3484 1910-1913 CC denotes but
T3485 1914-1919 DT denotes these
T3486 1920-1924 NNS denotes mice
T3488 1925-1929 VBP denotes have
T3489 1930-1933 RB denotes not
T3490 1934-1938 VBN denotes been
T3491 1939-1953 RB denotes systematically
T3487 1954-1963 VBN denotes evaluated
T3492 1964-1967 IN denotes for
T3493 1968-1978 NN denotes thrombosis
T3494 1978-1979 . denotes .
T3495 1979-2116 sentence denotes Clot formation and lysis, which ultimately determine thrombosis, requires platelet aggregation, coagulation, and fibrinolytic functions.
T3496 1980-1984 NN denotes Clot
T3497 1985-1994 NN denotes formation
T3499 1995-1998 CC denotes and
T3500 1999-2004 NN denotes lysis
T3501 2004-2006 , denotes ,
T3502 2006-2011 WDT denotes which
T3504 2012-2022 RB denotes ultimately
T3503 2023-2032 VBP denotes determine
T3505 2033-2043 NN denotes thrombosis
T3506 2043-2045 , denotes ,
T3498 2045-2053 VBZ denotes requires
T3507 2054-2062 NN denotes platelet
T3508 2063-2074 NN denotes aggregation
T3509 2074-2076 , denotes ,
T3510 2076-2087 NN denotes coagulation
T3511 2087-2089 , denotes ,
T3512 2089-2092 CC denotes and
T3513 2093-2105 JJ denotes fibrinolytic
T3514 2106-2115 NNS denotes functions
T3515 2115-2116 . denotes .
T3516 2116-2213 sentence denotes Interactions among these pathways may occur and additional factors may modulate these processes.
T3517 2117-2129 NNS denotes Interactions
T3519 2130-2135 IN denotes among
T3520 2136-2141 DT denotes these
T3521 2142-2150 NNS denotes pathways
T3522 2151-2154 MD denotes may
T3518 2155-2160 VB denotes occur
T3523 2161-2164 CC denotes and
T3524 2165-2175 JJ denotes additional
T3525 2176-2183 NNS denotes factors
T3527 2184-2187 MD denotes may
T3526 2188-2196 VB denotes modulate
T3528 2197-2202 DT denotes these
T3529 2203-2212 NNS denotes processes
T3530 2212-2213 . denotes .
T3531 2213-2404 sentence denotes Identification of novel modulators and factors of these pathways can be identified by associating the phenotype with a location(s) on a specific chromosome, a quantitative trait locus (QTL).
T3532 2214-2228 NN denotes Identification
T3534 2229-2231 IN denotes of
T3535 2232-2237 JJ denotes novel
T3536 2238-2248 NNS denotes modulators
T3537 2249-2252 CC denotes and
T3538 2253-2260 NNS denotes factors
T3539 2261-2263 IN denotes of
T3540 2264-2269 DT denotes these
T3541 2270-2278 NNS denotes pathways
T3542 2279-2282 MD denotes can
T3543 2283-2285 VB denotes be
T3533 2286-2296 VBN denotes identified
T3544 2297-2299 IN denotes by
T3545 2300-2311 VBG denotes associating
T3546 2312-2315 DT denotes the
T3547 2316-2325 NN denotes phenotype
T3548 2326-2330 IN denotes with
T3549 2331-2332 DT denotes a
T3550 2333-2341 NN denotes location
T3551 2341-2342 -LRB- denotes (
T3552 2342-2343 AFX denotes s
T3553 2343-2344 -RRB- denotes )
T3554 2345-2347 IN denotes on
T3555 2348-2349 DT denotes a
T3557 2350-2358 JJ denotes specific
T3556 2359-2369 NN denotes chromosome
T3558 2369-2371 , denotes ,
T3559 2371-2372 DT denotes a
T3561 2373-2385 JJ denotes quantitative
T3562 2386-2391 NN denotes trait
T3560 2392-2397 NN denotes locus
T3563 2398-2399 -LRB- denotes (
T3564 2399-2402 NN denotes QTL
T3565 2402-2403 -RRB- denotes )
T3566 2403-2404 . denotes .
T3567 2404-2405 sentence denotes
T20564 2414-2428 NN denotes Identification
T20565 2429-2431 IN denotes of
T20566 2432-2436 NNS denotes mice
T20567 2437-2448 JJ denotes susceptible
T20568 2449-2451 CC denotes or
T20569 2452-2461 JJ denotes resistant
T20570 2462-2464 IN denotes to
T20571 2465-2472 NN denotes obesity
T20572 2472-2474 , denotes ,
T20573 2474-2489 NN denotes atherosclerosis
T20574 2489-2491 , denotes ,
T20575 2491-2494 CC denotes and
T20576 2495-2503 JJ denotes vascular
T20577 2504-2510 NN denotes injury
T3569 2997-2998 NN denotes A
T3568 2997-2999 sentence denotes A
T3571 2999-3004 NN denotes panel
T3570 2999-3188 sentence denotes panel of chromosome substitution strains (CSS) was generated [11] by a "marker-assisted" breeding program where the progeny of a B6 × A/J cross were successively backcrossed to the B6 mice.
T3573 3005-3007 IN denotes of
T3574 3008-3018 NN denotes chromosome
T3576 3019-3031 NN denotes substitution
T3575 3032-3039 NNS denotes strains
T3577 3040-3041 -LRB- denotes (
T3578 3041-3044 NNS denotes CSS
T3579 3044-3045 -RRB- denotes )
T3580 3046-3049 VBD denotes was
T3572 3050-3059 VBN denotes generated
T3581 3060-3061 -LRB- denotes [
T3582 3061-3063 CD denotes 11
T3583 3063-3064 -RRB- denotes ]
T3584 3065-3067 IN denotes by
T3585 3068-3069 DT denotes a
T3587 3070-3071 `` denotes "
T3588 3071-3077 NN denotes marker
T3590 3077-3078 HYPH denotes -
T3589 3078-3086 VBN denotes assisted
T3591 3086-3087 '' denotes "
T3592 3088-3096 NN denotes breeding
T3586 3097-3104 NN denotes program
T3593 3105-3110 WRB denotes where
T3595 3111-3114 DT denotes the
T3596 3115-3122 NN denotes progeny
T3597 3123-3125 IN denotes of
T3598 3126-3127 DT denotes a
T3600 3128-3130 NN denotes B6
T3601 3131-3132 SYM denotes ×
T3602 3133-3134 NN denotes A
T3604 3134-3135 HYPH denotes /
T3603 3135-3136 NN denotes J
T3599 3137-3142 NN denotes cross
T3605 3143-3147 VBD denotes were
T3606 3148-3160 RB denotes successively
T3594 3161-3172 VBN denotes backcrossed
T3607 3173-3175 IN denotes to
T3608 3176-3179 DT denotes the
T3610 3180-3182 NN denotes B6
T3609 3183-3187 NNS denotes mice
T3611 3187-3188 . denotes .
T3612 3188-3297 sentence denotes Genetic markers were used to identify homozygosity in the background (B6) and the individual A/J chromosome.
T3613 3189-3196 JJ denotes Genetic
T3614 3197-3204 NNS denotes markers
T3616 3205-3209 VBD denotes were
T3615 3210-3214 VBN denotes used
T3617 3215-3217 TO denotes to
T3618 3218-3226 VB denotes identify
T3619 3227-3239 NN denotes homozygosity
T3620 3240-3242 IN denotes in
T3621 3243-3246 DT denotes the
T3623 3247-3257 NN denotes background
T3624 3258-3259 -LRB- denotes (
T3622 3259-3261 NN denotes B6
T3625 3261-3262 -RRB- denotes )
T3626 3263-3266 CC denotes and
T3627 3267-3270 DT denotes the
T3629 3271-3281 JJ denotes individual
T3630 3282-3283 NN denotes A
T3631 3283-3284 HYPH denotes /
T3628 3284-3285 NN denotes J
T3632 3286-3296 NN denotes chromosome
T3633 3296-3297 . denotes .
T3634 3297-3365 sentence denotes These strains have one chromosome from A/J mice in a B6 background.
T3635 3298-3303 DT denotes These
T3636 3304-3311 NNS denotes strains
T3637 3312-3316 VBP denotes have
T3638 3317-3320 CD denotes one
T3639 3321-3331 NN denotes chromosome
T3640 3332-3336 IN denotes from
T3641 3337-3338 NN denotes A
T3643 3338-3339 HYPH denotes /
T3642 3339-3340 NN denotes J
T3644 3341-3345 NNS denotes mice
T3645 3346-3348 IN denotes in
T3646 3349-3350 DT denotes a
T3648 3351-3353 NN denotes B6
T3647 3354-3364 NN denotes background
T3649 3364-3365 . denotes .
T3650 3365-3488 sentence denotes This allows the identification of a trait in one or more CSS and implies that at least one QTL resides on this chromosome.
T3651 3366-3370 DT denotes This
T3652 3371-3377 VBZ denotes allows
T3653 3378-3381 DT denotes the
T3654 3382-3396 NN denotes identification
T3655 3397-3399 IN denotes of
T3656 3400-3401 DT denotes a
T3657 3402-3407 NN denotes trait
T3658 3408-3410 IN denotes in
T3659 3411-3414 CD denotes one
T3661 3415-3417 CC denotes or
T3662 3418-3422 JJR denotes more
T3660 3423-3426 NN denotes CSS
T3663 3427-3430 CC denotes and
T3664 3431-3438 VBZ denotes implies
T3665 3439-3443 IN denotes that
T3667 3444-3446 RB denotes at
T3669 3447-3452 RBS denotes least
T3668 3453-3456 CD denotes one
T3670 3457-3460 NN denotes QTL
T3666 3461-3468 VBZ denotes resides
T3671 3469-3471 IN denotes on
T3672 3472-3476 DT denotes this
T3673 3477-3487 NN denotes chromosome
T3674 3487-3488 . denotes .
T3675 3488-3577 sentence denotes Use of this panel requires fewer mice to determine the QTL than does a genome-wide scan.
T3676 3489-3492 NN denotes Use
T3678 3493-3495 IN denotes of
T3679 3496-3500 DT denotes this
T3680 3501-3506 NN denotes panel
T3677 3507-3515 VBZ denotes requires
T3681 3516-3521 JJR denotes fewer
T3682 3522-3526 NNS denotes mice
T3683 3527-3529 TO denotes to
T3684 3530-3539 VB denotes determine
T3685 3540-3543 DT denotes the
T3686 3544-3547 NN denotes QTL
T3687 3548-3552 IN denotes than
T3688 3553-3557 VBZ denotes does
T3689 3558-3559 DT denotes a
T3691 3560-3566 NN denotes genome
T3693 3566-3567 HYPH denotes -
T3692 3567-3571 JJ denotes wide
T3690 3572-3576 NN denotes scan
T3694 3576-3577 . denotes .
T3695 3577-3661 sentence denotes Another advantage is the ability for detection of QTL in the presence of other QTL.
T3696 3578-3585 DT denotes Another
T3697 3586-3595 NN denotes advantage
T3698 3596-3598 VBZ denotes is
T3699 3599-3602 DT denotes the
T3700 3603-3610 NN denotes ability
T3701 3611-3614 IN denotes for
T3702 3615-3624 NN denotes detection
T3703 3625-3627 IN denotes of
T3704 3628-3631 NNS denotes QTL
T3705 3632-3634 IN denotes in
T3706 3635-3638 DT denotes the
T3707 3639-3647 NN denotes presence
T3708 3648-3650 IN denotes of
T3709 3651-3656 JJ denotes other
T3710 3657-3660 NN denotes QTL
T3711 3660-3661 . denotes .
T3712 3661-3737 sentence denotes In addition, initial screens with the CSS simplify the fine-mapping of QTL.
T3713 3662-3664 IN denotes In
T3715 3665-3673 NN denotes addition
T3716 3673-3675 , denotes ,
T3717 3675-3682 JJ denotes initial
T3718 3683-3690 NNS denotes screens
T3719 3691-3695 IN denotes with
T3720 3696-3699 DT denotes the
T3721 3700-3703 NN denotes CSS
T3714 3704-3712 VBP denotes simplify
T3722 3713-3716 DT denotes the
T3724 3717-3721 RB denotes fine
T3725 3721-3722 HYPH denotes -
T3723 3722-3729 VBG denotes mapping
T3726 3730-3732 IN denotes of
T3727 3733-3736 NN denotes QTL
T3728 3736-3737 . denotes .
T3729 3737-3994 sentence denotes Several studies of this CSS panel, B6 Chr1-19, X, YA/J, have been reported for behavior [12], weight gain [13], sterols [13], and plasma amino acids levels [13,14], and have identified many more QTL than studies of the same traits using a genome-wide scan.
T3730 3738-3745 JJ denotes Several
T3731 3746-3753 NNS denotes studies
T3733 3754-3756 IN denotes of
T3734 3757-3761 DT denotes this
T3736 3762-3765 NN denotes CSS
T3735 3766-3771 NN denotes panel
T3737 3771-3773 , denotes ,
T3738 3773-3775 NN denotes B6
T3740 3776-3780 NN denotes Chr1
T3741 3780-3781 HYPH denotes -
T3739 3781-3783 NN denotes 19
T3742 3783-3785 , denotes ,
T3743 3785-3786 NN denotes X
T3744 3786-3788 , denotes ,
T3745 3788-3790 NN denotes YA
T3747 3790-3791 HYPH denotes /
T3746 3791-3792 NN denotes J
T3748 3792-3794 , denotes ,
T3749 3794-3798 VBP denotes have
T3750 3799-3803 VBN denotes been
T3732 3804-3812 VBN denotes reported
T3751 3813-3816 IN denotes for
T3752 3817-3825 NN denotes behavior
T3753 3826-3827 -LRB- denotes [
T3754 3827-3829 CD denotes 12
T3755 3829-3830 -RRB- denotes ]
T3756 3830-3832 , denotes ,
T3757 3832-3838 NN denotes weight
T3758 3839-3843 NN denotes gain
T3759 3844-3845 -LRB- denotes [
T3760 3845-3847 CD denotes 13
T3761 3847-3848 -RRB- denotes ]
T3762 3848-3850 , denotes ,
T3763 3850-3857 NNS denotes sterols
T3764 3858-3859 -LRB- denotes [
T3765 3859-3861 CD denotes 13
T3766 3861-3862 -RRB- denotes ]
T3767 3862-3864 , denotes ,
T3768 3864-3867 CC denotes and
T3769 3868-3874 NN denotes plasma
T3771 3875-3880 NN denotes amino
T3772 3881-3886 NNS denotes acids
T3770 3887-3893 NNS denotes levels
T3773 3894-3895 -LRB- denotes [
T3775 3895-3897 CD denotes 13
T3776 3897-3898 , denotes ,
T3774 3898-3900 CD denotes 14
T3777 3900-3901 -RRB- denotes ]
T3778 3901-3903 , denotes ,
T3779 3903-3906 CC denotes and
T3780 3907-3911 VBP denotes have
T3781 3912-3922 VBN denotes identified
T3782 3923-3927 JJ denotes many
T3783 3928-3932 JJR denotes more
T3784 3933-3936 NN denotes QTL
T3785 3937-3941 IN denotes than
T3786 3942-3949 NNS denotes studies
T3787 3950-3952 IN denotes of
T3788 3953-3956 DT denotes the
T3790 3957-3961 JJ denotes same
T3789 3962-3968 NNS denotes traits
T3791 3969-3974 VBG denotes using
T3792 3975-3976 DT denotes a
T3794 3977-3983 NN denotes genome
T3796 3983-3984 HYPH denotes -
T3795 3984-3988 JJ denotes wide
T3793 3989-3993 NN denotes scan
T3797 3993-3994 . denotes .
T3798 3994-4209 sentence denotes The purpose of this study was to evaluate the two inbred strains of mice for prothrombotic risk, utilizing a ferric chloride vascular injury model, tail bleeding assay, and measures of coagulation and fibrinolysis.
T3799 3995-3998 DT denotes The
T3800 3999-4006 NN denotes purpose
T3802 4007-4009 IN denotes of
T3803 4010-4014 DT denotes this
T3804 4015-4020 NN denotes study
T3801 4021-4024 VBD denotes was
T3805 4025-4027 TO denotes to
T3806 4028-4036 VB denotes evaluate
T3807 4037-4040 DT denotes the
T3809 4041-4044 CD denotes two
T3810 4045-4051 JJ denotes inbred
T3808 4052-4059 NNS denotes strains
T3811 4060-4062 IN denotes of
T3812 4063-4067 NNS denotes mice
T3813 4068-4071 IN denotes for
T3814 4072-4085 JJ denotes prothrombotic
T3815 4086-4090 NN denotes risk
T3816 4090-4092 , denotes ,
T3817 4092-4101 VBG denotes utilizing
T3818 4102-4103 DT denotes a
T3820 4104-4110 JJ denotes ferric
T3821 4111-4119 NN denotes chloride
T3822 4120-4128 JJ denotes vascular
T3823 4129-4135 NN denotes injury
T3819 4136-4141 NN denotes model
T3824 4141-4143 , denotes ,
T3825 4143-4147 NN denotes tail
T3826 4148-4156 NN denotes bleeding
T3827 4157-4162 NN denotes assay
T3828 4162-4164 , denotes ,
T3829 4164-4167 CC denotes and
T3830 4168-4176 NNS denotes measures
T3831 4177-4179 IN denotes of
T3832 4180-4191 NN denotes coagulation
T3833 4192-4195 CC denotes and
T3834 4196-4208 NN denotes fibrinolysis
T3835 4208-4209 . denotes .
T3836 4209-4379 sentence denotes The results of this study indicate that the two inbred strains, B6 and A/J mice, have diverse prothrombotic phenotypes, unrelated to coagulation or platelet aggregation.
T3837 4210-4213 DT denotes The
T3838 4214-4221 NNS denotes results
T3840 4222-4224 IN denotes of
T3841 4225-4229 DT denotes this
T3842 4230-4235 NN denotes study
T3839 4236-4244 VBP denotes indicate
T3843 4245-4249 IN denotes that
T3845 4250-4253 DT denotes the
T3847 4254-4257 CD denotes two
T3848 4258-4264 JJ denotes inbred
T3846 4265-4272 NNS denotes strains
T3849 4272-4274 , denotes ,
T3850 4274-4276 NN denotes B6
T3852 4277-4280 CC denotes and
T3853 4281-4282 NN denotes A
T3855 4282-4283 HYPH denotes /
T3854 4283-4284 NN denotes J
T3851 4285-4289 NNS denotes mice
T3856 4289-4291 , denotes ,
T3844 4291-4295 VBP denotes have
T3857 4296-4303 JJ denotes diverse
T3859 4304-4317 JJ denotes prothrombotic
T3858 4318-4328 NNS denotes phenotypes
T3860 4328-4330 , denotes ,
T3861 4330-4339 JJ denotes unrelated
T3862 4340-4342 IN denotes to
T3863 4343-4354 NN denotes coagulation
T3864 4355-4357 CC denotes or
T3865 4358-4366 NN denotes platelet
T3866 4367-4378 NN denotes aggregation
T3867 4378-4379 . denotes .
T3868 4379-4573 sentence denotes In addition, in the CSS, expression of the A/J phenotypes, rebleeding time and arterial occlusion, was modified in the B6 background, and suggested that interactions occurred among the A/J QTL.
T3869 4380-4382 IN denotes In
T3871 4383-4391 NN denotes addition
T3872 4391-4393 , denotes ,
T3873 4393-4395 IN denotes in
T3874 4396-4399 DT denotes the
T3875 4400-4403 NN denotes CSS
T3876 4403-4405 , denotes ,
T3877 4405-4415 NN denotes expression
T3878 4416-4418 IN denotes of
T3879 4419-4422 DT denotes the
T3881 4423-4424 NN denotes A
T3883 4424-4425 HYPH denotes /
T3882 4425-4426 NN denotes J
T3880 4427-4437 NNS denotes phenotypes
T3884 4437-4439 , denotes ,
T3885 4439-4449 NN denotes rebleeding
T3886 4450-4454 NN denotes time
T3887 4455-4458 CC denotes and
T3888 4459-4467 JJ denotes arterial
T3889 4468-4477 NN denotes occlusion
T3890 4477-4479 , denotes ,
T3891 4479-4482 VBD denotes was
T3870 4483-4491 VBN denotes modified
T3892 4492-4494 IN denotes in
T3893 4495-4498 DT denotes the
T3895 4499-4501 NN denotes B6
T3894 4502-4512 NN denotes background
T3896 4512-4514 , denotes ,
T3897 4514-4517 CC denotes and
T3898 4518-4527 VBD denotes suggested
T3899 4528-4532 IN denotes that
T3901 4533-4545 NNS denotes interactions
T3900 4546-4554 VBD denotes occurred
T3902 4555-4560 IN denotes among
T3903 4561-4564 DT denotes the
T3905 4565-4566 NN denotes A
T3907 4566-4567 HYPH denotes /
T3906 4567-4568 NN denotes J
T3904 4569-4572 NN denotes QTL
T3908 4572-4573 . denotes .
T3909 4573-4708 sentence denotes Thus, it should be possible to identify independent genetic determinants of susceptibility to pathological haemostasis and thrombosis.
T3910 4574-4578 RB denotes Thus
T3912 4578-4580 , denotes ,
T3913 4580-4582 PRP denotes it
T3914 4583-4589 MD denotes should
T3911 4590-4592 VB denotes be
T3915 4593-4601 JJ denotes possible
T3916 4602-4604 TO denotes to
T3917 4605-4613 VB denotes identify
T3918 4614-4625 JJ denotes independent
T3920 4626-4633 JJ denotes genetic
T3919 4634-4646 NNS denotes determinants
T3921 4647-4649 IN denotes of
T3922 4650-4664 NN denotes susceptibility
T3923 4665-4667 IN denotes to
T3924 4668-4680 JJ denotes pathological
T3925 4681-4692 NN denotes haemostasis
T3926 4693-4696 CC denotes and
T3927 4697-4707 NN denotes thrombosis
T3928 4707-4708 . denotes .
T4564 4719-4723 NNS denotes Mice
T4565 4723-4984 sentence denotes The inbred strains, B6 (#000664), Lepob (#000632), A/J (#000646) and gene-targeted plasminogen (Plg) activator inhibitor deficient mice (PAI-1-/-) (#002507) [15] mice in a B6 background were obtained from Jackson Laboratory (Bar Harbor, Maine) at 6 wks-of-age.
T4566 4724-4727 DT denotes The
T4568 4728-4734 JJ denotes inbred
T4567 4735-4742 NNS denotes strains
T4570 4742-4744 , denotes ,
T4571 4744-4746 NN denotes B6
T4572 4747-4748 -LRB- denotes (
T4573 4748-4749 NN denotes #
T4574 4749-4755 CD denotes 000664
T4575 4755-4756 -RRB- denotes )
T4576 4756-4758 , denotes ,
T4577 4758-4763 NN denotes Lepob
T4578 4764-4765 -LRB- denotes (
T4579 4765-4766 NN denotes #
T4580 4766-4772 CD denotes 000632
T4581 4772-4773 -RRB- denotes )
T4582 4773-4775 , denotes ,
T4583 4775-4776 NN denotes A
T4585 4776-4777 HYPH denotes /
T4584 4777-4778 NN denotes J
T4586 4779-4780 -LRB- denotes (
T4587 4780-4781 NN denotes #
T4588 4781-4787 CD denotes 000646
T4589 4787-4788 -RRB- denotes )
T4590 4789-4792 CC denotes and
T4591 4793-4797 NN denotes gene
T4593 4797-4798 HYPH denotes -
T4592 4798-4806 VBN denotes targeted
T4595 4807-4818 NN denotes plasminogen
T4597 4819-4820 -LRB- denotes (
T4598 4820-4823 NN denotes Plg
T4599 4823-4824 -RRB- denotes )
T4600 4825-4834 NN denotes activator
T4596 4835-4844 NN denotes inhibitor
T4601 4845-4854 JJ denotes deficient
T4594 4855-4859 NNS denotes mice
T4602 4860-4861 -LRB- denotes (
T4603 4861-4864 NN denotes PAI
T4605 4864-4865 HYPH denotes -
T4606 4865-4866 CD denotes 1
T4607 4866-4867 SYM denotes -
T4608 4867-4868 HYPH denotes /
T4609 4868-4869 SYM denotes -
T4610 4869-4870 -RRB- denotes )
T4611 4871-4872 -LRB- denotes (
T4612 4872-4873 NN denotes #
T4613 4873-4879 CD denotes 002507
T4614 4879-4880 -RRB- denotes )
T4615 4881-4882 -LRB- denotes [
T4616 4882-4884 CD denotes 15
T4617 4884-4885 -RRB- denotes ]
T4604 4886-4890 NNS denotes mice
T4618 4891-4893 IN denotes in
T4619 4894-4895 DT denotes a
T4621 4896-4898 NN denotes B6
T4620 4899-4909 NN denotes background
T4622 4910-4914 VBD denotes were
T4569 4915-4923 VBN denotes obtained
T4623 4924-4928 IN denotes from
T4624 4929-4936 NNP denotes Jackson
T4625 4937-4947 NNP denotes Laboratory
T4626 4948-4949 -LRB- denotes (
T4627 4949-4952 NNP denotes Bar
T4628 4953-4959 NNP denotes Harbor
T4629 4959-4961 , denotes ,
T4630 4961-4966 NNP denotes Maine
T4631 4966-4967 -RRB- denotes )
T4632 4968-4970 IN denotes at
T4633 4971-4972 CD denotes 6
T4634 4973-4976 NNS denotes wks
T4635 4976-4977 HYPH denotes -
T4636 4977-4979 IN denotes of
T4637 4979-4980 HYPH denotes -
T4638 4980-4983 NN denotes age
T4639 4983-4984 . denotes .
T4640 4984-5188 sentence denotes The Plg-/- mice were generated as previously described [16] and maintained in the B6 background, generated by crossing mice from the original mixed (B6:129) background for eight generations with B6 mice.
T4641 4985-4988 DT denotes The
T4643 4989-4992 NN denotes Plg
T4644 4992-4993 SYM denotes -
T4645 4993-4994 HYPH denotes /
T4646 4994-4995 SYM denotes -
T4642 4996-5000 NNS denotes mice
T4648 5001-5005 VBD denotes were
T4647 5006-5015 VBN denotes generated
T4649 5016-5018 IN denotes as
T4651 5019-5029 RB denotes previously
T4650 5030-5039 VBN denotes described
T4652 5040-5041 -LRB- denotes [
T4653 5041-5043 CD denotes 16
T4654 5043-5044 -RRB- denotes ]
T4655 5045-5048 CC denotes and
T4656 5049-5059 VBN denotes maintained
T4657 5060-5062 IN denotes in
T4658 5063-5066 DT denotes the
T4660 5067-5069 NN denotes B6
T4659 5070-5080 NN denotes background
T4661 5080-5082 , denotes ,
T4662 5082-5091 VBN denotes generated
T4663 5092-5094 IN denotes by
T4664 5095-5103 VBG denotes crossing
T4665 5104-5108 NNS denotes mice
T4666 5109-5113 IN denotes from
T4667 5114-5117 DT denotes the
T4669 5118-5126 JJ denotes original
T4670 5127-5132 JJ denotes mixed
T4671 5133-5134 -LRB- denotes (
T4672 5134-5136 NN denotes B6
T4673 5136-5137 HYPH denotes :
T4674 5137-5140 CD denotes 129
T4675 5140-5141 -RRB- denotes )
T4668 5142-5152 NN denotes background
T4676 5153-5156 IN denotes for
T4677 5157-5162 CD denotes eight
T4678 5163-5174 NNS denotes generations
T4679 5175-5179 IN denotes with
T4680 5180-5182 NN denotes B6
T4681 5183-5187 NNS denotes mice
T4682 5187-5188 . denotes .
T4683 5188-5277 sentence denotes The Plg-/- mice do not reproduce well and Plg heterozygous pairs were used for breeding.
T4684 5189-5192 DT denotes The
T4686 5193-5196 NN denotes Plg
T4687 5196-5197 SYM denotes -
T4688 5197-5198 HYPH denotes /
T4689 5198-5199 SYM denotes -
T4685 5200-5204 NNS denotes mice
T4691 5205-5207 VBP denotes do
T4692 5208-5211 RB denotes not
T4690 5212-5221 VB denotes reproduce
T4693 5222-5226 RB denotes well
T4694 5227-5230 CC denotes and
T4695 5231-5234 NN denotes Plg
T4697 5235-5247 JJ denotes heterozygous
T4696 5248-5253 NNS denotes pairs
T4699 5254-5258 VBD denotes were
T4698 5259-5263 VBN denotes used
T4700 5264-5267 IN denotes for
T4701 5268-5276 NN denotes breeding
T4702 5276-5277 . denotes .
T4703 5277-5404 sentence denotes Genotypes (Plg+/+, Plg+/-, Plg-/-) of the offspring were determined by a PCR assay at 3–4 weeks-of-age from an ear punch [17].
T4704 5278-5287 NNS denotes Genotypes
T4706 5288-5289 -LRB- denotes (
T4707 5289-5292 NN denotes Plg
T4708 5292-5293 SYM denotes +
T4709 5293-5294 HYPH denotes /
T4710 5294-5295 SYM denotes +
T4711 5295-5297 , denotes ,
T4712 5297-5300 NN denotes Plg
T4713 5300-5301 SYM denotes +
T4714 5301-5302 HYPH denotes /
T4715 5302-5303 SYM denotes -
T4716 5303-5305 , denotes ,
T4717 5305-5308 NN denotes Plg
T4718 5308-5309 SYM denotes -
T4719 5309-5310 HYPH denotes /
T4720 5310-5311 SYM denotes -
T4721 5311-5312 -RRB- denotes )
T4722 5313-5315 IN denotes of
T4723 5316-5319 DT denotes the
T4724 5320-5329 NN denotes offspring
T4725 5330-5334 VBD denotes were
T4705 5335-5345 VBN denotes determined
T4726 5346-5348 IN denotes by
T4727 5349-5350 DT denotes a
T4729 5351-5354 NN denotes PCR
T4728 5355-5360 NN denotes assay
T4730 5361-5363 IN denotes at
T4731 5364-5365 CD denotes 3
T4733 5365-5366 SYM denotes –
T4732 5366-5367 CD denotes 4
T4734 5368-5373 NNS denotes weeks
T4735 5373-5374 HYPH denotes -
T4736 5374-5376 IN denotes of
T4737 5376-5377 HYPH denotes -
T4738 5377-5380 NN denotes age
T4739 5381-5385 IN denotes from
T4740 5386-5388 DT denotes an
T4742 5389-5392 NN denotes ear
T4741 5393-5398 NN denotes punch
T4743 5399-5400 -LRB- denotes [
T4744 5400-5402 CD denotes 17
T4745 5402-5403 -RRB- denotes ]
T4746 5403-5404 . denotes .
T4747 5404-5482 sentence denotes Breeding pairs of the CSS mice were transferred from Dr. Nadeau's laboratory.
T4748 5405-5413 NN denotes Breeding
T4749 5414-5419 NNS denotes pairs
T4751 5420-5422 IN denotes of
T4752 5423-5426 DT denotes the
T4754 5427-5430 NN denotes CSS
T4753 5431-5435 NNS denotes mice
T4755 5436-5440 VBD denotes were
T4750 5441-5452 VBN denotes transferred
T4756 5453-5457 IN denotes from
T4757 5458-5461 NNP denotes Dr.
T4758 5462-5468 NNP denotes Nadeau
T4760 5468-5470 POS denotes 's
T4759 5471-5481 NN denotes laboratory
T4761 5481-5482 . denotes .
T4762 5482-5586 sentence denotes All mice were housed and bred in the Biological Resource Unit at the Cleveland Clinic Foundation (CCF).
T4763 5483-5486 DT denotes All
T4764 5487-5491 NNS denotes mice
T4766 5492-5496 VBD denotes were
T4765 5497-5503 VBN denotes housed
T4767 5504-5507 CC denotes and
T4768 5508-5512 VBN denotes bred
T4769 5513-5515 IN denotes in
T4770 5516-5519 DT denotes the
T4772 5520-5530 NNP denotes Biological
T4773 5531-5539 NNP denotes Resource
T4771 5540-5544 NNP denotes Unit
T4774 5545-5547 IN denotes at
T4775 5548-5551 DT denotes the
T4777 5552-5561 NNP denotes Cleveland
T4778 5562-5568 NNP denotes Clinic
T4776 5569-5579 NNP denotes Foundation
T4779 5580-5581 -LRB- denotes (
T4780 5581-5584 NN denotes CCF
T4781 5584-5585 -RRB- denotes )
T4782 5585-5586 . denotes .
T4783 5586-5735 sentence denotes Mice were housed in sterilized isolator cages, maintained on a 14 hr light/10 hr dark cycle, and were provided sterilized food and water ad libitum.
T4784 5587-5591 NNS denotes Mice
T4786 5592-5596 VBD denotes were
T4785 5597-5603 VBN denotes housed
T4787 5604-5606 IN denotes in
T4788 5607-5617 VBN denotes sterilized
T4790 5618-5626 NN denotes isolator
T4789 5627-5632 NNS denotes cages
T4791 5632-5634 , denotes ,
T4792 5634-5644 VBN denotes maintained
T4793 5645-5647 IN denotes on
T4794 5648-5649 DT denotes a
T4796 5650-5652 CD denotes 14
T4797 5653-5655 NN denotes hr
T4798 5656-5661 NN denotes light
T4799 5661-5662 HYPH denotes /
T4800 5662-5664 CD denotes 10
T4801 5665-5667 NN denotes hr
T4802 5668-5672 NN denotes dark
T4795 5673-5678 NN denotes cycle
T4803 5678-5680 , denotes ,
T4804 5680-5683 CC denotes and
T4805 5684-5688 VBD denotes were
T4806 5689-5697 VBN denotes provided
T4807 5698-5708 VBN denotes sterilized
T4808 5709-5713 NN denotes food
T4809 5714-5717 CC denotes and
T4810 5718-5723 NN denotes water
T4811 5724-5726 FW denotes ad
T4812 5727-5734 FW denotes libitum
T4813 5734-5735 . denotes .
T4814 5735-5901 sentence denotes Mice were fed a standard autoclavable laboratory diet consisting of: 23% protein, 4.5% fat, 6% fiber, (Purina, St. Louis, MO), and tested between 7 and 9 wks-of-age.
T4815 5736-5740 NNS denotes Mice
T4817 5741-5745 VBD denotes were
T4816 5746-5749 VBN denotes fed
T4818 5750-5751 DT denotes a
T4820 5752-5760 JJ denotes standard
T4821 5761-5773 JJ denotes autoclavable
T4822 5774-5784 NN denotes laboratory
T4819 5785-5789 NN denotes diet
T4823 5790-5800 VBG denotes consisting
T4824 5801-5803 IN denotes of
T4825 5803-5805 : denotes :
T4826 5805-5807 CD denotes 23
T4827 5807-5808 NN denotes %
T4828 5809-5816 NN denotes protein
T4829 5816-5818 , denotes ,
T4830 5818-5821 CD denotes 4.5
T4831 5821-5822 NN denotes %
T4832 5823-5826 NN denotes fat
T4833 5826-5828 , denotes ,
T4834 5828-5829 CD denotes 6
T4835 5829-5830 NN denotes %
T4836 5831-5836 NN denotes fiber
T4837 5836-5838 , denotes ,
T4838 5838-5839 -LRB- denotes (
T4839 5839-5845 NNP denotes Purina
T4840 5845-5847 , denotes ,
T4841 5847-5850 NNP denotes St.
T4842 5851-5856 NNP denotes Louis
T4843 5856-5858 , denotes ,
T4844 5858-5860 NNP denotes MO
T4845 5860-5861 -RRB- denotes )
T4846 5861-5863 , denotes ,
T4847 5863-5866 CC denotes and
T4848 5867-5873 VBN denotes tested
T4849 5874-5881 IN denotes between
T4850 5882-5883 CD denotes 7
T4852 5884-5887 CC denotes and
T4853 5888-5889 CD denotes 9
T4851 5890-5893 NNS denotes wks
T4854 5893-5894 HYPH denotes -
T4855 5894-5896 IN denotes of
T4856 5896-5897 HYPH denotes -
T4857 5897-5900 NN denotes age
T4858 5900-5901 . denotes .
T4859 5901-6051 sentence denotes All animal experiments were performed in accordance with a protocol approved by the Institutional Animal Care and Research Advisory Committee at CCF.
T4860 5902-5905 DT denotes All
T4862 5906-5912 NN denotes animal
T4861 5913-5924 NNS denotes experiments
T4864 5925-5929 VBD denotes were
T4863 5930-5939 VBN denotes performed
T4865 5940-5942 IN denotes in
T4866 5943-5953 NN denotes accordance
T4867 5954-5958 IN denotes with
T4868 5959-5960 DT denotes a
T4869 5961-5969 NN denotes protocol
T4870 5970-5978 VBN denotes approved
T4871 5979-5981 IN denotes by
T4872 5982-5985 DT denotes the
T4874 5986-5999 NNP denotes Institutional
T4875 6000-6006 NNP denotes Animal
T4876 6007-6011 NNP denotes Care
T4877 6012-6015 CC denotes and
T4878 6016-6024 NNP denotes Research
T4879 6025-6033 NNP denotes Advisory
T4873 6034-6043 NNP denotes Committee
T4880 6044-6046 IN denotes at
T4881 6047-6050 NNP denotes CCF
T4882 6050-6051 . denotes .
T5305 6053-6061 JJ denotes Vascular
T5306 6062-6068 NN denotes injury
T5307 6068-6193 sentence denotes To induce thrombosis formation in the carotid artery, a ferric chloride (FeCl3) model of vessel injury [18,19] was employed.
T5308 6069-6071 TO denotes To
T5309 6072-6078 VB denotes induce
T5311 6079-6089 NN denotes thrombosis
T5312 6090-6099 NN denotes formation
T5313 6100-6102 IN denotes in
T5314 6103-6106 DT denotes the
T5316 6107-6114 NN denotes carotid
T5315 6115-6121 NN denotes artery
T5317 6121-6123 , denotes ,
T5318 6123-6124 DT denotes a
T5320 6125-6131 JJ denotes ferric
T5321 6132-6140 NN denotes chloride
T5322 6141-6142 -LRB- denotes (
T5323 6142-6147 NN denotes FeCl3
T5324 6147-6148 -RRB- denotes )
T5319 6149-6154 NN denotes model
T5325 6155-6157 IN denotes of
T5326 6158-6164 NN denotes vessel
T5327 6165-6171 NN denotes injury
T5328 6172-6173 -LRB- denotes [
T5330 6173-6175 CD denotes 18
T5331 6175-6176 , denotes ,
T5329 6176-6178 CD denotes 19
T5332 6178-6179 -RRB- denotes ]
T5333 6180-6183 VBD denotes was
T5310 6184-6192 VBN denotes employed
T5334 6192-6193 . denotes .
T5335 6193-6362 sentence denotes Mice were anesthetized with ketamine/xylazine (80 mg/kg, 5 mg/kg), a midline cervical incision was made and the left common carotid artery isolated by blunt dissection.
T5336 6194-6198 NNS denotes Mice
T5338 6199-6203 VBD denotes were
T5337 6204-6216 VBN denotes anesthetized
T5339 6217-6221 IN denotes with
T5340 6222-6230 NN denotes ketamine
T5342 6230-6231 HYPH denotes /
T5341 6231-6239 NN denotes xylazine
T5343 6240-6241 -LRB- denotes (
T5345 6241-6243 CD denotes 80
T5346 6244-6246 NNS denotes mg
T5347 6246-6247 SYM denotes /
T5348 6247-6249 NN denotes kg
T5349 6249-6251 , denotes ,
T5350 6251-6252 CD denotes 5
T5344 6253-6255 NNS denotes mg
T5351 6255-6256 SYM denotes /
T5352 6256-6258 NN denotes kg
T5353 6258-6259 -RRB- denotes )
T5354 6259-6261 , denotes ,
T5355 6261-6262 DT denotes a
T5357 6263-6270 NN denotes midline
T5358 6271-6279 JJ denotes cervical
T5356 6280-6288 NN denotes incision
T5360 6289-6292 VBD denotes was
T5359 6293-6297 VBN denotes made
T5361 6298-6301 CC denotes and
T5362 6302-6305 DT denotes the
T5364 6306-6310 JJ denotes left
T5365 6311-6317 JJ denotes common
T5366 6318-6325 JJ denotes carotid
T5363 6326-6332 NN denotes artery
T5367 6333-6341 VBN denotes isolated
T5368 6342-6344 IN denotes by
T5369 6345-6350 JJ denotes blunt
T5370 6351-6361 NN denotes dissection
T5371 6361-6362 . denotes .
T5372 6362-6608 sentence denotes The flow probe (Transonic Systems, model 0.5PSB) was placed under the artery and when a stable baseline was reached, a 0.5 × 2 mm strip of filter paper saturated with 10% FeCl3 solution was applied to the surface of the carotid artery for 3 min.
T5373 6363-6366 DT denotes The
T5375 6367-6371 NN denotes flow
T5374 6372-6377 NN denotes probe
T5377 6378-6379 -LRB- denotes (
T5379 6379-6388 NNP denotes Transonic
T5380 6389-6396 NNP denotes Systems
T5381 6396-6398 , denotes ,
T5382 6398-6403 NN denotes model
T5378 6404-6410 NN denotes 0.5PSB
T5383 6410-6411 -RRB- denotes )
T5384 6412-6415 VBD denotes was
T5376 6416-6422 VBN denotes placed
T5385 6423-6428 IN denotes under
T5386 6429-6432 DT denotes the
T5387 6433-6439 NN denotes artery
T5388 6440-6443 CC denotes and
T5389 6444-6448 WRB denotes when
T5391 6449-6450 DT denotes a
T5393 6451-6457 JJ denotes stable
T5392 6458-6466 NN denotes baseline
T5394 6467-6470 VBD denotes was
T5390 6471-6478 VBN denotes reached
T5396 6478-6480 , denotes ,
T5397 6480-6481 DT denotes a
T5399 6482-6485 CD denotes 0.5
T5401 6486-6487 SYM denotes ×
T5400 6488-6489 CD denotes 2
T5402 6490-6492 NN denotes mm
T5398 6493-6498 NN denotes strip
T5403 6499-6501 IN denotes of
T5404 6502-6508 NN denotes filter
T5405 6509-6514 NN denotes paper
T5406 6515-6524 VBN denotes saturated
T5407 6525-6529 IN denotes with
T5408 6530-6532 CD denotes 10
T5409 6532-6533 NN denotes %
T5410 6534-6539 NN denotes FeCl3
T5411 6540-6548 NN denotes solution
T5412 6549-6552 VBD denotes was
T5395 6553-6560 VBN denotes applied
T5413 6561-6563 IN denotes to
T5414 6564-6567 DT denotes the
T5415 6568-6575 NN denotes surface
T5416 6576-6578 IN denotes of
T5417 6579-6582 DT denotes the
T5419 6583-6590 JJ denotes carotid
T5418 6591-6597 NN denotes artery
T5420 6598-6601 IN denotes for
T5421 6602-6603 CD denotes 3
T5422 6604-6607 NNS denotes min
T5423 6607-6608 . denotes .
T5424 6608-6731 sentence denotes Occlusion time was determined from the addition of the FeCl3 solution to the occlusion of the artery (minimum blood flow).
T5425 6609-6618 NN denotes Occlusion
T5426 6619-6623 NN denotes time
T5428 6624-6627 VBD denotes was
T5427 6628-6638 VBN denotes determined
T5429 6639-6643 IN denotes from
T5430 6644-6647 DT denotes the
T5431 6648-6656 NN denotes addition
T5432 6657-6659 IN denotes of
T5433 6660-6663 DT denotes the
T5435 6664-6669 NN denotes FeCl3
T5434 6670-6678 NN denotes solution
T5436 6679-6681 IN denotes to
T5437 6682-6685 DT denotes the
T5438 6686-6695 NN denotes occlusion
T5439 6696-6698 IN denotes of
T5440 6699-6702 DT denotes the
T5441 6703-6709 NN denotes artery
T5442 6710-6711 -LRB- denotes (
T5443 6711-6718 NN denotes minimum
T5445 6719-6724 NN denotes blood
T5444 6725-6729 NN denotes flow
T5446 6729-6730 -RRB- denotes )
T5447 6730-6731 . denotes .
T5448 6731-6905 sentence denotes The flow probe was in place from the establishment of the baseline until several min after the stable occlusion had been reached or stopped at 30 min if it had not occluded.
T5449 6732-6735 DT denotes The
T5451 6736-6740 NN denotes flow
T5450 6741-6746 NN denotes probe
T5452 6747-6750 VBD denotes was
T5453 6751-6753 IN denotes in
T5454 6754-6759 NN denotes place
T5455 6760-6764 IN denotes from
T5456 6765-6768 DT denotes the
T5457 6769-6782 NN denotes establishment
T5458 6783-6785 IN denotes of
T5459 6786-6789 DT denotes the
T5460 6790-6798 NN denotes baseline
T5461 6799-6804 IN denotes until
T5462 6805-6812 JJ denotes several
T5463 6813-6816 NNS denotes min
T5465 6817-6822 IN denotes after
T5466 6823-6826 DT denotes the
T5468 6827-6833 JJ denotes stable
T5467 6834-6843 NN denotes occlusion
T5469 6844-6847 VBD denotes had
T5470 6848-6852 VBN denotes been
T5464 6853-6860 VBN denotes reached
T5471 6861-6863 CC denotes or
T5472 6864-6871 VBD denotes stopped
T5473 6872-6874 IN denotes at
T5474 6875-6877 CD denotes 30
T5475 6878-6881 NNS denotes min
T5476 6882-6884 IN denotes if
T5478 6885-6887 PRP denotes it
T5479 6888-6891 VBD denotes had
T5480 6892-6895 RB denotes not
T5477 6896-6904 VBN denotes occluded
T5481 6904-6905 . denotes .
T5482 6905-6976 sentence denotes Blood flow was recorded every 10 sec (Transonic Systems, model TS420).
T5483 6906-6911 NN denotes Blood
T5484 6912-6916 NN denotes flow
T5486 6917-6920 VBD denotes was
T5485 6921-6929 VBN denotes recorded
T5487 6930-6935 DT denotes every
T5489 6936-6938 CD denotes 10
T5488 6939-6942 NN denotes sec
T5490 6943-6944 -LRB- denotes (
T5492 6944-6953 NNP denotes Transonic
T5493 6954-6961 NNP denotes Systems
T5494 6961-6963 , denotes ,
T5495 6963-6968 NN denotes model
T5491 6969-6974 NN denotes TS420
T5496 6974-6975 -RRB- denotes )
T5497 6975-6976 . denotes .
T5498 6976-7077 sentence denotes There was no difference in body weight among the mice that were tested in the vascular injury model.
T5499 6977-6982 EX denotes There
T5500 6983-6986 VBD denotes was
T5501 6987-6989 DT denotes no
T5502 6990-7000 NN denotes difference
T5503 7001-7003 IN denotes in
T5504 7004-7008 NN denotes body
T5505 7009-7015 NN denotes weight
T5506 7016-7021 IN denotes among
T5507 7022-7025 DT denotes the
T5508 7026-7030 NNS denotes mice
T5509 7031-7035 WDT denotes that
T5511 7036-7040 VBD denotes were
T5510 7041-7047 VBN denotes tested
T5512 7048-7050 IN denotes in
T5513 7051-7054 DT denotes the
T5515 7055-7063 JJ denotes vascular
T5516 7064-7070 NN denotes injury
T5514 7071-7076 NN denotes model
T5517 7076-7077 . denotes .
T5752 7079-7087 NN denotes Bleeding
T5754 7088-7091 CC denotes and
T5755 7092-7102 NN denotes rebleeding
T5753 7103-7108 NN denotes assay
T5756 7108-7277 sentence denotes For the tail bleeding assay, mice were anesthetized with ketamine/xylazine (80 mg/kg, 5 mg/kg), the tail prewarmed for 5 min in 10 mL of saline at 37°C in a water bath.
T5757 7109-7112 IN denotes For
T5759 7113-7116 DT denotes the
T5761 7117-7121 NN denotes tail
T5762 7122-7130 NN denotes bleeding
T5760 7131-7136 NN denotes assay
T5763 7136-7138 , denotes ,
T5764 7138-7142 NNS denotes mice
T5765 7143-7147 VBD denotes were
T5758 7148-7160 VBN denotes anesthetized
T5767 7161-7165 IN denotes with
T5768 7166-7174 NN denotes ketamine
T5770 7174-7175 HYPH denotes /
T5769 7175-7183 NN denotes xylazine
T5771 7184-7185 -LRB- denotes (
T5773 7185-7187 CD denotes 80
T5774 7188-7190 NNS denotes mg
T5775 7190-7191 SYM denotes /
T5776 7191-7193 NN denotes kg
T5777 7193-7195 , denotes ,
T5778 7195-7196 CD denotes 5
T5772 7197-7199 NNS denotes mg
T5779 7199-7200 SYM denotes /
T5780 7200-7202 NN denotes kg
T5781 7202-7203 -RRB- denotes )
T5782 7203-7205 , denotes ,
T5783 7205-7208 DT denotes the
T5784 7209-7213 NN denotes tail
T5766 7214-7223 VBN denotes prewarmed
T5785 7224-7227 IN denotes for
T5786 7228-7229 CD denotes 5
T5787 7230-7233 NNS denotes min
T5788 7234-7236 IN denotes in
T5789 7237-7239 CD denotes 10
T5790 7240-7242 NNS denotes mL
T5791 7243-7245 IN denotes of
T5792 7246-7252 NN denotes saline
T5793 7253-7255 IN denotes at
T5794 7256-7258 CD denotes 37
T5795 7258-7260 NNS denotes °C
T5796 7261-7263 IN denotes in
T5797 7264-7265 DT denotes a
T5799 7266-7271 NN denotes water
T5798 7272-7276 NN denotes bath
T5800 7276-7277 . denotes .
T5801 7277-7387 sentence denotes The tail was lifted from the saline and a 5 mm tail segment amputated and immediately returned to the saline.
T5802 7278-7281 DT denotes The
T5803 7282-7286 NN denotes tail
T5805 7287-7290 VBD denotes was
T5804 7291-7297 VBN denotes lifted
T5806 7298-7302 IN denotes from
T5807 7303-7306 DT denotes the
T5808 7307-7313 NN denotes saline
T5809 7314-7317 CC denotes and
T5810 7318-7319 DT denotes a
T5812 7320-7321 CD denotes 5
T5813 7322-7324 NN denotes mm
T5814 7325-7329 NN denotes tail
T5811 7330-7337 NN denotes segment
T5815 7338-7347 VBN denotes amputated
T5816 7348-7351 CC denotes and
T5817 7352-7363 RB denotes immediately
T5818 7364-7372 VBD denotes returned
T5819 7373-7375 IN denotes to
T5820 7376-7379 DT denotes the
T5821 7380-7386 NN denotes saline
T5822 7386-7387 . denotes .
T5823 7387-7482 sentence denotes Bleeding time was measured as the time between the start of bleeding to cessation of bleeding.
T5824 7388-7396 NN denotes Bleeding
T5825 7397-7401 NN denotes time
T5827 7402-7405 VBD denotes was
T5826 7406-7414 VBN denotes measured
T5828 7415-7417 IN denotes as
T5829 7418-7421 DT denotes the
T5830 7422-7426 NN denotes time
T5831 7427-7434 IN denotes between
T5832 7435-7438 DT denotes the
T5833 7439-7444 NN denotes start
T5834 7445-7447 IN denotes of
T5835 7448-7456 VBG denotes bleeding
T5836 7457-7459 IN denotes to
T5837 7460-7469 NN denotes cessation
T5838 7470-7472 IN denotes of
T5839 7473-7481 NN denotes bleeding
T5840 7481-7482 . denotes .
T5841 7482-7647 sentence denotes With the tail remaining in the same saline solution, the rebleeding time was measured from the time between bleeding cessation and the start of the second bleeding.
T5842 7483-7487 IN denotes With
T5844 7488-7491 DT denotes the
T5845 7492-7496 NN denotes tail
T5846 7497-7506 VBG denotes remaining
T5847 7507-7509 IN denotes in
T5848 7510-7513 DT denotes the
T5850 7514-7518 JJ denotes same
T5851 7519-7525 NN denotes saline
T5849 7526-7534 NN denotes solution
T5852 7534-7536 , denotes ,
T5853 7536-7539 DT denotes the
T5855 7540-7550 NN denotes rebleeding
T5854 7551-7555 NN denotes time
T5856 7556-7559 VBD denotes was
T5843 7560-7568 VBN denotes measured
T5857 7569-7573 IN denotes from
T5858 7574-7577 DT denotes the
T5859 7578-7582 NN denotes time
T5860 7583-7590 IN denotes between
T5861 7591-7599 NN denotes bleeding
T5862 7600-7609 NN denotes cessation
T5863 7610-7613 CC denotes and
T5864 7614-7617 DT denotes the
T5865 7618-7623 NN denotes start
T5866 7624-7626 IN denotes of
T5867 7627-7630 DT denotes the
T5869 7631-7637 JJ denotes second
T5868 7638-7646 NN denotes bleeding
T5870 7646-7647 . denotes .
T6393 7649-7660 NN denotes Coagulation
T6395 7660-7662 , denotes ,
T6396 7662-7665 NN denotes Plg
T6397 7665-7667 , denotes ,
T6398 7667-7669 NN denotes α2
T6400 7669-7670 HYPH denotes -
T6399 7670-7681 NN denotes antiplasmin
T6401 7681-7683 , denotes ,
T6402 7683-7693 NN denotes fibrinogen
T6403 7693-7695 , denotes ,
T6404 7695-7707 JJ denotes fibrinolytic
T6405 7708-7711 CC denotes and
T6406 7712-7715 NN denotes PAI
T6407 7715-7716 HYPH denotes -
T6408 7716-7717 CD denotes 1
T6394 7718-7724 NNS denotes assays
T6409 7724-8072 sentence denotes Mice were anesthetized with Isoflurane (Abbott), bled from the orbital sinus into uncoated capillary tubes, and a drop of blood immediately placed on a reagent strip (Synbiotics) for prothrombin time (PT) or activated partial thromboplastin time (aPTT) determinations and inserted into the precalibrated Coagulation Analyzer (SCA2000, Synbiotics).
T6410 7725-7729 NNS denotes Mice
T6412 7730-7734 VBD denotes were
T6411 7735-7747 VBN denotes anesthetized
T6413 7748-7752 IN denotes with
T6414 7753-7763 NN denotes Isoflurane
T6415 7764-7765 -LRB- denotes (
T6416 7765-7771 NNP denotes Abbott
T6417 7771-7772 -RRB- denotes )
T6418 7772-7774 , denotes ,
T6419 7774-7778 VBN denotes bled
T6420 7779-7783 IN denotes from
T6421 7784-7787 DT denotes the
T6423 7788-7795 JJ denotes orbital
T6422 7796-7801 NN denotes sinus
T6424 7802-7806 IN denotes into
T6425 7807-7815 JJ denotes uncoated
T6427 7816-7825 JJ denotes capillary
T6426 7826-7831 NNS denotes tubes
T6428 7831-7833 , denotes ,
T6429 7833-7836 CC denotes and
T6430 7837-7838 DT denotes a
T6431 7839-7843 NN denotes drop
T6433 7844-7846 IN denotes of
T6434 7847-7852 NN denotes blood
T6435 7853-7864 RB denotes immediately
T6432 7865-7871 VBN denotes placed
T6436 7872-7874 IN denotes on
T6437 7875-7876 DT denotes a
T6439 7877-7884 NN denotes reagent
T6438 7885-7890 NN denotes strip
T6440 7891-7892 -LRB- denotes (
T6441 7892-7902 NNP denotes Synbiotics
T6442 7902-7903 -RRB- denotes )
T6443 7904-7907 IN denotes for
T6444 7908-7919 NN denotes prothrombin
T6445 7920-7924 NN denotes time
T6447 7925-7926 -LRB- denotes (
T6448 7926-7928 NN denotes PT
T6449 7928-7929 -RRB- denotes )
T6450 7930-7932 CC denotes or
T6451 7933-7942 VBN denotes activated
T6453 7943-7950 JJ denotes partial
T6454 7951-7965 NN denotes thromboplastin
T6452 7966-7970 NN denotes time
T6455 7971-7972 -LRB- denotes (
T6456 7972-7976 NN denotes aPTT
T6457 7976-7977 -RRB- denotes )
T6446 7978-7992 NNS denotes determinations
T6458 7993-7996 CC denotes and
T6459 7997-8005 VBN denotes inserted
T6460 8006-8010 IN denotes into
T6461 8011-8014 DT denotes the
T6463 8015-8028 VBN denotes precalibrated
T6464 8029-8040 NNP denotes Coagulation
T6462 8041-8049 NNP denotes Analyzer
T6465 8050-8051 -LRB- denotes (
T6467 8051-8058 NNP denotes SCA2000
T6468 8058-8060 , denotes ,
T6466 8060-8070 NNP denotes Synbiotics
T6469 8070-8071 -RRB- denotes )
T6470 8071-8072 . denotes .
T6471 8072-8150 sentence denotes PAI-1 activity was determined according to the method of Chandler et al [20].
T6472 8073-8076 NN denotes PAI
T6474 8076-8077 HYPH denotes -
T6475 8077-8078 CD denotes 1
T6473 8079-8087 NN denotes activity
T6477 8088-8091 VBD denotes was
T6476 8092-8102 VBN denotes determined
T6478 8103-8112 VBG denotes according
T6479 8113-8115 IN denotes to
T6480 8116-8119 DT denotes the
T6481 8120-8126 NN denotes method
T6482 8127-8129 IN denotes of
T6483 8130-8138 NNP denotes Chandler
T6484 8139-8141 FW denotes et
T6485 8142-8144 FW denotes al
T6486 8145-8146 -LRB- denotes [
T6487 8146-8148 CD denotes 20
T6488 8148-8149 -RRB- denotes ]
T6489 8149-8150 . denotes .
T6490 8150-8353 sentence denotes PAI-1 antigen concentration was determined by ELISA [21] using sheep-anti mouse PAI-1 (American Diagnostica) as the capture antibody and mouse PAI-1 (American Diagnostica) as the standard (0–3.5 ng/mL).
T6491 8151-8154 NN denotes PAI
T6493 8154-8155 HYPH denotes -
T6494 8155-8156 CD denotes 1
T6495 8157-8164 NN denotes antigen
T6492 8165-8178 NN denotes concentration
T6497 8179-8182 VBD denotes was
T6496 8183-8193 VBN denotes determined
T6498 8194-8196 IN denotes by
T6499 8197-8202 NNP denotes ELISA
T6500 8203-8204 -LRB- denotes [
T6501 8204-8206 CD denotes 21
T6502 8206-8207 -RRB- denotes ]
T6503 8208-8213 VBG denotes using
T6504 8214-8219 NN denotes sheep
T6506 8219-8220 HYPH denotes -
T6507 8220-8224 AFX denotes anti
T6508 8225-8230 NN denotes mouse
T6505 8231-8234 NN denotes PAI
T6509 8234-8235 HYPH denotes -
T6510 8235-8236 CD denotes 1
T6511 8237-8238 -LRB- denotes (
T6513 8238-8246 NNP denotes American
T6512 8247-8258 NNP denotes Diagnostica
T6514 8258-8259 -RRB- denotes )
T6515 8260-8262 IN denotes as
T6516 8263-8266 DT denotes the
T6518 8267-8274 NN denotes capture
T6517 8275-8283 NN denotes antibody
T6519 8284-8287 CC denotes and
T6520 8288-8293 NN denotes mouse
T6521 8294-8297 NN denotes PAI
T6522 8297-8298 HYPH denotes -
T6523 8298-8299 CD denotes 1
T6524 8300-8301 -LRB- denotes (
T6526 8301-8309 NNP denotes American
T6525 8310-8321 NNP denotes Diagnostica
T6527 8321-8322 -RRB- denotes )
T6528 8323-8325 IN denotes as
T6529 8326-8329 DT denotes the
T6530 8330-8338 JJ denotes standard
T6531 8339-8340 -LRB- denotes (
T6533 8340-8341 CD denotes 0
T6535 8341-8342 SYM denotes –
T6534 8342-8345 CD denotes 3.5
T6532 8346-8348 NNS denotes ng
T6536 8348-8349 SYM denotes /
T6537 8349-8351 NN denotes mL
T6538 8351-8352 -RRB- denotes )
T6539 8352-8353 . denotes .
T6540 8353-8471 sentence denotes Plg was determined with a chromogenic assay [22] and the fibrinolytic activity determined by fibrin degradation [23].
T6541 8354-8357 NN denotes Plg
T6543 8358-8361 VBD denotes was
T6542 8362-8372 VBN denotes determined
T6544 8373-8377 IN denotes with
T6545 8378-8379 DT denotes a
T6547 8380-8391 JJ denotes chromogenic
T6546 8392-8397 NN denotes assay
T6548 8398-8399 -LRB- denotes [
T6549 8399-8401 CD denotes 22
T6550 8401-8402 -RRB- denotes ]
T6551 8403-8406 CC denotes and
T6552 8407-8410 DT denotes the
T6554 8411-8423 JJ denotes fibrinolytic
T6553 8424-8432 NN denotes activity
T6555 8433-8443 VBN denotes determined
T6556 8444-8446 IN denotes by
T6557 8447-8453 NN denotes fibrin
T6558 8454-8465 NN denotes degradation
T6559 8466-8467 -LRB- denotes [
T6560 8467-8469 CD denotes 23
T6561 8469-8470 -RRB- denotes ]
T6562 8470-8471 . denotes .
T6563 8471-8564 sentence denotes For the negative controls in these assays, plasma from PAI-1 or Plg deficient mice was used.
T6564 8472-8475 IN denotes For
T6566 8476-8479 DT denotes the
T6568 8480-8488 JJ denotes negative
T6567 8489-8497 NNS denotes controls
T6569 8498-8500 IN denotes in
T6570 8501-8506 DT denotes these
T6571 8507-8513 NNS denotes assays
T6572 8513-8515 , denotes ,
T6573 8515-8521 NN denotes plasma
T6574 8522-8526 IN denotes from
T6575 8527-8530 NN denotes PAI
T6577 8530-8531 HYPH denotes -
T6578 8531-8532 CD denotes 1
T6579 8533-8535 CC denotes or
T6580 8536-8539 NN denotes Plg
T6576 8540-8549 JJ denotes deficient
T6581 8550-8554 NNS denotes mice
T6582 8555-8558 VBD denotes was
T6565 8559-8563 VBN denotes used
T6583 8563-8564 . denotes .
T6584 8564-8834 sentence denotes Functionally active mouse α2-antiplasmin was determined with a plasmin capture assay and detection with a mouse antibody (Molecular Innovations, Southfield, MI), and fibrinogen with an ELISA assay with antibodies that recognize mouse fibrinogen (Hyphen BioMed, France).
T6585 8565-8577 RB denotes Functionally
T6586 8578-8584 JJ denotes active
T6588 8585-8590 NN denotes mouse
T6589 8591-8593 NN denotes α2
T6590 8593-8594 HYPH denotes -
T6587 8594-8605 NN denotes antiplasmin
T6592 8606-8609 VBD denotes was
T6591 8610-8620 VBN denotes determined
T6593 8621-8625 IN denotes with
T6594 8626-8627 DT denotes a
T6596 8628-8635 NN denotes plasmin
T6597 8636-8643 NN denotes capture
T6595 8644-8649 NN denotes assay
T6598 8650-8653 CC denotes and
T6599 8654-8663 NN denotes detection
T6600 8664-8668 IN denotes with
T6601 8669-8670 DT denotes a
T6603 8671-8676 NN denotes mouse
T6602 8677-8685 NN denotes antibody
T6604 8686-8687 -LRB- denotes (
T6606 8687-8696 NNP denotes Molecular
T6605 8697-8708 NNPS denotes Innovations
T6607 8708-8710 , denotes ,
T6608 8710-8720 NNP denotes Southfield
T6609 8720-8722 , denotes ,
T6610 8722-8724 NNP denotes MI
T6611 8724-8725 -RRB- denotes )
T6612 8725-8727 , denotes ,
T6613 8727-8730 CC denotes and
T6614 8731-8741 NN denotes fibrinogen
T6615 8742-8746 IN denotes with
T6616 8747-8749 DT denotes an
T6618 8750-8755 NN denotes ELISA
T6617 8756-8761 NN denotes assay
T6619 8762-8766 IN denotes with
T6620 8767-8777 NNS denotes antibodies
T6621 8778-8782 WDT denotes that
T6622 8783-8792 VBP denotes recognize
T6623 8793-8798 NN denotes mouse
T6624 8799-8809 NN denotes fibrinogen
T6625 8810-8811 -LRB- denotes (
T6627 8811-8817 NNP denotes Hyphen
T6626 8818-8824 NNP denotes BioMed
T6628 8824-8826 , denotes ,
T6629 8826-8832 NNP denotes France
T6630 8832-8833 -RRB- denotes )
T6631 8833-8834 . denotes .
T6809 8836-8849 JJ denotes Histochemical
T6811 8850-8853 CC denotes and
T6812 8854-8874 NN denotes immunohistochemistry
T6810 8875-8883 NN denotes analysis
T6813 8883-9024 sentence denotes The frozen tails or injured carotids in OCT were sectioned at 5 μm thickness and stained with Masson's Trichrome (HT 15, Sigma Diagnostics).
T6814 8884-8887 DT denotes The
T6816 8888-8894 VBN denotes frozen
T6815 8895-8900 NNS denotes tails
T6818 8901-8903 CC denotes or
T6819 8904-8911 JJ denotes injured
T6820 8912-8920 NNS denotes carotids
T6821 8921-8923 IN denotes in
T6822 8924-8927 NN denotes OCT
T6823 8928-8932 VBD denotes were
T6817 8933-8942 VBN denotes sectioned
T6824 8943-8945 IN denotes at
T6825 8946-8947 CD denotes 5
T6826 8948-8950 NNS denotes μm
T6827 8951-8960 NN denotes thickness
T6828 8961-8964 CC denotes and
T6829 8965-8972 VBD denotes stained
T6830 8973-8977 IN denotes with
T6831 8978-8984 NNP denotes Masson
T6833 8984-8986 POS denotes 's
T6832 8987-8996 NN denotes Trichrome
T6834 8997-8998 -LRB- denotes (
T6836 8998-9000 NN denotes HT
T6837 9001-9003 CD denotes 15
T6838 9003-9005 , denotes ,
T6839 9005-9010 NNP denotes Sigma
T6835 9011-9022 NNP denotes Diagnostics
T6840 9022-9023 -RRB- denotes )
T6841 9023-9024 . denotes .
T6842 9024-9202 sentence denotes For quantitative analysis of collagen area in the tail sections, four sections from 2–3 sites were measured using computer assisted image analysis (Image-Pro Plus, Cybernetics).
T6843 9025-9028 IN denotes For
T6845 9029-9041 JJ denotes quantitative
T6846 9042-9050 NN denotes analysis
T6847 9051-9053 IN denotes of
T6848 9054-9062 NN denotes collagen
T6849 9063-9067 NN denotes area
T6850 9068-9070 IN denotes in
T6851 9071-9074 DT denotes the
T6853 9075-9079 NN denotes tail
T6852 9080-9088 NNS denotes sections
T6854 9088-9090 , denotes ,
T6855 9090-9094 CD denotes four
T6856 9095-9103 NNS denotes sections
T6857 9104-9108 IN denotes from
T6858 9109-9110 CD denotes 2
T6860 9110-9111 SYM denotes –
T6859 9111-9112 CD denotes 3
T6861 9113-9118 NNS denotes sites
T6862 9119-9123 VBD denotes were
T6844 9124-9132 VBN denotes measured
T6863 9133-9138 VBG denotes using
T6864 9139-9147 NN denotes computer
T6865 9148-9156 VBN denotes assisted
T6867 9157-9162 NN denotes image
T6866 9163-9171 NN denotes analysis
T6868 9172-9173 -LRB- denotes (
T6870 9173-9178 NNP denotes Image
T6872 9178-9179 HYPH denotes -
T6873 9179-9182 NNP denotes Pro
T6871 9183-9187 NNP denotes Plus
T6874 9187-9189 , denotes ,
T6869 9189-9200 NNP denotes Cybernetics
T6875 9200-9201 -RRB- denotes )
T6876 9201-9202 . denotes .
T6877 9202-9363 sentence denotes For the area determination of the injured carotid lumen, 3–4 sections from different sites approximately 100 μm apart were analyzed and averaged for each mouse.
T6878 9203-9206 IN denotes For
T6880 9207-9210 DT denotes the
T6882 9211-9215 NN denotes area
T6881 9216-9229 NN denotes determination
T6883 9230-9232 IN denotes of
T6884 9233-9236 DT denotes the
T6886 9237-9244 JJ denotes injured
T6887 9245-9252 NN denotes carotid
T6885 9253-9258 NN denotes lumen
T6888 9258-9260 , denotes ,
T6889 9260-9261 CD denotes 3
T6891 9261-9262 SYM denotes –
T6890 9262-9263 CD denotes 4
T6892 9264-9272 NNS denotes sections
T6893 9273-9277 IN denotes from
T6894 9278-9287 JJ denotes different
T6895 9288-9293 NNS denotes sites
T6896 9294-9307 RB denotes approximately
T6897 9308-9311 CD denotes 100
T6898 9312-9314 NNS denotes μm
T6899 9315-9320 RB denotes apart
T6900 9321-9325 VBD denotes were
T6879 9326-9334 VBN denotes analyzed
T6901 9335-9338 CC denotes and
T6902 9339-9347 VBN denotes averaged
T6903 9348-9351 IN denotes for
T6904 9352-9356 DT denotes each
T6905 9357-9362 NN denotes mouse
T6906 9362-9363 . denotes .
T7165 9365-9375 NN denotes Statistics
T7166 9375-9409 sentence denotes Data are presented as mean ± SEM.
T7167 9376-9380 NNS denotes Data
T7169 9381-9384 VBP denotes are
T7168 9385-9394 VBN denotes presented
T7170 9395-9397 IN denotes as
T7171 9398-9402 NN denotes mean
T7173 9403-9404 SYM denotes ±
T7172 9405-9408 NN denotes SEM
T7174 9408-9409 . denotes .
T7175 9409-9563 sentence denotes The statistical analysis for comparisons between A/J and B6 mice and between wild-type (WT) and Plg-/- littermates was compared with a two-tailed t-test.
T7176 9410-9413 DT denotes The
T7178 9414-9425 JJ denotes statistical
T7177 9426-9434 NN denotes analysis
T7180 9435-9438 IN denotes for
T7181 9439-9450 NNS denotes comparisons
T7182 9451-9458 IN denotes between
T7183 9459-9460 NN denotes A
T7185 9460-9461 HYPH denotes /
T7184 9461-9462 NN denotes J
T7187 9463-9466 CC denotes and
T7188 9467-9469 NN denotes B6
T7186 9470-9474 NNS denotes mice
T7189 9475-9478 CC denotes and
T7190 9479-9486 IN denotes between
T7191 9487-9491 JJ denotes wild
T7193 9491-9492 HYPH denotes -
T7192 9492-9496 NN denotes type
T7195 9497-9498 -LRB- denotes (
T7196 9498-9500 NN denotes WT
T7197 9500-9501 -RRB- denotes )
T7198 9502-9505 CC denotes and
T7199 9506-9509 NN denotes Plg
T7200 9509-9510 SYM denotes -
T7201 9510-9511 HYPH denotes /
T7202 9511-9512 SYM denotes -
T7194 9513-9524 NNS denotes littermates
T7203 9525-9528 VBD denotes was
T7179 9529-9537 VBN denotes compared
T7204 9538-9542 IN denotes with
T7205 9543-9544 DT denotes a
T7207 9545-9548 CD denotes two
T7209 9548-9549 HYPH denotes -
T7208 9549-9555 VBN denotes tailed
T7210 9556-9557 NN denotes t
T7211 9557-9558 HYPH denotes -
T7206 9558-9562 NN denotes test
T7212 9562-9563 . denotes .
T7213 9563-9671 sentence denotes Differences among B6, Lepob, PAI-1-/- mice were determined by a one-way ANOVA and a Newman-Keuls post-test.
T7214 9564-9575 NNS denotes Differences
T7216 9576-9581 IN denotes among
T7217 9582-9584 NN denotes B6
T7219 9584-9586 , denotes ,
T7220 9586-9591 NN denotes Lepob
T7221 9591-9593 , denotes ,
T7222 9593-9596 NN denotes PAI
T7223 9596-9597 HYPH denotes -
T7224 9597-9598 CD denotes 1
T7225 9598-9599 SYM denotes -
T7226 9599-9600 HYPH denotes /
T7227 9600-9601 SYM denotes -
T7218 9602-9606 NNS denotes mice
T7228 9607-9611 VBD denotes were
T7215 9612-9622 VBN denotes determined
T7229 9623-9625 IN denotes by
T7230 9626-9627 DT denotes a
T7232 9628-9631 CD denotes one
T7234 9631-9632 HYPH denotes -
T7233 9632-9635 NN denotes way
T7231 9636-9641 NN denotes ANOVA
T7235 9642-9645 CC denotes and
T7236 9646-9647 DT denotes a
T7238 9648-9654 NNP denotes Newman
T7240 9654-9655 HYPH denotes -
T7239 9655-9660 NNP denotes Keuls
T7237 9661-9670 NN denotes post-test
T7241 9670-9671 . denotes .
T7242 9671-9719 sentence denotes A value of P < 0.05 was considered significant.
T7243 9672-9673 DT denotes A
T7244 9674-9679 NN denotes value
T7246 9680-9682 IN denotes of
T7247 9683-9684 NN denotes P
T7248 9685-9686 SYM denotes <
T7249 9687-9691 CD denotes 0.05
T7250 9692-9695 VBD denotes was
T7245 9696-9706 VBN denotes considered
T7251 9707-9718 JJ denotes significant
T7252 9718-9719 . denotes .
T7253 9719-9970 sentence denotes The statistical analysis for comparisons between B6 mice and CSS were determined with two-tail t-tests and the level of the significant P-values (see figure legends) determined with a Bonferroni correction to account for multihypothesis testing [13].
T7254 9720-9723 DT denotes The
T7256 9724-9735 JJ denotes statistical
T7255 9736-9744 NN denotes analysis
T7258 9745-9748 IN denotes for
T7259 9749-9760 NNS denotes comparisons
T7260 9761-9768 IN denotes between
T7261 9769-9771 NN denotes B6
T7262 9772-9776 NNS denotes mice
T7263 9777-9780 CC denotes and
T7264 9781-9784 NN denotes CSS
T7265 9785-9789 VBD denotes were
T7257 9790-9800 VBN denotes determined
T7266 9801-9805 IN denotes with
T7267 9806-9809 CD denotes two
T7269 9809-9810 HYPH denotes -
T7268 9810-9814 NN denotes tail
T7271 9815-9816 NN denotes t
T7272 9816-9817 HYPH denotes -
T7270 9817-9822 NNS denotes tests
T7273 9823-9826 CC denotes and
T7274 9827-9830 DT denotes the
T7275 9831-9836 NN denotes level
T7277 9837-9839 IN denotes of
T7278 9840-9843 DT denotes the
T7280 9844-9855 JJ denotes significant
T7281 9856-9857 NN denotes P
T7282 9857-9858 HYPH denotes -
T7279 9858-9864 NNS denotes values
T7283 9865-9866 -LRB- denotes (
T7284 9866-9869 VB denotes see
T7285 9870-9876 NN denotes figure
T7286 9877-9884 NNS denotes legends
T7287 9884-9885 -RRB- denotes )
T7276 9886-9896 VBN denotes determined
T7288 9897-9901 IN denotes with
T7289 9902-9903 DT denotes a
T7291 9904-9914 NNP denotes Bonferroni
T7290 9915-9925 NN denotes correction
T7292 9926-9928 TO denotes to
T7293 9929-9936 VB denotes account
T7294 9937-9940 IN denotes for
T7295 9941-9956 NN denotes multihypothesis
T7296 9957-9964 NN denotes testing
T7297 9965-9966 -LRB- denotes [
T7298 9966-9968 CD denotes 13
T7299 9968-9969 -RRB- denotes ]
T7300 9969-9970 . denotes .
T8036 9981-9987 JJ denotes Marked
T8037 9988-9999 NNS denotes differences
T8038 10000-10002 IN denotes in
T8039 10003-10011 JJ denotes arterial
T8040 10012-10020 NN denotes thrombus
T8041 10021-10030 NN denotes formation
T8042 10031-10033 IN denotes in
T8043 10034-10036 NN denotes B6
T8045 10037-10040 CC denotes and
T8046 10041-10042 NN denotes A
T8048 10042-10043 HYPH denotes /
T8047 10043-10044 NN denotes J
T8044 10045-10049 NNS denotes mice
T8049 10049-10235 sentence denotes The FeCl3 cartoid artery injury model [24], a well-characterized arterial thrombosis model, was used to induce an occlusive thrombus in the B6 and A/J mouse strains under investigation.
T8050 10050-10053 DT denotes The
T8052 10054-10059 NN denotes FeCl3
T8053 10060-10067 JJ denotes cartoid
T8054 10068-10074 NN denotes artery
T8055 10075-10081 NN denotes injury
T8051 10082-10087 NN denotes model
T8057 10088-10089 -LRB- denotes [
T8058 10089-10091 CD denotes 24
T8059 10091-10092 -RRB- denotes ]
T8060 10092-10094 , denotes ,
T8061 10094-10095 DT denotes a
T8063 10096-10100 JJ denotes well
T8065 10100-10101 HYPH denotes -
T8064 10101-10114 VBN denotes characterized
T8066 10115-10123 JJ denotes arterial
T8067 10124-10134 NN denotes thrombosis
T8062 10135-10140 NN denotes model
T8068 10140-10142 , denotes ,
T8069 10142-10145 VBD denotes was
T8056 10146-10150 VBN denotes used
T8070 10151-10153 TO denotes to
T8071 10154-10160 VB denotes induce
T8072 10161-10163 DT denotes an
T8074 10164-10173 JJ denotes occlusive
T8073 10174-10182 NN denotes thrombus
T8075 10183-10185 IN denotes in
T8076 10186-10189 DT denotes the
T8078 10190-10192 NN denotes B6
T8079 10193-10196 CC denotes and
T8080 10197-10198 NN denotes A
T8082 10198-10199 HYPH denotes /
T8081 10199-10200 NN denotes J
T8083 10201-10206 NN denotes mouse
T8077 10207-10214 NNS denotes strains
T8084 10215-10220 IN denotes under
T8085 10221-10234 NN denotes investigation
T8086 10234-10235 . denotes .
T8087 10235-10346 sentence denotes A marked difference in arterial thrombus occlusion time was found between the B6 and the A/J mice (Figure 1A).
T8088 10236-10237 DT denotes A
T8090 10238-10244 JJ denotes marked
T8089 10245-10255 NN denotes difference
T8092 10256-10258 IN denotes in
T8093 10259-10267 JJ denotes arterial
T8094 10268-10276 NN denotes thrombus
T8095 10277-10286 NN denotes occlusion
T8096 10287-10291 NN denotes time
T8097 10292-10295 VBD denotes was
T8091 10296-10301 VBN denotes found
T8098 10302-10309 IN denotes between
T8099 10310-10313 DT denotes the
T8100 10314-10316 NN denotes B6
T8101 10317-10320 CC denotes and
T8102 10321-10324 DT denotes the
T8104 10325-10326 NN denotes A
T8105 10326-10327 HYPH denotes /
T8103 10327-10328 NN denotes J
T8106 10329-10333 NNS denotes mice
T8107 10334-10335 -LRB- denotes (
T8109 10335-10341 NN denotes Figure
T8108 10342-10344 NN denotes 1A
T8110 10344-10345 -RRB- denotes )
T8111 10345-10346 . denotes .
T8112 10346-10419 sentence denotes The occlusion time in the A/J mice was 2-fold less than for the B6 mice.
T8113 10347-10350 DT denotes The
T8115 10351-10360 NN denotes occlusion
T8114 10361-10365 NN denotes time
T8117 10366-10368 IN denotes in
T8118 10369-10372 DT denotes the
T8120 10373-10374 NN denotes A
T8122 10374-10375 HYPH denotes /
T8121 10375-10376 NN denotes J
T8119 10377-10381 NNS denotes mice
T8116 10382-10385 VBD denotes was
T8123 10386-10392 RB denotes 2-fold
T8124 10393-10397 JJR denotes less
T8125 10398-10402 IN denotes than
T8126 10403-10406 IN denotes for
T8127 10407-10410 DT denotes the
T8129 10411-10413 NN denotes B6
T8128 10414-10418 NNS denotes mice
T8130 10418-10419 . denotes .
T8131 10419-10573 sentence denotes A 5% dose of FeCl3 was tested in the A/J and B6 mice and the occlusion time was lower in the A/J than the B6 mice, the same results as with the 10% dose.
T8132 10420-10421 DT denotes A
T8134 10422-10423 CD denotes 5
T8135 10423-10424 NN denotes %
T8133 10425-10429 NN denotes dose
T8137 10430-10432 IN denotes of
T8138 10433-10438 NN denotes FeCl3
T8139 10439-10442 VBD denotes was
T8136 10443-10449 VBN denotes tested
T8140 10450-10452 IN denotes in
T8141 10453-10456 DT denotes the
T8143 10457-10458 NN denotes A
T8145 10458-10459 HYPH denotes /
T8144 10459-10460 NN denotes J
T8146 10461-10464 CC denotes and
T8147 10465-10467 NN denotes B6
T8142 10468-10472 NNS denotes mice
T8148 10473-10476 CC denotes and
T8149 10477-10480 DT denotes the
T8151 10481-10490 NN denotes occlusion
T8150 10491-10495 NN denotes time
T8152 10496-10499 VBD denotes was
T8153 10500-10505 JJR denotes lower
T8154 10506-10508 IN denotes in
T8155 10509-10512 DT denotes the
T8157 10513-10514 NN denotes A
T8158 10514-10515 HYPH denotes /
T8156 10515-10516 NN denotes J
T8159 10517-10521 IN denotes than
T8160 10522-10525 DT denotes the
T8161 10526-10528 NN denotes B6
T8162 10529-10533 NNS denotes mice
T8163 10533-10535 , denotes ,
T8164 10535-10538 DT denotes the
T8166 10539-10543 JJ denotes same
T8165 10544-10551 NNS denotes results
T8167 10552-10554 IN denotes as
T8168 10555-10559 IN denotes with
T8169 10560-10563 DT denotes the
T8171 10564-10566 CD denotes 10
T8172 10566-10567 NN denotes %
T8170 10568-10572 NN denotes dose
T8173 10572-10573 . denotes .
