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PMC:1584416 / 9845-13784 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T1954 0-1 `` denotes “
T1956 1-5 JJ denotes Null
T1957 5-6 '' denotes ”
T1955 7-13 NN denotes Allele
T1959 14-17 MD denotes Can
T1958 18-27 VB denotes Alleviate
T1960 28-41 JJ denotes Developmental
T1961 42-47 NN denotes Delay
T1962 47-49 , denotes ,
T1963 49-53 NN denotes Skin
T1965 53-55 , denotes ,
T1966 55-58 CC denotes and
T1967 59-63 NN denotes Hair
T1964 64-72 NNS denotes Features
T1968 73-75 IN denotes of
T1969 76-79 NN denotes TTD
T1970 79-301 sentence denotes To test the potential of a homozygous lethal “null” allele to nevertheless contribute to organismal phenotype, we combined an Xpd†XPCS allele with a viable XpdTTD allele by crossing the corresponding heterozygous animals.
T1971 80-82 TO denotes To
T1972 83-87 VB denotes test
T1974 88-91 DT denotes the
T1975 92-101 NN denotes potential
T1976 102-104 IN denotes of
T1977 105-106 DT denotes a
T1979 107-117 JJ denotes homozygous
T1980 118-124 JJ denotes lethal
T1981 125-126 `` denotes “
T1982 126-130 JJ denotes null
T1983 130-131 '' denotes ”
T1978 132-138 NN denotes allele
T1984 139-141 TO denotes to
T1986 142-154 RB denotes nevertheless
T1985 155-165 VB denotes contribute
T1987 166-168 IN denotes to
T1988 169-179 JJ denotes organismal
T1989 180-189 NN denotes phenotype
T1990 189-191 , denotes ,
T1991 191-193 PRP denotes we
T1973 194-202 VBD denotes combined
T1992 203-205 DT denotes an
T1994 206-214 NN denotes Xpd†XPCS
T1993 215-221 NN denotes allele
T1995 222-226 IN denotes with
T1996 227-228 DT denotes a
T1998 229-235 JJ denotes viable
T1999 236-242 NN denotes XpdTTD
T1997 243-249 NN denotes allele
T2000 250-252 IN denotes by
T2001 253-261 VBG denotes crossing
T2002 262-265 DT denotes the
T2004 266-279 VBG denotes corresponding
T2005 280-292 JJ denotes heterozygous
T2003 293-300 NNS denotes animals
T2006 300-301 . denotes .
T2007 301-472 sentence denotes Similar to hemizygous TTD mice carrying one true Xpd knockout allele (XpdTTD/KO), compound heterozygous XpdTTD/†XPCS mice were born at the expected Mendelian frequencies.
T2008 302-309 JJ denotes Similar
T2010 310-312 IN denotes to
T2011 313-323 JJ denotes hemizygous
T2013 324-327 NN denotes TTD
T2012 328-332 NNS denotes mice
T2014 333-341 VBG denotes carrying
T2015 342-345 CD denotes one
T2017 346-350 JJ denotes true
T2018 351-354 NN denotes Xpd
T2019 355-363 NN denotes knockout
T2016 364-370 NN denotes allele
T2020 371-372 -LRB- denotes (
T2022 372-378 NN denotes XpdTTD
T2023 378-379 HYPH denotes /
T2021 379-381 NN denotes KO
T2024 381-382 -RRB- denotes )
T2025 382-384 , denotes ,
T2026 384-392 NN denotes compound
T2028 393-405 JJ denotes heterozygous
T2029 406-412 NN denotes XpdTTD
T2031 412-413 HYPH denotes /
T2030 413-418 NN denotes †XPCS
T2027 419-423 NNS denotes mice
T2032 424-428 VBD denotes were
T2009 429-433 VBN denotes born
T2033 434-436 IN denotes at
T2034 437-440 DT denotes the
T2036 441-449 VBN denotes expected
T2037 450-459 JJ denotes Mendelian
T2035 460-471 NNS denotes frequencies
T2038 471-472 . denotes .
T2039 472-668 sentence denotes Expression from the Xpd†XPCS allele was also reduced in the testis of compound heterozygous animals, whereas expression from the XpdTTD allele was increased relative to wt by ~5-fold (Figure 1E).
T2040 473-483 NN denotes Expression
T2042 484-488 IN denotes from
T2043 489-492 DT denotes the
T2045 493-501 NN denotes Xpd†XPCS
T2044 502-508 NN denotes allele
T2046 509-512 VBD denotes was
T2047 513-517 RB denotes also
T2041 518-525 VBN denotes reduced
T2048 526-528 IN denotes in
T2049 529-532 DT denotes the
T2050 533-539 NN denotes testis
T2051 540-542 IN denotes of
T2052 543-551 NN denotes compound
T2054 552-564 JJ denotes heterozygous
T2053 565-572 NNS denotes animals
T2055 572-574 , denotes ,
T2056 574-581 IN denotes whereas
T2058 582-592 NN denotes expression
T2059 593-597 IN denotes from
T2060 598-601 DT denotes the
T2062 602-608 NN denotes XpdTTD
T2061 609-615 NN denotes allele
T2063 616-619 VBD denotes was
T2057 620-629 VBN denotes increased
T2064 630-638 JJ denotes relative
T2065 639-641 IN denotes to
T2066 642-644 NN denotes wt
T2067 645-647 IN denotes by
T2068 648-649 SYM denotes ~
T2069 649-655 RB denotes 5-fold
T2070 656-657 -LRB- denotes (
T2072 657-663 NN denotes Figure
T2071 664-666 NN denotes 1E
T2073 666-667 -RRB- denotes )
T2074 667-668 . denotes .
T2075 668-921 sentence denotes Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles.
T2076 669-676 IN denotes Because
T2078 677-679 IN denotes of
T2079 680-681 DT denotes a
T2080 682-686 NN denotes lack
T2081 687-689 IN denotes of
T2082 690-699 JJ denotes available
T2083 700-710 NNS denotes antibodies
T2084 711-714 CC denotes and
T2085 715-718 DT denotes the
T2086 719-728 NN denotes inability
T2087 729-731 TO denotes to
T2088 732-743 VB denotes distinguish
T2089 744-751 IN denotes amongst
T2090 752-759 JJ denotes various
T2092 760-766 JJ denotes mutant
T2091 767-772 NNS denotes forms
T2093 773-775 IN denotes of
T2094 776-779 NN denotes XPD
T2095 780-789 VBG denotes differing
T2096 790-794 RB denotes only
T2097 795-797 IN denotes by
T2098 798-804 JJ denotes single
T2100 805-810 NN denotes amino
T2101 811-815 NN denotes acid
T2099 816-829 NNS denotes substitutions
T2102 829-831 , denotes ,
T2103 831-833 PRP denotes we
T2077 834-838 VBD denotes were
T2104 839-845 JJ denotes unable
T2105 846-848 TO denotes to
T2106 849-858 VB denotes ascertain
T2107 859-862 DT denotes the
T2109 863-871 JJ denotes relative
T2108 872-878 NN denotes amount
T2110 879-881 IN denotes of
T2111 882-885 NN denotes XPD
T2112 886-893 NN denotes protein
T2113 894-898 IN denotes from
T2114 899-902 DT denotes the
T2116 903-912 JJ denotes different
T2115 913-920 NNS denotes alleles
T2117 920-921 . denotes .
T2118 921-1228 sentence denotes Despite reduced levels of mRNA expression, the homozygous lethal Xpd†XPCS allele ameliorated multiple XpdTTD-associated disease symptoms in compound heterozygous XpdTTD/†XPCS animals including the hallmark brittle hair and cutaneous features fully penetrant in homo- and hemizygous TTD mice (Figure 2A–2C).
T2119 922-929 IN denotes Despite
T2121 930-937 VBN denotes reduced
T2122 938-944 NNS denotes levels
T2123 945-947 IN denotes of
T2124 948-952 NN denotes mRNA
T2125 953-963 NN denotes expression
T2126 963-965 , denotes ,
T2127 965-968 DT denotes the
T2129 969-979 JJ denotes homozygous
T2130 980-986 JJ denotes lethal
T2131 987-995 NN denotes Xpd†XPCS
T2128 996-1002 NN denotes allele
T2120 1003-1014 VBD denotes ameliorated
T2132 1015-1023 JJ denotes multiple
T2134 1024-1030 NN denotes XpdTTD
T2136 1030-1031 HYPH denotes -
T2135 1031-1041 JJ denotes associated
T2137 1042-1049 NN denotes disease
T2133 1050-1058 NNS denotes symptoms
T2138 1059-1061 IN denotes in
T2139 1062-1070 JJ denotes compound
T2141 1071-1083 JJ denotes heterozygous
T2142 1084-1090 NN denotes XpdTTD
T2144 1090-1091 HYPH denotes /
T2143 1091-1096 NN denotes †XPCS
T2140 1097-1104 NNS denotes animals
T2145 1105-1114 VBG denotes including
T2146 1115-1118 DT denotes the
T2148 1119-1127 NN denotes hallmark
T2149 1128-1135 JJ denotes brittle
T2147 1136-1140 NN denotes hair
T2150 1141-1144 CC denotes and
T2151 1145-1154 JJ denotes cutaneous
T2152 1155-1163 NNS denotes features
T2153 1164-1169 RB denotes fully
T2154 1170-1179 JJ denotes penetrant
T2155 1180-1182 IN denotes in
T2156 1183-1187 AFX denotes homo
T2158 1187-1188 HYPH denotes -
T2159 1189-1192 CC denotes and
T2157 1193-1203 JJ denotes hemizygous
T2161 1204-1207 NN denotes TTD
T2160 1208-1212 NNS denotes mice
T2162 1213-1214 -LRB- denotes (
T2164 1214-1220 NN denotes Figure
T2163 1221-1223 NN denotes 2A
T2165 1223-1224 SYM denotes –
T2166 1224-1226 NN denotes 2C
T2167 1226-1227 -RRB- denotes )
T2168 1227-1228 . denotes .
