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PMC:1584416 / 28456-29566 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T5301 0-4 WP denotes What
T5303 5-9 VBZ denotes does
T5304 10-22 JJ denotes interallelic
T5305 23-38 NN denotes complementation
T5302 39-43 VB denotes tell
T5306 44-46 PRP denotes us
T5307 47-52 IN denotes about
T5308 53-56 DT denotes the
T5309 57-66 NN denotes mechanism
T5310 67-69 IN denotes of
T5311 70-73 NN denotes XPD
T5312 74-82 NN denotes function
T5313 82-83 . denotes ?
T5314 83-192 sentence denotes Interallelic complementation is most often observed in multimeric proteins with multiple functional domains.
T5315 84-96 JJ denotes Interallelic
T5316 97-112 NN denotes complementation
T5318 113-115 VBZ denotes is
T5319 116-120 RBS denotes most
T5320 121-126 RB denotes often
T5317 127-135 VBN denotes observed
T5321 136-138 IN denotes in
T5322 139-149 JJ denotes multimeric
T5323 150-158 NN denotes proteins
T5324 159-163 IN denotes with
T5325 164-172 JJ denotes multiple
T5327 173-183 JJ denotes functional
T5326 184-191 NNS denotes domains
T5328 191-192 . denotes .
T5329 192-411 sentence denotes Unfortunately, the structure–function relationship between disease-causing mutations and XPD functional domains, including detailed structural information on XPD or even its stoichiometry within TFIIH, remains unknown.
T5330 193-206 RB denotes Unfortunately
T5332 206-208 , denotes ,
T5333 208-211 DT denotes the
T5335 212-221 NN denotes structure
T5337 221-222 HYPH denotes –
T5336 222-230 NN denotes function
T5334 231-243 NN denotes relationship
T5338 244-251 IN denotes between
T5339 252-259 NN denotes disease
T5341 259-260 HYPH denotes -
T5340 260-267 VBG denotes causing
T5342 268-277 NNS denotes mutations
T5343 278-281 CC denotes and
T5344 282-285 NN denotes XPD
T5346 286-296 JJ denotes functional
T5345 297-304 NNS denotes domains
T5347 304-306 , denotes ,
T5348 306-315 VBG denotes including
T5349 316-324 JJ denotes detailed
T5351 325-335 JJ denotes structural
T5350 336-347 NN denotes information
T5352 348-350 IN denotes on
T5353 351-354 NN denotes XPD
T5354 355-357 CC denotes or
T5355 358-362 RB denotes even
T5357 363-366 PRP$ denotes its
T5356 367-380 NN denotes stoichiometry
T5358 381-387 IN denotes within
T5359 388-393 NN denotes TFIIH
T5360 393-395 , denotes ,
T5331 395-402 VBZ denotes remains
T5361 403-410 JJ denotes unknown
T5362 410-411 . denotes .
T5363 411-680 sentence denotes However, based on the ability of cell extracts that are defective in two different TFIIH components (XPD and XPB) to complement NER activity in vitro [26], it is likely that TFIIH (or its components) can either multimerise or exchange at least during the NER reaction.
T5364 412-419 RB denotes However
T5366 419-421 , denotes ,
T5367 421-426 VBN denotes based
T5368 427-429 IN denotes on
T5369 430-433 DT denotes the
T5370 434-441 NN denotes ability
T5371 442-444 IN denotes of
T5372 445-449 NN denotes cell
T5373 450-458 NNS denotes extracts
T5374 459-463 WDT denotes that
T5375 464-467 VBP denotes are
T5376 468-477 JJ denotes defective
T5377 478-480 IN denotes in
T5378 481-484 CD denotes two
T5380 485-494 JJ denotes different
T5381 495-500 NN denotes TFIIH
T5379 501-511 NNS denotes components
T5382 512-513 -LRB- denotes (
T5383 513-516 NN denotes XPD
T5384 517-520 CC denotes and
T5385 521-524 NN denotes XPB
T5386 524-525 -RRB- denotes )
T5387 526-528 TO denotes to
T5388 529-539 VB denotes complement
T5389 540-543 NN denotes NER
T5390 544-552 NN denotes activity
T5391 553-555 FW denotes in
T5392 556-561 FW denotes vitro
T5393 562-563 -LRB- denotes [
T5394 563-565 CD denotes 26
T5395 565-566 -RRB- denotes ]
T5396 566-568 , denotes ,
T5397 568-570 PRP denotes it
T5365 571-573 VBZ denotes is
T5398 574-580 JJ denotes likely
T5399 581-585 IN denotes that
T5401 586-591 NN denotes TFIIH
T5402 592-593 -LRB- denotes (
T5403 593-595 CC denotes or
T5404 596-599 PRP$ denotes its
T5405 600-610 NNS denotes components
T5406 610-611 -RRB- denotes )
T5407 612-615 MD denotes can
T5408 616-622 CC denotes either
T5400 623-634 VB denotes multimerise
T5409 635-637 CC denotes or
T5410 638-646 VB denotes exchange
T5411 647-649 RB denotes at
T5412 650-655 RBS denotes least
T5413 656-662 IN denotes during
T5414 663-666 DT denotes the
T5416 667-670 NN denotes NER
T5415 671-679 NN denotes reaction
T5417 679-680 . denotes .