T8174 10573-10726 sentence denotes The occlusion time (min for both B6 (15 ± 3, n = 3) and A/J (8 ± 1, n = 3) at 5% were longer than at 10% for B6 (10 ± 1, n = 17 and A/J (5 ± 2, n = 14).
T8175 10574-10577 DT denotes The
T8177 10578-10587 NN denotes occlusion
T8176 10588-10592 NN denotes time
T8179 10593-10594 -LRB- denotes (
T8180 10594-10597 NNS denotes min
T8181 10598-10601 IN denotes for
T8182 10602-10606 CC denotes both
T8183 10607-10609 NN denotes B6
T8184 10610-10611 -LRB- denotes (
T8186 10611-10613 CD denotes 15
T8187 10614-10615 SYM denotes ±
T8185 10616-10617 CD denotes 3
T8188 10617-10619 , denotes ,
T8189 10619-10620 NN denotes n
T8191 10621-10622 SYM denotes =
T8190 10623-10624 CD denotes 3
T8192 10624-10625 -RRB- denotes )
T8193 10626-10629 CC denotes and
T8194 10630-10631 NN denotes A
T8196 10631-10632 HYPH denotes /
T8195 10632-10633 NN denotes J
T8197 10634-10635 -LRB- denotes (
T8199 10635-10636 CD denotes 8
T8200 10637-10638 SYM denotes ±
T8198 10639-10640 CD denotes 1
T8201 10640-10642 , denotes ,
T8202 10642-10643 NN denotes n
T8204 10644-10645 SYM denotes =
T8203 10646-10647 CD denotes 3
T8205 10647-10648 -RRB- denotes )
T8206 10649-10651 IN denotes at
T8207 10652-10653 CD denotes 5
T8208 10653-10654 NN denotes %
T8178 10655-10659 VBD denotes were
T8209 10660-10666 JJR denotes longer
T8210 10667-10671 IN denotes than
T8211 10672-10674 IN denotes at
T8212 10675-10677 CD denotes 10
T8213 10677-10678 NN denotes %
T8214 10679-10682 IN denotes for
T8215 10683-10685 NN denotes B6
T8216 10686-10687 -LRB- denotes (
T8218 10687-10689 CD denotes 10
T8219 10690-10691 SYM denotes ±
T8217 10692-10693 CD denotes 1
T8220 10693-10695 , denotes ,
T8221 10695-10696 NN denotes n
T8223 10697-10698 SYM denotes =
T8222 10699-10701 CD denotes 17
T8224 10702-10705 CC denotes and
T8225 10706-10707 NN denotes A
T8227 10707-10708 HYPH denotes /
T8226 10708-10709 NN denotes J
T8228 10710-10711 -LRB- denotes (
T8230 10711-10712 CD denotes 5
T8231 10713-10714 SYM denotes ±
T8229 10715-10716 CD denotes 2
T8232 10716-10718 , denotes ,
T8233 10718-10719 NN denotes n
T8235 10720-10721 SYM denotes =
T8234 10722-10724 CD denotes 14
T8236 10724-10725 -RRB- denotes )
T8237 10725-10726 . denotes .
T8238 10726-10995 sentence denotes The curves of blood flow after FeCl3 application indicated a pattern with a gradual decrease before occlusion for the B6 mice (Figure 1B), but for the A/J mice the blood flow decreased abruptly to zero (Figure 1C), demonstrating a marked difference from the B6 strain.
T8239 10727-10730 DT denotes The
T8240 10731-10737 NNS denotes curves
T8242 10738-10740 IN denotes of
T8243 10741-10746 NN denotes blood
T8244 10747-10751 NN denotes flow
T8245 10752-10757 IN denotes after
T8246 10758-10763 NN denotes FeCl3
T8247 10764-10775 NN denotes application
T8241 10776-10785 VBD denotes indicated
T8248 10786-10787 DT denotes a
T8249 10788-10795 NN denotes pattern
T8250 10796-10800 IN denotes with
T8251 10801-10802 DT denotes a
T8253 10803-10810 JJ denotes gradual
T8252 10811-10819 NN denotes decrease
T8254 10820-10826 IN denotes before
T8255 10827-10836 NN denotes occlusion
T8256 10837-10840 IN denotes for
T8257 10841-10844 DT denotes the
T8259 10845-10847 NN denotes B6
T8258 10848-10852 NNS denotes mice
T8260 10853-10854 -LRB- denotes (
T8262 10854-10860 NN denotes Figure
T8261 10861-10863 NN denotes 1B
T8263 10863-10864 -RRB- denotes )
T8264 10864-10866 , denotes ,
T8265 10866-10869 CC denotes but
T8266 10870-10873 IN denotes for
T8268 10874-10877 DT denotes the
T8270 10878-10879 NN denotes A
T8272 10879-10880 HYPH denotes /
T8271 10880-10881 NN denotes J
T8269 10882-10886 NNS denotes mice
T8273 10887-10890 DT denotes the
T8275 10891-10896 NN denotes blood
T8274 10897-10901 NN denotes flow
T8267 10902-10911 VBD denotes decreased
T8276 10912-10920 RB denotes abruptly
T8277 10921-10923 IN denotes to
T8278 10924-10928 CD denotes zero
T8279 10929-10930 -LRB- denotes (
T8281 10930-10936 NN denotes Figure
T8280 10937-10939 NN denotes 1C
T8282 10939-10940 -RRB- denotes )
T8283 10940-10942 , denotes ,
T8284 10942-10955 VBG denotes demonstrating
T8285 10956-10957 DT denotes a
T8287 10958-10964 JJ denotes marked
T8286 10965-10975 NN denotes difference
T8288 10976-10980 IN denotes from
T8289 10981-10984 DT denotes the
T8291 10985-10987 NN denotes B6
T8290 10988-10994 NN denotes strain
T8292 10994-10995 . denotes .
T8293 10995-11086 sentence denotes The mean occlusion times were significantly different between the two strains (Figure 1A).
T8294 10996-10999 DT denotes The
T8296 11000-11004 JJ denotes mean
T8297 11005-11014 NN denotes occlusion
T8295 11015-11020 NNS denotes times
T8298 11021-11025 VBD denotes were
T8299 11026-11039 RB denotes significantly
T8300 11040-11049 JJ denotes different
T8301 11050-11057 IN denotes between
T8302 11058-11061 DT denotes the
T8304 11062-11065 CD denotes two
T8303 11066-11073 NNS denotes strains
T8305 11074-11075 -LRB- denotes (
T8307 11075-11081 NN denotes Figure
T8306 11082-11084 NN denotes 1A
T8308 11084-11085 -RRB- denotes )
T8309 11085-11086 . denotes .
T8310 11086-11156 sentence denotes The size of the carotids in the two strains was noticeably different.
T8311 11087-11090 DT denotes The
T8312 11091-11095 NN denotes size
T8314 11096-11098 IN denotes of
T8315 11099-11102 DT denotes the
T8316 11103-11111 NNS denotes carotids
T8317 11112-11114 IN denotes in
T8318 11115-11118 DT denotes the
T8320 11119-11122 CD denotes two
T8319 11123-11130 NNS denotes strains
T8313 11131-11134 VBD denotes was
T8321 11135-11145 RB denotes noticeably
T8322 11146-11155 JJ denotes different
T8323 11155-11156 . denotes .
T8324 11156-11287 sentence denotes The area (mm2) of the lumen (0.066 ± 0.007, n = 6) was significantly less in the A/J mice than for B6 mice (0.128 ± 0.007, n = 6).
T8325 11157-11160 DT denotes The
T8326 11161-11165 NN denotes area
T8328 11166-11167 -LRB- denotes (
T8329 11167-11170 NN denotes mm2
T8330 11170-11171 -RRB- denotes )
T8331 11172-11174 IN denotes of
T8332 11175-11178 DT denotes the
T8333 11179-11184 NN denotes lumen
T8334 11185-11186 -LRB- denotes (
T8336 11186-11191 CD denotes 0.066
T8337 11192-11193 SYM denotes ±
T8335 11194-11199 CD denotes 0.007
T8338 11199-11201 , denotes ,
T8339 11201-11202 NN denotes n
T8341 11203-11204 SYM denotes =
T8340 11205-11206 CD denotes 6
T8342 11206-11207 -RRB- denotes )
T8327 11208-11211 VBD denotes was
T8343 11212-11225 RB denotes significantly
T8344 11226-11230 JJR denotes less
T8345 11231-11233 IN denotes in
T8346 11234-11237 DT denotes the
T8348 11238-11239 NN denotes A
T8350 11239-11240 SYM denotes /
T8349 11240-11241 NN denotes J
T8347 11242-11246 NNS denotes mice
T8351 11247-11251 IN denotes than
T8352 11252-11255 IN denotes for
T8353 11256-11258 NN denotes B6
T8354 11259-11263 NNS denotes mice
T8355 11264-11265 -LRB- denotes (
T8357 11265-11270 CD denotes 0.128
T8358 11271-11272 SYM denotes ±
T8356 11273-11278 CD denotes 0.007
T8359 11278-11280 , denotes ,
T8360 11280-11281 NN denotes n
T8362 11282-11283 SYM denotes =
T8361 11284-11285 CD denotes 6
T8363 11285-11286 -RRB- denotes )
T8364 11286-11287 . denotes .
T8365 11287-11400 sentence denotes However, the ratio of the thrombus to lumen was similar for A/J (0.63 ± 0.03) compared to B6 mice (0.67 ± 0.09).
T8366 11288-11295 RB denotes However
T8368 11295-11297 , denotes ,
T8369 11297-11300 DT denotes the
T8370 11301-11306 NN denotes ratio
T8371 11307-11309 IN denotes of
T8372 11310-11313 DT denotes the
T8373 11314-11322 NN denotes thrombus
T8374 11323-11325 IN denotes to
T8375 11326-11331 NN denotes lumen
T8367 11332-11335 VBD denotes was
T8376 11336-11343 JJ denotes similar
T8377 11344-11347 IN denotes for
T8378 11348-11349 NN denotes A
T8380 11349-11350 HYPH denotes /
T8379 11350-11351 NN denotes J
T8381 11352-11353 -LRB- denotes (
T8383 11353-11357 CD denotes 0.63
T8384 11358-11359 SYM denotes ±
T8382 11360-11364 CD denotes 0.03
T8385 11364-11365 -RRB- denotes )
T8386 11366-11374 VBN denotes compared
T8387 11375-11377 IN denotes to
T8388 11378-11380 NN denotes B6
T8389 11381-11385 NNS denotes mice
T8390 11386-11387 -LRB- denotes (
T8392 11387-11391 CD denotes 0.67
T8393 11392-11393 SYM denotes ±
T8391 11394-11398 CD denotes 0.09
T8394 11398-11399 -RRB- denotes )
T8395 11399-11400 . denotes .
T8396 11400-11491 sentence denotes Calculated sheer stress rates [25] were 14% less in the A/J mice when compared to B6 mice.
T8397 11401-11411 VBN denotes Calculated
T8399 11412-11417 NN denotes sheer
T8400 11418-11424 NN denotes stress
T8398 11425-11430 NNS denotes rates
T8402 11431-11432 -LRB- denotes [
T8403 11432-11434 CD denotes 25
T8404 11434-11435 -RRB- denotes ]
T8401 11436-11440 VBD denotes were
T8405 11441-11443 CD denotes 14
T8406 11443-11444 NN denotes %
T8407 11445-11449 JJR denotes less
T8408 11450-11452 IN denotes in
T8409 11453-11456 DT denotes the
T8411 11457-11458 NN denotes A
T8413 11458-11459 HYPH denotes /
T8412 11459-11460 NN denotes J
T8410 11461-11465 NNS denotes mice
T8414 11466-11470 WRB denotes when
T8415 11471-11479 VBN denotes compared
T8416 11480-11482 IN denotes to
T8417 11483-11485 NN denotes B6
T8418 11486-11490 NNS denotes mice
T8419 11490-11491 . denotes .
T20771 11502-11510 JJ denotes Arterial
T20772 11511-11520 NN denotes occlusion
T20773 11521-11525 NN denotes time
T20774 11526-11528 IN denotes in
T20775 11529-11531 NN denotes B6
T20777 11532-11535 CC denotes and
T20778 11536-11537 NN denotes A
T20780 11537-11538 HYPH denotes /
T20779 11538-11539 NN denotes J
T20776 11540-11544 NNS denotes mice
T20781 11544-11545 . denotes .
T20782 11545-11616 sentence denotes Panels A and B are representative occlusion curves from each genotype.
T20783 11546-11552 NNS denotes Panels
T20784 11553-11554 NN denotes A
T20786 11555-11558 CC denotes and
T20787 11559-11560 NN denotes B
T20785 11561-11564 VBP denotes are
T20788 11565-11579 JJ denotes representative
T20790 11580-11589 NN denotes occlusion
T20789 11590-11596 NNS denotes curves
T20791 11597-11601 IN denotes from
T20792 11602-11606 DT denotes each
T20793 11607-11615 NN denotes genotype
T20794 11615-11616 . denotes .
T20795 11616-11692 sentence denotes Red arrows indicate duration of ferric chloride application to the carotid.
T20796 11617-11620 JJ denotes Red
T20797 11621-11627 NNS denotes arrows
T20798 11628-11636 VBP denotes indicate
T20799 11637-11645 NN denotes duration
T20800 11646-11648 IN denotes of
T20801 11649-11655 JJ denotes ferric
T20802 11656-11664 NN denotes chloride
T20803 11665-11676 NN denotes application
T20804 11677-11679 IN denotes to
T20805 11680-11683 DT denotes the
T20806 11684-11691 NN denotes carotid
T20807 11691-11692 . denotes .
T20808 11692-11729 sentence denotes Panel A: B6 mice, Panel B: A/J mice.
T20809 11693-11698 NN denotes Panel
T20810 11699-11700 NN denotes A
T20811 11700-11702 : denotes :
T20812 11702-11704 NN denotes B6
T20813 11705-11709 NNS denotes mice
T20814 11709-11711 , denotes ,
T20815 11711-11716 NN denotes Panel
T20816 11717-11718 NN denotes B
T20817 11718-11720 : denotes :
T20818 11720-11721 NN denotes A
T20820 11721-11722 HYPH denotes /
T20819 11722-11723 NN denotes J
T20821 11724-11728 NNS denotes mice
T20822 11728-11729 . denotes .
T20823 11729-11802 sentence denotes Panel C: Arterial occlusion time, mean ± SEM of 14–17 mice per genotype.
T20824 11730-11735 NN denotes Panel
T20825 11736-11737 NN denotes C
T20826 11737-11739 : denotes :
T20827 11739-11747 JJ denotes Arterial
T20828 11748-11757 NN denotes occlusion
T20829 11758-11762 NN denotes time
T20830 11762-11764 , denotes ,
T20831 11764-11768 NN denotes mean
T20833 11769-11770 SYM denotes ±
T20832 11771-11774 NN denotes SEM
T20834 11775-11777 IN denotes of
T20835 11778-11780 CD denotes 14
T20837 11780-11781 HYPH denotes –
T20836 11781-11783 CD denotes 17
T20838 11784-11788 NNS denotes mice
T20839 11789-11792 IN denotes per
T20840 11793-11801 NN denotes genotype
T20841 11801-11802 . denotes .
T20842 11802-11899 sentence denotes Symbol indicates a significant difference (**P < 0.01) between B6 mice determined with a t-test.
T20843 11803-11809 NN denotes Symbol
T20844 11810-11819 VBZ denotes indicates
T20845 11820-11821 DT denotes a
T20847 11822-11833 JJ denotes significant
T20846 11834-11844 NN denotes difference
T20848 11845-11846 -LRB- denotes (
T20850 11846-11848 SYM denotes **
T20851 11848-11849 NN denotes P
T20852 11850-11851 SYM denotes <
T20849 11852-11856 CD denotes 0.01
T20853 11856-11857 -RRB- denotes )
T20854 11858-11865 IN denotes between
T20855 11866-11868 NN denotes B6
T20856 11869-11873 NNS denotes mice
T20857 11874-11884 VBN denotes determined
T20858 11885-11889 IN denotes with
T20859 11890-11891 DT denotes a
T20861 11892-11893 NN denotes t
T20862 11893-11894 HYPH denotes -
T20860 11894-11898 NN denotes test
T20863 11898-11899 . denotes .
T9400 11901-11907 JJ denotes Marked
T9401 11908-11919 NNS denotes differences
T9402 11920-11922 IN denotes in
T9403 11923-11933 NN denotes rebleeding
T9404 11934-11938 NN denotes time
T9405 11939-11941 IN denotes in
T9406 11942-11944 NN denotes B6
T9408 11945-11948 CC denotes and
T9409 11949-11950 NN denotes A
T9411 11950-11951 HYPH denotes /
T9410 11951-11952 NN denotes J
T9407 11953-11957 NNS denotes mice
T9412 11957-12161 sentence denotes The bleeding time, an indicator of hemostatic activity, was determined after prewarming the tail, clipping a 5 mm segment, placing the tail in warm saline and measuring the time for the bleeding to stop.
T9413 11958-11961 DT denotes The
T9415 11962-11970 NN denotes bleeding
T9414 11971-11975 NN denotes time
T9417 11975-11977 , denotes ,
T9418 11977-11979 DT denotes an
T9419 11980-11989 NN denotes indicator
T9420 11990-11992 IN denotes of
T9421 11993-12003 JJ denotes hemostatic
T9422 12004-12012 NN denotes activity
T9423 12012-12014 , denotes ,
T9424 12014-12017 VBD denotes was
T9416 12018-12028 VBN denotes determined
T9425 12029-12034 IN denotes after
T9426 12035-12045 VBG denotes prewarming
T9427 12046-12049 DT denotes the
T9428 12050-12054 NN denotes tail
T9429 12054-12056 , denotes ,
T9430 12056-12064 VBG denotes clipping
T9431 12065-12066 DT denotes a
T9433 12067-12068 CD denotes 5
T9434 12069-12071 NN denotes mm
T9432 12072-12079 NN denotes segment
T9435 12079-12081 , denotes ,
T9436 12081-12088 VBG denotes placing
T9437 12089-12092 DT denotes the
T9438 12093-12097 NN denotes tail
T9439 12098-12100 IN denotes in
T9440 12101-12105 JJ denotes warm
T9441 12106-12112 NN denotes saline
T9442 12113-12116 CC denotes and
T9443 12117-12126 VBG denotes measuring
T9444 12127-12130 DT denotes the
T9445 12131-12135 NN denotes time
T9446 12136-12139 IN denotes for
T9448 12140-12143 DT denotes the
T9449 12144-12152 NN denotes bleeding
T9450 12153-12155 TO denotes to
T9447 12156-12160 VB denotes stop
T9451 12160-12161 . denotes .
T9452 12161-12274 sentence denotes We found this procedure was consistent and reproducible in different mouse strains and was not gender dependent.
T9453 12162-12164 PRP denotes We
T9454 12165-12170 VBD denotes found
T9455 12171-12175 DT denotes this
T9456 12176-12185 NN denotes procedure
T9457 12186-12189 VBD denotes was
T9458 12190-12200 JJ denotes consistent
T9459 12201-12204 CC denotes and
T9460 12205-12217 JJ denotes reproducible
T9461 12218-12220 IN denotes in
T9462 12221-12230 JJ denotes different
T9464 12231-12236 NN denotes mouse
T9463 12237-12244 NNS denotes strains
T9465 12245-12248 CC denotes and
T9466 12249-12252 VBD denotes was
T9467 12253-12256 RB denotes not
T9468 12257-12263 NN denotes gender
T9469 12264-12273 JJ denotes dependent
T9470 12273-12274 . denotes .
T9471 12274-12351 sentence denotes Bleeding time was not different in A/J mice compared to B6 mice (Figure 2A).
T9472 12275-12283 NN denotes Bleeding
T9473 12284-12288 NN denotes time
T9474 12289-12292 VBD denotes was
T9475 12293-12296 RB denotes not
T9476 12297-12306 JJ denotes different
T9477 12307-12309 IN denotes in
T9478 12310-12311 NN denotes A
T9480 12311-12312 HYPH denotes /
T9479 12312-12313 NN denotes J
T9481 12314-12318 NNS denotes mice
T9482 12319-12327 VBN denotes compared
T9483 12328-12330 IN denotes to
T9484 12331-12333 NN denotes B6
T9485 12334-12338 NNS denotes mice
T9486 12339-12340 -LRB- denotes (
T9488 12340-12346 NN denotes Figure
T9487 12347-12349 NN denotes 2A
T9489 12349-12350 -RRB- denotes )
T9490 12350-12351 . denotes .
T9491 12351-12546 sentence denotes In order to determine if specific pathways were altered in the B6 and A/J strains, mice with known alterations in hemostasis, Lepob mice, or thrombosis, Plg-/- and PAI-/- mice, were also tested.
T9492 12352-12354 IN denotes In
T9494 12355-12360 NN denotes order
T9495 12361-12363 TO denotes to
T9496 12364-12373 VB denotes determine
T9497 12374-12376 IN denotes if
T9499 12377-12385 JJ denotes specific
T9500 12386-12394 NNS denotes pathways
T9501 12395-12399 VBD denotes were
T9498 12400-12407 VBN denotes altered
T9502 12408-12410 IN denotes in
T9503 12411-12414 DT denotes the
T9505 12415-12417 NN denotes B6
T9506 12418-12421 CC denotes and
T9507 12422-12423 NN denotes A
T9509 12423-12424 HYPH denotes /
T9508 12424-12425 NN denotes J
T9504 12426-12433 NNS denotes strains
T9510 12433-12435 , denotes ,
T9511 12435-12439 NNS denotes mice
T9512 12440-12444 IN denotes with
T9513 12445-12450 JJ denotes known
T9514 12451-12462 NNS denotes alterations
T9515 12463-12465 IN denotes in
T9516 12466-12476 NN denotes hemostasis
T9517 12476-12478 , denotes ,
T9518 12478-12483 NN denotes Lepob
T9519 12484-12488 NNS denotes mice
T9520 12488-12490 , denotes ,
T9521 12490-12492 CC denotes or
T9522 12493-12503 NN denotes thrombosis
T9523 12503-12505 , denotes ,
T9524 12505-12508 NN denotes Plg
T9526 12508-12509 SYM denotes -
T9527 12509-12510 HYPH denotes /
T9528 12510-12511 SYM denotes -
T9529 12512-12515 CC denotes and
T9530 12516-12519 NN denotes PAI
T9531 12519-12520 SYM denotes -
T9532 12520-12521 HYPH denotes /
T9533 12521-12522 SYM denotes -
T9525 12523-12527 NNS denotes mice
T9534 12527-12529 , denotes ,
T9535 12529-12533 VBD denotes were
T9536 12534-12538 RB denotes also
T9493 12539-12545 VBN denotes tested
T9537 12545-12546 . denotes .
T9538 12546-12658 sentence denotes The Lepob mice have impaired platelet aggregation [26] and were evaluated as a reference for platelet function.
T9539 12547-12550 DT denotes The
T9541 12551-12556 NN denotes Lepob
T9540 12557-12561 NNS denotes mice
T9542 12562-12566 VBP denotes have
T9543 12567-12575 VBN denotes impaired
T9545 12576-12584 NN denotes platelet
T9544 12585-12596 NN denotes aggregation
T9546 12597-12598 -LRB- denotes [
T9547 12598-12600 CD denotes 26
T9548 12600-12601 -RRB- denotes ]
T9549 12602-12605 CC denotes and
T9550 12606-12610 VBD denotes were
T9551 12611-12620 VBN denotes evaluated
T9552 12621-12623 IN denotes as
T9553 12624-12625 DT denotes a
T9554 12626-12635 NN denotes reference
T9555 12636-12639 IN denotes for
T9556 12640-12648 NN denotes platelet
T9557 12649-12657 NN denotes function
T9558 12657-12658 . denotes .
T9559 12658-12762 sentence denotes In the Lepob mice (Figure 2A) there was nearly a 10-fold increase in bleeding time compared to B6 mice.
T9560 12659-12661 IN denotes In
T9562 12662-12665 DT denotes the
T9564 12666-12671 NN denotes Lepob
T9563 12672-12676 NNS denotes mice
T9565 12677-12678 -LRB- denotes (
T9567 12678-12684 NN denotes Figure
T9566 12685-12687 NN denotes 2A
T9568 12687-12688 -RRB- denotes )
T9569 12689-12694 EX denotes there
T9561 12695-12698 VBD denotes was
T9570 12699-12705 RB denotes nearly
T9572 12706-12707 DT denotes a
T9573 12708-12715 RB denotes 10-fold
T9571 12716-12724 NN denotes increase
T9574 12725-12727 IN denotes in
T9575 12728-12736 NN denotes bleeding
T9576 12737-12741 NN denotes time
T9577 12742-12750 VBN denotes compared
T9578 12751-12753 IN denotes to
T9579 12754-12756 NN denotes B6
T9580 12757-12761 NNS denotes mice
T9581 12761-12762 . denotes .
T9582 12762-12881 sentence denotes Bleeding time was also significantly (P = 0.0001) increased by 66% in the Plg-/- mice compared to WT mice littermates.
T9583 12763-12771 NN denotes Bleeding
T9584 12772-12776 NN denotes time
T9586 12777-12780 VBD denotes was
T9587 12781-12785 RB denotes also
T9588 12786-12799 RB denotes significantly
T9589 12800-12801 -LRB- denotes (
T9591 12801-12802 NN denotes P
T9592 12803-12804 SYM denotes =
T9590 12805-12811 CD denotes 0.0001
T9593 12811-12812 -RRB- denotes )
T9585 12813-12822 VBN denotes increased
T9594 12823-12825 IN denotes by
T9595 12826-12828 CD denotes 66
T9596 12828-12829 NN denotes %
T9597 12830-12832 IN denotes in
T9598 12833-12836 DT denotes the
T9600 12837-12840 NN denotes Plg
T9601 12840-12841 SYM denotes -
T9602 12841-12842 HYPH denotes /
T9603 12842-12843 SYM denotes -
T9599 12844-12848 NNS denotes mice
T9604 12849-12857 VBN denotes compared
T9605 12858-12860 IN denotes to
T9606 12861-12863 NN denotes WT
T9608 12864-12868 NNS denotes mice
T9607 12869-12880 NNS denotes littermates
T9609 12880-12881 . denotes .
T9610 12881-12951 sentence denotes Bleeding time was not different in PAI-1-/- mice compared to B6 mice.
T9611 12882-12890 NN denotes Bleeding
T9612 12891-12895 NN denotes time
T9613 12896-12899 VBD denotes was
T9614 12900-12903 RB denotes not
T9615 12904-12913 JJ denotes different
T9616 12914-12916 IN denotes in
T9617 12917-12920 NN denotes PAI
T9619 12920-12921 HYPH denotes -
T9620 12921-12922 CD denotes 1
T9621 12922-12923 SYM denotes -
T9622 12923-12924 HYPH denotes /
T9623 12924-12925 SYM denotes -
T9618 12926-12930 NNS denotes mice
T9624 12931-12939 VBN denotes compared
T9625 12940-12942 IN denotes to
T9626 12943-12945 NN denotes B6
T9627 12946-12950 NNS denotes mice
T9628 12950-12951 . denotes .
T9629 12951-13184 sentence denotes In contrast to the Lepob mice with a platelet defect and 10-fold increase in bleeding time, there was no difference in the bleeding time between B6 and A/J mice and suggested platelet aggregation is not altered in these two strains.
T9630 12952-12954 IN denotes In
T9632 12955-12963 NN denotes contrast
T9633 12964-12966 IN denotes to
T9634 12967-12970 DT denotes the
T9636 12971-12976 NN denotes Lepob
T9635 12977-12981 NNS denotes mice
T9637 12982-12986 IN denotes with
T9638 12987-12988 DT denotes a
T9640 12989-12997 NN denotes platelet
T9639 12998-13004 NN denotes defect
T9641 13005-13008 CC denotes and
T9642 13009-13016 RB denotes 10-fold
T9643 13017-13025 NN denotes increase
T9644 13026-13028 IN denotes in
T9645 13029-13037 NN denotes bleeding
T9646 13038-13042 NN denotes time
T9647 13042-13044 , denotes ,
T9648 13044-13049 EX denotes there
T9631 13050-13053 VBD denotes was
T9649 13054-13056 DT denotes no
T9650 13057-13067 NN denotes difference
T9651 13068-13070 IN denotes in
T9652 13071-13074 DT denotes the
T9654 13075-13083 NN denotes bleeding
T9653 13084-13088 NN denotes time
T9655 13089-13096 IN denotes between
T9656 13097-13099 NN denotes B6
T9658 13100-13103 CC denotes and
T9659 13104-13105 NN denotes A
T9661 13105-13106 HYPH denotes /
T9660 13106-13107 NN denotes J
T9657 13108-13112 NNS denotes mice
T9662 13113-13116 CC denotes and
T9663 13117-13126 VBD denotes suggested
T9664 13127-13135 NN denotes platelet
T9665 13136-13147 NN denotes aggregation
T9667 13148-13150 VBZ denotes is
T9668 13151-13154 RB denotes not
T9666 13155-13162 VBN denotes altered
T9669 13163-13165 IN denotes in
T9670 13166-13171 DT denotes these
T9672 13172-13175 CD denotes two
T9671 13176-13183 NNS denotes strains
T9673 13183-13184 . denotes .
T9674 13184-13893 sentence denotes Figure 2 Bleeding and rebleeding time in B6, A/J, Lepob, Plg-/- and PAI-1-/- mice. Panel A, B: Bleeding time (seconds) and Panel C, D: Rebleeding time (seconds). To determine statistical differences, values from B6 and A/J and from WT and Plg-/- littermates were compared with a t-test, and values from B6, PAI-1-/- and Lepob were compared by a one-way ANOVA and a Newman-Keuls post-test. Symbols indicate a significant difference (*P < 0.05, **P < 0.01, ***P < 0.001) between B6 or WT mice. Values are the mean ± SEM of 10–34 mice per genotype. Rebleeding time, an indicator of thrombus stability, was measured as the time between the cessation of bleeding and the start of the second bleeding (Figure 2B).
T21152 13195-13203 NN denotes Bleeding
T21154 13204-13207 CC denotes and
T21155 13208-13218 NN denotes rebleeding
T21153 13219-13223 NN denotes time
T21156 13224-13226 IN denotes in
T21157 13227-13229 NN denotes B6
T21159 13229-13231 , denotes ,
T21160 13231-13232 NN denotes A
T21162 13232-13233 HYPH denotes /
T21161 13233-13234 NN denotes J
T21163 13234-13236 , denotes ,
T21164 13236-13241 NNP denotes Lepob
T21165 13241-13243 , denotes ,
T21166 13243-13246 NN denotes Plg
T21167 13246-13247 SYM denotes -
T21168 13247-13248 HYPH denotes /
T21169 13248-13249 SYM denotes -
T21170 13250-13253 CC denotes and
T21171 13254-13257 NN denotes PAI
T21172 13257-13258 HYPH denotes -
T21173 13258-13259 CD denotes 1
T21174 13259-13260 SYM denotes -
T21175 13260-13261 HYPH denotes /
T21176 13261-13262 SYM denotes -
T21158 13263-13267 NNS denotes mice
T21177 13267-13268 . denotes .
T21178 13268-13347 sentence denotes Panel A, B: Bleeding time (seconds) and Panel C, D: Rebleeding time (seconds).
T21179 13269-13274 NN denotes Panel
T21181 13275-13276 NN denotes A
T21182 13276-13278 , denotes ,
T21180 13278-13279 NN denotes B
T21184 13279-13281 : denotes :
T21185 13281-13289 NN denotes Bleeding
T21183 13290-13294 NN denotes time
T21186 13295-13296 -LRB- denotes (
T21187 13296-13303 NNS denotes seconds
T21188 13303-13304 -RRB- denotes )
T21189 13305-13308 CC denotes and
T21190 13309-13314 NN denotes Panel
T21192 13315-13316 NN denotes C
T21193 13316-13318 , denotes ,
T21191 13318-13319 NN denotes D
T21195 13319-13321 : denotes :
T21196 13321-13331 NN denotes Rebleeding
T21194 13332-13336 NN denotes time
T21197 13337-13338 -LRB- denotes (
T21198 13338-13345 NNS denotes seconds
T21199 13345-13346 -RRB- denotes )
T21200 13346-13347 . denotes .
T21201 13347-13574 sentence denotes To determine statistical differences, values from B6 and A/J and from WT and Plg-/- littermates were compared with a t-test, and values from B6, PAI-1-/- and Lepob were compared by a one-way ANOVA and a Newman-Keuls post-test.
T21202 13348-13350 TO denotes To
T21203 13351-13360 VB denotes determine
T21205 13361-13372 JJ denotes statistical
T21206 13373-13384 NNS denotes differences
T21207 13384-13386 , denotes ,
T21208 13386-13392 NNS denotes values
T21209 13393-13397 IN denotes from
T21210 13398-13400 NN denotes B6
T21211 13401-13404 CC denotes and
T21212 13405-13406 NN denotes A
T21214 13406-13407 HYPH denotes /
T21213 13407-13408 NN denotes J
T21215 13409-13412 CC denotes and
T21216 13413-13417 IN denotes from
T21217 13418-13420 NN denotes WT
T21218 13421-13424 CC denotes and
T21219 13425-13428 NN denotes Plg
T21220 13428-13429 SYM denotes -
T21221 13429-13430 HYPH denotes /
T21222 13430-13431 SYM denotes -
T21223 13432-13443 NNS denotes littermates
T21224 13444-13448 VBD denotes were
T21204 13449-13457 VBN denotes compared
T21225 13458-13462 IN denotes with
T21226 13463-13464 DT denotes a
T21228 13465-13466 NN denotes t
T21229 13466-13467 HYPH denotes -
T21227 13467-13471 NN denotes test
T21230 13471-13473 , denotes ,
T21231 13473-13476 CC denotes and
T21232 13477-13483 NNS denotes values
T21234 13484-13488 IN denotes from
T21235 13489-13491 NN denotes B6
T21236 13491-13493 , denotes ,
T21237 13493-13496 NN denotes PAI
T21238 13496-13497 HYPH denotes -
T21239 13497-13498 CD denotes 1
T21240 13498-13499 SYM denotes -
T21241 13499-13500 HYPH denotes /
T21242 13500-13501 SYM denotes -
T21243 13502-13505 CC denotes and
T21244 13506-13511 NN denotes Lepob
T21245 13512-13516 VBD denotes were
T21233 13517-13525 VBN denotes compared
T21246 13526-13528 IN denotes by
T21247 13529-13530 DT denotes a
T21249 13531-13534 CD denotes one
T21251 13534-13535 HYPH denotes -
T21250 13535-13538 NN denotes way
T21248 13539-13544 NN denotes ANOVA
T21252 13545-13548 CC denotes and
T21253 13549-13550 DT denotes a
T21255 13551-13557 NNP denotes Newman
T21257 13557-13558 HYPH denotes -
T21256 13558-13563 NNP denotes Keuls
T21254 13564-13573 NN denotes post-test
T21258 13573-13574 . denotes .
T21259 13574-13677 sentence denotes Symbols indicate a significant difference (*P < 0.05, **P < 0.01, ***P < 0.001) between B6 or WT mice.
T21260 13575-13582 NNS denotes Symbols
T21261 13583-13591 VBP denotes indicate
T21262 13592-13593 DT denotes a
T21264 13594-13605 JJ denotes significant
T21263 13606-13616 NN denotes difference
T21265 13617-13618 -LRB- denotes (
T21267 13618-13619 SYM denotes *
T21268 13619-13620 NN denotes P
T21270 13621-13622 SYM denotes <
T21269 13623-13627 CD denotes 0.05
T21271 13627-13629 , denotes ,
T21272 13629-13631 SYM denotes **
T21273 13631-13632 NN denotes P
T21275 13633-13634 SYM denotes <
T21274 13635-13639 CD denotes 0.01
T21276 13639-13641 , denotes ,
T21277 13641-13644 SYM denotes ***
T21278 13644-13645 NN denotes P
T21279 13646-13647 SYM denotes <
T21266 13648-13653 CD denotes 0.001
T21280 13653-13654 -RRB- denotes )
T21281 13655-13662 IN denotes between
T21282 13663-13665 NN denotes B6
T21284 13666-13668 CC denotes or
T21285 13669-13671 NN denotes WT
T21283 13672-13676 NNS denotes mice
T21286 13676-13677 . denotes .
T21287 13677-13731 sentence denotes Values are the mean ± SEM of 10–34 mice per genotype.
T21288 13678-13684 NNS denotes Values
T21289 13685-13688 VBP denotes are
T21290 13689-13692 DT denotes the
T21292 13693-13697 NN denotes mean
T21293 13698-13699 SYM denotes ±
T21291 13700-13703 NN denotes SEM
T21294 13704-13706 IN denotes of
T21295 13707-13709 CD denotes 10
T21297 13709-13710 SYM denotes –
T21296 13710-13712 CD denotes 34
T21298 13713-13717 NNS denotes mice
T21299 13718-13721 IN denotes per
T21300 13722-13730 NN denotes genotype
T21301 13730-13731 . denotes .
T9675 13732-13742 NN denotes Rebleeding
T9676 13743-13747 NN denotes time
T9678 13747-13749 , denotes ,
T9679 13749-13751 DT denotes an
T9680 13752-13761 NN denotes indicator
T9681 13762-13764 IN denotes of
T9682 13765-13773 NN denotes thrombus
T9683 13774-13783 NN denotes stability
T9684 13783-13785 , denotes ,
T9685 13785-13788 VBD denotes was
T9677 13789-13797 VBN denotes measured
T9686 13798-13800 IN denotes as
T9687 13801-13804 DT denotes the
T9688 13805-13809 NN denotes time
T9689 13810-13817 IN denotes between
T9690 13818-13821 DT denotes the
T9691 13822-13831 NN denotes cessation
T9692 13832-13834 IN denotes of
T9693 13835-13843 NN denotes bleeding
T9694 13844-13847 CC denotes and
T9695 13848-13851 DT denotes the
T9696 13852-13857 NN denotes start
T9697 13858-13860 IN denotes of
T9698 13861-13864 DT denotes the
T9700 13865-13871 JJ denotes second
T9699 13872-13880 NN denotes bleeding
T9701 13881-13882 -LRB- denotes (
T9703 13882-13888 NN denotes Figure
T9702 13889-13891 NN denotes 2B
T9704 13891-13892 -RRB- denotes )
T9705 13892-13893 . denotes .
T9706 13893-13988 sentence denotes Rebleeding times were significantly higher in A/J (2.6-fold, P < 0.001) mice than the B6 mice.
T9707 13894-13904 NN denotes Rebleeding
T9708 13905-13910 NNS denotes times
T9709 13911-13915 VBD denotes were
T9710 13916-13929 RB denotes significantly
T9711 13930-13936 JJR denotes higher
T9712 13937-13939 IN denotes in
T9713 13940-13941 NN denotes A
T9715 13941-13942 HYPH denotes /
T9714 13942-13943 NN denotes J
T9717 13944-13945 -LRB- denotes (
T9718 13945-13953 RB denotes 2.6-fold
T9719 13953-13955 , denotes ,
T9720 13955-13956 NN denotes P
T9722 13957-13958 SYM denotes <
T9721 13959-13964 CD denotes 0.001
T9723 13964-13965 -RRB- denotes )
T9716 13966-13970 NNS denotes mice
T9724 13971-13975 IN denotes than
T9725 13976-13979 DT denotes the
T9727 13980-13982 NN denotes B6
T9726 13983-13987 NNS denotes mice
T9728 13987-13988 . denotes .
T9729 13988-14082 sentence denotes In contrast, the rebleeding time was nearly 8.5-fold less in the Lepob mice than the B6 mice.
T9730 13989-13991 IN denotes In
T9732 13992-14000 NN denotes contrast
T9733 14000-14002 , denotes ,
T9734 14002-14005 DT denotes the
T9736 14006-14016 NN denotes rebleeding
T9735 14017-14021 NN denotes time
T9731 14022-14025 VBD denotes was
T9737 14026-14032 RB denotes nearly
T9738 14033-14041 RB denotes 8.5-fold
T9739 14042-14046 JJR denotes less
T9740 14047-14049 IN denotes in
T9741 14050-14053 DT denotes the
T9743 14054-14059 NN denotes Lepob
T9742 14060-14064 NNS denotes mice
T9744 14065-14069 IN denotes than
T9745 14070-14073 DT denotes the
T9747 14074-14076 NN denotes B6
T9746 14077-14081 NNS denotes mice
T9748 14081-14082 . denotes .
T9749 14082-14221 sentence denotes To determine how alterations in the fibrinolytic system may affect rebleeding time, Plg-/- and PAI-1-/- mice were also tested (Figure 2B).
T9750 14083-14085 TO denotes To
T9751 14086-14095 VB denotes determine
T9753 14096-14099 WRB denotes how
T9755 14100-14111 NNS denotes alterations
T9756 14112-14114 IN denotes in
T9757 14115-14118 DT denotes the
T9759 14119-14131 JJ denotes fibrinolytic
T9758 14132-14138 NN denotes system
T9760 14139-14142 MD denotes may
T9754 14143-14149 VB denotes affect
T9761 14150-14160 NN denotes rebleeding
T9762 14161-14165 NN denotes time
T9763 14165-14167 , denotes ,
T9764 14167-14170 NN denotes Plg
T9766 14170-14171 SYM denotes -
T9767 14171-14172 HYPH denotes /
T9768 14172-14173 SYM denotes -
T9769 14174-14177 CC denotes and
T9770 14178-14181 NN denotes PAI
T9771 14181-14182 HYPH denotes -
T9772 14182-14183 CD denotes 1
T9773 14183-14184 SYM denotes -
T9774 14184-14185 HYPH denotes /
T9775 14185-14186 SYM denotes -
T9765 14187-14191 NNS denotes mice
T9776 14192-14196 VBD denotes were
T9777 14197-14201 RB denotes also
T9752 14202-14208 VBN denotes tested
T9778 14209-14210 -LRB- denotes (
T9780 14210-14216 NN denotes Figure
T9779 14217-14219 NN denotes 2B
T9781 14219-14220 -RRB- denotes )
T9782 14220-14221 . denotes .
T9783 14221-14419 sentence denotes Rebleeding time was not different in Plg-/- mice compared to WT littermates, but PAI-1-/- mice had a significantly (P < 0.05) reduced rebleeding time, which was 1.8-fold lower than for the B6 mice.
T9784 14222-14232 VBG denotes Rebleeding
T9785 14233-14237 NN denotes time
T9786 14238-14241 VBD denotes was
T9787 14242-14245 RB denotes not
T9788 14246-14255 JJ denotes different
T9789 14256-14258 IN denotes in
T9790 14259-14262 NN denotes Plg
T9792 14262-14263 SYM denotes -
T9793 14263-14264 HYPH denotes /
T9794 14264-14265 SYM denotes -
T9791 14266-14270 NNS denotes mice
T9795 14271-14279 VBN denotes compared
T9796 14280-14282 IN denotes to
T9797 14283-14285 NN denotes WT
T9798 14286-14297 NNS denotes littermates
T9799 14297-14299 , denotes ,
T9800 14299-14302 CC denotes but
T9801 14303-14306 NN denotes PAI
T9803 14306-14307 HYPH denotes -
T9804 14307-14308 CD denotes 1
T9805 14308-14309 SYM denotes -
T9806 14309-14310 HYPH denotes /
T9807 14310-14311 SYM denotes -
T9802 14312-14316 NNS denotes mice
T9808 14317-14320 VBD denotes had
T9809 14321-14322 DT denotes a
T9811 14323-14336 RB denotes significantly
T9813 14337-14338 -LRB- denotes (
T9815 14338-14339 NN denotes P
T9816 14340-14341 SYM denotes <
T9814 14342-14346 CD denotes 0.05
T9817 14346-14347 -RRB- denotes )
T9812 14348-14355 VBN denotes reduced
T9818 14356-14366 NN denotes rebleeding
T9810 14367-14371 NN denotes time
T9819 14371-14373 , denotes ,
T9820 14373-14378 WDT denotes which
T9821 14379-14382 VBD denotes was
T9822 14383-14391 RB denotes 1.8-fold
T9823 14392-14397 JJR denotes lower
T9824 14398-14402 IN denotes than
T9825 14403-14406 IN denotes for
T9826 14407-14410 DT denotes the
T9828 14411-14413 NN denotes B6
T9827 14414-14418 NNS denotes mice
T9829 14418-14419 . denotes .
T9830 14419-14556 sentence denotes Although a Plg deficiency did not result in a prolonged rebleeding time as anticipated, a PAI-1 deficiency resulted in a shortened time.
T9831 14420-14428 IN denotes Although
T9833 14429-14430 DT denotes a
T9835 14431-14434 NN denotes Plg
T9834 14435-14445 NN denotes deficiency
T9836 14446-14449 VBD denotes did
T9837 14450-14453 RB denotes not
T9832 14454-14460 VB denotes result
T9839 14461-14463 IN denotes in
T9840 14464-14465 DT denotes a
T9842 14466-14475 JJ denotes prolonged
T9843 14476-14486 NN denotes rebleeding
T9841 14487-14491 NN denotes time
T9844 14492-14494 IN denotes as
T9845 14495-14506 VBN denotes anticipated
T9846 14506-14508 , denotes ,
T9847 14508-14509 DT denotes a
T9849 14510-14513 NN denotes PAI
T9850 14513-14514 HYPH denotes -
T9851 14514-14515 CD denotes 1
T9848 14516-14526 NN denotes deficiency
T9838 14527-14535 VBD denotes resulted
T9852 14536-14538 IN denotes in
T9853 14539-14540 DT denotes a
T9855 14541-14550 VBN denotes shortened
T9854 14551-14555 NN denotes time
T9856 14555-14556 . denotes .
T9857 14556-14668 sentence denotes The markedly increased rebleeding time in the A/J may suggest differences in the regulation of the Plg network.
T9858 14557-14560 DT denotes The
T9860 14561-14569 RB denotes markedly
T9861 14570-14579 VBN denotes increased
T9862 14580-14590 NN denotes rebleeding
T9859 14591-14595 NN denotes time
T9864 14596-14598 IN denotes in
T9865 14599-14602 DT denotes the
T9867 14603-14604 NN denotes A
T9868 14604-14605 HYPH denotes /
T9866 14605-14606 NN denotes J
T9869 14607-14610 MD denotes may
T9863 14611-14618 VB denotes suggest
T9870 14619-14630 NNS denotes differences
T9871 14631-14633 IN denotes in
T9872 14634-14637 DT denotes the
T9873 14638-14648 NN denotes regulation
T9874 14649-14651 IN denotes of
T9875 14652-14655 DT denotes the
T9877 14656-14659 NN denotes Plg
T9876 14660-14667 NN denotes network
T9878 14667-14668 . denotes .
T10215 14670-14672 DT denotes No
T10216 14673-14683 NN denotes difference
T10217 14684-14686 IN denotes in
T10218 14687-14692 NN denotes blood
T10219 14693-14704 NN denotes coagulation
T10220 14705-14712 IN denotes between
T10221 14713-14715 NN denotes B6
T10223 14716-14719 CC denotes and
T10224 14720-14721 NN denotes A
T10226 14721-14722 HYPH denotes /
T10225 14722-14723 NN denotes J
T10222 14724-14728 NNS denotes mice
T10227 14728-14923 sentence denotes To determine if differences in coagulation were contributing factors to the bleeding and rebleeding results, prothrombin time (PT) and activated partial thromboplastin time (aPTT) were measured.
T10228 14729-14731 TO denotes To
T10229 14732-14741 VB denotes determine
T10231 14742-14744 IN denotes if
T10233 14745-14756 NNS denotes differences
T10234 14757-14759 IN denotes in
T10235 14760-14771 NN denotes coagulation
T10232 14772-14776 VBD denotes were
T10236 14777-14789 VBG denotes contributing
T10237 14790-14797 NNS denotes factors
T10238 14798-14800 IN denotes to
T10239 14801-14804 DT denotes the
T10241 14805-14813 NN denotes bleeding
T10242 14814-14817 CC denotes and
T10243 14818-14828 NN denotes rebleeding
T10240 14829-14836 NNS denotes results
T10244 14836-14838 , denotes ,
T10245 14838-14849 NN denotes prothrombin
T10246 14850-14854 NN denotes time
T10247 14855-14856 -LRB- denotes (
T10248 14856-14858 NN denotes PT
T10249 14858-14859 -RRB- denotes )
T10250 14860-14863 CC denotes and
T10251 14864-14873 VBN denotes activated
T10253 14874-14881 JJ denotes partial
T10254 14882-14896 NN denotes thromboplastin
T10252 14897-14901 NN denotes time
T10255 14902-14903 -LRB- denotes (
T10256 14903-14907 NN denotes aPTT
T10257 14907-14908 -RRB- denotes )
T10258 14909-14913 VBD denotes were
T10230 14914-14922 VBN denotes measured
T10259 14922-14923 . denotes .
T10260 14923-15123 sentence denotes PT is a measurement of the extrinsic coagulation pathway (activation of Factor VII by tissue factor) while aPTT is a measurement of the intrinsic pathway (activation of Factors XII, XI, IX and VIII).
T10261 14924-14926 NN denotes PT
T10262 14927-14929 VBZ denotes is
T10263 14930-14931 DT denotes a
T10264 14932-14943 NN denotes measurement
T10265 14944-14946 IN denotes of
T10266 14947-14950 DT denotes the
T10268 14951-14960 JJ denotes extrinsic
T10269 14961-14972 NN denotes coagulation
T10267 14973-14980 NN denotes pathway
T10270 14981-14982 -LRB- denotes (
T10271 14982-14992 NN denotes activation
T10272 14993-14995 IN denotes of
T10273 14996-15002 NN denotes Factor
T10274 15003-15006 CD denotes VII
T10275 15007-15009 IN denotes by
T10276 15010-15016 NN denotes tissue
T10277 15017-15023 NN denotes factor
T10278 15023-15024 -RRB- denotes )
T10279 15025-15030 IN denotes while
T10281 15031-15035 NN denotes aPTT
T10280 15036-15038 VBZ denotes is
T10282 15039-15040 DT denotes a
T10283 15041-15052 NN denotes measurement
T10284 15053-15055 IN denotes of
T10285 15056-15059 DT denotes the
T10287 15060-15069 JJ denotes intrinsic
T10286 15070-15077 NN denotes pathway
T10288 15078-15079 -LRB- denotes (
T10289 15079-15089 NN denotes activation
T10290 15090-15092 IN denotes of
T10291 15093-15100 NNS denotes Factors
T10292 15101-15104 CD denotes XII
T10293 15104-15106 , denotes ,
T10294 15106-15108 CD denotes XI
T10295 15108-15110 , denotes ,
T10296 15110-15112 CD denotes IX
T10297 15113-15116 CC denotes and
T10298 15117-15121 CD denotes VIII
T10299 15121-15122 -RRB- denotes )
T10300 15122-15123 . denotes .
T10301 15123-15265 sentence denotes The products of both pathways activate Factor X, which initiates the common pathway leading to thrombin generation and fibrin clot formation.
T10302 15124-15127 DT denotes The
T10303 15128-15136 NNS denotes products
T10305 15137-15139 IN denotes of
T10306 15140-15144 DT denotes both
T10307 15145-15153 NNS denotes pathways
T10304 15154-15162 VBP denotes activate
T10308 15163-15169 NN denotes Factor
T10309 15170-15171 CD denotes X
T10310 15171-15173 , denotes ,
T10311 15173-15178 WDT denotes which
T10312 15179-15188 VBZ denotes initiates
T10313 15189-15192 DT denotes the
T10315 15193-15199 JJ denotes common
T10314 15200-15207 NN denotes pathway
T10316 15208-15215 VBG denotes leading
T10317 15216-15218 IN denotes to
T10318 15219-15227 NN denotes thrombin
T10319 15228-15238 NN denotes generation
T10320 15239-15242 CC denotes and
T10321 15243-15249 NN denotes fibrin
T10322 15250-15254 NN denotes clot
T10323 15255-15264 NN denotes formation
T10324 15264-15265 . denotes .
T10325 15265-15385 sentence denotes PT and aPTT were measured in the B6 and A/J mice and values were not different between the two mouse strains (Table 2).
T10326 15266-15268 NN denotes PT
T10328 15269-15272 CC denotes and
T10329 15273-15277 NN denotes aPTT
T10330 15278-15282 VBD denotes were
T10327 15283-15291 VBN denotes measured
T10331 15292-15294 IN denotes in
T10332 15295-15298 DT denotes the
T10334 15299-15301 NN denotes B6
T10335 15302-15305 CC denotes and
T10336 15306-15307 NN denotes A
T10338 15307-15308 HYPH denotes /
T10337 15308-15309 NN denotes J
T10333 15310-15314 NNS denotes mice
T10339 15315-15318 CC denotes and
T10340 15319-15325 NNS denotes values
T10341 15326-15330 VBD denotes were
T10342 15331-15334 RB denotes not
T10343 15335-15344 JJ denotes different
T10344 15345-15352 IN denotes between
T10345 15353-15356 DT denotes the
T10347 15357-15360 CD denotes two
T10348 15361-15366 NN denotes mouse
T10346 15367-15374 NNS denotes strains
T10349 15375-15376 -LRB- denotes (
T10350 15376-15381 NN denotes Table
T10351 15382-15383 CD denotes 2
T10352 15383-15384 -RRB- denotes )
T10353 15384-15385 . denotes .
T10354 15385-15480 sentence denotes These results suggest that the coagulation pathway is not different in the two inbred strains.
T10355 15386-15391 DT denotes These
T10356 15392-15399 NNS denotes results
T10357 15400-15407 VBP denotes suggest
T10358 15408-15412 IN denotes that
T10360 15413-15416 DT denotes the
T10362 15417-15428 NN denotes coagulation
T10361 15429-15436 NN denotes pathway
T10359 15437-15439 VBZ denotes is
T10363 15440-15443 RB denotes not
T10364 15444-15453 JJ denotes different
T10365 15454-15456 IN denotes in
T10366 15457-15460 DT denotes the
T10368 15461-15464 CD denotes two
T10369 15465-15471 JJ denotes inbred
T10367 15472-15479 NNS denotes strains
T10370 15479-15480 . denotes .
T23141 15490-15501 NN denotes Coagulation
T23143 15502-15505 CC denotes and
T23144 15506-15517 NN denotes Plasminogen
T23145 15518-15524 NN denotes System
T23142 15525-15535 NNS denotes Parameters
T23146 15536-15538 IN denotes in
T23147 15539-15541 NN denotes B6
T23149 15542-15545 CC denotes and
T23150 15546-15547 NN denotes A
T23152 15547-15548 HYPH denotes /
T23151 15548-15549 NN denotes J
T23153 15550-15556 JJ denotes inbred
T23154 15557-15562 NN denotes mouse
T23148 15563-15570 NNS denotes strains
T10951 15975-15978 NN denotes Plg
T10953 15979-15982 CC denotes and
T10954 15983-15986 NN denotes PAI
T10955 15986-15987 HYPH denotes -
T10956 15987-15988 CD denotes 1
T10952 15989-15995 JJR denotes higher
T10957 15996-15998 IN denotes in
T10958 15999-16000 NN denotes A
T10960 16000-16001 HYPH denotes /
T10959 16001-16002 NN denotes J
T10961 16003-16007 IN denotes than
T10962 16008-16010 NN denotes B6
T10963 16011-16015 NNS denotes mice
T10964 16015-16081 sentence denotes Plg concentration was 34% higher in the A/J mice than in B6 mice.
T10965 16016-16019 NN denotes Plg
T10966 16020-16033 NN denotes concentration
T10967 16034-16037 VBD denotes was
T10968 16038-16040 CD denotes 34
T10969 16040-16041 NN denotes %
T10970 16042-16048 JJR denotes higher
T10971 16049-16051 IN denotes in
T10972 16052-16055 DT denotes the
T10974 16056-16057 NN denotes A
T10976 16057-16058 HYPH denotes /
T10975 16058-16059 NN denotes J
T10973 16060-16064 NNS denotes mice
T10977 16065-16069 IN denotes than
T10978 16070-16072 IN denotes in
T10979 16073-16075 NN denotes B6
T10980 16076-16080 NNS denotes mice
T10981 16080-16081 . denotes .
T10982 16081-16228 sentence denotes In addition, fibrinolytic activity, PAI-1 activity, and α2-anitplasmin were also increased in the A/J mice when compared to the B6 mice (Table 2).
T10983 16082-16084 IN denotes In
T10985 16085-16093 NN denotes addition
T10986 16093-16095 , denotes ,
T10987 16095-16107 JJ denotes fibrinolytic
T10988 16108-16116 NN denotes activity
T10989 16116-16118 , denotes ,
T10990 16118-16121 NN denotes PAI
T10992 16121-16122 HYPH denotes -
T10993 16122-16123 CD denotes 1
T10991 16124-16132 NN denotes activity
T10994 16132-16134 , denotes ,
T10995 16134-16137 CC denotes and
T10996 16138-16140 NN denotes α2
T10998 16140-16141 HYPH denotes -
T10997 16141-16152 NN denotes anitplasmin
T10999 16153-16157 VBD denotes were
T11000 16158-16162 RB denotes also
T10984 16163-16172 VBN denotes increased
T11001 16173-16175 IN denotes in
T11002 16176-16179 DT denotes the
T11004 16180-16181 NN denotes A
T11006 16181-16182 SYM denotes /
T11005 16182-16183 NN denotes J
T11003 16184-16188 NNS denotes mice
T11007 16189-16193 WRB denotes when
T11008 16194-16202 VBN denotes compared
T11009 16203-16205 IN denotes to
T11010 16206-16209 DT denotes the
T11012 16210-16212 NN denotes B6
T11011 16213-16217 NNS denotes mice
T11013 16218-16219 -LRB- denotes (
T11014 16219-16224 NN denotes Table
T11015 16225-16226 CD denotes 2
T11016 16226-16227 -RRB- denotes )
T11017 16227-16228 . denotes .
T11018 16228-16341 sentence denotes The functional consequences of these differences are not clear, since fibrinogen is also higher in the A/J mice.
T11019 16229-16232 DT denotes The
T11021 16233-16243 JJ denotes functional
T11020 16244-16256 NNS denotes consequences
T11023 16257-16259 IN denotes of
T11024 16260-16265 DT denotes these
T11025 16266-16277 NNS denotes differences
T11022 16278-16281 VBP denotes are
T11026 16282-16285 RB denotes not
T11027 16286-16291 JJ denotes clear
T11028 16291-16293 , denotes ,
T11029 16293-16298 IN denotes since
T11031 16299-16309 NN denotes fibrinogen
T11030 16310-16312 VBZ denotes is
T11032 16313-16317 RB denotes also
T11033 16318-16324 JJR denotes higher
T11034 16325-16327 IN denotes in
T11035 16328-16331 DT denotes the
T11037 16332-16333 NN denotes A
T11039 16333-16334 HYPH denotes /
T11038 16334-16335 NN denotes J
T11036 16336-16340 NNS denotes mice
T11040 16340-16341 . denotes .
T11041 16341-16554 sentence denotes To determine whether there were protein structure changes of Plg from the A/J mice, plasma from the B6 and the A/J mice were subjected to electrophoresis under reduced, non-reduced, and non-denaturing conditions.
T11042 16342-16344 TO denotes To
T11043 16345-16354 VB denotes determine
T11045 16355-16362 IN denotes whether
T11047 16363-16368 EX denotes there
T11046 16369-16373 VBD denotes were
T11048 16374-16381 NN denotes protein
T11049 16382-16391 NN denotes structure
T11050 16392-16399 NNS denotes changes
T11051 16400-16402 IN denotes of
T11052 16403-16406 NN denotes Plg
T11053 16407-16411 IN denotes from
T11054 16412-16415 DT denotes the
T11056 16416-16417 NN denotes A
T11058 16417-16418 HYPH denotes /
T11057 16418-16419 NN denotes J
T11055 16420-16424 NNS denotes mice
T11059 16424-16426 , denotes ,
T11060 16426-16432 NN denotes plasma
T11061 16433-16437 IN denotes from
T11062 16438-16441 DT denotes the
T11063 16442-16444 NN denotes B6
T11064 16445-16448 CC denotes and
T11065 16449-16452 DT denotes the
T11067 16453-16454 NN denotes A
T11068 16454-16455 HYPH denotes /
T11066 16455-16456 NN denotes J
T11069 16457-16461 NNS denotes mice
T11070 16462-16466 VBD denotes were
T11044 16467-16476 VBN denotes subjected
T11071 16477-16479 IN denotes to
T11072 16480-16495 NN denotes electrophoresis
T11073 16496-16501 IN denotes under
T11074 16502-16509 VBN denotes reduced
T11076 16509-16511 , denotes ,
T11077 16511-16522 JJ denotes non-reduced
T11078 16522-16524 , denotes ,
T11079 16524-16527 CC denotes and
T11080 16528-16542 VBG denotes non-denaturing
T11075 16543-16553 NNS denotes conditions
T11081 16553-16554 . denotes .
T11082 16554-16657 sentence denotes No difference in migration for immunostained Plg under these conditions was observed (data not shown).
T11083 16555-16557 DT denotes No
T11084 16558-16568 NN denotes difference
T11086 16569-16571 IN denotes in
T11087 16572-16581 NN denotes migration
T11088 16582-16585 IN denotes for
T11089 16586-16599 VBN denotes immunostained
T11090 16600-16603 NN denotes Plg
T11091 16604-16609 IN denotes under
T11092 16610-16615 DT denotes these
T11093 16616-16626 NNS denotes conditions
T11094 16627-16630 VBD denotes was
T11085 16631-16639 VBN denotes observed
T11095 16640-16641 -LRB- denotes (
T11097 16641-16645 NNS denotes data
T11098 16646-16649 RB denotes not
T11096 16650-16655 VBN denotes shown
T11099 16655-16656 -RRB- denotes )
T11100 16656-16657 . denotes .
T11101 16657-16966 sentence denotes The density of the Western blot from SDS-PAGE under reducing conditions of plasma of varying volumes from B6 and A/J mice was compared and the density of the bands was 56% higher in the A/J than the B6 mice (six individual mice were tested on at least two occasions) from the same amount of plasma (Fig. 1B).
T11102 16658-16661 DT denotes The
T11103 16662-16669 NN denotes density
T11105 16670-16672 IN denotes of
T11106 16673-16676 DT denotes the
T11108 16677-16684 NNP denotes Western
T11107 16685-16689 NN denotes blot
T11109 16690-16694 IN denotes from
T11110 16695-16698 NN denotes SDS
T11112 16698-16699 HYPH denotes -
T11111 16699-16703 NN denotes PAGE
T11113 16704-16709 IN denotes under
T11114 16710-16718 NN denotes reducing
T11115 16719-16729 NNS denotes conditions
T11116 16730-16732 IN denotes of
T11117 16733-16739 NN denotes plasma
T11118 16740-16742 IN denotes of
T11119 16743-16750 VBG denotes varying
T11120 16751-16758 NNS denotes volumes
T11121 16759-16763 IN denotes from
T11122 16764-16766 NN denotes B6
T11124 16767-16770 CC denotes and
T11125 16771-16772 NN denotes A
T11127 16772-16773 HYPH denotes /
T11126 16773-16774 NN denotes J
T11123 16775-16779 NNS denotes mice
T11128 16780-16783 VBD denotes was
T11104 16784-16792 VBN denotes compared
T11129 16793-16796 CC denotes and
T11130 16797-16800 DT denotes the
T11131 16801-16808 NN denotes density
T11133 16809-16811 IN denotes of
T11134 16812-16815 DT denotes the
T11135 16816-16821 NNS denotes bands
T11132 16822-16825 VBD denotes was
T11136 16826-16828 CD denotes 56
T11137 16828-16829 NN denotes %
T11138 16830-16836 JJR denotes higher
T11139 16837-16839 IN denotes in
T11140 16840-16843 DT denotes the
T11142 16844-16845 NN denotes A
T11143 16845-16846 HYPH denotes /
T11141 16846-16847 NN denotes J
T11144 16848-16852 IN denotes than
T11145 16853-16856 DT denotes the
T11146 16857-16859 NN denotes B6
T11147 16860-16864 NNS denotes mice
T11148 16865-16866 -LRB- denotes (
T11150 16866-16869 CD denotes six
T11152 16870-16880 JJ denotes individual
T11151 16881-16885 NNS denotes mice
T11153 16886-16890 VBD denotes were
T11149 16891-16897 VBN denotes tested
T11154 16898-16900 IN denotes on
T11155 16901-16903 RB denotes at
T11157 16904-16909 RBS denotes least
T11156 16910-16913 CD denotes two
T11158 16914-16923 NNS denotes occasions
T11159 16923-16924 -RRB- denotes )
T11160 16925-16929 IN denotes from
T11161 16930-16933 DT denotes the
T11163 16934-16938 JJ denotes same
T11162 16939-16945 NN denotes amount
T11164 16946-16948 IN denotes of
T11165 16949-16955 NN denotes plasma
T11166 16956-16957 -LRB- denotes (
T11168 16957-16961 NN denotes Fig.
T11167 16962-16964 NN denotes 1B
T11169 16964-16965 -RRB- denotes )
T11170 16965-16966 . denotes .
T11171 16966-17240 sentence denotes Thus, the concentration of Plg in plasma from the A/J mice was higher than plasma from the B6 mice as determined by two methods and no difference in migration after electrophoresis was observed, suggesting no marked changes in the structure of Plg in the two mouse strains.
T11172 16967-16971 RB denotes Thus
T11174 16971-16973 , denotes ,
T11175 16973-16976 DT denotes the
T11176 16977-16990 NN denotes concentration
T11177 16991-16993 IN denotes of
T11178 16994-16997 NN denotes Plg
T11179 16998-17000 IN denotes in
T11180 17001-17007 NN denotes plasma
T11181 17008-17012 IN denotes from
T11182 17013-17016 DT denotes the
T11184 17017-17018 NN denotes A
T11186 17018-17019 HYPH denotes /
T11185 17019-17020 NN denotes J
T11183 17021-17025 NNS denotes mice
T11173 17026-17029 VBD denotes was
T11187 17030-17036 JJR denotes higher
T11188 17037-17041 IN denotes than
T11189 17042-17048 NN denotes plasma
T11190 17049-17053 IN denotes from
T11191 17054-17057 DT denotes the
T11193 17058-17060 NN denotes B6
T11192 17061-17065 NNS denotes mice
T11194 17066-17068 IN denotes as
T11195 17069-17079 VBN denotes determined
T11196 17080-17082 IN denotes by
T11197 17083-17086 CD denotes two
T11198 17087-17094 NNS denotes methods
T11199 17095-17098 CC denotes and
T11200 17099-17101 DT denotes no
T11201 17102-17112 NN denotes difference
T11203 17113-17115 IN denotes in
T11204 17116-17125 NN denotes migration
T11205 17126-17131 IN denotes after
T11206 17132-17147 NN denotes electrophoresis
T11207 17148-17151 VBD denotes was
T11202 17152-17160 VBN denotes observed
T11208 17160-17162 , denotes ,
T11209 17162-17172 VBG denotes suggesting
T11210 17173-17175 DT denotes no
T11212 17176-17182 JJ denotes marked
T11211 17183-17190 NNS denotes changes
T11213 17191-17193 IN denotes in
T11214 17194-17197 DT denotes the
T11215 17198-17207 NN denotes structure
T11216 17208-17210 IN denotes of
T11217 17211-17214 NN denotes Plg
T11218 17215-17217 IN denotes in
T11219 17218-17221 DT denotes the
T11221 17222-17225 CD denotes two
T11222 17226-17231 NN denotes mouse
T11220 17232-17239 NNS denotes strains
T11223 17239-17240 . denotes .
T11637 17242-17246 NN denotes Tail
T11638 17247-17257 NN denotes morphology
T11639 17258-17260 IN denotes in
T11640 17261-17263 NN denotes B6
T11641 17264-17267 CC denotes and
T11642 17268-17269 NN denotes A
T11644 17269-17270 HYPH denotes /
T11643 17270-17271 NN denotes J
T11645 17271-17400 sentence denotes The tails of the mice were examined for differences that might account for the variations in the bleeding and rebleeding values.
T11646 17272-17275 DT denotes The
T11647 17276-17281 NNS denotes tails
T11649 17282-17284 IN denotes of
T11650 17285-17288 DT denotes the
T11651 17289-17293 NNS denotes mice
T11652 17294-17298 VBD denotes were
T11648 17299-17307 VBN denotes examined
T11653 17308-17311 IN denotes for
T11654 17312-17323 NNS denotes differences
T11655 17324-17328 WDT denotes that
T11657 17329-17334 MD denotes might
T11656 17335-17342 VB denotes account
T11658 17343-17346 IN denotes for
T11659 17347-17350 DT denotes the
T11660 17351-17361 NNS denotes variations
T11661 17362-17364 IN denotes in
T11662 17365-17368 DT denotes the
T11664 17369-17377 NN denotes bleeding
T11665 17378-17381 CC denotes and
T11666 17382-17392 NN denotes rebleeding
T11663 17393-17399 NNS denotes values
T11667 17399-17400 . denotes .
T11668 17400-17555 sentence denotes Sections of the tail from the B6 and A/J mice were stained with Hematoxylin/Eosin or Masson's Trichrome and representative sections are shown in Figure 3.
T11669 17401-17409 NNS denotes Sections
T11671 17410-17412 IN denotes of
T11672 17413-17416 DT denotes the
T11673 17417-17421 NN denotes tail
T11674 17422-17426 IN denotes from
T11675 17427-17430 DT denotes the
T11677 17431-17433 NN denotes B6
T11678 17434-17437 CC denotes and
T11679 17438-17439 NN denotes A
T11681 17439-17440 HYPH denotes /
T11680 17440-17441 NN denotes J
T11676 17442-17446 NNS denotes mice
T11682 17447-17451 VBD denotes were
T11670 17452-17459 VBN denotes stained
T11683 17460-17464 IN denotes with
T11684 17465-17476 NN denotes Hematoxylin
T11686 17476-17477 HYPH denotes /
T11685 17477-17482 NN denotes Eosin
T11687 17483-17485 CC denotes or
T11688 17486-17492 NNP denotes Masson
T11690 17492-17494 POS denotes 's
T11689 17495-17504 NN denotes Trichrome
T11691 17505-17508 CC denotes and
T11692 17509-17523 JJ denotes representative
T11693 17524-17532 NNS denotes sections
T11695 17533-17536 VBP denotes are
T11694 17537-17542 VBN denotes shown
T11696 17543-17545 IN denotes in
T11697 17546-17552 NN denotes Figure
T11698 17553-17554 CD denotes 3
T11699 17554-17555 . denotes .
T11700 17555-17717 sentence denotes No obvious qualitative differences were observed in hair follicles, sebaceous glands, or center bone/cartilage in Hematoxylin/Eosin (Figure 3A) stained sections.
T11701 17556-17558 DT denotes No
T11703 17559-17566 JJ denotes obvious
T11704 17567-17578 JJ denotes qualitative
T11702 17579-17590 NNS denotes differences
T11706 17591-17595 VBD denotes were
T11705 17596-17604 VBN denotes observed
T11707 17605-17607 IN denotes in
T11708 17608-17612 NN denotes hair
T11709 17613-17622 NNS denotes follicles
T11710 17622-17624 , denotes ,
T11711 17624-17633 JJ denotes sebaceous
T11712 17634-17640 NNS denotes glands
T11713 17640-17642 , denotes ,
T11714 17642-17644 CC denotes or
T11715 17645-17651 NN denotes center
T11716 17652-17656 NN denotes bone
T11717 17656-17657 HYPH denotes /
T11718 17657-17666 NN denotes cartilage
T11719 17667-17669 IN denotes in
T11720 17670-17681 NN denotes Hematoxylin
T11722 17681-17682 HYPH denotes /
T11721 17682-17687 NN denotes Eosin
T11724 17688-17689 -LRB- denotes (
T11726 17689-17695 NN denotes Figure
T11725 17696-17698 NN denotes 3A
T11727 17698-17699 -RRB- denotes )
T11723 17700-17707 VBN denotes stained
T11728 17708-17716 NNS denotes sections
T11729 17716-17717 . denotes .
T11730 17717-17888 sentence denotes Sections of the tails were stained with Masson's Trichrome (Figure 3B) that detects collagen, the major platelet adhesive substratum for initiation of thrombus formation.
T11731 17718-17726 NNS denotes Sections
T11733 17727-17729 IN denotes of
T11734 17730-17733 DT denotes the
T11735 17734-17739 NNS denotes tails
T11736 17740-17744 VBD denotes were
T11732 17745-17752 VBN denotes stained
T11737 17753-17757 IN denotes with
T11738 17758-17764 NNP denotes Masson
T11740 17764-17766 POS denotes 's
T11739 17767-17776 NN denotes Trichrome
T11741 17777-17778 -LRB- denotes (
T11743 17778-17784 NN denotes Figure
T11742 17785-17787 NN denotes 3B
T11744 17787-17788 -RRB- denotes )
T11745 17789-17793 WDT denotes that
T11746 17794-17801 VBZ denotes detects
T11747 17802-17810 NN denotes collagen
T11748 17810-17812 , denotes ,
T11749 17812-17815 DT denotes the
T11751 17816-17821 JJ denotes major
T11752 17822-17830 NN denotes platelet
T11753 17831-17839 JJ denotes adhesive
T11750 17840-17850 NN denotes substratum
T11754 17851-17854 IN denotes for
T11755 17855-17865 NN denotes initiation
T11756 17866-17868 IN denotes of
T11757 17869-17877 NN denotes thrombus
T11758 17878-17887 NN denotes formation
T11759 17887-17888 . denotes .
T11760 17888-17986 sentence denotes Collagen content (% tail area) was quantified (Figure 3C) from 3–4 sections from 2–3 areas/mouse.
T11761 17889-17897 NN denotes Collagen
T11762 17898-17905 NN denotes content
T11764 17906-17907 -LRB- denotes (
T11766 17907-17908 NN denotes %
T11767 17909-17913 NN denotes tail
T11765 17914-17918 NN denotes area
T11768 17918-17919 -RRB- denotes )
T11769 17920-17923 VBD denotes was
T11763 17924-17934 VBN denotes quantified
T11770 17935-17936 -LRB- denotes (
T11772 17936-17942 NN denotes Figure
T11771 17943-17945 NN denotes 3C
T11773 17945-17946 -RRB- denotes )
T11774 17947-17951 IN denotes from
T11775 17952-17953 CD denotes 3
T11777 17953-17954 SYM denotes –
T11776 17954-17955 CD denotes 4
T11778 17956-17964 NNS denotes sections
T11779 17965-17969 IN denotes from
T11780 17970-17971 CD denotes 2
T11782 17971-17972 SYM denotes –
T11781 17972-17973 CD denotes 3
T11783 17974-17979 NNS denotes areas
T11784 17979-17980 SYM denotes /
T11785 17980-17985 NN denotes mouse
T11786 17985-17986 . denotes .
T11787 17986-18061 sentence denotes The amount of collagen was greater in the A/J than the B6 mice (P < 0.05).
T11788 17987-17990 DT denotes The
T11789 17991-17997 NN denotes amount
T11791 17998-18000 IN denotes of
T11792 18001-18009 NN denotes collagen
T11790 18010-18013 VBD denotes was
T11793 18014-18021 JJR denotes greater
T11794 18022-18024 IN denotes in
T11795 18025-18028 DT denotes the
T11797 18029-18030 NN denotes A
T11798 18030-18031 HYPH denotes /
T11796 18031-18032 NN denotes J
T11799 18033-18037 IN denotes than
T11800 18038-18041 DT denotes the
T11802 18042-18044 NN denotes B6
T11801 18045-18049 NNS denotes mice
T11803 18050-18051 -LRB- denotes (
T11805 18051-18052 NN denotes P
T11806 18053-18054 SYM denotes <
T11804 18055-18059 CD denotes 0.05
T11807 18059-18060 -RRB- denotes )
T11808 18060-18061 . denotes .
T11809 18061-18175 sentence denotes Collagen in vessels in adipose tissue in the A/J mice is also increased compared to the B6 mice (data not shown).
T11810 18062-18070 NN denotes Collagen
T11812 18071-18073 IN denotes in
T11813 18074-18081 NNS denotes vessels
T11814 18082-18084 IN denotes in
T11815 18085-18092 NN denotes adipose
T11816 18093-18099 NN denotes tissue
T11817 18100-18102 IN denotes in
T11818 18103-18106 DT denotes the
T11820 18107-18108 NN denotes A
T11822 18108-18109 HYPH denotes /
T11821 18109-18110 NN denotes J
T11819 18111-18115 NNS denotes mice
T11823 18116-18118 VBZ denotes is
T11824 18119-18123 RB denotes also
T11811 18124-18133 VBN denotes increased
T11825 18134-18142 VBN denotes compared
T11826 18143-18145 IN denotes to
T11827 18146-18149 DT denotes the
T11829 18150-18152 NN denotes B6
T11828 18153-18157 NNS denotes mice
T11830 18158-18159 -LRB- denotes (
T11832 18159-18163 NNS denotes data
T11833 18164-18167 RB denotes not
T11831 18168-18173 VBN denotes shown
T11834 18173-18174 -RRB- denotes )
T11835 18174-18175 . denotes .
T21612 18186-18190 NN denotes Tail
T21613 18191-18201 NN denotes morphology
T21614 18202-18205 CC denotes and
T21615 18206-18214 NN denotes collagen
T21616 18214-18215 . denotes .
T21617 18215-18321 sentence denotes Tails were excised, embedded in OCT, sectioned, and stained with Hematoxylin/Eosin or Masson's Trichrome.
T21618 18216-18221 NNS denotes Tails
T21620 18222-18226 VBD denotes were
T21619 18227-18234 VBN denotes excised
T21621 18234-18236 , denotes ,
T21622 18236-18244 VBN denotes embedded
T21623 18245-18247 IN denotes in
T21624 18248-18251 NN denotes OCT
T21625 18251-18253 , denotes ,
T21626 18253-18262 VBN denotes sectioned
T21627 18262-18264 , denotes ,
T21628 18264-18267 CC denotes and
T21629 18268-18275 VBD denotes stained
T21630 18276-18280 IN denotes with
T21631 18281-18292 NN denotes Hematoxylin
T21633 18292-18293 HYPH denotes /
T21632 18293-18298 NN denotes Eosin
T21634 18299-18301 CC denotes or
T21635 18302-18308 NNP denotes Masson
T21637 18308-18310 POS denotes 's
T21636 18311-18320 NN denotes Trichrome
T21638 18320-18321 . denotes .
T21639 18321-18411 sentence denotes Panel A: Representative sections stained with hematoxylin and eosin from B6 and A/J mice.
T21640 18322-18327 NN denotes Panel
T21641 18328-18329 NN denotes A
T21642 18329-18331 : denotes :
T21643 18331-18345 JJ denotes Representative
T21644 18346-18354 NNS denotes sections
T21645 18355-18362 VBN denotes stained
T21646 18363-18367 IN denotes with
T21647 18368-18379 NN denotes hematoxylin
T21648 18380-18383 CC denotes and
T21649 18384-18389 NN denotes eosin
T21650 18390-18394 IN denotes from
T21651 18395-18397 NN denotes B6
T21653 18398-18401 CC denotes and
T21654 18402-18403 NN denotes A
T21656 18403-18404 HYPH denotes /
T21655 18404-18405 NN denotes J
T21652 18406-18410 NNS denotes mice
T21657 18410-18411 . denotes .
T21658 18411-18498 sentence denotes Panel B: Representative sections stained with Masson's Trichrome from B6 and A/J mice.
T21659 18412-18417 NN denotes Panel
T21660 18418-18419 NN denotes B
T21661 18419-18421 : denotes :
T21662 18421-18435 JJ denotes Representative
T21663 18436-18444 NNS denotes sections
T21664 18445-18452 VBN denotes stained
T21665 18453-18457 IN denotes with
T21666 18458-18464 NNP denotes Masson
T21668 18464-18466 POS denotes 's
T21667 18467-18476 NN denotes Trichrome
T21669 18477-18481 IN denotes from
T21670 18482-18484 NN denotes B6
T21672 18485-18488 CC denotes and
T21673 18489-18490 NN denotes A
T21675 18490-18491 HYPH denotes /
T21674 18491-18492 NN denotes J
T21671 18493-18497 NNS denotes mice
T21676 18497-18498 . denotes .
T21677 18498-18538 sentence denotes The blue color identifies the collagen.
T21678 18499-18502 DT denotes The
T21680 18503-18507 JJ denotes blue
T21679 18508-18513 NN denotes color
T21681 18514-18524 VBZ denotes identifies
T21682 18525-18528 DT denotes the
T21683 18529-18537 NN denotes collagen
T21684 18537-18538 . denotes .
T21685 18538-18743 sentence denotes Panel C: The percentage of the collagen area (excluding center bone/cartilage) of the total tail area of each section was determined in 3–4 sections at 2–3 sites for each tail and averaged for each mouse.