T2169 1228-1552 sentence denotes In marked contrast to XpdTTD/TTD (and XpdTTD/KO) mice, which display complete hair loss in the first hair cycle and partial hair loss in subsequent cycles throughout their lives [21], compound heterozygous XpdTTD/†XPCS mice displayed some hair loss only during the first hair cycle and only locally at the back (Figure 2A).
T2170 1229-1231 IN denotes In
T2172 1232-1238 JJ denotes marked
T2173 1239-1247 NN denotes contrast
T2174 1248-1250 IN denotes to
T2175 1251-1257 NN denotes XpdTTD
T2177 1257-1258 HYPH denotes /
T2176 1258-1261 NN denotes TTD
T2179 1262-1263 -LRB- denotes (
T2180 1263-1266 CC denotes and
T2181 1267-1273 NN denotes XpdTTD
T2183 1273-1274 HYPH denotes /
T2182 1274-1276 NN denotes KO
T2184 1276-1277 -RRB- denotes )
T2178 1278-1282 NNS denotes mice
T2185 1282-1284 , denotes ,
T2186 1284-1289 WDT denotes which
T2187 1290-1297 VBP denotes display
T2188 1298-1306 JJ denotes complete
T2190 1307-1311 NN denotes hair
T2189 1312-1316 NN denotes loss
T2191 1317-1319 IN denotes in
T2192 1320-1323 DT denotes the
T2194 1324-1329 JJ denotes first
T2195 1330-1334 NN denotes hair
T2193 1335-1340 NN denotes cycle
T2196 1341-1344 CC denotes and
T2197 1345-1352 JJ denotes partial
T2199 1353-1357 NN denotes hair
T2198 1358-1362 NN denotes loss
T2200 1363-1365 IN denotes in
T2201 1366-1376 JJ denotes subsequent
T2202 1377-1383 NNS denotes cycles
T2203 1384-1394 IN denotes throughout
T2204 1395-1400 PRP$ denotes their
T2205 1401-1406 NNS denotes lives
T2206 1407-1408 -LRB- denotes [
T2207 1408-1410 CD denotes 21
T2208 1410-1411 -RRB- denotes ]
T2209 1411-1413 , denotes ,
T2210 1413-1421 NN denotes compound
T2212 1422-1434 JJ denotes heterozygous
T2213 1435-1447 NN denotes XpdTTD/†XPCS
T2211 1448-1452 NNS denotes mice
T2171 1453-1462 VBD denotes displayed
T2214 1463-1467 DT denotes some
T2216 1468-1472 NN denotes hair
T2215 1473-1477 NN denotes loss
T2217 1478-1482 RB denotes only
T2218 1483-1489 IN denotes during
T2219 1490-1493 DT denotes the
T2221 1494-1499 JJ denotes first
T2222 1500-1504 NN denotes hair
T2220 1505-1510 NN denotes cycle
T2223 1511-1514 CC denotes and
T2224 1515-1519 RB denotes only
T2225 1520-1527 RB denotes locally
T2226 1528-1530 IN denotes at
T2227 1531-1534 DT denotes the
T2228 1535-1539 NN denotes back
T2229 1540-1541 -LRB- denotes (
T2231 1541-1547 NN denotes Figure
T2230 1548-1550 NN denotes 2A
T2232 1550-1551 -RRB- denotes )
T2233 1551-1552 . denotes .
T2234 1552-1746 sentence denotes Scanning electron microscope analysis of XpdTTD/†XPCS hair revealed an almost normal appearance, with TTD-like features such as broken hairs found only at very low frequency (unpublished data).
T2235 1553-1561 NN denotes Scanning
T2237 1562-1570 NN denotes electron
T2236 1571-1581 NN denotes microscope
T2238 1582-1590 NN denotes analysis
T2240 1591-1593 IN denotes of
T2241 1594-1600 NN denotes XpdTTD
T2243 1600-1601 HYPH denotes /
T2242 1601-1606 NN denotes †XPCS
T2244 1607-1611 NN denotes hair
T2239 1612-1620 VBD denotes revealed
T2245 1621-1623 DT denotes an
T2247 1624-1630 RB denotes almost
T2248 1631-1637 JJ denotes normal
T2246 1638-1648 NN denotes appearance
T2249 1648-1650 , denotes ,
T2250 1650-1654 IN denotes with
T2251 1655-1658 NN denotes TTD
T2253 1658-1659 HYPH denotes -
T2252 1659-1663 JJ denotes like
T2254 1664-1672 NNS denotes features
T2255 1673-1677 JJ denotes such
T2256 1678-1680 IN denotes as
T2257 1681-1687 JJ denotes broken
T2258 1688-1693 NNS denotes hairs
T2259 1694-1699 VBN denotes found
T2260 1700-1704 RB denotes only
T2261 1705-1707 IN denotes at
T2262 1708-1712 RB denotes very
T2263 1713-1716 JJ denotes low
T2264 1717-1726 NN denotes frequency
T2265 1727-1728 -LRB- denotes (
T2267 1728-1739 JJ denotes unpublished
T2266 1740-1744 NNS denotes data
T2268 1744-1745 -RRB- denotes )
T2269 1745-1746 . denotes .
T2270 1746-1933 sentence denotes Amino acid analysis confirmed that cysteine levels in the hair of the XpdTTD/†XPCS mice were significantly higher than in XpdTTD/TTD animals, but remained below the wt level (Figure 2C).
T2271 1747-1752 NN denotes Amino
T2272 1753-1757 NN denotes acid
T2273 1758-1766 NN denotes analysis
T2274 1767-1776 VBD denotes confirmed
T2275 1777-1781 IN denotes that
T2277 1782-1790 NN denotes cysteine
T2278 1791-1797 NNS denotes levels
T2279 1798-1800 IN denotes in
T2280 1801-1804 DT denotes the
T2281 1805-1809 NN denotes hair
T2282 1810-1812 IN denotes of
T2283 1813-1816 DT denotes the
T2285 1817-1823 NN denotes XpdTTD
T2287 1823-1824 HYPH denotes /
T2286 1824-1829 NN denotes †XPCS
T2284 1830-1834 NNS denotes mice
T2276 1835-1839 VBD denotes were
T2288 1840-1853 RB denotes significantly
T2289 1854-1860 JJR denotes higher
T2290 1861-1865 IN denotes than
T2291 1866-1868 IN denotes in
T2292 1869-1875 NN denotes XpdTTD
T2294 1875-1876 HYPH denotes /
T2293 1876-1879 NN denotes TTD
T2295 1880-1887 NNS denotes animals
T2296 1887-1889 , denotes ,
T2297 1889-1892 CC denotes but
T2298 1893-1901 VBD denotes remained
T2299 1902-1907 IN denotes below
T2300 1908-1911 DT denotes the
T2302 1912-1914 NN denotes wt
T2301 1915-1920 NN denotes level
T2303 1921-1922 -LRB- denotes (
T2305 1922-1928 NN denotes Figure
T2304 1929-1931 NN denotes 2C
T2306 1931-1932 -RRB- denotes )
T2307 1932-1933 . denotes .
T2308 1933-2081 sentence denotes TTD hemizygotes (XpdTTD/KO) do not display significant differences in cutaneous features and longevity relative to homozygous XpdTTD/TTD mice [21].
T2309 1934-1937 NN denotes TTD
T2310 1938-1949 NNS denotes hemizygotes
T2312 1950-1951 -LRB- denotes (
T2314 1951-1957 NN denotes XpdTTD
T2315 1957-1958 HYPH denotes /
T2313 1958-1960 NN denotes KO
T2316 1960-1961 -RRB- denotes )
T2317 1962-1964 VBP denotes do
T2318 1965-1968 RB denotes not
T2311 1969-1976 VB denotes display
T2319 1977-1988 JJ denotes significant
T2320 1989-2000 NNS denotes differences
T2321 2001-2003 IN denotes in
T2322 2004-2013 JJ denotes cutaneous
T2323 2014-2022 NNS denotes features
T2324 2023-2026 CC denotes and
T2325 2027-2036 NN denotes longevity
T2326 2037-2045 JJ denotes relative
T2327 2046-2048 IN denotes to
T2328 2049-2059 JJ denotes homozygous
T2330 2060-2066 NN denotes XpdTTD
T2332 2066-2067 HYPH denotes /
T2331 2067-2070 NN denotes TTD
T2329 2071-2075 NNS denotes mice
T2333 2076-2077 -LRB- denotes [
T2334 2077-2079 CD denotes 21
T2335 2079-2080 -RRB- denotes ]
T2336 2080-2081 . denotes .