T5418 680-753 sentence denotes Furthermore, XPD is known to be a “loosely bound” subunit of TFIIH [27].
T5419 681-692 RB denotes Furthermore
T5421 692-694 , denotes ,
T5422 694-697 NN denotes XPD
T5423 698-700 VBZ denotes is
T5420 701-706 VBN denotes known
T5424 707-709 TO denotes to
T5425 710-712 VB denotes be
T5426 713-714 DT denotes a
T5428 715-716 RB denotes “
T5429 716-723 RB denotes loosely
T5430 724-729 VBN denotes bound
T5431 729-730 '' denotes ”
T5427 731-738 NN denotes subunit
T5432 739-741 IN denotes of
T5433 742-747 NN denotes TFIIH
T5434 748-749 -LRB- denotes [
T5435 749-751 CD denotes 27
T5436 751-752 -RRB- denotes ]
T5437 752-753 . denotes .
T5438 753-1110 sentence denotes We thus envisage the molecular mechanism of interallelic complementation to involve the exchange of XPD molecules within the TFIIH complex or turnover of TFIIH complexes containing different XPD molecules at the site of DNA damage during the course of the global genome as well as transcription-coupled repair of either UV-induced or endogenous DNA damage.
T5439 754-756 PRP denotes We
T5441 757-761 RB denotes thus
T5440 762-770 VBP denotes envisage
T5442 771-774 DT denotes the
T5444 775-784 JJ denotes molecular
T5443 785-794 NN denotes mechanism
T5446 795-797 IN denotes of
T5447 798-810 JJ denotes interallelic
T5448 811-826 NN denotes complementation
T5449 827-829 TO denotes to
T5445 830-837 VB denotes involve
T5450 838-841 DT denotes the
T5451 842-850 NN denotes exchange
T5452 851-853 IN denotes of
T5453 854-857 NN denotes XPD
T5454 858-867 NNS denotes molecules
T5455 868-874 IN denotes within
T5456 875-878 DT denotes the
T5458 879-884 NN denotes TFIIH
T5457 885-892 NN denotes complex
T5459 893-895 CC denotes or
T5460 896-904 NN denotes turnover
T5461 905-907 IN denotes of
T5462 908-913 NN denotes TFIIH
T5463 914-923 NNS denotes complexes
T5464 924-934 VBG denotes containing
T5465 935-944 JJ denotes different
T5467 945-948 NN denotes XPD
T5466 949-958 NNS denotes molecules
T5468 959-961 IN denotes at
T5469 962-965 DT denotes the
T5470 966-970 NN denotes site
T5471 971-973 IN denotes of
T5472 974-977 NN denotes DNA
T5473 978-984 NN denotes damage
T5474 985-991 IN denotes during
T5475 992-995 DT denotes the
T5476 996-1002 NN denotes course
T5477 1003-1005 IN denotes of
T5478 1006-1009 DT denotes the
T5480 1010-1016 JJ denotes global
T5479 1017-1023 NN denotes genome
T5481 1024-1026 RB denotes as
T5483 1027-1031 RB denotes well
T5482 1032-1034 IN denotes as
T5484 1035-1048 NN denotes transcription
T5486 1048-1049 HYPH denotes -
T5485 1049-1056 VBN denotes coupled
T5487 1057-1063 NN denotes repair
T5488 1064-1066 IN denotes of
T5489 1067-1073 CC denotes either
T5491 1074-1076 NN denotes UV
T5493 1076-1077 HYPH denotes -
T5492 1077-1084 VBN denotes induced
T5494 1085-1087 CC denotes or
T5495 1088-1098 JJ denotes endogenous
T5496 1099-1102 NN denotes DNA
T5490 1103-1109 NN denotes damage
T5497 1109-1110 . denotes .