T21686 18539-18544 NN denotes Panel
T21687 18545-18546 NN denotes C
T21689 18546-18548 : denotes :
T21690 18548-18551 DT denotes The
T21691 18552-18562 NN denotes percentage
T21692 18563-18565 IN denotes of
T21693 18566-18569 DT denotes the
T21695 18570-18578 NN denotes collagen
T21694 18579-18583 NN denotes area
T21696 18584-18585 -LRB- denotes (
T21697 18585-18594 VBG denotes excluding
T21698 18595-18601 NN denotes center
T21699 18602-18606 NN denotes bone
T21700 18606-18607 HYPH denotes /
T21701 18607-18616 NN denotes cartilage
T21702 18616-18617 -RRB- denotes )
T21703 18618-18620 IN denotes of
T21704 18621-18624 DT denotes the
T21706 18625-18630 JJ denotes total
T21707 18631-18635 NN denotes tail
T21705 18636-18640 NN denotes area
T21708 18641-18643 IN denotes of
T21709 18644-18648 DT denotes each
T21710 18649-18656 NN denotes section
T21711 18657-18660 VBD denotes was
T21688 18661-18671 VBN denotes determined
T21712 18672-18674 IN denotes in
T21713 18675-18676 CD denotes 3
T21715 18676-18677 SYM denotes –
T21714 18677-18678 CD denotes 4
T21716 18679-18687 NNS denotes sections
T21717 18688-18690 IN denotes at
T21718 18691-18692 CD denotes 2
T21720 18692-18693 SYM denotes –
T21719 18693-18694 CD denotes 3
T21721 18695-18700 NNS denotes sites
T21722 18701-18704 IN denotes for
T21723 18705-18709 DT denotes each
T21724 18710-18714 NN denotes tail
T21725 18715-18718 CC denotes and
T21726 18719-18727 VBD denotes averaged
T21727 18728-18731 IN denotes for
T21728 18732-18736 DT denotes each
T21729 18737-18742 NN denotes mouse
T21730 18742-18743 . denotes .
T21731 18743-18795 sentence denotes Values are the mean ± SEM of 4–8 mice per genotype.
T21732 18744-18750 NNS denotes Values
T21733 18751-18754 VBP denotes are
T21734 18755-18758 DT denotes the
T21736 18759-18763 NN denotes mean
T21737 18764-18765 SYM denotes ±
T21735 18766-18769 NN denotes SEM
T21738 18770-18772 IN denotes of
T21739 18773-18774 CD denotes 4
T21741 18774-18775 SYM denotes –
T21740 18775-18776 CD denotes 8
T21742 18777-18781 NNS denotes mice
T21743 18782-18785 IN denotes per
T21744 18786-18794 NN denotes genotype
T21745 18794-18795 . denotes .
T21746 18795-18887 sentence denotes Symbol indicates a significant difference (*P < 0.05) between B6 mice determined by t-test.
T21747 18796-18802 NN denotes Symbol
T21748 18803-18812 VBZ denotes indicates
T21749 18813-18814 DT denotes a
T21751 18815-18826 JJ denotes significant
T21750 18827-18837 NN denotes difference
T21752 18838-18839 -LRB- denotes (
T21754 18839-18840 SYM denotes *
T21755 18840-18841 NN denotes P
T21756 18842-18843 SYM denotes <
T21753 18844-18848 CD denotes 0.05
T21757 18848-18849 -RRB- denotes )
T21758 18850-18857 IN denotes between
T21759 18858-18860 NN denotes B6
T21760 18861-18865 NNS denotes mice
T21761 18866-18876 VBN denotes determined
T21762 18877-18879 IN denotes by
T21763 18880-18881 NN denotes t
T21765 18881-18882 HYPH denotes -
T21764 18882-18886 NN denotes test
T21766 18886-18887 . denotes .
T12715 18889-18893 NN denotes Tail
T12716 18894-18902 NN denotes bleeding
T12717 18903-18908 NN denotes assay
T12718 18909-18919 VBZ denotes identifies
T12719 18920-18925 CD denotes three
T12720 18926-18937 NNS denotes chromosomes
T12721 18938-18942 IN denotes with
T12722 18943-18946 NN denotes QTL
T12723 18947-18950 IN denotes for
T12724 18951-18961 NN denotes rebleeding
T12725 18962-18964 IN denotes in
T12726 18965-18968 NN denotes CSS
T12727 18968-19085 sentence denotes Using the tail bleeding/rebleeding assay as a surrogate marker for hemostasis and thrombosis, the CSS were screened.
T12728 18969-18974 VBG denotes Using
T12730 18975-18978 DT denotes the
T12732 18979-18983 NN denotes tail
T12734 18984-18992 NN denotes bleeding
T12735 18992-18993 HYPH denotes /
T12733 18993-19003 NN denotes rebleeding
T12731 19004-19009 NN denotes assay
T12736 19010-19012 IN denotes as
T12737 19013-19014 DT denotes a
T12739 19015-19024 JJ denotes surrogate
T12738 19025-19031 NN denotes marker
T12740 19032-19035 IN denotes for
T12741 19036-19046 NN denotes hemostasis
T12742 19047-19050 CC denotes and
T12743 19051-19061 NN denotes thrombosis
T12744 19061-19063 , denotes ,
T12745 19063-19066 DT denotes the
T12746 19067-19070 NN denotes CSS
T12747 19071-19075 VBD denotes were
T12729 19076-19084 VBN denotes screened
T12748 19084-19085 . denotes .
T12749 19085-19324 sentence denotes The bleeding times (Figure 4A) for the B6 and the A/J mice were not different, but 6six of the strains, B6-Chr5, 6, 8, 14, 15, and YA/J, had lower (P < 0.002) bleeding times (49–79 seconds) compared to the value for the B6 mice (121 sec).
T12750 19086-19089 DT denotes The
T12752 19090-19098 NN denotes bleeding
T12751 19099-19104 NNS denotes times
T12754 19105-19106 -LRB- denotes (
T12756 19106-19112 NN denotes Figure
T12755 19113-19115 NN denotes 4A
T12757 19115-19116 -RRB- denotes )
T12758 19117-19120 IN denotes for
T12759 19121-19124 DT denotes the
T12760 19125-19127 NN denotes B6
T12761 19128-19131 CC denotes and
T12762 19132-19135 DT denotes the
T12764 19136-19137 NN denotes A
T12765 19137-19138 HYPH denotes /
T12763 19138-19139 NN denotes J
T12766 19140-19144 NNS denotes mice
T12753 19145-19149 VBD denotes were
T12767 19150-19153 RB denotes not
T12768 19154-19163 JJ denotes different
T12769 19163-19165 , denotes ,
T12770 19165-19168 CC denotes but
T12771 19169-19173 NN denotes 6six
T12773 19174-19176 IN denotes of
T12774 19177-19180 DT denotes the
T12775 19181-19188 NNS denotes strains
T12776 19188-19190 , denotes ,
T12777 19190-19192 NN denotes B6
T12779 19192-19193 HYPH denotes -
T12778 19193-19197 NN denotes Chr5
T12780 19197-19199 , denotes ,
T12781 19199-19200 CD denotes 6
T12782 19200-19202 , denotes ,
T12783 19202-19203 CD denotes 8
T12784 19203-19205 , denotes ,
T12785 19205-19207 CD denotes 14
T12786 19207-19209 , denotes ,
T12787 19209-19211 CD denotes 15
T12788 19211-19213 , denotes ,
T12789 19213-19216 CC denotes and
T12790 19217-19219 NN denotes YA
T12792 19219-19220 HYPH denotes /
T12791 19220-19221 NN denotes J
T12793 19221-19223 , denotes ,
T12772 19223-19226 VBD denotes had
T12794 19227-19232 JJR denotes lower
T12796 19233-19234 -LRB- denotes (
T12798 19234-19235 NN denotes P
T12799 19236-19237 SYM denotes <
T12797 19238-19243 CD denotes 0.002
T12800 19243-19244 -RRB- denotes )
T12801 19245-19253 NN denotes bleeding
T12795 19254-19259 NNS denotes times
T12802 19260-19261 -LRB- denotes (
T12803 19261-19263 CD denotes 49
T12805 19263-19264 SYM denotes –
T12804 19264-19266 CD denotes 79
T12806 19267-19274 NNS denotes seconds
T12807 19274-19275 -RRB- denotes )
T12808 19276-19284 VBN denotes compared
T12809 19285-19287 IN denotes to
T12810 19288-19291 DT denotes the
T12811 19292-19297 NN denotes value
T12812 19298-19301 IN denotes for
T12813 19302-19305 DT denotes the
T12815 19306-19308 NN denotes B6
T12814 19309-19313 NNS denotes mice
T12816 19314-19315 -LRB- denotes (
T12817 19315-19318 CD denotes 121
T12818 19319-19322 NN denotes sec
T12819 19322-19323 -RRB- denotes )
T12820 19323-19324 . denotes .
T12821 19324-19698 sentence denotes The rebleeding time (Figure 4B), determined as the time between bleeding cessation and initiation of the second bleeding, was markedly increased in the A/J mice compared to the B6 mice and two strains, B6-Chr11A/J (CSS-11) and B6-Chr17A/J (CSS-17), had significantly (P < 0.002) longer rebleeding times compared to the B6 mice that were similar to values from the A/J mice.
T12822 19325-19328 DT denotes The
T12824 19329-19339 NN denotes rebleeding
T12823 19340-19344 NN denotes time
T12826 19345-19346 -LRB- denotes (
T12828 19346-19352 NN denotes Figure
T12827 19353-19355 NN denotes 4B
T12829 19355-19356 -RRB- denotes )
T12830 19356-19358 , denotes ,
T12831 19358-19368 VBN denotes determined
T12832 19369-19371 IN denotes as
T12833 19372-19375 DT denotes the
T12834 19376-19380 NN denotes time
T12835 19381-19388 IN denotes between
T12836 19389-19397 NN denotes bleeding
T12837 19398-19407 NN denotes cessation
T12838 19408-19411 CC denotes and
T12839 19412-19422 NN denotes initiation
T12840 19423-19425 IN denotes of
T12841 19426-19429 DT denotes the
T12843 19430-19436 JJ denotes second
T12842 19437-19445 NN denotes bleeding
T12844 19445-19447 , denotes ,
T12845 19447-19450 VBD denotes was
T12846 19451-19459 RB denotes markedly
T12825 19460-19469 VBN denotes increased
T12847 19470-19472 IN denotes in
T12848 19473-19476 DT denotes the
T12850 19477-19478 NN denotes A
T12852 19478-19479 HYPH denotes /
T12851 19479-19480 NN denotes J
T12849 19481-19485 NNS denotes mice
T12853 19486-19494 VBN denotes compared
T12854 19495-19497 IN denotes to
T12855 19498-19501 DT denotes the
T12857 19502-19504 NN denotes B6
T12856 19505-19509 NNS denotes mice
T12858 19510-19513 CC denotes and
T12859 19514-19517 CD denotes two
T12860 19518-19525 NNS denotes strains
T12862 19525-19527 , denotes ,
T12863 19527-19529 NN denotes B6
T12865 19529-19530 HYPH denotes -
T12864 19530-19536 NN denotes Chr11A
T12867 19536-19537 HYPH denotes /
T12866 19537-19538 NN denotes J
T12868 19539-19540 -LRB- denotes (
T12869 19540-19543 NN denotes CSS
T12870 19543-19544 HYPH denotes -
T12871 19544-19546 CD denotes 11
T12872 19546-19547 -RRB- denotes )
T12873 19548-19551 CC denotes and
T12874 19552-19554 NN denotes B6
T12876 19554-19555 HYPH denotes -
T12875 19555-19561 NN denotes Chr17A
T12878 19561-19562 HYPH denotes /
T12877 19562-19563 NN denotes J
T12879 19564-19565 -LRB- denotes (
T12880 19565-19568 NN denotes CSS
T12881 19568-19569 HYPH denotes -
T12882 19569-19571 CD denotes 17
T12883 19571-19572 -RRB- denotes )
T12884 19572-19574 , denotes ,
T12861 19574-19577 VBD denotes had
T12885 19578-19591 RB denotes significantly
T12887 19592-19593 -LRB- denotes (
T12889 19593-19594 NN denotes P
T12890 19595-19596 SYM denotes <
T12888 19597-19602 CD denotes 0.002
T12891 19602-19603 -RRB- denotes )
T12886 19604-19610 JJR denotes longer
T12893 19611-19621 NN denotes rebleeding
T12892 19622-19627 NNS denotes times
T12894 19628-19636 VBN denotes compared
T12895 19637-19639 IN denotes to
T12896 19640-19643 DT denotes the
T12898 19644-19646 NN denotes B6
T12897 19647-19651 NNS denotes mice
T12899 19652-19656 WDT denotes that
T12900 19657-19661 VBD denotes were
T12901 19662-19669 JJ denotes similar
T12902 19670-19672 IN denotes to
T12903 19673-19679 NNS denotes values
T12904 19680-19684 IN denotes from
T12905 19685-19688 DT denotes the
T12907 19689-19690 NN denotes A
T12909 19690-19691 HYPH denotes /
T12908 19691-19692 NN denotes J
T12906 19693-19697 NNS denotes mice
T12910 19697-19698 . denotes .
T12911 19698-19772 sentence denotes Another strain, B6-Chr5A/J (CSS-5), approached significance at P < 0.008.
T12912 19699-19706 DT denotes Another
T12913 19707-19713 NN denotes strain
T12915 19713-19715 , denotes ,
T12916 19715-19717 NN denotes B6
T12918 19717-19718 HYPH denotes -
T12917 19718-19723 NN denotes Chr5A
T12920 19723-19724 HYPH denotes /
T12919 19724-19725 NN denotes J
T12921 19726-19727 -LRB- denotes (
T12922 19727-19730 NN denotes CSS
T12923 19730-19731 HYPH denotes -
T12924 19731-19732 CD denotes 5
T12925 19732-19733 -RRB- denotes )
T12926 19733-19735 , denotes ,
T12914 19735-19745 VBN denotes approached
T12927 19746-19758 NN denotes significance
T12928 19759-19761 IN denotes at
T12929 19762-19763 NN denotes P
T12930 19764-19765 SYM denotes <
T12931 19766-19771 CD denotes 0.008
T12932 19771-19772 . denotes .
T12933 19772-19932 sentence denotes The rebleeding time was stopped at 600 sec, and the percentage of mice with this value determined for the three strains: CSS-5–60%, CSS-11–60% and CSS-A17–46%.
T12934 19773-19776 DT denotes The
T12936 19777-19787 NN denotes rebleeding
T12935 19788-19792 NN denotes time
T12938 19793-19796 VBD denotes was
T12937 19797-19804 VBN denotes stopped
T12939 19805-19807 IN denotes at
T12940 19808-19811 CD denotes 600
T12941 19812-19815 NN denotes sec
T12942 19815-19817 , denotes ,
T12943 19817-19820 CC denotes and
T12944 19821-19824 DT denotes the
T12945 19825-19835 NN denotes percentage
T12947 19836-19838 IN denotes of
T12948 19839-19843 NNS denotes mice
T12949 19844-19848 IN denotes with
T12950 19849-19853 DT denotes this
T12951 19854-19859 NN denotes value
T12946 19860-19870 VBN denotes determined
T12952 19871-19874 IN denotes for
T12953 19875-19878 DT denotes the
T12955 19879-19884 CD denotes three
T12954 19885-19892 NNS denotes strains
T12956 19892-19894 : denotes :
T12957 19894-19897 NN denotes CSS
T12959 19897-19898 HYPH denotes -
T12960 19898-19899 CD denotes 5
T12961 19899-19900 : denotes –
T12962 19900-19902 CD denotes 60
T12958 19902-19903 NN denotes %
T12963 19903-19905 , denotes ,
T12964 19905-19908 NN denotes CSS
T12966 19908-19909 HYPH denotes -
T12967 19909-19911 CD denotes 11
T12968 19911-19912 : denotes –
T12969 19912-19914 NN denotes 60
T12965 19914-19915 NN denotes %
T12970 19916-19919 CC denotes and
T12971 19920-19923 NN denotes CSS
T12973 19923-19924 HYPH denotes -
T12972 19924-19927 NN denotes A17
T12975 19927-19928 : denotes –
T12976 19928-19930 CD denotes 46
T12974 19930-19931 NN denotes %
T12977 19931-19932 . denotes .
T12978 19932-20044 sentence denotes The percentage of B6 mice with a rebleeding time of 600 sec was 7% and for the A/J mice the percentage was 85%.
T12979 19933-19936 DT denotes The
T12980 19937-19947 NN denotes percentage
T12982 19948-19950 IN denotes of
T12983 19951-19953 NN denotes B6
T12984 19954-19958 NNS denotes mice
T12985 19959-19963 IN denotes with
T12986 19964-19965 DT denotes a
T12988 19966-19976 NN denotes rebleeding
T12987 19977-19981 NN denotes time
T12989 19982-19984 IN denotes of
T12990 19985-19988 CD denotes 600
T12991 19989-19992 NN denotes sec
T12981 19993-19996 VBD denotes was
T12992 19997-19998 CD denotes 7
T12993 19998-19999 NN denotes %
T12994 20000-20003 CC denotes and
T12995 20004-20007 IN denotes for
T12997 20008-20011 DT denotes the
T12999 20012-20013 NN denotes A
T13001 20013-20014 HYPH denotes /
T13000 20014-20015 NN denotes J
T12998 20016-20020 NNS denotes mice
T13002 20021-20024 DT denotes the
T13003 20025-20035 NN denotes percentage
T12996 20036-20039 VBD denotes was
T13004 20040-20042 CD denotes 85
T13005 20042-20043 NN denotes %
T13006 20043-20044 . denotes .
T13007 20044-20664 sentence denotes Figure 4 Bleeding and rebleeding time in the CSS. Panel A: Bleeding Time (seconds). Panel B: Rebleeding Time (seconds). Bars are the mean ± SEM of 7–28 mice. Statistical differences between B6 mice and CSS were determined with a t-test, and a Bonferroni correction was made to determine significance value (P < 0.002). Symbols indicate a significant difference between B6 values. *P < 0.002. Rebleeding time in the parent strains and CSS were compared to values from the progeny of mice that were crossed with B6 mice to produce heterosomic mice for the CSS-5, (B6xCSS-5)F1 and CSS-17 (B6xCSS-17)F1 strains (Figure 5).
T21929 20055-20063 NN denotes Bleeding
T21931 20064-20067 CC denotes and
T21932 20068-20078 NN denotes rebleeding
T21930 20079-20083 NN denotes time
T21933 20084-20086 IN denotes in
T21934 20087-20090 DT denotes the
T21935 20091-20094 NN denotes CSS
T21936 20094-20095 . denotes .
T21937 20095-20129 sentence denotes Panel A: Bleeding Time (seconds).
T21938 20096-20101 NN denotes Panel
T21939 20102-20103 NN denotes A
T21940 20103-20105 : denotes :
T21941 20105-20113 NN denotes Bleeding
T21942 20114-20118 NN denotes Time
T21943 20119-20120 -LRB- denotes (
T21944 20120-20127 NNS denotes seconds
T21945 20127-20128 -RRB- denotes )
T21946 20128-20129 . denotes .
T21947 20129-20165 sentence denotes Panel B: Rebleeding Time (seconds).
T21948 20130-20135 NN denotes Panel
T21949 20136-20137 NN denotes B
T21950 20137-20139 : denotes :
T21951 20139-20149 NN denotes Rebleeding
T21952 20150-20154 NN denotes Time
T21953 20155-20156 -LRB- denotes (
T21954 20156-20163 NNS denotes seconds
T21955 20163-20164 -RRB- denotes )
T21956 20164-20165 . denotes .
T21957 20165-20203 sentence denotes Bars are the mean ± SEM of 7–28 mice.
T21958 20166-20170 NNS denotes Bars
T21959 20171-20174 VBP denotes are
T21960 20175-20178 DT denotes the
T21962 20179-20183 NN denotes mean
T21963 20184-20185 SYM denotes ±
T21961 20186-20189 NN denotes SEM
T21964 20190-20192 IN denotes of
T21965 20193-20194 CD denotes 7
T21967 20194-20195 SYM denotes –
T21966 20195-20197 CD denotes 28
T21968 20198-20202 NNS denotes mice
T21969 20202-20203 . denotes .
T21970 20203-20364 sentence denotes Statistical differences between B6 mice and CSS were determined with a t-test, and a Bonferroni correction was made to determine significance value (P < 0.002).
T21971 20204-20215 JJ denotes Statistical
T21972 20216-20227 NNS denotes differences
T21974 20228-20235 IN denotes between
T21975 20236-20238 NN denotes B6
T21976 20239-20243 NNS denotes mice
T21977 20244-20247 CC denotes and
T21978 20248-20251 NN denotes CSS
T21979 20252-20256 VBD denotes were
T21973 20257-20267 VBN denotes determined
T21980 20268-20272 IN denotes with
T21981 20273-20274 DT denotes a
T21983 20275-20276 NN denotes t
T21984 20276-20277 HYPH denotes -
T21982 20277-20281 NN denotes test
T21985 20281-20283 , denotes ,
T21986 20283-20286 CC denotes and
T21987 20287-20288 DT denotes a
T21989 20289-20299 NNP denotes Bonferroni
T21988 20300-20310 NN denotes correction
T21991 20311-20314 VBD denotes was
T21990 20315-20319 VBN denotes made
T21992 20320-20322 TO denotes to
T21993 20323-20332 VB denotes determine
T21994 20333-20345 NN denotes significance
T21995 20346-20351 NN denotes value
T21996 20352-20353 -LRB- denotes (
T21998 20353-20354 NN denotes P
T21999 20355-20356 SYM denotes <
T21997 20357-20362 CD denotes 0.002
T22000 20362-20363 -RRB- denotes )
T22001 20363-20364 . denotes .
T22002 20364-20425 sentence denotes Symbols indicate a significant difference between B6 values.
T22003 20365-20372 NNS denotes Symbols
T22004 20373-20381 VBP denotes indicate
T22005 20382-20383 DT denotes a
T22007 20384-20395 JJ denotes significant
T22006 20396-20406 NN denotes difference
T22008 20407-20414 IN denotes between
T22009 20415-20417 NN denotes B6
T22010 20418-20424 NNS denotes values
T22011 20424-20425 . denotes .
T22012 20425-20437 sentence denotes *P < 0.002.
T22013 20426-20427 SYM denotes *
T22014 20427-20428 NN denotes P
T22016 20429-20430 SYM denotes <
T22015 20431-20436 CD denotes 0.002
T22017 20436-20437 . denotes .
T13008 20438-20448 NN denotes Rebleeding
T13009 20449-20453 NN denotes time
T13011 20454-20456 IN denotes in
T13012 20457-20460 DT denotes the
T13014 20461-20467 NN denotes parent
T13013 20468-20475 NNS denotes strains
T13015 20476-20479 CC denotes and
T13016 20480-20483 NN denotes CSS
T13017 20484-20488 VBD denotes were
T13010 20489-20497 VBN denotes compared
T13018 20498-20500 IN denotes to
T13019 20501-20507 NNS denotes values
T13020 20508-20512 IN denotes from
T13021 20513-20516 DT denotes the
T13022 20517-20524 NN denotes progeny
T13023 20525-20527 IN denotes of
T13024 20528-20532 NNS denotes mice
T13025 20533-20537 WDT denotes that
T13027 20538-20542 VBD denotes were
T13026 20543-20550 VBN denotes crossed
T13028 20551-20555 IN denotes with
T13029 20556-20558 NN denotes B6
T13030 20559-20563 NNS denotes mice
T13031 20564-20566 TO denotes to
T13032 20567-20574 VB denotes produce
T13033 20575-20586 JJ denotes heterosomic
T13034 20587-20591 NNS denotes mice
T13035 20592-20595 IN denotes for
T13036 20596-20599 DT denotes the
T13038 20600-20603 NN denotes CSS
T13040 20603-20604 HYPH denotes -
T13041 20604-20605 CD denotes 5
T13042 20605-20607 , denotes ,
T13043 20607-20608 -LRB- denotes (
T13044 20608-20614 NN denotes B6xCSS
T13045 20614-20615 HYPH denotes -
T13046 20615-20616 CD denotes 5
T13047 20616-20617 -RRB- denotes )
T13039 20617-20619 NN denotes F1
T13048 20620-20623 CC denotes and
T13049 20624-20627 NN denotes CSS
T13051 20627-20628 HYPH denotes -
T13052 20628-20630 CD denotes 17
T13053 20631-20632 -LRB- denotes (
T13054 20632-20638 NN denotes B6xCSS
T13055 20638-20639 HYPH denotes -
T13056 20639-20641 CD denotes 17
T13057 20641-20642 -RRB- denotes )
T13050 20642-20644 NN denotes F1
T13037 20645-20652 NNS denotes strains
T13058 20653-20654 -LRB- denotes (
T13059 20654-20660 NN denotes Figure
T13060 20661-20662 CD denotes 5
T13061 20662-20663 -RRB- denotes )
T13062 20663-20664 . denotes .
T13063 20664-20804 sentence denotes The rebleeding values for CSS-5F1 and CSS-17F1 mice were similar to the B6 rather than the A/J mice, suggesting the A/J trait is recessive.
T13064 20665-20668 DT denotes The
T13066 20669-20679 NN denotes rebleeding
T13065 20680-20686 NNS denotes values
T13068 20687-20690 IN denotes for
T13069 20691-20694 NN denotes CSS
T13071 20694-20695 HYPH denotes -
T13070 20695-20698 NN denotes 5F1
T13073 20699-20702 CC denotes and
T13074 20703-20706 NN denotes CSS
T13076 20706-20707 HYPH denotes -
T13075 20707-20711 NN denotes 17F1
T13072 20712-20716 NNS denotes mice
T13067 20717-20721 VBD denotes were
T13077 20722-20729 JJ denotes similar
T13078 20730-20732 IN denotes to
T13079 20733-20736 DT denotes the
T13080 20737-20739 NN denotes B6
T13081 20740-20746 RB denotes rather
T13082 20747-20751 IN denotes than
T13083 20752-20755 DT denotes the
T13085 20756-20757 NN denotes A
T13086 20757-20758 HYPH denotes /
T13084 20758-20759 NN denotes J
T13087 20760-20764 NNS denotes mice
T13088 20764-20766 , denotes ,
T13089 20766-20776 VBG denotes suggesting
T13090 20777-20780 DT denotes the
T13092 20781-20782 NN denotes A
T13094 20782-20783 HYPH denotes /
T13093 20783-20784 NN denotes J
T13091 20785-20790 NN denotes trait
T13095 20791-20793 VBZ denotes is
T13096 20794-20803 JJ denotes recessive
T13097 20803-20804 . denotes .
T13098 20804-20997 sentence denotes Bleeding and rebleeding in the progeny of the cross, B6-Chr5A/J × B6-Chr17A/J (CSS-5 × CSS-17) resulted in the recovery of the A/J phenotype in the progeny of these double heterosomic strains.
T13099 20805-20813 NN denotes Bleeding
T13101 20814-20817 CC denotes and
T13102 20818-20828 NN denotes rebleeding
T13103 20829-20831 IN denotes in
T13104 20832-20835 DT denotes the
T13105 20836-20843 NN denotes progeny
T13106 20844-20846 IN denotes of
T13107 20847-20850 DT denotes the
T13108 20851-20856 NN denotes cross
T13109 20856-20858 , denotes ,
T13110 20858-20860 NN denotes B6
T13112 20860-20861 HYPH denotes -
T13113 20861-20866 NN denotes Chr5A
T13114 20866-20867 HYPH denotes /
T13111 20867-20868 NN denotes J
T13115 20869-20870 SYM denotes ×
T13116 20871-20873 NN denotes B6
T13118 20873-20874 HYPH denotes -
T13119 20874-20880 NN denotes Chr17A
T13120 20880-20881 HYPH denotes /
T13117 20881-20882 NN denotes J
T13121 20883-20884 -LRB- denotes (
T13122 20884-20887 NN denotes CSS
T13123 20887-20888 HYPH denotes -
T13124 20888-20889 CD denotes 5
T13125 20890-20891 SYM denotes ×
T13126 20892-20895 NN denotes CSS
T13127 20895-20896 HYPH denotes -
T13128 20896-20898 CD denotes 17
T13129 20898-20899 -RRB- denotes )
T13100 20900-20908 VBD denotes resulted
T13130 20909-20911 IN denotes in
T13131 20912-20915 DT denotes the
T13132 20916-20924 NN denotes recovery
T13133 20925-20927 IN denotes of
T13134 20928-20931 DT denotes the
T13136 20932-20933 NN denotes A
T13138 20933-20934 HYPH denotes /
T13137 20934-20935 NN denotes J
T13135 20936-20945 NN denotes phenotype
T13139 20946-20948 IN denotes in
T13140 20949-20952 DT denotes the
T13141 20953-20960 NN denotes progeny
T13142 20961-20963 IN denotes of
T13143 20964-20969 DT denotes these
T13145 20970-20976 JJ denotes double
T13146 20977-20988 JJ denotes heterosomic
T13144 20989-20996 NNS denotes strains
T13147 20996-20997 . denotes .
T13148 20997-21127 sentence denotes Thus, despite the heterosomic chromosomes of 5 and 17 in the progeny of the CSS-5 × CSS-17, the phenotype was now similar to A/J.
T13149 20998-21002 RB denotes Thus
T13151 21002-21004 , denotes ,
T13152 21004-21011 IN denotes despite
T13153 21012-21015 DT denotes the
T13155 21016-21027 JJ denotes heterosomic
T13154 21028-21039 NNS denotes chromosomes
T13156 21040-21042 IN denotes of
T13157 21043-21044 CD denotes 5
T13158 21045-21048 CC denotes and
T13159 21049-21051 CD denotes 17
T13160 21052-21054 IN denotes in
T13161 21055-21058 DT denotes the
T13162 21059-21066 NN denotes progeny
T13163 21067-21069 IN denotes of
T13164 21070-21073 DT denotes the
T13165 21074-21077 NN denotes CSS
T13166 21077-21078 HYPH denotes -
T13167 21078-21079 CD denotes 5
T13168 21080-21081 SYM denotes ×
T13169 21082-21085 NN denotes CSS
T13170 21085-21086 HYPH denotes -
T13171 21086-21088 CD denotes 17
T13172 21088-21090 , denotes ,
T13173 21090-21093 DT denotes the
T13174 21094-21103 NN denotes phenotype
T13150 21104-21107 VBD denotes was
T13175 21108-21111 RB denotes now
T13176 21112-21119 JJ denotes similar
T13177 21120-21122 IN denotes to
T13178 21123-21124 NN denotes A
T13180 21124-21125 HYPH denotes /
T13179 21125-21126 NN denotes J
T13181 21126-21127 . denotes .
T13182 21127-21220 sentence denotes This suggested that traits on the A/J chromosomes were interacting to produce the phenotype.
T13183 21128-21132 DT denotes This
T13184 21133-21142 VBD denotes suggested
T13185 21143-21147 IN denotes that
T13187 21148-21154 NNS denotes traits
T13188 21155-21157 IN denotes on
T13189 21158-21161 DT denotes the
T13191 21162-21163 NN denotes A
T13193 21163-21164 HYPH denotes /
T13192 21164-21165 NN denotes J
T13190 21166-21177 NNS denotes chromosomes
T13194 21178-21182 VBD denotes were
T13186 21183-21194 VBG denotes interacting
T13195 21195-21197 TO denotes to
T13196 21198-21205 VB denotes produce
T13197 21206-21209 DT denotes the
T13198 21210-21219 NN denotes phenotype
T13199 21219-21220 . denotes .
T22254 21231-21239 NN denotes Bleeding
T22256 21240-21243 CC denotes and
T22257 21244-21254 NN denotes rebleeding
T22255 21255-21259 NN denotes time
T22258 21260-21262 IN denotes in
T22259 21263-21266 DT denotes the
T22261 21267-21270 NN denotes CSS
T22260 21271-21282 NNS denotes backcrosses
T22262 21282-21283 . denotes .
T22263 21283-21495 sentence denotes Panel A: Bleeding Time (seconds) and Panel B: Rebleeding Time (seconds) were tested in heterosomic mice, (B6xCSS-5)F1 (5F1) and (B6xCSS-17)F1 (17F1) and doubly heterosomic mice for chromosomes 5 and 17 (5 × 17).
T22264 21284-21289 NN denotes Panel
T22265 21290-21291 NN denotes A
T22267 21291-21293 : denotes :
T22268 21293-21301 NN denotes Bleeding
T22269 21302-21306 NN denotes Time
T22270 21307-21308 -LRB- denotes (
T22271 21308-21315 NNS denotes seconds
T22272 21315-21316 -RRB- denotes )
T22273 21317-21320 CC denotes and
T22274 21321-21326 NN denotes Panel
T22275 21327-21328 NN denotes B
T22276 21328-21330 : denotes :
T22277 21330-21340 NN denotes Rebleeding
T22278 21341-21345 NN denotes Time
T22279 21346-21347 -LRB- denotes (
T22280 21347-21354 NNS denotes seconds
T22281 21354-21355 -RRB- denotes )
T22282 21356-21360 VBD denotes were
T22266 21361-21367 VBN denotes tested
T22283 21368-21370 IN denotes in
T22284 21371-21382 JJ denotes heterosomic
T22285 21383-21387 NNS denotes mice
T22286 21387-21389 , denotes ,
T22287 21389-21390 -LRB- denotes (
T22289 21390-21396 NN denotes B6xCSS
T22290 21396-21397 HYPH denotes -
T22291 21397-21398 CD denotes 5
T22292 21398-21399 -RRB- denotes )
T22288 21399-21401 NN denotes F1
T22293 21402-21403 -LRB- denotes (
T22294 21403-21406 NN denotes 5F1
T22295 21406-21407 -RRB- denotes )
T22296 21408-21411 CC denotes and
T22297 21412-21413 -LRB- denotes (
T22299 21413-21419 NN denotes B6xCSS
T22300 21419-21420 HYPH denotes -
T22301 21420-21422 CD denotes 17
T22302 21422-21423 -RRB- denotes )
T22298 21423-21425 NN denotes F1
T22303 21426-21427 -LRB- denotes (
T22304 21427-21431 NN denotes 17F1
T22305 21431-21432 -RRB- denotes )
T22306 21433-21436 CC denotes and
T22307 21437-21443 RB denotes doubly
T22308 21444-21455 JJ denotes heterosomic
T22309 21456-21460 NNS denotes mice
T22310 21461-21464 IN denotes for
T22311 21465-21476 NNS denotes chromosomes
T22312 21477-21478 CD denotes 5
T22313 21479-21482 CC denotes and
T22314 21483-21485 CD denotes 17
T22315 21486-21487 -LRB- denotes (
T22316 21487-21488 CD denotes 5
T22318 21489-21490 SYM denotes ×
T22317 21491-21493 CD denotes 17
T22319 21493-21494 -RRB- denotes )
T22320 21494-21495 . denotes .
T22321 21495-21533 sentence denotes Bars are the mean ± SEM of 5–28 mice.
T22322 21496-21500 NNS denotes Bars
T22323 21501-21504 VBP denotes are
T22324 21505-21508 DT denotes the
T22326 21509-21513 NN denotes mean
T22327 21514-21515 SYM denotes ±
T22325 21516-21519 NN denotes SEM
T22328 21520-21522 IN denotes of
T22329 21523-21524 CD denotes 5
T22331 21524-21525 SYM denotes –
T22332 21525-21526 CD denotes 2
T22330 21526-21527 CD denotes 8
T22333 21528-21532 NNS denotes mice
T22334 21532-21533 . denotes .
T22335 21533-21697 sentence denotes Statistical differences between B6 mice and the CSS were determined with a t-test, and a Bonferroni correction was made to determine significance value (P < 0.01).
T22336 21534-21545 JJ denotes Statistical
T22337 21546-21557 NNS denotes differences
T22339 21558-21565 IN denotes between
T22340 21566-21568 NN denotes B6
T22341 21569-21573 NNS denotes mice
T22342 21574-21577 CC denotes and
T22343 21578-21581 DT denotes the
T22344 21582-21585 NN denotes CSS
T22345 21586-21590 VBD denotes were
T22338 21591-21601 VBN denotes determined
T22346 21602-21606 IN denotes with
T22347 21607-21608 DT denotes a
T22349 21609-21610 NN denotes t
T22350 21610-21611 HYPH denotes -
T22348 21611-21615 NN denotes test
T22351 21615-21617 , denotes ,
T22352 21617-21620 CC denotes and
T22353 21621-21622 DT denotes a
T22355 21623-21633 NNP denotes Bonferroni
T22354 21634-21644 NN denotes correction
T22357 21645-21648 VBD denotes was
T22356 21649-21653 VBN denotes made
T22358 21654-21656 TO denotes to
T22359 21657-21666 VB denotes determine
T22360 21667-21679 NN denotes significance
T22361 21680-21685 NN denotes value
T22362 21686-21687 -LRB- denotes (
T22364 21687-21688 NN denotes P
T22365 21689-21690 SYM denotes <
T22363 21691-21695 CD denotes 0.01
T22366 21695-21696 -RRB- denotes )
T22367 21696-21697 . denotes .
T22368 21697-21758 sentence denotes Symbols indicate a significant difference between B6 values.
T22369 21698-21705 NNS denotes Symbols
T22370 21706-21714 VBP denotes indicate
T22371 21715-21716 DT denotes a
T22373 21717-21728 JJ denotes significant
T22372 21729-21739 NN denotes difference
T22374 21740-21747 IN denotes between
T22375 21748-21750 NN denotes B6
T22376 21751-21757 NNS denotes values
T22377 21757-21758 . denotes .
T22378 21758-21769 sentence denotes *P < 0.01.
T22379 21759-21760 SYM denotes *
T22381 21760-21761 NN denotes P
T22382 21762-21763 SYM denotes <
T22380 21764-21768 CD denotes 0.01
T22383 21768-21769 . denotes .
T14099 21771-21783 NNS denotes Interactions
T14100 21784-21786 IN denotes of
T14101 21787-21790 NN denotes CSS
T14102 21791-21794 IN denotes for
T14103 21795-21798 NN denotes PAI
T14104 21798-21799 HYPH denotes -
T14105 21799-21800 CD denotes 1
T14106 21801-21808 NN denotes antigen
T14107 21809-21812 CC denotes and
T14108 21813-21821 NN denotes activity
T14109 21821-21930 sentence denotes Components of the Plg system reside on chromosomes CSS-5 (PAI-1), CSS-11 (α2-antiplasmin), and CSS-17 (Plg).
T14110 21822-21832 NNS denotes Components
T14112 21833-21835 IN denotes of
T14113 21836-21839 DT denotes the
T14115 21840-21843 NN denotes Plg
T14114 21844-21850 NN denotes system
T14111 21851-21857 VBP denotes reside
T14116 21858-21860 IN denotes on
T14117 21861-21872 NNS denotes chromosomes
T14118 21873-21876 NN denotes CSS
T14119 21876-21877 HYPH denotes -
T14120 21877-21878 CD denotes 5
T14121 21879-21880 -LRB- denotes (
T14122 21880-21883 NN denotes PAI
T14123 21883-21884 HYPH denotes -
T14124 21884-21885 CD denotes 1
T14125 21885-21886 -RRB- denotes )
T14126 21886-21888 , denotes ,
T14127 21888-21891 NN denotes CSS
T14128 21891-21892 HYPH denotes -
T14129 21892-21894 CD denotes 11
T14130 21895-21896 -LRB- denotes (
T14131 21896-21898 NN denotes α2
T14133 21898-21899 HYPH denotes -
T14132 21899-21910 NN denotes antiplasmin
T14134 21910-21911 -RRB- denotes )
T14135 21911-21913 , denotes ,
T14136 21913-21916 CC denotes and
T14137 21917-21920 NN denotes CSS
T14138 21920-21921 HYPH denotes -
T14139 21921-21923 CD denotes 17
T14140 21924-21925 -LRB- denotes (
T14141 21925-21928 NN denotes Plg
T14142 21928-21929 -RRB- denotes )
T14143 21929-21930 . denotes .
T14144 21930-22089 sentence denotes As reported in Table 2, the A/J mice had increased Plg antigen, fibrinolytic activity, α2-antiplasmin, PAI-1 activity and fibrinogen when compared to B6 mice.
T14145 21931-21933 IN denotes As
T14146 21934-21942 VBN denotes reported
T14148 21943-21945 IN denotes in
T14149 21946-21951 NN denotes Table
T14150 21952-21953 CD denotes 2
T14151 21953-21955 , denotes ,
T14152 21955-21958 DT denotes the
T14154 21959-21960 NN denotes A
T14156 21960-21961 HYPH denotes /
T14155 21961-21962 NN denotes J
T14153 21963-21967 NNS denotes mice
T14147 21968-21971 VBD denotes had
T14157 21972-21981 VBN denotes increased
T14159 21982-21985 NN denotes Plg
T14158 21986-21993 NN denotes antigen
T14160 21993-21995 , denotes ,
T14161 21995-22007 JJ denotes fibrinolytic
T14162 22008-22016 NN denotes activity
T14163 22016-22018 , denotes ,
T14164 22018-22020 NN denotes α2
T14166 22020-22021 HYPH denotes -
T14165 22021-22032 NN denotes antiplasmin
T14167 22032-22034 , denotes ,
T14168 22034-22037 NN denotes PAI
T14170 22037-22038 HYPH denotes -
T14171 22038-22039 CD denotes 1
T14169 22040-22048 NN denotes activity
T14172 22049-22052 CC denotes and
T14173 22053-22063 NN denotes fibrinogen
T14174 22064-22068 WRB denotes when
T14175 22069-22077 VBN denotes compared
T14176 22078-22080 IN denotes to
T14177 22081-22083 NN denotes B6
T14178 22084-22088 NNS denotes mice
T14179 22088-22089 . denotes .
T14180 22089-22299 sentence denotes In CSS-17 mice, the Plg antigen was also significantly (P = 0.015) increased (152 ± 6, n = 12) when compared to the B6 mice, but for CSS-5 and CSS-5 × 17, the Plg antigen was similar to values for the B6 mice.
T14181 22090-22092 IN denotes In
T14183 22093-22096 NN denotes CSS
T14185 22096-22097 HYPH denotes -
T14186 22097-22099 CD denotes 17
T14184 22100-22104 NNS denotes mice
T14187 22104-22106 , denotes ,
T14188 22106-22109 DT denotes the
T14190 22110-22113 NN denotes Plg
T14189 22114-22121 NN denotes antigen
T14182 22122-22125 VBD denotes was
T14191 22126-22130 RB denotes also
T14192 22131-22144 RB denotes significantly
T14194 22145-22146 -LRB- denotes (
T14196 22146-22147 NN denotes P
T14197 22148-22149 SYM denotes =
T14195 22150-22155 CD denotes 0.015
T14198 22155-22156 -RRB- denotes )
T14193 22157-22166 JJ denotes increased
T14199 22167-22168 -LRB- denotes (
T14201 22168-22171 CD denotes 152
T14202 22172-22173 SYM denotes ±
T14200 22174-22175 CD denotes 6
T14203 22175-22177 , denotes ,
T14204 22177-22178 NN denotes n
T14206 22179-22180 SYM denotes =
T14205 22181-22183 CD denotes 12
T14207 22183-22184 -RRB- denotes )
T14208 22185-22189 WRB denotes when
T14209 22190-22198 VBN denotes compared
T14210 22199-22201 IN denotes to
T14211 22202-22205 DT denotes the
T14213 22206-22208 NN denotes B6
T14212 22209-22213 NNS denotes mice
T14214 22213-22215 , denotes ,
T14215 22215-22218 CC denotes but
T14216 22219-22222 IN denotes for
T14218 22223-22226 NN denotes CSS
T14219 22226-22227 HYPH denotes -
T14220 22227-22228 CD denotes 5
T14221 22229-22232 CC denotes and
T14222 22233-22236 NN denotes CSS
T14223 22236-22237 HYPH denotes -
T14224 22237-22238 CD denotes 5
T14225 22239-22240 SYM denotes ×
T14226 22241-22243 CD denotes 17
T14227 22243-22245 , denotes ,
T14228 22245-22248 DT denotes the
T14230 22249-22252 NN denotes Plg
T14229 22253-22260 NN denotes antigen
T14217 22261-22264 VBD denotes was
T14231 22265-22272 JJ denotes similar
T14232 22273-22275 IN denotes to
T14233 22276-22282 NNS denotes values
T14234 22283-22286 IN denotes for
T14235 22287-22290 DT denotes the
T14237 22291-22293 NN denotes B6
T14236 22294-22298 NNS denotes mice
T14238 22298-22299 . denotes .
T14239 22299-22395 sentence denotes Fibrinolytic activity was not different in the CSS-5 or CSS-17 strains compared to the B6 mice.
T14240 22300-22312 JJ denotes Fibrinolytic
T14241 22313-22321 NN denotes activity
T14242 22322-22325 VBD denotes was
T14243 22326-22329 RB denotes not
T14244 22330-22339 JJ denotes different
T14245 22340-22342 IN denotes in
T14246 22343-22346 DT denotes the
T14248 22347-22350 NN denotes CSS
T14249 22350-22351 HYPH denotes -
T14250 22351-22352 CD denotes 5
T14251 22353-22355 CC denotes or
T14252 22356-22359 NN denotes CSS
T14253 22359-22360 HYPH denotes -
T14254 22360-22362 CD denotes 17
T14247 22363-22370 NNS denotes strains
T14255 22371-22379 VBN denotes compared
T14256 22380-22382 IN denotes to
T14257 22383-22386 DT denotes the
T14259 22387-22389 NN denotes B6
T14258 22390-22394 NNS denotes mice
T14260 22394-22395 . denotes .
T14261 22395-22623 sentence denotes α2-antiplasmin was significantly (P = < 0.01) reduced in CSS-5 mice (142 ± 4 μg/mL, n = 5), significantly (P < 0.05) higher in the CSS-11 (201 ± 6, n = 8), but not different in CSS-17 or CSS-5 × 17 mice compared to the B6 mice.
T14262 22396-22398 NN denotes α2
T14264 22398-22399 HYPH denotes -
T14263 22399-22410 NN denotes antiplasmin
T14265 22411-22414 VBD denotes was
T14266 22415-22428 RB denotes significantly
T14268 22429-22430 -LRB- denotes (
T14270 22430-22431 NN denotes P
T14271 22432-22433 SYM denotes =
T14272 22434-22435 SYM denotes <
T14269 22436-22440 CD denotes 0.01
T14273 22440-22441 -RRB- denotes )
T14267 22442-22449 JJ denotes reduced
T14274 22450-22452 IN denotes in
T14275 22453-22456 NN denotes CSS
T14277 22456-22457 HYPH denotes -
T14278 22457-22458 CD denotes 5
T14276 22459-22463 NNS denotes mice
T14279 22464-22465 -LRB- denotes (
T14281 22465-22468 CD denotes 142
T14283 22469-22470 SYM denotes ±
T14282 22471-22472 CD denotes 4
T14280 22473-22475 NNS denotes μg
T14284 22475-22476 SYM denotes /
T14285 22476-22478 NN denotes mL
T14286 22478-22480 , denotes ,
T14287 22480-22481 NN denotes n
T14289 22482-22483 SYM denotes =
T14288 22484-22485 CD denotes 5
T14290 22485-22486 -RRB- denotes )
T14291 22486-22488 , denotes ,
T14292 22488-22501 RB denotes significantly
T14294 22502-22503 -LRB- denotes (
T14296 22503-22504 NN denotes P
T14297 22505-22506 SYM denotes <
T14295 22507-22511 CD denotes 0.05
T14298 22511-22512 -RRB- denotes )
T14293 22513-22519 JJR denotes higher
T14299 22520-22522 IN denotes in
T14300 22523-22526 DT denotes the
T14301 22527-22530 NN denotes CSS
T14302 22530-22531 HYPH denotes -
T14303 22531-22533 CD denotes 11
T14304 22534-22535 -LRB- denotes (
T14306 22535-22538 CD denotes 201
T14307 22539-22540 SYM denotes ±
T14305 22541-22542 CD denotes 6
T14308 22542-22544 , denotes ,
T14309 22544-22545 NN denotes n
T14311 22546-22547 SYM denotes =
T14310 22548-22549 CD denotes 8
T14312 22549-22550 -RRB- denotes )
T14313 22550-22552 , denotes ,
T14314 22552-22555 CC denotes but
T14315 22556-22559 RB denotes not
T14316 22560-22569 JJ denotes different
T14317 22570-22572 IN denotes in
T14318 22573-22576 NN denotes CSS
T14320 22576-22577 HYPH denotes -
T14321 22577-22579 CD denotes 17
T14322 22580-22582 CC denotes or
T14323 22583-22586 NN denotes CSS
T14324 22586-22587 HYPH denotes -
T14325 22587-22588 CD denotes 5
T14326 22589-22590 SYM denotes ×
T14327 22591-22593 CD denotes 17
T14319 22594-22598 NNS denotes mice
T14328 22599-22607 VBN denotes compared
T14329 22608-22610 IN denotes to
T14330 22611-22614 DT denotes the
T14332 22615-22617 NN denotes B6
T14331 22618-22622 NNS denotes mice
T14333 22622-22623 . denotes .
T14334 22623-22819 sentence denotes PAI-1 antigen and activity were determined in the CSS with increased rebleeding times, CSS-5, CSS-11, and CSS-17 (Figure 6), the heterosomic, CSS-5F1, CSS-17F1, and double hetersomic, CSS-5 × 17.
T14335 22624-22627 NN denotes PAI
T14337 22627-22628 HYPH denotes -
T14338 22628-22629 CD denotes 1
T14339 22630-22637 NN denotes antigen
T14340 22638-22641 CC denotes and
T14341 22642-22650 NN denotes activity
T14342 22651-22655 VBD denotes were
T14336 22656-22666 VBN denotes determined
T14343 22667-22669 IN denotes in
T14344 22670-22673 DT denotes the
T14345 22674-22677 NNS denotes CSS
T14346 22678-22682 IN denotes with
T14347 22683-22692 VBN denotes increased
T14349 22693-22703 NN denotes rebleeding
T14348 22704-22709 NNS denotes times
T14350 22709-22711 , denotes ,
T14351 22711-22714 NN denotes CSS
T14352 22714-22715 HYPH denotes -
T14353 22715-22716 CD denotes 5
T14354 22716-22718 , denotes ,
T14355 22718-22721 NN denotes CSS
T14356 22721-22722 HYPH denotes -
T14357 22722-22724 CD denotes 11
T14358 22724-22726 , denotes ,
T14359 22726-22729 CC denotes and
T14360 22730-22733 NN denotes CSS
T14361 22733-22734 HYPH denotes -
T14362 22734-22736 CD denotes 17
T14363 22737-22738 -LRB- denotes (
T14364 22738-22744 NN denotes Figure
T14365 22745-22746 CD denotes 6
T14366 22746-22747 -RRB- denotes )
T14367 22747-22749 , denotes ,
T14368 22749-22752 DT denotes the
T14369 22753-22764 JJ denotes heterosomic
T14370 22764-22766 , denotes ,
T14371 22766-22769 NN denotes CSS
T14373 22769-22770 HYPH denotes -
T14372 22770-22773 NN denotes 5F1
T14374 22773-22775 , denotes ,
T14375 22775-22778 NN denotes CSS
T14377 22778-22779 HYPH denotes -
T14376 22779-22783 NN denotes 17F1
T14378 22783-22785 , denotes ,
T14379 22785-22788 CC denotes and
T14380 22789-22795 JJ denotes double
T14381 22796-22806 JJ denotes hetersomic
T14382 22806-22808 , denotes ,
T14383 22808-22811 NN denotes CSS
T14384 22811-22812 HYPH denotes -
T14385 22812-22813 CD denotes 5
T14386 22814-22815 SYM denotes ×
T14387 22816-22818 CD denotes 17
T14388 22818-22819 . denotes .
T14389 22819-22918 sentence denotes CSS-5, CSS-17, CSS-5F1, and CSS-17F1 generally had reduced PAI-1 antigen when compared to B6 mice.
T14390 22820-22823 NN denotes CSS
T14392 22823-22824 HYPH denotes -
T14393 22824-22825 CD denotes 5
T14394 22825-22827 , denotes ,
T14395 22827-22830 NN denotes CSS
T14396 22830-22831 HYPH denotes -
T14397 22831-22833 CD denotes 17
T14398 22833-22835 , denotes ,
T14399 22835-22838 NN denotes CSS
T14401 22838-22839 HYPH denotes -
T14400 22839-22842 NN denotes 5F1
T14402 22842-22844 , denotes ,
T14403 22844-22847 CC denotes and
T14404 22848-22851 NN denotes CSS
T14406 22851-22852 HYPH denotes -
T14405 22852-22856 NN denotes 17F1
T14407 22857-22866 RB denotes generally
T14391 22867-22870 VBD denotes had
T14408 22871-22878 VBN denotes reduced
T14410 22879-22882 NN denotes PAI
T14411 22882-22883 HYPH denotes -
T14412 22883-22884 CD denotes 1
T14409 22885-22892 NN denotes antigen
T14413 22893-22897 WRB denotes when
T14414 22898-22906 VBN denotes compared
T14415 22907-22909 IN denotes to
T14416 22910-22912 NN denotes B6
T14417 22913-22917 NNS denotes mice
T14418 22917-22918 . denotes .
T14419 22918-23061 sentence denotes The reduced PAI-1 antigen was a dominant trait due to the fact that the values were similar in the homosomic and heterosomic CSS-5 and CSS-17.
T14420 22919-22922 DT denotes The
T14422 22923-22930 VBN denotes reduced
T14423 22931-22934 NN denotes PAI
T14424 22934-22935 HYPH denotes -
T14425 22935-22936 CD denotes 1
T14421 22937-22944 NN denotes antigen
T14426 22945-22948 VBD denotes was
T14427 22949-22950 DT denotes a
T14429 22951-22959 JJ denotes dominant
T14428 22960-22965 NN denotes trait
T14430 22966-22969 IN denotes due
T14431 22970-22972 IN denotes to
T14432 22973-22976 DT denotes the
T14433 22977-22981 NN denotes fact
T14434 22982-22986 IN denotes that
T14436 22987-22990 DT denotes the
T14437 22991-22997 NNS denotes values
T14435 22998-23002 VBD denotes were
T14438 23003-23010 JJ denotes similar
T14439 23011-23013 IN denotes in
T14440 23014-23017 DT denotes the
T14442 23018-23027 JJ denotes homosomic
T14443 23028-23031 CC denotes and
T14444 23032-23043 JJ denotes heterosomic
T14441 23044-23047 NN denotes CSS
T14445 23047-23048 HYPH denotes -
T14446 23048-23049 CD denotes 5
T14447 23050-23053 CC denotes and
T14448 23054-23057 NN denotes CSS
T14449 23057-23058 HYPH denotes -
T14450 23058-23060 CD denotes 17
T14451 23060-23061 . denotes .
T14452 23061-23160 sentence denotes The CSS-5 × CSS-17 double heterosomic strains had values similar to the B6 and A/J parent strains.
T14453 23062-23065 DT denotes The
T14455 23066-23069 NN denotes CSS
T14456 23069-23070 HYPH denotes -
T14457 23070-23071 CD denotes 5
T14458 23072-23073 SYM denotes ×
T14459 23074-23077 NN denotes CSS
T14460 23077-23078 HYPH denotes -
T14461 23078-23080 CD denotes 17
T14462 23081-23087 JJ denotes double
T14463 23088-23099 JJ denotes heterosomic
T14454 23100-23107 NNS denotes strains
T14464 23108-23111 VBD denotes had
T14465 23112-23118 NNS denotes values
T14466 23119-23126 JJ denotes similar
T14467 23127-23129 IN denotes to
T14468 23130-23133 DT denotes the
T14470 23134-23136 NN denotes B6
T14471 23137-23140 CC denotes and
T14472 23141-23142 NN denotes A
T14474 23142-23143 HYPH denotes /
T14473 23143-23144 NN denotes J
T14475 23145-23151 NN denotes parent
T14469 23152-23159 NNS denotes strains
T14476 23159-23160 . denotes .
T14477 23160-23361 sentence denotes PAI-1 activity was significantly reduced in the CSS-5 and CSS-17F1 mice, but again in the CSS-5 × CSS-17 strain the value for PAI-1 activity was restored to the value of the B6 and A/J parent strains.
T14478 23161-23164 NN denotes PAI
T14480 23164-23165 HYPH denotes -
T14481 23165-23166 CD denotes 1
T14479 23167-23175 NN denotes activity
T14483 23176-23179 VBD denotes was
T14484 23180-23193 RB denotes significantly
T14482 23194-23201 VBN denotes reduced
T14485 23202-23204 IN denotes in
T14486 23205-23208 DT denotes the
T14488 23209-23212 NN denotes CSS
T14489 23212-23213 HYPH denotes -
T14490 23213-23214 CD denotes 5
T14491 23215-23218 CC denotes and
T14492 23219-23222 NN denotes CSS
T14494 23222-23223 HYPH denotes -
T14493 23223-23227 NN denotes 17F1
T14487 23228-23232 NNS denotes mice
T14495 23232-23234 , denotes ,
T14496 23234-23237 CC denotes but
T14497 23238-23243 RB denotes again
T14499 23244-23246 IN denotes in
T14500 23247-23250 DT denotes the
T14502 23251-23254 NN denotes CSS
T14503 23254-23255 HYPH denotes -
T14504 23255-23256 CD denotes 5
T14505 23257-23258 SYM denotes ×
T14506 23259-23262 NN denotes CSS
T14507 23262-23263 HYPH denotes -
T14508 23263-23265 CD denotes 17
T14501 23266-23272 NN denotes strain
T14509 23273-23276 DT denotes the
T14510 23277-23282 NN denotes value
T14511 23283-23286 IN denotes for
T14512 23287-23290 NN denotes PAI
T14514 23290-23291 HYPH denotes -
T14515 23291-23292 CD denotes 1
T14513 23293-23301 NN denotes activity
T14516 23302-23305 VBD denotes was
T14498 23306-23314 VBN denotes restored
T14517 23315-23317 IN denotes to
T14518 23318-23321 DT denotes the
T14519 23322-23327 NN denotes value
T14520 23328-23330 IN denotes of
T14521 23331-23334 DT denotes the
T14523 23335-23337 NN denotes B6
T14524 23338-23341 CC denotes and
T14525 23342-23343 NN denotes A
T14527 23343-23344 HYPH denotes /
T14526 23344-23345 NN denotes J
T14528 23346-23352 NN denotes parent
T14522 23353-23360 NNS denotes strains
T14529 23360-23361 . denotes .
T14530 23361-23495 sentence denotes The PAI-1 antigen (5.4 ng/mL ± 0.5, n = 7) and activity (170 U/mL ± 20, n = 6) in the CSS-11 mice was not different than for B6 mice.
T14531 23362-23365 DT denotes The
T14533 23366-23369 NN denotes PAI
T14534 23369-23370 HYPH denotes -
T14535 23370-23371 CD denotes 1
T14532 23372-23379 NN denotes antigen
T14537 23380-23381 -LRB- denotes (
T14539 23381-23384 CD denotes 5.4
T14538 23385-23387 NNS denotes ng
T14540 23387-23388 SYM denotes /
T14541 23388-23390 NN denotes mL
T14542 23391-23392 SYM denotes ±
T14543 23393-23396 CD denotes 0.5
T14544 23396-23398 , denotes ,
T14545 23398-23399 NN denotes n
T14547 23400-23401 SYM denotes =
T14546 23402-23403 CD denotes 7
T14548 23403-23404 -RRB- denotes )
T14549 23405-23408 CC denotes and
T14550 23409-23417 NN denotes activity
T14551 23418-23419 -LRB- denotes (
T14553 23419-23422 CD denotes 170
T14552 23423-23424 NNS denotes U
T14554 23424-23425 SYM denotes /
T14555 23425-23427 NN denotes mL
T14556 23428-23429 SYM denotes ±
T14557 23430-23432 CD denotes 20
T14558 23432-23434 , denotes ,
T14559 23434-23435 NN denotes n
T14561 23436-23437 SYM denotes =
T14560 23438-23439 CD denotes 6
T14562 23439-23440 -RRB- denotes )
T14563 23441-23443 IN denotes in
T14564 23444-23447 DT denotes the
T14566 23448-23451 NN denotes CSS
T14567 23451-23452 HYPH denotes -
T14568 23452-23454 CD denotes 11
T14565 23455-23459 NNS denotes mice
T14536 23460-23463 VBD denotes was
T14569 23464-23467 RB denotes not
T14570 23468-23477 JJ denotes different
T14571 23478-23482 IN denotes than
T14572 23483-23486 IN denotes for
T14573 23487-23489 NN denotes B6
T14574 23490-23494 NNS denotes mice
T14575 23494-23495 . denotes .
T22647 23506-23509 NN denotes PAI
T22648 23509-23510 HYPH denotes -
T22649 23510-23511 CD denotes 1
T22650 23512-23514 IN denotes in
T22651 23515-23518 DT denotes the
T22653 23519-23522 NN denotes CSS
T22652 23523-23534 NNS denotes backcrosses
T22654 23534-23535 . denotes .
T22655 23535-23755 sentence denotes Panel A: Plasma PAI-1 antigen (ng/mL) and Panel B: Plasma PAI-1 activity (U/mL) were tested in heterosomic mice, (B6xCSS-5)F1 (5F1) and (B6xCSS-17)F1 (17F1) and doubly heterosomic mice for chromosomes 5 and 17 (5 × 17).
T22656 23536-23541 NN denotes Panel
T22657 23542-23543 NN denotes A
T22659 23543-23545 : denotes :
T22660 23545-23551 NN denotes Plasma
T22662 23552-23555 NN denotes PAI
T22663 23555-23556 HYPH denotes -
T22664 23556-23557 CD denotes 1
T22661 23558-23565 NN denotes antigen
T22665 23566-23567 -LRB- denotes (
T22666 23567-23569 NNS denotes ng
T22667 23569-23570 SYM denotes /
T22668 23570-23572 NN denotes mL
T22669 23572-23573 -RRB- denotes )
T22670 23574-23577 CC denotes and
T22671 23578-23583 NN denotes Panel
T22672 23584-23585 NN denotes B
T22673 23585-23587 : denotes :
T22674 23587-23593 NN denotes Plasma
T22676 23594-23597 NN denotes PAI
T22677 23597-23598 HYPH denotes -
T22678 23598-23599 CD denotes 1
T22675 23600-23608 NN denotes activity
T22679 23609-23610 -LRB- denotes (
T22680 23610-23611 NNS denotes U
T22681 23611-23612 SYM denotes /
T22682 23612-23614 NN denotes mL
T22683 23614-23615 -RRB- denotes )
T22684 23616-23620 VBD denotes were
T22658 23621-23627 VBN denotes tested
T22685 23628-23630 IN denotes in
T22686 23631-23642 JJ denotes heterosomic
T22687 23643-23647 NNS denotes mice
T22688 23647-23649 , denotes ,
T22689 23649-23650 -LRB- denotes (
T22691 23650-23656 NN denotes B6xCSS
T22692 23656-23657 HYPH denotes -
T22693 23657-23658 CD denotes 5
T22694 23658-23659 -RRB- denotes )
T22690 23659-23661 NN denotes F1
T22695 23662-23663 -LRB- denotes (
T22696 23663-23666 NN denotes 5F1
T22697 23666-23667 -RRB- denotes )
T22698 23668-23671 CC denotes and
T22699 23672-23673 -LRB- denotes (
T22701 23673-23679 NN denotes B6xCSS
T22702 23679-23680 HYPH denotes -
T22703 23680-23682 CD denotes 17
T22704 23682-23683 -RRB- denotes )
T22700 23683-23685 NN denotes F1
T22705 23686-23687 -LRB- denotes (
T22706 23687-23691 NN denotes 17F1
T22707 23691-23692 -RRB- denotes )
T22708 23693-23696 CC denotes and
T22709 23697-23703 RB denotes doubly
T22710 23704-23715 JJ denotes heterosomic
T22711 23716-23720 NNS denotes mice
T22712 23721-23724 IN denotes for
T22713 23725-23736 NNS denotes chromosomes
T22714 23737-23738 CD denotes 5
T22715 23739-23742 CC denotes and
T22716 23743-23745 CD denotes 17
T22717 23746-23747 -LRB- denotes (
T22718 23747-23748 CD denotes 5
T22720 23749-23750 SYM denotes ×
T22719 23751-23753 CD denotes 17
T22721 23753-23754 -RRB- denotes )
T22722 23754-23755 . denotes .
T22723 23755-23793 sentence denotes Bars are the mean ± SEM of 5–18 mice.
T22724 23756-23760 NNS denotes Bars
T22725 23761-23764 VBP denotes are
T22726 23765-23768 DT denotes the
T22728 23769-23773 NN denotes mean
T22729 23774-23775 SYM denotes ±
T22727 23776-23779 NN denotes SEM
T22730 23780-23782 IN denotes of
T22731 23783-23784 CD denotes 5
T22733 23784-23785 SYM denotes –
T22732 23785-23787 CD denotes 18
T22734 23788-23792 NNS denotes mice
T22735 23792-23793 . denotes .
T22736 23793-23953 sentence denotes Statistical differences between B6 mice and CSS were determined with a t-test, and a Bonferroni correction was made to determine significance value (P < 0.01).
T22737 23794-23805 JJ denotes Statistical
T22738 23806-23817 NNS denotes differences
T22740 23818-23825 IN denotes between
T22741 23826-23828 NN denotes B6
T22742 23829-23833 NNS denotes mice
T22743 23834-23837 CC denotes and
T22744 23838-23841 NN denotes CSS
T22745 23842-23846 VBD denotes were
T22739 23847-23857 VBN denotes determined
T22746 23858-23862 IN denotes with
T22747 23863-23864 DT denotes a
T22749 23865-23866 NN denotes t
T22750 23866-23867 HYPH denotes -
T22748 23867-23871 NN denotes test
T22751 23871-23873 , denotes ,
T22752 23873-23876 CC denotes and
T22753 23877-23878 DT denotes a
T22755 23879-23889 NNP denotes Bonferroni
T22754 23890-23900 NN denotes correction
T22757 23901-23904 VBD denotes was
T22756 23905-23909 VBN denotes made
T22758 23910-23912 TO denotes to
T22759 23913-23922 VB denotes determine
T22760 23923-23935 NN denotes significance
T22761 23936-23941 NN denotes value
T22762 23942-23943 -LRB- denotes (
T22764 23943-23944 NN denotes P
T22765 23945-23946 SYM denotes <
T22763 23947-23951 CD denotes 0.01
T22766 23951-23952 -RRB- denotes )
T22767 23952-23953 . denotes .
T22768 23953-24014 sentence denotes Symbols indicate a significant difference between B6 values.
T22769 23954-23961 NNS denotes Symbols
T22770 23962-23970 VBP denotes indicate
T22771 23971-23972 DT denotes a
T22773 23973-23984 JJ denotes significant
T22772 23985-23995 NN denotes difference
T22774 23996-24003 IN denotes between
T22775 24004-24006 NN denotes B6
T22776 24007-24013 NNS denotes values
T22777 24013-24014 . denotes .
T22778 24014-24025 sentence denotes *P < 0.01.
T22779 24015-24016 SYM denotes *
T22780 24016-24017 NN denotes P
T22782 24018-24019 SYM denotes <
T22781 24020-24024 CD denotes 0.01
T22783 24024-24025 . denotes .
T14903 24027-24039 NNS denotes Interactions
T14904 24040-24042 IN denotes of
T14905 24043-24046 NN denotes CSS
T14906 24047-24050 IN denotes for
T14907 24051-24059 JJ denotes arterial
T14908 24060-24068 NN denotes thrombus
T14909 24069-24078 NN denotes formation
T14910 24078-24275 sentence denotes The tail bleeding assay was rapid and facilitated the screening of the 21 CSS strains, and subsequently the identified strains were tested for arterial occlusion after the FeCl3 injury (Figure 7).
T14911 24079-24082 DT denotes The
T14913 24083-24087 NN denotes tail
T14914 24088-24096 NN denotes bleeding
T14912 24097-24102 NN denotes assay
T14915 24103-24106 VBD denotes was
T14916 24107-24112 JJ denotes rapid
T14917 24113-24116 CC denotes and
T14918 24117-24128 VBD denotes facilitated
T14919 24129-24132 DT denotes the
T14920 24133-24142 NN denotes screening
T14921 24143-24145 IN denotes of
T14922 24146-24149 DT denotes the
T14924 24150-24152 CD denotes 21
T14925 24153-24156 NN denotes CSS
T14923 24157-24164 NNS denotes strains
T14926 24164-24166 , denotes ,
T14927 24166-24169 CC denotes and
T14928 24170-24182 RB denotes subsequently
T14930 24183-24186 DT denotes the
T14932 24187-24197 VBN denotes identified
T14931 24198-24205 NNS denotes strains
T14933 24206-24210 VBD denotes were
T14929 24211-24217 VBN denotes tested
T14934 24218-24221 IN denotes for
T14935 24222-24230 JJ denotes arterial
T14936 24231-24240 NN denotes occlusion
T14937 24241-24246 IN denotes after
T14938 24247-24250 DT denotes the
T14940 24251-24256 NN denotes FeCl3
T14939 24257-24263 NN denotes injury
T14941 24264-24265 -LRB- denotes (
T14942 24265-24271 NN denotes Figure
T14943 24272-24273 CD denotes 7
T14944 24273-24274 -RRB- denotes )
T14945 24274-24275 . denotes .
T14946 24275-24501 sentence denotes The CSS-5 and CSS-17 had occlusion times similar to the B6 mice, but the doubly heterosomic CSS-5 × CSS-17 progeny had occlusion times higher than either the B6 mice or the heterosomic CSS-5F1 and CSS-17F1 or the A/J strains.
T14947 24276-24279 DT denotes The
T14948 24280-24283 NN denotes CSS
T14950 24283-24284 HYPH denotes -
T14951 24284-24285 CD denotes 5
T14952 24286-24289 CC denotes and
T14953 24290-24293 NN denotes CSS
T14954 24293-24294 HYPH denotes -
T14955 24294-24296 CD denotes 17
T14949 24297-24300 VBD denotes had
T14956 24301-24310 NN denotes occlusion
T14957 24311-24316 NNS denotes times
T14958 24317-24324 JJ denotes similar
T14959 24325-24327 IN denotes to
T14960 24328-24331 DT denotes the
T14962 24332-24334 NN denotes B6
T14961 24335-24339 NNS denotes mice
T14963 24339-24341 , denotes ,
T14964 24341-24344 CC denotes but
T14965 24345-24348 DT denotes the
T14967 24349-24355 RB denotes doubly
T14968 24356-24367 JJ denotes heterosomic
T14969 24368-24371 NN denotes CSS
T14970 24371-24372 HYPH denotes -
T14971 24372-24373 CD denotes 5
T14972 24374-24375 SYM denotes ×
T14973 24376-24379 NN denotes CSS
T14974 24379-24380 HYPH denotes -
T14975 24380-24382 CD denotes 17
T14966 24383-24390 NN denotes progeny
T14976 24391-24394 VBD denotes had
T14977 24395-24404 NN denotes occlusion
T14978 24405-24410 NNS denotes times
T14979 24411-24417 JJR denotes higher
T14980 24418-24422 IN denotes than
T14981 24423-24429 CC denotes either
T14983 24430-24433 DT denotes the
T14984 24434-24436 NN denotes B6
T14982 24437-24441 NNS denotes mice
T14985 24442-24444 CC denotes or
T14986 24445-24448 DT denotes the
T14988 24449-24460 JJ denotes heterosomic
T14989 24461-24464 NN denotes CSS
T14990 24464-24465 HYPH denotes -
T14987 24465-24468 NN denotes 5F1
T14991 24469-24472 CC denotes and
T14992 24473-24476 NN denotes CSS
T14994 24476-24477 HYPH denotes -
T14993 24477-24481 NN denotes 17F1
T14995 24482-24484 CC denotes or
T14996 24485-24488 DT denotes the
T14998 24489-24490 NN denotes A
T14999 24490-24491 HYPH denotes /
T14997 24491-24492 NN denotes J
T15000 24493-24500 NNS denotes strains
T15001 24500-24501 . denotes .
T15002 24501-24644 sentence denotes In double heterosomic CSS-5 × CSS-17 mice, only one or three mice tested had occluded by 30 min; the other two mice did not occlude by 30 min.
T15003 24502-24504 IN denotes In
T15005 24505-24511 JJ denotes double
T15006 24512-24523 JJ denotes heterosomic
T15008 24524-24527 NN denotes CSS
T15009 24527-24528 HYPH denotes -
T15010 24528-24529 CD denotes 5
T15011 24530-24531 SYM denotes ×
T15012 24532-24535 NN denotes CSS
T15013 24535-24536 HYPH denotes -
T15014 24536-24538 CD denotes 17
T15007 24539-24543 NNS denotes mice
T15015 24543-24545 , denotes ,
T15016 24545-24549 RB denotes only
T15018 24550-24553 CD denotes one
T15019 24554-24556 CC denotes or
T15020 24557-24562 CD denotes three
T15017 24563-24567 NNS denotes mice
T15021 24568-24574 VBN denotes tested
T15022 24575-24578 VBD denotes had
T15004 24579-24587 VBN denotes occluded
T15024 24588-24590 IN denotes by
T15025 24591-24593 CD denotes 30
T15026 24594-24597 NNS denotes min
T15027 24597-24598 : denotes ;
T15028 24599-24602 DT denotes the
T15030 24603-24608 JJ denotes other
T15031 24609-24612 CD denotes two
T15029 24613-24617 NNS denotes mice
T15032 24618-24621 VBD denotes did
T15033 24622-24625 RB denotes not
T15023 24626-24633 VB denotes occlude
T15034 24634-24636 IN denotes by
T15035 24637-24639 CD denotes 30
T15036 24640-24643 NNS denotes min
T15037 24643-24644 . denotes .
T15038 24644-24841 sentence denotes While only a small number of CSS mice have been tested for the arterial occlusion, the results suggest that interaction of the genes on chromosome 5 and 17 also determines arterial occlusion time.
T15039 24645-24650 IN denotes While
T15041 24651-24655 RB denotes only
T15043 24656-24657 DT denotes a
T15044 24658-24663 JJ denotes small
T15042 24664-24670 NN denotes number
T15045 24671-24673 IN denotes of
T15046 24674-24677 NN denotes CSS
T15047 24678-24682 NNS denotes mice
T15048 24683-24687 VBP denotes have
T15049 24688-24692 VBN denotes been
T15040 24693-24699 VBN denotes tested
T15051 24700-24703 IN denotes for
T15052 24704-24707 DT denotes the
T15054 24708-24716 JJ denotes arterial
T15053 24717-24726 NN denotes occlusion
T15055 24726-24728 , denotes ,
T15056 24728-24731 DT denotes the
T15057 24732-24739 NNS denotes results
T15050 24740-24747 VBP denotes suggest
T15058 24748-24752 IN denotes that
T15060 24753-24764 NN denotes interaction
T15061 24765-24767 IN denotes of
T15062 24768-24771 DT denotes the
T15063 24772-24777 NNS denotes genes
T15064 24778-24780 IN denotes on
T15065 24781-24791 NN denotes chromosome
T15066 24792-24793 CD denotes 5
T15067 24794-24797 CC denotes and
T15068 24798-24800 CD denotes 17
T15069 24801-24805 RB denotes also
T15059 24806-24816 VBZ denotes determines
T15070 24817-24825 JJ denotes arterial
T15071 24826-24835 NN denotes occlusion
T15072 24836-24840 NN denotes time
T15073 24840-24841 . denotes .
T22995 24852-24860 JJ denotes Arterial
T22996 24861-24870 NN denotes occlusion
T22997 24871-24875 NN denotes time
T22998 24876-24878 IN denotes in
T22999 24879-24882 DT denotes the
T23001 24883-24886 NN denotes CSS
T23000 24887-24898 NNS denotes backcrosses
T23002 24898-24899 . denotes .
T23003 24899-25058 sentence denotes Occlusion time was determined in heterosomic mice, (B6xCSS-5)F1 (5F1) and (B6xCSS-17)F1 (17F1), and doubly heterosomic mice for chromosomes 5 and 17 (5 × 17).
T23004 24900-24909 NN denotes Occlusion
T23005 24910-24914 NN denotes time
T23007 24915-24918 VBD denotes was
T23006 24919-24929 VBN denotes determined
T23008 24930-24932 IN denotes in
T23009 24933-24944 JJ denotes heterosomic
T23010 24945-24949 NNS denotes mice
T23011 24949-24951 , denotes ,
T23012 24951-24952 -LRB- denotes (
T23013 24952-24958 NN denotes B6xCSS
T23015 24958-24959 HYPH denotes -
T23016 24959-24960 CD denotes 5
T23017 24960-24961 -RRB- denotes )
T23014 24961-24963 NN denotes F1
T23018 24964-24965 -LRB- denotes (
T23019 24965-24968 NN denotes 5F1
T23020 24968-24969 -RRB- denotes )
T23021 24970-24973 CC denotes and
T23022 24974-24975 -LRB- denotes (
T23024 24975-24981 NN denotes B6xCSS
T23025 24981-24982 HYPH denotes -
T23026 24982-24984 CD denotes 17
T23027 24984-24985 -RRB- denotes )
T23023 24985-24987 NN denotes F1
T23028 24988-24989 -LRB- denotes (
T23029 24989-24993 NN denotes 17F1
T23030 24993-24994 -RRB- denotes )
T23031 24994-24996 , denotes ,
T23032 24996-24999 CC denotes and
T23033 25000-25006 RB denotes doubly
T23034 25007-25018 JJ denotes heterosomic
T23035 25019-25023 NNS denotes mice
T23036 25024-25027 IN denotes for
T23037 25028-25039 NNS denotes chromosomes
T23038 25040-25041 CD denotes 5
T23039 25042-25045 CC denotes and
T23040 25046-25048 CD denotes 17
T23041 25049-25050 -LRB- denotes (
T23042 25050-25051 CD denotes 5
T23044 25052-25053 SYM denotes ×
T23043 25054-25056 CD denotes 17
T23045 25056-25057 -RRB- denotes )
T23046 25057-25058 . denotes .
T23047 25058-25096 sentence denotes Bars are the mean ± SEM of 5–18 mice.
T23048 25059-25063 NNS denotes Bars
T23049 25064-25067 VBP denotes are
T23050 25068-25071 DT denotes the
T23052 25072-25076 NN denotes mean
T23053 25077-25078 SYM denotes ±
T23051 25079-25082 NN denotes SEM
T23054 25083-25085 IN denotes of
T23055 25086-25087 CD denotes 5
T23057 25087-25088 SYM denotes –
T23056 25088-25090 CD denotes 18
T23058 25091-25095 NNS denotes mice
T23059 25095-25096 . denotes .
T23060 25096-25256 sentence denotes Statistical differences between B6 mice and CSS were determined with a t-test, and a Bonferroni correction was made to determine significance value (P < 0.02).
T23061 25097-25108 JJ denotes Statistical
T23062 25109-25120 NNS denotes differences
T23064 25121-25128 IN denotes between
T23065 25129-25131 NN denotes B6
T23066 25132-25136 NNS denotes mice
T23067 25137-25140 CC denotes and
T23068 25141-25144 NN denotes CSS
T23069 25145-25149 VBD denotes were
T23063 25150-25160 VBN denotes determined
T23070 25161-25165 IN denotes with
T23071 25166-25167 DT denotes a
T23073 25168-25169 NN denotes t
T23074 25169-25170 HYPH denotes -
T23072 25170-25174 NN denotes test
T23075 25174-25176 , denotes ,
T23076 25176-25179 CC denotes and
T23077 25180-25181 DT denotes a
T23079 25182-25192 NNP denotes Bonferroni
T23078 25193-25203 NN denotes correction
T23081 25204-25207 VBD denotes was
T23080 25208-25212 VBN denotes made
T23082 25213-25215 TO denotes to
T23083 25216-25225 VB denotes determine
T23084 25226-25238 NN denotes significance
T23085 25239-25244 NN denotes value
T23086 25245-25246 -LRB- denotes (
T23088 25246-25247 NN denotes P
T23089 25248-25249 SYM denotes <
T23087 25250-25254 CD denotes 0.02
T23090 25254-25255 -RRB- denotes )
T23091 25255-25256 . denotes .
T23092 25256-25317 sentence denotes Symbols indicate a significant difference between B6 values.
T23093 25257-25264 NNS denotes Symbols
T23094 25265-25273 VBP denotes indicate
T23095 25274-25275 DT denotes a
T23097 25276-25287 JJ denotes significant
T23096 25288-25298 NN denotes difference
T23098 25299-25306 IN denotes between
T23099 25307-25309 NN denotes B6
T23100 25310-25316 NNS denotes values
T23101 25316-25317 . denotes .
T23102 25317-25330 sentence denotes *P < 0.0001.
T23103 25318-25319 SYM denotes *
T23104 25319-25320 NN denotes P
T23106 25321-25322 SYM denotes <
T23105 25323-25329 CD denotes 0.0001
T23107 25329-25330 . denotes .
T18534 25343-25345 IN denotes In
T18536 25346-25350 DT denotes this
T18537 25351-25356 NN denotes study
T18538 25356-25358 , denotes ,
T18539 25358-25368 JJ denotes thrombotic
T18540 25369-25373 NN denotes risk
T18541 25374-25377 VBD denotes was
T18542 25378-25392 RB denotes systematically
T18535 25393-25401 VBN denotes assessed
T18543 25402-25404 IN denotes in
T18544 25405-25408 CD denotes two
T18546 25409-25415 JJ denotes inbred
T18545 25416-25423 NNS denotes strains
T18547 25424-25426 IN denotes of
T18548 25427-25431 NNS denotes mice
T18549 25432-25436 WDT denotes that
T18550 25437-25441 VBP denotes have
T18551 25442-25448 VBN denotes marked
T18552 25449-25460 NNS denotes differences
T18553 25461-25463 IN denotes in
T18554 25464-25478 NN denotes susceptibility
T18555 25479-25481 IN denotes to
T18556 25482-25486 NN denotes diet
T18558 25486-25487 HYPH denotes -
T18557 25487-25494 VBN denotes induced
T18559 25495-25502 NN denotes obesity
T18560 25502-25504 , denotes ,
T18561 25504-25508 NN denotes diet
T18563 25508-25509 HYPH denotes -
T18562 25509-25516 VBN denotes induced
T18564 25517-25532 NN denotes atherosclerosis
T18565 25532-25534 , denotes ,
T18566 25534-25537 CC denotes and
T18567 25538-25546 NN denotes ligation
T18569 25546-25547 HYPH denotes -
T18568 25547-25554 VBN denotes induced
T18571 25555-25565 JJ denotes neointimal
T18570 25566-25577 NN denotes hyperplasia
T18572 25578-25581 CC denotes and
T18573 25582-25588 NN denotes vessel
T18574 25589-25599 NN denotes remodeling
T18575 25599-25600 . denotes .
T18576 25600-25722 sentence denotes Arterial occlusion time, tail bleeding and rebleeding time were evaluated as potential predictors of thrombotic response.
