Id |
Subject |
Object |
Predicate |
Lexical cue |
T565 |
0-12 |
JJ |
denotes |
Interallelic |
T566 |
13-28 |
NN |
denotes |
complementation |
T568 |
29-31 |
VBZ |
denotes |
is |
T567 |
32-39 |
VBN |
denotes |
defined |
T569 |
40-42 |
IN |
denotes |
as |
T570 |
43-46 |
DT |
denotes |
the |
T571 |
47-54 |
NN |
denotes |
ability |
T572 |
55-57 |
IN |
denotes |
of |
T573 |
58-61 |
CD |
denotes |
two |
T575 |
62-76 |
RB |
denotes |
differentially |
T576 |
77-84 |
VBN |
denotes |
mutated |
T574 |
85-92 |
NNS |
denotes |
alleles |
T577 |
93-95 |
TO |
denotes |
to |
T578 |
96-104 |
VB |
denotes |
function |
T579 |
105-111 |
RBR |
denotes |
better |
T580 |
112-120 |
RB |
denotes |
together |
T581 |
121-125 |
IN |
denotes |
than |
T583 |
126-132 |
DT |
denotes |
either |
T582 |
133-136 |
MD |
denotes |
can |
T584 |
137-139 |
IN |
denotes |
on |
T585 |
140-143 |
PRP$ |
denotes |
its |
T586 |
144-147 |
JJ |
denotes |
own |
T587 |
147-148 |
. |
denotes |
. |
T588 |
148-295 |
sentence |
denotes |
Despite its near universality in lower organisms [1], its potential to contribute to clinical heterogeneity in human disease is seldom considered. |
T589 |
149-156 |
IN |
denotes |
Despite |
T591 |
157-160 |
PRP$ |
denotes |
its |
T593 |
161-165 |
JJ |
denotes |
near |
T592 |
166-178 |
NN |
denotes |
universality |
T594 |
179-181 |
IN |
denotes |
in |
T595 |
182-187 |
JJR |
denotes |
lower |
T596 |
188-197 |
NNS |
denotes |
organisms |
T597 |
198-199 |
-LRB- |
denotes |
[ |
T598 |
199-200 |
CD |
denotes |
1 |
T599 |
200-201 |
-RRB- |
denotes |
] |
T600 |
201-203 |
, |
denotes |
, |
T601 |
203-206 |
PRP$ |
denotes |
its |
T602 |
207-216 |
NN |
denotes |
potential |
T603 |
217-219 |
TO |
denotes |
to |
T604 |
220-230 |
VB |
denotes |
contribute |
T605 |
231-233 |
IN |
denotes |
to |
T606 |
234-242 |
JJ |
denotes |
clinical |
T607 |
243-256 |
NN |
denotes |
heterogeneity |
T608 |
257-259 |
IN |
denotes |
in |
T609 |
260-265 |
JJ |
denotes |
human |
T610 |
266-273 |
NN |
denotes |
disease |
T611 |
274-276 |
VBZ |
denotes |
is |
T612 |
277-283 |
RB |
denotes |
seldom |
T590 |
284-294 |
VBN |
denotes |
considered |
T613 |
294-295 |
. |
denotes |
. |
T614 |
295-623 |
sentence |
denotes |
Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell-based studies of a handful of metabolic disorders with defects in enzymes including propinyl-CoA carboxylase [2], argininosuccinate lyase [3], galactose-1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5]. |
T615 |
296-304 |
NN |
denotes |
Evidence |
T617 |
305-307 |
IN |
denotes |
of |
T618 |
308-320 |
JJ |
denotes |
interallelic |
T619 |
321-336 |
NN |
denotes |
complementation |
T620 |
337-339 |
IN |
denotes |
at |
T621 |
340-350 |
RB |
denotes |
clinically |
T622 |
351-359 |
JJ |
denotes |
relevant |
T623 |
360-364 |
NNS |
denotes |
loci |
T624 |
365-367 |
VBZ |
denotes |
is |
T616 |
368-375 |
VBN |
denotes |
limited |
T625 |
376-378 |
IN |
denotes |
to |
T626 |
379-390 |
JJ |
denotes |
biochemical |
T628 |
391-394 |
CC |
denotes |
and |
T629 |
395-399 |
NN |
denotes |
cell |
T631 |
399-400 |
HYPH |
denotes |
- |
T630 |
400-405 |
VBN |
denotes |
based |
T627 |
406-413 |
NNS |
denotes |
studies |
T632 |
414-416 |
IN |
denotes |
of |
T633 |