R3569 T5301 T5302 dep What,tell
R3570 T5303 T5302 aux does,tell
R3571 T5304 T5305 amod interallelic,complementation
R3572 T5305 T5302 nsubj complementation,tell
R3573 T5306 T5302 dobj us,tell
R3574 T5307 T5302 prep about,tell
R3575 T5308 T5309 det the,mechanism
R3576 T5309 T5307 pobj mechanism,about
R3577 T5310 T5309 prep of,mechanism
R3578 T5311 T5312 compound XPD,function
R3579 T5312 T5310 pobj function,of
R3580 T5313 T5302 punct ?,tell
R3581 T5315 T5316 amod Interallelic,complementation
R3582 T5316 T5317 nsubjpass complementation,observed
R3583 T5318 T5317 auxpass is,observed
R3584 T5319 T5320 advmod most,often
R3585 T5320 T5317 advmod often,observed
R3586 T5321 T5317 prep in,observed
R3587 T5322 T5323 amod multimeric,proteins
R3588 T5323 T5321 pobj proteins,in
R3589 T5324 T5323 prep with,proteins
R3590 T5325 T5326 amod multiple,domains
R3591 T5326 T5324 pobj domains,with
R3592 T5327 T5326 amod functional,domains
R3593 T5328 T5317 punct .,observed
R3594 T5330 T5331 advmod Unfortunately,remains
R3595 T5332 T5331 punct ", ",remains
R3596 T5333 T5334 det the,relationship
R3597 T5334 T5331 nsubj relationship,remains
R3598 T5335 T5336 compound structure,function
R3599 T5336 T5334 compound function,relationship
R3600 T5337 T5336 punct –,function
R3601 T5338 T5334 prep between,relationship
R3602 T5339 T5340 npadvmod disease,causing
R3603 T5340 T5342 amod causing,mutations
R3604 T5341 T5340 punct -,causing
R3605 T5342 T5338 pobj mutations,between
R3606 T5343 T5342 cc and,mutations
R3607 T5344 T5345 nmod XPD,domains
R3608 T5345 T5342 conj domains,mutations
R3609 T5346 T5345 amod functional,domains
R3610 T5347 T5334 punct ", ",relationship
R3611 T5348 T5334 prep including,relationship
R3612 T5349 T5350 amod detailed,information
R3613 T5350 T5348 pobj information,including
R3614 T5351 T5350 amod structural,information
R3615 T5352 T5350 prep on,information
R3616 T5353 T5352 pobj XPD,on
R3617 T5354 T5353 cc or,XPD
R3618 T5355 T5356 advmod even,stoichiometry
R3619 T5356 T5353 conj stoichiometry,XPD
R3620 T5357 T5356 poss its,stoichiometry
R3621 T5358 T5350 prep within,information
R3622 T5359 T5358 pobj TFIIH,within
R3623 T5360 T5331 punct ", ",remains
R3624 T5361 T5331 acomp unknown,remains
R3625 T5362 T5331 punct .,remains
R3626 T5364 T5365 advmod However,is
R3627 T5366 T5365 punct ", ",is
R3628 T5367 T5365 prep based,is
R3629 T5368 T5367 prep on,based
R3630 T5369 T5370 det the,ability
R3631 T5370 T5368 pobj ability,on
R3632 T5371 T5370 prep of,ability
R3633 T5372 T5373 compound cell,extracts
R3634 T5373 T5371 pobj extracts,of
R3635 T5374 T5375 dep that,are
R3636 T5375 T5373 relcl are,extracts
R3637 T5376 T5375 acomp defective,are
R3638 T5377 T5376 prep in,defective
R3639 T5378 T5379 nummod two,components
R3640 T5379 T5377 pobj components,in
R3641 T5380 T5379 amod different,components
R3642 T5381 T5379 compound TFIIH,components
R3643 T5382 T5379 punct (,components
R3644 T5383 T5379 appos XPD,components
R3645 T5384 T5383 cc and,XPD
R3646 T5385 T5383 conj XPB,XPD
R3647 T5386 T5370 punct ),ability
R3648 T5387 T5388 aux to,complement
R3649 T5388 T5370 acl complement,ability
R3650 T5389 T5390 compound NER,activity
R3651 T5390 T5388 dobj activity,complement
R3652 T5391 T5392 advmod in,vitro
R3653 T5392 T5388 advmod vitro,complement
R3654 T5393 T5394 punct [,26
R3655 T5394 T5370 parataxis 26,ability
R3656 T5395 T5394 punct ],26
R3657 T5396 T5365 punct ", ",is
R3658 T5397 T5365 nsubj it,is
R3659 T5398 T5365 acomp likely,is