T18577 25601-25609 JJ denotes Arterial
T18578 25610-25619 NN denotes occlusion
T18579 25620-25624 NN denotes time
T18581 25624-25626 , denotes ,
T18582 25626-25630 NN denotes tail
T18583 25631-25639 NN denotes bleeding
T18585 25640-25643 CC denotes and
T18586 25644-25654 NN denotes rebleeding
T18584 25655-25659 NN denotes time
T18587 25660-25664 VBD denotes were
T18580 25665-25674 VBN denotes evaluated
T18588 25675-25677 IN denotes as
T18589 25678-25687 JJ denotes potential
T18590 25688-25698 NNS denotes predictors
T18591 25699-25701 IN denotes of
T18592 25702-25712 JJ denotes thrombotic
T18593 25713-25721 NN denotes response
T18594 25721-25722 . denotes .
T18595 25722-25934 sentence denotes Assessments of the two inbred strains were compared to values from gene targeted mice of the Plg network with altered fibrinolytic responses, as well as in leptin deficient mice with a reduced platelet function.
T18596 25723-25734 NNS denotes Assessments
T18598 25735-25737 IN denotes of
T18599 25738-25741 DT denotes the
T18601 25742-25745 CD denotes two
T18602 25746-25752 JJ denotes inbred
T18600 25753-25760 NNS denotes strains
T18603 25761-25765 VBD denotes were
T18597 25766-25774 VBN denotes compared
T18604 25775-25777 IN denotes to
T18605 25778-25784 NNS denotes values
T18606 25785-25789 IN denotes from
T18607 25790-25794 NN denotes gene
T18608 25795-25803 VBN denotes targeted
T18609 25804-25808 NNS denotes mice
T18610 25809-25811 IN denotes of
T18611 25812-25815 DT denotes the
T18613 25816-25819 NN denotes Plg
T18612 25820-25827 NN denotes network
T18614 25828-25832 IN denotes with
T18615 25833-25840 VBN denotes altered
T18617 25841-25853 JJ denotes fibrinolytic
T18616 25854-25863 NNS denotes responses
T18618 25863-25865 , denotes ,
T18619 25865-25867 RB denotes as
T18621 25868-25872 RB denotes well
T18620 25873-25875 IN denotes as
T18622 25876-25878 IN denotes in
T18623 25879-25885 NN denotes leptin
T18624 25886-25895 JJ denotes deficient
T18625 25896-25900 NNS denotes mice
T18626 25901-25905 IN denotes with
T18627 25906-25907 DT denotes a
T18629 25908-25915 VBN denotes reduced
T18630 25916-25924 NN denotes platelet
T18628 25925-25933 NN denotes function
T18631 25933-25934 . denotes .
T18632 25934-26131 sentence denotes Marked differences were found in the thrombotic response among the two inbred strains, B6 and A/J, and the observed differences were not correlated with change in coagulation or platelet function.
T18633 25935-25941 JJ denotes Marked
T18634 25942-25953 NNS denotes differences
T18636 25954-25958 VBD denotes were
T18635 25959-25964 VBN denotes found
T18637 25965-25967 IN denotes in
T18638 25968-25971 DT denotes the
T18640 25972-25982 JJ denotes thrombotic
T18639 25983-25991 NN denotes response
T18641 25992-25997 IN denotes among
T18642 25998-26001 DT denotes the
T18644 26002-26005 CD denotes two
T18645 26006-26012 JJ denotes inbred
T18643 26013-26020 NNS denotes strains
T18646 26020-26022 , denotes ,
T18647 26022-26024 NN denotes B6
T18648 26025-26028 CC denotes and
T18649 26029-26030 NN denotes A
T18651 26030-26031 HYPH denotes /
T18650 26031-26032 NN denotes J
T18652 26032-26034 , denotes ,
T18653 26034-26037 CC denotes and
T18654 26038-26041 DT denotes the
T18656 26042-26050 VBN denotes observed
T18655 26051-26062 NNS denotes differences
T18658 26063-26067 VBD denotes were
T18659 26068-26071 RB denotes not
T18657 26072-26082 VBN denotes correlated
T18660 26083-26087 IN denotes with
T18661 26088-26094 NN denotes change
T18662 26095-26097 IN denotes in
T18663 26098-26109 NN denotes coagulation
T18664 26110-26112 CC denotes or
T18665 26113-26121 NN denotes platelet
T18666 26122-26130 NN denotes function
T18667 26130-26131 . denotes .
T18668 26131-26267 sentence denotes Screening the CSS identified three chromosomes that harbored genes which contributed to the A/J phenotype of increased rebleeding time.
T18669 26132-26141 VBG denotes Screening
T18671 26142-26145 DT denotes the
T18672 26146-26149 NN denotes CSS
T18670 26150-26160 VBD denotes identified
T18673 26161-26166 CD denotes three
T18674 26167-26178 NNS denotes chromosomes
T18675 26179-26183 WDT denotes that
T18676 26184-26192 VBD denotes harbored
T18677 26193-26198 NNS denotes genes
T18678 26199-26204 WDT denotes which
T18679 26205-26216 VBD denotes contributed
T18680 26217-26219 IN denotes to
T18681 26220-26223 DT denotes the
T18683 26224-26225 NN denotes A
T18685 26225-26226 HYPH denotes /
T18684 26226-26227 NN denotes J
T18682 26228-26237 NN denotes phenotype
T18686 26238-26240 IN denotes of
T18687 26241-26250 VBN denotes increased
T18689 26251-26261 NN denotes rebleeding
T18688 26262-26266 NN denotes time
T18690 26266-26267 . denotes .
T18691 26267-26434 sentence denotes Mice homosomic for these chromosomes or doubly heterosomic for two of the chromosomes, 5 and 17, were required to express the A/J phenotype, elevated rebleeding time.
T18692 26268-26272 NNS denotes Mice
T18694 26273-26282 JJ denotes homosomic
T18695 26283-26286 IN denotes for
T18696 26287-26292 DT denotes these
T18697 26293-26304 NNS denotes chromosomes
T18698 26305-26307 CC denotes or
T18699 26308-26314 RB denotes doubly
T18700 26315-26326 JJ denotes heterosomic
T18701 26327-26330 IN denotes for
T18702 26331-26334 CD denotes two
T18703 26335-26337 IN denotes of
T18704 26338-26341 DT denotes the
T18705 26342-26353 NNS denotes chromosomes
T18706 26353-26355 , denotes ,
T18707 26355-26356 CD denotes 5
T18708 26357-26360 CC denotes and
T18709 26361-26363 CD denotes 17
T18710 26363-26365 , denotes ,
T18711 26365-26369 VBD denotes were
T18693 26370-26378 VBN denotes required
T18712 26379-26381 TO denotes to
T18713 26382-26389 VB denotes express
T18714 26390-26393 DT denotes the
T18716 26394-26395 NN denotes A
T18718 26395-26396 HYPH denotes /
T18717 26396-26397 NN denotes J
T18715 26398-26407 NN denotes phenotype
T18719 26407-26409 , denotes ,
T18720 26409-26417 VBN denotes elevated
T18722 26418-26428 NN denotes rebleeding
T18721 26429-26433 NN denotes time
T18723 26433-26434 . denotes .
T18724 26434-26579 sentence denotes PAI-1 antigen and activity were decreased in both CSS-5 and CSS-17 and the heterosomic mice, CSS-5F1 and CSS-17F1, but not in the CSS-11 strain.
T18725 26435-26438 NN denotes PAI
T18727 26438-26439 HYPH denotes -
T18728 26439-26440 CD denotes 1
T18729 26441-26448 NN denotes antigen
T18730 26449-26452 CC denotes and
T18731 26453-26461 NN denotes activity
T18732 26462-26466 VBD denotes were
T18726 26467-26476 VBN denotes decreased
T18733 26477-26479 IN denotes in
T18734 26480-26484 CC denotes both
T18735 26485-26488 NN denotes CSS
T18736 26488-26489 HYPH denotes -
T18737 26489-26490 CD denotes 5
T18738 26491-26494 CC denotes and
T18739 26495-26498 NN denotes CSS
T18740 26498-26499 HYPH denotes -
T18741 26499-26501 CD denotes 17
T18742 26502-26505 CC denotes and
T18743 26506-26509 DT denotes the
T18745 26510-26521 JJ denotes heterosomic
T18744 26522-26526 NNS denotes mice
T18746 26526-26528 , denotes ,
T18747 26528-26531 NN denotes CSS
T18749 26531-26532 HYPH denotes -
T18748 26532-26535 NN denotes 5F1
T18750 26536-26539 CC denotes and
T18751 26540-26543 NN denotes CSS
T18753 26543-26544 HYPH denotes -
T18752 26544-26548 NN denotes 17F1
T18754 26548-26550 , denotes ,
T18755 26550-26553 CC denotes but
T18756 26554-26557 RB denotes not
T18757 26558-26560 IN denotes in
T18758 26561-26564 DT denotes the
T18760 26565-26568 NN denotes CSS
T18761 26568-26569 HYPH denotes -
T18762 26569-26571 CD denotes 11
T18759 26572-26578 NN denotes strain
T18763 26578-26579 . denotes .
T18764 26579-26660 sentence denotes Values were restored in the doubly heterosomic for two of chromosomes, 5 and 17.
T18765 26580-26586 NNS denotes Values
T18767 26587-26591 VBD denotes were
T18766 26592-26600 VBN denotes restored
T18768 26601-26603 IN denotes in
T18769 26604-26607 DT denotes the
T18771 26608-26614 RB denotes doubly
T18770 26615-26626 JJ denotes heterosomic
T18772 26627-26630 IN denotes for
T18773 26631-26634 CD denotes two
T18774 26635-26637 IN denotes of
T18775 26638-26649 NNS denotes chromosomes
T18776 26649-26651 , denotes ,
T18777 26651-26652 CD denotes 5
T18778 26653-26656 CC denotes and
T18779 26657-26659 CD denotes 17
T18780 26659-26660 . denotes .
T18781 26660-26816 sentence denotes Arterial occlusion time was similar to B6 in the CSS-5 and CSS-17 homozygous strains, but increased in doubly heterosomic for two of chromosomes, 5 and 17.
T18782 26661-26669 JJ denotes Arterial
T18783 26670-26679 NN denotes occlusion
T18784 26680-26684 NN denotes time
T18785 26685-26688 VBD denotes was
T18786 26689-26696 JJ denotes similar
T18787 26697-26699 IN denotes to
T18788 26700-26702 NN denotes B6
T18789 26703-26705 IN denotes in
T18790 26706-26709 DT denotes the
T18792 26710-26713 NN denotes CSS
T18793 26713-26714 HYPH denotes -
T18794 26714-26715 CD denotes 5
T18795 26716-26719 CC denotes and
T18796 26720-26723 NN denotes CSS
T18797 26723-26724 HYPH denotes -
T18798 26724-26726 CD denotes 17
T18799 26727-26737 JJ denotes homozygous
T18791 26738-26745 NNS denotes strains
T18800 26745-26747 , denotes ,
T18801 26747-26750 CC denotes but
T18802 26751-26760 VBD denotes increased
T18803 26761-26763 IN denotes in
T18804 26764-26770 RB denotes doubly
T18805 26771-26782 JJ denotes heterosomic
T18806 26783-26786 IN denotes for
T18807 26787-26790 CD denotes two
T18808 26791-26793 IN denotes of
T18809 26794-26805 NNS denotes chromosomes
T18810 26805-26807 , denotes ,
T18811 26807-26808 CD denotes 5
T18812 26809-26812 CC denotes and
T18813 26813-26815 CD denotes 17
T18814 26815-26816 . denotes .
T18815 26816-26961 sentence denotes The FeCl3-induced model of vascular injury and thrombosis in mice is now widely used to evaluate genetic and pharmacological interventions [24].
T18816 26817-26820 DT denotes The
T18818 26821-26826 NN denotes FeCl3
T18820 26826-26827 HYPH denotes -
T18819 26827-26834 VBN denotes induced
T18817 26835-26840 NN denotes model
T18822 26841-26843 IN denotes of
T18823 26844-26852 JJ denotes vascular
T18824 26853-26859 NN denotes injury
T18825 26860-26863 CC denotes and
T18826 26864-26874 NN denotes thrombosis
T18827 26875-26877 IN denotes in
T18828 26878-26882 NNS denotes mice
T18829 26883-26885 VBZ denotes is
T18830 26886-26889 RB denotes now
T18831 26890-26896 RB denotes widely
T18821 26897-26901 VBN denotes used
T18832 26902-26904 TO denotes to
T18833 26905-26913 VB denotes evaluate
T18834 26914-26921 JJ denotes genetic
T18836 26922-26925 CC denotes and
T18837 26926-26941 JJ denotes pharmacological
T18835 26942-26955 NNS denotes interventions
T18838 26956-26957 -LRB- denotes [
T18839 26957-26959 CD denotes 24
T18840 26959-26960 -RRB- denotes ]
T18841 26960-26961 . denotes .
T18842 26961-27075 sentence denotes The two inbred strains had marked differences in the time for occlusion of the carotid artery after FeCl3 injury.
T18843 26962-26965 DT denotes The
T18845 26966-26969 CD denotes two
T18846 26970-26976 JJ denotes inbred
T18844 26977-26984 NNS denotes strains
T18847 26985-26988 VBD denotes had
T18848 26989-26995 JJ denotes marked
T18849 26996-27007 NNS denotes differences
T18850 27008-27010 IN denotes in
T18851 27011-27014 DT denotes the
T18852 27015-27019 NN denotes time
T18853 27020-27023 IN denotes for
T18854 27024-27033 NN denotes occlusion
T18855 27034-27036 IN denotes of
T18856 27037-27040 DT denotes the
T18858 27041-27048 JJ denotes carotid
T18857 27049-27055 NN denotes artery
T18859 27056-27061 IN denotes after
T18860 27062-27067 NN denotes FeCl3
T18861 27068-27074 NN denotes injury
T18862 27074-27075 . denotes .
T18863 27075-27197 sentence denotes After FeCl3 treatment, thrombus formation and occlusion was remarkably shortened in the A/J mice compared to the B6 mice.
T18864 27076-27081 IN denotes After
T18866 27082-27087 NN denotes FeCl3
T18867 27088-27097 NN denotes treatment
T18868 27097-27099 , denotes ,
T18869 27099-27107 NN denotes thrombus
T18870 27108-27117 NN denotes formation
T18871 27118-27121 CC denotes and
T18872 27122-27131 NN denotes occlusion
T18873 27132-27135 VBD denotes was
T18874 27136-27146 RB denotes remarkably
T18865 27147-27156 VBN denotes shortened
T18875 27157-27159 IN denotes in
T18876 27160-27163 DT denotes the
T18878 27164-27165 NN denotes A
T18880 27165-27166 HYPH denotes /
T18879 27166-27167 NN denotes J
T18877 27168-27172 NNS denotes mice
T18881 27173-27181 VBN denotes compared
T18882 27182-27184 IN denotes to
T18883 27185-27188 DT denotes the
T18885 27189-27191 NN denotes B6
T18884 27192-27196 NNS denotes mice
T18886 27196-27197 . denotes .
T18887 27197-27246 sentence denotes These results have not previously been reported.
T18888 27198-27203 DT denotes These
T18889 27204-27211 NNS denotes results
T18891 27212-27216 VBP denotes have
T18892 27217-27220 RB denotes not
T18893 27221-27231 RB denotes previously
T18894 27232-27236 VBN denotes been
T18890 27237-27245 VBN denotes reported
T18895 27245-27246 . denotes .
T18896 27246-27404 sentence denotes A recent study [25] of sheer stress in rats, found that the magnitude of changes in sheer stress with increased blood flow varied with the different strains.
T18897 27247-27248 DT denotes A
T18899 27249-27255 JJ denotes recent
T18898 27256-27261 NN denotes study
T18901 27262-27263 -LRB- denotes [
T18902 27263-27265 CD denotes 25
T18903 27265-27266 -RRB- denotes ]
T18904 27267-27269 IN denotes of
T18905 27270-27275 JJ denotes sheer
T18906 27276-27282 NN denotes stress
T18907 27283-27285 IN denotes in
T18908 27286-27290 NNS denotes rats
T18909 27290-27292 , denotes ,
T18900 27292-27297 VBD denotes found
T18910 27298-27302 IN denotes that
T18912 27303-27306 DT denotes the
T18913 27307-27316 NN denotes magnitude
T18914 27317-27319 IN denotes of
T18915 27320-27327 NNS denotes changes
T18916 27328-27330 IN denotes in
T18917 27331-27336 JJ denotes sheer
T18918 27337-27343 NN denotes stress
T18919 27344-27348 IN denotes with
T18920 27349-27358 VBN denotes increased
T18922 27359-27364 NN denotes blood
T18921 27365-27369 NN denotes flow
T18911 27370-27376 VBD denotes varied
T18923 27377-27381 IN denotes with
T18924 27382-27385 DT denotes the
T18926 27386-27395 JJ denotes different
T18925 27396-27403 NNS denotes strains
T18927 27403-27404 . denotes .
T18928 27404-27619 sentence denotes Further investigation, beyond the scope of this study would be necessary to determine the contribution in the differences in size and sheer stress of the carotids to arterial occlusion rates in the B6 and A/J mice.
T18929 27405-27412 JJ denotes Further
T18930 27413-27426 NN denotes investigation
T18932 27426-27428 , denotes ,
T18933 27428-27434 IN denotes beyond
T18934 27435-27438 DT denotes the
T18935 27439-27444 NN denotes scope
T18936 27445-27447 IN denotes of
T18937 27448-27452 DT denotes this
T18938 27453-27458 NN denotes study
T18939 27459-27464 MD denotes would
T18931 27465-27467 VB denotes be
T18940 27468-27477 JJ denotes necessary
T18941 27478-27480 TO denotes to
T18942 27481-27490 VB denotes determine
T18943 27491-27494 DT denotes the
T18944 27495-27507 NN denotes contribution
T18945 27508-27510 IN denotes in
T18946 27511-27514 DT denotes the
T18947 27515-27526 NNS denotes differences
T18948 27527-27529 IN denotes in
T18949 27530-27534 NN denotes size
T18950 27535-27538 CC denotes and
T18951 27539-27544 JJ denotes sheer
T18952 27545-27551 NN denotes stress
T18953 27552-27554 IN denotes of
T18954 27555-27558 DT denotes the
T18955 27559-27567 NNS denotes carotids
T18956 27568-27570 IN denotes to
T18957 27571-27579 JJ denotes arterial
T18959 27580-27589 NN denotes occlusion
T18958 27590-27595 NNS denotes rates
T18960 27596-27598 IN denotes in
T18961 27599-27602 DT denotes the
T18963 27603-27605 NN denotes B6
T18964 27606-27609 CC denotes and
T18965 27610-27611 NN denotes A
T18967 27611-27612 HYPH denotes /
T18966 27612-27613 NN denotes J
T18962 27614-27618 NNS denotes mice
T18968 27618-27619 . denotes .
T18969 27619-27724 sentence denotes In preliminary studies, we have noted differences in the composition of the thrombus in B6 and A/J mice.
T18970 27620-27622 IN denotes In
T18972 27623-27634 JJ denotes preliminary
T18973 27635-27642 NNS denotes studies
T18974 27642-27644 , denotes ,
T18975 27644-27646 PRP denotes we
T18976 27647-27651 VBP denotes have
T18971 27652-27657 VBN denotes noted
T18977 27658-27669 NNS denotes differences
T18978 27670-27672 IN denotes in
T18979 27673-27676 DT denotes the
T18980 27677-27688 NN denotes composition
T18981 27689-27691 IN denotes of
T18982 27692-27695 DT denotes the
T18983 27696-27704 NN denotes thrombus
T18984 27705-27707 IN denotes in
T18985 27708-27710 NN denotes B6
T18987 27711-27714 CC denotes and
T18988 27715-27716 NN denotes A
T18990 27716-27717 HYPH denotes /
T18989 27717-27718 NN denotes J
T18986 27719-27723 NNS denotes mice
T18991 27723-27724 . denotes .
T18992 27724-27916 sentence denotes The pattern of blood flow cessation for the two inbred strains was different than for the Lepob mice [26] with impaired platelet function, and coagulation time was similar in the two strains.
T18993 27725-27728 DT denotes The
T18994 27729-27736 NN denotes pattern
T18996 27737-27739 IN denotes of
T18997 27740-27745 NN denotes blood
T18998 27746-27750 NN denotes flow
T18999 27751-27760 NN denotes cessation
T19000 27761-27764 IN denotes for
T19001 27765-27768 DT denotes the
T19003 27769-27772 CD denotes two
T19004 27773-27779 JJ denotes inbred
T19002 27780-27787 NNS denotes strains
T18995 27788-27791 VBD denotes was
T19005 27792-27801 JJ denotes different
T19006 27802-27806 IN denotes than
T19007 27807-27810 IN denotes for
T19008 27811-27814 DT denotes the
T19010 27815-27820 NN denotes Lepob
T19009 27821-27825 NNS denotes mice
T19011 27826-27827 -LRB- denotes [
T19012 27827-27829 CD denotes 26
T19013 27829-27830 -RRB- denotes ]
T19014 27831-27835 IN denotes with
T19015 27836-27844 JJ denotes impaired
T19017 27845-27853 NN denotes platelet
T19016 27854-27862 NN denotes function
T19018 27862-27864 , denotes ,
T19019 27864-27867 CC denotes and
T19020 27868-27879 NN denotes coagulation
T19021 27880-27884 NN denotes time
T19022 27885-27888 VBD denotes was
T19023 27889-27896 JJ denotes similar
T19024 27897-27899 IN denotes in
T19025 27900-27903 DT denotes the
T19027 27904-27907 CD denotes two
T19026 27908-27915 NNS denotes strains
T19028 27915-27916 . denotes .
T19029 27916-28210 sentence denotes In the mice with deficiencies of the Plg network [27], thrombus formation time was reduced in the Plg-/- mice, but increased in the PAI-/- mice, suggesting that alterations in plasmin activity that affect the rate of clot lysis, can modulate the events leading to occlusive thrombus formation.
T19030 27917-27919 IN denotes In
T19032 27920-27923 DT denotes the
T19033 27924-27928 NNS denotes mice
T19034 27929-27933 IN denotes with
T19035 27934-27946 NNS denotes deficiencies
T19036 27947-27949 IN denotes of
T19037 27950-27953 DT denotes the
T19039 27954-27957 NN denotes Plg
T19038 27958-27965 NN denotes network
T19040 27966-27967 -LRB- denotes [
T19041 27967-27969 CD denotes 27
T19042 27969-27970 -RRB- denotes ]
T19043 27970-27972 , denotes ,
T19044 27972-27980 NN denotes thrombus
T19045 27981-27990 NN denotes formation
T19046 27991-27995 NN denotes time
T19047 27996-27999 VBD denotes was
T19031 28000-28007 VBN denotes reduced
T19048 28008-28010 IN denotes in
T19049 28011-28014 DT denotes the
T19051 28015-28018 NN denotes Plg
T19052 28018-28019 SYM denotes -
T19053 28019-28020 HYPH denotes /
T19054 28020-28021 SYM denotes -
T19050 28022-28026 NNS denotes mice
T19055 28026-28028 , denotes ,
T19056 28028-28031 CC denotes but
T19057 28032-28041 VBD denotes increased
T19058 28042-28044 IN denotes in
T19059 28045-28048 DT denotes the
T19061 28049-28052 NN denotes PAI
T19062 28052-28053 SYM denotes -
T19063 28053-28054 HYPH denotes /
T19064 28054-28055 SYM denotes -
T19060 28056-28060 NNS denotes mice
T19065 28060-28062 , denotes ,
T19066 28062-28072 VBG denotes suggesting
T19067 28073-28077 IN denotes that
T19069 28078-28089 NNS denotes alterations
T19070 28090-28092 IN denotes in
T19071 28093-28100 NN denotes plasmin
T19072 28101-28109 NN denotes activity
T19073 28110-28114 WDT denotes that
T19074 28115-28121 VBP denotes affect
T19075 28122-28125 DT denotes the
T19076 28126-28130 NN denotes rate
T19077 28131-28133 IN denotes of
T19078 28134-28138 NN denotes clot
T19079 28139-28144 NN denotes lysis
T19080 28144-28146 , denotes ,
T19081 28146-28149 MD denotes can
T19068 28150-28158 VB denotes modulate
T19082 28159-28162 DT denotes the
T19083 28163-28169 NNS denotes events
T19084 28170-28177 VBG denotes leading
T19085 28178-28180 IN denotes to
T19086 28181-28190 JJ denotes occlusive
T19087 28191-28199 NN denotes thrombus
T19088 28200-28209 NN denotes formation
T19089 28209-28210 . denotes .
T19090 28210-28371 sentence denotes The tail-bleeding assay has been used extensively in mice to assess the impact of deficiencies and over expression of platelet and coagulation proteins in mice.
T19091 28211-28214 DT denotes The
T19093 28215-28219 NN denotes tail
T19095 28219-28220 HYPH denotes -
T19094 28220-28228 NN denotes bleeding
T19092 28229-28234 NN denotes assay
T19097 28235-28238 VBZ denotes has
T19098 28239-28243 VBN denotes been
T19096 28244-28248 VBN denotes used
T19099 28249-28260 RB denotes extensively
T19100 28261-28263 IN denotes in
T19101 28264-28268 NNS denotes mice
T19102 28269-28271 TO denotes to
T19103 28272-28278 VB denotes assess
T19104 28279-28282 DT denotes the
T19105 28283-28289 NN denotes impact
T19106 28290-28292 IN denotes of
T19107 28293-28305 NNS denotes deficiencies
T19108 28306-28309 CC denotes and
T19109 28310-28314 RB denotes over
T19110 28315-28325 NN denotes expression
T19111 28326-28328 IN denotes of
T19112 28329-28337 NN denotes platelet
T19114 28338-28341 CC denotes and
T19115 28342-28353 NN denotes coagulation
T19113 28354-28362 NN denotes proteins
T19116 28363-28365 IN denotes in
T19117 28366-28370 NNS denotes mice
T19118 28370-28371 . denotes .
T19119 28371-28519 sentence denotes Sweeny et al [28] screened 25 strains of mice and found only the RIIS/J mice to have increased bleeding time due to reduced von Willebrand antigen.
T19120 28372-28378 NNP denotes Sweeny
T19122 28379-28381 FW denotes et
T19123 28382-28384 FW denotes al
T19124 28385-28386 -LRB- denotes [
T19125 28386-28388 CD denotes 28
T19126 28388-28389 -RRB- denotes ]
T19121 28390-28398 VBD denotes screened
T19127 28399-28401 CD denotes 25
T19128 28402-28409 NNS denotes strains
T19129 28410-28412 IN denotes of
T19130 28413-28417 NNS denotes mice
T19131 28418-28421 CC denotes and
T19132 28422-28427 VBN denotes found
T19133 28428-28432 RB denotes only
T19135 28433-28436 DT denotes the
T19136 28437-28441 NN denotes RIIS
T19138 28441-28442 HYPH denotes /
T19137 28442-28443 NN denotes J
T19134 28444-28448 NNS denotes mice
T19140 28449-28451 TO denotes to
T19139 28452-28456 VB denotes have
T19141 28457-28466 VBN denotes increased
T19143 28467-28475 NN denotes bleeding
T19142 28476-28480 NN denotes time
T19144 28481-28484 IN denotes due
T19145 28485-28487 IN denotes to
T19146 28488-28495 VBN denotes reduced
T19148 28496-28499 NNP denotes von
T19149 28500-28510 NNP denotes Willebrand
T19147 28511-28518 NN denotes antigen
T19150 28518-28519 . denotes .
T19151 28519-28741 sentence denotes Broze et al [29] evaluated mice with gene deletions of the coagulation pathway and found that while bleeding time was not increased, rebleeding persisted despite electrocautery of the tail in FVIII and FIX deficient mice.
T19152 28520-28525 NNP denotes Broze
T19154 28526-28528 FW denotes et
T19155 28529-28531 FW denotes al
T19156 28532-28533 -LRB- denotes [
T19157 28533-28535 CD denotes 29
T19158 28535-28536 -RRB- denotes ]
T19153 28537-28546 VBN denotes evaluated
T19159 28547-28551 NNS denotes mice
T19160 28552-28556 IN denotes with
T19161 28557-28561 NN denotes gene
T19162 28562-28571 NNS denotes deletions
T19163 28572-28574 IN denotes of
T19164 28575-28578 DT denotes the
T19166 28579-28590 NN denotes coagulation
T19165 28591-28598 NN denotes pathway
T19167 28599-28602 CC denotes and
T19168 28603-28608 VBD denotes found
T19169 28609-28613 IN denotes that
T19171 28614-28619 IN denotes while
T19173 28620-28628 NN denotes bleeding
T19174 28629-28633 NN denotes time
T19175 28634-28637 VBD denotes was
T19176 28638-28641 RB denotes not
T19172 28642-28651 VBN denotes increased
T19177 28651-28653 , denotes ,
T19178 28653-28663 NN denotes rebleeding
T19170 28664-28673 VBD denotes persisted
T19179 28674-28681 IN denotes despite
T19180 28682-28696 NN denotes electrocautery
T19181 28697-28699 IN denotes of
T19182 28700-28703 DT denotes the
T19183 28704-28708 NN denotes tail
T19184 28709-28711 IN denotes in
T19185 28712-28717 NN denotes FVIII
T19187 28718-28721 CC denotes and
T19188 28722-28725 NN denotes FIX
T19186 28726-28735 JJ denotes deficient
T19189 28736-28740 NNS denotes mice
T19190 28740-28741 . denotes .
T19191 28741-28889 sentence denotes This observation raised the possibility that rebleeding time may be a sensitive reporter of genetic influences on thrombus formation and stability.
T19192 28742-28746 DT denotes This
T19193 28747-28758 NN denotes observation
T19194 28759-28765 VBD denotes raised
T19195 28766-28769 DT denotes the
T19196 28770-28781 NN denotes possibility
T19197 28782-28786 IN denotes that
T19199 28787-28797 NN denotes rebleeding
T19200 28798-28802 NN denotes time
T19201 28803-28806 MD denotes may
T19198 28807-28809 VB denotes be
T19202 28810-28811 DT denotes a
T19204 28812-28821 JJ denotes sensitive
T19203 28822-28830 NN denotes reporter
T19205 28831-28833 IN denotes of
T19206 28834-28841 JJ denotes genetic
T19207 28842-28852 NNS denotes influences
T19208 28853-28855 IN denotes on
T19209 28856-28864 NN denotes thrombus
T19210 28865-28874 NN denotes formation
T19211 28875-28878 CC denotes and
T19212 28879-28888 NN denotes stability
T19213 28888-28889 . denotes .
T19214 28889-29069 sentence denotes Mice that are deficient in factors required for normal platelet function, platelet glycoprotein Ib [30], and protease-activated receptor-4, [31] have increased tail bleeding time.
T19215 28890-28894 NNS denotes Mice
T19217 28895-28899 WDT denotes that
T19218 28900-28903 VBP denotes are
T19219 28904-28913 JJ denotes deficient
T19220 28914-28916 IN denotes in
T19221 28917-28924 NNS denotes factors
T19222 28925-28933 VBN denotes required
T19223 28934-28937 IN denotes for
T19224 28938-28944 JJ denotes normal
T19226 28945-28953 NN denotes platelet
T19225 28954-28962 NN denotes function
T19227 28962-28964 , denotes ,
T19228 28964-28972 NN denotes platelet
T19230 28973-28985 NN denotes glycoprotein
T19229 28986-28988 NN denotes Ib
T19231 28989-28990 -LRB- denotes [
T19232 28990-28992 CD denotes 30
T19233 28992-28993 -RRB- denotes ]
T19234 28993-28995 , denotes ,
T19235 28995-28998 CC denotes and
T19236 28999-29007 NN denotes protease
T19238 29007-29008 HYPH denotes -
T19237 29008-29017 VBN denotes activated
T19239 29018-29026 NN denotes receptor
T19240 29026-29027 HYPH denotes -
T19241 29027-29028 CD denotes 4
T19242 29028-29030 , denotes ,
T19243 29030-29031 -LRB- denotes [
T19244 29031-29033 CD denotes 31
T19245 29033-29034 -RRB- denotes ]
T19246 29035-29039 VBP denotes have
T19216 29040-29049 VBN denotes increased
T19247 29050-29054 NN denotes tail
T19248 29055-29063 NN denotes bleeding
T19249 29064-29068 NN denotes time
T19250 29068-29069 . denotes .
T19251 29069-29340 sentence denotes The leptin deficiency with reduced platelet aggregation clearly shows a marked increase in bleeding time and the increased bleeding time in Plg-/- and uPA-/- mice suggests that Plg and uPA may exert an influence on platelet response to promote normal thrombus formation.
T19252 29070-29073 DT denotes The
T19254 29074-29080 NN denotes leptin
T19253 29081-29091 NN denotes deficiency
T19256 29092-29096 IN denotes with
T19257 29097-29104 VBN denotes reduced
T19259 29105-29113 NN denotes platelet
T19258 29114-29125 NN denotes aggregation
T19260 29126-29133 RB denotes clearly
T19255 29134-29139 VBZ denotes shows
T19261 29140-29141 DT denotes a
T19263 29142-29148 JJ denotes marked
T19262 29149-29157 NN denotes increase
T19264 29158-29160 IN denotes in
T19265 29161-29169 NN denotes bleeding
T19266 29170-29174 NN denotes time
T19267 29175-29178 CC denotes and
T19268 29179-29182 DT denotes the
T19270 29183-29192 VBN denotes increased
T19271 29193-29201 NN denotes bleeding
T19269 29202-29206 NN denotes time
T19273 29207-29209 IN denotes in
T19274 29210-29213 NN denotes Plg
T19276 29213-29214 SYM denotes -
T19277 29214-29215 HYPH denotes /
T19278 29215-29216 SYM denotes -
T19279 29217-29220 CC denotes and
T19280 29221-29224 NN denotes uPA
T19281 29224-29225 SYM denotes -
T19282 29225-29226 HYPH denotes /
T19283 29226-29227 SYM denotes -
T19275 29228-29232 NNS denotes mice
T19272 29233-29241 VBZ denotes suggests
T19284 29242-29246 IN denotes that
T19286 29247-29250 NN denotes Plg
T19287 29251-29254 CC denotes and
T19288 29255-29258 NN denotes uPA
T19289 29259-29262 MD denotes may
T19285 29263-29268 VB denotes exert
T19290 29269-29271 DT denotes an
T19291 29272-29281 NN denotes influence
T19292 29282-29284 IN denotes on
T19293 29285-29293 NN denotes platelet
T19294 29294-29302 NN denotes response
T19295 29303-29305 TO denotes to
T19296 29306-29313 VB denotes promote
T19297 29314-29320 JJ denotes normal
T19299 29321-29329 NN denotes thrombus
T19298 29330-29339 NN denotes formation
T19300 29339-29340 . denotes .
T19301 29340-29519 sentence denotes Overall, the marked increase in rebleeding times observed in certain mouse strains suggests genetic factors other than coagulation may play a role in the stability of a thrombus.
T19302 29341-29348 RB denotes Overall
T19304 29348-29350 , denotes ,
T19305 29350-29353 DT denotes the
T19307 29354-29360 JJ denotes marked
T19306 29361-29369 NN denotes increase
T19308 29370-29372 IN denotes in
T19309 29373-29383 NN denotes rebleeding
T19310 29384-29389 NNS denotes times
T19311 29390-29398 VBN denotes observed
T19312 29399-29401 IN denotes in
T19313 29402-29409 JJ denotes certain
T19315 29410-29415 NN denotes mouse
T19314 29416-29423 NNS denotes strains
T19303 29424-29432 VBZ denotes suggests
T19316 29433-29440 JJ denotes genetic
T19317 29441-29448 NNS denotes factors
T19319 29449-29454 JJ denotes other
T19320 29455-29459 IN denotes than
T19321 29460-29471 NN denotes coagulation
T19322 29472-29475 MD denotes may
T19318 29476-29480 VB denotes play
T19323 29481-29482 DT denotes a
T19324 29483-29487 NN denotes role
T19325 29488-29490 IN denotes in
T19326 29491-29494 DT denotes the
T19327 29495-29504 NN denotes stability
T19328 29505-29507 IN denotes of
T19329 29508-29509 DT denotes a
T19330 29510-29518 NN denotes thrombus
T19331 29518-29519 . denotes .
T19332 29519-29647 sentence denotes In the tail bleeding assay, A/J mice did not have changes in bleeding time, but rebleeding time was higher compared to B6 mice.
T19333 29520-29522 IN denotes In
T19335 29523-29526 DT denotes the
T19337 29527-29531 NN denotes tail
T19338 29532-29540 NN denotes bleeding
T19336 29541-29546 NN denotes assay
T19339 29546-29548 , denotes ,
T19340 29548-29549 NN denotes A
T19342 29549-29550 HYPH denotes /
T19341 29550-29551 NN denotes J
T19343 29552-29556 NNS denotes mice
T19344 29557-29560 VBD denotes did
T19345 29561-29564 RB denotes not
T19334 29565-29569 VB denotes have
T19346 29570-29577 NNS denotes changes
T19347 29578-29580 IN denotes in
T19348 29581-29589 NN denotes bleeding
T19349 29590-29594 NN denotes time
T19350 29594-29596 , denotes ,
T19351 29596-29599 CC denotes but
T19352 29600-29610 NN denotes rebleeding
T19353 29611-29615 NN denotes time
T19354 29616-29619 VBD denotes was
T19355 29620-29626 JJR denotes higher
T19356 29627-29635 VBN denotes compared
T19357 29636-29638 IN denotes to
T19358 29639-29641 NN denotes B6
T19359 29642-29646 NNS denotes mice
T19360 29646-29647 . denotes .
T19361 29647-29881 sentence denotes In our study, Plg-/- mice had increased bleeding time, PAI-1-/- had decreased rebleeding time, and uPA-/- mice had an increased bleeding time similar to the Plg-/- mice (J. Hoover-Plow, A. Shchurin, and E. Hart, unpublished results).
T19362 29648-29650 IN denotes In
T19364 29651-29654 PRP$ denotes our
T19365 29655-29660 NN denotes study
T19366 29660-29662 , denotes ,
T19367 29662-29665 NN denotes Plg
T19369 29665-29666 SYM denotes -
T19370 29666-29667 HYPH denotes /
T19371 29667-29668 SYM denotes -
T19368 29669-29673 NNS denotes mice
T19363 29674-29677 VBD denotes had
T19372 29678-29687 VBN denotes increased
T19374 29688-29696 NN denotes bleeding
T19373 29697-29701 NN denotes time
T19375 29701-29703 , denotes ,
T19376 29703-29706 NN denotes PAI
T19378 29706-29707 HYPH denotes -
T19379 29707-29708 CD denotes 1
T19380 29708-29709 SYM denotes -
T19381 29709-29710 HYPH denotes /
T19382 29710-29711 SYM denotes -
T19377 29712-29715 VBD denotes had
T19383 29716-29725 VBN denotes decreased
T19385 29726-29736 NN denotes rebleeding
T19384 29737-29741 NN denotes time
T19386 29741-29743 , denotes ,
T19387 29743-29746 CC denotes and
T19388 29747-29750 NN denotes uPA
T19390 29750-29751 SYM denotes -
T19391 29751-29752 HYPH denotes /
T19392 29752-29753 SYM denotes -
T19389 29754-29758 NNS denotes mice
T19393 29759-29762 VBD denotes had
T19394 29763-29765 DT denotes an
T19396 29766-29775 VBN denotes increased
T19397 29776-29784 NN denotes bleeding
T19395 29785-29789 NN denotes time
T19398 29790-29797 JJ denotes similar
T19399 29798-29800 IN denotes to
T19400 29801-29804 DT denotes the
T19402 29805-29808 NN denotes Plg
T19403 29808-29809 SYM denotes -
T19404 29809-29810 HYPH denotes /
T19405 29810-29811 SYM denotes -
T19401 29812-29816 NNS denotes mice
T19406 29817-29818 -LRB- denotes (
T19407 29818-29820 NNP denotes J.
T19408 29821-29827 NNP denotes Hoover
T19409 29827-29828 HYPH denotes -
T19410 29828-29832 NNP denotes Plow
T19411 29832-29834 , denotes ,
T19412 29834-29836 NNP denotes A.
T19413 29837-29845 NNP denotes Shchurin
T19414 29845-29847 , denotes ,
T19415 29847-29850 CC denotes and
T19416 29851-29853 NNP denotes E.
T19417 29854-29858 NNP denotes Hart
T19418 29858-29860 , denotes ,
T19419 29860-29871 JJ denotes unpublished
T19420 29872-29879 NNS denotes results
T19421 29879-29880 -RRB- denotes )
T19422 29880-29881 . denotes .
T19423 29881-29984 sentence denotes Increased bleeding or rebleeding times have not been reported in any of the Plg network targeted mice.
T19424 29882-29891 VBN denotes Increased
T19426 29892-29900 NN denotes bleeding
T19427 29901-29903 CC denotes or
T19428 29904-29914 NN denotes rebleeding
T19425 29915-29920 NNS denotes times
T19430 29921-29925 VBP denotes have
T19431 29926-29929 RB denotes not
T19432 29930-29934 VBN denotes been
T19429 29935-29943 VBN denotes reported
T19433 29944-29946 IN denotes in
T19434 29947-29950 DT denotes any
T19435 29951-29953 IN denotes of
T19436 29954-29957 DT denotes the
T19438 29958-29961 NN denotes Plg
T19439 29962-29969 NN denotes network
T19440 29970-29978 VBN denotes targeted
T19437 29979-29983 NNS denotes mice
T19441 29983-29984 . denotes .
T19442 29984-30248 sentence denotes Matsuno et al [32] reported no difference in bleeding time for tPA-/-, uPA-/-, PAI-1-/- mice compared to WT mice, and the assay was similar, but the tail clip segment was considerably shorter and bleeding times reduced compared to the times reported in our study.
T19443 29985-29992 NNP denotes Matsuno
T19445 29993-29995 FW denotes et
T19446 29996-29998 FW denotes al
T19447 29999-30000 -LRB- denotes [
T19448 30000-30002 CD denotes 32
T19449 30002-30003 -RRB- denotes ]
T19444 30004-30012 VBD denotes reported
T19450 30013-30015 DT denotes no
T19451 30016-30026 NN denotes difference
T19452 30027-30029 IN denotes in
T19453 30030-30038 NN denotes bleeding
T19454 30039-30043 NN denotes time
T19455 30044-30047 IN denotes for
T19456 30048-30051 NN denotes tPA
T19458 30051-30052 SYM denotes -
T19459 30052-30053 HYPH denotes /
T19460 30053-30054 SYM denotes -
T19461 30054-30056 , denotes ,
T19462 30056-30059 NN denotes uPA
T19463 30059-30060 SYM denotes -
T19464 30060-30061 HYPH denotes /
T19465 30061-30062 SYM denotes -
T19466 30062-30064 , denotes ,
T19467 30064-30067 NN denotes PAI
T19468 30067-30068 HYPH denotes -
T19469 30068-30069 CD denotes 1
T19470 30069-30070 SYM denotes -
T19471 30070-30071 HYPH denotes /
T19472 30071-30072 SYM denotes -
T19457 30073-30077 NNS denotes mice
T19473 30078-30086 VBN denotes compared
T19474 30087-30089 IN denotes to
T19475 30090-30092 NN denotes WT
T19476 30093-30097 NNS denotes mice
T19477 30097-30099 , denotes ,
T19478 30099-30102 CC denotes and
T19479 30103-30106 DT denotes the
T19480 30107-30112 NN denotes assay
T19481 30113-30116 VBD denotes was
T19482 30117-30124 JJ denotes similar
T19483 30124-30126 , denotes ,
T19484 30126-30129 CC denotes but
T19485 30130-30133 DT denotes the
T19487 30134-30138 NN denotes tail
T19488 30139-30143 NN denotes clip
T19486 30144-30151 NN denotes segment
T19489 30152-30155 VBD denotes was
T19490 30156-30168 RB denotes considerably
T19491 30169-30176 JJR denotes shorter
T19492 30177-30180 CC denotes and
T19493 30181-30189 NN denotes bleeding
T19494 30190-30195 NNS denotes times
T19495 30196-30203 JJ denotes reduced
T19496 30204-30212 VBN denotes compared
T19497 30213-30215 IN denotes to
T19498 30216-30219 DT denotes the
T19499 30220-30225 NNS denotes times
T19500 30226-30234 VBN denotes reported
T19501 30235-30237 IN denotes in
T19502 30238-30241 PRP$ denotes our
T19503 30242-30247 NN denotes study
T19504 30247-30248 . denotes .
T19505 30248-30312 sentence denotes Bleeding time has not been previously reported for Plg-/- mice.
T19506 30249-30257 NN denotes Bleeding
T19507 30258-30262 NN denotes time
T19509 30263-30266 VBZ denotes has
T19510 30267-30270 RB denotes not
T19511 30271-30275 VBN denotes been
T19512 30276-30286 RB denotes previously
T19508 30287-30295 VBN denotes reported
T19513 30296-30299 IN denotes for
T19514 30300-30303 NN denotes Plg
T19516 30303-30304 SYM denotes -
T19517 30304-30305 HYPH denotes /
T19518 30305-30306 SYM denotes -
T19515 30307-30311 NNS denotes mice
T19519 30311-30312 . denotes .
T19520 30312-30451 sentence denotes We have found similar values for Plg-/- mice in a 50%B6:50%129 background (J. Hoover-Plow, A. Shchurin, and E. Hart, unpublished results).
T19521 30313-30315 PRP denotes We
T19523 30316-30320 VBP denotes have
T19522 30321-30326 VBN denotes found
T19524 30327-30334 JJ denotes similar
T19525 30335-30341 NNS denotes values
T19526 30342-30345 IN denotes for
T19527 30346-30349 NN denotes Plg
T19529 30349-30350 SYM denotes -
T19530 30350-30351 HYPH denotes /
T19531 30351-30352 SYM denotes -
T19528 30353-30357 NNS denotes mice
T19532 30358-30360 IN denotes in
T19533 30361-30362 DT denotes a
T19535 30363-30365 CD denotes 50
T19536 30365-30366 NN denotes %
T19537 30366-30368 NN denotes B6
T19538 30368-30369 : denotes :
T19539 30369-30371 CD denotes 50
T19540 30371-30372 NN denotes %
T19541 30372-30375 CD denotes 129
T19534 30376-30386 NN denotes background
T19542 30387-30388 -LRB- denotes (
T19543 30388-30390 NNP denotes J.
T19544 30391-30397 NNP denotes Hoover
T19545 30397-30398 HYPH denotes -
T19546 30398-30402 NNP denotes Plow
T19547 30402-30404 , denotes ,
T19548 30404-30406 NNP denotes A.
T19549 30407-30415 NNP denotes Shchurin
T19550 30415-30417 , denotes ,
T19551 30417-30420 CC denotes and
T19552 30421-30423 NNP denotes E.
T19553 30424-30428 NNP denotes Hart
T19554 30428-30430 , denotes ,
T19555 30430-30441 JJ denotes unpublished
T19556 30442-30449 NNS denotes results
T19557 30449-30450 -RRB- denotes )
T19558 30450-30451 . denotes .
T19559 30451-30616 sentence denotes The results of this study suggest that not only is bleeding time genetically determined by background, but also that tail rebleeding time is genetically determined.
T19560 30452-30455 DT denotes The
T19561 30456-30463 NNS denotes results
T19563 30464-30466 IN denotes of
T19564 30467-30471 DT denotes this
T19565 30472-30477 NN denotes study
T19562 30478-30485 VBP denotes suggest
T19566 30486-30490 IN denotes that
T19568 30491-30494 RB denotes not
T19569 30495-30499 RB denotes only
T19570 30500-30502 VBZ denotes is
T19571 30503-30511 NN denotes bleeding
T19572 30512-30516 NN denotes time
T19573 30517-30528 RB denotes genetically
T19567 30529-30539 VBN denotes determined
T19574 30540-30542 IN denotes by
T19575 30543-30553 NN denotes background
T19576 30553-30555 , denotes ,
T19577 30555-30558 CC denotes but
T19578 30559-30563 RB denotes also
T19579 30564-30568 IN denotes that
T19581 30569-30573 NN denotes tail
T19582 30574-30584 NN denotes rebleeding
T19583 30585-30589 NN denotes time
T19584 30590-30592 VBZ denotes is
T19585 30593-30604 RB denotes genetically
T19580 30605-30615 VBN denotes determined
T19586 30615-30616 . denotes .
T19587 30616-30758 sentence denotes While blood pressure could conceivably be higher in mice with elevated tail bleeding time, several studies suggest that this is not the case.
T19588 30617-30622 IN denotes While
T19590 30623-30628 NN denotes blood
T19591 30629-30637 NN denotes pressure
T19592 30638-30643 MD denotes could
T19593 30644-30655 RB denotes conceivably
T19589 30656-30658 VB denotes be
T19595 30659-30665 JJR denotes higher
T19596 30666-30668 IN denotes in
T19597 30669-30673 NNS denotes mice
T19598 30674-30678 IN denotes with
T19599 30679-30687 VBN denotes elevated
T19601 30688-30692 NN denotes tail
T19602 30693-30701 NN denotes bleeding
T19600 30702-30706 NN denotes time
T19603 30706-30708 , denotes ,
T19604 30708-30715 JJ denotes several
T19605 30716-30723 NNS denotes studies
T19594 30724-30731 VBP denotes suggest
T19606 30732-30736 IN denotes that
T19608 30737-30741 DT denotes this
T19607 30742-30744 VBZ denotes is
T19609 30745-30748 RB denotes not
T19610 30749-30752 DT denotes the
T19611 30753-30757 NN denotes case
T19612 30757-30758 . denotes .
T19613 30758-30874 sentence denotes Studies of A/J [33-36] mice have reported either decreased blood pressure or no difference compared to the B6 mice.
T19614 30759-30766 NNS denotes Studies
T19616 30767-30769 IN denotes of
T19617 30770-30771 NN denotes A
T19619 30771-30772 HYPH denotes /
T19618 30772-30773 NN denotes J
T19621 30774-30775 -LRB- denotes [
T19622 30775-30777 CD denotes 33
T19623 30777-30778 SYM denotes -
T19624 30778-30780 CD denotes 36
T19625 30780-30781 -RRB- denotes ]
T19620 30782-30786 NNS denotes mice
T19626 30787-30791 VBP denotes have
T19615 30792-30800 VBN denotes reported
T19627 30801-30807 CC denotes either
T19629 30808-30817 VBN denotes decreased
T19630 30818-30823 NN denotes blood
T19628 30824-30832 NN denotes pressure
T19631 30833-30835 CC denotes or
T19632 30836-30838 DT denotes no
T19633 30839-30849 NN denotes difference
T19634 30850-30858 VBN denotes compared
T19635 30859-30861 IN denotes to
T19636 30862-30865 DT denotes the
T19638 30866-30868 NN denotes B6
T19637 30869-30873 NNS denotes mice
T19639 30873-30874 . denotes .
T19640 30874-31227 sentence denotes Blood pressure was measured in the Plg-/- mice (D. Hellard, J. Hoover-Plow, and E. Plow, unpublished results), and these mice have reduced blood pressure when compared to WT littermates, and uPA-/- [37] and Lepob [38,39] mice also have reduced blood pressure, but there is no correspondence between blood pressure and tail bleeding or rebleeding times.
T19641 30875-30880 NN denotes Blood
T19642 30881-30889 NN denotes pressure
T19644 30890-30893 VBD denotes was
T19643 30894-30902 VBN denotes measured
T19645 30903-30905 IN denotes in
T19646 30906-30909 DT denotes the
T19648 30910-30913 NN denotes Plg
T19649 30913-30914 SYM denotes -
T19650 30914-30915 HYPH denotes /
T19651 30915-30916 SYM denotes -
T19647 30917-30921 NNS denotes mice
T19652 30922-30923 -LRB- denotes (
T19653 30923-30925 NNP denotes D.
T19654 30926-30933 NNP denotes Hellard
T19655 30933-30935 , denotes ,
T19656 30935-30937 NNP denotes J.
T19657 30938-30944 NNP denotes Hoover
T19658 30944-30945 HYPH denotes -
T19659 30945-30949 NNP denotes Plow
T19660 30949-30951 , denotes ,
T19661 30951-30954 CC denotes and
T19662 30955-30957 NNP denotes E.
T19663 30958-30962 NNP denotes Plow
T19664 30962-30964 , denotes ,
T19665 30964-30975 JJ denotes unpublished
T19666 30976-30983 NNS denotes results
T19667 30983-30984 -RRB- denotes )
T19668 30984-30986 , denotes ,
T19669 30986-30989 CC denotes and
T19670 30990-30995 DT denotes these
T19671 30996-31000 NNS denotes mice
T19672 31001-31005 VBP denotes have
T19673 31006-31013 VBN denotes reduced
T19675 31014-31019 NN denotes blood
T19674 31020-31028 NN denotes pressure
T19676 31029-31033 WRB denotes when
T19677 31034-31042 VBN denotes compared
T19678 31043-31045 IN denotes to
T19679 31046-31048 JJ denotes WT
T19680 31049-31060 NNS denotes littermates
T19681 31060-31062 , denotes ,
T19682 31062-31065 CC denotes and
T19683 31066-31069 NN denotes uPA
T19685 31069-31070 SYM denotes -
T19686 31070-31071 HYPH denotes /
T19687 31071-31072 SYM denotes -
T19688 31073-31074 -LRB- denotes [
T19689 31074-31076 CD denotes 37
T19690 31076-31077 -RRB- denotes ]
T19691 31078-31081 CC denotes and
T19692 31082-31087 NN denotes Lepob
T19693 31088-31089 -LRB- denotes [
T19695 31089-31091 CD denotes 38
T19696 31091-31092 , denotes ,
T19694 31092-31094 CD denotes 39
T19697 31094-31095 -RRB- denotes ]
T19684 31096-31100 NNS denotes mice
T19699 31101-31105 RB denotes also
T19698 31106-31110 VBP denotes have
T19700 31111-31118 VBN denotes reduced
T19702 31119-31124 NN denotes blood
T19701 31125-31133 NN denotes pressure
T19703 31133-31135 , denotes ,
T19704 31135-31138 CC denotes but
T19705 31139-31144 EX denotes there
T19706 31145-31147 VBZ denotes is
T19707 31148-31150 DT denotes no
T19708 31151-31165 NN denotes correspondence
T19709 31166-31173 IN denotes between
T19710 31174-31179 NN denotes blood
T19711 31180-31188 NN denotes pressure
T19712 31189-31192 CC denotes and
T19713 31193-31197 NN denotes tail
T19715 31198-31206 NN denotes bleeding
T19716 31207-31209 CC denotes or
T19717 31210-31220 NN denotes rebleeding
T19714 31221-31226 NNS denotes times
T19718 31226-31227 . denotes .
T19719 31227-31337 sentence denotes Morphometric analysis of the tail indicated a difference in the collagen content of the tail in the A/J mice.
T19720 31228-31240 JJ denotes Morphometric
T19721 31241-31249 NN denotes analysis
T19723 31250-31252 IN denotes of
T19724 31253-31256 DT denotes the
T19725 31257-31261 NN denotes tail
T19722 31262-31271 VBD denotes indicated
T19726 31272-31273 DT denotes a
T19727 31274-31284 NN denotes difference
T19728 31285-31287 IN denotes in
T19729 31288-31291 DT denotes the
T19731 31292-31300 NN denotes collagen
T19730 31301-31308 NN denotes content
T19732 31309-31311 IN denotes of
T19733 31312-31315 DT denotes the
T19734 31316-31320 NN denotes tail
T19735 31321-31323 IN denotes in
T19736 31324-31327 DT denotes the
T19738 31328-31329 NN denotes A
T19740 31329-31330 HYPH denotes /
T19739 31330-31331 NN denotes J
T19737 31332-31336 NNS denotes mice
T19741 31336-31337 . denotes .
T19742 31337-31550 sentence denotes Differences in the structure and/or metabolism of collagen or extracellular matrix proteins may contribute to the increased rebleeding and reduced occlusion time in the A/J mice and warrant further investigation.
T19743 31338-31349 NNS denotes Differences
T19745 31350-31352 IN denotes in
T19746 31353-31356 DT denotes the
T19747 31357-31366 NN denotes structure
T19748 31367-31370 CC denotes and
T19749 31370-31371 HYPH denotes /
T19750 31371-31373 CC denotes or
T19751 31374-31384 NN denotes metabolism
T19752 31385-31387 IN denotes of
T19753 31388-31396 NN denotes collagen
T19754 31397-31399 CC denotes or
T19755 31400-31413 JJ denotes extracellular
T19757 31414-31420 NN denotes matrix
T19756 31421-31429 NN denotes proteins
T19758 31430-31433 MD denotes may
T19744 31434-31444 VB denotes contribute
T19759 31445-31447 IN denotes to
T19760 31448-31451 DT denotes the
T19762 31452-31461 VBN denotes increased
T19763 31462-31472 NN denotes rebleeding
T19764 31473-31476 CC denotes and
T19765 31477-31484 VBD denotes reduced
T19766 31485-31494 NN denotes occlusion
T19761 31495-31499 NN denotes time
T19767 31500-31502 IN denotes in
T19768 31503-31506 DT denotes the
T19770 31507-31508 NN denotes A
T19772 31508-31509 HYPH denotes /
T19771 31509-31510 NN denotes J
T19769 31511-31515 NNS denotes mice
T19773 31516-31519 CC denotes and
T19774 31520-31527 VB denotes warrant
T19775 31528-31535 JJ denotes further
T19776 31536-31549 NN denotes investigation
T19777 31549-31550 . denotes .
T19778 31550-31759 sentence denotes The genes for Plg, PAI-1, and α2-antiplasmin reside on the three chromosomes identified for QTL for rebleeding time and may or may not be coincidental to the observed phenotypes found in the A/J mice and CSS.
T19779 31551-31554 DT denotes The
T19780 31555-31560 NNS denotes genes
T19782 31561-31564 IN denotes for
T19783 31565-31568 NN denotes Plg
T19784 31568-31570 , denotes ,
T19785 31570-31573 NN denotes PAI
T19786 31573-31574 HYPH denotes -
T19787 31574-31575 CD denotes 1
T19788 31575-31577 , denotes ,
T19789 31577-31580 CC denotes and
T19790 31581-31583 NN denotes α2
T19792 31583-31584 HYPH denotes -
T19791 31584-31595 NN denotes antiplasmin
T19781 31596-31602 VBP denotes reside
T19793 31603-31605 IN denotes on
T19794 31606-31609 DT denotes the
T19796 31610-31615 CD denotes three
T19795 31616-31627 NNS denotes chromosomes
T19797 31628-31638 VBN denotes identified
T19798 31639-31642 IN denotes for
T19799 31643-31646 NN denotes QTL
T19800 31647-31650 IN denotes for
T19801 31651-31661 NN denotes rebleeding
T19802 31662-31666 NN denotes time
T19803 31667-31670 CC denotes and
T19804 31671-31674 MD denotes may
T19805 31675-31677 CC denotes or
T19806 31678-31681 MD denotes may
T19807 31682-31685 RB denotes not
T19808 31686-31688 VB denotes be
T19809 31689-31701 JJ denotes coincidental
T19810 31702-31704 IN denotes to
T19811 31705-31708 DT denotes the
T19813 31709-31717 VBN denotes observed
T19812 31718-31728 NNS denotes phenotypes
T19814 31729-31734 VBN denotes found
T19815 31735-31737 IN denotes in
T19816 31738-31741 DT denotes the
T19818 31742-31743 NN denotes A
T19819 31743-31744 HYPH denotes /
T19817 31744-31745 NN denotes J
T19820 31746-31750 NNS denotes mice
T19821 31751-31754 CC denotes and
T19822 31755-31758 NNS denotes CSS
T19823 31758-31759 . denotes .
T19824 31759-31918 sentence denotes It is not likely that merely the concentration of these components explains the increased rebleeding time and reduced arterial occlusion time in the A/J mice.
T19825 31760-31762 PRP denotes It
T19826 31763-31765 VBZ denotes is
T19827 31766-31769 RB denotes not
T19828 31770-31776 JJ denotes likely
T19829 31777-31781 IN denotes that
T19831 31782-31788 RB denotes merely
T19833 31789-31792 DT denotes the
T19832 31793-31806 NN denotes concentration
T19834 31807-31809 IN denotes of
T19835 31810-31815 DT denotes these
T19836 31816-31826 NNS denotes components
T19830 31827-31835 VBZ denotes explains
T19837 31836-31839 DT denotes the
T19839 31840-31849 VBN denotes increased
T19840 31850-31860 NN denotes rebleeding
T19838 31861-31865 NN denotes time
T19841 31866-31869 CC denotes and
T19842 31870-31877 VBN denotes reduced
T19844 31878-31886 JJ denotes arterial
T19845 31887-31896 NN denotes occlusion
T19843 31897-31901 NN denotes time
T19846 31902-31904 IN denotes in
T19847 31905-31908 DT denotes the
T19849 31909-31910 NN denotes A
T19851 31910-31911 HYPH denotes /
T19850 31911-31912 NN denotes J
T19848 31913-31917 NNS denotes mice
T19852 31917-31918 . denotes .
T19853 31918-32058 sentence denotes When compared to the B6 mice, the A/J mice and the three strains with elevated rebleeding time had variable Plg, PAI-1, and α2-antiplasmin.
T19854 31919-31923 WRB denotes When
T19855 31924-31932 VBN denotes compared
T19857 31933-31935 IN denotes to
T19858 31936-31939 DT denotes the
T19860 31940-31942 NN denotes B6
T19859 31943-31947 NNS denotes mice
T19861 31947-31949 , denotes ,
T19862 31949-31952 DT denotes the
T19864 31953-31954 NN denotes A
T19866 31954-31955 HYPH denotes /
T19865 31955-31956 NN denotes J
T19863 31957-31961 NNS denotes mice
T19867 31962-31965 CC denotes and
T19868 31966-31969 DT denotes the
T19870 31970-31975 CD denotes three
T19869 31976-31983 NNS denotes strains
T19871 31984-31988 IN denotes with
T19872 31989-31997 JJ denotes elevated
T19874 31998-32008 NN denotes rebleeding
T19873 32009-32013 NN denotes time
T19856 32014-32017 VBD denotes had
T19875 32018-32026 JJ denotes variable
T19876 32027-32030 NN denotes Plg
T19877 32030-32032 , denotes ,
T19878 32032-32035 NN denotes PAI
T19879 32035-32036 HYPH denotes -
T19880 32036-32037 CD denotes 1
T19881 32037-32039 , denotes ,
T19882 32039-32042 CC denotes and
T19883 32043-32045 NN denotes α2
T19885 32045-32046 HYPH denotes -
T19884 32046-32057 NN denotes antiplasmin
T19886 32057-32058 . denotes .
T19887 32058-32143 sentence denotes Two allelic forms of the mouse Plg gene have been reported for B6 and A/J mice [40].
T19888 32059-32062 CD denotes Two
T19890 32063-32070 JJ denotes allelic
T19889 32071-32076 NNS denotes forms
T19892 32077-32079 IN denotes of
T19893 32080-32083 DT denotes the
T19895 32084-32089 NN denotes mouse
T19896 32090-32093 NN denotes Plg
T19894 32094-32098 NN denotes gene
T19897 32099-32103 VBP denotes have
T19898 32104-32108 VBN denotes been
T19891 32109-32117 VBN denotes reported
T19899 32118-32121 IN denotes for
T19900 32122-32124 NN denotes B6
T19902 32125-32128 CC denotes and
T19903 32129-32130 NN denotes A
T19905 32130-32131 HYPH denotes /
T19904 32131-32132 NN denotes J
T19901 32133-32137 NNS denotes mice
T19906 32138-32139 -LRB- denotes [
T19907 32139-32141 CD denotes 40
T19908 32141-32142 -RRB- denotes ]
T19909 32142-32143 . denotes .
T19910 32143-32208 sentence denotes Plg concentration was increased in A/J mice compared to B6 mice.
T19911 32144-32147 NN denotes Plg
T19912 32148-32161 NN denotes concentration
T19914 32162-32165 VBD denotes was
T19913 32166-32175 VBN denotes increased
T19915 32176-32178 IN denotes in
T19916 32179-32180 NN denotes A
T19918 32180-32181 HYPH denotes /
T19917 32181-32182 NN denotes J
T19919 32183-32187 NNS denotes mice
T19920 32188-32196 VBN denotes compared
T19921 32197-32199 IN denotes to
T19922 32200-32202 NN denotes B6
T19923 32203-32207 NNS denotes mice
T19924 32207-32208 . denotes .
T19925 32208-32321 sentence denotes Although we did not detect differences in Plg structure, this would not exclude possible functional differences.
T19926 32209-32217 IN denotes Although
T19928 32218-32220 PRP denotes we
T19929 32221-32224 VBD denotes did
T19930 32225-32228 RB denotes not
T19927 32229-32235 VB denotes detect
T19932 32236-32247 NNS denotes differences
T19933 32248-32250 IN denotes in
T19934 32251-32254 NN denotes Plg
T19935 32255-32264 NN denotes structure
T19936 32264-32266 , denotes ,
T19937 32266-32270 DT denotes this
T19938 32271-32276 MD denotes would
T19939 32277-32280 RB denotes not
T19931 32281-32288 VB denotes exclude
T19940 32289-32297 JJ denotes possible
T19942 32298-32308 JJ denotes functional
T19941 32309-32320 NNS denotes differences
T19943 32320-32321 . denotes .
T19944 32321-32517 sentence denotes A congenic strain (specific for a homosomic region from A/J and the remaining Chr and background is from B6 mice) of A/J chromosome 17 that includes the Plg gene was tested in the bleeding assay.
T19945 32322-32323 DT denotes A
T19947 32324-32332 JJ denotes congenic
T19946 32333-32339 NN denotes strain
T19949 32340-32341 -LRB- denotes (
T19950 32341-32349 JJ denotes specific
T19951 32350-32353 IN denotes for
T19952 32354-32355 DT denotes a
T19954 32356-32365 JJ denotes homosomic
T19953 32366-32372 NN denotes region
T19955 32373-32377 IN denotes from
T19956 32378-32379 NN denotes A
T19958 32379-32380 HYPH denotes /
T19957 32380-32381 NN denotes J
T19959 32382-32385 CC denotes and
T19960 32386-32389 DT denotes the
T19962 32390-32399 VBG denotes remaining
T19961 32400-32403 NN denotes Chr
T19963 32404-32407 CC denotes and
T19965 32408-32418 NN denotes background
T19964 32419-32421 VBZ denotes is
T19966 32422-32426 IN denotes from
T19967 32427-32429 NN denotes B6
T19968 32430-32434 NNS denotes mice
T19969 32434-32435 -RRB- denotes )
T19970 32436-32438 IN denotes of
T19971 32439-32440 NN denotes A
T19973 32440-32441 HYPH denotes /
T19972 32441-32442 NN denotes J
T19974 32443-32453 NN denotes chromosome
T19975 32454-32456 CD denotes 17
T19976 32457-32461 WDT denotes that
T19977 32462-32470 VBZ denotes includes
T19978 32471-32474 DT denotes the
T19980 32475-32478 NN denotes Plg
T19979 32479-32483 NN denotes gene
T19981 32484-32487 VBD denotes was
T19948 32488-32494 VBN denotes tested
T19982 32495-32497 IN denotes in
T19983 32498-32501 DT denotes the
T19985 32502-32510 NN denotes bleeding
T19984 32511-32516 NN denotes assay
T19986 32516-32517 . denotes .
T19987 32517-32649 sentence denotes Values for bleeding and rebleeding in this congenic strain were similar to values from B6 mice, indicating that the QTL is not Plg.
T19988 32518-32524 NNS denotes Values
T19990 32525-32528 IN denotes for
T19991 32529-32537 NN denotes bleeding
T19992 32538-32541 CC denotes and
T19993 32542-32552 NN denotes rebleeding
T19994 32553-32555 IN denotes in
T19995 32556-32560 DT denotes this
T19997 32561-32569 JJ denotes congenic
T19996 32570-32576 NN denotes strain
T19989 32577-32581 VBD denotes were
T19998 32582-32589 JJ denotes similar
T19999 32590-32592 IN denotes to
T20000 32593-32599 NNS denotes values
T20001 32600-32604 IN denotes from
T20002 32605-32607 NN denotes B6
T20003 32608-32612 NNS denotes mice
T20004 32612-32614 , denotes ,
T20005 32614-32624 VBG denotes indicating
T20006 32625-32629 IN denotes that
T20008 32630-32633 DT denotes the
T20009 32634-32637 NN denotes QTL
T20007 32638-32640 VBZ denotes is
T20010 32641-32644 RB denotes not
T20011 32645-32648 NN denotes Plg
T20012 32648-32649 . denotes .
T20013 32649-32764 sentence denotes There are genes for other proteases and matrix proteins that reside on chromosome 17 in addition to unknown genes.
T20014 32650-32655 EX denotes There
T20015 32656-32659 VBP denotes are
T20016 32660-32665 NNS denotes genes
T20017 32666-32669 IN denotes for
T20018 32670-32675 JJ denotes other
T20019 32676-32685 NNS denotes proteases
T20020 32686-32689 CC denotes and
T20021 32690-32696 NN denotes matrix
T20022 32697-32705 NN denotes proteins
T20023 32706-32710 WDT denotes that
T20024 32711-32717 VBP denotes reside
T20025 32718-32720 IN denotes on
T20026 32721-32731 NN denotes chromosome
T20027 32732-32734 CD denotes 17
T20028 32735-32737 IN denotes in
T20029 32738-32746 NN denotes addition
T20030 32747-32749 IN denotes to
T20031 32750-32757 JJ denotes unknown
T20032 32758-32763 NNS denotes genes
T20033 32763-32764 . denotes .
T20034 32764-32961 sentence denotes DNA base pair sequence data for the PAI-1 gene or the α2-antiplasmin gene in B6 and A/J mice have reported no differences [51], but regulatory genes upstream of the coding region may be important.
T20035 32765-32768 NN denotes DNA
T20037 32769-32773 NN denotes base
T20039 32774-32778 NN denotes pair
T20038 32779-32787 NN denotes sequence
T20036 32788-32792 NNS denotes data
T20041 32793-32796 IN denotes for
T20042 32797-32800 DT denotes the
T20044 32801-32804 NN denotes PAI
T20045 32804-32805 HYPH denotes -
T20046 32805-32806 CD denotes 1
T20043 32807-32811 NN denotes gene
T20047 32812-32814 CC denotes or
T20048 32815-32818 DT denotes the
T20050 32819-32821 NN denotes α2
T20052 32821-32822 HYPH denotes -
T20051 32822-32833 NN denotes antiplasmin
T20049 32834-32838 NN denotes gene
T20053 32839-32841 IN denotes in
T20054 32842-32844 NN denotes B6
T20056 32845-32848 CC denotes and
T20057 32849-32850 NN denotes A
T20059 32850-32851 HYPH denotes /
T20058 32851-32852 NN denotes J
T20055 32853-32857 NNS denotes mice
T20060 32858-32862 VBP denotes have
T20040 32863-32871 VBN denotes reported
T20061 32872-32874 DT denotes no
T20062 32875-32886 NNS denotes differences
T20063 32887-32888 -LRB- denotes [
T20064 32888-32890 CD denotes 51
T20065 32890-32891 -RRB- denotes ]
T20066 32891-32893 , denotes ,
T20067 32893-32896 CC denotes but
T20068 32897-32907 JJ denotes regulatory
T20069 32908-32913 NNS denotes genes
T20071 32914-32922 RB denotes upstream
T20072 32923-32925 IN denotes of
T20073 32926-32929 DT denotes the
T20075 32930-32936 VBG denotes coding
T20074 32937-32943 NN denotes region
T20076 32944-32947 MD denotes may
T20070 32948-32950 VB denotes be
T20077 32951-32960 JJ denotes important
T20078 32960-32961 . denotes .
T20079 32961-33079 sentence denotes Our results suggest that novel or unknown genes may interact with the Plg system components to modify their function.
T20080 32962-32965 PRP$ denotes Our
T20081 32966-32973 NNS denotes results
T20082 32974-32981 VBP denotes suggest
T20083 32982-32986 IN denotes that
T20085 32987-32992 JJ denotes novel
T20087 32993-32995 CC denotes or
T20088 32996-33003 JJ denotes unknown
T20086 33004-33009 NNS denotes genes
T20089 33010-33013 MD denotes may
T20084 33014-33022 VB denotes interact
T20090 33023-33027 IN denotes with
T20091 33028-33031 DT denotes the
T20093 33032-33035 NN denotes Plg
T20094 33036-33042 NN denotes system
T20092 33043-33053 NNS denotes components
T20095 33054-33056 TO denotes to
T20096 33057-33063 VB denotes modify
T20097 33064-33069 PRP$ denotes their
T20098 33070-33078 NN denotes function
T20099 33078-33079 . denotes .
T20100 33079-33346 sentence denotes In summary, this study reports marked differences in two inbred strains of mice, B6 and A/J, in arterial thrombosis formation in a FeCl3 vascular injury model, rebleeding time in a tail bleeding assay, plasminogen function, and tissue and vessel collagen deposition.
T20101 33080-33082 IN denotes In
T20103 33083-33090 NN denotes summary
T20104 33090-33092 , denotes ,
T20105 33092-33096 DT denotes this
T20106 33097-33102 NN denotes study
T20102 33103-33110 VBZ denotes reports
T20107 33111-33117 JJ denotes marked
T20108 33118-33129 NNS denotes differences
T20109 33130-33132 IN denotes in
T20110 33133-33136 CD denotes two
T20112 33137-33143 JJ denotes inbred
T20111 33144-33151 NNS denotes strains
T20113 33152-33154 IN denotes of
T20114 33155-33159 NNS denotes mice
T20115 33159-33161 , denotes ,
T20116 33161-33163 NN denotes B6
T20117 33164-33167 CC denotes and
T20118 33168-33169 NN denotes A
T20120 33169-33170 HYPH denotes /
T20119 33170-33171 NN denotes J
T20121 33171-33173 , denotes ,
T20122 33173-33175 IN denotes in
T20123 33176-33184 JJ denotes arterial
T20124 33185-33195 NN denotes thrombosis
T20125 33196-33205 NN denotes formation
T20126 33206-33208 IN denotes in
T20127 33209-33210 DT denotes a
T20129 33211-33216 NN denotes FeCl3
T20130 33217-33225 JJ denotes vascular
T20131 33226-33232 NN denotes injury
T20128 33233-33238 NN denotes model
T20132 33238-33240 , denotes ,
T20133 33240-33250 NN denotes rebleeding
T20134 33251-33255 NN denotes time
T20135 33256-33258 IN denotes in
T20136 33259-33260 DT denotes a
T20138 33261-33265 NN denotes tail
T20139 33266-33274 NN denotes bleeding
T20137 33275-33280 NN denotes assay
T20140 33280-33282 , denotes ,
T20141 33282-33293 NN denotes plasminogen
T20142 33294-33302 NN denotes function
T20143 33302-33304 , denotes ,
T20144 33304-33307 CC denotes and
T20145 33308-33314 NN denotes tissue
T20147 33315-33318 CC denotes and
T20148 33319-33325 NN denotes vessel
T20149 33326-33334 NN denotes collagen
T20146 33335-33345 NN denotes deposition
T20150 33345-33346 . denotes .
T20151 33346-33428 sentence denotes Three chromosomes from A/J mice were identified that had QTL for rebleeding time.
T20152 33347-33352 CD denotes Three
T20153 33353-33364 NNS denotes chromosomes
T20155 33365-33369 IN denotes from
T20156 33370-33371 NN denotes A
T20158 33371-33372 HYPH denotes /
T20157 33372-33373 NN denotes J
T20159 33374-33378 NNS denotes mice
T20160 33379-33383 VBD denotes were
T20154 33384-33394 VBN denotes identified
T20161 33395-33399 WDT denotes that
T20162 33400-33403 VBD denotes had
T20163 33404-33407 NN denotes QTL
T20164 33408-33411 IN denotes for
T20165 33412-33422 NN denotes rebleeding
T20166 33423-33427 NN denotes time
T20167 33427-33428 . denotes .
T20168 33428-33524 sentence denotes The genes may interact with components in the Plg network and modulate arterial occlusion time.
T20169 33429-33432 DT denotes The
T20170 33433-33438 NNS denotes genes
T20172 33439-33442 MD denotes may
T20171 33443-33451 VB denotes interact
T20173 33452-33456 IN denotes with
T20174 33457-33467 NNS denotes components
T20175 33468-33470 IN denotes in
T20176 33471-33474 DT denotes the
T20178 33475-33478 NN denotes Plg
T20177 33479-33486 NN denotes network
T20179 33487-33490 CC denotes and
T20180 33491-33499 VB denotes modulate
T20181 33500-33508 JJ denotes arterial
T20182 33509-33518 NN denotes occlusion
T20183 33519-33523 NN denotes time
T20184 33523-33524 . denotes .
T20400 33537-33540 DT denotes The
T20402 33541-33547 JJ denotes marked
T20403 33548-33559 JJ denotes independent
T20401 33560-33571 NNS denotes differences
T20405 33572-33584 VBN denotes demonstrated
T20406 33585-33587 IN denotes in
T20407 33588-33591 DT denotes the
T20409 33592-33594 NN denotes B6
T20410 33595-33598 CC denotes and
T20411 33599-33600 NN denotes A
T20413 33600-33601 HYPH denotes /
T20412 33601-33602 NN denotes J
T20408 33603-33607 NNS denotes mice
T20414 33608-33611 MD denotes can
T20415 33612-33614 VB denotes be
T20404 33615-33624 VBN denotes exploited
T20416 33625-33627 TO denotes to
T20417 33628-33636 VB denotes identify
T20418 33637-33644 JJ denotes genetic
T20419 33645-33657 NNS denotes determinants
T20420 33658-33660 IN denotes of
T20421 33661-33671 NN denotes thrombosis
T20422 33672-33675 CC denotes and
T20423 33676-33687 NN denotes haemostasis
T20424 33687-33688 . denotes .
T20425 33688-33908 sentence denotes Our results of the CSS screening suggest that novel or unknown genes can be used to identify the genes responsible for the traits related to arterial thrombosis, tail bleeding/rebleeding and vessel extracellular matrix.
T20426 33689-33692 PRP$ denotes Our
T20427 33693-33700 NNS denotes results
T20429 33701-33703 IN denotes of
T20430 33704-33707 DT denotes the
T20432 33708-33711 NN denotes CSS
T20431 33712-33721 NN denotes screening
T20428 33722-33729 VBP denotes suggest
T20433 33730-33734 IN denotes that
T20435 33735-33740 JJ denotes novel
T20437 33741-33743 CC denotes or
T20438 33744-33751 JJ denotes unknown
T20436 33752-33757 NNS denotes genes
T20439 33758-33761 MD denotes can
T20440 33762-33764 VB denotes be
T20434 33765-33769 VBN denotes used
T20441 33770-33772 TO denotes to
T20442 33773-33781 VB denotes identify
T20443 33782-33785 DT denotes the
T20444 33786-33791 NNS denotes genes
T20445 33792-33803 JJ denotes responsible
T20446 33804-33807 IN denotes for
T20447 33808-33811 DT denotes the
T20448 33812-33818 NNS denotes traits
T20449 33819-33826 VBN denotes related
T20450 33827-33829 IN denotes to
T20451 33830-33838 JJ denotes arterial
T20452 33839-33849 NN denotes thrombosis
T20453 33849-33851 , denotes ,
T20454 33851-33855 NN denotes tail
T20456 33856-33864 NN denotes bleeding
T20457 33864-33865 HYPH denotes /
T20455 33865-33875 NN denotes rebleeding
T20458 33876-33879 CC denotes and
T20459 33880-33886 NN denotes vessel
T20461 33887-33900 JJ denotes extracellular
T20460 33901-33907 NN denotes matrix
T20462 33907-33908 . denotes .
T20463 33908-34106 sentence denotes Identification of differences in the parent strains, such as those described in this study, and screening of the CSS is a first-step in the discovery of new genetic determinants of thrombotic risk.
T20464 33909-33923 NN denotes Identification
T20466 33924-33926 IN denotes of
T20467 33927-33938 NNS denotes differences
T20468 33939-33941 IN denotes in
T20469 33942-33945 DT denotes the
T20471 33946-33952 NN denotes parent
T20470 33953-33960 NNS denotes strains
T20472 33960-33962 , denotes ,
T20473 33962-33966 JJ denotes such
T20474 33967-33969 IN denotes as
T20475 33970-33975 DT denotes those
T20476 33976-33985 VBN denotes described
T20477 33986-33988 IN denotes in
T20478 33989-33993 DT denotes this
T20479 33994-33999 NN denotes study
T20480 33999-34001 , denotes ,
T20481 34001-34004 CC denotes and
T20482 34005-34014 NN denotes screening
T20483 34015-34017 IN denotes of
T20484 34018-34021 DT denotes the
T20485 34022-34025 NN denotes CSS
T20465 34026-34028 VBZ denotes is
T20486 34029-34030 DT denotes a
T20488 34031-34036 JJ denotes first
T20489 34036-34037 HYPH denotes -
T20487 34037-34041 NN denotes step
T20490 34042-34044 IN denotes in
T20491 34045-34048 DT denotes the
T20492 34049-34058 NN denotes discovery
T20493 34059-34061 IN denotes of
T20494 34062-34065 JJ denotes new
T20496 34066-34073 JJ denotes genetic
T20495 34074-34086 NNS denotes determinants
T20497 34087-34089 IN denotes of
T20498 34090-34100 JJ denotes thrombotic
T20499 34101-34105 NN denotes risk
T20500 34105-34106 . denotes .
