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PMC:1584416 / 24251-26103 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T4259 0-10 NN denotes Dissection
T4260 11-13 IN denotes of
T4261 14-23 JJ denotes Biallelic
T4262 24-31 NNS denotes Effects
T4263 32-36 IN denotes from
T4264 37-42 JJ denotes other
T4265 43-55 NNS denotes Determinants
T4266 56-58 IN denotes of
T4267 59-68 NN denotes Phenotype
T4268 68-360 sentence denotes Although phenotypic consequences, referred to here as biallelic effects, resulting from two different mutant alleles in compound heterozygote patients have been postulated, such effects have historically been difficult to distinguish from the influence of environment and genetic background.
T4269 69-77 IN denotes Although
T4271 78-88 JJ denotes phenotypic
T4272 89-101 NNS denotes consequences
T4273 101-103 , denotes ,
T4274 103-111 VBN denotes referred
T4275 112-114 IN denotes to
T4276 115-119 RB denotes here
T4277 120-122 IN denotes as
T4278 123-132 JJ denotes biallelic
T4279 133-140 NNS denotes effects
T4280 140-142 , denotes ,
T4281 142-151 VBG denotes resulting
T4282 152-156 IN denotes from
T4283 157-160 CD denotes two
T4285 161-170 JJ denotes different
T4286 171-177 JJ denotes mutant
T4284 178-185 NNS denotes alleles
T4287 186-188 IN denotes in
T4288 189-197 NN denotes compound
T4290 198-210 NN denotes heterozygote
T4289 211-219 NNS denotes patients
T4291 220-224 VBP denotes have
T4292 225-229 VBN denotes been
T4270 230-240 VBN denotes postulated
T4294 240-242 , denotes ,
T4295 242-246 JJ denotes such
T4296 247-254 NNS denotes effects
T4297 255-259 VBP denotes have
T4298 260-272 RB denotes historically
T4293 273-277 VBN denotes been
T4299 278-287 JJ denotes difficult
T4300 288-290 TO denotes to
T4301 291-302 VB denotes distinguish
T4302 303-307 IN denotes from
T4303 308-311 DT denotes the
T4304 312-321 NN denotes influence
T4305 322-324 IN denotes of
T4306 325-336 NN denotes environment
T4307 337-340 CC denotes and
T4308 341-348 JJ denotes genetic
T4309 349-359 NN denotes background
T4310 359-360 . denotes .
T4311 360-565 sentence denotes We used a genetically defined mammalian model system under controlled environmental conditions to reveal phenotypic effects attributable specifically to combinations of differentially mutated Xpd alleles.
T4312 361-363 PRP denotes We
T4313 364-368 VBD denotes used
T4314 369-370 DT denotes a
T4316 371-382 RB denotes genetically
T4317 383-390 VBN denotes defined
T4318 391-400 JJ denotes mammalian
T4319 401-406 NN denotes model
T4315 407-413 NN denotes system
T4320 414-419 IN denotes under
T4321 420-430 JJ denotes controlled
T4323 431-444 JJ denotes environmental
T4322 445-455 NNS denotes conditions
T4324 456-458 TO denotes to
T4325 459-465 VB denotes reveal
T4326 466-476 JJ denotes phenotypic
T4327 477-484 NNS denotes effects
T4328 485-497 JJ denotes attributable
T4329 498-510 RB denotes specifically
T4330 511-513 IN denotes to
T4331 514-526 NNS denotes combinations
T4332 527-529 IN denotes of
T4333 530-544 RB denotes differentially
T4334 545-552 VBN denotes mutated
T4336 553-556 NN denotes Xpd
T4335 557-564 NNS denotes alleles
T4337 564-565 . denotes .
T4338 565-625 sentence denotes The observed biallelic effects were of three general types.
T4339 566-569 DT denotes The
T4341 570-578 VBN denotes observed
T4342 579-588 JJ denotes biallelic
T4340 589-596 NNS denotes effects
T4343 597-601 VBD denotes were
T4344 602-604 IN denotes of
T4345 605-610 CD denotes three
T4347 611-618 JJ denotes general
T4346 619-624 NNS denotes types
T4348 624-625 . denotes .