T2337 2081-3741 sentence denotes Figure 2 Partial Rescue of TTD Cutaneous, Blood, and Developmental Phenotypes in Compound Heterozygous XpdTTD/†XPCS Mice (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice. Insets: images of first-round hair loss. (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice. TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice. Magnification 400×. (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice. The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice. Error bars indicate standard error of the mean (SEM). (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice. The p-values indicate the significance of the difference relative to wt. Error bars indicate SEM. (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%). Error bars indicate SEM. Other prominent TTD features in the epidermis, including acanthosis (thickening of the layer of the nucleated cells), hyperkeratosis (prominent thickening of the cornified layer), and pronounced granular layer and sebacious gland hyperplasia (causing greasy appearance of the hair), were absent in the skin of XpdTTD/†XPCS mice, as established by blind microscopic examination of skin sections (Figure 2B).
T7658 2092-2099 JJ denotes Partial
T7659 2100-2106 NN denotes Rescue
T7660 2107-2109 IN denotes of
T7661 2110-2113 NN denotes TTD
T7662 2114-2123 JJ denotes Cutaneous
T7663 2123-2125 , denotes ,
T7664 2125-2130 NN denotes Blood
T7665 2130-2132 , denotes ,
T7666 2132-2135 CC denotes and
T7667 2136-2149 JJ denotes Developmental
T7668 2150-2160 NNS denotes Phenotypes
T7669 2161-2163 IN denotes in
T7670 2164-2172 NN denotes Compound
T7672 2173-2185 JJ denotes Heterozygous
T7673 2186-2192 NN denotes XpdTTD
T7675 2192-2193 HYPH denotes /
T7674 2193-2198 NN denotes †XPCS
T7671 2199-2203 NNS denotes Mice
T7676 2203-2303 sentence denotes (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice.
T7677 2204-2205 -LRB- denotes (
T7678 2205-2206 LS denotes A
T7680 2206-2207 -RRB- denotes )
T7679 2208-2219 NNS denotes Photographs
T7681 2220-2222 IN denotes of
T7682 2223-2224 CD denotes 5
T7684 2224-2225 HYPH denotes -
T7683 2225-2227 NN denotes mo
T7686 2227-2228 HYPH denotes -
T7685 2228-2231 JJ denotes old
T7688 2232-2242 JJ denotes homozygous
T7690 2243-2249 NN denotes XpdTTD
T7691 2249-2250 HYPH denotes /
T7689 2250-2253 NN denotes TTD
T7692 2253-2255 , denotes ,
T7693 2255-2263 NN denotes compound
T7695 2264-2276 JJ denotes heterozygous
T7696 2277-2283 NN denotes XpdTTD
T7697 2283-2284 HYPH denotes /
T7694 2284-2289 NN denotes †XPCS
T7698 2289-2291 , denotes ,
T7699 2291-2294 CC denotes and
T7700 2295-2297 NN denotes wt
T7687 2298-2302 NNS denotes mice
T7701 2302-2303 . denotes .
T7702 2303-2344 sentence denotes Insets: images of first-round hair loss.
T7703 2304-2310 NNS denotes Insets
T7704 2310-2312 : denotes :
T7705 2312-2318 NNS denotes images
T7706 2319-2321 IN denotes of
T7707 2322-2327 JJ denotes first
T7709 2327-2328 HYPH denotes -
T7708 2328-2333 NN denotes round
T7711 2334-2338 NN denotes hair
T7710 2339-2343 NN denotes loss
T7712 2343-2344 . denotes .
T7713 2344-2424 sentence denotes (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice.
T7714 2345-2346 -LRB- denotes (
T7715 2346-2347 LS denotes B
T7717 2347-2348 -RRB- denotes )
T7718 2349-2361 JJ denotes Histological
T7716 2362-2370 NN denotes analysis
T7719 2371-2373 IN denotes of
T7720 2374-2377 DT denotes the
T7721 2378-2382 NN denotes skin
T7722 2383-2385 IN denotes of
T7723 2386-2392 NN denotes XpdTTD
T7725 2392-2393 HYPH denotes /
T7724 2393-2396 NN denotes TTD
T7727 2396-2398 , denotes ,
T7728 2398-2404 NN denotes XpdTTD
T7730 2404-2405 HYPH denotes /
T7729 2405-2410 NN denotes †XPCS
T7731 2410-2412 , denotes ,
T7732 2412-2415 CC denotes and
T7733 2416-2418 NN denotes wt
T7726 2419-2423 NNS denotes mice
T7734 2423-2424 . denotes .
T7735 2424-2680 sentence denotes TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice.
T7736 2425-2428 NN denotes TTD
T7738 2428-2429 HYPH denotes -
T7737 2429-2439 JJ denotes associated
T7739 2440-2450 NN denotes acanthosis
T7741 2451-2452 -LRB- denotes (
T7743 2452-2459 JJR denotes thicker
T7742 2460-2469 NN denotes epidermis
T7744 2469-2471 , denotes ,
T7745 2471-2480 VBN denotes indicated
T7746 2481-2483 IN denotes by
T7747 2484-2489 JJ denotes solid
T7749 2490-2498 JJ denotes vertical
T7748 2499-2503 NN denotes line
T7750 2503-2504 -RRB- denotes )
T7751 2504-2506 , denotes ,
T7752 2506-2516 VBN denotes pronounced
T7754 2517-2525 JJ denotes granular
T7753 2526-2531 NN denotes layer
T7755 2532-2533 -LRB- denotes (
T7756 2533-2542 VBN denotes indicated
T7757 2543-2545 IN denotes by
T7758 2546-2552 NNS denotes arrows
T7759 2552-2553 -RRB- denotes )
T7760 2553-2555 , denotes ,
T7761 2555-2558 CC denotes and
T7762 2559-2568 JJ denotes sebacious
T7764 2569-2574 NN denotes gland
T7763 2575-2586 NN denotes hyperplasia
T7765 2587-2588 -LRB- denotes (
T7766 2588-2597 VBN denotes indicated
T7767 2598-2600 IN denotes by
T7768 2601-2607 VBN denotes dotted
T7770 2608-2616 JJ denotes vertical
T7769 2617-2621 NN denotes line
T7771 2621-2622 -RRB- denotes )
T7740 2623-2627 VBD denotes were
T7772 2628-2634 JJ denotes absent
T7773 2635-2637 IN denotes in
T7774 2638-2641 DT denotes the
T7775 2642-2651 NN denotes epidermis
T7776 2652-2654 IN denotes of
T7777 2655-2661 NN denotes XpdTTD
T7779 2661-2662 HYPH denotes /
T7778 2662-2667 NN denotes †XPCS
T7781 2668-2671 CC denotes and
T7782 2672-2674 NN denotes wt
T7780 2675-2679 NNS denotes mice
T7783 2679-2680 . denotes .
T7784 2680-2700 sentence denotes Magnification 400×.
T7785 2681-2694 NN denotes Magnification
T7786 2695-2698 CD denotes 400
T7787 2698-2699 SYM denotes ×
T7788 2699-2700 . denotes .
T7789 2700-2773 sentence denotes (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice.
T7790 2701-2702 -LRB- denotes (
T7791 2702-2703 LS denotes C
T7793 2703-2704 -RRB- denotes )
T7794 2705-2713 NN denotes Cysteine
T7792 2714-2721 NN denotes content
T7795 2722-2724 IN denotes of
T7796 2725-2729 NN denotes hair
T7797 2730-2734 IN denotes from
T7798 2735-2737 NN denotes wt
T7800 2737-2739 , denotes ,
T7801 2739-2745 NN denotes XpdTTD
T7803 2745-2746 HYPH denotes /
T7802 2746-2749 NN denotes TTD
T7804 2749-2751 , denotes ,
T7805 2751-2754 CC denotes and
T7806 2755-2761 NN denotes XpdTTD
T7808 2761-2762 HYPH denotes /
T7807 2762-2767 NN denotes †XPCS
T7799 2768-2772 NNS denotes mice
T7809 2772-2773 . denotes .
T7810 2773-2896 sentence denotes The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice.
T7811 2774-2777 DT denotes The
T7813 2778-2779 NN denotes p
T7814 2779-2780 HYPH denotes -
T7812 2780-2785 NN denotes value
T7815 2786-2795 VBZ denotes indicates
T7816 2796-2807 JJ denotes significant
T7817 2808-2819 NNS denotes differences
T7818 2820-2827 IN denotes between
T7819 2828-2835 NNS denotes mutants
T7820 2836-2839 CC denotes and
T7821 2840-2842 NN denotes wt
T7822 2842-2844 , denotes ,
T7823 2844-2846 RB denotes as
T7825 2847-2851 RB denotes well
T7824 2852-2854 IN denotes as
T7826 2855-2862 IN denotes between
T7827 2863-2869 NN denotes XpdTTD
T7829 2869-2870 HYPH denotes /
T7828 2870-2873 NN denotes TTD
T7831 2874-2877 CC denotes and
T7832 2878-2884 NN denotes XpdTTD
T7834 2884-2885 HYPH denotes /
T7833 2885-2890 NN denotes †XPCS
T7830 2891-2895 NNS denotes mice
T7835 2895-2896 . denotes .
T7836 2896-2950 sentence denotes Error bars indicate standard error of the mean (SEM).
T7837 2897-2902 NN denotes Error
T7838 2903-2907 NNS denotes bars
T7839 2908-2916 VBP denotes indicate
T7840 2917-2925 JJ denotes standard
T7841 2926-2931 NN denotes error
T7842 2932-2934 IN denotes of
T7843 2935-2938 DT denotes the
T7844 2939-2943 NN denotes mean
T7845 2944-2945 -LRB- denotes (
T7846 2945-2948 NN denotes SEM
T7847 2948-2949 -RRB- denotes )
T7848 2949-2950 . denotes .