T20522 35216-35219 DT denotes The
T20524 35220-35235 JJ denotes pre-publication
T20523 35236-35243 NN denotes history
T20526 35244-35247 IN denotes for
T20527 35248-35252 DT denotes this
T20528 35253-35258 NN denotes paper
T20529 35259-35262 MD denotes can
T20530 35263-35265 VB denotes be
T20525 35266-35274 VBN denotes accessed
T20531 35275-35279 RB denotes here
T20532 35279-35280 : denotes :
R1000 T3708 T3707 prep of,presence
R1001 T3709 T3710 amod other,QTL
R1002 T3738 T3739 compound B6,19
R1003 T3710 T3708 pobj QTL,of
R1004 T3711 T3698 punct .,is
R1005 T3739 T3735 appos 19,panel
R1006 T3713 T3714 prep In,simplify
R1007 T3740 T3739 compound Chr1,19
R1008 T3715 T3713 pobj addition,In
R1009 T3716 T3714 punct ", ",simplify
R1010 T3717 T3718 amod initial,screens
R1011 T3718 T3714 nsubj screens,simplify
R1012 T3741 T3739 punct -,19
R1013 T3719 T3718 prep with,screens
R1014 T3720 T3721 det the,CSS
R1015 T3742 T3739 punct ", ",19
R1016 T3721 T3719 pobj CSS,with
R1017 T3722 T3723 det the,mapping
R1018 T3743 T3739 appos X,19
R1019 T3723 T3714 dobj mapping,simplify
R1020 T3744 T3739 punct ", ",19
R1021 T3724 T3723 advmod fine,mapping
R1022 T3725 T3723 punct -,mapping
R1023 T3745 T3746 compound YA,J
R1024 T3726 T3723 prep of,mapping
R1025 T3727 T3726 pobj QTL,of
R1026 T3746 T3739 appos J,19
R1027 T3747 T3746 punct /,J
R1028 T3748 T3732 punct ", ",reported
R1029 T3834 T3832 conj fibrinolysis,coagulation
R1030 T3749 T3732 aux have,reported
R1031 T3835 T3801 punct .,was
R1032 T3750 T3732 auxpass been,reported
R1033 T3837 T3838 det The,results
R1034 T3838 T3839 nsubj results,indicate
R1035 T3751 T3732 prep for,reported
R1036 T3840 T3838 prep of,results
R1037 T3841 T3842 det this,study
R1038 T3752 T3751 pobj behavior,for
R1039 T3842 T3840 pobj study,of
R1040 T3843 T3844 mark that,have
R1041 T3844 T3839 ccomp have,indicate
R1042 T3753 T3754 punct [,12
R1043 T3845 T3846 det the,strains
R1044 T3846 T3844 nsubj strains,have
R1045 T3754 T3752 parataxis 12,behavior
R1046 T3847 T3846 nummod two,strains
R1047 T3848 T3846 amod inbred,strains
R1048 T3849 T3846 punct ", ",strains
R1049 T3755 T3754 punct ],12
R1050 T3850 T3851 nmod B6,mice
R1051 T3851 T3846 appos mice,strains
R1052 T3852 T3850 cc and,B6
R1053 T3756 T3752 punct ", ",behavior
R1054 T3853 T3854 compound A,J
R1055 T3854 T3850 conj J,B6
R1056 T3757 T3758 compound weight,gain
R1057 T3855 T3854 punct /,J
R1058 T3758 T3752 conj gain,behavior
R1059 T3856 T3844 punct ", ",have
R1060 T3857 T3858 amod diverse,phenotypes
R1061 T3858 T3844 dobj phenotypes,have
R1062 T3859 T3858 amod prothrombotic,phenotypes
R1063 T3759 T3760 punct [,13
R1064 T3860 T3858 punct ", ",phenotypes
R1065 T3861 T3858 amod unrelated,phenotypes
R1066 T3760 T3758 parataxis 13,gain
R1067 T3862 T3861 prep to,unrelated
R1068 T3863 T3862 pobj coagulation,to
R1069 T3864 T3863 cc or,coagulation
R1070 T3761 T3760 punct ],13
R1071 T3865 T3866 compound platelet,aggregation
R1072 T3866 T3863 conj aggregation,coagulation
R1073 T3867 T3839 punct .,indicate
R1074 T3762 T3758 punct ", ",gain
R1075 T3869 T3870 prep In,modified
R1076 T3763 T3758 conj sterols,gain
R1077 T3871 T3869 pobj addition,In
R1078 T3872 T3870 punct ", ",modified
R1079 T3764 T3765 punct [,13
R1080 T3873 T3870 prep in,modified
R1081 T3874 T3875 det the,CSS
R1082 T3875 T3873 pobj CSS,in
R1083 T3876 T3870 punct ", ",modified
R1084 T3877 T3870 nsubjpass expression,modified
R1085 T3878 T3877 prep of,expression
R1086 T3765 T3763 parataxis 13,sterols
R1087 T3879 T3880 det the,phenotypes
R1088 T3880 T3878 pobj phenotypes,of
R1089 T3881 T3882 compound A,J
R1090 T3766 T3765 punct ],13
R1091 T3882 T3880 compound J,phenotypes
R1092 T3883 T3882 punct /,J
R1093 T3767 T3763 punct ", ",sterols
R1094 T3884 T3880 punct ", ",phenotypes
R1095 T3885 T3886 compound rebleeding,time
R1096 T3886 T3880 conj time,phenotypes
R1097 T3887 T3886 cc and,time
R1098 T3768 T3763 cc and,sterols
R1099 T3888 T3889 amod arterial,occlusion
R1100 T3889 T3886 conj occlusion,time
R1101 T3769 T3770 compound plasma,levels
R1102 T3890 T3870 punct ", ",modified
R1103 T3891 T3870 auxpass was,modified
R1104 T3892 T3870 prep in,modified
R1105 T3770 T3763 conj levels,sterols
R1106 T3771 T3772 compound amino,acids
R1107 T3893 T3894 det the,background
R1108 T3772 T3770 compound acids,levels
R1109 T3894 T3892 pobj background,in
R1110 T3895 T3894 compound B6,background
R1111 T3773 T3774 punct [,14
R1112 T3896 T3870 punct ", ",modified
R1113 T3897 T3870 cc and,modified
R1114 T3774 T3770 parataxis 14,levels
R1115 T3898 T3870 conj suggested,modified
R1116 T3899 T3900 mark that,occurred
R1117 T3900 T3898 ccomp occurred,suggested
R1118 T3775 T3774 nummod 13,14
R1119 T3901 T3900 nsubj interactions,occurred
R1120 T3902 T3900 prep among,occurred
R1121 T3776 T3774 punct ",",14
R1122 T3903 T3904 det the,QTL
R1123 T3904 T3902 pobj QTL,among
R1124 T3905 T3906 compound A,J
R1125 T3777 T3774 punct ],14
R1126 T3906 T3904 compound J,QTL
R1127 T3907 T3906 punct /,J
R1128 T3778 T3732 punct ", ",reported
R1129 T3908 T3870 punct .,modified
R1130 T3910 T3911 advmod Thus,be
R1131 T3779 T3732 cc and,reported
R1132 T3912 T3911 punct ", ",be
R1133 T3913 T3911 nsubj it,be
R1134 T3914 T3911 aux should,be
R1135 T3915 T3911 acomp possible,be
R1136 T3780 T3781 aux have,identified
R1137 T3916 T3917 aux to,identify
R1138 T3917 T3911 xcomp identify,be
R1139 T3918 T3919 amod independent,determinants
R1140 T3919 T3917 dobj determinants,identify
R1141 T3781 T3732 conj identified,reported
R1142 T3920 T3919 amod genetic,determinants
R1143 T3921 T3919 prep of,determinants
R1144 T3922 T3921 pobj susceptibility,of
R1145 T3782 T3783 amod many,more
R1146 T3923 T3922 prep to,susceptibility
R1147 T3924 T3925 amod pathological,haemostasis
R1148 T3783 T3784 amod more,QTL
R1149 T3925 T3923 pobj haemostasis,to
R1150 T3926 T3925 cc and,haemostasis
R1151 T3927 T3925 conj thrombosis,haemostasis
R1152 T3784 T3781 dobj QTL,identified
R1153 T3928 T3911 punct .,be
R1154 T3785 T3784 prep than,QTL
R1155 T3786 T3785 pobj studies,than
R1156 T3787 T3786 prep of,studies
R1157 T3788 T3789 det the,traits
R1158 T3789 T3787 pobj traits,of
R1159 T3790 T3789 amod same,traits
R1160 T3791 T3786 acl using,studies
R1161 T3792 T3793 det a,scan
R1162 T3793 T3791 dobj scan,using
R1163 T3794 T3795 npadvmod genome,wide
R1164 T3795 T3793 amod wide,scan
R1165 T3796 T3795 punct -,wide
R1166 T3797 T3732 punct .,reported
R1167 T3799 T3800 det The,purpose
R1168 T3800 T3801 nsubj purpose,was
R1169 T3802 T3800 prep of,purpose
R1170 T3803 T3804 det this,study
R1171 T3804 T3802 pobj study,of
R1172 T3805 T3806 aux to,evaluate
R1173 T3806 T3801 xcomp evaluate,was
R1174 T3807 T3808 det the,strains
R1175 T3808 T3806 dobj strains,evaluate
R1176 T3809 T3808 nummod two,strains
R1177 T3810 T3808 amod inbred,strains
R1178 T3811 T3808 prep of,strains
R1179 T3812 T3811 pobj mice,of
R1180 T3813 T3806 prep for,evaluate
R1181 T3814 T3815 amod prothrombotic,risk
R1182 T3815 T3813 pobj risk,for
R1183 T3816 T3806 punct ", ",evaluate
R1184 T3817 T3806 advcl utilizing,evaluate
R1185 T3818 T3819 det a,model
R1186 T3819 T3817 dobj model,utilizing
R1187 T3820 T3821 amod ferric,chloride
R1188 T3821 T3819 nmod chloride,model
R1189 T3822 T3823 amod vascular,injury
R1190 T3823 T3819 compound injury,model
R1191 T3824 T3819 punct ", ",model
R1192 T3825 T3826 compound tail,bleeding
R1193 T3826 T3827 compound bleeding,assay
R1194 T3827 T3819 conj assay,model
R1195 T3828 T3827 punct ", ",assay
R1196 T3829 T3827 cc and,assay
R1197 T3830 T3827 conj measures,assay
R1198 T3831 T3830 prep of,measures
R1199 T3832 T3831 pobj coagulation,of
R1200 T3833 T3832 cc and,coagulation
R1205 T4566 T4567 det The,strains
R1206 T4567 T4569 nsubjpass strains,obtained
R1207 T4568 T4567 amod inbred,strains
R1208 T4570 T4567 punct ", ",strains
R1209 T4571 T4567 conj B6,strains
R1210 T4572 T4573 punct (,#
R1211 T4573 T4571 parataxis #,B6
R1212 T4574 T4573 nummod 000664,#
R1213 T4575 T4573 punct ),#
R1214 T4576 T4571 punct ", ",B6
R1215 T4577 T4571 conj Lepob,B6
R1216 T4578 T4579 punct (,#
R1217 T4579 T4577 parataxis #,Lepob
R1218 T4580 T4579 nummod 000632,#
R1219 T4581 T4579 punct ),#
R1220 T4582 T4577 punct ", ",Lepob
R1221 T4583 T4584 compound A,J
R1222 T4584 T4577 conj J,Lepob
R1223 T4585 T4584 punct /,J
R1224 T4586 T4587 punct (,#
R1225 T4587 T4584 parataxis #,J
R1226 T4588 T4587 nummod 000646,#
R1227 T4589 T4587 punct ),#
R1228 T4590 T4584 cc and,J
R1229 T4591 T4592 npadvmod gene,targeted
R1230 T4592 T4594 amod targeted,mice
R1231 T4593 T4592 punct -,targeted
R1232 T4594 T4584 conj mice,J
R1233 T4595 T4596 nmod plasminogen,inhibitor
R1234 T4596 T4601 npadvmod inhibitor,deficient
R1235 T4597 T4595 punct (,plasminogen
R1236 T4598 T4595 appos Plg,plasminogen
R1237 T4599 T4596 punct ),inhibitor
R1238 T4600 T4596 compound activator,inhibitor
R1239 T4601 T4594 amod deficient,mice
R1240 T4602 T4594 punct (,mice
R1241 T4603 T4604 nmod PAI,mice
R1242 T4604 T4594 appos mice,mice
R1243 T4605 T4603 punct -,PAI
R1244 T4606 T4603 nummod 1,PAI
R1245 T4607 T4603 punct -,PAI
R1246 T4608 T4603 punct /,PAI
R1247 T4609 T4603 punct -,PAI
R1248 T4610 T4603 punct ),PAI
R1249 T4611 T4612 punct (,#
R1250 T4612 T4603 parataxis #,PAI
R1251 T4613 T4612 nummod 002507,#
R1252 T4614 T4612 punct ),#
R1253 T4615 T4616 punct [,15
R1254 T4616 T4603 parataxis 15,PAI
R1255 T4617 T4616 punct ],15
R1256 T4618 T4594 prep in,mice
R1257 T4619 T4620 det a,background
R1258 T4620 T4618 pobj background,in
R1259 T4621 T4620 compound B6,background
R1260 T4622 T4569 auxpass were,obtained
R1261 T4623 T4569 prep from,obtained
R1262 T4624 T4625 compound Jackson,Laboratory
R1263 T4625 T4623 pobj Laboratory,from
R1264 T4626 T4625 punct (,Laboratory
R1265 T4627 T4628 compound Bar,Harbor
R1266 T4628 T4625 npadvmod Harbor,Laboratory
R1267 T4629 T4625 punct ", ",Laboratory
R1268 T4630 T4625 npadvmod Maine,Laboratory
R1269 T4631 T4569 punct ),obtained
R1270 T4632 T4569 prep at,obtained
R1271 T4633 T4634 nummod 6,wks
R1272 T4634 T4632 pobj wks,at
R1273 T4635 T4634 punct -,wks
R1274 T4636 T4634 prep of,wks
R1275 T4637 T4636 punct -,of
R1276 T4638 T4636 pobj age,of
R1277 T4639 T4569 punct .,obtained
R1278 T4641 T4642 det The,mice
R1279 T4642 T4647 nsubjpass mice,generated
R1280 T4643 T4642 nmod Plg,mice
R1281 T4644 T4643 punct -,Plg
R1282 T4645 T4643 punct /,Plg
R1283 T4646 T4643 punct -,Plg
R1284 T4648 T4647 auxpass were,generated
R1285 T4649 T4650 mark as,described
R1286 T4650 T4647 advcl described,generated
R1287 T4651 T4650 advmod previously,described
R1288 T4652 T4653 punct [,16
R1289 T4653 T4650 parataxis 16,described
R1290 T4654 T4653 punct ],16
R1291 T4655 T4647 cc and,generated
R1292 T4656 T4647 conj maintained,generated
R1293 T4657 T4656 prep in,maintained
R1294 T4658 T4659 det the,background
R1295 T4659 T4657 pobj background,in
R1296 T4660 T4659 compound B6,background
R1297 T4661 T4656 punct ", ",maintained
R1298 T4662 T4656 conj generated,maintained
R1299 T4663 T4662 prep by,generated
R1300 T4664 T4663 pcomp crossing,by
R1301 T4665 T4664 dobj mice,crossing
R1302 T4666 T4665 prep from,mice
R1303 T4667 T4668 det the,background
R1304 T4668 T4666 pobj background,from
R1305 T4669 T4668 amod original,background
R1306 T4670 T4668 amod mixed,background
R1307 T4671 T4668 punct (,background
R1308 T4672 T4668 nmod B6,background
R1309 T4673 T4672 punct :,B6
R1310 T4674 T4672 nummod 129,B6
R1311 T4675 T4668 punct ),background
R1312 T4676 T4664 prep for,crossing
R1313 T4677 T4678 nummod eight,generations
R1314 T4678 T4676 pobj generations,for
R1315 T4679 T4664 prep with,crossing
R1316 T4680 T4681 compound B6,mice
R1317 T4681 T4679 pobj mice,with
R1318 T4682 T4647 punct .,generated
R1319 T4684 T4685 det The,mice
R1320 T4685 T4690 nsubj mice,reproduce
R1321 T4686 T4685 nmod Plg,mice
R1322 T4687 T4686 punct -,Plg
R1323 T4688 T4686 punct /,Plg
R1324 T4689 T4686 punct -,Plg
R1325 T4691 T4690 aux do,reproduce
R1326 T4692 T4690 neg not,reproduce
R1327 T4693 T4690 advmod well,reproduce
R1328 T4694 T4690 cc and,reproduce
R1329 T4695 T4696 nmod Plg,pairs
R1330 T4696 T4698 nsubjpass pairs,used
R1331 T4697 T4696 amod heterozygous,pairs
R1332 T4698 T4690 conj used,reproduce
R1333 T4699 T4698 auxpass were,used
R1334 T4700 T4698 prep for,used
R1335 T4701 T4700 pobj breeding,for
R1336 T4702 T4698 punct .,used
R1337 T4704 T4705 nsubjpass Genotypes,determined
R1338 T4706 T4704 punct (,Genotypes
R1339 T4707 T4704 appos Plg,Genotypes
R1340 T4708 T4707 punct +,Plg
R1341 T4709 T4707 punct /,Plg
R1342 T4710 T4707 punct +,Plg
R1343 T4711 T4707 punct ", ",Plg
R1344 T4712 T4707 appos Plg,Plg
R1345 T4713 T4712 punct +,Plg
R1346 T4714 T4712 punct /,Plg
R1347 T4715 T4712 punct -,Plg
R1348 T4716 T4707 punct ", ",Plg
R1349 T4717 T4707 appos Plg,Plg
R1350 T4718 T4717 punct -,Plg
R1351 T4719 T4717 punct /,Plg
R1352 T4720 T4717 punct -,Plg
R1353 T4721 T4704 punct ),Genotypes
R1354 T4722 T4704 prep of,Genotypes
R1355 T4723 T4724 det the,offspring
R1356 T4724 T4722 pobj offspring,of
R1357 T4725 T4705 auxpass were,determined
R1358 T4726 T4705 prep by,determined
R1359 T4727 T4728 det a,assay
R1360 T4728 T4726 pobj assay,by
R1361 T4729 T4728 compound PCR,assay
R1362 T4730 T4728 prep at,assay
R1363 T4731 T4732 quantmod 3,4
R1364 T4732 T4734 nummod 4,weeks
R1365 T4733 T4732 punct –,4
R1366 T4734 T4730 pobj weeks,at
R1367 T4735 T4734 punct -,weeks
R1368 T4736 T4734 prep of,weeks
R1369 T4737 T4736 punct -,of
R1370 T4738 T4736 pobj age,of
R1371 T4739 T4728 prep from,assay
R1372 T4740 T4741 det an,punch
R1373 T4741 T4739 pobj punch,from
R1374 T4742 T4741 compound ear,punch
R1375 T4743 T4744 punct [,17
R1376 T4744 T4705 parataxis 17,determined
R1377 T4745 T4744 punct ],17
R1378 T4746 T4705 punct .,determined
R1379 T4748 T4749 compound Breeding,pairs
R1380 T4749 T4750 nsubjpass pairs,transferred
R1381 T4751 T4749 prep of,pairs
R1382 T4752 T4753 det the,mice
R1383 T4753 T4751 pobj mice,of
R1384 T4754 T4753 compound CSS,mice
R1385 T4755 T4750 auxpass were,transferred
R1386 T4756 T4750 prep from,transferred
R1387 T4757 T4758 compound Dr.,Nadeau
R1388 T4758 T4759 poss Nadeau,laboratory
R1389 T4759 T4756 pobj laboratory,from
R1390 T4760 T4758 case 's,Nadeau
R1391 T4761 T4750 punct .,transferred
R1392 T4763 T4764 det All,mice
R1393 T4764 T4765 nsubjpass mice,housed
R1394 T4766 T4765 auxpass were,housed
R1395 T4767 T4765 cc and,housed
R1396 T4768 T4765 conj bred,housed
R1397 T4769 T4768 prep in,bred
R1398 T4770 T4771 det the,Unit
R1399 T4771 T4769 pobj Unit,in
R1400 T4772 T4771 compound Biological,Unit
R1401 T4773 T4771 compound Resource,Unit
R1402 T4774 T4771 prep at,Unit
R1403 T4775 T4776 det the,Foundation
R1404 T4776 T4774 pobj Foundation,at
R1405 T4777 T4776 compound Cleveland,Foundation
R1406 T4778 T4776 compound Clinic,Foundation
R1407 T4779 T4776 punct (,Foundation
R1408 T4780 T4776 appos CCF,Foundation
R1409 T4781 T4765 punct ),housed
R1410 T4782 T4765 punct .,housed
R1411 T4784 T4785 nsubjpass Mice,housed
R1412 T4786 T4785 auxpass were,housed
R1413 T4787 T4785 prep in,housed
R1414 T4788 T4789 amod sterilized,cages
R1415 T4789 T4787 pobj cages,in
R1416 T4790 T4789 compound isolator,cages
R1417 T4791 T4785 punct ", ",housed
R1418 T4792 T4785 dep maintained,housed
R1419 T4793 T4792 prep on,maintained
R1420 T4794 T4795 det a,cycle
R1421 T4795 T4793 pobj cycle,on
R1422 T4796 T4797 nummod 14,hr
R1423 T4797 T4798 nmod hr,light
R1424 T4798 T4795 nmod light,cycle
R1425 T4799 T4798 punct /,light
R1426 T4800 T4801 nummod 10,hr
R1427 T4801 T4802 compound hr,dark
R1428 T4802 T4798 appos dark,light
R1429 T4803 T4785 punct ", ",housed
R1430 T4804 T4785 cc and,housed
R1431 T4805 T4806 auxpass were,provided
R1432 T4806 T4785 conj provided,housed
R1433 T4807 T4808 amod sterilized,food
R1434 T4808 T4806 dobj food,provided
R1435 T4809 T4808 cc and,food
R1436 T4810 T4808 conj water,food
R1437 T4811 T4812 advmod ad,libitum
R1438 T4812 T4806 advmod libitum,provided
R1439 T4813 T4785 punct .,housed
R1440 T4815 T4816 nsubjpass Mice,fed
R1441 T4817 T4816 auxpass were,fed
R1442 T4818 T4819 det a,diet
R1443 T4819 T4816 dobj diet,fed
R1444 T4820 T4819 amod standard,diet
R1445 T4821 T4819 amod autoclavable,diet
R1446 T4822 T4819 compound laboratory,diet
R1447 T4823 T4819 acl consisting,diet
R1448 T4824 T4823 prep of,consisting
R1449 T4825 T4824 punct : ,of
R1450 T4826 T4827 nummod 23,%
R1451 T4827 T4828 compound %,protein
R1452 T4828 T4824 pobj protein,of
R1453 T4829 T4828 punct ", ",protein
R1454 T4830 T4831 nummod 4.5,%
R1455 T4831 T4832 compound %,fat
R1456 T4832 T4828 appos fat,protein
R1457 T4833 T4828 punct ", ",protein
R1458 T4834 T4835 nummod 6,%
R1459 T4835 T4836 compound %,fiber
R1460 T4836 T4828 appos fiber,protein
R1461 T4837 T4828 punct ", ",protein
R1462 T4838 T4839 punct (,Purina
R1463 T4839 T4828 parataxis Purina,protein
R1464 T4840 T4839 punct ", ",Purina
R1465 T4841 T4842 compound St.,Louis
R1466 T4842 T4839 npadvmod Louis,Purina
R1467 T4843 T4839 punct ", ",Purina
R1468 T4844 T4839 npadvmod MO,Purina
R1469 T4845 T4839 punct ),Purina
R1470 T4846 T4816 punct ", ",fed
R1471 T4847 T4816 cc and,fed
R1472 T4848 T4816 conj tested,fed
R1473 T4849 T4848 prep between,tested
R1474 T4850 T4851 nummod 7,wks
R1475 T4851 T4849 pobj wks,between
R1476 T4852 T4850 cc and,7
R1477 T4853 T4850 conj 9,7
R1478 T4854 T4851 punct -,wks
R1479 T4855 T4851 prep of,wks
R1480 T4856 T4855 punct -,of
R1481 T4857 T4855 pobj age,of
R1482 T4858 T4816 punct .,fed
R1483 T4860 T4861 det All,experiments
R1484 T4861 T4863 nsubjpass experiments,performed
R1485 T4862 T4861 compound animal,experiments
R1486 T4864 T4863 auxpass were,performed
R1487 T4865 T4863 prep in,performed
R1488 T4866 T4865 pobj accordance,in
R1489 T4867 T4866 prep with,accordance
R1490 T4868 T4869 det a,protocol
R1491 T4869 T4867 pobj protocol,with
R1492 T4870 T4869 acl approved,protocol
R1493 T4871 T4870 agent by,approved
R1494 T4872 T4873 det the,Committee
R1495 T4873 T4871 pobj Committee,by
R1496 T4874 T4873 nmod Institutional,Committee
R1497 T4875 T4876 nmod Animal,Care
R1498 T4876 T4873 nmod Care,Committee
R1499 T4877 T4876 cc and,Care
R1500 T4878 T4879 compound Research,Advisory
R1501 T4879 T4876 conj Advisory,Care
R1502 T4880 T4873 prep at,Committee
R1503 T4881 T4880 pobj CCF,at
R1504 T4882 T4863 punct .,performed
R1505 T5305 T5306 amod Vascular,injury
R1506 T5308 T5309 aux To,induce
R1507 T5309 T5310 advcl induce,employed
R1508 T5311 T5312 compound thrombosis,formation
R1509 T5312 T5309 dobj formation,induce
R1510 T5313 T5309 prep in,induce
R1511 T5314 T5315 det the,artery
R1512 T5315 T5313 pobj artery,in
R1513 T5316 T5315 compound carotid,artery
R1514 T5317 T5310 punct ", ",employed
R1515 T5318 T5319 det a,model
R1516 T5319 T5310 nsubjpass model,employed
R1517 T5320 T5321 amod ferric,chloride
R1518 T5321 T5319 nmod chloride,model
R1519 T5322 T5321 punct (,chloride
R1520 T5323 T5321 appos FeCl3,chloride
R1521 T5324 T5319 punct ),model
R1522 T5325 T5319 prep of,model
R1523 T5326 T5327 compound vessel,injury
R1524 T5327 T5325 pobj injury,of
R1525 T5328 T5329 punct [,19
R1526 T5329 T5319 parataxis 19,model
R1527 T5330 T5329 nummod 18,19
R1528 T5331 T5329 punct ",",19
R1529 T5332 T5329 punct ],19
R1530 T5333 T5310 auxpass was,employed
R1531 T5334 T5310 punct .,employed
R1532 T5336 T5337 nsubjpass Mice,anesthetized
R1533 T5338 T5337 auxpass were,anesthetized
R1534 T5339 T5337 prep with,anesthetized
R1535 T5340 T5341 compound ketamine,xylazine
R1536 T5341 T5339 pobj xylazine,with
R1537 T5342 T5341 punct /,xylazine
R1538 T5343 T5344 punct (,mg
R1539 T5344 T5341 parataxis mg,xylazine
R1540 T5345 T5346 nummod 80,mg
R1541 T5346 T5344 dep mg,mg
R1542 T5347 T5348 punct /,kg
R1543 T5348 T5346 prep kg,mg
R1544 T5349 T5344 punct ", ",mg
R1545 T5350 T5344 nummod 5,mg
R1546 T5351 T5352 punct /,kg
R1547 T5352 T5344 prep kg,mg
R1548 T5353 T5344 punct ),mg
R1549 T5354 T5337 punct ", ",anesthetized
R1550 T5355 T5356 det a,incision
R1551 T5356 T5359 nsubjpass incision,made
R1552 T5357 T5356 nmod midline,incision
R1553 T5358 T5356 amod cervical,incision
R1554 T5359 T5337 conj made,anesthetized
R1555 T5360 T5359 auxpass was,made
R1556 T5361 T5359 cc and,made
R1557 T5362 T5363 det the,artery
R1558 T5363 T5367 nsubj artery,isolated
R1559 T5364 T5363 amod left,artery
R1560 T5365 T5363 amod common,artery
R1561 T5366 T5363 amod carotid,artery
R1562 T5367 T5359 conj isolated,made
R1563 T5368 T5367 prep by,isolated
R1564 T5369 T5370 amod blunt,dissection
R1565 T5370 T5368 pobj dissection,by
R1566 T5371 T5367 punct .,isolated
R1567 T5373 T5374 det The,probe
R1568 T5374 T5376 nsubjpass probe,placed
R1569 T5375 T5374 compound flow,probe
R1570 T5377 T5378 punct (,0.5PSB
R1571 T5378 T5374 parataxis 0.5PSB,probe
R1572 T5379 T5380 compound Transonic,Systems
R1573 T5380 T5378 dep Systems,0.5PSB
R1574 T5381 T5378 punct ", ",0.5PSB
R1575 T5382 T5378 compound model,0.5PSB
R1576 T5383 T5378 punct ),0.5PSB
R1577 T5384 T5376 auxpass was,placed
R1578 T5385 T5376 prep under,placed
R1579 T5386 T5387 det the,artery
R1580 T5387 T5385 pobj artery,under
R1581 T5388 T5376 cc and,placed
R1582 T5389 T5390 advmod when,reached
R1583 T5390 T5395 advcl reached,applied
R1584 T5391 T5392 det a,baseline
R1585 T5392 T5390 nsubjpass baseline,reached
R1586 T5393 T5392 amod stable,baseline
R1587 T5394 T5390 auxpass was,reached
R1588 T5395 T5376 conj applied,placed
R1589 T5396 T5395 punct ", ",applied
R1590 T5397 T5398 det a,strip
R1591 T5398 T5395 nsubjpass strip,applied
R1592 T5399 T5400 nummod 0.5,2
R1593 T5400 T5402 nummod 2,mm
R1594 T5401 T5400 punct ×,2
R1595 T5402 T5398 compound mm,strip
R1596 T5403 T5398 prep of,strip
R1597 T5404 T5405 compound filter,paper
R1598 T5405 T5403 pobj paper,of
R1599 T5406 T5398 acl saturated,strip
R1600 T5407 T5406 prep with,saturated
R1601 T5408 T5409 nummod 10,%
R1602 T5409 T5410 compound %,FeCl3
R1603 T5410 T5411 compound FeCl3,solution
R1604 T5411 T5407 pobj solution,with
R1605 T5412 T5395 auxpass was,applied
R1606 T5413 T5395 prep to,applied
R1607 T5414 T5415 det the,surface
R1608 T5415 T5413 pobj surface,to
R1609 T5416 T5415 prep of,surface
R1610 T5417 T5418 det the,artery
R1611 T5418 T5416 pobj artery,of
R1612 T5419 T5418 amod carotid,artery
R1613 T5420 T5395 prep for,applied
R1614 T5421 T5422 nummod 3,min
R1615 T5422 T5420 pobj min,for
R1616 T5423 T5395 punct .,applied
R1617 T5425 T5426 compound Occlusion,time
R1618 T5426 T5427 nsubjpass time,determined
R1619 T5428 T5427 auxpass was,determined
R1620 T5429 T5427 prep from,determined
R1621 T5430 T5431 det the,addition
R1622 T5431 T5429 pobj addition,from
R1623 T5432 T5431 prep of,addition
R1624 T5433 T5434 det the,solution
R1625 T5434 T5432 pobj solution,of
R1626 T5435 T5434 compound FeCl3,solution
R1627 T5436 T5429 prep to,from
R1628 T5437 T5438 det the,occlusion
R1629 T5438 T5436 pobj occlusion,to
R1630 T5439 T5438 prep of,occlusion
R1631 T5440 T5441 det the,artery
R1632 T5441 T5439 pobj artery,of
R1633 T5442 T5438 punct (,occlusion
R1634 T5443 T5444 compound minimum,flow
R1635 T5444 T5438 appos flow,occlusion
R1636 T5445 T5444 compound blood,flow
R1637 T5446 T5427 punct ),determined
R1638 T5447 T5427 punct .,determined
R1639 T5449 T5450 det The,probe
R1640 T5450 T5452 nsubj probe,was
R1641 T5451 T5450 compound flow,probe
R1642 T5453 T5452 prep in,was
R1643 T5454 T5453 pobj place,in
R1644 T5455 T5452 prep from,was
R1645 T5456 T5457 det the,establishment
R1646 T5457 T5455 pobj establishment,from
R1647 T5458 T5457 prep of,establishment
R1648 T5459 T5460 det the,baseline
R1649 T5460 T5458 pobj baseline,of
R1650 T5461 T5455 prep until,from
R1651 T5462 T5463 amod several,min
R1652 T5463 T5464 npadvmod min,reached
R1653 T5464 T5461 pcomp reached,until
R1654 T5465 T5464 mark after,reached
R1655 T5466 T5467 det the,occlusion
R1656 T5467 T5464 nsubjpass occlusion,reached
R1657 T5468 T5467 amod stable,occlusion
R1658 T5469 T5464 aux had,reached
R1659 T5470 T5464 auxpass been,reached
R1660 T5471 T5452 cc or,was
R1661 T5472 T5452 conj stopped,was
R1662 T5473 T5472 prep at,stopped
R1663 T5474 T5475 nummod 30,min
R1664 T5475 T5473 pobj min,at
R1665 T5476 T5477 mark if,occluded
R1666 T5477 T5472 advcl occluded,stopped
R1667 T5478 T5477 nsubj it,occluded
R1668 T5479 T5477 aux had,occluded
R1669 T5480 T5477 neg not,occluded
R1670 T5481 T5452 punct .,was
R1671 T5483 T5484 compound Blood,flow
R1672 T5484 T5485 nsubjpass flow,recorded
R1673 T5486 T5485 auxpass was,recorded
R1674 T5487 T5488 det every,sec
R1675 T5488 T5485 npadvmod sec,recorded
R1676 T5489 T5488 nummod 10,sec
R1677 T5490 T5491 punct (,TS420
R1678 T5491 T5485 parataxis TS420,recorded
R1679 T5492 T5493 compound Transonic,Systems
R1680 T5493 T5491 dep Systems,TS420
R1681 T5494 T5491 punct ", ",TS420
R1682 T5495 T5491 compound model,TS420
R1683 T5496 T5491 punct ),TS420
R1684 T5497 T5485 punct .,recorded
R1685 T5499 T5500 expl There,was
R1686 T5501 T5502 det no,difference
R1687 T5502 T5500 attr difference,was
R1688 T5503 T5502 prep in,difference
R1689 T5504 T5505 compound body,weight
R1690 T5505 T5503 pobj weight,in
R1691 T5506 T5500 prep among,was
R1692 T5507 T5508 det the,mice
R1693 T5508 T5506 pobj mice,among
R1694 T5509 T5510 dep that,tested
R1695 T5510 T5508 relcl tested,mice
R1696 T5511 T5510 auxpass were,tested
R1697 T5512 T5510 prep in,tested
R1698 T5513 T5514 det the,model
R1699 T5514 T5512 pobj model,in
R1700 T5515 T5516 amod vascular,injury
R1701 T5516 T5514 compound injury,model
R1702 T5517 T5500 punct .,was
R1703 T5752 T5753 nmod Bleeding,assay
R1704 T5754 T5752 cc and,Bleeding
R1705 T5755 T5752 conj rebleeding,Bleeding
R1706 T5757 T5758 prep For,anesthetized
R1707 T5758 T5766 ccomp anesthetized,prewarmed
R1708 T5759 T5760 det the,assay
R1709 T5760 T5757 pobj assay,For
R1710 T5761 T5762 compound tail,bleeding
R1711 T5762 T5760 compound bleeding,assay
R1712 T5763 T5758 punct ", ",anesthetized
R1713 T5764 T5758 nsubjpass mice,anesthetized
R1714 T5765 T5758 auxpass were,anesthetized
R1715 T5767 T5758 prep with,anesthetized
R1716 T5768 T5769 compound ketamine,xylazine
R1717 T5769 T5767 pobj xylazine,with
R1718 T5770 T5769 punct /,xylazine
R1719 T5771 T5772 punct (,mg
R1720 T5772 T5769 parataxis mg,xylazine
R1721 T5773 T5774 nummod 80,mg
R1722 T5774 T5772 dep mg,mg
R1723 T5775 T5776 punct /,kg
R1724 T5776 T5774 prep kg,mg
R1725 T5777 T5772 punct ", ",mg
R1726 T5778 T5772 nummod 5,mg
R1727 T5779 T5780 punct /,kg
R1728 T5780 T5772 prep kg,mg
R1729 T5781 T5772 punct ),mg
R1730 T5782 T5766 punct ", ",prewarmed
R1731 T5783 T5784 det the,tail
R1732 T5784 T5766 nsubj tail,prewarmed
R1733 T5785 T5766 prep for,prewarmed
R1734 T5786 T5787 nummod 5,min
R1735 T5787 T5785 pobj min,for
R1736 T5788 T5766 prep in,prewarmed
R1737 T5789 T5790 nummod 10,mL
R1738 T5790 T5788 pobj mL,in
R1739 T5791 T5790 prep of,mL
R1740 T5792 T5791 pobj saline,of
R1741 T5793 T5792 prep at,saline
R1742 T5794 T5795 nummod 37,°C
R1743 T5795 T5793 pobj °C,at
R1744 T5796 T5766 prep in,prewarmed
R1745 T5797 T5798 det a,bath
R1746 T5798 T5796 pobj bath,in
R1747 T5799 T5798 compound water,bath
R1748 T5800 T5766 punct .,prewarmed
R1749 T5802 T5803 det The,tail
R1750 T5803 T5804 nsubjpass tail,lifted
R1751 T5805 T5804 auxpass was,lifted
R1752 T5806 T5804 prep from,lifted
R1753 T5807 T5808 det the,saline
R1754 T5808 T5806 pobj saline,from
R1755 T5809 T5804 cc and,lifted
R1756 T5810 T5811 det a,segment
R1757 T5811 T5815 nsubj segment,amputated
R1758 T5812 T5813 nummod 5,mm
R1759 T5813 T5811 compound mm,segment
R1760 T5814 T5811 compound tail,segment
R1761 T5815 T5804 conj amputated,lifted
R1762 T5816 T5815 cc and,amputated
R1763 T5817 T5818 advmod immediately,returned
R1764 T5818 T5815 conj returned,amputated
R1765 T5819 T5818 prep to,returned
R1766 T5820 T5821 det the,saline
R1767 T5821 T5819 pobj saline,to
R1768 T5822 T5815 punct .,amputated
R1769 T5824 T5825 compound Bleeding,time
R1770 T5825 T5826 nsubjpass time,measured
R1771 T5827 T5826 auxpass was,measured
R1772 T5828 T5826 prep as,measured
R1773 T5829 T5830 det the,time
R1774 T5830 T5828 pobj time,as
R1775 T5831 T5830 prep between,time
R1776 T5832 T5833 det the,start
R1777 T5833 T5831 pobj start,between
R1778 T5834 T5833 prep of,start
R1779 T5835 T5834 pobj bleeding,of
R1780 T5836 T5831 prep to,between
R1781 T5837 T5836 pobj cessation,to
R1782 T5838 T5837 prep of,cessation
R1783 T5839 T5838 pobj bleeding,of
R1784 T5840 T5826 punct .,measured
R1785 T5842 T5843 prep With,measured
R1786 T5844 T5845 det the,tail
R1787 T5845 T5846 nsubj tail,remaining
R1788 T5846 T5842 pcomp remaining,With
R1789 T5847 T5846 prep in,remaining
R1790 T5848 T5849 det the,solution
R1791 T5849 T5847 pobj solution,in
R1792 T5850 T5849 amod same,solution
R1793 T5851 T5849 compound saline,solution
R1794 T5852 T5843 punct ", ",measured
R1795 T5853 T5854 det the,time
R1796 T5854 T5843 nsubjpass time,measured
R1797 T5855 T5854 compound rebleeding,time
R1798 T5856 T5843 auxpass was,measured
R1799 T5857 T5843 prep from,measured
R1800 T5858 T5859 det the,time
R1801 T5859 T5857 pobj time,from
R1802 T5860 T5859 prep between,time
R1803 T5861 T5862 compound bleeding,cessation
R1804 T5862 T5860 pobj cessation,between
R1805 T5863 T5862 cc and,cessation
R1806 T5864 T5865 det the,start
R1807 T5865 T5862 conj start,cessation
R1808 T5866 T5865 prep of,start
R1809 T5867 T5868 det the,bleeding
R1810 T5868 T5866 pobj bleeding,of
R1811 T5869 T5868 amod second,bleeding
R1812 T5870 T5843 punct .,measured
R1813 T6393 T6394 nmod Coagulation,assays
R1814 T6395 T6393 punct ", ",Coagulation
R1815 T6396 T6393 conj Plg,Coagulation
R1816 T6397 T6396 punct ", ",Plg
R1817 T6398 T6399 compound α2,antiplasmin
R1818 T6399 T6396 conj antiplasmin,Plg
R1819 T6400 T6399 punct -,antiplasmin
R1820 T6401 T6399 punct ", ",antiplasmin
R1821 T6402 T6399 conj fibrinogen,antiplasmin
R1822 T6403 T6402 punct ", ",fibrinogen
R1823 T6404 T6402 conj fibrinolytic,fibrinogen
R1824 T6405 T6404 cc and,fibrinolytic
R1825 T6406 T6404 conj PAI,fibrinolytic
R1826 T6407 T6406 punct -,PAI
R1827 T6408 T6406 nummod 1,PAI
R1828 T6410 T6411 nsubjpass Mice,anesthetized
R1829 T6412 T6411 auxpass were,anesthetized
R1830 T6413 T6411 prep with,anesthetized
R1831 T6414 T6413 pobj Isoflurane,with
R1832 T6415 T6416 punct (,Abbott
R1833 T6416 T6414 parataxis Abbott,Isoflurane
R1834 T6417 T6416 punct ),Abbott
R1835 T6418 T6411 punct ", ",anesthetized
R1836 T6419 T6411 dep bled,anesthetized
R1837 T6420 T6419 prep from,bled
R1838 T6421 T6422 det the,sinus
R1839 T6422 T6420 pobj sinus,from
R1840 T6423 T6422 amod orbital,sinus
R1841 T6424 T6419 prep into,bled
R1842 T6425 T6426 amod uncoated,tubes
R1843 T6426 T6424 pobj tubes,into
R1844 T6427 T6426 amod capillary,tubes
R1845 T6428 T6411 punct ", ",anesthetized
R1846 T6429 T6411 cc and,anesthetized
R1847 T6430 T6431 det a,drop
R1848 T6431 T6432 nsubj drop,placed
R1849 T6432 T6411 conj placed,anesthetized
R1850 T6433 T6431 prep of,drop
R1851 T6434 T6433 pobj blood,of
R1852 T6435 T6432 advmod immediately,placed
R1853 T6436 T6432 prep on,placed
R1854 T6437 T6438 det a,strip
R1855 T6438 T6436 pobj strip,on
R1856 T6439 T6438 compound reagent,strip
R1857 T6440 T6441 punct (,Synbiotics
R1858 T6441 T6438 parataxis Synbiotics,strip
R1859 T6442 T6441 punct ),Synbiotics
R1860 T6443 T6432 prep for,placed
R1861 T6444 T6445 nmod prothrombin,time
R1862 T6445 T6446 nmod time,determinations
R1863 T6446 T6443 pobj determinations,for
R1864 T6447 T6445 punct (,time
R1865 T6448 T6445 appos PT,time
R1866 T6449 T6445 punct ),time
R1867 T6450 T6445 cc or,time
R1868 T6451 T6452 amod activated,time
R1869 T6452 T6445 conj time,time
R1870 T6453 T6452 amod partial,time
R1871 T6454 T6452 compound thromboplastin,time
R1872 T6455 T6452 punct (,time
R1873 T6456 T6452 appos aPTT,time
R1874 T6457 T6446 punct ),determinations
R1875 T6458 T6432 cc and,placed
R1876 T6459 T6432 conj inserted,placed
R1877 T6460 T6459 prep into,inserted
R1878 T6461 T6462 det the,Analyzer
R1879 T6462 T6460 pobj Analyzer,into
R1880 T6463 T6462 amod precalibrated,Analyzer
R1881 T6464 T6462 compound Coagulation,Analyzer
R1882 T6465 T6466 punct (,Synbiotics
R1883 T6466 T6462 parataxis Synbiotics,Analyzer
R1884 T6467 T6466 dep SCA2000,Synbiotics
R1885 T6468 T6466 punct ", ",Synbiotics
R1886 T6469 T6466 punct ),Synbiotics
R1887 T6470 T6432 punct .,placed
R1888 T6472 T6473 nmod PAI,activity
R1889 T6473 T6476 nsubjpass activity,determined
R1890 T6474 T6472 punct -,PAI
R1891 T6475 T6472 nummod 1,PAI
R1892 T6477 T6476 auxpass was,determined
R1893 T6478 T6476 prep according,determined
R1894 T6479 T6478 prep to,according
R1895 T6480 T6481 det the,method
R1896 T6481 T6479 pobj method,to
R1897 T6482 T6481 prep of,method
R1898 T6483 T6482 pobj Chandler,of
R1899 T6484 T6485 advmod et,al
R1900 T6485 T6483 advmod al,Chandler
R1901 T6486 T6487 punct [,20
R1902 T6487 T6483 parataxis 20,Chandler
R1903 T6488 T6487 punct ],20
R1904 T6489 T6476 punct .,determined
R1905 T6491 T6492 nmod PAI,concentration
R1906 T6492 T6496 nsubjpass concentration,determined
R1907 T6493 T6491 punct -,PAI
R1908 T6494 T6491 nummod 1,PAI
R1909 T6495 T6492 compound antigen,concentration
R1910 T6497 T6496 auxpass was,determined
R1911 T6498 T6496 prep by,determined
R1912 T6499 T6498 pobj ELISA,by
R1913 T6500 T6501 punct [,21
R1914 T6501 T6499 parataxis 21,ELISA
R1915 T6502 T6501 punct ],21
R1916 T6503 T6496 advcl using,determined
R1917 T6504 T6505 nmod sheep,PAI
R1918 T6505 T6503 dobj PAI,using
R1919 T6506 T6505 punct -,PAI
R1920 T6507 T6508 nmod anti,mouse
R1921 T6508 T6505 amod mouse,PAI
R1922 T6509 T6505 punct -,PAI
R1923 T6510 T6505 nummod 1,PAI
R1924 T6511 T6512 punct (,Diagnostica
R1925 T6512 T6505 parataxis Diagnostica,PAI
R1926 T6513 T6512 compound American,Diagnostica
R1927 T6514 T6512 punct ),Diagnostica
R1928 T6515 T6503 prep as,using
R1929 T6516 T6517 det the,antibody
R1930 T6517 T6515 pobj antibody,as
R1931 T6518 T6517 compound capture,antibody
R1932 T6519 T6503 cc and,using
R1933 T6520 T6521 compound mouse,PAI
R1934 T6521 T6503 conj PAI,using
R1935 T6522 T6521 punct -,PAI
R1936 T6523 T6521 nummod 1,PAI
R1937 T6524 T6525 punct (,Diagnostica
R1938 T6525 T6521 parataxis Diagnostica,PAI
R1939 T6526 T6525 compound American,Diagnostica
R1940 T6527 T6525 punct ),Diagnostica
R1941 T6528 T6521 prep as,PAI
R1942 T6529 T6530 det the,standard
R1943 T6530 T6528 pobj standard,as
R1944 T6531 T6532 punct (,ng
R1945 T6532 T6530 parataxis ng,standard
R1946 T6533 T6534 quantmod 0,3.5
R1947 T6534 T6532 nummod 3.5,ng
R1948 T6535 T6534 punct –,3.5
R1949 T6536 T6537 punct /,mL
R1950 T6537 T6532 prep mL,ng
R1951 T6538 T6532 punct ),ng
R1952 T6539 T6496 punct .,determined
R1953 T6541 T6542 nsubjpass Plg,determined
R1954 T6543 T6542 auxpass was,determined
R1955 T6544 T6542 prep with,determined
R1956 T6545 T6546 det a,assay
R1957 T6546 T6544 pobj assay,with
R1958 T6547 T6546 amod chromogenic,assay
R1959 T6548 T6549 punct [,22
R1960 T6549 T6542 parataxis 22,determined
R1961 T6550 T6549 punct ],22
R1962 T6551 T6542 cc and,determined
R1963 T6552 T6553 det the,activity
R1964 T6553 T6555 nsubj activity,determined
R1965 T6554 T6553 amod fibrinolytic,activity
R1966 T6555 T6542 conj determined,determined
R1967 T6556 T6555 prep by,determined
R1968 T6557 T6558 compound fibrin,degradation
R1969 T6558 T6556 pobj degradation,by
R1970 T6559 T6560 punct [,23
R1971 T6560 T6555 parataxis 23,determined
R1972 T6561 T6560 punct ],23
R1973 T6562 T6555 punct .,determined
R1974 T6564 T6565 prep For,used
R1975 T6566 T6567 det the,controls
R1976 T6567 T6564 pobj controls,For
R1977 T6568 T6567 amod negative,controls
R1978 T6569 T6567 prep in,controls
R1979 T6570 T6571 det these,assays
R1980 T6571 T6569 pobj assays,in
R1981 T6572 T6565 punct ", ",used
R1982 T6573 T6565 nsubjpass plasma,used
R1983 T6574 T6573 prep from,plasma
R1984 T6575 T6576 npadvmod PAI,deficient
R1985 T6576 T6581 amod deficient,mice
R1986 T6577 T6575 punct -,PAI
R1987 T6578 T6575 nummod 1,PAI
R1988 T6579 T6575 cc or,PAI
R1989 T6580 T6575 conj Plg,PAI
R1990 T6581 T6574 pobj mice,from
R1991 T6582 T6565 auxpass was,used
R1992 T6583 T6565 punct .,used
R1993 T6585 T6586 advmod Functionally,active
R1994 T6586 T6587 amod active,antiplasmin
R1995 T6587 T6591 nsubjpass antiplasmin,determined
R1996 T6588 T6587 compound mouse,antiplasmin
R1997 T6589 T6587 compound α2,antiplasmin
R1998 T6590 T6587 punct -,antiplasmin
R1999 T6592 T6591 auxpass was,determined
R2000 T6593 T6591 prep with,determined
R2001 T6594 T6595 det a,assay
R2002 T6595 T6593 pobj assay,with
R2003 T6596 T6597 compound plasmin,capture
R2004 T6597 T6595 compound capture,assay
R2005 T6598 T6595 cc and,assay
R2006 T6599 T6595 conj detection,assay
R2007 T6600 T6599 prep with,detection
R2008 T6601 T6602 det a,antibody
R2009 T6602 T6600 pobj antibody,with
R2010 T6603 T6602 compound mouse,antibody
R2011 T6604 T6605 punct (,Innovations
R2012 T6605 T6602 parataxis Innovations,antibody
R2013 T6606 T6605 compound Molecular,Innovations
R2014 T6607 T6605 punct ", ",Innovations
R2015 T6608 T6605 npadvmod Southfield,Innovations
R2016 T6609 T6605 punct ", ",Innovations
R2017 T6610 T6605 npadvmod MI,Innovations
R2018 T6611 T6605 punct ),Innovations
R2019 T6612 T6591 punct ", ",determined
R2020 T6613 T6591 cc and,determined
R2021 T6614 T6591 conj fibrinogen,determined
R2022 T6615 T6614 prep with,fibrinogen
R2023 T6616 T6617 det an,assay
R2024 T6617 T6615 pobj assay,with
R2025 T6618 T6617 compound ELISA,assay
R2026 T6619 T6617 prep with,assay
R2027 T6620 T6619 pobj antibodies,with
R2028 T6621 T6622 dep that,recognize
R2029 T6622 T6620 relcl recognize,antibodies
R2030 T6623 T6624 compound mouse,fibrinogen
R2031 T6624 T6622 dobj fibrinogen,recognize
R2032 T6625 T6626 punct (,BioMed
R2033 T6626 T6620 parataxis BioMed,antibodies
R2034 T6627 T6626 compound Hyphen,BioMed
R2035 T6628 T6626 punct ", ",BioMed
R2036 T6629 T6626 npadvmod France,BioMed
R2037 T6630 T6626 punct ),BioMed
R2038 T6631 T6614 punct .,fibrinogen
R2039 T6809 T6810 amod Histochemical,analysis
R2040 T6811 T6809 cc and,Histochemical
R2041 T6812 T6809 conj immunohistochemistry,Histochemical
R2042 T6814 T6815 det The,tails
R2043 T6815 T6817 nsubjpass tails,sectioned
R2044 T6816 T6815 amod frozen,tails
R2045 T6818 T6815 cc or,tails
R2046 T6819 T6820 amod injured,carotids
R2047 T6820 T6815 conj carotids,tails
R2048 T6821 T6815 prep in,tails
R2049 T6822 T6821 pobj OCT,in
R2050 T6823 T6817 auxpass were,sectioned
R2051 T6824 T6817 prep at,sectioned
R2052 T6825 T6826 nummod 5,μm
R2053 T6826 T6827 compound μm,thickness
R2054 T6827 T6824 pobj thickness,at
R2055 T6828 T6817 cc and,sectioned
R2056 T6829 T6817 conj stained,sectioned
R2057 T6830 T6829 prep with,stained
R2058 T6831 T6832 poss Masson,Trichrome
R2059 T6832 T6830 pobj Trichrome,with
R2060 T6833 T6831 case 's,Masson
R2061 T6834 T6835 punct (,Diagnostics
R2062 T6835 T6832 parataxis Diagnostics,Trichrome
R2063 T6836 T6835 dep HT,Diagnostics
R2064 T6837 T6836 nummod 15,HT
R2065 T6838 T6835 punct ", ",Diagnostics
R2066 T6839 T6835 compound Sigma,Diagnostics
R2067 T6840 T6835 punct ),Diagnostics
R2068 T6841 T6817 punct .,sectioned
R2069 T6843 T6844 prep For,measured
R2070 T6845 T6846 amod quantitative,analysis
R2071 T6846 T6843 pobj analysis,For
R2072 T6847 T6846 prep of,analysis
R2073 T6848 T6849 compound collagen,area
R2074 T6849 T6847 pobj area,of
R2075 T6850 T6846 prep in,analysis
R2076 T6851 T6852 det the,sections
R2077 T6852 T6850 pobj sections,in
R2078 T6853 T6852 compound tail,sections
R2079 T6854 T6844 punct ", ",measured
R2080 T6855 T6856 nummod four,sections
R2081 T6856 T6844 nsubjpass sections,measured
R2082 T6857 T6856 prep from,sections
R2083 T6858 T6859 quantmod 2,3
R2084 T6859 T6861 nummod 3,sites
R2085 T6860 T6859 punct –,3
R2086 T6861 T6857 pobj sites,from
R2087 T6862 T6844 auxpass were,measured
R2088 T6863 T6844 advcl using,measured
R2089 T6864 T6865 npadvmod computer,assisted
R2090 T6865 T6866 amod assisted,analysis
R2091 T6866 T6863 dobj analysis,using
R2092 T6867 T6866 compound image,analysis
R2093 T6868 T6869 punct (,Cybernetics
R2094 T6869 T6863 parataxis Cybernetics,using
R2095 T6870 T6871 compound Image,Plus
R2096 T6871 T6869 dep Plus,Cybernetics
R2097 T6872 T6871 punct -,Plus
R2098 T6873 T6871 compound Pro,Plus
R2099 T6874 T6869 punct ", ",Cybernetics
R2100 T6875 T6869 punct ),Cybernetics
R2101 T6876 T6844 punct .,measured
R2102 T6878 T6879 prep For,analyzed
R2103 T6880 T6881 det the,determination
R2104 T6881 T6878 pobj determination,For
R2105 T6882 T6881 compound area,determination
R2106 T6883 T6881 prep of,determination
R2107 T6884 T6885 det the,lumen
R2108 T6885 T6883 pobj lumen,of
R2109 T6886 T6885 amod injured,lumen
R2110 T6887 T6885 compound carotid,lumen
R2111 T6888 T6879 punct ", ",analyzed
R2112 T6889 T6890 quantmod 3,4
R2113 T6890 T6892 nummod 4,sections
R2114 T6891 T6890 punct –,4
R2115 T6892 T6879 nsubjpass sections,analyzed
R2116 T6893 T6892 prep from,sections
R2117 T6894 T6895 amod different,sites
R2118 T6895 T6893 pobj sites,from
R2119 T6896 T6897 advmod approximately,100
R2120 T6897 T6898 nummod 100,μm
R2121 T6898 T6899 npadvmod μm,apart
R2122 T6899 T6895 advmod apart,sites
R2123 T6900 T6879 auxpass were,analyzed
R2124 T6901 T6879 cc and,analyzed
R2125 T6902 T6879 conj averaged,analyzed
R2126 T6903 T6902 prep for,averaged
R2127 T6904 T6905 det each,mouse
R2128 T6905 T6903 pobj mouse,for
R2129 T6906 T6879 punct .,analyzed
R2130 T7167 T7168 nsubjpass Data,presented
R2131 T7169 T7168 auxpass are,presented
R2132 T7170 T7168 prep as,presented
R2133 T7171 T7172 nmod mean,SEM
R2134 T7172 T7170 pobj SEM,as
R2135 T7173 T7172 punct ±,SEM
R2136 T7174 T7168 punct .,presented
R2137 T7176 T7177 det The,analysis
R2138 T7177 T7179 nsubjpass analysis,compared
R2139 T7178 T7177 amod statistical,analysis
R2140 T7180 T7177 prep for,analysis
R2141 T7181 T7180 pobj comparisons,for
R2142 T7182 T7181 prep between,comparisons
R2143 T7183 T7184 nmod A,J
R2144 T7184 T7186 nmod J,mice
R2145 T7185 T7184 punct /,J
R2146 T7186 T7182 pobj mice,between
R2147 T7187 T7184 cc and,J
R2148 T7188 T7184 conj B6,J
R2149 T7189 T7182 cc and,between
R2150 T7190 T7182 conj between,between
R2151 T7191 T7192 amod wild,type
R2152 T7192 T7194 nmod type,littermates
R2153 T7193 T7192 punct -,type
R2154 T7194 T7190 pobj littermates,between
R2155 T7195 T7192 punct (,type
R2156 T7196 T7192 appos WT,type
R2157 T7197 T7192 punct ),type
R2158 T7198 T7192 cc and,type
R2159 T7199 T7192 conj Plg,type
R2160 T7200 T7199 punct -,Plg
R2161 T7201 T7199 punct /,Plg
R2162 T7202 T7199 punct -,Plg
R2163 T7203 T7179 auxpass was,compared
R2164 T7204 T7179 prep with,compared
R2165 T7205 T7206 det a,test
R2166 T7206 T7204 pobj test,with
R2167 T7207 T7208 advmod two,tailed
R2168 T7208 T7206 amod tailed,test
R2169 T7209 T7208 punct -,tailed
R2170 T7210 T7206 compound t,test
R2171 T7211 T7206 punct -,test
R2172 T7212 T7179 punct .,compared
R2173 T7214 T7215 nsubjpass Differences,determined
R2174 T7216 T7214 prep among,Differences
R2175 T7217 T7218 nmod B6,mice
R2176 T7218 T7216 pobj mice,among
R2177 T7219 T7217 punct ", ",B6
R2178 T7220 T7217 appos Lepob,B6
R2179 T7221 T7217 punct ", ",B6
R2180 T7222 T7217 appos PAI,B6
R2181 T7223 T7222 punct -,PAI
R2182 T7224 T7222 nummod 1,PAI
R2183 T7225 T7222 punct -,PAI
R2184 T7226 T7222 punct /,PAI
R2185 T7227 T7222 punct -,PAI
R2186 T7228 T7215 auxpass were,determined
R2187 T7229 T7215 agent by,determined
R2188 T7230 T7231 det a,ANOVA
R2189 T7231 T7229 pobj ANOVA,by
R2190 T7232 T7233 nummod one,way
R2191 T7233 T7231 compound way,ANOVA
R2192 T7234 T7233 punct -,way
R2193 T7235 T7231 cc and,ANOVA
R2194 T7236 T7237 det a,post-test
R2195 T7237 T7231 conj post-test,ANOVA
R2196 T7238 T7239 compound Newman,Keuls
R2197 T7239 T7237 compound Keuls,post-test
R2198 T7240 T7239 punct -,Keuls
R2199 T7241 T7215 punct .,determined
R2200 T7243 T7244 det A,value
R2201 T7244 T7245 nsubjpass value,considered
R2202 T7246 T7244 prep of,value
R2203 T7247 T7246 pobj P,of
R2204 T7248 T7249 punct <,0.05
R2205 T7249 T7247 amod 0.05,P
R2206 T7250 T7245 auxpass was,considered
R2207 T7251 T7245 oprd significant,considered
R2208 T7252 T7245 punct .,considered
R2209 T7254 T7255 det The,analysis
R2210 T7255 T7257 nsubjpass analysis,determined
R2211 T7256 T7255 amod statistical,analysis
R2212 T7258 T7255 prep for,analysis
R2213 T7259 T7258 pobj comparisons,for
R2214 T7260 T7259 prep between,comparisons
R2215 T7261 T7262 compound B6,mice
R2216 T7262 T7260 pobj mice,between
R2217 T7263 T7262 cc and,mice
R2218 T7264 T7262 conj CSS,mice
R2219 T7265 T7257 auxpass were,determined
R2220 T7266 T7257 prep with,determined
R2221 T7267 T7268 nummod two,tail
R2222 T7268 T7270 compound tail,tests
R2223 T7269 T7268 punct -,tail
R2224 T7270 T7266 pobj tests,with
R2225 T7271 T7270 compound t,tests
R2226 T7272 T7270 punct -,tests
R2227 T7273 T7257 cc and,determined
R2228 T7274 T7275 det the,level
R2229 T7275 T7276 nsubj level,determined
R2230 T7276 T7257 conj determined,determined
R2231 T7277 T7275 prep of,level
R2232 T7278 T7279 det the,values
R2233 T7279 T7277 pobj values,of
R2234 T7280 T7279 amod significant,values
R2235 T7281 T7279 compound P,values
R2236 T7282 T7279 punct -,values
R2237 T7283 T7284 punct (,see
R2238 T7284 T7275 parataxis see,level
R2239 T7285 T7286 compound figure,legends
R2240 T7286 T7284 dobj legends,see
R2241 T7287 T7284 punct ),see
R2242 T7288 T7276 prep with,determined
R2243 T7289 T7290 det a,correction
R2244 T7290 T7288 pobj correction,with
R2245 T7291 T7290 compound Bonferroni,correction
R2246 T7292 T7293 aux to,account
R2247 T7293 T7290 advcl account,correction
R2248 T7294 T7293 prep for,account
R2249 T7295 T7296 compound multihypothesis,testing
R2250 T7296 T7294 pobj testing,for
R2251 T7297 T7298 punct [,13
R2252 T7298 T7276 parataxis 13,determined
R2253 T7299 T7298 punct ],13
R2254 T7300 T7276 punct .,determined
R2255 T8036 T8037 amod Marked,differences
R2256 T8038 T8037 prep in,differences
R2257 T8039 T8040 amod arterial,thrombus
R2258 T8040 T8041 compound thrombus,formation
R2259 T8041 T8038 pobj formation,in
R2260 T8042 T8037 prep in,differences
R2261 T8043 T8044 nmod B6,mice
R2262 T8044 T8042 pobj mice,in
R2263 T8045 T8043 cc and,B6
R2264 T8046 T8047 compound A,J
R2265 T8047 T8043 conj J,B6
R2266 T8048 T8047 punct /,J
R2267 T8050 T8051 det The,model
R2268 T8051 T8056 nsubjpass model,used
R2269 T8052 T8051 nmod FeCl3,model
R2270 T8053 T8054 amod cartoid,artery
R2271 T8054 T8051 compound artery,model
R2272 T8055 T8051 compound injury,model
R2273 T8057 T8058 punct [,24
R2274 T8058 T8051 parataxis 24,model
R2275 T8059 T8058 punct ],24
R2276 T8060 T8051 punct ", ",model
R2277 T8061 T8062 det a,model
R2278 T8062 T8051 appos model,model
R2279 T8063 T8064 amod well,characterized
R2280 T8064 T8062 amod characterized,model
R2281 T8065 T8064 punct -,characterized
R2282 T8066 T8067 amod arterial,thrombosis
R2283 T8067 T8062 compound thrombosis,model
R2284 T8068 T8056 punct ", ",used
R2285 T8069 T8056 auxpass was,used
R2286 T8070 T8071 aux to,induce
R2287 T8071 T8056 advcl induce,used
R2288 T8072 T8073 det an,thrombus
R2289 T8073 T8071 dobj thrombus,induce
R2290 T8074 T8073 amod occlusive,thrombus
R2291 T8075 T8071 prep in,induce
R2292 T8076 T8077 det the,strains
R2293 T8077 T8075 pobj strains,in
R2294 T8078 T8077 nmod B6,strains
R2295 T8079 T8078 cc and,B6
R2296 T8080 T8081 compound A,J
R2297 T8081 T8078 conj J,B6
R2298 T8082 T8081 punct /,J
R2299 T8083 T8077 compound mouse,strains
R2300 T8084 T8077 prep under,strains
R2301 T8085 T8084 pobj investigation,under
R2302 T8086 T8056 punct .,used
R2303 T8088 T8089 det A,difference
R2304 T8089 T8091 nsubjpass difference,found
R2305 T8090 T8089 amod marked,difference
R2306 T8092 T8089 prep in,difference
R2307 T8093 T8094 amod arterial,thrombus
R2308 T8094 T8095 compound thrombus,occlusion
R2309 T8095 T8096 compound occlusion,time
R2310 T8096 T8092 pobj time,in
R2311 T8097 T8091 auxpass was,found
R2312 T8098 T8091 prep between,found
R2313 T8099 T8100 det the,B6
R2314 T8100 T8098 pobj B6,between
R2315 T8101 T8100 cc and,B6
R2316 T8102 T8103 det the,J
R2317 T8103 T8106 compound J,mice
R2318 T8104 T8103 compound A,J
R2319 T8105 T8103 punct /,J
R2320 T8106 T8100 conj mice,B6
R2321 T8107 T8108 punct (,1A
R2322 T8108 T8091 parataxis 1A,found
R2323 T8109 T8108 compound Figure,1A
R2324 T8110 T8108 punct ),1A
R2325 T8111 T8091 punct .,found
R2326 T8113 T8114 det The,time
R2327 T8114 T8116 nsubj time,was
R2328 T8115 T8114 compound occlusion,time
R2329 T8117 T8114 prep in,time
R2330 T8118 T8119 det the,mice
R2331 T8119 T8117 pobj mice,in
R2332 T8120 T8121 compound A,J
R2333 T8121 T8119 compound J,mice
R2334 T8122 T8121 punct /,J
R2335 T8123 T8124 advmod 2-fold,less
R2336 T8124 T8116 acomp less,was
R2337 T8125 T8124 prep than,less
R2338 T8126 T8125 prep for,than
R2339 T8127 T8128 det the,mice
R2340 T8128 T8126 pobj mice,for
R2341 T8129 T8128 compound B6,mice
R2342 T8130 T8116 punct .,was
R2343 T8132 T8133 det A,dose
R2344 T8133 T8136 nsubjpass dose,tested
R2345 T8134 T8135 nummod 5,%
R2346 T8135 T8133 compound %,dose
R2347 T8137 T8133 prep of,dose
R2348 T8138 T8137 pobj FeCl3,of
R2349 T8139 T8136 auxpass was,tested
R2350 T8140 T8136 prep in,tested
R2351 T8141 T8142 det the,mice
R2352 T8142 T8140 pobj mice,in
R2353 T8143 T8144 nmod A,J
R2354 T8144 T8142 nmod J,mice
R2355 T8145 T8144 punct /,J
R2356 T8146 T8144 cc and,J
R2357 T8147 T8144 conj B6,J
R2358 T8148 T8136 cc and,tested
R2359 T8149 T8150 det the,time
R2360 T8150 T8152 nsubj time,was
R2361 T8151 T8150 compound occlusion,time
R2362 T8152 T8136 conj was,tested
R2363 T8153 T8152 acomp lower,was
R2364 T8154 T8153 prep in,lower
R2365 T8155 T8156 det the,J
R2366 T8156 T8154 pobj J,in
R2367 T8157 T8156 compound A,J
R2368 T8158 T8156 punct /,J
R2369 T8159 T8153 prep than,lower
R2370 T8160 T8161 det the,B6
R2371 T8161 T8159 pobj B6,than
R2372 T8162 T8159 pobj mice,than
R2373 T8163 T8152 punct ", ",was
R2374 T8164 T8165 det the,results
R2375 T8165 T8152 npadvmod results,was
R2376 T8166 T8165 amod same,results
R2377 T8167 T8165 prep as,results
R2378 T8168 T8167 prep with,as
R2379 T8169 T8170 det the,dose
R2380 T8170 T8168 pobj dose,with
R2381 T8171 T8172 nummod 10,%
R2382 T8172 T8170 compound %,dose
R2383 T8173 T8152 punct .,was
R2384 T8175 T8176 det The,time
R2385 T8176 T8178 nsubj time,were
R2386 T8177 T8176 compound occlusion,time
R2387 T8179 T8180 punct (,min
R2388 T8180 T8176 parataxis min,time
R2389 T8181 T8180 prep for,min
R2390 T8182 T8183 preconj both,B6
R2391 T8183 T8181 pobj B6,for
R2392 T8184 T8185 punct (,3
R2393 T8185 T8183 parataxis 3,B6
R2394 T8186 T8185 quantmod 15,3
R2395 T8187 T8185 punct ±,3
R2396 T8188 T8185 punct ", ",3
R2397 T8189 T8190 nsubj n,3
R2398 T8190 T8185 ccomp 3,3
R2399 T8191 T8190 punct =,3
R2400 T8192 T8185 punct ),3
R2401 T8193 T8183 cc and,B6
R2402 T8194 T8195 compound A,J
R2403 T8195 T8183 conj J,B6
R2404 T8196 T8195 punct /,J
R2405 T8197 T8198 punct (,1
R2406 T8198 T8195 parataxis 1,J
R2407 T8199 T8198 quantmod 8,1
R2408 T8200 T8198 punct ±,1
R2409 T8201 T8198 punct ", ",1
R2410 T8202 T8203 nsubj n,3
R2411 T8203 T8198 ccomp 3,1
R2412 T8204 T8203 punct =,3
R2413 T8205 T8198 punct ),1
R2414 T8206 T8176 prep at,time
R2415 T8207 T8208 nummod 5,%
R2416 T8208 T8206 pobj %,at
R2417 T8209 T8178 acomp longer,were
R2418 T8210 T8209 prep than,longer
R2419 T8211 T8210 prep at,than
R2420 T8212 T8213 nummod 10,%
R2421 T8213 T8211 pobj %,at
R2422 T8214 T8178 prep for,were
R2423 T8215 T8214 pobj B6,for
R2424 T8216 T8217 punct (,1
R2425 T8217 T8215 parataxis 1,B6
R2426 T8218 T8217 quantmod 10,1
R2427 T8219 T8217 punct ±,1
R2428 T8220 T8217 punct ", ",1
R2429 T8221 T8222 nsubj n,17
R2430 T8222 T8217 ccomp 17,1
R2431 T8223 T8222 punct =,17
R2432 T8224 T8215 cc and,B6
R2433 T8225 T8226 compound A,J
R2434 T8226 T8215 conj J,B6
R2435 T8227 T8226 punct /,J
R2436 T8228 T8229 punct (,2
R2437 T8229 T8226 parataxis 2,J
R2438 T8230 T8229 quantmod 5,2
R2439 T8231 T8229 punct ±,2
R2440 T8232 T8229 punct ", ",2
R2441 T8233 T8234 nsubj n,14
R2442 T8234 T8229 ccomp 14,2
R2443 T8235 T8234 punct =,14
R2444 T8236 T8229 punct ),2
R2445 T8237 T8178 punct .,were
R2446 T8239 T8240 det The,curves
R2447 T8240 T8241 nsubj curves,indicated
R2448 T8242 T8240 prep of,curves
R2449 T8243 T8244 compound blood,flow
R2450 T8244 T8242 pobj flow,of
R2451 T8245 T8240 prep after,curves
R2452 T8246 T8247 compound FeCl3,application
R2453 T8247 T8245 pobj application,after
R2454 T8248 T8249 det a,pattern
R2455 T8249 T8241 dobj pattern,indicated
R2456 T8250 T8241 prep with,indicated
R2457 T8251 T8252 det a,decrease
R2458 T8252 T8250 pobj decrease,with
R2459 T8253 T8252 amod gradual,decrease
R2460 T8254 T8252 prep before,decrease
R2461 T8255 T8254 pobj occlusion,before
R2462 T8256 T8252 prep for,decrease
R2463 T8257 T8258 det the,mice
R2464 T8258 T8256 pobj mice,for
R2465 T8259 T8258 compound B6,mice
R2466 T8260 T8261 punct (,1B
R2467 T8261 T8241 parataxis 1B,indicated
R2468 T8262 T8261 compound Figure,1B
R2469 T8263 T8261 punct ),1B
R2470 T8264 T8241 punct ", ",indicated
R2471 T8265 T8241 cc but,indicated
R2472 T8266 T8267 prep for,decreased
R2473 T8267 T8241 conj decreased,indicated
R2474 T8268 T8269 det the,mice
R2475 T8269 T8266 pobj mice,for
R2476 T8270 T8271 compound A,J
R2477 T8271 T8269 compound J,mice
R2478 T8272 T8271 punct /,J
R2479 T8273 T8274 det the,flow
R2480 T8274 T8267 nsubj flow,decreased
R2481 T8275 T8274 compound blood,flow
R2482 T8276 T8267 advmod abruptly,decreased
R2483 T8277 T8267 prep to,decreased
R2484 T8278 T8277 pobj zero,to
R2485 T8279 T8280 punct (,1C
R2486 T8280 T8267 parataxis 1C,decreased
R2487 T8281 T8280 compound Figure,1C
R2488 T8282 T8280 punct ),1C
R2489 T8283 T8267 punct ", ",decreased
R2490 T8284 T8267 advcl demonstrating,decreased
R2491 T8285 T8286 det a,difference
R2492 T8286 T8284 dobj difference,demonstrating
R2493 T8287 T8286 amod marked,difference
R2494 T8288 T8286 prep from,difference
R2495 T8289 T8290 det the,strain
R2496 T8290 T8288 pobj strain,from
R2497 T8291 T8290 compound B6,strain
R2498 T8292 T8267 punct .,decreased
R2499 T8294 T8295 det The,times
R2500 T8295 T8298 nsubj times,were
R2501 T8296 T8295 amod mean,times
R2502 T8297 T8295 compound occlusion,times
R2503 T8299 T8300 advmod significantly,different
R2504 T8300 T8298 acomp different,were
R2505 T8301 T8298 prep between,were
R2506 T8302 T8303 det the,strains
R2507 T8303 T8301 pobj strains,between
R2508 T8304 T8303 nummod two,strains
R2509 T8305 T8306 punct (,1A
R2510 T8306 T8298 parataxis 1A,were
R2511 T8307 T8306 compound Figure,1A
R2512 T8308 T8306 punct ),1A
R2513 T8309 T8298 punct .,were
R2514 T8311 T8312 det The,size
R2515 T8312 T8313 nsubj size,was
R2516 T8314 T8312 prep of,size
R2517 T8315 T8316 det the,carotids
R2518 T8316 T8314 pobj carotids,of
R2519 T8317 T8312 prep in,size
R2520 T8318 T8319 det the,strains
R2521 T8319 T8317 pobj strains,in
R2522 T8320 T8319 nummod two,strains
R2523 T8321 T8322 advmod noticeably,different
R2524 T8322 T8313 acomp different,was
R2525 T8323 T8313 punct .,was
R2526 T8325 T8326 det The,area
R2527 T8326 T8327 nsubj area,was
R2528 T8328 T8329 punct (,mm2
R2529 T8329 T8326 parataxis mm2,area
R2530 T8330 T8329 punct ),mm2
R2531 T8331 T8326 prep of,area
R2532 T8332 T8333 det the,lumen
R2533 T8333 T8331 pobj lumen,of
R2534 T8334 T8335 punct (,0.007
R2535 T8335 T8333 parataxis 0.007,lumen
R2536 T8336 T8335 quantmod 0.066,0.007
R2537 T8337 T8335 punct ±,0.007
R2538 T8338 T8335 punct ", ",0.007
R2539 T8339 T8340 nsubj n,6
R2540 T8340 T8335 ccomp 6,0.007
R2541 T8341 T8340 punct =,6
R2542 T8342 T8335 punct ),0.007
R2543 T8343 T8344 advmod significantly,less
R2544 T8344 T8327 acomp less,was
R2545 T8345 T8327 prep in,was
R2546 T8346 T8347 det the,mice
R2547 T8347 T8345 pobj mice,in
R2548 T8348 T8349 nmod A,J
R2549 T8349 T8347 compound J,mice
R2550 T8350 T8349 punct /,J
R2551 T8351 T8327 prep than,was
R2552 T8352 T8351 prep for,than
R2553 T8353 T8354 compound B6,mice
R2554 T8354 T8352 pobj mice,for
R2555 T8355 T8356 punct (,0.007
R2556 T8356 T8327 parataxis 0.007,was
R2557 T8357 T8356 quantmod 0.128,0.007
R2558 T8358 T8356 punct ±,0.007
R2559 T8359 T8356 punct ", ",0.007
R2560 T8360 T8361 nsubj n,6
R2561 T8361 T8356 ccomp 6,0.007
R2562 T8362 T8361 punct =,6
R2563 T8363 T8356 punct ),0.007
R2564 T8364 T8327 punct .,was
R2565 T8366 T8367 advmod However,was
R2566 T8368 T8367 punct ", ",was
R2567 T8369 T8370 det the,ratio
R2568 T8370 T8367 nsubj ratio,was
R2569 T8371 T8370 prep of,ratio
R2570 T8372 T8373 det the,thrombus
R2571 T8373 T8371 pobj thrombus,of
R2572 T8374 T8370 prep to,ratio
R2573 T8375 T8374 pobj lumen,to
R2574 T8376 T8367 acomp similar,was
R2575 T8377 T8367 prep for,was
R2576 T8378 T8379 compound A,J
R2577 T8379 T8377 pobj J,for
R2578 T8380 T8379 punct /,J
R2579 T8381 T8382 punct (,0.03
R2580 T8382 T8379 parataxis 0.03,J
R2581 T8383 T8382 quantmod 0.63,0.03
R2582 T8384 T8382 punct ±,0.03
R2583 T8385 T8382 punct ),0.03
R2584 T8386 T8379 prep compared,J
R2585 T8387 T8386 prep to,compared
R2586 T8388 T8389 compound B6,mice
R2587 T8389 T8387 pobj mice,to
R2588 T8390 T8391 punct (,0.09
R2589 T8391 T8389 parataxis 0.09,mice
R2590 T8392 T8391 quantmod 0.67,0.09
R2591 T8393 T8391 punct ±,0.09
R2592 T8394 T8391 punct ),0.09
R2593 T8395 T8367 punct .,was
R2594 T8397 T8398 amod Calculated,rates
R2595 T8398 T8401 nsubj rates,were
R2596 T8399 T8398 compound sheer,rates
R2597 T8400 T8398 compound stress,rates
R2598 T8402 T8403 punct [,25
R2599 T8403 T8398 parataxis 25,rates
R2600 T8404 T8403 punct ],25
R2601 T8405 T8406 nummod 14,%
R2602 T8406 T8407 npadvmod %,less
R2603 T8407 T8401 acomp less,were
R2604 T8408 T8401 prep in,were
R2605 T8409 T8410 det the,mice
R2606 T8410 T8408 pobj mice,in
R2607 T8411 T8412 compound A,J
R2608 T8412 T8410 compound J,mice
R2609 T8413 T8412 punct /,J
R2610 T8414 T8415 advmod when,compared
R2611 T8415 T8401 advcl compared,were
R2612 T8416 T8415 prep to,compared
R2613 T8417 T8418 compound B6,mice
R2614 T8418 T8416 pobj mice,to
R2615 T8419 T8401 punct .,were
R2616 T9400 T9401 amod Marked,differences
R2617 T9402 T9401 prep in,differences
R2618 T9403 T9404 compound rebleeding,time
R2619 T9404 T9402 pobj time,in
R2620 T9405 T9401 prep in,differences
R2621 T9406 T9407 nmod B6,mice
R2622 T9407 T9405 pobj mice,in
R2623 T9408 T9406 cc and,B6
R2624 T9409 T9410 compound A,J
R2625 T9410 T9406 conj J,B6
R2626 T9411 T9410 punct /,J
R2627 T9413 T9414 det The,time
R2628 T9414 T9416 nsubjpass time,determined
R2629 T9415 T9414 compound bleeding,time
R2630 T9417 T9414 punct ", ",time
R2631 T9418 T9419 det an,indicator
R2632 T9419 T9414 appos indicator,time
R2633 T9420 T9419 prep of,indicator
R2634 T9421 T9422 amod hemostatic,activity
R2635 T9422 T9420 pobj activity,of
R2636 T9423 T9416 punct ", ",determined
R2637 T9424 T9416 auxpass was,determined
R2638 T9425 T9416 prep after,determined
R2639 T9426 T9425 pcomp prewarming,after
R2640 T9427 T9428 det the,tail
R2641 T9428 T9426 dobj tail,prewarming
R2642 T9429 T9426 punct ", ",prewarming
R2643 T9430 T9426 conj clipping,prewarming
R2644 T9431 T9432 det a,segment
R2645 T9432 T9430 dobj segment,clipping
R2646 T9433 T9434 nummod 5,mm
R2647 T9434 T9432 compound mm,segment
R2648 T9435 T9430 punct ", ",clipping
R2649 T9436 T9430 conj placing,clipping
R2650 T9437 T9438 det the,tail
R2651 T9438 T9436 dobj tail,placing
R2652 T9439 T9436 prep in,placing
R2653 T9440 T9441 amod warm,saline
R2654 T9441 T9439 pobj saline,in
R2655 T9442 T9436 cc and,placing
R2656 T9443 T9436 conj measuring,placing
R2657 T9444 T9445 det the,time
R2658 T9445 T9443 dobj time,measuring
R2659 T9446 T9447 mark for,stop
R2660 T9447 T9445 advcl stop,time
R2661 T9448 T9449 det the,bleeding
R2662 T9449 T9447 nsubj bleeding,stop
R2663 T9450 T9447 aux to,stop
R2664 T9451 T9416 punct .,determined
R2665 T9453 T9454 nsubj We,found
R2666 T9455 T9456 det this,procedure
R2667 T9456 T9457 nsubj procedure,was
R2668 T9457 T9454 advcl was,found
R2669 T9458 T9457 acomp consistent,was
