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PMC:1584416 / 1887-36162 JSONTXT 5 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T565 13-25 JJ denotes Interallelic
T566 26-41 NN denotes complementation
T568 42-44 VBZ denotes is
T567 45-52 VBN denotes defined
T569 53-55 IN denotes as
T570 56-59 DT denotes the
T571 60-67 NN denotes ability
T572 68-70 IN denotes of
T573 71-74 CD denotes two
T575 75-89 RB denotes differentially
T576 90-97 VBN denotes mutated
T574 98-105 NNS denotes alleles
T577 106-108 TO denotes to
T578 109-117 VB denotes function
T579 118-124 RBR denotes better
T580 125-133 RB denotes together
T581 134-138 IN denotes than
T583 139-145 DT denotes either
T582 146-149 MD denotes can
T584 150-152 IN denotes on
T585 153-156 PRP$ denotes its
T586 157-160 JJ denotes own
T587 160-161 . denotes .
T588 161-308 sentence denotes Despite its near universality in lower organisms [1], its potential to contribute to clinical heterogeneity in human disease is seldom considered.
T589 162-169 IN denotes Despite
T591 170-173 PRP$ denotes its
T593 174-178 JJ denotes near
T592 179-191 NN denotes universality
T594 192-194 IN denotes in
T595 195-200 JJR denotes lower
T596 201-210 NNS denotes organisms
T597 211-212 -LRB- denotes [
T598 212-213 CD denotes 1
T599 213-214 -RRB- denotes ]
T600 214-216 , denotes ,
T601 216-219 PRP$ denotes its
T602 220-229 NN denotes potential
T603 230-232 TO denotes to
T604 233-243 VB denotes contribute
T605 244-246 IN denotes to
T606 247-255 JJ denotes clinical
T607 256-269 NN denotes heterogeneity
T608 270-272 IN denotes in
T609 273-278 JJ denotes human
T610 279-286 NN denotes disease
T611 287-289 VBZ denotes is
T612 290-296 RB denotes seldom
T590 297-307 VBN denotes considered
T613 307-308 . denotes .
T614 308-636 sentence denotes Evidence of interallelic complementation at clinically relevant loci is limited to biochemical and cell-based studies of a handful of metabolic disorders with defects in enzymes including propinyl-CoA carboxylase [2], argininosuccinate lyase [3], galactose-1-phosphate uridylyltransferase [4], and methylmalonyl CoA mutase [5].
T615 309-317 NN denotes Evidence
T617 318-320 IN denotes of
T618 321-333 JJ denotes interallelic
T619 334-349 NN denotes complementation
T620 350-352 IN denotes at
T621 353-363 RB denotes clinically
T622 364-372 JJ denotes relevant
T623 373-377 NNS denotes loci
T624 378-380 VBZ denotes is
T616 381-388 VBN denotes limited
T625 389-391 IN denotes to
T626 392-403 JJ denotes biochemical
T628 404-407 CC denotes and
T629 408-412 NN denotes cell
T631 412-413 HYPH denotes -
T630 413-418 VBN denotes based
T627 419-426 NNS denotes studies
T632 427-429 IN denotes of
T633 430-431 DT denotes a
T634 432-439 NN denotes handful
T635 440-442 IN denotes of
T636 443-452 JJ denotes metabolic
T637 453-462 NNS denotes disorders
T638 463-467 IN denotes with
T639 468-475 NNS denotes defects
T640 476-478 IN denotes in
T641 479-486 NNS denotes enzymes
T642 487-496 VBG denotes including
T643 497-505 NN denotes propinyl
T645 505-506 HYPH denotes -
T644 506-509 NN denotes CoA
T646 510-521 NN denotes carboxylase
T647 522-523 -LRB- denotes [
T648 523-524 CD denotes 2
T649 524-525 -RRB- denotes ]
T650 525-527 , denotes ,
T651 527-544 NN denotes argininosuccinate
T652 545-550 NN denotes lyase
T653 551-552 -LRB- denotes [
T654 552-553 CD denotes 3
T655 553-554 -RRB- denotes ]
T656 554-556 , denotes ,
T657 556-565 NN denotes galactose
T659 565-566 HYPH denotes -
T660 566-567 CD denotes 1
T661 567-568 HYPH denotes -
T658 568-577 NN denotes phosphate
T662 578-597 NN denotes uridylyltransferase
T663 598-599 -LRB- denotes [
T664 599-600 CD denotes 4
T665 600-601 -RRB- denotes ]
T666 601-603 , denotes ,
T667 603-606 CC denotes and
T668 607-620 NN denotes methylmalonyl
T670 621-624 NN denotes CoA
T669 625-631 NN denotes mutase
T671 632-633 -LRB- denotes [
T672 633-634 CD denotes 5
T673 634-635 -RRB- denotes ]
T674 635-636 . denotes .
T675 636-731 sentence denotes Compound heterozygotes are individuals carrying two different mutant alleles of the same gene.
T676 637-645 JJ denotes Compound
T677 646-659 NNS denotes heterozygotes
T678 660-663 VBP denotes are
T679 664-675 NNS denotes individuals
T680 676-684 VBG denotes carrying
T681 685-688 CD denotes two
T683 689-698 JJ denotes different
T684 699-705 JJ denotes mutant
T682 706-713 NNS denotes alleles
T685 714-716 IN denotes of
T686 717-720 DT denotes the
T688 721-725 JJ denotes same
T687 726-730 NN denotes gene
T689 730-731 . denotes .
T690 731-960 sentence denotes In the absence of a dominant (wild-type [wt]) allele, genetic interactions between recessive alleles (referred to here as “biallelic” effects) could result in different phenotypic outcomes including interallelic complementation.
T691 732-734 IN denotes In
T693 735-738 DT denotes the
T694 739-746 NN denotes absence
T695 747-749 IN denotes of
T696 750-751 DT denotes a
T698 752-760 JJ denotes dominant
T699 761-762 -LRB- denotes (
T700 762-766 JJ denotes wild
T702 766-767 HYPH denotes -
T701 767-771 NN denotes type
T703 772-773 -LRB- denotes [
T704 773-775 NN denotes wt
T705 775-776 -RRB- denotes ]
T706 776-777 -RRB- denotes )
T697 778-784 NN denotes allele
T707 784-786 , denotes ,
T708 786-793 JJ denotes genetic
T709 794-806 NNS denotes interactions
T710 807-814 IN denotes between
T711 815-824 JJ denotes recessive
T712 825-832 NNS denotes alleles
T713 833-834 -LRB- denotes (
T714 834-842 VBN denotes referred
T715 843-845 IN denotes to
T716 846-850 RB denotes here
T717 851-853 IN denotes as
T718 854-855 `` denotes “
T719 855-864 JJ denotes biallelic
T721 864-865 '' denotes ”
T720 866-873 NNS denotes effects
T722 873-874 -RRB- denotes )
T723 875-880 MD denotes could
T692 881-887 VB denotes result
T724 888-890 IN denotes in
T725 891-900 JJ denotes different
T727 901-911 JJ denotes phenotypic
T726 912-920 NNS denotes outcomes
T728 921-930 VBG denotes including
T729 931-943 JJ denotes interallelic
T730 944-959 NN denotes complementation
T731 959-960 . denotes .
T732 960-1296 sentence denotes Although amelioration of disease symptoms by interallelic complementation would create an ascertainment bias in the clinic, the lack of evidence concerning interallelic complementation or other biallelic effects in human disease is likely caused by the difficulty in distinguishing such effects from environment and genetic background.
T733 961-969 IN denotes Although
T735 970-982 NN denotes amelioration
T736 983-985 IN denotes of
T737 986-993 NN denotes disease
T738 994-1002 NNS denotes symptoms
T739 1003-1005 IN denotes by
T740 1006-1018 JJ denotes interallelic
T741 1019-1034 NN denotes complementation
T742 1035-1040 MD denotes would
T734 1041-1047 VB denotes create
T744 1048-1050 DT denotes an
T746 1051-1064 NN denotes ascertainment
T745 1065-1069 NN denotes bias
T747 1070-1072 IN denotes in
T748 1073-1076 DT denotes the
T749 1077-1083 NN denotes clinic
T750 1083-1085 , denotes ,
T751 1085-1088 DT denotes the
T752 1089-1093 NN denotes lack
T753 1094-1096 IN denotes of
T754 1097-1105 NN denotes evidence
T755 1106-1116 VBG denotes concerning
T756 1117-1129 JJ denotes interallelic
T757 1130-1145 NN denotes complementation
T758 1146-1148 CC denotes or
T759 1149-1154 JJ denotes other
T761 1155-1164 JJ denotes biallelic
T760 1165-1172 NNS denotes effects
T762 1173-1175 IN denotes in
T763 1176-1181 JJ denotes human
T764 1182-1189 NN denotes disease
T765 1190-1192 VBZ denotes is
T766 1193-1199 RB denotes likely
T743 1200-1206 VBN denotes caused
T767 1207-1209 IN denotes by
T768 1210-1213 DT denotes the
T769 1214-1224 NN denotes difficulty
T770 1225-1227 IN denotes in
T771 1228-1242 VBG denotes distinguishing
T772 1243-1247 JJ denotes such
T773 1248-1255 NNS denotes effects
T774 1256-1260 IN denotes from
T775 1261-1272 NN denotes environment
T776 1273-1276 CC denotes and
T777 1277-1284 JJ denotes genetic
T778 1285-1295 NN denotes background
T779 1295-1296 . denotes .
T780 1296-1597 sentence denotes XPD encodes one of the two helicase components of basal transcription/DNA repair factor IIH (TFIIH), a ten-subunit, multifunctional complex that is essential for multiple processes, including basal transcription initiation and DNA damage repair via the nucleotide excision repair (NER) pathway [6,7].
T781 1297-1300 NN denotes XPD
T782 1301-1308 VBZ denotes encodes
T783 1309-1312 CD denotes one
T784 1313-1315 IN denotes of
T785 1316-1319 DT denotes the
T787 1320-1323 CD denotes two
T788 1324-1332 NN denotes helicase
T786 1333-1343 NNS denotes components
T789 1344-1346 IN denotes of
T790 1347-1352 JJ denotes basal
T792 1353-1366 NN denotes transcription
T793 1366-1367 HYPH denotes /
T794 1367-1370 NN denotes DNA
T795 1371-1377 NN denotes repair
T796 1378-1384 NN denotes factor
T791 1385-1388 NN denotes IIH
T797 1389-1390 -LRB- denotes (
T798 1390-1395 NN denotes TFIIH
T799 1395-1396 -RRB- denotes )
T800 1396-1398 , denotes ,
T801 1398-1399 DT denotes a
T803 1400-1403 CD denotes ten
T805 1403-1404 HYPH denotes -
T804 1404-1411 NN denotes subunit
T806 1411-1413 , denotes ,
T807 1413-1428 JJ denotes multifunctional
T802 1429-1436 NN denotes complex
T808 1437-1441 WDT denotes that
T809 1442-1444 VBZ denotes is
T810 1445-1454 JJ denotes essential
T811 1455-1458 IN denotes for
T812 1459-1467 JJ denotes multiple
T813 1468-1477 NNS denotes processes
T814 1477-1479 , denotes ,
T815 1479-1488 VBG denotes including
T816 1489-1494 JJ denotes basal
T818 1495-1508 NN denotes transcription
T817 1509-1519 NN denotes initiation
T819 1520-1523 CC denotes and
T820 1524-1527 NN denotes DNA
T822 1528-1534 NN denotes damage
T821 1535-1541 NN denotes repair
T823 1542-1545 IN denotes via
T824 1546-1549 DT denotes the
T826 1550-1560 NN denotes nucleotide
T828 1561-1569 NN denotes excision
T827 1570-1576 NN denotes repair
T829 1577-1578 -LRB- denotes (
T830 1578-1581 NN denotes NER
T831 1581-1582 -RRB- denotes )
T825 1583-1590 NN denotes pathway
T832 1591-1592 -LRB- denotes [
T834 1592-1593 CD denotes 6
T835 1593-1594 , denotes ,
T833 1594-1595 CD denotes 7
T836 1595-1596 -RRB- denotes ]
T837 1596-1597 . denotes .
T838 1597-1827 sentence denotes Alterations in XPD resulting in defective TFIIH function are associated with UV-sensitive, multisystem disorders including xeroderma pigmentosum (XP), XP combined with Cockayne syndrome (CS), and trichothiodystrophy (TTD) [8–10].
T839 1598-1609 NNS denotes Alterations
T841 1610-1612 IN denotes in
T842 1613-1616 NN denotes XPD
T843 1617-1626 VBG denotes resulting
T844 1627-1629 IN denotes in
T845 1630-1639 JJ denotes defective
T847 1640-1645 NN denotes TFIIH
T846 1646-1654 NN denotes function
T848 1655-1658 VBP denotes are
T840 1659-1669 VBN denotes associated
T849 1670-1674 IN denotes with
T850 1675-1677 NN denotes UV
T852 1677-1678 HYPH denotes -
T851 1678-1687 JJ denotes sensitive
T854 1687-1689 , denotes ,
T855 1689-1700 JJ denotes multisystem
T853 1701-1710 NNS denotes disorders
T856 1711-1720 VBG denotes including
T857 1721-1730 NN denotes xeroderma
T858 1731-1742 NN denotes pigmentosum
T859 1743-1744 -LRB- denotes (
T860 1744-1746 NN denotes XP
T861 1746-1747 -RRB- denotes )
T862 1747-1749 , denotes ,
T863 1749-1751 NN denotes XP
T864 1752-1760 VBN denotes combined
T865 1761-1765 IN denotes with
T866 1766-1774 NN denotes Cockayne
T867 1775-1783 NN denotes syndrome
T868 1784-1785 -LRB- denotes (
T869 1785-1787 NN denotes CS
T870 1787-1788 -RRB- denotes )
T871 1788-1790 , denotes ,
T872 1790-1793 CC denotes and
T873 1794-1813 NN denotes trichothiodystrophy
T874 1814-1815 -LRB- denotes (
T875 1815-1818 NN denotes TTD
T876 1818-1819 -RRB- denotes )
T877 1820-1821 -LRB- denotes [
T878 1821-1822 CD denotes 8
T879 1822-1823 SYM denotes –
T880 1823-1825 CD denotes 10
T881 1825-1826 -RRB- denotes ]
T882 1826-1827 . denotes .
T883 1827-1939 sentence denotes XP is marked by sun-induced pigmentation anomalies and a greater than 1,000-fold elevation in skin cancer risk.
T884 1828-1830 NN denotes XP
T886 1831-1833 VBZ denotes is
T885 1834-1840 VBN denotes marked
T887 1841-1843 IN denotes by
T888 1844-1847 NN denotes sun
T890 1847-1848 HYPH denotes -
T889 1848-1855 VBN denotes induced
T892 1856-1868 NN denotes pigmentation
T891 1869-1878 NNS denotes anomalies
T893 1879-1882 CC denotes and
T894 1883-1884 DT denotes a
T896 1885-1892 JJR denotes greater
T898 1893-1897 IN denotes than
T897 1898-1903 CD denotes 1,000
T900 1903-1904 HYPH denotes -
T899 1904-1908 RB denotes fold
T895 1909-1918 NN denotes elevation
T901 1919-1921 IN denotes in
T902 1922-1926 NN denotes skin
T903 1927-1933 NN denotes cancer
T904 1934-1938 NN denotes risk
T905 1938-1939 . denotes .
T906 1939-2029 sentence denotes Severe cases can also present with growth retardation and primary neurodegeneration [11].
T907 1940-1946 JJ denotes Severe
T908 1947-1952 NNS denotes cases
T910 1953-1956 MD denotes can
T911 1957-1961 RB denotes also
T909 1962-1969 VB denotes present
T912 1970-1974 IN denotes with
T913 1975-1981 NN denotes growth
T914 1982-1993 NN denotes retardation
T915 1994-1997 CC denotes and
T916 1998-2005 JJ denotes primary
T917 2006-2023 NN denotes neurodegeneration
T918 2024-2025 -LRB- denotes [
T919 2025-2027 CD denotes 11
T920 2027-2028 -RRB- denotes ]
T921 2028-2029 . denotes .
T922 2029-2264 sentence denotes CS and TTD, on the other hand, are segmental progeroid disorders characterised by progressive post-natal growth failure and primary demyelination resulting in severe neurodysfunction, but without a clear cancer predisposition [12–15].
T923 2030-2032 NN denotes CS
T925 2033-2036 CC denotes and
T926 2037-2040 NN denotes TTD
T927 2040-2042 , denotes ,
T928 2042-2044 IN denotes on
T929 2045-2048 DT denotes the
T931 2049-2054 JJ denotes other
T930 2055-2059 NN denotes hand
T932 2059-2061 , denotes ,
T924 2061-2064 VBP denotes are
T933 2065-2074 JJ denotes segmental
T935 2075-2084 JJ denotes progeroid
T934 2085-2094 NNS denotes disorders
T936 2095-2108 VBN denotes characterised
T937 2109-2111 IN denotes by
T938 2112-2123 JJ denotes progressive
T940 2124-2134 JJ denotes post-natal
T941 2135-2141 NN denotes growth
T939 2142-2149 NN denotes failure
T942 2150-2153 CC denotes and
T943 2154-2161 JJ denotes primary
T944 2162-2175 NN denotes demyelination
T945 2176-2185 VBG denotes resulting
T946 2186-2188 IN denotes in
T947 2189-2195 JJ denotes severe
T948 2196-2212 NN denotes neurodysfunction
T949 2212-2214 , denotes ,
T950 2214-2217 CC denotes but
T951 2218-2225 IN denotes without
T952 2226-2227 DT denotes a
T954 2228-2233 JJ denotes clear
T955 2234-2240 NN denotes cancer
T953 2241-2255 NN denotes predisposition
T956 2256-2257 -LRB- denotes [
T957 2257-2259 CD denotes 12
T958 2259-2260 SYM denotes –
T959 2260-2262 CD denotes 15
T960 2262-2263 -RRB- denotes ]
T961 2263-2264 . denotes .
T962 2264-2452 sentence denotes Patients with TTD additionally display hallmark sulphur-deficient brittle hair and nails and scaling skin [13], resulting from a basal transcription defect in specific cell types [16,17].
T963 2265-2273 NNS denotes Patients
T965 2274-2278 IN denotes with
T966 2279-2282 NN denotes TTD
T967 2283-2295 RB denotes additionally
T964 2296-2303 VBP denotes display
T968 2304-2312 NN denotes hallmark
T970 2313-2320 NN denotes sulphur
T972 2320-2321 HYPH denotes -
T971 2321-2330 JJ denotes deficient
T973 2331-2338 JJ denotes brittle
T969 2339-2343 NN denotes hair
T974 2344-2347 CC denotes and
T975 2348-2353 NNS denotes nails
T976 2354-2357 CC denotes and
T977 2358-2365 JJ denotes scaling
T978 2366-2370 NN denotes skin
T979 2371-2372 -LRB- denotes [
T980 2372-2374 CD denotes 13
T981 2374-2375 -RRB- denotes ]
T982 2375-2377 , denotes ,
T983 2377-2386 VBG denotes resulting
T984 2387-2391 IN denotes from
T985 2392-2393 DT denotes a
T987 2394-2399 JJ denotes basal
T988 2400-2413 NN denotes transcription
T986 2414-2420 NN denotes defect
T989 2421-2423 IN denotes in
T990 2424-2432 JJ denotes specific
T992 2433-2437 NN denotes cell
T991 2438-2443 NNS denotes types
T993 2444-2445 -LRB- denotes [
T995 2445-2447 CD denotes 16
T996 2447-2448 , denotes ,
T994 2448-2450 CD denotes 17
T997 2450-2451 -RRB- denotes ]
T998 2451-2452 . denotes .
T999 2452-2618 sentence denotes A related disorder with the cancer predisposition of XP combined with the neurodevelopmental complications of CS (XPCS), although rare, has also been described [18].
T1000 2453-2454 DT denotes A
T1002 2455-2462 JJ denotes related
T1001 2463-2471 NN denotes disorder
T1004 2472-2476 IN denotes with
T1005 2477-2480 DT denotes the
T1007 2481-2487 NN denotes cancer
T1006 2488-2502 NN denotes predisposition
T1008 2503-2505 IN denotes of
T1009 2506-2508 NN denotes XP
T1010 2509-2517 VBN denotes combined
T1011 2518-2522 IN denotes with
T1012 2523-2526 DT denotes the
T1014 2527-2545 JJ denotes neurodevelopmental
T1013 2546-2559 NNS denotes complications
T1015 2560-2562 IN denotes of
T1016 2563-2565 NN denotes CS
T1017 2566-2567 -LRB- denotes (
T1018 2567-2571 NN denotes XPCS
T1019 2571-2572 -RRB- denotes )
T1020 2572-2574 , denotes ,
T1021 2574-2582 IN denotes although
T1022 2583-2587 JJ denotes rare
T1023 2587-2589 , denotes ,
T1024 2589-2592 VBZ denotes has
T1025 2593-2597 RB denotes also
T1026 2598-2602 VBN denotes been
T1003 2603-2612 VBN denotes described
T1027 2613-2614 -LRB- denotes [
T1028 2614-2616 CD denotes 18
T1029 2616-2617 -RRB- denotes ]
T1030 2617-2618 . denotes .
T1031 2618-2800 sentence denotes Many XPD mutations are associated with an exclusive disease phenotype (e.g., XPDR722W with TTD and XPDR683W with XP) and are thus viewed as causative of the corresponding syndromes.
T1032 2619-2623 JJ denotes Many
T1034 2624-2627 NN denotes XPD
T1033 2628-2637 NNS denotes mutations
T1036 2638-2641 VBP denotes are
T1035 2642-2652 VBN denotes associated
T1037 2653-2657 IN denotes with
T1038 2658-2660 DT denotes an
T1040 2661-2670 JJ denotes exclusive
T1041 2671-2678 NN denotes disease
T1039 2679-2688 NN denotes phenotype
T1042 2689-2690 -LRB- denotes (
T1044 2690-2694 FW denotes e.g.
T1045 2694-2696 , denotes ,
T1043 2696-2704 NN denotes XPDR722W
T1046 2705-2709 IN denotes with
T1047 2710-2713 NN denotes TTD
T1048 2714-2717 CC denotes and
T1049 2718-2726 NN denotes XPDR683W
T1050 2727-2731 IN denotes with
T1051 2732-2734 NN denotes XP
T1052 2734-2735 -RRB- denotes )
T1053 2736-2739 CC denotes and
T1054 2740-2743 VBP denotes are
T1056 2744-2748 RB denotes thus
T1055 2749-2755 VBN denotes viewed
T1057 2756-2758 IN denotes as
T1058 2759-2768 JJ denotes causative
T1059 2769-2771 IN denotes of
T1060 2772-2775 DT denotes the
T1062 2776-2789 VBG denotes corresponding
T1061 2790-2799 NNS denotes syndromes
T1063 2799-2800 . denotes .
T1064 2800-2899 sentence denotes Alleles not associated exclusively with one disorder are considered “likely null” alleles [19,20].
T1065 2801-2808 NNS denotes Alleles
T1067 2809-2812 RB denotes not
T1068 2813-2823 VBN denotes associated
T1069 2824-2835 RB denotes exclusively
T1070 2836-2840 IN denotes with
T1071 2841-2844 CD denotes one
T1072 2845-2853 NN denotes disorder
T1073 2854-2857 VBP denotes are
T1066 2858-2868 VBN denotes considered
T1074 2869-2870 `` denotes “
T1076 2870-2876 RB denotes likely
T1077 2877-2881 JJ denotes null
T1078 2881-2882 '' denotes ”
T1075 2883-2890 NNS denotes alleles
T1079 2891-2892 -LRB- denotes [
T1081 2892-2894 CD denotes 19
T1082 2894-2895 , denotes ,
T1080 2895-2897 CD denotes 20
T1083 2897-2898 -RRB- denotes ]
T1084 2898-2899 . denotes .
T1085 2899-3119 sentence denotes Some of these alleles fail to support viability in a haploid Schizosaccharomyces pombe yeast strain with a null mutation in the XPD homologue rad15 and are thus considered devoid of significant biological activity [19].
T1086 2900-2904 DT denotes Some
T1088 2905-2907 IN denotes of
T1089 2908-2913 DT denotes these
T1090 2914-2921 NNS denotes alleles
T1087 2922-2926 VBP denotes fail
T1091 2927-2929 TO denotes to
T1092 2930-2937 VB denotes support
T1093 2938-2947 NN denotes viability
T1094 2948-2950 IN denotes in
T1095 2951-2952 DT denotes a
T1097 2953-2960 JJ denotes haploid
T1098 2961-2980 NNP denotes Schizosaccharomyces
T1099 2981-2986 NNP denotes pombe
T1100 2987-2992 NN denotes yeast
T1096 2993-2999 NN denotes strain
T1101 3000-3004 IN denotes with
T1102 3005-3006 DT denotes a
T1104 3007-3011 JJ denotes null
T1103 3012-3020 NN denotes mutation
T1105 3021-3023 IN denotes in
T1106 3024-3027 DT denotes the
T1108 3028-3031 NN denotes XPD
T1109 3032-3041 NN denotes homologue
T1107 3042-3047 NN denotes rad15
T1110 3048-3051 CC denotes and
T1111 3052-3055 VBP denotes are
T1113 3056-3060 RB denotes thus
T1112 3061-3071 VBN denotes considered
T1114 3072-3078 JJ denotes devoid
T1115 3079-3081 IN denotes of
T1116 3082-3093 JJ denotes significant
T1118 3094-3104 JJ denotes biological
T1117 3105-3113 NN denotes activity
T1119 3114-3115 -LRB- denotes [
T1120 3115-3117 CD denotes 19
T1121 3117-3118 -RRB- denotes ]
T1122 3118-3119 . denotes .
T1123 3119-3257 sentence denotes This classification of alleles as either causative or null currently defines what we refer to as a “monoallelic” paradigm of XPD disease.
T1124 3120-3124 DT denotes This
T1125 3125-3139 NN denotes classification
T1127 3140-3142 IN denotes of
T1128 3143-3150 NNS denotes alleles
T1129 3151-3153 IN denotes as
T1130 3154-3160 CC denotes either
T1131 3161-3170 JJ denotes causative
T1132 3171-3173 CC denotes or
T1133 3174-3178 JJ denotes null
T1134 3179-3188 RB denotes currently
T1126 3189-3196 VBZ denotes defines
T1135 3197-3201 WP denotes what
T1137 3202-3204 PRP denotes we
T1136 3205-3210 VBP denotes refer
T1138 3211-3213 IN denotes to
T1139 3214-3216 IN denotes as
T1140 3217-3218 DT denotes a
T1142 3219-3220 `` denotes “
T1143 3220-3231 JJ denotes monoallelic
T1144 3231-3232 '' denotes ”
T1141 3233-3241 NN denotes paradigm
T1145 3242-3244 IN denotes of
T1146 3245-3248 NN denotes XPD
T1147 3249-3256 NN denotes disease
T1148 3256-3257 . denotes .
T1149 3257-3538 sentence denotes However, the identification in recent years of XP complementation group D patients with atypical disease presentation, including symptoms of both XP and TTD [8], casts doubt on the ability of such a monoallelic paradigm to explain clinical heterogeneity in compound heterozygotes.
T1150 3258-3265 RB denotes However
T1152 3265-3267 , denotes ,
T1153 3267-3270 DT denotes the
T1154 3271-3285 NN denotes identification
T1155 3286-3288 IN denotes in
T1156 3289-3295 JJ denotes recent
T1157 3296-3301 NNS denotes years
T1158 3302-3304 IN denotes of
T1159 3305-3307 NN denotes XP
T1161 3308-3323 NN denotes complementation
T1162 3324-3329 NN denotes group
T1163 3330-3331 NN denotes D
T1160 3332-3340 NNS denotes patients
T1164 3341-3345 IN denotes with
T1165 3346-3354 JJ denotes atypical
T1167 3355-3362 NN denotes disease
T1166 3363-3375 NN denotes presentation
T1168 3375-3377 , denotes ,
T1169 3377-3386 VBG denotes including
T1170 3387-3395 NNS denotes symptoms
T1171 3396-3398 IN denotes of
T1172 3399-3403 CC denotes both
T1173 3404-3406 NN denotes XP
T1174 3407-3410 CC denotes and
T1175 3411-3414 NN denotes TTD
T1176 3415-3416 -LRB- denotes [
T1177 3416-3417 CD denotes 8
T1178 3417-3418 -RRB- denotes ]
T1179 3418-3420 , denotes ,
T1151 3420-3425 VBZ denotes casts
T1180 3426-3431 NN denotes doubt
T1181 3432-3434 IN denotes on
T1182 3435-3438 DT denotes the
T1183 3439-3446 NN denotes ability
T1184 3447-3449 IN denotes of
T1185 3450-3454 JJ denotes such
T1187 3455-3456 DT denotes a
T1188 3457-3468 JJ denotes monoallelic
T1186 3469-3477 NN denotes paradigm
T1189 3478-3480 TO denotes to
T1190 3481-3488 VB denotes explain
T1191 3489-3497 JJ denotes clinical
T1192 3498-3511 NN denotes heterogeneity
T1193 3512-3514 IN denotes in
T1194 3515-3523 NN denotes compound
T1195 3524-3537 NNS denotes heterozygotes
T1196 3537-3538 . denotes .
T1197 3538-3637 sentence denotes Previously, we generated a TTD mouse model (XPDR722W) that phenocopies the human syndrome [15,21].
T1198 3539-3549 RB denotes Previously
T1200 3549-3551 , denotes ,
T1201 3551-3553 PRP denotes we
T1199 3554-3563 VBD denotes generated
T1202 3564-3565 DT denotes a
T1204 3566-3569 NN denotes TTD
T1205 3570-3575 NN denotes mouse
T1203 3576-3581 NN denotes model
T1206 3582-3583 -LRB- denotes (
T1207 3583-3591 NN denotes XPDR722W
T1208 3591-3592 -RRB- denotes )
T1209 3593-3597 WDT denotes that
T1210 3598-3609 VBZ denotes phenocopies
T1211 3610-3613 DT denotes the
T1213 3614-3619 JJ denotes human
T1212 3620-3628 NN denotes syndrome
T1214 3629-3630 -LRB- denotes [
T1216 3630-3632 CD denotes 15
T1217 3632-3633 , denotes ,
T1215 3633-3635 CD denotes 21
T1218 3635-3636 -RRB- denotes ]
T1219 3636-3637 . denotes .
T1220 3637-3928 sentence denotes Here we report the generation of additional mutant Xpd alleles that fail to support viability on their own but nevertheless ameliorate TTD-associated premature segmental ageing, cutaneous features, cellular DNA repair capacity, and UV survival when present in a compound heterozygote state.
T1221 3638-3642 RB denotes Here
T1223 3643-3645 PRP denotes we
T1222 3646-3652 VBP denotes report
T1224 3653-3656 DT denotes the
T1225 3657-3667 NN denotes generation
T1226 3668-3670 IN denotes of
T1227 3671-3681 JJ denotes additional
T1229 3682-3688 JJ denotes mutant
T1230 3689-3692 NN denotes Xpd
T1228 3693-3700 NNS denotes alleles
T1231 3701-3705 WDT denotes that
T1232 3706-3710 VBP denotes fail
T1233 3711-3713 TO denotes to
T1234 3714-3721 VB denotes support
T1235 3722-3731 NN denotes viability
T1236 3732-3734 IN denotes on
T1237 3735-3740 PRP$ denotes their
T1238 3741-3744 NN denotes own
T1239 3745-3748 CC denotes but
T1240 3749-3761 RB denotes nevertheless
T1241 3762-3772 VBP denotes ameliorate
T1242 3773-3776 NN denotes TTD
T1244 3776-3777 HYPH denotes -
T1243 3777-3787 VBN denotes associated
T1246 3788-3797 JJ denotes premature
T1247 3798-3807 JJ denotes segmental
T1245 3808-3814 NN denotes ageing
T1248 3814-3816 , denotes ,
T1249 3816-3825 JJ denotes cutaneous
T1250 3826-3834 NNS denotes features
T1251 3834-3836 , denotes ,
T1252 3836-3844 JJ denotes cellular
T1254 3845-3848 NN denotes DNA
T1255 3849-3855 NN denotes repair
T1253 3856-3864 NN denotes capacity
T1256 3864-3866 , denotes ,
T1257 3866-3869 CC denotes and
T1258 3870-3872 NN denotes UV
T1259 3873-3881 NN denotes survival
T1260 3882-3886 WRB denotes when
T1261 3887-3894 JJ denotes present
T1262 3895-3897 IN denotes in
T1263 3898-3899 DT denotes a
T1265 3900-3908 JJ denotes compound
T1266 3909-3921 NN denotes heterozygote
T1264 3922-3927 NN denotes state
T1267 3927-3928 . denotes .
T1400 3939-3949 NN denotes Generation
T1401 3950-3952 IN denotes of
T1402 3953-3956 NN denotes Xpd
T1404 3957-3965 NN denotes Compound
T1403 3966-3979 NNS denotes Heterozygotes
T1405 3979-4132 sentence denotes We generated an Xpd knock-in allele with a point mutation encoding a single amino acid change (XPDG602D) found in the XPCS patient XPCS2 (Figure 1A–1C).
T1406 3980-3982 PRP denotes We
T1407 3983-3992 VBD denotes generated
T1408 3993-3995 DT denotes an
T1410 3996-3999 NN denotes Xpd
T1411 4000-4005 VB denotes knock
T1412 4005-4006 HYPH denotes -
T1413 4006-4008 RP denotes in
T1409 4009-4015 NN denotes allele
T1414 4016-4020 IN denotes with
T1415 4021-4022 DT denotes a
T1417 4023-4028 NN denotes point
T1416 4029-4037 NN denotes mutation
T1418 4038-4046 VBG denotes encoding
T1419 4047-4048 DT denotes a
T1421 4049-4055 JJ denotes single
T1422 4056-4061 NN denotes amino
T1423 4062-4066 NN denotes acid
T1420 4067-4073 NN denotes change
T1424 4074-4075 -LRB- denotes (
T1425 4075-4083 NN denotes XPDG602D
T1426 4083-4084 -RRB- denotes )
T1427 4085-4090 VBN denotes found
T1428 4091-4093 IN denotes in
T1429 4094-4097 DT denotes the
T1431 4098-4102 NN denotes XPCS
T1430 4103-4110 NN denotes patient
T1432 4111-4116 NN denotes XPCS2
T1433 4117-4118 -LRB- denotes (
T1435 4118-4124 NN denotes Figure
T1434 4125-4127 NN denotes 1A
T1436 4127-4128 SYM denotes –
T1437 4128-4130 NN denotes 1C
T1438 4130-4131 -RRB- denotes )
T1439 4131-4132 . denotes .
T1440 4132-4424 sentence denotes mRNA expression from the targeted allele could be detected in embryonic stem cells by RT-PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E).
T1441 4133-4137 NN denotes mRNA
T1442 4138-4148 NN denotes expression
T1444 4149-4153 IN denotes from
T1445 4154-4157 DT denotes the
T1447 4158-4166 VBN denotes targeted
T1446 4167-4173 NN denotes allele
T1448 4174-4179 MD denotes could
T1449 4180-4182 VB denotes be
T1443 4183-4191 VBN denotes detected
T1450 4192-4194 IN denotes in
T1451 4195-4204 JJ denotes embryonic
T1453 4205-4209 NN denotes stem
T1452 4210-4215 NNS denotes cells
T1454 4216-4218 IN denotes by
T1455 4219-4221 NN denotes RT
T1457 4221-4222 HYPH denotes -
T1456 4222-4225 NN denotes PCR
T1458 4226-4227 -LRB- denotes (
T1460 4227-4233 NN denotes Figure
T1459 4234-4236 NN denotes 1D
T1461 4236-4237 -RRB- denotes )
T1462 4237-4239 , denotes ,
T1463 4239-4247 IN denotes although
T1465 4248-4258 NN denotes expression
T1466 4259-4262 VBD denotes was
T1464 4263-4270 VBN denotes reduced
T1467 4271-4284 RB denotes approximately
T1468 4285-4286 CD denotes 5
T1469 4286-4287 HYPH denotes -
T1470 4287-4291 RB denotes fold
T1471 4292-4300 JJ denotes relative
T1472 4301-4303 IN denotes to
T1473 4304-4306 NN denotes wt
T1475 4307-4311 NN denotes mRNA
T1476 4312-4322 NN denotes transcript
T1474 4323-4329 NNS denotes levels
T1477 4330-4332 IN denotes as
T1478 4333-4343 VBN denotes determined
T1479 4344-4346 IN denotes by
T1480 4347-4355 NNP denotes Northern
T1481 4356-4364 VBG denotes blotting
T1482 4365-4367 IN denotes of
T1483 4368-4371 NN denotes RNA
T1484 4372-4376 IN denotes from
T1485 4377-4380 DT denotes the
T1486 4381-4387 NN denotes testis
T1487 4388-4390 IN denotes of
T1488 4391-4403 JJ denotes heterozygous
T1489 4404-4411 NNS denotes animals
T1490 4412-4413 -LRB- denotes (
T1492 4413-4419 NN denotes Figure
T1491 4420-4422 NN denotes 1E
T1493 4422-4423 -RRB- denotes )
T1494 4423-4424 . denotes .
T1495 4424-4608 sentence denotes Because patient XPCS2 was a hemizygote with mutant XPD protein (XPDG602D) expressed from a single allele, the corresponding mutation was expected to be viable in the homozygous state.
T1496 4425-4432 IN denotes Because
T1498 4433-4440 NN denotes patient
T1499 4441-4446 NN denotes XPCS2
T1497 4447-4450 VBD denotes was
T1501 4451-4452 DT denotes a
T1502 4453-4463 NN denotes hemizygote
T1503 4464-4468 IN denotes with
T1504 4469-4475 JJ denotes mutant
T1506 4476-4479 NN denotes XPD
T1505 4480-4487 NN denotes protein
T1507 4488-4489 -LRB- denotes (
T1508 4489-4497 NN denotes XPDG602D
T1509 4497-4498 -RRB- denotes )
T1510 4499-4508 VBN denotes expressed
T1511 4509-4513 IN denotes from
T1512 4514-4515 DT denotes a
T1514 4516-4522 JJ denotes single
T1513 4523-4529 NN denotes allele
T1515 4529-4531 , denotes ,
T1516 4531-4534 DT denotes the
T1518 4535-4548 VBG denotes corresponding
T1517 4549-4557 NN denotes mutation
T1519 4558-4561 VBD denotes was
T1500 4562-4570 VBN denotes expected
T1520 4571-4573 TO denotes to
T1521 4574-4576 VB denotes be
T1522 4577-4583 JJ denotes viable
T1523 4584-4586 IN denotes in
T1524 4587-4590 DT denotes the
T1526 4591-4601 JJ denotes homozygous
T1525 4602-4607 NN denotes state
T1527 4607-4608 . denotes .
T1528 4608-4745 sentence denotes However, homozygous mutant mice were not observed, neither amongst live births nor embryonic day 13.5 (E13.5) or E3.5 embryos (Table 1).
T1529 4609-4616 RB denotes However
T1531 4616-4618 , denotes ,
T1532 4618-4628 JJ denotes homozygous
T1534 4629-4635 JJ denotes mutant
T1533 4636-4640 NNS denotes mice
T1535 4641-4645 VBD denotes were
T1536 4646-4649 RB denotes not
T1530 4650-4658 VBN denotes observed
T1537 4658-4660 , denotes ,
T1538 4660-4667 CC denotes neither
T1539 4668-4675 IN denotes amongst
T1540 4676-4680 JJ denotes live
T1541 4681-4687 NNS denotes births
T1542 4688-4691 CC denotes nor
T1543 4692-4701 JJ denotes embryonic
T1544 4702-4705 NN denotes day
T1546 4706-4710 CD denotes 13.5
T1547 4711-4712 -LRB- denotes (
T1548 4712-4717 NN denotes E13.5
T1549 4717-4718 -RRB- denotes )
T1550 4719-4721 CC denotes or
T1551 4722-4726 NN denotes E3.5
T1545 4727-4734 NNS denotes embryos
T1552 4735-4736 -LRB- denotes (
T1553 4736-4741 NN denotes Table
T1554 4742-4743 CD denotes 1
T1555 4743-4744 -RRB- denotes )
T1556 4744-4745 . denotes .
T1557 4745-4840 sentence denotes The corresponding hypomorphic, mutant allele was thus designated as homozygous lethal (†XPCS).
T1558 4746-4749 DT denotes The
T1560 4750-4763 VBG denotes corresponding
T1561 4764-4775 JJ denotes hypomorphic
T1562 4775-4777 , denotes ,
T1563 4777-4783 JJ denotes mutant
T1559 4784-4790 NN denotes allele
T1565 4791-4794 VBD denotes was
T1566 4795-4799 RB denotes thus
T1564 4800-4810 VBN denotes designated
T1567 4811-4813 IN denotes as
T1568 4814-4824 JJ denotes homozygous
T1569 4825-4831 JJ denotes lethal
T1570 4832-4833 -LRB- denotes (
T1571 4833-4838 NN denotes †XPCS
T1572 4838-4839 -RRB- denotes )
T1573 4839-4840 . denotes .
T1574 4840-5030 sentence denotes Homozygous lethality of the XPCS allele is likely due to reduced levels of expression of this essential protein as a result of gene targeting (Figure 1A) rather than to the mutation itself.
T1575 4841-4851 JJ denotes Homozygous
T1576 4852-4861 NN denotes lethality
T1578 4862-4864 IN denotes of
T1579 4865-4868 DT denotes the
T1581 4869-4873 NN denotes XPCS
T1580 4874-4880 NN denotes allele
T1577 4881-4883 VBZ denotes is
T1582 4884-4890 RB denotes likely
T1583 4891-4894 IN denotes due
T1584 4895-4897 IN denotes to
T1585 4898-4905 VBN denotes reduced
T1586 4906-4912 NNS denotes levels
T1587 4913-4915 IN denotes of
T1588 4916-4926 NN denotes expression
T1589 4927-4929 IN denotes of
T1590 4930-4934 DT denotes this
T1592 4935-4944 JJ denotes essential
T1591 4945-4952 NN denotes protein
T1593 4953-4955 IN denotes as
T1594 4956-4957 DT denotes a
T1595 4958-4964 NN denotes result
T1596 4965-4967 IN denotes of
T1597 4968-4972 NN denotes gene
T1598 4973-4982 NN denotes targeting
T1599 4983-4984 -LRB- denotes (
T1601 4984-4990 NN denotes Figure
T1600 4991-4993 NN denotes 1A
T1602 4993-4994 -RRB- denotes )
T1603 4995-5001 JJ denotes rather
T1604 5002-5006 IN denotes than
T1605 5007-5009 IN denotes to
T1606 5010-5013 DT denotes the
T1607 5014-5022 NN denotes mutation
T1608 5023-5029 PRP denotes itself
T1609 5029-5030 . denotes .
T1610 5030-5142 sentence denotes Xpd ablation (XpdKO /KO ) is similarly incompatible with life beyond the earliest stages of embryogenesis [22].
T1611 5031-5034 NN denotes Xpd
T1612 5035-5043 NN denotes ablation
T1614 5044-5045 -LRB- denotes (
T1616 5045-5050 NN denotes XpdKO
T1617 5051-5052 HYPH denotes /
T1615 5052-5054 NN denotes KO
T1618 5055-5056 -RRB- denotes )
T1613 5057-5059 VBZ denotes is
T1619 5060-5069 RB denotes similarly
T1620 5070-5082 JJ denotes incompatible
T1621 5083-5087 IN denotes with
T1622 5088-5092 NN denotes life
T1623 5093-5099 IN denotes beyond
T1624 5100-5103 DT denotes the
T1626 5104-5112 JJS denotes earliest
T1625 5113-5119 NNS denotes stages
T1627 5120-5122 IN denotes of
T1628 5123-5136 NN denotes embryogenesis
T1629 5137-5138 -LRB- denotes [
T1630 5138-5140 CD denotes 22
T1631 5140-5141 -RRB- denotes ]
T1632 5141-5142 . denotes .
T1633 5142-5429 sentence denotes Consistent with this interpretation, a different targeted Xpd mutation encoding XPDR683W, which is associated with XP in the homozygous state in humans, was similarly underexpressed and lethal in the homozygous state (designated as †XP allele) (Figure 1A–1C; Table 1; unpublished data).
T1634 5143-5153 JJ denotes Consistent
T1636 5154-5158 IN denotes with
T1637 5159-5163 DT denotes this
T1638 5164-5178 NN denotes interpretation
T1639 5178-5180 , denotes ,
T1640 5180-5181 DT denotes a
T1642 5182-5191 JJ denotes different
T1643 5192-5200 VBN denotes targeted
T1644 5201-5204 NN denotes Xpd
T1641 5205-5213 NN denotes mutation
T1645 5214-5222 VBG denotes encoding
T1646 5223-5231 NN denotes XPDR683W
T1647 5231-5233 , denotes ,
T1648 5233-5238 WDT denotes which
T1650 5239-5241 VBZ denotes is
T1649 5242-5252 VBN denotes associated
T1651 5253-5257 IN denotes with
T1652 5258-5260 NN denotes XP
T1653 5261-5263 IN denotes in
T1654 5264-5267 DT denotes the
T1656 5268-5278 JJ denotes homozygous
T1655 5279-5284 NN denotes state
T1657 5285-5287 IN denotes in
T1658 5288-5294 NNS denotes humans
T1659 5294-5296 , denotes ,
T1635 5296-5299 VBD denotes was
T1660 5300-5309 RB denotes similarly
T1661 5310-5324 JJ denotes underexpressed
T1662 5325-5328 CC denotes and
T1663 5329-5335 JJ denotes lethal
T1664 5336-5338 IN denotes in
T1665 5339-5342 DT denotes the
T1667 5343-5353 JJ denotes homozygous
T1666 5354-5359 NN denotes state
T1668 5360-5361 -LRB- denotes (
T1669 5361-5371 VBN denotes designated
T1670 5372-5374 IN denotes as
T1671 5375-5378 NN denotes †XP
T1672 5379-5385 NN denotes allele
T1673 5385-5386 -RRB- denotes )
T1674 5387-5388 -LRB- denotes (
T1676 5388-5394 NN denotes Figure
T1675 5395-5397 NN denotes 1A
T1677 5397-5398 SYM denotes –
T1678 5398-5400 NN denotes 1C
T1679 5400-5401 : denotes ;
T1680 5402-5407 NN denotes Table
T1681 5408-5409 CD denotes 1
T1682 5409-5410 : denotes ;
T1683 5411-5422 JJ denotes unpublished
T1684 5423-5427 NNS denotes data
T1685 5427-5428 -RRB- denotes )
T1686 5428-5429 . denotes .
T1687 5429-5648 sentence denotes Also, a different targeting approach leading to the use of the native 3′UTR and removal of the neo gene resulted in normalisation of XpdXPCS mRNA levels and viable homozygous XpdXPCS/XPCS (XPDG602D/G602D) animals [23].
T1688 5430-5434 RB denotes Also
T1690 5434-5436 , denotes ,
T1691 5436-5437 DT denotes a
T1693 5438-5447 JJ denotes different
T1694 5448-5457 NN denotes targeting
T1692 5458-5466 NN denotes approach
T1695 5467-5474 VBG denotes leading
T1696 5475-5477 IN denotes to
T1697 5478-5481 DT denotes the
T1698 5482-5485 NN denotes use
T1699 5486-5488 IN denotes of
T1700 5489-5492 DT denotes the
T1702 5493-5499 JJ denotes native
T1703 5500-5501 CD denotes 3
T1704 5501-5502 SYM denotes ′
T1701 5502-5505 NN denotes UTR
T1705 5506-5509 CC denotes and
T1706 5510-5517 NN denotes removal
T1707 5518-5520 IN denotes of
T1708 5521-5524 DT denotes the
T1710 5525-5528 NN denotes neo
T1709 5529-5533 NN denotes gene
T1689 5534-5542 VBD denotes resulted
T1711 5543-5545 IN denotes in
T1712 5546-5559 NN denotes normalisation
T1713 5560-5562 IN denotes of
T1714 5563-5570 NN denotes XpdXPCS
T1716 5571-5575 NN denotes mRNA
T1715 5576-5582 NNS denotes levels
T1717 5583-5586 CC denotes and
T1718 5587-5593 JJ denotes viable
T1720 5594-5604 JJ denotes homozygous
T1721 5605-5612 NN denotes XpdXPCS
T1723 5612-5613 HYPH denotes /
T1722 5613-5617 NN denotes XPCS
T1724 5618-5619 -LRB- denotes (
T1726 5619-5627 NN denotes XPDG602D
T1727 5627-5628 HYPH denotes /
T1725 5628-5633 NN denotes G602D
T1728 5633-5634 -RRB- denotes )
T1719 5635-5642 NNS denotes animals
T1729 5643-5644 -LRB- denotes [
T1730 5644-5646 CD denotes 23
T1731 5646-5647 -RRB- denotes ]
T1732 5647-5648 . denotes .
T7095 5659-5668 NN denotes Targeting
T7096 5669-5671 IN denotes of
T7097 5672-5675 DT denotes the
T7099 5676-5681 NN denotes Mouse
T7100 5682-5685 NN denotes Xpd
T7098 5686-5690 NN denotes Gene
T7101 5690-5811 sentence denotes (A) Schematic representation of the genomic structure and partial restriction map of the wt and targeted mouse Xpd loci.
T7102 5691-5692 -LRB- denotes (
T7103 5692-5693 LS denotes A
T7105 5693-5694 -RRB- denotes )
T7106 5695-5704 JJ denotes Schematic
T7104 5705-5719 NN denotes representation
T7107 5720-5722 IN denotes of
T7108 5723-5726 DT denotes the
T7110 5727-5734 JJ denotes genomic
T7109 5735-5744 NN denotes structure
T7111 5745-5748 CC denotes and
T7112 5749-5756 JJ denotes partial
T7114 5757-5768 NN denotes restriction
T7113 5769-5772 NN denotes map
T7115 5773-5775 IN denotes of
T7116 5776-5779 DT denotes the
T7118 5780-5782 NN denotes wt
T7119 5783-5786 CC denotes and
T7120 5787-5795 VBN denotes targeted
T7121 5796-5801 NN denotes mouse
T7122 5802-5805 NN denotes Xpd
T7117 5806-5810 NNS denotes loci
T7123 5810-5811 . denotes .
T7124 5811-5936 sentence denotes For the wt Xpd allele, shaded boxes represent coding regions of exons 12 and 19–23; the 3′UTR is represented by an open box.
T7125 5812-5815 IN denotes For
T7127 5816-5819 DT denotes the
T7129 5820-5822 NN denotes wt
T7130 5823-5826 NN denotes Xpd
T7128 5827-5833 NN denotes allele
T7131 5833-5835 , denotes ,
T7132 5835-5841 JJ denotes shaded
T7133 5842-5847 NNS denotes boxes
T7134 5848-5857 VBP denotes represent
T7135 5858-5864 VBG denotes coding
T7136 5865-5872 NNS denotes regions
T7137 5873-5875 IN denotes of
T7138 5876-5881 NNS denotes exons
T7139 5882-5884 CD denotes 12
T7140 5885-5888 CC denotes and
T7141 5889-5891 CD denotes 19
T7142 5891-5892 SYM denotes –
T7143 5892-5894 CD denotes 23
T7144 5894-5895 : denotes ;
T7145 5896-5899 DT denotes the
T7147 5900-5901 CD denotes 3
T7148 5901-5902 SYM denotes ′
T7146 5902-5905 NN denotes UTR
T7149 5906-5908 VBZ denotes is
T7126 5909-5920 VBN denotes represented
T7150 5921-5923 IN denotes by
T7151 5924-5926 DT denotes an
T7153 5927-5931 JJ denotes open
T7152 5932-5935 NN denotes box
T7154 5935-5936 . denotes .
T7155 5936-6024 sentence denotes TGA indicates the translational stop codon; PolyA indicates the polyadenylation signal.
T7156 5937-5940 NN denotes TGA
T7157 5941-5950 VBZ denotes indicates
T7159 5951-5954 DT denotes the
T7161 5955-5968 JJ denotes translational
T7162 5969-5973 NN denotes stop
T7160 5974-5979 NN denotes codon
T7163 5979-5980 : denotes ;
T7164 5981-5986 NN denotes PolyA
T7158 5987-5996 VBZ denotes indicates
T7165 5997-6000 DT denotes the
T7167 6001-6016 NN denotes polyadenylation
T7166 6017-6023 NN denotes signal
T7168 6023-6024 . denotes .
T7169 6024-6216 sentence denotes For the XpdTTD targeted allele, the 194–base pair (bp) human XPD cDNA fragment fused to exon 22 is indicated as a striped box including the TTD (R722W) mutation indicated by a vertical arrow.
T7170 6025-6028 IN denotes For
T7172 6029-6032 DT denotes the
T7174 6033-6039 NN denotes XpdTTD
T7175 6040-6048 VBN denotes targeted
T7173 6049-6055 NN denotes allele
T7176 6055-6057 , denotes ,
T7177 6057-6060 DT denotes the
T7179 6061-6064 CD denotes 194
T7181 6064-6065 HYPH denotes –
T7182 6065-6069 NN denotes base
T7180 6070-6074 NN denotes pair
T7183 6075-6076 -LRB- denotes (
T7184 6076-6078 NN denotes bp
T7185 6078-6079 -RRB- denotes )
T7186 6080-6085 JJ denotes human
T7187 6086-6089 NN denotes XPD
T7188 6090-6094 NN denotes cDNA
T7178 6095-6103 NN denotes fragment
T7189 6104-6109 VBN denotes fused
T7190 6110-6112 IN denotes to
T7191 6113-6117 NN denotes exon
T7192 6118-6120 CD denotes 22
T7193 6121-6123 VBZ denotes is
T7171 6124-6133 VBN denotes indicated
T7194 6134-6136 IN denotes as
T7195 6137-6138 DT denotes a
T7197 6139-6146 VBN denotes striped
T7196 6147-6150 NN denotes box
T7198 6151-6160 VBG denotes including
T7199 6161-6164 DT denotes the
T7201 6165-6168 NN denotes TTD
T7202 6169-6170 -LRB- denotes (
T7203 6170-6175 NN denotes R722W
T7204 6175-6176 -RRB- denotes )
T7200 6177-6185 NN denotes mutation
T7205 6186-6195 VBN denotes indicated
T7206 6196-6198 IN denotes by
T7207 6199-6200 DT denotes a
T7209 6201-6209 JJ denotes vertical
T7208 6210-6215 NN denotes arrow
T7210 6215-6216 . denotes .
T7211 6216-6388 sentence denotes Chicken β-globin exons 2 and 3 including the 3′UTR are indicated as black boxes with corresponding Roman numerals followed by the β-globin polyadenylation signal (PolyA*).
T7212 6217-6224 NN denotes Chicken
T7214 6225-6226 NN denotes β
T7216 6226-6227 HYPH denotes -
T7215 6227-6233 NN denotes globin
T7217 6234-6239 NNS denotes exons
T7213 6240-6241 CD denotes 2
T7219 6242-6245 CC denotes and
T7220 6246-6247 CD denotes 3
T7221 6248-6257 VBG denotes including
T7222 6258-6261 DT denotes the
T7224 6262-6263 CD denotes 3
T7225 6263-6264 HYPH denotes ′
T7223 6264-6267 NN denotes UTR
T7226 6268-6271 VBP denotes are
T7218 6272-6281 VBN denotes indicated
T7227 6282-6284 IN denotes as
T7228 6285-6290 JJ denotes black
T7229 6291-6296 NNS denotes boxes
T7230 6297-6301 IN denotes with
T7231 6302-6315 VBG denotes corresponding
T7233 6316-6321 NNP denotes Roman
T7232 6322-6330 NNS denotes numerals
T7234 6331-6339 VBN denotes followed
T7235 6340-6342 IN denotes by
T7236 6343-6346 DT denotes the
T7238 6347-6348 NN denotes β
T7240 6348-6349 HYPH denotes -
T7239 6349-6355 NN denotes globin
T7241 6356-6371 NN denotes polyadenylation
T7237 6372-6378 NN denotes signal
T7242 6379-6380 -LRB- denotes (
T7243 6380-6386 NN denotes PolyA*
T7244 6386-6387 -RRB- denotes )
T7245 6387-6388 . denotes .
T7246 6388-6549 sentence denotes For the Xpd†XP and Xpd†XPCS targeted alleles, vertical arrows indicate XPCS (G602D-encoding) and XP (R683W-encoding) mutations in exons 19 and 22, respectively.
T7247 6389-6392 IN denotes For
T7249 6393-6396 DT denotes the
T7251 6397-6403 NN denotes Xpd†XP
T7252 6404-6407 CC denotes and
T7253 6408-6416 NN denotes Xpd†XPCS
T7254 6417-6425 VBN denotes targeted
T7250 6426-6433 NNS denotes alleles
T7255 6433-6435 , denotes ,
T7256 6435-6443 JJ denotes vertical
T7257 6444-6450 NNS denotes arrows
T7248 6451-6459 VBP denotes indicate
T7258 6460-6464 NN denotes XPCS
T7260 6465-6466 -LRB- denotes (
T7262 6466-6471 NN denotes G602D
T7263 6471-6472 HYPH denotes -
T7261 6472-6480 VBG denotes encoding
T7264 6480-6481 -RRB- denotes )
T7265 6482-6485 CC denotes and
T7266 6486-6488 NN denotes XP
T7267 6489-6490 -LRB- denotes (
T7269 6490-6495 NN denotes R683W
T7270 6495-6496 HYPH denotes -
T7268 6496-6504 VBG denotes encoding
T7271 6504-6505 -RRB- denotes )
T7259 6506-6515 NNS denotes mutations
T7272 6516-6518 IN denotes in
T7273 6519-6524 NNS denotes exons
T7274 6525-6527 CD denotes 19
T7275 6528-6531 CC denotes and
T7276 6532-6534 CD denotes 22
T7277 6534-6536 , denotes ,
T7278 6536-6548 RB denotes respectively
T7279 6548-6549 . denotes .
T7280 6549-6642 sentence denotes The unique 3′ probe located outside the targeting construct is marked by a thick black line.
T7281 6550-6553 DT denotes The
T7283 6554-6560 JJ denotes unique
T7284 6561-6562 CD denotes 3
T7285 6562-6563 SYM denotes ′
T7282 6564-6569 NN denotes probe
T7287 6570-6577 VBN denotes located
T7288 6578-6585 IN denotes outside
T7289 6586-6589 DT denotes the
T7291 6590-6599 VBG denotes targeting
T7290 6600-6609 NN denotes construct
T7292 6610-6612 VBZ denotes is
T7286 6613-6619 VBN denotes marked
T7293 6620-6622 IN denotes by
T7294 6623-6624 DT denotes a
T7296 6625-6630 JJ denotes thick
T7297 6631-6636 JJ denotes black
T7295 6637-6641 NN denotes line
T7298 6641-6642 . denotes .
T7299 6642-6722 sentence denotes Restriction sites: B, BamHI; C, ClaI; E, EcoRI; H, HindIII; Hp, HpaI; Sf, SfiI.
T7300 6643-6654 NN denotes Restriction
T7301 6655-6660 NNS denotes sites
T7302 6660-6662 : denotes :
T7303 6662-6663 NN denotes B
T7304 6663-6665 , denotes ,
T7305 6665-6670 NN denotes BamHI
T7306 6670-6671 : denotes ;
T7307 6672-6673 NN denotes C
T7308 6673-6675 , denotes ,
T7309 6675-6679 NN denotes ClaI
T7310 6679-6680 : denotes ;
T7311 6681-6682 NN denotes E
T7312 6682-6684 , denotes ,
T7313 6684-6689 NN denotes EcoRI
T7314 6689-6690 : denotes ;
T7315 6691-6692 NN denotes H
T7316 6692-6694 , denotes ,
T7317 6694-6701 NN denotes HindIII
T7318 6701-6702 : denotes ;
T7319 6703-6705 NN denotes Hp
T7320 6705-6707 , denotes ,
T7321 6707-6711 NN denotes HpaI
T7322 6711-6712 : denotes ;
T7323 6713-6715 NN denotes Sf
T7324 6715-6717 , denotes ,
T7325 6717-6721 NN denotes SfiI
T7326 6721-6722 . denotes .
