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PMC:1584416 / 26105-28408 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4805 0-5 NN denotes TFIIH
T4806 6-8 IN denotes in
T4807 9-22 NN denotes Transcription
T4808 23-26 CC denotes and
T4809 27-33 NN denotes Repair
T4810 33-35 : denotes :
T4811 35-45 NNS denotes Mechanisms
T4812 46-48 IN denotes of
T4813 49-52 NN denotes XPD
T4815 53-60 NN denotes Disease
T4814 61-71 NN denotes Pleiotropy
T4816 71-361 sentence denotes We observed differences in the ability of XpdTTD versus homozygous lethal Xpd†XPCS and Xpd†XP alleles to function in two transcription-related phenotypes separated in the organism by both time and space: embryonic lethality and terminal differentiation of enucleating skin and blood cells.
T4817 72-74 PRP denotes We
T4818 75-83 VBD denotes observed
T4819 84-95 NNS denotes differences
T4820 96-98 IN denotes in
T4821 99-102 DT denotes the
T4822 103-110 NN denotes ability
T4823 111-113 IN denotes of
T4824 114-120 NN denotes XpdTTD
T4825 121-127 CC denotes versus
T4826 128-138 JJ denotes homozygous
T4828 139-145 JJ denotes lethal
T4829 146-154 NN denotes Xpd†XPCS
T4830 155-158 CC denotes and
T4831 159-165 NN denotes Xpd†XP
T4827 166-173 NNS denotes alleles
T4832 174-176 TO denotes to
T4833 177-185 VB denotes function
T4834 186-188 IN denotes in
T4835 189-192 CD denotes two
T4837 193-206 NN denotes transcription
T4839 206-207 HYPH denotes -
T4838 207-214 VBN denotes related
T4836 215-225 NNS denotes phenotypes
T4840 226-235 VBN denotes separated
T4841 236-238 IN denotes in
T4842 239-242 DT denotes the
T4843 243-251 NN denotes organism
T4844 252-254 IN denotes by
T4845 255-259 CC denotes both
T4846 260-264 NN denotes time
T4847 265-268 CC denotes and
T4848 269-274 NN denotes space
T4849 274-276 : denotes :
T4850 276-285 JJ denotes embryonic
T4851 286-295 NN denotes lethality
T4852 296-299 CC denotes and
T4853 300-308 JJ denotes terminal
T4854 309-324 NN denotes differentiation
T4855 325-327 IN denotes of
T4856 328-339 VBG denotes enucleating
T4857 340-344 NN denotes skin
T4858 345-348 CC denotes and
T4859 349-354 NN denotes blood
T4860 355-360 NNS denotes cells
T4861 360-361 . denotes .
T4862 361-541 sentence denotes The preblastocyst-stage homozygous lethality shared by the XpdKO, Xpd†XPCS, and Xpd†XP alleles most likely reflects a defect in basal transcription that is incompatible with life.
T4863 362-365 DT denotes The
T4865 366-379 NN denotes preblastocyst
T4867 379-380 HYPH denotes -
T4866 380-385 NN denotes stage
T4868 386-396 JJ denotes homozygous
T4864 397-406 NN denotes lethality
T4870 407-413 VBN denotes shared
T4871 414-416 IN denotes by
T4872 417-420 DT denotes the
T4874 421-426 NN denotes XpdKO
T4875 426-428 , denotes ,
T4876 428-436 NN denotes Xpd†XPCS
T4877 436-438 , denotes ,
T4878 438-441 CC denotes and
T4879 442-448 NN denotes Xpd†XP
T4873 449-456 NNS denotes alleles
T4880 457-461 RBS denotes most
T4881 462-468 RB denotes likely
T4869 469-477 VBZ denotes reflects
T4882 478-479 DT denotes a
T4883 480-486 NN denotes defect
T4884 487-489 IN denotes in
T4885 490-495 JJ denotes basal
T4886 496-509 NN denotes transcription
T4887 510-514 WDT denotes that
T4888 515-517 VBZ denotes is
T4889 518-530 JJ denotes incompatible
T4890 531-535 IN denotes with
T4891 536-540 NN denotes life
T4892 540-541 . denotes .
T4893 541-662 sentence denotes In XpdTTD/ †XPCS and XpdTTD/ †XP compound heterozygous mice, embryonic lethality was fully rescued by the XpdTTD allele.
T4894 542-544 IN denotes In
T4896 545-551 NN denotes XpdTTD
T4898 551-552 HYPH denotes /
T4897 552-558 NN denotes  †XPCS
T4900 559-562 CC denotes and
T4901 563-569 NN denotes XpdTTD
T4903 569-570 HYPH denotes /
T4902 570-574 NN denotes  †XP
T4904 575-583 NN denotes compound
T4905 584-596 JJ denotes heterozygous
T4899 597-601 NNS denotes mice
T4906 601-603 , denotes ,
T4907 603-612 JJ denotes embryonic
T4908 613-622 NN denotes lethality
T4909 623-626 VBD denotes was
T4910 627-632 RB denotes fully
T4895 633-640 VBN denotes rescued
T4911 641-643 IN denotes by
T4912 644-647 DT denotes the
T4914 648-654 NN denotes XpdTTD
T4913 655-661 NN denotes allele
T4915 661-662 . denotes .