R2670 T9459 T9458 cc and,consistent
R2671 T9460 T9458 conj reproducible,consistent
R2672 T9461 T9457 prep in,was
R2673 T9462 T9463 amod different,strains
R2674 T9463 T9461 pobj strains,in
R2675 T9464 T9463 compound mouse,strains
R2676 T9465 T9457 cc and,was
R2677 T9466 T9457 conj was,was
R2678 T9467 T9466 neg not,was
R2679 T9468 T9469 npadvmod gender,dependent
R2680 T9469 T9466 acomp dependent,was
R2681 T9470 T9454 punct .,found
R2682 T9472 T9473 compound Bleeding,time
R2683 T9473 T9474 nsubj time,was
R2684 T9475 T9474 neg not,was
R2685 T9476 T9474 acomp different,was
R2686 T9477 T9474 prep in,was
R2687 T9478 T9479 compound A,J
R2688 T9479 T9481 compound J,mice
R2689 T9480 T9479 punct /,J
R2690 T9481 T9477 pobj mice,in
R2691 T9482 T9474 prep compared,was
R2692 T9483 T9482 prep to,compared
R2693 T9484 T9485 compound B6,mice
R2694 T9485 T9483 pobj mice,to
R2695 T9486 T9487 punct (,2A
R2696 T9487 T9474 parataxis 2A,was
R2697 T9488 T9487 compound Figure,2A
R2698 T9489 T9487 punct ),2A
R2699 T9490 T9474 punct .,was
R2700 T9492 T9493 prep In,tested
R2701 T9494 T9492 pobj order,In
R2702 T9495 T9496 aux to,determine
R2703 T9496 T9494 acl determine,order
R2704 T9497 T9498 mark if,altered
R2705 T9498 T9496 ccomp altered,determine
R2706 T9499 T9500 amod specific,pathways
R2707 T9500 T9498 nsubjpass pathways,altered
R2708 T9501 T9498 auxpass were,altered
R2709 T9502 T9498 prep in,altered
R2710 T9503 T9504 det the,strains
R2711 T9504 T9502 pobj strains,in
R2712 T9505 T9504 nmod B6,strains
R2713 T9506 T9505 cc and,B6
R2714 T9507 T9508 compound A,J
R2715 T9508 T9505 conj J,B6
R2716 T9509 T9508 punct /,J
R2717 T9510 T9493 punct ", ",tested
R2718 T9511 T9493 nsubjpass mice,tested
R2719 T9512 T9511 prep with,mice
R2720 T9513 T9514 amod known,alterations
R2721 T9514 T9512 pobj alterations,with
R2722 T9515 T9514 prep in,alterations
R2723 T9516 T9515 pobj hemostasis,in
R2724 T9517 T9511 punct ", ",mice
R2725 T9518 T9519 compound Lepob,mice
R2726 T9519 T9511 appos mice,mice
R2727 T9520 T9511 punct ", ",mice
R2728 T9521 T9511 cc or,mice
R2729 T9522 T9511 conj thrombosis,mice
R2730 T9523 T9522 punct ", ",thrombosis
R2731 T9524 T9525 nmod Plg,mice
R2732 T9525 T9522 appos mice,thrombosis
R2733 T9526 T9524 punct -,Plg
R2734 T9527 T9524 punct /,Plg
R2735 T9528 T9524 punct -,Plg
R2736 T9529 T9524 cc and,Plg
R2737 T9530 T9524 conj PAI,Plg
R2738 T9531 T9530 punct -,PAI
R2739 T9532 T9530 punct /,PAI
R2740 T9533 T9530 punct -,PAI
R2741 T9534 T9493 punct ", ",tested
R2742 T9535 T9493 auxpass were,tested
R2743 T9536 T9493 advmod also,tested
R2744 T9537 T9493 punct .,tested
R2745 T9539 T9540 det The,mice
R2746 T9540 T9542 nsubj mice,have
R2747 T9541 T9540 compound Lepob,mice
R2748 T9543 T9544 amod impaired,aggregation
R2749 T9544 T9542 dobj aggregation,have
R2750 T9545 T9544 compound platelet,aggregation
R2751 T9546 T9547 punct [,26
R2752 T9547 T9542 parataxis 26,have
R2753 T9548 T9547 punct ],26
R2754 T9549 T9542 cc and,have
R2755 T9550 T9551 auxpass were,evaluated
R2756 T9551 T9542 conj evaluated,have
R2757 T9552 T9551 prep as,evaluated
R2758 T9553 T9554 det a,reference
R2759 T9554 T9552 pobj reference,as
R2760 T9555 T9554 prep for,reference
R2761 T9556 T9557 compound platelet,function
R2762 T9557 T9555 pobj function,for
R2763 T9558 T9542 punct .,have
R2764 T9560 T9561 prep In,was
R2765 T9562 T9563 det the,mice
R2766 T9563 T9560 pobj mice,In
R2767 T9564 T9563 compound Lepob,mice
R2768 T9565 T9566 punct (,2A
R2769 T9566 T9563 parataxis 2A,mice
R2770 T9567 T9566 compound Figure,2A
R2771 T9568 T9566 punct ),2A
R2772 T9569 T9561 expl there,was
R2773 T9570 T9571 advmod nearly,increase
R2774 T9571 T9561 attr increase,was
R2775 T9572 T9571 det a,increase
R2776 T9573 T9571 advmod 10-fold,increase
R2777 T9574 T9571 prep in,increase
R2778 T9575 T9576 compound bleeding,time
R2779 T9576 T9574 pobj time,in
R2780 T9577 T9571 prep compared,increase
R2781 T9578 T9577 prep to,compared
R2782 T9579 T9580 compound B6,mice
R2783 T9580 T9578 pobj mice,to
R2784 T9581 T9561 punct .,was
R2785 T9583 T9584 compound Bleeding,time
R2786 T9584 T9585 nsubjpass time,increased
R2787 T9586 T9585 auxpass was,increased
R2788 T9587 T9585 advmod also,increased
R2789 T9588 T9585 advmod significantly,increased
R2790 T9589 T9590 punct (,0.0001
R2791 T9590 T9588 parataxis 0.0001,significantly
R2792 T9591 T9590 nsubj P,0.0001
R2793 T9592 T9590 punct =,0.0001
R2794 T9593 T9590 punct ),0.0001
R2795 T9594 T9585 prep by,increased
R2796 T9595 T9596 nummod 66,%
R2797 T9596 T9594 pobj %,by
R2798 T9597 T9585 prep in,increased
R2799 T9598 T9599 det the,mice
R2800 T9599 T9597 pobj mice,in
R2801 T9600 T9599 nmod Plg,mice
R2802 T9601 T9600 punct -,Plg
R2803 T9602 T9600 punct /,Plg
R2804 T9603 T9600 punct -,Plg
R2805 T9604 T9585 prep compared,increased
R2806 T9605 T9604 prep to,compared
R2807 T9606 T9607 compound WT,littermates
R2808 T9607 T9605 pobj littermates,to
R2809 T9608 T9607 compound mice,littermates
R2810 T9609 T9585 punct .,increased
R2811 T9611 T9612 compound Bleeding,time
R2812 T9612 T9613 nsubj time,was
R2813 T9614 T9613 neg not,was
R2814 T9615 T9613 acomp different,was
R2815 T9616 T9613 prep in,was
R2816 T9617 T9618 nmod PAI,mice
R2817 T9618 T9616 pobj mice,in
R2818 T9619 T9617 punct -,PAI
R2819 T9620 T9617 nummod 1,PAI
R2820 T9621 T9617 punct -,PAI
R2821 T9622 T9617 punct /,PAI
R2822 T9623 T9617 punct -,PAI
R2823 T9624 T9613 prep compared,was
R2824 T9625 T9624 prep to,compared
R2825 T9626 T9627 compound B6,mice
R2826 T9627 T9625 pobj mice,to
R2827 T9628 T9613 punct .,was
R2828 T9630 T9631 prep In,was
R2829 T9632 T9630 pobj contrast,In
R2830 T9633 T9632 prep to,contrast
R2831 T9634 T9635 det the,mice
R2832 T9635 T9633 pobj mice,to
R2833 T9636 T9635 compound Lepob,mice
R2834 T9637 T9635 prep with,mice
R2835 T9638 T9639 det a,defect
R2836 T9639 T9637 pobj defect,with
R2837 T9640 T9639 compound platelet,defect
R2838 T9641 T9639 cc and,defect
R2839 T9642 T9643 advmod 10-fold,increase
R2840 T9643 T9639 conj increase,defect
R2841 T9644 T9643 prep in,increase
R2842 T9645 T9646 compound bleeding,time
R2843 T9646 T9644 pobj time,in
R2844 T9647 T9631 punct ", ",was
R2845 T9648 T9631 expl there,was
R2846 T9649 T9650 det no,difference
R2847 T9650 T9631 attr difference,was
R2848 T9651 T9650 prep in,difference
R2849 T9652 T9653 det the,time
R2850 T9653 T9651 pobj time,in
R2851 T9654 T9653 compound bleeding,time
R2852 T9655 T9653 prep between,time
R2853 T9656 T9657 nmod B6,mice
R2854 T9657 T9655 pobj mice,between
R2855 T9658 T9656 cc and,B6
R2856 T9659 T9660 compound A,J
R2857 T9660 T9656 conj J,B6
R2858 T9661 T9660 punct /,J
R2859 T9662 T9631 cc and,was
R2860 T9663 T9631 conj suggested,was
R2861 T9664 T9665 compound platelet,aggregation
R2862 T9665 T9666 nsubjpass aggregation,altered
R2863 T9666 T9663 advcl altered,suggested
R2864 T9667 T9666 auxpass is,altered
R2865 T9668 T9666 neg not,altered
R2866 T9669 T9666 prep in,altered
R2867 T9670 T9671 det these,strains
R2868 T9671 T9669 pobj strains,in
R2869 T9672 T9671 nummod two,strains
R2870 T9673 T9631 punct .,was
R2871 T9675 T9676 compound Rebleeding,time
R2872 T9676 T9677 nsubjpass time,measured
R2873 T9678 T9676 punct ", ",time
R2874 T9679 T9680 det an,indicator
R2875 T9680 T9676 appos indicator,time
R2876 T9681 T9680 prep of,indicator
R2877 T9682 T9683 compound thrombus,stability
R2878 T9683 T9681 pobj stability,of
R2879 T9684 T9677 punct ", ",measured
R2880 T9685 T9677 auxpass was,measured
R2881 T9686 T9677 prep as,measured
R2882 T9687 T9688 det the,time
R2883 T9688 T9686 pobj time,as
R2884 T9689 T9688 prep between,time
R2885 T9690 T9691 det the,cessation
R2886 T9691 T9689 pobj cessation,between
R2887 T9692 T9691 prep of,cessation
R2888 T9693 T9692 pobj bleeding,of
R2889 T9694 T9691 cc and,cessation
R2890 T9695 T9696 det the,start
R2891 T9696 T9691 conj start,cessation
R2892 T9697 T9696 prep of,start
R2893 T9698 T9699 det the,bleeding
R2894 T9699 T9697 pobj bleeding,of
R2895 T9700 T9699 amod second,bleeding
R2896 T9701 T9702 punct (,2B
R2897 T9702 T9677 parataxis 2B,measured
R2898 T9703 T9702 compound Figure,2B
R2899 T9704 T9702 punct ),2B
R2900 T9705 T9677 punct .,measured
R2901 T9707 T9708 compound Rebleeding,times
R2902 T9708 T9709 nsubj times,were
R2903 T9710 T9711 advmod significantly,higher
R2904 T9711 T9709 acomp higher,were
R2905 T9712 T9709 prep in,were
R2906 T9713 T9714 nmod A,J
R2907 T9714 T9716 nmod J,mice
R2908 T9715 T9714 punct /,J
R2909 T9716 T9712 pobj mice,in
R2910 T9717 T9718 punct (,2.6-fold
R2911 T9718 T9714 parataxis 2.6-fold,J
R2912 T9719 T9718 punct ", ",2.6-fold
R2913 T9720 T9721 nsubj P,0.001
R2914 T9721 T9718 ccomp 0.001,2.6-fold
R2915 T9722 T9721 punct <,0.001
R2916 T9723 T9718 punct ),2.6-fold
R2917 T9724 T9709 prep than,were
R2918 T9725 T9726 det the,mice
R2919 T9726 T9724 pobj mice,than
R2920 T9727 T9726 compound B6,mice
R2921 T9728 T9709 punct .,were
R2922 T9730 T9731 prep In,was
R2923 T9732 T9730 pobj contrast,In
R2924 T9733 T9731 punct ", ",was
R2925 T9734 T9735 det the,time
R2926 T9735 T9731 nsubj time,was
R2927 T9736 T9735 compound rebleeding,time
R2928 T9737 T9738 advmod nearly,8.5-fold
R2929 T9738 T9739 advmod 8.5-fold,less
R2930 T9739 T9731 acomp less,was
R2931 T9740 T9731 prep in,was
R2932 T9741 T9742 det the,mice
R2933 T9742 T9740 pobj mice,in
R2934 T9743 T9742 compound Lepob,mice
R2935 T9744 T9731 prep than,was
R2936 T9745 T9746 det the,mice
R2937 T9746 T9744 pobj mice,than
R2938 T9747 T9746 compound B6,mice
R2939 T9748 T9731 punct .,was
R2940 T9750 T9751 aux To,determine
R2941 T9751 T9752 advcl determine,tested
R2942 T9753 T9754 advmod how,affect
R2943 T9754 T9751 ccomp affect,determine
R2944 T9755 T9754 nsubj alterations,affect
R2945 T9756 T9755 prep in,alterations
R2946 T9757 T9758 det the,system
R2947 T9758 T9756 pobj system,in
R2948 T9759 T9758 amod fibrinolytic,system
R2949 T9760 T9754 aux may,affect
R2950 T9761 T9762 compound rebleeding,time
R2951 T9762 T9754 dobj time,affect
R2952 T9763 T9752 punct ", ",tested
R2953 T9764 T9765 nmod Plg,mice
R2954 T9765 T9752 nsubjpass mice,tested
R2955 T9766 T9764 punct -,Plg
R2956 T9767 T9764 punct /,Plg
R2957 T9768 T9764 punct -,Plg
R2958 T9769 T9764 cc and,Plg
R2959 T9770 T9764 conj PAI,Plg
R2960 T9771 T9770 punct -,PAI
R2961 T9772 T9770 nummod 1,PAI
R2962 T9773 T9770 punct -,PAI
R2963 T9774 T9770 punct /,PAI
R2964 T9775 T9770 punct -,PAI
R2965 T9776 T9752 auxpass were,tested
R2966 T9777 T9752 advmod also,tested
R2967 T9778 T9779 punct (,2B
R2968 T9779 T9752 parataxis 2B,tested
R2969 T9780 T9779 compound Figure,2B
R2970 T9781 T9779 punct ),2B
R2971 T9782 T9752 punct .,tested
R2972 T9784 T9785 amod Rebleeding,time
R2973 T9785 T9786 nsubj time,was
R2974 T9787 T9786 neg not,was
R2975 T9788 T9786 acomp different,was
R2976 T9789 T9786 prep in,was
R2977 T9790 T9791 nmod Plg,mice
R2978 T9791 T9789 pobj mice,in
R2979 T9792 T9790 punct -,Plg
R2980 T9793 T9790 punct /,Plg
R2981 T9794 T9790 punct -,Plg
R2982 T9795 T9786 prep compared,was
R2983 T9796 T9795 prep to,compared
R2984 T9797 T9798 compound WT,littermates
R2985 T9798 T9796 pobj littermates,to
R2986 T9799 T9786 punct ", ",was
R2987 T9800 T9786 cc but,was
R2988 T9801 T9802 nmod PAI,mice
R2989 T9802 T9808 nsubj mice,had
R2990 T9803 T9801 punct -,PAI
R2991 T9804 T9801 nummod 1,PAI
R2992 T9805 T9801 punct -,PAI
R2993 T9806 T9801 punct /,PAI
R2994 T9807 T9801 punct -,PAI
R2995 T9808 T9786 conj had,was
R2996 T9809 T9810 det a,time
R2997 T9810 T9808 dobj time,had
R2998 T9811 T9812 advmod significantly,reduced
R2999 T9812 T9810 amod reduced,time
R3000 T9813 T9814 punct (,0.05
R3001 T9814 T9811 parataxis 0.05,significantly
R3002 T9815 T9814 nsubj P,0.05
R3003 T9816 T9814 punct <,0.05
R3004 T9817 T9814 punct ),0.05
R3005 T9818 T9810 compound rebleeding,time
R3006 T9819 T9810 punct ", ",time
R3007 T9820 T9821 dep which,was
R3008 T9821 T9810 relcl was,time
R3009 T9822 T9823 advmod 1.8-fold,lower
R3010 T9823 T9821 acomp lower,was
R3011 T9824 T9823 prep than,lower
R3012 T9825 T9824 prep for,than
R3013 T9826 T9827 det the,mice
R3014 T9827 T9825 pobj mice,for
R3015 T9828 T9827 compound B6,mice
R3016 T9829 T9808 punct .,had
R3017 T9831 T9832 mark Although,result
R3018 T9832 T9838 advcl result,resulted
R3019 T9833 T9834 det a,deficiency
R3020 T9834 T9832 nsubj deficiency,result
R3021 T9835 T9834 compound Plg,deficiency
R3022 T9836 T9832 aux did,result
R3023 T9837 T9832 neg not,result
R3024 T9839 T9832 prep in,result
R3025 T9840 T9841 det a,time
R3026 T9841 T9839 pobj time,in
R3027 T9842 T9841 amod prolonged,time
R3028 T9843 T9841 compound rebleeding,time
R3029 T9844 T9845 mark as,anticipated
R3030 T9845 T9832 advcl anticipated,result
R3031 T9846 T9838 punct ", ",resulted
R3032 T9847 T9848 det a,deficiency
R3033 T9848 T9838 nsubj deficiency,resulted
R3034 T9849 T9848 nmod PAI,deficiency
R3035 T9850 T9849 punct -,PAI
R3036 T9851 T9849 nummod 1,PAI
R3037 T9852 T9838 prep in,resulted
R3038 T9853 T9854 det a,time
R3039 T9854 T9852 pobj time,in
R3040 T9855 T9854 amod shortened,time
R3041 T9856 T9838 punct .,resulted
R3042 T9858 T9859 det The,time
R3043 T9859 T9863 nsubj time,suggest
R3044 T9860 T9861 advmod markedly,increased
R3045 T9861 T9859 amod increased,time
R3046 T9862 T9859 compound rebleeding,time
R3047 T9864 T9859 prep in,time
R3048 T9865 T9866 det the,J
R3049 T9866 T9864 pobj J,in
R3050 T9867 T9866 compound A,J
R3051 T9868 T9866 punct /,J
R3052 T9869 T9863 aux may,suggest
R3053 T9870 T9863 dobj differences,suggest
R3054 T9871 T9870 prep in,differences
R3055 T9872 T9873 det the,regulation
R3056 T9873 T9871 pobj regulation,in
R3057 T9874 T9873 prep of,regulation
R3058 T9875 T9876 det the,network
R3059 T9876 T9874 pobj network,of
R3060 T9877 T9876 compound Plg,network
R3061 T9878 T9863 punct .,suggest
R3068 T10215 T10216 det No,difference
R3069 T10217 T10216 prep in,difference
R3070 T10218 T10219 compound blood,coagulation
R3071 T10219 T10217 pobj coagulation,in
R3072 T10220 T10216 prep between,difference
R3073 T10221 T10222 nmod B6,mice
R3074 T10222 T10220 pobj mice,between
R3075 T10223 T10221 cc and,B6
R3076 T10224 T10225 compound A,J
R3077 T10225 T10221 conj J,B6
R3078 T10226 T10225 punct /,J
R3079 T10228 T10229 aux To,determine
R3080 T10229 T10230 advcl determine,measured
R3081 T10231 T10232 mark if,were
R3082 T10232 T10229 ccomp were,determine
R3083 T10233 T10232 nsubj differences,were
R3084 T10234 T10233 prep in,differences
R3085 T10235 T10234 pobj coagulation,in
R3086 T10236 T10237 amod contributing,factors
R3087 T10237 T10232 attr factors,were
R3088 T10238 T10237 prep to,factors
R3089 T10239 T10240 det the,results
R3090 T10240 T10238 pobj results,to
R3091 T10241 T10240 nmod bleeding,results
R3092 T10242 T10241 cc and,bleeding
R3093 T10243 T10241 conj rebleeding,bleeding
R3094 T10244 T10230 punct ", ",measured
R3095 T10245 T10246 compound prothrombin,time
R3096 T10246 T10230 nsubjpass time,measured
R3097 T10247 T10246 punct (,time
R3098 T10248 T10246 appos PT,time
R3099 T10249 T10246 punct ),time
R3100 T10250 T10246 cc and,time
R3101 T10251 T10252 amod activated,time
R3102 T10252 T10246 conj time,time
R3103 T10253 T10252 amod partial,time
R3104 T10254 T10252 compound thromboplastin,time
R3105 T10255 T10252 punct (,time
R3106 T10256 T10252 appos aPTT,time
R3107 T10257 T10230 punct ),measured
R3108 T10258 T10230 auxpass were,measured
R3109 T10259 T10230 punct .,measured
R3110 T10261 T10262 nsubj PT,is
R3111 T10263 T10264 det a,measurement
R3112 T10264 T10262 attr measurement,is
R3113 T10265 T10264 prep of,measurement
R3114 T10266 T10267 det the,pathway
R3115 T10267 T10265 pobj pathway,of
R3116 T10268 T10267 amod extrinsic,pathway
R3117 T10269 T10267 compound coagulation,pathway
R3118 T10270 T10267 punct (,pathway
R3119 T10271 T10267 appos activation,pathway
R3120 T10272 T10271 prep of,activation
R3121 T10273 T10272 pobj Factor,of
R3122 T10274 T10273 nummod VII,Factor
R3123 T10275 T10271 prep by,activation
R3124 T10276 T10277 compound tissue,factor
R3125 T10277 T10275 pobj factor,by
R3126 T10278 T10262 punct ),is
R3127 T10279 T10280 mark while,is
R3128 T10280 T10262 advcl is,is
R3129 T10281 T10280 nsubj aPTT,is
R3130 T10282 T10283 det a,measurement
R3131 T10283 T10280 attr measurement,is
R3132 T10284 T10283 prep of,measurement
R3133 T10285 T10286 det the,pathway
R3134 T10286 T10284 pobj pathway,of
R3135 T10287 T10286 amod intrinsic,pathway
R3136 T10288 T10286 punct (,pathway
R3137 T10289 T10286 appos activation,pathway
R3138 T10290 T10289 prep of,activation
R3139 T10291 T10292 nmod Factors,XII
R3140 T10292 T10290 pobj XII,of
R3141 T10293 T10292 punct ", ",XII
R3142 T10294 T10292 conj XI,XII
R3143 T10295 T10294 punct ", ",XI
R3144 T10296 T10294 conj IX,XI
R3145 T10297 T10296 cc and,IX
R3146 T10298 T10296 conj VIII,IX
R3147 T10299 T10262 punct ),is
R3148 T10300 T10262 punct .,is
R3149 T10302 T10303 det The,products
R3150 T10303 T10304 nsubj products,activate
R3151 T10305 T10303 prep of,products
R3152 T10306 T10307 det both,pathways
R3153 T10307 T10305 pobj pathways,of
R3154 T10308 T10304 dobj Factor,activate
R3155 T10309 T10308 nummod X,Factor
R3156 T10310 T10308 punct ", ",Factor
R3157 T10311 T10312 dep which,initiates
R3158 T10312 T10308 relcl initiates,Factor
R3159 T10313 T10314 det the,pathway
R3160 T10314 T10312 dobj pathway,initiates
R3161 T10315 T10314 amod common,pathway
R3162 T10316 T10314 acl leading,pathway
R3163 T10317 T10316 prep to,leading
R3164 T10318 T10319 compound thrombin,generation
R3165 T10319 T10317 pobj generation,to
R3166 T10320 T10319 cc and,generation
R3167 T10321 T10322 compound fibrin,clot
R3168 T10322 T10323 compound clot,formation
R3169 T10323 T10319 conj formation,generation
R3170 T10324 T10304 punct .,activate
R3171 T10326 T10327 nsubjpass PT,measured
R3172 T10328 T10326 cc and,PT
R3173 T10329 T10326 conj aPTT,PT
R3174 T10330 T10327 auxpass were,measured
R3175 T10331 T10327 prep in,measured
R3176 T10332 T10333 det the,mice
R3177 T10333 T10331 pobj mice,in
R3178 T10334 T10333 nmod B6,mice
R3179 T10335 T10334 cc and,B6
R3180 T10336 T10337 compound A,J
R3181 T10337 T10334 conj J,B6
R3182 T10338 T10337 punct /,J
R3183 T10339 T10327 cc and,measured
R3184 T10340 T10341 nsubj values,were
R3185 T10341 T10327 conj were,measured
R3186 T10342 T10341 neg not,were
R3187 T10343 T10341 acomp different,were
R3188 T10344 T10343 prep between,different
R3189 T10345 T10346 det the,strains
R3190 T10346 T10344 pobj strains,between
R3191 T10347 T10346 nummod two,strains
R3192 T10348 T10346 compound mouse,strains
R3193 T10349 T10350 punct (,Table
R3194 T10350 T10341 parataxis Table,were
R3195 T10351 T10350 nummod 2,Table
R3196 T10352 T10350 punct ),Table
R3197 T10353 T10341 punct .,were
R3198 T10355 T10356 det These,results
R3199 T10356 T10357 nsubj results,suggest
R3200 T10358 T10359 mark that,is
R3201 T10359 T10357 ccomp is,suggest
R3202 T10360 T10361 det the,pathway
R3203 T10361 T10359 nsubj pathway,is
R3204 T10362 T10361 compound coagulation,pathway
R3205 T10363 T10359 neg not,is
R3206 T10364 T10359 acomp different,is
R3207 T10365 T10359 prep in,is
R3208 T10366 T10367 det the,strains
R3209 T10367 T10365 pobj strains,in
R3210 T10368 T10367 nummod two,strains
R3211 T10369 T10367 amod inbred,strains
R3212 T10370 T10357 punct .,suggest
R3213 T10951 T10952 nsubj Plg,higher
R3214 T10953 T10951 cc and,Plg
R3215 T10954 T10951 conj PAI,Plg
R3216 T10955 T10954 punct -,PAI
R3217 T10956 T10954 nummod 1,PAI
R3218 T10957 T10952 prep in,higher
R3219 T10958 T10959 compound A,J
R3220 T10959 T10957 pobj J,in
R3221 T10960 T10959 punct /,J
R3222 T10961 T10952 prep than,higher
R3223 T10962 T10963 compound B6,mice
R3224 T10963 T10961 pobj mice,than
R3225 T10965 T10966 compound Plg,concentration
R3226 T10966 T10967 nsubj concentration,was
R3227 T10968 T10969 nummod 34,%
R3228 T10969 T10970 npadvmod %,higher
R3229 T10970 T10967 acomp higher,was
R3230 T10971 T10967 prep in,was
R3231 T10972 T10973 det the,mice
R3232 T10973 T10971 pobj mice,in
R3233 T10974 T10975 compound A,J
R3234 T10975 T10973 compound J,mice
R3235 T10976 T10975 punct /,J
R3236 T10977 T10967 prep than,was
R3237 T10978 T10977 prep in,than
R3238 T10979 T10980 compound B6,mice
R3239 T10980 T10978 pobj mice,in
R3240 T10981 T10967 punct .,was
R3241 T10983 T10984 prep In,increased
R3242 T10985 T10983 pobj addition,In
R3243 T10986 T10984 punct ", ",increased
R3244 T10987 T10988 amod fibrinolytic,activity
R3245 T10988 T10984 nsubjpass activity,increased
R3246 T10989 T10988 punct ", ",activity
R3247 T10990 T10991 nmod PAI,activity
R3248 T10991 T10988 conj activity,activity
R3249 T10992 T10990 punct -,PAI
R3250 T10993 T10990 nummod 1,PAI
R3251 T10994 T10991 punct ", ",activity
R3252 T10995 T10991 cc and,activity
R3253 T10996 T10997 compound α2,anitplasmin
R3254 T10997 T10991 conj anitplasmin,activity
R3255 T10998 T10997 punct -,anitplasmin
R3256 T10999 T10984 auxpass were,increased
R3257 T11000 T10984 advmod also,increased
R3258 T11001 T10984 prep in,increased
R3259 T11002 T11003 det the,mice
R3260 T11003 T11001 pobj mice,in
R3261 T11004 T11005 nmod A,J
R3262 T11005 T11003 compound J,mice
R3263 T11006 T11005 punct /,J
R3264 T11007 T11008 advmod when,compared
R3265 T11008 T10984 advcl compared,increased
R3266 T11009 T11008 prep to,compared
R3267 T11010 T11011 det the,mice
R3268 T11011 T11009 pobj mice,to
R3269 T11012 T11011 compound B6,mice
R3270 T11013 T11014 punct (,Table
R3271 T11014 T10984 parataxis Table,increased
R3272 T11015 T11014 nummod 2,Table
R3273 T11016 T11014 punct ),Table
R3274 T11017 T10984 punct .,increased
R3275 T11019 T11020 det The,consequences
R3276 T11020 T11022 nsubj consequences,are
R3277 T11021 T11020 amod functional,consequences
R3278 T11023 T11020 prep of,consequences
R3279 T11024 T11025 det these,differences
R3280 T11025 T11023 pobj differences,of
R3281 T11026 T11022 neg not,are
R3282 T11027 T11022 acomp clear,are
R3283 T11028 T11022 punct ", ",are
R3284 T11029 T11030 mark since,is
R3285 T11030 T11022 advcl is,are
R3286 T11031 T11030 nsubj fibrinogen,is
R3287 T11032 T11030 advmod also,is
R3288 T11033 T11030 acomp higher,is
R3289 T11034 T11030 prep in,is
R3290 T11035 T11036 det the,mice
R3291 T11036 T11034 pobj mice,in
R3292 T11037 T11038 compound A,J
R3293 T11038 T11036 compound J,mice
R3294 T11039 T11038 punct /,J
R3295 T11040 T11022 punct .,are
R3296 T11042 T11043 aux To,determine
R3297 T11043 T11044 advcl determine,subjected
R3298 T11045 T11046 mark whether,were
R3299 T11046 T11043 ccomp were,determine
R3300 T11047 T11046 expl there,were
R3301 T11048 T11049 compound protein,structure
R3302 T11049 T11050 compound structure,changes
R3303 T11050 T11046 attr changes,were
R3304 T11051 T11050 prep of,changes
R3305 T11052 T11051 pobj Plg,of
R3306 T11053 T11050 prep from,changes
R3307 T11054 T11055 det the,mice
R3308 T11055 T11053 pobj mice,from
R3309 T11056 T11057 compound A,J
R3310 T11057 T11055 compound J,mice
R3311 T11058 T11057 punct /,J
R3312 T11059 T11044 punct ", ",subjected
R3313 T11060 T11044 nsubjpass plasma,subjected
R3314 T11061 T11060 prep from,plasma
R3315 T11062 T11063 det the,B6
R3316 T11063 T11061 pobj B6,from
R3317 T11064 T11063 cc and,B6
R3318 T11065 T11066 det the,J
R3319 T11066 T11069 compound J,mice
R3320 T11067 T11066 compound A,J
R3321 T11068 T11066 punct /,J
R3322 T11069 T11063 conj mice,B6
R3323 T11070 T11044 auxpass were,subjected
R3324 T11071 T11044 prep to,subjected
R3325 T11072 T11071 pobj electrophoresis,to
R3326 T11073 T11044 prep under,subjected
R3327 T11074 T11075 amod reduced,conditions
R3328 T11075 T11073 pobj conditions,under
R3329 T11076 T11074 punct ", ",reduced
R3330 T11077 T11074 conj non-reduced,reduced
R3331 T11078 T11077 punct ", ",non-reduced
R3332 T11079 T11077 cc and,non-reduced
R3333 T11080 T11077 conj non-denaturing,non-reduced
R3334 T11081 T11044 punct .,subjected
R3335 T11083 T11084 det No,difference
R3336 T11084 T11085 nsubjpass difference,observed
R3337 T11086 T11084 prep in,difference
R3338 T11087 T11086 pobj migration,in
R3339 T11088 T11084 prep for,difference
R3340 T11089 T11090 amod immunostained,Plg
R3341 T11090 T11088 pobj Plg,for
R3342 T11091 T11084 prep under,difference
R3343 T11092 T11093 det these,conditions
R3344 T11093 T11091 pobj conditions,under
R3345 T11094 T11085 auxpass was,observed
R3346 T11095 T11096 punct (,shown
R3347 T11096 T11085 parataxis shown,observed
R3348 T11097 T11096 nsubj data,shown
R3349 T11098 T11096 neg not,shown
R3350 T11099 T11096 punct ),shown
R3351 T11100 T11085 punct .,observed
R3352 T11102 T11103 det The,density
R3353 T11103 T11104 nsubjpass density,compared
R3354 T11105 T11103 prep of,density
R3355 T11106 T11107 det the,blot
R3356 T11107 T11105 pobj blot,of
R3357 T11108 T11107 compound Western,blot
R3358 T11109 T11107 prep from,blot
R3359 T11110 T11111 compound SDS,PAGE
R3360 T11111 T11109 pobj PAGE,from
R3361 T11112 T11111 punct -,PAGE
R3362 T11113 T11103 prep under,density
R3363 T11114 T11115 compound reducing,conditions
R3364 T11115 T11113 pobj conditions,under
R3365 T11116 T11115 prep of,conditions
R3366 T11117 T11116 pobj plasma,of
R3367 T11118 T11117 prep of,plasma
R3368 T11119 T11120 amod varying,volumes
R3369 T11120 T11118 pobj volumes,of
R3370 T11121 T11117 prep from,plasma
R3371 T11122 T11123 nmod B6,mice
R3372 T11123 T11121 pobj mice,from
R3373 T11124 T11122 cc and,B6
R3374 T11125 T11126 compound A,J
R3375 T11126 T11122 conj J,B6
R3376 T11127 T11126 punct /,J
R3377 T11128 T11104 auxpass was,compared
R3378 T11129 T11104 cc and,compared
R3379 T11130 T11131 det the,density
R3380 T11131 T11132 nsubj density,was
R3381 T11132 T11104 conj was,compared
R3382 T11133 T11131 prep of,density
R3383 T11134 T11135 det the,bands
R3384 T11135 T11133 pobj bands,of
R3385 T11136 T11137 nummod 56,%
R3386 T11137 T11138 npadvmod %,higher
R3387 T11138 T11132 acomp higher,was
R3388 T11139 T11132 prep in,was
R3389 T11140 T11141 det the,J
R3390 T11141 T11139 pobj J,in
R3391 T11142 T11141 compound A,J
R3392 T11143 T11141 punct /,J
R3393 T11144 T11132 prep than,was
R3394 T11145 T11146 det the,B6
R3395 T11146 T11144 pobj B6,than
R3396 T11147 T11132 dobj mice,was
R3397 T11148 T11149 punct (,tested
R3398 T11149 T11132 parataxis tested,was
R3399 T11150 T11151 nummod six,mice
R3400 T11151 T11149 nsubjpass mice,tested
R3401 T11152 T11151 amod individual,mice
R3402 T11153 T11149 auxpass were,tested
R3403 T11154 T11149 prep on,tested
R3404 T11155 T11156 advmod at,two
R3405 T11156 T11158 nummod two,occasions
R3406 T11157 T11156 advmod least,two
R3407 T11158 T11154 pobj occasions,on
R3408 T11159 T11149 punct ),tested
R3409 T11160 T11132 prep from,was
R3410 T11161 T11162 det the,amount
R3411 T11162 T11160 pobj amount,from
R3412 T11163 T11162 amod same,amount
R3413 T11164 T11162 prep of,amount
R3414 T11165 T11164 pobj plasma,of
R3415 T11166 T11167 punct (,1B
R3416 T11167 T11132 parataxis 1B,was
R3417 T11168 T11167 compound Fig.,1B
R3418 T11169 T11167 punct ),1B
R3419 T11170 T11132 punct .,was
R3420 T11172 T11173 advmod Thus,was
R3421 T11174 T11173 punct ", ",was
R3422 T11175 T11176 det the,concentration
R3423 T11176 T11173 nsubj concentration,was
R3424 T11177 T11176 prep of,concentration
R3425 T11178 T11177 pobj Plg,of
R3426 T11179 T11176 prep in,concentration
R3427 T11180 T11179 pobj plasma,in
R3428 T11181 T11180 prep from,plasma
R3429 T11182 T11183 det the,mice
R3430 T11183 T11181 pobj mice,from
R3431 T11184 T11185 compound A,J
R3432 T11185 T11183 compound J,mice
R3433 T11186 T11185 punct /,J
R3434 T11187 T11173 acomp higher,was
R3435 T11188 T11187 prep than,higher
R3436 T11189 T11188 pobj plasma,than
R3437 T11190 T11189 prep from,plasma
R3438 T11191 T11192 det the,mice
R3439 T11192 T11190 pobj mice,from
R3440 T11193 T11192 compound B6,mice
R3441 T11194 T11195 mark as,determined
R3442 T11195 T11173 advcl determined,was
R3443 T11196 T11195 prep by,determined
R3444 T11197 T11198 nummod two,methods
R3445 T11198 T11196 pobj methods,by
R3446 T11199 T11173 cc and,was
R3447 T11200 T11201 det no,difference
R3448 T11201 T11202 nsubjpass difference,observed
R3449 T11202 T11173 conj observed,was
R3450 T11203 T11201 prep in,difference
R3451 T11204 T11203 pobj migration,in
R3452 T11205 T11201 prep after,difference
R3453 T11206 T11205 pobj electrophoresis,after
R3454 T11207 T11202 auxpass was,observed
R3455 T11208 T11202 punct ", ",observed
R3456 T11209 T11202 advcl suggesting,observed
R3457 T11210 T11211 det no,changes
R3458 T11211 T11209 dobj changes,suggesting
R3459 T11212 T11211 amod marked,changes
R3460 T11213 T11211 prep in,changes
R3461 T11214 T11215 det the,structure
R3462 T11215 T11213 pobj structure,in
R3463 T11216 T11215 prep of,structure
R3464 T11217 T11216 pobj Plg,of
R3465 T11218 T11211 prep in,changes
R3466 T11219 T11220 det the,strains
R3467 T11220 T11218 pobj strains,in
R3468 T11221 T11220 nummod two,strains
R3469 T11222 T11220 compound mouse,strains
R3470 T11223 T11202 punct .,observed
R3471 T11637 T11638 compound Tail,morphology
R3472 T11639 T11638 prep in,morphology
R3473 T11640 T11639 pobj B6,in
R3474 T11641 T11640 cc and,B6
R3475 T11642 T11643 compound A,J
R3476 T11643 T11640 conj J,B6
R3477 T11644 T11643 punct /,J
R3478 T11646 T11647 det The,tails
R3479 T11647 T11648 nsubjpass tails,examined
R3480 T11649 T11647 prep of,tails
R3481 T11650 T11651 det the,mice
R3482 T11651 T11649 pobj mice,of
R3483 T11652 T11648 auxpass were,examined
R3484 T11653 T11648 prep for,examined
R3485 T11654 T11653 pobj differences,for
R3486 T11655 T11656 dep that,account
R3487 T11656 T11654 relcl account,differences
R3488 T11657 T11656 aux might,account
R3489 T11658 T11656 prep for,account
R3490 T11659 T11660 det the,variations
R3491 T11660 T11658 pobj variations,for
R3492 T11661 T11660 prep in,variations
R3493 T11662 T11663 det the,values
R3494 T11663 T11661 pobj values,in
R3495 T11664 T11663 nmod bleeding,values
R3496 T11665 T11664 cc and,bleeding
R3497 T11666 T11664 conj rebleeding,bleeding
R3498 T11667 T11648 punct .,examined
R3499 T11669 T11670 nsubjpass Sections,stained
R3500 T11671 T11669 prep of,Sections
R3501 T11672 T11673 det the,tail
R3502 T11673 T11671 pobj tail,of
R3503 T11674 T11673 prep from,tail
R3504 T11675 T11676 det the,mice
R3505 T11676 T11674 pobj mice,from
R3506 T11677 T11676 nmod B6,mice
R3507 T11678 T11677 cc and,B6
R3508 T11679 T11680 compound A,J
R3509 T11680 T11677 conj J,B6
R3510 T11681 T11680 punct /,J
R3511 T11682 T11670 auxpass were,stained
R3512 T11683 T11670 prep with,stained
R3513 T11684 T11685 compound Hematoxylin,Eosin
R3514 T11685 T11683 pobj Eosin,with
R3515 T11686 T11685 punct /,Eosin
R3516 T11687 T11685 cc or,Eosin
R3517 T11688 T11689 poss Masson,Trichrome
R3518 T11689 T11685 conj Trichrome,Eosin
R3519 T11690 T11688 case 's,Masson
R3520 T11691 T11670 cc and,stained
R3521 T11692 T11693 amod representative,sections
R3522 T11693 T11694 nsubjpass sections,shown
R3523 T11694 T11670 conj shown,stained
R3524 T11695 T11694 auxpass are,shown
R3525 T11696 T11694 prep in,shown
R3526 T11697 T11696 pobj Figure,in
R3527 T11698 T11697 nummod 3,Figure
R3528 T11699 T11694 punct .,shown
R3529 T11701 T11702 det No,differences
R3530 T11702 T11705 nsubjpass differences,observed
R3531 T11703 T11702 amod obvious,differences
R3532 T11704 T11702 amod qualitative,differences
R3533 T11706 T11705 auxpass were,observed
R3534 T11707 T11705 prep in,observed
R3535 T11708 T11709 compound hair,follicles
R3536 T11709 T11707 pobj follicles,in
R3537 T11710 T11709 punct ", ",follicles
R3538 T11711 T11712 amod sebaceous,glands
R3539 T11712 T11709 conj glands,follicles
R3540 T11713 T11712 punct ", ",glands
R3541 T11714 T11712 cc or,glands
R3542 T11715 T11716 compound center,bone
R3543 T11716 T11712 conj bone,glands
R3544 T11717 T11716 punct /,bone
R3545 T11718 T11716 appos cartilage,bone
R3546 T11719 T11705 prep in,observed
R3547 T11720 T11721 compound Hematoxylin,Eosin
R3548 T11721 T11723 npadvmod Eosin,stained
R3549 T11722 T11721 punct /,Eosin
R3550 T11723 T11728 amod stained,sections
R3551 T11724 T11725 punct (,3A
R3552 T11725 T11721 parataxis 3A,Eosin
R3553 T11726 T11725 compound Figure,3A
R3554 T11727 T11725 punct ),3A
R3555 T11728 T11719 pobj sections,in
R3556 T11729 T11705 punct .,observed
R3557 T11731 T11732 nsubjpass Sections,stained
R3558 T11733 T11731 prep of,Sections
R3559 T11734 T11735 det the,tails
R3560 T11735 T11733 pobj tails,of
R3561 T11736 T11732 auxpass were,stained
R3562 T11737 T11732 prep with,stained
R3563 T11738 T11739 poss Masson,Trichrome
R3564 T11739 T11737 pobj Trichrome,with
R3565 T11740 T11738 case 's,Masson
R3566 T11741 T11742 punct (,3B
R3567 T11742 T11739 parataxis 3B,Trichrome
R3568 T11743 T11742 compound Figure,3B
R3569 T11744 T11742 punct ),3B
R3570 T11745 T11746 dep that,detects
R3571 T11746 T11739 relcl detects,Trichrome
R3572 T11747 T11746 dobj collagen,detects
R3573 T11748 T11747 punct ", ",collagen
R3574 T11749 T11750 det the,substratum
R3575 T11750 T11747 appos substratum,collagen
R3576 T11751 T11750 amod major,substratum
R3577 T11752 T11750 nmod platelet,substratum
R3578 T11753 T11752 amod adhesive,platelet
R3579 T11754 T11750 prep for,substratum
R3580 T11755 T11754 pobj initiation,for
R3581 T11756 T11755 prep of,initiation
R3582 T11757 T11758 compound thrombus,formation
R3583 T11758 T11756 pobj formation,of
R3584 T11759 T11732 punct .,stained
R3585 T11761 T11762 compound Collagen,content
R3586 T11762 T11763 nsubjpass content,quantified
R3587 T11764 T11765 punct (,area
R3588 T11765 T11762 parataxis area,content
R3589 T11766 T11765 compound %,area
R3590 T11767 T11765 compound tail,area
R3591 T11768 T11765 punct ),area
R3592 T11769 T11763 auxpass was,quantified
R3593 T11770 T11771 punct (,3C
R3594 T11771 T11763 parataxis 3C,quantified
R3595 T11772 T11771 compound Figure,3C
R3596 T11773 T11771 punct ),3C
R3597 T11774 T11763 prep from,quantified
R3598 T11775 T11776 quantmod 3,4
R3599 T11776 T11778 nummod 4,sections
R3600 T11777 T11776 punct –,4
R3601 T11778 T11774 pobj sections,from
R3602 T11779 T11778 prep from,sections
R3603 T11780 T11781 quantmod 2,3
R3604 T11781 T11783 nummod 3,areas
R3605 T11782 T11781 punct –,3
R3606 T11783 T11779 pobj areas,from
R3607 T11784 T11785 punct /,mouse
R3608 T11785 T11783 prep mouse,areas
R3609 T11786 T11763 punct .,quantified
R3610 T11788 T11789 det The,amount
R3611 T11789 T11790 nsubj amount,was
R3612 T11791 T11789 prep of,amount
R3613 T11792 T11791 pobj collagen,of
R3614 T11793 T11790 acomp greater,was
R3615 T11794 T11790 prep in,was
R3616 T11795 T11796 det the,J
R3617 T11796 T11794 pobj J,in
R3618 T11797 T11796 compound A,J
R3619 T11798 T11796 punct /,J
R3620 T11799 T11790 prep than,was
R3621 T11800 T11801 det the,mice
R3622 T11801 T11799 pobj mice,than
R3623 T11802 T11801 compound B6,mice
R3624 T11803 T11804 punct (,0.05
R3625 T11804 T11790 parataxis 0.05,was
R3626 T11805 T11804 nsubj P,0.05
R3627 T11806 T11804 punct <,0.05
R3628 T11807 T11804 punct ),0.05
R3629 T11808 T11790 punct .,was
R3630 T11810 T11811 nsubjpass Collagen,increased
R3631 T11812 T11810 prep in,Collagen
R3632 T11813 T11812 pobj vessels,in
R3633 T11814 T11813 prep in,vessels
R3634 T11815 T11816 compound adipose,tissue
R3635 T11816 T11814 pobj tissue,in
R3636 T11817 T11816 prep in,tissue
R3637 T11818 T11819 det the,mice
R3638 T11819 T11817 pobj mice,in
R3639 T11820 T11821 compound A,J
R3640 T11821 T11819 compound J,mice
R3641 T11822 T11821 punct /,J
R3642 T11823 T11811 auxpass is,increased
R3643 T11824 T11811 advmod also,increased
R3644 T11825 T11811 prep compared,increased
R3645 T11826 T11825 prep to,compared
R3646 T11827 T11828 det the,mice
R3647 T11828 T11826 pobj mice,to
R3648 T11829 T11828 compound B6,mice
R3649 T11830 T11831 punct (,shown
R3650 T11831 T11811 parataxis shown,increased
R3651 T11832 T11831 nsubj data,shown
R3652 T11833 T11831 neg not,shown
R3653 T11834 T11831 punct ),shown
R3654 T11835 T11811 punct .,increased
R3655 T12715 T12716 compound Tail,bleeding
R3656 T12716 T12717 compound bleeding,assay
R3657 T12717 T12718 nsubj assay,identifies
R3658 T12719 T12720 nummod three,chromosomes
R3659 T12720 T12718 dobj chromosomes,identifies
R3660 T12721 T12720 prep with,chromosomes
R3661 T12722 T12721 pobj QTL,with
R3662 T12723 T12722 prep for,QTL
R3663 T12724 T12723 pobj rebleeding,for
R3664 T12725 T12718 prep in,identifies
R3665 T12726 T12725 pobj CSS,in
R3666 T12728 T12729 advcl Using,screened
R3667 T12730 T12731 det the,assay
R3668 T12731 T12728 dobj assay,Using
R3669 T12732 T12733 compound tail,rebleeding
R3670 T12733 T12731 compound rebleeding,assay
R3671 T12734 T12733 compound bleeding,rebleeding
R3672 T12735 T12733 punct /,rebleeding
R3673 T12736 T12728 prep as,Using
R3674 T12737 T12738 det a,marker
R3675 T12738 T12736 pobj marker,as
R3676 T12739 T12738 amod surrogate,marker
R3677 T12740 T12738 prep for,marker
R3678 T12741 T12740 pobj hemostasis,for
R3679 T12742 T12741 cc and,hemostasis
R3680 T12743 T12741 conj thrombosis,hemostasis
R3681 T12744 T12729 punct ", ",screened
R3682 T12745 T12746 det the,CSS
R3683 T12746 T12729 nsubjpass CSS,screened
R3684 T12747 T12729 auxpass were,screened
R3685 T12748 T12729 punct .,screened
R3686 T12750 T12751 det The,times
R3687 T12751 T12753 nsubj times,were
R3688 T12752 T12751 compound bleeding,times
R3689 T12754 T12755 punct (,4A
R3690 T12755 T12751 parataxis 4A,times
R3691 T12756 T12755 compound Figure,4A
R3692 T12757 T12755 punct ),4A
R3693 T12758 T12751 prep for,times
R3694 T12759 T12760 det the,B6
R3695 T12760 T12758 pobj B6,for
R3696 T12761 T12760 cc and,B6
R3697 T12762 T12763 det the,J
R3698 T12763 T12766 compound J,mice
R3699 T12764 T12763 compound A,J
R3700 T12765 T12763 punct /,J
R3701 T12766 T12760 conj mice,B6
R3702 T12767 T12753 neg not,were
R3703 T12768 T12753 acomp different,were
R3704 T12769 T12753 punct ", ",were
R3705 T12770 T12753 cc but,were
R3706 T12771 T12772 nsubj 6six,had
R3707 T12772 T12753 conj had,were
R3708 T12773 T12771 prep of,6six
R3709 T12774 T12775 det the,strains
R3710 T12775 T12773 pobj strains,of
R3711 T12776 T12771 punct ", ",6six
R3712 T12777 T12778 compound B6,Chr5
R3713 T12778 T12771 appos Chr5,6six
R3714 T12779 T12778 punct -,Chr5
R3715 T12780 T12778 punct ", ",Chr5
R3716 T12781 T12778 conj 6,Chr5
R3717 T12782 T12781 punct ", ",6
R3718 T12783 T12781 conj 8,6
R3719 T12784 T12783 punct ", ",8
R3720 T12785 T12783 conj 14,8
R3721 T12786 T12785 punct ", ",14
R3722 T12787 T12785 conj 15,14
R3723 T12788 T12787 punct ", ",15
R3724 T12789 T12787 cc and,15
R3725 T12790 T12791 compound YA,J
R3726 T12791 T12787 conj J,15
R3727 T12792 T12791 punct /,J
R3728 T12793 T12772 punct ", ",had
R3729 T12794 T12795 amod lower,times
R3730 T12795 T12772 dobj times,had
R3731 T12796 T12797 punct (,0.002
R3732 T12797 T12794 parataxis 0.002,lower
R3733 T12798 T12797 nsubj P,0.002
R3734 T12799 T12797 punct <,0.002
R3735 T12800 T12797 punct ),0.002
R3736 T12801 T12795 compound bleeding,times
R3737 T12802 T12795 punct (,times
R3738 T12803 T12804 quantmod 49,79
R3739 T12804 T12806 nummod 79,seconds
R3740 T12805 T12804 punct –,79
R3741 T12806 T12795 appos seconds,times
R3742 T12807 T12772 punct ),had
R3743 T12808 T12772 prep compared,had
R3744 T12809 T12808 prep to,compared
R3745 T12810 T12811 det the,value
R3746 T12811 T12809 pobj value,to
R3747 T12812 T12811 prep for,value
R3748 T12813 T12814 det the,mice
R3749 T12814 T12812 pobj mice,for
R3750 T12815 T12814 compound B6,mice
R3751 T12816 T12811 punct (,value
R3752 T12817 T12818 nummod 121,sec
R3753 T12818 T12811 appos sec,value
R3754 T12819 T12772 punct ),had
R3755 T12820 T12772 punct .,had
R3756 T12822 T12823 det The,time
R3757 T12823 T12825 nsubjpass time,increased
R3758 T12824 T12823 compound rebleeding,time
R3759 T12826 T12827 punct (,4B
R3760 T12827 T12823 parataxis 4B,time
R3761 T12828 T12827 compound Figure,4B
R3762 T12829 T12827 punct ),4B
R3763 T12830 T12823 punct ", ",time
R3764 T12831 T12823 acl determined,time
R3765 T12832 T12831 prep as,determined
R3766 T12833 T12834 det the,time
R3767 T12834 T12832 pobj time,as
R3768 T12835 T12834 prep between,time
R3769 T12836 T12837 compound bleeding,cessation
R3770 T12837 T12835 pobj cessation,between
R3771 T12838 T12837 cc and,cessation
R3772 T12839 T12837 conj initiation,cessation
R3773 T12840 T12839 prep of,initiation
R3774 T12841 T12842 det the,bleeding
R3775 T12842 T12840 pobj bleeding,of
R3776 T12843 T12842 amod second,bleeding
R3777 T12844 T12825 punct ", ",increased
R3778 T12845 T12825 auxpass was,increased
R3779 T12846 T12825 advmod markedly,increased
R3780 T12847 T12825 prep in,increased
R3781 T12848 T12849 det the,mice
R3782 T12849 T12847 pobj mice,in
R3783 T12850 T12851 compound A,J
R3784 T12851 T12849 compound J,mice
R3785 T12852 T12851 punct /,J
R3786 T12853 T12825 prep compared,increased
R3787 T12854 T12853 prep to,compared
R3788 T12855 T12856 det the,mice
R3789 T12856 T12854 pobj mice,to
R3790 T12857 T12856 compound B6,mice
R3791 T12858 T12825 cc and,increased
R3792 T12859 T12860 nummod two,strains
R3793 T12860 T12861 nsubj strains,had
R3794 T12861 T12825 conj had,increased
R3795 T12862 T12860 punct ", ",strains
R3796 T12863 T12864 compound B6,Chr11A
R3797 T12864 T12866 compound Chr11A,J
R3798 T12865 T12864 punct -,Chr11A
R3799 T12866 T12860 appos J,strains
R3800 T12867 T12866 punct /,J
R3801 T12868 T12866 punct (,J
R3802 T12869 T12866 appos CSS,J
R3803 T12870 T12869 punct -,CSS
R3804 T12871 T12869 nummod 11,CSS
R3805 T12872 T12866 punct ),J
R3806 T12873 T12866 cc and,J
R3807 T12874 T12875 compound B6,Chr17A
R3808 T12875 T12877 compound Chr17A,J
R3809 T12876 T12875 punct -,Chr17A
R3810 T12877 T12866 conj J,J
R3811 T12878 T12877 punct /,J
R3812 T12879 T12877 punct (,J
R3813 T12880 T12877 appos CSS,J
R3814 T12881 T12880 punct -,CSS
R3815 T12882 T12880 nummod 17,CSS
R3816 T12883 T12861 punct ),had
R3817 T12884 T12861 punct ", ",had
R3818 T12885 T12886 advmod significantly,longer
R3819 T12886 T12892 amod longer,times
R3820 T12887 T12888 punct (,0.002
R3821 T12888 T12885 parataxis 0.002,significantly
R3822 T12889 T12888 nsubj P,0.002
R3823 T12890 T12888 punct <,0.002
R3824 T12891 T12888 punct ),0.002
R3825 T12892 T12861 dobj times,had
R3826 T12893 T12892 compound rebleeding,times
R3827 T12894 T12861 prep compared,had
R3828 T12895 T12894 prep to,compared
R3829 T12896 T12897 det the,mice
R3830 T12897 T12895 pobj mice,to
R3831 T12898 T12897 compound B6,mice
R3832 T12899 T12900 dep that,were
R3833 T12900 T12897 relcl were,mice
R3834 T12901 T12900 acomp similar,were
R3835 T12902 T12901 prep to,similar
R3836 T12903 T12902 pobj values,to
R3837 T12904 T12903 prep from,values
R3838 T12905 T12906 det the,mice
R3839 T12906 T12904 pobj mice,from
R3840 T12907 T12908 compound A,J
R3841 T12908 T12906 compound J,mice
R3842 T12909 T12908 punct /,J
R3843 T12910 T12861 punct .,had
R3844 T12912 T12913 det Another,strain
R3845 T12913 T12914 nsubj strain,approached
R3846 T12915 T12913 punct ", ",strain
R3847 T12916 T12917 compound B6,Chr5A
R3848 T12917 T12919 compound Chr5A,J
R3849 T12918 T12917 punct -,Chr5A
R3850 T12919 T12913 appos J,strain
R3851 T12920 T12919 punct /,J
R3852 T12921 T12919 punct (,J
R3853 T12922 T12919 appos CSS,J
R3854 T12923 T12922 punct -,CSS
R3855 T12924 T12922 nummod 5,CSS
R3856 T12925 T12914 punct ),approached
R3857 T12926 T12914 punct ", ",approached
R3858 T12927 T12914 dobj significance,approached
R3859 T12928 T12914 prep at,approached
R3860 T12929 T12928 pobj P,at
R3861 T12930 T12931 punct <,0.008
R3862 T12931 T12929 amod 0.008,P
R3863 T12932 T12914 punct .,approached
R3864 T12934 T12935 det The,time
R3865 T12935 T12937 nsubjpass time,stopped
R3866 T12936 T12935 compound rebleeding,time
R3867 T12938 T12937 auxpass was,stopped
R3868 T12939 T12937 prep at,stopped
R3869 T12940 T12941 nummod 600,sec
R3870 T12941 T12939 pobj sec,at
R3871 T12942 T12937 punct ", ",stopped
R3872 T12943 T12937 cc and,stopped
R3873 T12944 T12945 det the,percentage
R3874 T12945 T12946 nsubj percentage,determined
R3875 T12946 T12937 conj determined,stopped
R3876 T12947 T12945 prep of,percentage
R3877 T12948 T12947 pobj mice,of
R3878 T12949 T12948 prep with,mice
R3879 T12950 T12951 det this,value
R3880 T12951 T12949 pobj value,with
R3881 T12952 T12946 prep for,determined
R3882 T12953 T12954 det the,strains
R3883 T12954 T12952 pobj strains,for
R3884 T12955 T12954 nummod three,strains
R3885 T12956 T12937 punct : ,stopped
R3886 T12957 T12958 dep CSS,%
R3887 T12958 T12937 dep %,stopped
R3888 T12959 T12957 punct -,CSS
R3889 T12960 T12957 nummod 5,CSS
R3890 T12961 T12958 punct –,%
R3891 T12962 T12958 nummod 60,%
R3892 T12963 T12958 punct ", ",%
R3893 T12964 T12965 dep CSS,%
R3894 T12965 T12958 conj %,%
R3895 T12966 T12964 punct -,CSS
R3896 T12967 T12964 nummod 11,CSS
R3897 T12968 T12965 punct –,%
R3898 T12969 T12965 compound 60,%
R3899 T12970 T12965 cc and,%
R3900 T12971 T12972 compound CSS,A17
R3901 T12972 T12974 dep A17,%
R3902 T12973 T12972 punct -,A17
R3903 T12974 T12965 conj %,%
R3904 T12975 T12974 punct –,%
R3905 T12976 T12974 nummod 46,%
R3906 T12977 T12937 punct .,stopped
R3907 T12979 T12980 det The,percentage
R3908 T12980 T12981 nsubj percentage,was
R3909 T12982 T12980 prep of,percentage
R3910 T12983 T12984 compound B6,mice
R3911 T12984 T12982 pobj mice,of
R3912 T12985 T12980 prep with,percentage
R3913 T12986 T12987 det a,time
R3914 T12987 T12985 pobj time,with
R3915 T12988 T12987 compound rebleeding,time
R3916 T12989 T12987 prep of,time
R3917 T12990 T12991 nummod 600,sec
R3918 T12991 T12989 pobj sec,of
R3919 T12992 T12993 nummod 7,%
R3920 T12993 T12981 attr %,was
R3921 T12994 T12981 cc and,was
R3922 T12995 T12996 prep for,was
R3923 T12996 T12981 conj was,was
R3924 T12997 T12998 det the,mice
R3925 T12998 T12995 pobj mice,for
R3926 T12999 T13000 compound A,J
R3927 T13000 T12998 compound J,mice
R3928 T13001 T13000 punct /,J
R3929 T13002 T13003 det the,percentage
R3930 T13003 T12996 nsubj percentage,was
R3931 T13004 T13005 nummod 85,%
R3932 T13005 T12996 attr %,was
R3933 T13006 T12996 punct .,was
R3934 T13008 T13009 compound Rebleeding,time
R3935 T13009 T13010 nsubjpass time,compared
R3936 T13011 T13009 prep in,time
R3937 T13012 T13013 det the,strains
R3938 T13013 T13011 pobj strains,in
R3939 T13014 T13013 compound parent,strains
R3940 T13015 T13013 cc and,strains
R3941 T13016 T13013 conj CSS,strains
R3942 T13017 T13010 auxpass were,compared
R3943 T13018 T13010 prep to,compared
R3944 T13019 T13018 pobj values,to
R3945 T13020 T13019 prep from,values
R3946 T13021 T13022 det the,progeny
R3947 T13022 T13020 pobj progeny,from
R3948 T13023 T13022 prep of,progeny
R3949 T13024 T13023 pobj mice,of
R3950 T13025 T13026 dep that,crossed
R3951 T13026 T13024 relcl crossed,mice
R3952 T13027 T13026 auxpass were,crossed
R3953 T13028 T13026 prep with,crossed
R3954 T13029 T13030 compound B6,mice
R3955 T13030 T13028 pobj mice,with
R3956 T13031 T13032 aux to,produce
R3957 T13032 T13026 advcl produce,crossed
R3958 T13033 T13034 amod heterosomic,mice
R3959 T13034 T13032 dobj mice,produce
R3960 T13035 T13032 prep for,produce
R3961 T13036 T13037 det the,strains
R3962 T13037 T13035 pobj strains,for
R3963 T13038 T13039 nmod CSS,F1
R3964 T13039 T13037 nmod F1,strains
R3965 T13040 T13038 punct -,CSS
R3966 T13041 T13038 nummod 5,CSS
R3967 T13042 T13038 punct ", ",CSS
R3968 T13043 T13038 punct (,CSS
R3969 T13044 T13038 appos B6xCSS,CSS
R3970 T13045 T13044 punct -,B6xCSS
R3971 T13046 T13044 nummod 5,B6xCSS
R3972 T13047 T13039 punct ),F1
R3973 T13048 T13039 cc and,F1
R3974 T13049 T13050 nmod CSS,F1
R3975 T13050 T13039 conj F1,F1
R3976 T13051 T13049 punct -,CSS
R3977 T13052 T13049 nummod 17,CSS
R3978 T13053 T13049 punct (,CSS
R3979 T13054 T13049 appos B6xCSS,CSS
R3980 T13055 T13054 punct -,B6xCSS
R3981 T13056 T13054 nummod 17,B6xCSS
R3982 T13057 T13050 punct ),F1
R3983 T13058 T13059 punct (,Figure
R3984 T13059 T13032 parataxis Figure,produce
R3985 T13060 T13059 nummod 5,Figure
R3986 T13061 T13059 punct ),Figure
R3987 T13062 T13010 punct .,compared
R3988 T13064 T13065 det The,values
R3989 T13065 T13067 nsubj values,were
R3990 T13066 T13065 compound rebleeding,values
R3991 T13068 T13065 prep for,values
R3992 T13069 T13070 nmod CSS,5F1
R3993 T13070 T13072 nmod 5F1,mice
R3994 T13071 T13070 punct -,5F1
R3995 T13072 T13068 pobj mice,for
R3996 T13073 T13070 cc and,5F1
R3997 T13074 T13075 compound CSS,17F1
R3998 T13075 T13070 conj 17F1,5F1
R3999 T13076 T13075 punct -,17F1
R4000 T13077 T13067 acomp similar,were
R4001 T13078 T13077 prep to,similar
R4002 T13079 T13080 det the,B6
R4003 T13080 T13078 pobj B6,to
R4004 T13081 T13082 advmod rather,than
R4005 T13082 T13080 cc than,B6
R4006 T13083 T13084 det the,J
R4007 T13084 T13087 compound J,mice
R4008 T13085 T13084 compound A,J
R4009 T13086 T13084 punct /,J
R4010 T13087 T13080 conj mice,B6
R4011 T13088 T13067 punct ", ",were
R4012 T13089 T13067 advcl suggesting,were
R4013 T13090 T13091 det the,trait
R4014 T13091 T13095 nsubj trait,is
R4015 T13092 T13093 compound A,J
R4016 T13093 T13091 compound J,trait
R4017 T13094 T13093 punct /,J
R4018 T13095 T13089 advcl is,suggesting
R4019 T13096 T13095 acomp recessive,is
R4020 T13097 T13067 punct .,were
R4021 T13099 T13100 nsubj Bleeding,resulted
R4022 T13101 T13099 cc and,Bleeding
R4023 T13102 T13099 conj rebleeding,Bleeding
R4024 T13103 T13099 prep in,Bleeding
R4025 T13104 T13105 det the,progeny
R4026 T13105 T13103 pobj progeny,in
R4027 T13106 T13105 prep of,progeny
R4028 T13107 T13108 det the,cross
R4029 T13108 T13106 pobj cross,of
R4030 T13109 T13108 punct ", ",cross
R4031 T13110 T13111 compound B6,J
R4032 T13111 T13108 appos J,cross
R4033 T13112 T13111 punct -,J
R4034 T13113 T13111 compound Chr5A,J
R4035 T13114 T13111 punct /,J
R4036 T13115 T13111 punct ×,J
R4037 T13116 T13117 compound B6,J
R4038 T13117 T13111 appos J,J
R4039 T13118 T13117 punct -,J
R4040 T13119 T13117 compound Chr17A,J
R4041 T13120 T13117 punct /,J
R4042 T13121 T13111 punct (,J
R4043 T13122 T13111 appos CSS,J
R4044 T13123 T13122 punct -,CSS
R4045 T13124 T13122 nummod 5,CSS
R4046 T13125 T13122 punct ×,CSS
R4047 T13126 T13122 appos CSS,CSS
R4048 T13127 T13126 punct -,CSS
R4049 T13128 T13126 nummod 17,CSS
R4050 T13129 T13100 punct ),resulted
R4051 T13130 T13100 prep in,resulted
R4052 T13131 T13132 det the,recovery
R4053 T13132 T13130 pobj recovery,in
R4054 T13133 T13132 prep of,recovery
R4055 T13134 T13135 det the,phenotype
R4056 T13135 T13133 pobj phenotype,of
R4057 T13136 T13137 compound A,J
R4058 T13137 T13135 compound J,phenotype
R4059 T13138 T13137 punct /,J
R4060 T13139 T13132 prep in,recovery
R4061 T13140 T13141 det the,progeny
R4062 T13141 T13139 pobj progeny,in
R4063 T13142 T13141 prep of,progeny
R4064 T13143 T13144 det these,strains
R4065 T13144 T13142 pobj strains,of
R4066 T13145 T13146 amod double,heterosomic
R4067 T13146 T13144 amod heterosomic,strains
R4068 T13147 T13100 punct .,resulted
R4069 T13149 T13150 advmod Thus,was
R4070 T13151 T13150 punct ", ",was
R4071 T13152 T13150 prep despite,was
R4072 T13153 T13154 det the,chromosomes
R4073 T13154 T13152 pobj chromosomes,despite
R4074 T13155 T13154 amod heterosomic,chromosomes
R4075 T13156 T13154 prep of,chromosomes
R4076 T13157 T13156 pobj 5,of
R4077 T13158 T13157 cc and,5
R4078 T13159 T13157 conj 17,5
R4079 T13160 T13154 prep in,chromosomes
R4080 T13161 T13162 det the,progeny
R4081 T13162 T13160 pobj progeny,in
R4082 T13163 T13162 prep of,progeny
R4083 T13164 T13165 det the,CSS
R4084 T13165 T13163 pobj CSS,of
R4085 T13166 T13165 punct -,CSS
R4086 T13167 T13165 nummod 5,CSS
R4087 T13168 T13165 punct ×,CSS
R4088 T13169 T13165 appos CSS,CSS
R4089 T13170 T13169 punct -,CSS
R4090 T13171 T13169 nummod 17,CSS
R4091 T13172 T13150 punct ", ",was
R4092 T13173 T13174 det the,phenotype
R4093 T13174 T13150 nsubj phenotype,was
R4094 T13175 T13150 advmod now,was
R4095 T13176 T13150 acomp similar,was
R4096 T13177 T13176 prep to,similar
R4097 T13178 T13179 compound A,J
R4098 T13179 T13177 pobj J,to
R4099 T13180 T13179 punct /,J
R4100 T13181 T13150 punct .,was
R4101 T13183 T13184 nsubj This,suggested
R4102 T13185 T13186 mark that,interacting
R4103 T13186 T13184 ccomp interacting,suggested
R4104 T13187 T13186 nsubj traits,interacting
R4105 T13188 T13187 prep on,traits
R4106 T13189 T13190 det the,chromosomes
R4107 T13190 T13188 pobj chromosomes,on
R4108 T13191 T13192 compound A,J
R4109 T13192 T13190 compound J,chromosomes
R4110 T13193 T13192 punct /,J
R4111 T13194 T13186 aux were,interacting
R4112 T13195 T13196 aux to,produce
R4113 T13196 T13186 advcl produce,interacting
R4114 T13197 T13198 det the,phenotype
R4115 T13198 T13196 dobj phenotype,produce
R4116 T13199 T13184 punct .,suggested
R4117 T14100 T14099 prep of,Interactions
R4118 T14101 T14100 pobj CSS,of
R4119 T14102 T14099 prep for,Interactions
R4120 T14103 T14102 pobj PAI,for
R4121 T14104 T14103 punct -,PAI
R4122 T14105 T14103 nummod 1,PAI
R4123 T14106 T14103 appos antigen,PAI
R4124 T14107 T14106 cc and,antigen
R4125 T14108 T14106 conj activity,antigen
R4126 T14110 T14111 nsubj Components,reside
R4127 T14112 T14110 prep of,Components
R4128 T14113 T14114 det the,system
R4129 T14114 T14112 pobj system,of
R4130 T14115 T14114 compound Plg,system
R4131 T14116 T14111 prep on,reside
R4132 T14117 T14118 compound chromosomes,CSS
R4133 T14118 T14116 pobj CSS,on
R4134 T14119 T14118 punct -,CSS
R4135 T14120 T14118 nummod 5,CSS
R4136 T14121 T14118 punct (,CSS
R4137 T14122 T14118 appos PAI,CSS
R4138 T14123 T14122 punct -,PAI
R4139 T14124 T14122 nummod 1,PAI
R4140 T14125 T14118 punct ),CSS
R4141 T14126 T14118 punct ", ",CSS
R4142 T14127 T14118 conj CSS,CSS
R4143 T14128 T14127 punct -,CSS
R4144 T14129 T14127 nummod 11,CSS
R4145 T14130 T14127 punct (,CSS
R4146 T14131 T14132 compound α2,antiplasmin
R4147 T14132 T14127 appos antiplasmin,CSS
R4148 T14133 T14132 punct -,antiplasmin
R4149 T14134 T14127 punct ),CSS
R4150 T14135 T14127 punct ", ",CSS
R4151 T14136 T14127 cc and,CSS
R4152 T14137 T14127 conj CSS,CSS
R4153 T14138 T14137 punct -,CSS
R4154 T14139 T14137 nummod 17,CSS
R4155 T14140 T14137 punct (,CSS
R4156 T14141 T14137 appos Plg,CSS
R4157 T14142 T14111 punct ),reside
R4158 T14143 T14111 punct .,reside
R4159 T14145 T14146 mark As,reported
R4160 T14146 T14147 advcl reported,had
R4161 T14148 T14146 prep in,reported
R4162 T14149 T14148 pobj Table,in
R4163 T14150 T14149 nummod 2,Table
R4164 T14151 T14147 punct ", ",had
R4165 T14152 T14153 det the,mice
R4166 T14153 T14147 nsubj mice,had
R4167 T14154 T14155 compound A,J
R4168 T14155 T14153 compound J,mice
R4169 T14156 T14155 punct /,J
R4170 T14157 T14158 amod increased,antigen
R4171 T14158 T14147 dobj antigen,had
R4172 T14159 T14158 compound Plg,antigen
R4173 T14160 T14158 punct ", ",antigen
R4174 T14161 T14162 amod fibrinolytic,activity
R4175 T14162 T14158 conj activity,antigen
R4176 T14163 T14162 punct ", ",activity
R4177 T14164 T14165 compound α2,antiplasmin
R4178 T14165 T14162 conj antiplasmin,activity
R4179 T14166 T14165 punct -,antiplasmin
R4180 T14167 T14165 punct ", ",antiplasmin
R4181 T14168 T14169 nmod PAI,activity
R4182 T14169 T14165 conj activity,antiplasmin
R4183 T14170 T14168 punct -,PAI
R4184 T14171 T14168 nummod 1,PAI
R4185 T14172 T14169 cc and,activity
R4186 T14173 T14169 conj fibrinogen,activity
R4187 T14174 T14175 advmod when,compared
R4188 T14175 T14147 advcl compared,had
R4189 T14176 T14175 prep to,compared
R4190 T14177 T14178 compound B6,mice
R4191 T14178 T14176 pobj mice,to
R4192 T14179 T14147 punct .,had
R4193 T14181 T14182 prep In,was
R4194 T14183 T14184 nmod CSS,mice
R4195 T14184 T14181 pobj mice,In
R4196 T14185 T14183 punct -,CSS
R4197 T14186 T14183 nummod 17,CSS
R4198 T14187 T14182 punct ", ",was
R4199 T14188 T14189 det the,antigen
R4200 T14189 T14182 nsubj antigen,was
R4201 T14190 T14189 compound Plg,antigen
R4202 T14191 T14182 advmod also,was
R4203 T14192 T14193 advmod significantly,increased
R4204 T14193 T14182 acomp increased,was
R4205 T14194 T14195 punct (,0.015
R4206 T14195 T14192 parataxis 0.015,significantly
R4207 T14196 T14195 nsubj P,0.015
R4208 T14197 T14195 punct =,0.015
R4209 T14198 T14195 punct ),0.015
R4210 T14199 T14200 punct (,6
R4211 T14200 T14193 parataxis 6,increased
R4212 T14201 T14200 nummod 152,6
R4213 T14202 T14200 punct ±,6
R4214 T14203 T14200 punct ", ",6
R4215 T14204 T14205 nsubj n,12
R4216 T14205 T14200 ccomp 12,6
R4217 T14206 T14205 punct =,12
R4218 T14207 T14200 punct ),6
R4219 T14208 T14209 advmod when,compared
R4220 T14209 T14182 advcl compared,was
R4221 T14210 T14209 prep to,compared
R4222 T14211 T14212 det the,mice
R4223 T14212 T14210 pobj mice,to
R4224 T14213 T14212 compound B6,mice
R4225 T14214 T14182 punct ", ",was
R4226 T14215 T14182 cc but,was
R4227 T14216 T14217 prep for,was
R4228 T14217 T14182 conj was,was
R4229 T14218 T14216 pobj CSS,for
R4230 T14219 T14218 punct -,CSS
R4231 T14220 T14218 nummod 5,CSS
R4232 T14221 T14218 cc and,CSS
R4233 T14222 T14218 conj CSS,CSS
R4234 T14223 T14222 punct -,CSS
R4235 T14224 T14222 nummod 5,CSS
R4236 T14225 T14222 punct ×,CSS
R4237 T14226 T14222 nummod 17,CSS
R4238 T14227 T14217 punct ", ",was
R4239 T14228 T14229 det the,antigen
R4240 T14229 T14217 nsubj antigen,was
R4241 T14230 T14229 compound Plg,antigen
R4242 T14231 T14217 acomp similar,was
R4243 T14232 T14231 prep to,similar
R4244 T14233 T14232 pobj values,to
R4245 T14234 T14233 prep for,values
R4246 T14235 T14236 det the,mice
R4247 T14236 T14234 pobj mice,for
R4248 T14237 T14236 compound B6,mice
R4249 T14238 T14217 punct .,was
R4250 T14240 T14241 amod Fibrinolytic,activity
R4251 T14241 T14242 nsubj activity,was
R4252 T14243 T14242 neg not,was
R4253 T14244 T14242 acomp different,was
R4254 T14245 T14244 prep in,different
R4255 T14246 T14247 det the,strains
R4256 T14247 T14245 pobj strains,in
R4257 T14248 T14247 nmod CSS,strains
R4258 T14249 T14248 punct -,CSS
R4259 T14250 T14248 nummod 5,CSS
R4260 T14251 T14248 cc or,CSS
R4261 T14252 T14248 conj CSS,CSS
R4262 T14253 T14252 punct -,CSS
R4263 T14254 T14252 nummod 17,CSS
R4264 T14255 T14242 prep compared,was
R4265 T14256 T14255 prep to,compared
R4266 T14257 T14258 det the,mice
R4267 T14258 T14256 pobj mice,to
R4268 T14259 T14258 compound B6,mice
R4269 T14260 T14242 punct .,was
R4270 T14262 T14263 compound α2,antiplasmin
R4271 T14263 T14265 nsubj antiplasmin,was
R4272 T14264 T14263 punct -,antiplasmin
R4273 T14266 T14267 advmod significantly,reduced
R4274 T14267 T14265 acomp reduced,was
R4275 T14268 T14269 punct (,0.01
R4276 T14269 T14266 parataxis 0.01,significantly
R4277 T14270 T14269 nsubj P,0.01
R4278 T14271 T14269 punct =,0.01
R4279 T14272 T14269 punct <,0.01
R4280 T14273 T14269 punct ),0.01
R4281 T14274 T14265 prep in,was
R4282 T14275 T14276 nmod CSS,mice
R4283 T14276 T14274 pobj mice,in
R4284 T14277 T14275 punct -,CSS
R4285 T14278 T14275 nummod 5,CSS
R4286 T14279 T14280 punct (,μg
R4287 T14280 T14276 parataxis μg,mice
R4288 T14281 T14282 quantmod 142,4
R4289 T14282 T14280 nummod 4,μg
R4290 T14283 T14282 punct ±,4
R4291 T14284 T14285 punct /,mL
R4292 T14285 T14280 prep mL,μg
R4293 T14286 T14280 punct ", ",μg
R4294 T14287 T14288 nsubj n,5
R4295 T14288 T14280 ccomp 5,μg
R4296 T14289 T14288 punct =,5
R4297 T14290 T14280 punct ),μg
R4298 T14291 T14265 punct ", ",was
R4299 T14292 T14293 advmod significantly,higher
R4300 T14293 T14265 conj higher,was
R4301 T14294 T14295 punct (,0.05
R4302 T14295 T14292 parataxis 0.05,significantly
R4303 T14296 T14295 nsubj P,0.05
R4304 T14297 T14295 punct <,0.05
R4305 T14298 T14295 punct ),0.05
R4306 T14299 T14293 prep in,higher
R4307 T14300 T14301 det the,CSS
R4308 T14301 T14299 pobj CSS,in
R4309 T14302 T14301 punct -,CSS
R4310 T14303 T14301 nummod 11,CSS
R4311 T14304 T14305 punct (,6
R4312 T14305 T14301 parataxis 6,CSS
R4313 T14306 T14305 quantmod 201,6
R4314 T14307 T14305 punct ±,6
R4315 T14308 T14305 punct ", ",6
R4316 T14309 T14310 nsubj n,8
R4317 T14310 T14305 ccomp 8,6
R4318 T14311 T14310 punct =,8
R4319 T14312 T14305 punct ),6
R4320 T14313 T14293 punct ", ",higher
R4321 T14314 T14293 cc but,higher
R4322 T14315 T14316 neg not,different
R4323 T14316 T14293 conj different,higher