T4349 625-813 sentence denotes In the first, the allele associated in a homozygous state with a phenotype closer to wt singularly determined the phenotypic outcome, a phenomenon widely known in human recessive disease.
T4350 626-628 IN denotes In
T4352 629-632 DT denotes the
T4353 633-638 JJ denotes first
T4354 638-640 , denotes ,
T4355 640-643 DT denotes the
T4356 644-650 NN denotes allele
T4357 651-661 VBN denotes associated
T4358 662-664 IN denotes in
T4359 665-666 DT denotes a
T4361 667-677 JJ denotes homozygous
T4360 678-683 NN denotes state
T4362 684-688 IN denotes with
T4363 689-690 DT denotes a
T4364 691-700 NN denotes phenotype
T4365 701-707 RBR denotes closer
T4366 708-710 IN denotes to
T4367 711-713 NN denotes wt
T4368 714-724 RB denotes singularly
T4351 725-735 VBN denotes determined
T4369 736-739 DT denotes the
T4371 740-750 JJ denotes phenotypic
T4370 751-758 NN denotes outcome
T4372 758-760 , denotes ,
T4373 760-761 DT denotes a
T4374 762-772 NN denotes phenomenon
T4375 773-779 RB denotes widely
T4376 780-785 VBN denotes known
T4377 786-788 IN denotes in
T4378 789-794 JJ denotes human
T4380 795-804 JJ denotes recessive
T4379 805-812 NN denotes disease
T4381 812-813 . denotes .
T4382 813-944 sentence denotes Because these Xpd alleles functioned at or near wt levels with respect to a particular function, we call these effects “dominant”.
T4383 814-821 IN denotes Because
T4385 822-827 DT denotes these
T4387 828-831 NN denotes Xpd
T4386 832-839 NNS denotes alleles
T4384 840-850 VBD denotes functioned
T4389 851-853 IN denotes at
T4390 854-856 CC denotes or
T4391 857-861 IN denotes near
T4392 862-864 NN denotes wt
T4393 865-871 NNS denotes levels
T4394 872-876 IN denotes with
T4395 877-884 NN denotes respect
T4396 885-887 IN denotes to
T4397 888-889 DT denotes a
T4399 890-900 JJ denotes particular
T4398 901-909 NN denotes function
T4400 909-911 , denotes ,
T4401 911-913 PRP denotes we
T4388 914-918 VBP denotes call
T4402 919-924 DT denotes these
T4403 925-932 NNS denotes effects
T4404 933-934 `` denotes “
T4405 934-942 JJ denotes dominant
T4406 942-943 '' denotes ”
T4407 943-944 . denotes .
T4408 944-1113 sentence denotes Such alleles can also be referred to as “separation of function” alleles, because they allow dissection of the roles of multifunctional proteins in specific phenotypes.
T4409 945-949 JJ denotes Such
T4410 950-957 NNS denotes alleles
T4412 958-961 MD denotes can
T4413 962-966 RB denotes also
T4414 967-969 VB denotes be
T4411 970-978 VBN denotes referred
T4415 979-981 IN denotes to
T4416 982-984 IN denotes as
T4417 985-986 `` denotes “
T4419 986-996 NN denotes separation
T4420 997-999 IN denotes of
T4421 1000-1008 NN denotes function
T4422 1008-1009 '' denotes ”
T4418 1010-1017 NNS denotes alleles
T4423 1017-1019 , denotes ,
T4424 1019-1026 IN denotes because
T4426 1027-1031 PRP denotes they
T4425 1032-1037 VBP denotes allow
T4427 1038-1048 NN denotes dissection
T4428 1049-1051 IN denotes of
T4429 1052-1055 DT denotes the
T4430 1056-1061 NNS denotes roles
T4431 1062-1064 IN denotes of
T4432 1065-1080 JJ denotes multifunctional
T4433 1081-1089 NN denotes proteins
T4434 1090-1092 IN denotes in
T4435 1093-1101 JJ denotes specific
T4436 1102-1112 NNS denotes phenotypes
T4437 1112-1113 . denotes .
T4438 1113-1490 sentence denotes Secondly, highlighting the potential relevance of current findings to all diploid organisms including humans was the observation that in one compound heterozygous animal, the Xpd allelic relationship could shift from A dominant |a recessive to A recessive |a dominant with respect to different phenotypes in a time-dependent and tissue-specific manner (see below and Table 2).
