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PMC:1584416 / 34031-35050 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6372 0-10 NN denotes Generation
T6374 11-13 IN denotes of
T6375 14-20 NN denotes XpdTTD
T6377 21-22 -LRB- denotes (
T6378 22-30 NN denotes XPDR722W
T6379 30-31 -RRB- denotes )
T6380 32-35 CC denotes and
T6381 36-42 NN denotes XpdTTD
T6383 42-43 HYPH denotes /
T6382 43-45 NN denotes KO
T6376 46-50 NNS denotes mice
T6384 51-54 VBZ denotes has
T6385 55-59 VBN denotes been
T6373 60-69 VBN denotes described
T6386 70-80 RB denotes previously
T6387 81-82 -LRB- denotes [
T6389 82-84 CD denotes 21
T6390 84-85 , denotes ,
T6388 85-87 CD denotes 22
T6391 87-88 -RRB- denotes ]
T6392 88-89 . denotes .
T6393 89-278 sentence denotes A detailed description of the generation of targeting constructs for Xpd†XPCS and Xpd †XP alleles carrying mutations encoding the G602D and R683W alterations will be provided upon request.
T6394 90-91 DT denotes A
T6396 92-100 JJ denotes detailed
T6395 101-112 NN denotes description
T6398 113-115 IN denotes of
T6399 116-119 DT denotes the
T6400 120-130 NN denotes generation
T6401 131-133 IN denotes of
T6402 134-143 VBG denotes targeting
T6403 144-154 NNS denotes constructs
T6404 155-158 IN denotes for
T6405 159-167 NN denotes Xpd†XPCS
T6407 168-171 CC denotes and
T6408 172-179 NN denotes Xpd †XP
T6406 180-187 NNS denotes alleles
T6409 188-196 VBG denotes carrying
T6410 197-206 NNS denotes mutations
T6411 207-215 VBG denotes encoding
T6412 216-219 DT denotes the
T6414 220-225 NN denotes G602D
T6415 226-229 CC denotes and
T6416 230-235 NN denotes R683W
T6413 236-247 NNS denotes alterations
T6417 248-252 MD denotes will
T6418 253-255 VB denotes be
T6397 256-264 VBN denotes provided
T6419 265-269 IN denotes upon
T6420 270-277 NN denotes request
T6421 277-278 . denotes .
T6422 278-373 sentence denotes Chimeric mice and mouse embryonic fibroblasts were generated according to standard procedures.
T6423 279-287 JJ denotes Chimeric
T6425 288-292 NNS denotes mice
T6426 293-296 CC denotes and
T6427 297-302 NN denotes mouse
T6428 303-312 JJ denotes embryonic
T6424 313-324 NNS denotes fibroblasts
T6430 325-329 VBD denotes were
T6429 330-339 VBN denotes generated
T6431 340-349 VBG denotes according
T6432 350-352 IN denotes to
T6433 353-361 JJ denotes standard
T6434 362-372 NNS denotes procedures
T6435 372-373 . denotes .
T6436 373-453 sentence denotes Haematoxylin and eosin staining was performed according to standard procedures.
T6437 374-386 NN denotes Haematoxylin
T6439 387-390 CC denotes and
T6440 391-396 NN denotes eosin
T6438 397-405 NN denotes staining
T6442 406-409 VBD denotes was
T6441 410-419 VBN denotes performed
T6443 420-429 VBG denotes according
T6444 430-432 IN denotes to
T6445 433-441 JJ denotes standard
T6446 442-452 NNS denotes procedures
T6447 452-453 . denotes .
T6448 453-509 sentence denotes Amino acid analysis was conducted as described in [21].
T6449 454-459 NN denotes Amino
T6450 460-464 NN denotes acid
T6451 465-473 NN denotes analysis
T6453 474-477 VBD denotes was
T6452 478-487 VBN denotes conducted
T6454 488-490 IN denotes as
T6455 491-500 VBN denotes described
T6456 501-503 IN denotes in
T6457 504-505 -LRB- denotes [
T6458 505-507 CD denotes 21
T6459 507-508 -RRB- denotes ]
T6460 508-509 . denotes .
T6461 509-606 sentence denotes Blood values were analysed using Animal Blood Counter Vet (ABX Diagnostix, Montpellier, France).