T7849 2950-3020 sentence denotes (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice.
T7850 2951-2952 -LRB- denotes (
T7851 2952-2953 LS denotes D
T7853 2953-2954 -RRB- denotes )
T7854 2955-2965 NN denotes Hematocrit
T7852 2966-2972 NNS denotes values
T7855 2973-2977 IN denotes from
T7856 2978-2983 NN denotes blood
T7857 2984-2986 IN denotes of
T7858 2987-2993 NN denotes XpdTTD
T7860 2993-2994 HYPH denotes /
T7859 2994-2997 NN denotes TTD
T7862 2998-3001 CC denotes and
T7863 3002-3008 NN denotes XpdTTD
T7865 3008-3009 HYPH denotes /
T7864 3009-3014 NN denotes †XPCS
T7861 3015-3019 NNS denotes mice
T7866 3019-3020 . denotes .
T7867 3020-3093 sentence denotes The p-values indicate the significance of the difference relative to wt.
T7868 3021-3024 DT denotes The
T7870 3025-3026 NN denotes p
T7871 3026-3027 HYPH denotes -
T7869 3027-3033 NNS denotes values
T7872 3034-3042 VBP denotes indicate
T7873 3043-3046 DT denotes the
T7874 3047-3059 NN denotes significance
T7875 3060-3062 IN denotes of
T7876 3063-3066 DT denotes the
T7877 3067-3077 NN denotes difference
T7878 3078-3086 JJ denotes relative
T7879 3087-3089 IN denotes to
T7880 3090-3092 NN denotes wt
T7881 3092-3093 . denotes .
T7882 3093-3118 sentence denotes Error bars indicate SEM.
T7883 3094-3099 NN denotes Error
T7884 3100-3104 NNS denotes bars
T7885 3105-3113 VBP denotes indicate
T7886 3114-3117 NN denotes SEM
T7887 3117-3118 . denotes .
T7888 3118-3309 sentence denotes (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%).
T7889 3119-3120 -LRB- denotes (
T7890 3120-3121 LS denotes E
T7892 3121-3122 -RRB- denotes )
T7893 3123-3127 NN denotes Body
T7891 3128-3135 NNS denotes weights
T7894 3136-3138 IN denotes of
T7895 3139-3149 VBG denotes developing
T7897 3150-3156 NN denotes XpdTTD
T7899 3156-3157 HYPH denotes /
T7898 3157-3160 NN denotes TTD
T7900 3161-3164 CC denotes and
T7901 3165-3171 NN denotes XpdTTD
T7903 3171-3172 HYPH denotes /
T7902 3172-3177 NN denotes †XPCS
T7896 3178-3182 NNS denotes mice
T7904 3183-3188 IN denotes after
T7905 3189-3196 VBG denotes weaning
T7906 3197-3204 VBN denotes plotted
T7907 3205-3207 IN denotes as
T7908 3208-3209 DT denotes a
T7909 3210-3220 NN denotes percentage
T7910 3221-3223 IN denotes of
T7911 3224-3227 DT denotes the
T7912 3228-3234 NN denotes weight
T7913 3235-3237 IN denotes of
T7914 3238-3241 NN denotes age
T7916 3241-3242 HYPH denotes -
T7915 3242-3249 JJ denotes matched
T7918 3250-3257 NN denotes control
T7919 3258-3260 NN denotes wt
T7920 3261-3264 CC denotes and
T7921 3265-3277 NN denotes heterozygote
T7922 3278-3279 -LRB- denotes (
T7923 3279-3281 NN denotes hz
T7924 3281-3282 -RRB- denotes )
T7917 3283-3294 NNS denotes littermates
T7925 3295-3296 -LRB- denotes (
T7926 3296-3299 VBN denotes set
T7927 3300-3302 IN denotes at
T7928 3303-3306 CD denotes 100
T7929 3306-3307 NN denotes %
T7930 3307-3308 -RRB- denotes )
T7931 3308-3309 . denotes .
T7932 3309-3334 sentence denotes Error bars indicate SEM.
T7933 3310-3315 NN denotes Error
T7934 3316-3320 NNS denotes bars
T7935 3321-3329 VBP denotes indicate
T7936 3330-3333 NN denotes SEM
T7937 3333-3334 . denotes .
T2338 3335-3340 JJ denotes Other
T2340 3341-3350 JJ denotes prominent
T2341 3351-3354 NN denotes TTD
T2339 3355-3363 NNS denotes features
T2343 3364-3366 IN denotes in
T2344 3367-3370 DT denotes the
T2345 3371-3380 NN denotes epidermis
T2346 3380-3382 , denotes ,
T2347 3382-3391 VBG denotes including
T2348 3392-3402 NN denotes acanthosis
T2349 3403-3404 -LRB- denotes (
T2350 3404-3414 VBG denotes thickening
T2351 3415-3417 IN denotes of
T2352 3418-3421 DT denotes the
T2353 3422-3427 NN denotes layer
T2354 3428-3430 IN denotes of
T2355 3431-3434 DT denotes the
T2357 3435-3444 JJ denotes nucleated
T2356 3445-3450 NNS denotes cells
T2358 3450-3451 -RRB- denotes )
T2359 3451-3453 , denotes ,
T2360 3453-3467 NN denotes hyperkeratosis
T2361 3468-3469 -LRB- denotes (
T2363 3469-3478 JJ denotes prominent
T2362 3479-3489 NN denotes thickening
T2364 3490-3492 IN denotes of
T2365 3493-3496 DT denotes the
T2367 3497-3506 VBN denotes cornified
T2366 3507-3512 NN denotes layer
T2368 3512-3513 -RRB- denotes )
T2369 3513-3515 , denotes ,
T2370 3515-3518 CC denotes and
T2371 3519-3529 JJ denotes pronounced
T2373 3530-3538 JJ denotes granular
T2372 3539-3544 NN denotes layer
T2374 3545-3548 CC denotes and
T2375 3549-3558 JJ denotes sebacious
T2376 3559-3564 NN denotes gland
T2377 3565-3576 NN denotes hyperplasia
T2378 3577-3578 -LRB- denotes (
T2379 3578-3585 VBG denotes causing
T2380 3586-3592 JJ denotes greasy
T2381 3593-3603 NN denotes appearance
T2382 3604-3606 IN denotes of
T2383 3607-3610 DT denotes the
T2384 3611-3615 NN denotes hair
T2385 3615-3616 -RRB- denotes )
T2386 3616-3618 , denotes ,
T2342 3618-3622 VBD denotes were
T2387 3623-3629 JJ denotes absent
T2388 3630-3632 IN denotes in
T2389 3633-3636 DT denotes the
T2390 3637-3641 NN denotes skin
T2391 3642-3644 IN denotes of
T2392 3645-3651 NN denotes XpdTTD
T2394 3651-3652 HYPH denotes /
T2393 3652-3657 NN denotes †XPCS
T2395 3658-3662 NNS denotes mice
T2396 3662-3664 , denotes ,
T2397 3664-3666 IN denotes as
T2398 3667-3678 VBN denotes established
T2399 3679-3681 IN denotes by
T2400 3682-3687 JJ denotes blind
T2402 3688-3699 JJ denotes microscopic
T2401 3700-3711 NN denotes examination
T2403 3712-3714 IN denotes of
T2404 3715-3719 NN denotes skin
T2405 3720-3728 NNS denotes sections
T2406 3729-3730 -LRB- denotes (
T2408 3730-3736 NN denotes Figure
T2407 3737-3739 NN denotes 2B
T2409 3739-3740 -RRB- denotes )
T2410 3740-3741 . denotes .
T2411 3741-3939 sentence denotes Furthermore, anaemia and developmental delay present in patients with TTD [24] and in XpdTTD/TTD mice [15] were both partially rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 2D and 2E).
T2412 3742-3753 RB denotes Furthermore
T2414 3753-3755 , denotes ,
T2415 3755-3762 NN denotes anaemia
T2416 3763-3766 CC denotes and
T2417 3767-3780 JJ denotes developmental
T2418 3781-3786 NN denotes delay
T2419 3787-3794 JJ denotes present
T2420 3795-3797 IN denotes in
T2421 3798-3806 NNS denotes patients
T2422 3807-3811 IN denotes with
T2423 3812-3815 NN denotes TTD
T2424 3816-3817 -LRB- denotes [
T2425 3817-3819 CD denotes 24
T2426 3819-3820 -RRB- denotes ]
T2427 3821-3824 CC denotes and
T2428 3825-3827 IN denotes in
T2429 3828-3834 NN denotes XpdTTD
T2431 3834-3835 HYPH denotes /
T2430 3835-3838 NN denotes TTD
T2432 3839-3843 NNS denotes mice
T2433 3844-3845 -LRB- denotes [
T2434 3845-3847 CD denotes 15
T2435 3847-3848 -RRB- denotes ]
T2436 3849-3853 VBD denotes were
T2437 3854-3858 RB denotes both
T2438 3859-3868 RB denotes partially
T2413 3869-3876 VBN denotes rescued
T2439 3877-3879 IN denotes in
T2440 3880-3888 JJ denotes compound
T2442 3889-3901 JJ denotes heterozygous
T2443 3902-3908 NN denotes XpdTTD
T2445 3908-3909 HYPH denotes /
T2444 3909-3914 NN denotes †XPCS
T2441 3915-3919 NNS denotes mice
T2446 3920-3921 -LRB- denotes (
T2448 3921-3927 NN denotes Figure
T2447 3928-3930 NN denotes 2D
T2449 3931-3934 CC denotes and
T2450 3935-3937 NN denotes 2E
T2451 3937-3938 -RRB- denotes )
T2452 3938-3939 . denotes .