R4324 T14317 T14316 prep in,different
R4325 T14318 T14319 nmod CSS,mice
R4326 T14319 T14317 pobj mice,in
R4327 T14320 T14318 punct -,CSS
R4328 T14321 T14318 nummod 17,CSS
R4329 T14322 T14318 cc or,CSS
R4330 T14323 T14318 conj CSS,CSS
R4331 T14324 T14323 punct -,CSS
R4332 T14325 T14323 nummod 5,CSS
R4333 T14326 T14323 punct ×,CSS
R4334 T14327 T14323 nummod 17,CSS
R4335 T14328 T14316 prep compared,different
R4336 T14329 T14328 prep to,compared
R4337 T14330 T14331 det the,mice
R4338 T14331 T14329 pobj mice,to
R4339 T14332 T14331 compound B6,mice
R4340 T14333 T14265 punct .,was
R4341 T14335 T14336 nsubjpass PAI,determined
R4342 T14337 T14335 punct -,PAI
R4343 T14338 T14335 nummod 1,PAI
R4344 T14339 T14335 appos antigen,PAI
R4345 T14340 T14339 cc and,antigen
R4346 T14341 T14339 conj activity,antigen
R4347 T14342 T14336 auxpass were,determined
R4348 T14343 T14336 prep in,determined
R4349 T14344 T14345 det the,CSS
R4350 T14345 T14343 pobj CSS,in
R4351 T14346 T14345 prep with,CSS
R4352 T14347 T14348 amod increased,times
R4353 T14348 T14346 pobj times,with
R4354 T14349 T14348 compound rebleeding,times
R4355 T14350 T14345 punct ", ",CSS
R4356 T14351 T14345 appos CSS,CSS
R4357 T14352 T14351 punct -,CSS
R4358 T14353 T14351 nummod 5,CSS
R4359 T14354 T14351 punct ", ",CSS
R4360 T14355 T14351 conj CSS,CSS
R4361 T14356 T14355 punct -,CSS
R4362 T14357 T14355 nummod 11,CSS
R4363 T14358 T14355 punct ", ",CSS
R4364 T14359 T14355 cc and,CSS
R4365 T14360 T14355 conj CSS,CSS
R4366 T14361 T14360 punct -,CSS
R4367 T14362 T14360 nummod 17,CSS
R4368 T14363 T14364 punct (,Figure
R4369 T14364 T14360 parataxis Figure,CSS
R4370 T14365 T14364 nummod 6,Figure
R4371 T14366 T14364 punct ),Figure
R4372 T14367 T14345 punct ", ",CSS
R4373 T14368 T14369 det the,heterosomic
R4374 T14369 T14345 conj heterosomic,CSS
R4375 T14370 T14369 punct ", ",heterosomic
R4376 T14371 T14372 compound CSS,5F1
R4377 T14372 T14369 appos 5F1,heterosomic
R4378 T14373 T14372 punct -,5F1
R4379 T14374 T14372 punct ", ",5F1
R4380 T14375 T14376 compound CSS,17F1
R4381 T14376 T14372 appos 17F1,5F1
R4382 T14377 T14376 punct -,17F1
R4383 T14378 T14369 punct ", ",heterosomic
R4384 T14379 T14369 cc and,heterosomic
R4385 T14380 T14381 amod double,hetersomic
R4386 T14381 T14369 conj hetersomic,heterosomic
R4387 T14382 T14381 punct ", ",hetersomic
R4388 T14383 T14381 appos CSS,hetersomic
R4389 T14384 T14383 punct -,CSS
R4390 T14385 T14383 nummod 5,CSS
R4391 T14386 T14383 punct ×,CSS
R4392 T14387 T14383 nummod 17,CSS
R4393 T14388 T14336 punct .,determined
R4394 T14390 T14391 nsubj CSS,had
R4395 T14392 T14390 punct -,CSS
R4396 T14393 T14390 nummod 5,CSS
R4397 T14394 T14390 punct ", ",CSS
R4398 T14395 T14390 conj CSS,CSS
R4399 T14396 T14395 punct -,CSS
R4400 T14397 T14395 nummod 17,CSS
R4401 T14398 T14395 punct ", ",CSS
R4402 T14399 T14400 compound CSS,5F1
R4403 T14400 T14395 conj 5F1,CSS
R4404 T14401 T14400 punct -,5F1
R4405 T14402 T14400 punct ", ",5F1
R4406 T14403 T14400 cc and,5F1
R4407 T14404 T14405 compound CSS,17F1
R4408 T14405 T14400 conj 17F1,5F1
R4409 T14406 T14405 punct -,17F1
R4410 T14407 T14391 advmod generally,had
R4411 T14408 T14409 amod reduced,antigen
R4412 T14409 T14391 dobj antigen,had
R4413 T14410 T14409 nmod PAI,antigen
R4414 T14411 T14410 punct -,PAI
R4415 T14412 T14410 nummod 1,PAI
R4416 T14413 T14414 advmod when,compared
R4417 T14414 T14391 advcl compared,had
R4418 T14415 T14414 prep to,compared
R4419 T14416 T14417 compound B6,mice
R4420 T14417 T14415 pobj mice,to
R4421 T14418 T14391 punct .,had
R4422 T14420 T14421 det The,antigen
R4423 T14421 T14426 nsubj antigen,was
R4424 T14422 T14421 amod reduced,antigen
R4425 T14423 T14421 nmod PAI,antigen
R4426 T14424 T14423 punct -,PAI
R4427 T14425 T14423 nummod 1,PAI
R4428 T14427 T14428 det a,trait
R4429 T14428 T14426 attr trait,was
R4430 T14429 T14428 amod dominant,trait
R4431 T14430 T14426 prep due,was
R4432 T14431 T14430 pcomp to,due
R4433 T14432 T14433 det the,fact
R4434 T14433 T14430 pobj fact,due
R4435 T14434 T14435 mark that,were
R4436 T14435 T14433 acl were,fact
R4437 T14436 T14437 det the,values
R4438 T14437 T14435 nsubj values,were
R4439 T14438 T14435 acomp similar,were
R4440 T14439 T14438 prep in,similar
R4441 T14440 T14441 det the,CSS
R4442 T14441 T14439 pobj CSS,in
R4443 T14442 T14441 amod homosomic,CSS
R4444 T14443 T14442 cc and,homosomic
R4445 T14444 T14442 conj heterosomic,homosomic
R4446 T14445 T14441 punct -,CSS
R4447 T14446 T14441 nummod 5,CSS
R4448 T14447 T14441 cc and,CSS
R4449 T14448 T14441 conj CSS,CSS
R4450 T14449 T14448 punct -,CSS
R4451 T14450 T14448 nummod 17,CSS
R4452 T14451 T14426 punct .,was
R4453 T14453 T14454 det The,strains
R4454 T14454 T14464 nsubj strains,had
R4455 T14455 T14454 nmod CSS,strains
R4456 T14456 T14455 punct -,CSS
R4457 T14457 T14455 nummod 5,CSS
R4458 T14458 T14455 punct ×,CSS
R4459 T14459 T14455 appos CSS,CSS
R4460 T14460 T14459 punct -,CSS
R4461 T14461 T14459 nummod 17,CSS
R4462 T14462 T14463 amod double,heterosomic
R4463 T14463 T14454 amod heterosomic,strains
R4464 T14465 T14464 dobj values,had
R4465 T14466 T14465 amod similar,values
R4466 T14467 T14466 prep to,similar
R4467 T14468 T14469 det the,strains
R4468 T14469 T14467 pobj strains,to
R4469 T14470 T14469 nmod B6,strains
R4470 T14471 T14470 cc and,B6
R4471 T14472 T14473 compound A,J
R4472 T14473 T14470 conj J,B6
R4473 T14474 T14473 punct /,J
R4474 T14475 T14469 compound parent,strains
R4475 T14476 T14464 punct .,had
R4476 T14478 T14479 nmod PAI,activity
R4477 T14479 T14482 nsubjpass activity,reduced
R4478 T14480 T14478 punct -,PAI
R4479 T14481 T14478 nummod 1,PAI
R4480 T14483 T14482 auxpass was,reduced
R4481 T14484 T14482 advmod significantly,reduced
R4482 T14485 T14482 prep in,reduced
R4483 T14486 T14487 det the,mice
R4484 T14487 T14485 pobj mice,in
R4485 T14488 T14487 nmod CSS,mice
R4486 T14489 T14488 punct -,CSS
R4487 T14490 T14488 nummod 5,CSS
R4488 T14491 T14488 cc and,CSS
R4489 T14492 T14493 compound CSS,17F1
R4490 T14493 T14488 conj 17F1,CSS
R4491 T14494 T14493 punct -,17F1
R4492 T14495 T14482 punct ", ",reduced
R4493 T14496 T14482 cc but,reduced
R4494 T14497 T14498 advmod again,restored
R4495 T14498 T14482 conj restored,reduced
R4496 T14499 T14498 prep in,restored
R4497 T14500 T14501 det the,strain
R4498 T14501 T14499 pobj strain,in
R4499 T14502 T14501 nmod CSS,strain
R4500 T14503 T14502 punct -,CSS
R4501 T14504 T14502 nummod 5,CSS
R4502 T14505 T14502 punct ×,CSS
R4503 T14506 T14502 appos CSS,CSS
R4504 T14507 T14506 punct -,CSS
R4505 T14508 T14506 nummod 17,CSS
R4506 T14509 T14510 det the,value
R4507 T14510 T14498 nsubjpass value,restored
R4508 T14511 T14510 prep for,value
R4509 T14512 T14513 nmod PAI,activity
R4510 T14513 T14511 pobj activity,for
R4511 T14514 T14512 punct -,PAI
R4512 T14515 T14512 nummod 1,PAI
R4513 T14516 T14498 auxpass was,restored
R4514 T14517 T14498 prep to,restored
R4515 T14518 T14519 det the,value
R4516 T14519 T14517 pobj value,to
R4517 T14520 T14519 prep of,value
R4518 T14521 T14522 det the,strains
R4519 T14522 T14520 pobj strains,of
R4520 T14523 T14522 nmod B6,strains
R4521 T14524 T14523 cc and,B6
R4522 T14525 T14526 compound A,J
R4523 T14526 T14523 conj J,B6
R4524 T14527 T14526 punct /,J
R4525 T14528 T14522 compound parent,strains
R4526 T14529 T14498 punct .,restored
R4527 T14531 T14532 det The,antigen
R4528 T14532 T14536 nsubj antigen,was
R4529 T14533 T14532 nmod PAI,antigen
R4530 T14534 T14533 punct -,PAI
R4531 T14535 T14533 nummod 1,PAI
R4532 T14537 T14538 punct (,ng
R4533 T14538 T14532 parataxis ng,antigen
R4534 T14539 T14538 nummod 5.4,ng
R4535 T14540 T14541 punct /,mL
R4536 T14541 T14538 prep mL,ng
R4537 T14542 T14543 punct ±,0.5
R4538 T14543 T14538 nummod 0.5,ng
R4539 T14544 T14538 punct ", ",ng
R4540 T14545 T14546 nsubj n,7
R4541 T14546 T14538 ccomp 7,ng
R4542 T14547 T14546 punct =,7
R4543 T14548 T14538 punct ),ng
R4544 T14549 T14532 cc and,antigen
R4545 T14550 T14532 conj activity,antigen
R4546 T14551 T14552 punct (,U
R4547 T14552 T14550 parataxis U,activity
R4548 T14553 T14552 nummod 170,U
R4549 T14554 T14555 punct /,mL
R4550 T14555 T14552 prep mL,U
R4551 T14556 T14557 punct ±,20
R4552 T14557 T14552 nummod 20,U
R4553 T14558 T14552 punct ", ",U
R4554 T14559 T14560 nsubj n,6
R4555 T14560 T14552 ccomp 6,U
R4556 T14561 T14560 punct =,6
R4557 T14562 T14552 punct ),U
R4558 T14563 T14532 prep in,antigen
R4559 T14564 T14565 det the,mice
R456 T3130 T3131 compound Family,history
R4560 T14565 T14563 pobj mice,in
R4561 T14566 T14565 nmod CSS,mice
R4562 T14567 T14566 punct -,CSS
R4563 T14568 T14566 nummod 11,CSS
R4564 T14569 T14536 neg not,was
R4565 T14570 T14536 acomp different,was
R4566 T14571 T14570 prep than,different
R4567 T14572 T14571 prep for,than
R4568 T14573 T14574 compound B6,mice
R4569 T14574 T14572 pobj mice,for
R457 T3131 T3132 nsubj history,is
R4570 T14575 T14536 punct .,was
R4571 T14904 T14903 prep of,Interactions
R4572 T14905 T14904 pobj CSS,of
R4573 T14906 T14903 prep for,Interactions
R4574 T14907 T14908 amod arterial,thrombus
R4575 T14908 T14909 compound thrombus,formation
R4576 T14909 T14906 pobj formation,for
R4577 T14911 T14912 det The,assay
R4578 T14912 T14915 nsubj assay,was
R4579 T14913 T14914 compound tail,bleeding
R458 T3133 T3134 punct [,1
R4580 T14914 T14912 compound bleeding,assay
R4581 T14916 T14915 acomp rapid,was
R4582 T14917 T14915 cc and,was
R4583 T14918 T14915 conj facilitated,was
R4584 T14919 T14920 det the,screening
R4585 T14920 T14918 dobj screening,facilitated
R4586 T14921 T14920 prep of,screening
R4587 T14922 T14923 det the,strains
R4588 T14923 T14921 pobj strains,of
R4589 T14924 T14923 nummod 21,strains
R459 T3134 T3131 parataxis 1,history
R4590 T14925 T14923 compound CSS,strains
R4591 T14926 T14915 punct ", ",was
R4592 T14927 T14915 cc and,was
R4593 T14928 T14929 advmod subsequently,tested
R4594 T14929 T14915 conj tested,was
R4595 T14930 T14931 det the,strains
R4596 T14931 T14929 nsubjpass strains,tested
R4597 T14932 T14931 amod identified,strains
R4598 T14933 T14929 auxpass were,tested
R4599 T14934 T14929 prep for,tested
R460 T3135 T3134 punct ],1
R4600 T14935 T14936 amod arterial,occlusion
R4601 T14936 T14934 pobj occlusion,for
R4602 T14937 T14929 prep after,tested
R4603 T14938 T14939 det the,injury
R4604 T14939 T14937 pobj injury,after
R4605 T14940 T14939 compound FeCl3,injury
R4606 T14941 T14942 punct (,Figure
R4607 T14942 T14929 parataxis Figure,tested
R4608 T14943 T14942 nummod 7,Figure
R4609 T14944 T14942 punct ),Figure
R461 T3136 T3137 det the,factor
R4610 T14945 T14929 punct .,tested
R4611 T14947 T14948 det The,CSS
R4612 T14948 T14949 nsubj CSS,had
R4613 T14950 T14948 punct -,CSS
R4614 T14951 T14948 nummod 5,CSS
R4615 T14952 T14948 cc and,CSS
R4616 T14953 T14948 conj CSS,CSS
R4617 T14954 T14953 punct -,CSS
R4618 T14955 T14953 nummod 17,CSS
R4619 T14956 T14957 compound occlusion,times
R462 T3137 T3132 attr factor,is
R4620 T14957 T14949 dobj times,had
R4621 T14958 T14957 amod similar,times
R4622 T14959 T14958 prep to,similar
R4623 T14960 T14961 det the,mice
R4624 T14961 T14959 pobj mice,to
R4625 T14962 T14961 compound B6,mice
R4626 T14963 T14949 punct ", ",had
R4627 T14964 T14949 cc but,had
R4628 T14965 T14966 det the,progeny
R4629 T14966 T14976 nsubj progeny,had
R463 T3138 T3137 amod strongest,factor
R4630 T14967 T14968 advmod doubly,heterosomic
R4631 T14968 T14966 amod heterosomic,progeny
R4632 T14969 T14966 nmod CSS,progeny
R4633 T14970 T14969 punct -,CSS
R4634 T14971 T14969 nummod 5,CSS
R4635 T14972 T14969 punct ×,CSS
R4636 T14973 T14969 appos CSS,CSS
R4637 T14974 T14973 punct -,CSS
R4638 T14975 T14973 nummod 17,CSS
R4639 T14976 T14949 conj had,had
R464 T3139 T3137 compound risk,factor
R4640 T14977 T14978 compound occlusion,times
R4641 T14978 T14976 dobj times,had
R4642 T14979 T14978 amod higher,times
R4643 T14980 T14979 prep than,higher
R4644 T14981 T14982 preconj either,mice
R4645 T14982 T14980 pobj mice,than
R4646 T14983 T14982 det the,mice
R4647 T14984 T14982 compound B6,mice
R4648 T14985 T14982 cc or,mice
R4649 T14986 T14987 det the,5F1
R465 T3140 T3137 prep for,factor
R4650 T14987 T14982 conj 5F1,mice
R4651 T14988 T14987 amod heterosomic,5F1
R4652 T14989 T14987 compound CSS,5F1
R4653 T14990 T14987 punct -,5F1
R4654 T14991 T14987 cc and,5F1
R4655 T14992 T14993 compound CSS,17F1
R4656 T14993 T14987 conj 17F1,5F1
R4657 T14994 T14993 punct -,17F1
R4658 T14995 T14987 cc or,5F1
R4659 T14996 T14997 det the,J
R466 T3141 T3142 amod cardiovascular,diseases
R4660 T14997 T15000 compound J,strains
R4661 T14998 T14997 compound A,J
R4662 T14999 T14997 punct /,J
R4663 T15000 T14987 conj strains,5F1
R4664 T15001 T14976 punct .,had
R4665 T15003 T15004 prep In,occluded
R4666 T15004 T15023 ccomp occluded,occlude
R4667 T15005 T15006 amod double,heterosomic
R4668 T15006 T15007 amod heterosomic,mice
R4669 T15007 T15003 pobj mice,In
R467 T3142 T3140 pobj diseases,for
R4670 T15008 T15007 nmod CSS,mice
R4671 T15009 T15008 punct -,CSS
R4672 T15010 T15008 nummod 5,CSS
R4673 T15011 T15008 punct ×,CSS
R4674 T15012 T15008 appos CSS,CSS
R4675 T15013 T15012 punct -,CSS
R4676 T15014 T15012 nummod 17,CSS
R4677 T15015 T15004 punct ", ",occluded
R4678 T15016 T15017 advmod only,mice
R4679 T15017 T15004 nsubj mice,occluded
R468 T3143 T3142 punct (,diseases
R4680 T15018 T15017 nummod one,mice
R4681 T15019 T15018 cc or,one
R4682 T15020 T15018 conj three,one
R4683 T15021 T15017 acl tested,mice
R4684 T15022 T15004 aux had,occluded
R4685 T15024 T15004 prep by,occluded
R4686 T15025 T15026 nummod 30,min
R4687 T15026 T15024 pobj min,by
R4688 T15027 T15023 punct ;,occlude
R4689 T15028 T15029 det the,mice
R469 T3144 T3142 appos CVD,diseases
R4690 T15029 T15023 nsubj mice,occlude
R4691 T15030 T15029 amod other,mice
R4692 T15031 T15029 nummod two,mice
R4693 T15032 T15023 aux did,occlude
R4694 T15033 T15023 neg not,occlude
R4695 T15034 T15023 prep by,occlude
R4696 T15035 T15036 nummod 30,min
R4697 T15036 T15034 pobj min,by
R4698 T15037 T15023 punct .,occlude
R4699 T15039 T15040 mark While,tested
R470 T3145 T3132 punct ),is
R4700 T15040 T15050 advcl tested,suggest
R4701 T15041 T15042 advmod only,number
R4702 T15042 T15040 nsubjpass number,tested
R4703 T15043 T15042 det a,number
R4704 T15044 T15042 amod small,number
R4705 T15045 T15042 prep of,number
R4706 T15046 T15047 compound CSS,mice
R4707 T15047 T15045 pobj mice,of
R4708 T15048 T15040 aux have,tested
R4709 T15049 T15040 auxpass been,tested
R471 T3146 T3132 punct .,is
R4710 T15051 T15040 prep for,tested
R4711 T15052 T15053 det the,occlusion
R4712 T15053 T15051 pobj occlusion,for
R4713 T15054 T15053 amod arterial,occlusion
R4714 T15055 T15050 punct ", ",suggest
R4715 T15056 T15057 det the,results
R4716 T15057 T15050 nsubj results,suggest
R4717 T15058 T15059 mark that,determines
R4718 T15059 T15050 ccomp determines,suggest
R4719 T15060 T15059 nsubj interaction,determines
R472 T3148 T3149 mark While,identified
R4720 T15061 T15060 prep of,interaction
R4721 T15062 T15063 det the,genes
R4722 T15063 T15061 pobj genes,of
R4723 T15064 T15063 prep on,genes
R4724 T15065 T15066 nmod chromosome,5
R4725 T15066 T15064 pobj 5,on
R4726 T15067 T15066 cc and,5
R4727 T15068 T15066 conj 17,5
R4728 T15069 T15059 advmod also,determines
R4729 T15070 T15071 amod arterial,occlusion
R473 T3149 T3157 advcl identified,account
R4730 T15071 T15072 compound occlusion,time
R4731 T15072 T15059 dobj time,determines
R4732 T15073 T15050 punct .,suggest
R4737 T18534 T18535 prep In,assessed
R4738 T18536 T18537 det this,study
R4739 T18537 T18534 pobj study,In
R474 T3150 T3151 det a,number
R4740 T18538 T18535 punct ", ",assessed
R4741 T18539 T18540 amod thrombotic,risk
R4742 T18540 T18535 nsubjpass risk,assessed
R4743 T18541 T18535 auxpass was,assessed
R4744 T18542 T18535 advmod systematically,assessed
R4745 T18543 T18535 prep in,assessed
R4746 T18544 T18545 nummod two,strains
R4747 T18545 T18543 pobj strains,in
R4748 T18546 T18545 amod inbred,strains
R4749 T18547 T18545 prep of,strains
R475 T3151 T3149 nsubjpass number,identified
R4750 T18548 T18547 pobj mice,of
R4751 T18549 T18550 dep that,have
R4752 T18550 T18545 relcl have,strains
R4753 T18551 T18552 amod marked,differences
R4754 T18552 T18550 dobj differences,have
R4755 T18553 T18552 prep in,differences
R4756 T18554 T18553 pobj susceptibility,in
R4757 T18555 T18554 prep to,susceptibility
R4758 T18556 T18557 npadvmod diet,induced
R4759 T18557 T18559 amod induced,obesity
R476 T3152 T3151 prep of,number
R4760 T18558 T18557 punct -,induced
R4761 T18559 T18555 pobj obesity,to
R4762 T18560 T18559 punct ", ",obesity
R4763 T18561 T18562 npadvmod diet,induced
R4764 T18562 T18564 amod induced,atherosclerosis
R4765 T18563 T18562 punct -,induced
R4766 T18564 T18559 conj atherosclerosis,obesity
R4767 T18565 T18564 punct ", ",atherosclerosis
R4768 T18566 T18564 cc and,atherosclerosis
R4769 T18567 T18568 npadvmod ligation,induced
R477 T3153 T3154 amod genetic,mutations
R4770 T18568 T18570 amod induced,hyperplasia
R4771 T18569 T18568 punct -,induced
R4772 T18570 T18564 conj hyperplasia,atherosclerosis
R4773 T18571 T18570 amod neointimal,hyperplasia
R4774 T18572 T18570 cc and,hyperplasia
R4775 T18573 T18574 compound vessel,remodeling
R4776 T18574 T18570 conj remodeling,hyperplasia
R4777 T18575 T18535 punct .,assessed
R4778 T18577 T18578 amod Arterial,occlusion
R4779 T18578 T18579 compound occlusion,time
R478 T3154 T3152 pobj mutations,of
R4780 T18579 T18580 nsubjpass time,evaluated
R4781 T18581 T18579 punct ", ",time
R4782 T18582 T18583 nmod tail,bleeding
R4783 T18583 T18584 nmod bleeding,time
R4784 T18584 T18579 appos time,time
R4785 T18585 T18583 cc and,bleeding
R4786 T18586 T18583 conj rebleeding,bleeding
R4787 T18587 T18580 auxpass were,evaluated
R4788 T18588 T18580 prep as,evaluated
R4789 T18589 T18590 amod potential,predictors
R479 T3155 T3149 aux have,identified
R4790 T18590 T18588 pobj predictors,as
R4791 T18591 T18590 prep of,predictors
R4792 T18592 T18593 amod thrombotic,response
R4793 T18593 T18591 pobj response,of
R4794 T18594 T18580 punct .,evaluated
R4795 T18596 T18597 nsubjpass Assessments,compared
R4796 T18598 T18596 prep of,Assessments
R4797 T18599 T18600 det the,strains
R4798 T18600 T18598 pobj strains,of
R4799 T18601 T18600 nummod two,strains
R480 T3156 T3149 auxpass been,identified
R4800 T18602 T18600 amod inbred,strains
R4801 T18603 T18597 auxpass were,compared
R4802 T18604 T18597 prep to,compared
R4803 T18605 T18604 pobj values,to
R4804 T18606 T18605 prep from,values
R4805 T18607 T18608 npadvmod gene,targeted
R4806 T18608 T18609 amod targeted,mice
R4807 T18609 T18606 pobj mice,from
R4808 T18610 T18609 prep of,mice
R4809 T18611 T18612 det the,network
R481 T3158 T3157 punct ", ",account
R4810 T18612 T18610 pobj network,of
R4811 T18613 T18612 compound Plg,network
R4812 T18614 T18609 prep with,mice
R4813 T18615 T18616 amod altered,responses
R4814 T18616 T18614 pobj responses,with
R4815 T18617 T18616 amod fibrinolytic,responses
R4816 T18618 T18606 punct ", ",from
R4817 T18619 T18620 advmod as,as
R4818 T18620 T18606 cc as,from
R4819 T18621 T18620 advmod well,as
R482 T3159 T3157 nsubj these,account
R4820 T18622 T18606 conj in,from
R4821 T18623 T18624 npadvmod leptin,deficient
R4822 T18624 T18625 amod deficient,mice
R4823 T18625 T18622 pobj mice,in
R4824 T18626 T18625 prep with,mice
R4825 T18627 T18628 det a,function
R4826 T18628 T18626 pobj function,with
R4827 T18629 T18628 amod reduced,function
R4828 T18630 T18628 compound platelet,function
R4829 T18631 T18597 punct .,compared
R483 T3160 T3157 prep for,account
R4830 T18633 T18634 amod Marked,differences
R4831 T18634 T18635 nsubjpass differences,found
R4832 T18636 T18635 auxpass were,found
R4833 T18637 T18635 prep in,found
R4834 T18638 T18639 det the,response
R4835 T18639 T18637 pobj response,in
R4836 T18640 T18639 amod thrombotic,response
R4837 T18641 T18635 prep among,found
R4838 T18642 T18643 det the,strains
R4839 T18643 T18641 pobj strains,among
R484 T3161 T3162 advmod only,percentage
R4840 T18644 T18643 nummod two,strains
R4841 T18645 T18643 amod inbred,strains
R4842 T18646 T18643 punct ", ",strains
R4843 T18647 T18643 appos B6,strains
R4844 T18648 T18647 cc and,B6
R4845 T18649 T18650 compound A,J
R4846 T18650 T18647 conj J,B6
R4847 T18651 T18650 punct /,J
R4848 T18652 T18635 punct ", ",found
R4849 T18653 T18635 cc and,found
R485 T3162 T3160 pobj percentage,for
R4850 T18654 T18655 det the,differences
R4851 T18655 T18657 nsubjpass differences,correlated
R4852 T18656 T18655 amod observed,differences
R4853 T18657 T18635 conj correlated,found
R4854 T18658 T18657 auxpass were,correlated
R4855 T18659 T18657 neg not,correlated
R4856 T18660 T18657 prep with,correlated
R4857 T18661 T18660 pobj change,with
R4858 T18662 T18661 prep in,change
R4859 T18663 T18662 pobj coagulation,in
R486 T3163 T3162 det a,percentage
R4860 T18664 T18663 cc or,coagulation
R4861 T18665 T18666 compound platelet,function
R4862 T18666 T18663 conj function,coagulation
R4863 T18667 T18657 punct .,correlated
R4864 T18669 T18670 csubj Screening,identified
R4865 T18671 T18672 det the,CSS
R4866 T18672 T18669 dobj CSS,Screening
R4867 T18673 T18674 nummod three,chromosomes
R4868 T18674 T18670 dobj chromosomes,identified
R4869 T18675 T18676 dep that,harbored
R487 T3164 T3162 amod small,percentage
R4870 T18676 T18674 relcl harbored,chromosomes
R4871 T18677 T18676 dobj genes,harbored
R4872 T18678 T18679 dep which,contributed
R4873 T18679 T18677 relcl contributed,genes
R4874 T18680 T18679 prep to,contributed
R4875 T18681 T18682 det the,phenotype
R4876 T18682 T18680 pobj phenotype,to
R4877 T18683 T18684 compound A,J
R4878 T18684 T18682 compound J,phenotype
R4879 T18685 T18684 punct /,J
R488 T3165 T3162 prep of,percentage
R4880 T18686 T18682 prep of,phenotype
R4881 T18687 T18688 amod increased,time
R4882 T18688 T18686 pobj time,of
R4883 T18689 T18688 compound rebleeding,time
R4884 T18690 T18670 punct .,identified
R4885 T18692 T18693 nsubjpass Mice,required
R4886 T18694 T18692 amod homosomic,Mice
R4887 T18695 T18694 prep for,homosomic
R4888 T18696 T18697 det these,chromosomes
R4889 T18697 T18695 pobj chromosomes,for
R489 T3166 T3167 det the,CVD
R4890 T18698 T18694 cc or,homosomic
R4891 T18699 T18700 advmod doubly,heterosomic
R4892 T18700 T18694 conj heterosomic,homosomic
R4893 T18701 T18700 prep for,heterosomic
R4894 T18702 T18701 pobj two,for
R4895 T18703 T18702 prep of,two
R4896 T18704 T18705 det the,chromosomes
R4897 T18705 T18703 pobj chromosomes,of
R4898 T18706 T18702 punct ", ",two
R4899 T18707 T18702 appos 5,two
R490 T3167 T3165 pobj CVD,of
R4900 T18708 T18707 cc and,5
R4901 T18709 T18707 conj 17,5
R4902 T18710 T18693 punct ", ",required
R4903 T18711 T18693 auxpass were,required
R4904 T18712 T18713 aux to,express
R4905 T18713 T18693 advcl express,required
R4906 T18714 T18715 det the,phenotype
R4907 T18715 T18713 dobj phenotype,express
R4908 T18716 T18717 compound A,J
R4909 T18717 T18715 compound J,phenotype
R491 T3168 T3167 prep in,CVD
R4910 T18718 T18717 punct /,J
R4911 T18719 T18715 punct ", ",phenotype
R4912 T18720 T18721 amod elevated,time
R4913 T18721 T18715 appos time,phenotype
R4914 T18722 T18721 compound rebleeding,time
R4915 T18723 T18693 punct .,required
R4916 T18725 T18726 nsubjpass PAI,decreased
R4917 T18727 T18725 punct -,PAI
R4918 T18728 T18725 nummod 1,PAI
R4919 T18729 T18725 appos antigen,PAI
R492 T3169 T3170 amod human,populations
R4920 T18730 T18729 cc and,antigen
R4921 T18731 T18729 conj activity,antigen
R4922 T18732 T18726 auxpass were,decreased
R4923 T18733 T18726 prep in,decreased
R4924 T18734 T18735 preconj both,CSS
R4925 T18735 T18733 pobj CSS,in
R4926 T18736 T18735 punct -,CSS
R4927 T18737 T18735 nummod 5,CSS
R4928 T18738 T18735 cc and,CSS
R4929 T18739 T18735 conj CSS,CSS
R493 T3170 T3168 pobj populations,in
R4930 T18740 T18739 punct -,CSS
R4931 T18741 T18739 nummod 17,CSS
R4932 T18742 T18735 cc and,CSS
R4933 T18743 T18744 det the,mice
R4934 T18744 T18735 conj mice,CSS
R4935 T18745 T18744 amod heterosomic,mice
R4936 T18746 T18744 punct ", ",mice
R4937 T18747 T18748 compound CSS,5F1
R4938 T18748 T18744 appos 5F1,mice
R4939 T18749 T18748 punct -,5F1
R494 T3171 T3157 punct .,account
R4940 T18750 T18748 cc and,5F1
R4941 T18751 T18752 compound CSS,17F1
R4942 T18752 T18748 conj 17F1,5F1
R4943 T18753 T18752 punct -,17F1
R4944 T18754 T18733 punct ", ",in
R4945 T18755 T18733 cc but,in
R4946 T18756 T18755 neg not,but
R4947 T18757 T18733 conj in,in
R4948 T18758 T18759 det the,strain
R4949 T18759 T18757 pobj strain,in
R495 T3173 T3174 compound Thrombus,formation
R4950 T18760 T18759 nmod CSS,strain
R4951 T18761 T18760 punct -,CSS
R4952 T18762 T18760 nummod 11,CSS
R4953 T18763 T18726 punct .,decreased
R4954 T18765 T18766 nsubjpass Values,restored
R4955 T18767 T18766 auxpass were,restored
R4956 T18768 T18766 prep in,restored
R4957 T18769 T18770 det the,heterosomic
R4958 T18770 T18768 pobj heterosomic,in
R4959 T18771 T18770 advmod doubly,heterosomic
R496 T3174 T3175 nsubj formation,is
R4960 T18772 T18766 prep for,restored
R4961 T18773 T18772 pobj two,for
R4962 T18774 T18773 prep of,two
R4963 T18775 T18774 pobj chromosomes,of
R4964 T18776 T18773 punct ", ",two
R4965 T18777 T18773 appos 5,two
R4966 T18778 T18777 cc and,5
R4967 T18779 T18777 conj 17,5
R4968 T18780 T18766 punct .,restored
R4969 T18782 T18783 amod Arterial,occlusion
R497 T3176 T3174 prep on,formation
R4970 T18783 T18784 compound occlusion,time
R4971 T18784 T18785 nsubj time,was
R4972 T18786 T18785 acomp similar,was
R4973 T18787 T18786 prep to,similar
R4974 T18788 T18787 pobj B6,to
R4975 T18789 T18785 prep in,was
R4976 T18790 T18791 det the,strains
R4977 T18791 T18789 pobj strains,in
R4978 T18792 T18791 nmod CSS,strains
R4979 T18793 T18792 punct -,CSS
R498 T3177 T3178 amod fissured,plaques
R4980 T18794 T18792 nummod 5,CSS
R4981 T18795 T18792 cc and,CSS
R4982 T18796 T18792 conj CSS,CSS
R4983 T18797 T18796 punct -,CSS
R4984 T18798 T18796 nummod 17,CSS
R4985 T18799 T18791 amod homozygous,strains
R4986 T18800 T18785 punct ", ",was
R4987 T18801 T18785 cc but,was
R4988 T18802 T18785 conj increased,was
R4989 T18803 T18802 prep in,increased
R499 T3178 T3176 pobj plaques,on
R4990 T18804 T18805 advmod doubly,heterosomic
R4991 T18805 T18803 pobj heterosomic,in
R4992 T18806 T18785 prep for,was
R4993 T18807 T18806 pobj two,for
R4994 T18808 T18807 prep of,two
R4995 T18809 T18808 pobj chromosomes,of
R4996 T18810 T18807 punct ", ",two
R4997 T18811 T18807 appos 5,two
R4998 T18812 T18811 cc and,5
R4999 T18813 T18811 conj 17,5
R500 T3179 T3178 amod atherosclerotic,plaques
R5000 T18814 T18785 punct .,was
R5001 T18816 T18817 det The,model
R5002 T18817 T18821 nsubjpass model,used
R5003 T18818 T18819 npadvmod FeCl3,induced
R5004 T18819 T18817 amod induced,model
R5005 T18820 T18819 punct -,induced
R5006 T18822 T18817 prep of,model
R5007 T18823 T18824 amod vascular,injury
R5008 T18824 T18822 pobj injury,of
R5009 T18825 T18824 cc and,injury
R501 T3180 T3181 det the,event
R5010 T18826 T18824 conj thrombosis,injury
R5011 T18827 T18817 prep in,model
R5012 T18828 T18827 pobj mice,in
R5013 T18829 T18821 auxpass is,used
R5014 T18830 T18821 advmod now,used
R5015 T18831 T18821 advmod widely,used
R5016 T18832 T18833 aux to,evaluate
R5017 T18833 T18821 advcl evaluate,used
R5018 T18834 T18835 amod genetic,interventions
R5019 T18835 T18833 dobj interventions,evaluate
R502 T3181 T3175 attr event,is
R5020 T18836 T18834 cc and,genetic
R5021 T18837 T18834 conj pharmacological,genetic
R5022 T18838 T18839 punct [,24
R5023 T18839 T18821 parataxis 24,used
R5024 T18840 T18839 punct ],24
R5025 T18841 T18821 punct .,used
R5026 T18843 T18844 det The,strains
R5027 T18844 T18847 nsubj strains,had
R5028 T18845 T18844 nummod two,strains
R5029 T18846 T18844 amod inbred,strains
R503 T3182 T3181 amod precipitating,event
R5030 T18848 T18849 amod marked,differences
R5031 T18849 T18847 dobj differences,had
R5032 T18850 T18849 prep in,differences
R5033 T18851 T18852 det the,time
R5034 T18852 T18850 pobj time,in
R5035 T18853 T18852 prep for,time
R5036 T18854 T18853 pobj occlusion,for
R5037 T18855 T18854 prep of,occlusion
R5038 T18856 T18857 det the,artery
R5039 T18857 T18855 pobj artery,of
R504 T3183 T3181 prep in,event
R5040 T18858 T18857 amod carotid,artery
R5041 T18859 T18854 prep after,occlusion
R5042 T18860 T18861 compound FeCl3,injury
R5043 T18861 T18859 pobj injury,after
R5044 T18862 T18847 punct .,had
R5045 T18864 T18865 prep After,shortened
R5046 T18866 T18867 compound FeCl3,treatment
R5047 T18867 T18864 pobj treatment,After
R5048 T18868 T18865 punct ", ",shortened
R5049 T18869 T18870 compound thrombus,formation
R505 T3184 T3185 det the,transition
R5050 T18870 T18865 nsubjpass formation,shortened
R5051 T18871 T18870 cc and,formation
R5052 T18872 T18870 conj occlusion,formation
R5053 T18873 T18865 auxpass was,shortened
R5054 T18874 T18865 advmod remarkably,shortened
R5055 T18875 T18865 prep in,shortened
R5056 T18876 T18877 det the,mice
R5057 T18877 T18875 pobj mice,in
R5058 T18878 T18879 compound A,J
R5059 T18879 T18877 compound J,mice
R506 T3185 T3183 pobj transition,in
R5060 T18880 T18879 punct /,J
R5061 T18881 T18865 prep compared,shortened
R5062 T18882 T18881 prep to,compared
R5063 T18883 T18884 det the,mice
R5064 T18884 T18882 pobj mice,to
R5065 T18885 T18884 compound B6,mice
R5066 T18886 T18865 punct .,shortened
R5067 T18888 T18889 det These,results
R5068 T18889 T18890 nsubjpass results,reported
R5069 T18891 T18890 aux have,reported
R507 T3186 T3185 prep from,transition
R5070 T18892 T18890 neg not,reported
R5071 T18893 T18890 advmod previously,reported
R5072 T18894 T18890 auxpass been,reported
R5073 T18895 T18890 punct .,reported
R5074 T18897 T18898 det A,study
R5075 T18898 T18900 nsubj study,found
R5076 T18899 T18898 amod recent,study
R5077 T18901 T18902 punct [,25
R5078 T18902 T18898 parataxis 25,study
R5079 T18903 T18902 punct ],25
R508 T3187 T3188 det a,disease
R5080 T18904 T18898 prep of,study
R5081 T18905 T18906 amod sheer,stress
R5082 T18906 T18904 pobj stress,of
R5083 T18907 T18898 prep in,study
R5084 T18908 T18907 pobj rats,in
R5085 T18909 T18900 punct ", ",found
R5086 T18910 T18911 mark that,varied
R5087 T18911 T18900 ccomp varied,found
R5088 T18912 T18913 det the,magnitude
R5089 T18913 T18911 nsubj magnitude,varied
R509 T3188 T3186 pobj disease,from
R5090 T18914 T18913 prep of,magnitude
R5091 T18915 T18914 pobj changes,of
R5092 T18916 T18915 prep in,changes
R5093 T18917 T18918 amod sheer,stress
R5094 T18918 T18916 pobj stress,in
R5095 T18919 T18913 prep with,magnitude
R5096 T18920 T18921 amod increased,flow
R5097 T18921 T18919 pobj flow,with
R5098 T18922 T18921 compound blood,flow
R5099 T18923 T18911 prep with,varied
R510 T3189 T3188 amod stable,disease
R5100 T18924 T18925 det the,strains
R5101 T18925 T18923 pobj strains,with
R5102 T18926 T18925 amod different,strains
R5103 T18927 T18900 punct .,found
R5104 T18929 T18930 amod Further,investigation
R5105 T18930 T18931 nsubj investigation,be
R5106 T18932 T18930 punct ", ",investigation
R5107 T18933 T18930 prep beyond,investigation
R5108 T18934 T18935 det the,scope
R5109 T18935 T18933 pobj scope,beyond
R511 T3190 T3189 cc or,stable
R5110 T18936 T18935 prep of,scope
R5111 T18937 T18938 det this,study
R5112 T18938 T18936 pobj study,of
R5113 T18939 T18931 aux would,be
R5114 T18940 T18931 acomp necessary,be
R5115 T18941 T18942 aux to,determine
R5116 T18942 T18931 advcl determine,be
R5117 T18943 T18944 det the,contribution
R5118 T18944 T18942 dobj contribution,determine
R5119 T18945 T18944 prep in,contribution
R512 T3191 T3189 conj subclinical,stable
R5120 T18946 T18947 det the,differences
R5121 T18947 T18945 pobj differences,in
R5122 T18948 T18947 prep in,differences
R5123 T18949 T18948 pobj size,in
R5124 T18950 T18947 cc and,differences
R5125 T18951 T18952 amod sheer,stress
R5126 T18952 T18947 conj stress,differences
R5127 T18953 T18952 prep of,stress
R5128 T18954 T18955 det the,carotids
R5129 T18955 T18953 pobj carotids,of
R513 T3192 T3188 amod atherosclerotic,disease
R5130 T18956 T18944 prep to,contribution
R5131 T18957 T18958 amod arterial,rates
R5132 T18958 T18956 pobj rates,to
R5133 T18959 T18958 compound occlusion,rates
R5134 T18960 T18958 prep in,rates
R5135 T18961 T18962 det the,mice
R5136 T18962 T18960 pobj mice,in
R5137 T18963 T18962 nmod B6,mice
R5138 T18964 T18963 cc and,B6
R5139 T18965 T18966 compound A,J
R514 T3193 T3175 cc and,is
R5140 T18966 T18963 conj J,B6
R5141 T18967 T18966 punct /,J
R5142 T18968 T18931 punct .,be
R5143 T18970 T18971 prep In,noted
R5144 T18972 T18973 amod preliminary,studies
R5145 T18973 T18970 pobj studies,In
R5146 T18974 T18971 punct ", ",noted
R5147 T18975 T18971 nsubj we,noted
R5148 T18976 T18971 aux have,noted
R5149 T18977 T18971 dobj differences,noted
R515 T3194 T3175 conj leads,is
R5150 T18978 T18977 prep in,differences
R5151 T18979 T18980 det the,composition
R5152 T18980 T18978 pobj composition,in
R5153 T18981 T18980 prep of,composition
R5154 T18982 T18983 det the,thrombus
R5155 T18983 T18981 pobj thrombus,of
R5156 T18984 T18971 prep in,noted
R5157 T18985 T18986 nmod B6,mice
R5158 T18986 T18984 pobj mice,in
R5159 T18987 T18985 cc and,B6
R516 T3195 T3194 prep to,leads
R5160 T18988 T18989 compound A,J
R5161 T18989 T18985 conj J,B6
R5162 T18990 T18989 punct /,J
R5163 T18991 T18971 punct .,noted
R5164 T18993 T18994 det The,pattern
R5165 T18994 T18995 nsubj pattern,was
R5166 T19075 T19076 det the,rate
R5167 T18996 T18994 prep of,pattern
R5168 T19076 T19074 dobj rate,affect
R5169 T19077 T19076 prep of,rate
R517 T3196 T3197 amod acute,infarction
R5170 T18997 T18998 compound blood,flow
R5171 T19078 T19079 compound clot,lysis
R5172 T19079 T19077 pobj lysis,of
R5173 T18998 T18999 compound flow,cessation
R5174 T19080 T19068 punct ", ",modulate
R5175 T19081 T19068 aux can,modulate
R5176 T19082 T19083 det the,events
R5177 T18999 T18996 pobj cessation,of
R5178 T19083 T19068 dobj events,modulate
R5179 T19084 T19083 acl leading,events
R518 T3197 T3195 pobj infarction,to
R5180 T19085 T19084 prep to,leading
R5181 T19000 T18994 prep for,pattern
R5182 T19086 T19087 amod occlusive,thrombus
R5183 T19087 T19088 compound thrombus,formation
R5184 T19001 T19002 det the,strains
R5185 T19088 T19085 pobj formation,to
R5186 T19089 T19031 punct .,reduced
R5187 T19002 T19000 pobj strains,for
R5188 T19091 T19092 det The,assay
R5189 T19092 T19096 nsubjpass assay,used
R519 T3198 T3197 amod myocardial,infarction
R5190 T19003 T19002 nummod two,strains
R5191 T19093 T19094 compound tail,bleeding
R5192 T19094 T19092 compound bleeding,assay
R5193 T19095 T19094 punct -,bleeding
R5194 T19004 T19002 amod inbred,strains
R5195 T19097 T19096 aux has,used
R5196 T19005 T18995 acomp different,was
R5197 T19098 T19096 auxpass been,used
R5198 T19006 T19005 prep than,different
R5199 T19099 T19096 advmod extensively,used
R520 T3199 T3197 punct ", ",infarction
R5200 T19100 T19096 prep in,used
R5201 T19101 T19100 pobj mice,in
R5202 T19102 T19103 aux to,assess
R5203 T19007 T19006 prep for,than
R5204 T19103 T19096 advcl assess,used
R5205 T19104 T19105 det the,impact
R5206 T19105 T19103 dobj impact,assess
R5207 T19008 T19009 det the,mice
R5208 T19106 T19105 prep of,impact
R5209 T19009 T19007 pobj mice,for
R521 T3200 T3201 amod ischemic,stroke
R5210 T19107 T19106 pobj deficiencies,of
R5211 T19108 T19107 cc and,deficiencies
R5212 T19109 T19110 advmod over,expression
R5213 T19010 T19009 compound Lepob,mice
R5214 T19110 T19107 conj expression,deficiencies
R5215 T19111 T19107 prep of,deficiencies
R5216 T19112 T19113 nmod platelet,proteins
R5217 T19011 T19012 punct [,26
R5218 T19113 T19111 pobj proteins,of
R5219 T19114 T19112 cc and,platelet
R522 T3201 T3197 conj stroke,infarction
R5220 T19012 T19009 parataxis 26,mice
R5221 T19115 T19112 conj coagulation,platelet
R5222 T19116 T19107 prep in,deficiencies
R5223 T19117 T19116 pobj mice,in
R5224 T19013 T19012 punct ],26
R5225 T19118 T19096 punct .,used
R5226 T19120 T19121 nsubj Sweeny,screened
R5227 T19014 T19009 prep with,mice
R5228 T19122 T19123 advmod et,al
R5229 T19123 T19120 advmod al,Sweeny
R523 T3202 T3201 cc or,stroke
R5230 T19015 T19016 amod impaired,function
R5231 T19124 T19125 punct [,28
R5232 T19125 T19120 parataxis 28,Sweeny
R5233 T19126 T19125 punct ],28
R5234 T19016 T19014 pobj function,with
R5235 T19127 T19128 nummod 25,strains
R5236 T19128 T19121 dobj strains,screened
R5237 T19017 T19016 compound platelet,function
R5238 T19129 T19128 prep of,strains
R5239 T19130 T19129 pobj mice,of
R524 T3203 T3204 amod peripheral,arterial
R5240 T19131 T19121 cc and,screened
R5241 T19018 T18995 punct ", ",was
R5242 T19132 T19121 conj found,screened
R5243 T19133 T19134 advmod only,mice
R5244 T19019 T18995 cc and,was
R5245 T19134 T19139 nsubj mice,have
R5246 T19135 T19134 det the,mice
R5247 T19136 T19137 compound RIIS,J
R5248 T19020 T19021 compound coagulation,time
R5249 T19137 T19134 compound J,mice
R525 T3204 T3205 amod arterial,occlusion
R5250 T19138 T19137 punct /,J
R5251 T19139 T19132 ccomp have,found
R5252 T19140 T19139 aux to,have
R5253 T19141 T19142 amod increased,time
R5254 T19142 T19139 dobj time,have
R5255 T19021 T19022 nsubj time,was
R5256 T19143 T19142 compound bleeding,time
R5257 T19144 T19142 prep due,time
R5258 T19145 T19144 pcomp to,due
R5259 T19022 T18995 conj was,was
R526 T3205 T3201 conj occlusion,stroke
R5260 T19146 T19147 amod reduced,antigen
R5261 T19147 T19144 pobj antigen,due
R5262 T19023 T19022 acomp similar,was
R5263 T19148 T19149 compound von,Willebrand
R5264 T19149 T19147 compound Willebrand,antigen
R5265 T19150 T19121 punct .,screened
R5266 T19024 T19022 prep in,was
R5267 T19152 T19153 nsubj Broze,evaluated
R5268 T19025 T19026 det the,strains
R5269 T19154 T19155 advmod et,al
R527 T3206 T3175 punct .,is
R5270 T19155 T19152 advmod al,Broze
R5271 T19026 T19024 pobj strains,in
R5272 T19156 T19157 punct [,29
R5273 T19157 T19152 parataxis 29,Broze
R5274 T19027 T19026 nummod two,strains
R5275 T19158 T19157 punct ],29
R5276 T19159 T19153 dobj mice,evaluated
R5277 T19160 T19159 prep with,mice
R5278 T19028 T19022 punct .,was
R5279 T19161 T19162 compound gene,deletions
R528 T3208 T3209 amod Arterial,thrombosis
R5280 T19162 T19160 pobj deletions,with
R5281 T19163 T19162 prep of,deletions
R5282 T19030 T19031 prep In,reduced
R5283 T19164 T19165 det the,pathway
R5284 T19165 T19163 pobj pathway,of
R5285 T19166 T19165 compound coagulation,pathway
R5286 T19167 T19153 cc and,evaluated
R5287 T19032 T19033 det the,mice
R5288 T19168 T19153 conj found,evaluated
R5289 T19169 T19170 mark that,persisted
R529 T3209 T3212 nsubj thrombosis,are
R5290 T19170 T19168 ccomp persisted,found
R5291 T19171 T19172 mark while,increased
R5292 T19033 T19030 pobj mice,In
R5293 T19172 T19170 advcl increased,persisted
R5294 T19173 T19174 compound bleeding,time
R5295 T19034 T19033 prep with,mice
R5296 T19174 T19172 nsubjpass time,increased
R5297 T19175 T19172 auxpass was,increased
R5298 T19176 T19172 neg not,increased
R5299 T19035 T19034 pobj deficiencies,with
R530 T3210 T3208 cc and,Arterial
R5300 T19177 T19170 punct ", ",persisted
R5301 T19178 T19170 nsubj rebleeding,persisted
R5302 T19036 T19035 prep of,deficiencies
R5303 T19179 T19170 prep despite,persisted
R5304 T19180 T19179 pobj electrocautery,despite
R5305 T19037 T19038 det the,network
R5306 T19038 T19036 pobj network,of
R5307 T19039 T19038 compound Plg,network
R5308 T19181 T19180 prep of,electrocautery
R5309 T19182 T19183 det the,tail
R531 T3211 T3208 conj venous,Arterial
R5310 T19040 T19041 punct [,27
R5311 T19041 T19033 parataxis 27,mice
R5312 T19183 T19181 pobj tail,of
R5313 T19042 T19041 punct ],27
R5314 T19184 T19170 prep in,persisted
R5315 T19185 T19186 npadvmod FVIII,deficient
R5316 T19186 T19189 amod deficient,mice
R5317 T19043 T19031 punct ", ",reduced
R5318 T19187 T19185 cc and,FVIII
R5319 T19188 T19185 conj FIX,FVIII
R532 T3213 T3214 amod complex,responses
R5320 T19189 T19184 pobj mice,in
R5321 T19044 T19045 compound thrombus,formation
R5322 T19190 T19153 punct .,evaluated
R5323 T19045 T19046 compound formation,time
R5324 T19192 T19193 det This,observation
R5325 T19193 T19194 nsubj observation,raised
R5326 T19046 T19031 nsubj time,reduced
R5327 T19195 T19196 det the,possibility
R5328 T19047 T19031 aux was,reduced
R5329 T19196 T19194 dobj possibility,raised
R533 T3214 T3212 attr responses,are
R5330 T19197 T19198 mark that,be
R5331 T19198 T19196 acl be,possibility
R5332 T19048 T19031 prep in,reduced
R5333 T19199 T19200 compound rebleeding,time
R5334 T19200 T19198 nsubj time,be
R5335 T19201 T19198 aux may,be
R5336 T19049 T19050 det the,mice
R5337 T19202 T19203 det a,reporter
R5338 T19203 T19198 attr reporter,be
R5339 T19204 T19203 amod sensitive,reporter
R534 T3215 T3212 cc and,are
R5340 T19050 T19048 pobj mice,in
R5341 T19205 T19203 prep of,reporter
R5342 T19206 T19207 amod genetic,influences
R5343 T19207 T19205 pobj influences,of
R5344 T19051 T19050 nmod Plg,mice
R5345 T19208 T19207 prep on,influences
R5346 T19209 T19210 compound thrombus,formation
R5347 T19210 T19208 pobj formation,on
R5348 T19052 T19051 punct -,Plg
R5349 T19211 T19210 cc and,formation
R535 T3216 T3217 auxpass are,influenced
R5350 T19212 T19210 conj stability,formation
R5351 T19213 T19194 punct .,raised
R5352 T19053 T19051 punct /,Plg
R5353 T19215 T19216 nsubj Mice,increased
R5354 T19054 T19051 punct -,Plg
R5355 T19217 T19218 dep that,are
R5356 T19218 T19215 relcl are,Mice
R5357 T19219 T19218 acomp deficient,are
R5358 T19220 T19219 prep in,deficient
R5359 T19221 T19220 pobj factors,in
R536 T3217 T3212 conj influenced,are
R5360 T19222 T19221 acl required,factors
R5361 T19055 T19031 punct ", ",reduced
R5362 T19223 T19222 prep for,required
R5363 T19224 T19225 amod normal,function
R5364 T19225 T19223 pobj function,for
R5365 T19056 T19031 cc but,reduced
R5366 T19226 T19225 compound platelet,function
R5367 T19227 T19225 punct ", ",function
R5368 T19228 T19229 compound platelet,Ib
R5369 T19057 T19031 conj increased,reduced
R537 T3218 T3217 agent by,influenced
R5370 T19229 T19225 conj Ib,function
R5371 T19230 T19229 compound glycoprotein,Ib
R5372 T19231 T19232 punct [,30
R5373 T19058 T19057 prep in,increased
R5374 T19232 T19229 parataxis 30,Ib
R5375 T19059 T19060 det the,mice
R5376 T19233 T19232 punct ],30
R5377 T19234 T19229 punct ", ",Ib
R5378 T19235 T19229 cc and,Ib
R5379 T19236 T19237 npadvmod protease,activated
R538 T3219 T3220 amod multiple,factors
R5380 T19060 T19058 pobj mice,in
R5381 T19237 T19239 amod activated,receptor
R5382 T19238 T19237 punct -,activated
R5383 T19061 T19060 nmod PAI,mice
R5384 T19239 T19229 conj receptor,Ib
R5385 T19240 T19239 punct -,receptor
R5386 T19241 T19239 nummod 4,receptor
R5387 T19062 T19061 punct -,PAI
R5388 T19242 T19222 punct ", ",required
R5389 T19243 T19244 punct [,31
R539 T3220 T3218 pobj factors,by
R5390 T19244 T19222 parataxis 31,required
R5391 T19063 T19061 punct /,PAI
R5392 T19245 T19244 punct ],31
R5393 T19246 T19216 aux have,increased
R5394 T19247 T19248 compound tail,bleeding
R5395 T19064 T19061 punct -,PAI
R5396 T19248 T19249 compound bleeding,time
R5397 T19249 T19216 dobj time,increased
R5398 T19250 T19216 punct .,increased
R5399 T19065 T19031 punct ", ",reduced
R540 T3221 T3220 amod genetic,factors
R5400 T19252 T19253 det The,deficiency
R5401 T19253 T19255 nsubj deficiency,shows
R5402 T19066 T19031 advcl suggesting,reduced
R5403 T19254 T19253 compound leptin,deficiency
R5404 T19256 T19253 prep with,deficiency
R5405 T19067 T19068 mark that,modulate
R5406 T19257 T19258 amod reduced,aggregation
R5407 T19258 T19256 pobj aggregation,with
R5408 T19259 T19258 compound platelet,aggregation
R5409 T19260 T19255 advmod clearly,shows
R541 T3222 T3221 cc and,genetic
R5410 T19261 T19262 det a,increase
R5411 T19262 T19255 dobj increase,shows
R5412 T19068 T19066 ccomp modulate,suggesting
R5413 T19263 T19262 amod marked,increase
R5414 T19264 T19262 prep in,increase
R5415 T19265 T19266 compound bleeding,time
R5416 T19266 T19264 pobj time,in
R5417 T19069 T19068 nsubj alterations,modulate
R5418 T19267 T19255 cc and,shows
R5419 T19268 T19269 det the,time
R542 T3223 T3221 conj environmental,genetic
R5420 T19070 T19069 prep in,alterations
R5421 T19071 T19072 compound plasmin,activity
R5422 T19269 T19272 nsubj time,suggests
R5423 T19270 T19269 amod increased,time
R5424 T19072 T19070 pobj activity,in
R5425 T19271 T19269 compound bleeding,time
R5426 T19272 T19255 conj suggests,shows
R5427 T19073 T19074 dep that,affect
R5428 T19273 T19269 prep in,time
R5429 T19074 T19069 relcl affect,alterations
R543 T3224 T3225 punct [,2
R5430 T19274 T19275 nmod Plg,mice
R5431 T19275 T19273 pobj mice,in
R5432 T19276 T19274 punct -,Plg
R5433 T19277 T19274 punct /,Plg
R5434 T19287 T19286 cc and,Plg
R5435 T19278 T19274 punct -,Plg
R5436 T19279 T19274 cc and,Plg
R5437 T19280 T19274 conj uPA,Plg
R5438 T19288 T19286 conj uPA,Plg
R5439 T19281 T19280 punct -,uPA
R544 T3225 T3217 parataxis 2,influenced
R5440 T19282 T19280 punct /,uPA
R5441 T19283 T19280 punct -,uPA
R5442 T19289 T19285 aux may,exert
R5443 T19284 T19285 mark that,exert
R5444 T19285 T19272 ccomp exert,suggests
R5445 T19286 T19285 nsubj Plg,exert
R5446 T19290 T19291 det an,influence
R5447 T19291 T19285 dobj influence,exert
R5448 T19292 T19291 prep on,influence
R5449 T19293 T19294 compound platelet,response
R545 T3226 T3227 punct -,5
R5450 T19393 T19377 conj had,had
R5451 T19294 T19292 pobj response,on
R5452 T19394 T19395 det an,time
R5453 T19395 T19393 dobj time,had
R5454 T19295 T19296 aux to,promote
R5455 T19396 T19395 amod increased,time
R5456 T19397 T19395 compound bleeding,time
R5457 T19398 T19395 amod similar,time
R5458 T19296 T19285 advcl promote,exert
R5459 T19399 T19398 prep to,similar
R546 T3227 T3225 prep 5,2
R5460 T19400 T19401 det the,mice
R5461 T19401 T19399 pobj mice,to
R5462 T19297 T19298 amod normal,formation
R5463 T19402 T19401 nmod Plg,mice
R5464 T19403 T19402 punct -,Plg
R5465 T19404 T19402 punct /,Plg
R5466 T19298 T19296 dobj formation,promote
R5467 T19405 T19402 punct -,Plg
R5468 T19406 T19407 punct (,J.
R5469 T19407 T19393 meta J.,had
R547 T3228 T3225 punct ],2
R5470 T19299 T19298 compound thrombus,formation
R5471 T19408 T19407 nmod Hoover,J.
R5472 T19409 T19407 punct -,J.
R5473 T19410 T19407 nmod Plow,J.
R5474 T19300 T19272 punct .,suggests
R5475 T19411 T19407 punct ", ",J.
R5476 T19412 T19407 conj A.,J.
R5477 T19413 T19412 nmod Shchurin,A.
R5478 T19302 T19303 advmod Overall,suggests
R5479 T19414 T19412 punct ", ",A.
R548 T3229 T3212 punct .,are
R5480 T19415 T19412 cc and,A.
R5481 T19416 T19412 conj E.,A.
R5482 T19417 T19416 nmod Hart,E.
R5483 T19304 T19303 punct ", ",suggests
R5484 T19418 T19416 punct ", ",E.
R5485 T19419 T19420 amod unpublished,results
R5486 T19305 T19306 det the,increase
R5487 T19420 T19416 conj results,E.
R5488 T19421 T19420 punct ),results
R5489 T19422 T19393 punct .,had
R549 T3231 T3232 nsubjpass Polymorphisms,implicated
R5490 T19306 T19303 nsubj increase,suggests
R5491 T19424 T19425 amod Increased,times
R5492 T19425 T19429 nsubjpass times,reported
R5493 T19307 T19306 amod marked,increase
R5494 T19426 T19425 nmod bleeding,times
R5495 T19427 T19426 cc or,bleeding
R5496 T19428 T19426 conj rebleeding,bleeding
R5497 T19308 T19306 prep in,increase
R5498 T19430 T19429 aux have,reported
R5499 T19431 T19429 neg not,reported
R550 T3233 T3231 cc and,Polymorphisms
R5500 T19432 T19429 auxpass been,reported
R5501 T19309 T19310 compound rebleeding,times
R5502 T19433 T19429 prep in,reported
R5503 T19434 T19433 pobj any,in
R5504 T19310 T19308 pobj times,in
R5505 T19435 T19434 prep of,any
R5506 T19436 T19437 det the,mice
R5507 T19311 T19306 acl observed,increase
R5508 T19437 T19435 pobj mice,of
R5509 T19312 T19311 prep in,observed
R551 T3234 T3231 conj mutations,Polymorphisms
R5510 T19438 T19439 compound Plg,network
R5511 T19439 T19440 npadvmod network,targeted
R5512 T19440 T19437 amod targeted,mice
R5513 T19441 T19429 punct .,reported
R5514 T19443 T19444 nsubj Matsuno,reported
R5515 T19313 T19314 amod certain,strains
R5516 T19445 T19446 advmod et,al
R5517 T19446 T19443 advmod al,Matsuno
R5518 T19314 T19312 pobj strains,in
R5519 T19447 T19448 punct [,32
R552 T3235 T3231 prep in,Polymorphisms
R5520 T19448 T19443 parataxis 32,Matsuno
R5521 T19315 T19314 compound mouse,strains
R5522 T19449 T19448 punct ],32
R5523 T19450 T19451 det no,difference
R5524 T19451 T19444 dobj difference,reported
R5525 T19316 T19317 amod genetic,factors
R5526 T19452 T19451 prep in,difference
R5527 T19453 T19454 compound bleeding,time
R5528 T19317 T19318 nsubj factors,play
R5529 T19318 T19303 advcl play,suggests
R553 T3236 T3237 compound coagulation,factors
R5530 T19454 T19452 pobj time,in
R5531 T19319 T19317 amod other,factors
R5532 T19455 T19451 prep for,difference
R5533 T19456 T19457 nmod tPA,mice
R5534 T19457 T19455 pobj mice,for
R5535 T19320 T19319 prep than,other
R5536 T19458 T19456 punct -,tPA
R5537 T19459 T19456 punct /,tPA
R5538 T19321 T19320 pobj coagulation,than
R5539 T19460 T19456 punct -,tPA
R554 T3237 T3235 pobj factors,in
R5540 T19461 T19456 punct ", ",tPA
R5541 T19462 T19456 appos uPA,tPA
R5542 T19322 T19318 aux may,play
R5543 T19463 T19462 punct -,uPA
R5544 T19464 T19462 punct /,uPA
R5545 T19465 T19462 punct -,uPA
R5546 T19323 T19324 det a,role
R5547 T19466 T19456 punct ", ",tPA
R5548 T19467 T19456 appos PAI,tPA
R5549 T19468 T19467 punct -,PAI
R555 T3238 T3237 punct ", ",factors
R5550 T19324 T19318 dobj role,play
R5551 T19469 T19467 nummod 1,PAI
R5552 T19470 T19467 punct -,PAI
R5553 T19471 T19467 punct /,PAI
R5554 T19325 T19318 prep in,play
R5555 T19472 T19467 punct -,PAI
R5556 T19473 T19457 prep compared,mice
R5557 T19474 T19473 prep to,compared
R5558 T19326 T19327 det the,stability
R5559 T19475 T19476 compound WT,mice
R556 T3239 T3240 amod fibrinolytic,factors
R5560 T19476 T19474 pobj mice,to
R5561 T19477 T19444 punct ", ",reported
R5562 T19327 T19325 pobj stability,in
R5563 T19478 T19444 cc and,reported
R5564 T19479 T19480 det the,assay
R5565 T19480 T19481 nsubj assay,was
R5566 T19481 T19444 conj was,reported
R5567 T19482 T19481 acomp similar,was
R5568 T19483 T19444 punct ", ",reported
R5569 T19328 T19327 prep of,stability
R557 T3240 T3237 conj factors,factors
R5570 T19484 T19444 cc but,reported
R5571 T19485 T19486 det the,segment
R5572 T19486 T19489 nsubj segment,was
R5573 T19487 T19488 compound tail,clip
R5574 T19329 T19330 det a,thrombus
R5575 T19488 T19486 compound clip,segment
R5576 T19489 T19444 conj was,reported
R5577 T19490 T19491 advmod considerably,shorter
R5578 T19330 T19328 pobj thrombus,of
R5579 T19491 T19489 acomp shorter,was
R558 T3241 T3240 punct ", ",factors
R5580 T19492 T19489 cc and,was
R5581 T19331 T19303 punct .,suggests
R5582 T19493 T19494 compound bleeding,times
R5583 T19494 T19495 nsubj times,reduced
R5584 T19495 T19489 conj reduced,was
R5585 T19496 T19495 prep compared,reduced
R5586 T19333 T19334 prep In,have
R5587 T19497 T19496 prep to,compared
R5588 T19498 T19499 det the,times
R5589 T19335 T19336 det the,assay
R559 T3242 T3243 compound platelet,surface
R5590 T19336 T19333 pobj assay,In
R5591 T19499 T19497 pobj times,to
R5592 T19337 T19338 compound tail,bleeding
R5593 T19500 T19499 acl reported,times
R5594 T19501 T19500 prep in,reported
R5595 T19338 T19336 compound bleeding,assay
R5596 T19502 T19503 poss our,study
R5597 T19503 T19501 pobj study,in
R5598 T19504 T19489 punct .,was
R5599 T19339 T19334 punct ", ",have
R560 T3243 T3244 compound surface,receptors
R5600 T19506 T19507 compound Bleeding,time
R5601 T19340 T19341 compound A,J
R5602 T19507 T19508 nsubjpass time,reported
R5603 T19509 T19508 aux has,reported
R5604 T19341 T19343 compound J,mice
R5605 T19510 T19508 neg not,reported
R5606 T19511 T19508 auxpass been,reported
R5607 T19342 T19341 punct /,J
R5608 T19512 T19508 advmod previously,reported
R5609 T19513 T19508 prep for,reported
R561 T3244 T3240 conj receptors,factors
R5610 T19514 T19515 nmod Plg,mice
R5611 T19343 T19334 nsubj mice,have
R5612 T19515 T19513 pobj mice,for
R5613 T19516 T19514 punct -,Plg
R5614 T19517 T19514 punct /,Plg
R5615 T19518 T19514 punct -,Plg
R5616 T19519 T19508 punct .,reported
R5617 T19344 T19334 aux did,have
R5618 T19521 T19522 nsubj We,found
R5619 T19523 T19522 aux have,found
R562 T3245 T3244 punct ", ",receptors
R5620 T19345 T19334 neg not,have
R5621 T19346 T19334 dobj changes,have
R5622 T19524 T19525 amod similar,values
R5623 T19525 T19522 dobj values,found
R5624 T19347 T19346 prep in,changes
R5625 T19526 T19525 prep for,values
R5626 T19527 T19528 nmod Plg,mice
R5627 T19348 T19349 compound bleeding,time
R5628 T19528 T19526 pobj mice,for
R5629 T19529 T19527 punct -,Plg
R563 T3246 T3247 compound methylenetetrahydrofalate,reductase
R5630 T19530 T19527 punct /,Plg
R5631 T19349 T19347 pobj time,in
R5632 T19531 T19527 punct -,Plg
R5633 T19532 T19528 prep in,mice
R5634 T19350 T19334 punct ", ",have
R5635 T19533 T19534 det a,background
R5636 T19534 T19532 pobj background,in
R5637 T19535 T19536 nummod 50,%
R5638 T19351 T19334 cc but,have
R5639 T19536 T19537 nmod %,B6
R564 T3247 T3244 conj reductase,receptors
R5640 T19537 T19534 nmod B6,background
R5641 T19538 T19537 punct :,B6
R5642 T19352 T19353 compound rebleeding,time
R5643 T19539 T19540 nummod 50,%
R5644 T19540 T19537 appos %,B6
R5645 T19353 T19354 nsubj time,was
R5646 T19541 T19540 nummod 129,%
R5647 T19542 T19543 punct (,J.
R5648 T19543 T19522 meta J.,found
R5649 T19544 T19543 nmod Hoover,J.
R565 T3248 T3247 punct ", ",reductase
R5650 T19354 T19334 conj was,have
R5651 T19545 T19543 punct -,J.
R5652 T19546 T19543 nmod Plow,J.
R5653 T19547 T19543 punct ", ",J.
R5654 T19548 T19543 conj A.,J.
R5655 T19549 T19548 nmod Shchurin,A.
R5656 T19355 T19354 acomp higher,was
R5657 T19550 T19548 punct ", ",A.
R5658 T19551 T19548 cc and,A.
R5659 T19356 T19354 prep compared,was
R566 T3249 T3250 amod endothelial,synthase
R5660 T19552 T19548 conj E.,A.
R5661 T19553 T19552 nmod Hart,E.
R5662 T19554 T19552 punct ", ",E.
R5663 T19555 T19556 amod unpublished,results
R5664 T19357 T19356 prep to,compared
R5665 T19556 T19552 conj results,E.
R5666 T19557 T19556 punct ),results
R5667 T19558 T19522 punct .,found
R5668 T19560 T19561 det The,results
R5669 T19561 T19562 nsubj results,suggest
R567 T3250 T3247 conj synthase,reductase
R5670 T19358 T19359 compound B6,mice
R5671 T19563 T19561 prep of,results
R5672 T19564 T19565 det this,study
R5673 T19359 T19357 pobj mice,to
R5674 T19565 T19563 pobj study,of
R5675 T19566 T19567 mark that,determined
R5676 T19567 T19562 advcl determined,suggest
R5677 T19360 T19354 punct .,was
R5678 T19568 T19567 preconj not,determined
R5679 T19569 T19568 advmod only,not
R568 T3251 T3252 amod nitric,oxide
R5680 T19570 T19567 auxpass is,determined
R5681 T19362 T19363 prep In,had
R5682 T19571 T19572 compound bleeding,time
R5683 T19572 T19567 nsubjpass time,determined
R5684 T19573 T19567 advmod genetically,determined
R5685 T19574 T19567 agent by,determined
R5686 T19364 T19365 poss our,study
R5687 T19575 T19574 pobj background,by
R5688 T19576 T19567 punct ", ",determined
R5689 T19577 T19567 cc but,determined
R569 T3252 T3250 compound oxide,synthase
R5690 T19578 T19577 advmod also,but
R5691 T19365 T19362 pobj study,In
R5692 T19579 T19580 mark that,determined
R5693 T19580 T19567 conj determined,determined
R5694 T19366 T19363 punct ", ",had
R5695 T19581 T19582 compound tail,rebleeding
R5696 T19582 T19583 compound rebleeding,time
R5697 T19583 T19580 nsubjpass time,determined
R5698 T19367 T19368 nmod Plg,mice
R5699 T19584 T19580 auxpass is,determined
R570 T3253 T3250 punct ", ",synthase
R5700 T19585 T19580 advmod genetically,determined
R5701 T19586 T19562 punct .,suggest
R5702 T19368 T19363 nsubj mice,had
R5703 T19588 T19589 mark While,be
R5704 T19369 T19367 punct -,Plg
R5705 T19589 T19594 advcl be,suggest
R5706 T19590 T19591 compound blood,pressure
R5707 T19591 T19589 nsubj pressure,be
R5708 T19370 T19367 punct /,Plg
R5709 T19592 T19589 aux could,be
R571 T3254 T3250 cc and,synthase
R5710 T19593 T19589 advmod conceivably,be
R5711 T19371 T19367 punct -,Plg
R5712 T19595 T19589 acomp higher,be
R5713 T19596 T19589 prep in,be
R5714 T19597 T19596 pobj mice,in
R5715 T19372 T19373 amod increased,time
R5716 T19598 T19597 prep with,mice
R5717 T19599 T19600 amod elevated,time
R5718 T19600 T19598 pobj time,with
R5719 T19601 T19602 compound tail,bleeding
R572 T3255 T3256 amod antioxidant,enzymes
R5720 T19602 T19600 compound bleeding,time
R5721 T19603 T19594 punct ", ",suggest
R5722 T19373 T19363 dobj time,had
R5723 T19604 T19605 amod several,studies
R5724 T19374 T19373 compound bleeding,time
R5725 T19375 T19363 punct ", ",had
R5726 T19376 T19377 nsubj PAI,had
R5727 T19605 T19594 nsubj studies,suggest
R5728 T19377 T19363 conj had,had
R5729 T19606 T19607 mark that,is
R573 T3256 T3250 conj enzymes,synthase
R5730 T19378 T19376 punct -,PAI
R5731 T19379 T19376 nummod 1,PAI
R5732 T19607 T19594 ccomp is,suggest
R5733 T19608 T19607 nsubj this,is
R5734 T19380 T19376 punct -,PAI
R5735 T19609 T19607 neg not,is
R5736 T19610 T19611 det the,case
R5737 T19611 T19607 attr case,is
R5738 T19381 T19376 punct /,PAI
R5739 T19612 T19594 punct .,suggest
R574 T3257 T3232 aux have,implicated
R5740 T19382 T19376 punct -,PAI
R5741 T19614 T19615 nsubj Studies,reported
R5742 T19383 T19384 amod decreased,time
R5743 T19616 T19614 prep of,Studies
R5744 T19617 T19618 nmod A,J
R5745 T19384 T19377 dobj time,had
R5746 T19618 T19620 nmod J,mice
R5747 T19619 T19618 punct /,J
R5748 T19385 T19384 compound rebleeding,time
R5749 T19620 T19616 pobj mice,of
R575 T3258 T3232 auxpass been,implicated
R5750 T19621 T19622 punct [,33
R5751 T19622 T19618 parataxis 33,J
R5752 T19386 T19377 punct ", ",had
R5753 T19623 T19624 punct -,36
R5754 T19624 T19622 prep 36,33
R5755 T19387 T19377 cc and,had
R5756 T19625 T19622 punct ],33
R5757 T19626 T19615 aux have,reported
R5758 T19627 T19628 preconj either,pressure
R5759 T19388 T19389 nmod uPA,mice
R576 T3259 T3232 prep as,implicated
R5760 T19628 T19615 dobj pressure,reported
R5761 T19629 T19628 amod decreased,pressure
R5762 T19389 T19393 nsubj mice,had
R5763 T19630 T19628 compound blood,pressure
R5764 T19631 T19628 cc or,pressure
R5765 T19632 T19633 det no,difference
R5766 T19390 T19388 punct -,uPA
R5767 T19633 T19628 conj difference,pressure
R5768 T19634 T19628 prep compared,pressure
R5769 T19635 T19634 prep to,compared
R577 T3260 T3261 amod genetic,determinants
R5770 T19636 T19637 det the,mice
R5771 T19637 T19635 pobj mice,to
R5772 T19638 T19637 compound B6,mice
R5773 T19391 T19388 punct /,uPA
R5774 T19639 T19615 punct .,reported
R5775 T19392 T19388 punct -,uPA
R5776 T19641 T19642 compound Blood,pressure
R5777 T19642 T19643 nsubjpass pressure,measured
R5778 T19711 T19709 pobj pressure,between
R5779 T19644 T19643 auxpass was,measured
R578 T3261 T3259 pobj determinants,as
R5780 T19645 T19643 prep in,measured
R5781 T19646 T19647 det the,mice
R5782 T19647 T19645 pobj mice,in
R5783 T19648 T19647 nmod Plg,mice
R5784 T19712 T19711 cc and,pressure
R5785 T19649 T19648 punct -,Plg
R5786 T19650 T19648 punct /,Plg
R5787 T19651 T19648 punct -,Plg
R5788 T19713 T19714 nmod tail,times
R5789 T19652 T19653 punct (,D.
R579 T3262 T3261 prep of,determinants
R5790 T19653 T19643 meta D.,measured
R5791 T19654 T19653 nmod Hellard,D.
R5792 T19714 T19711 conj times,pressure
R5793 T19655 T19653 punct ", ",D.
R5794 T19656 T19653 conj J.,D.
R5795 T19657 T19656 nmod Hoover,J.
R5796 T19715 T19714 nmod bleeding,times
R5797 T19658 T19656 punct -,J.
R5798 T19659 T19656 nmod Plow,J.
R5799 T19716 T19715 cc or,bleeding
R580 T3263 T3262 pobj susceptibility,of
R5800 T19660 T19656 punct ", ",J.
R5801 T19661 T19656 cc and,J.
R5802 T19662 T19656 conj E.,J.
R5803 T19717 T19715 conj rebleeding,bleeding
R5804 T19663 T19662 nmod Plow,E.
R5805 T19664 T19662 punct ", ",E.
R5806 T19665 T19666 amod unpublished,results
R5807 T19718 T19706 punct .,is
R5808 T19666 T19662 conj results,E.