T6462 510-515 NN denotes Blood
T6463 516-522 NNS denotes values
T6465 523-527 VBD denotes were
T6464 528-536 VBN denotes analysed
T6466 537-542 VBG denotes using
T6467 543-549 NN denotes Animal
T6469 550-555 NN denotes Blood
T6470 556-563 JJ denotes Counter
T6468 564-567 NN denotes Vet
T6471 568-569 -LRB- denotes (
T6473 569-572 NNP denotes ABX
T6472 573-583 NNP denotes Diagnostix
T6474 583-585 , denotes ,
T6475 585-596 NNP denotes Montpellier
T6476 596-598 , denotes ,
T6477 598-604 NNP denotes France
T6478 604-605 -RRB- denotes )
T6479 605-606 . denotes .
T6480 606-701 sentence denotes Radiographs were taken, and relative bone mineral density was calculated as described in [15].
T6481 607-618 NNS denotes Radiographs
T6483 619-623 VBD denotes were
T6482 624-629 VBN denotes taken
T6484 629-631 , denotes ,
T6485 631-634 CC denotes and
T6486 635-643 JJ denotes relative
T6488 644-648 NN denotes bone
T6489 649-656 NN denotes mineral
T6487 657-664 NN denotes density
T6491 665-668 VBD denotes was
T6490 669-679 VBN denotes calculated
T6492 680-682 IN denotes as
T6493 683-692 VBN denotes described
T6494 693-695 IN denotes in
T6495 696-697 -LRB- denotes [
T6496 697-699 CD denotes 15
T6497 699-700 -RRB- denotes ]
T6498 700-701 . denotes .
T6499 701-792 sentence denotes Mice used in this study were in a 129Ola/C57BL6 mixed background unless noted differently.
T6500 702-706 NNS denotes Mice
T6502 707-711 VBN denotes used
T6503 712-714 IN denotes in
T6504 715-719 DT denotes this
T6505 720-725 NN denotes study
T6501 726-730 VBD denotes were
T6506 731-733 IN denotes in
T6507 734-735 DT denotes a
T6509 736-742 NN denotes 129Ola
T6511 742-743 HYPH denotes /
T6510 743-749 NN denotes C57BL6
T6512 750-755 JJ denotes mixed
T6508 756-766 NN denotes background
T6513 767-773 IN denotes unless
T6514 774-779 VBN denotes noted
T6515 780-791 RB denotes differently
T6516 791-792 . denotes .
T6517 792-1019 sentence denotes All experiments involving mice were judged and approved by the national committee for genetic identification of organisms and the animal ethical committee, and were conducted according to national and international guidelines.
T6518 793-796 DT denotes All
T6519 797-808 NNS denotes experiments
T6521 809-818 VBG denotes involving
T6522 819-823 NNS denotes mice
T6523 824-828 VBD denotes were
T6520 829-835 VBN denotes judged
T6524 836-839 CC denotes and
T6525 840-848 VBN denotes approved
T6526 849-851 IN denotes by
T6527 852-855 DT denotes the
T6529 856-864 JJ denotes national
T6528 865-874 NN denotes committee
T6530 875-878 IN denotes for
T6531 879-886 JJ denotes genetic
T6532 887-901 NN denotes identification
T6533 902-904 IN denotes of
T6534 905-914 NNS denotes organisms
T6535 915-918 CC denotes and
T6536 919-922 DT denotes the
T6538 923-929 NN denotes animal
T6539 930-937 JJ denotes ethical
T6537 938-947 NN denotes committee
T6540 947-949 , denotes ,
T6541 949-952 CC denotes and
T6542 953-957 VBD denotes were
T6543 958-967 VBN denotes conducted
T6544 968-977 VBG denotes according
T6545 978-980 IN denotes to
T6546 981-989 JJ denotes national
T6548 990-993 CC denotes and
T6549 994-1007 JJ denotes international
T6547 1008-1018 NNS denotes guidelines
T6550 1018-1019 . denotes .