R1226 T1954 T1955 punct “,Allele
R1227 T1955 T1958 nsubj Allele,Alleviate
R1228 T1956 T1955 amod Null,Allele
R1229 T1957 T1955 punct ”,Allele
R1230 T1959 T1958 aux Can,Alleviate
R1231 T1960 T1961 amod Developmental,Delay
R1232 T1961 T1958 dobj Delay,Alleviate
R1233 T1962 T1961 punct ", ",Delay
R1234 T1963 T1964 nmod Skin,Features
R1235 T1964 T1961 appos Features,Delay
R1236 T1965 T1963 punct ", ",Skin
R1237 T1966 T1963 cc and,Skin
R1238 T1967 T1963 conj Hair,Skin
R1239 T1968 T1964 prep of,Features
R1240 T1969 T1968 pobj TTD,of
R1241 T1971 T1972 aux To,test
R1242 T1972 T1973 advcl test,combined
R1243 T1974 T1975 det the,potential
R1244 T1975 T1972 dobj potential,test
R1245 T1976 T1975 prep of,potential
R1246 T1977 T1978 det a,allele
R1247 T1978 T1976 pobj allele,of
R1248 T1979 T1978 amod homozygous,allele
R1249 T1980 T1978 amod lethal,allele
R1250 T1981 T1978 punct “,allele
R1251 T1982 T1978 amod null,allele
R1252 T1983 T1978 punct ”,allele
R1253 T1984 T1985 aux to,contribute
R1254 T1985 T1975 acl contribute,potential
R1255 T1986 T1985 advmod nevertheless,contribute
R1256 T1987 T1985 prep to,contribute
R1257 T1988 T1989 amod organismal,phenotype
R1258 T1989 T1987 pobj phenotype,to
R1259 T1990 T1973 punct ", ",combined
R1260 T1991 T1973 nsubj we,combined
R1261 T1992 T1993 det an,allele
R1262 T1993 T1973 dobj allele,combined
R1263 T1994 T1993 compound Xpd†XPCS,allele
R1264 T1995 T1993 prep with,allele
R1265 T1996 T1997 det a,allele
R1266 T1997 T1995 pobj allele,with
R1267 T1998 T1997 amod viable,allele
R1268 T1999 T1997 compound XpdTTD,allele
R1269 T2000 T1973 prep by,combined
R1270 T2001 T2000 pcomp crossing,by
R1271 T2002 T2003 det the,animals
R1272 T2003 T2001 dobj animals,crossing
R1273 T2004 T2003 amod corresponding,animals
R1274 T2005 T2003 amod heterozygous,animals
R1275 T2006 T1973 punct .,combined
R1276 T2008 T2009 advcl Similar,born
R1277 T2010 T2008 prep to,Similar
R1278 T2011 T2012 amod hemizygous,mice
R1279 T2012 T2010 pobj mice,to
R1280 T2013 T2012 compound TTD,mice
R1281 T2014 T2012 acl carrying,mice
R1282 T2015 T2016 nummod one,allele
R1283 T2016 T2014 dobj allele,carrying
R1284 T2017 T2016 amod true,allele
R1285 T2018 T2019 compound Xpd,knockout
R1286 T2019 T2016 compound knockout,allele
R1287 T2020 T2021 punct (,KO
R1288 T2021 T2016 parataxis KO,allele
R1289 T2022 T2021 compound XpdTTD,KO
R1290 T2023 T2021 punct /,KO
R1291 T2024 T2021 punct ),KO
R1292 T2025 T2009 punct ", ",born
R1293 T2026 T2027 nmod compound,mice
R1294 T2027 T2009 nsubjpass mice,born
R1295 T2028 T2027 amod heterozygous,mice
R1296 T2029 T2030 compound XpdTTD,†XPCS
R1297 T2030 T2027 compound †XPCS,mice
R1298 T2031 T2030 punct /,†XPCS
R1299 T2032 T2009 auxpass were,born
R1300 T2033 T2009 prep at,born
R1301 T2034 T2035 det the,frequencies
R1302 T2035 T2033 pobj frequencies,at
R1303 T2036 T2035 amod expected,frequencies
R1304 T2037 T2035 amod Mendelian,frequencies
R1305 T2038 T2009 punct .,born
R1306 T2040 T2041 nsubjpass Expression,reduced
R1307 T2042 T2040 prep from,Expression
R1308 T2043 T2044 det the,allele
R1309 T2044 T2042 pobj allele,from
R1310 T2045 T2044 compound Xpd†XPCS,allele
R1311 T2046 T2041 auxpass was,reduced
R1312 T2047 T2041 advmod also,reduced
R1313 T2048 T2041 prep in,reduced
R1314 T2049 T2050 det the,testis
R1315 T2050 T2048 pobj testis,in
R1316 T2051 T2050 prep of,testis
R1317 T2052 T2053 nmod compound,animals
R1318 T2053 T2051 pobj animals,of
R1319 T2054 T2053 amod heterozygous,animals
R1320 T2055 T2041 punct ", ",reduced
R1321 T2056 T2057 mark whereas,increased
R1322 T2057 T2041 advcl increased,reduced
R1323 T2058 T2057 nsubjpass expression,increased
R1324 T2059 T2058 prep from,expression
R1325 T2060 T2061 det the,allele
R1326 T2061 T2059 pobj allele,from
R1327 T2062 T2061 compound XpdTTD,allele
R1328 T2063 T2057 auxpass was,increased
R1329 T2064 T2057 advcl relative,increased
R1330 T2065 T2064 prep to,relative
R1331 T2066 T2065 pobj wt,to
R1332 T2067 T2057 prep by,increased
R1333 T2068 T2069 punct ~,5-fold
R1334 T2069 T2067 pobj 5-fold,by
R1335 T2070 T2071 punct (,1E
R1336 T2071 T2057 parataxis 1E,increased
R1337 T2072 T2071 compound Figure,1E
R1338 T2073 T2071 punct ),1E
R1339 T2074 T2041 punct .,reduced
R1340 T2076 T2077 prep Because,were
R1341 T2078 T2076 pcomp of,Because
R1342 T2079 T2080 det a,lack
R1343 T2080 T2076 pobj lack,Because
R1344 T2081 T2080 prep of,lack
R1345 T2082 T2083 amod available,antibodies
R1346 T2083 T2081 pobj antibodies,of
R1347 T2084 T2083 cc and,antibodies
R1348 T2085 T2086 det the,inability
R1349 T2086 T2083 conj inability,antibodies
R1350 T2087 T2088 aux to,distinguish
R1351 T2088 T2086 acl distinguish,inability
R1352 T2089 T2088 prep amongst,distinguish
R1353 T2090 T2091 amod various,forms
R1354 T2091 T2089 pobj forms,amongst
R1355 T2092 T2091 amod mutant,forms
R1356 T2093 T2091 prep of,forms
R1357 T2094 T2093 pobj XPD,of
R1358 T2095 T2091 acl differing,forms
R1359 T2096 T2095 advmod only,differing
R1360 T2097 T2095 prep by,differing
R1361 T2098 T2099 amod single,substitutions
R1362 T2099 T2097 pobj substitutions,by
R1363 T2100 T2101 compound amino,acid
R1364 T2101 T2099 compound acid,substitutions
R1365 T2102 T2077 punct ", ",were
R1366 T2103 T2077 nsubj we,were
R1367 T2104 T2077 acomp unable,were
R1368 T2105 T2106 aux to,ascertain
R1369 T2106 T2104 xcomp ascertain,unable
R1370 T2107 T2108 det the,amount
R1371 T2108 T2106 dobj amount,ascertain
R1372 T2109 T2108 amod relative,amount
R1373 T2110 T2108 prep of,amount
R1374 T2111 T2112 compound XPD,protein
R1375 T2112 T2110 pobj protein,of
R1376 T2113 T2112 prep from,protein
R1377 T2114 T2115 det the,alleles
R1378 T2115 T2113 pobj alleles,from
R1379 T2116 T2115 amod different,alleles
R1380 T2117 T2077 punct .,were
R1381 T2119 T2120 prep Despite,ameliorated
R1382 T2121 T2122 amod reduced,levels
R1383 T2122 T2119 pobj levels,Despite
R1384 T2123 T2122 prep of,levels
R1385 T2124 T2125 compound mRNA,expression
R1386 T2125 T2123 pobj expression,of
R1387 T2126 T2120 punct ", ",ameliorated
R1388 T2127 T2128 det the,allele
R1389 T2128 T2120 nsubj allele,ameliorated
R1390 T2129 T2128 amod homozygous,allele
R1391 T2130 T2128 amod lethal,allele
R1392 T2131 T2128 compound Xpd†XPCS,allele
R1393 T2132 T2133 amod multiple,symptoms
R1394 T2133 T2120 dobj symptoms,ameliorated
R1395 T2134 T2135 npadvmod XpdTTD,associated
R1396 T2135 T2133 amod associated,symptoms
R1397 T2136 T2135 punct -,associated
R1398 T2137 T2133 compound disease,symptoms
R1399 T2138 T2120 prep in,ameliorated
R1400 T2139 T2140 amod compound,animals
R1401 T2140 T2138 pobj animals,in