T4916 662-927 sentence denotes Because embryonic lethality was also fully rescued in XpdTTD/KO hemizygous mice, the XpdTTD allele can be considered as wt and thus dominant to each of the homozygous lethal alleles (XpdKO, Xpd†XPCS, and Xpd†XP) with respect to this particular phenotype (Table 2).
T4917 663-670 IN denotes Because
T4919 671-680 JJ denotes embryonic
T4920 681-690 NN denotes lethality
T4921 691-694 VBD denotes was
T4922 695-699 RB denotes also
T4923 700-705 RB denotes fully
T4918 706-713 VBN denotes rescued
T4925 714-716 IN denotes in
T4926 717-723 NN denotes XpdTTD
T4928 723-724 HYPH denotes /
T4927 724-726 NN denotes KO
T4930 727-737 JJ denotes hemizygous
T4929 738-742 NNS denotes mice
T4931 742-744 , denotes ,
T4932 744-747 DT denotes the
T4934 748-754 NN denotes XpdTTD
T4933 755-761 NN denotes allele
T4935 762-765 MD denotes can
T4936 766-768 VB denotes be
T4924 769-779 VBN denotes considered
T4937 780-782 IN denotes as
T4938 783-785 NN denotes wt
T4939 786-789 CC denotes and
T4940 790-794 RB denotes thus
T4941 795-803 JJ denotes dominant
T4942 804-806 IN denotes to
T4943 807-811 DT denotes each
T4944 812-814 IN denotes of
T4945 815-818 DT denotes the
T4947 819-829 JJ denotes homozygous
T4948 830-836 JJ denotes lethal
T4946 837-844 NNS denotes alleles
T4949 845-846 -LRB- denotes (
T4950 846-851 NN denotes XpdKO
T4951 851-853 , denotes ,
T4952 853-861 NN denotes Xpd†XPCS
T4953 861-863 , denotes ,
T4954 863-866 CC denotes and
T4955 867-873 NN denotes Xpd†XP
T4956 873-874 -RRB- denotes )
T4957 875-879 IN denotes with
T4958 880-887 NN denotes respect
T4959 888-890 IN denotes to
T4960 891-895 DT denotes this
T4962 896-906 JJ denotes particular
T4961 907-916 NN denotes phenotype
T4963 917-918 -LRB- denotes (
T4964 918-923 NN denotes Table
T4965 924-925 CD denotes 2
T4966 925-926 -RRB- denotes )
T4967 926-927 . denotes .
T4968 927-1187 sentence denotes TTD-specific cutaneous and anaemic features, on the other hand, are thought to result from a specific kind of transcriptional insufficiency caused by depletion of unstable TFIIH during the terminal differentiation of skin, hair-shaft, and blood cells [16,24].
T4969 928-931 NN denotes TTD
T4971 931-932 HYPH denotes -
T4970 932-940 JJ denotes specific
T4973 941-950 JJ denotes cutaneous
T4974 951-954 CC denotes and
T4975 955-962 JJ denotes anaemic
T4972 963-971 NNS denotes features
T4977 971-973 , denotes ,
T4978 973-975 IN denotes on
T4979 976-979 DT denotes the
T4981 980-985 JJ denotes other
T4980 986-990 NN denotes hand
T4982 990-992 , denotes ,
T4983 992-995 VBP denotes are
T4976 996-1003 VBN denotes thought
T4984 1004-1006 TO denotes to
T4985 1007-1013 VB denotes result
T4986 1014-1018 IN denotes from
T4987 1019-1020 DT denotes a
T4989 1021-1029 JJ denotes specific
T4988 1030-1034 NN denotes kind
T4990 1035-1037 IN denotes of
T4991 1038-1053 JJ denotes transcriptional
T4992 1054-1067 NN denotes insufficiency
T4993 1068-1074 VBN denotes caused
T4994 1075-1077 IN denotes by
T4995 1078-1087 NN denotes depletion
T4996 1088-1090 IN denotes of
T4997 1091-1099 JJ denotes unstable
T4998 1100-1105 NN denotes TFIIH
T4999 1106-1112 IN denotes during
T5000 1113-1116 DT denotes the
T5002 1117-1125 JJ denotes terminal
T5001 1126-1141 NN denotes differentiation
T5003 1142-1144 IN denotes of
T5004 1145-1149 NN denotes skin
T5006 1149-1151 , denotes ,
T5007 1151-1155 NN denotes hair
T5009 1155-1156 HYPH denotes -
T5008 1156-1161 NN denotes shaft
T5010 1161-1163 , denotes ,
T5011 1163-1166 CC denotes and
T5012 1167-1172 NN denotes blood
T5005 1173-1178 NNS denotes cells
T5013 1179-1180 -LRB- denotes [
T5015 1180-1182 CD denotes 16
T5016 1182-1183 , denotes ,
T5014 1183-1185 CD denotes 24
T5017 1185-1186 -RRB- denotes ]
T5018 1186-1187 . denotes .