R4341 T6372 T6373 nsubjpass Generation,described
R4342 T6374 T6372 prep of,Generation
R4343 T6375 T6376 nmod XpdTTD,mice
R4344 T6376 T6374 pobj mice,of
R4345 T6377 T6378 punct (,XPDR722W
R4346 T6378 T6375 parataxis XPDR722W,XpdTTD
R4347 T6379 T6378 punct ),XPDR722W
R4348 T6380 T6375 cc and,XpdTTD
R4349 T6381 T6382 compound XpdTTD,KO
R4350 T6382 T6375 conj KO,XpdTTD
R4351 T6383 T6382 punct /,KO
R4352 T6384 T6373 aux has,described
R4353 T6385 T6373 auxpass been,described
R4354 T6386 T6373 advmod previously,described
R4355 T6387 T6388 punct [,22
R4356 T6388 T6373 parataxis 22,described
R4357 T6389 T6388 nummod 21,22
R4358 T6390 T6388 punct ",",22
R4359 T6391 T6388 punct ],22
R4360 T6392 T6373 punct .,described
R4361 T6394 T6395 det A,description
R4362 T6395 T6397 nsubjpass description,provided
R4363 T6396 T6395 amod detailed,description
R4364 T6398 T6395 prep of,description
R4365 T6399 T6400 det the,generation
R4366 T6400 T6398 pobj generation,of
R4367 T6401 T6400 prep of,generation
R4368 T6402 T6403 amod targeting,constructs
R4369 T6403 T6401 pobj constructs,of
R4370 T6404 T6403 prep for,constructs
R4371 T6405 T6406 nmod Xpd†XPCS,alleles
R4372 T6406 T6404 pobj alleles,for
R4373 T6407 T6405 cc and,Xpd†XPCS
R4374 T6408 T6405 conj Xpd †XP,Xpd†XPCS
R4375 T6409 T6406 acl carrying,alleles
R4376 T6410 T6409 dobj mutations,carrying
R4377 T6411 T6410 acl encoding,mutations
R4378 T6412 T6413 det the,alterations
R4379 T6413 T6411 dobj alterations,encoding
R4380 T6414 T6413 nmod G602D,alterations
R4381 T6415 T6414 cc and,G602D
R4382 T6416 T6414 conj R683W,G602D
R4383 T6417 T6397 aux will,provided
R4384 T6418 T6397 auxpass be,provided
R4385 T6419 T6397 prep upon,provided
R4386 T6420 T6419 pobj request,upon
R4387 T6421 T6397 punct .,provided
R4388 T6423 T6424 amod Chimeric,fibroblasts
R4389 T6424 T6429 nsubjpass fibroblasts,generated
R4390 T6425 T6424 nmod mice,fibroblasts
R4391 T6426 T6425 cc and,mice
R4392 T6427 T6428 npadvmod mouse,embryonic
R4393 T6428 T6425 conj embryonic,mice
R4394 T6430 T6429 auxpass were,generated
R4395 T6431 T6429 prep according,generated
R4396 T6432 T6431 prep to,according
R4397 T6433 T6434 amod standard,procedures
R4398 T6434 T6432 pobj procedures,to
R4399 T6435 T6429 punct .,generated
R4400 T6437 T6438 nmod Haematoxylin,staining
R4401 T6438 T6441 nsubjpass staining,performed
R4402 T6439 T6437 cc and,Haematoxylin
R4403 T6440 T6437 conj eosin,Haematoxylin
R4404 T6442 T6441 auxpass was,performed
R4405 T6443 T6441 prep according,performed
R4406 T6444 T6443 prep to,according
R4407 T6445 T6446 amod standard,procedures
R4408 T6446 T6444 pobj procedures,to
R4409 T6447 T6441 punct .,performed
R4410 T6449 T6450 compound Amino,acid
R4411 T6450 T6451 compound acid,analysis
R4412 T6451 T6452 nsubjpass analysis,conducted
R4413 T6453 T6452 auxpass was,conducted
R4414 T6454 T6455 mark as,described
R4415 T6455 T6452 advcl described,conducted
R4416 T6456 T6455 prep in,described
R4417 T6457 T6456 punct [,in
R4418 T6458 T6456 pobj 21,in
R4419 T6459 T6452 punct ],conducted
R4420 T6460 T6452 punct .,conducted
R4421 T6462 T6463 compound Blood,values