R1402 T2141 T2140 amod heterozygous,animals
R1403 T2142 T2143 compound XpdTTD,†XPCS
R1404 T2143 T2140 compound †XPCS,animals
R1405 T2144 T2143 punct /,†XPCS
R1406 T2145 T2120 prep including,ameliorated
R1407 T2146 T2147 det the,hair
R1408 T2147 T2145 pobj hair,including
R1409 T2148 T2147 nmod hallmark,hair
R1410 T2149 T2147 amod brittle,hair
R1411 T2150 T2147 cc and,hair
R1412 T2151 T2152 amod cutaneous,features
R1413 T2152 T2147 conj features,hair
R1414 T2153 T2154 advmod fully,penetrant
R1415 T2154 T2147 amod penetrant,hair
R1416 T2155 T2154 prep in,penetrant
R1417 T2156 T2157 advmod homo,hemizygous
R1418 T2157 T2160 amod hemizygous,mice
R1419 T2158 T2157 punct -,hemizygous
R1420 T2159 T2157 cc and,hemizygous
R1421 T2160 T2155 pobj mice,in
R1422 T2161 T2160 compound TTD,mice
R1423 T2162 T2163 punct (,2A
R1424 T2163 T2120 parataxis 2A,ameliorated
R1425 T2164 T2163 compound Figure,2A
R1426 T2165 T2166 punct –,2C
R1427 T2166 T2163 prep 2C,2A
R1428 T2167 T2163 punct ),2A
R1429 T2168 T2120 punct .,ameliorated
R1430 T2170 T2171 prep In,displayed
R1431 T2172 T2173 amod marked,contrast
R1432 T2173 T2170 pobj contrast,In
R1433 T2174 T2173 prep to,contrast
R1434 T2175 T2176 nmod XpdTTD,TTD
R1435 T2176 T2178 nmod TTD,mice
R1436 T2177 T2176 punct /,TTD
R1437 T2178 T2174 pobj mice,to
R1438 T2179 T2176 punct (,TTD
R1439 T2180 T2176 cc and,TTD
R1440 T2181 T2182 compound XpdTTD,KO
R1441 T2182 T2176 conj KO,TTD
R1442 T2183 T2182 punct /,KO
R1443 T2184 T2178 punct ),mice
R1444 T2185 T2178 punct ", ",mice
R1445 T2186 T2187 dep which,display
R1446 T2187 T2178 relcl display,mice
R1447 T2188 T2189 amod complete,loss
R1448 T2189 T2187 dobj loss,display
R1449 T2190 T2189 compound hair,loss
R1450 T2191 T2189 prep in,loss
R1451 T2192 T2193 det the,cycle
R1452 T2193 T2191 pobj cycle,in
R1453 T2194 T2193 amod first,cycle
R1454 T2195 T2193 compound hair,cycle
R1455 T2196 T2189 cc and,loss
R1456 T2197 T2198 amod partial,loss
R1457 T2198 T2189 conj loss,loss
R1458 T2199 T2198 compound hair,loss
R1459 T2200 T2198 prep in,loss
R1460 T2201 T2202 amod subsequent,cycles
R1461 T2202 T2200 pobj cycles,in
R1462 T2203 T2187 prep throughout,display
R1463 T2204 T2205 poss their,lives
R1464 T2205 T2203 pobj lives,throughout
R1465 T2206 T2207 punct [,21
R1466 T2207 T2187 parataxis 21,display
R1467 T2208 T2207 punct ],21
R1468 T2209 T2171 punct ", ",displayed
R1469 T2210 T2211 nmod compound,mice
R1470 T2211 T2171 nsubj mice,displayed
R1471 T2212 T2211 amod heterozygous,mice
R1472 T2213 T2211 compound XpdTTD/†XPCS,mice
R1473 T2214 T2215 det some,loss
R1474 T2215 T2171 dobj loss,displayed
R1475 T2216 T2215 compound hair,loss
R1476 T2217 T2218 advmod only,during
R1477 T2218 T2171 prep during,displayed
R1478 T2219 T2220 det the,cycle
R1479 T2220 T2218 pobj cycle,during
R1480 T2221 T2220 amod first,cycle
R1481 T2222 T2220 compound hair,cycle
R1482 T2223 T2218 cc and,during
R1483 T2224 T2225 advmod only,locally
R1484 T2225 T2226 advmod locally,at
R1485 T2226 T2218 conj at,during
R1486 T2227 T2228 det the,back
R1487 T2228 T2226 pobj back,at
R1488 T2229 T2230 punct (,2A
R1489 T2230 T2171 parataxis 2A,displayed
R1490 T2231 T2230 compound Figure,2A
R1491 T2232 T2230 punct ),2A
R1492 T2233 T2171 punct .,displayed
R1493 T2235 T2236 compound Scanning,microscope
R1494 T2236 T2238 compound microscope,analysis
R1495 T2237 T2236 compound electron,microscope
R1496 T2238 T2239 nsubj analysis,revealed
R1497 T2240 T2238 prep of,analysis
R1498 T2241 T2242 compound XpdTTD,†XPCS
R1499 T2242 T2244 compound †XPCS,hair
R1500 T2243 T2242 punct /,†XPCS
R1501 T2244 T2240 pobj hair,of
R1502 T2245 T2246 det an,appearance
R1503 T2246 T2239 dobj appearance,revealed
R1504 T2247 T2248 advmod almost,normal
R1505 T2248 T2246 amod normal,appearance
R1506 T2249 T2246 punct ", ",appearance
R1507 T2250 T2246 prep with,appearance
R1508 T2251 T2252 npadvmod TTD,like
R1509 T2252 T2254 amod like,features
R1510 T2253 T2252 punct -,like
R1511 T2254 T2250 pobj features,with
R1512 T2255 T2256 amod such,as
R1513 T2256 T2254 prep as,features
R1514 T2257 T2258 amod broken,hairs
R1515 T2258 T2256 pobj hairs,as
R1516 T2259 T2254 acl found,features
R1517 T2260 T2261 advmod only,at
R1518 T2261 T2259 prep at,found
R1519 T2262 T2263 advmod very,low
R1520 T2263 T2264 amod low,frequency
R1521 T2264 T2261 pobj frequency,at
R1522 T2265 T2266 punct (,data
R1523 T2266 T2239 parataxis data,revealed
R1524 T2267 T2266 amod unpublished,data
R1525 T2268 T2266 punct ),data
R1526 T2269 T2239 punct .,revealed
R1527 T2271 T2272 compound Amino,acid
R1528 T2272 T2273 compound acid,analysis
R1529 T2273 T2274 nsubj analysis,confirmed
R1530 T2275 T2276 mark that,were
R1531 T2276 T2274 ccomp were,confirmed
R1532 T2277 T2278 compound cysteine,levels
R1533 T2278 T2276 nsubj levels,were
R1534 T2279 T2278 prep in,levels
R1535 T2280 T2281 det the,hair
R1536 T2281 T2279 pobj hair,in
R1537 T2282 T2281 prep of,hair
R1538 T2283 T2284 det the,mice
R1539 T2284 T2282 pobj mice,of
R1540 T2285 T2286 compound XpdTTD,†XPCS
R1541 T2286 T2284 compound †XPCS,mice
R1542 T2287 T2286 punct /,†XPCS
R1543 T2288 T2289 advmod significantly,higher
R1544 T2289 T2276 acomp higher,were
R1545 T2290 T2289 prep than,higher
R1546 T2291 T2290 prep in,than
R1547 T2292 T2293 compound XpdTTD,TTD
R1548 T2293 T2295 compound TTD,animals
R1549 T2294 T2293 punct /,TTD
R1550 T2295 T2291 pobj animals,in
R1551 T2296 T2276 punct ", ",were
R1552 T2297 T2276 cc but,were
R1553 T2298 T2276 conj remained,were
R1554 T2299 T2298 prep below,remained
R1555 T2300 T2301 det the,level
R1556 T2301 T2299 pobj level,below
R1557 T2302 T2301 compound wt,level
R1558 T2303 T2304 punct (,2C
R1559 T2304 T2274 parataxis 2C,confirmed
R1560 T2305 T2304 compound Figure,2C
R1561 T2306 T2304 punct ),2C
R1562 T2307 T2274 punct .,confirmed
R1563 T2309 T2310 compound TTD,hemizygotes
R1564 T2310 T2311 nsubj hemizygotes,display
R1565 T2312 T2313 punct (,KO
R1566 T2313 T2310 parataxis KO,hemizygotes
R1567 T2314 T2313 compound XpdTTD,KO
R1568 T2315 T2313 punct /,KO
R1569 T2316 T2313 punct ),KO
R1570 T2317 T2311 aux do,display
R1571 T2318 T2311 neg not,display
R1572 T2319 T2320 amod significant,differences
R1573 T2320 T2311 dobj differences,display
R1574 T2321 T2320 prep in,differences
R1575 T2322 T2323 amod cutaneous,features
R1576 T2323 T2321 pobj features,in
R1577 T2324 T2323 cc and,features
R1578 T2325 T2323 conj longevity,features
R1579 T2326 T2320 amod relative,differences
R1580 T2327 T2326 prep to,relative
R1581 T2328 T2329 amod homozygous,mice
R1582 T2329 T2327 pobj mice,to
R1583 T2330 T2331 compound XpdTTD,TTD
R1584 T2331 T2329 compound TTD,mice