417-418 |
DT |
denotes |
a |
T634 |
419-426 |
NN |
denotes |
handful |
T635 |
427-429 |
IN |
denotes |
of |
T636 |
430-439 |
JJ |
denotes |
metabolic |
T637 |
440-449 |
NNS |
denotes |
disorders |
T638 |
450-454 |
IN |
denotes |
with |
T639 |
455-462 |
NNS |
denotes |
defects |
T640 |
463-465 |
IN |
denotes |
in |
T641 |
466-473 |
NNS |
denotes |
enzymes |
T642 |
474-483 |
VBG |
denotes |
including |
T643 |
484-492 |
NN |
denotes |
propinyl |
T645 |
492-493 |
HYPH |
denotes |
- |
T644 |
493-496 |
NN |
denotes |
CoA |
T646 |
497-508 |
NN |
denotes |
carboxylase |
T647 |
509-510 |
-LRB- |
denotes |
[ |
T648 |
510-511 |
CD |
denotes |
2 |
T649 |
511-512 |
-RRB- |
denotes |
] |
T650 |
512-514 |
, |
denotes |
, |
T651 |
514-531 |
NN |
denotes |
argininosuccinate |
T652 |
532-537 |
NN |
denotes |
lyase |
T653 |
538-539 |
-LRB- |
denotes |
[ |
T654 |
539-540 |
CD |
denotes |
3 |
T655 |
540-541 |
-RRB- |
denotes |
] |
T656 |
541-543 |
, |
denotes |
, |
T657 |
543-552 |
NN |
denotes |
galactose |
T659 |
552-553 |
HYPH |
denotes |
- |
T660 |
553-554 |
CD |
denotes |
1 |
T661 |
554-555 |
HYPH |
denotes |
- |
T658 |
555-564 |
NN |
denotes |
phosphate |
T662 |
565-584 |
NN |
denotes |
uridylyltransferase |
T663 |
585-586 |
-LRB- |
denotes |
[ |
T664 |
586-587 |
CD |
denotes |
4 |
T665 |
587-588 |
-RRB- |
denotes |
] |
T666 |
588-590 |
, |
denotes |
, |
T667 |
590-593 |
CC |
denotes |
and |
T668 |
594-607 |
NN |
denotes |
methylmalonyl |
T670 |
608-611 |
NN |
denotes |
CoA |
T669 |
612-618 |
NN |
denotes |
mutase |
T671 |
619-620 |
-LRB- |
denotes |
[ |
T672 |
620-621 |
CD |
denotes |
5 |
T673 |
621-622 |
-RRB- |
denotes |
] |
T674 |
622-623 |
. |
denotes |
. |
R246 |
T565 |
T566 |
amod |
Interallelic,complementation |
R247 |
T566 |
T567 |
nsubjpass |
complementation,defined |
R248 |
T568 |
T567 |
auxpass |
is,defined |
R249 |
T569 |
T567 |
prep |
as,defined |
R250 |
T570 |
T571 |
det |
the,ability |
R251 |
T571 |
T569 |
pobj |
ability,as |
R252 |
T572 |
T571 |
prep |
of,ability |
R253 |
T573 |
T574 |
nummod |
two,alleles |
R254 |
T574 |
T572 |
pobj |
alleles,of |
R255 |
T575 |
T576 |
advmod |
differentially,mutated |
R256 |
T576 |
T574 |
amod |
mutated,alleles |
R257 |
T577 |
T578 |
aux |
to,function |
R258 |
T578 |
T571 |
acl |
function,ability |
R259 |
T579 |
T578 |
advmod |
better,function |
R260 |
T580 |
T578 |
advmod |
together,function |
R261 |
T581 |
T582 |
mark |
than,can |
R262 |
T582 |
T578 |
advcl |
can,function |
R263 |
T583 |
T582 |
nsubj |
either,can |
R264 |
T584 |
T582 |
prep |
on,can |
R265 |
T585 |
T586 |
poss |
its,own |
R266 |
T586 |
T584 |
pobj |
own,on |
R267 |
T587 |
T567 |
punct |
.,defined |
R268 |
T589 |
T590 |
prep |
Despite,considered |
R269 |
T591 |
T592 |
poss |
its,universality |
R270 |
T592 |
T589 |
pobj |
universality,Despite |
R271 |
T593 |
T592 |
amod |
near,universality |
R272 |
T594 |
T592 |
prep |
in,universality |
R273 |
T595 |
T596 |
amod |
lower,organisms |
R274 |
T596 |
T594 |
pobj |
organisms,in |
R275 |
T597 |
T598 |
punct |
[,1 |
R276 |
T598 |
T596 |
parataxis |
1,organisms |
R277 |
T599 |
T598 |
punct |
],1 |
R278 |
T600 |
T590 |
punct |
", ",considered |
R279 |
T601 |
T602 |
poss |
its,potential |
R280 |
T602 |
T590 |