T7327 6722-6900 sentence denotes (B) Southern blot analysis of EcoRI-digested genomic DNA from wt, Xpd†XPCS/wt, and Xpd†XP/wt recombinant embryonic stem cell clones hybridised with the 3′ probe depicted in (A).
T7328 6723-6724 -LRB- denotes (
T7329 6724-6725 LS denotes B
T7331 6725-6726 -RRB- denotes )
T7332 6727-6735 NNP denotes Southern
T7333 6736-6740 NN denotes blot
T7330 6741-6749 NN denotes analysis
T7334 6750-6752 IN denotes of
T7335 6753-6758 NN denotes EcoRI
T7337 6758-6759 HYPH denotes -
T7336 6759-6767 VBN denotes digested
T7339 6768-6775 JJ denotes genomic
T7338 6776-6779 NN denotes DNA
T7340 6780-6784 IN denotes from
T7341 6785-6787 NN denotes wt
T7343 6787-6789 , denotes ,
T7344 6789-6797 NN denotes Xpd†XPCS
T7346 6797-6798 HYPH denotes /
T7345 6798-6800 NN denotes wt
T7347 6800-6802 , denotes ,
T7348 6802-6805 CC denotes and
T7349 6806-6812 NN denotes Xpd†XP
T7351 6812-6813 HYPH denotes /
T7350 6813-6815 NN denotes wt
T7352 6816-6827 JJ denotes recombinant
T7353 6828-6837 JJ denotes embryonic
T7355 6838-6842 NN denotes stem
T7354 6843-6847 NN denotes cell
T7342 6848-6854 NNS denotes clones
T7356 6855-6865 VBN denotes hybridised
T7357 6866-6870 IN denotes with
T7358 6871-6874 DT denotes the
T7360 6875-6876 CD denotes 3
T7361 6876-6877 SYM denotes ′
T7359 6878-6883 NN denotes probe
T7362 6884-6892 VBN denotes depicted
T7363 6893-6895 IN denotes in
T7364 6896-6897 -LRB- denotes (
T7365 6897-6898 NN denotes A
T7366 6898-6899 -RRB- denotes )
T7367 6899-6900 . denotes .
T7368 6900-7026 sentence denotes The wt allele yields a 6.5-kilobase (kb) fragment, whereas both targeted Xpd†XP and Xpd†XPCS alleles yield a 5.1-kb fragment.
T7369 6901-6904 DT denotes The
T7371 6905-6907 NN denotes wt
T7370 6908-6914 NN denotes allele
T7372 6915-6921 VBZ denotes yields
T7373 6922-6923 DT denotes a
T7375 6924-6927 CD denotes 6.5
T7377 6927-6928 HYPH denotes -
T7376 6928-6936 NN denotes kilobase
T7378 6937-6938 -LRB- denotes (
T7379 6938-6940 NN denotes kb
T7380 6940-6941 -RRB- denotes )
T7374 6942-6950 NN denotes fragment
T7381 6950-6952 , denotes ,
T7382 6952-6959 IN denotes whereas
T7384 6960-6964 CC denotes both
T7386 6965-6973 VBN denotes targeted
T7387 6974-6980 NN denotes Xpd†XP
T7388 6981-6984 CC denotes and
T7389 6985-6993 NN denotes Xpd†XPCS
T7385 6994-7001 NNS denotes alleles
T7383 7002-7007 VBP denotes yield
T7390 7008-7009 DT denotes a
T7392 7010-7013 CD denotes 5.1
T7394 7013-7014 HYPH denotes -
T7393 7014-7016 NN denotes kb
T7391 7017-7025 NN denotes fragment
T7395 7025-7026 . denotes .
T7396 7026-7177 sentence denotes (C) Genotyping of wt and targeted alleles by PCR using primers F2, R1, and mR as indicated in (A) yields fragments of 399 bp and 468 bp, respectively.
T7397 7027-7028 -LRB- denotes (
T7398 7028-7029 LS denotes C
T7400 7029-7030 -RRB- denotes )
T7399 7031-7041 NN denotes Genotyping
T7401 7042-7044 IN denotes of
T7402 7045-7047 NN denotes wt
T7404 7048-7051 CC denotes and
T7405 7052-7060 VBN denotes targeted
T7403 7061-7068 NNS denotes alleles
T7406 7069-7071 IN denotes by
T7407 7072-7075 NN denotes PCR
T7408 7076-7081 VBG denotes using
T7409 7082-7089 NNS denotes primers
T7410 7090-7092 NN denotes F2
T7411 7092-7094 , denotes ,
T7412 7094-7096 NN denotes R1
T7413 7096-7098 , denotes ,
T7414 7098-7101 CC denotes and
T7415 7102-7104 NN denotes mR
T7416 7105-7107 IN denotes as
T7417 7108-7117 VBN denotes indicated
T7418 7118-7120 IN denotes in
T7419 7121-7122 -LRB- denotes (
T7420 7122-7123 LS denotes A
T7422 7123-7124 -RRB- denotes )
T7423 7125-7131 VBZ denotes yields
T7421 7132-7141 NNS denotes fragments
T7424 7142-7144 IN denotes of
T7425 7145-7148 CD denotes 399
T7426 7149-7151 NN denotes bp
T7427 7152-7155 CC denotes and
T7428 7156-7159 CD denotes 468
T7429 7160-7162 NN denotes bp
T7430 7162-7164 , denotes ,
T7431 7164-7176 RB denotes respectively
T7432 7176-7177 . denotes .
T7433 7177-7421 sentence denotes (D) RT-PCR detection of mRNA expression originating from the targeted †XP and †XPCS alleles in embryonic stem cell clones using primers F1 (hybridising outside the targeting construct) and mR as indicated in (A) results in a 1,416-bp fragment.
T7434 7178-7179 -LRB- denotes (
T7435 7179-7180 LS denotes D
T7437 7180-7181 -RRB- denotes )
T7438 7182-7184 NN denotes RT
T7440 7184-7185 HYPH denotes -
T7439 7185-7188 NN denotes PCR
T7441 7189-7198 NN denotes detection
T7442 7199-7201 IN denotes of
T7443 7202-7206 NN denotes mRNA
T7444 7207-7217 NN denotes expression
T7445 7218-7229 VBG denotes originating
T7446 7230-7234 IN denotes from
T7447 7235-7238 DT denotes the
T7449 7239-7247 VBN denotes targeted
T7450 7248-7251 NN denotes †XP
T7451 7252-7255 CC denotes and
T7452 7256-7261 NN denotes †XPCS
T7448 7262-7269 NNS denotes alleles
T7453 7270-7272 IN denotes in
T7454 7273-7282 JJ denotes embryonic
T7456 7283-7287 NN denotes stem
T7455 7288-7292 NN denotes cell
T7457 7293-7299 NNS denotes clones
T7458 7300-7305 VBG denotes using
T7459 7306-7313 NNS denotes primers
T7460 7314-7316 NN denotes F1
T7461 7317-7318 -LRB- denotes (
T7462 7318-7329 VBG denotes hybridising
T7463 7330-7337 IN denotes outside
T7464 7338-7341 DT denotes the
T7466 7342-7351 VBG denotes targeting
T7465 7352-7361 NN denotes construct
T7467 7361-7362 -RRB- denotes )
T7468 7363-7366 CC denotes and
T7469 7367-7369 NN denotes mR
T7470 7370-7372 IN denotes as
T7471 7373-7382 VBN denotes indicated
T7472 7383-7385 IN denotes in
T7473 7386-7387 -LRB- denotes (
T7474 7387-7388 NN denotes A
T7475 7388-7389 -RRB- denotes )
T7436 7390-7397 VBZ denotes results
T7476 7398-7400 IN denotes in
T7477 7401-7402 DT denotes a
T7479 7403-7408 CD denotes 1,416
T7481 7408-7409 HYPH denotes -
T7480 7409-7411 NN denotes bp
T7478 7412-7420 NN denotes fragment
T7482 7420-7421 . denotes .
T7483 7421-7613 sentence denotes (E) Northern blot analysis of total RNA isolated from testis of homozygous wt and XpdTTD/TTD, heterozygous Xpd†XPCS/wt and XpdTTD/wt, and compound heterozygous Xpd†XPCS/TTD mice as indicated.
T7484 7422-7423 -LRB- denotes (
T7485 7423-7424 LS denotes E
T7487 7424-7425 -RRB- denotes )
T7488 7426-7434 NNP denotes Northern
T7489 7435-7439 NN denotes blot
T7486 7440-7448 NN denotes analysis
T7490 7449-7451 IN denotes of
T7491 7452-7457 JJ denotes total
T7492 7458-7461 NN denotes RNA
T7493 7462-7470 VBN denotes isolated
T7494 7471-7475 IN denotes from
T7495 7476-7482 NN denotes testis
T7496 7483-7485 IN denotes of
T7497 7486-7496 JJ denotes homozygous
T7498 7497-7499 NN denotes wt
T7500 7500-7503 CC denotes and
T7501 7504-7510 NN denotes XpdTTD
T7503 7510-7511 HYPH denotes /
T7502 7511-7514 NN denotes TTD
T7504 7514-7516 , denotes ,
T7505 7516-7528 JJ denotes heterozygous
T7507 7529-7537 NN denotes Xpd†XPCS
T7508 7537-7538 HYPH denotes /
T7506 7538-7540 NN denotes wt
T7509 7541-7544 CC denotes and
T7510 7545-7551 NN denotes XpdTTD
T7512 7551-7552 HYPH denotes /
T7511 7552-7554 NN denotes wt
T7513 7554-7556 , denotes ,
T7514 7556-7559 CC denotes and
T7515 7560-7568 JJ denotes compound
T7517 7569-7581 JJ denotes heterozygous
T7518 7582-7590 NN denotes Xpd†XPCS
T7519 7590-7591 HYPH denotes /
T7516 7591-7594 NN denotes TTD
T7499 7595-7599 NNS denotes mice
T7520 7600-7602 IN denotes as
T7521 7603-7612 VBN denotes indicated
T7522 7612-7613 . denotes .
T7523 7613-7751 sentence denotes Hybridisation with a 1.4-kb mouse Xpd cDNA probe detects mRNAs of 4, 3.3, and 2.7 kb from wt, Xpd†XPCS, and XpdTTD alleles, respectively.
T7524 7614-7627 NN denotes Hybridisation
T7526 7628-7632 IN denotes with
T7527 7633-7634 DT denotes a
T7529 7635-7638 CD denotes 1.4
T7531 7638-7639 HYPH denotes -
T7530 7639-7641 NN denotes kb
T7532 7642-7647 NN denotes mouse
T7533 7648-7651 NN denotes Xpd
T7534 7652-7656 NN denotes cDNA
T7528 7657-7662 NN denotes probe
T7525 7663-7670 VBZ denotes detects
T7535 7671-7676 NNS denotes mRNAs
T7536 7677-7679 IN denotes of
T7537 7680-7681 CD denotes 4
T7539 7681-7683 , denotes ,
T7540 7683-7686 CD denotes 3.3
T7541 7686-7688 , denotes ,
T7542 7688-7691 CC denotes and
T7543 7692-7695 CD denotes 2.7
T7538 7696-7698 NN denotes kb
T7544 7699-7703 IN denotes from
T7545 7704-7706 NN denotes wt
T7547 7706-7708 , denotes ,
T7548 7708-7716 NN denotes Xpd†XPCS
T7549 7716-7718 , denotes ,
T7550 7718-7721 CC denotes and
T7551 7722-7728 NN denotes XpdTTD
T7546 7729-7736 NNS denotes alleles
T7552 7736-7738 , denotes ,
T7553 7738-7750 RB denotes respectively
T7554 7750-7751 . denotes .
T7555 7751-7845 sentence denotes An ethidium bromide (EtBr)–stained gel showing the amount of total RNA loaded is shown below.
T7556 7752-7754 DT denotes An
T7558 7755-7763 NN denotes ethidium
T7559 7764-7771 NN denotes bromide
T7561 7772-7773 -LRB- denotes (
T7562 7773-7777 NN denotes EtBr
T7563 7777-7778 -RRB- denotes )
T7564 7778-7779 HYPH denotes –
T7560 7779-7786 VBN denotes stained
T7557 7787-7790 NN denotes gel
T7566 7791-7798 VBG denotes showing
T7567 7799-7802 DT denotes the
T7568 7803-7809 NN denotes amount
T7569 7810-7812 IN denotes of
T7570 7813-7818 JJ denotes total
T7571 7819-7822 NN denotes RNA
T7572 7823-7829 VBN denotes loaded
T7573 7830-7832 VBZ denotes is
T7565 7833-7838 VBN denotes shown
T7574 7839-7844 RB denotes below
T7575 7844-7845 . denotes .
T9211 7855-7864 NN denotes Frequency
T9212 7865-7867 IN denotes of
T9213 7868-7874 NN denotes Xpd†XP
T9215 7874-7875 HYPH denotes /
T9214 7875-7878 NN denotes †XP
T9216 7878-7880 , denotes ,
T9217 7880-7888 NN denotes Xpd†XPCS
T9219 7888-7889 HYPH denotes /
T9218 7889-7894 NN denotes †XPCS
T9220 7894-7896 , denotes ,
T9221 7896-7899 CC denotes and
T9222 7900-7908 NN denotes Compound
T9224 7909-7921 JJ denotes Heterozygous
T9225 7922-7928 NN denotes Xpd†XP
T9226 7928-7929 HYPH denotes /
T9223 7929-7934 NN denotes †XPCS
T9227 7935-7942 NNS denotes Embryos
T9228 7943-7946 CC denotes and
T9229 7947-7956 NN denotes Offspring
T1954 7958-7959 `` denotes “
T1956 7959-7963 JJ denotes Null
T1957 7963-7964 '' denotes ”
T1955 7965-7971 NN denotes Allele
T1959 7972-7975 MD denotes Can
T1958 7976-7985 VB denotes Alleviate
T1960 7986-7999 JJ denotes Developmental
T1961 8000-8005 NN denotes Delay
T1962 8005-8007 , denotes ,
T1963 8007-8011 NN denotes Skin
T1965 8011-8013 , denotes ,
T1966 8013-8016 CC denotes and
T1967 8017-8021 NN denotes Hair
T1964 8022-8030 NNS denotes Features
T1968 8031-8033 IN denotes of
T1969 8034-8037 NN denotes TTD
T1970 8037-8259 sentence denotes To test the potential of a homozygous lethal “null” allele to nevertheless contribute to organismal phenotype, we combined an Xpd†XPCS allele with a viable XpdTTD allele by crossing the corresponding heterozygous animals.
T1971 8038-8040 TO denotes To
T1972 8041-8045 VB denotes test
T1974 8046-8049 DT denotes the
T1975 8050-8059 NN denotes potential
T1976 8060-8062 IN denotes of
T1977 8063-8064 DT denotes a
T1979 8065-8075 JJ denotes homozygous
T1980 8076-8082 JJ denotes lethal
T1981 8083-8084 `` denotes “
T1982 8084-8088 JJ denotes null
T1983 8088-8089 '' denotes ”
T1978 8090-8096 NN denotes allele
T1984 8097-8099 TO denotes to
T1986 8100-8112 RB denotes nevertheless
T1985 8113-8123 VB denotes contribute
T1987 8124-8126 IN denotes to
T1988 8127-8137 JJ denotes organismal
T1989 8138-8147 NN denotes phenotype
T1990 8147-8149 , denotes ,
T1991 8149-8151 PRP denotes we
T1973 8152-8160 VBD denotes combined
T1992 8161-8163 DT denotes an
T1994 8164-8172 NN denotes Xpd†XPCS
T1993 8173-8179 NN denotes allele
T1995 8180-8184 IN denotes with
T1996 8185-8186 DT denotes a
T1998 8187-8193 JJ denotes viable
T1999 8194-8200 NN denotes XpdTTD
T1997 8201-8207 NN denotes allele
T2000 8208-8210 IN denotes by
T2001 8211-8219 VBG denotes crossing
T2002 8220-8223 DT denotes the
T2004 8224-8237 VBG denotes corresponding
T2005 8238-8250 JJ denotes heterozygous
T2003 8251-8258 NNS denotes animals
T2006 8258-8259 . denotes .
T2007 8259-8430 sentence denotes Similar to hemizygous TTD mice carrying one true Xpd knockout allele (XpdTTD/KO), compound heterozygous XpdTTD/†XPCS mice were born at the expected Mendelian frequencies.
T2008 8260-8267 JJ denotes Similar
T2010 8268-8270 IN denotes to
T2011 8271-8281 JJ denotes hemizygous
T2013 8282-8285 NN denotes TTD
T2012 8286-8290 NNS denotes mice
T2014 8291-8299 VBG denotes carrying
T2015 8300-8303 CD denotes one
T2017 8304-8308 JJ denotes true
T2018 8309-8312 NN denotes Xpd
T2019 8313-8321 NN denotes knockout
T2016 8322-8328 NN denotes allele
T2020 8329-8330 -LRB- denotes (
T2022 8330-8336 NN denotes XpdTTD
T2023 8336-8337 HYPH denotes /
T2021 8337-8339 NN denotes KO
T2024 8339-8340 -RRB- denotes )
T2025 8340-8342 , denotes ,
T2026 8342-8350 NN denotes compound
T2028 8351-8363 JJ denotes heterozygous
T2029 8364-8370 NN denotes XpdTTD
T2031 8370-8371 HYPH denotes /
T2030 8371-8376 NN denotes †XPCS
T2027 8377-8381 NNS denotes mice
T2032 8382-8386 VBD denotes were
T2009 8387-8391 VBN denotes born
T2033 8392-8394 IN denotes at
T2034 8395-8398 DT denotes the
T2036 8399-8407 VBN denotes expected
T2037 8408-8417 JJ denotes Mendelian
T2035 8418-8429 NNS denotes frequencies
T2038 8429-8430 . denotes .
T2039 8430-8626 sentence denotes Expression from the Xpd†XPCS allele was also reduced in the testis of compound heterozygous animals, whereas expression from the XpdTTD allele was increased relative to wt by ~5-fold (Figure 1E).
T2040 8431-8441 NN denotes Expression
T2042 8442-8446 IN denotes from
T2043 8447-8450 DT denotes the
T2045 8451-8459 NN denotes Xpd†XPCS
T2044 8460-8466 NN denotes allele
T2046 8467-8470 VBD denotes was
T2047 8471-8475 RB denotes also
T2041 8476-8483 VBN denotes reduced
T2048 8484-8486 IN denotes in
T2049 8487-8490 DT denotes the
T2050 8491-8497 NN denotes testis
T2051 8498-8500 IN denotes of
T2052 8501-8509 NN denotes compound
T2054 8510-8522 JJ denotes heterozygous
T2053 8523-8530 NNS denotes animals
T2055 8530-8532 , denotes ,
T2056 8532-8539 IN denotes whereas
T2058 8540-8550 NN denotes expression
T2059 8551-8555 IN denotes from
T2060 8556-8559 DT denotes the
T2062 8560-8566 NN denotes XpdTTD
T2061 8567-8573 NN denotes allele
T2063 8574-8577 VBD denotes was
T2057 8578-8587 VBN denotes increased
T2064 8588-8596 JJ denotes relative
T2065 8597-8599 IN denotes to
T2066 8600-8602 NN denotes wt
T2067 8603-8605 IN denotes by
T2068 8606-8607 SYM denotes ~
T2069 8607-8613 RB denotes 5-fold
T2070 8614-8615 -LRB- denotes (
T2072 8615-8621 NN denotes Figure
T2071 8622-8624 NN denotes 1E
T2073 8624-8625 -RRB- denotes )
T2074 8625-8626 . denotes .
T2075 8626-8879 sentence denotes Because of a lack of available antibodies and the inability to distinguish amongst various mutant forms of XPD differing only by single amino acid substitutions, we were unable to ascertain the relative amount of XPD protein from the different alleles.
T2076 8627-8634 IN denotes Because
T2078 8635-8637 IN denotes of
T2079 8638-8639 DT denotes a
T2080 8640-8644 NN denotes lack
T2081 8645-8647 IN denotes of
T2082 8648-8657 JJ denotes available
T2083 8658-8668 NNS denotes antibodies
T2084 8669-8672 CC denotes and
T2085 8673-8676 DT denotes the
T2086 8677-8686 NN denotes inability
T2087 8687-8689 TO denotes to
T2088 8690-8701 VB denotes distinguish
T2089 8702-8709 IN denotes amongst
T2090 8710-8717 JJ denotes various
T2092 8718-8724 JJ denotes mutant
T2091 8725-8730 NNS denotes forms
T2093 8731-8733 IN denotes of
T2094 8734-8737 NN denotes XPD
T2095 8738-8747 VBG denotes differing
T2096 8748-8752 RB denotes only
T2097 8753-8755 IN denotes by
T2098 8756-8762 JJ denotes single
T2100 8763-8768 NN denotes amino
T2101 8769-8773 NN denotes acid
T2099 8774-8787 NNS denotes substitutions
T2102 8787-8789 , denotes ,
T2103 8789-8791 PRP denotes we
T2077 8792-8796 VBD denotes were
T2104 8797-8803 JJ denotes unable
T2105 8804-8806 TO denotes to
T2106 8807-8816 VB denotes ascertain
T2107 8817-8820 DT denotes the
T2109 8821-8829 JJ denotes relative
T2108 8830-8836 NN denotes amount
T2110 8837-8839 IN denotes of
T2111 8840-8843 NN denotes XPD
T2112 8844-8851 NN denotes protein
T2113 8852-8856 IN denotes from
T2114 8857-8860 DT denotes the
T2116 8861-8870 JJ denotes different
T2115 8871-8878 NNS denotes alleles
T2117 8878-8879 . denotes .
T2118 8879-9186 sentence denotes Despite reduced levels of mRNA expression, the homozygous lethal Xpd†XPCS allele ameliorated multiple XpdTTD-associated disease symptoms in compound heterozygous XpdTTD/†XPCS animals including the hallmark brittle hair and cutaneous features fully penetrant in homo- and hemizygous TTD mice (Figure 2A–2C).
T2119 8880-8887 IN denotes Despite
T2121 8888-8895 VBN denotes reduced
T2122 8896-8902 NNS denotes levels
T2123 8903-8905 IN denotes of
T2124 8906-8910 NN denotes mRNA
T2125 8911-8921 NN denotes expression
T2126 8921-8923 , denotes ,
T2127 8923-8926 DT denotes the
T2129 8927-8937 JJ denotes homozygous
T2130 8938-8944 JJ denotes lethal
T2131 8945-8953 NN denotes Xpd†XPCS
T2128 8954-8960 NN denotes allele
T2120 8961-8972 VBD denotes ameliorated
T2132 8973-8981 JJ denotes multiple
T2134 8982-8988 NN denotes XpdTTD
T2136 8988-8989 HYPH denotes -
T2135 8989-8999 JJ denotes associated
T2137 9000-9007 NN denotes disease
T2133 9008-9016 NNS denotes symptoms
T2138 9017-9019 IN denotes in
T2139 9020-9028 JJ denotes compound
T2141 9029-9041 JJ denotes heterozygous
T2142 9042-9048 NN denotes XpdTTD
T2144 9048-9049 HYPH denotes /
T2143 9049-9054 NN denotes †XPCS
T2140 9055-9062 NNS denotes animals
T2145 9063-9072 VBG denotes including
T2146 9073-9076 DT denotes the
T2148 9077-9085 NN denotes hallmark
T2149 9086-9093 JJ denotes brittle
T2147 9094-9098 NN denotes hair
T2150 9099-9102 CC denotes and
T2151 9103-9112 JJ denotes cutaneous
T2152 9113-9121 NNS denotes features
T2153 9122-9127 RB denotes fully
T2154 9128-9137 JJ denotes penetrant
T2155 9138-9140 IN denotes in
T2156 9141-9145 AFX denotes homo
T2158 9145-9146 HYPH denotes -
T2159 9147-9150 CC denotes and
T2157 9151-9161 JJ denotes hemizygous
T2161 9162-9165 NN denotes TTD
T2160 9166-9170 NNS denotes mice
T2162 9171-9172 -LRB- denotes (
T2164 9172-9178 NN denotes Figure
T2163 9179-9181 NN denotes 2A
T2165 9181-9182 SYM denotes –
T2166 9182-9184 NN denotes 2C
T2167 9184-9185 -RRB- denotes )
T2168 9185-9186 . denotes .
T2169 9186-9510 sentence denotes In marked contrast to XpdTTD/TTD (and XpdTTD/KO) mice, which display complete hair loss in the first hair cycle and partial hair loss in subsequent cycles throughout their lives [21], compound heterozygous XpdTTD/†XPCS mice displayed some hair loss only during the first hair cycle and only locally at the back (Figure 2A).
T2170 9187-9189 IN denotes In
T2172 9190-9196 JJ denotes marked
T2173 9197-9205 NN denotes contrast
T2174 9206-9208 IN denotes to
T2175 9209-9215 NN denotes XpdTTD
T2177 9215-9216 HYPH denotes /
T2176 9216-9219 NN denotes TTD
T2179 9220-9221 -LRB- denotes (
T2180 9221-9224 CC denotes and
T2181 9225-9231 NN denotes XpdTTD
T2183 9231-9232 HYPH denotes /
T2182 9232-9234 NN denotes KO
T2184 9234-9235 -RRB- denotes )
T2178 9236-9240 NNS denotes mice
T2185 9240-9242 , denotes ,
T2186 9242-9247 WDT denotes which
T2187 9248-9255 VBP denotes display
T2188 9256-9264 JJ denotes complete
T2190 9265-9269 NN denotes hair
T2189 9270-9274 NN denotes loss
T2191 9275-9277 IN denotes in
T2192 9278-9281 DT denotes the
T2194 9282-9287 JJ denotes first
T2195 9288-9292 NN denotes hair
T2193 9293-9298 NN denotes cycle
T2196 9299-9302 CC denotes and
T2197 9303-9310 JJ denotes partial
T2199 9311-9315 NN denotes hair
T2198 9316-9320 NN denotes loss
T2200 9321-9323 IN denotes in
T2201 9324-9334 JJ denotes subsequent
T2202 9335-9341 NNS denotes cycles
T2203 9342-9352 IN denotes throughout
T2204 9353-9358 PRP$ denotes their
T2205 9359-9364 NNS denotes lives
T2206 9365-9366 -LRB- denotes [
T2207 9366-9368 CD denotes 21
T2208 9368-9369 -RRB- denotes ]
T2209 9369-9371 , denotes ,
T2210 9371-9379 NN denotes compound
T2212 9380-9392 JJ denotes heterozygous
T2213 9393-9405 NN denotes XpdTTD/†XPCS
T2211 9406-9410 NNS denotes mice
T2171 9411-9420 VBD denotes displayed
T2214 9421-9425 DT denotes some
T2216 9426-9430 NN denotes hair
T2215 9431-9435 NN denotes loss
T2217 9436-9440 RB denotes only
T2218 9441-9447 IN denotes during
T2219 9448-9451 DT denotes the
T2221 9452-9457 JJ denotes first
T2222 9458-9462 NN denotes hair
T2220 9463-9468 NN denotes cycle
T2223 9469-9472 CC denotes and
T2224 9473-9477 RB denotes only
T2225 9478-9485 RB denotes locally
T2226 9486-9488 IN denotes at
T2227 9489-9492 DT denotes the
T2228 9493-9497 NN denotes back
T2229 9498-9499 -LRB- denotes (
T2231 9499-9505 NN denotes Figure
T2230 9506-9508 NN denotes 2A
T2232 9508-9509 -RRB- denotes )
T2233 9509-9510 . denotes .
T2234 9510-9704 sentence denotes Scanning electron microscope analysis of XpdTTD/†XPCS hair revealed an almost normal appearance, with TTD-like features such as broken hairs found only at very low frequency (unpublished data).
T2235 9511-9519 NN denotes Scanning
T2237 9520-9528 NN denotes electron
T2236 9529-9539 NN denotes microscope
T2238 9540-9548 NN denotes analysis
T2240 9549-9551 IN denotes of
T2241 9552-9558 NN denotes XpdTTD
T2243 9558-9559 HYPH denotes /
T2242 9559-9564 NN denotes †XPCS
T2244 9565-9569 NN denotes hair
T2239 9570-9578 VBD denotes revealed
T2245 9579-9581 DT denotes an
T2247 9582-9588 RB denotes almost
T2248 9589-9595 JJ denotes normal
T2246 9596-9606 NN denotes appearance
T2249 9606-9608 , denotes ,
T2250 9608-9612 IN denotes with
T2251 9613-9616 NN denotes TTD
T2253 9616-9617 HYPH denotes -
T2252 9617-9621 JJ denotes like
T2254 9622-9630 NNS denotes features
T2255 9631-9635 JJ denotes such
T2256 9636-9638 IN denotes as
T2257 9639-9645 JJ denotes broken
T2258 9646-9651 NNS denotes hairs
T2259 9652-9657 VBN denotes found
T2260 9658-9662 RB denotes only
T2261 9663-9665 IN denotes at
T2262 9666-9670 RB denotes very
T2263 9671-9674 JJ denotes low
T2264 9675-9684 NN denotes frequency
T2265 9685-9686 -LRB- denotes (
T2267 9686-9697 JJ denotes unpublished
T2266 9698-9702 NNS denotes data
T2268 9702-9703 -RRB- denotes )
T2269 9703-9704 . denotes .
T2270 9704-9891 sentence denotes Amino acid analysis confirmed that cysteine levels in the hair of the XpdTTD/†XPCS mice were significantly higher than in XpdTTD/TTD animals, but remained below the wt level (Figure 2C).
T2271 9705-9710 NN denotes Amino
T2272 9711-9715 NN denotes acid
T2273 9716-9724 NN denotes analysis
T2274 9725-9734 VBD denotes confirmed
T2275 9735-9739 IN denotes that
T2277 9740-9748 NN denotes cysteine
T2278 9749-9755 NNS denotes levels
T2279 9756-9758 IN denotes in
T2280 9759-9762 DT denotes the
T2281 9763-9767 NN denotes hair
T2282 9768-9770 IN denotes of
T2283 9771-9774 DT denotes the
T2285 9775-9781 NN denotes XpdTTD
T2287 9781-9782 HYPH denotes /
T2286 9782-9787 NN denotes †XPCS
T2284 9788-9792 NNS denotes mice
T2276 9793-9797 VBD denotes were
T2288 9798-9811 RB denotes significantly
T2289 9812-9818 JJR denotes higher
T2290 9819-9823 IN denotes than
T2291 9824-9826 IN denotes in
T2292 9827-9833 NN denotes XpdTTD
T2294 9833-9834 HYPH denotes /
T2293 9834-9837 NN denotes TTD
T2295 9838-9845 NNS denotes animals
T2296 9845-9847 , denotes ,
T2297 9847-9850 CC denotes but
T2298 9851-9859 VBD denotes remained
T2299 9860-9865 IN denotes below
T2300 9866-9869 DT denotes the
T2302 9870-9872 NN denotes wt
T2301 9873-9878 NN denotes level
T2303 9879-9880 -LRB- denotes (
T2305 9880-9886 NN denotes Figure
T2304 9887-9889 NN denotes 2C
T2306 9889-9890 -RRB- denotes )
T2307 9890-9891 . denotes .
T2308 9891-10039 sentence denotes TTD hemizygotes (XpdTTD/KO) do not display significant differences in cutaneous features and longevity relative to homozygous XpdTTD/TTD mice [21].
T2309 9892-9895 NN denotes TTD
T2310 9896-9907 NNS denotes hemizygotes
T2312 9908-9909 -LRB- denotes (
T2314 9909-9915 NN denotes XpdTTD
T2315 9915-9916 HYPH denotes /
T2313 9916-9918 NN denotes KO
T2316 9918-9919 -RRB- denotes )
T2317 9920-9922 VBP denotes do
T2318 9923-9926 RB denotes not
T2311 9927-9934 VB denotes display
T2319 9935-9946 JJ denotes significant
T2320 9947-9958 NNS denotes differences
T2321 9959-9961 IN denotes in
T2322 9962-9971 JJ denotes cutaneous
T2323 9972-9980 NNS denotes features
T2324 9981-9984 CC denotes and
T2325 9985-9994 NN denotes longevity
T2326 9995-10003 JJ denotes relative
T2327 10004-10006 IN denotes to
T2328 10007-10017 JJ denotes homozygous
T2330 10018-10024 NN denotes XpdTTD
T2332 10024-10025 HYPH denotes /
T2331 10025-10028 NN denotes TTD
T2329 10029-10033 NNS denotes mice
T2333 10034-10035 -LRB- denotes [
T2334 10035-10037 CD denotes 21
T2335 10037-10038 -RRB- denotes ]
T2336 10038-10039 . denotes .
T2337 10039-11699 sentence denotes Figure 2 Partial Rescue of TTD Cutaneous, Blood, and Developmental Phenotypes in Compound Heterozygous XpdTTD/†XPCS Mice (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice. Insets: images of first-round hair loss. (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice. TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice. Magnification 400×. (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice. The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice. Error bars indicate standard error of the mean (SEM). (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice. The p-values indicate the significance of the difference relative to wt. Error bars indicate SEM. (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%). Error bars indicate SEM. Other prominent TTD features in the epidermis, including acanthosis (thickening of the layer of the nucleated cells), hyperkeratosis (prominent thickening of the cornified layer), and pronounced granular layer and sebacious gland hyperplasia (causing greasy appearance of the hair), were absent in the skin of XpdTTD/†XPCS mice, as established by blind microscopic examination of skin sections (Figure 2B).
T7658 10050-10057 JJ denotes Partial
T7659 10058-10064 NN denotes Rescue
T7660 10065-10067 IN denotes of
T7661 10068-10071 NN denotes TTD
T7662 10072-10081 JJ denotes Cutaneous
T7663 10081-10083 , denotes ,
T7664 10083-10088 NN denotes Blood
T7665 10088-10090 , denotes ,
T7666 10090-10093 CC denotes and
T7667 10094-10107 JJ denotes Developmental
T7668 10108-10118 NNS denotes Phenotypes
T7669 10119-10121 IN denotes in
T7670 10122-10130 NN denotes Compound
T7672 10131-10143 JJ denotes Heterozygous
T7673 10144-10150 NN denotes XpdTTD
T7675 10150-10151 HYPH denotes /
T7674 10151-10156 NN denotes †XPCS
T7671 10157-10161 NNS denotes Mice
T7676 10161-10261 sentence denotes (A) Photographs of 5-mo-old homozygous XpdTTD/TTD, compound heterozygous XpdTTD/†XPCS, and wt mice.
T7677 10162-10163 -LRB- denotes (
T7678 10163-10164 LS denotes A
T7680 10164-10165 -RRB- denotes )
T7679 10166-10177 NNS denotes Photographs
T7681 10178-10180 IN denotes of
T7682 10181-10182 CD denotes 5
T7684 10182-10183 HYPH denotes -
T7683 10183-10185 NN denotes mo
T7686 10185-10186 HYPH denotes -
T7685 10186-10189 JJ denotes old
T7688 10190-10200 JJ denotes homozygous
T7690 10201-10207 NN denotes XpdTTD
T7691 10207-10208 HYPH denotes /
T7689 10208-10211 NN denotes TTD
T7692 10211-10213 , denotes ,
T7693 10213-10221 NN denotes compound
T7695 10222-10234 JJ denotes heterozygous
T7696 10235-10241 NN denotes XpdTTD
T7697 10241-10242 HYPH denotes /
T7694 10242-10247 NN denotes †XPCS
T7698 10247-10249 , denotes ,
T7699 10249-10252 CC denotes and
T7700 10253-10255 NN denotes wt
T7687 10256-10260 NNS denotes mice
T7701 10260-10261 . denotes .
T7702 10261-10302 sentence denotes Insets: images of first-round hair loss.
T7703 10262-10268 NNS denotes Insets
T7704 10268-10270 : denotes :
T7705 10270-10276 NNS denotes images
T7706 10277-10279 IN denotes of
T7707 10280-10285 JJ denotes first
T7709 10285-10286 HYPH denotes -
T7708 10286-10291 NN denotes round
T7711 10292-10296 NN denotes hair
T7710 10297-10301 NN denotes loss
T7712 10301-10302 . denotes .
T7713 10302-10382 sentence denotes (B) Histological analysis of the skin of XpdTTD/TTD, XpdTTD/†XPCS, and wt mice.
T7714 10303-10304 -LRB- denotes (
T7715 10304-10305 LS denotes B
T7717 10305-10306 -RRB- denotes )
T7718 10307-10319 JJ denotes Histological
T7716 10320-10328 NN denotes analysis
T7719 10329-10331 IN denotes of
T7720 10332-10335 DT denotes the
T7721 10336-10340 NN denotes skin
T7722 10341-10343 IN denotes of
T7723 10344-10350 NN denotes XpdTTD
T7725 10350-10351 HYPH denotes /
T7724 10351-10354 NN denotes TTD
T7727 10354-10356 , denotes ,
T7728 10356-10362 NN denotes XpdTTD
T7730 10362-10363 HYPH denotes /
T7729 10363-10368 NN denotes †XPCS
T7731 10368-10370 , denotes ,
T7732 10370-10373 CC denotes and
T7733 10374-10376 NN denotes wt
T7726 10377-10381 NNS denotes mice
T7734 10381-10382 . denotes .
T7735 10382-10638 sentence denotes TTD-associated acanthosis (thicker epidermis, indicated by solid vertical line), pronounced granular layer (indicated by arrows), and sebacious gland hyperplasia (indicated by dotted vertical line) were absent in the epidermis of XpdTTD/†XPCS and wt mice.
T7736 10383-10386 NN denotes TTD
T7738 10386-10387 HYPH denotes -
T7737 10387-10397 JJ denotes associated
T7739 10398-10408 NN denotes acanthosis
T7741 10409-10410 -LRB- denotes (
T7743 10410-10417 JJR denotes thicker
T7742 10418-10427 NN denotes epidermis
T7744 10427-10429 , denotes ,
T7745 10429-10438 VBN denotes indicated
T7746 10439-10441 IN denotes by
T7747 10442-10447 JJ denotes solid
T7749 10448-10456 JJ denotes vertical
T7748 10457-10461 NN denotes line
T7750 10461-10462 -RRB- denotes )
T7751 10462-10464 , denotes ,
T7752 10464-10474 VBN denotes pronounced
T7754 10475-10483 JJ denotes granular
T7753 10484-10489 NN denotes layer
T7755 10490-10491 -LRB- denotes (
T7756 10491-10500 VBN denotes indicated
T7757 10501-10503 IN denotes by
T7758 10504-10510 NNS denotes arrows
T7759 10510-10511 -RRB- denotes )
T7760 10511-10513 , denotes ,
T7761 10513-10516 CC denotes and
T7762 10517-10526 JJ denotes sebacious
T7764 10527-10532 NN denotes gland
T7763 10533-10544 NN denotes hyperplasia
T7765 10545-10546 -LRB- denotes (
T7766 10546-10555 VBN denotes indicated
T7767 10556-10558 IN denotes by
T7768 10559-10565 VBN denotes dotted
T7770 10566-10574 JJ denotes vertical
T7769 10575-10579 NN denotes line
T7771 10579-10580 -RRB- denotes )
T7740 10581-10585 VBD denotes were
T7772 10586-10592 JJ denotes absent
T7773 10593-10595 IN denotes in
T7774 10596-10599 DT denotes the
T7775 10600-10609 NN denotes epidermis
T7776 10610-10612 IN denotes of
T7777 10613-10619 NN denotes XpdTTD
T7779 10619-10620 HYPH denotes /
T7778 10620-10625 NN denotes †XPCS
T7781 10626-10629 CC denotes and
T7782 10630-10632 NN denotes wt
T7780 10633-10637 NNS denotes mice
T7783 10637-10638 . denotes .
T7784 10638-10658 sentence denotes Magnification 400×.
T7785 10639-10652 NN denotes Magnification
T7786 10653-10656 CD denotes 400
T7787 10656-10657 SYM denotes ×
T7788 10657-10658 . denotes .
T7789 10658-10731 sentence denotes (C) Cysteine content of hair from wt, XpdTTD/TTD, and XpdTTD/†XPCS mice.
T7790 10659-10660 -LRB- denotes (
T7791 10660-10661 LS denotes C
T7793 10661-10662 -RRB- denotes )
T7794 10663-10671 NN denotes Cysteine
T7792 10672-10679 NN denotes content
T7795 10680-10682 IN denotes of
T7796 10683-10687 NN denotes hair
T7797 10688-10692 IN denotes from
T7798 10693-10695 NN denotes wt
T7800 10695-10697 , denotes ,
T7801 10697-10703 NN denotes XpdTTD
T7803 10703-10704 HYPH denotes /
T7802 10704-10707 NN denotes TTD
T7804 10707-10709 , denotes ,
T7805 10709-10712 CC denotes and
T7806 10713-10719 NN denotes XpdTTD
T7808 10719-10720 HYPH denotes /
T7807 10720-10725 NN denotes †XPCS
T7799 10726-10730 NNS denotes mice
T7809 10730-10731 . denotes .
T7810 10731-10854 sentence denotes The p-value indicates significant differences between mutants and wt, as well as between XpdTTD/TTD and XpdTTD/†XPCS mice.
T7811 10732-10735 DT denotes The
T7813 10736-10737 NN denotes p
T7814 10737-10738 HYPH denotes -
T7812 10738-10743 NN denotes value
T7815 10744-10753 VBZ denotes indicates
T7816 10754-10765 JJ denotes significant
T7817 10766-10777 NNS denotes differences
T7818 10778-10785 IN denotes between
T7819 10786-10793 NNS denotes mutants
T7820 10794-10797 CC denotes and
T7821 10798-10800 NN denotes wt
T7822 10800-10802 , denotes ,
T7823 10802-10804 RB denotes as
T7825 10805-10809 RB denotes well
T7824 10810-10812 IN denotes as
T7826 10813-10820 IN denotes between
T7827 10821-10827 NN denotes XpdTTD
T7829 10827-10828 HYPH denotes /
T7828 10828-10831 NN denotes TTD
T7831 10832-10835 CC denotes and
T7832 10836-10842 NN denotes XpdTTD
T7834 10842-10843 HYPH denotes /
T7833 10843-10848 NN denotes †XPCS
T7830 10849-10853 NNS denotes mice
T7835 10853-10854 . denotes .
T7836 10854-10908 sentence denotes Error bars indicate standard error of the mean (SEM).
T7837 10855-10860 NN denotes Error
T7838 10861-10865 NNS denotes bars
T7839 10866-10874 VBP denotes indicate
T7840 10875-10883 JJ denotes standard
T7841 10884-10889 NN denotes error
T7842 10890-10892 IN denotes of
T7843 10893-10896 DT denotes the
T7844 10897-10901 NN denotes mean
T7845 10902-10903 -LRB- denotes (
T7846 10903-10906 NN denotes SEM
T7847 10906-10907 -RRB- denotes )
T7848 10907-10908 . denotes .
T7849 10908-10978 sentence denotes (D) Hematocrit values from blood of XpdTTD/TTD and XpdTTD/†XPCS mice.
T7850 10909-10910 -LRB- denotes (
T7851 10910-10911 LS denotes D
T7853 10911-10912 -RRB- denotes )
T7854 10913-10923 NN denotes Hematocrit
T7852 10924-10930 NNS denotes values
T7855 10931-10935 IN denotes from
T7856 10936-10941 NN denotes blood
T7857 10942-10944 IN denotes of
T7858 10945-10951 NN denotes XpdTTD
T7860 10951-10952 HYPH denotes /
T7859 10952-10955 NN denotes TTD
T7862 10956-10959 CC denotes and
T7863 10960-10966 NN denotes XpdTTD
T7865 10966-10967 HYPH denotes /
T7864 10967-10972 NN denotes †XPCS
T7861 10973-10977 NNS denotes mice
T7866 10977-10978 . denotes .
T7867 10978-11051 sentence denotes The p-values indicate the significance of the difference relative to wt.
T7868 10979-10982 DT denotes The
T7870 10983-10984 NN denotes p
T7871 10984-10985 HYPH denotes -
T7869 10985-10991 NNS denotes values
T7872 10992-11000 VBP denotes indicate
T7873 11001-11004 DT denotes the
T7874 11005-11017 NN denotes significance
T7875 11018-11020 IN denotes of
T7876 11021-11024 DT denotes the
T7877 11025-11035 NN denotes difference
T7878 11036-11044 JJ denotes relative
T7879 11045-11047 IN denotes to
T7880 11048-11050 NN denotes wt
T7881 11050-11051 . denotes .
T7882 11051-11076 sentence denotes Error bars indicate SEM.
T7883 11052-11057 NN denotes Error
T7884 11058-11062 NNS denotes bars
T7885 11063-11071 VBP denotes indicate
T7886 11072-11075 NN denotes SEM
T7887 11075-11076 . denotes .
T7888 11076-11267 sentence denotes (E) Body weights of developing XpdTTD/TTD and XpdTTD/†XPCS mice after weaning plotted as a percentage of the weight of age-matched control wt and heterozygote (hz) littermates (set at 100%).
T7889 11077-11078 -LRB- denotes (
T7890 11078-11079 LS denotes E
T7892 11079-11080 -RRB- denotes )
T7893 11081-11085 NN denotes Body
T7891 11086-11093 NNS denotes weights
T7894 11094-11096 IN denotes of
T7895 11097-11107 VBG denotes developing
T7897 11108-11114 NN denotes XpdTTD
T7899 11114-11115 HYPH denotes /
T7898 11115-11118 NN denotes TTD
T7900 11119-11122 CC denotes and
T7901 11123-11129 NN denotes XpdTTD
T7903 11129-11130 HYPH denotes /
T7902 11130-11135 NN denotes †XPCS
T7896 11136-11140 NNS denotes mice
T7904 11141-11146 IN denotes after
T7905 11147-11154 VBG denotes weaning
T7906 11155-11162 VBN denotes plotted
T7907 11163-11165 IN denotes as
T7908 11166-11167 DT denotes a
T7909 11168-11178 NN denotes percentage
T7910 11179-11181 IN denotes of
T7911 11182-11185 DT denotes the
T7912 11186-11192 NN denotes weight
T7913 11193-11195 IN denotes of
T7914 11196-11199 NN denotes age
T7916 11199-11200 HYPH denotes -
T7915 11200-11207 JJ denotes matched
T7918 11208-11215 NN denotes control
T7919 11216-11218 NN denotes wt
T7920 11219-11222 CC denotes and
T7921 11223-11235 NN denotes heterozygote
T7922 11236-11237 -LRB- denotes (
T7923 11237-11239 NN denotes hz
T7924 11239-11240 -RRB- denotes )
T7917 11241-11252 NNS denotes littermates
T7925 11253-11254 -LRB- denotes (
T7926 11254-11257 VBN denotes set
T7927 11258-11260 IN denotes at
T7928 11261-11264 CD denotes 100
T7929 11264-11265 NN denotes %
T7930 11265-11266 -RRB- denotes )
T7931 11266-11267 . denotes .
T7932 11267-11292 sentence denotes Error bars indicate SEM.
T7933 11268-11273 NN denotes Error
T7934 11274-11278 NNS denotes bars
T7935 11279-11287 VBP denotes indicate
T7936 11288-11291 NN denotes SEM
T7937 11291-11292 . denotes .
T2338 11293-11298 JJ denotes Other
T2340 11299-11308 JJ denotes prominent
T2341 11309-11312 NN denotes TTD
T2339 11313-11321 NNS denotes features
T2343 11322-11324 IN denotes in
T2344 11325-11328 DT denotes the
T2345 11329-11338 NN denotes epidermis
T2346 11338-11340 , denotes ,
T2347 11340-11349 VBG denotes including
T2348 11350-11360 NN denotes acanthosis
T2349 11361-11362 -LRB- denotes (
T2350 11362-11372 VBG denotes thickening
T2351 11373-11375 IN denotes of
T2352 11376-11379 DT denotes the
T2353 11380-11385 NN denotes layer
T2354 11386-11388 IN denotes of
T2355 11389-11392 DT denotes the
T2357 11393-11402 JJ denotes nucleated
T2356 11403-11408 NNS denotes cells
T2358 11408-11409 -RRB- denotes )
T2359 11409-11411 , denotes ,
T2360 11411-11425 NN denotes hyperkeratosis
T2361 11426-11427 -LRB- denotes (
T2363 11427-11436 JJ denotes prominent
T2362 11437-11447 NN denotes thickening
T2364 11448-11450 IN denotes of
T2365 11451-11454 DT denotes the
T2367 11455-11464 VBN denotes cornified
T2366 11465-11470 NN denotes layer
T2368 11470-11471 -RRB- denotes )
T2369 11471-11473 , denotes ,
T2370 11473-11476 CC denotes and
T2371 11477-11487 JJ denotes pronounced
T2373 11488-11496 JJ denotes granular
T2372 11497-11502 NN denotes layer
T2374 11503-11506 CC denotes and
T2375 11507-11516 JJ denotes sebacious
T2376 11517-11522 NN denotes gland
T2377 11523-11534 NN denotes hyperplasia
T2378 11535-11536 -LRB- denotes (
T2379 11536-11543 VBG denotes causing
T2380 11544-11550 JJ denotes greasy
T2381 11551-11561 NN denotes appearance
T2382 11562-11564 IN denotes of
T2383 11565-11568 DT denotes the
T2384 11569-11573 NN denotes hair
T2385 11573-11574 -RRB- denotes )
T2386 11574-11576 , denotes ,
T2342 11576-11580 VBD denotes were
T2387 11581-11587 JJ denotes absent
T2388 11588-11590 IN denotes in
T2389 11591-11594 DT denotes the
T2390 11595-11599 NN denotes skin
T2391 11600-11602 IN denotes of
T2392 11603-11609 NN denotes XpdTTD
T2394 11609-11610 HYPH denotes /
T2393 11610-11615 NN denotes †XPCS
T2395 11616-11620 NNS denotes mice
T2396 11620-11622 , denotes ,
T2397 11622-11624 IN denotes as
T2398 11625-11636 VBN denotes established
T2399 11637-11639 IN denotes by
T2400 11640-11645 JJ denotes blind
T2402 11646-11657 JJ denotes microscopic
T2401 11658-11669 NN denotes examination
T2403 11670-11672 IN denotes of
T2404 11673-11677 NN denotes skin
T2405 11678-11686 NNS denotes sections
T2406 11687-11688 -LRB- denotes (
T2408 11688-11694 NN denotes Figure
T2407 11695-11697 NN denotes 2B
T2409 11697-11698 -RRB- denotes )
T2410 11698-11699 . denotes .
T2411 11699-11897 sentence denotes Furthermore, anaemia and developmental delay present in patients with TTD [24] and in XpdTTD/TTD mice [15] were both partially rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 2D and 2E).
T2412 11700-11711 RB denotes Furthermore
T2414 11711-11713 , denotes ,
T2415 11713-11720 NN denotes anaemia
T2416 11721-11724 CC denotes and
T2417 11725-11738 JJ denotes developmental
T2418 11739-11744 NN denotes delay
T2419 11745-11752 JJ denotes present
T2420 11753-11755 IN denotes in
T2421 11756-11764 NNS denotes patients
T2422 11765-11769 IN denotes with
T2423 11770-11773 NN denotes TTD
T2424 11774-11775 -LRB- denotes [
T2425 11775-11777 CD denotes 24
T2426 11777-11778 -RRB- denotes ]
T2427 11779-11782 CC denotes and
T2428 11783-11785 IN denotes in
T2429 11786-11792 NN denotes XpdTTD
T2431 11792-11793 HYPH denotes /
T2430 11793-11796 NN denotes TTD
T2432 11797-11801 NNS denotes mice
T2433 11802-11803 -LRB- denotes [
T2434 11803-11805 CD denotes 15
T2435 11805-11806 -RRB- denotes ]
T2436 11807-11811 VBD denotes were
T2437 11812-11816 RB denotes both
T2438 11817-11826 RB denotes partially
T2413 11827-11834 VBN denotes rescued
T2439 11835-11837 IN denotes in
T2440 11838-11846 JJ denotes compound
T2442 11847-11859 JJ denotes heterozygous
T2443 11860-11866 NN denotes XpdTTD
T2445 11866-11867 HYPH denotes /
T2444 11867-11872 NN denotes †XPCS
T2441 11873-11877 NNS denotes mice
T2446 11878-11879 -LRB- denotes (
T2448 11879-11885 NN denotes Figure
T2447 11886-11888 NN denotes 2D
T2449 11889-11892 CC denotes and
T2450 11893-11895 NN denotes 2E
T2451 11895-11896 -RRB- denotes )
T2452 11896-11897 . denotes .
T2575 11919-11927 NNS denotes Features
T2576 11928-11930 IN denotes in
T2577 11931-11934 NN denotes TTD
T2578 11935-11939 NNS denotes Mice
T2579 11940-11942 IN denotes by
T2580 11943-11953 JJ denotes Homozygous
T2582 11954-11960 JJ denotes Lethal
T2583 11961-11964 NN denotes Xpd
T2581 11965-11972 NNS denotes Alleles
T2584 11972-12206 sentence denotes Because patients with TTD, XPCS, and CS (but not XP) and the corresponding mouse models share similar accelerated progeroid symptoms [12,13,15,23], we next addressed ageing-related parameters in compound heterozygous mice (Figure 3).
T2585 11973-11980 IN denotes Because
T2587 11981-11989 NNS denotes patients
T2588 11990-11994 IN denotes with
T2589 11995-11998 NN denotes TTD
T2590 11998-12000 , denotes ,
T2591 12000-12004 NN denotes XPCS
T2592 12004-12006 , denotes ,
T2593 12006-12009 CC denotes and
T2594 12010-12012 NN denotes CS
T2595 12013-12014 -LRB- denotes (
T2596 12014-12017 CC denotes but
T2597 12018-12021 RB denotes not
T2598 12022-12024 NN denotes XP
T2599 12024-12025 -RRB- denotes )
T2600 12026-12029 CC denotes and
T2601 12030-12033 DT denotes the
T2603 12034-12047 VBG denotes corresponding
T2604 12048-12053 NN denotes mouse
T2602 12054-12060 NNS denotes models
T2586 12061-12066 VBP denotes share
T2606 12067-12074 JJ denotes similar
T2608 12075-12086 VBN denotes accelerated
T2609 12087-12096 NN denotes progeroid
T2607 12097-12105 NNS denotes symptoms
T2610 12106-12107 -LRB- denotes [
T2612 12107-12109 CD denotes 12
T2613 12109-12110 , denotes ,
T2614 12110-12112 CD denotes 13
T2615 12112-12113 , denotes ,
T2616 12113-12115 CD denotes 15
T2617 12115-12116 , denotes ,
T2611 12116-12118 CD denotes 23
T2618 12118-12119 -RRB- denotes ]
T2619 12119-12121 , denotes ,
T2620 12121-12123 PRP denotes we
T2621 12124-12128 RB denotes next
T2605 12129-12138 VBD denotes addressed
T2622 12139-12145 JJ denotes ageing
T2624 12145-12146 HYPH denotes -
T2623 12146-12153 JJ denotes related
T2625 12154-12164 NNS denotes parameters
T2626 12165-12167 IN denotes in
T2627 12168-12176 JJ denotes compound
T2629 12177-12189 JJ denotes heterozygous
T2628 12190-12194 NNS denotes mice
T2630 12195-12196 -LRB- denotes (
T2631 12196-12202 NN denotes Figure
T2632 12203-12204 CD denotes 3
T2633 12204-12205 -RRB- denotes )
T2634 12205-12206 . denotes .
T2635 12206-12469 sentence denotes Whereas XpdTTD/TTD animals show reduced bone mineral density as an indication of the early onset of osteoporosis before ~14 mo of age [15], tail vertebrae from compound heterozygous XpdTTD/†XPCS mice were comparable to wt even at 20 mo of age (Figure 3B and 3C).
T2636 12207-12214 IN denotes Whereas
T2638 12215-12221 NN denotes XpdTTD
T2640 12221-12222 HYPH denotes /
T2639 12222-12225 NN denotes TTD
T2641 12226-12233 NNS denotes animals
T2637 12234-12238 VBP denotes show
T2643 12239-12246 VBN denotes reduced
T2645 12247-12251 NN denotes bone
T2646 12252-12259 NN denotes mineral
T2644 12260-12267 NN denotes density
T2647 12268-12270 IN denotes as
T2648 12271-12273 DT denotes an
T2649 12274-12284 NN denotes indication
T2650 12285-12287 IN denotes of
T2651 12288-12291 DT denotes the
T2653 12292-12297 JJ denotes early
T2652 12298-12303 NN denotes onset
T2654 12304-12306 IN denotes of
T2655 12307-12319 NN denotes osteoporosis
T2656 12320-12326 IN denotes before
T2657 12327-12328 SYM denotes ~
T2658 12328-12330 CD denotes 14
T2659 12331-12333 NNS denotes mo
T2660 12334-12336 IN denotes of
T2661 12337-12340 NN denotes age
T2662 12341-12342 -LRB- denotes [
T2663 12342-12344 CD denotes 15
T2664 12344-12345 -RRB- denotes ]
T2665 12345-12347 , denotes ,
T2666 12347-12351 NN denotes tail
T2667 12352-12361 NNS denotes vertebrae
T2668 12362-12366 IN denotes from
T2669 12367-12375 NN denotes compound
T2671 12376-12388 JJ denotes heterozygous
T2672 12389-12395 NN denotes XpdTTD
T2674 12395-12396 HYPH denotes /
T2673 12396-12401 NN denotes †XPCS
T2670 12402-12406 NNS denotes mice
T2642 12407-12411 VBD denotes were
T2675 12412-12422 JJ denotes comparable
T2676 12423-12425 IN denotes to
T2677 12426-12428 NN denotes wt
T2678 12429-12433 RB denotes even
T2679 12434-12436 IN denotes at
T2680 12437-12439 CD denotes 20
T2681 12440-12442 NNS denotes mo
T2682 12443-12445 IN denotes of
T2683 12446-12449 NN denotes age
T2684 12450-12451 -LRB- denotes (
T2686 12451-12457 NN denotes Figure
T2685 12458-12460 NN denotes 3B
T2687 12461-12464 CC denotes and
T2688 12465-12467 NN denotes 3C
T2689 12467-12468 -RRB- denotes )
T2690 12468-12469 . denotes .
T2691 12469-12641 sentence denotes Furthermore, whereas XpdTTD/TTD mice developed kyphosis earlier than wt animals (onset ~3 mo versus 12–20 mo), compound heterozygous XpdTTD/†XPCS mice did not (Figure 3B).