R4422 T6463 T6464 nsubjpass values,analysed
R4423 T6465 T6464 auxpass were,analysed
R4424 T6466 T6464 advcl using,analysed
R4425 T6467 T6468 nmod Animal,Vet
R4426 T6468 T6466 dobj Vet,using
R4427 T6469 T6468 nmod Blood,Vet
R4428 T6470 T6468 amod Counter,Vet
R4429 T6471 T6472 punct (,Diagnostix
R4430 T6472 T6468 parataxis Diagnostix,Vet
R4431 T6473 T6472 compound ABX,Diagnostix
R4432 T6474 T6472 punct ", ",Diagnostix
R4433 T6475 T6472 npadvmod Montpellier,Diagnostix
R4434 T6476 T6472 punct ", ",Diagnostix
R4435 T6477 T6472 npadvmod France,Diagnostix
R4436 T6478 T6472 punct ),Diagnostix
R4437 T6479 T6464 punct .,analysed
R4438 T6481 T6482 nsubjpass Radiographs,taken
R4439 T6483 T6482 auxpass were,taken
R4440 T6484 T6482 punct ", ",taken
R4441 T6485 T6482 cc and,taken
R4442 T6486 T6487 amod relative,density
R4443 T6487 T6490 nsubjpass density,calculated
R4444 T6488 T6489 compound bone,mineral
R4445 T6489 T6487 compound mineral,density
R4446 T6490 T6482 conj calculated,taken
R4447 T6491 T6490 auxpass was,calculated
R4448 T6492 T6493 mark as,described
R4449 T6493 T6490 advcl described,calculated
R4450 T6494 T6493 prep in,described
R4451 T6495 T6494 punct [,in
R4452 T6496 T6494 pobj 15,in
R4453 T6497 T6490 punct ],calculated
R4454 T6498 T6490 punct .,calculated
R4455 T6500 T6501 nsubj Mice,were
R4456 T6502 T6500 acl used,Mice
R4457 T6503 T6502 prep in,used
R4458 T6504 T6505 det this,study
R4459 T6505 T6503 pobj study,in
R4460 T6506 T6501 prep in,were
R4461 T6507 T6508 det a,background
R4462 T6508 T6506 pobj background,in
R4463 T6509 T6510 nmod 129Ola,C57BL6
R4464 T6510 T6508 nmod C57BL6,background
R4465 T6511 T6510 punct /,C57BL6
R4466 T6512 T6508 amod mixed,background
R4467 T6513 T6514 mark unless,noted
R4468 T6514 T6501 advcl noted,were
R4469 T6515 T6514 advmod differently,noted
R4470 T6516 T6501 punct .,were
R4471 T6518 T6519 det All,experiments
R4472 T6519 T6520 nsubjpass experiments,judged
R4473 T6521 T6519 acl involving,experiments
R4474 T6522 T6521 dobj mice,involving
R4475 T6523 T6520 auxpass were,judged
R4476 T6524 T6520 cc and,judged
R4477 T6525 T6520 conj approved,judged
R4478 T6526 T6525 agent by,approved
R4479 T6527 T6528 det the,committee
R4480 T6528 T6526 pobj committee,by
R4481 T6529 T6528 amod national,committee
R4482 T6530 T6528 prep for,committee
R4483 T6531 T6532 amod genetic,identification
R4484 T6532 T6530 pobj identification,for
R4485 T6533 T6532 prep of,identification
R4486 T6534 T6533 pobj organisms,of
R4487 T6535 T6528 cc and,committee
R4488 T6536 T6537 det the,committee
R4489 T6537 T6528 conj committee,committee
R4490 T6538 T6537 nmod animal,committee
R4491 T6539 T6537 amod ethical,committee
R4492 T6540 T6520 punct ", ",judged
R4493 T6541 T6520 cc and,judged
R4494 T6542 T6543 auxpass were,conducted
R4495 T6543 T6520 conj conducted,judged
R4496 T6544 T6543 prep according,conducted
R4497 T6545 T6544 prep to,according
R4498 T6546 T6547 amod national,guidelines
R4499 T6547 T6545 pobj guidelines,to
R4500 T6548 T6546 cc and,national
R4501 T6549 T6546 conj international,national
R4502 T6550 T6520 punct .,judged