T5019 1187-1432 sentence denotes In compound heterozygous mice, both homozygous lethal Xpd†XPCS and Xpd†XP alleles were able to alleviate XpdTTD-specific cutaneous and anaemic features and can thus be defined as dominant over the XpdTTD allele with respect to these phenotypes.
T5020 1188-1190 IN denotes In
T5022 1191-1199 NN denotes compound
T5024 1200-1212 JJ denotes heterozygous
T5023 1213-1217 NNS denotes mice
T5025 1217-1219 , denotes ,
T5026 1219-1223 DT denotes both
T5028 1224-1234 JJ denotes homozygous
T5029 1235-1241 JJ denotes lethal
T5030 1242-1250 NN denotes Xpd†XPCS
T5031 1251-1254 CC denotes and
T5032 1255-1261 NN denotes Xpd†XP
T5027 1262-1269 NNS denotes alleles
T5021 1270-1274 VBD denotes were
T5033 1275-1279 JJ denotes able
T5034 1280-1282 TO denotes to
T5035 1283-1292 VB denotes alleviate
T5036 1293-1299 NN denotes XpdTTD
T5038 1299-1300 HYPH denotes -
T5037 1300-1308 JJ denotes specific
T5040 1309-1318 JJ denotes cutaneous
T5041 1319-1322 CC denotes and
T5042 1323-1330 JJ denotes anaemic
T5039 1331-1339 NNS denotes features
T5043 1340-1343 CC denotes and
T5044 1344-1347 MD denotes can
T5046 1348-1352 RB denotes thus
T5047 1353-1355 VB denotes be
T5045 1356-1363 VBN denotes defined
T5048 1364-1366 IN denotes as
T5049 1367-1375 JJ denotes dominant
T5050 1376-1380 IN denotes over
T5051 1381-1384 DT denotes the
T5053 1385-1391 NN denotes XpdTTD
T5052 1392-1398 NN denotes allele
T5054 1399-1403 IN denotes with
T5055 1404-1411 NN denotes respect
T5056 1412-1414 IN denotes to
T5057 1415-1420 DT denotes these
T5058 1421-1431 NNS denotes phenotypes
T5059 1431-1432 . denotes .
T5060 1432-1649 sentence denotes We conclude that the defects leading to embryonic lethality and aberrant terminal differentiation of the skin, hair, and blood represent two qualitatively and/or quantitatively different transcriptional deficiencies.
T5061 1433-1435 PRP denotes We
T5062 1436-1444 VBP denotes conclude
T5063 1445-1449 IN denotes that
T5065 1450-1453 DT denotes the
T5066 1454-1461 NNS denotes defects
T5067 1462-1469 VBG denotes leading
T5068 1470-1472 IN denotes to
T5069 1473-1482 JJ denotes embryonic
T5070 1483-1492 NN denotes lethality
T5071 1493-1496 CC denotes and
T5072 1497-1505 JJ denotes aberrant
T5074 1506-1514 JJ denotes terminal
T5073 1515-1530 NN denotes differentiation
T5075 1531-1533 IN denotes of
T5076 1534-1537 DT denotes the
T5077 1538-1542 NN denotes skin
T5078 1542-1544 , denotes ,
T5079 1544-1548 NN denotes hair
T5080 1548-1550 , denotes ,
T5081 1550-1553 CC denotes and
T5082 1554-1559 NN denotes blood
T5064 1560-1569 VBP denotes represent
T5083 1570-1573 CD denotes two
T5085 1574-1587 RB denotes qualitatively
T5087 1588-1591 CC denotes and
T5088 1591-1592 HYPH denotes /
T5089 1592-1594 CC denotes or
T5090 1595-1609 RB denotes quantitatively
T5086 1610-1619 JJ denotes different
T5091 1620-1635 JJ denotes transcriptional
T5084 1636-1648 NNS denotes deficiencies
T5092 1648-1649 . denotes .
T5093 1649-1840 sentence denotes During early embryonic development, XpdTTD is dominant over the Xpd†XPCS and Xpd†XP alleles, whereas later in the ontogenesis of skin, hair-shaft, and blood cells, the situation is reversed.
T5094 1650-1656 IN denotes During
T5096 1657-1662 JJ denotes early
T5098 1663-1672 JJ denotes embryonic
T5097 1673-1684 NN denotes development
T5099 1684-1686 , denotes ,
T5100 1686-1692 NN denotes XpdTTD
T5095 1693-1695 VBZ denotes is
T5101 1696-1704 JJ denotes dominant
T5102 1705-1709 IN denotes over
T5103 1710-1713 DT denotes the
T5105 1714-1722 NN denotes Xpd†XPCS
T5106 1723-1726 CC denotes and
T5107 1727-1733 NN denotes Xpd†XP
T5104 1734-1741 NNS denotes alleles
T5108 1741-1743 , denotes ,
T5109 1743-1750 IN denotes whereas
T5111 1751-1756 RB denotes later
T5112 1757-1759 IN denotes in
T5113 1760-1763 DT denotes the
T5114 1764-1775 NN denotes ontogenesis
T5115 1776-1778 IN denotes of
T5116 1779-1783 NN denotes skin
T5117 1783-1785 , denotes ,
T5118 1785-1789 NN denotes hair
T5120 1789-1790 HYPH denotes -
T5119 1790-1795 NN denotes shaft
T5121 1795-1797 , denotes ,
T5122 1797-1800 CC denotes and
T5123 1801-1806 NN denotes blood
T5124 1807-1812 NNS denotes cells
T5125 1812-1814 , denotes ,
T5126 1814-1817 DT denotes the
T5127 1818-1827 NN denotes situation
T5128 1828-1830 VBZ denotes is
T5110 1831-1839 VBN denotes reversed
T5129 1839-1840 . denotes .