T2692 12470-12481 RB denotes Furthermore
T2694 12481-12483 , denotes ,
T2695 12483-12490 IN denotes whereas
T2697 12491-12497 NN denotes XpdTTD
T2699 12497-12498 HYPH denotes /
T2698 12498-12501 NN denotes TTD
T2700 12502-12506 NNS denotes mice
T2696 12507-12516 VBD denotes developed
T2701 12517-12525 NN denotes kyphosis
T2702 12526-12533 RBR denotes earlier
T2703 12534-12538 IN denotes than
T2704 12539-12541 NN denotes wt
T2705 12542-12549 NNS denotes animals
T2706 12550-12551 -LRB- denotes (
T2707 12551-12556 NN denotes onset
T2708 12557-12558 SYM denotes ~
T2709 12558-12559 CD denotes 3
T2710 12560-12562 NNS denotes mo
T2711 12563-12569 CC denotes versus
T2712 12570-12572 CD denotes 12
T2714 12572-12573 SYM denotes –
T2713 12573-12575 CD denotes 20
T2715 12576-12578 NNS denotes mo
T2716 12578-12579 -RRB- denotes )
T2717 12579-12581 , denotes ,
T2718 12581-12589 JJ denotes compound
T2720 12590-12602 JJ denotes heterozygous
T2721 12603-12609 NN denotes XpdTTD
T2723 12609-12610 HYPH denotes /
T2722 12610-12615 NN denotes †XPCS
T2719 12616-12620 NNS denotes mice
T2724 12621-12624 VBD denotes did
T2725 12625-12628 RB denotes not
T2726 12629-12630 -LRB- denotes (
T2727 12630-12636 NN denotes Figure
T2693 12637-12639 NN denotes 3B
T2728 12639-12640 -RRB- denotes )
T2729 12640-12641 . denotes .
T2730 12641-12853 sentence denotes Overall appearance and body weight curves revealed that TTD-associated age-related premature cachexia and lack of general fitness were fully rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 3A and 3D).
T2731 12642-12649 JJ denotes Overall
T2732 12650-12660 NN denotes appearance
T2734 12661-12664 CC denotes and
T2735 12665-12669 NN denotes body
T2736 12670-12676 NN denotes weight
T2737 12677-12683 NNS denotes curves
T2733 12684-12692 VBD denotes revealed
T2738 12693-12697 IN denotes that
T2740 12698-12701 NN denotes TTD
T2742 12701-12702 HYPH denotes -
T2741 12702-12712 JJ denotes associated
T2744 12713-12716 NN denotes age
T2746 12716-12717 HYPH denotes -
T2745 12717-12724 JJ denotes related
T2747 12725-12734 JJ denotes premature
T2743 12735-12743 NN denotes cachexia
T2748 12744-12747 CC denotes and
T2749 12748-12752 NN denotes lack
T2750 12753-12755 IN denotes of
T2751 12756-12763 JJ denotes general
T2752 12764-12771 NN denotes fitness
T2753 12772-12776 VBD denotes were
T2754 12777-12782 RB denotes fully
T2739 12783-12790 VBN denotes rescued
T2755 12791-12793 IN denotes in
T2756 12794-12802 JJ denotes compound
T2758 12803-12815 JJ denotes heterozygous
T2759 12816-12822 NN denotes XpdTTD
T2761 12822-12823 HYPH denotes /
T2760 12823-12828 NN denotes †XPCS
T2757 12829-12833 NNS denotes mice
T2762 12834-12835 -LRB- denotes (
T2764 12835-12841 NN denotes Figure
T2763 12842-12844 NN denotes 3A
T2765 12845-12848 CC denotes and
T2766 12849-12851 NN denotes 3D
T2767 12851-12852 -RRB- denotes )
T2768 12852-12853 . denotes .
T2769 12853-12954 sentence denotes Finally, the life span of compound heterozygotes was extended relative to XpdTTD/TTD mice (Table 2).
T2770 12854-12861 RB denotes Finally
T2772 12861-12863 , denotes ,
T2773 12863-12866 DT denotes the
T2775 12867-12871 NN denotes life
T2774 12872-12876 NN denotes span
T2776 12877-12879 IN denotes of
T2777 12880-12888 JJ denotes compound
T2778 12889-12902 NNS denotes heterozygotes
T2779 12903-12906 VBD denotes was
T2771 12907-12915 VBN denotes extended
T2780 12916-12924 JJ denotes relative
T2781 12925-12927 IN denotes to
T2782 12928-12934 NN denotes XpdTTD
T2784 12934-12935 HYPH denotes /
T2783 12935-12938 NN denotes TTD
T2785 12939-12943 NNS denotes mice
T2786 12944-12945 -LRB- denotes (
T2787 12945-12950 NN denotes Table
T2788 12951-12952 CD denotes 2
T2789 12952-12953 -RRB- denotes )
T2790 12953-12954 . denotes .
T2791 12954-14564 sentence denotes Figure 3 Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice (A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice. (B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse. (C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM. (D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. Table 2 Pleiotropic Xpd Biallelic Effects in Mice and Cells To determine whether the homozygous lethal Xpd†XPCS allele was unique in its ability to ameliorate symptoms associated with the XpdTTD allele, we generated compound heterozygous XpdTTD/†XP mice by crossing the corresponding heterozygous animals.
T8041 12965-12971 NN denotes Rescue
T8042 12972-12974 IN denotes of
T8043 12975-12978 NN denotes TTD
T8045 12978-12979 HYPH denotes -
T8044 12979-12989 JJ denotes Associated
T8047 12990-12999 JJ denotes Segmental
T8048 13000-13009 JJ denotes Progeroid
T8046 13010-13018 NNS denotes Features
T8049 13019-13021 IN denotes in
T8050 13022-13030 JJ denotes Compound
T8052 13031-13043 JJ denotes Heterozygous
T8053 13044-13051 NN denotes Xpd TTD
T8055 13051-13052 HYPH denotes /
T8054 13052-13057 NN denotes †XPCS
T8051 13058-13062 NNS denotes Mice
T8056 13062-13163 sentence denotes (A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice.
T8057 13063-13064 -LRB- denotes (
T8058 13064-13065 LS denotes A
T8060 13065-13066 -RRB- denotes )
T8059 13067-13078 NNS denotes Photographs
T8061 13079-13081 IN denotes of
T8062 13082-13084 CD denotes 20
T8064 13084-13085 HYPH denotes -
T8063 13085-13087 NN denotes mo
T8066 13087-13088 HYPH denotes -
T8065 13088-13091 JJ denotes old
T8068 13092-13094 NN denotes wt
T8069 13094-13096 , denotes ,
T8070 13096-13104 JJ denotes compound
T8072 13105-13117 JJ denotes heterozygous
T8073 13118-13124 NN denotes XpdTTD
T8074 13124-13125 HYPH denotes /
T8071 13125-13130 NN denotes †XPCS
T8075 13130-13132 , denotes ,
T8076 13132-13135 CC denotes and
T8077 13136-13146 JJ denotes homozygous
T8079 13147-13153 NN denotes XpdTTD
T8080 13153-13154 HYPH denotes /
T8078 13154-13157 NN denotes TTD
T8067 13158-13162 NNS denotes mice
T8081 13162-13163 . denotes .
T8082 13163-13303 sentence denotes Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.
T8083 13164-13168 VB denotes Note
T8084 13169-13172 DT denotes the
T8086 13173-13180 JJ denotes extreme
T8085 13181-13189 NN denotes cachexia
T8087 13190-13191 -LRB- denotes (
T8088 13191-13195 NN denotes lack
T8089 13196-13198 IN denotes of
T8090 13199-13211 JJ denotes subcutaneous
T8091 13212-13215 NN denotes fat
T8092 13215-13216 -RRB- denotes )
T8093 13217-13219 IN denotes in
T8094 13220-13223 DT denotes the
T8096 13224-13230 NN denotes XpdTTD
T8098 13230-13231 HYPH denotes /
T8097 13231-13234 NN denotes TTD
T8095 13235-13240 NN denotes mouse
T8099 13241-13244 CC denotes and
T8100 13245-13248 DT denotes the
T8101 13249-13256 NN denotes absence
T8102 13257-13259 IN denotes of
T8103 13260-13264 DT denotes this
T8104 13265-13274 NN denotes phenotype
T8105 13275-13277 IN denotes in
T8106 13278-13280 NN denotes wt
T8108 13281-13284 CC denotes and
T8109 13285-13291 NN denotes XpdTTD
T8111 13291-13292 HYPH denotes /
T8110 13292-13297 NN denotes †XPCS
T8107 13298-13302 NNS denotes mice
T8112 13302-13303 . denotes .
T8113 13303-13376 sentence denotes (B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice.
T8114 13304-13305 -LRB- denotes (
T8115 13305-13306 LS denotes B
T8117 13306-13307 -RRB- denotes )
T8116 13308-13319 NNS denotes Radiographs
T8118 13320-13322 IN denotes of
T8119 13323-13325 CD denotes 20
T8121 13325-13326 HYPH denotes -
T8120 13326-13328 NN denotes mo
T8123 13328-13329 HYPH denotes -
T8122 13329-13332 JJ denotes old
T8125 13333-13337 JJ denotes male
T8126 13338-13340 NN denotes wt
T8127 13340-13342 , denotes ,
T8128 13342-13348 NN denotes XpdTTD
T8130 13348-13349 HYPH denotes /
T8129 13349-13354 NN denotes †XPCS
T8131 13354-13356 , denotes ,
T8132 13356-13359 CC denotes and
T8133 13360-13366 NN denotes XpdTTD
T8135 13366-13367 HYPH denotes /
T8134 13367-13370 NN denotes TTD
T8124 13371-13375 NNS denotes mice
T8136 13375-13376 . denotes .
T8137 13376-13586 sentence denotes Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right).
T8138 13377-13383 VBG denotes Ageing
T8140 13384-13390 NN denotes XpdTTD
T8142 13390-13391 HYPH denotes /
T8141 13391-13394 NN denotes TTD
T8139 13395-13399 NNS denotes mice
T8143 13400-13407 VBP denotes develop
T8144 13408-13416 NN denotes kyphosis
T8145 13417-13418 -LRB- denotes (
T8146 13418-13427 NN denotes curvature
T8147 13428-13430 IN denotes of
T8148 13431-13434 DT denotes the
T8150 13435-13441 JJ denotes spinal
T8149 13442-13448 NN denotes column
T8151 13448-13449 -RRB- denotes )
T8152 13450-13453 CC denotes and
T8153 13454-13463 NN denotes reduction
T8154 13464-13466 IN denotes of
T8155 13467-13471 NN denotes bone
T8156 13472-13479 NN denotes mineral
T8157 13480-13487 NN denotes density
T8158 13488-13490 IN denotes as
T8159 13491-13496 VBN denotes shown
T8160 13497-13499 IN denotes in
T8161 13500-13503 DT denotes the
T8163 13504-13505 CD denotes 6
T8165 13505-13506 SYM denotes –
T8164 13506-13507 CD denotes 8
T8162 13508-13515 NN denotes segment
T8166 13516-13518 IN denotes of
T8167 13519-13522 DT denotes the
T8169 13523-13527 NN denotes tail
T8168 13528-13537 NNS denotes vertebrae
T8170 13538-13545 VBN denotes counted
T8171 13546-13550 IN denotes from
T8172 13551-13554 DT denotes the
T8173 13555-13561 NN denotes pelvis
T8174 13562-13563 -LRB- denotes (
T8175 13563-13566 VB denotes see
T8176 13567-13572 JJ denotes close
T8177 13572-13573 HYPH denotes -
T8178 13573-13575 RP denotes up
T8179 13576-13578 IN denotes at
T8180 13579-13584 NN denotes right
T8181 13584-13585 -RRB- denotes )
T8182 13585-13586 . denotes .
T8183 13586-13651 sentence denotes Note the absence of these features in the XpdTTD / † XPCS mouse.
T8184 13587-13591 VB denotes Note
T8185 13592-13595 DT denotes the
T8186 13596-13603 NN denotes absence
T8187 13604-13606 IN denotes of
T8188 13607-13612 DT denotes these
T8189 13613-13621 NNS denotes features
T8190 13622-13624 IN denotes in
T8191 13625-13628 DT denotes the
T8193 13629-13636 NN denotes XpdTTD 
T8195 13636-13637 HYPH denotes /
T8194 13637-13644 NN denotes  † XPCS
T8192 13645-13650 NN denotes mouse
T8196 13650-13651 . denotes .
T8197 13651-13804 sentence denotes (C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice.
T8198 13652-13653 -LRB- denotes (
T8199 13653-13654 LS denotes C
T8201 13654-13655 -RRB- denotes )
T8200 13656-13670 NN denotes Quantification
T8202 13671-13673 IN denotes of
T8203 13674-13682 JJ denotes relative
T8205 13683-13687 NN denotes bone
T8206 13688-13695 NN denotes mineral
T8204 13696-13703 NN denotes density
T8207 13704-13706 IN denotes of
T8208 13707-13711 NN denotes tail
T8209 13712-13721 NNS denotes vertebrae
T8210 13722-13726 IN denotes from
T8211 13727-13729 CD denotes 20
T8213 13729-13730 HYPH denotes -
T8212 13730-13732 NN denotes mo
T8215 13732-13733 HYPH denotes -
T8214 13733-13736 JJ denotes old
T8217 13737-13741 JJ denotes male
T8218 13742-13744 NN denotes wt
T8219 13745-13746 -LRB- denotes (
T8221 13746-13747 NN denotes n
T8222 13748-13749 SYM denotes =
T8220 13750-13751 CD denotes 3
T8223 13751-13752 -RRB- denotes )
T8224 13752-13754 , denotes ,
T8225 13754-13760 NN denotes XpdTTD
T8227 13760-13761 HYPH denotes /
T8226 13761-13766 NN denotes †XPCS
T8228 13767-13768 -LRB- denotes (
T8230 13768-13769 NN denotes n
T8231 13770-13771 SYM denotes =
T8229 13772-13773 CD denotes 4
T8232 13773-13774 -RRB- denotes )
T8233 13774-13776 , denotes ,
T8234 13776-13779 CC denotes and
T8235 13780-13786 NN denotes XpdTTD
T8237 13786-13787 HYPH denotes /
T8236 13787-13790 NN denotes TTD
T8238 13791-13792 -LRB- denotes (
T8240 13792-13793 NN denotes n
T8241 13794-13795 SYM denotes =
T8239 13796-13797 CD denotes 3
T8242 13797-13798 -RRB- denotes )
T8216 13799-13803 NNS denotes mice
T8243 13803-13804 . denotes .
T8244 13804-13885 sentence denotes The p-values indicate the significance of the difference relative to XpdTTD/TTD.
T8245 13805-13808 DT denotes The
T8247 13809-13810 NN denotes p
T8248 13810-13811 HYPH denotes -
T8246 13811-13817 NNS denotes values
T8249 13818-13826 VBP denotes indicate
T8250 13827-13830 DT denotes the
T8251 13831-13843 NN denotes significance
T8252 13844-13846 IN denotes of
T8253 13847-13850 DT denotes the
T8254 13851-13861 NN denotes difference
T8255 13862-13870 JJ denotes relative
T8256 13871-13873 IN denotes to
T8257 13874-13880 NN denotes XpdTTD
T8259 13880-13881 HYPH denotes /
T8258 13881-13884 NN denotes TTD
T8260 13884-13885 . denotes .
T8261 13885-13910 sentence denotes Error bars indicate SEM.
T8262 13886-13891 NN denotes Error
T8263 13892-13896 NNS denotes bars
T8264 13897-13905 VBP denotes indicate
T8265 13906-13909 NN denotes SEM
T8266 13909-13910 . denotes .
T8267 13910-13956 sentence denotes (D) Body weight curves as a function of time.
T8268 13911-13912 -LRB- denotes (
T8269 13912-13913 LS denotes D
T8271 13913-13914 -RRB- denotes )
T8272 13915-13919 NN denotes Body
T8273 13920-13926 NN denotes weight
T8270 13927-13933 NNS denotes curves
T8274 13934-13936 IN denotes as
T8275 13937-13938 DT denotes a
T8276 13939-13947 NN denotes function
T8277 13948-13950 IN denotes of
T8278 13951-13955 NN denotes time
T8279 13955-13956 . denotes .
T8280 13956-14078 sentence denotes Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice.
T8281 13957-13961 VB denotes Note
T8282 13962-13966 IN denotes that
T8284 13967-13970 DT denotes the
T8286 13971-13974 NN denotes age
T8288 13974-13975 HYPH denotes -
T8287 13975-13984 JJ denotes dependent
T8285 13985-13993 NN denotes cachexia
T8289 13994-14002 VBN denotes observed
T8290 14003-14005 IN denotes in
T8291 14006-14012 NN denotes XpdTTD
T8293 14012-14013 HYPH denotes /
T8292 14013-14016 NN denotes TTD
T8294 14017-14021 NNS denotes mice
T8295 14022-14025 VBD denotes was
T8283 14026-14033 VBN denotes rescued
T8296 14034-14036 IN denotes in
T8297 14037-14041 CC denotes both
T8298 14042-14046 JJ denotes male
T8300 14047-14050 CC denotes and
T8301 14051-14057 JJ denotes female
T8302 14058-14065 NN denotes XpdTTD 
T8304 14065-14066 HYPH denotes /
T8303 14066-14072 NN denotes  †XPCS
T8299 14073-14077 NNS denotes mice
T8305 14077-14078 . denotes .
T8306 14078-14232 sentence denotes Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks.
T8307 14079-14090 JJ denotes Significant
T8308 14091-14102 NNS denotes differences
T8310 14103-14110 IN denotes between
T8311 14111-14113 NN denotes wt
T8312 14114-14117 CC denotes and
T8313 14118-14124 NN denotes XpdTTD
T8315 14124-14125 HYPH denotes /
T8314 14125-14128 NN denotes TTD
T8316 14129-14132 CC denotes but
T8317 14133-14136 RB denotes not
T8318 14137-14144 IN denotes between
T8319 14145-14147 NN denotes wt
T8321 14148-14151 CC denotes and
T8322 14152-14158 NN denotes XpdTTD
T8324 14158-14159 HYPH denotes /
T8323 14159-14164 NN denotes †XPCS
T8320 14165-14169 NNS denotes mice
T8325 14170-14174 VBD denotes were
T8309 14175-14183 VBN denotes observed
T8326 14184-14186 IN denotes at
T8327 14187-14188 CD denotes 9
T8329 14189-14192 CC denotes and
T8330 14193-14195 CD denotes 18
T8328 14196-14198 NNS denotes mo
T8331 14199-14201 IN denotes of
T8332 14202-14205 NN denotes age
T8333 14206-14208 IN denotes as
T8334 14209-14218 VBN denotes indicated
T8335 14219-14221 IN denotes by
T8336 14222-14231 NNS denotes asterisks
T8337 14231-14232 . denotes .
T8338 14232-14257 sentence denotes Error bars indicate SEM.
T8339 14233-14238 NN denotes Error
T8340 14239-14243 NNS denotes bars
T8341 14244-14252 VBP denotes indicate
T8342 14253-14256 NN denotes SEM
T8343 14256-14257 . denotes .
T9241 14267-14278 JJ denotes Pleiotropic
T9243 14279-14282 NN denotes Xpd
T9244 14283-14292 JJ denotes Biallelic
T9242 14293-14300 NNS denotes Effects
T9245 14301-14303 IN denotes in
T9246 14304-14308 NNS denotes Mice
T9247 14309-14312 CC denotes and
T9248 14313-14318 NNS denotes Cells
T2792 14319-14321 TO denotes To
T2793 14322-14331 VB denotes determine
T2795 14332-14339 IN denotes whether
T2797 14340-14343 DT denotes the
T2799 14344-14354 JJ denotes homozygous
T2800 14355-14361 JJ denotes lethal
T2801 14362-14370 NN denotes Xpd†XPCS
T2798 14371-14377 NN denotes allele
T2796 14378-14381 VBD denotes was
T2802 14382-14388 JJ denotes unique
T2803 14389-14391 IN denotes in
T2804 14392-14395 PRP$ denotes its
T2805 14396-14403 NN denotes ability
T2806 14404-14406 TO denotes to
T2807 14407-14417 VB denotes ameliorate
T2808 14418-14426 NNS denotes symptoms
T2809 14427-14437 VBN denotes associated
T2810 14438-14442 IN denotes with
T2811 14443-14446 DT denotes the
T2813 14447-14453 NN denotes XpdTTD
T2812 14454-14460 NN denotes allele
T2814 14460-14462 , denotes ,
T2815 14462-14464 PRP denotes we
T2794 14465-14474 VBD denotes generated
T2816 14475-14483 NN denotes compound
T2818 14484-14496 JJ denotes heterozygous
T2819 14497-14503 NN denotes XpdTTD
T2821 14503-14504 HYPH denotes /
T2820 14504-14507 NN denotes †XP
T2817 14508-14512 NNS denotes mice
T2822 14513-14515 IN denotes by
T2823 14516-14524 VBG denotes crossing
T2824 14525-14528 DT denotes the
T2826 14529-14542 VBG denotes corresponding
T2827 14543-14555 JJ denotes heterozygous
T2825 14556-14563 NNS denotes animals
T2828 14563-14564 . denotes .
T2829 14564-15010 sentence denotes Similar to the Xpd †XPCS allele, the homozygous lethal Xpd †XP allele rescued cutaneous symptoms including hair loss (except locally during the first round; unpublished data), reduced cysteine content (cysteine index 9.3 ± 0.9 standard deviation [87% of wt], p = 0.01 versus TTD), ageing-associated premature cachexia (males and females were 36.1 ± 6.4 g [93% of wt] and 39.2 ± 3.2 g [116% of wt], respectively), and reduced life span (Table 2).
T2830 14565-14572 JJ denotes Similar
T2832 14573-14575 IN denotes to
T2833 14576-14579 DT denotes the
T2835 14580-14589 NN denotes Xpd †XPCS
T2834 14590-14596 NN denotes allele
T2836 14596-14598 , denotes ,
T2837 14598-14601 DT denotes the
T2839 14602-14612 JJ denotes homozygous
T2840 14613-14619 JJ denotes lethal
T2841 14620-14627 NN denotes Xpd †XP
T2838 14628-14634 NN denotes allele
T2831 14635-14642 VBD denotes rescued
T2842 14643-14652 JJ denotes cutaneous
T2843 14653-14661 NNS denotes symptoms
T2844 14662-14671 VBG denotes including
T2845 14672-14676 NN denotes hair
T2846 14677-14681 NN denotes loss
T2847 14682-14683 -LRB- denotes (
T2849 14683-14689 IN denotes except
T2850 14690-14697 RB denotes locally
T2851 14698-14704 IN denotes during
T2852 14705-14708 DT denotes the
T2854 14709-14714 JJ denotes first
T2853 14715-14720 NN denotes round
T2855 14720-14721 : denotes ;
T2856 14722-14733 JJ denotes unpublished
T2848 14734-14738 NNS denotes data
T2857 14738-14739 -RRB- denotes )
T2858 14739-14741 , denotes ,
T2859 14741-14748 VBN denotes reduced
T2861 14749-14757 NN denotes cysteine
T2860 14758-14765 NN denotes content
T2862 14766-14767 -LRB- denotes (
T2864 14767-14775 NN denotes cysteine
T2863 14776-14781 NN denotes index
T2865 14782-14785 CD denotes 9.3
T2866 14786-14787 SYM denotes ±
T2867 14788-14791 CD denotes 0.9
T2869 14792-14800 JJ denotes standard
T2868 14801-14810 NN denotes deviation
T2870 14811-14812 -LRB- denotes [
T2872 14812-14814 CD denotes 87
T2871 14814-14815 NN denotes %
T2873 14816-14818 IN denotes of
T2874 14819-14821 NN denotes wt
T2875 14821-14822 -RRB- denotes ]
T2876 14822-14824 , denotes ,
T2877 14824-14825 NN denotes p
T2879 14826-14827 SYM denotes =
T2880 14828-14832 CD denotes 0.01
T2881 14833-14839 CC denotes versus
T2878 14840-14843 NN denotes TTD
T2882 14843-14844 -RRB- denotes )
T2883 14844-14846 , denotes ,
T2884 14846-14852 NN denotes ageing
T2886 14852-14853 HYPH denotes -
T2885 14853-14863 VBN denotes associated
T2888 14864-14873 JJ denotes premature
T2887 14874-14882 NN denotes cachexia
T2889 14883-14884 -LRB- denotes (
T2891 14884-14889 NNS denotes males
T2892 14890-14893 CC denotes and
T2893 14894-14901 NNS denotes females
T2890 14902-14906 VBD denotes were
T2894 14907-14911 CD denotes 36.1
T2896 14912-14913 SYM denotes ±
T2895 14914-14917 CD denotes 6.4
T2897 14918-14919 NNS denotes g
T2898 14920-14921 -LRB- denotes [
T2900 14921-14923 CD denotes 93
T2899 14923-14924 NN denotes %
T2901 14925-14927 IN denotes of
T2902 14928-14930 NN denotes wt
T2903 14930-14931 -RRB- denotes ]
T2904 14932-14935 CC denotes and
T2905 14936-14940 CD denotes 39.2
T2907 14941-14942 SYM denotes ±
T2906 14943-14946 CD denotes 3.2
T2908 14947-14948 NNS denotes g
T2909 14949-14950 -LRB- denotes [
T2911 14950-14953 CD denotes 116
T2910 14953-14954 NN denotes %
T2912 14955-14957 IN denotes of
T2913 14958-14960 NN denotes wt
T2914 14960-14961 -RRB- denotes ]
T2915 14961-14963 , denotes ,
T2916 14963-14975 RB denotes respectively
T2917 14975-14976 -RRB- denotes )
T2918 14976-14978 , denotes ,
T2919 14978-14981 CC denotes and
T2920 14982-14989 VBN denotes reduced
T2922 14990-14994 NN denotes life
T2921 14995-14999 NN denotes span
T2923 15000-15001 -LRB- denotes (
T2924 15001-15006 NN denotes Table
T2925 15007-15008 CD denotes 2
T2926 15008-15009 -RRB- denotes )
T2927 15009-15010 . denotes .
T2928 15010-15219 sentence denotes Taken together, these data indicate that two independent alleles, which on their own are unable to support viability (Table 1), were nonetheless able to ameliorate TTD-associated phenotypes in vivo (Table 2).
T2929 15011-15016 VBN denotes Taken
T2931 15017-15025 RB denotes together
T2932 15025-15027 , denotes ,
T2933 15027-15032 DT denotes these
T2934 15033-15037 NNS denotes data
T2930 15038-15046 VBP denotes indicate
T2935 15047-15051 IN denotes that
T2937 15052-15055 CD denotes two
T2939 15056-15067 JJ denotes independent
T2938 15068-15075 NNS denotes alleles
T2940 15075-15077 , denotes ,
T2941 15077-15082 WDT denotes which
T2943 15083-15085 IN denotes on
T2944 15086-15091 PRP$ denotes their
T2945 15092-15095 NN denotes own
T2942 15096-15099 VBP denotes are
T2946 15100-15106 JJ denotes unable
T2947 15107-15109 TO denotes to
T2948 15110-15117 VB denotes support
T2949 15118-15127 NN denotes viability
T2950 15128-15129 -LRB- denotes (
T2951 15129-15134 NN denotes Table
T2952 15135-15136 CD denotes 1
T2953 15136-15137 -RRB- denotes )
T2954 15137-15139 , denotes ,
T2936 15139-15143 VBD denotes were
T2955 15144-15155 RB denotes nonetheless
T2956 15156-15160 JJ denotes able
T2957 15161-15163 TO denotes to
T2958 15164-15174 VB denotes ameliorate
T2959 15175-15178 NN denotes TTD
T2961 15178-15179 HYPH denotes -
T2960 15179-15189 VBN denotes associated
T2962 15190-15200 NNS denotes phenotypes
T2963 15201-15203 FW denotes in
T2964 15204-15208 FW denotes vivo
T2965 15209-15210 -LRB- denotes (
T2966 15210-15215 NN denotes Table
T2967 15216-15217 CD denotes 2
T2968 15217-15218 -RRB- denotes )
T2969 15218-15219 . denotes .
T3312 15221-15230 JJ denotes Molecular
T3313 15231-15241 NNS denotes Mechanisms
T3314 15242-15244 IN denotes of
T3315 15245-15254 JJ denotes Biallelic
T3316 15255-15262 NNS denotes Effects
T3317 15262-15561 sentence denotes We next turned to UV-based cellular assays including unscheduled DNA synthesis after UV irradiation (UV-UDS), recovery of RNA synthesis after UV irradiation (UV-RRS), and UV survival, which report on the NER subpathways (global genome NER and transcription-coupled NER) and total NER, respectively.
T3318 15263-15265 PRP denotes We
T3320 15266-15270 RB denotes next
T3319 15271-15277 VBD denotes turned
T3321 15278-15280 IN denotes to
T3322 15281-15283 NN denotes UV
T3324 15283-15284 HYPH denotes -
T3323 15284-15289 VBN denotes based
T3326 15290-15298 JJ denotes cellular
T3325 15299-15305 NNS denotes assays
T3327 15306-15315 VBG denotes including
T3328 15316-15327 JJ denotes unscheduled
T3330 15328-15331 NN denotes DNA
T3329 15332-15341 NN denotes synthesis
T3331 15342-15347 IN denotes after
T3332 15348-15350 NN denotes UV
T3333 15351-15362 NN denotes irradiation
T3334 15363-15364 -LRB- denotes (
T3336 15364-15366 NN denotes UV
T3337 15366-15367 HYPH denotes -
T3335 15367-15370 NN denotes UDS
T3338 15370-15371 -RRB- denotes )
T3339 15371-15373 , denotes ,
T3340 15373-15381 NN denotes recovery
T3341 15382-15384 IN denotes of
T3342 15385-15388 NN denotes RNA
T3343 15389-15398 NN denotes synthesis
T3344 15399-15404 IN denotes after
T3345 15405-15407 NN denotes UV
T3346 15408-15419 NN denotes irradiation
T3347 15420-15421 -LRB- denotes (
T3349 15421-15423 NN denotes UV
T3350 15423-15424 HYPH denotes -
T3348 15424-15427 NN denotes RRS
T3351 15427-15428 -RRB- denotes )
T3352 15428-15430 , denotes ,
T3353 15430-15433 CC denotes and
T3354 15434-15436 NN denotes UV
T3355 15437-15445 NN denotes survival
T3356 15445-15447 , denotes ,
T3357 15447-15452 WDT denotes which
T3358 15453-15459 VBP denotes report
T3359 15460-15462 IN denotes on
T3360 15463-15466 DT denotes the
T3362 15467-15470 NN denotes NER
T3361 15471-15482 NNS denotes subpathways
T3363 15483-15484 -LRB- denotes (
T3365 15484-15490 JJ denotes global
T3366 15491-15497 NN denotes genome
T3364 15498-15501 NN denotes NER
T3367 15502-15505 CC denotes and
T3368 15506-15519 NN denotes transcription
T3370 15519-15520 HYPH denotes -
T3369 15520-15527 VBN denotes coupled
T3371 15528-15531 NN denotes NER
T3372 15531-15532 -RRB- denotes )
T3373 15533-15536 CC denotes and
T3374 15537-15542 JJ denotes total
T3375 15543-15546 NN denotes NER
T3376 15546-15548 , denotes ,
T3377 15548-15560 RB denotes respectively
T3378 15560-15561 . denotes .
T3379 15561-15687 sentence denotes In none of these assays was the response to UV improved in compound heterozygotes relative to TTD homozygotes (Figure 4A–4C).
T3380 15562-15564 IN denotes In
T3382 15565-15569 NN denotes none
T3383 15570-15572 IN denotes of
T3384 15573-15578 DT denotes these
T3385 15579-15585 NNS denotes assays
T3386 15586-15589 VBD denotes was
T3387 15590-15593 DT denotes the
T3388 15594-15602 NN denotes response
T3389 15603-15605 IN denotes to
T3390 15606-15608 NN denotes UV
T3381 15609-15617 VBN denotes improved
T3391 15618-15620 IN denotes in
T3392 15621-15629 NN denotes compound
T3393 15630-15643 NNS denotes heterozygotes
T3394 15644-15652 JJ denotes relative
T3395 15653-15655 IN denotes to
T3396 15656-15659 NN denotes TTD
T3397 15660-15671 NNS denotes homozygotes
T3398 15672-15673 -LRB- denotes (
T3400 15673-15679 NN denotes Figure
T3399 15680-15682 NN denotes 4A
T3401 15682-15683 SYM denotes –
T3402 15683-15685 NN denotes 4C
T3403 15685-15686 -RRB- denotes )
T3404 15686-15687 . denotes .
T3405 15687-16033 sentence denotes However, unlike the in vivo TTD phenotypes described above, in which XpdTTD/TTD and XpdTTD/KO animals were indistinguishable, XpdTTD dosage effects were observed in UV survival, UV-UDS, and UV-RRS, indicating that cellular parameters as measured in fibroblasts here do not always correlate with the phenotype at the level of the intact organism.
T3406 15688-15695 RB denotes However
T3408 15695-15697 , denotes ,
T3409 15697-15703 IN denotes unlike
T3410 15704-15707 DT denotes the
T3412 15708-15710 FW denotes in
T3413 15711-15715 FW denotes vivo
T3414 15716-15719 NN denotes TTD
T3411 15720-15730 NNS denotes phenotypes
T3415 15731-15740 VBN denotes described
T3416 15741-15746 RB denotes above
T3417 15746-15748 , denotes ,
T3418 15748-15750 IN denotes in
T3420 15751-15756 WDT denotes which
T3421 15757-15763 NN denotes XpdTTD
T3423 15763-15764 HYPH denotes /
T3422 15764-15767 NN denotes TTD
T3425 15768-15771 CC denotes and
T3426 15772-15778 NN denotes XpdTTD
T3428 15778-15779 HYPH denotes /
T3427 15779-15781 NN denotes KO
T3424 15782-15789 NNS denotes animals
T3419 15790-15794 VBD denotes were
T3429 15795-15812 JJ denotes indistinguishable
T3430 15812-15814 , denotes ,
T3431 15814-15820 NN denotes XpdTTD
T3433 15821-15827 NN denotes dosage
T3432 15828-15835 NNS denotes effects
T3434 15836-15840 VBD denotes were
T3407 15841-15849 VBN denotes observed
T3435 15850-15852 IN denotes in
T3436 15853-15855 NN denotes UV
T3437 15856-15864 NN denotes survival
T3438 15864-15866 , denotes ,
T3439 15866-15868 NN denotes UV
T3441 15868-15869 HYPH denotes -
T3440 15869-15872 NN denotes UDS
T3442 15872-15874 , denotes ,
T3443 15874-15877 CC denotes and
T3444 15878-15880 NN denotes UV
T3446 15880-15881 HYPH denotes -
T3445 15881-15884 NN denotes RRS
T3447 15884-15886 , denotes ,
T3448 15886-15896 VBG denotes indicating
T3449 15897-15901 IN denotes that
T3451 15902-15910 JJ denotes cellular
T3452 15911-15921 NNS denotes parameters
T3453 15922-15924 IN denotes as
T3454 15925-15933 VBN denotes measured
T3455 15934-15936 IN denotes in
T3456 15937-15948 NNS denotes fibroblasts
T3457 15949-15953 RB denotes here
T3458 15954-15956 VBP denotes do
T3459 15957-15960 RB denotes not
T3460 15961-15967 RB denotes always
T3450 15968-15977 VB denotes correlate
T3461 15978-15982 IN denotes with
T3462 15983-15986 DT denotes the
T3463 15987-15996 NN denotes phenotype
T3464 15997-15999 IN denotes at
T3465 16000-16003 DT denotes the
T3466 16004-16009 NN denotes level
T3467 16010-16012 IN denotes of
T3468 16013-16016 DT denotes the
T3470 16017-16023 JJ denotes intact
T3469 16024-16032 NN denotes organism
T3471 16032-16033 . denotes .
T3472 16033-16156 sentence denotes XpdTTD/KO hemizygous cells were thus used as the baseline on which to compare the activity of compound heterozygous cells.
T3473 16034-16040 NN denotes XpdTTD
T3475 16040-16041 HYPH denotes /
T3474 16041-16043 NN denotes KO
T3477 16044-16054 JJ denotes hemizygous
T3476 16055-16060 NNS denotes cells
T3479 16061-16065 VBD denotes were
T3480 16066-16070 RB denotes thus
T3478 16071-16075 VBN denotes used
T3481 16076-16078 IN denotes as
T3482 16079-16082 DT denotes the
T3483 16083-16091 NN denotes baseline
T3484 16092-16094 IN denotes on
T3486 16095-16100 WDT denotes which
T3487 16101-16103 TO denotes to
T3485 16104-16111 VB denotes compare
T3488 16112-16115 DT denotes the
T3489 16116-16124 NN denotes activity
T3490 16125-16127 IN denotes of
T3491 16128-16136 NN denotes compound
T3493 16137-16149 JJ denotes heterozygous
T3492 16150-16155 NNS denotes cells
T3494 16155-16156 . denotes .
T3495 16156-16363 sentence denotes Relative to XpdTTD/KO hemizygote cells, UV survival was improved by the homozygous lethal Xpd†XPCS allele in XpdTTD/†XPCS compound heterozygous cells and to a lesser degree by the Xpd†XP allele (Figure 4A).
T3496 16157-16165 JJ denotes Relative
T3498 16166-16168 IN denotes to
T3499 16169-16175 NN denotes XpdTTD
T3501 16175-16176 HYPH denotes /
T3500 16176-16178 NN denotes KO
T3503 16179-16189 NN denotes hemizygote
T3502 16190-16195 NNS denotes cells
T3504 16195-16197 , denotes ,
T3505 16197-16199 NN denotes UV
T3506 16200-16208 NN denotes survival
T3507 16209-16212 VBD denotes was
T3497 16213-16221 VBN denotes improved
T3508 16222-16224 IN denotes by
T3509 16225-16228 DT denotes the
T3511 16229-16239 JJ denotes homozygous
T3512 16240-16246 JJ denotes lethal
T3513 16247-16255 NN denotes Xpd†XPCS
T3510 16256-16262 NN denotes allele
T3514 16263-16265 IN denotes in
T3515 16266-16272 NN denotes XpdTTD
T3517 16272-16273 HYPH denotes /
T3516 16273-16278 NN denotes †XPCS
T3519 16279-16287 NN denotes compound
T3520 16288-16300 JJ denotes heterozygous
T3518 16301-16306 NNS denotes cells
T3521 16307-16310 CC denotes and
T3522 16311-16313 IN denotes to
T3524 16314-16315 DT denotes a
T3526 16316-16322 JJR denotes lesser
T3525 16323-16329 NN denotes degree
T3523 16330-16332 IN denotes by
T3527 16333-16336 DT denotes the
T3529 16337-16343 NN denotes Xpd†XP
T3528 16344-16350 NN denotes allele
T3530 16351-16352 -LRB- denotes (
T3532 16352-16358 NN denotes Figure
T3531 16359-16361 NN denotes 4A
T3533 16361-16362 -RRB- denotes )
T3534 16362-16363 . denotes .
T3535 16363-16503 sentence denotes Because of embryonic and cellular lethality, we were unable to test UV survival associated exclusively with the Xpd†XPCS or Xpd†XP alleles.
T3536 16364-16371 IN denotes Because
T3538 16372-16374 IN denotes of
T3539 16375-16384 JJ denotes embryonic
T3541 16385-16388 CC denotes and
T3542 16389-16397 JJ denotes cellular
T3540 16398-16407 NN denotes lethality
T3543 16407-16409 , denotes ,
T3544 16409-16411 PRP denotes we
T3537 16412-16416 VBD denotes were
T3545 16417-16423 JJ denotes unable
T3546 16424-16426 TO denotes to
T3547 16427-16431 VB denotes test
T3548 16432-16434 NN denotes UV
T3549 16435-16443 NN denotes survival
T3550 16444-16454 VBN denotes associated
T3551 16455-16466 RB denotes exclusively
T3552 16467-16471 IN denotes with
T3553 16472-16475 DT denotes the
T3555 16476-16484 NN denotes Xpd†XPCS
T3556 16485-16487 CC denotes or
T3557 16488-16494 NN denotes Xpd†XP
T3554 16495-16502 NNS denotes alleles
T3558 16502-16503 . denotes .
T3559 16503-16745 sentence denotes However, homozygous XPDXP (XPDR683W) and hemizygous XPDXPCS (XPDG602D) human cells are known to be highly sensitive to UV [19,25], as are cells from a homozygous viable XpdXPCS/XPCS (XPDG602D/G602D) mouse model (Figure 4A, dotted line) [23].
T3560 16504-16511 RB denotes However
T3562 16511-16513 , denotes ,
T3563 16513-16523 JJ denotes homozygous
T3564 16524-16529 NN denotes XPDXP
T3566 16530-16531 -LRB- denotes (
T3567 16531-16539 NN denotes XPDR683W
T3568 16539-16540 -RRB- denotes )
T3569 16541-16544 CC denotes and
T3570 16545-16555 JJ denotes hemizygous
T3571 16556-16563 NN denotes XPDXPCS
T3572 16564-16565 -LRB- denotes (
T3573 16565-16573 NN denotes XPDG602D
T3574 16573-16574 -RRB- denotes )
T3575 16575-16580 JJ denotes human
T3565 16581-16586 NNS denotes cells
T3576 16587-16590 VBP denotes are
T3561 16591-16596 VBN denotes known
T3577 16597-16599 TO denotes to
T3578 16600-16602 VB denotes be
T3579 16603-16609 RB denotes highly
T3580 16610-16619 JJ denotes sensitive
T3581 16620-16622 IN denotes to
T3582 16623-16625 NN denotes UV
T3583 16626-16627 -LRB- denotes [
T3585 16627-16629 CD denotes 19
T3586 16629-16630 , denotes ,
T3584 16630-16632 CD denotes 25
T3587 16632-16633 -RRB- denotes ]
T3588 16633-16635 , denotes ,
T3589 16635-16637 IN denotes as
T3590 16638-16641 VBP denotes are
T3591 16642-16647 NNS denotes cells
T3592 16648-16652 IN denotes from
T3593 16653-16654 DT denotes a
T3595 16655-16665 JJ denotes homozygous
T3596 16666-16672 JJ denotes viable
T3597 16673-16680 NN denotes XpdXPCS
T3599 16680-16681 HYPH denotes /
T3598 16681-16685 NN denotes XPCS
T3600 16686-16687 -LRB- denotes (
T3602 16687-16695 NN denotes XPDG602D
T3603 16695-16696 HYPH denotes /
T3601 16696-16701 NN denotes G602D
T3604 16701-16702 -RRB- denotes )
T3605 16703-16708 NN denotes mouse
T3594 16709-16714 NN denotes model
T3606 16715-16716 -LRB- denotes (
T3608 16716-16722 NN denotes Figure
T3607 16723-16725 NN denotes 4A
T3609 16725-16727 , denotes ,
T3610 16727-16733 VBN denotes dotted
T3611 16734-16738 NN denotes line
T3612 16738-16739 -RRB- denotes )
T3613 16740-16741 -LRB- denotes [
T3614 16741-16743 CD denotes 23
T3615 16743-16744 -RRB- denotes ]
T3616 16744-16745 . denotes .
T3617 16745-16906 sentence denotes Thus, the survival of XpdTTD/†XPCS (and XpdTTD/†XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2).
T3618 16746-16750 RB denotes Thus
T3620 16750-16752 , denotes ,
T3621 16752-16755 DT denotes the
T3622 16756-16764 NN denotes survival
T3623 16765-16767 IN denotes of
T3624 16768-16774 NN denotes XpdTTD
T3626 16774-16775 HYPH denotes /
T3625 16775-16780 NN denotes †XPCS
T3628 16781-16782 -LRB- denotes (
T3629 16782-16785 CC denotes and
T3630 16786-16792 NN denotes XpdTTD
T3632 16792-16793 HYPH denotes /
T3631 16793-16796 NN denotes †XP
T3633 16796-16797 -RRB- denotes )
T3627 16798-16803 NNS denotes cells
T3634 16804-16810 RB denotes likely
T3619 16811-16821 VBZ denotes represents
T3635 16822-16823 DT denotes a
T3636 16824-16829 NN denotes level
T3637 16830-16832 IN denotes of
T3638 16833-16835 NN denotes UV
T3639 16836-16846 NN denotes resistance
T3640 16847-16851 WDT denotes that
T3642 16852-16859 CC denotes neither
T3644 16860-16866 JJ denotes mutant
T3643 16867-16873 NN denotes allele
T3645 16874-16877 MD denotes can
T3641 16878-16884 VB denotes impart
T3646 16885-16887 IN denotes on
T3647 16888-16891 PRP$ denotes its
T3648 16892-16895 NN denotes own
T3649 16896-16897 -LRB- denotes (
T3650 16897-16902 NN denotes Table
T3651 16903-16904 CD denotes 2
T3652 16904-16905 -RRB- denotes )
T3653 16905-16906 . denotes .
T3654 16906-17064 sentence denotes Significant effects of compound heterozygosity on NER subpathways relative to XpdTTD/KO cells were observed in XpdTTD/†XP cells but only for UV-UDS activity.
T3655 16907-16918 JJ denotes Significant
T3656 16919-16926 NNS denotes effects
T3658 16927-16929 IN denotes of
T3659 16930-16938 NN denotes compound
T3660 16939-16953 NN denotes heterozygosity
T3661 16954-16956 IN denotes on
T3662 16957-16960 NN denotes NER
T3663 16961-16972 NNS denotes subpathways
T3664 16973-16981 JJ denotes relative
T3665 16982-16984 IN denotes to
T3666 16985-16991 NN denotes XpdTTD
T3668 16991-16992 HYPH denotes /
T3667 16992-16994 NN denotes KO
T3669 16995-17000 NNS denotes cells
T3670 17001-17005 VBD denotes were
T3657 17006-17014 VBN denotes observed
T3671 17015-17017 IN denotes in
T3672 17018-17024 NN denotes XpdTTD
T3674 17024-17025 HYPH denotes /
T3673 17025-17028 NN denotes †XP
T3675 17029-17034 NNS denotes cells
T3676 17035-17038 CC denotes but
T3677 17039-17043 RB denotes only
T3678 17044-17047 IN denotes for
T3679 17048-17050 NN denotes UV
T3681 17050-17051 HYPH denotes -
T3680 17051-17054 NN denotes UDS
T3682 17055-17063 NN denotes activity
T3683 17063-17064 . denotes .
T3684 17064-17313 sentence denotes Finally, none of the mutant TFIIH combinations (carrying alterations associated with TTD [XPDR722W], XPCS [XPDG602D], or XP [XPDR683W]) exhibited synergism in an in vitro NER reaction reconstituted with different mutant TFIIH complexes (Figure 4D).
T3685 17065-17072 RB denotes Finally
T3687 17072-17074 , denotes ,
T3688 17074-17078 NN denotes none
T3689 17079-17081 IN denotes of
T3690 17082-17085 DT denotes the
T3692 17086-17092 JJ denotes mutant
T3693 17093-17098 NN denotes TFIIH
T3691 17099-17111 NNS denotes combinations
T3694 17112-17113 -LRB- denotes (
T3695 17113-17121 VBG denotes carrying
T3696 17122-17133 NNS denotes alterations
T3697 17134-17144 VBN denotes associated
T3698 17145-17149 IN denotes with
T3699 17150-17153 NN denotes TTD
T3700 17154-17155 -LRB- denotes [
T3701 17155-17163 NN denotes XPDR722W
T3702 17163-17164 -RRB- denotes ]
T3703 17164-17166 , denotes ,
T3704 17166-17170 NN denotes XPCS
T3705 17171-17172 -LRB- denotes [
T3706 17172-17180 NN denotes XPDG602D
T3707 17180-17181 -RRB- denotes ]
T3708 17181-17183 , denotes ,
T3709 17183-17185 CC denotes or
T3710 17186-17188 NN denotes XP
T3711 17189-17190 -LRB- denotes [
T3712 17190-17198 NN denotes XPDR683W
T3713 17198-17199 -RRB- denotes ]
T3714 17199-17200 -RRB- denotes )
T3686 17201-17210 VBD denotes exhibited
T3715 17211-17220 NN denotes synergism
T3716 17221-17223 IN denotes in
T3717 17224-17226 DT denotes an
T3719 17227-17229 FW denotes in
T3720 17230-17235 FW denotes vitro
T3721 17236-17239 NN denotes NER
T3718 17240-17248 NN denotes reaction
T3722 17249-17262 VBN denotes reconstituted
T3723 17263-17267 IN denotes with
T3724 17268-17277 JJ denotes different
T3726 17278-17284 JJ denotes mutant
T3727 17285-17290 NN denotes TFIIH
T3725 17291-17300 NNS denotes complexes
T3728 17301-17302 -LRB- denotes (
T3730 17302-17308 NN denotes Figure
T3729 17309-17311 NN denotes 4D
T3731 17311-17312 -RRB- denotes )
T3732 17312-17313 . denotes .
T3733 17313-17548 sentence denotes Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV-related repair characteristics and TTD progeroid phenotypes in animal models.
T3734 17314-17319 VBN denotes Taken
T3736 17320-17328 RB denotes together
T3737 17328-17330 , denotes ,
T3738 17330-17335 DT denotes these
T3739 17336-17340 NNS denotes data
T3735 17341-17344 VBP denotes are
T3740 17345-17355 JJ denotes consistent
T3741 17356-17360 IN denotes with
T3742 17361-17373 JJ denotes interallelic
T3743 17374-17389 NN denotes complementation
T3744 17390-17392 IN denotes of
T3745 17393-17395 NN denotes UV
T3746 17396-17407 NN denotes sensitivity
T3747 17408-17410 IN denotes in
T3748 17411-17416 NNS denotes cells
T3749 17417-17420 CC denotes but
T3750 17421-17431 VBP denotes underscore
T3751 17432-17435 DT denotes the
T3752 17436-17440 NN denotes lack
T3753 17441-17443 IN denotes of
T3754 17444-17447 DT denotes any
T3755 17448-17459 NN denotes correlation
T3756 17460-17467 IN denotes between
T3757 17468-17470 NN denotes UV
T3759 17470-17471 HYPH denotes -
T3758 17471-17478 VBN denotes related
T3761 17479-17485 NN denotes repair
T3760 17486-17501 NNS denotes characteristics
T3762 17502-17505 CC denotes and
T3763 17506-17509 NN denotes TTD
T3765 17510-17519 NN denotes progeroid
T3764 17520-17530 NNS denotes phenotypes
T3766 17531-17533 IN denotes in
T3767 17534-17540 NN denotes animal
T3768 17541-17547 NNS denotes models
T3769 17547-17548 . denotes .
T3770 17548-17549 sentence denotes
T8564 17559-17564 NN denotes TFIIH
T8565 17565-17574 NNS denotes Functions
T8566 17575-17578 CC denotes and
T8567 17579-17589 NNS denotes Mechanisms
T8568 17590-17592 IN denotes of
T8569 17593-17596 NN denotes XPD
T8571 17596-17597 HYPH denotes -
T8570 17597-17607 VBN denotes Associated
T8573 17608-17615 NN denotes Disease
T8572 17616-17626 NN denotes Pleiotropy
T8574 17626-17670 sentence denotes (A) Cellular survival after UV irradiation.
T8575 17627-17628 -LRB- denotes (
T8576 17628-17629 LS denotes A
T8578 17629-17630 -RRB- denotes )
T8579 17631-17639 JJ denotes Cellular
T8577 17640-17648 NN denotes survival
T8580 17649-17654 IN denotes after
T8581 17655-17657 NN denotes UV
T8582 17658-17669 NN denotes irradiation
T8583 17669-17670 . denotes .
T8584 17670-17796 sentence denotes Rescue of hemizygous XpdTTD/KO survival by Xpd†XPCS and Xpd†XP alleles is illustrated by arrows marked A and B, respectively.
T8585 17671-17677 NN denotes Rescue
T8587 17678-17680 IN denotes of
T8588 17681-17691 JJ denotes hemizygous
T8590 17692-17698 NN denotes XpdTTD
T8592 17698-17699 HYPH denotes /
T8591 17699-17701 NN denotes KO
T8589 17702-17710 NN denotes survival
T8593 17711-17713 IN denotes by
T8594 17714-17722 NN denotes Xpd†XPCS
T8596 17723-17726 CC denotes and
T8597 17727-17733 NN denotes Xpd†XP
T8595 17734-17741 NNS denotes alleles
T8598 17742-17744 VBZ denotes is
T8586 17745-17756 VBN denotes illustrated
T8599 17757-17759 IN denotes by
T8600 17760-17766 NNS denotes arrows
T8601 17767-17773 VBN denotes marked
T8602 17774-17775 NN denotes A
T8603 17776-17779 CC denotes and
T8604 17780-17781 NN denotes B
T8605 17781-17783 , denotes ,
T8606 17783-17795 RB denotes respectively
T8607 17795-17796 . denotes .
T8608 17796-17934 sentence denotes UV survival of homozygous XpdXPCS/XPCS cells (asterisk) from the normally expressed viable allele (XpdXPCS) is depicted by a dotted line.
T8609 17797-17799 NN denotes UV
T8610 17800-17808 NN denotes survival
T8612 17809-17811 IN denotes of
T8613 17812-17822 JJ denotes homozygous
T8615 17823-17830 NN denotes XpdXPCS
T8617 17830-17831 HYPH denotes /
T8616 17831-17835 NN denotes XPCS
T8614 17836-17841 NNS denotes cells
T8618 17842-17843 -LRB- denotes (
T8619 17843-17851 NN denotes asterisk
T8620 17851-17852 -RRB- denotes )
T8621 17853-17857 IN denotes from
T8622 17858-17861 DT denotes the
T8624 17862-17870 RB denotes normally
T8625 17871-17880 VBN denotes expressed
T8626 17881-17887 JJ denotes viable
T8623 17888-17894 NN denotes allele
T8627 17895-17896 -LRB- denotes (
T8628 17896-17903 NN denotes XpdXPCS
T8629 17903-17904 -RRB- denotes )
T8630 17905-17907 VBZ denotes is
T8611 17908-17916 VBN denotes depicted
T8631 17917-17919 IN denotes by
T8632 17920-17921 DT denotes a
T8634 17922-17928 VBN denotes dotted
T8633 17929-17933 NN denotes line
T8635 17933-17934 . denotes .
T8636 17934-18066 sentence denotes Survival curves represent an average of four independent experiments; 1–2 cell lines per genotype were included in each experiment.
T8637 17935-17943 NN denotes Survival
T8638 17944-17950 NNS denotes curves
T8639 17951-17960 VBP denotes represent
T8641 17961-17963 DT denotes an
T8642 17964-17971 NN denotes average
T8643 17972-17974 IN denotes of
T8644 17975-17979 CD denotes four
T8646 17980-17991 JJ denotes independent
T8645 17992-18003 NNS denotes experiments
T8647 18003-18004 : denotes ;
T8648 18005-18006 CD denotes 1
T8650 18006-18007 SYM denotes –
T8649 18007-18008 CD denotes 2
T8652 18009-18013 NN denotes cell
T8651 18014-18019 NNS denotes lines
T8653 18020-18023 IN denotes per
T8654 18024-18032 NN denotes genotype
T8655 18033-18037 VBD denotes were
T8640 18038-18046 VBN denotes included
T8656 18047-18049 IN denotes in
T8657 18050-18054 DT denotes each
T8658 18055-18065 NN denotes experiment
T8659 18065-18066 . denotes .
T8660 18066-18111 sentence denotes Error bars indicate SEM between experiments.
T8661 18067-18072 NN denotes Error
T8662 18073-18077 NNS denotes bars
T8663 18078-18086 VBP denotes indicate
T8664 18087-18090 NN denotes SEM
T8665 18091-18098 IN denotes between
T8666 18099-18110 NNS denotes experiments
T8667 18110-18111 . denotes .
T8668 18111-18158 sentence denotes (B) UV-UDS, a measure of global genome repair.
T8669 18112-18113 -LRB- denotes (
T8670 18113-18114 LS denotes B
T8672 18114-18115 -RRB- denotes )
T8673 18116-18118 NN denotes UV
T8674 18118-18119 HYPH denotes -
T8671 18119-18122 NN denotes UDS
T8675 18122-18124 , denotes ,
T8676 18124-18125 DT denotes a
T8677 18126-18133 NN denotes measure
T8678 18134-18136 IN denotes of
T8679 18137-18143 JJ denotes global
T8681 18144-18150 NN denotes genome
T8680 18151-18157 NN denotes repair
T8682 18157-18158 . denotes .
T8683 18158-18327 sentence denotes Number of experiments: n = 15 (XpdTTD/TTD), n = 6 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8684 18159-18165 NN denotes Number
T8686 18166-18168 IN denotes of
T8687 18169-18180 NNS denotes experiments
T8688 18180-18182 : denotes :
T8689 18182-18183 NN denotes n
T8691 18184-18185 SYM denotes =
T8690 18186-18188 CD denotes 15
T8692 18189-18190 -LRB- denotes (
T8693 18190-18196 NN denotes XpdTTD
T8694 18196-18197 SYM denotes /
T8695 18197-18200 NN denotes TTD
T8696 18200-18201 -RRB- denotes )
T8697 18201-18203 , denotes ,
T8698 18203-18204 NN denotes n
T8700 18205-18206 SYM denotes =
T8699 18207-18208 CD denotes 6
T8701 18209-18210 -LRB- denotes (
T8703 18210-18216 NN denotes XpdTTD
T8704 18216-18217 HYPH denotes /
T8702 18217-18219 NN denotes KO
T8705 18219-18220 -RRB- denotes )
T8706 18220-18222 , denotes ,
T8707 18222-18223 NN denotes n
T8709 18224-18225 SYM denotes =
T8708 18226-18227 CD denotes 4
T8710 18228-18229 -LRB- denotes (
T8712 18229-18235 NN denotes XpdTTD
T8713 18235-18236 HYPH denotes /
T8711 18236-18241 NN denotes †XPCS
T8714 18242-18243 -RRB- denotes )
T8715 18243-18245 , denotes ,
T8716 18245-18246 NN denotes n
T8718 18247-18248 SYM denotes =
T8717 18249-18250 CD denotes 2
T8719 18251-18252 -LRB- denotes (
T8721 18252-18258 NN denotes XpdTTD
T8722 18258-18259 HYPH denotes /
T8720 18259-18262 NN denotes †XP
T8723 18263-18264 -RRB- denotes )
T8724 18264-18265 : denotes ;
T8725 18266-18267 CD denotes 1
T8727 18267-18268 SYM denotes –
T8726 18268-18269 CD denotes 2
T8729 18270-18274 NN denotes cell
T8728 18275-18280 NNS denotes lines
T8730 18281-18284 IN denotes per
T8731 18285-18293 NN denotes genotype
T8732 18294-18298 VBD denotes were
T8685 18299-18307 VBN denotes included
T8733 18308-18310 IN denotes in
T8734 18311-18315 DT denotes each
T8735 18316-18326 NN denotes experiment
T8736 18326-18327 . denotes .
T8737 18327-18447 sentence denotes The asterisk indicates significant difference with XpdTTD/TTD; crosses indicate significant differences with XpdTTD/KO.
T8738 18328-18331 DT denotes The
T8739 18332-18340 NN denotes asterisk
T8740 18341-18350 VBZ denotes indicates
T8742 18351-18362 JJ denotes significant
T8743 18363-18373 NN denotes difference
T8744 18374-18378 IN denotes with
T8745 18379-18385 NN denotes XpdTTD
T8747 18385-18386 HYPH denotes /
T8746 18386-18389 NN denotes TTD
T8748 18389-18390 : denotes ;
T8749 18391-18398 NNS denotes crosses
T8741 18399-18407 VBP denotes indicate
T8750 18408-18419 JJ denotes significant
T8751 18420-18431 NNS denotes differences
T8752 18432-18436 IN denotes with
T8753 18437-18443 NN denotes XpdTTD
T8755 18443-18444 HYPH denotes /
T8754 18444-18446 NN denotes KO
T8756 18446-18447 . denotes .
T8757 18447-18524 sentence denotes (C) UV-RRS, a measure of transcription-coupled repair of UV-induced lesions.