T4439 1114-1122 RB denotes Secondly
T4441 1122-1124 , denotes ,
T4442 1124-1136 VBG denotes highlighting
T4443 1137-1140 DT denotes the
T4445 1141-1150 JJ denotes potential
T4444 1151-1160 NN denotes relevance
T4446 1161-1163 IN denotes of
T4447 1164-1171 JJ denotes current
T4448 1172-1180 NNS denotes findings
T4449 1181-1183 IN denotes to
T4450 1184-1187 DT denotes all
T4452 1188-1195 JJ denotes diploid
T4451 1196-1205 NNS denotes organisms
T4453 1206-1215 VBG denotes including
T4454 1216-1222 NNS denotes humans
T4440 1223-1226 VBD denotes was
T4455 1227-1230 DT denotes the
T4456 1231-1242 NN denotes observation
T4457 1243-1247 IN denotes that
T4459 1248-1250 IN denotes in
T4460 1251-1254 CD denotes one
T4462 1255-1263 NN denotes compound
T4463 1264-1276 JJ denotes heterozygous
T4461 1277-1283 NN denotes animal
T4464 1283-1285 , denotes ,
T4465 1285-1288 DT denotes the
T4467 1289-1292 NN denotes Xpd
T4468 1293-1300 JJ denotes allelic
T4466 1301-1313 NN denotes relationship
T4469 1314-1319 MD denotes could
T4458 1320-1325 VB denotes shift
T4470 1326-1330 IN denotes from
T4471 1331-1341 JJ denotes A dominant
T4473 1342-1343 HYPH denotes |
T4472 1343-1354 JJ denotes a recessive
T4474 1355-1357 IN denotes to
T4475 1358-1369 JJ denotes A recessive
T4477 1370-1371 HYPH denotes |
T4476 1371-1381 JJ denotes a dominant
T4478 1382-1386 IN denotes with
T4479 1387-1394 NN denotes respect
T4480 1395-1397 IN denotes to
T4481 1398-1407 JJ denotes different
T4482 1408-1418 NNS denotes phenotypes
T4483 1419-1421 IN denotes in
T4484 1422-1423 DT denotes a
T4486 1424-1428 NN denotes time
T4488 1428-1429 HYPH denotes -
T4487 1429-1438 JJ denotes dependent
T4489 1439-1442 CC denotes and
T4490 1443-1449 NN denotes tissue
T4492 1449-1450 HYPH denotes -
T4491 1450-1458 JJ denotes specific
T4485 1459-1465 NN denotes manner
T4493 1466-1467 -LRB- denotes (
T4494 1467-1470 VB denotes see
T4495 1471-1476 RB denotes below
T4497 1477-1480 CC denotes and
T4496 1481-1486 NN denotes Table
T4498 1487-1488 CD denotes 2
T4499 1488-1489 -RRB- denotes )
T4500 1489-1490 . denotes .
T4501 1490-1677 sentence denotes In the third type of biallelic effect, known as interallelic complementation, two mutant alleles produced a phenotype closer to wt than either could alone in a homo- or hemizygous state.
T4502 1491-1493 IN denotes In
T4504 1494-1497 DT denotes the
T4506 1498-1503 JJ denotes third
T4505 1504-1508 NN denotes type
T4507 1509-1511 IN denotes of
T4508 1512-1521 JJ denotes biallelic
T4509 1522-1528 NN denotes effect
T4510 1528-1530 , denotes ,
T4511 1530-1535 VBN denotes known
T4512 1536-1538 IN denotes as
T4513 1539-1551 JJ denotes interallelic
T4514 1552-1567 NN denotes complementation
T4515 1567-1569 , denotes ,
T4516 1569-1572 CD denotes two
T4518 1573-1579 JJ denotes mutant
T4517 1580-1587 NNS denotes alleles
T4503 1588-1596 VBD denotes produced
T4519 1597-1598 DT denotes a
T4520 1599-1608 NN denotes phenotype
T4521 1609-1615 RBR denotes closer
T4522 1616-1618 IN denotes to
T4523 1619-1621 NN denotes wt
T4524 1622-1626 IN denotes than
T4526 1627-1633 DT denotes either
T4527 1634-1639 MD denotes could
T4525 1640-1645 RB denotes alone
T4528 1646-1648 IN denotes in
T4529 1649-1650 DT denotes a
T4531 1651-1655 AFX denotes homo
T4533 1655-1656 HYPH denotes -
T4534 1657-1659 CC denotes or
T4532 1660-1670 JJ denotes hemizygous
T4530 1671-1676 NN denotes state
T4535 1676-1677 . denotes .