T5130 1840-2083 sentence denotes In its role in the repair of UV photolesions, the Xpd†XPCS allele imparted a clear UV survival benefit over a single XpdTTD allele or two XpdXPCS alleles independent of expression levels, which is consistent with interallelic complementation.
T5131 1841-1843 IN denotes In
T5133 1844-1847 PRP$ denotes its
T5134 1848-1852 NN denotes role
T5135 1853-1855 IN denotes in
T5136 1856-1859 DT denotes the
T5137 1860-1866 NN denotes repair
T5138 1867-1869 IN denotes of
T5139 1870-1872 NN denotes UV
T5140 1873-1885 NNS denotes photolesions
T5141 1885-1887 , denotes ,
T5142 1887-1890 DT denotes the
T5144 1891-1899 NN denotes Xpd†XPCS
T5143 1900-1906 NN denotes allele
T5132 1907-1915 VBD denotes imparted
T5145 1916-1917 DT denotes a
T5147 1918-1923 JJ denotes clear
T5148 1924-1926 NN denotes UV
T5149 1927-1935 NN denotes survival
T5146 1936-1943 NN denotes benefit
T5150 1944-1948 IN denotes over
T5151 1949-1950 DT denotes a
T5153 1951-1957 JJ denotes single
T5154 1958-1964 NN denotes XpdTTD
T5152 1965-1971 NN denotes allele
T5155 1972-1974 CC denotes or
T5156 1975-1978 CD denotes two
T5158 1979-1986 NN denotes XpdXPCS
T5157 1987-1994 NNS denotes alleles
T5159 1995-2006 JJ denotes independent
T5160 2007-2009 IN denotes of
T5161 2010-2020 NN denotes expression
T5162 2021-2027 NNS denotes levels
T5163 2027-2029 , denotes ,
T5164 2029-2034 WDT denotes which
T5165 2035-2037 VBZ denotes is
T5166 2038-2048 JJ denotes consistent
T5167 2049-2053 IN denotes with
T5168 2054-2066 JJ denotes interallelic
T5169 2067-2082 NN denotes complementation
T5170 2082-2083 . denotes .
T5171 2083-2303 sentence denotes However, the observation that no other cellular or biochemical UV-related parameters were improved in XpdTTD/ †XPCS argues against complementation of this repair activity in the rescue of TTD progeroid symptoms in vivo.
T5172 2084-2091 RB denotes However
T5174 2091-2093 , denotes ,
T5175 2093-2096 DT denotes the
T5176 2097-2108 NN denotes observation
T5177 2109-2113 IN denotes that
T5179 2114-2116 DT denotes no
T5181 2117-2122 JJ denotes other
T5182 2123-2131 JJ denotes cellular
T5183 2132-2134 CC denotes or
T5184 2135-2146 JJ denotes biochemical
T5185 2147-2149 NN denotes UV
T5187 2149-2150 HYPH denotes -
T5186 2150-2157 VBN denotes related
T5180 2158-2168 NNS denotes parameters
T5188 2169-2173 VBD denotes were
T5178 2174-2182 VBN denotes improved
T5189 2183-2185 IN denotes in
T5190 2186-2192 NN denotes XpdTTD
T5192 2192-2193 HYPH denotes /
T5191 2193-2199 NN denotes  †XPCS
T5173 2200-2206 VBZ denotes argues
T5193 2207-2214 IN denotes against
T5194 2215-2230 NN denotes complementation
T5195 2231-2233 IN denotes of
T5196 2234-2238 DT denotes this
T5198 2239-2245 NN denotes repair
T5197 2246-2254 NN denotes activity
T5199 2255-2257 IN denotes in
T5200 2258-2261 DT denotes the
T5201 2262-2268 NN denotes rescue
T5202 2269-2271 IN denotes of
T5203 2272-2275 NN denotes TTD
T5205 2276-2285 JJ denotes progeroid
T5204 2286-2294 NNS denotes symptoms
T5206 2295-2297 FW denotes in
T5207 2298-2302 FW denotes vivo
T5208 2302-2303 . denotes .