T8758 18448-18449 -LRB- denotes (
T8759 18449-18450 LS denotes C
T8761 18450-18451 -RRB- denotes )
T8762 18452-18454 NN denotes UV
T8763 18454-18455 HYPH denotes -
T8760 18455-18458 NN denotes RRS
T8764 18458-18460 , denotes ,
T8765 18460-18461 DT denotes a
T8766 18462-18469 NN denotes measure
T8767 18470-18472 IN denotes of
T8768 18473-18486 NN denotes transcription
T8770 18486-18487 HYPH denotes -
T8769 18487-18494 VBN denotes coupled
T8771 18495-18501 NN denotes repair
T8772 18502-18504 IN denotes of
T8773 18505-18507 NN denotes UV
T8775 18507-18508 HYPH denotes -
T8774 18508-18515 VBN denotes induced
T8776 18516-18523 NNS denotes lesions
T8777 18523-18524 . denotes .
T8778 18524-18692 sentence denotes Number of experiments: n = 7 (XpdTTD/TTD), n = 2 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8779 18525-18531 NN denotes Number
T8781 18532-18534 IN denotes of
T8782 18535-18546 NNS denotes experiments
T8783 18546-18548 : denotes :
T8784 18548-18549 NN denotes n
T8786 18550-18551 SYM denotes =
T8785 18552-18553 CD denotes 7
T8787 18554-18555 -LRB- denotes (
T8789 18555-18561 NN denotes XpdTTD
T8790 18561-18562 HYPH denotes /
T8788 18562-18565 NN denotes TTD
T8791 18565-18566 -RRB- denotes )
T8792 18566-18568 , denotes ,
T8793 18568-18569 NN denotes n
T8795 18570-18571 SYM denotes =
T8794 18572-18573 CD denotes 2
T8796 18574-18575 -LRB- denotes (
T8798 18575-18581 NN denotes XpdTTD
T8799 18581-18582 HYPH denotes /
T8797 18582-18584 NN denotes KO
T8800 18584-18585 -RRB- denotes )
T8801 18585-18587 , denotes ,
T8802 18587-18588 NN denotes n
T8804 18589-18590 SYM denotes =
T8803 18591-18592 CD denotes 4
T8805 18593-18594 -LRB- denotes (
T8807 18594-18600 NN denotes XpdTTD
T8808 18600-18601 HYPH denotes /
T8806 18601-18606 NN denotes †XPCS
T8809 18607-18608 -RRB- denotes )
T8810 18608-18610 , denotes ,
T8811 18610-18611 NN denotes n
T8813 18612-18613 SYM denotes =
T8812 18614-18615 CD denotes 2
T8814 18616-18617 -LRB- denotes (
T8816 18617-18623 NN denotes XpdTTD
T8817 18623-18624 HYPH denotes /
T8815 18624-18627 NN denotes †XP
T8818 18628-18629 -RRB- denotes )
T8819 18629-18630 : denotes ;
T8820 18631-18632 CD denotes 1
T8822 18632-18633 SYM denotes –
T8821 18633-18634 CD denotes 2
T8824 18635-18639 NN denotes cell
T8823 18640-18645 NNS denotes lines
T8825 18646-18649 IN denotes per
T8826 18650-18658 NN denotes genotype
T8827 18659-18663 VBD denotes were
T8780 18664-18672 VBN denotes included
T8828 18673-18675 IN denotes in
T8829 18676-18680 DT denotes each
T8830 18681-18691 NN denotes experiment
T8831 18691-18692 . denotes .
T8832 18692-18799 sentence denotes (D) Incision/excision activity of combinations of altered TFIIH complexes in a reconstituted NER reaction.
T8833 18693-18694 -LRB- denotes (
T8834 18694-18695 LS denotes D
T8836 18695-18696 -RRB- denotes )
T8837 18697-18705 NN denotes Incision
T8839 18705-18706 HYPH denotes /
T8838 18706-18714 NN denotes excision
T8835 18715-18723 NN denotes activity
T8840 18724-18726 IN denotes of
T8841 18727-18739 NNS denotes combinations
T8842 18740-18742 IN denotes of
T8843 18743-18750 VBN denotes altered
T8845 18751-18756 NN denotes TFIIH
T8844 18757-18766 NNS denotes complexes
T8846 18767-18769 IN denotes in
T8847 18770-18771 DT denotes a
T8849 18772-18785 VBN denotes reconstituted
T8850 18786-18789 NN denotes NER
T8848 18790-18798 NN denotes reaction
T8851 18798-18799 . denotes .
T8852 18799-19053 sentence denotes Equal amounts of single or mixed populations of recombinant TFIIHs (containing XPD, XPB, p62, p52, His-p44, Flag-p34, cdk7, cyclin H, Mat1, and p8) were mixed with recombinant XPG, XPF/ERCC1, XPC/hHR23B, RPA, and a radiolabelled synthetic NER substrate.
T8853 18800-18805 JJ denotes Equal
T8854 18806-18813 NNS denotes amounts
T8856 18814-18816 IN denotes of
T8857 18817-18823 JJ denotes single
T8859 18824-18826 CC denotes or
T8860 18827-18832 JJ denotes mixed
T8858 18833-18844 NNS denotes populations
T8861 18845-18847 IN denotes of
T8862 18848-18859 JJ denotes recombinant
T8863 18860-18866 NNS denotes TFIIHs
T8864 18867-18868 -LRB- denotes (
T8865 18868-18878 VBG denotes containing
T8866 18879-18882 NN denotes XPD
T8867 18882-18884 , denotes ,
T8868 18884-18887 NN denotes XPB
T8869 18887-18889 , denotes ,
T8870 18889-18892 NN denotes p62
T8871 18892-18894 , denotes ,
T8872 18894-18897 NN denotes p52
T8873 18897-18899 , denotes ,
T8874 18899-18902 NN denotes His
T8876 18902-18903 HYPH denotes -
T8875 18903-18906 NN denotes p44
T8877 18906-18908 , denotes ,
T8878 18908-18912 NN denotes Flag
T8880 18912-18913 HYPH denotes -
T8879 18913-18916 NN denotes p34
T8881 18916-18918 , denotes ,
T8882 18918-18922 NN denotes cdk7
T8883 18922-18924 , denotes ,
T8884 18924-18930 NN denotes cyclin
T8885 18931-18932 NN denotes H
T8886 18932-18934 , denotes ,
T8887 18934-18938 NN denotes Mat1
T8888 18938-18940 , denotes ,
T8889 18940-18943 CC denotes and
T8890 18944-18946 NN denotes p8
T8891 18946-18947 -RRB- denotes )
T8892 18948-18952 VBD denotes were
T8855 18953-18958 VBN denotes mixed
T8893 18959-18963 IN denotes with
T8894 18964-18975 JJ denotes recombinant
T8895 18976-18979 NN denotes XPG
T8896 18979-18981 , denotes ,
T8897 18981-18984 NN denotes XPF
T8899 18984-18985 HYPH denotes /
T8898 18985-18990 NN denotes ERCC1
T8900 18990-18992 , denotes ,
T8901 18992-18995 NN denotes XPC
T8903 18995-18996 HYPH denotes /
T8902 18996-19002 NN denotes hHR23B
T8904 19002-19004 , denotes ,
T8905 19004-19007 NN denotes RPA
T8906 19007-19009 , denotes ,
T8907 19009-19012 CC denotes and
T8908 19013-19014 DT denotes a
T8910 19015-19028 VBN denotes radiolabelled
T8911 19029-19038 JJ denotes synthetic
T8912 19039-19042 NN denotes NER
T8909 19043-19052 NN denotes substrate
T8913 19052-19053 . denotes .
T8914 19053-19196 sentence denotes The excision products (26–34 nucleotides in length) were visualised at nucleotide resolution on a denaturing polyacrylamide gel as indicated .
T8915 19054-19057 DT denotes The
T8917 19058-19066 NN denotes excision
T8916 19067-19075 NNS denotes products
T8919 19076-19077 -LRB- denotes (
T8921 19077-19079 CD denotes 26
T8923 19079-19080 SYM denotes –
T8922 19080-19082 CD denotes 34
T8920 19083-19094 NNS denotes nucleotides
T8924 19095-19097 IN denotes in
T8925 19098-19104 NN denotes length
T8926 19104-19105 -RRB- denotes )
T8927 19106-19110 VBD denotes were
T8918 19111-19121 VBN denotes visualised
T8928 19122-19124 IN denotes at
T8929 19125-19135 NN denotes nucleotide
T8930 19136-19146 NN denotes resolution
T8931 19147-19149 IN denotes on
T8932 19150-19151 DT denotes a
T8934 19152-19162 VBG denotes denaturing
T8935 19163-19177 NN denotes polyacrylamide
T8933 19178-19181 NN denotes gel
T8936 19182-19184 IN denotes as
T8937 19185-19194 VBN denotes indicated
T8938 19195-19196 . denotes .
T8939 19196-19347 sentence denotes Note the weak activity corresponding to each single and combined TFIIH complex (lanes 3–8) relative to the wt (lane 1) and negative controls (lane 2).
T8940 19197-19201 VB denotes Note
T8941 19202-19205 DT denotes the
T8943 19206-19210 JJ denotes weak
T8942 19211-19219 NN denotes activity
T8944 19220-19233 VBG denotes corresponding
T8945 19234-19236 IN denotes to
T8946 19237-19241 DT denotes each
T8948 19242-19248 JJ denotes single
T8949 19249-19252 CC denotes and
T8950 19253-19261 VBN denotes combined
T8951 19262-19267 NN denotes TFIIH
T8947 19268-19275 NN denotes complex
T8952 19276-19277 -LRB- denotes (
T8954 19277-19282 NNS denotes lanes
T8953 19283-19284 CD denotes 3
T8955 19284-19285 SYM denotes –
T8956 19285-19286 CD denotes 8
T8957 19286-19287 -RRB- denotes )
T8958 19288-19296 JJ denotes relative
T8959 19297-19299 IN denotes to
T8960 19300-19303 DT denotes the
T8961 19304-19306 NN denotes wt
T8962 19307-19308 -LRB- denotes (
T8963 19308-19312 NN denotes lane
T8964 19313-19314 CD denotes 1
T8965 19314-19315 -RRB- denotes )
T8966 19316-19319 CC denotes and
T8967 19320-19328 JJ denotes negative
T8968 19329-19337 NNS denotes controls
T8969 19338-19339 -LRB- denotes (
T8970 19339-19343 NN denotes lane
T8971 19344-19345 CD denotes 2
T8972 19345-19346 -RRB- denotes )
T8973 19346-19347 . denotes .
T8974 19347-19560 sentence denotes (E) Xpd dose-dependent reduction of TFIIH in homozygous XpdTTD/TTD, hemizygous XpdTTD/KO, and compound heterozygous XpdTTD/†XPCS and XpdTTD/†XP cells by comparative immunofluorescence of the p62 subunit of TFIIH.
T8975 19348-19349 -LRB- denotes (
T8976 19349-19350 LS denotes E
T8978 19350-19351 -RRB- denotes )
T8979 19352-19355 NN denotes Xpd
T8980 19356-19360 NN denotes dose
T8982 19360-19361 HYPH denotes -
T8981 19361-19370 JJ denotes dependent
T8977 19371-19380 NN denotes reduction
T8983 19381-19383 IN denotes of
T8984 19384-19389 NN denotes TFIIH
T8985 19390-19392 IN denotes in
T8986 19393-19403 JJ denotes homozygous
T8988 19404-19410 NN denotes XpdTTD
T8989 19410-19411 HYPH denotes /
T8987 19411-19414 NN denotes TTD
T8991 19414-19416 , denotes ,
T8992 19416-19426 JJ denotes hemizygous
T8994 19427-19433 NN denotes XpdTTD
T8995 19433-19434 HYPH denotes /
T8993 19434-19436 NN denotes KO
T8996 19436-19438 , denotes ,
T8997 19438-19441 CC denotes and
T8998 19442-19450 NN denotes compound
T9000 19451-19463 JJ denotes heterozygous
T9001 19464-19470 NN denotes XpdTTD
T9002 19470-19471 HYPH denotes /
T8999 19471-19476 NN denotes †XPCS
T9003 19477-19480 CC denotes and
T9004 19481-19487 NN denotes XpdTTD
T9006 19487-19488 HYPH denotes /
T9005 19488-19491 NN denotes †XP
T8990 19492-19497 NNS denotes cells
T9007 19498-19500 IN denotes by
T9008 19501-19512 JJ denotes comparative
T9009 19513-19531 NN denotes immunofluorescence
T9010 19532-19534 IN denotes of
T9011 19535-19538 DT denotes the
T9013 19539-19542 NN denotes p62
T9012 19543-19550 NN denotes subunit
T9014 19551-19553 IN denotes of
T9015 19554-19559 NN denotes TFIIH
T9016 19559-19560 . denotes .
T9017 19560-19978 sentence denotes Roman numerals represent different microscopic slides and Arabic numerals different cell lines labelled as follows: (I) wt cells (1) labelled with 2-μm beads, XpdTTD/TTD cells (2) with 0.79-μm beads, and XpdTTD/KO cells (3) with no beads; (II) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XPCS cells (4) with no beads; and (III) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XP cells (5) with no beads.
T9018 19561-19566 JJ denotes Roman
T9019 19567-19575 NNS denotes numerals
T9020 19576-19585 VBP denotes represent
T9021 19586-19595 JJ denotes different
T9023 19596-19607 JJ denotes microscopic
T9022 19608-19614 NNS denotes slides
T9024 19615-19618 CC denotes and
T9025 19619-19625 JJ denotes Arabic
T9026 19626-19634 NNS denotes numerals
T9028 19635-19644 JJ denotes different
T9029 19645-19649 NN denotes cell
T9027 19650-19655 NNS denotes lines
T9030 19656-19664 VBN denotes labelled
T9031 19665-19667 IN denotes as
T9032 19668-19675 VBZ denotes follows
T9033 19675-19677 : denotes :
T9034 19677-19678 -LRB- denotes (
T9035 19678-19679 LS denotes I
T9037 19679-19680 -RRB- denotes )
T9038 19681-19683 NN denotes wt
T9036 19684-19689 NNS denotes cells
T9039 19690-19691 -LRB- denotes (
T9040 19691-19692 CD denotes 1
T9041 19692-19693 -RRB- denotes )
T9042 19694-19702 VBN denotes labelled
T9043 19703-19707 IN denotes with
T9044 19708-19709 CD denotes 2
T9046 19709-19710 HYPH denotes -
T9045 19710-19712 NN denotes μm
T9047 19713-19718 NNS denotes beads
T9048 19718-19720 , denotes ,
T9049 19720-19726 NN denotes XpdTTD
T9051 19726-19727 HYPH denotes /
T9050 19727-19730 NN denotes TTD
T9052 19731-19736 NNS denotes cells
T9053 19737-19738 -LRB- denotes (
T9054 19738-19739 CD denotes 2
T9055 19739-19740 -RRB- denotes )
T9056 19741-19745 IN denotes with
T9057 19746-19750 CD denotes 0.79
T9059 19750-19751 HYPH denotes -
T9058 19751-19753 NN denotes μm
T9060 19754-19759 NNS denotes beads
T9061 19759-19761 , denotes ,
T9062 19761-19764 CC denotes and
T9063 19765-19771 NN denotes XpdTTD
T9065 19771-19772 HYPH denotes /
T9064 19772-19774 NN denotes KO
T9066 19775-19780 NNS denotes cells
T9067 19781-19782 -LRB- denotes (
T9068 19782-19783 CD denotes 3
T9069 19783-19784 -RRB- denotes )
T9070 19785-19789 IN denotes with
T9071 19790-19792 DT denotes no
T9072 19793-19798 NNS denotes beads
T9073 19798-19799 : denotes ;
T9074 19800-19801 -LRB- denotes (
T9075 19801-19803 LS denotes II
T9077 19803-19804 -RRB- denotes )
T9078 19805-19807 NN denotes wt
T9076 19808-19813 NNS denotes cells
T9079 19814-19815 -LRB- denotes (
T9080 19815-19816 CD denotes 1
T9081 19816-19817 -RRB- denotes )
T9082 19818-19826 VBN denotes labelled
T9083 19827-19831 IN denotes with
T9084 19832-19836 CD denotes 0.79
T9086 19836-19837 HYPH denotes -
T9085 19837-19839 NN denotes μm
T9087 19840-19845 NNS denotes beads
T9088 19846-19849 CC denotes and
T9089 19850-19856 NN denotes XpdTTD
T9091 19856-19857 HYPH denotes /
T9090 19857-19862 NN denotes †XPCS
T9092 19863-19868 NNS denotes cells
T9093 19869-19870 -LRB- denotes (
T9094 19870-19871 CD denotes 4
T9095 19871-19872 -RRB- denotes )
T9096 19873-19877 IN denotes with
T9097 19878-19880 DT denotes no
T9098 19881-19886 NNS denotes beads
T9099 19886-19887 : denotes ;
T9100 19888-19891 CC denotes and
T9101 19892-19893 -LRB- denotes (
T9102 19893-19896 LS denotes III
T9104 19896-19897 -RRB- denotes )
T9105 19898-19900 NN denotes wt
T9103 19901-19906 NNS denotes cells
T9106 19907-19908 -LRB- denotes (
T9107 19908-19909 CD denotes 1
T9108 19909-19910 -RRB- denotes )
T9109 19911-19919 VBN denotes labelled
T9110 19920-19924 IN denotes with
T9111 19925-19929 CD denotes 0.79
T9113 19929-19930 HYPH denotes -
T9112 19930-19932 NN denotes μm
T9114 19933-19938 NNS denotes beads
T9115 19939-19942 CC denotes and
T9116 19943-19949 NN denotes XpdTTD
T9118 19949-19950 HYPH denotes /
T9117 19950-19953 NN denotes †XP
T9119 19954-19959 NNS denotes cells
T9120 19960-19961 -LRB- denotes (
T9121 19961-19962 CD denotes 5
T9122 19962-19963 -RRB- denotes )
T9123 19964-19968 IN denotes with
T9124 19969-19971 DT denotes no
T9125 19972-19977 NNS denotes beads
T9126 19977-19978 . denotes .
T9127 19978-20097 sentence denotes (F) Quantification of immunofluorescent signal from at least 50 nuclei per cell line and 2–6 experiments per genotype.
T9128 19979-19980 -LRB- denotes (
T9129 19980-19981 LS denotes F
T9131 19981-19982 -RRB- denotes )
T9130 19983-19997 NN denotes Quantification
T9132 19998-20000 IN denotes of
T9133 20001-20018 JJ denotes immunofluorescent
T9134 20019-20025 NN denotes signal
T9135 20026-20030 IN denotes from
T9136 20031-20033 RB denotes at
T9138 20034-20039 RBS denotes least
T9137 20040-20042 CD denotes 50
T9139 20043-20049 NNS denotes nuclei
T9140 20050-20053 IN denotes per
T9141 20054-20058 NN denotes cell
T9142 20059-20063 NN denotes line
T9143 20064-20067 CC denotes and
T9144 20068-20069 CD denotes 2
T9146 20069-20070 SYM denotes –
T9145 20070-20071 CD denotes 6
T9147 20072-20083 NNS denotes experiments
T9148 20084-20087 IN denotes per
T9149 20088-20096 NN denotes genotype
T9150 20096-20097 . denotes .
T9151 20097-20208 sentence denotes Bars representing cells analysed on the same microscopic slide are depicted side by side, with wt set at 100%.
T9152 20098-20102 NNS denotes Bars
T9154 20103-20115 VBG denotes representing
T9155 20116-20121 NNS denotes cells
T9156 20122-20130 VBN denotes analysed
T9157 20131-20133 IN denotes on
T9158 20134-20137 DT denotes the
T9160 20138-20142 JJ denotes same
T9161 20143-20154 JJ denotes microscopic
T9159 20155-20160 NN denotes slide
T9162 20161-20164 VBP denotes are
T9153 20165-20173 VBN denotes depicted
T9163 20174-20178 NN denotes side
T9164 20179-20181 IN denotes by
T9165 20182-20186 NN denotes side
T9166 20186-20188 , denotes ,
T9167 20188-20192 IN denotes with
T9168 20193-20195 NN denotes wt
T9169 20196-20199 VBN denotes set
T9170 20200-20202 IN denotes at
T9171 20203-20206 CD denotes 100
T9172 20206-20207 NN denotes %
T9173 20207-20208 . denotes .
T9174 20208-20363 sentence denotes The p-value indicates minimum significant difference between wt and the indicated cell lines analysed on the same microscopic slide within one experiment.
T9175 20209-20212 DT denotes The
T9177 20213-20214 NN denotes p
T9178 20214-20215 HYPH denotes -
T9176 20215-20220 NN denotes value
T9179 20221-20230 VBZ denotes indicates
T9180 20231-20238 JJ denotes minimum
T9182 20239-20250 JJ denotes significant
T9181 20251-20261 NN denotes difference
T9183 20262-20269 IN denotes between
T9184 20270-20272 NN denotes wt
T9185 20273-20276 CC denotes and
T9186 20277-20280 DT denotes the
T9188 20281-20290 VBN denotes indicated
T9189 20291-20295 NN denotes cell
T9187 20296-20301 NNS denotes lines
T9190 20302-20310 VBN denotes analysed
T9191 20311-20313 IN denotes on
T9192 20314-20317 DT denotes the
T9194 20318-20322 JJ denotes same
T9195 20323-20334 JJ denotes microscopic
T9193 20335-20340 NN denotes slide
T9196 20341-20347 IN denotes within
T9197 20348-20351 CD denotes one
T9198 20352-20362 NN denotes experiment
T9199 20362-20363 . denotes .
T3772 20364-20366 NN denotes Ne
T3771 20364-20373 sentence denotes Next we a
T3773 20366-20368 NNS denotes xt
T3774 20368-20369 : denotes
T3775 20369-20371 VBD denotes we
T3776 20372-20373 DT denotes a
T3778 20373-20375 NN denotes sk
T3777 20373-20383 sentence denotes sked wheth
T3779 20375-20376 VBZ denotes e
T3781 20376-20377 NN denotes d
T3782 20378-20380 IN denotes wh
T3783 20380-20381 NNS denotes e
T3780 20381-20382 VBP denotes t
T3784 20382-20383 IN denotes h
T3786 20383-20385 NN denotes er
T3785 20383-20387 sentence denotes er t
T3787 20386-20387 NN denotes t
T3789 20387-20388 DT denotes h
T3788 20387-20389 sentence denotes he
T3790 20388-20389 NN denotes e
T3791 20389-20390 sentence denotes
T3793 20390-20391 NN denotes X
T3792 20390-20393 sentence denotes Xpd
T3794 20391-20392 NN denotes p
T3795 20392-20393 NN denotes d
T3797 20393-20398 NN denotes †XPCS
T3796 20393-20412 sentence denotes †XPCS and Xpd†XP al
T3798 20399-20402 CC denotes and
T3799 20403-20406 NN denotes Xpd
T3800 20406-20409 NN denotes †XP
T3801 20410-20411 JJ denotes a
T3802 20411-20412 NN denotes l
T3804 20412-20413 NNS denotes l
T3803 20412-20430 sentence denotes leles, despite dec
T3805 20413-20414 VBP denotes e
T3806 20414-20417 NNS denotes les
T3807 20417-20419 , denotes ,
T3808 20419-20420 NN denotes d
T3809 20420-20422 NNS denotes es
T3810 20422-20423 NN denotes p
T3811 20423-20425 IN denotes it
T3812 20425-20426 NNS denotes e
T3813 20427-20428 VBN denotes d
T3814 20428-20429 NNS denotes e
T3815 20429-20430 NNS denotes c
T3817 20430-20432 JJ denotes re
T3816 20430-20438 sentence denotes reased m
T3818 20432-20433 NN denotes a
T3819 20433-20434 RBS denotes s
T3820 20434-20435 NNS denotes e
T3821 20435-20436 CC denotes d
T3822 20437-20438 NNS denotes m
T3826 20438-20441 NN denotes RNA
T3823 20438-20571 sentence denotes RNA levels, ameliorated TTD symptoms by increasing overall TFIIH levels in compound heterozygous XpdTTD/ †XPCS and XpdTTD/ †XP cells.
T3825 20442-20448 NNS denotes levels
T3827 20448-20450 , denotes ,
T3824 20450-20461 VBN denotes ameliorated
T3828 20462-20465 NN denotes TTD
T3829 20466-20474 NNS denotes symptoms
T3830 20475-20477 IN denotes by
T3831 20478-20488 VBG denotes increasing
T3833 20489-20496 JJ denotes overall
T3834 20497-20502 NN denotes TFIIH
T3832 20503-20509 NNS denotes levels
T3835 20510-20512 IN denotes in
T3836 20513-20521 NN denotes compound
T3838 20522-20534 JJ denotes heterozygous
T3839 20535-20541 NN denotes XpdTTD
T3841 20541-20542 HYPH denotes /
T3840 20542-20548 NN denotes  †XPCS
T3842 20549-20552 CC denotes and
T3843 20553-20559 NN denotes XpdTTD
T3845 20559-20560 HYPH denotes /
T3844 20560-20564 NN denotes  †XP
T3837 20565-20570 NNS denotes cells
T3846 20570-20571 . denotes .
T3847 20571-20793 sentence denotes Previously, using comparative immunohistochemistry, we and others have shown an up to 70% reduction of TFIIH levels in primary fibroblasts from patients with TTD compared with wt controls due to reduced stability [16,17].
T3848 20572-20582 RB denotes Previously
T3850 20582-20584 , denotes ,
T3851 20584-20589 VBG denotes using
T3852 20590-20601 JJ denotes comparative
T3853 20602-20622 NN denotes immunohistochemistry
T3854 20622-20624 , denotes ,
T3855 20624-20626 PRP denotes we
T3856 20627-20630 CC denotes and
T3857 20631-20637 NNS denotes others
T3858 20638-20642 VBP denotes have
T3849 20643-20648 VBN denotes shown
T3859 20649-20651 DT denotes an
T3861 20652-20654 IN denotes up
T3863 20655-20657 IN denotes to
T3862 20658-20660 CD denotes 70
T3864 20660-20661 NN denotes %
T3860 20662-20671 NN denotes reduction
T3865 20672-20674 IN denotes of
T3866 20675-20680 NN denotes TFIIH
T3867 20681-20687 NNS denotes levels
T3868 20688-20690 IN denotes in
T3869 20691-20698 JJ denotes primary
T3870 20699-20710 NNS denotes fibroblasts
T3871 20711-20715 IN denotes from
T3872 20716-20724 NNS denotes patients
T3873 20725-20729 IN denotes with
T3874 20730-20733 NN denotes TTD
T3875 20734-20742 VBN denotes compared
T3876 20743-20747 IN denotes with
T3877 20748-20750 NN denotes wt
T3878 20751-20759 NNS denotes controls
T3879 20760-20763 IN denotes due
T3880 20764-20766 IN denotes to
T3881 20767-20774 VBN denotes reduced
T3882 20775-20784 NN denotes stability
T3883 20785-20786 -LRB- denotes [
T3885 20786-20788 CD denotes 16
T3886 20788-20789 , denotes ,
T3884 20789-20791 CD denotes 17
T3887 20791-20792 -RRB- denotes ]
T3888 20792-20793 . denotes .
T3889 20793-21047 sentence denotes Despite overexpression of mRNA from the XpdTTD allele relative to the wt allele (Figure 1E), TFIIH protein levels were reduced by 50% in primary mouse XpdTTD/TTD fibroblasts (Figure 4E and 4F), thereby mimicking the situation in human patients with TTD.
T3890 20794-20801 IN denotes Despite
T3892 20802-20816 NN denotes overexpression
T3893 20817-20819 IN denotes of
T3894 20820-20824 NN denotes mRNA
T3895 20825-20829 IN denotes from
T3896 20830-20833 DT denotes the
T3898 20834-20840 NN denotes XpdTTD
T3897 20841-20847 NN denotes allele
T3899 20848-20856 JJ denotes relative
T3900 20857-20859 IN denotes to
T3901 20860-20863 DT denotes the
T3903 20864-20866 NN denotes wt
T3902 20867-20873 NN denotes allele
T3904 20874-20875 -LRB- denotes (
T3906 20875-20881 NN denotes Figure
T3905 20882-20884 NN denotes 1E
T3907 20884-20885 -RRB- denotes )
T3908 20885-20887 , denotes ,
T3909 20887-20892 NN denotes TFIIH
T3911 20893-20900 NN denotes protein
T3910 20901-20907 NNS denotes levels
T3912 20908-20912 VBD denotes were
T3891 20913-20920 VBN denotes reduced
T3913 20921-20923 IN denotes by
T3914 20924-20926 CD denotes 50
T3915 20926-20927 NN denotes %
T3916 20928-20930 IN denotes in
T3917 20931-20938 JJ denotes primary
T3919 20939-20944 NN denotes mouse
T3920 20945-20951 NN denotes XpdTTD
T3922 20951-20952 HYPH denotes /
T3921 20952-20955 NN denotes TTD
T3918 20956-20967 NNS denotes fibroblasts
T3923 20968-20969 -LRB- denotes (
T3925 20969-20975 NN denotes Figure
T3924 20976-20978 NN denotes 4E
T3926 20979-20982 CC denotes and
T3927 20983-20985 NN denotes 4F
T3928 20985-20986 -RRB- denotes )
T3929 20986-20988 , denotes ,
T3930 20988-20995 RB denotes thereby
T3931 20996-21005 VBG denotes mimicking
T3932 21006-21009 DT denotes the
T3933 21010-21019 NN denotes situation
T3934 21020-21022 IN denotes in
T3935 21023-21028 JJ denotes human
T3936 21029-21037 NNS denotes patients
T3937 21038-21042 IN denotes with
T3938 21043-21046 NN denotes TTD
T3939 21046-21047 . denotes .
T3940 21047-21176 sentence denotes In accordance with the gene dosage, a further reduction of up to 70% of the wt level was observed in hemizygous XpdTTD/KO cells.
T3941 21048-21050 IN denotes In
T3943 21051-21061 NN denotes accordance
T3944 21062-21066 IN denotes with
T3945 21067-21070 DT denotes the
T3947 21071-21075 NN denotes gene
T3946 21076-21082 NN denotes dosage
T3948 21082-21084 , denotes ,
T3949 21084-21085 DT denotes a
T3951 21086-21093 JJ denotes further
T3950 21094-21103 NN denotes reduction
T3952 21104-21106 IN denotes of
T3953 21107-21109 IN denotes up
T3955 21110-21112 IN denotes to
T3954 21113-21115 CD denotes 70
T3956 21115-21116 NN denotes %
T3957 21117-21119 IN denotes of
T3958 21120-21123 DT denotes the
T3960 21124-21126 NN denotes wt
T3959 21127-21132 NN denotes level
T3961 21133-21136 VBD denotes was
T3942 21137-21145 VBN denotes observed
T3962 21146-21148 IN denotes in
T3963 21149-21159 JJ denotes hemizygous
T3965 21160-21166 NN denotes XpdTTD
T3967 21166-21167 HYPH denotes /
T3966 21167-21169 NN denotes KO
T3964 21170-21175 NNS denotes cells
T3968 21175-21176 . denotes .
T3969 21176-21370 sentence denotes Consistent with low mRNA expression levels, neither the Xpd†XPCS nor the Xpd†XP allele was able to restore TFIIH abundance to wt levels in XpdTTD compound heterozygote cells (Figure 4E and 4F).
T3970 21177-21187 JJ denotes Consistent
T3972 21188-21192 IN denotes with
T3973 21193-21196 JJ denotes low
T3975 21197-21201 NN denotes mRNA
T3976 21202-21212 NN denotes expression
T3974 21213-21219 NNS denotes levels
T3977 21219-21221 , denotes ,
T3978 21221-21228 CC denotes neither
T3980 21229-21232 DT denotes the
T3981 21233-21241 NN denotes Xpd†XPCS
T3982 21242-21245 CC denotes nor
T3983 21246-21249 DT denotes the
T3984 21250-21256 NN denotes Xpd†XP
T3979 21257-21263 NN denotes allele
T3971 21264-21267 VBD denotes was
T3985 21268-21272 JJ denotes able
T3986 21273-21275 TO denotes to
T3987 21276-21283 VB denotes restore
T3988 21284-21289 NN denotes TFIIH
T3989 21290-21299 NN denotes abundance
T3990 21300-21302 IN denotes to
T3991 21303-21305 NN denotes wt
T3992 21306-21312 NNS denotes levels
T3993 21313-21315 IN denotes in
T3994 21316-21322 NN denotes XpdTTD
T3996 21323-21331 NN denotes compound
T3997 21332-21344 NN denotes heterozygote
T3995 21345-21350 NNS denotes cells
T3998 21351-21352 -LRB- denotes (
T4000 21352-21358 NN denotes Figure
T3999 21359-21361 NN denotes 4E
T4001 21362-21365 CC denotes and
T4002 21366-21368 NN denotes 4F
T4003 21368-21369 -RRB- denotes )
T4004 21369-21370 . denotes .
T4005 21370-21647 sentence denotes Thus, the improved UV survival observed in compound heterozygote cells (Figure 4A) and likely the rescue of TTD progeroid symptoms (Figure 3) were not due to normalisation of TFIIH levels, suggesting a qualitative rather than a quantitative effect on these phenotypes in vivo.
T4006 21371-21375 RB denotes Thus
T4008 21375-21377 , denotes ,
T4009 21377-21380 DT denotes the
T4011 21381-21389 VBN denotes improved
T4012 21390-21392 NN denotes UV
T4010 21393-21401 NN denotes survival
T4013 21402-21410 VBN denotes observed
T4014 21411-21413 IN denotes in
T4015 21414-21422 NN denotes compound
T4017 21423-21435 NN denotes heterozygote
T4016 21436-21441 NNS denotes cells
T4018 21442-21443 -LRB- denotes (
T4020 21443-21449 NN denotes Figure
T4019 21450-21452 NN denotes 4A
T4021 21452-21453 -RRB- denotes )
T4022 21454-21457 CC denotes and
T4023 21458-21464 RB denotes likely
T4025 21465-21468 DT denotes the
T4024 21469-21475 NN denotes rescue
T4026 21476-21478 IN denotes of
T4027 21479-21482 NN denotes TTD
T4029 21483-21492 NN denotes progeroid
T4028 21493-21501 NNS denotes symptoms
T4030 21502-21503 -LRB- denotes (
T4031 21503-21509 NN denotes Figure
T4032 21510-21511 CD denotes 3
T4033 21511-21512 -RRB- denotes )
T4007 21513-21517 VBD denotes were
T4034 21518-21521 RB denotes not
T4035 21522-21525 IN denotes due
T4036 21526-21528 IN denotes to
T4037 21529-21542 NN denotes normalisation
T4038 21543-21545 IN denotes of
T4039 21546-21551 NN denotes TFIIH
T4040 21552-21558 NNS denotes levels
T4041 21558-21560 , denotes ,
T4042 21560-21570 VBG denotes suggesting
T4043 21571-21572 DT denotes a
T4044 21573-21584 JJ denotes qualitative
T4046 21585-21591 RB denotes rather
T4047 21592-21596 IN denotes than
T4048 21597-21598 DT denotes a
T4049 21599-21611 JJ denotes quantitative
T4045 21612-21618 NN denotes effect
T4050 21619-21621 IN denotes on
T4051 21622-21627 DT denotes these
T4052 21628-21638 NNS denotes phenotypes
T4053 21639-21641 FW denotes in
T4054 21642-21646 FW denotes vivo
T4055 21646-21647 . denotes .
T4056 21647-21796 sentence denotes In contrast, the level of XPCS mRNA expression did affect the ability of the encoded protein (XPDG602D) to restore the TTD hair phenotype to normal.
T4057 21648-21650 IN denotes In
T4059 21651-21659 NN denotes contrast
T4060 21659-21661 , denotes ,
T4061 21661-21664 DT denotes the
T4062 21665-21670 NN denotes level
T4063 21671-21673 IN denotes of
T4064 21674-21678 NN denotes XPCS
T4066 21679-21683 NN denotes mRNA
T4065 21684-21694 NN denotes expression
T4067 21695-21698 VBD denotes did
T4058 21699-21705 VB denotes affect
T4068 21706-21709 DT denotes the
T4069 21710-21717 NN denotes ability
T4070 21718-21720 IN denotes of
T4071 21721-21724 DT denotes the
T4073 21725-21732 VBN denotes encoded
T4072 21733-21740 NN denotes protein
T4074 21741-21742 -LRB- denotes (
T4075 21742-21750 NN denotes XPDG602D
T4076 21750-21751 -RRB- denotes )
T4077 21752-21754 TO denotes to
T4078 21755-21762 VB denotes restore
T4079 21763-21766 DT denotes the
T4081 21767-21770 NN denotes TTD
T4082 21771-21775 NN denotes hair
T4080 21776-21785 NN denotes phenotype
T4083 21786-21788 IN denotes to
T4084 21789-21795 JJ denotes normal
T4085 21795-21796 . denotes .
T4086 21796-22059 sentence denotes Notably, XpdTTD/ †XPCS animals had a partial TTD hair phenotype, correlating with low levels of Xpd†XPCS expression, whereas XpdTTD/XPCS animals had wt hair, correlating with normal expression levels from the viable XpdXPCS allele (Table 2 and unpublished data).
T4087 21797-21804 RB denotes Notably
T4089 21804-21806 , denotes ,
T4090 21806-21812 NN denotes XpdTTD
T4092 21812-21813 HYPH denotes /
T4091 21813-21819 NN denotes  †XPCS
T4093 21820-21827 NNS denotes animals
T4088 21828-21831 VBD denotes had
T4094 21832-21833 DT denotes a
T4096 21834-21841 JJ denotes partial
T4097 21842-21845 NN denotes TTD
T4098 21846-21850 NN denotes hair
T4095 21851-21860 NN denotes phenotype
T4099 21860-21862 , denotes ,
T4100 21862-21873 VBG denotes correlating
T4101 21874-21878 IN denotes with
T4102 21879-21882 JJ denotes low
T4103 21883-21889 NNS denotes levels
T4104 21890-21892 IN denotes of
T4105 21893-21901 NN denotes Xpd†XPCS
T4106 21902-21912 NN denotes expression
T4107 21912-21914 , denotes ,
T4108 21914-21921 IN denotes whereas
T4110 21922-21928 NN denotes XpdTTD
T4112 21928-21929 HYPH denotes /
T4111 21929-21933 NN denotes XPCS
T4113 21934-21941 NNS denotes animals
T4109 21942-21945 VBD denotes had
T4114 21946-21948 NN denotes wt
T4115 21949-21953 NN denotes hair
T4116 21953-21955 , denotes ,
T4117 21955-21966 VBG denotes correlating
T4118 21967-21971 IN denotes with
T4119 21972-21978 JJ denotes normal
T4121 21979-21989 NN denotes expression
T4120 21990-21996 NNS denotes levels
T4122 21997-22001 IN denotes from
T4123 22002-22005 DT denotes the
T4125 22006-22012 JJ denotes viable
T4126 22013-22020 NN denotes XpdXPCS
T4124 22021-22027 NN denotes allele
T4127 22028-22029 -LRB- denotes (
T4128 22029-22034 NN denotes Table
T4129 22035-22036 CD denotes 2
T4130 22037-22040 CC denotes and
T4131 22041-22052 JJ denotes unpublished
T4132 22053-22057 NNS denotes data
T4133 22057-22058 -RRB- denotes )
T4134 22058-22059 . denotes .
T4135 22059-22187 sentence denotes Thus, the range of expression levels from these two mutant alleles affected their ability to complement some phenotypes (hair).
T4136 22060-22064 RB denotes Thus
T4138 22064-22066 , denotes ,
T4139 22066-22069 DT denotes the
T4140 22070-22075 NN denotes range
T4141 22076-22078 IN denotes of
T4142 22079-22089 NN denotes expression
T4143 22090-22096 NNS denotes levels
T4144 22097-22101 IN denotes from
T4145 22102-22107 DT denotes these
T4147 22108-22111 CD denotes two
T4148 22112-22118 JJ denotes mutant
T4146 22119-22126 NNS denotes alleles
T4137 22127-22135 VBD denotes affected
T4149 22136-22141 PRP$ denotes their
T4150 22142-22149 NN denotes ability
T4151 22150-22152 TO denotes to
T4152 22153-22163 VB denotes complement
T4153 22164-22168 DT denotes some
T4154 22169-22179 NNS denotes phenotypes
T4155 22180-22181 -LRB- denotes (
T4156 22181-22185 NN denotes hair
T4157 22185-22186 -RRB- denotes )
T4158 22186-22187 . denotes .
T4159 22187-22350 sentence denotes An overview of the functional relationships between Xpd alleles, phenotypes, and the presumed underlying TFIIH function in mice and cells is presented in Table 2.
T4160 22188-22190 DT denotes An
T4161 22191-22199 NN denotes overview
T4163 22200-22202 IN denotes of
T4164 22203-22206 DT denotes the
T4166 22207-22217 JJ denotes functional
T4165 22218-22231 NNS denotes relationships
T4167 22232-22239 IN denotes between
T4168 22240-22243 NN denotes Xpd
T4169 22244-22251 NNS denotes alleles
T4170 22251-22253 , denotes ,
T4171 22253-22263 NNS denotes phenotypes
T4172 22263-22265 , denotes ,
T4173 22265-22268 CC denotes and
T4174 22269-22272 DT denotes the
T4176 22273-22281 VBN denotes presumed
T4177 22282-22292 VBG denotes underlying
T4178 22293-22298 NN denotes TFIIH
T4175 22299-22307 NN denotes function
T4179 22308-22310 IN denotes in
T4180 22311-22315 NNS denotes mice
T4181 22316-22319 CC denotes and
T4182 22320-22325 NNS denotes cells
T4183 22326-22328 VBZ denotes is
T4162 22329-22338 VBN denotes presented
T4184 22339-22341 IN denotes in
T4185 22342-22347 NN denotes Table
T4186 22348-22349 CD denotes 2
T4187 22349-22350 . denotes .
T4259 22364-22374 NN denotes Dissection
T4260 22375-22377 IN denotes of
T4261 22378-22387 JJ denotes Biallelic
T4262 22388-22395 NNS denotes Effects
T4263 22396-22400 IN denotes from
T4264 22401-22406 JJ denotes other
T4265 22407-22419 NNS denotes Determinants
T4266 22420-22422 IN denotes of
T4267 22423-22432 NN denotes Phenotype
T4268 22432-22724 sentence denotes Although phenotypic consequences, referred to here as biallelic effects, resulting from two different mutant alleles in compound heterozygote patients have been postulated, such effects have historically been difficult to distinguish from the influence of environment and genetic background.
T4269 22433-22441 IN denotes Although
T4271 22442-22452 JJ denotes phenotypic
T4272 22453-22465 NNS denotes consequences
T4273 22465-22467 , denotes ,
T4274 22467-22475 VBN denotes referred
T4275 22476-22478 IN denotes to
T4276 22479-22483 RB denotes here
T4277 22484-22486 IN denotes as
T4278 22487-22496 JJ denotes biallelic
T4279 22497-22504 NNS denotes effects
T4280 22504-22506 , denotes ,
T4281 22506-22515 VBG denotes resulting
T4282 22516-22520 IN denotes from
T4283 22521-22524 CD denotes two
T4285 22525-22534 JJ denotes different
T4286 22535-22541 JJ denotes mutant
T4284 22542-22549 NNS denotes alleles
T4287 22550-22552 IN denotes in
T4288 22553-22561 NN denotes compound
T4290 22562-22574 NN denotes heterozygote
T4289 22575-22583 NNS denotes patients
T4291 22584-22588 VBP denotes have
T4292 22589-22593 VBN denotes been
T4270 22594-22604 VBN denotes postulated
T4294 22604-22606 , denotes ,
T4295 22606-22610 JJ denotes such
T4296 22611-22618 NNS denotes effects
T4297 22619-22623 VBP denotes have
T4298 22624-22636 RB denotes historically
T4293 22637-22641 VBN denotes been
T4299 22642-22651 JJ denotes difficult
T4300 22652-22654 TO denotes to
T4301 22655-22666 VB denotes distinguish
T4302 22667-22671 IN denotes from
T4303 22672-22675 DT denotes the
T4304 22676-22685 NN denotes influence
T4305 22686-22688 IN denotes of
T4306 22689-22700 NN denotes environment
T4307 22701-22704 CC denotes and
T4308 22705-22712 JJ denotes genetic
T4309 22713-22723 NN denotes background
T4310 22723-22724 . denotes .
T4311 22724-22929 sentence denotes We used a genetically defined mammalian model system under controlled environmental conditions to reveal phenotypic effects attributable specifically to combinations of differentially mutated Xpd alleles.
T4312 22725-22727 PRP denotes We
T4313 22728-22732 VBD denotes used
T4314 22733-22734 DT denotes a
T4316 22735-22746 RB denotes genetically
T4317 22747-22754 VBN denotes defined
T4318 22755-22764 JJ denotes mammalian
T4319 22765-22770 NN denotes model
T4315 22771-22777 NN denotes system
T4320 22778-22783 IN denotes under
T4321 22784-22794 JJ denotes controlled
T4323 22795-22808 JJ denotes environmental
T4322 22809-22819 NNS denotes conditions
T4324 22820-22822 TO denotes to
T4325 22823-22829 VB denotes reveal
T4326 22830-22840 JJ denotes phenotypic
T4327 22841-22848 NNS denotes effects
T4328 22849-22861 JJ denotes attributable
T4329 22862-22874 RB denotes specifically
T4330 22875-22877 IN denotes to
T4331 22878-22890 NNS denotes combinations
T4332 22891-22893 IN denotes of
T4333 22894-22908 RB denotes differentially
T4334 22909-22916 VBN denotes mutated
T4336 22917-22920 NN denotes Xpd
T4335 22921-22928 NNS denotes alleles
T4337 22928-22929 . denotes .
T4338 22929-22989 sentence denotes The observed biallelic effects were of three general types.
T4339 22930-22933 DT denotes The
T4341 22934-22942 VBN denotes observed
T4342 22943-22952 JJ denotes biallelic
T4340 22953-22960 NNS denotes effects
T4343 22961-22965 VBD denotes were
T4344 22966-22968 IN denotes of
T4345 22969-22974 CD denotes three
T4347 22975-22982 JJ denotes general
T4346 22983-22988 NNS denotes types
T4348 22988-22989 . denotes .
T4349 22989-23177 sentence denotes In the first, the allele associated in a homozygous state with a phenotype closer to wt singularly determined the phenotypic outcome, a phenomenon widely known in human recessive disease.
T4350 22990-22992 IN denotes In
T4352 22993-22996 DT denotes the
T4353 22997-23002 JJ denotes first
T4354 23002-23004 , denotes ,
T4355 23004-23007 DT denotes the
T4356 23008-23014 NN denotes allele
T4357 23015-23025 VBN denotes associated
T4358 23026-23028 IN denotes in
T4359 23029-23030 DT denotes a
T4361 23031-23041 JJ denotes homozygous
T4360 23042-23047 NN denotes state
T4362 23048-23052 IN denotes with
T4363 23053-23054 DT denotes a
T4364 23055-23064 NN denotes phenotype
T4365 23065-23071 RBR denotes closer
T4366 23072-23074 IN denotes to
T4367 23075-23077 NN denotes wt
T4368 23078-23088 RB denotes singularly
T4351 23089-23099 VBN denotes determined
T4369 23100-23103 DT denotes the
T4371 23104-23114 JJ denotes phenotypic
T4370 23115-23122 NN denotes outcome
T4372 23122-23124 , denotes ,
T4373 23124-23125 DT denotes a
T4374 23126-23136 NN denotes phenomenon
T4375 23137-23143 RB denotes widely
T4376 23144-23149 VBN denotes known
T4377 23150-23152 IN denotes in
T4378 23153-23158 JJ denotes human
T4380 23159-23168 JJ denotes recessive
T4379 23169-23176 NN denotes disease
T4381 23176-23177 . denotes .
T4382 23177-23308 sentence denotes Because these Xpd alleles functioned at or near wt levels with respect to a particular function, we call these effects “dominant”.
T4383 23178-23185 IN denotes Because
T4385 23186-23191 DT denotes these
T4387 23192-23195 NN denotes Xpd
T4386 23196-23203 NNS denotes alleles
T4384 23204-23214 VBD denotes functioned
T4389 23215-23217 IN denotes at
T4390 23218-23220 CC denotes or
T4391 23221-23225 IN denotes near
T4392 23226-23228 NN denotes wt
T4393 23229-23235 NNS denotes levels
T4394 23236-23240 IN denotes with
T4395 23241-23248 NN denotes respect
T4396 23249-23251 IN denotes to
T4397 23252-23253 DT denotes a
T4399 23254-23264 JJ denotes particular
T4398 23265-23273 NN denotes function
T4400 23273-23275 , denotes ,
T4401 23275-23277 PRP denotes we
T4388 23278-23282 VBP denotes call
T4402 23283-23288 DT denotes these
T4403 23289-23296 NNS denotes effects
T4404 23297-23298 `` denotes “
T4405 23298-23306 JJ denotes dominant
T4406 23306-23307 '' denotes ”
T4407 23307-23308 . denotes .
T4408 23308-23477 sentence denotes Such alleles can also be referred to as “separation of function” alleles, because they allow dissection of the roles of multifunctional proteins in specific phenotypes.
T4409 23309-23313 JJ denotes Such
T4410 23314-23321 NNS denotes alleles
T4412 23322-23325 MD denotes can
T4413 23326-23330 RB denotes also
T4414 23331-23333 VB denotes be
T4411 23334-23342 VBN denotes referred
T4415 23343-23345 IN denotes to
T4416 23346-23348 IN denotes as
T4417 23349-23350 `` denotes “
T4419 23350-23360 NN denotes separation
T4420 23361-23363 IN denotes of
T4421 23364-23372 NN denotes function
T4422 23372-23373 '' denotes ”
T4418 23374-23381 NNS denotes alleles
T4423 23381-23383 , denotes ,
T4424 23383-23390 IN denotes because
T4426 23391-23395 PRP denotes they
T4425 23396-23401 VBP denotes allow
T4427 23402-23412 NN denotes dissection
T4428 23413-23415 IN denotes of
T4429 23416-23419 DT denotes the
T4430 23420-23425 NNS denotes roles
T4431 23426-23428 IN denotes of
T4432 23429-23444 JJ denotes multifunctional
T4433 23445-23453 NN denotes proteins
T4434 23454-23456 IN denotes in
T4435 23457-23465 JJ denotes specific
T4436 23466-23476 NNS denotes phenotypes
T4437 23476-23477 . denotes .
T4438 23477-23854 sentence denotes Secondly, highlighting the potential relevance of current findings to all diploid organisms including humans was the observation that in one compound heterozygous animal, the Xpd allelic relationship could shift from A dominant |a recessive to A recessive |a dominant with respect to different phenotypes in a time-dependent and tissue-specific manner (see below and Table 2).
T4439 23478-23486 RB denotes Secondly
T4441 23486-23488 , denotes ,
T4442 23488-23500 VBG denotes highlighting
T4443 23501-23504 DT denotes the
T4445 23505-23514 JJ denotes potential
T4444 23515-23524 NN denotes relevance
T4446 23525-23527 IN denotes of
T4447 23528-23535 JJ denotes current
T4448 23536-23544 NNS denotes findings
T4449 23545-23547 IN denotes to
T4450 23548-23551 DT denotes all
T4452 23552-23559 JJ denotes diploid
T4451 23560-23569 NNS denotes organisms
T4453 23570-23579 VBG denotes including
T4454 23580-23586 NNS denotes humans
T4440 23587-23590 VBD denotes was
T4455 23591-23594 DT denotes the
T4456 23595-23606 NN denotes observation
T4457 23607-23611 IN denotes that
T4459 23612-23614 IN denotes in
T4460 23615-23618 CD denotes one
T4462 23619-23627 NN denotes compound
T4463 23628-23640 JJ denotes heterozygous
T4461 23641-23647 NN denotes animal
T4464 23647-23649 , denotes ,
T4465 23649-23652 DT denotes the
T4467 23653-23656 NN denotes Xpd
T4468 23657-23664 JJ denotes allelic
T4466 23665-23677 NN denotes relationship
T4469 23678-23683 MD denotes could
T4458 23684-23689 VB denotes shift
T4470 23690-23694 IN denotes from
T4471 23695-23705 JJ denotes A dominant
T4473 23706-23707 HYPH denotes |
T4472 23707-23718 JJ denotes a recessive
T4474 23719-23721 IN denotes to
T4475 23722-23733 JJ denotes A recessive
T4477 23734-23735 HYPH denotes |
T4476 23735-23745 JJ denotes a dominant
T4478 23746-23750 IN denotes with
T4479 23751-23758 NN denotes respect
T4480 23759-23761 IN denotes to
T4481 23762-23771 JJ denotes different
T4482 23772-23782 NNS denotes phenotypes
T4483 23783-23785 IN denotes in
T4484 23786-23787 DT denotes a
T4486 23788-23792 NN denotes time
T4488 23792-23793 HYPH denotes -
T4487 23793-23802 JJ denotes dependent
T4489 23803-23806 CC denotes and
T4490 23807-23813 NN denotes tissue
T4492 23813-23814 HYPH denotes -
T4491 23814-23822 JJ denotes specific
T4485 23823-23829 NN denotes manner
T4493 23830-23831 -LRB- denotes (
T4494 23831-23834 VB denotes see
T4495 23835-23840 RB denotes below
T4497 23841-23844 CC denotes and
T4496 23845-23850 NN denotes Table
T4498 23851-23852 CD denotes 2
T4499 23852-23853 -RRB- denotes )
T4500 23853-23854 . denotes .
T4501 23854-24041 sentence denotes In the third type of biallelic effect, known as interallelic complementation, two mutant alleles produced a phenotype closer to wt than either could alone in a homo- or hemizygous state.
T4502 23855-23857 IN denotes In
T4504 23858-23861 DT denotes the
T4506 23862-23867 JJ denotes third
T4505 23868-23872 NN denotes type
T4507 23873-23875 IN denotes of
T4508 23876-23885 JJ denotes biallelic
T4509 23886-23892 NN denotes effect
T4510 23892-23894 , denotes ,
T4511 23894-23899 VBN denotes known
T4512 23900-23902 IN denotes as
T4513 23903-23915 JJ denotes interallelic
T4514 23916-23931 NN denotes complementation
T4515 23931-23933 , denotes ,
T4516 23933-23936 CD denotes two
T4518 23937-23943 JJ denotes mutant
T4517 23944-23951 NNS denotes alleles
T4503 23952-23960 VBD denotes produced
T4519 23961-23962 DT denotes a
T4520 23963-23972 NN denotes phenotype
T4521 23973-23979 RBR denotes closer
T4522 23980-23982 IN denotes to
T4523 23983-23985 NN denotes wt
T4524 23986-23990 IN denotes than
T4526 23991-23997 DT denotes either
T4527 23998-24003 MD denotes could
T4525 24004-24009 RB denotes alone
T4528 24010-24012 IN denotes in
T4529 24013-24014 DT denotes a
T4531 24015-24019 AFX denotes homo
T4533 24019-24020 HYPH denotes -
T4534 24021-24023 CC denotes or
T4532 24024-24034 JJ denotes hemizygous
T4530 24035-24040 NN denotes state
T4535 24040-24041 . denotes .
T4536 24041-24216 sentence denotes As summarised in Table 2, examples of all types of biallelic effects were observed in a variety of Xpd-associated phenotypes, ranging from brittle hair to segmental progeria.
T4537 24042-24044 IN denotes As
T4538 24045-24055 VBN denotes summarised
T4540 24056-24058 IN denotes in
T4541 24059-24064 NN denotes Table
T4542 24065-24066 CD denotes 2
T4543 24066-24068 , denotes ,
T4544 24068-24076 NNS denotes examples
T4545 24077-24079 IN denotes of
T4546 24080-24083 DT denotes all
T4547 24084-24089 NNS denotes types
T4548 24090-24092 IN denotes of
T4549 24093-24102 JJ denotes biallelic
T4550 24103-24110 NNS denotes effects
T4551 24111-24115 VBD denotes were
T4539 24116-24124 VBN denotes observed
T4552 24125-24127 IN denotes in
T4553 24128-24129 DT denotes a
T4554 24130-24137 NN denotes variety
T4555 24138-24140 IN denotes of
T4556 24141-24144 NN denotes Xpd
T4558 24144-24145 HYPH denotes -
T4557 24145-24155 VBN denotes associated
T4559 24156-24166 NNS denotes phenotypes
T4560 24166-24168 , denotes ,
T4561 24168-24175 VBG denotes ranging
T4562 24176-24180 IN denotes from
T4563 24181-24188 JJ denotes brittle
T4564 24189-24193 NN denotes hair
T4565 24194-24196 IN denotes to
T4566 24197-24206 JJ denotes segmental
T4567 24207-24215 NN denotes progeria
T4568 24215-24216 . denotes .
T4805 24218-24223 NN denotes TFIIH
T4806 24224-24226 IN denotes in
T4807 24227-24240 NN denotes Transcription
T4808 24241-24244 CC denotes and
T4809 24245-24251 NN denotes Repair
T4810 24251-24253 : denotes :
T4811 24253-24263 NNS denotes Mechanisms
T4812 24264-24266 IN denotes of
T4813 24267-24270 NN denotes XPD
T4815 24271-24278 NN denotes Disease
T4814 24279-24289 NN denotes Pleiotropy
T4816 24289-24579 sentence denotes We observed differences in the ability of XpdTTD versus homozygous lethal Xpd†XPCS and Xpd†XP alleles to function in two transcription-related phenotypes separated in the organism by both time and space: embryonic lethality and terminal differentiation of enucleating skin and blood cells.
T4817 24290-24292 PRP denotes We
T4818 24293-24301 VBD denotes observed
T4819 24302-24313 NNS denotes differences
T4820 24314-24316 IN denotes in
T4821 24317-24320 DT denotes the
T4822 24321-24328 NN denotes ability
T4823 24329-24331 IN denotes of
T4824 24332-24338 NN denotes XpdTTD
T4825 24339-24345 CC denotes versus
T4826 24346-24356 JJ denotes homozygous
T4828 24357-24363 JJ denotes lethal
T4829 24364-24372 NN denotes Xpd†XPCS
T4830 24373-24376 CC denotes and
T4831 24377-24383 NN denotes Xpd†XP
T4827 24384-24391 NNS denotes alleles
T4832 24392-24394 TO denotes to
T4833 24395-24403 VB denotes function
T4834 24404-24406 IN denotes in
T4835 24407-24410 CD denotes two
T4837 24411-24424 NN denotes transcription
T4839 24424-24425 HYPH denotes -
T4838 24425-24432 VBN denotes related
T4836 24433-24443 NNS denotes phenotypes
T4840 24444-24453 VBN denotes separated
T4841 24454-24456 IN denotes in
T4842 24457-24460 DT denotes the
T4843 24461-24469 NN denotes organism
T4844 24470-24472 IN denotes by
T4845 24473-24477 CC denotes both
T4846 24478-24482 NN denotes time
T4847 24483-24486 CC denotes and
T4848 24487-24492 NN denotes space
T4849 24492-24494 : denotes :
T4850 24494-24503 JJ denotes embryonic
T4851 24504-24513 NN denotes lethality
T4852 24514-24517 CC denotes and
T4853 24518-24526 JJ denotes terminal
T4854 24527-24542 NN denotes differentiation
T4855 24543-24545 IN denotes of
T4856 24546-24557 VBG denotes enucleating
T4857 24558-24562 NN denotes skin
T4858 24563-24566 CC denotes and
T4859 24567-24572 NN denotes blood
T4860 24573-24578 NNS denotes cells
T4861 24578-24579 . denotes .
T4862 24579-24759 sentence denotes The preblastocyst-stage homozygous lethality shared by the XpdKO, Xpd†XPCS, and Xpd†XP alleles most likely reflects a defect in basal transcription that is incompatible with life.