T4536 1677-1852 sentence denotes As summarised in Table 2, examples of all types of biallelic effects were observed in a variety of Xpd-associated phenotypes, ranging from brittle hair to segmental progeria.
T4537 1678-1680 IN denotes As
T4538 1681-1691 VBN denotes summarised
T4540 1692-1694 IN denotes in
T4541 1695-1700 NN denotes Table
T4542 1701-1702 CD denotes 2
T4543 1702-1704 , denotes ,
T4544 1704-1712 NNS denotes examples
T4545 1713-1715 IN denotes of
T4546 1716-1719 DT denotes all
T4547 1720-1725 NNS denotes types
T4548 1726-1728 IN denotes of
T4549 1729-1738 JJ denotes biallelic
T4550 1739-1746 NNS denotes effects
T4551 1747-1751 VBD denotes were
T4539 1752-1760 VBN denotes observed
T4552 1761-1763 IN denotes in
T4553 1764-1765 DT denotes a
T4554 1766-1773 NN denotes variety
T4555 1774-1776 IN denotes of
T4556 1777-1780 NN denotes Xpd
T4558 1780-1781 HYPH denotes -
T4557 1781-1791 VBN denotes associated
T4559 1792-1802 NNS denotes phenotypes
T4560 1802-1804 , denotes ,
T4561 1804-1811 VBG denotes ranging
T4562 1812-1816 IN denotes from
T4563 1817-1824 JJ denotes brittle
T4564 1825-1829 NN denotes hair
T4565 1830-1832 IN denotes to
T4566 1833-1842 JJ denotes segmental
T4567 1843-1851 NN denotes progeria
T4568 1851-1852 . denotes .
R2877 T4260 T4259 prep of,Dissection
R2878 T4261 T4262 amod Biallelic,Effects
R2879 T4262 T4260 pobj Effects,of
R2880 T4263 T4259 prep from,Dissection
R2881 T4264 T4265 amod other,Determinants
R2882 T4265 T4263 pobj Determinants,from
R2883 T4266 T4265 prep of,Determinants
R2884 T4267 T4266 pobj Phenotype,of
R2885 T4269 T4270 mark Although,postulated
R2886 T4270 T4293 advcl postulated,been
R2887 T4271 T4272 amod phenotypic,consequences
R2888 T4272 T4270 nsubjpass consequences,postulated
R2889 T4273 T4272 punct ", ",consequences
R2890 T4274 T4272 acl referred,consequences
R2891 T4275 T4274 prep to,referred
R2892 T4276 T4274 advmod here,referred
R2893 T4277 T4274 prep as,referred
R2894 T4278 T4279 amod biallelic,effects
R2895 T4279 T4277 pobj effects,as
R2896 T4280 T4272 punct ", ",consequences
R2897 T4281 T4272 acl resulting,consequences
R2898 T4282 T4281 prep from,resulting
R2899 T4283 T4284 nummod two,alleles
R2900 T4284 T4282 pobj alleles,from
R2901 T4285 T4284 amod different,alleles
R2902 T4286 T4284 amod mutant,alleles
R2903 T4287 T4284 prep in,alleles
R2904 T4288 T4289 compound compound,patients
R2905 T4289 T4287 pobj patients,in
R2906 T4290 T4289 compound heterozygote,patients
R2907 T4291 T4270 aux have,postulated
R2908 T4292 T4270 auxpass been,postulated
R2909 T4294 T4293 punct ", ",been
R2910 T4295 T4296 amod such,effects
R2911 T4296 T4293 nsubj effects,been
R2912 T4297 T4293 aux have,been
R2913 T4298 T4293 advmod historically,been
R2914 T4299 T4293 acomp difficult,been
R2915 T4300 T4301 aux to,distinguish
R2916 T4301 T4299 xcomp distinguish,difficult
R2917 T4302 T4301 prep from,distinguish
R2918 T4303 T4304 det the,influence
R2919 T4304 T4302 pobj influence,from
R2920 T4305 T4304 prep of,influence
R2921 T4306 T4305 pobj environment,of