R3180 T4806 T4805 prep in,TFIIH
R3181 T4807 T4806 pobj Transcription,in
R3182 T4808 T4807 cc and,Transcription
R3183 T4809 T4807 conj Repair,Transcription
R3184 T4810 T4805 punct : ,TFIIH
R3185 T4811 T4805 appos Mechanisms,TFIIH
R3186 T4812 T4811 prep of,Mechanisms
R3187 T4813 T4814 compound XPD,Pleiotropy
R3188 T4814 T4812 pobj Pleiotropy,of
R3189 T4815 T4814 compound Disease,Pleiotropy
R3190 T4817 T4818 nsubj We,observed
R3191 T4819 T4818 dobj differences,observed
R3192 T4820 T4819 prep in,differences
R3193 T4821 T4822 det the,ability
R3194 T4822 T4820 pobj ability,in
R3195 T4823 T4822 prep of,ability
R3196 T4824 T4823 pobj XpdTTD,of
R3197 T4825 T4824 cc versus,XpdTTD
R3198 T4826 T4827 amod homozygous,alleles
R3199 T4827 T4824 conj alleles,XpdTTD
R3200 T4828 T4827 amod lethal,alleles
R3201 T4829 T4827 nmod Xpd†XPCS,alleles
R3202 T4830 T4829 cc and,Xpd†XPCS
R3203 T4831 T4829 conj Xpd†XP,Xpd†XPCS
R3204 T4832 T4833 aux to,function
R3205 T4833 T4822 acl function,ability
R3206 T4834 T4833 prep in,function
R3207 T4835 T4836 nummod two,phenotypes
R3208 T4836 T4834 pobj phenotypes,in
R3209 T4837 T4838 npadvmod transcription,related
R3210 T4838 T4836 amod related,phenotypes
R3211 T4839 T4838 punct -,related
R3212 T4840 T4836 acl separated,phenotypes
R3213 T4841 T4840 prep in,separated
R3214 T4842 T4843 det the,organism
R3215 T4843 T4841 pobj organism,in
R3216 T4844 T4840 prep by,separated
R3217 T4845 T4846 preconj both,time
R3218 T4846 T4844 pobj time,by
R3219 T4847 T4846 cc and,time
R3220 T4848 T4846 conj space,time
R3221 T4849 T4819 punct : ,differences
R3222 T4850 T4851 amod embryonic,lethality
R3223 T4851 T4819 appos lethality,differences
R3224 T4852 T4851 cc and,lethality
R3225 T4853 T4854 amod terminal,differentiation
R3226 T4854 T4851 conj differentiation,lethality
R3227 T4855 T4854 prep of,differentiation
R3228 T4856 T4857 amod enucleating,skin
R3229 T4857 T4855 pobj skin,of
R3230 T4858 T4857 cc and,skin
R3231 T4859 T4860 compound blood,cells
R3232 T4860 T4857 conj cells,skin
R3233 T4861 T4818 punct .,observed
R3234 T4863 T4864 det The,lethality
R3235 T4864 T4869 nsubj lethality,reflects
R3236 T4865 T4866 nmod preblastocyst,stage
R3237 T4866 T4864 nmod stage,lethality
R3238 T4867 T4866 punct -,stage
R3239 T4868 T4864 amod homozygous,lethality
R3240 T4870 T4864 acl shared,lethality
R3241 T4871 T4870 agent by,shared
R3242 T4872 T4873 det the,alleles
R3243 T4873 T4871 pobj alleles,by
R3244 T4874 T4873 nmod XpdKO,alleles
R3245 T4875 T4874 punct ", ",XpdKO
R3246 T4876 T4874 conj Xpd†XPCS,XpdKO
R3247 T4877 T4876 punct ", ",Xpd†XPCS
R3248 T4878 T4876 cc and,Xpd†XPCS
R3249 T4879 T4876 conj Xpd†XP,Xpd†XPCS
R3250 T4880 T4881 advmod most,likely
R3251 T4881 T4869 advmod likely,reflects
R3252 T4882 T4883 det a,defect
R3253 T4883 T4869 dobj defect,reflects
R3254 T4884 T4883 prep in,defect
R3255 T4885 T4886 amod basal,transcription
R3256 T4886 T4884 pobj transcription,in
R3257 T4887 T4888 dep that,is
R3258 T4888 T4883 relcl is,defect
R3259 T4889 T4888 acomp incompatible,is
R3260 T4890 T4889 prep with,incompatible
R3261 T4891 T4890 pobj life,with
R3262 T4892 T4869 punct .,reflects
R3263 T4894 T4895 prep In,rescued
R3264 T4896 T4897 nmod XpdTTD, †XPCS
R3265 T4897 T4899 nmod  †XPCS,mice
R3266 T4898 T4897 punct /, †XPCS
R3267 T4899 T4894 pobj mice,In
R3268 T4900 T4897 cc and, †XPCS
R3269 T4901 T4902 compound XpdTTD, †XP
R3270 T4902 T4897 conj  †XP, †XPCS
R3271 T4903 T4902 punct /, †XP
R3272 T4904 T4899 nmod compound,mice
R3273 T4905 T4899 amod heterozygous,mice
R3274 T4906 T4895 punct ", ",rescued