R3660 T5399 T5400 mark that,multimerise
R3661 T5400 T5365 ccomp multimerise,is
R3662 T5401 T5400 nsubj TFIIH,multimerise
R3663 T5402 T5401 punct (,TFIIH
R3664 T5403 T5401 cc or,TFIIH
R3665 T5404 T5405 poss its,components
R3666 T5405 T5401 conj components,TFIIH
R3667 T5406 T5400 punct ),multimerise
R3668 T5407 T5400 aux can,multimerise
R3669 T5408 T5400 preconj either,multimerise
R3670 T5409 T5400 cc or,multimerise
R3671 T5410 T5400 conj exchange,multimerise
R3672 T5411 T5412 advmod at,least
R3673 T5412 T5413 advmod least,during
R3674 T5413 T5410 prep during,exchange
R3675 T5414 T5415 det the,reaction
R3676 T5415 T5413 pobj reaction,during
R3677 T5416 T5415 compound NER,reaction
R3678 T5417 T5365 punct .,is
R3679 T5419 T5420 advmod Furthermore,known
R3680 T5421 T5420 punct ", ",known
R3681 T5422 T5420 nsubjpass XPD,known
R3682 T5423 T5420 auxpass is,known
R3683 T5424 T5425 aux to,be
R3684 T5425 T5420 xcomp be,known
R3685 T5426 T5427 det a,subunit
R3686 T5427 T5425 attr subunit,be
R3687 T5428 T5427 advmod “,subunit
R3688 T5429 T5430 advmod loosely,bound
R3689 T5430 T5427 amod bound,subunit
R3690 T5431 T5427 punct ”,subunit
R3691 T5432 T5427 prep of,subunit
R3692 T5433 T5432 pobj TFIIH,of
R3693 T5434 T5435 punct [,27
R3694 T5435 T5420 parataxis 27,known
R3695 T5436 T5435 punct ],27
R3696 T5437 T5420 punct .,known
R3697 T5439 T5440 nsubj We,envisage
R3698 T5441 T5440 advmod thus,envisage
R3699 T5442 T5443 det the,mechanism
R3700 T5443 T5445 nsubj mechanism,involve
R3701 T5444 T5443 amod molecular,mechanism
R3702 T5445 T5440 ccomp involve,envisage
R3703 T5446 T5443 prep of,mechanism
R3704 T5447 T5448 amod interallelic,complementation
R3705 T5448 T5446 pobj complementation,of
R3706 T5449 T5445 aux to,involve
R3707 T5450 T5451 det the,exchange
R3708 T5451 T5445 dobj exchange,involve
R3709 T5452 T5451 prep of,exchange
R3710 T5453 T5454 compound XPD,molecules
R3711 T5454 T5452 pobj molecules,of
R3712 T5455 T5451 prep within,exchange
R3713 T5456 T5457 det the,complex
R3714 T5457 T5455 pobj complex,within
R3715 T5458 T5457 compound TFIIH,complex
R3716 T5459 T5451 cc or,exchange
R3717 T5460 T5451 conj turnover,exchange
R3718 T5461 T5460 prep of,turnover
R3719 T5462 T5463 compound TFIIH,complexes
R3720 T5463 T5461 pobj complexes,of
R3721 T5464 T5463 acl containing,complexes
R3722 T5465 T5466 amod different,molecules
R3723 T5466 T5464 dobj molecules,containing
R3724 T5467 T5466 compound XPD,molecules
R3725 T5468 T5460 prep at,turnover
R3726 T5469 T5470 det the,site
R3727 T5470 T5468 pobj site,at
R3728 T5471 T5470 prep of,site
R3729 T5472 T5473 compound DNA,damage
R3730 T5473 T5471 pobj damage,of
R3731 T5474 T5460 prep during,turnover
R3732 T5475 T5476 det the,course
R3733 T5476 T5474 pobj course,during
R3734 T5477 T5476 prep of,course
R3735 T5478 T5479 det the,genome
R3736 T5479 T5477 pobj genome,of
R3737 T5480 T5479 amod global,genome
R3738 T5481 T5482 advmod as,as
R3739 T5482 T5451 cc as,exchange
R3740 T5483 T5482 advmod well,as
R3741 T5484 T5485 npadvmod transcription,coupled
R3742 T5485 T5487 amod coupled,repair
R3743 T5486 T5485 punct -,coupled
R3744 T5487 T5451 conj repair,exchange
R3745 T5488 T5487 prep of,repair
R3746 T5489 T5490 preconj either,damage
R3747 T5490 T5488 pobj damage,of
R3748 T5491 T5492 npadvmod UV,induced
R3749 T5492 T5490 amod induced,damage
R3750 T5493 T5492 punct -,induced
R3751 T5494 T5492 cc or,induced
R3752 T5495 T5492 conj endogenous,induced
R3753 T5496 T5490 compound DNA,damage
R3754 T5497 T5440 punct .,envisage