R2922 T4307 T4306 cc and,environment
R2923 T4308 T4309 amod genetic,background
R2924 T4309 T4306 conj background,environment
R2925 T4310 T4293 punct .,been
R2926 T4312 T4313 nsubj We,used
R2927 T4314 T4315 det a,system
R2928 T4315 T4313 dobj system,used
R2929 T4316 T4317 advmod genetically,defined
R2930 T4317 T4315 amod defined,system
R2931 T4318 T4315 amod mammalian,system
R2932 T4319 T4315 compound model,system
R2933 T4320 T4313 prep under,used
R2934 T4321 T4322 amod controlled,conditions
R2935 T4322 T4320 pobj conditions,under
R2936 T4323 T4322 amod environmental,conditions
R2937 T4324 T4325 aux to,reveal
R2938 T4325 T4313 advcl reveal,used
R2939 T4326 T4327 amod phenotypic,effects
R2940 T4327 T4325 dobj effects,reveal
R2941 T4328 T4327 amod attributable,effects
R2942 T4329 T4330 advmod specifically,to
R2943 T4330 T4328 prep to,attributable
R2944 T4331 T4330 pobj combinations,to
R2945 T4332 T4331 prep of,combinations
R2946 T4333 T4334 advmod differentially,mutated
R2947 T4334 T4335 amod mutated,alleles
R2948 T4335 T4332 pobj alleles,of
R2949 T4336 T4335 compound Xpd,alleles
R2950 T4337 T4313 punct .,used
R2951 T4339 T4340 det The,effects
R2952 T4340 T4343 nsubj effects,were
R2953 T4341 T4340 amod observed,effects
R2954 T4342 T4340 amod biallelic,effects
R2955 T4344 T4343 prep of,were
R2956 T4345 T4346 nummod three,types
R2957 T4346 T4344 pobj types,of
R2958 T4347 T4346 amod general,types
R2959 T4348 T4343 punct .,were
R2960 T4350 T4351 prep In,determined
R2961 T4352 T4353 det the,first
R2962 T4353 T4350 pobj first,In
R2963 T4354 T4351 punct ", ",determined
R2964 T4355 T4356 det the,allele
R2965 T4356 T4351 nsubj allele,determined
R2966 T4357 T4356 acl associated,allele
R2967 T4358 T4357 prep in,associated
R2968 T4359 T4360 det a,state
R2969 T4360 T4358 pobj state,in
R2970 T4361 T4360 amod homozygous,state
R2971 T4362 T4357 prep with,associated
R2972 T4363 T4364 det a,phenotype
R2973 T4364 T4362 pobj phenotype,with
R2974 T4365 T4366 advmod closer,to
R2975 T4366 T4364 amod to,phenotype
R2976 T4367 T4366 pobj wt,to
R2977 T4368 T4351 advmod singularly,determined
R2978 T4369 T4370 det the,outcome
R2979 T4370 T4351 dobj outcome,determined
R2980 T4371 T4370 amod phenotypic,outcome
R2981 T4372 T4351 punct ", ",determined
R2982 T4373 T4374 det a,phenomenon
R2983 T4374 T4351 npadvmod phenomenon,determined
R2984 T4375 T4376 advmod widely,known
R2985 T4376 T4374 acl known,phenomenon
R2986 T4377 T4376 prep in,known
R2987 T4378 T4379 amod human,disease
R2988 T4379 T4377 pobj disease,in
R2989 T4380 T4379 amod recessive,disease
R2990 T4381 T4351 punct .,determined
R2991 T4383 T4384 mark Because,functioned
R2992 T4384 T4388 advcl functioned,call
R2993 T4385 T4386 det these,alleles
R2994 T4386 T4384 nsubj alleles,functioned
R2995 T4387 T4386 compound Xpd,alleles
R2996 T4389 T4384 prep at,functioned
R2997 T4390 T4389 cc or,at
R2998 T4391 T4389 conj near,at
R2999 T4392 T4393 compound wt,levels
R3000 T4393 T4391 pobj levels,near
R3001 T4394 T4384 prep with,functioned