R3275 T4907 T4908 amod embryonic,lethality
R3276 T4908 T4895 nsubjpass lethality,rescued
R3277 T4909 T4895 auxpass was,rescued
R3278 T4910 T4895 advmod fully,rescued
R3279 T4911 T4895 agent by,rescued
R3280 T4912 T4913 det the,allele
R3281 T4913 T4911 pobj allele,by
R3282 T4914 T4913 compound XpdTTD,allele
R3283 T4915 T4895 punct .,rescued
R3284 T4917 T4918 mark Because,rescued
R3285 T4918 T4924 advcl rescued,considered
R3286 T4919 T4920 amod embryonic,lethality
R3287 T4920 T4918 nsubjpass lethality,rescued
R3288 T4921 T4918 auxpass was,rescued
R3289 T4922 T4918 advmod also,rescued
R3290 T4923 T4918 advmod fully,rescued
R3291 T4925 T4918 prep in,rescued
R3292 T4926 T4927 nmod XpdTTD,KO
R3293 T4927 T4929 nmod KO,mice
R3294 T4928 T4927 punct /,KO
R3295 T4929 T4925 pobj mice,in
R3296 T4930 T4929 amod hemizygous,mice
R3297 T4931 T4924 punct ", ",considered
R3298 T4932 T4933 det the,allele
R3299 T4933 T4924 nsubjpass allele,considered
R3300 T4934 T4933 compound XpdTTD,allele
R3301 T4935 T4924 aux can,considered
R3302 T4936 T4924 auxpass be,considered
R3303 T4937 T4924 prep as,considered
R3304 T4938 T4937 pobj wt,as
R3305 T4939 T4938 cc and,wt
R3306 T4940 T4941 advmod thus,dominant
R3307 T4941 T4938 conj dominant,wt
R3308 T4942 T4941 prep to,dominant
R3309 T4943 T4942 pobj each,to
R3310 T4944 T4943 prep of,each
R3311 T4945 T4946 det the,alleles
R3312 T4946 T4944 pobj alleles,of
R3313 T4947 T4946 amod homozygous,alleles
R3314 T4948 T4946 amod lethal,alleles
R3315 T4949 T4950 punct (,XpdKO
R3316 T4950 T4946 parataxis XpdKO,alleles
R3317 T4951 T4950 punct ", ",XpdKO
R3318 T4952 T4950 conj Xpd†XPCS,XpdKO
R3319 T4953 T4952 punct ", ",Xpd†XPCS
R3320 T4954 T4952 cc and,Xpd†XPCS
R3321 T4955 T4952 conj Xpd†XP,Xpd†XPCS
R3322 T4956 T4950 punct ),XpdKO
R3323 T4957 T4941 prep with,dominant
R3324 T4958 T4957 pobj respect,with
R3325 T4959 T4958 prep to,respect
R3326 T4960 T4961 det this,phenotype
R3327 T4961 T4959 pobj phenotype,to
R3328 T4962 T4961 amod particular,phenotype
R3329 T4963 T4964 punct (,Table
R3330 T4964 T4924 parataxis Table,considered
R3331 T4965 T4964 nummod 2,Table
R3332 T4966 T4964 punct ),Table
R3333 T4967 T4924 punct .,considered
R3334 T4969 T4970 npadvmod TTD,specific
R3335 T4970 T4972 amod specific,features
R3336 T4971 T4970 punct -,specific
R3337 T4972 T4976 nsubjpass features,thought
R3338 T4973 T4972 amod cutaneous,features
R3339 T4974 T4973 cc and,cutaneous
R3340 T4975 T4973 conj anaemic,cutaneous
R3341 T4977 T4976 punct ", ",thought
R3342 T4978 T4976 prep on,thought
R3343 T4979 T4980 det the,hand
R3344 T4980 T4978 pobj hand,on
R3345 T4981 T4980 amod other,hand
R3346 T4982 T4976 punct ", ",thought
R3347 T4983 T4976 auxpass are,thought
R3348 T4984 T4985 aux to,result
R3349 T4985 T4976 xcomp result,thought
R3350 T4986 T4985 prep from,result
R3351 T4987 T4988 det a,kind
R3352 T4988 T4986 pobj kind,from
R3353 T4989 T4988 amod specific,kind
R3354 T4990 T4988 prep of,kind
R3355 T4991 T4992 amod transcriptional,insufficiency
R3356 T4992 T4990 pobj insufficiency,of
R3357 T4993 T4988 acl caused,kind
R3358 T4994 T4993 agent by,caused
R3359 T4995 T4994 pobj depletion,by
R3360 T4996 T4995 prep of,depletion
R3361 T4997 T4998 amod unstable,TFIIH
R3362 T4998 T4996 pobj TFIIH,of
R3363 T4999 T4995 prep during,depletion
R3364 T5000 T5001 det the,differentiation
R3365 T5001 T4999 pobj differentiation,during
R3366 T5002 T5001 amod terminal,differentiation
R3367 T5003 T5001 prep of,differentiation
R3368 T5004 T5005 nmod skin,cells
R3369 T5005 T5003 pobj cells,of
R3370 T5006 T5004 punct ", ",skin
R3371 T5007 T5008 compound hair,shaft