R5809 T19667 T19666 punct ),results
R581 T3264 T3263 prep to,susceptibility
R5810 T19668 T19643 punct ", ",measured
R5811 T19720 T19721 amod Morphometric,analysis
R5812 T19669 T19643 cc and,measured
R5813 T19670 T19671 det these,mice
R5814 T19671 T19672 nsubj mice,have
R5815 T19672 T19643 conj have,measured
R5816 T19721 T19722 nsubj analysis,indicated
R5817 T19673 T19674 amod reduced,pressure
R5818 T19674 T19672 dobj pressure,have
R5819 T19675 T19674 compound blood,pressure
R582 T3265 T3264 pobj thrombosis,to
R5820 T19723 T19721 prep of,analysis
R5821 T19676 T19677 advmod when,compared
R5822 T19677 T19672 advcl compared,have
R5823 T19678 T19677 prep to,compared
R5824 T19679 T19680 amod WT,littermates
R5825 T19680 T19678 pobj littermates,to
R5826 T19681 T19672 punct ", ",have
R5827 T19682 T19672 cc and,have
R5828 T19724 T19725 det the,tail
R5829 T19683 T19684 nmod uPA,mice
R583 T3266 T3267 punct [,7
R5830 T19725 T19723 pobj tail,of
R5831 T19684 T19698 nsubj mice,have
R5832 T19685 T19683 punct -,uPA
R5833 T19726 T19727 det a,difference
R5834 T19686 T19683 punct /,uPA
R5835 T19687 T19683 punct -,uPA
R5836 T19688 T19689 punct [,37
R5837 T19689 T19683 parataxis 37,uPA
R5838 T19727 T19722 dobj difference,indicated
R5839 T19690 T19689 punct ],37
R584 T3267 T3232 parataxis 7,implicated
R5840 T19691 T19683 cc and,uPA
R5841 T19728 T19727 prep in,difference
R5842 T19692 T19683 conj Lepob,uPA
R5843 T19693 T19694 punct [,39
R5844 T19694 T19692 parataxis 39,Lepob
R5845 T19729 T19730 det the,content
R5846 T19695 T19694 nummod 38,39
R5847 T19696 T19694 punct ",",39
R5848 T19697 T19694 punct ],39
R5849 T19730 T19728 pobj content,in
R585 T3268 T3267 nummod 6,7
R5850 T19698 T19672 conj have,have
R5851 T19699 T19698 advmod also,have
R5852 T19700 T19701 amod reduced,pressure
R5853 T19731 T19730 compound collagen,content
R5854 T19701 T19698 dobj pressure,have
R5855 T19702 T19701 compound blood,pressure
R5856 T19703 T19643 punct ", ",measured
R5857 T19732 T19730 prep of,content
R5858 T19704 T19643 cc but,measured
R5859 T19705 T19706 expl there,is
R586 T3269 T3267 punct ",",7
R5860 T19706 T19643 conj is,measured
R5861 T19733 T19734 det the,tail
R5862 T19707 T19708 det no,correspondence
R5863 T19708 T19706 attr correspondence,is
R5864 T19734 T19732 pobj tail,of
R5865 T19709 T19708 prep between,correspondence
R5866 T19710 T19711 compound blood,pressure
R5867 T19735 T19727 prep in,difference
R5868 T19736 T19737 det the,mice
R5869 T19737 T19735 pobj mice,in
R587 T3270 T3267 punct ],7
R5870 T19738 T19739 compound A,J
R5871 T19817 T19815 pobj J,in
R5872 T19818 T19817 compound A,J
R5873 T19739 T19737 compound J,mice
R5874 T19819 T19817 punct /,J
R5875 T19820 T19817 appos mice,J
R5876 T19821 T19820 cc and,mice
R5877 T19822 T19820 conj CSS,mice
R5878 T19823 T19781 punct .,reside
R5879 T19740 T19739 punct /,J
R588 T3271 T3232 punct .,implicated
R5880 T19825 T19826 nsubj It,is
R5881 T19827 T19826 neg not,is
R5882 T19828 T19826 acomp likely,is
R5883 T19741 T19722 punct .,indicated
R5884 T19829 T19830 mark that,explains
R5885 T19830 T19826 ccomp explains,is
R5886 T19743 T19744 nsubj Differences,contribute
R5887 T19831 T19832 advmod merely,concentration
R5888 T19832 T19830 nsubj concentration,explains
R5889 T19833 T19832 det the,concentration
R589 T3273 T3274 amod Great,strides
R5890 T19834 T19832 prep of,concentration
R5891 T19835 T19836 det these,components
R5892 T19836 T19834 pobj components,of
R5893 T19745 T19743 prep in,Differences
R5894 T19837 T19838 det the,time
R5895 T19838 T19830 dobj time,explains
R5896 T19839 T19838 amod increased,time
R5897 T19746 T19747 det the,structure
R5898 T19747 T19745 pobj structure,in
R5899 T19840 T19838 compound rebleeding,time
R590 T3274 T3275 nsubjpass strides,made
R5900 T19748 T19747 cc and,structure
R5901 T19841 T19838 cc and,time
R5902 T19842 T19843 amod reduced,time
R5903 T19749 T19748 punct /,and
R5904 T19843 T19838 conj time,time
R5905 T19844 T19845 amod arterial,occlusion
R5906 T19845 T19843 compound occlusion,time
R5907 T19750 T19748 cc or,and
R5908 T19846 T19838 prep in,time
R5909 T19847 T19848 det the,mice
R591 T3276 T3275 aux have,made
R5910 T19751 T19747 conj metabolism,structure
R5911 T19848 T19846 pobj mice,in
R5912 T19849 T19850 compound A,J
R5913 T19850 T19848 compound J,mice
R5914 T19752 T19747 prep of,structure
R5915 T19851 T19850 punct /,J
R5916 T19852 T19826 punct .,is
R5917 T19753 T19752 pobj collagen,of
R5918 T19854 T19855 advmod When,compared
R5919 T19855 T19856 advcl compared,had
R592 T3277 T3275 auxpass been,made
R5920 T19754 T19753 cc or,collagen
R5921 T19857 T19855 prep to,compared
R5922 T19858 T19859 det the,mice
R5923 T19755 T19756 amod extracellular,proteins
R5924 T19859 T19857 pobj mice,to
R5925 T19860 T19859 compound B6,mice
R5926 T19861 T19856 punct ", ",had
R5927 T19756 T19753 conj proteins,collagen
R5928 T19862 T19863 det the,mice
R5929 T19863 T19856 nsubj mice,had
R593 T3278 T3275 prep in,made
R5930 T19864 T19865 compound A,J
R5931 T19757 T19756 compound matrix,proteins
R5932 T19865 T19863 compound J,mice
R5933 T19866 T19865 punct /,J
R5934 T19867 T19863 cc and,mice
R5935 T19758 T19744 aux may,contribute
R5936 T19868 T19869 det the,strains
R5937 T19869 T19863 conj strains,mice
R5938 T19870 T19869 nummod three,strains
R5939 T19759 T19744 prep to,contribute
R594 T3279 T3280 det the,diagnosis
R5940 T19871 T19863 prep with,mice
R5941 T19872 T19873 amod elevated,time
R5942 T19760 T19761 det the,time
R5943 T19873 T19871 pobj time,with
R5944 T19874 T19873 compound rebleeding,time
R5945 T19875 T19876 amod variable,Plg
R5946 T19761 T19759 pobj time,to
R5947 T19876 T19856 dobj Plg,had
R5948 T19877 T19876 punct ", ",Plg
R5949 T19762 T19763 amod increased,rebleeding
R595 T3280 T3278 pobj diagnosis,in
R5950 T19878 T19876 conj PAI,Plg
R5951 T19879 T19878 punct -,PAI
R5952 T19880 T19878 nummod 1,PAI
R5953 T19881 T19878 punct ", ",PAI
R5954 T19763 T19761 nmod rebleeding,time
R5955 T19882 T19878 cc and,PAI
R5956 T19883 T19884 compound α2,antiplasmin
R5957 T19884 T19878 conj antiplasmin,PAI
R5958 T19764 T19763 cc and,rebleeding
R5959 T19885 T19884 punct -,antiplasmin
R596 T3281 T3280 cc and,diagnosis
R5960 T19886 T19856 punct .,had
R5961 T19765 T19766 nmod reduced,occlusion
R5962 T19888 T19889 nummod Two,forms
R5963 T19889 T19891 nsubjpass forms,reported
R5964 T19766 T19763 conj occlusion,rebleeding
R5965 T19890 T19889 amod allelic,forms
R5966 T19892 T19889 prep of,forms
R5967 T19767 T19744 prep in,contribute
R5968 T19893 T19894 det the,gene
R5969 T19894 T19892 pobj gene,of
R597 T3282 T3280 conj treatment,diagnosis
R5970 T19768 T19769 det the,mice
R5971 T19895 T19894 compound mouse,gene
R5972 T19896 T19894 compound Plg,gene
R5973 T19897 T19891 aux have,reported
R5974 T19898 T19891 auxpass been,reported
R5975 T19769 T19767 pobj mice,in
R5976 T19899 T19891 prep for,reported
R5977 T19900 T19901 nmod B6,mice
R5978 T19901 T19899 pobj mice,for
R5979 T19902 T19900 cc and,B6
R598 T3283 T3280 prep of,diagnosis
R5980 T19903 T19904 compound A,J
R5981 T19770 T19771 compound A,J
R5982 T19904 T19900 conj J,B6
R5983 T19905 T19904 punct /,J
R5984 T19906 T19907 punct [,40
R5985 T19907 T19891 parataxis 40,reported
R5986 T19771 T19769 compound J,mice
R5987 T19908 T19907 punct ],40
R5988 T19909 T19891 punct .,reported
R5989 T19772 T19771 punct /,J
R599 T3284 T3283 pobj thrombosis,of
R5990 T19911 T19912 compound Plg,concentration
R5991 T19912 T19913 nsubjpass concentration,increased
R5992 T19773 T19744 cc and,contribute
R5993 T19914 T19913 auxpass was,increased
R5994 T19915 T19913 prep in,increased
R5995 T19774 T19744 conj warrant,contribute
R5996 T19916 T19917 compound A,J
R5997 T19917 T19919 compound J,mice
R5998 T19918 T19917 punct /,J
R5999 T19775 T19776 amod further,investigation
R600 T3285 T3275 prep in,made
R6000 T19919 T19915 pobj mice,in
R6001 T19920 T19913 prep compared,increased
R6002 T19921 T19920 prep to,compared
R6003 T19776 T19774 dobj investigation,warrant
R6004 T19922 T19923 compound B6,mice
R6005 T19777 T19744 punct .,contribute
R6006 T19779 T19780 det The,genes
R6007 T19923 T19921 pobj mice,to
R6008 T19924 T19913 punct .,increased
R6009 T19780 T19781 nsubj genes,reside
R601 T3286 T3287 det the,decade
R6010 T19926 T19927 mark Although,detect
R6011 T19782 T19780 prep for,genes
R6012 T19927 T19931 advcl detect,exclude
R6013 T19928 T19927 nsubj we,detect
R6014 T19929 T19927 aux did,detect
R6015 T19930 T19927 neg not,detect
R6016 T19783 T19782 pobj Plg,for
R6017 T19932 T19927 dobj differences,detect
R6018 T19784 T19783 punct ", ",Plg
R6019 T19933 T19932 prep in,differences
R602 T3287 T3285 pobj decade,in
R6020 T19934 T19935 compound Plg,structure
R6021 T19935 T19933 pobj structure,in
R6022 T19936 T19931 punct ", ",exclude
R6023 T19785 T19783 conj PAI,Plg
R6024 T19937 T19931 nsubj this,exclude
R6025 T19938 T19931 aux would,exclude
R6026 T19786 T19785 punct -,PAI
R6027 T19939 T19931 neg not,exclude
R6028 T19940 T19941 amod possible,differences
R6029 T19941 T19931 dobj differences,exclude
R603 T3288 T3287 amod last,decade
R6030 T19942 T19941 amod functional,differences
R6031 T19943 T19931 punct .,exclude
R6032 T19787 T19785 nummod 1,PAI
R6033 T19945 T19946 det A,strain
R6034 T19946 T19948 nsubjpass strain,tested
R6035 T19947 T19946 amod congenic,strain
R6036 T19788 T19785 punct ", ",PAI
R6037 T19949 T19946 punct (,strain
R6038 T19789 T19785 cc and,PAI
R6039 T19950 T19946 amod specific,strain
R604 T3289 T3275 punct .,made
R6040 T19790 T19791 compound α2,antiplasmin
R6041 T19951 T19950 prep for,specific
R6042 T19952 T19953 det a,region
R6043 T19953 T19951 pobj region,for
R6044 T19791 T19785 conj antiplasmin,PAI
R6045 T19954 T19953 amod homosomic,region
R6046 T19955 T19953 prep from,region
R6047 T19956 T19957 compound A,J
R6048 T19792 T19791 punct -,antiplasmin
R6049 T19957 T19955 pobj J,from
R605 T3291 T3292 advmod However,lagged
R6050 T19958 T19957 punct /,J
R6051 T19793 T19781 prep on,reside
R6052 T19959 T19957 cc and,J
R6053 T19960 T19961 det the,Chr
R6054 T19961 T19957 conj Chr,J
R6055 T19794 T19795 det the,chromosomes
R6056 T19962 T19961 amod remaining,Chr
R6057 T19963 T19964 cc and,is
R6058 T19964 T19953 parataxis is,region
R6059 T19795 T19793 pobj chromosomes,on
R606 T3293 T3292 punct ", ",lagged
R6060 T19965 T19964 nsubj background,is
R6061 T19966 T19964 prep from,is
R6062 T19967 T19968 compound B6,mice
R6063 T19796 T19795 nummod three,chromosomes
R6064 T19968 T19966 pobj mice,from
R6065 T19969 T19964 punct ),is
R6066 T19970 T19946 prep of,strain
R6067 T19797 T19795 acl identified,chromosomes
R6068 T19971 T19972 compound A,J
R6069 T19972 T19974 compound J,chromosome
R607 T3294 T3292 nsubj strategies,lagged
R6070 T19798 T19797 prep for,identified
R6071 T19973 T19972 punct /,J
R6072 T19974 T19970 pobj chromosome,of
R6073 T19975 T19974 nummod 17,chromosome
R6074 T19799 T19798 pobj QTL,for
R6075 T19976 T19977 dep that,includes
R6076 T19977 T19946 relcl includes,strain
R6077 T19978 T19979 det the,gene
R6078 T19800 T19799 prep for,QTL
R6079 T19979 T19977 dobj gene,includes
R608 T3295 T3296 aux to,prevent
R6080 T19980 T19979 compound Plg,gene
R6081 T19981 T19948 auxpass was,tested
R6082 T19982 T19948 prep in,tested
R6083 T19983 T19984 det the,assay
R6084 T19984 T19982 pobj assay,in
R6085 T19801 T19802 compound rebleeding,time
R6086 T19985 T19984 compound bleeding,assay
R6087 T19986 T19948 punct .,tested
R6088 T19802 T19800 pobj time,for
R6089 T19988 T19989 nsubj Values,were
R609 T3296 T3294 advcl prevent,strategies
R6090 T19990 T19988 prep for,Values
R6091 T19803 T19781 cc and,reside
R6092 T19991 T19990 pobj bleeding,for
R6093 T19992 T19991 cc and,bleeding
R6094 T19993 T19991 conj rebleeding,bleeding
R6095 T19804 T19781 conj may,reside
R6096 T19994 T19988 prep in,Values
R6097 T19995 T19996 det this,strain
R6098 T19996 T19994 pobj strain,in
R6099 T19805 T19804 cc or,may
R610 T3297 T3296 dobj thrombosis,prevent
R6100 T19997 T19996 amod congenic,strain
R6101 T19998 T19989 acomp similar,were
R6102 T19999 T19998 prep to,similar
R6103 T19806 T19804 conj may,may
R6104 T20000 T19999 pobj values,to
R6105 T20001 T20000 prep from,values
R6106 T20002 T20003 compound B6,mice
R6107 T19807 T19806 neg not,may
R6108 T20003 T20001 pobj mice,from
R6109 T20004 T19989 punct ", ",were
R611 T3298 T3292 aux have,lagged
R6110 T20005 T19989 advcl indicating,were
R6111 T19808 T19806 dep be,may
R6112 T20006 T20007 mark that,is
R6113 T20007 T20005 ccomp is,indicating
R6114 T20008 T20009 det the,QTL
R6115 T19809 T19808 acomp coincidental,be
R6116 T20009 T20007 nsubj QTL,is
R6117 T20010 T20007 neg not,is
R6118 T20011 T20007 attr Plg,is
R6119 T19810 T19809 prep to,coincidental
R612 T3299 T3300 advmod far,behind
R6120 T20012 T19989 punct .,were
R6121 T20014 T20015 expl There,are
R6122 T19811 T19812 det the,phenotypes
R6123 T20016 T20015 attr genes,are
R6124 T20017 T20016 prep for,genes
R6125 T19812 T19810 pobj phenotypes,to
R6126 T20018 T20019 amod other,proteases
R6127 T20019 T20017 pobj proteases,for
R6128 T19813 T19812 amod observed,phenotypes
R6129 T20020 T20019 cc and,proteases
R613 T3300 T3292 advmod behind,lagged
R6130 T20021 T20022 compound matrix,proteins
R6131 T20022 T20019 conj proteins,proteases
R6132 T19814 T19812 acl found,phenotypes
R6133 T20023 T20024 dep that,reside
R6134 T20024 T20019 relcl reside,proteases
R6135 T20025 T20024 prep on,reside
R6136 T20026 T20025 pobj chromosome,on
R6137 T20027 T20026 nummod 17,chromosome
R6138 T20028 T20015 prep in,are
R6139 T19815 T19814 prep in,found
R614 T3301 T3292 prep due,lagged
R6140 T19816 T19817 det the,J
R6141 T20135 T20134 prep in,time
R6142 T20029 T20028 pobj addition,in
R6143 T20030 T20029 prep to,addition
R6144 T20031 T20032 amod unknown,genes
R6145 T20032 T20030 pobj genes,to
R6146 T20136 T20137 det a,assay
R6147 T20033 T20015 punct .,are
R6148 T20137 T20135 pobj assay,in
R6149 T20035 T20036 compound DNA,data
R615 T3302 T3301 punct ", ",due
R6150 T20138 T20139 compound tail,bleeding
R6151 T20036 T20040 nsubj data,reported
R6152 T20037 T20038 compound base,sequence
R6153 T20139 T20137 compound bleeding,assay
R6154 T20038 T20036 compound sequence,data
R6155 T20039 T20038 compound pair,sequence
R6156 T20140 T20134 punct ", ",time
R6157 T20041 T20036 prep for,data
R6158 T20042 T20043 det the,gene
R6159 T20141 T20142 compound plasminogen,function
R616 T3303 T3301 prep in,due
R6160 T20043 T20041 pobj gene,for
R6161 T20044 T20043 nmod PAI,gene
R6162 T20142 T20134 conj function,time
R6163 T20045 T20044 punct -,PAI
R6164 T20046 T20044 nummod 1,PAI
R6165 T20143 T20142 punct ", ",function
R6166 T20144 T20142 cc and,function
R6167 T20047 T20043 cc or,gene
R6168 T20145 T20146 nmod tissue,deposition
R6169 T20048 T20049 det the,gene
R617 T3304 T3303 amod part,in
R6170 T20049 T20043 conj gene,gene
R6171 T20146 T20142 conj deposition,function
R6172 T20050 T20051 compound α2,antiplasmin
R6173 T20051 T20049 compound antiplasmin,gene
R6174 T20052 T20051 punct -,antiplasmin
R6175 T20147 T20145 cc and,tissue
R6176 T20053 T20036 prep in,data
R6177 T20054 T20055 nmod B6,mice
R6178 T20148 T20145 conj vessel,tissue
R6179 T20055 T20053 pobj mice,in
R618 T3305 T3301 punct ", ",due
R6180 T20056 T20054 cc and,B6
R6181 T20057 T20058 compound A,J
R6182 T20058 T20054 conj J,B6
R6183 T20149 T20146 compound collagen,deposition
R6184 T20059 T20058 punct /,J
R6185 T20060 T20040 aux have,reported
R6186 T20061 T20062 det no,differences
R6187 T20062 T20040 dobj differences,reported
R6188 T20063 T20064 punct [,51
R6189 T20064 T20040 parataxis 51,reported
R619 T3306 T3301 pcomp to,due
R6190 T20150 T20102 punct .,reports
R6191 T20065 T20064 punct ],51
R6192 T20066 T20040 punct ", ",reported
R6193 T20067 T20040 cc but,reported
R6194 T20152 T20153 nummod Three,chromosomes
R6195 T20068 T20069 amod regulatory,genes
R6196 T20069 T20070 nsubj genes,be
R6197 T20070 T20040 conj be,reported
R6198 T20071 T20069 advmod upstream,genes
R6199 T20153 T20154 nsubjpass chromosomes,identified
R620 T3307 T3308 det the,contribution
R6200 T20072 T20071 prep of,upstream
R6201 T20073 T20074 det the,region
R6202 T20074 T20072 pobj region,of
R6203 T20155 T20153 prep from,chromosomes
R6204 T20075 T20074 amod coding,region
R6205 T20076 T20070 aux may,be
R6206 T20077 T20070 acomp important,be
R6207 T20078 T20070 punct .,be
R6208 T20156 T20157 compound A,J
R6209 T20080 T20081 poss Our,results
R621 T3308 T3301 pobj contribution,due
R6210 T20081 T20082 nsubj results,suggest
R6211 T20157 T20159 compound J,mice
R6212 T20083 T20084 mark that,interact
R6213 T20084 T20082 ccomp interact,suggest
R6214 T20158 T20157 punct /,J
R6215 T20085 T20086 amod novel,genes
R6216 T20086 T20084 nsubj genes,interact
R6217 T20087 T20085 cc or,novel
R6218 T20159 T20155 pobj mice,from
R6219 T20088 T20085 conj unknown,novel
R622 T3309 T3308 prep of,contribution
R6220 T20089 T20084 aux may,interact
R6221 T20090 T20084 prep with,interact
R6222 T20160 T20154 auxpass were,identified
R6223 T20091 T20092 det the,components
R6224 T20092 T20090 pobj components,with
R6225 T20093 T20094 compound Plg,system
R6226 T20161 T20162 dep that,had
R6227 T20094 T20092 compound system,components
R6228 T20095 T20096 aux to,modify
R6229 T20096 T20084 advcl modify,interact
R623 T3310 T3311 amod multiple,factors
R6230 T20162 T20154 ccomp had,identified
R6231 T20097 T20098 poss their,function
R6232 T20098 T20096 dobj function,modify
R6233 T20099 T20082 punct .,suggest
R6234 T20163 T20162 dobj QTL,had
R6235 T20101 T20102 prep In,reports
R6236 T20164 T20163 prep for,QTL
R6237 T20103 T20101 pobj summary,In
R6238 T20104 T20102 punct ", ",reports
R6239 T20105 T20106 det this,study
R624 T3311 T3309 pobj factors,of
R6240 T20106 T20102 nsubj study,reports
R6241 T20107 T20108 amod marked,differences
R6242 T20108 T20102 dobj differences,reports
R6243 T20165 T20166 compound rebleeding,time
R6244 T20109 T20108 prep in,differences
R6245 T20110 T20111 nummod two,strains
R6246 T20111 T20109 pobj strains,in
R6247 T20112 T20111 amod inbred,strains
R6248 T20166 T20164 pobj time,for
R6249 T20113 T20111 prep of,strains
R625 T3312 T3310 punct ", ",multiple
R6250 T20114 T20113 pobj mice,of
R6251 T20115 T20111 punct ", ",strains
R6252 T20167 T20154 punct .,identified
R6253 T20116 T20111 appos B6,strains
R6254 T20117 T20116 cc and,B6
R6255 T20118 T20119 compound A,J
R6256 T20169 T20170 det The,genes
R6257 T20119 T20116 conj J,B6
R6258 T20120 T20119 punct /,J
R6259 T20170 T20171 nsubj genes,interact
R626 T3313 T3310 cc and,multiple
R6260 T20172 T20171 aux may,interact
R6261 T20121 T20108 punct ", ",differences
R6262 T20122 T20108 prep in,differences
R6263 T20123 T20124 amod arterial,thrombosis
R6264 T20124 T20125 compound thrombosis,formation
R6265 T20173 T20171 prep with,interact
R6266 T20125 T20122 pobj formation,in
R6267 T20126 T20125 prep in,formation
R6268 T20127 T20128 det a,model
R6269 T20174 T20173 pobj components,with
R627 T3314 T3315 advmod as,yet
R6270 T20128 T20126 pobj model,in
R6271 T20175 T20174 prep in,components
R6272 T20129 T20128 nmod FeCl3,model
R6273 T20130 T20131 amod vascular,injury
R6274 T20131 T20128 compound injury,model
R6275 T20132 T20125 punct ", ",formation
R6276 T20176 T20177 det the,network
R6277 T20133 T20134 compound rebleeding,time
R6278 T20134 T20125 conj time,formation
R6279 T20177 T20175 pobj network,in
R628 T3315 T3316 advmod yet,undefined
R6280 T20178 T20177 compound Plg,network
R6281 T20179 T20171 cc and,interact
R6282 T20180 T20171 conj modulate,interact
R6283 T20181 T20182 amod arterial,occlusion
R6284 T20182 T20183 compound occlusion,time
R6285 T20183 T20180 dobj time,modulate
R6286 T20184 T20171 punct .,interact
R6287 T20400 T20401 det The,differences
R6288 T20401 T20404 nsubjpass differences,exploited
R6289 T20402 T20401 amod marked,differences
R629 T3316 T3310 conj undefined,multiple
R6290 T20403 T20401 amod independent,differences
R6291 T20405 T20401 acl demonstrated,differences
R6292 T20406 T20405 prep in,demonstrated
R6293 T20407 T20408 det the,mice
R6294 T20408 T20406 pobj mice,in
R6295 T20409 T20408 nmod B6,mice
R6296 T20410 T20409 cc and,B6
R6297 T20411 T20412 compound A,J
R6298 T20412 T20409 conj J,B6
R6299 T20413 T20412 punct /,J
R630 T3317 T3311 punct ", ",factors
R6300 T20414 T20404 aux can,exploited
R6301 T20415 T20404 auxpass be,exploited
R6302 T20416 T20417 aux to,identify
R6303 T20417 T20404 advcl identify,exploited
R6304 T20418 T20419 amod genetic,determinants
R6305 T20419 T20417 dobj determinants,identify
R6306 T20420 T20419 prep of,determinants
R6307 T20421 T20420 pobj thrombosis,of
R6308 T20422 T20421 cc and,thrombosis
R6309 T20423 T20421 conj haemostasis,thrombosis
R631 T3318 T3311 amod genetic,factors
R6310 T20424 T20404 punct .,exploited
R6311 T20426 T20427 poss Our,results
R6312 T20427 T20428 nsubj results,suggest
R6313 T20429 T20427 prep of,results
R6314 T20430 T20431 det the,screening
R6315 T20431 T20429 pobj screening,of
R6316 T20432 T20431 compound CSS,screening
R6317 T20433 T20434 mark that,used
R6318 T20434 T20428 ccomp used,suggest
R6319 T20435 T20436 amod novel,genes
R632 T3319 T3320 dep that,lead
R6320 T20436 T20434 nsubjpass genes,used
R6321 T20437 T20435 cc or,novel
R6322 T20438 T20435 conj unknown,novel
R6323 T20439 T20434 aux can,used
R6324 T20440 T20434 auxpass be,used
R6325 T20441 T20442 aux to,identify
R6326 T20442 T20434 advcl identify,used
R6327 T20443 T20444 det the,genes
R6328 T20444 T20442 dobj genes,identify
R6329 T20445 T20444 amod responsible,genes
R633 T3320 T3311 relcl lead,factors
R6330 T20446 T20445 prep for,responsible
R6331 T20447 T20448 det the,traits
R6332 T20448 T20446 pobj traits,for
R6333 T20449 T20448 amod related,traits
R6334 T20450 T20449 prep to,related
R6335 T20451 T20452 amod arterial,thrombosis
R6336 T20452 T20450 pobj thrombosis,to
R6337 T20453 T20448 punct ", ",traits
R6338 T20454 T20455 compound tail,rebleeding
R6339 T20455 T20448 appos rebleeding,traits
R634 T3321 T3320 prep to,lead
R6340 T20456 T20455 compound bleeding,rebleeding
R6341 T20457 T20455 punct /,rebleeding
R6342 T20458 T20455 cc and,rebleeding
R6343 T20459 T20460 nmod vessel,matrix
R6344 T20460 T20455 conj matrix,rebleeding
R6345 T20461 T20460 amod extracellular,matrix
R6346 T20462 T20428 punct .,suggest
R6347 T20464 T20465 nsubj Identification,is
R6348 T20466 T20464 prep of,Identification
R6349 T20467 T20466 pobj differences,of
R635 T3322 T3323 amod thrombotic,risk
R6350 T20468 T20467 prep in,differences
R6351 T20469 T20470 det the,strains
R6352 T20470 T20468 pobj strains,in
R6353 T20471 T20470 compound parent,strains
R6354 T20472 T20467 punct ", ",differences
R6355 T20473 T20474 amod such,as
R6356 T20474 T20467 prep as,differences
R6357 T20475 T20474 pobj those,as
R6358 T20476 T20475 acl described,those
R6359 T20477 T20476 prep in,described
R636 T3323 T3321 pobj risk,to
R6360 T20478 T20479 det this,study
R6361 T20479 T20477 pobj study,in
R6362 T20480 T20464 punct ", ",Identification
R6363 T20481 T20464 cc and,Identification
R6364 T20482 T20464 conj screening,Identification
R6365 T20483 T20482 prep of,screening
R6366 T20484 T20485 det the,CSS
R6367 T20485 T20483 pobj CSS,of
R6368 T20486 T20487 det a,step
R6369 T20487 T20465 attr step,is
R637 T3324 T3292 punct .,lagged
R6370 T20488 T20487 amod first,step
R6371 T20489 T20487 punct -,step
R6372 T20490 T20487 prep in,step
R6373 T20491 T20492 det the,discovery
R6374 T20492 T20490 pobj discovery,in
R6375 T20493 T20492 prep of,discovery
R6376 T20494 T20495 amod new,determinants
R6377 T20495 T20493 pobj determinants,of
R6378 T20496 T20495 amod genetic,determinants
R6379 T20497 T20495 prep of,determinants
R638 T3326 T3327 advmod Moreover,remains
R6380 T20498 T20499 amod thrombotic,risk
R6381 T20499 T20497 pobj risk,of
R6382 T20500 T20465 punct .,is
R6383 T20522 T20523 det The,history
R6384 T20523 T20525 nsubjpass history,accessed
R6385 T20524 T20523 amod pre-publication,history
R6386 T20526 T20523 prep for,history
R6387 T20527 T20528 det this,paper
R6388 T20528 T20526 pobj paper,for
R6389 T20529 T20525 aux can,accessed
R639 T3328 T3327 punct ", ",remains
R6390 T20530 T20525 auxpass be,accessed
R6391 T20531 T20525 advmod here,accessed
R6392 T20532 T20525 punct :,accessed
R6393 T20565 T20564 prep of,Identification
R6394 T20566 T20565 pobj mice,of
R6395 T20567 T20566 amod susceptible,mice
R6396 T20568 T20567 cc or,susceptible
R6397 T20569 T20567 conj resistant,susceptible
R6398 T20570 T20569 prep to,resistant
R6399 T20571 T20570 pobj obesity,to
R640 T3329 T3327 nsubj it,remains
R6400 T20572 T20571 punct ", ",obesity
R6401 T20573 T20571 conj atherosclerosis,obesity
R6402 T20574 T20573 punct ", ",atherosclerosis
R6403 T20575 T20573 cc and,atherosclerosis
R6404 T20576 T20577 amod vascular,injury
R6405 T20577 T20573 conj injury,atherosclerosis
R6406 T20771 T20772 amod Arterial,occlusion
R6407 T20772 T20773 compound occlusion,time
R6408 T20774 T20773 prep in,time
R6409 T20775 T20776 nmod B6,mice
R641 T3330 T3327 oprd unclear,remains
R6410 T20776 T20774 pobj mice,in
R6411 T20777 T20775 cc and,B6
R6412 T20778 T20779 compound A,J
R6413 T20779 T20775 conj J,B6
R6414 T20780 T20779 punct /,J
R6415 T20781 T20773 punct .,time
R6416 T20783 T20784 compound Panels,A
R6417 T20784 T20785 nsubj A,are
R6418 T20786 T20784 cc and,A
R6419 T20787 T20784 conj B,A
R642 T3331 T3332 advmod how,influences
R6420 T20788 T20789 amod representative,curves
R6421 T20789 T20785 attr curves,are
R6422 T20790 T20789 compound occlusion,curves
R6423 T20791 T20789 prep from,curves
R6424 T20792 T20793 det each,genotype
R6425 T20793 T20791 pobj genotype,from
R6426 T20794 T20785 punct .,are
R6427 T20796 T20797 amod Red,arrows
R6428 T20797 T20798 nsubj arrows,indicate
R6429 T20799 T20798 dobj duration,indicate
R643 T3332 T3327 ccomp influences,remains
R6430 T20800 T20799 prep of,duration
R6431 T20801 T20802 amod ferric,chloride
R6432 T20802 T20803 compound chloride,application
R6433 T20803 T20800 pobj application,of
R6434 T20804 T20803 prep to,application
R6435 T20805 T20806 det the,carotid
R6436 T20806 T20804 pobj carotid,to
R6437 T20807 T20798 punct .,indicate
R6438 T20809 T20810 compound Panel,A
R6439 T20811 T20810 punct : ,A
R644 T3333 T3334 amod genetic,background
R6440 T20812 T20813 compound B6,mice
R6441 T20813 T20810 appos mice,A
R6442 T20814 T20810 punct ", ",A
R6443 T20815 T20816 compound Panel,B
R6444 T20816 T20810 appos B,A
R6445 T20817 T20816 punct : ,B
R6446 T20818 T20819 compound A,J
R6447 T20819 T20821 compound J,mice
R6448 T20820 T20819 punct /,J
R6449 T20821 T20816 appos mice,B
R645 T3334 T3332 nsubj background,influences
R6450 T20822 T20810 punct .,A
R6451 T20824 T20825 compound Panel,C
R6452 T20826 T20825 punct : ,C
R6453 T20827 T20828 amod Arterial,occlusion
R6454 T20828 T20829 compound occlusion,time
R6455 T20829 T20825 appos time,C
R6456 T20830 T20829 punct ", ",time
R6457 T20831 T20832 nmod mean,SEM
R6458 T20832 T20829 appos SEM,time
R6459 T20833 T20832 punct ±,SEM
R646 T3335 T3336 det the,function
R6460 T20834 T20832 prep of,SEM
R6461 T20835 T20836 compound 14,17
R6462 T20836 T20838 nummod 17,mice
R6463 T20837 T20836 punct –,17
R6464 T20838 T20834 pobj mice,of
R6465 T20839 T20838 prep per,mice
R6466 T20840 T20839 pobj genotype,per
R6467 T20841 T20825 punct .,C
R6468 T20843 T20844 nsubj Symbol,indicates
R6469 T20845 T20846 det a,difference
R647 T3336 T3332 dobj function,influences
R6470 T20846 T20844 dobj difference,indicates
R6471 T20847 T20846 amod significant,difference
R6472 T20848 T20849 punct (,0.01
R6473 T20849 T20846 parataxis 0.01,difference
R6474 T20850 T20851 punct **,P
R6475 T20851 T20849 nsubj P,0.01
R6476 T20852 T20849 punct <,0.01
R6477 T20853 T20849 punct ),0.01
R6478 T20854 T20846 prep between,difference
R6479 T20855 T20856 compound B6,mice
R648 T3337 T3336 prep of,function
R6480 T20856 T20854 pobj mice,between
R6481 T20857 T20846 acl determined,difference
R6482 T20858 T20857 prep with,determined
R6483 T20859 T20860 det a,test
R6484 T20860 T20858 pobj test,with
R6485 T20861 T20860 compound t,test
R6486 T20862 T20860 punct -,test
R6487 T20863 T20844 punct .,indicates
R6488 T21152 T21153 nmod Bleeding,time
R6489 T21154 T21152 cc and,Bleeding
R649 T3338 T3337 pobj molecules,of
R6490 T21155 T21152 conj rebleeding,Bleeding
R6491 T21156 T21153 prep in,time
R6492 T21157 T21158 nmod B6,mice
R6493 T21158 T21156 pobj mice,in
R6494 T21159 T21157 punct ", ",B6
R6495 T21160 T21161 compound A,J
R6496 T21161 T21157 conj J,B6
R6497 T21162 T21161 punct /,J
R6498 T21163 T21161 punct ", ",J
R6499 T21164 T21161 conj Lepob,J
R650 T3339 T3338 cc and,molecules
R6500 T21165 T21164 punct ", ",Lepob
R6501 T21166 T21164 conj Plg,Lepob
R6502 T21167 T21166 punct -,Plg
R6503 T21168 T21166 punct /,Plg
R6504 T21169 T21166 punct -,Plg
R6505 T21170 T21166 cc and,Plg
R6506 T21171 T21166 conj PAI,Plg
R6507 T21172 T21171 punct -,PAI
R6508 T21173 T21171 nummod 1,PAI
R6509 T21174 T21171 punct -,PAI
R651 T3340 T3338 conj pathways,molecules
R6510 T21175 T21171 punct /,PAI
R6511 T21176 T21171 punct -,PAI
R6512 T21177 T21153 punct .,time
R6513 T21179 T21180 nmod Panel,B
R6514 T21180 T21183 dep B,time
R6515 T21181 T21180 nmod A,B
R6516 T21182 T21180 punct ", ",B
R6517 T21184 T21183 punct : ,time
R6518 T21185 T21183 compound Bleeding,time
R6519 T21186 T21187 punct (,seconds
R652 T3341 T3338 acl known,molecules
R6520 T21187 T21183 parataxis seconds,time
R6521 T21188 T21187 punct ),seconds
R6522 T21189 T21183 cc and,time
R6523 T21190 T21191 nmod Panel,D
R6524 T21191 T21194 dep D,time
R6525 T21192 T21191 nmod C,D
R6526 T21193 T21191 punct ", ",D
R6527 T21194 T21183 conj time,time
R6528 T21195 T21194 punct : ,time
R6529 T21196 T21194 compound Rebleeding,time
R653 T3342 T3343 aux to,regulate
R6530 T21197 T21198 punct (,seconds
R6531 T21198 T21194 parataxis seconds,time
R6532 T21199 T21198 punct ),seconds
R6533 T21200 T21194 punct .,time
R6534 T21202 T21203 aux To,determine
R6535 T21203 T21204 advcl determine,compared
R6536 T21205 T21206 amod statistical,differences
R6537 T21206 T21203 dobj differences,determine
R6538 T21207 T21204 punct ", ",compared
R6539 T21208 T21204 nsubjpass values,compared
R654 T3343 T3341 xcomp regulate,known
R6540 T21209 T21208 prep from,values
R6541 T21210 T21209 pobj B6,from
R6542 T21211 T21210 cc and,B6
R6543 T21212 T21213 compound A,J
R6544 T21213 T21210 conj J,B6
R6545 T21214 T21213 punct /,J
R6546 T21215 T21209 cc and,from
R6547 T21216 T21209 conj from,from
R6548 T21217 T21216 pobj WT,from
R6549 T21218 T21217 cc and,WT
R655 T3344 T3345 compound thrombus,formation
R6550 T21219 T21217 conj Plg,WT
R6551 T21220 T21219 punct -,Plg
R6552 T21221 T21219 punct /,Plg
R6553 T21222 T21219 punct -,Plg
R6554 T21223 T21216 pobj littermates,from
R6555 T21224 T21204 auxpass were,compared
R6556 T21225 T21204 prep with,compared
R6557 T21226 T21227 det a,test
R6558 T21227 T21225 pobj test,with
R6559 T21228 T21227 compound t,test
R656 T3345 T3343 dobj formation,regulate
R6560 T21229 T21227 punct -,test
R6561 T21230 T21204 punct ", ",compared
R6562 T21231 T21204 cc and,compared
R6563 T21232 T21233 nsubjpass values,compared
R6564 T21233 T21204 conj compared,compared
R6565 T21234 T21232 prep from,values
R6566 T21235 T21234 pobj B6,from
R6567 T21236 T21235 punct ", ",B6
R6568 T21237 T21235 conj PAI,B6
R6569 T21238 T21237 punct -,PAI
R657 T3346 T3345 cc and,formation
R6570 T21239 T21237 nummod 1,PAI
R6571 T21240 T21237 punct -,PAI
R6572 T21241 T21237 punct /,PAI
R6573 T21242 T21237 punct -,PAI
R6574 T21243 T21237 cc and,PAI
R6575 T21244 T21237 conj Lepob,PAI
R6576 T21245 T21233 auxpass were,compared
R6577 T21246 T21233 prep by,compared
R6578 T21247 T21248 det a,ANOVA
R6579 T21248 T21246 pobj ANOVA,by
R658 T3347 T3345 conj lysis,formation
R6580 T21249 T21250 nummod one,way
R6581 T21250 T21248 compound way,ANOVA
R6582 T21251 T21250 punct -,way
R6583 T21252 T21248 cc and,ANOVA
R6584 T21253 T21254 det a,post-test
R6585 T21254 T21248 conj post-test,ANOVA
R6586 T21255 T21256 compound Newman,Keuls
R6587 T21256 T21254 compound Keuls,post-test
R6588 T21257 T21256 punct -,Keuls
R6589 T21258 T21233 punct .,compared
R659 T3348 T3332 cc and,influences
R6590 T21260 T21261 nsubj Symbols,indicate
R6591 T21262 T21263 det a,difference
R6592 T21263 T21261 dobj difference,indicate
R6593 T21264 T21263 amod significant,difference
R6594 T21265 T21266 punct (,0.001
R6595 T21266 T21263 parataxis 0.001,difference
R6596 T21267 T21268 punct *,P
R6597 T21268 T21269 nsubj P,0.05
R6598 T21269 T21266 ccomp 0.05,0.001
R6599 T21270 T21269 punct <,0.05
R660 T3349 T3332 punct ", ",influences
R6600 T21271 T21266 punct ", ",0.001
R6601 T21272 T21273 punct **,P
R6602 T21273 T21274 nsubj P,0.01
R6603 T21274 T21266 ccomp 0.01,0.001
R6604 T21275 T21274 punct <,0.01
R6605 T21276 T21266 punct ", ",0.001
R6606 T21277 T21278 punct ***,P
R6607 T21278 T21266 nsubj P,0.001
R6608 T21279 T21266 punct <,0.001
R6609 T21280 T21266 punct ),0.001
R661 T3350 T3351 advmod thereby,contributes
R6610 T21281 T21263 prep between,difference
R6611 T21282 T21283 nmod B6,mice
R6612 T21283 T21281 pobj mice,between
R6613 T21284 T21282 cc or,B6
R6614 T21285 T21282 conj WT,B6
R6615 T21286 T21261 punct .,indicate
R6616 T21288 T21289 nsubj Values,are
R6617 T21290 T21291 det the,SEM
R6618 T21291 T21289 attr SEM,are
R6619 T21292 T21291 nmod mean,SEM
R662 T3351 T3332 conj contributes,influences
R6620 T21293 T21291 punct ±,SEM
R6621 T21294 T21291 prep of,SEM
R6622 T21295 T21296 quantmod 10,34
R6623 T21296 T21298 nummod 34,mice
R6624 T21297 T21296 punct –,34
R6625 T21298 T21294 pobj mice,of
R6626 T21299 T21298 prep per,mice
R6627 T21300 T21299 pobj genotype,per
R6628 T21301 T21289 punct .,are
R6629 T21612 T21613 compound Tail,morphology
R663 T3352 T3351 punct ", ",contributes
R6630 T21614 T21613 cc and,morphology
R6631 T21615 T21613 conj collagen,morphology
R6632 T21616 T21615 punct .,collagen
R6633 T21618 T21619 nsubjpass Tails,excised
R6634 T21620 T21619 auxpass were,excised
R6635 T21621 T21619 punct ", ",excised
R6636 T21622 T21619 conj embedded,excised
R6637 T21623 T21622 prep in,embedded
R6638 T21624 T21623 pobj OCT,in
R6639 T21625 T21622 punct ", ",embedded
R664 T3353 T3351 prep to,contributes
R6640 T21626 T21622 conj sectioned,embedded
R6641 T21627 T21626 punct ", ",sectioned
R6642 T21628 T21626 cc and,sectioned
R6643 T21629 T21626 conj stained,sectioned
R6644 T21630 T21629 prep with,stained
R6645 T21631 T21632 compound Hematoxylin,Eosin
R6646 T21632 T21630 pobj Eosin,with
R6647 T21633 T21632 punct /,Eosin
R6648 T21634 T21632 cc or,Eosin
R6649 T21635 T21636 poss Masson,Trichrome
R665 T3354 T3355 det the,risk
R6650 T21636 T21632 conj Trichrome,Eosin
R6651 T21637 T21635 case 's,Masson
R6652 T21638 T21619 punct .,excised
R6653 T21640 T21641 compound Panel,A
R6654 T21642 T21641 punct : ,A
R6655 T21643 T21644 amod Representative,sections
R6656 T21644 T21641 appos sections,A
R6657 T21645 T21644 acl stained,sections
R6658 T21646 T21645 prep with,stained
R6659 T21647 T21646 pobj hematoxylin,with
R666 T3355 T3353 pobj risk,to
R6660 T21648 T21647 cc and,hematoxylin
R6661 T21649 T21647 conj eosin,hematoxylin
R6662 T21650 T21644 prep from,sections
R6663 T21651 T21652 nmod B6,mice
R6664 T21652 T21650 pobj mice,from
R6665 T21653 T21651 cc and,B6
R6666 T21654 T21655 compound A,J
R6667 T21655 T21651 conj J,B6
R6668 T21656 T21655 punct /,J
R6669 T21657 T21641 punct .,A
R667 T3356 T3355 prep of,risk
R6670 T21659 T21660 compound Panel,B
R6671 T21661 T21660 punct : ,B
R6672 T21662 T21663 amod Representative,sections
R6673 T21663 T21660 appos sections,B
R6674 T21664 T21663 acl stained,sections
R6675 T21665 T21664 prep with,stained
R6676 T21666 T21667 poss Masson,Trichrome
R6677 T21667 T21665 pobj Trichrome,with
R6678 T21668 T21666 case 's,Masson
R6679 T21669 T21663 prep from,sections
R668 T3357 T3358 amod thrombotic,disease
R6680 T21670 T21671 nmod B6,mice
R6681 T21671 T21669 pobj mice,from
R6682 T21672 T21670 cc and,B6
R6683 T21673 T21674 compound A,J
R6684 T21674 T21670 conj J,B6
R6685 T21675 T21674 punct /,J
R6686 T21676 T21660 punct .,B
R6687 T21678 T21679 det The,color
R6688 T21679 T21681 nsubj color,identifies
R6689 T21680 T21679 amod blue,color
R669 T3358 T3356 pobj disease,of
R6690 T21682 T21683 det the,collagen
R6691 T21683 T21681 dobj collagen,identifies
R6692 T21684 T21681 punct .,identifies
R6693 T21686 T21687 compound Panel,C
R6694 T21687 T21688 dep C,determined
R6695 T21689 T21688 punct : ,determined
R6696 T21690 T21691 det The,percentage
R6697 T21691 T21688 nsubjpass percentage,determined
R6698 T21692 T21691 prep of,percentage
R6699 T21693 T21694 det the,area
R670 T3359 T3327 punct .,remains
R6700 T21694 T21692 pobj area,of
R6701 T21695 T21694 compound collagen,area
R6702 T21696 T21694 punct (,area
R6703 T21697 T21694 acl excluding,area
R6704 T21698 T21699 compound center,bone
R6705 T21699 T21697 dobj bone,excluding
R6706 T21700 T21699 punct /,bone
R6707 T21701 T21699 appos cartilage,bone
R6708 T21702 T21691 punct ),percentage
R6709 T21703 T21691 prep of,percentage
R671 T3465 T3462 punct ;,10
R6710 T21704 T21705 det the,area
R6711 T21705 T21703 pobj area,of
R6712 T21706 T21705 amod total,area
R6713 T21707 T21705 compound tail,area
R6714 T21708 T21705 prep of,area
R6715 T21709 T21710 det each,section
R6716 T21710 T21708 pobj section,of
R6717 T21711 T21688 auxpass was,determined
R6718 T21712 T21688 prep in,determined
R6719 T21713 T21714 quantmod 3,4
R672 T3466 T3467 compound A,J
R6720 T21714 T21716 nummod 4,sections
R6721 T21715 T21714 punct –,4
R6722 T21716 T21712 pobj sections,in
R6723 T21717 T21688 prep at,determined
R6724 T21718 T21719 quantmod 2,3
R6725 T21719 T21721 nummod 3,sites
R6726 T21720 T21719 punct –,3
R6727 T21721 T21717 pobj sites,at
R6728 T21722 T21721 prep for,sites
R6729 T21723 T21724 det each,tail
R673 T3467 T3469 nsubj J,susceptible
R6730 T21724 T21722 pobj tail,for
R6731 T21725 T21688 cc and,determined
R6732 T21726 T21688 conj averaged,determined
R6733 T21727 T21726 prep for,averaged
R6734 T21728 T21729 det each,mouse
R6735 T21729 T21727 pobj mouse,for
R6736 T21730 T21688 punct .,determined
R6737 T21732 T21733 nsubj Values,are
R6738 T21734 T21735 det the,SEM
R6739 T21735 T21733 attr SEM,are
R674 T3468 T3467 punct /,J
R6740 T21736 T21735 nmod mean,SEM
R6741 T21737 T21735 punct ±,SEM
R6742 T21738 T21735 prep of,SEM
R6743 T21739 T21740 quantmod 4,8
R6744 T21740 T21742 nummod 8,mice
R6745 T21741 T21740 punct –,8
R6746 T21742 T21738 pobj mice,of
R6747 T21743 T21742 prep per,mice
R6748 T21744 T21743 pobj genotype,per
R6749 T21745 T21733 punct .,are
R675 T3469 T3462 amod susceptible,10
R6750 T21747 T21748 nsubj Symbol,indicates
R6751 T21749 T21750 det a,difference
R6752 T21750 T21748 dobj difference,indicates
R6753 T21751 T21750 amod significant,difference
R6754 T21752 T21753 punct (,0.05
R6755 T21753 T21750 parataxis 0.05,difference
R6756 T21754 T21755 punct *,P
R6757 T21755 T21753 nsubj P,0.05
R6758 T21756 T21753 punct <,0.05
R6759 T21757 T21753 punct ),0.05
R676 T3470 T3462 punct ),10
R6760 T21758 T21750 prep between,difference
R6761 T21759 T21760 compound B6,mice
R6762 T21760 T21758 pobj mice,between
R6763 T21761 T21750 acl determined,difference
R6764 T21762 T21761 agent by,determined
R6765 T21763 T21764 compound t,test
R6766 T21764 T21762 pobj test,by
R6767 T21765 T21764 punct -,test
R6768 T21766 T21748 punct .,indicates
R6769 T21929 T21930 nmod Bleeding,time
R677 T3471 T3462 punct [,10
R6770 T21931 T21929 cc and,Bleeding
R6771 T21932 T21929 conj rebleeding,Bleeding
R6772 T21933 T21930 prep in,time
R6773 T21934 T21935 det the,CSS
R6774 T21935 T21933 pobj CSS,in
R6775 T21936 T21930 punct .,time
R6776 T21938 T21939 compound Panel,A
R6777 T21940 T21939 punct : ,A
R6778 T21941 T21942 compound Bleeding,Time
R6779 T21942 T21939 appos Time,A
R678 T3472 T3462 punct ],10
R6780 T21943 T21944 punct (,seconds
R6781 T21944 T21942 parataxis seconds,Time
R6782 T21945 T21944 punct ),seconds
R6783 T21946 T21939 punct .,A
R6784 T21948 T21949 compound Panel,B
R6785 T21950 T21949 punct : ,B
R6786 T21951 T21952 compound Rebleeding,Time
R6787 T21952 T21949 appos Time,B
R6788 T21953 T21954 punct (,seconds
R6789 T21954 T21952 parataxis seconds,Time
R679 T3473 T3402 punct .,have
R6790 T21955 T21954 punct ),seconds
R6791 T21956 T21949 punct .,B
R6792 T21958 T21959 nsubj Bars,are
R6793 T21960 T21961 det the,SEM
R6794 T21961 T21959 attr SEM,are
R6795 T21962 T21961 nmod mean,SEM
R6796 T21963 T21961 punct ±,SEM
R6797 T21964 T21961 prep of,SEM
R6798 T21965 T21966 quantmod 7,28
R6799 T21966 T21968 nummod 28,mice
R680 T3475 T3476 det These,conditions
R6800 T21967 T21966 punct –,28
R6801 T21968 T21964 pobj mice,of
R6802 T21969 T21959 punct .,are
R6803 T21971 T21972 amod Statistical,differences
R6804 T21972 T21973 nsubjpass differences,determined
R6805 T21974 T21972 prep between,differences
R6806 T21975 T21976 compound B6,mice
R6807 T21976 T21974 pobj mice,between
R6808 T21977 T21976 cc and,mice
R6809 T21978 T21976 conj CSS,mice
R681 T3476 T3477 nsubj conditions,are
R6810 T21979 T21973 auxpass were,determined
R6811 T21980 T21973 prep with,determined
R6812 T21981 T21982 det a,test
R6813 T21982 T21980 pobj test,with
R6814 T21983 T21982 compound t,test
R6815 T21984 T21982 punct -,test
R6816 T21985 T21973 punct ", ",determined
R6817 T21986 T21973 cc and,determined
R6818 T21987 T21988 det a,correction
R6819 T21988 T21990 nsubjpass correction,made
R682 T3478 T3477 acomp predisposing,are
R6820 T21989 T21988 compound Bonferroni,correction
R6821 T21990 T21973 conj made,determined
R6822 T21991 T21990 auxpass was,made
R6823 T21992 T21993 aux to,determine
R6824 T21993 T21990 advcl determine,made
R6825 T21994 T21995 compound significance,value
R6826 T21995 T21993 dobj value,determine
R6827 T21996 T21997 punct (,0.002
R6828 T21997 T21995 parataxis 0.002,value
R6829 T21998 T21997 nsubj P,0.002
R683 T3479 T3478 prep to,predisposing
R6830 T21999 T21997 punct <,0.002
R6831 T22000 T21997 punct ),0.002
R6832 T22001 T21990 punct .,made
R6833 T22003 T22004 nsubj Symbols,indicate
R6834 T22005 T22006 det a,difference
R6835 T22006 T22004 dobj difference,indicate
R6836 T22007 T22006 amod significant,difference
R6837 T22008 T22006 prep between,difference
R6838 T22009 T22010 compound B6,values
R6839 T22010 T22008 pobj values,between
R684 T3480 T3479 pobj thrombosis,to
R6840 T22011 T22004 punct .,indicate
R6841 T22013 T22014 punct *,P
R6842 T22014 T22015 nsubj P,0.002
R6843 T22016 T22015 punct <,0.002
R6844 T22017 T22015 punct .,0.002
R6845 T22254 T22255 nmod Bleeding,time
R6846 T22256 T22254 cc and,Bleeding
R6847 T22257 T22254 conj rebleeding,Bleeding
R6848 T22258 T22255 prep in,time
R6849 T22259 T22260 det the,backcrosses
R685 T3481 T3482 advmod per,se
R6850 T22260 T22258 pobj backcrosses,in
R6851 T22261 T22260 compound CSS,backcrosses
R6852 T22262 T22255 punct .,time
R6853 T22264 T22265 compound Panel,A
R6854 T22265 T22266 nsubjpass A,tested
R6855 T22267 T22265 punct : ,A
R6856 T22268 T22269 compound Bleeding,Time
R6857 T22269 T22265 appos Time,A
R6858 T22270 T22271 punct (,seconds
R6859 T22271 T22269 parataxis seconds,Time
R686 T3361 T3362 nsubjpass Many,classified
R6860 T22272 T22271 punct ),seconds
R6861 T22273 T22265 cc and,A
R6862 T22274 T22275 compound Panel,B
R6863 T22275 T22265 conj B,A
R6864 T22276 T22275 punct : ,B
R6865 T22277 T22278 compound Rebleeding,Time
R6866 T22278 T22275 appos Time,B
R6867 T22279 T22280 punct (,seconds
R6868 T22280 T22278 parataxis seconds,Time
R6869 T22281 T22280 punct ),seconds
R687 T3482 T3477 advmod se,are
R6870 T22282 T22266 auxpass were,tested
R6871 T22283 T22266 prep in,tested
R6872 T22284 T22285 amod heterosomic,mice
R6873 T22285 T22283 pobj mice,in
R6874 T22286 T22285 punct ", ",mice
R6875 T22287 T22288 punct (,F1
R6876 T22288 T22285 appos F1,mice
R6877 T22289 T22288 nmod B6xCSS,F1
R6878 T22290 T22289 punct -,B6xCSS
R6879 T22291 T22289 nummod 5,B6xCSS
R688 T3483 T3477 punct ", ",are
R6880 T22292 T22288 punct ),F1
R6881 T22293 T22288 punct (,F1
R6882 T22294 T22288 appos 5F1,F1
R6883 T22295 T22288 punct ),F1
R6884 T22296 T22288 cc and,F1
R6885 T22297 T22298 punct (,F1
R6886 T22298 T22288 conj F1,F1
R6887 T22299 T22298 nmod B6xCSS,F1
R6888 T22300 T22299 punct -,B6xCSS
R6889 T22301 T22299 nummod 17,B6xCSS
R689 T3363 T3361 prep of,Many
R6890 T22302 T22298 punct ),F1
R6891 T22303 T22298 punct (,F1
R6892 T22304 T22298 appos 17F1,F1
R6893 T22305 T22285 punct ),mice
R6894 T22306 T22285 cc and,mice
R6895 T22307 T22308 advmod doubly,heterosomic
R6896 T22308 T22309 amod heterosomic,mice
R6897 T22309 T22285 conj mice,mice
R6898 T22310 T22309 prep for,mice
R6899 T22311 T22312 nmod chromosomes,5
R690 T3484 T3477 cc but,are
R6900 T22312 T22310 pobj 5,for
R6901 T22313 T22312 cc and,5
R6902 T22314 T22312 conj 17,5
R6903 T22315 T22309 punct (,mice
R6904 T22316 T22317 nummod 5,17
R6905 T22317 T22309 appos 17,mice
R6906 T22318 T22317 punct ×,17
R6907 T22319 T22266 punct ),tested
R6908 T22320 T22266 punct .,tested
R6909 T22322 T22323 nsubj Bars,are
R691 T3364 T3365 det the,strains
R6910 T22324 T22325 det the,SEM
R6911 T22325 T22323 attr SEM,are
R6912 T22326 T22325 nmod mean,SEM
R6913 T22327 T22325 punct ±,SEM
R6914 T22328 T22325 prep of,SEM
R6915 T22329 T22330 quantmod 5,8
R6916 T22330 T22333 nummod 8,mice
R6917 T22331 T22330 punct –,8
R6918 T22332 T22330 compound 2,8
R6919 T22333 T22328 pobj mice,of
R692 T3365 T3363 pobj strains,of
R6920 T22334 T22323 punct .,are
R6921 T22336 T22337 amod Statistical,differences
R6922 T22337 T22338 nsubjpass differences,determined
R6923 T22339 T22337 prep between,differences
R6924 T22340 T22341 compound B6,mice
R6925 T22341 T22339 pobj mice,between
R6926 T22342 T22341 cc and,mice
R6927 T22343 T22344 det the,CSS
R6928 T22344 T22341 conj CSS,mice
R6929 T22345 T22338 auxpass were,determined
R693 T3366 T3365 amod available,strains
R6930 T22346 T22338 prep with,determined
R6931 T22347 T22348 det a,test
R6932 T22348 T22346 pobj test,with
R6933 T22349 T22348 compound t,test
R6934 T22350 T22348 punct -,test
R6935 T22351 T22338 punct ", ",determined
R6936 T22352 T22338 cc and,determined
R6937 T22353 T22354 det a,correction
R6938 T22354 T22356 nsubjpass correction,made
R6939 T22355 T22354 compound Bonferroni,correction
R694 T3485 T3486 det these,mice
R6940 T22356 T22338 conj made,determined
R6941 T22357 T22356 auxpass was,made
R6942 T22358 T22359 aux to,determine
R6943 T22359 T22356 advcl determine,made
R6944 T22360 T22361 compound significance,value
R6945 T22361 T22359 dobj value,determine
R6946 T22362 T22363 punct (,0.01
R6947 T22363 T22361 parataxis 0.01,value
R6948 T22364 T22363 nsubj P,0.01
R6949 T22365 T22363 punct <,0.01
R695 T3367 T3368 amod inbred,mouse
R6950 T22366 T22363 punct ),0.01
R6951 T22367 T22356 punct .,made
R6952 T22369 T22370 nsubj Symbols,indicate
R6953 T22371 T22372 det a,difference
R6954 T22372 T22370 dobj difference,indicate
R6955 T22373 T22372 amod significant,difference
R6956 T22374 T22372 prep between,difference
R6957 T22375 T22376 compound B6,values
R6958 T22376 T22374 pobj values,between
R6959 T22377 T22370 punct .,indicate
R696 T3368 T3365 compound mouse,strains
R6960 T22379 T22380 punct *,0.01
R6961 T22381 T22380 nsubj P,0.01
R6962 T22382 T22380 punct <,0.01
R6963 T22383 T22380 punct .,0.01
R6964 T22648 T22647 punct -,PAI
R6965 T22649 T22647 nummod 1,PAI
R6966 T22650 T22647 prep in,PAI
R6967 T22651 T22652 det the,backcrosses
R6968 T22652 T22650 pobj backcrosses,in
R6969 T22653 T22652 compound CSS,backcrosses
R697 T3486 T3487 nsubjpass mice,evaluated
R6970 T22654 T22647 punct .,PAI
R6971 T22656 T22657 compound Panel,A
R6972 T22657 T22658 nsubjpass A,tested
R6973 T22659 T22657 punct : ,A
R6974 T22660 T22661 nmod Plasma,antigen
R6975 T22661 T22657 appos antigen,A
R6976 T22662 T22661 nmod PAI,antigen
R6977 T22663 T22662 punct -,PAI
R6978 T22664 T22662 nummod 1,PAI
R6979 T22665 T22666 punct (,ng
R698 T3369 T3365 punct ", ",strains
R6980 T22666 T22661 parataxis ng,antigen
R6981 T22667 T22668 punct /,mL
R6982 T22668 T22666 prep mL,ng
R6983 T22669 T22666 punct ),ng
R6984 T22670 T22657 cc and,A
R6985 T22671 T22672 compound Panel,B
R6986 T22672 T22657 conj B,A
R6987 T22673 T22672 punct : ,B
R6988 T22674 T22675 nmod Plasma,activity
R6989 T22675 T22672 appos activity,B
R699 T3370 T3371 amod such,as
R6990 T22676 T22675 nmod PAI,activity
R6991 T22677 T22676 punct -,PAI
R6992 T22678 T22676 nummod 1,PAI
R6993 T22679 T22680 punct (,U
R6994 T22680 T22675 parataxis U,activity
R6995 T22681 T22682 punct /,mL
R6996 T22682 T22680 prep mL,U
R6997 T22683 T22680 punct ),U
R6998 T22684 T22658 auxpass were,tested
R6999 T22685 T22658 prep in,tested
R700 T3371 T3365 prep as,strains
R7000 T22686 T22687 amod heterosomic,mice
R7001 T22687 T22685 pobj mice,in
R7002 T22688 T22687 punct ", ",mice
R7003 T22689 T22690 punct (,F1
R7004 T22690 T22687 appos F1,mice
R7005 T22691 T22690 nmod B6xCSS,F1
R7006 T22692 T22691 punct -,B6xCSS
R7007 T22693 T22691 nummod 5,B6xCSS
R7008 T22694 T22690 punct ),F1
R7009 T22695 T22690 punct (,F1
R701 T3487 T3477 conj evaluated,are
R7010 T22696 T22690 appos 5F1,F1
R7011 T22697 T22690 punct ),F1
R7012 T22698 T22690 cc and,F1
R7013 T22699 T22700 punct (,F1
R7014 T22700 T22690 conj F1,F1
R7015 T22701 T22700 nmod B6xCSS,F1
R7016 T22702 T22701 punct -,B6xCSS
R7017 T22703 T22701 nummod 17,B6xCSS
R7018 T22704 T22700 punct ),F1
R7019 T22705 T22700 punct (,F1
R702 T3372 T3373 compound C57BL,6J
R7020 T22706 T22700 appos 17F1,F1
R7021 T22707 T22687 punct ),mice
R7022 T22708 T22687 cc and,mice
R7023 T22709 T22710 advmod doubly,heterosomic
R7024 T22710 T22711 amod heterosomic,mice
R7025 T22711 T22687 conj mice,mice
R7026 T22712 T22711 prep for,mice
R7027 T22713 T22714 nmod chromosomes,5
R7028 T22714 T22712 pobj 5,for
R7029 T22715 T22714 cc and,5
R703 T3373 T3371 pobj 6J,as
R7030 T22716 T22714 conj 17,5
R7031 T22717 T22711 punct (,mice
R7032 T22718 T22719 nummod 5,17
R7033 T22719 T22711 appos 17,mice
R7034 T22720 T22719 punct ×,17
R7035 T22721 T22658 punct ),tested
R7036 T22722 T22658 punct .,tested
R7037 T22724 T22725 nsubj Bars,are
R7038 T22726 T22727 det the,SEM
R7039 T22727 T22725 attr SEM,are
R704 T3374 T3373 punct /,6J
R7040 T22728 T22727 nmod mean,SEM
R7041 T22729 T22727 punct ±,SEM
R7042 T22730 T22727 prep of,SEM
R7043 T22731 T22732 quantmod 5,18
R7044 T22732 T22734 nummod 18,mice
R7045 T22733 T22732 punct –,18
R7046 T22734 T22730 pobj mice,of
R7047 T22735 T22725 punct .,are
R7048 T22737 T22738 amod Statistical,differences
R7049 T22738 T22739 nsubjpass differences,determined
R705 T3488 T3487 aux have,evaluated
R7050 T22740 T22738 prep between,differences
R7051 T22741 T22742 compound B6,mice
R7052 T22742 T22740 pobj mice,between
R7053 T22743 T22742 cc and,mice
R7054 T22744 T22742 conj CSS,mice
R7055 T22745 T22739 auxpass were,determined
R7056 T22746 T22739 prep with,determined
R7057 T22747 T22748 det a,test
R7058 T22748 T22746 pobj test,with
R7059 T22749 T22748 compound t,test
R706 T3375 T3373 punct (,6J
R7060 T22750 T22748 punct -,test
R7061 T22751 T22739 punct ", ",determined
R7062 T22752 T22739 cc and,determined
R7063 T22753 T22754 det a,correction
R7064 T22754 T22756 nsubjpass correction,made
R7065 T22755 T22754 compound Bonferroni,correction
R7066 T22756 T22739 conj made,determined
R7067 T22757 T22756 auxpass was,made
R7068 T22758 T22759 aux to,determine
R7069 T22759 T22756 advcl determine,made
R707 T3376 T3373 appos B6,6J
R7070 T22760 T22761 compound significance,value
R7071 T22761 T22759 dobj value,determine
R7072 T22762 T22763 punct (,0.01
R7073 T22763 T22759 parataxis 0.01,determine
R7074 T22764 T22763 nsubj P,0.01
R7075 T22765 T22763 punct <,0.01
R7076 T22766 T22763 punct ),0.01
R7077 T22767 T22756 punct .,made
R7078 T22769 T22770 nsubj Symbols,indicate
R7079 T22771 T22772 det a,difference
R708 T3377 T3373 punct ),6J
R7080 T22772 T22770 dobj difference,indicate
R7081 T22773 T22772 amod significant,difference
R7082 T22774 T22772 prep between,difference
R7083 T22775 T22776 compound B6,values
R7084 T22776 T22774 pobj values,between
R7085 T22777 T22770 punct .,indicate
R7086 T22779 T22780 punct *,P
R7087 T22780 T22781 nsubj P,0.01
R7088 T22782 T22781 punct <,0.01
R7089 T22783 T22781 punct .,0.01
R709 T3489 T3487 neg not,evaluated
R7090 T22995 T22996 amod Arterial,occlusion
R7091 T22996 T22997 compound occlusion,time
R7092 T22998 T22997 prep in,time
R7093 T22999 T23000 det the,backcrosses
R7094 T23000 T22998 pobj backcrosses,in
R7095 T23001 T23000 compound CSS,backcrosses
R7096 T23002 T22997 punct .,time
R7097 T23004 T23005 compound Occlusion,time
R7098 T23005 T23006 nsubjpass time,determined
R7099 T23007 T23006 auxpass was,determined
R710 T3378 T3373 cc and,6J
R7100 T23008 T23006 prep in,determined
R7101 T23009 T23010 amod heterosomic,mice
R7102 T23010 T23008 pobj mice,in
R7103 T23011 T23010 punct ", ",mice
R7104 T23012 T23010 punct (,mice
R7105 T23013 T23014 nmod B6xCSS,F1
R7106 T23014 T23010 appos F1,mice
R7107 T23015 T23013 punct -,B6xCSS
R7108 T23016 T23013 nummod 5,B6xCSS
R7109 T23017 T23014 punct ),F1
R711 T3379 T3380 compound A,J
R7110 T23018 T23014 punct (,F1
R7111 T23019 T23014 appos 5F1,F1
R7112 T23020 T23014 punct ),F1
R7113 T23021 T23014 cc and,F1
R7114 T23022 T23023 punct (,F1
R7115 T23023 T23014 conj F1,F1
R7116 T23024 T23023 nmod B6xCSS,F1
R7117 T23025 T23024 punct -,B6xCSS
R7118 T23026 T23024 nummod 17,B6xCSS
R7119 T23027 T23023 punct ),F1
R712 T3380 T3373 conj J,6J
R7120 T23028 T23023 punct (,F1
R7121 T23029 T23023 appos 17F1,F1
R7122 T23030 T23010 punct ),mice
R7123 T23031 T23010 punct ", ",mice
R7124 T23032 T23010 cc and,mice
R7125 T23033 T23034 advmod doubly,heterosomic
R7126 T23034 T23035 amod heterosomic,mice
R7127 T23035 T23010 conj mice,mice
R7128 T23036 T23035 prep for,mice
R7129 T23037 T23038 nmod chromosomes,5
R713 T3490 T3487 auxpass been,evaluated
R7130 T23038 T23036 pobj 5,for
R7131 T23039 T23038 cc and,5
R7132 T23040 T23038 conj 17,5
R7133 T23041 T23035 punct (,mice
R7134 T23042 T23043 nummod 5,17
R7135 T23043 T23035 appos 17,mice
R7136 T23044 T23043 punct ×,17
R7137 T23045 T23006 punct ),determined
R7138 T23046 T23006 punct .,determined
R7139 T23048 T23049 nsubj Bars,are
R714 T3381 T3380 punct /,J
R7140 T23050 T23051 det the,SEM
R7141 T23051 T23049 attr SEM,are
R7142 T23052 T23051 nmod mean,SEM
R7143 T23053 T23051 punct ±,SEM
R7144 T23054 T23051 prep of,SEM
R7145 T23055 T23056 quantmod 5,18
R7146 T23056 T23058 nummod 18,mice
R7147 T23057 T23056 punct –,18
R7148 T23058 T23054 pobj mice,of
R7149 T23059 T23049 punct .,are
R715 T3382 T3362 punct ", ",classified
R7150 T23061 T23062 amod Statistical,differences
R7151 T23062 T23063 nsubjpass differences,determined
R7152 T23064 T23062 prep between,differences
R7153 T23065 T23066 compound B6,mice
R7154 T23066 T23064 pobj mice,between
R7155 T23067 T23066 cc and,mice
R7156 T23068 T23066 conj CSS,mice
R7157 T23069 T23063 auxpass were,determined
R7158 T23070 T23063 prep with,determined
R7159 T23071 T23072 det a,test
R716 T3383 T3362 aux have,classified
R7160 T23072 T23070 pobj test,with
R7161 T23073 T23072 compound t,test
R7162 T23074 T23072 punct -,test
R7163 T23075 T23063 punct ", ",determined
R7164 T23076 T23063 cc and,determined
R7165 T23077 T23078 det a,correction
R7166 T23078 T23080 nsubjpass correction,made
R7167 T23079 T23078 compound Bonferroni,correction
R7168 T23080 T23063 conj made,determined
R7169 T23081 T23080 auxpass was,made
R717 T3384 T3362 auxpass been,classified
R7170 T23082 T23083 aux to,determine
R7171 T23083 T23080 advcl determine,made
R7172 T23084 T23085 compound significance,value
R7173 T23085 T23083 dobj value,determine
R7174 T23086 T23087 punct (,0.02
R7175 T23087 T23085 parataxis 0.02,value
R7176 T23088 T23087 nsubj P,0.02
R7177 T23089 T23087 punct <,0.02
R7178 T23090 T23087 punct ),0.02
R7179 T23091 T23080 punct .,made
R718 T3385 T3362 prep as,classified
R7180 T23093 T23094 nsubj Symbols,indicate
R7181 T23095 T23096 det a,difference
R7182 T23096 T23094 dobj difference,indicate
R7183 T23097 T23096 amod significant,difference
R7184 T23098 T23096 prep between,difference
R7185 T23099 T23100 compound B6,values
R7186 T23100 T23098 pobj values,between
R7187 T23101 T23094 punct .,indicate
R7188 T23103 T23104 punct *,P
R7189 T23104 T23105 nsubj P,0.0001
R719 T3386 T3385 amod resistant,as
R7190 T23106 T23105 punct <,0.0001
R7191 T23107 T23105 punct .,0.0001
R7192 T23141 T23142 nmod Coagulation,Parameters
R7193 T23143 T23141 cc and,Coagulation
R7194 T23144 T23141 conj Plasminogen,Coagulation
R7195 T23145 T23142 compound System,Parameters
R7196 T23146 T23142 prep in,Parameters
R7197 T23147 T23148 nmod B6,strains
R7198 T23148 T23146 pobj strains,in
R7199 T23149 T23147 cc and,B6
R720 T3491 T3487 advmod systematically,evaluated
R7200 T23150 T23151 compound A,J
R7201 T23151 T23147 conj J,B6
R7202 T23152 T23151 punct /,J
R7203 T23153 T23148 amod inbred,strains
R7204 T23154 T23148 compound mouse,strains
R721 T3387 T3386 cc or,resistant
R722 T3388 T3386 conj susceptible,resistant
R723 T3389 T3388 prep to,susceptible
R724 T3492 T3487 prep for,evaluated
R725 T3390 T3391 amod particular,diseases
R726 T3391 T3389 pobj diseases,to
R727 T3493 T3492 pobj thrombosis,for
R728 T3392 T3391 amod complex,diseases
R729 T3393 T3394 punct (,Table
R730 T3394 T3362 parataxis Table,classified
R731 T3494 T3487 punct .,evaluated
R732 T3395 T3394 nummod 1,Table
R733 T3396 T3394 punct ),Table
R734 T3397 T3362 punct .,classified
R735 T3496 T3497 compound Clot,formation
R736 T3399 T3400 det These,strains
R737 T3400 T3402 nsubj strains,have
R738 T3401 T3400 nummod two,strains
R739 T3497 T3498 nsubj formation,requires
R740 T3403 T3404 amod diverse,responses
R741 T3404 T3402 dobj responses,have
R742 T3405 T3404 prep to,responses
R743 T3499 T3497 cc and,formation
R744 T3406 T3407 npadvmod diet,induced
R745 T3407 T3409 amod induced,obesity
R746 T3408 T3407 punct -,induced
R747 T3409 T3405 pobj obesity,to
R748 T3500 T3497 conj lysis,formation
R749 T3410 T3411 punct [,8
R750 T3411 T3409 parataxis 8,obesity
R751 T3412 T3411 punct ],8
R752 T3501 T3497 punct ", ",formation
R753 T3413 T3414 punct (,resistant
R754 T3414 T3409 parataxis resistant,obesity
R755 T3415 T3416 nsubj B6,susceptible
R756 T3502 T3503 dep which,determine
R757 T3416 T3414 amod susceptible,resistant
R758 T3417 T3414 punct ;,resistant
R759 T3418 T3419 compound A,J
R760 T3503 T3497 relcl determine,formation
R761 T3419 T3414 nsubj J,resistant
R762 T3420 T3419 punct /,J
R763 T3421 T3414 punct ),resistant
R764 T3504 T3503 advmod ultimately,determine
R765 T3422 T3409 punct ", ",obesity
R766 T3423 T3424 npadvmod diet,induced
R767 T3424 T3426 amod induced,atherosclerosis
R768 T3425 T3424 punct -,induced
R769 T3505 T3503 dobj thrombosis,determine
R770 T3506 T3498 punct ", ",requires
R771 T3426 T3409 conj atherosclerosis,obesity
R772 T3427 T3428 punct (,resistant
R773 T3507 T3508 compound platelet,aggregation
R774 T3428 T3426 parataxis resistant,atherosclerosis
R775 T3429 T3430 nsubj B6,susceptible
R776 T3508 T3498 dobj aggregation,requires
R777 T3430 T3428 amod susceptible,resistant
R778 T3431 T3428 punct ;,resistant
R779 T3432 T3433 compound A,J
R780 T3509 T3508 punct ", ",aggregation
R781 T3433 T3428 nsubj J,resistant
R782 T3434 T3433 punct /,J
R783 T3510 T3508 conj coagulation,aggregation
R784 T3435 T3428 punct ),resistant
R785 T3436 T3437 punct [,9
R786 T3511 T3510 punct ", ",coagulation
R787 T3437 T3426 parataxis 9,atherosclerosis
R788 T3438 T3437 punct ],9
R789 T3439 T3426 punct ", ",atherosclerosis
R790 T3512 T3510 cc and,coagulation
R791 T3440 T3441 amod arterial,ligation
R792 T3441 T3442 npadvmod ligation,induced
R793 T3442 T3444 amod induced,hyperplasia
R794 T3443 T3442 punct -,induced
R795 T3513 T3514 amod fibrinolytic,functions
R796 T3444 T3426 conj hyperplasia,atherosclerosis
R797 T3445 T3444 amod neointimal,hyperplasia
R798 T3514 T3510 conj functions,coagulation
R799 T3446 T3447 punct (,resistant
R800 T3447 T3444 parataxis resistant,hyperplasia
R801 T3448 T3449 nsubj B6,resistant
R802 T3515 T3498 punct .,requires
R803 T3449 T3447 amod resistant,resistant
R804 T3450 T3447 punct ;,resistant
R805 T3517 T3518 nsubj Interactions,occur
R806 T3451 T3452 compound A,J
R807 T3452 T3447 nsubj J,resistant
R808 T3453 T3452 punct /,J
R809 T3454 T3447 punct ),resistant
R810 T3455 T3444 punct ", ",hyperplasia
R811 T3519 T3517 prep among,Interactions
R812 T3456 T3444 cc and,hyperplasia
R813 T3457 T3458 npadvmod ligation,induced
R814 T3458 T3459 amod induced,remodeling
R815 T3459 T3444 conj remodeling,hyperplasia
R816 T3520 T3521 det these,pathways
R817 T3460 T3459 compound vessel,remodeling
R818 T3461 T3462 punct (,10
R819 T3521 T3519 pobj pathways,among
R820 T3462 T3459 parataxis 10,remodeling
R821 T3463 T3464 nsubj B6,resistant
R822 T3464 T3462 amod resistant,10
R823 T3522 T3518 aux may,occur
R824 T3523 T3518 cc and,occur
R825 T3524 T3525 amod additional,factors
R826 T3571 T3572 nsubjpass panel,generated
R827 T3525 T3526 nsubj factors,modulate
R828 T3573 T3571 prep of,panel
R829 T3574 T3575 compound chromosome,strains
R830 T3526 T3518 conj modulate,occur
R831 T3575 T3573 pobj strains,of
R832 T3576 T3575 compound substitution,strains
R833 T3527 T3526 aux may,modulate
R834 T3577 T3575 punct (,strains
R835 T3578 T3575 appos CSS,strains
R836 T3528 T3529 det these,processes
R837 T3579 T3572 punct ),generated
R838 T3580 T3572 auxpass was,generated
R839 T3581 T3582 punct [,11
R840 T3529 T3526 dobj processes,modulate
R841 T3582 T3572 parataxis 11,generated
R842 T3583 T3582 punct ],11
R843 T3584 T3572 agent by,generated
R844 T3530 T3526 punct .,modulate
R845 T3585 T3586 det a,program
R846 T3586 T3584 pobj program,by
R847 T3587 T3586 punct """",program
R848 T3532 T3533 nsubjpass Identification,identified
R849 T3588 T3589 npadvmod marker,assisted
R850 T3589 T3586 amod assisted,program
R851 T3590 T3589 punct -,assisted
R852 T3591 T3586 punct """",program
R853 T3534 T3532 prep of,Identification
R854 T3592 T3586 compound breeding,program
R855 T3593 T3594 advmod where,backcrossed
R856 T3594 T3586 relcl backcrossed,program
R857 T3535 T3536 amod novel,modulators
R858 T3595 T3596 det the,progeny
R859 T3596 T3594 nsubjpass progeny,backcrossed
R860 T3597 T3596 prep of,progeny
R861 T3598 T3599 det a,cross
R862 T3536 T3534 pobj modulators,of
R863 T3599 T3597 pobj cross,of
R864 T3600 T3599 nmod B6,cross
R865 T3537 T3536 cc and,modulators
R866 T3601 T3600 punct ×,B6
R867 T3602 T3603 compound A,J
R868 T3603 T3600 appos J,B6
R869 T3604 T3603 punct /,J
R870 T3538 T3536 conj factors,modulators
R871 T3605 T3594 auxpass were,backcrossed
R872 T3606 T3594 advmod successively,backcrossed
R873 T3607 T3594 prep to,backcrossed
R874 T3608 T3609 det the,mice
R875 T3609 T3607 pobj mice,to
R876 T3610 T3609 compound B6,mice
R877 T3539 T3536 prep of,modulators
R878 T3611 T3572 punct .,generated
R879 T3613 T3614 amod Genetic,markers
R880 T3540 T3541 det these,pathways
R881 T3614 T3615 nsubjpass markers,used
R882 T3541 T3539 pobj pathways,of
R883 T3616 T3615 auxpass were,used
R884 T3617 T3618 aux to,identify
R885 T3618 T3615 advcl identify,used
R886 T3619 T3618 dobj homozygosity,identify
R887 T3542 T3533 aux can,identified
R888 T3620 T3619 prep in,homozygosity
R889 T3621 T3622 det the,B6
R890 T3543 T3533 auxpass be,identified
R891 T3544 T3533 prep by,identified
R892 T3545 T3544 pcomp associating,by
R893 T3546 T3547 det the,phenotype
R894 T3622 T3620 pobj B6,in
R895 T3623 T3622 nmod background,B6
R896 T3624 T3622 punct (,B6
R897 T3547 T3545 dobj phenotype,associating
R898 T3625 T3622 punct ),B6
R899 T3626 T3622 cc and,B6
R900 T3548 T3545 prep with,associating
R901 T3627 T3628 det the,J
R902 T3628 T3632 compound J,chromosome
R903 T3629 T3628 amod individual,J
R904 T3549 T3550 det a,location
R905 T3630 T3628 compound A,J
R906 T3631 T3628 punct /,J
R907 T3632 T3622 conj chromosome,B6
R908 T3550 T3548 pobj location,with
R909 T3633 T3615 punct .,used
R910 T3551 T3550 punct (,location
R911 T3552 T3550 nmod s,location
R912 T3635 T3636 det These,strains
R913 T3553 T3550 punct ),location
R914 T3636 T3637 nsubj strains,have
R915 T3554 T3550 prep on,location
R916 T3638 T3639 nummod one,chromosome
R917 T3639 T3637 dobj chromosome,have
R918 T3640 T3639 prep from,chromosome
R919 T3555 T3556 det a,chromosome
R920 T3641 T3642 compound A,J
R921 T3642 T3644 compound J,mice
R922 T3643 T3642 punct /,J
R923 T3556 T3554 pobj chromosome,on
R924 T3644 T3640 pobj mice,from
R925 T3645 T3637 prep in,have
R926 T3646 T3647 det a,background
R927 T3647 T3645 pobj background,in
R928 T3648 T3647 compound B6,background
R929 T3557 T3556 amod specific,chromosome
R930 T3649 T3637 punct .,have
R931 T3651 T3652 nsubj This,allows
R932 T3558 T3550 punct ", ",location
R933 T3653 T3654 det the,identification
R934 T3654 T3652 dobj identification,allows
R935 T3559 T3560 det a,locus
R936 T3655 T3654 prep of,identification
R937 T3656 T3657 det a,trait
R938 T3657 T3655 pobj trait,of
R939 T3560 T3550 appos locus,location
R940 T3658 T3657 prep in,trait
R941 T3659 T3660 nummod one,CSS
R942 T3561 T3560 amod quantitative,locus
R943 T3660 T3658 pobj CSS,in
R944 T3661 T3659 cc or,one
R945 T3662 T3659 conj more,one
R946 T3562 T3560 compound trait,locus
R947 T3663 T3652 cc and,allows
R948 T3664 T3652 conj implies,allows
R949 T3563 T3560 punct (,locus
R950 T3665 T3666 mark that,resides
R951 T3666 T3664 ccomp resides,implies
R952 T3667 T3668 advmod at,one
R953 T3564 T3560 appos QTL,locus
R954 T3668 T3670 nummod one,QTL
R955 T3669 T3668 advmod least,one
R956 T3670 T3666 nsubj QTL,resides
R957 T3565 T3533 punct ),identified
R958 T3671 T3666 prep on,resides
R959 T3672 T3673 det this,chromosome
R960 T3673 T3671 pobj chromosome,on
R961 T3566 T3533 punct .,identified
R962 T3674 T3652 punct .,allows
R963 T3676 T3677 nsubj Use,requires
R964 T3728 T3714 punct .,simplify
R965 T3678 T3676 prep of,Use
R966 T3679 T3680 det this,panel
R967 T3680 T3678 pobj panel,of
R968 T3730 T3731 amod Several,studies
R969 T3681 T3682 amod fewer,mice
R970 T3682 T3677 dobj mice,requires
R971 T3683 T3684 aux to,determine
R972 T3684 T3677 advcl determine,requires
R973 T3685 T3686 det the,QTL
R974 T3731 T3732 nsubjpass studies,reported
R975 T3686 T3684 dobj QTL,determine
R976 T3687 T3688 mark than,does
R977 T3688 T3677 advcl does,requires
R978 T3689 T3690 det a,scan
R979 T3690 T3688 nsubj scan,does
R980 T3691 T3692 npadvmod genome,wide
R981 T3692 T3690 amod wide,scan
R982 T3733 T3731 prep of,studies
R983 T3693 T3692 punct -,wide
R984 T3694 T3677 punct .,requires
R985 T3696 T3697 det Another,advantage
R986 T3734 T3735 det this,panel
R987 T3697 T3698 nsubj advantage,is
R988 T3699 T3700 det the,ability
R989 T3735 T3733 pobj panel,of
R990 T3700 T3698 attr ability,is
R991 T3701 T3700 prep for,ability
R992 T3702 T3701 pobj detection,for
R993 T3703 T3702 prep of,detection
R994 T3736 T3735 compound CSS,panel
R995 T3704 T3703 pobj QTL,of
R996 T3705 T3702 prep in,detection
R997 T3706 T3707 det the,presence
R998 T3737 T3735 punct ", ",panel
R999 T3707 T3705 pobj presence,in