R3002 T4395 T4394 pobj respect,with
R3003 T4396 T4395 prep to,respect
R3004 T4397 T4398 det a,function
R3005 T4398 T4396 pobj function,to
R3006 T4399 T4398 amod particular,function
R3007 T4400 T4388 punct ", ",call
R3008 T4401 T4388 nsubj we,call
R3009 T4402 T4403 det these,effects
R3010 T4403 T4388 dobj effects,call
R3011 T4404 T4388 punct “,call
R3012 T4405 T4388 oprd dominant,call
R3013 T4406 T4388 punct ”,call
R3014 T4407 T4388 punct .,call
R3015 T4409 T4410 amod Such,alleles
R3016 T4410 T4411 nsubjpass alleles,referred
R3017 T4412 T4411 aux can,referred
R3018 T4413 T4411 advmod also,referred
R3019 T4414 T4411 auxpass be,referred
R3020 T4415 T4411 prep to,referred
R3021 T4416 T4411 prep as,referred
R3022 T4417 T4418 punct “,alleles
R3023 T4418 T4416 pobj alleles,as
R3024 T4419 T4418 nmod separation,alleles
R3025 T4420 T4419 prep of,separation
R3026 T4421 T4420 pobj function,of
R3027 T4422 T4418 punct ”,alleles
R3028 T4423 T4411 punct ", ",referred
R3029 T4424 T4425 mark because,allow
R3030 T4425 T4411 advcl allow,referred
R3031 T4426 T4425 nsubj they,allow
R3032 T4427 T4425 dobj dissection,allow
R3033 T4428 T4427 prep of,dissection
R3034 T4429 T4430 det the,roles
R3035 T4430 T4428 pobj roles,of
R3036 T4431 T4430 prep of,roles
R3037 T4432 T4433 amod multifunctional,proteins
R3038 T4433 T4431 pobj proteins,of
R3039 T4434 T4425 prep in,allow
R3040 T4435 T4436 amod specific,phenotypes
R3041 T4436 T4434 pobj phenotypes,in
R3042 T4437 T4411 punct .,referred
R3043 T4439 T4440 advmod Secondly,was
R3044 T4441 T4440 punct ", ",was
R3045 T4442 T4440 dep highlighting,was
R3046 T4443 T4444 det the,relevance
R3047 T4444 T4442 dobj relevance,highlighting
R3048 T4445 T4444 amod potential,relevance
R3049 T4446 T4444 prep of,relevance
R3050 T4447 T4448 amod current,findings
R3051 T4448 T4446 pobj findings,of
R3052 T4449 T4444 prep to,relevance
R3053 T4450 T4451 det all,organisms
R3054 T4451 T4449 pobj organisms,to
R3055 T4452 T4451 amod diploid,organisms
R3056 T4453 T4451 prep including,organisms
R3057 T4454 T4453 pobj humans,including
R3058 T4455 T4456 det the,observation
R3059 T4456 T4440 nsubj observation,was
R3060 T4457 T4458 mark that,shift
R3061 T4458 T4456 acl shift,observation
R3062 T4459 T4458 prep in,shift
R3063 T4460 T4461 nummod one,animal
R3064 T4461 T4459 pobj animal,in
R3065 T4462 T4461 nmod compound,animal
R3066 T4463 T4461 amod heterozygous,animal
R3067 T4464 T4458 punct ", ",shift
R3068 T4465 T4466 det the,relationship
R3069 T4466 T4458 nsubj relationship,shift
R3070 T4467 T4466 nmod Xpd,relationship
R3071 T4468 T4466 amod allelic,relationship
R3072 T4469 T4458 aux could,shift
R3073 T4470 T4458 prep from,shift
R3074 T4471 T4472 amod A dominant,a recessive
R3075 T4472 T4470 pobj a recessive,from
R3076 T4473 T4472 punct |,a recessive
R3077 T4474 T4470 prep to,from
R3078 T4475 T4476 amod A recessive,a dominant
R3079 T4476 T4474 pobj a dominant,to
R3080 T4477 T4476 punct |,a dominant
R3081 T4478 T4458 prep with,shift
R3082 T4479 T4478 pobj respect,with
R3083 T4480 T4479 prep to,respect