R3372 T5008 T5004 conj shaft,skin
R3373 T5009 T5008 punct -,shaft
R3374 T5010 T5008 punct ", ",shaft
R3375 T5011 T5008 cc and,shaft
R3376 T5012 T5008 conj blood,shaft
R3377 T5013 T5014 punct [,24
R3378 T5014 T4976 parataxis 24,thought
R3379 T5015 T5014 nummod 16,24
R3380 T5016 T5014 punct ",",24
R3381 T5017 T5014 punct ],24
R3382 T5018 T4976 punct .,thought
R3383 T5020 T5021 prep In,were
R3384 T5022 T5023 nmod compound,mice
R3385 T5023 T5020 pobj mice,In
R3386 T5024 T5023 amod heterozygous,mice
R3387 T5025 T5021 punct ", ",were
R3388 T5026 T5027 det both,alleles
R3389 T5027 T5021 nsubj alleles,were
R3390 T5028 T5027 amod homozygous,alleles
R3391 T5029 T5027 amod lethal,alleles
R3392 T5030 T5027 nmod Xpd†XPCS,alleles
R3393 T5031 T5030 cc and,Xpd†XPCS
R3394 T5032 T5030 conj Xpd†XP,Xpd†XPCS
R3395 T5033 T5021 acomp able,were
R3396 T5034 T5035 aux to,alleviate
R3397 T5035 T5033 xcomp alleviate,able
R3398 T5036 T5037 npadvmod XpdTTD,specific
R3399 T5037 T5039 amod specific,features
R3400 T5038 T5037 punct -,specific
R3401 T5039 T5035 dobj features,alleviate
R3402 T5040 T5039 amod cutaneous,features
R3403 T5041 T5040 cc and,cutaneous
R3404 T5042 T5040 conj anaemic,cutaneous
R3405 T5043 T5021 cc and,were
R3406 T5044 T5045 aux can,defined
R3407 T5045 T5021 conj defined,were
R3408 T5046 T5045 advmod thus,defined
R3409 T5047 T5045 auxpass be,defined
R3410 T5048 T5045 prep as,defined
R3411 T5049 T5048 amod dominant,as
R3412 T5050 T5045 prep over,defined
R3413 T5051 T5052 det the,allele
R3414 T5052 T5050 pobj allele,over
R3415 T5053 T5052 compound XpdTTD,allele
R3416 T5054 T5045 prep with,defined
R3417 T5055 T5054 pobj respect,with
R3418 T5056 T5055 prep to,respect
R3419 T5057 T5058 det these,phenotypes
R3420 T5058 T5056 pobj phenotypes,to
R3421 T5059 T5021 punct .,were
R3422 T5061 T5062 nsubj We,conclude
R3423 T5063 T5064 mark that,represent
R3424 T5064 T5062 ccomp represent,conclude
R3425 T5065 T5066 det the,defects
R3426 T5066 T5064 nsubj defects,represent
R3427 T5067 T5066 acl leading,defects
R3428 T5068 T5067 prep to,leading
R3429 T5069 T5070 amod embryonic,lethality
R3430 T5070 T5068 pobj lethality,to
R3431 T5071 T5070 cc and,lethality
R3432 T5072 T5073 amod aberrant,differentiation
R3433 T5073 T5070 conj differentiation,lethality
R3434 T5074 T5073 amod terminal,differentiation
R3435 T5075 T5073 prep of,differentiation
R3436 T5076 T5077 det the,skin
R3437 T5077 T5075 pobj skin,of
R3438 T5078 T5077 punct ", ",skin
R3439 T5079 T5077 conj hair,skin
R3440 T5080 T5079 punct ", ",hair
R3441 T5081 T5079 cc and,hair
R3442 T5082 T5079 conj blood,hair
R3443 T5083 T5084 nummod two,deficiencies
R3444 T5084 T5064 dobj deficiencies,represent
R3445 T5085 T5086 advmod qualitatively,different
R3446 T5086 T5084 amod different,deficiencies
R3447 T5087 T5085 cc and,qualitatively
R3448 T5088 T5087 punct /,and
R3449 T5089 T5087 cc or,and
R3450 T5090 T5085 conj quantitatively,qualitatively
R3451 T5091 T5084 amod transcriptional,deficiencies
R3452 T5092 T5062 punct .,conclude
R3453 T5094 T5095 prep During,is
R3454 T5096 T5097 amod early,development
R3455 T5097 T5094 pobj development,During
R3456 T5098 T5097 amod embryonic,development
R3457 T5099 T5095 punct ", ",is
R3458 T5100 T5095 nsubj XpdTTD,is
R3459 T5101 T5095 acomp dominant,is
R3460 T5102 T5101 prep over,dominant
R3461 T5103 T5104 det the,alleles
R3462 T5104 T5102 pobj alleles,over
R3463 T5105 T5104 nmod Xpd†XPCS,alleles
R3464 T5106 T5105 cc and,Xpd†XPCS
R3465 T5107 T5105 conj Xpd†XP,Xpd†XPCS
R3466 T5108 T5095 punct ", ",is
R3467 T5109 T5110 mark whereas,reversed