nsubjpass |
potential,considered |
R281 |
T603 |
T604 |
aux |
to,contribute |
R282 |
T604 |
T602 |
acl |
contribute,potential |
R283 |
T605 |
T604 |
prep |
to,contribute |
R284 |
T606 |
T607 |
amod |
clinical,heterogeneity |
R285 |
T607 |
T605 |
pobj |
heterogeneity,to |
R286 |
T608 |
T607 |
prep |
in,heterogeneity |
R287 |
T609 |
T610 |
amod |
human,disease |
R288 |
T610 |
T608 |
pobj |
disease,in |
R289 |
T611 |
T590 |
auxpass |
is,considered |
R290 |
T612 |
T590 |
advmod |
seldom,considered |
R291 |
T613 |
T590 |
punct |
.,considered |
R292 |
T615 |
T616 |
nsubjpass |
Evidence,limited |
R293 |
T617 |
T615 |
prep |
of,Evidence |
R294 |
T618 |
T619 |
amod |
interallelic,complementation |
R295 |
T619 |
T617 |
pobj |
complementation,of |
R296 |
T620 |
T619 |
prep |
at,complementation |
R297 |
T621 |
T622 |
advmod |
clinically,relevant |
R298 |
T622 |
T623 |
amod |
relevant,loci |
R299 |
T623 |
T620 |
pobj |
loci,at |
R300 |
T624 |
T616 |
auxpass |
is,limited |
R301 |
T625 |
T616 |
prep |
to,limited |
R302 |
T626 |
T627 |
amod |
biochemical,studies |
R303 |
T627 |
T625 |
pobj |
studies,to |
R304 |
T628 |
T626 |
cc |
and,biochemical |
R305 |
T629 |
T630 |
npadvmod |
cell,based |
R306 |
T630 |
T626 |
conj |
based,biochemical |
R307 |
T631 |
T630 |
punct |
-,based |
R308 |
T632 |
T627 |
prep |
of,studies |
R309 |
T633 |
T634 |
det |
a,handful |
R310 |
T634 |
T632 |
pobj |
handful,of |
R311 |
T635 |
T634 |
prep |
of,handful |
R312 |
T636 |
T637 |
amod |
metabolic,disorders |
R313 |
T637 |
T635 |
pobj |
disorders,of |
R314 |
T638 |
T637 |
prep |
with,disorders |
R315 |
T639 |
T638 |
pobj |
defects,with |
R316 |
T640 |
T639 |
prep |
in,defects |
R317 |
T641 |
T640 |
pobj |
enzymes,in |
R318 |
T642 |
T641 |
prep |
including,enzymes |
R319 |
T643 |
T644 |
compound |
propinyl,CoA |
R320 |
T644 |
T646 |
compound |
CoA,carboxylase |
R321 |
T645 |
T644 |
punct |
-,CoA |
R322 |
T646 |
T642 |
pobj |
carboxylase,including |
R323 |
T647 |
T648 |
punct |
[,2 |
R324 |
T648 |
T646 |
parataxis |
2,carboxylase |
R325 |
T649 |
T648 |
punct |
],2 |
R326 |
T650 |
T646 |
punct |
", ",carboxylase |
R327 |
T651 |
T652 |
compound |
argininosuccinate,lyase |
R328 |
T652 |
T646 |
conj |
lyase,carboxylase |
R329 |
T653 |
T654 |
punct |
[,3 |
R330 |
T654 |
T652 |
parataxis |
3,lyase |
R331 |
T655 |
T654 |
punct |
],3 |
R332 |
T656 |
T652 |
punct |
", ",lyase |
R333 |
T657 |
T658 |
nmod |
galactose,phosphate |
R334 |
T658 |
T662 |
compound |
phosphate,uridylyltransferase |
R335 |
T659 |
T658 |
punct |
-,phosphate |
R336 |
T660 |
T658 |
nummod |
1,phosphate |
R337 |
T661 |
T658 |
punct |
-,phosphate |
R338 |
T662 |
T652 |
conj |
uridylyltransferase,lyase |
R339 |
T663 |
T664 |
punct |
[,4 |
R340 |
T664 |
T662 |
parataxis |
4,uridylyltransferase |
R341 |
T665 |
T664 |
punct |
],4 |
R342 |
T666 |
T662 |
punct |
", ",uridylyltransferase |
R343 |
T667 |
T662 |
cc |
and,uridylyltransferase |
R344 |
T668 |
T669 |
compound |
methylmalonyl,mutase |
R345 |
T669 |
T662 |
conj |
mutase,uridylyltransferase |
R346 |
T670 |
T669 |
compound |
CoA,mutase |
R347 |
T671 |
T672 |
punct |
[,5 |
R348 |
T672 |
T669 |
parataxis |
5,mutase |
R349 |
T673 |
T672 |
punct |
],5 |
R350 |
T674 |
T616 |
punct |
.,limited |