R3084 T4481 T4482 amod different,phenotypes
R3085 T4482 T4480 pobj phenotypes,to
R3086 T4483 T4458 prep in,shift
R3087 T4484 T4485 det a,manner
R3088 T4485 T4483 pobj manner,in
R3089 T4486 T4487 npadvmod time,dependent
R3090 T4487 T4485 amod dependent,manner
R3091 T4488 T4487 punct -,dependent
R3092 T4489 T4487 cc and,dependent
R3093 T4490 T4491 npadvmod tissue,specific
R3094 T4491 T4487 conj specific,dependent
R3095 T4492 T4491 punct -,specific
R3096 T4493 T4494 punct (,see
R3097 T4494 T4458 parataxis see,shift
R3098 T4495 T4496 advmod below,Table
R3099 T4496 T4494 dobj Table,see
R3100 T4497 T4496 cc and,Table
R3101 T4498 T4496 nummod 2,Table
R3102 T4499 T4494 punct ),see
R3103 T4500 T4440 punct .,was
R3104 T4502 T4503 prep In,produced
R3105 T4504 T4505 det the,type
R3106 T4505 T4502 pobj type,In
R3107 T4506 T4505 amod third,type
R3108 T4507 T4505 prep of,type
R3109 T4508 T4509 amod biallelic,effect
R3110 T4509 T4507 pobj effect,of
R3111 T4510 T4505 punct ", ",type
R3112 T4511 T4505 acl known,type
R3113 T4512 T4511 prep as,known
R3114 T4513 T4514 amod interallelic,complementation
R3115 T4514 T4512 pobj complementation,as
R3116 T4515 T4503 punct ", ",produced
R3117 T4516 T4517 nummod two,alleles
R3118 T4517 T4503 nsubj alleles,produced
R3119 T4518 T4517 amod mutant,alleles
R3120 T4519 T4520 det a,phenotype
R3121 T4520 T4503 dobj phenotype,produced
R3122 T4521 T4522 advmod closer,to
R3123 T4522 T4520 amod to,phenotype
R3124 T4523 T4522 pobj wt,to
R3125 T4524 T4525 mark than,alone
R3126 T4525 T4522 advcl alone,to
R3127 T4526 T4525 nsubj either,alone
R3128 T4527 T4525 aux could,alone
R3129 T4528 T4525 prep in,alone
R3130 T4529 T4530 det a,state
R3131 T4530 T4528 pobj state,in
R3132 T4531 T4532 advmod homo,hemizygous
R3133 T4532 T4530 amod hemizygous,state
R3134 T4533 T4532 punct -,hemizygous
R3135 T4534 T4532 cc or,hemizygous
R3136 T4535 T4503 punct .,produced
R3137 T4537 T4538 mark As,summarised
R3138 T4538 T4539 advcl summarised,observed
R3139 T4540 T4538 prep in,summarised
R3140 T4541 T4540 pobj Table,in
R3141 T4542 T4541 nummod 2,Table
R3142 T4543 T4539 punct ", ",observed
R3143 T4544 T4539 nsubjpass examples,observed
R3144 T4545 T4544 prep of,examples
R3145 T4546 T4547 det all,types
R3146 T4547 T4545 pobj types,of
R3147 T4548 T4547 prep of,types
R3148 T4549 T4550 amod biallelic,effects
R3149 T4550 T4548 pobj effects,of
R3150 T4551 T4539 auxpass were,observed
R3151 T4552 T4539 prep in,observed
R3152 T4553 T4554 det a,variety
R3153 T4554 T4552 pobj variety,in
R3154 T4555 T4554 prep of,variety
R3155 T4556 T4557 npadvmod Xpd,associated
R3156 T4557 T4559 amod associated,phenotypes
R3157 T4558 T4557 punct -,associated
R3158 T4559 T4555 pobj phenotypes,of
R3159 T4560 T4554 punct ", ",variety
R3160 T4561 T4554 acl ranging,variety
R3161 T4562 T4561 prep from,ranging
R3162 T4563 T4564 amod brittle,hair
R3163 T4564 T4562 pobj hair,from
R3164 T4565 T4562 prep to,from
R3165 T4566 T4567 amod segmental,progeria
R3166 T4567 T4565 pobj progeria,to
R3167 T4568 T4539 punct .,observed