T4863 24580-24583 DT denotes The
T4865 24584-24597 NN denotes preblastocyst
T4867 24597-24598 HYPH denotes -
T4866 24598-24603 NN denotes stage
T4868 24604-24614 JJ denotes homozygous
T4864 24615-24624 NN denotes lethality
T4870 24625-24631 VBN denotes shared
T4871 24632-24634 IN denotes by
T4872 24635-24638 DT denotes the
T4874 24639-24644 NN denotes XpdKO
T4875 24644-24646 , denotes ,
T4876 24646-24654 NN denotes Xpd†XPCS
T4877 24654-24656 , denotes ,
T4878 24656-24659 CC denotes and
T4879 24660-24666 NN denotes Xpd†XP
T4873 24667-24674 NNS denotes alleles
T4880 24675-24679 RBS denotes most
T4881 24680-24686 RB denotes likely
T4869 24687-24695 VBZ denotes reflects
T4882 24696-24697 DT denotes a
T4883 24698-24704 NN denotes defect
T4884 24705-24707 IN denotes in
T4885 24708-24713 JJ denotes basal
T4886 24714-24727 NN denotes transcription
T4887 24728-24732 WDT denotes that
T4888 24733-24735 VBZ denotes is
T4889 24736-24748 JJ denotes incompatible
T4890 24749-24753 IN denotes with
T4891 24754-24758 NN denotes life
T4892 24758-24759 . denotes .
T4893 24759-24880 sentence denotes In XpdTTD/ †XPCS and XpdTTD/ †XP compound heterozygous mice, embryonic lethality was fully rescued by the XpdTTD allele.
T4894 24760-24762 IN denotes In
T4896 24763-24769 NN denotes XpdTTD
T4898 24769-24770 HYPH denotes /
T4897 24770-24776 NN denotes  †XPCS
T4900 24777-24780 CC denotes and
T4901 24781-24787 NN denotes XpdTTD
T4903 24787-24788 HYPH denotes /
T4902 24788-24792 NN denotes  †XP
T4904 24793-24801 NN denotes compound
T4905 24802-24814 JJ denotes heterozygous
T4899 24815-24819 NNS denotes mice
T4906 24819-24821 , denotes ,
T4907 24821-24830 JJ denotes embryonic
T4908 24831-24840 NN denotes lethality
T4909 24841-24844 VBD denotes was
T4910 24845-24850 RB denotes fully
T4895 24851-24858 VBN denotes rescued
T4911 24859-24861 IN denotes by
T4912 24862-24865 DT denotes the
T4914 24866-24872 NN denotes XpdTTD
T4913 24873-24879 NN denotes allele
T4915 24879-24880 . denotes .
T4916 24880-25145 sentence denotes Because embryonic lethality was also fully rescued in XpdTTD/KO hemizygous mice, the XpdTTD allele can be considered as wt and thus dominant to each of the homozygous lethal alleles (XpdKO, Xpd†XPCS, and Xpd†XP) with respect to this particular phenotype (Table 2).
T4917 24881-24888 IN denotes Because
T4919 24889-24898 JJ denotes embryonic
T4920 24899-24908 NN denotes lethality
T4921 24909-24912 VBD denotes was
T4922 24913-24917 RB denotes also
T4923 24918-24923 RB denotes fully
T4918 24924-24931 VBN denotes rescued
T4925 24932-24934 IN denotes in
T4926 24935-24941 NN denotes XpdTTD
T4928 24941-24942 HYPH denotes /
T4927 24942-24944 NN denotes KO
T4930 24945-24955 JJ denotes hemizygous
T4929 24956-24960 NNS denotes mice
T4931 24960-24962 , denotes ,
T4932 24962-24965 DT denotes the
T4934 24966-24972 NN denotes XpdTTD
T4933 24973-24979 NN denotes allele
T4935 24980-24983 MD denotes can
T4936 24984-24986 VB denotes be
T4924 24987-24997 VBN denotes considered
T4937 24998-25000 IN denotes as
T4938 25001-25003 NN denotes wt
T4939 25004-25007 CC denotes and
T4940 25008-25012 RB denotes thus
T4941 25013-25021 JJ denotes dominant
T4942 25022-25024 IN denotes to
T4943 25025-25029 DT denotes each
T4944 25030-25032 IN denotes of
T4945 25033-25036 DT denotes the
T4947 25037-25047 JJ denotes homozygous
T4948 25048-25054 JJ denotes lethal
T4946 25055-25062 NNS denotes alleles
T4949 25063-25064 -LRB- denotes (
T4950 25064-25069 NN denotes XpdKO
T4951 25069-25071 , denotes ,
T4952 25071-25079 NN denotes Xpd†XPCS
T4953 25079-25081 , denotes ,
T4954 25081-25084 CC denotes and
T4955 25085-25091 NN denotes Xpd†XP
T4956 25091-25092 -RRB- denotes )
T4957 25093-25097 IN denotes with
T4958 25098-25105 NN denotes respect
T4959 25106-25108 IN denotes to
T4960 25109-25113 DT denotes this
T4962 25114-25124 JJ denotes particular
T4961 25125-25134 NN denotes phenotype
T4963 25135-25136 -LRB- denotes (
T4964 25136-25141 NN denotes Table
T4965 25142-25143 CD denotes 2
T4966 25143-25144 -RRB- denotes )
T4967 25144-25145 . denotes .
T4968 25145-25405 sentence denotes TTD-specific cutaneous and anaemic features, on the other hand, are thought to result from a specific kind of transcriptional insufficiency caused by depletion of unstable TFIIH during the terminal differentiation of skin, hair-shaft, and blood cells [16,24].
T4969 25146-25149 NN denotes TTD
T4971 25149-25150 HYPH denotes -
T4970 25150-25158 JJ denotes specific
T4973 25159-25168 JJ denotes cutaneous
T4974 25169-25172 CC denotes and
T4975 25173-25180 JJ denotes anaemic
T4972 25181-25189 NNS denotes features
T4977 25189-25191 , denotes ,
T4978 25191-25193 IN denotes on
T4979 25194-25197 DT denotes the
T4981 25198-25203 JJ denotes other
T4980 25204-25208 NN denotes hand
T4982 25208-25210 , denotes ,
T4983 25210-25213 VBP denotes are
T4976 25214-25221 VBN denotes thought
T4984 25222-25224 TO denotes to
T4985 25225-25231 VB denotes result
T4986 25232-25236 IN denotes from
T4987 25237-25238 DT denotes a
T4989 25239-25247 JJ denotes specific
T4988 25248-25252 NN denotes kind
T4990 25253-25255 IN denotes of
T4991 25256-25271 JJ denotes transcriptional
T4992 25272-25285 NN denotes insufficiency
T4993 25286-25292 VBN denotes caused
T4994 25293-25295 IN denotes by
T4995 25296-25305 NN denotes depletion
T4996 25306-25308 IN denotes of
T4997 25309-25317 JJ denotes unstable
T4998 25318-25323 NN denotes TFIIH
T4999 25324-25330 IN denotes during
T5000 25331-25334 DT denotes the
T5002 25335-25343 JJ denotes terminal
T5001 25344-25359 NN denotes differentiation
T5003 25360-25362 IN denotes of
T5004 25363-25367 NN denotes skin
T5006 25367-25369 , denotes ,
T5007 25369-25373 NN denotes hair
T5009 25373-25374 HYPH denotes -
T5008 25374-25379 NN denotes shaft
T5010 25379-25381 , denotes ,
T5011 25381-25384 CC denotes and
T5012 25385-25390 NN denotes blood
T5005 25391-25396 NNS denotes cells
T5013 25397-25398 -LRB- denotes [
T5015 25398-25400 CD denotes 16
T5016 25400-25401 , denotes ,
T5014 25401-25403 CD denotes 24
T5017 25403-25404 -RRB- denotes ]
T5018 25404-25405 . denotes .
T5019 25405-25650 sentence denotes In compound heterozygous mice, both homozygous lethal Xpd†XPCS and Xpd†XP alleles were able to alleviate XpdTTD-specific cutaneous and anaemic features and can thus be defined as dominant over the XpdTTD allele with respect to these phenotypes.
T5020 25406-25408 IN denotes In
T5022 25409-25417 NN denotes compound
T5024 25418-25430 JJ denotes heterozygous
T5023 25431-25435 NNS denotes mice
T5025 25435-25437 , denotes ,
T5026 25437-25441 DT denotes both
T5028 25442-25452 JJ denotes homozygous
T5029 25453-25459 JJ denotes lethal
T5030 25460-25468 NN denotes Xpd†XPCS
T5031 25469-25472 CC denotes and
T5032 25473-25479 NN denotes Xpd†XP
T5027 25480-25487 NNS denotes alleles
T5021 25488-25492 VBD denotes were
T5033 25493-25497 JJ denotes able
T5034 25498-25500 TO denotes to
T5035 25501-25510 VB denotes alleviate
T5036 25511-25517 NN denotes XpdTTD
T5038 25517-25518 HYPH denotes -
T5037 25518-25526 JJ denotes specific
T5040 25527-25536 JJ denotes cutaneous
T5041 25537-25540 CC denotes and
T5042 25541-25548 JJ denotes anaemic
T5039 25549-25557 NNS denotes features
T5043 25558-25561 CC denotes and
T5044 25562-25565 MD denotes can
T5046 25566-25570 RB denotes thus
T5047 25571-25573 VB denotes be
T5045 25574-25581 VBN denotes defined
T5048 25582-25584 IN denotes as
T5049 25585-25593 JJ denotes dominant
T5050 25594-25598 IN denotes over
T5051 25599-25602 DT denotes the
T5053 25603-25609 NN denotes XpdTTD
T5052 25610-25616 NN denotes allele
T5054 25617-25621 IN denotes with
T5055 25622-25629 NN denotes respect
T5056 25630-25632 IN denotes to
T5057 25633-25638 DT denotes these
T5058 25639-25649 NNS denotes phenotypes
T5059 25649-25650 . denotes .
T5060 25650-25867 sentence denotes We conclude that the defects leading to embryonic lethality and aberrant terminal differentiation of the skin, hair, and blood represent two qualitatively and/or quantitatively different transcriptional deficiencies.
T5061 25651-25653 PRP denotes We
T5062 25654-25662 VBP denotes conclude
T5063 25663-25667 IN denotes that
T5065 25668-25671 DT denotes the
T5066 25672-25679 NNS denotes defects
T5067 25680-25687 VBG denotes leading
T5068 25688-25690 IN denotes to
T5069 25691-25700 JJ denotes embryonic
T5070 25701-25710 NN denotes lethality
T5071 25711-25714 CC denotes and
T5072 25715-25723 JJ denotes aberrant
T5074 25724-25732 JJ denotes terminal
T5073 25733-25748 NN denotes differentiation
T5075 25749-25751 IN denotes of
T5076 25752-25755 DT denotes the
T5077 25756-25760 NN denotes skin
T5078 25760-25762 , denotes ,
T5079 25762-25766 NN denotes hair
T5080 25766-25768 , denotes ,
T5081 25768-25771 CC denotes and
T5082 25772-25777 NN denotes blood
T5064 25778-25787 VBP denotes represent
T5083 25788-25791 CD denotes two
T5085 25792-25805 RB denotes qualitatively
T5087 25806-25809 CC denotes and
T5088 25809-25810 HYPH denotes /
T5089 25810-25812 CC denotes or
T5090 25813-25827 RB denotes quantitatively
T5086 25828-25837 JJ denotes different
T5091 25838-25853 JJ denotes transcriptional
T5084 25854-25866 NNS denotes deficiencies
T5092 25866-25867 . denotes .
T5093 25867-26058 sentence denotes During early embryonic development, XpdTTD is dominant over the Xpd†XPCS and Xpd†XP alleles, whereas later in the ontogenesis of skin, hair-shaft, and blood cells, the situation is reversed.
T5094 25868-25874 IN denotes During
T5096 25875-25880 JJ denotes early
T5098 25881-25890 JJ denotes embryonic
T5097 25891-25902 NN denotes development
T5099 25902-25904 , denotes ,
T5100 25904-25910 NN denotes XpdTTD
T5095 25911-25913 VBZ denotes is
T5101 25914-25922 JJ denotes dominant
T5102 25923-25927 IN denotes over
T5103 25928-25931 DT denotes the
T5105 25932-25940 NN denotes Xpd†XPCS
T5106 25941-25944 CC denotes and
T5107 25945-25951 NN denotes Xpd†XP
T5104 25952-25959 NNS denotes alleles
T5108 25959-25961 , denotes ,
T5109 25961-25968 IN denotes whereas
T5111 25969-25974 RB denotes later
T5112 25975-25977 IN denotes in
T5113 25978-25981 DT denotes the
T5114 25982-25993 NN denotes ontogenesis
T5115 25994-25996 IN denotes of
T5116 25997-26001 NN denotes skin
T5117 26001-26003 , denotes ,
T5118 26003-26007 NN denotes hair
T5120 26007-26008 HYPH denotes -
T5119 26008-26013 NN denotes shaft
T5121 26013-26015 , denotes ,
T5122 26015-26018 CC denotes and
T5123 26019-26024 NN denotes blood
T5124 26025-26030 NNS denotes cells
T5125 26030-26032 , denotes ,
T5126 26032-26035 DT denotes the
T5127 26036-26045 NN denotes situation
T5128 26046-26048 VBZ denotes is
T5110 26049-26057 VBN denotes reversed
T5129 26057-26058 . denotes .
T5130 26058-26301 sentence denotes In its role in the repair of UV photolesions, the Xpd†XPCS allele imparted a clear UV survival benefit over a single XpdTTD allele or two XpdXPCS alleles independent of expression levels, which is consistent with interallelic complementation.
T5131 26059-26061 IN denotes In
T5133 26062-26065 PRP$ denotes its
T5134 26066-26070 NN denotes role
T5135 26071-26073 IN denotes in
T5136 26074-26077 DT denotes the
T5137 26078-26084 NN denotes repair
T5138 26085-26087 IN denotes of
T5139 26088-26090 NN denotes UV
T5140 26091-26103 NNS denotes photolesions
T5141 26103-26105 , denotes ,
T5142 26105-26108 DT denotes the
T5144 26109-26117 NN denotes Xpd†XPCS
T5143 26118-26124 NN denotes allele
T5132 26125-26133 VBD denotes imparted
T5145 26134-26135 DT denotes a
T5147 26136-26141 JJ denotes clear
T5148 26142-26144 NN denotes UV
T5149 26145-26153 NN denotes survival
T5146 26154-26161 NN denotes benefit
T5150 26162-26166 IN denotes over
T5151 26167-26168 DT denotes a
T5153 26169-26175 JJ denotes single
T5154 26176-26182 NN denotes XpdTTD
T5152 26183-26189 NN denotes allele
T5155 26190-26192 CC denotes or
T5156 26193-26196 CD denotes two
T5158 26197-26204 NN denotes XpdXPCS
T5157 26205-26212 NNS denotes alleles
T5159 26213-26224 JJ denotes independent
T5160 26225-26227 IN denotes of
T5161 26228-26238 NN denotes expression
T5162 26239-26245 NNS denotes levels
T5163 26245-26247 , denotes ,
T5164 26247-26252 WDT denotes which
T5165 26253-26255 VBZ denotes is
T5166 26256-26266 JJ denotes consistent
T5167 26267-26271 IN denotes with
T5168 26272-26284 JJ denotes interallelic
T5169 26285-26300 NN denotes complementation
T5170 26300-26301 . denotes .
T5171 26301-26521 sentence denotes However, the observation that no other cellular or biochemical UV-related parameters were improved in XpdTTD/ †XPCS argues against complementation of this repair activity in the rescue of TTD progeroid symptoms in vivo.
T5172 26302-26309 RB denotes However
T5174 26309-26311 , denotes ,
T5175 26311-26314 DT denotes the
T5176 26315-26326 NN denotes observation
T5177 26327-26331 IN denotes that
T5179 26332-26334 DT denotes no
T5181 26335-26340 JJ denotes other
T5182 26341-26349 JJ denotes cellular
T5183 26350-26352 CC denotes or
T5184 26353-26364 JJ denotes biochemical
T5185 26365-26367 NN denotes UV
T5187 26367-26368 HYPH denotes -
T5186 26368-26375 VBN denotes related
T5180 26376-26386 NNS denotes parameters
T5188 26387-26391 VBD denotes were
T5178 26392-26400 VBN denotes improved
T5189 26401-26403 IN denotes in
T5190 26404-26410 NN denotes XpdTTD
T5192 26410-26411 HYPH denotes /
T5191 26411-26417 NN denotes  †XPCS
T5173 26418-26424 VBZ denotes argues
T5193 26425-26432 IN denotes against
T5194 26433-26448 NN denotes complementation
T5195 26449-26451 IN denotes of
T5196 26452-26456 DT denotes this
T5198 26457-26463 NN denotes repair
T5197 26464-26472 NN denotes activity
T5199 26473-26475 IN denotes in
T5200 26476-26479 DT denotes the
T5201 26480-26486 NN denotes rescue
T5202 26487-26489 IN denotes of
T5203 26490-26493 NN denotes TTD
T5205 26494-26503 JJ denotes progeroid
T5204 26504-26512 NNS denotes symptoms
T5206 26513-26515 FW denotes in
T5207 26516-26520 FW denotes vivo
T5208 26520-26521 . denotes .
T5295 26523-26535 JJ denotes Interallelic
T5296 26536-26551 NN denotes Complementation
T5297 26552-26555 CC denotes and
T5298 26556-26559 NN denotes XPD
T5299 26560-26568 NN denotes Function
T5300 26568-26652 sentence denotes What does interallelic complementation tell us about the mechanism of XPD function?
T5301 26569-26573 WP denotes What
T5303 26574-26578 VBZ denotes does
T5304 26579-26591 JJ denotes interallelic
T5305 26592-26607 NN denotes complementation
T5302 26608-26612 VB denotes tell
T5306 26613-26615 PRP denotes us
T5307 26616-26621 IN denotes about
T5308 26622-26625 DT denotes the
T5309 26626-26635 NN denotes mechanism
T5310 26636-26638 IN denotes of
T5311 26639-26642 NN denotes XPD
T5312 26643-26651 NN denotes function
T5313 26651-26652 . denotes ?
T5314 26652-26761 sentence denotes Interallelic complementation is most often observed in multimeric proteins with multiple functional domains.
T5315 26653-26665 JJ denotes Interallelic
T5316 26666-26681 NN denotes complementation
T5318 26682-26684 VBZ denotes is
T5319 26685-26689 RBS denotes most
T5320 26690-26695 RB denotes often
T5317 26696-26704 VBN denotes observed
T5321 26705-26707 IN denotes in
T5322 26708-26718 JJ denotes multimeric
T5323 26719-26727 NN denotes proteins
T5324 26728-26732 IN denotes with
T5325 26733-26741 JJ denotes multiple
T5327 26742-26752 JJ denotes functional
T5326 26753-26760 NNS denotes domains
T5328 26760-26761 . denotes .
T5329 26761-26980 sentence denotes Unfortunately, the structure–function relationship between disease-causing mutations and XPD functional domains, including detailed structural information on XPD or even its stoichiometry within TFIIH, remains unknown.
T5330 26762-26775 RB denotes Unfortunately
T5332 26775-26777 , denotes ,
T5333 26777-26780 DT denotes the
T5335 26781-26790 NN denotes structure
T5337 26790-26791 HYPH denotes –
T5336 26791-26799 NN denotes function
T5334 26800-26812 NN denotes relationship
T5338 26813-26820 IN denotes between
T5339 26821-26828 NN denotes disease
T5341 26828-26829 HYPH denotes -
T5340 26829-26836 VBG denotes causing
T5342 26837-26846 NNS denotes mutations
T5343 26847-26850 CC denotes and
T5344 26851-26854 NN denotes XPD
T5346 26855-26865 JJ denotes functional
T5345 26866-26873 NNS denotes domains
T5347 26873-26875 , denotes ,
T5348 26875-26884 VBG denotes including
T5349 26885-26893 JJ denotes detailed
T5351 26894-26904 JJ denotes structural
T5350 26905-26916 NN denotes information
T5352 26917-26919 IN denotes on
T5353 26920-26923 NN denotes XPD
T5354 26924-26926 CC denotes or
T5355 26927-26931 RB denotes even
T5357 26932-26935 PRP$ denotes its
T5356 26936-26949 NN denotes stoichiometry
T5358 26950-26956 IN denotes within
T5359 26957-26962 NN denotes TFIIH
T5360 26962-26964 , denotes ,
T5331 26964-26971 VBZ denotes remains
T5361 26972-26979 JJ denotes unknown
T5362 26979-26980 . denotes .
T5363 26980-27249 sentence denotes However, based on the ability of cell extracts that are defective in two different TFIIH components (XPD and XPB) to complement NER activity in vitro [26], it is likely that TFIIH (or its components) can either multimerise or exchange at least during the NER reaction.
T5364 26981-26988 RB denotes However
T5366 26988-26990 , denotes ,
T5367 26990-26995 VBN denotes based
T5368 26996-26998 IN denotes on
T5369 26999-27002 DT denotes the
T5370 27003-27010 NN denotes ability
T5371 27011-27013 IN denotes of
T5372 27014-27018 NN denotes cell
T5373 27019-27027 NNS denotes extracts
T5374 27028-27032 WDT denotes that
T5375 27033-27036 VBP denotes are
T5376 27037-27046 JJ denotes defective
T5377 27047-27049 IN denotes in
T5378 27050-27053 CD denotes two
T5380 27054-27063 JJ denotes different
T5381 27064-27069 NN denotes TFIIH
T5379 27070-27080 NNS denotes components
T5382 27081-27082 -LRB- denotes (
T5383 27082-27085 NN denotes XPD
T5384 27086-27089 CC denotes and
T5385 27090-27093 NN denotes XPB
T5386 27093-27094 -RRB- denotes )
T5387 27095-27097 TO denotes to
T5388 27098-27108 VB denotes complement
T5389 27109-27112 NN denotes NER
T5390 27113-27121 NN denotes activity
T5391 27122-27124 FW denotes in
T5392 27125-27130 FW denotes vitro
T5393 27131-27132 -LRB- denotes [
T5394 27132-27134 CD denotes 26
T5395 27134-27135 -RRB- denotes ]
T5396 27135-27137 , denotes ,
T5397 27137-27139 PRP denotes it
T5365 27140-27142 VBZ denotes is
T5398 27143-27149 JJ denotes likely
T5399 27150-27154 IN denotes that
T5401 27155-27160 NN denotes TFIIH
T5402 27161-27162 -LRB- denotes (
T5403 27162-27164 CC denotes or
T5404 27165-27168 PRP$ denotes its
T5405 27169-27179 NNS denotes components
T5406 27179-27180 -RRB- denotes )
T5407 27181-27184 MD denotes can
T5408 27185-27191 CC denotes either
T5400 27192-27203 VB denotes multimerise
T5409 27204-27206 CC denotes or
T5410 27207-27215 VB denotes exchange
T5411 27216-27218 RB denotes at
T5412 27219-27224 RBS denotes least
T5413 27225-27231 IN denotes during
T5414 27232-27235 DT denotes the
T5416 27236-27239 NN denotes NER
T5415 27240-27248 NN denotes reaction
T5417 27248-27249 . denotes .
T5418 27249-27322 sentence denotes Furthermore, XPD is known to be a “loosely bound” subunit of TFIIH [27].
T5419 27250-27261 RB denotes Furthermore
T5421 27261-27263 , denotes ,
T5422 27263-27266 NN denotes XPD
T5423 27267-27269 VBZ denotes is
T5420 27270-27275 VBN denotes known
T5424 27276-27278 TO denotes to
T5425 27279-27281 VB denotes be
T5426 27282-27283 DT denotes a
T5428 27284-27285 RB denotes “
T5429 27285-27292 RB denotes loosely
T5430 27293-27298 VBN denotes bound
T5431 27298-27299 '' denotes ”
T5427 27300-27307 NN denotes subunit
T5432 27308-27310 IN denotes of
T5433 27311-27316 NN denotes TFIIH
T5434 27317-27318 -LRB- denotes [
T5435 27318-27320 CD denotes 27
T5436 27320-27321 -RRB- denotes ]
T5437 27321-27322 . denotes .
T5438 27322-27679 sentence denotes We thus envisage the molecular mechanism of interallelic complementation to involve the exchange of XPD molecules within the TFIIH complex or turnover of TFIIH complexes containing different XPD molecules at the site of DNA damage during the course of the global genome as well as transcription-coupled repair of either UV-induced or endogenous DNA damage.
T5439 27323-27325 PRP denotes We
T5441 27326-27330 RB denotes thus
T5440 27331-27339 VBP denotes envisage
T5442 27340-27343 DT denotes the
T5444 27344-27353 JJ denotes molecular
T5443 27354-27363 NN denotes mechanism
T5446 27364-27366 IN denotes of
T5447 27367-27379 JJ denotes interallelic
T5448 27380-27395 NN denotes complementation
T5449 27396-27398 TO denotes to
T5445 27399-27406 VB denotes involve
T5450 27407-27410 DT denotes the
T5451 27411-27419 NN denotes exchange
T5452 27420-27422 IN denotes of
T5453 27423-27426 NN denotes XPD
T5454 27427-27436 NNS denotes molecules
T5455 27437-27443 IN denotes within
T5456 27444-27447 DT denotes the
T5458 27448-27453 NN denotes TFIIH
T5457 27454-27461 NN denotes complex
T5459 27462-27464 CC denotes or
T5460 27465-27473 NN denotes turnover
T5461 27474-27476 IN denotes of
T5462 27477-27482 NN denotes TFIIH
T5463 27483-27492 NNS denotes complexes
T5464 27493-27503 VBG denotes containing
T5465 27504-27513 JJ denotes different
T5467 27514-27517 NN denotes XPD
T5466 27518-27527 NNS denotes molecules
T5468 27528-27530 IN denotes at
T5469 27531-27534 DT denotes the
T5470 27535-27539 NN denotes site
T5471 27540-27542 IN denotes of
T5472 27543-27546 NN denotes DNA
T5473 27547-27553 NN denotes damage
T5474 27554-27560 IN denotes during
T5475 27561-27564 DT denotes the
T5476 27565-27571 NN denotes course
T5477 27572-27574 IN denotes of
T5478 27575-27578 DT denotes the
T5480 27579-27585 JJ denotes global
T5479 27586-27592 NN denotes genome
T5481 27593-27595 RB denotes as
T5483 27596-27600 RB denotes well
T5482 27601-27603 IN denotes as
T5484 27604-27617 NN denotes transcription
T5486 27617-27618 HYPH denotes -
T5485 27618-27625 VBN denotes coupled
T5487 27626-27632 NN denotes repair
T5488 27633-27635 IN denotes of
T5489 27636-27642 CC denotes either
T5491 27643-27645 NN denotes UV
T5493 27645-27646 HYPH denotes -
T5492 27646-27653 VBN denotes induced
T5494 27654-27656 CC denotes or
T5495 27657-27667 JJ denotes endogenous
T5496 27668-27671 NN denotes DNA
T5490 27672-27678 NN denotes damage
T5497 27678-27679 . denotes .
T5607 27681-27682 DT denotes A
T5609 27683-27692 JJ denotes Biallelic
T5608 27693-27701 NN denotes Paradigm
T5610 27702-27705 IN denotes for
T5611 27706-27709 NN denotes XPD
T5612 27710-27719 NNS denotes Disorders
T5613 27719-28001 sentence denotes Recently, proteins originating from presumed null alleles were biochemically characterised as inactive in basal transcription [27], providing an explanation as to why these alleles failed to rescue lethality in haploid S. pombe with a null mutation in the XPD homologue rad15 [19].
T5614 27720-27728 RB denotes Recently
T5616 27728-27730 , denotes ,
T5617 27730-27738 NN denotes proteins
T5618 27739-27750 VBG denotes originating
T5619 27751-27755 IN denotes from
T5620 27756-27764 VBN denotes presumed
T5622 27765-27769 JJ denotes null
T5621 27770-27777 NNS denotes alleles
T5623 27778-27782 VBD denotes were
T5624 27783-27796 RB denotes biochemically
T5615 27797-27810 VBN denotes characterised
T5625 27811-27813 IN denotes as
T5626 27814-27822 JJ denotes inactive
T5627 27823-27825 IN denotes in
T5628 27826-27831 JJ denotes basal
T5629 27832-27845 NN denotes transcription
T5630 27846-27847 -LRB- denotes [
T5631 27847-27849 CD denotes 27
T5632 27849-27850 -RRB- denotes ]
T5633 27850-27852 , denotes ,
T5634 27852-27861 VBG denotes providing
T5635 27862-27864 DT denotes an
T5636 27865-27876 NN denotes explanation
T5637 27877-27879 IN denotes as
T5638 27880-27882 IN denotes to
T5639 27883-27886 WRB denotes why
T5641 27887-27892 DT denotes these
T5642 27893-27900 NNS denotes alleles
T5640 27901-27907 VBD denotes failed
T5643 27908-27910 TO denotes to
T5644 27911-27917 VB denotes rescue
T5645 27918-27927 NN denotes lethality
T5646 27928-27930 IN denotes in
T5647 27931-27938 JJ denotes haploid
T5649 27939-27941 FW denotes S.
T5648 27942-27947 FW denotes pombe
T5650 27948-27952 IN denotes with
T5651 27953-27954 DT denotes a
T5653 27955-27959 JJ denotes null
T5652 27960-27968 NN denotes mutation
T5654 27969-27971 IN denotes in
T5655 27972-27975 DT denotes the
T5657 27976-27979 NN denotes XPD
T5656 27980-27989 NN denotes homologue
T5658 27990-27995 NN denotes rad15
T5659 27996-27997 -LRB- denotes [
T5660 27997-27999 CD denotes 19
T5661 27999-28000 -RRB- denotes ]
T5662 28000-28001 . denotes .
T5663 28001-28233 sentence denotes Our data suggest that certain presumed null alleles, although unable on their own to support basal transcription, may in fact have a substantial impact on disease outcome in compound heterozygous humans, as they do in mouse models.
T5664 28002-28005 PRP$ denotes Our
T5665 28006-28010 NNS denotes data
T5666 28011-28018 VBP denotes suggest
T5667 28019-28023 IN denotes that
T5669 28024-28031 JJ denotes certain
T5671 28032-28040 VBN denotes presumed
T5672 28041-28045 JJ denotes null
T5670 28046-28053 NNS denotes alleles
T5673 28053-28055 , denotes ,
T5674 28055-28063 IN denotes although
T5675 28064-28070 JJ denotes unable
T5676 28071-28073 IN denotes on
T5678 28074-28079 PRP$ denotes their
T5679 28080-28083 NN denotes own
T5680 28084-28086 TO denotes to
T5677 28087-28094 VB denotes support
T5681 28095-28100 JJ denotes basal
T5682 28101-28114 NN denotes transcription
T5683 28114-28116 , denotes ,
T5684 28116-28119 MD denotes may
T5685 28120-28122 IN denotes in
T5686 28123-28127 NN denotes fact
T5668 28128-28132 VB denotes have
T5687 28133-28134 DT denotes a
T5689 28135-28146 JJ denotes substantial
T5688 28147-28153 NN denotes impact
T5690 28154-28156 IN denotes on
T5691 28157-28164 NN denotes disease
T5692 28165-28172 NN denotes outcome
T5693 28173-28175 IN denotes in
T5694 28176-28184 NN denotes compound
T5696 28185-28197 JJ denotes heterozygous
T5695 28198-28204 NNS denotes humans
T5697 28204-28206 , denotes ,
T5698 28206-28208 IN denotes as
T5700 28209-28213 PRP denotes they
T5701 28214-28216 VBP denotes do
T5699 28217-28219 IN denotes in
T5702 28220-28225 NN denotes mouse
T5703 28226-28232 NNS denotes models
T5704 28232-28233 . denotes .
T5705 28233-28442 sentence denotes Clinical evidence in support of this hypothesis comes from a number of XP complementation group D patients that do not fit within the framework of the current monoallelic paradigm of XPD disorders (Figure 5).
T5706 28234-28242 JJ denotes Clinical
T5707 28243-28251 NN denotes evidence
T5709 28252-28254 IN denotes in
T5710 28255-28262 NN denotes support
T5711 28263-28265 IN denotes of
T5712 28266-28270 DT denotes this
T5713 28271-28281 NN denotes hypothesis
T5708 28282-28287 VBZ denotes comes
T5714 28288-28292 IN denotes from
T5715 28293-28294 DT denotes a
T5716 28295-28301 NN denotes number
T5717 28302-28304 IN denotes of
T5718 28305-28307 NN denotes XP
T5720 28308-28323 NN denotes complementation
T5721 28324-28329 NN denotes group
T5722 28330-28331 NN denotes D
T5719 28332-28340 NNS denotes patients
T5723 28341-28345 WDT denotes that
T5725 28346-28348 VBP denotes do
T5726 28349-28352 RB denotes not
T5724 28353-28356 VB denotes fit
T5727 28357-28363 IN denotes within
T5728 28364-28367 DT denotes the
T5729 28368-28377 NN denotes framework
T5730 28378-28380 IN denotes of
T5731 28381-28384 DT denotes the
T5733 28385-28392 JJ denotes current
T5734 28393-28404 JJ denotes monoallelic
T5732 28405-28413 NN denotes paradigm
T5735 28414-28416 IN denotes of
T5736 28417-28420 NN denotes XPD
T5737 28421-28430 NNS denotes disorders
T5738 28431-28432 -LRB- denotes (
T5739 28432-28438 NN denotes Figure
T5740 28439-28440 CD denotes 5
T5741 28440-28441 -RRB- denotes )
T5742 28441-28442 . denotes .
T5743 28442-28870 sentence denotes In contrast to two hemizygous XPDXPCS patients carrying the XPDG47R- or XPDR666W-encoding alleles who died of the disease before 2 y of age, two compound heterozygous XPDXPCS patients carrying the same XPDG47R- or XPDR666W-encoding alleles in addition to the presumed null XPDL461V+del716−730 both had considerably milder disease symptoms and survived more than ten times longer (A. Lehmann, personal communication) (Figure 5).
T5744 28443-28445 IN denotes In
T5746 28446-28454 NN denotes contrast
T5747 28455-28457 IN denotes to
T5748 28458-28461 CD denotes two
T5750 28462-28472 JJ denotes hemizygous
T5751 28473-28480 NN denotes XPDXPCS
T5749 28481-28489 NNS denotes patients
T5752 28490-28498 VBG denotes carrying
T5753 28499-28502 DT denotes the
T5755 28503-28510 NN denotes XPDG47R
T5757 28510-28511 HYPH denotes -
T5758 28512-28514 CC denotes or
T5759 28515-28523 NN denotes XPDR666W
T5760 28523-28524 HYPH denotes -
T5756 28524-28532 VBG denotes encoding
T5754 28533-28540 NNS denotes alleles
T5761 28541-28544 WP denotes who
T5762 28545-28549 VBD denotes died
T5763 28550-28552 IN denotes of
T5764 28553-28556 DT denotes the
T5765 28557-28564 NN denotes disease
T5766 28565-28571 IN denotes before
T5767 28572-28573 CD denotes 2
T5768 28574-28575 NNS denotes y
T5769 28576-28578 IN denotes of
T5770 28579-28582 NN denotes age
T5771 28582-28584 , denotes ,
T5772 28584-28587 CD denotes two
T5774 28588-28596 JJ denotes compound
T5775 28597-28609 JJ denotes heterozygous
T5776 28610-28617 NN denotes XPDXPCS
T5773 28618-28626 NNS denotes patients
T5777 28627-28635 VBG denotes carrying
T5778 28636-28639 DT denotes the
T5780 28640-28644 JJ denotes same
T5781 28645-28652 NN denotes XPDG47R
T5783 28652-28653 HYPH denotes -
T5784 28654-28656 CC denotes or
T5785 28657-28665 NN denotes XPDR666W
T5786 28665-28666 HYPH denotes -
T5782 28666-28674 VBG denotes encoding
T5779 28675-28682 NNS denotes alleles
T5787 28683-28685 IN denotes in
T5788 28686-28694 NN denotes addition
T5789 28695-28697 IN denotes to
T5790 28698-28701 DT denotes the
T5792 28702-28710 VBN denotes presumed
T5793 28711-28715 JJ denotes null
T5794 28716-28724 NN denotes XPDL461V
T5795 28724-28725 SYM denotes +
T5796 28725-28731 NN denotes del716
T5797 28731-28732 HYPH denotes −
T5791 28732-28735 NN denotes 730
T5798 28736-28740 DT denotes both
T5745 28741-28744 VBD denotes had
T5799 28745-28757 RB denotes considerably
T5800 28758-28764 JJR denotes milder
T5802 28765-28772 NN denotes disease
T5801 28773-28781 NNS denotes symptoms
T5803 28782-28785 CC denotes and
T5804 28786-28794 VBD denotes survived
T5805 28795-28799 JJR denotes more
T5807 28800-28804 IN denotes than
T5806 28805-28808 CD denotes ten
T5808 28809-28814 NNS denotes times
T5809 28815-28821 RBR denotes longer
T5810 28822-28823 -LRB- denotes (
T5811 28823-28825 NNP denotes A.
T5812 28826-28833 NNP denotes Lehmann
T5813 28833-28835 , denotes ,
T5814 28835-28843 JJ denotes personal
T5815 28844-28857 NN denotes communication
T5816 28857-28858 -RRB- denotes )
T5817 28859-28860 -LRB- denotes (
T5818 28860-28866 NN denotes Figure
T5819 28867-28868 CD denotes 5
T5820 28868-28869 -RRB- denotes )
T5821 28869-28870 . denotes .
T5822 28870-28985 sentence denotes Compound heterozygosity is also associated with the recently reported combination XP and TTD (XPTTD) syndrome [8].
T5823 28871-28879 NN denotes Compound
T5824 28880-28894 NN denotes heterozygosity
T5826 28895-28897 VBZ denotes is
T5827 28898-28902 RB denotes also
T5825 28903-28913 VBN denotes associated
T5828 28914-28918 IN denotes with
T5829 28919-28922 DT denotes the
T5831 28923-28931 RB denotes recently
T5832 28932-28940 VBN denotes reported
T5833 28941-28952 NN denotes combination
T5834 28953-28955 NN denotes XP
T5835 28956-28959 CC denotes and
T5836 28960-28963 NN denotes TTD
T5837 28964-28965 -LRB- denotes (
T5838 28965-28970 NN denotes XPTTD
T5839 28970-28971 -RRB- denotes )
T5830 28972-28980 NN denotes syndrome
T5840 28981-28982 -LRB- denotes [
T5841 28982-28983 CD denotes 8
T5842 28983-28984 -RRB- denotes ]
T5843 28984-28985 . denotes .
T5844 28985-29130 sentence denotes Similar to the XpdTTD/†XPCS and XpdTTD/†XP mice described here, both patients with XPTTD described so far had intermediate hair cysteine values.
T5845 28986-28993 JJ denotes Similar
T5847 28994-28996 IN denotes to
T5848 28997-29000 DT denotes the
T5850 29001-29007 NN denotes XpdTTD
T5852 29007-29008 HYPH denotes /
T5851 29008-29013 NN denotes †XPCS
T5853 29014-29017 CC denotes and
T5854 29018-29024 NN denotes XpdTTD
T5856 29024-29025 HYPH denotes /
T5855 29025-29028 NN denotes †XP
T5849 29029-29033 NNS denotes mice
T5857 29034-29043 VBN denotes described
T5858 29044-29048 RB denotes here
T5859 29048-29050 , denotes ,
T5860 29050-29054 DT denotes both
T5861 29055-29063 NNS denotes patients
T5862 29064-29068 IN denotes with
T5863 29069-29074 NN denotes XPTTD
T5864 29075-29084 VBN denotes described
T5865 29085-29087 RB denotes so
T5866 29088-29091 RB denotes far
T5846 29092-29095 VBD denotes had
T5867 29096-29108 JJ denotes intermediate
T5869 29109-29113 NN denotes hair
T5870 29114-29122 NN denotes cysteine
T5868 29123-29129 NNS denotes values
T5871 29129-29130 . denotes .
T5872 29130-29272 sentence denotes Furthermore, XPTTD patient XP38BR carried a “causative” TTD mutation in one allele and a novel point mutation encoding XPDL485P in the other.
T5873 29131-29142 RB denotes Furthermore
T5875 29142-29144 , denotes ,
T5876 29144-29149 NN denotes XPTTD
T5878 29150-29157 NN denotes patient
T5877 29158-29164 NN denotes XP38BR
T5874 29165-29172 VBD denotes carried
T5879 29173-29174 DT denotes a
T5881 29175-29176 `` denotes “
T5882 29176-29185 JJ denotes causative
T5883 29185-29186 '' denotes ”
T5884 29187-29190 NN denotes TTD
T5880 29191-29199 NN denotes mutation
T5885 29200-29202 IN denotes in
T5886 29203-29206 CD denotes one
T5887 29207-29213 NN denotes allele
T5888 29214-29217 CC denotes and
T5889 29218-29219 DT denotes a
T5891 29220-29225 JJ denotes novel
T5892 29226-29231 NN denotes point
T5890 29232-29240 NN denotes mutation
T5893 29241-29249 VBG denotes encoding
T5894 29250-29258 NN denotes XPDL485P
T5895 29259-29261 IN denotes in
T5896 29262-29265 DT denotes the
T5897 29266-29271 JJ denotes other
T5898 29271-29272 . denotes .
T5899 29272-29560 sentence denotes Although the XPDL485P-encoding allele fails to complement viability in the haploid S. pombe rad15 deletion strain and is thus interpretable as a null allele [8], we nonetheless suggest that the combined XPTTD phenotype in this patient involves phenotypic contributions from both alleles.
T5900 29273-29281 IN denotes Although
T5902 29282-29285 DT denotes the
T5904 29286-29294 NN denotes XPDL485P
T5906 29294-29295 HYPH denotes -
T5905 29295-29303 VBG denotes encoding
T5903 29304-29310 NN denotes allele
T5901 29311-29316 VBZ denotes fails
T5908 29317-29319 TO denotes to
T5909 29320-29330 VB denotes complement
T5910 29331-29340 NN denotes viability
T5911 29341-29343 IN denotes in
T5912 29344-29347 DT denotes the
T5914 29348-29355 JJ denotes haploid
T5915 29356-29358 FW denotes S.
T5916 29359-29364 FW denotes pombe
T5917 29365-29370 NN denotes rad15
T5918 29371-29379 NN denotes deletion
T5913 29380-29386 NN denotes strain
T5919 29387-29390 CC denotes and
T5920 29391-29393 VBZ denotes is
T5921 29394-29398 RB denotes thus
T5922 29399-29412 JJ denotes interpretable
T5923 29413-29415 IN denotes as
T5924 29416-29417 DT denotes a
T5926 29418-29422 JJ denotes null
T5925 29423-29429 NN denotes allele
T5927 29430-29431 -LRB- denotes [
T5928 29431-29432 CD denotes 8
T5929 29432-29433 -RRB- denotes ]
T5930 29433-29435 , denotes ,
T5931 29435-29437 PRP denotes we
T5932 29438-29449 RB denotes nonetheless
T5907 29450-29457 VBP denotes suggest
T5933 29458-29462 IN denotes that
T5935 29463-29466 DT denotes the
T5937 29467-29475 JJ denotes combined
T5938 29476-29481 NN denotes XPTTD
T5936 29482-29491 NN denotes phenotype
T5939 29492-29494 IN denotes in
T5940 29495-29499 DT denotes this
T5941 29500-29507 NN denotes patient
T5934 29508-29516 VBZ denotes involves
T5942 29517-29527 JJ denotes phenotypic
T5943 29528-29541 NNS denotes contributions
T5944 29542-29546 IN denotes from
T5945 29547-29551 DT denotes both
T5946 29552-29559 NNS denotes alleles
T5947 29559-29560 . denotes .
T5948 29560-29693 sentence denotes Taken together, these data suggest a shift to a biallelic paradigm for compound heterozygous patients in XP complementation group D.
T5949 29561-29566 VBN denotes Taken
T5951 29567-29575 RB denotes together
T5952 29575-29577 , denotes ,
T5953 29577-29582 DT denotes these
T5954 29583-29587 NNS denotes data
T5950 29588-29595 VBP denotes suggest
T5955 29596-29597 DT denotes a
T5956 29598-29603 NN denotes shift
T5957 29604-29606 IN denotes to
T5958 29607-29608 DT denotes a
T5960 29609-29618 JJ denotes biallelic
T5959 29619-29627 NN denotes paradigm
T5961 29628-29631 IN denotes for
T5962 29632-29640 NN denotes compound
T5964 29641-29653 JJ denotes heterozygous
T5963 29654-29662 NNS denotes patients
T5965 29663-29665 IN denotes in
T5966 29666-29668 NN denotes XP
T5968 29669-29684 NN denotes complementation
T5969 29685-29690 NN denotes group
T5967 29691-29692 NN denotes D
T5970 29692-29693 . denotes .
T9280 29704-29712 NN denotes Genotype
T9282 29712-29713 HYPH denotes –
T9281 29713-29722 NN denotes Phenotype
T9283 29723-29736 NNS denotes Relationships
T9284 29737-29739 IN denotes in
T9285 29740-29743 NN denotes XPD
T9286 29744-29753 NNS denotes Disorders
T9287 29753-29866 sentence denotes According to the current monoallelic hypothesis, phenotype is determined solely by the causative allele product.
T9288 29754-29763 VBG denotes According
T9290 29764-29766 IN denotes to
T9291 29767-29770 DT denotes the
T9293 29771-29778 JJ denotes current
T9294 29779-29790 JJ denotes monoallelic
T9292 29791-29801 NN denotes hypothesis
T9295 29801-29803 , denotes ,
T9296 29803-29812 NN denotes phenotype
T9297 29813-29815 VBZ denotes is
T9289 29816-29826 VBN denotes determined
T9298 29827-29833 RB denotes solely
T9299 29834-29836 IN denotes by
T9300 29837-29840 DT denotes the
T9302 29841-29850 JJ denotes causative
T9303 29851-29857 NN denotes allele
T9301 29858-29865 NN denotes product
T9304 29865-29866 . denotes .
T9305 29866-29944 sentence denotes If a second, different allele is present, it is considered a functional null.
T9306 29867-29869 IN denotes If
T9308 29870-29871 DT denotes a
T9310 29872-29878 JJ denotes second
T9311 29878-29880 , denotes ,
T9312 29880-29889 JJ denotes different
T9309 29890-29896 NN denotes allele
T9307 29897-29899 VBZ denotes is
T9314 29900-29907 JJ denotes present
T9315 29907-29909 , denotes ,
T9316 29909-29911 PRP denotes it
T9317 29912-29914 VBZ denotes is
T9313 29915-29925 VBN denotes considered
T9318 29926-29927 DT denotes a
T9320 29928-29938 JJ denotes functional
T9319 29939-29943 NN denotes null
T9321 29943-29944 . denotes .
T9322 29944-30044 sentence denotes There is a lack of any correlation between the site of the XPD mutation and the resulting disorder.
T9323 29945-29950 EX denotes There
T9324 29951-29953 VBZ denotes is
T9325 29954-29955 DT denotes a
T9326 29956-29960 NN denotes lack
T9327 29961-29963 IN denotes of
T9328 29964-29967 DT denotes any
T9329 29968-29979 NN denotes correlation
T9330 29980-29987 IN denotes between
T9331 29988-29991 DT denotes the
T9332 29992-29996 NN denotes site
T9333 29997-29999 IN denotes of
T9334 30000-30003 DT denotes the
T9336 30004-30007 NN denotes XPD
T9335 30008-30016 NN denotes mutation
T9337 30017-30020 CC denotes and
T9338 30021-30024 DT denotes the
T9340 30025-30034 VBG denotes resulting
T9339 30035-30043 NN denotes disorder
T9341 30043-30044 . denotes .
T9342 30044-30160 sentence denotes We propose a biallelic hypothesis for compound heterozygotes in which both alleles can contribute to the phenotype.
T9343 30045-30047 PRP denotes We
T9344 30048-30055 VBP denotes propose
T9345 30056-30057 DT denotes a
T9347 30058-30067 JJ denotes biallelic
T9346 30068-30078 NN denotes hypothesis
T9348 30079-30082 IN denotes for
T9349 30083-30091 NN denotes compound
T9350 30092-30105 NNS denotes heterozygotes
T9351 30106-30108 IN denotes in
T9353 30109-30114 WDT denotes which
T9354 30115-30119 DT denotes both
T9355 30120-30127 NNS denotes alleles
T9356 30128-30131 MD denotes can
T9352 30132-30142 VB denotes contribute
T9357 30143-30145 IN denotes to
T9358 30146-30149 DT denotes the
T9359 30150-30159 NN denotes phenotype
T9360 30159-30160 . denotes .
T9361 30160-30397 sentence denotes Examples of compound heterozygous patients in which a second, presumed null allele is likely to contribute to disease outcome are provided above in comparison to corresponding homo- or hemizygous patients with the same causative allele.
T9362 30161-30169 NNS denotes Examples
T9364 30170-30172 IN denotes of
T9365 30173-30181 NN denotes compound
T9367 30182-30194 JJ denotes heterozygous
T9366 30195-30203 NNS denotes patients
T9368 30204-30206 IN denotes in
T9370 30207-30212 WDT denotes which
T9371 30213-30214 DT denotes a
T9373 30215-30221 JJ denotes second
T9374 30221-30223 , denotes ,
T9375 30223-30231 JJ denotes presumed
T9376 30232-30236 JJ denotes null
T9372 30237-30243 NN denotes allele
T9369 30244-30246 VBZ denotes is
T9377 30247-30253 JJ denotes likely
T9378 30254-30256 TO denotes to
T9379 30257-30267 VB denotes contribute
T9380 30268-30270 IN denotes to
T9381 30271-30278 NN denotes disease
T9382 30279-30286 NN denotes outcome
T9383 30287-30290 VBP denotes are
T9363 30291-30299 VBN denotes provided
T9384 30300-30305 RB denotes above
T9385 30306-30308 IN denotes in
T9386 30309-30319 NN denotes comparison
T9387 30320-30322 IN denotes to
T9388 30323-30336 VBG denotes corresponding
T9390 30337-30341 AFX denotes homo
T9392 30341-30342 HYPH denotes -
T9393 30343-30345 CC denotes or
T9391 30346-30356 JJ denotes hemizygous
T9389 30357-30365 NNS denotes patients
T9394 30366-30370 IN denotes with
T9395 30371-30374 DT denotes the
T9397 30375-30379 JJ denotes same
T9398 30380-30389 JJ denotes causative
T9396 30390-30396 NN denotes allele
T9399 30396-30397 . denotes .
T9400 30397-30468 sentence denotes Numbers in the schematic of the protein indicate the helicase domains.
T9401 30398-30405 NNS denotes Numbers
T9403 30406-30408 IN denotes in
T9404 30409-30412 DT denotes the
T9405 30413-30422 NN denotes schematic
T9406 30423-30425 IN denotes of
T9407 30426-30429 DT denotes the
T9408 30430-30437 NN denotes protein
T9402 30438-30446 VBP denotes indicate
T9409 30447-30450 DT denotes the
T9411 30451-30459 NN denotes helicase
T9410 30460-30467 NNS denotes domains
T9412 30467-30468 . denotes .
T6041 30470-30479 NN denotes Potential
T6042 30480-30482 IN denotes of
T6043 30483-30491 VBN denotes Combined
T6045 30492-30501 JJ denotes Recessive
T6044 30502-30509 NNS denotes Alleles
T6046 30510-30512 TO denotes to
T6047 30513-30519 VB denotes Affect
T6048 30520-30530 JJ denotes Phenotypic
T6049 30531-30540 NN denotes Diversity
T6050 30541-30543 IN denotes in
T6051 30544-30551 NNS denotes Mammals
T6052 30551-30660 sentence denotes In humans, the clinical relevance of biallelic effects such as interallelic complementation remains unknown.
T6053 30552-30554 IN denotes In
T6055 30555-30561 NNS denotes humans
T6056 30561-30563 , denotes ,
T6057 30563-30566 DT denotes the
T6059 30567-30575 JJ denotes clinical
T6058 30576-30585 NN denotes relevance
T6060 30586-30588 IN denotes of
T6061 30589-30598 JJ denotes biallelic
T6062 30599-30606 NNS denotes effects
T6063 30607-30611 JJ denotes such
T6064 30612-30614 IN denotes as
T6065 30615-30627 JJ denotes interallelic
T6066 30628-30643 NN denotes complementation
T6054 30644-30651 VBZ denotes remains
T6067 30652-30659 JJ denotes unknown
T6068 30659-30660 . denotes .
T6069 30660-30904 sentence denotes Although interallelic complementation between two endogenous mutant alleles has been described in cells from a compound heterozygous patient with methylmalonic acidaemia, no observable effects on disease outcome were noted in the patient [28].
T6070 30661-30669 IN denotes Although
T6072 30670-30682 JJ denotes interallelic
T6073 30683-30698 NN denotes complementation
T6074 30699-30706 IN denotes between
T6075 30707-30710 CD denotes two
T6077 30711-30721 JJ denotes endogenous
T6078 30722-30728 JJ denotes mutant
T6076 30729-30736 NNS denotes alleles
T6079 30737-30740 VBZ denotes has
T6080 30741-30745 VBN denotes been
T6071 30746-30755 VBN denotes described
T6082 30756-30758 IN denotes in
T6083 30759-30764 NNS denotes cells
T6084 30765-30769 IN denotes from
T6085 30770-30771 DT denotes a
T6087 30772-30780 NN denotes compound
T6088 30781-30793 JJ denotes heterozygous
T6086 30794-30801 NN denotes patient
T6089 30802-30806 IN denotes with
T6090 30807-30820 JJ denotes methylmalonic
T6091 30821-30830 NN denotes acidaemia
T6092 30830-30832 , denotes ,
T6093 30832-30834 DT denotes no
T6095 30835-30845 JJ denotes observable
T6094 30846-30853 NNS denotes effects
T6096 30854-30856 IN denotes on
T6097 30857-30864 NN denotes disease
T6098 30865-30872 NN denotes outcome
T6099 30873-30877 VBD denotes were
T6081 30878-30883 VBN denotes noted
T6100 30884-30886 IN denotes in
T6101 30887-30890 DT denotes the
T6102 30891-30898 NN denotes patient
T6103 30899-30900 -LRB- denotes [
T6104 30900-30902 CD denotes 28
T6105 30902-30903 -RRB- denotes ]
T6106 30903-30904 . denotes .
T6107 30904-31122 sentence denotes Thus, to the best of our knowledge, the amelioration of progeroid features observed here is the first in vivo demonstration in compound heterozygous animals of interallelic complementation relevant to a human disease.
T6108 30905-30909 RB denotes Thus
T6110 30909-30911 , denotes ,
T6111 30911-30913 IN denotes to
T6112 30914-30917 DT denotes the
T6113 30918-30922 JJS denotes best
T6114 30923-30925 IN denotes of
T6115 30926-30929 PRP$ denotes our
T6116 30930-30939 NN denotes knowledge
T6117 30939-30941 , denotes ,
T6118 30941-30944 DT denotes the
T6119 30945-30957 NN denotes amelioration
T6120 30958-30960 IN denotes of
T6121 30961-30970 JJ denotes progeroid
T6122 30971-30979 NNS denotes features
T6123 30980-30988 VBN denotes observed
T6124 30989-30993 RB denotes here
T6109 30994-30996 VBZ denotes is
T6125 30997-31000 DT denotes the
T6127 31001-31006 JJ denotes first
T6128 31007-31009 FW denotes in
T6129 31010-31014 FW denotes vivo
T6126 31015-31028 NN denotes demonstration
T6130 31029-31031 IN denotes in
T6131 31032-31040 NN denotes compound
T6133 31041-31053 JJ denotes heterozygous
T6132 31054-31061 NNS denotes animals
T6134 31062-31064 IN denotes of
T6135 31065-31077 JJ denotes interallelic
T6136 31078-31093 NN denotes complementation
T6137 31094-31102 JJ denotes relevant
T6138 31103-31105 IN denotes to
T6139 31106-31107 DT denotes a
T6141 31108-31113 JJ denotes human
T6140 31114-31121 NN denotes disease
T6142 31121-31122 . denotes .
T6143 31122-31498 sentence denotes Keeping in mind that the ~1,200 alleles known to exist for the CTRF gene implicated in the common autosomal recessive disorder cystic fibrosis alone [29] can theoretically result in ~700,000 different allelic combinations, the potential number of allelic combinations of different recessive mutations and single nucleotide polymorphisms genome-wide is currently incalculable.
T6144 31123-31130 VBG denotes Keeping
T6146 31131-31133 IN denotes in
T6147 31134-31138 NN denotes mind
T6148 31139-31143 IN denotes that
T6150 31144-31147 DT denotes the
T6152 31148-31149 SYM denotes ~
T6153 31149-31154 CD denotes 1,200
T6151 31155-31162 NNS denotes alleles
T6154 31163-31168 VBN denotes known
T6155 31169-31171 TO denotes to
T6156 31172-31177 VB denotes exist
T6157 31178-31181 IN denotes for
T6158 31182-31185 DT denotes the
T6160 31186-31190 NN denotes CTRF
T6159 31191-31195 NN denotes gene
T6161 31196-31206 VBN denotes implicated
T6162 31207-31209 IN denotes in
T6163 31210-31213 DT denotes the
T6165 31214-31220 JJ denotes common
T6166 31221-31230 JJ denotes autosomal
T6167 31231-31240 JJ denotes recessive
T6164 31241-31249 NN denotes disorder
T6168 31250-31256 JJ denotes cystic
T6169 31257-31265 NN denotes fibrosis
T6170 31266-31271 RB denotes alone
T6171 31272-31273 -LRB- denotes [
T6172 31273-31275 CD denotes 29
T6173 31275-31276 -RRB- denotes ]
T6174 31277-31280 MD denotes can
T6175 31281-31294 RB denotes theoretically
T6149 31295-31301 VB denotes result
T6176 31302-31304 IN denotes in
T6177 31305-31306 SYM denotes ~
T6178 31306-31313 CD denotes 700,000
T6180 31314-31323 JJ denotes different
T6181 31324-31331 JJ denotes allelic
T6179 31332-31344 NNS denotes combinations
T6182 31344-31346 , denotes ,
T6183 31346-31349 DT denotes the
T6185 31350-31359 JJ denotes potential
T6184 31360-31366 NN denotes number
T6186 31367-31369 IN denotes of
T6187 31370-31377 JJ denotes allelic
T6188 31378-31390 NNS denotes combinations
T6189 31391-31393 IN denotes of
T6190 31394-31403 JJ denotes different
T6192 31404-31413 JJ denotes recessive
T6191 31414-31423 NNS denotes mutations
T6193 31424-31427 CC denotes and
T6194 31428-31434 JJ denotes single
T6196 31435-31445 NN denotes nucleotide
T6195 31446-31459 NNS denotes polymorphisms
T6197 31460-31466 NN denotes genome
T6199 31466-31467 HYPH denotes -
T6198 31467-31471 JJ denotes wide
T6145 31472-31474 VBZ denotes is
T6200 31475-31484 RB denotes currently
T6201 31485-31497 JJ denotes incalculable
T6202 31497-31498 . denotes .
T6203 31498-31705 sentence denotes We suggest biallelic effects as a previously underestimated yet important variable in considering genotype–phenotype relationships from autosomal recessive disease to normal phenotypic diversity in mammals.