R3468 T5110 T5095 advcl reversed,is
R3469 T5111 T5110 advmod later,reversed
R3470 T5112 T5111 prep in,later
R3471 T5113 T5114 det the,ontogenesis
R3472 T5114 T5112 pobj ontogenesis,in
R3473 T5115 T5114 prep of,ontogenesis
R3474 T5116 T5115 pobj skin,of
R3475 T5117 T5116 punct ", ",skin
R3476 T5118 T5119 compound hair,shaft
R3477 T5119 T5116 conj shaft,skin
R3478 T5120 T5119 punct -,shaft
R3479 T5121 T5119 punct ", ",shaft
R3480 T5122 T5119 cc and,shaft
R3481 T5123 T5124 compound blood,cells
R3482 T5124 T5119 conj cells,shaft
R3483 T5125 T5110 punct ", ",reversed
R3484 T5126 T5127 det the,situation
R3485 T5127 T5110 nsubjpass situation,reversed
R3486 T5128 T5110 auxpass is,reversed
R3487 T5129 T5095 punct .,is
R3488 T5131 T5132 prep In,imparted
R3489 T5133 T5134 poss its,role
R3490 T5134 T5131 pobj role,In
R3491 T5135 T5134 prep in,role
R3492 T5136 T5137 det the,repair
R3493 T5137 T5135 pobj repair,in
R3494 T5138 T5137 prep of,repair
R3495 T5139 T5140 compound UV,photolesions
R3496 T5140 T5138 pobj photolesions,of
R3497 T5141 T5132 punct ", ",imparted
R3498 T5142 T5143 det the,allele
R3499 T5143 T5132 nsubj allele,imparted
R3500 T5144 T5143 compound Xpd†XPCS,allele
R3501 T5145 T5146 det a,benefit
R3502 T5146 T5132 dobj benefit,imparted
R3503 T5147 T5146 amod clear,benefit
R3504 T5148 T5146 compound UV,benefit
R3505 T5149 T5146 compound survival,benefit
R3506 T5150 T5146 prep over,benefit
R3507 T5151 T5152 det a,allele
R3508 T5152 T5150 pobj allele,over
R3509 T5153 T5152 amod single,allele
R3510 T5154 T5152 compound XpdTTD,allele
R3511 T5155 T5152 cc or,allele
R3512 T5156 T5157 nummod two,alleles
R3513 T5157 T5152 conj alleles,allele
R3514 T5158 T5157 compound XpdXPCS,alleles
R3515 T5159 T5146 amod independent,benefit
R3516 T5160 T5159 prep of,independent
R3517 T5161 T5162 compound expression,levels
R3518 T5162 T5160 pobj levels,of
R3519 T5163 T5132 punct ", ",imparted
R3520 T5164 T5165 dep which,is
R3521 T5165 T5132 advcl is,imparted
R3522 T5166 T5165 acomp consistent,is
R3523 T5167 T5166 prep with,consistent
R3524 T5168 T5169 amod interallelic,complementation
R3525 T5169 T5167 pobj complementation,with
R3526 T5170 T5132 punct .,imparted
R3527 T5172 T5173 advmod However,argues
R3528 T5174 T5173 punct ", ",argues
R3529 T5175 T5176 det the,observation
R3530 T5176 T5173 nsubj observation,argues
R3531 T5177 T5178 mark that,improved
R3532 T5178 T5176 acl improved,observation
R3533 T5179 T5180 det no,parameters
R3534 T5180 T5178 nsubjpass parameters,improved
R3535 T5181 T5180 amod other,parameters
R3536 T5182 T5180 amod cellular,parameters
R3537 T5183 T5182 cc or,cellular
R3538 T5184 T5182 conj biochemical,cellular
R3539 T5185 T5186 npadvmod UV,related
R3540 T5186 T5180 amod related,parameters
R3541 T5187 T5186 punct -,related
R3542 T5188 T5178 auxpass were,improved
R3543 T5189 T5178 prep in,improved
R3544 T5190 T5191 compound XpdTTD, †XPCS
R3545 T5191 T5189 pobj  †XPCS,in
R3546 T5192 T5191 punct /, †XPCS
R3547 T5193 T5173 prep against,argues
R3548 T5194 T5193 pobj complementation,against
R3549 T5195 T5194 prep of,complementation
R3550 T5196 T5197 det this,activity
R3551 T5197 T5195 pobj activity,of
R3552 T5198 T5197 compound repair,activity
R3553 T5199 T5194 prep in,complementation
R3554 T5200 T5201 det the,rescue
R3555 T5201 T5199 pobj rescue,in
R3556 T5202 T5201 prep of,rescue
R3557 T5203 T5204 nmod TTD,symptoms
R3558 T5204 T5202 pobj symptoms,of
R3559 T5205 T5204 amod progeroid,symptoms
R3560 T5206 T5207 advmod in,vivo
R3561 T5207 T5201 advmod vivo,rescue
R3562 T5208 T5173 punct .,argues