R1585 T2332 T2331 punct /,TTD
R1586 T2333 T2334 punct [,21
R1587 T2334 T2311 parataxis 21,display
R1588 T2335 T2334 punct ],21
R1589 T2336 T2311 punct .,display
R1590 T2338 T2339 amod Other,features
R1591 T2339 T2342 nsubj features,were
R1592 T2340 T2339 amod prominent,features
R1593 T2341 T2339 compound TTD,features
R1594 T2343 T2339 prep in,features
R1595 T2344 T2345 det the,epidermis
R1596 T2345 T2343 pobj epidermis,in
R1597 T2346 T2339 punct ", ",features
R1598 T2347 T2339 prep including,features
R1599 T2348 T2347 pobj acanthosis,including
R1600 T2349 T2350 punct (,thickening
R1601 T2350 T2348 parataxis thickening,acanthosis
R1602 T2351 T2350 prep of,thickening
R1603 T2352 T2353 det the,layer
R1604 T2353 T2351 pobj layer,of
R1605 T2354 T2353 prep of,layer
R1606 T2355 T2356 det the,cells
R1607 T2356 T2354 pobj cells,of
R1608 T2357 T2356 amod nucleated,cells
R1609 T2358 T2350 punct ),thickening
R1610 T2359 T2348 punct ", ",acanthosis
R1611 T2360 T2348 conj hyperkeratosis,acanthosis
R1612 T2361 T2362 punct (,thickening
R1613 T2362 T2360 parataxis thickening,hyperkeratosis
R1614 T2363 T2362 amod prominent,thickening
R1615 T2364 T2362 prep of,thickening
R1616 T2365 T2366 det the,layer
R1617 T2366 T2364 pobj layer,of
R1618 T2367 T2366 amod cornified,layer
R1619 T2368 T2362 punct ),thickening
R1620 T2369 T2360 punct ", ",hyperkeratosis
R1621 T2370 T2360 cc and,hyperkeratosis
R1622 T2371 T2372 amod pronounced,layer
R1623 T2372 T2360 conj layer,hyperkeratosis
R1624 T2373 T2372 amod granular,layer
R1625 T2374 T2372 cc and,layer
R1626 T2375 T2376 amod sebacious,gland
R1627 T2376 T2377 compound gland,hyperplasia
R1628 T2377 T2372 conj hyperplasia,layer
R1629 T2378 T2379 punct (,causing
R1630 T2379 T2377 parataxis causing,hyperplasia
R1631 T2380 T2381 amod greasy,appearance
R1632 T2381 T2379 dobj appearance,causing
R1633 T2382 T2381 prep of,appearance
R1634 T2383 T2384 det the,hair
R1635 T2384 T2382 pobj hair,of
R1636 T2385 T2379 punct ),causing
R1637 T2386 T2342 punct ", ",were
R1638 T2387 T2342 acomp absent,were
R1639 T2388 T2342 prep in,were
R1640 T2389 T2390 det the,skin
R1641 T2390 T2388 pobj skin,in
R1642 T2391 T2390 prep of,skin
R1643 T2392 T2393 compound XpdTTD,†XPCS
R1644 T2393 T2395 compound †XPCS,mice
R1645 T2394 T2393 punct /,†XPCS
R1646 T2395 T2391 pobj mice,of
R1647 T2396 T2342 punct ", ",were
R1648 T2397 T2398 mark as,established
R1649 T2398 T2342 advcl established,were
R1650 T2399 T2398 prep by,established
R1651 T2400 T2401 amod blind,examination
R1652 T2401 T2399 pobj examination,by
R1653 T2402 T2401 amod microscopic,examination
R1654 T2403 T2401 prep of,examination
R1655 T2404 T2405 compound skin,sections
R1656 T2405 T2403 pobj sections,of
R1657 T2406 T2407 punct (,2B
R1658 T2407 T2342 parataxis 2B,were
R1659 T2408 T2407 compound Figure,2B
R1660 T2409 T2407 punct ),2B
R1661 T2410 T2342 punct .,were
R1662 T2412 T2413 advmod Furthermore,rescued
R1663 T2414 T2413 punct ", ",rescued
R1664 T2415 T2413 nsubjpass anaemia,rescued
R1665 T2416 T2415 cc and,anaemia
R1666 T2417 T2418 amod developmental,delay
R1667 T2418 T2415 conj delay,anaemia
R1668 T2419 T2415 amod present,anaemia
R1669 T2420 T2419 prep in,present
R1670 T2421 T2420 pobj patients,in
R1671 T2422 T2421 prep with,patients
R1672 T2423 T2422 pobj TTD,with
R1673 T2424 T2425 punct [,24
R1674 T2425 T2421 parataxis 24,patients
R1675 T2426 T2425 punct ],24
R1676 T2427 T2420 cc and,in
R1677 T2428 T2420 conj in,in
R1678 T2429 T2430 compound XpdTTD,TTD
R1679 T2430 T2432 compound TTD,mice
R1680 T2431 T2430 punct /,TTD
R1681 T2432 T2428 pobj mice,in
R1682 T2433 T2434 punct [,15
R1683 T2434 T2432 parataxis 15,mice
R1684 T2435 T2434 punct ],15
R1685 T2436 T2413 auxpass were,rescued
R1686 T2437 T2413 advmod both,rescued
R1687 T2438 T2413 advmod partially,rescued
R1688 T2439 T2413 prep in,rescued
R1689 T2440 T2441 amod compound,mice
R1690 T2441 T2439 pobj mice,in
R1691 T2442 T2441 amod heterozygous,mice
R1692 T2443 T2444 compound XpdTTD,†XPCS
R1693 T2444 T2441 compound †XPCS,mice
R1694 T2445 T2444 punct /,†XPCS
R1695 T2446 T2447 punct (,2D
R1696 T2447 T2413 parataxis 2D,rescued
R1697 T2448 T2447 compound Figure,2D
R1698 T2449 T2447 cc and,2D
R1699 T2450 T2447 conj 2E,2D
R1700 T2451 T2447 punct ),2D
R1701 T2452 T2413 punct .,rescued
R5176 T7658 T7659 amod Partial,Rescue
R5177 T7660 T7659 prep of,Rescue
R5178 T7661 T7660 pobj TTD,of
R5179 T7662 T7661 amod Cutaneous,TTD
R5180 T7663 T7661 punct ", ",TTD
R5181 T7664 T7661 conj Blood,TTD
R5182 T7665 T7664 punct ", ",Blood
R5183 T7666 T7664 cc and,Blood
R5184 T7667 T7668 amod Developmental,Phenotypes
R5185 T7668 T7664 conj Phenotypes,Blood
R5186 T7669 T7659 prep in,Rescue
R5187 T7670 T7671 nmod Compound,Mice
R5188 T7671 T7669 pobj Mice,in
R5189 T7672 T7671 amod Heterozygous,Mice
R5190 T7673 T7674 compound XpdTTD,†XPCS
R5191 T7674 T7671 compound †XPCS,Mice
R5192 T7675 T7674 punct /,†XPCS
R5193 T7677 T7678 punct (,A
R5194 T7678 T7679 meta A,Photographs
R5195 T7680 T7678 punct ),A
R5196 T7681 T7679 prep of,Photographs
R5197 T7682 T7683 nummod 5,mo
R5198 T7683 T7685 npadvmod mo,old
R5199 T7684 T7683 punct -,mo
R5200 T7685 T7687 amod old,mice
R5201 T7686 T7685 punct -,old
R5202 T7687 T7681 pobj mice,of
R5203 T7688 T7689 amod homozygous,TTD
R5204 T7689 T7687 nmod TTD,mice
R5205 T7690 T7689 nmod XpdTTD,TTD
R5206 T7691 T7689 punct /,TTD
R5207 T7692 T7689 punct ", ",TTD
R5208 T7693 T7694 nmod compound,†XPCS
R5209 T7694 T7689 conj †XPCS,TTD
R5210 T7695 T7694 amod heterozygous,†XPCS
R5211 T7696 T7694 compound XpdTTD,†XPCS
R5212 T7697 T7694 punct /,†XPCS
R5213 T7698 T7694 punct ", ",†XPCS
R5214 T7699 T7694 cc and,†XPCS
R5215 T7700 T7694 conj wt,†XPCS
R5216 T7701 T7679 punct .,Photographs
R5217 T7704 T7703 punct : ,Insets
R5218 T7705 T7703 appos images,Insets
R5219 T7706 T7705 prep of,images
R5220 T7707 T7708 amod first,round
R5221 T7708 T7710 compound round,loss
R5222 T7709 T7708 punct -,round
R5223 T7710 T7706 pobj loss,of
R5224 T7711 T7710 compound hair,loss
R5225 T7712 T7703 punct .,Insets
R5226 T7714 T7715 punct (,B
R5227 T7715 T7716 meta B,analysis
R5228 T7717 T7715 punct ),B
R5229 T7718 T7716 amod Histological,analysis
R5230 T7719 T7716 prep of,analysis
R5231 T7720 T7721 det the,skin
R5232 T7721 T7719 pobj skin,of
R5233 T7722 T7721 prep of,skin
R5234 T7723 T7724 nmod XpdTTD,TTD
R5235 T7724 T7726 nmod TTD,mice
R5236 T7725 T7724 punct /,TTD
R5237 T7726 T7722 pobj mice,of
R5238 T7727 T7724 punct ", ",TTD
R5239 T7728 T7729 compound XpdTTD,†XPCS
R5240 T7729 T7724 conj †XPCS,TTD
R5241 T7730 T7729 punct /,†XPCS
R5242 T7731 T7729 punct ", ",†XPCS