T6204 31499-31501 PRP denotes We
T6205 31502-31509 VBP denotes suggest
T6206 31510-31519 JJ denotes biallelic
T6207 31520-31527 NNS denotes effects
T6208 31528-31530 IN denotes as
T6209 31531-31532 DT denotes a
T6211 31533-31543 RB denotes previously
T6212 31544-31558 VBN denotes underestimated
T6214 31559-31562 RB denotes yet
T6213 31563-31572 JJ denotes important
T6210 31573-31581 NN denotes variable
T6215 31582-31584 IN denotes in
T6216 31585-31596 VBG denotes considering
T6217 31597-31605 NN denotes genotype
T6219 31605-31606 HYPH denotes –
T6218 31606-31615 NN denotes phenotype
T6220 31616-31629 NNS denotes relationships
T6221 31630-31634 IN denotes from
T6222 31635-31644 JJ denotes autosomal
T6224 31645-31654 JJ denotes recessive
T6223 31655-31662 NN denotes disease
T6225 31663-31665 IN denotes to
T6226 31666-31672 JJ denotes normal
T6228 31673-31683 JJ denotes phenotypic
T6227 31684-31693 NN denotes diversity
T6229 31694-31696 IN denotes in
T6230 31697-31704 NNS denotes mammals
T6231 31704-31705 . denotes .
T6232 31705-31882 sentence denotes Extension of the above concept implies that recessive mutations can enter evolutionary selection in F1 provided that the second allele carries a different recessive alteration.
T6233 31706-31715 NN denotes Extension
T6235 31716-31718 IN denotes of
T6236 31719-31722 DT denotes the
T6238 31723-31728 JJ denotes above
T6237 31729-31736 NN denotes concept
T6234 31737-31744 VBZ denotes implies
T6239 31745-31749 IN denotes that
T6241 31750-31759 JJ denotes recessive
T6242 31760-31769 NNS denotes mutations
T6243 31770-31773 MD denotes can
T6240 31774-31779 VB denotes enter
T6244 31780-31792 JJ denotes evolutionary
T6245 31793-31802 NN denotes selection
T6246 31803-31805 IN denotes in
T6247 31806-31808 NN denotes F1
T6248 31809-31817 VBN denotes provided
T6249 31818-31822 IN denotes that
T6251 31823-31826 DT denotes the
T6253 31827-31833 JJ denotes second
T6252 31834-31840 NN denotes allele
T6250 31841-31848 VBZ denotes carries
T6254 31849-31850 DT denotes a
T6256 31851-31860 JJ denotes different
T6257 31861-31870 JJ denotes recessive
T6255 31871-31881 NN denotes alteration
T6258 31881-31882 . denotes .
T6259 31882-32079 sentence denotes Finally, our data highlight the potential of clinically relevant alleles previously designated as null, with little or no detectable expression or activity, to nonetheless contribute to phenotype.
T6260 31883-31890 RB denotes Finally
T6262 31890-31892 , denotes ,
T6263 31892-31895 PRP$ denotes our
T6264 31896-31900 NNS denotes data
T6261 31901-31910 VBP denotes highlight
T6265 31911-31914 DT denotes the
T6266 31915-31924 NN denotes potential
T6267 31925-31927 IN denotes of
T6268 31928-31938 RB denotes clinically
T6269 31939-31947 JJ denotes relevant
T6270 31948-31955 NNS denotes alleles
T6271 31956-31966 RB denotes previously
T6272 31967-31977 VBN denotes designated
T6273 31978-31980 IN denotes as
T6274 31981-31985 JJ denotes null
T6275 31985-31987 , denotes ,
T6276 31987-31991 IN denotes with
T6277 31992-31998 JJ denotes little
T6279 31999-32001 CC denotes or
T6280 32002-32004 DT denotes no
T6281 32005-32015 JJ denotes detectable
T6278 32016-32026 NN denotes expression
T6282 32027-32029 CC denotes or
T6283 32030-32038 NN denotes activity
T6284 32038-32040 , denotes ,
T6285 32040-32042 TO denotes to
T6287 32043-32054 RB denotes nonetheless
T6286 32055-32065 VB denotes contribute
T6288 32066-32068 IN denotes to
T6289 32069-32078 NN denotes phenotype
T6290 32078-32079 . denotes .
T6364 32104-32114 NN denotes Derivation
T6365 32115-32118 CC denotes and
T6366 32119-32127 NN denotes analysis
T6367 32128-32130 IN denotes of
T6368 32131-32137 JJ denotes mutant
T6369 32138-32142 NNS denotes mice
T6370 32142-32143 . denotes .
T6371 32143-32233 sentence denotes Generation of XpdTTD (XPDR722W) and XpdTTD/KO mice has been described previously [21,22].
T6372 32144-32154 NN denotes Generation
T6374 32155-32157 IN denotes of
T6375 32158-32164 NN denotes XpdTTD
T6377 32165-32166 -LRB- denotes (
T6378 32166-32174 NN denotes XPDR722W
T6379 32174-32175 -RRB- denotes )
T6380 32176-32179 CC denotes and
T6381 32180-32186 NN denotes XpdTTD
T6383 32186-32187 HYPH denotes /
T6382 32187-32189 NN denotes KO
T6376 32190-32194 NNS denotes mice
T6384 32195-32198 VBZ denotes has
T6385 32199-32203 VBN denotes been
T6373 32204-32213 VBN denotes described
T6386 32214-32224 RB denotes previously
T6387 32225-32226 -LRB- denotes [
T6389 32226-32228 CD denotes 21
T6390 32228-32229 , denotes ,
T6388 32229-32231 CD denotes 22
T6391 32231-32232 -RRB- denotes ]
T6392 32232-32233 . denotes .
T6393 32233-32422 sentence denotes A detailed description of the generation of targeting constructs for Xpd†XPCS and Xpd †XP alleles carrying mutations encoding the G602D and R683W alterations will be provided upon request.
T6394 32234-32235 DT denotes A
T6396 32236-32244 JJ denotes detailed
T6395 32245-32256 NN denotes description
T6398 32257-32259 IN denotes of
T6399 32260-32263 DT denotes the
T6400 32264-32274 NN denotes generation
T6401 32275-32277 IN denotes of
T6402 32278-32287 VBG denotes targeting
T6403 32288-32298 NNS denotes constructs
T6404 32299-32302 IN denotes for
T6405 32303-32311 NN denotes Xpd†XPCS
T6407 32312-32315 CC denotes and
T6408 32316-32323 NN denotes Xpd †XP
T6406 32324-32331 NNS denotes alleles
T6409 32332-32340 VBG denotes carrying
T6410 32341-32350 NNS denotes mutations
T6411 32351-32359 VBG denotes encoding
T6412 32360-32363 DT denotes the
T6414 32364-32369 NN denotes G602D
T6415 32370-32373 CC denotes and
T6416 32374-32379 NN denotes R683W
T6413 32380-32391 NNS denotes alterations
T6417 32392-32396 MD denotes will
T6418 32397-32399 VB denotes be
T6397 32400-32408 VBN denotes provided
T6419 32409-32413 IN denotes upon
T6420 32414-32421 NN denotes request
T6421 32421-32422 . denotes .
T6422 32422-32517 sentence denotes Chimeric mice and mouse embryonic fibroblasts were generated according to standard procedures.
T6423 32423-32431 JJ denotes Chimeric
T6425 32432-32436 NNS denotes mice
T6426 32437-32440 CC denotes and
T6427 32441-32446 NN denotes mouse
T6428 32447-32456 JJ denotes embryonic
T6424 32457-32468 NNS denotes fibroblasts
T6430 32469-32473 VBD denotes were
T6429 32474-32483 VBN denotes generated
T6431 32484-32493 VBG denotes according
T6432 32494-32496 IN denotes to
T6433 32497-32505 JJ denotes standard
T6434 32506-32516 NNS denotes procedures
T6435 32516-32517 . denotes .
T6436 32517-32597 sentence denotes Haematoxylin and eosin staining was performed according to standard procedures.
T6437 32518-32530 NN denotes Haematoxylin
T6439 32531-32534 CC denotes and
T6440 32535-32540 NN denotes eosin
T6438 32541-32549 NN denotes staining
T6442 32550-32553 VBD denotes was
T6441 32554-32563 VBN denotes performed
T6443 32564-32573 VBG denotes according
T6444 32574-32576 IN denotes to
T6445 32577-32585 JJ denotes standard
T6446 32586-32596 NNS denotes procedures
T6447 32596-32597 . denotes .
T6448 32597-32653 sentence denotes Amino acid analysis was conducted as described in [21].
T6449 32598-32603 NN denotes Amino
T6450 32604-32608 NN denotes acid
T6451 32609-32617 NN denotes analysis
T6453 32618-32621 VBD denotes was
T6452 32622-32631 VBN denotes conducted
T6454 32632-32634 IN denotes as
T6455 32635-32644 VBN denotes described
T6456 32645-32647 IN denotes in
T6457 32648-32649 -LRB- denotes [
T6458 32649-32651 CD denotes 21
T6459 32651-32652 -RRB- denotes ]
T6460 32652-32653 . denotes .
T6461 32653-32750 sentence denotes Blood values were analysed using Animal Blood Counter Vet (ABX Diagnostix, Montpellier, France).
T6462 32654-32659 NN denotes Blood
T6463 32660-32666 NNS denotes values
T6465 32667-32671 VBD denotes were
T6464 32672-32680 VBN denotes analysed
T6466 32681-32686 VBG denotes using
T6467 32687-32693 NN denotes Animal
T6469 32694-32699 NN denotes Blood
T6470 32700-32707 JJ denotes Counter
T6468 32708-32711 NN denotes Vet
T6471 32712-32713 -LRB- denotes (
T6473 32713-32716 NNP denotes ABX
T6472 32717-32727 NNP denotes Diagnostix
T6474 32727-32729 , denotes ,
T6475 32729-32740 NNP denotes Montpellier
T6476 32740-32742 , denotes ,
T6477 32742-32748 NNP denotes France
T6478 32748-32749 -RRB- denotes )
T6479 32749-32750 . denotes .
T6480 32750-32845 sentence denotes Radiographs were taken, and relative bone mineral density was calculated as described in [15].
T6481 32751-32762 NNS denotes Radiographs
T6483 32763-32767 VBD denotes were
T6482 32768-32773 VBN denotes taken
T6484 32773-32775 , denotes ,
T6485 32775-32778 CC denotes and
T6486 32779-32787 JJ denotes relative
T6488 32788-32792 NN denotes bone
T6489 32793-32800 NN denotes mineral
T6487 32801-32808 NN denotes density
T6491 32809-32812 VBD denotes was
T6490 32813-32823 VBN denotes calculated
T6492 32824-32826 IN denotes as
T6493 32827-32836 VBN denotes described
T6494 32837-32839 IN denotes in
T6495 32840-32841 -LRB- denotes [
T6496 32841-32843 CD denotes 15
T6497 32843-32844 -RRB- denotes ]
T6498 32844-32845 . denotes .
T6499 32845-32936 sentence denotes Mice used in this study were in a 129Ola/C57BL6 mixed background unless noted differently.
T6500 32846-32850 NNS denotes Mice
T6502 32851-32855 VBN denotes used
T6503 32856-32858 IN denotes in
T6504 32859-32863 DT denotes this
T6505 32864-32869 NN denotes study
T6501 32870-32874 VBD denotes were
T6506 32875-32877 IN denotes in
T6507 32878-32879 DT denotes a
T6509 32880-32886 NN denotes 129Ola
T6511 32886-32887 HYPH denotes /
T6510 32887-32893 NN denotes C57BL6
T6512 32894-32899 JJ denotes mixed
T6508 32900-32910 NN denotes background
T6513 32911-32917 IN denotes unless
T6514 32918-32923 VBN denotes noted
T6515 32924-32935 RB denotes differently
T6516 32935-32936 . denotes .
T6517 32936-33163 sentence denotes All experiments involving mice were judged and approved by the national committee for genetic identification of organisms and the animal ethical committee, and were conducted according to national and international guidelines.
T6518 32937-32940 DT denotes All
T6519 32941-32952 NNS denotes experiments
T6521 32953-32962 VBG denotes involving
T6522 32963-32967 NNS denotes mice
T6523 32968-32972 VBD denotes were
T6520 32973-32979 VBN denotes judged
T6524 32980-32983 CC denotes and
T6525 32984-32992 VBN denotes approved
T6526 32993-32995 IN denotes by
T6527 32996-32999 DT denotes the
T6529 33000-33008 JJ denotes national
T6528 33009-33018 NN denotes committee
T6530 33019-33022 IN denotes for
T6531 33023-33030 JJ denotes genetic
T6532 33031-33045 NN denotes identification
T6533 33046-33048 IN denotes of
T6534 33049-33058 NNS denotes organisms
T6535 33059-33062 CC denotes and
T6536 33063-33066 DT denotes the
T6538 33067-33073 NN denotes animal
T6539 33074-33081 JJ denotes ethical
T6537 33082-33091 NN denotes committee
T6540 33091-33093 , denotes ,
T6541 33093-33096 CC denotes and
T6542 33097-33101 VBD denotes were
T6543 33102-33111 VBN denotes conducted
T6544 33112-33121 VBG denotes according
T6545 33122-33124 IN denotes to
T6546 33125-33133 JJ denotes national
T6548 33134-33137 CC denotes and
T6549 33138-33151 JJ denotes international
T6547 33152-33162 NNS denotes guidelines
T6550 33162-33163 . denotes .
T6587 33165-33167 NN denotes UV
T6588 33168-33179 NN denotes sensitivity
T6589 33179-33181 , denotes ,
T6590 33181-33183 NN denotes UV
T6592 33183-33184 HYPH denotes -
T6591 33184-33187 NN denotes UDS
T6594 33187-33189 , denotes ,
T6595 33189-33191 NN denotes UV
T6597 33191-33192 HYPH denotes -
T6596 33192-33195 NN denotes RRS
T6598 33195-33197 , denotes ,
T6599 33197-33200 CC denotes and
T6600 33201-33206 NN denotes TFIIH
T6601 33207-33215 NN denotes incision
T6603 33215-33216 HYPH denotes /
T6602 33216-33224 NN denotes excision
T6593 33225-33233 NN denotes activity
T6604 33233-33234 . denotes .
T6605 33234-33321 sentence denotes UV survival, UV-UDS, and UV-RRS assays were performed as described previously [21,30].
T6606 33235-33237 NN denotes UV
T6607 33238-33246 NN denotes survival
T6609 33246-33248 , denotes ,
T6610 33248-33250 NN denotes UV
T6612 33250-33251 HYPH denotes -
T6611 33251-33254 NN denotes UDS
T6613 33254-33256 , denotes ,
T6614 33256-33259 CC denotes and
T6615 33260-33262 NN denotes UV
T6617 33262-33263 HYPH denotes -
T6616 33263-33266 NN denotes RRS
T6608 33267-33273 NNS denotes assays
T6619 33274-33278 VBD denotes were
T6618 33279-33288 VBN denotes performed
T6620 33289-33291 IN denotes as
T6621 33292-33301 VBN denotes described
T6622 33302-33312 RB denotes previously
T6623 33313-33314 -LRB- denotes [
T6625 33314-33316 CD denotes 21
T6626 33316-33317 , denotes ,
T6624 33317-33319 CD denotes 30
T6627 33319-33320 -RRB- denotes ]
T6628 33320-33321 . denotes .
T6629 33321-33480 sentence denotes For UV-RRS, average values from the representative experiment containing two wt, three XpdTTD/TTD, two XpdTTD/XPCS, and one XpdTTD/XP cell line are presented.
T6630 33322-33325 IN denotes For
T6632 33326-33328 NN denotes UV
T6634 33328-33329 HYPH denotes -
T6633 33329-33332 NN denotes RRS
T6635 33332-33334 , denotes ,
T6636 33334-33341 JJ denotes average
T6637 33342-33348 NNS denotes values
T6638 33349-33353 IN denotes from
T6639 33354-33357 DT denotes the
T6641 33358-33372 JJ denotes representative
T6640 33373-33383 NN denotes experiment
T6642 33384-33394 VBG denotes containing
T6643 33395-33398 CD denotes two
T6644 33399-33401 NN denotes wt
T6646 33401-33403 , denotes ,
T6647 33403-33408 CD denotes three
T6649 33409-33415 NN denotes XpdTTD
T6650 33415-33416 HYPH denotes /
T6648 33416-33419 NN denotes TTD
T6651 33419-33421 , denotes ,
T6652 33421-33424 CD denotes two
T6654 33425-33431 NN denotes XpdTTD
T6655 33431-33432 HYPH denotes /
T6653 33432-33436 NN denotes XPCS
T6656 33436-33438 , denotes ,
T6657 33438-33441 CC denotes and
T6658 33442-33445 CD denotes one
T6660 33446-33452 NN denotes XpdTTD
T6661 33452-33453 HYPH denotes /
T6659 33453-33455 NN denotes XP
T6662 33456-33460 NN denotes cell
T6645 33461-33465 NN denotes line
T6663 33466-33469 VBP denotes are
T6631 33470-33479 VBN denotes presented
T6664 33479-33480 . denotes .
T6665 33480-33728 sentence denotes The ~48% UV-UDS value presented in this study for XpdTTD/TTD cells differs from our previously published data of 25% UV-UDS [21], possibly because of the high variability intrinsic to the assay or routine variations in the cell culture conditions.
T6666 33481-33484 DT denotes The
T6668 33485-33486 SYM denotes ~
T6669 33486-33488 CD denotes 48
T6670 33488-33489 NN denotes %
T6671 33490-33492 NN denotes UV
T6673 33492-33493 HYPH denotes -
T6672 33493-33496 NN denotes UDS
T6667 33497-33502 NN denotes value
T6675 33503-33512 VBN denotes presented
T6676 33513-33515 IN denotes in
T6677 33516-33520 DT denotes this
T6678 33521-33526 NN denotes study
T6679 33527-33530 IN denotes for
T6680 33531-33537 NN denotes XpdTTD
T6682 33537-33538 HYPH denotes /
T6681 33538-33541 NN denotes TTD
T6683 33542-33547 NNS denotes cells
T6674 33548-33555 VBZ denotes differs
T6684 33556-33560 IN denotes from
T6685 33561-33564 PRP$ denotes our
T6687 33565-33575 RB denotes previously
T6688 33576-33585 VBN denotes published
T6686 33586-33590 NNS denotes data
T6689 33591-33593 IN denotes of
T6690 33594-33596 CD denotes 25
T6691 33596-33597 NN denotes %
T6693 33598-33600 NN denotes UV
T6694 33600-33601 HYPH denotes -
T6692 33601-33604 NN denotes UDS
T6695 33605-33606 -LRB- denotes [
T6696 33606-33608 CD denotes 21
T6697 33608-33609 -RRB- denotes ]
T6698 33609-33611 , denotes ,
T6699 33611-33619 RB denotes possibly
T6700 33620-33627 IN denotes because
T6701 33628-33630 IN denotes of
T6702 33631-33634 DT denotes the
T6704 33635-33639 JJ denotes high
T6703 33640-33651 NN denotes variability
T6705 33652-33661 JJ denotes intrinsic
T6706 33662-33664 IN denotes to
T6707 33665-33668 DT denotes the
T6708 33669-33674 NN denotes assay
T6709 33675-33677 CC denotes or
T6710 33678-33685 JJ denotes routine
T6711 33686-33696 NNS denotes variations
T6712 33697-33699 IN denotes in
T6713 33700-33703 DT denotes the
T6715 33704-33708 NN denotes cell
T6716 33709-33716 NN denotes culture
T6714 33717-33727 NNS denotes conditions
T6717 33727-33728 . denotes .
T6718 33728-33843 sentence denotes For the incision/excision activity assay, recombinant TFIIH was prepared and assayed as described previously [27].
T6719 33729-33732 IN denotes For
T6721 33733-33736 DT denotes the
T6723 33737-33745 NN denotes incision
T6725 33745-33746 HYPH denotes /
T6724 33746-33754 NN denotes excision
T6726 33755-33763 NN denotes activity
T6722 33764-33769 NN denotes assay
T6727 33769-33771 , denotes ,
T6728 33771-33782 JJ denotes recombinant
T6729 33783-33788 NN denotes TFIIH
T6730 33789-33792 VBD denotes was
T6720 33793-33801 VBN denotes prepared
T6731 33802-33805 CC denotes and
T6732 33806-33813 VBN denotes assayed
T6733 33814-33816 IN denotes as
T6734 33817-33826 VBN denotes described
T6735 33827-33837 RB denotes previously
T6736 33838-33839 -LRB- denotes [
T6737 33839-33841 CD denotes 27
T6738 33841-33842 -RRB- denotes ]
T6739 33842-33843 . denotes .
T6770 33845-33856 JJ denotes Comparative
T6771 33857-33875 NN denotes immunofluorescence
T6772 33875-33876 . denotes .
T6773 33876-34078 sentence denotes Latex bead labelling and comparative immunofluorescence analysis of the p62 subunit of the TFIIH was performed as described previously [16,17] using primary mouse embryonic fibroblasts at passages 2–5.
T6774 33877-33882 NN denotes Latex
T6776 33883-33887 NN denotes bead
T6775 33888-33897 NN denotes labelling
T6778 33898-33901 CC denotes and
T6779 33902-33913 JJ denotes comparative
T6781 33914-33932 NN denotes immunofluorescence
T6780 33933-33941 NN denotes analysis
T6782 33942-33944 IN denotes of
T6783 33945-33948 DT denotes the
T6785 33949-33952 NN denotes p62
T6784 33953-33960 NN denotes subunit
T6786 33961-33963 IN denotes of
T6787 33964-33967 DT denotes the
T6788 33968-33973 NN denotes TFIIH
T6789 33974-33977 VBD denotes was
T6777 33978-33987 VBN denotes performed
T6790 33988-33990 IN denotes as
T6791 33991-34000 VBN denotes described
T6792 34001-34011 RB denotes previously
T6793 34012-34013 -LRB- denotes [
T6795 34013-34015 CD denotes 16
T6796 34015-34016 , denotes ,
T6794 34016-34018 CD denotes 17
T6797 34018-34019 -RRB- denotes ]
T6798 34020-34025 VBG denotes using
T6799 34026-34033 JJ denotes primary
T6801 34034-34039 NN denotes mouse
T6802 34040-34049 JJ denotes embryonic
T6800 34050-34061 NNS denotes fibroblasts
T6803 34062-34064 IN denotes at
T6804 34065-34073 NNS denotes passages
T6805 34074-34075 CD denotes 2
T6806 34075-34076 SYM denotes –
T6807 34076-34077 CD denotes 5
T6808 34077-34078 . denotes .
T6809 34078-34275 sentence denotes Two or more cell lines per genotype (except for the XpdTTD/†XP cells, in which only one cell line was used in repeated experiments) were used, and experiments were repeated 2–6 times per genotype.
T6810 34079-34082 CD denotes Two
T6812 34083-34085 CC denotes or
T6813 34086-34090 JJR denotes more
T6814 34091-34095 NN denotes cell
T6811 34096-34101 NNS denotes lines
T6816 34102-34105 IN denotes per
T6817 34106-34114 NN denotes genotype
T6818 34115-34116 -LRB- denotes (
T6819 34116-34122 IN denotes except
T6820 34123-34126 IN denotes for
T6821 34127-34130 DT denotes the
T6823 34131-34137 NN denotes XpdTTD
T6825 34137-34138 HYPH denotes /
T6824 34138-34141 NN denotes †XP
T6822 34142-34147 NNS denotes cells
T6826 34147-34149 , denotes ,
T6827 34149-34151 IN denotes in
T6829 34152-34157 WDT denotes which
T6830 34158-34162 RB denotes only
T6832 34163-34166 CD denotes one
T6833 34167-34171 NN denotes cell
T6831 34172-34176 NN denotes line
T6834 34177-34180 VBD denotes was
T6828 34181-34185 VBN denotes used
T6835 34186-34188 IN denotes in
T6836 34189-34197 VBN denotes repeated
T6837 34198-34209 NNS denotes experiments
T6838 34209-34210 -RRB- denotes )
T6839 34211-34215 VBD denotes were
T6815 34216-34220 VBN denotes used
T6840 34220-34222 , denotes ,
T6841 34222-34225 CC denotes and
T6842 34226-34237 NNS denotes experiments
T6844 34238-34242 VBD denotes were
T6843 34243-34251 VBN denotes repeated
T6845 34252-34253 CD denotes 2
T6847 34253-34254 HYPH denotes –
T6846 34254-34255 CD denotes 6
T6848 34256-34261 NNS denotes times
T6849 34262-34265 IN denotes per
T6850 34266-34274 NN denotes genotype
T6851 34274-34275 . denotes .
R1000 T1496 T1497 mark Because,was
R1001 T1497 T1500 advcl was,expected
R1002 T1498 T1499 compound patient,XPCS2
R1003 T1499 T1497 nsubj XPCS2,was
R1004 T1501 T1502 det a,hemizygote
R1005 T1502 T1497 attr hemizygote,was
R1006 T1503 T1502 prep with,hemizygote
R1007 T1504 T1505 amod mutant,protein
R1008 T1505 T1503 pobj protein,with
R1009 T1506 T1505 compound XPD,protein
R1010 T1507 T1508 punct (,XPDG602D
R1011 T1508 T1505 parataxis XPDG602D,protein
R1012 T1509 T1508 punct ),XPDG602D
R1013 T1510 T1505 acl expressed,protein
R1014 T1511 T1510 prep from,expressed
R1015 T1512 T1513 det a,allele
R1016 T1513 T1511 pobj allele,from
R1017 T1514 T1513 amod single,allele
R1018 T1515 T1500 punct ", ",expected
R1019 T1516 T1517 det the,mutation
R1020 T1517 T1500 nsubjpass mutation,expected
R1021 T1518 T1517 amod corresponding,mutation
R1022 T1519 T1500 auxpass was,expected
R1023 T1520 T1521 aux to,be
R1024 T1521 T1500 xcomp be,expected
R1025 T1522 T1521 acomp viable,be
R1026 T1523 T1521 prep in,be
R1027 T1524 T1525 det the,state
R1028 T1525 T1523 pobj state,in
R1029 T1526 T1525 amod homozygous,state
R1030 T1527 T1500 punct .,expected
R1031 T1529 T1530 advmod However,observed
R1032 T1531 T1530 punct ", ",observed
R1033 T1532 T1533 amod homozygous,mice
R1034 T1533 T1530 nsubjpass mice,observed
R1035 T1534 T1533 amod mutant,mice
R1036 T1535 T1530 auxpass were,observed
R1037 T1536 T1530 neg not,observed
R1038 T1537 T1530 punct ", ",observed
R1039 T1538 T1539 preconj neither,amongst
R1040 T1539 T1530 prep amongst,observed
R1041 T1540 T1541 amod live,births
R1042 T1541 T1539 pobj births,amongst
R1043 T1542 T1541 cc nor,births
R1044 T1543 T1544 amod embryonic,day
R1045 T1544 T1545 nmod day,embryos
R1046 T1545 T1541 conj embryos,births
R1047 T1546 T1544 nummod 13.5,day
R1048 T1547 T1544 punct (,day
R1049 T1548 T1544 appos E13.5,day
R1050 T1549 T1544 punct ),day
R1051 T1550 T1544 cc or,day
R1052 T1551 T1544 conj E3.5,day
R1053 T1552 T1553 punct (,Table
R1054 T1553 T1530 parataxis Table,observed
R1055 T1554 T1553 nummod 1,Table
R1056 T1555 T1553 punct ),Table
R1057 T1556 T1530 punct .,observed
R1058 T1558 T1559 det The,allele
R1059 T1559 T1564 nsubjpass allele,designated
R1060 T1560 T1559 amod corresponding,allele
R1061 T1561 T1559 amod hypomorphic,allele
R1062 T1562 T1559 punct ", ",allele
R1063 T1563 T1559 amod mutant,allele
R1064 T1565 T1564 auxpass was,designated
R1065 T1566 T1564 advmod thus,designated
R1066 T1567 T1564 prep as,designated
R1067 T1568 T1569 amod homozygous,lethal
R1068 T1569 T1567 pobj lethal,as
R1069 T1570 T1571 punct (,†XPCS
R1070 T1571 T1569 parataxis †XPCS,lethal
R1071 T1572 T1571 punct ),†XPCS
R1072 T1573 T1564 punct .,designated
R1073 T1575 T1576 amod Homozygous,lethality
R1074 T1576 T1577 nsubj lethality,is
R1075 T1578 T1576 prep of,lethality
R1076 T1579 T1580 det the,allele
R1077 T1580 T1578 pobj allele,of
R1078 T1581 T1580 compound XPCS,allele
R1079 T1582 T1583 advmod likely,due
R1080 T1583 T1577 prep due,is
R1081 T1584 T1583 prep to,due
R1082 T1585 T1586 amod reduced,levels
R1083 T1586 T1584 pobj levels,to
R1084 T1587 T1586 prep of,levels
R1085 T1588 T1587 pobj expression,of
R1086 T1589 T1588 prep of,expression
R1087 T1590 T1591 det this,protein
R1088 T1591 T1589 pobj protein,of
R1089 T1592 T1591 amod essential,protein
R1090 T1593 T1586 prep as,levels
R1091 T1594 T1595 det a,result
R1092 T1595 T1593 pobj result,as
R1093 T1596 T1595 prep of,result
R1094 T1597 T1598 compound gene,targeting
R1095 T1598 T1596 pobj targeting,of
R1096 T1599 T1600 punct (,1A
R1097 T1600 T1598 parataxis 1A,targeting
R1098 T1601 T1600 compound Figure,1A
R1099 T1602 T1600 punct ),1A
R1100 T1603 T1604 amod rather,than
R1101 T1604 T1584 cc than,to
R1102 T1605 T1584 conj to,to
R1103 T1606 T1607 det the,mutation
R1104 T1607 T1605 pobj mutation,to
R1105 T1608 T1607 appos itself,mutation
R1106 T1609 T1577 punct .,is
R1107 T1611 T1612 compound Xpd,ablation
R1108 T1612 T1613 nsubj ablation,is
R1109 T1614 T1615 punct (,KO
R1110 T1615 T1612 parataxis KO,ablation
R1111 T1616 T1615 compound XpdKO,KO
R1112 T1617 T1615 punct /,KO
R1113 T1618 T1615 punct ),KO
R1114 T1619 T1620 advmod similarly,incompatible
R1115 T1620 T1613 acomp incompatible,is
R1116 T1621 T1620 prep with,incompatible
R1117 T1622 T1621 pobj life,with
R1118 T1623 T1622 prep beyond,life
R1119 T1624 T1625 det the,stages
R1120 T1625 T1623 pobj stages,beyond
R1121 T1626 T1625 amod earliest,stages
R1122 T1627 T1625 prep of,stages
R1123 T1628 T1627 pobj embryogenesis,of
R1124 T1629 T1630 punct [,22
R1125 T1630 T1613 parataxis 22,is
R1126 T1631 T1630 punct ],22
R1127 T1632 T1613 punct .,is
R1128 T1634 T1635 advcl Consistent,was
R1129 T1636 T1634 prep with,Consistent
R1130 T1637 T1638 det this,interpretation
R1131 T1638 T1636 pobj interpretation,with
R1132 T1639 T1635 punct ", ",was
R1133 T1640 T1641 det a,mutation
R1134 T1641 T1635 nsubj mutation,was
R1135 T1642 T1641 amod different,mutation
R1136 T1643 T1641 amod targeted,mutation
R1137 T1644 T1641 compound Xpd,mutation
R1138 T1645 T1641 acl encoding,mutation
R1139 T1646 T1645 dobj XPDR683W,encoding
R1140 T1647 T1646 punct ", ",XPDR683W
R1141 T1648 T1649 dep which,associated
R1142 T1649 T1646 relcl associated,XPDR683W
R1143 T1650 T1649 auxpass is,associated
R1144 T1651 T1649 prep with,associated
R1145 T1652 T1651 pobj XP,with
R1146 T1653 T1649 prep in,associated
R1147 T1654 T1655 det the,state
R1148 T1655 T1653 pobj state,in
R1149 T1656 T1655 amod homozygous,state
R1150 T1657 T1649 prep in,associated
R1151 T1658 T1657 pobj humans,in
R1152 T1659 T1635 punct ", ",was
R1153 T1660 T1661 advmod similarly,underexpressed
R1154 T1661 T1635 acomp underexpressed,was
R1155 T1662 T1661 cc and,underexpressed
R1156 T1663 T1661 conj lethal,underexpressed
R1157 T1664 T1635 prep in,was
R1158 T1665 T1666 det the,state
R1159 T1666 T1664 pobj state,in
R1160 T1667 T1666 amod homozygous,state
R1161 T1668 T1669 punct (,designated
R1162 T1669 T1635 parataxis designated,was
R1163 T1670 T1669 prep as,designated
R1164 T1671 T1672 compound †XP,allele
R1165 T1672 T1670 pobj allele,as
R1166 T1673 T1669 punct ),designated
R1167 T1674 T1675 punct (,1A
R1168 T1675 T1635 parataxis 1A,was
R1169 T1676 T1675 compound Figure,1A
R1170 T1677 T1678 punct –,1C
R1171 T1678 T1675 prep 1C,1A
R1172 T1679 T1675 punct ;,1A
R1173 T1680 T1675 appos Table,1A
R1174 T1681 T1680 nummod 1,Table
R1175 T1682 T1675 punct ;,1A
R1176 T1683 T1684 amod unpublished,data
R1177 T1684 T1675 appos data,1A
R1178 T1685 T1675 punct ),1A
R1179 T1686 T1635 punct .,was
R1180 T1688 T1689 advmod Also,resulted
R1181 T1690 T1689 punct ", ",resulted
R1182 T1691 T1692 det a,approach
R1183 T1692 T1689 nsubj approach,resulted
R1184 T1693 T1692 amod different,approach
R1185 T1694 T1692 compound targeting,approach
R1186 T1695 T1692 acl leading,approach
R1187 T1696 T1695 prep to,leading
R1188 T1697 T1698 det the,use
R1189 T1698 T1696 pobj use,to
R1190 T1699 T1698 prep of,use
R1191 T1700 T1701 det the,UTR
R1192 T1701 T1699 pobj UTR,of
R1193 T1702 T1701 amod native,UTR
R1194 T1703 T1701 nummod 3,UTR
R1195 T1704 T1703 punct ′,3
R1196 T1705 T1698 cc and,use
R1197 T1706 T1698 conj removal,use
R1198 T1707 T1706 prep of,removal
R1199 T1708 T1709 det the,gene
R1200 T1709 T1707 pobj gene,of
R1201 T1710 T1709 compound neo,gene
R1202 T1711 T1689 prep in,resulted
R1203 T1712 T1711 pobj normalisation,in
R1204 T1713 T1712 prep of,normalisation
R1205 T1714 T1715 compound XpdXPCS,levels
R1206 T1715 T1713 pobj levels,of
R1207 T1716 T1715 compound mRNA,levels
R1208 T1717 T1712 cc and,normalisation
R1209 T1718 T1719 amod viable,animals
R1210 T1719 T1712 conj animals,normalisation
R1211 T1720 T1719 amod homozygous,animals
R1212 T1721 T1722 nmod XpdXPCS,XPCS
R1213 T1722 T1719 nmod XPCS,animals
R1214 T1723 T1722 punct /,XPCS
R1215 T1724 T1725 punct (,G602D
R1216 T1725 T1722 parataxis G602D,XPCS
R1217 T1726 T1725 compound XPDG602D,G602D
R1218 T1727 T1725 punct /,G602D
R1219 T1728 T1725 punct ),G602D
R1220 T1729 T1730 punct [,23
R1221 T1730 T1689 parataxis 23,resulted
R1222 T1731 T1730 punct ],23
R1223 T1732 T1689 punct .,resulted
R1226 T1954 T1955 punct “,Allele
R1227 T1955 T1958 nsubj Allele,Alleviate
R1228 T1956 T1955 amod Null,Allele
R1229 T1957 T1955 punct ”,Allele
R1230 T1959 T1958 aux Can,Alleviate
R1231 T1960 T1961 amod Developmental,Delay
R1232 T1961 T1958 dobj Delay,Alleviate
R1233 T1962 T1961 punct ", ",Delay
R1234 T1963 T1964 nmod Skin,Features
R1235 T1964 T1961 appos Features,Delay
R1236 T1965 T1963 punct ", ",Skin
R1237 T1966 T1963 cc and,Skin
R1238 T1967 T1963 conj Hair,Skin
R1239 T1968 T1964 prep of,Features
R1240 T1969 T1968 pobj TTD,of
R1241 T1971 T1972 aux To,test
R1242 T1972 T1973 advcl test,combined
R1243 T1974 T1975 det the,potential
R1244 T1975 T1972 dobj potential,test
R1245 T1976 T1975 prep of,potential
R1246 T1977 T1978 det a,allele
R1247 T1978 T1976 pobj allele,of
R1248 T1979 T1978 amod homozygous,allele
R1249 T1980 T1978 amod lethal,allele
R1250 T1981 T1978 punct “,allele
R1251 T1982 T1978 amod null,allele
R1252 T1983 T1978 punct ”,allele
R1253 T1984 T1985 aux to,contribute
R1254 T1985 T1975 acl contribute,potential
R1255 T1986 T1985 advmod nevertheless,contribute
R1256 T1987 T1985 prep to,contribute
R1257 T1988 T1989 amod organismal,phenotype
R1258 T1989 T1987 pobj phenotype,to
R1259 T1990 T1973 punct ", ",combined
R1260 T1991 T1973 nsubj we,combined
R1261 T1992 T1993 det an,allele
R1262 T1993 T1973 dobj allele,combined
R1263 T1994 T1993 compound Xpd†XPCS,allele
R1264 T1995 T1993 prep with,allele
R1265 T1996 T1997 det a,allele
R1266 T1997 T1995 pobj allele,with
R1267 T1998 T1997 amod viable,allele
R1268 T1999 T1997 compound XpdTTD,allele
R1269 T2000 T1973 prep by,combined
R1270 T2001 T2000 pcomp crossing,by
R1271 T2002 T2003 det the,animals
R1272 T2003 T2001 dobj animals,crossing
R1273 T2004 T2003 amod corresponding,animals
R1274 T2005 T2003 amod heterozygous,animals
R1275 T2006 T1973 punct .,combined
R1276 T2008 T2009 advcl Similar,born
R1277 T2010 T2008 prep to,Similar
R1278 T2011 T2012 amod hemizygous,mice
R1279 T2012 T2010 pobj mice,to
R1280 T2013 T2012 compound TTD,mice
R1281 T2014 T2012 acl carrying,mice
R1282 T2015 T2016 nummod one,allele
R1283 T2016 T2014 dobj allele,carrying
R1284 T2017 T2016 amod true,allele
R1285 T2018 T2019 compound Xpd,knockout
R1286 T2019 T2016 compound knockout,allele
R1287 T2020 T2021 punct (,KO
R1288 T2021 T2016 parataxis KO,allele
R1289 T2022 T2021 compound XpdTTD,KO
R1290 T2023 T2021 punct /,KO
R1291 T2024 T2021 punct ),KO
R1292 T2025 T2009 punct ", ",born
R1293 T2026 T2027 nmod compound,mice
R1294 T2027 T2009 nsubjpass mice,born
R1295 T2028 T2027 amod heterozygous,mice
R1296 T2029 T2030 compound XpdTTD,†XPCS
R1297 T2030 T2027 compound †XPCS,mice
R1298 T2031 T2030 punct /,†XPCS
R1299 T2032 T2009 auxpass were,born
R1300 T2033 T2009 prep at,born
R1301 T2034 T2035 det the,frequencies
R1302 T2035 T2033 pobj frequencies,at
R1303 T2036 T2035 amod expected,frequencies
R1304 T2037 T2035 amod Mendelian,frequencies
R1305 T2038 T2009 punct .,born
R1306 T2040 T2041 nsubjpass Expression,reduced
R1307 T2042 T2040 prep from,Expression
R1308 T2043 T2044 det the,allele
R1309 T2044 T2042 pobj allele,from
R1310 T2045 T2044 compound Xpd†XPCS,allele
R1311 T2046 T2041 auxpass was,reduced
R1312 T2047 T2041 advmod also,reduced
R1313 T2048 T2041 prep in,reduced
R1314 T2049 T2050 det the,testis
R1315 T2050 T2048 pobj testis,in
R1316 T2051 T2050 prep of,testis
R1317 T2052 T2053 nmod compound,animals
R1318 T2053 T2051 pobj animals,of
R1319 T2054 T2053 amod heterozygous,animals
R1320 T2055 T2041 punct ", ",reduced
R1321 T2056 T2057 mark whereas,increased
R1322 T2057 T2041 advcl increased,reduced
R1323 T2058 T2057 nsubjpass expression,increased
R1324 T2059 T2058 prep from,expression
R1325 T2060 T2061 det the,allele
R1326 T2061 T2059 pobj allele,from
R1327 T2062 T2061 compound XpdTTD,allele
R1328 T2063 T2057 auxpass was,increased
R1329 T2064 T2057 advcl relative,increased
R1330 T2065 T2064 prep to,relative
R1331 T2066 T2065 pobj wt,to
R1332 T2067 T2057 prep by,increased
R1333 T2068 T2069 punct ~,5-fold
R1334 T2069 T2067 pobj 5-fold,by
R1335 T2070 T2071 punct (,1E
R1336 T2071 T2057 parataxis 1E,increased
R1337 T2072 T2071 compound Figure,1E
R1338 T2073 T2071 punct ),1E
R1339 T2074 T2041 punct .,reduced
R1340 T2076 T2077 prep Because,were
R1341 T2078 T2076 pcomp of,Because
R1342 T2079 T2080 det a,lack
R1343 T2080 T2076 pobj lack,Because
R1344 T2081 T2080 prep of,lack
R1345 T2082 T2083 amod available,antibodies
R1346 T2083 T2081 pobj antibodies,of
R1347 T2084 T2083 cc and,antibodies
R1348 T2085 T2086 det the,inability
R1349 T2086 T2083 conj inability,antibodies
R1350 T2087 T2088 aux to,distinguish
R1351 T2088 T2086 acl distinguish,inability
R1352 T2089 T2088 prep amongst,distinguish
R1353 T2090 T2091 amod various,forms
R1354 T2091 T2089 pobj forms,amongst
R1355 T2092 T2091 amod mutant,forms
R1356 T2093 T2091 prep of,forms
R1357 T2094 T2093 pobj XPD,of
R1358 T2095 T2091 acl differing,forms
R1359 T2096 T2095 advmod only,differing
R1360 T2097 T2095 prep by,differing
R1361 T2098 T2099 amod single,substitutions
R1362 T2099 T2097 pobj substitutions,by
R1363 T2100 T2101 compound amino,acid
R1364 T2101 T2099 compound acid,substitutions
R1365 T2102 T2077 punct ", ",were
R1366 T2103 T2077 nsubj we,were
R1367 T2104 T2077 acomp unable,were
R1368 T2105 T2106 aux to,ascertain
R1369 T2106 T2104 xcomp ascertain,unable
R1370 T2107 T2108 det the,amount
R1371 T2108 T2106 dobj amount,ascertain
R1372 T2109 T2108 amod relative,amount
R1373 T2110 T2108 prep of,amount
R1374 T2111 T2112 compound XPD,protein
R1375 T2112 T2110 pobj protein,of
R1376 T2113 T2112 prep from,protein
R1377 T2114 T2115 det the,alleles
R1378 T2115 T2113 pobj alleles,from
R1379 T2116 T2115 amod different,alleles
R1380 T2117 T2077 punct .,were
R1381 T2119 T2120 prep Despite,ameliorated
R1382 T2121 T2122 amod reduced,levels
R1383 T2122 T2119 pobj levels,Despite
R1384 T2123 T2122 prep of,levels
R1385 T2124 T2125 compound mRNA,expression
R1386 T2125 T2123 pobj expression,of
R1387 T2126 T2120 punct ", ",ameliorated
R1388 T2127 T2128 det the,allele
R1389 T2128 T2120 nsubj allele,ameliorated
R1390 T2129 T2128 amod homozygous,allele
R1391 T2130 T2128 amod lethal,allele
R1392 T2131 T2128 compound Xpd†XPCS,allele
R1393 T2132 T2133 amod multiple,symptoms
R1394 T2133 T2120 dobj symptoms,ameliorated
R1395 T2134 T2135 npadvmod XpdTTD,associated
R1396 T2135 T2133 amod associated,symptoms
R1397 T2136 T2135 punct -,associated
R1398 T2137 T2133 compound disease,symptoms
R1399 T2138 T2120 prep in,ameliorated
R1400 T2139 T2140 amod compound,animals
R1401 T2140 T2138 pobj animals,in
R1402 T2141 T2140 amod heterozygous,animals
R1403 T2142 T2143 compound XpdTTD,†XPCS
R1404 T2143 T2140 compound †XPCS,animals
R1405 T2144 T2143 punct /,†XPCS
R1406 T2145 T2120 prep including,ameliorated
R1407 T2146 T2147 det the,hair
R1408 T2147 T2145 pobj hair,including
R1409 T2148 T2147 nmod hallmark,hair
R1410 T2149 T2147 amod brittle,hair
R1411 T2150 T2147 cc and,hair
R1412 T2151 T2152 amod cutaneous,features
R1413 T2152 T2147 conj features,hair
R1414 T2153 T2154 advmod fully,penetrant
R1415 T2154 T2147 amod penetrant,hair
R1416 T2155 T2154 prep in,penetrant
R1417 T2156 T2157 advmod homo,hemizygous
R1418 T2157 T2160 amod hemizygous,mice
R1419 T2158 T2157 punct -,hemizygous
R1420 T2159 T2157 cc and,hemizygous
R1421 T2160 T2155 pobj mice,in
R1422 T2161 T2160 compound TTD,mice
R1423 T2162 T2163 punct (,2A
R1424 T2163 T2120 parataxis 2A,ameliorated
R1425 T2164 T2163 compound Figure,2A
R1426 T2165 T2166 punct –,2C
R1427 T2166 T2163 prep 2C,2A
R1428 T2167 T2163 punct ),2A
R1429 T2168 T2120 punct .,ameliorated
R1430 T2170 T2171 prep In,displayed
R1431 T2172 T2173 amod marked,contrast
R1432 T2173 T2170 pobj contrast,In
R1433 T2174 T2173 prep to,contrast
R1434 T2175 T2176 nmod XpdTTD,TTD
R1435 T2176 T2178 nmod TTD,mice
R1436 T2177 T2176 punct /,TTD
R1437 T2178 T2174 pobj mice,to
R1438 T2179 T2176 punct (,TTD
R1439 T2180 T2176 cc and,TTD
R1440 T2181 T2182 compound XpdTTD,KO
R1441 T2182 T2176 conj KO,TTD
R1442 T2183 T2182 punct /,KO
R1443 T2184 T2178 punct ),mice
R1444 T2185 T2178 punct ", ",mice
R1445 T2186 T2187 dep which,display
R1446 T2187 T2178 relcl display,mice
R1447 T2188 T2189 amod complete,loss
R1448 T2189 T2187 dobj loss,display
R1449 T2190 T2189 compound hair,loss
R1450 T2191 T2189 prep in,loss
R1451 T2192 T2193 det the,cycle
R1452 T2193 T2191 pobj cycle,in
R1453 T2194 T2193 amod first,cycle
R1454 T2195 T2193 compound hair,cycle
R1455 T2196 T2189 cc and,loss
R1456 T2197 T2198 amod partial,loss
R1457 T2198 T2189 conj loss,loss
R1458 T2199 T2198 compound hair,loss
R1459 T2200 T2198 prep in,loss
R1460 T2201 T2202 amod subsequent,cycles
R1461 T2202 T2200 pobj cycles,in
R1462 T2203 T2187 prep throughout,display
R1463 T2204 T2205 poss their,lives
R1464 T2205 T2203 pobj lives,throughout
R1465 T2206 T2207 punct [,21
R1466 T2207 T2187 parataxis 21,display
R1467 T2208 T2207 punct ],21
R1468 T2209 T2171 punct ", ",displayed
R1469 T2210 T2211 nmod compound,mice
R1470 T2211 T2171 nsubj mice,displayed
R1471 T2212 T2211 amod heterozygous,mice
R1472 T2213 T2211 compound XpdTTD/†XPCS,mice
R1473 T2214 T2215 det some,loss
R1474 T2215 T2171 dobj loss,displayed
R1475 T2216 T2215 compound hair,loss
R1476 T2217 T2218 advmod only,during
R1477 T2218 T2171 prep during,displayed
R1478 T2219 T2220 det the,cycle
R1479 T2220 T2218 pobj cycle,during
R1480 T2221 T2220 amod first,cycle
R1481 T2222 T2220 compound hair,cycle
R1482 T2223 T2218 cc and,during
R1483 T2224 T2225 advmod only,locally
R1484 T2225 T2226 advmod locally,at
R1485 T2226 T2218 conj at,during
R1486 T2227 T2228 det the,back
R1487 T2228 T2226 pobj back,at
R1488 T2229 T2230 punct (,2A
R1489 T2230 T2171 parataxis 2A,displayed
R1490 T2231 T2230 compound Figure,2A
R1491 T2232 T2230 punct ),2A
R1492 T2233 T2171 punct .,displayed
R1493 T2235 T2236 compound Scanning,microscope
R1494 T2236 T2238 compound microscope,analysis
R1495 T2237 T2236 compound electron,microscope
R1496 T2238 T2239 nsubj analysis,revealed
R1497 T2240 T2238 prep of,analysis
R1498 T2241 T2242 compound XpdTTD,†XPCS
R1499 T2242 T2244 compound †XPCS,hair
R1500 T2243 T2242 punct /,†XPCS
R1501 T2244 T2240 pobj hair,of
R1502 T2245 T2246 det an,appearance
R1503 T2246 T2239 dobj appearance,revealed
R1504 T2247 T2248 advmod almost,normal
R1505 T2248 T2246 amod normal,appearance
R1506 T2249 T2246 punct ", ",appearance
R1507 T2250 T2246 prep with,appearance
R1508 T2251 T2252 npadvmod TTD,like
R1509 T2252 T2254 amod like,features
R1510 T2253 T2252 punct -,like
R1511 T2254 T2250 pobj features,with
R1512 T2255 T2256 amod such,as
R1513 T2256 T2254 prep as,features
R1514 T2257 T2258 amod broken,hairs
R1515 T2258 T2256 pobj hairs,as
R1516 T2259 T2254 acl found,features
R1517 T2260 T2261 advmod only,at
R1518 T2261 T2259 prep at,found
R1519 T2262 T2263 advmod very,low
R1520 T2263 T2264 amod low,frequency
R1521 T2264 T2261 pobj frequency,at
R1522 T2265 T2266 punct (,data
R1523 T2266 T2239 parataxis data,revealed
R1524 T2267 T2266 amod unpublished,data
R1525 T2268 T2266 punct ),data
R1526 T2269 T2239 punct .,revealed
R1527 T2271 T2272 compound Amino,acid
R1528 T2272 T2273 compound acid,analysis
R1529 T2273 T2274 nsubj analysis,confirmed
R1530 T2275 T2276 mark that,were
R1531 T2276 T2274 ccomp were,confirmed
R1532 T2277 T2278 compound cysteine,levels
R1533 T2278 T2276 nsubj levels,were
R1534 T2279 T2278 prep in,levels
R1535 T2280 T2281 det the,hair
R1536 T2281 T2279 pobj hair,in
R1537 T2282 T2281 prep of,hair
R1538 T2283 T2284 det the,mice
R1539 T2284 T2282 pobj mice,of
R1540 T2285 T2286 compound XpdTTD,†XPCS
R1541 T2286 T2284 compound †XPCS,mice
R1542 T2287 T2286 punct /,†XPCS
R1543 T2288 T2289 advmod significantly,higher
R1544 T2289 T2276 acomp higher,were
R1545 T2290 T2289 prep than,higher
R1546 T2291 T2290 prep in,than
R1547 T2292 T2293 compound XpdTTD,TTD
R1548 T2293 T2295 compound TTD,animals
R1549 T2294 T2293 punct /,TTD
R1550 T2295 T2291 pobj animals,in
R1551 T2296 T2276 punct ", ",were
R1552 T2297 T2276 cc but,were
R1553 T2298 T2276 conj remained,were
R1554 T2299 T2298 prep below,remained
R1555 T2300 T2301 det the,level
R1556 T2301 T2299 pobj level,below
R1557 T2302 T2301 compound wt,level
R1558 T2303 T2304 punct (,2C
R1559 T2304 T2274 parataxis 2C,confirmed
R1560 T2305 T2304 compound Figure,2C
R1561 T2306 T2304 punct ),2C
R1562 T2307 T2274 punct .,confirmed
R1563 T2309 T2310 compound TTD,hemizygotes
R1564 T2310 T2311 nsubj hemizygotes,display
R1565 T2312 T2313 punct (,KO
R1566 T2313 T2310 parataxis KO,hemizygotes
R1567 T2314 T2313 compound XpdTTD,KO
R1568 T2315 T2313 punct /,KO
R1569 T2316 T2313 punct ),KO
R1570 T2317 T2311 aux do,display
R1571 T2318 T2311 neg not,display
R1572 T2319 T2320 amod significant,differences
R1573 T2320 T2311 dobj differences,display
R1574 T2321 T2320 prep in,differences
R1575 T2322 T2323 amod cutaneous,features
R1576 T2323 T2321 pobj features,in
R1577 T2324 T2323 cc and,features
R1578 T2325 T2323 conj longevity,features
R1579 T2326 T2320 amod relative,differences
R1580 T2327 T2326 prep to,relative
R1581 T2328 T2329 amod homozygous,mice
R1582 T2329 T2327 pobj mice,to
R1583 T2330 T2331 compound XpdTTD,TTD
R1584 T2331 T2329 compound TTD,mice
R1585 T2332 T2331 punct /,TTD
R1586 T2333 T2334 punct [,21
R1587 T2334 T2311 parataxis 21,display
R1588 T2335 T2334 punct ],21
R1589 T2336 T2311 punct .,display
R1590 T2338 T2339 amod Other,features
R1591 T2339 T2342 nsubj features,were
R1592 T2340 T2339 amod prominent,features
R1593 T2341 T2339 compound TTD,features
R1594 T2343 T2339 prep in,features
R1595 T2344 T2345 det the,epidermis
R1596 T2345 T2343 pobj epidermis,in
R1597 T2346 T2339 punct ", ",features
R1598 T2347 T2339 prep including,features
R1599 T2348 T2347 pobj acanthosis,including
R1600 T2349 T2350 punct (,thickening
R1601 T2350 T2348 parataxis thickening,acanthosis
R1602 T2351 T2350 prep of,thickening
R1603 T2352 T2353 det the,layer
R1604 T2353 T2351 pobj layer,of
R1605 T2354 T2353 prep of,layer
R1606 T2355 T2356 det the,cells
R1607 T2356 T2354 pobj cells,of
R1608 T2357 T2356 amod nucleated,cells
R1609 T2358 T2350 punct ),thickening
R1610 T2359 T2348 punct ", ",acanthosis
R1611 T2360 T2348 conj hyperkeratosis,acanthosis
R1612 T2361 T2362 punct (,thickening
R1613 T2362 T2360 parataxis thickening,hyperkeratosis
R1614 T2363 T2362 amod prominent,thickening
R1615 T2364 T2362 prep of,thickening
R1616 T2365 T2366 det the,layer
R1617 T2366 T2364 pobj layer,of
R1618 T2367 T2366 amod cornified,layer
R1619 T2368 T2362 punct ),thickening
R1620 T2369 T2360 punct ", ",hyperkeratosis
R1621 T2370 T2360 cc and,hyperkeratosis
R1622 T2371 T2372 amod pronounced,layer
R1623 T2372 T2360 conj layer,hyperkeratosis
R1624 T2373 T2372 amod granular,layer
R1625 T2374 T2372 cc and,layer
R1626 T2375 T2376 amod sebacious,gland
R1627 T2376 T2377 compound gland,hyperplasia
R1628 T2377 T2372 conj hyperplasia,layer
R1629 T2378 T2379 punct (,causing
R1630 T2379 T2377 parataxis causing,hyperplasia
R1631 T2380 T2381 amod greasy,appearance
R1632 T2381 T2379 dobj appearance,causing
R1633 T2382 T2381 prep of,appearance
R1634 T2383 T2384 det the,hair
R1635 T2384 T2382 pobj hair,of
R1636 T2385 T2379 punct ),causing
R1637 T2386 T2342 punct ", ",were
R1638 T2387 T2342 acomp absent,were
R1639 T2388 T2342 prep in,were
R1640 T2389 T2390 det the,skin
R1641 T2390 T2388 pobj skin,in
R1642 T2391 T2390 prep of,skin
R1643 T2392 T2393 compound XpdTTD,†XPCS
R1644 T2393 T2395 compound †XPCS,mice
R1645 T2394 T2393 punct /,†XPCS
R1646 T2395 T2391 pobj mice,of
R1647 T2396 T2342 punct ", ",were
R1648 T2397 T2398 mark as,established
R1649 T2398 T2342 advcl established,were
R1650 T2399 T2398 prep by,established
R1651 T2400 T2401 amod blind,examination
R1652 T2401 T2399 pobj examination,by
R1653 T2402 T2401 amod microscopic,examination
R1654 T2403 T2401 prep of,examination
R1655 T2404 T2405 compound skin,sections
R1656 T2405 T2403 pobj sections,of
R1657 T2406 T2407 punct (,2B
R1658 T2407 T2342 parataxis 2B,were
R1659 T2408 T2407 compound Figure,2B
R1660 T2409 T2407 punct ),2B
R1661 T2410 T2342 punct .,were
R1662 T2412 T2413 advmod Furthermore,rescued
R1663 T2414 T2413 punct ", ",rescued
R1664 T2415 T2413 nsubjpass anaemia,rescued
R1665 T2416 T2415 cc and,anaemia
R1666 T2417 T2418 amod developmental,delay
R1667 T2418 T2415 conj delay,anaemia
R1668 T2419 T2415 amod present,anaemia
R1669 T2420 T2419 prep in,present
R1670 T2421 T2420 pobj patients,in
R1671 T2422 T2421 prep with,patients
R1672 T2423 T2422 pobj TTD,with
R1673 T2424 T2425 punct [,24
R1674 T2425 T2421 parataxis 24,patients
R1675 T2426 T2425 punct ],24
R1676 T2427 T2420 cc and,in
R1677 T2428 T2420 conj in,in
R1678 T2429 T2430 compound XpdTTD,TTD
R1679 T2430 T2432 compound TTD,mice
R1680 T2431 T2430 punct /,TTD
R1681 T2432 T2428 pobj mice,in
R1682 T2433 T2434 punct [,15
R1683 T2434 T2432 parataxis 15,mice
R1684 T2435 T2434 punct ],15
R1685 T2436 T2413 auxpass were,rescued
R1686 T2437 T2413 advmod both,rescued
R1687 T2438 T2413 advmod partially,rescued
R1688 T2439 T2413 prep in,rescued
R1689 T2440 T2441 amod compound,mice
R1690 T2441 T2439 pobj mice,in
R1691 T2442 T2441 amod heterozygous,mice
R1692 T2443 T2444 compound XpdTTD,†XPCS
R1693 T2444 T2441 compound †XPCS,mice
R1694 T2445 T2444 punct /,†XPCS
R1695 T2446 T2447 punct (,2D
R1696 T2447 T2413 parataxis 2D,rescued
R1697 T2448 T2447 compound Figure,2D
R1698 T2449 T2447 cc and,2D
R1699 T2450 T2447 conj 2E,2D
R1700 T2451 T2447 punct ),2D
R1701 T2452 T2413 punct .,rescued
R1706 T2577 T2578 compound TTD,Mice
R1707 T2578 T2576 pobj Mice,in
R1709 T2580 T2581 amod Homozygous,Alleles
R1710 T2581 T2579 pobj Alleles,by
R1711 T2582 T2581 amod Lethal,Alleles
R1712 T2583 T2581 compound Xpd,Alleles
R1713 T2585 T2586 mark Because,share
R1714 T2586 T2605 advcl share,addressed
R1715 T2587 T2586 nsubj patients,share
R1716 T2588 T2587 prep with,patients
R1717 T2589 T2588 pobj TTD,with
R1718 T2590 T2589 punct ", ",TTD
R1719 T2591 T2589 conj XPCS,TTD
R1720 T2592 T2591 punct ", ",XPCS
R1721 T2593 T2591 cc and,XPCS
R1722 T2594 T2591 conj CS,XPCS
R1723 T2595 T2589 punct (,TTD
R1724 T2596 T2589 cc but,TTD
R1725 T2597 T2596 neg not,but
R1726 T2598 T2589 conj XP,TTD
R1727 T2599 T2587 punct ),patients
R1728 T2600 T2587 cc and,patients
R1729 T2601 T2602 det the,models
R1730 T2602 T2587 conj models,patients
R1731 T2603 T2602 amod corresponding,models
R1732 T2604 T2602 compound mouse,models
R1733 T2606 T2607 amod similar,symptoms
R1734 T2607 T2586 dobj symptoms,share
R1735 T2608 T2607 amod accelerated,symptoms
R1736 T2609 T2607 compound progeroid,symptoms
R1737 T2610 T2611 punct [,23
R1738 T2611 T2586 parataxis 23,share
R1739 T2612 T2611 nummod 12,23
R1740 T2613 T2611 punct ",",23
R1741 T2614 T2611 nummod 13,23
R1742 T2615 T2611 punct ",",23
R1743 T2616 T2611 nummod 15,23
R1744 T2617 T2611 punct ",",23
R1745 T2618 T2611 punct ],23
R1746 T2619 T2605 punct ", ",addressed
R1747 T2620 T2605 nsubj we,addressed
R1748 T2621 T2605 advmod next,addressed
R1749 T2622 T2623 amod ageing,related
R1750 T2623 T2625 amod related,parameters
R1751 T2624 T2623 punct -,related
R1752 T2625 T2605 dobj parameters,addressed
R1753 T2626 T2625 prep in,parameters
R1754 T2627 T2628 amod compound,mice
R1755 T2628 T2626 pobj mice,in
R1756 T2629 T2628 amod heterozygous,mice
R1757 T2630 T2631 punct (,Figure
R1758 T2631 T2605 parataxis Figure,addressed
R1759 T2632 T2631 nummod 3,Figure
R1760 T2633 T2631 punct ),Figure
R1761 T2634 T2605 punct .,addressed
R1762 T2636 T2637 mark Whereas,show
R1763 T2637 T2642 advcl show,were
R1764 T2638 T2639 compound XpdTTD,TTD
R1765 T2639 T2641 compound TTD,animals
R1766 T2640 T2639 punct /,TTD
R1767 T2641 T2637 nsubj animals,show
R1768 T2643 T2644 amod reduced,density
R1769 T2644 T2637 dobj density,show
R1770 T2645 T2646 compound bone,mineral
R1771 T2646 T2644 compound mineral,density
R1772 T2647 T2637 prep as,show
R1773 T2648 T2649 det an,indication
R1774 T2649 T2647 pobj indication,as
R1775 T2650 T2649 prep of,indication
R1776 T2651 T2652 det the,onset
R1777 T2652 T2650 pobj onset,of
R1778 T2653 T2652 amod early,onset
R1779 T2654 T2652 prep of,onset
R1780 T2655 T2654 pobj osteoporosis,of
R1781 T2656 T2652 prep before,onset
R1782 T2657 T2658 punct ~,14
R1783 T2658 T2659 nummod 14,mo
R1784 T2659 T2656 pobj mo,before
R1785 T2660 T2659 prep of,mo
R1786 T2661 T2660 pobj age,of
R1787 T2662 T2663 punct [,15
R1788 T2663 T2637 parataxis 15,show
R1789 T2664 T2663 punct ],15
R1790 T2665 T2642 punct ", ",were
R1791 T2666 T2667 compound tail,vertebrae
R1792 T2667 T2642 nsubj vertebrae,were
R1793 T2668 T2667 prep from,vertebrae
R1794 T2669 T2670 nmod compound,mice
R1795 T2670 T2668 pobj mice,from
R1796 T2671 T2670 amod heterozygous,mice
R1797 T2672 T2673 compound XpdTTD,†XPCS
R1798 T2673 T2670 compound †XPCS,mice
R1799 T2674 T2673 punct /,†XPCS
R1800 T2675 T2642 acomp comparable,were
R1801 T2676 T2675 prep to,comparable
R1802 T2677 T2676 pobj wt,to
R1803 T2678 T2679 advmod even,at
R1804 T2679 T2642 prep at,were
R1805 T2680 T2681 nummod 20,mo
R1806 T2681 T2679 pobj mo,at
R1807 T2682 T2681 prep of,mo
R1808 T2683 T2682 pobj age,of
R1809 T2684 T2685 punct (,3B
R1810 T2685 T2642 parataxis 3B,were
R1811 T2686 T2685 compound Figure,3B
R1812 T2687 T2685 cc and,3B
R1813 T2688 T2685 conj 3C,3B
R1814 T2689 T2685 punct ),3B
R1815 T2690 T2642 punct .,were
R1816 T2692 T2693 advmod Furthermore,3B
R1817 T2694 T2693 punct ", ",3B
R1818 T2695 T2696 mark whereas,developed
R1819 T2696 T2693 advcl developed,3B
R1820 T2697 T2698 compound XpdTTD,TTD
R1821 T2698 T2700 compound TTD,mice
R1822 T2699 T2698 punct /,TTD
R1823 T2700 T2696 nsubj mice,developed
R1824 T2701 T2696 dobj kyphosis,developed
R1825 T2702 T2696 advmod earlier,developed
R1826 T2703 T2702 prep than,earlier
R1827 T2704 T2705 compound wt,animals
R1828 T2705 T2703 pobj animals,than
R1829 T2706 T2707 punct (,onset
R1830 T2707 T2702 parataxis onset,earlier
R1831 T2708 T2709 punct ~,3
R1832 T2709 T2710 nummod 3,mo
R1833 T2710 T2707 npadvmod mo,onset
R1834 T2711 T2710 cc versus,mo
R1835 T2712 T2713 quantmod 12,20
R1836 T2713 T2715 nummod 20,mo
R1837 T2714 T2713 punct –,20
R1838 T2715 T2710 conj mo,mo
R1839 T2716 T2707 punct ),onset
R1840 T2717 T2693 punct ", ",3B
R1841 T2718 T2719 amod compound,mice
R1842 T2719 T2693 nsubj mice,3B
R1843 T2720 T2719 amod heterozygous,mice
R1844 T2721 T2722 compound XpdTTD,†XPCS
R1845 T2722 T2719 compound †XPCS,mice
R1846 T2723 T2722 punct /,†XPCS
R1847 T2724 T2693 aux did,3B
R1848 T2725 T2693 neg not,3B
R1849 T2726 T2693 punct (,3B
R1850 T2727 T2693 compound Figure,3B
R1851 T2728 T2693 punct ),3B
R1852 T2729 T2693 punct .,3B
R1853 T2731 T2732 amod Overall,appearance
R1854 T2732 T2733 nsubj appearance,revealed
R1855 T2734 T2732 cc and,appearance
R1856 T2735 T2736 compound body,weight
R1857 T2736 T2737 compound weight,curves
R1858 T2737 T2732 conj curves,appearance
R1859 T2738 T2739 mark that,rescued
R1860 T2739 T2733 ccomp rescued,revealed
R1861 T2740 T2741 npadvmod TTD,associated
R1862 T2741 T2743 amod associated,cachexia
R1863 T2742 T2741 punct -,associated
R1864 T2743 T2739 nsubjpass cachexia,rescued
R1865 T2744 T2745 npadvmod age,related
R1866 T2745 T2743 amod related,cachexia
R1867 T2746 T2745 punct -,related
R1868 T2747 T2743 amod premature,cachexia
R1869 T2748 T2743 cc and,cachexia
R1870 T2749 T2743 conj lack,cachexia
R1871 T2750 T2749 prep of,lack
R1872 T2751 T2752 amod general,fitness
R1873 T2752 T2750 pobj fitness,of
R1874 T2753 T2739 auxpass were,rescued
R1875 T2754 T2739 advmod fully,rescued
R1876 T2755 T2739 prep in,rescued
R1877 T2756 T2757 amod compound,mice
R1878 T2757 T2755 pobj mice,in
R1879 T2758 T2757 amod heterozygous,mice
R1880 T2759 T2760 compound XpdTTD,†XPCS
R1881 T2760 T2757 compound †XPCS,mice
R1882 T2761 T2760 punct /,†XPCS
R1883 T2762 T2763 punct (,3A
R1884 T2763 T2733 parataxis 3A,revealed
R1885 T2764 T2763 compound Figure,3A
R1886 T2765 T2763 cc and,3A
R1887 T2766 T2763 conj 3D,3A
R1888 T2767 T2763 punct ),3A
R1889 T2768 T2733 punct .,revealed
R1890 T2770 T2771 advmod Finally,extended
R1891 T2772 T2771 punct ", ",extended
R1892 T2773 T2774 det the,span
R1893 T2774 T2771 nsubjpass span,extended
R1894 T2775 T2774 compound life,span
R1895 T2776 T2774 prep of,span
R1896 T2777 T2778 amod compound,heterozygotes
R1897 T2778 T2776 pobj heterozygotes,of
R1898 T2779 T2771 auxpass was,extended
R1899 T2780 T2771 advcl relative,extended
R1900 T2781 T2780 prep to,relative
R1901 T2782 T2783 compound XpdTTD,TTD
R1902 T2783 T2785 compound TTD,mice
R1903 T2784 T2783 punct /,TTD
R1904 T2785 T2781 pobj mice,to
R1905 T2786 T2787 punct (,Table
R1906 T2787 T2771 parataxis Table,extended
R1907 T2788 T2787 nummod 2,Table
R1908 T2789 T2787 punct ),Table
R1909 T2790 T2771 punct .,extended
R1910 T2792 T2793 aux To,determine
R1911 T2793 T2794 advcl determine,generated
R1912 T2795 T2796 mark whether,was
R1913 T2796 T2793 ccomp was,determine
R1914 T2797 T2798 det the,allele
R1915 T2798 T2796 nsubj allele,was
R1916 T2799 T2798 amod homozygous,allele
R1917 T2800 T2798 amod lethal,allele
R1918 T2801 T2798 compound Xpd†XPCS,allele
R1919 T2802 T2796 acomp unique,was
R1920 T2803 T2802 prep in,unique
R1921 T2804 T2805 poss its,ability
R1922 T2805 T2803 pobj ability,in
R1923 T2806 T2807 aux to,ameliorate
R1924 T2807 T2805 acl ameliorate,ability
R1925 T2808 T2807 dobj symptoms,ameliorate
R1926 T2809 T2808 acl associated,symptoms
R1927 T2810 T2809 prep with,associated
R1928 T2811 T2812 det the,allele
R1929 T2812 T2810 pobj allele,with
R1930 T2813 T2812 compound XpdTTD,allele
R1931 T2814 T2794 punct ", ",generated
R1932 T2815 T2794 nsubj we,generated
R1933 T2816 T2817 nmod compound,mice
R1934 T2817 T2794 dobj mice,generated
R1935 T2818 T2817 amod heterozygous,mice
R1936 T2819 T2820 compound XpdTTD,†XP
R1937 T2820 T2817 compound †XP,mice
R1938 T2821 T2820 punct /,†XP
R1939 T2822 T2794 prep by,generated
R1940 T2823 T2822 pcomp crossing,by
R1941 T2824 T2825 det the,animals
R1942 T2825 T2823 dobj animals,crossing
R1943 T2826 T2825 amod corresponding,animals
R1944 T2827 T2825 amod heterozygous,animals
R1945 T2828 T2794 punct .,generated
R1946 T2830 T2831 advcl Similar,rescued
R1947 T2832 T2830 prep to,Similar
R1948 T2833 T2834 det the,allele
R1949 T2834 T2832 pobj allele,to
R1950 T2835 T2834 compound Xpd †XPCS,allele
R1951 T2836 T2831 punct ", ",rescued
R1952 T2837 T2838 det the,allele
R1953 T2838 T2831 nsubj allele,rescued
R1954 T2839 T2838 amod homozygous,allele
R1955 T2840 T2838 amod lethal,allele
R1956 T2841 T2838 compound Xpd †XP,allele
R1957 T2842 T2843 amod cutaneous,symptoms
R1958 T2843 T2831 dobj symptoms,rescued
R1959 T2844 T2843 prep including,symptoms
R1960 T2845 T2846 compound hair,loss
R1961 T2846 T2844 pobj loss,including
R1962 T2847 T2848 punct (,data
R1963 T2848 T2846 parataxis data,loss
R1964 T2849 T2848 prep except,data
R1965 T2850 T2849 pcomp locally,except
R1966 T2851 T2850 prep during,locally
R1967 T2852 T2853 det the,round
R1968 T2853 T2851 pobj round,during
R1969 T2854 T2853 amod first,round
R1970 T2855 T2848 punct ;,data
R1971 T2856 T2848 amod unpublished,data
R1972 T2857 T2848 punct ),data
R1973 T2858 T2846 punct ", ",loss
R1974 T2859 T2860 amod reduced,content
R1975 T2860 T2846 conj content,loss
R1976 T2861 T2860 compound cysteine,content
R1977 T2862 T2863 punct (,index
R1978 T2863 T2860 parataxis index,content
R1979 T2864 T2863 compound cysteine,index
R1980 T2865 T2863 npadvmod 9.3,index
R1981 T2866 T2865 punct ±,9.3
R1982 T2867 T2868 nummod 0.9,deviation
R1983 T2868 T2865 appos deviation,9.3
R1984 T2869 T2868 amod standard,deviation
R1985 T2870 T2871 punct [,%
R1986 T2871 T2865 parataxis %,9.3
R1987 T2872 T2871 nummod 87,%
R1988 T2873 T2871 prep of,%
R1989 T2874 T2873 pobj wt,of
R1990 T2875 T2871 punct ],%
R1991 T2876 T2863 punct ", ",index
R1992 T2877 T2878 nsubj p,TTD
R1993 T2878 T2863 ccomp TTD,index
R1994 T2879 T2878 punct =,TTD
R1995 T2880 T2878 nummod 0.01,TTD
R1996 T2881 T2878 cc versus,TTD
R1997 T2882 T2863 punct ),index
R1998 T2883 T2860 punct ", ",content
R1999 T2884 T2885 npadvmod ageing,associated
R2000 T2885 T2887 amod associated,cachexia
R2001 T2886 T2885 punct -,associated
R2002 T2887 T2860 conj cachexia,content
R2003 T2888 T2887 amod premature,cachexia
R2004 T2889 T2890 punct (,were
R2005 T2890 T2887 parataxis were,cachexia
R2006 T2891 T2890 nsubj males,were
R2007 T2892 T2891 cc and,males
R2008 T2893 T2891 conj females,males
R2009 T2894 T2895 nummod 36.1,6.4
R2010 T2895 T2897 nummod 6.4,g
R2011 T2896 T2895 punct ±,6.4
R2012 T2897 T2890 attr g,were
R2013 T2898 T2899 punct [,%
R2014 T2899 T2897 parataxis %,g
R2015 T2900 T2899 nummod 93,%
R2016 T2901 T2899 prep of,%
R2017 T2902 T2901 pobj wt,of
R2018 T2903 T2899 punct ],%
R2019 T2904 T2897 cc and,g
R2020 T2905 T2906 nummod 39.2,3.2
R2021 T2906 T2908 nummod 3.2,g
R2022 T2907 T2906 punct ±,3.2
R2023 T2908 T2897 conj g,g
R2024 T2909 T2910 punct [,%
R2025 T2910 T2908 parataxis %,g
R2026 T2911 T2910 nummod 116,%
R2027 T2912 T2910 prep of,%
R2028 T2913 T2912 pobj wt,of
R2029 T2914 T2910 punct ],%
R2030 T2915 T2890 punct ", ",were
R2031 T2916 T2890 advmod respectively,were
R2032 T2917 T2890 punct ),were
R2033 T2918 T2887 punct ", ",cachexia
R2034 T2919 T2887 cc and,cachexia
R2035 T2920 T2921 amod reduced,span
R2036 T2921 T2887 conj span,cachexia
R2037 T2922 T2921 compound life,span
R2038 T2923 T2924 punct (,Table
R2039 T2924 T2831 parataxis Table,rescued
R2040 T2925 T2924 nummod 2,Table
R2041 T2926 T2924 punct ),Table
R2042 T2927 T2831 punct .,rescued
R2043 T2929 T2930 advcl Taken,indicate
R2044 T2931 T2929 advmod together,Taken
R2045 T2932 T2930 punct ", ",indicate
R2046 T2933 T2934 det these,data
R2047 T2934 T2930 nsubj data,indicate
R2048 T2935 T2936 mark that,were
R2049 T2936 T2930 ccomp were,indicate
R2050 T2937 T2938 nummod two,alleles
R2051 T2938 T2936 nsubj alleles,were
R2052 T2939 T2938 amod independent,alleles
R2053 T2940 T2938 punct ", ",alleles
R2054 T2941 T2942 dep which,are
R2055 T2942 T2938 relcl are,alleles
R2056 T2943 T2942 prep on,are
R2057 T2944 T2945 poss their,own
R2058 T2945 T2943 pobj own,on
R2059 T2946 T2942 acomp unable,are
R2060 T2947 T2948 aux to,support
R2061 T2948 T2946 xcomp support,unable
R2062 T2949 T2948 dobj viability,support
R2063 T2950 T2951 punct (,Table
R2064 T2951 T2948 parataxis Table,support
R2065 T2952 T2951 nummod 1,Table
R2066 T2953 T2951 punct ),Table
R2067 T2954 T2936 punct ", ",were
R2068 T2955 T2936 advmod nonetheless,were
R2069 T2956 T2936 acomp able,were
R2070 T2957 T2958 aux to,ameliorate
R2071 T2958 T2956 xcomp ameliorate,able
R2072 T2959 T2960 npadvmod TTD,associated
R2073 T2960 T2962 amod associated,phenotypes
R2074 T2961 T2960 punct -,associated
R2075 T2962 T2958 dobj phenotypes,ameliorate
R2076 T2963 T2964 advmod in,vivo
R2077 T2964 T2958 advmod vivo,ameliorate
R2078 T2965 T2966 punct (,Table
R2079 T2966 T2958 parataxis Table,ameliorate
R2080 T2967 T2966 nummod 2,Table
R2081 T2968 T2966 punct ),Table
R2082 T2969 T2930 punct .,indicate
R2083 T3312 T3313 amod Molecular,Mechanisms
R2084 T3314 T3313 prep of,Mechanisms
R2085 T3315 T3316 amod Biallelic,Effects
R2086 T3316 T3314 pobj Effects,of
R2087 T3318 T3319 nsubj We,turned
R2088 T3320 T3319 advmod next,turned
R2089 T3321 T3319 prep to,turned
R2090 T3322 T3323 npadvmod UV,based
R2091 T3323 T3325 amod based,assays
R2092 T3324 T3323 punct -,based
R2093 T3325 T3321 pobj assays,to
R2094 T3326 T3325 amod cellular,assays
R2095 T3327 T3325 prep including,assays
R2096 T3328 T3329 amod unscheduled,synthesis
R2097 T3329 T3327 pobj synthesis,including
R2098 T3330 T3329 compound DNA,synthesis
R2099 T3331 T3329 prep after,synthesis
R2100 T3332 T3333 compound UV,irradiation
R2101 T3333 T3331 pobj irradiation,after
R2102 T3334 T3335 punct (,UDS
R2103 T3335 T3329 parataxis UDS,synthesis
R2104 T3336 T3335 compound UV,UDS
R2105 T3337 T3335 punct -,UDS
R2106 T3338 T3335 punct ),UDS
R2107 T3339 T3329 punct ", ",synthesis
R2108 T3340 T3329 conj recovery,synthesis
R2109 T3341 T3340 prep of,recovery
R2110 T3342 T3343 compound RNA,synthesis
R2111 T3343 T3341 pobj synthesis,of
R2112 T3344 T3340 prep after,recovery
R2113 T3345 T3346 compound UV,irradiation
R2114 T3346 T3344 pobj irradiation,after
R2115 T3347 T3348 punct (,RRS
R2116 T3348 T3340 parataxis RRS,recovery
R2117 T3349 T3348 compound UV,RRS
R2118 T3350 T3348 punct -,RRS
R2119 T3351 T3348 punct ),RRS
R2120 T3352 T3340 punct ", ",recovery
R2121 T3353 T3340 cc and,recovery
R2122 T3354 T3355 compound UV,survival
R2123 T3355 T3340 conj survival,recovery
R2124 T3356 T3329 punct ", ",synthesis
R2125 T3357 T3358 dep which,report
R2126 T3358 T3329 relcl report,synthesis
R2127 T3359 T3358 prep on,report
R2128 T3360 T3361 det the,subpathways
R2129 T3361 T3359 pobj subpathways,on
R2130 T3362 T3361 compound NER,subpathways
R2131 T3363 T3364 punct (,NER
R2132 T3364 T3361 parataxis NER,subpathways
R2133 T3365 T3364 amod global,NER
R2134 T3366 T3364 compound genome,NER
R2135 T3367 T3364 cc and,NER
R2136 T3368 T3369 npadvmod transcription,coupled
R2137 T3369 T3371 amod coupled,NER
R2138 T3370 T3369 punct -,coupled
R2139 T3371 T3364 conj NER,NER
R2140 T3372 T3364 punct ),NER
R2141 T3373 T3361 cc and,subpathways
R2142 T3374 T3375 amod total,NER
R2143 T3375 T3361 conj NER,subpathways
R2144 T3376 T3358 punct ", ",report
R2145 T3377 T3358 advmod respectively,report
R2146 T3378 T3319 punct .,turned
R2147 T3380 T3381 prep In,improved
R2148 T3382 T3380 pobj none,In
R2149 T3383 T3382 prep of,none
R2150 T3384 T3385 det these,assays
R2151 T3385 T3383 pobj assays,of
R2152 T3386 T3381 auxpass was,improved
R2153 T3387 T3388 det the,response
R2154 T3388 T3381 nsubjpass response,improved
R2155 T3389 T3388 prep to,response
R2156 T3390 T3389 pobj UV,to
R2157 T3391 T3381 prep in,improved
R2158 T3392 T3393 compound compound,heterozygotes
R2159 T3393 T3391 pobj heterozygotes,in
R2160 T3394 T3381 advcl relative,improved
R2161 T3395 T3394 prep to,relative
R2162 T3396 T3397 compound TTD,homozygotes
R2163 T3397 T3395 pobj homozygotes,to
R2164 T3398 T3399 punct (,4A
R2165 T3399 T3381 parataxis 4A,improved
R2166 T3400 T3399 compound Figure,4A
R2167 T3401 T3402 punct –,4C
R2168 T3402 T3399 prep 4C,4A
R2169 T3403 T3399 punct ),4A
R2170 T3404 T3381 punct .,improved
R2171 T3406 T3407 advmod However,observed
R2172 T3408 T3407 punct ", ",observed
R2173 T3409 T3407 prep unlike,observed
R2174 T3410 T3411 det the,phenotypes
R2175 T3411 T3409 pobj phenotypes,unlike
R2176 T3412 T3413 advmod in,vivo
R2177 T3413 T3411 amod vivo,phenotypes
R2178 T3414 T3411 compound TTD,phenotypes
R2179 T3415 T3411 acl described,phenotypes
R2180 T3416 T3415 advmod above,described
R2181 T3417 T3411 punct ", ",phenotypes
R2182 T3418 T3419 prep in,were
R2183 T3419 T3411 relcl were,phenotypes
R2184 T3420 T3418 pobj which,in
R2185 T3421 T3422 nmod XpdTTD,TTD
R2186 T3422 T3424 nmod TTD,animals
R2187 T3423 T3422 punct /,TTD
R2188 T3424 T3419 nsubj animals,were
R2189 T3425 T3422 cc and,TTD
R2190 T3426 T3427 compound XpdTTD,KO
R2191 T3427 T3422 conj KO,TTD
R2192 T3428 T3427 punct /,KO
R2193 T3429 T3419 acomp indistinguishable,were
R2194 T3430 T3407 punct ", ",observed
R2195 T3431 T3432 compound XpdTTD,effects
R2196 T3432 T3407 nsubjpass effects,observed
R2197 T3433 T3432 compound dosage,effects
R2198 T3434 T3407 auxpass were,observed
R2199 T3435 T3407 prep in,observed
R2200 T3436 T3437 compound UV,survival
R2201 T3437 T3435 pobj survival,in
R2202 T3438 T3437 punct ", ",survival
R2203 T3439 T3440 compound UV,UDS
R2204 T3440 T3437 conj UDS,survival
R2205 T3441 T3440 punct -,UDS
R2206 T3442 T3440 punct ", ",UDS
R2207 T3443 T3440 cc and,UDS
R2208 T3444 T3445 compound UV,RRS
R2209 T3445 T3440 conj RRS,UDS
R2210 T3446 T3445 punct -,RRS
R2211 T3447 T3407 punct ", ",observed
R2212 T3448 T3407 advcl indicating,observed
R2213 T3449 T3450 mark that,correlate
R2214 T3450 T3448 ccomp correlate,indicating
R2215 T3451 T3452 amod cellular,parameters
R2216 T3452 T3450 nsubj parameters,correlate
R2217 T3453 T3454 mark as,measured
R2218 T3454 T3452 advcl measured,parameters
R2219 T3455 T3454 prep in,measured
R2220 T3456 T3455 pobj fibroblasts,in
R2221 T3457 T3454 advmod here,measured
R2222 T3458 T3450 aux do,correlate
R2223 T3459 T3450 neg not,correlate
R2224 T3460 T3450 advmod always,correlate
R2225 T3461 T3450 prep with,correlate
R2226 T3462 T3463 det the,phenotype
R2227 T3463 T3461 pobj phenotype,with
R2228 T3464 T3450 prep at,correlate
R2229 T3465 T3466 det the,level
R2230 T3466 T3464 pobj level,at
R2231 T3467 T3466 prep of,level
R2232 T3468 T3469 det the,organism
R2233 T3469 T3467 pobj organism,of
R2234 T3470 T3469 amod intact,organism
R2235 T3471 T3407 punct .,observed
R2236 T3473 T3474 nmod XpdTTD,KO
R2237 T3474 T3476 nmod KO,cells
R2238 T3475 T3474 punct /,KO
R2239 T3476 T3478 nsubjpass cells,used
R2240 T3477 T3476 amod hemizygous,cells
R2241 T3479 T3478 auxpass were,used
R2242 T3480 T3478 advmod thus,used
R2243 T3481 T3478 prep as,used
R2244 T3482 T3483 det the,baseline
R2245 T3483 T3481 pobj baseline,as
R2246 T3484 T3485 prep on,compare
R2247 T3485 T3483 relcl compare,baseline
R2248 T3486 T3484 pobj which,on
R2249 T3487 T3485 aux to,compare
R2250 T3488 T3489 det the,activity
R2251 T3489 T3485 dobj activity,compare
R2252 T3490 T3489 prep of,activity
R2253 T3491 T3492 nmod compound,cells
R2254 T3492 T3490 pobj cells,of
R2255 T3493 T3492 amod heterozygous,cells
R2256 T3494 T3478 punct .,used
R2257 T3496 T3497 advcl Relative,improved
R2258 T3498 T3496 prep to,Relative
R2259 T3499 T3500 compound XpdTTD,KO
R2260 T3500 T3502 compound KO,cells
R2261 T3501 T3500 punct /,KO
R2262 T3502 T3498 pobj cells,to
R2263 T3503 T3502 compound hemizygote,cells
R2264 T3504 T3497 punct ", ",improved
R2265 T3505 T3506 compound UV,survival
R2266 T3506 T3497 nsubjpass survival,improved
R2267 T3507 T3497 auxpass was,improved
R2268 T3508 T3497 prep by,improved
R2269 T3509 T3510 det the,allele
R2270 T3510 T3508 pobj allele,by
R2271 T3511 T3510 amod homozygous,allele
R2272 T3512 T3510 amod lethal,allele
R2273 T3513 T3510 compound Xpd†XPCS,allele
R2274 T3514 T3510 prep in,allele
R2275 T3515 T3516 nmod XpdTTD,†XPCS
R2276 T3516 T3518 nmod †XPCS,cells
R2277 T3517 T3516 punct /,†XPCS
R2278 T3518 T3514 pobj cells,in
R2279 T3519 T3518 nmod compound,cells
R2280 T3520 T3518 amod heterozygous,cells
R2281 T3521 T3508 cc and,by
R2282 T3522 T3523 prep to,by
R2283 T3523 T3508 conj by,by
R2284 T3524 T3525 det a,degree
R2285 T3525 T3522 pobj degree,to
R2286 T3526 T3525 amod lesser,degree
R2287 T3527 T3528 det the,allele
R2288 T3528 T3523 pobj allele,by
R2289 T3529 T3528 compound Xpd†XP,allele
R2290 T3530 T3531 punct (,4A
R2291 T3531 T3497 parataxis 4A,improved
R2292 T3532 T3531 compound Figure,4A
R2293 T3533 T3531 punct ),4A
R2294 T3534 T3497 punct .,improved
R2295 T3536 T3537 prep Because,were
R2296 T3538 T3536 pcomp of,Because
R2297 T3539 T3540 amod embryonic,lethality
R2298 T3540 T3536 pobj lethality,Because
R2299 T3541 T3539 cc and,embryonic
R2300 T3542 T3539 conj cellular,embryonic
R2301 T3543 T3537 punct ", ",were
R2302 T3544 T3537 nsubj we,were
R2303 T3545 T3537 acomp unable,were
R2304 T3546 T3547 aux to,test
R2305 T3547 T3545 xcomp test,unable
R2306 T3548 T3549 compound UV,survival
R2307 T3549 T3547 dobj survival,test
R2308 T3550 T3549 acl associated,survival
R2309 T3551 T3550 advmod exclusively,associated
R2310 T3552 T3550 prep with,associated
R2311 T3553 T3554 det the,alleles
R2312 T3554 T3552 pobj alleles,with
R2313 T3555 T3554 nmod Xpd†XPCS,alleles
R2314 T3556 T3555 cc or,Xpd†XPCS
R2315 T3557 T3555 conj Xpd†XP,Xpd†XPCS
R2316 T3558 T3537 punct .,were
R2317 T3560 T3561 advmod However,known
R2318 T3562 T3561 punct ", ",known
R2319 T3563 T3564 amod homozygous,XPDXP
R2320 T3564 T3565 nmod XPDXP,cells
R2321 T3565 T3561 nsubjpass cells,known
R2322 T3566 T3567 punct (,XPDR683W
R2323 T3567 T3564 parataxis XPDR683W,XPDXP
R2324 T3568 T3567 punct ),XPDR683W
R2325 T3569 T3564 cc and,XPDXP
R2326 T3570 T3571 amod hemizygous,XPDXPCS
R2327 T3571 T3564 conj XPDXPCS,XPDXP
R2328 T3572 T3573 punct (,XPDG602D
R2329 T3573 T3571 parataxis XPDG602D,XPDXPCS
R2330 T3574 T3573 punct ),XPDG602D
R2331 T3575 T3565 amod human,cells
R2332 T3576 T3561 auxpass are,known
R2333 T3577 T3578 aux to,be
R2334 T3578 T3561 xcomp be,known
R2335 T3579 T3580 advmod highly,sensitive
R2336 T3580 T3578 acomp sensitive,be
R2337 T3581 T3580 prep to,sensitive
R2338 T3582 T3581 pobj UV,to
R2339 T3583 T3584 punct [,25
R2340 T3584 T3578 parataxis 25,be
R2341 T3585 T3584 nummod 19,25
R2342 T3586 T3584 punct ",",25
R2343 T3587 T3584 punct ],25
R2344 T3588 T3561 punct ", ",known
R2345 T3589 T3590 mark as,are
R2346 T3590 T3561 advcl are,known
R2347 T3591 T3590 nsubj cells,are
R2348 T3592 T3591 prep from,cells
R2349 T3593 T3594 det a,model
R2350 T3594 T3592 pobj model,from
R2351 T3595 T3594 amod homozygous,model
R2352 T3596 T3594 amod viable,model
R2353 T3597 T3598 nmod XpdXPCS,XPCS
R2354 T3598 T3594 nmod XPCS,model
R2355 T3599 T3598 punct /,XPCS
R2356 T3600 T3601 punct (,G602D
R2357 T3601 T3598 parataxis G602D,XPCS
R2358 T3602 T3601 compound XPDG602D,G602D
R2359 T3603 T3601 punct /,G602D
R2360 T3604 T3601 punct ),G602D
R2361 T3605 T3594 compound mouse,model
R2362 T3606 T3607 punct (,4A
R2363 T3607 T3590 parataxis 4A,are
R2364 T3608 T3607 compound Figure,4A
R2365 T3609 T3607 punct ", ",4A
R2366 T3610 T3611 amod dotted,line
R2367 T3611 T3607 appos line,4A
R2368 T3612 T3607 punct ),4A
R2369 T3613 T3614 punct [,23
R2370 T3614 T3561 parataxis 23,known
R2371 T3615 T3614 punct ],23
R2372 T3616 T3561 punct .,known
R2373 T3618 T3619 advmod Thus,represents
R2374 T3620 T3619 punct ", ",represents
R2375 T3621 T3622 det the,survival
R2376 T3622 T3619 nsubj survival,represents
R2377 T3623 T3622 prep of,survival
R2378 T3624 T3625 nmod XpdTTD,†XPCS
R2379 T3625 T3627 nmod †XPCS,cells
R2380 T3626 T3625 punct /,†XPCS
R2381 T3627 T3623 pobj cells,of
R2382 T3628 T3625 punct (,†XPCS
R2383 T3629 T3625 cc and,†XPCS
R2384 T3630 T3631 compound XpdTTD,†XP
R2385 T3631 T3625 conj †XP,†XPCS
R2386 T3632 T3631 punct /,†XP
R2387 T3633 T3627 punct ),cells
R2388 T3634 T3619 advmod likely,represents
R2389 T3635 T3636 det a,level
R2390 T3636 T3619 dobj level,represents
R2391 T3637 T3636 prep of,level
R2392 T3638 T3639 compound UV,resistance
R2393 T3639 T3637 pobj resistance,of
R2394 T3640 T3641 dep that,impart
R2395 T3641 T3636 relcl impart,level
R2396 T3642 T3643 preconj neither,allele
R2397 T3643 T3641 nsubj allele,impart
R2398 T3644 T3643 amod mutant,allele
R2399 T3645 T3641 aux can,impart
R2400 T3646 T3641 prep on,impart
R2401 T3647 T3648 poss its,own
R2402 T3648 T3646 pobj own,on
R2403 T3649 T3650 punct (,Table
R2404 T3650 T3619 parataxis Table,represents
R2405 T3651 T3650 nummod 2,Table
R2406 T3652 T3650 punct ),Table
R2407 T3653 T3619 punct .,represents
R2408 T3655 T3656 amod Significant,effects
R2409 T3656 T3657 nsubjpass effects,observed
R2410 T3658 T3656 prep of,effects
R2411 T3659 T3660 compound compound,heterozygosity
R2412 T3660 T3658 pobj heterozygosity,of
R2413 T3661 T3656 prep on,effects
R2414 T3662 T3663 compound NER,subpathways
R2415 T3663 T3661 pobj subpathways,on
R2416 T3664 T3656 amod relative,effects
R2417 T3665 T3664 prep to,relative
R2418 T3666 T3667 compound XpdTTD,KO
R2419 T3667 T3669 compound KO,cells
R2420 T3668 T3667 punct /,KO
R2421 T3669 T3665 pobj cells,to
R2422 T3670 T3657 auxpass were,observed
R2423 T3671 T3657 prep in,observed
R2424 T3672 T3673 compound XpdTTD,†XP
R2425 T3673 T3675 compound †XP,cells
R2426 T3674 T3673 punct /,†XP
R2427 T3675 T3671 pobj cells,in
R2428 T3676 T3671 cc but,in
R2429 T3677 T3678 advmod only,for
R2430 T3678 T3671 conj for,in
R2431 T3679 T3680 compound UV,UDS
R2432 T3680 T3682 compound UDS,activity
R2433 T3681 T3680 punct -,UDS
R2434 T3682 T3678 pobj activity,for
R2435 T3683 T3657 punct .,observed
R2436 T3685 T3686 advmod Finally,exhibited
R2437 T3687 T3686 punct ", ",exhibited
R2438 T3688 T3686 nsubj none,exhibited
R2439 T3689 T3688 prep of,none
R2440 T3690 T3691 det the,combinations
R2441 T3691 T3689 pobj combinations,of
R2442 T3692 T3691 amod mutant,combinations
R2443 T3693 T3691 compound TFIIH,combinations
R2444 T3694 T3691 punct (,combinations
R2445 T3695 T3691 acl carrying,combinations
R2446 T3696 T3695 dobj alterations,carrying
R2447 T3697 T3696 acl associated,alterations
R2448 T3698 T3697 prep with,associated
R2449 T3699 T3698 pobj TTD,with
R2450 T3700 T3701 punct [,XPDR722W
R2451 T3701 T3699 parataxis XPDR722W,TTD
R2452 T3702 T3701 punct ],XPDR722W
R2453 T3703 T3699 punct ", ",TTD
R2454 T3704 T3699 conj XPCS,TTD
R2455 T3705 T3706 punct [,XPDG602D
R2456 T3706 T3704 parataxis XPDG602D,XPCS
R2457 T3707 T3706 punct ],XPDG602D
R2458 T3708 T3704 punct ", ",XPCS
R2459 T3709 T3704 cc or,XPCS
R246 T565 T566 amod Interallelic,complementation
R2460 T3710 T3704 conj XP,XPCS
R2461 T3711 T3712 punct [,XPDR683W
R2462 T3712 T3710 parataxis XPDR683W,XP
R2463 T3713 T3712 punct ],XPDR683W
R2464 T3714 T3686 punct ),exhibited
R2465 T3715 T3686 dobj synergism,exhibited
R2466 T3716 T3686 prep in,exhibited
R2467 T3717 T3718 det an,reaction
R2468 T3718 T3716 pobj reaction,in
R2469 T3719 T3720 advmod in,vitro
R247 T566 T567 nsubjpass complementation,defined
R2470 T3720 T3718 amod vitro,reaction
R2471 T3721 T3718 compound NER,reaction
R2472 T3722 T3718 acl reconstituted,reaction
R2473 T3723 T3722 prep with,reconstituted
R2474 T3724 T3725 amod different,complexes
R2475 T3725 T3723 pobj complexes,with
R2476 T3726 T3725 amod mutant,complexes
R2477 T3727 T3725 compound TFIIH,complexes
R2478 T3728 T3729 punct (,4D
R2479 T3729 T3686 parataxis 4D,exhibited
R248 T568 T567 auxpass is,defined
R2480 T3730 T3729 compound Figure,4D
R2481 T3731 T3729 punct ),4D
R2482 T3732 T3686 punct .,exhibited
R2483 T3734 T3735 advcl Taken,are
R2484 T3736 T3734 advmod together,Taken
R2485 T3737 T3735 punct ", ",are
R2486 T3738 T3739 det these,data
R2487 T3739 T3735 nsubj data,are
R2488 T3740 T3735 acomp consistent,are
R2489 T3741 T3740 prep with,consistent
R249 T569 T567 prep as,defined
R2490 T3742 T3743 amod interallelic,complementation
R2491 T3743 T3741 pobj complementation,with
R2492 T3744 T3743 prep of,complementation
R2493 T3745 T3746 compound UV,sensitivity
R2494 T3746 T3744 pobj sensitivity,of
R2495 T3747 T3743 prep in,complementation
R2496 T3748 T3747 pobj cells,in
R2497 T3749 T3735 cc but,are
R2498 T3750 T3735 conj underscore,are
R2499 T3751 T3752 det the,lack
R250 T570 T571 det the,ability
R2500 T3752 T3750 dobj lack,underscore
R2501 T3753 T3752 prep of,lack
R2502 T3754 T3755 det any,correlation
R2503 T3755 T3753 pobj correlation,of
R2504 T3756 T3755 prep between,correlation
R2505 T3757 T3758 npadvmod UV,related
R2506 T3758 T3760 amod related,characteristics
R2507 T3759 T3758 punct -,related
R2508 T3760 T3756 pobj characteristics,between
R2509 T3761 T3760 compound repair,characteristics
R251 T571 T569 pobj ability,as
R2510 T3762 T3760 cc and,characteristics
R2511 T3763 T3764 compound TTD,phenotypes
R2512 T3764 T3760 conj phenotypes,characteristics
R2513 T3765 T3764 compound progeroid,phenotypes
R2514 T3766 T3755 prep in,correlation
R2515 T3767 T3768 compound animal,models
R2516 T3768 T3766 pobj models,in
R2517 T3769 T3735 punct .,are
R2518 T3778 T3779 nsubj sk,e
R2519 T3779 T3780 ccomp e,t
R252 T572 T571 prep of,ability
R2520 T3781 T3779 dobj d,e
R2521 T3782 T3781 prep wh,d
R2522 T3783 T3780 nsubj e,t
R2523 T3789 T3790 det h,e
R2524 T3798 T3797 cc and,†XPCS
R2525 T3799 T3800 compound Xpd,†XP
R2526 T3800 T3797 conj †XP,†XPCS
R2527 T3801 T3802 amod a,l
R2528 T3804 T3805 nsubj l,e
R2529 T3806 T3805 dobj les,e
R253 T573 T574 nummod two,alleles
R2530 T3812 T3811 pobj e,it
R2531 T3817 T3818 amod re,a
R2532 T3821 T3820 cc d,e
R2533 T3822 T3820 conj m,e
R2534 T3826 T3825 compound RNA,levels
R2535 T3827 T3824 punct ", ",ameliorated
R2536 T3828 T3829 compound TTD,symptoms
R2537 T3829 T3824 dobj symptoms,ameliorated
R2538 T3830 T3824 prep by,ameliorated
R2539 T3831 T3832 amod increasing,levels
R254 T574 T572 pobj alleles,of
R2540 T3832 T3830 pobj levels,by
R2541 T3833 T3832 amod overall,levels
R2542 T3834 T3832 compound TFIIH,levels
R2543 T3835 T3824 prep in,ameliorated
R2544 T3836 T3837 nmod compound,cells
R2545 T3837 T3835 pobj cells,in
R2546 T3838 T3837 amod heterozygous,cells
R2547 T3839 T3840 nmod XpdTTD, †XPCS
R2548 T3840 T3837 nmod  †XPCS,cells
R2549 T3841 T3840 punct /, †XPCS
R255 T575 T576 advmod differentially,mutated
R2550 T3842 T3840 cc and, †XPCS
R2551 T3843 T3844 compound XpdTTD, †XP
R2552 T3844 T3840 conj  †XP, †XPCS
R2553 T3845 T3844 punct /, †XP
R2554 T3848 T3849 advmod Previously,shown
R2555 T3850 T3849 punct ", ",shown
R2556 T3851 T3849 advcl using,shown
R2557 T3852 T3853 amod comparative,immunohistochemistry
R2558 T3853 T3851 dobj immunohistochemistry,using
R2559 T3854 T3849 punct ", ",shown
R256 T576 T574 amod mutated,alleles
R2560 T3855 T3849 nsubj we,shown
R2561 T3856 T3855 cc and,we
R2562 T3857 T3855 conj others,we
R2563 T3858 T3849 aux have,shown
R2564 T3859 T3860 det an,reduction
R2565 T3860 T3849 dobj reduction,shown
R2566 T3861 T3862 quantmod up,70
R2567 T3862 T3864 nummod 70,%
R2568 T3863 T3862 quantmod to,70
R2569 T3864 T3860 compound %,reduction
R257 T577 T578 aux to,function
R2570 T3865 T3860 prep of,reduction
R2571 T3866 T3867 compound TFIIH,levels
R2572 T3867 T3865 pobj levels,of
R2573 T3868 T3867 prep in,levels
R2574 T3869 T3870 amod primary,fibroblasts
R2575 T3870 T3868 pobj fibroblasts,in
R2576 T3871 T3870 prep from,fibroblasts
R2577 T3872 T3871 pobj patients,from
R2578 T3873 T3872 prep with,patients
R2579 T3874 T3873 pobj TTD,with
R258 T578 T571 acl function,ability
R2580 T3875 T3860 prep compared,reduction
R2581 T3876 T3875 prep with,compared
R2582 T3877 T3878 compound wt,controls
R2583 T3878 T3876 pobj controls,with
R2584 T3879 T3860 prep due,reduction
R2585 T3880 T3879 pcomp to,due
R2586 T3881 T3882 amod reduced,stability
R2587 T3882 T3879 pobj stability,due
R2588 T3883 T3884 punct [,17
R2589 T3884 T3849 parataxis 17,shown
R259 T579 T578 advmod better,function
R2590 T3885 T3884 nummod 16,17
R2591 T3886 T3884 punct ",",17
R2592 T3887 T3884 punct ],17
R2593 T3888 T3849 punct .,shown
R2594 T3890 T3891 prep Despite,reduced
R2595 T3892 T3890 pobj overexpression,Despite
R2596 T3893 T3892 prep of,overexpression
R2597 T3894 T3893 pobj mRNA,of
R2598 T3895 T3894 prep from,mRNA
R2599 T3896 T3897 det the,allele
R260 T580 T578 advmod together,function
R2600 T3897 T3895 pobj allele,from
R2601 T3898 T3897 compound XpdTTD,allele
R2602 T3899 T3892 amod relative,overexpression
R2603 T3900 T3899 prep to,relative
R2604 T3901 T3902 det the,allele
R2605 T3902 T3900 pobj allele,to
R2606 T3903 T3902 compound wt,allele
R2607 T3904 T3905 punct (,1E
R2608 T3905 T3892 parataxis 1E,overexpression
R2609 T3906 T3905 compound Figure,1E
R261 T581 T582 mark than,can
R2610 T3907 T3905 punct ),1E
R2611 T3908 T3891 punct ", ",reduced
R2612 T3909 T3910 compound TFIIH,levels
R2613 T3910 T3891 nsubjpass levels,reduced
R2614 T3911 T3910 compound protein,levels
R2615 T3912 T3891 auxpass were,reduced
R2616 T3913 T3891 prep by,reduced
R2617 T3914 T3915 nummod 50,%
R2618 T3915 T3913 pobj %,by
R2619 T3916 T3891 prep in,reduced
R262 T582 T578 advcl can,function
R2620 T3917 T3918 amod primary,fibroblasts
R2621 T3918 T3916 pobj fibroblasts,in
R2622 T3919 T3918 compound mouse,fibroblasts
R2623 T3920 T3921 compound XpdTTD,TTD
R2624 T3921 T3918 compound TTD,fibroblasts
R2625 T3922 T3921 punct /,TTD
R2626 T3923 T3924 punct (,4E
R2627 T3924 T3891 parataxis 4E,reduced
R2628 T3925 T3924 compound Figure,4E
R2629 T3926 T3924 cc and,4E
R263 T583 T582 nsubj either,can
R2630 T3927 T3924 conj 4F,4E
R2631 T3928 T3924 punct ),4E
R2632 T3929 T3891 punct ", ",reduced
R2633 T3930 T3931 advmod thereby,mimicking
R2634 T3931 T3891 advcl mimicking,reduced
R2635 T3932 T3933 det the,situation
R2636 T3933 T3931 dobj situation,mimicking
R2637 T3934 T3931 prep in,mimicking
R2638 T3935 T3936 amod human,patients
R2639 T3936 T3934 pobj patients,in
R264 T584 T582 prep on,can
R2640 T3937 T3936 prep with,patients
R2641 T3938 T3937 pobj TTD,with
R2642 T3939 T3891 punct .,reduced
R2643 T3941 T3942 prep In,observed
R2644 T3943 T3941 pobj accordance,In
R2645 T3944 T3943 prep with,accordance
R2646 T3945 T3946 det the,dosage
R2647 T3946 T3944 pobj dosage,with
R2648 T3947 T3946 compound gene,dosage
R2649 T3948 T3942 punct ", ",observed
R265 T585 T586 poss its,own
R2650 T3949 T3950 det a,reduction
R2651 T3950 T3942 nsubjpass reduction,observed
R2652 T3951 T3950 amod further,reduction
R2653 T3952 T3950 prep of,reduction
R2654 T3953 T3954 quantmod up,70
R2655 T3954 T3956 nummod 70,%
R2656 T3955 T3954 quantmod to,70
R2657 T3956 T3952 pobj %,of
R2658 T3957 T3956 prep of,%
R2659 T3958 T3959 det the,level
R266 T586 T584 pobj own,on
R2660 T3959 T3957 pobj level,of
R2661 T3960 T3959 compound wt,level
R2662 T3961 T3942 auxpass was,observed
R2663 T3962 T3942 prep in,observed
R2664 T3963 T3964 amod hemizygous,cells
R2665 T3964 T3962 pobj cells,in
R2666 T3965 T3966 compound XpdTTD,KO
R2667 T3966 T3964 compound KO,cells
R2668 T3967 T3966 punct /,KO
R2669 T3968 T3942 punct .,observed
R267 T587 T567 punct .,defined
R2670 T3970 T3971 advcl Consistent,was
R2671 T3972 T3970 prep with,Consistent
R2672 T3973 T3974 amod low,levels
R2673 T3974 T3972 pobj levels,with
R2674 T3975 T3976 compound mRNA,expression
R2675 T3976 T3974 compound expression,levels
R2676 T3977 T3971 punct ", ",was
R2677 T3978 T3979 preconj neither,allele
R2678 T3979 T3971 nsubj allele,was
R2679 T3980 T3981 det the,Xpd†XPCS
R268 T589 T590 prep Despite,considered
R2680 T3981 T3979 nmod Xpd†XPCS,allele
R2681 T3982 T3981 cc nor,Xpd†XPCS
R2682 T3983 T3984 det the,Xpd†XP
R2683 T3984 T3981 conj Xpd†XP,Xpd†XPCS
R2684 T3985 T3971 acomp able,was
R2685 T3986 T3987 aux to,restore
R2686 T3987 T3985 xcomp restore,able
R2687 T3988 T3989 compound TFIIH,abundance
R2688 T3989 T3987 dobj abundance,restore
R2689 T3990 T3987 prep to,restore
R269 T591 T592 poss its,universality
R2690 T3991 T3992 compound wt,levels
R2691 T3992 T3990 pobj levels,to
R2692 T3993 T3987 prep in,restore
R2693 T3994 T3995 compound XpdTTD,cells
R2694 T3995 T3993 pobj cells,in
R2695 T3996 T3995 compound compound,cells
R2696 T3997 T3995 compound heterozygote,cells
R2697 T3998 T3999 punct (,4E
R2698 T3999 T3971 parataxis 4E,was
R2699 T4000 T3999 compound Figure,4E
R270 T592 T589 pobj universality,Despite
R2700 T4001 T3999 cc and,4E
R2701 T4002 T3999 conj 4F,4E
R2702 T4003 T3999 punct ),4E
R2703 T4004 T3971 punct .,was
R2704 T4006 T4007 advmod Thus,were
R2705 T4008 T4007 punct ", ",were
R2706 T4009 T4010 det the,survival
R2707 T4010 T4007 nsubj survival,were
R2708 T4011 T4010 amod improved,survival
R2709 T4012 T4010 compound UV,survival
R271 T593 T592 amod near,universality
R2710 T4013 T4010 acl observed,survival
R2711 T4014 T4013 prep in,observed
R2712 T4015 T4016 compound compound,cells
R2713 T4016 T4014 pobj cells,in
R2714 T4017 T4016 compound heterozygote,cells
R2715 T4018 T4019 punct (,4A
R2716 T4019 T4013 parataxis 4A,observed
R2717 T4020 T4019 compound Figure,4A
R2718 T4021 T4019 punct ),4A
R2719 T4022 T4013 cc and,observed
R272 T594 T592 prep in,universality
R2720 T4023 T4024 advmod likely,rescue
R2721 T4024 T4013 conj rescue,observed
R2722 T4025 T4024 det the,rescue
R2723 T4026 T4024 prep of,rescue
R2724 T4027 T4028 compound TTD,symptoms
R2725 T4028 T4026 pobj symptoms,of
R2726 T4029 T4028 compound progeroid,symptoms
R2727 T4030 T4031 punct (,Figure
R2728 T4031 T4024 parataxis Figure,rescue
R2729 T4032 T4031 nummod 3,Figure
R273 T595 T596 amod lower,organisms
R2730 T4033 T4031 punct ),Figure
R2731 T4034 T4007 neg not,were
R2732 T4035 T4007 prep due,were
R2733 T4036 T4035 pcomp to,due
R2734 T4037 T4035 pobj normalisation,due
R2735 T4038 T4037 prep of,normalisation
R2736 T4039 T4040 compound TFIIH,levels
R2737 T4040 T4038 pobj levels,of
R2738 T4041 T4007 punct ", ",were
R2739 T4042 T4007 advcl suggesting,were
R274 T596 T594 pobj organisms,in
R2740 T4043 T4044 advmod a,qualitative
R2741 T4044 T4045 amod qualitative,effect
R2742 T4045 T4042 dobj effect,suggesting
R2743 T4046 T4047 advmod rather,than
R2744 T4047 T4044 cc than,qualitative
R2745 T4048 T4049 advmod a,quantitative
R2746 T4049 T4044 conj quantitative,qualitative
R2747 T4050 T4045 prep on,effect
R2748 T4051 T4052 det these,phenotypes
R2749 T4052 T4050 pobj phenotypes,on
R275 T597 T598 punct [,1
R2750 T4053 T4054 advmod in,vivo
R2751 T4054 T4045 advmod vivo,effect
R2752 T4055 T4007 punct .,were
R2753 T4057 T4058 prep In,affect
R2754 T4059 T4057 pobj contrast,In
R2755 T4060 T4058 punct ", ",affect
R2756 T4061 T4062 det the,level
R2757 T4062 T4058 nsubj level,affect
R2758 T4063 T4062 prep of,level
R2759 T4064 T4065 compound XPCS,expression
R276 T598 T596 parataxis 1,organisms
R2760 T4065 T4063 pobj expression,of
R2761 T4066 T4065 compound mRNA,expression
R2762 T4067 T4058 aux did,affect
R2763 T4068 T4069 det the,ability
R2764 T4069 T4058 dobj ability,affect
R2765 T4070 T4069 prep of,ability
R2766 T4071 T4072 det the,protein
R2767 T4072 T4070 pobj protein,of
R2768 T4073 T4072 amod encoded,protein
R2769 T4074 T4072 punct (,protein
R277 T599 T598 punct ],1
R2770 T4075 T4072 appos XPDG602D,protein
R2771 T4076 T4069 punct ),ability
R2772 T4077 T4078 aux to,restore
R2773 T4078 T4069 acl restore,ability
R2774 T4079 T4080 det the,phenotype
R2775 T4080 T4078 dobj phenotype,restore
R2776 T4081 T4080 compound TTD,phenotype
R2777 T4082 T4080 compound hair,phenotype
R2778 T4083 T4078 prep to,restore
R2779 T4084 T4083 amod normal,to
R278 T600 T590 punct ", ",considered
R2780 T4085 T4058 punct .,affect
R2781 T4087 T4088 advmod Notably,had
R2782 T4089 T4088 punct ", ",had
R2783 T4090 T4091 compound XpdTTD, †XPCS
R2784 T4091 T4093 compound  †XPCS,animals
R2785 T4092 T4091 punct /, †XPCS
R2786 T4093 T4088 nsubj animals,had
R2787 T4094 T4095 det a,phenotype
R2788 T4095 T4088 dobj phenotype,had
R2789 T4096 T4095 amod partial,phenotype
R279 T601 T602 poss its,potential
R2790 T4097 T4095 compound TTD,phenotype
R2791 T4098 T4095 compound hair,phenotype
R2792 T4099 T4095 punct ", ",phenotype
R2793 T4100 T4095 acl correlating,phenotype
R2794 T4101 T4100 prep with,correlating
R2795 T4102 T4103 amod low,levels
R2796 T4103 T4101 pobj levels,with
R2797 T4104 T4103 prep of,levels
R2798 T4105 T4106 compound Xpd†XPCS,expression
R2799 T4106 T4104 pobj expression,of
R280 T602 T590 nsubjpass potential,considered
R2800 T4107 T4088 punct ", ",had
R2801 T4108 T4109 mark whereas,had
R2802 T4109 T4088 advcl had,had
R2803 T4110 T4111 compound XpdTTD,XPCS
R2804 T4111 T4113 compound XPCS,animals
R2805 T4112 T4111 punct /,XPCS
R2806 T4113 T4109 nsubj animals,had
R2807 T4114 T4115 compound wt,hair
R2808 T4115 T4109 dobj hair,had
R2809 T4116 T4115 punct ", ",hair
R281 T603 T604 aux to,contribute
R2810 T4117 T4115 acl correlating,hair
R2811 T4118 T4117 prep with,correlating
R2812 T4119 T4120 amod normal,levels
R2813 T4120 T4118 pobj levels,with
R2814 T4121 T4120 compound expression,levels
R2815 T4122 T4120 prep from,levels
R2816 T4123 T4124 det the,allele
R2817 T4124 T4122 pobj allele,from
R2818 T4125 T4124 amod viable,allele
R2819 T4126 T4124 compound XpdXPCS,allele
R282 T604 T602 acl contribute,potential
R2820 T4127 T4128 punct (,Table
R2821 T4128 T4088 parataxis Table,had
R2822 T4129 T4128 nummod 2,Table
R2823 T4130 T4128 cc and,Table
R2824 T4131 T4132 amod unpublished,data
R2825 T4132 T4128 conj data,Table
R2826 T4133 T4128 punct ),Table
R2827 T4134 T4088 punct .,had
R2828 T4136 T4137 advmod Thus,affected
R2829 T4138 T4137 punct ", ",affected
R283 T605 T604 prep to,contribute
R2830 T4139 T4140 det the,range
R2831 T4140 T4137 nsubj range,affected
R2832 T4141 T4140 prep of,range
R2833 T4142 T4143 compound expression,levels
R2834 T4143 T4141 pobj levels,of
R2835 T4144 T4140 prep from,range
R2836 T4145 T4146 det these,alleles
R2837 T4146 T4144 pobj alleles,from
R2838 T4147 T4146 nummod two,alleles
R2839 T4148 T4146 amod mutant,alleles
R284 T606 T607 amod clinical,heterogeneity
R2840 T4149 T4150 poss their,ability
R2841 T4150 T4137 dobj ability,affected
R2842 T4151 T4152 aux to,complement
R2843 T4152 T4150 acl complement,ability
R2844 T4153 T4154 det some,phenotypes
R2845 T4154 T4152 dobj phenotypes,complement
R2846 T4155 T4156 punct (,hair
R2847 T4156 T4154 parataxis hair,phenotypes
R2848 T4157 T4156 punct ),hair
R2849 T4158 T4137 punct .,affected
R285 T607 T605 pobj heterogeneity,to
R2850 T4160 T4161 det An,overview
R2851 T4161 T4162 nsubjpass overview,presented
R2852 T4163 T4161 prep of,overview
R2853 T4164 T4165 det the,relationships
R2854 T4165 T4163 pobj relationships,of
R2855 T4166 T4165 amod functional,relationships
R2856 T4167 T4165 prep between,relationships
R2857 T4168 T4169 compound Xpd,alleles
R2858 T4169 T4167 pobj alleles,between
R2859 T4170 T4169 punct ", ",alleles
R286 T608 T607 prep in,heterogeneity
R2860 T4171 T4169 conj phenotypes,alleles
R2861 T4172 T4171 punct ", ",phenotypes
R2862 T4173 T4171 cc and,phenotypes
R2863 T4174 T4175 det the,function