R5243 T7732 T7729 cc and,†XPCS
R5244 T7733 T7729 conj wt,†XPCS
R5245 T7734 T7716 punct .,analysis
R5246 T7736 T7737 npadvmod TTD,associated
R5247 T7737 T7739 amod associated,acanthosis
R5248 T7738 T7737 punct -,associated
R5249 T7739 T7740 nsubj acanthosis,were
R5250 T7741 T7742 punct (,epidermis
R5251 T7742 T7739 parataxis epidermis,acanthosis
R5252 T7743 T7742 amod thicker,epidermis
R5253 T7744 T7742 punct ", ",epidermis
R5254 T7745 T7742 acl indicated,epidermis
R5255 T7746 T7745 agent by,indicated
R5256 T7747 T7748 amod solid,line
R5257 T7748 T7746 pobj line,by
R5258 T7749 T7748 amod vertical,line
R5259 T7750 T7742 punct ),epidermis
R5260 T7751 T7739 punct ", ",acanthosis
R5261 T7752 T7753 amod pronounced,layer
R5262 T7753 T7739 conj layer,acanthosis
R5263 T7754 T7753 amod granular,layer
R5264 T7755 T7753 punct (,layer
R5265 T7756 T7753 acl indicated,layer
R5266 T7757 T7756 agent by,indicated
R5267 T7758 T7757 pobj arrows,by
R5268 T7759 T7753 punct ),layer
R5269 T7760 T7753 punct ", ",layer
R5270 T7761 T7753 cc and,layer
R5271 T7762 T7763 amod sebacious,hyperplasia
R5272 T7763 T7753 conj hyperplasia,layer
R5273 T7764 T7763 compound gland,hyperplasia
R5274 T7765 T7763 punct (,hyperplasia
R5275 T7766 T7763 acl indicated,hyperplasia
R5276 T7767 T7766 agent by,indicated
R5277 T7768 T7769 amod dotted,line
R5278 T7769 T7767 pobj line,by
R5279 T7770 T7769 amod vertical,line
R5280 T7771 T7740 punct ),were
R5281 T7772 T7740 acomp absent,were
R5282 T7773 T7740 prep in,were
R5283 T7774 T7775 det the,epidermis
R5284 T7775 T7773 pobj epidermis,in
R5285 T7776 T7775 prep of,epidermis
R5286 T7777 T7778 nmod XpdTTD,†XPCS
R5287 T7778 T7780 nmod †XPCS,mice
R5288 T7779 T7778 punct /,†XPCS
R5289 T7780 T7776 pobj mice,of
R5290 T7781 T7778 cc and,†XPCS
R5291 T7782 T7778 conj wt,†XPCS
R5292 T7783 T7740 punct .,were
R5293 T7786 T7785 appos 400,Magnification
R5294 T7787 T7786 punct ×,400
R5295 T7788 T7785 punct .,Magnification
R5296 T7790 T7791 punct (,C
R5297 T7791 T7792 meta C,content
R5298 T7793 T7791 punct ),C
R5299 T7794 T7792 compound Cysteine,content
R5300 T7795 T7792 prep of,content
R5301 T7796 T7795 pobj hair,of
R5302 T7797 T7796 prep from,hair
R5303 T7798 T7799 nmod wt,mice
R5304 T7799 T7797 pobj mice,from
R5305 T7800 T7798 punct ", ",wt
R5306 T7801 T7802 compound XpdTTD,TTD
R5307 T7802 T7798 conj TTD,wt
R5308 T7803 T7802 punct /,TTD
R5309 T7804 T7802 punct ", ",TTD
R5310 T7805 T7802 cc and,TTD
R5311 T7806 T7807 compound XpdTTD,†XPCS
R5312 T7807 T7802 conj †XPCS,TTD
R5313 T7808 T7807 punct /,†XPCS
R5314 T7809 T7792 punct .,content
R5315 T7811 T7812 det The,value
R5316 T7812 T7815 nsubj value,indicates
R5317 T7813 T7812 compound p,value
R5318 T7814 T7812 punct -,value
R5319 T7816 T7817 amod significant,differences
R5320 T7817 T7815 dobj differences,indicates
R5321 T7818 T7817 prep between,differences
R5322 T7819 T7818 pobj mutants,between
R5323 T7820 T7819 cc and,mutants
R5324 T7821 T7819 conj wt,mutants
R5325 T7822 T7818 punct ", ",between
R5326 T7823 T7824 advmod as,as
R5327 T7824 T7818 cc as,between
R5328 T7825 T7824 advmod well,as
R5329 T7826 T7818 conj between,between
R5330 T7827 T7828 nmod XpdTTD,TTD
R5331 T7828 T7830 nmod TTD,mice
R5332 T7829 T7828 punct /,TTD
R5333 T7830 T7826 pobj mice,between
R5334 T7831 T7828 cc and,TTD
R5335 T7832 T7833 compound XpdTTD,†XPCS
R5336 T7833 T7828 conj †XPCS,TTD
R5337 T7834 T7833 punct /,†XPCS
R5338 T7835 T7815 punct .,indicates
R5339 T7837 T7838 compound Error,bars
R5340 T7838 T7839 nsubj bars,indicate
R5341 T7840 T7841 amod standard,error
R5342 T7841 T7839 dobj error,indicate
R5343 T7842 T7841 prep of,error
R5344 T7843 T7844 det the,mean
R5345 T7844 T7842 pobj mean,of
R5346 T7845 T7841 punct (,error
R5347 T7846 T7841 appos SEM,error
R5348 T7847 T7839 punct ),indicate
R5349 T7848 T7839 punct .,indicate
R5350 T7850 T7851 punct (,D
R5351 T7851 T7852 meta D,values
R5352 T7853 T7851 punct ),D
R5353 T7854 T7852 compound Hematocrit,values
R5354 T7855 T7852 prep from,values
R5355 T7856 T7855 pobj blood,from
R5356 T7857 T7856 prep of,blood
R5357 T7858 T7859 nmod XpdTTD,TTD
R5358 T7859 T7861 nmod TTD,mice
R5359 T7860 T7859 punct /,TTD
R5360 T7861 T7857 pobj mice,of
R5361 T7862 T7859 cc and,TTD
R5362 T7863 T7864 compound XpdTTD,†XPCS
R5363 T7864 T7859 conj †XPCS,TTD
R5364 T7865 T7864 punct /,†XPCS
R5365 T7866 T7852 punct .,values
R5366 T7868 T7869 det The,values
R5367 T7869 T7872 nsubj values,indicate
R5368 T7870 T7869 compound p,values
R5369 T7871 T7869 punct -,values
R5370 T7873 T7874 det the,significance
R5371 T7874 T7872 dobj significance,indicate
R5372 T7875 T7874 prep of,significance
R5373 T7876 T7877 det the,difference
R5374 T7877 T7875 pobj difference,of
R5375 T7878 T7872 advcl relative,indicate
R5376 T7879 T7878 prep to,relative
R5377 T7880 T7879 pobj wt,to
R5378 T7881 T7872 punct .,indicate
R5379 T7883 T7884 compound Error,bars
R5380 T7884 T7885 nsubj bars,indicate
R5381 T7886 T7885 dobj SEM,indicate
R5382 T7887 T7885 punct .,indicate
R5383 T7889 T7890 punct (,E
R5384 T7890 T7891 meta E,weights
R5385 T7892 T7890 punct ),E
R5386 T7893 T7891 compound Body,weights
R5387 T7894 T7891 prep of,weights
R5388 T7895 T7896 amod developing,mice
R5389 T7896 T7894 pobj mice,of
R5390 T7897 T7898 nmod XpdTTD,TTD
R5391 T7898 T7896 nmod TTD,mice
R5392 T7899 T7898 punct /,TTD
R5393 T7900 T7898 cc and,TTD
R5394 T7901 T7902 compound XpdTTD,†XPCS
R5395 T7902 T7898 conj †XPCS,TTD
R5396 T7903 T7902 punct /,†XPCS
R5397 T7904 T7896 prep after,mice
R5398 T7905 T7904 pobj weaning,after
R5399 T7906 T7891 acl plotted,weights
R5400 T7907 T7906 prep as,plotted
R5401 T7908 T7909 det a,percentage
R5402 T7909 T7907 pobj percentage,as
R5403 T7910 T7909 prep of,percentage
R5404 T7911 T7912 det the,weight
R5405 T7912 T7910 pobj weight,of
R5406 T7913 T7912 prep of,weight
R5407 T7914 T7915 npadvmod age,matched
R5408 T7915 T7917 amod matched,littermates
R5409 T7916 T7915 punct -,matched
R5410 T7917 T7913 pobj littermates,of
R5411 T7918 T7917 nmod control,littermates
R5412 T7919 T7917 nmod wt,littermates
R5413 T7920 T7919 cc and,wt
R5414 T7921 T7919 conj heterozygote,wt
R5415 T7922 T7923 punct (,hz
R5416 T7923 T7921 parataxis hz,heterozygote
R5417 T7924 T7923 punct ),hz
R5418 T7925 T7926 punct (,set
R5419 T7926 T7909 parataxis set,percentage
R5420 T7927 T7926 prep at,set
R5421 T7928 T7929 nummod 100,%
R5422 T7929 T7927 pobj %,at
R5423 T7930 T7926 punct ),set
R5424 T7931 T7891 punct .,weights
R5425 T7933 T7934 compound Error,bars
R5426 T7934 T7935 nsubj bars,indicate
R5427 T7936 T7935 dobj SEM,indicate
R5428 T7937 T7935 punct .,indicate