R2864 T4175 T4171 conj function,phenotypes
R2865 T4176 T4175 amod presumed,function
R2866 T4177 T4175 amod underlying,function
R2867 T4178 T4175 compound TFIIH,function
R2868 T4179 T4165 prep in,relationships
R2869 T4180 T4179 pobj mice,in
R287 T609 T610 amod human,disease
R2870 T4181 T4180 cc and,mice
R2871 T4182 T4180 conj cells,mice
R2872 T4183 T4162 auxpass is,presented
R2873 T4184 T4162 prep in,presented
R2874 T4185 T4184 pobj Table,in
R2875 T4186 T4185 nummod 2,Table
R2876 T4187 T4162 punct .,presented
R2877 T4260 T4259 prep of,Dissection
R2878 T4261 T4262 amod Biallelic,Effects
R2879 T4262 T4260 pobj Effects,of
R288 T610 T608 pobj disease,in
R2880 T4263 T4259 prep from,Dissection
R2881 T4264 T4265 amod other,Determinants
R2882 T4265 T4263 pobj Determinants,from
R2883 T4266 T4265 prep of,Determinants
R2884 T4267 T4266 pobj Phenotype,of
R2885 T4269 T4270 mark Although,postulated
R2886 T4270 T4293 advcl postulated,been
R2887 T4271 T4272 amod phenotypic,consequences
R2888 T4272 T4270 nsubjpass consequences,postulated
R2889 T4273 T4272 punct ", ",consequences
R289 T611 T590 auxpass is,considered
R2890 T4274 T4272 acl referred,consequences
R2891 T4275 T4274 prep to,referred
R2892 T4276 T4274 advmod here,referred
R2893 T4277 T4274 prep as,referred
R2894 T4278 T4279 amod biallelic,effects
R2895 T4279 T4277 pobj effects,as
R2896 T4280 T4272 punct ", ",consequences
R2897 T4281 T4272 acl resulting,consequences
R2898 T4282 T4281 prep from,resulting
R2899 T4283 T4284 nummod two,alleles
R290 T612 T590 advmod seldom,considered
R2900 T4284 T4282 pobj alleles,from
R2901 T4285 T4284 amod different,alleles
R2902 T4286 T4284 amod mutant,alleles
R2903 T4287 T4284 prep in,alleles
R2904 T4288 T4289 compound compound,patients
R2905 T4289 T4287 pobj patients,in
R2906 T4290 T4289 compound heterozygote,patients
R2907 T4291 T4270 aux have,postulated
R2908 T4292 T4270 auxpass been,postulated
R2909 T4294 T4293 punct ", ",been
R291 T613 T590 punct .,considered
R2910 T4295 T4296 amod such,effects
R2911 T4296 T4293 nsubj effects,been
R2912 T4297 T4293 aux have,been
R2913 T4298 T4293 advmod historically,been
R2914 T4299 T4293 acomp difficult,been
R2915 T4300 T4301 aux to,distinguish
R2916 T4301 T4299 xcomp distinguish,difficult
R2917 T4302 T4301 prep from,distinguish
R2918 T4303 T4304 det the,influence
R2919 T4304 T4302 pobj influence,from
R292 T615 T616 nsubjpass Evidence,limited
R2920 T4305 T4304 prep of,influence
R2921 T4306 T4305 pobj environment,of
R2922 T4307 T4306 cc and,environment
R2923 T4308 T4309 amod genetic,background
R2924 T4309 T4306 conj background,environment
R2925 T4310 T4293 punct .,been
R2926 T4312 T4313 nsubj We,used
R2927 T4314 T4315 det a,system
R2928 T4315 T4313 dobj system,used
R2929 T4316 T4317 advmod genetically,defined
R293 T617 T615 prep of,Evidence
R2930 T4317 T4315 amod defined,system
R2931 T4318 T4315 amod mammalian,system
R2932 T4319 T4315 compound model,system
R2933 T4320 T4313 prep under,used
R2934 T4321 T4322 amod controlled,conditions
R2935 T4322 T4320 pobj conditions,under
R2936 T4323 T4322 amod environmental,conditions
R2937 T4324 T4325 aux to,reveal
R2938 T4325 T4313 advcl reveal,used
R2939 T4326 T4327 amod phenotypic,effects
R294 T618 T619 amod interallelic,complementation
R2940 T4327 T4325 dobj effects,reveal
R2941 T4328 T4327 amod attributable,effects
R2942 T4329 T4330 advmod specifically,to
R2943 T4330 T4328 prep to,attributable
R2944 T4331 T4330 pobj combinations,to
R2945 T4332 T4331 prep of,combinations
R2946 T4333 T4334 advmod differentially,mutated
R2947 T4334 T4335 amod mutated,alleles
R2948 T4335 T4332 pobj alleles,of
R2949 T4336 T4335 compound Xpd,alleles
R295 T619 T617 pobj complementation,of
R2950 T4337 T4313 punct .,used
R2951 T4339 T4340 det The,effects
R2952 T4340 T4343 nsubj effects,were
R2953 T4341 T4340 amod observed,effects
R2954 T4342 T4340 amod biallelic,effects
R2955 T4344 T4343 prep of,were
R2956 T4345 T4346 nummod three,types
R2957 T4346 T4344 pobj types,of
R2958 T4347 T4346 amod general,types
R2959 T4348 T4343 punct .,were
R296 T620 T619 prep at,complementation
R2960 T4350 T4351 prep In,determined
R2961 T4352 T4353 det the,first
R2962 T4353 T4350 pobj first,In
R2963 T4354 T4351 punct ", ",determined
R2964 T4355 T4356 det the,allele
R2965 T4356 T4351 nsubj allele,determined
R2966 T4357 T4356 acl associated,allele
R2967 T4358 T4357 prep in,associated
R2968 T4359 T4360 det a,state
R2969 T4360 T4358 pobj state,in
R297 T621 T622 advmod clinically,relevant
R2970 T4361 T4360 amod homozygous,state
R2971 T4362 T4357 prep with,associated
R2972 T4363 T4364 det a,phenotype
R2973 T4364 T4362 pobj phenotype,with
R2974 T4365 T4366 advmod closer,to
R2975 T4366 T4364 amod to,phenotype
R2976 T4367 T4366 pobj wt,to
R2977 T4368 T4351 advmod singularly,determined
R2978 T4369 T4370 det the,outcome
R2979 T4370 T4351 dobj outcome,determined
R298 T622 T623 amod relevant,loci
R2980 T4371 T4370 amod phenotypic,outcome
R2981 T4372 T4351 punct ", ",determined
R2982 T4373 T4374 det a,phenomenon
R2983 T4374 T4351 npadvmod phenomenon,determined
R2984 T4375 T4376 advmod widely,known
R2985 T4376 T4374 acl known,phenomenon
R2986 T4377 T4376 prep in,known
R2987 T4378 T4379 amod human,disease
R2988 T4379 T4377 pobj disease,in
R2989 T4380 T4379 amod recessive,disease
R299 T623 T620 pobj loci,at
R2990 T4381 T4351 punct .,determined
R2991 T4383 T4384 mark Because,functioned
R2992 T4384 T4388 advcl functioned,call
R2993 T4385 T4386 det these,alleles
R2994 T4386 T4384 nsubj alleles,functioned
R2995 T4387 T4386 compound Xpd,alleles
R2996 T4389 T4384 prep at,functioned
R2997 T4390 T4389 cc or,at
R2998 T4391 T4389 conj near,at
R2999 T4392 T4393 compound wt,levels
R300 T624 T616 auxpass is,limited
R3000 T4393 T4391 pobj levels,near
R3001 T4394 T4384 prep with,functioned
R3002 T4395 T4394 pobj respect,with
R3003 T4396 T4395 prep to,respect
R3004 T4397 T4398 det a,function
R3005 T4398 T4396 pobj function,to
R3006 T4399 T4398 amod particular,function
R3007 T4400 T4388 punct ", ",call
R3008 T4401 T4388 nsubj we,call
R3009 T4402 T4403 det these,effects
R301 T625 T616 prep to,limited
R3010 T4403 T4388 dobj effects,call
R3011 T4404 T4388 punct “,call
R3012 T4405 T4388 oprd dominant,call
R3013 T4406 T4388 punct ”,call
R3014 T4407 T4388 punct .,call
R3015 T4409 T4410 amod Such,alleles
R3016 T4410 T4411 nsubjpass alleles,referred
R3017 T4412 T4411 aux can,referred
R3018 T4413 T4411 advmod also,referred
R3019 T4414 T4411 auxpass be,referred
R302 T626 T627 amod biochemical,studies
R3020 T4415 T4411 prep to,referred
R3021 T4416 T4411 prep as,referred
R3022 T4417 T4418 punct “,alleles
R3023 T4418 T4416 pobj alleles,as
R3024 T4419 T4418 nmod separation,alleles
R3025 T4420 T4419 prep of,separation
R3026 T4421 T4420 pobj function,of
R3027 T4422 T4418 punct ”,alleles
R3028 T4423 T4411 punct ", ",referred
R3029 T4424 T4425 mark because,allow
R303 T627 T625 pobj studies,to
R3030 T4425 T4411 advcl allow,referred
R3031 T4426 T4425 nsubj they,allow
R3032 T4427 T4425 dobj dissection,allow
R3033 T4428 T4427 prep of,dissection
R3034 T4429 T4430 det the,roles
R3035 T4430 T4428 pobj roles,of
R3036 T4431 T4430 prep of,roles
R3037 T4432 T4433 amod multifunctional,proteins
R3038 T4433 T4431 pobj proteins,of
R3039 T4434 T4425 prep in,allow
R304 T628 T626 cc and,biochemical
R3040 T4435 T4436 amod specific,phenotypes
R3041 T4436 T4434 pobj phenotypes,in
R3042 T4437 T4411 punct .,referred
R3043 T4439 T4440 advmod Secondly,was
R3044 T4441 T4440 punct ", ",was
R3045 T4442 T4440 dep highlighting,was
R3046 T4443 T4444 det the,relevance
R3047 T4444 T4442 dobj relevance,highlighting
R3048 T4445 T4444 amod potential,relevance
R3049 T4446 T4444 prep of,relevance
R305 T629 T630 npadvmod cell,based
R3050 T4447 T4448 amod current,findings
R3051 T4448 T4446 pobj findings,of
R3052 T4449 T4444 prep to,relevance
R3053 T4450 T4451 det all,organisms
R3054 T4451 T4449 pobj organisms,to
R3055 T4452 T4451 amod diploid,organisms
R3056 T4453 T4451 prep including,organisms
R3057 T4454 T4453 pobj humans,including
R3058 T4455 T4456 det the,observation
R3059 T4456 T4440 nsubj observation,was
R306 T630 T626 conj based,biochemical
R3060 T4457 T4458 mark that,shift
R3061 T4458 T4456 acl shift,observation
R3062 T4459 T4458 prep in,shift
R3063 T4460 T4461 nummod one,animal
R3064 T4461 T4459 pobj animal,in
R3065 T4462 T4461 nmod compound,animal
R3066 T4463 T4461 amod heterozygous,animal
R3067 T4464 T4458 punct ", ",shift
R3068 T4465 T4466 det the,relationship
R3069 T4466 T4458 nsubj relationship,shift
R307 T631 T630 punct -,based
R3070 T4467 T4466 nmod Xpd,relationship
R3071 T4468 T4466 amod allelic,relationship
R3072 T4469 T4458 aux could,shift
R3073 T4470 T4458 prep from,shift
R3074 T4471 T4472 amod A dominant,a recessive
R3075 T4472 T4470 pobj a recessive,from
R3076 T4473 T4472 punct |,a recessive
R3077 T4474 T4470 prep to,from
R3078 T4475 T4476 amod A recessive,a dominant
R3079 T4476 T4474 pobj a dominant,to
R308 T632 T627 prep of,studies
R3080 T4477 T4476 punct |,a dominant
R3081 T4478 T4458 prep with,shift
R3082 T4479 T4478 pobj respect,with
R3083 T4480 T4479 prep to,respect
R3084 T4481 T4482 amod different,phenotypes
R3085 T4482 T4480 pobj phenotypes,to
R3086 T4483 T4458 prep in,shift
R3087 T4484 T4485 det a,manner
R3088 T4485 T4483 pobj manner,in
R3089 T4486 T4487 npadvmod time,dependent
R309 T633 T634 det a,handful
R3090 T4487 T4485 amod dependent,manner
R3091 T4488 T4487 punct -,dependent
R3092 T4489 T4487 cc and,dependent
R3093 T4490 T4491 npadvmod tissue,specific
R3094 T4491 T4487 conj specific,dependent
R3095 T4492 T4491 punct -,specific
R3096 T4493 T4494 punct (,see
R3097 T4494 T4458 parataxis see,shift
R3098 T4495 T4496 advmod below,Table
R3099 T4496 T4494 dobj Table,see
R310 T634 T632 pobj handful,of
R3100 T4497 T4496 cc and,Table
R3101 T4498 T4496 nummod 2,Table
R3102 T4499 T4494 punct ),see
R3103 T4500 T4440 punct .,was
R3104 T4502 T4503 prep In,produced
R3105 T4504 T4505 det the,type
R3106 T4505 T4502 pobj type,In
R3107 T4506 T4505 amod third,type
R3108 T4507 T4505 prep of,type
R3109 T4508 T4509 amod biallelic,effect
R311 T635 T634 prep of,handful
R3110 T4509 T4507 pobj effect,of
R3111 T4510 T4505 punct ", ",type
R3112 T4511 T4505 acl known,type
R3113 T4512 T4511 prep as,known
R3114 T4513 T4514 amod interallelic,complementation
R3115 T4514 T4512 pobj complementation,as
R3116 T4515 T4503 punct ", ",produced
R3117 T4516 T4517 nummod two,alleles
R3118 T4517 T4503 nsubj alleles,produced
R3119 T4518 T4517 amod mutant,alleles
R312 T636 T637 amod metabolic,disorders
R3120 T4519 T4520 det a,phenotype
R3121 T4520 T4503 dobj phenotype,produced
R3122 T4521 T4522 advmod closer,to
R3123 T4522 T4520 amod to,phenotype
R3124 T4523 T4522 pobj wt,to
R3125 T4524 T4525 mark than,alone
R3126 T4525 T4522 advcl alone,to
R3127 T4526 T4525 nsubj either,alone
R3128 T4527 T4525 aux could,alone
R3129 T4528 T4525 prep in,alone
R313 T637 T635 pobj disorders,of
R3130 T4529 T4530 det a,state
R3131 T4530 T4528 pobj state,in
R3132 T4531 T4532 advmod homo,hemizygous
R3133 T4532 T4530 amod hemizygous,state
R3134 T4533 T4532 punct -,hemizygous
R3135 T4534 T4532 cc or,hemizygous
R3136 T4535 T4503 punct .,produced
R3137 T4537 T4538 mark As,summarised
R3138 T4538 T4539 advcl summarised,observed
R3139 T4540 T4538 prep in,summarised
R314 T638 T637 prep with,disorders
R3140 T4541 T4540 pobj Table,in
R3141 T4542 T4541 nummod 2,Table
R3142 T4543 T4539 punct ", ",observed
R3143 T4544 T4539 nsubjpass examples,observed
R3144 T4545 T4544 prep of,examples
R3145 T4546 T4547 det all,types
R3146 T4547 T4545 pobj types,of
R3147 T4548 T4547 prep of,types
R3148 T4549 T4550 amod biallelic,effects
R3149 T4550 T4548 pobj effects,of
R315 T639 T638 pobj defects,with
R3150 T4551 T4539 auxpass were,observed
R3151 T4552 T4539 prep in,observed
R3152 T4553 T4554 det a,variety
R3153 T4554 T4552 pobj variety,in
R3154 T4555 T4554 prep of,variety
R3155 T4556 T4557 npadvmod Xpd,associated
R3156 T4557 T4559 amod associated,phenotypes
R3157 T4558 T4557 punct -,associated
R3158 T4559 T4555 pobj phenotypes,of
R3159 T4560 T4554 punct ", ",variety
R316 T640 T639 prep in,defects
R3160 T4561 T4554 acl ranging,variety
R3161 T4562 T4561 prep from,ranging
R3162 T4563 T4564 amod brittle,hair
R3163 T4564 T4562 pobj hair,from
R3164 T4565 T4562 prep to,from
R3165 T4566 T4567 amod segmental,progeria
R3166 T4567 T4565 pobj progeria,to
R3167 T4568 T4539 punct .,observed
R317 T641 T640 pobj enzymes,in
R318 T642 T641 prep including,enzymes
R3180 T4806 T4805 prep in,TFIIH
R3181 T4807 T4806 pobj Transcription,in
R3182 T4808 T4807 cc and,Transcription
R3183 T4809 T4807 conj Repair,Transcription
R3184 T4810 T4805 punct : ,TFIIH
R3185 T4811 T4805 appos Mechanisms,TFIIH
R3186 T4812 T4811 prep of,Mechanisms
R3187 T4813 T4814 compound XPD,Pleiotropy
R3188 T4814 T4812 pobj Pleiotropy,of
R3189 T4815 T4814 compound Disease,Pleiotropy
R319 T643 T644 compound propinyl,CoA
R3190 T4817 T4818 nsubj We,observed
R3191 T4819 T4818 dobj differences,observed
R3192 T4820 T4819 prep in,differences
R3193 T4821 T4822 det the,ability
R3194 T4822 T4820 pobj ability,in
R3195 T4823 T4822 prep of,ability
R3196 T4824 T4823 pobj XpdTTD,of
R3197 T4825 T4824 cc versus,XpdTTD
R3198 T4826 T4827 amod homozygous,alleles
R3199 T4827 T4824 conj alleles,XpdTTD
R320 T644 T646 compound CoA,carboxylase
R3200 T4828 T4827 amod lethal,alleles
R3201 T4829 T4827 nmod Xpd†XPCS,alleles
R3202 T4830 T4829 cc and,Xpd†XPCS
R3203 T4831 T4829 conj Xpd†XP,Xpd†XPCS
R3204 T4832 T4833 aux to,function
R3205 T4833 T4822 acl function,ability
R3206 T4834 T4833 prep in,function
R3207 T4835 T4836 nummod two,phenotypes
R3208 T4836 T4834 pobj phenotypes,in
R3209 T4837 T4838 npadvmod transcription,related
R321 T645 T644 punct -,CoA
R3210 T4838 T4836 amod related,phenotypes
R3211 T4839 T4838 punct -,related
R3212 T4840 T4836 acl separated,phenotypes
R3213 T4841 T4840 prep in,separated
R3214 T4842 T4843 det the,organism
R3215 T4843 T4841 pobj organism,in
R3216 T4844 T4840 prep by,separated
R3217 T4845 T4846 preconj both,time
R3218 T4846 T4844 pobj time,by
R3219 T4847 T4846 cc and,time
R322 T646 T642 pobj carboxylase,including
R3220 T4848 T4846 conj space,time
R3221 T4849 T4819 punct : ,differences
R3222 T4850 T4851 amod embryonic,lethality
R3223 T4851 T4819 appos lethality,differences
R3224 T4852 T4851 cc and,lethality
R3225 T4853 T4854 amod terminal,differentiation
R3226 T4854 T4851 conj differentiation,lethality
R3227 T4855 T4854 prep of,differentiation
R3228 T4856 T4857 amod enucleating,skin
R3229 T4857 T4855 pobj skin,of
R323 T647 T648 punct [,2
R3230 T4858 T4857 cc and,skin
R3231 T4859 T4860 compound blood,cells
R3232 T4860 T4857 conj cells,skin
R3233 T4861 T4818 punct .,observed
R3234 T4863 T4864 det The,lethality
R3235 T4864 T4869 nsubj lethality,reflects
R3236 T4865 T4866 nmod preblastocyst,stage
R3237 T4866 T4864 nmod stage,lethality
R3238 T4867 T4866 punct -,stage
R3239 T4868 T4864 amod homozygous,lethality
R324 T648 T646 parataxis 2,carboxylase
R3240 T4870 T4864 acl shared,lethality
R3241 T4871 T4870 agent by,shared
R3242 T4872 T4873 det the,alleles
R3243 T4873 T4871 pobj alleles,by
R3244 T4874 T4873 nmod XpdKO,alleles
R3245 T4875 T4874 punct ", ",XpdKO
R3246 T4876 T4874 conj Xpd†XPCS,XpdKO
R3247 T4877 T4876 punct ", ",Xpd†XPCS
R3248 T4878 T4876 cc and,Xpd†XPCS
R3249 T4879 T4876 conj Xpd†XP,Xpd†XPCS
R325 T649 T648 punct ],2
R3250 T4880 T4881 advmod most,likely
R3251 T4881 T4869 advmod likely,reflects
R3252 T4882 T4883 det a,defect
R3253 T4883 T4869 dobj defect,reflects
R3254 T4884 T4883 prep in,defect
R3255 T4885 T4886 amod basal,transcription
R3256 T4886 T4884 pobj transcription,in
R3257 T4887 T4888 dep that,is
R3258 T4888 T4883 relcl is,defect
R3259 T4889 T4888 acomp incompatible,is
R326 T650 T646 punct ", ",carboxylase
R3260 T4890 T4889 prep with,incompatible
R3261 T4891 T4890 pobj life,with
R3262 T4892 T4869 punct .,reflects
R3263 T4894 T4895 prep In,rescued
R3264 T4896 T4897 nmod XpdTTD, †XPCS
R3265 T4897 T4899 nmod  †XPCS,mice
R3266 T4898 T4897 punct /, †XPCS
R3267 T4899 T4894 pobj mice,In
R3268 T4900 T4897 cc and, †XPCS
R3269 T4901 T4902 compound XpdTTD, †XP
R327 T651 T652 compound argininosuccinate,lyase
R3270 T4902 T4897 conj  †XP, †XPCS
R3271 T4903 T4902 punct /, †XP
R3272 T4904 T4899 nmod compound,mice
R3273 T4905 T4899 amod heterozygous,mice
R3274 T4906 T4895 punct ", ",rescued
R3275 T4907 T4908 amod embryonic,lethality
R3276 T4908 T4895 nsubjpass lethality,rescued
R3277 T4909 T4895 auxpass was,rescued
R3278 T4910 T4895 advmod fully,rescued
R3279 T4911 T4895 agent by,rescued
R328 T652 T646 conj lyase,carboxylase
R3280 T4912 T4913 det the,allele
R3281 T4913 T4911 pobj allele,by
R3282 T4914 T4913 compound XpdTTD,allele
R3283 T4915 T4895 punct .,rescued
R3284 T4917 T4918 mark Because,rescued
R3285 T4918 T4924 advcl rescued,considered
R3286 T4919 T4920 amod embryonic,lethality
R3287 T4920 T4918 nsubjpass lethality,rescued
R3288 T4921 T4918 auxpass was,rescued
R3289 T4922 T4918 advmod also,rescued
R329 T653 T654 punct [,3
R3290 T4923 T4918 advmod fully,rescued
R3291 T4925 T4918 prep in,rescued
R3292 T4926 T4927 nmod XpdTTD,KO
R3293 T4927 T4929 nmod KO,mice
R3294 T4928 T4927 punct /,KO
R3295 T4929 T4925 pobj mice,in
R3296 T4930 T4929 amod hemizygous,mice
R3297 T4931 T4924 punct ", ",considered
R3298 T4932 T4933 det the,allele
R3299 T4933 T4924 nsubjpass allele,considered
R330 T654 T652 parataxis 3,lyase
R3300 T4934 T4933 compound XpdTTD,allele
R3301 T4935 T4924 aux can,considered
R3302 T4936 T4924 auxpass be,considered
R3303 T4937 T4924 prep as,considered
R3304 T4938 T4937 pobj wt,as
R3305 T4939 T4938 cc and,wt
R3306 T4940 T4941 advmod thus,dominant
R3307 T4941 T4938 conj dominant,wt
R3308 T4942 T4941 prep to,dominant
R3309 T4943 T4942 pobj each,to
R331 T655 T654 punct ],3
R3310 T4944 T4943 prep of,each
R3311 T4945 T4946 det the,alleles
R3312 T4946 T4944 pobj alleles,of
R3313 T4947 T4946 amod homozygous,alleles
R3314 T4948 T4946 amod lethal,alleles
R3315 T4949 T4950 punct (,XpdKO
R3316 T4950 T4946 parataxis XpdKO,alleles
R3317 T4951 T4950 punct ", ",XpdKO
R3318 T4952 T4950 conj Xpd†XPCS,XpdKO
R3319 T4953 T4952 punct ", ",Xpd†XPCS
R332 T656 T652 punct ", ",lyase
R3320 T4954 T4952 cc and,Xpd†XPCS
R3321 T4955 T4952 conj Xpd†XP,Xpd†XPCS
R3322 T4956 T4950 punct ),XpdKO
R3323 T4957 T4941 prep with,dominant
R3324 T4958 T4957 pobj respect,with
R3325 T4959 T4958 prep to,respect
R3326 T4960 T4961 det this,phenotype
R3327 T4961 T4959 pobj phenotype,to
R3328 T4962 T4961 amod particular,phenotype
R3329 T4963 T4964 punct (,Table
R333 T657 T658 nmod galactose,phosphate
R3330 T4964 T4924 parataxis Table,considered
R3331 T4965 T4964 nummod 2,Table
R3332 T4966 T4964 punct ),Table
R3333 T4967 T4924 punct .,considered
R3334 T4969 T4970 npadvmod TTD,specific
R3335 T4970 T4972 amod specific,features
R3336 T4971 T4970 punct -,specific
R3337 T4972 T4976 nsubjpass features,thought
R3338 T4973 T4972 amod cutaneous,features
R3339 T4974 T4973 cc and,cutaneous
R334 T658 T662 compound phosphate,uridylyltransferase
R3340 T4975 T4973 conj anaemic,cutaneous
R3341 T4977 T4976 punct ", ",thought
R3342 T4978 T4976 prep on,thought
R3343 T4979 T4980 det the,hand
R3344 T4980 T4978 pobj hand,on
R3345 T4981 T4980 amod other,hand
R3346 T4982 T4976 punct ", ",thought
R3347 T4983 T4976 auxpass are,thought
R3348 T4984 T4985 aux to,result
R3349 T4985 T4976 xcomp result,thought
R335 T659 T658 punct -,phosphate
R3350 T4986 T4985 prep from,result
R3351 T4987 T4988 det a,kind
R3352 T4988 T4986 pobj kind,from
R3353 T4989 T4988 amod specific,kind
R3354 T4990 T4988 prep of,kind
R3355 T4991 T4992 amod transcriptional,insufficiency
R3356 T4992 T4990 pobj insufficiency,of
R3357 T4993 T4988 acl caused,kind
R3358 T4994 T4993 agent by,caused
R3359 T4995 T4994 pobj depletion,by
R336 T660 T658 nummod 1,phosphate
R3360 T4996 T4995 prep of,depletion
R3361 T4997 T4998 amod unstable,TFIIH
R3362 T4998 T4996 pobj TFIIH,of
R3363 T4999 T4995 prep during,depletion
R3364 T5000 T5001 det the,differentiation
R3365 T5001 T4999 pobj differentiation,during
R3366 T5002 T5001 amod terminal,differentiation
R3367 T5003 T5001 prep of,differentiation
R3368 T5004 T5005 nmod skin,cells
R3369 T5005 T5003 pobj cells,of
R337 T661 T658 punct -,phosphate
R3370 T5006 T5004 punct ", ",skin
R3371 T5007 T5008 compound hair,shaft
R3372 T5008 T5004 conj shaft,skin
R3373 T5009 T5008 punct -,shaft
R3374 T5010 T5008 punct ", ",shaft
R3375 T5011 T5008 cc and,shaft
R3376 T5012 T5008 conj blood,shaft
R3377 T5013 T5014 punct [,24
R3378 T5014 T4976 parataxis 24,thought
R3379 T5015 T5014 nummod 16,24
R338 T662 T652 conj uridylyltransferase,lyase
R3380 T5016 T5014 punct ",",24
R3381 T5017 T5014 punct ],24
R3382 T5018 T4976 punct .,thought
R3383 T5020 T5021 prep In,were
R3384 T5022 T5023 nmod compound,mice
R3385 T5023 T5020 pobj mice,In
R3386 T5024 T5023 amod heterozygous,mice
R3387 T5025 T5021 punct ", ",were
R3388 T5026 T5027 det both,alleles
R3389 T5027 T5021 nsubj alleles,were
R339 T663 T664 punct [,4
R3390 T5028 T5027 amod homozygous,alleles
R3391 T5029 T5027 amod lethal,alleles
R3392 T5030 T5027 nmod Xpd†XPCS,alleles
R3393 T5031 T5030 cc and,Xpd†XPCS
R3394 T5032 T5030 conj Xpd†XP,Xpd†XPCS
R3395 T5033 T5021 acomp able,were
R3396 T5034 T5035 aux to,alleviate
R3397 T5035 T5033 xcomp alleviate,able
R3398 T5036 T5037 npadvmod XpdTTD,specific
R3399 T5037 T5039 amod specific,features
R340 T664 T662 parataxis 4,uridylyltransferase
R3400 T5038 T5037 punct -,specific
R3401 T5039 T5035 dobj features,alleviate
R3402 T5040 T5039 amod cutaneous,features
R3403 T5041 T5040 cc and,cutaneous
R3404 T5042 T5040 conj anaemic,cutaneous
R3405 T5043 T5021 cc and,were
R3406 T5044 T5045 aux can,defined
R3407 T5045 T5021 conj defined,were
R3408 T5046 T5045 advmod thus,defined
R3409 T5047 T5045 auxpass be,defined
R341 T665 T664 punct ],4
R3410 T5048 T5045 prep as,defined
R3411 T5049 T5048 amod dominant,as
R3412 T5050 T5045 prep over,defined
R3413 T5051 T5052 det the,allele
R3414 T5052 T5050 pobj allele,over
R3415 T5053 T5052 compound XpdTTD,allele
R3416 T5054 T5045 prep with,defined
R3417 T5055 T5054 pobj respect,with
R3418 T5056 T5055 prep to,respect
R3419 T5057 T5058 det these,phenotypes
R342 T666 T662 punct ", ",uridylyltransferase
R3420 T5058 T5056 pobj phenotypes,to
R3421 T5059 T5021 punct .,were
R3422 T5061 T5062 nsubj We,conclude
R3423 T5063 T5064 mark that,represent
R3424 T5064 T5062 ccomp represent,conclude
R3425 T5065 T5066 det the,defects
R3426 T5066 T5064 nsubj defects,represent
R3427 T5067 T5066 acl leading,defects
R3428 T5068 T5067 prep to,leading
R3429 T5069 T5070 amod embryonic,lethality
R343 T667 T662 cc and,uridylyltransferase
R3430 T5070 T5068 pobj lethality,to
R3431 T5071 T5070 cc and,lethality
R3432 T5072 T5073 amod aberrant,differentiation
R3433 T5073 T5070 conj differentiation,lethality
R3434 T5074 T5073 amod terminal,differentiation
R3435 T5075 T5073 prep of,differentiation
R3436 T5076 T5077 det the,skin
R3437 T5077 T5075 pobj skin,of
R3438 T5078 T5077 punct ", ",skin
R3439 T5079 T5077 conj hair,skin
R344 T668 T669 compound methylmalonyl,mutase
R3440 T5080 T5079 punct ", ",hair
R3441 T5081 T5079 cc and,hair
R3442 T5082 T5079 conj blood,hair
R3443 T5083 T5084 nummod two,deficiencies
R3444 T5084 T5064 dobj deficiencies,represent
R3445 T5085 T5086 advmod qualitatively,different
R3446 T5086 T5084 amod different,deficiencies
R3447 T5087 T5085 cc and,qualitatively
R3448 T5088 T5087 punct /,and
R3449 T5089 T5087 cc or,and
R345 T669 T662 conj mutase,uridylyltransferase
R3450 T5090 T5085 conj quantitatively,qualitatively
R3451 T5091 T5084 amod transcriptional,deficiencies
R3452 T5092 T5062 punct .,conclude
R3453 T5094 T5095 prep During,is
R3454 T5096 T5097 amod early,development
R3455 T5097 T5094 pobj development,During
R3456 T5098 T5097 amod embryonic,development
R3457 T5099 T5095 punct ", ",is
R3458 T5100 T5095 nsubj XpdTTD,is
R3459 T5101 T5095 acomp dominant,is
R346 T670 T669 compound CoA,mutase
R3460 T5102 T5101 prep over,dominant
R3461 T5103 T5104 det the,alleles
R3462 T5104 T5102 pobj alleles,over
R3463 T5105 T5104 nmod Xpd†XPCS,alleles
R3464 T5106 T5105 cc and,Xpd†XPCS
R3465 T5107 T5105 conj Xpd†XP,Xpd†XPCS
R3466 T5108 T5095 punct ", ",is
R3467 T5109 T5110 mark whereas,reversed
R3468 T5110 T5095 advcl reversed,is
R3469 T5111 T5110 advmod later,reversed
R347 T671 T672 punct [,5
R3470 T5112 T5111 prep in,later
R3471 T5113 T5114 det the,ontogenesis
R3472 T5114 T5112 pobj ontogenesis,in
R3473 T5115 T5114 prep of,ontogenesis
R3474 T5116 T5115 pobj skin,of
R3475 T5117 T5116 punct ", ",skin
R3476 T5118 T5119 compound hair,shaft
R3477 T5119 T5116 conj shaft,skin
R3478 T5120 T5119 punct -,shaft
R3479 T5121 T5119 punct ", ",shaft
R348 T672 T669 parataxis 5,mutase
R3480 T5122 T5119 cc and,shaft
R3481 T5123 T5124 compound blood,cells
R3482 T5124 T5119 conj cells,shaft
R3483 T5125 T5110 punct ", ",reversed
R3484 T5126 T5127 det the,situation
R3485 T5127 T5110 nsubjpass situation,reversed
R3486 T5128 T5110 auxpass is,reversed
R3487 T5129 T5095 punct .,is
R3488 T5131 T5132 prep In,imparted
R3489 T5133 T5134 poss its,role
R349 T673 T672 punct ],5
R3490 T5134 T5131 pobj role,In
R3491 T5135 T5134 prep in,role
R3492 T5136 T5137 det the,repair
R3493 T5137 T5135 pobj repair,in
R3494 T5138 T5137 prep of,repair
R3495 T5139 T5140 compound UV,photolesions
R3496 T5140 T5138 pobj photolesions,of
R3497 T5141 T5132 punct ", ",imparted
R3498 T5142 T5143 det the,allele
R3499 T5143 T5132 nsubj allele,imparted
R350 T674 T616 punct .,limited
R3500 T5144 T5143 compound Xpd†XPCS,allele
R3501 T5145 T5146 det a,benefit
R3502 T5146 T5132 dobj benefit,imparted
R3503 T5147 T5146 amod clear,benefit
R3504 T5148 T5146 compound UV,benefit
R3505 T5149 T5146 compound survival,benefit
R3506 T5150 T5146 prep over,benefit
R3507 T5151 T5152 det a,allele
R3508 T5152 T5150 pobj allele,over
R3509 T5153 T5152 amod single,allele
R351 T676 T677 amod Compound,heterozygotes
R3510 T5154 T5152 compound XpdTTD,allele
R3511 T5155 T5152 cc or,allele
R3512 T5156 T5157 nummod two,alleles
R3513 T5157 T5152 conj alleles,allele
R3514 T5158 T5157 compound XpdXPCS,alleles
R3515 T5159 T5146 amod independent,benefit
R3516 T5160 T5159 prep of,independent
R3517 T5161 T5162 compound expression,levels
R3518 T5162 T5160 pobj levels,of
R3519 T5163 T5132 punct ", ",imparted
R352 T677 T678 nsubj heterozygotes,are
R3520 T5164 T5165 dep which,is
R3521 T5165 T5132 advcl is,imparted
R3522 T5166 T5165 acomp consistent,is
R3523 T5167 T5166 prep with,consistent
R3524 T5168 T5169 amod interallelic,complementation
R3525 T5169 T5167 pobj complementation,with
R3526 T5170 T5132 punct .,imparted
R3527 T5172 T5173 advmod However,argues
R3528 T5174 T5173 punct ", ",argues
R3529 T5175 T5176 det the,observation
R353 T679 T678 attr individuals,are
R3530 T5176 T5173 nsubj observation,argues
R3531 T5177 T5178 mark that,improved
R3532 T5178 T5176 acl improved,observation
R3533 T5179 T5180 det no,parameters
R3534 T5180 T5178 nsubjpass parameters,improved
R3535 T5181 T5180 amod other,parameters
R3536 T5182 T5180 amod cellular,parameters
R3537 T5183 T5182 cc or,cellular
R3538 T5184 T5182 conj biochemical,cellular
R3539 T5185 T5186 npadvmod UV,related
R354 T680 T679 acl carrying,individuals
R3540 T5186 T5180 amod related,parameters
R3541 T5187 T5186 punct -,related
R3542 T5188 T5178 auxpass were,improved
R3543 T5189 T5178 prep in,improved
R3544 T5190 T5191 compound XpdTTD, †XPCS
R3545 T5191 T5189 pobj  †XPCS,in
R3546 T5192 T5191 punct /, †XPCS
R3547 T5193 T5173 prep against,argues
R3548 T5194 T5193 pobj complementation,against
R3549 T5195 T5194 prep of,complementation
R355 T681 T682 nummod two,alleles
R3550 T5196 T5197 det this,activity
R3551 T5197 T5195 pobj activity,of
R3552 T5198 T5197 compound repair,activity
R3553 T5199 T5194 prep in,complementation
R3554 T5200 T5201 det the,rescue
R3555 T5201 T5199 pobj rescue,in
R3556 T5202 T5201 prep of,rescue
R3557 T5203 T5204 nmod TTD,symptoms
R3558 T5204 T5202 pobj symptoms,of
R3559 T5205 T5204 amod progeroid,symptoms
R356 T682 T680 dobj alleles,carrying
R3560 T5206 T5207 advmod in,vivo
R3561 T5207 T5201 advmod vivo,rescue
R3562 T5208 T5173 punct .,argues
R3565 T5295 T5296 amod Interallelic,Complementation
R3566 T5297 T5296 cc and,Complementation
R3567 T5298 T5299 compound XPD,Function
R3568 T5299 T5296 conj Function,Complementation
R3569 T5301 T5302 dep What,tell
R357 T683 T682 amod different,alleles
R3570 T5303 T5302 aux does,tell
R3571 T5304 T5305 amod interallelic,complementation
R3572 T5305 T5302 nsubj complementation,tell
R3573 T5306 T5302 dobj us,tell
R3574 T5307 T5302 prep about,tell
R3575 T5308 T5309 det the,mechanism
R3576 T5309 T5307 pobj mechanism,about
R3577 T5310 T5309 prep of,mechanism
R3578 T5311 T5312 compound XPD,function
R3579 T5312 T5310 pobj function,of
R358 T684 T682 amod mutant,alleles
R3580 T5313 T5302 punct ?,tell
R3581 T5315 T5316 amod Interallelic,complementation
R3582 T5316 T5317 nsubjpass complementation,observed
R3583 T5318 T5317 auxpass is,observed
R3584 T5319 T5320 advmod most,often
R3585 T5320 T5317 advmod often,observed
R3586 T5321 T5317 prep in,observed
R3587 T5322 T5323 amod multimeric,proteins
R3588 T5323 T5321 pobj proteins,in
R3589 T5324 T5323 prep with,proteins
R359 T685 T682 prep of,alleles
R3590 T5325 T5326 amod multiple,domains
R3591 T5326 T5324 pobj domains,with
R3592 T5327 T5326 amod functional,domains
R3593 T5328 T5317 punct .,observed
R3594 T5330 T5331 advmod Unfortunately,remains
R3595 T5332 T5331 punct ", ",remains
R3596 T5333 T5334 det the,relationship
R3597 T5334 T5331 nsubj relationship,remains
R3598 T5335 T5336 compound structure,function
R3599 T5336 T5334 compound function,relationship
R360 T686 T687 det the,gene
R3600 T5337 T5336 punct –,function
R3601 T5338 T5334 prep between,relationship
R3602 T5339 T5340 npadvmod disease,causing
R3603 T5340 T5342 amod causing,mutations
R3604 T5341 T5340 punct -,causing
R3605 T5342 T5338 pobj mutations,between
R3606 T5343 T5342 cc and,mutations
R3607 T5344 T5345 nmod XPD,domains
R3608 T5345 T5342 conj domains,mutations
R3609 T5346 T5345 amod functional,domains
R361 T687 T685 pobj gene,of
R3610 T5347 T5334 punct ", ",relationship
R3611 T5348 T5334 prep including,relationship
R3612 T5349 T5350 amod detailed,information
R3613 T5350 T5348 pobj information,including
R3614 T5351 T5350 amod structural,information
R3615 T5352 T5350 prep on,information
R3616 T5353 T5352 pobj XPD,on
R3617 T5354 T5353 cc or,XPD
R3618 T5355 T5356 advmod even,stoichiometry
R3619 T5356 T5353 conj stoichiometry,XPD
R362 T688 T687 amod same,gene
R3620 T5357 T5356 poss its,stoichiometry
R3621 T5358 T5350 prep within,information
R3622 T5359 T5358 pobj TFIIH,within
R3623 T5360 T5331 punct ", ",remains
R3624 T5361 T5331 acomp unknown,remains
R3625 T5362 T5331 punct .,remains
R3626 T5364 T5365 advmod However,is
R3627 T5366 T5365 punct ", ",is
R3628 T5367 T5365 prep based,is
R3629 T5368 T5367 prep on,based
R363 T689 T678 punct .,are
R3630 T5369 T5370 det the,ability
R3631 T5370 T5368 pobj ability,on
R3632 T5371 T5370 prep of,ability
R3633 T5372 T5373 compound cell,extracts
R3634 T5373 T5371 pobj extracts,of
R3635 T5374 T5375 dep that,are
R3636 T5375 T5373 relcl are,extracts
R3637 T5376 T5375 acomp defective,are
R3638 T5377 T5376 prep in,defective
R3639 T5378 T5379 nummod two,components
R364 T691 T692 prep In,result
R3640 T5379 T5377 pobj components,in
R3641 T5380 T5379 amod different,components
R3642 T5381 T5379 compound TFIIH,components
R3643 T5382 T5379 punct (,components
R3644 T5383 T5379 appos XPD,components
R3645 T5384 T5383 cc and,XPD
R3646 T5385 T5383 conj XPB,XPD
R3647 T5386 T5370 punct ),ability
R3648 T5387 T5388 aux to,complement
R3649 T5388 T5370 acl complement,ability
R365 T693 T694 det the,absence
R3650 T5389 T5390 compound NER,activity
R3651 T5390 T5388 dobj activity,complement
R3652 T5391 T5392 advmod in,vitro
R3653 T5392 T5388 advmod vitro,complement
R3654 T5393 T5394 punct [,26
R3655 T5394 T5370 parataxis 26,ability
R3656 T5395 T5394 punct ],26
R3657 T5396 T5365 punct ", ",is
R3658 T5397 T5365 nsubj it,is
R3659 T5398 T5365 acomp likely,is
R366 T694 T691 pobj absence,In
R3660 T5399 T5400 mark that,multimerise
R3661 T5400 T5365 ccomp multimerise,is
R3662 T5401 T5400 nsubj TFIIH,multimerise
R3663 T5402 T5401 punct (,TFIIH
R3664 T5403 T5401 cc or,TFIIH
R3665 T5404 T5405 poss its,components
R3666 T5405 T5401 conj components,TFIIH
R3667 T5406 T5400 punct ),multimerise
R3668 T5407 T5400 aux can,multimerise
R3669 T5408 T5400 preconj either,multimerise
R367 T695 T694 prep of,absence
R3670 T5409 T5400 cc or,multimerise
R3671 T5410 T5400 conj exchange,multimerise
R3672 T5411 T5412 advmod at,least
R3673 T5412 T5413 advmod least,during
R3674 T5413 T5410 prep during,exchange
R3675 T5414 T5415 det the,reaction
R3676 T5415 T5413 pobj reaction,during
R3677 T5416 T5415 compound NER,reaction
R3678 T5417 T5365 punct .,is
R3679 T5419 T5420 advmod Furthermore,known
R368 T696 T697 det a,allele
R3680 T5421 T5420 punct ", ",known
R3681 T5422 T5420 nsubjpass XPD,known
R3682 T5423 T5420 auxpass is,known
R3683 T5424 T5425 aux to,be
R3684 T5425 T5420 xcomp be,known
R3685 T5426 T5427 det a,subunit
R3686 T5427 T5425 attr subunit,be
R3687 T5428 T5427 advmod “,subunit
R3688 T5429 T5430 advmod loosely,bound
R3689 T5430 T5427 amod bound,subunit
R369 T697 T695 pobj allele,of
R3690 T5431 T5427 punct ”,subunit
R3691 T5432 T5427 prep of,subunit
R3692 T5433 T5432 pobj TFIIH,of
R3693 T5434 T5435 punct [,27
R3694 T5435 T5420 parataxis 27,known
R3695 T5436 T5435 punct ],27
R3696 T5437 T5420 punct .,known
R3697 T5439 T5440 nsubj We,envisage
R3698 T5441 T5440 advmod thus,envisage
R3699 T5442 T5443 det the,mechanism
R370 T698 T697 amod dominant,allele
R3700 T5443 T5445 nsubj mechanism,involve
R3701 T5444 T5443 amod molecular,mechanism
R3702 T5445 T5440 ccomp involve,envisage
R3703 T5446 T5443 prep of,mechanism
R3704 T5447 T5448 amod interallelic,complementation
R3705 T5448 T5446 pobj complementation,of
R3706 T5449 T5445 aux to,involve
R3707 T5450 T5451 det the,exchange
R3708 T5451 T5445 dobj exchange,involve
R3709 T5452 T5451 prep of,exchange
R371 T699 T697 punct (,allele
R3710 T5453 T5454 compound XPD,molecules
R3711 T5454 T5452 pobj molecules,of
R3712 T5455 T5451 prep within,exchange
R3713 T5456 T5457 det the,complex
R3714 T5457 T5455 pobj complex,within
R3715 T5458 T5457 compound TFIIH,complex
R3716 T5459 T5451 cc or,exchange
R3717 T5460 T5451 conj turnover,exchange
R3718 T5461 T5460 prep of,turnover
R3719 T5462 T5463 compound TFIIH,complexes
R372 T700 T701 amod wild,type
R3720 T5463 T5461 pobj complexes,of
R3721 T5464 T5463 acl containing,complexes
R3722 T5465 T5466 amod different,molecules
R3723 T5466 T5464 dobj molecules,containing
R3724 T5467 T5466 compound XPD,molecules
R3725 T5468 T5460 prep at,turnover
R3726 T5469 T5470 det the,site
R3727 T5470 T5468 pobj site,at
R3728 T5471 T5470 prep of,site
R3729 T5472 T5473 compound DNA,damage
R373 T701 T697 nmod type,allele
R3730 T5473 T5471 pobj damage,of
R3731 T5474 T5460 prep during,turnover
R3732 T5475 T5476 det the,course
R3733 T5476 T5474 pobj course,during
R3734 T5477 T5476 prep of,course
R3735 T5478 T5479 det the,genome
R3736 T5479 T5477 pobj genome,of
R3737 T5480 T5479 amod global,genome
R3738 T5481 T5482 advmod as,as
R3739 T5482 T5451 cc as,exchange
R374 T702 T701 punct -,type
R3740 T5483 T5482 advmod well,as
R3741 T5484 T5485 npadvmod transcription,coupled
R3742 T5485 T5487 amod coupled,repair
R3743 T5486 T5485 punct -,coupled
R3744 T5487 T5451 conj repair,exchange
R3745 T5488 T5487 prep of,repair
R3746 T5489 T5490 preconj either,damage
R3747 T5490 T5488 pobj damage,of
R3748 T5491 T5492 npadvmod UV,induced
R3749 T5492 T5490 amod induced,damage
R375 T703 T701 punct [,type
R3750 T5493 T5492 punct -,induced
R3751 T5494 T5492 cc or,induced
R3752 T5495 T5492 conj endogenous,induced
R3753 T5496 T5490 compound DNA,damage
R3754 T5497 T5440 punct .,envisage
R3755 T5607 T5608 det A,Paradigm
R3756 T5609 T5608 amod Biallelic,Paradigm
R3757 T5610 T5608 prep for,Paradigm
R3758 T5611 T5612 compound XPD,Disorders
R3759 T5612 T5610 pobj Disorders,for
R376 T704 T701 appos wt,type
R3760 T5614 T5615 advmod Recently,characterised
R3761 T5616 T5615 punct ", ",characterised
R3762 T5617 T5615 nsubjpass proteins,characterised
R3763 T5618 T5617 acl originating,proteins
R3764 T5619 T5618 prep from,originating
R3765 T5620 T5621 amod presumed,alleles
R3766 T5621 T5619 pobj alleles,from
R3767 T5622 T5621 amod null,alleles
R3768 T5623 T5615 auxpass were,characterised
R3769 T5624 T5615 advmod biochemically,characterised
R377 T705 T697 punct ],allele
R3770 T5625 T5615 prep as,characterised
R3771 T5626 T5625 amod inactive,as
R3772 T5627 T5615 prep in,characterised
R3773 T5628 T5629 amod basal,transcription
R3774 T5629 T5627 pobj transcription,in
R3775 T5630 T5631 punct [,27
R3776 T5631 T5615 parataxis 27,characterised
R3777 T5632 T5631 punct ],27
R3778 T5633 T5615 punct ", ",characterised
R3779 T5634 T5615 advcl providing,characterised
R378 T706 T697 punct ),allele
R3780 T5635 T5636 det an,explanation
R3781 T5636 T5634 dobj explanation,providing
R3782 T5637 T5636 prep as,explanation
R3783 T5638 T5637 prep to,as
R3784 T5639 T5640 advmod why,failed
R3785 T5640 T5638 pcomp failed,to
R3786 T5641 T5642 det these,alleles
R3787 T5642 T5640 nsubj alleles,failed
R3788 T5643 T5644 aux to,rescue
R3789 T5644 T5640 xcomp rescue,failed
R379 T707 T692 punct ", ",result
R3790 T5645 T5644 dobj lethality,rescue
R3791 T5646 T5644 prep in,rescue
R3792 T5647 T5648 amod haploid,pombe
R3793 T5648 T5646 pobj pombe,in
R3794 T5649 T5648 nmod S.,pombe
R3795 T5650 T5648 prep with,pombe
R3796 T5651 T5652 det a,mutation
R3797 T5652 T5650 pobj mutation,with
R3798 T5653 T5652 amod null,mutation
R3799 T5654 T5652 prep in,mutation
R380 T708 T709 amod genetic,interactions
R3800 T5655 T5656 det the,homologue
R3801 T5656 T5654 pobj homologue,in
R3802 T5657 T5656 compound XPD,homologue
R3803 T5658 T5656 appos rad15,homologue
R3804 T5659 T5660 punct [,19
R3805 T5660 T5640 parataxis 19,failed
R3806 T5661 T5660 punct ],19
R3807 T5662 T5615 punct .,characterised
R3808 T5664 T5665 poss Our,data
R3809 T5665 T5666 nsubj data,suggest
R381 T709 T692 nsubj interactions,result
R3810 T5667 T5668 mark that,have
R3811 T5668 T5666 ccomp have,suggest
R3812 T5669 T5670 amod certain,alleles
R3813 T5670 T5668 nsubj alleles,have
R3814 T5671 T5672 advmod presumed,null
R3815 T5672 T5670 amod null,alleles
R3816 T5673 T5668 punct ", ",have
R3817 T5674 T5675 mark although,unable
R3818 T5675 T5668 advcl unable,have
R3819 T5676 T5677 prep on,support
R382 T710 T709 prep between,interactions
R3820 T5677 T5675 xcomp support,unable
R3821 T5678 T5679 poss their,own
R3822 T5679 T5676 pobj own,on
R3823 T5680 T5677 aux to,support
R3824 T5681 T5682 amod basal,transcription
R3825 T5682 T5677 dobj transcription,support
R3826 T5683 T5668 punct ", ",have
R3827 T5684 T5668 aux may,have
R3828 T5685 T5668 prep in,have
R3829 T5686 T5685 pobj fact,in
R383 T711 T712 amod recessive,alleles
R3830 T5687 T5688 det a,impact
R3831 T5688 T5668 dobj impact,have
R3832 T5689 T5688 amod substantial,impact
R3833 T5690 T5688 prep on,impact
R3834 T5691 T5692 compound disease,outcome
R3835 T5692 T5690 pobj outcome,on
R3836 T5693 T5688 prep in,impact
R3837 T5694 T5695 nmod compound,humans
R3838 T5695 T5693 pobj humans,in
R3839 T5696 T5695 amod heterozygous,humans
R384 T712 T710 pobj alleles,between
R3840 T5697 T5668 punct ", ",have
R3841 T5698 T5699 mark as,in
R3842 T5699 T5668 advcl in,have
R3843 T5700 T5699 nsubj they,in
R3844 T5701 T5699 aux do,in
R3845 T5702 T5703 compound mouse,models
R3846 T5703 T5699 pobj models,in
R3847 T5704 T5666 punct .,suggest
R3848 T5706 T5707 amod Clinical,evidence
R3849 T5707 T5708 nsubj evidence,comes
R385 T713 T709 punct (,interactions
R3850 T5709 T5707 prep in,evidence
R3851 T5710 T5709 pobj support,in
R3852 T5711 T5710 prep of,support
R3853 T5712 T5713 det this,hypothesis
R3854 T5713 T5711 pobj hypothesis,of
R3855 T5714 T5708 prep from,comes
R3856 T5715 T5716 det a,number
R3857 T5716 T5714 pobj number,from
R3858 T5717 T5716 prep of,number
R3859 T5718 T5719 compound XP,patients
R386 T714 T709 acl referred,interactions
R3860 T5719 T5717 pobj patients,of
R3861 T5720 T5719 compound complementation,patients
R3862 T5721 T5722 compound group,D
R3863 T5722 T5719 compound D,patients
R3864 T5723 T5724 dep that,fit
R3865 T5724 T5719 relcl fit,patients
R3866 T5725 T5724 aux do,fit
R3867 T5726 T5724 neg not,fit
R3868 T5727 T5724 prep within,fit
R3869 T5728 T5729 det the,framework
R387 T715 T714 prep to,referred
R3870 T5729 T5727 pobj framework,within
R3871 T5730 T5729 prep of,framework
R3872 T5731 T5732 det the,paradigm
R3873 T5732 T5730 pobj paradigm,of
R3874 T5733 T5732 amod current,paradigm
R3875 T5734 T5732 amod monoallelic,paradigm
R3876 T5735 T5732 prep of,paradigm
R3877 T5736 T5737 compound XPD,disorders
R3878 T5737 T5735 pobj disorders,of
R3879 T5738 T5739 punct (,Figure
R388 T716 T714 advmod here,referred
R3880 T5739 T5708 parataxis Figure,comes
R3881 T5740 T5739 nummod 5,Figure
R3882 T5741 T5739 punct ),Figure
R3883 T5742 T5708 punct .,comes
R3884 T5744 T5745 prep In,had
R3885 T5746 T5744 pobj contrast,In
R3886 T5747 T5746 prep to,contrast
R3887 T5748 T5749 nummod two,patients
R3888 T5749 T5747 pobj patients,to
R3889 T5750 T5749 amod hemizygous,patients
R389 T717 T714 prep as,referred
R3890 T5751 T5749 compound XPDXPCS,patients
R3891 T5752 T5749 acl carrying,patients
R3892 T5753 T5754 det the,alleles
R3893 T5754 T5752 dobj alleles,carrying
R3894 T5755 T5756 npadvmod XPDG47R,encoding
R3895 T5756 T5754 amod encoding,alleles
R3896 T5757 T5755 punct -,XPDG47R
R3897 T5758 T5755 cc or,XPDG47R
R3898 T5759 T5755 conj XPDR666W,XPDG47R
R3899 T5760 T5756 punct -,encoding
R390 T718 T717 punct “,as
R3900 T5761 T5762 dep who,died
R3901 T5762 T5754 relcl died,alleles
R3902 T5763 T5762 prep of,died
R3903 T5764 T5765 det the,disease
R3904 T5765 T5763 pobj disease,of
R3905 T5766 T5762 prep before,died
R3906 T5767 T5768 nummod 2,y
R3907 T5768 T5766 pobj y,before
R3908 T5769 T5768 prep of,y
R3909 T5770 T5769 pobj age,of
R391 T719 T720 amod biallelic,effects
R3910 T5771 T5745 punct ", ",had
R3911 T5772 T5773 nummod two,patients
R3912 T5773 T5745 nsubj patients,had
R3913 T5774 T5773 amod compound,patients
R3914 T5775 T5773 amod heterozygous,patients
R3915 T5776 T5773 compound XPDXPCS,patients
R3916 T5777 T5773 acl carrying,patients
R3917 T5778 T5779 det the,alleles
R3918 T5779 T5777 dobj alleles,carrying
R3919 T5780 T5779 amod same,alleles
R392 T720 T717 pobj effects,as
R3920 T5781 T5782 npadvmod XPDG47R,encoding
R3921 T5782 T5779 amod encoding,alleles
R3922 T5783 T5781 punct -,XPDG47R
R3923 T5784 T5781 cc or,XPDG47R
R3924 T5785 T5781 conj XPDR666W,XPDG47R
R3925 T5786 T5782 punct -,encoding
R3926 T5787 T5779 prep in,alleles
R3927 T5788 T5787 pobj addition,in
R3928 T5789 T5788 prep to,addition
R3929 T5790 T5791 det the,730
R393 T721 T720 punct ”,effects
R3930 T5791 T5789 pobj 730,to
R3931 T5792 T5793 advmod presumed,null
R3932 T5793 T5791 amod null,730
R3933 T5794 T5791 nmod XPDL461V,730
R3934 T5795 T5791 punct +,730
R3935 T5796 T5791 compound del716,730
R3936 T5797 T5791 punct −,730
R3937 T5798 T5773 appos both,patients
R3938 T5799 T5800 advmod considerably,milder
R3939 T5800 T5801 amod milder,symptoms
R394 T722 T692 punct ),result
R3940 T5801 T5745 dobj symptoms,had
R3941 T5802 T5801 compound disease,symptoms
R3942 T5803 T5745 cc and,had
R3943 T5804 T5745 conj survived,had
R3944 T5805 T5806 amod more,ten
R3945 T5806 T5808 nummod ten,times
R3946 T5807 T5806 quantmod than,ten
R3947 T5808 T5809 npadvmod times,longer
R3948 T5809 T5804 advmod longer,survived
R3949 T5810 T5811 punct (,A.
R395 T723 T692 aux could,result
R3950 T5811 T5804 meta A.,survived
R3951 T5812 T5811 nmod Lehmann,A.
R3952 T5813 T5811 punct ", ",A.
R3953 T5814 T5811 amod personal,A.
R3954 T5815 T5811 nmod communication,A.
R3955 T5816 T5811 punct ),A.
R3956 T5817 T5818 punct (,Figure
R3957 T5818 T5804 parataxis Figure,survived
R3958 T5819 T5818 nummod 5,Figure
R3959 T5820 T5818 punct ),Figure
R396 T724 T692 prep in,result
R3960 T5821 T5745 punct .,had
R3961 T5823 T5824 compound Compound,heterozygosity
R3962 T5824 T5825 nsubjpass heterozygosity,associated
R3963 T5826 T5825 auxpass is,associated
R3964 T5827 T5825 advmod also,associated
R3965 T5828 T5825 prep with,associated
R3966 T5829 T5830 det the,syndrome
R3967 T5830 T5828 pobj syndrome,with
R3968 T5831 T5832 advmod recently,reported
R3969 T5832 T5830 amod reported,syndrome
R397 T725 T726 amod different,outcomes
R3970 T5833 T5830 nmod combination,syndrome
R3971 T5834 T5830 nmod XP,syndrome
R3972 T5835 T5834 cc and,XP
R3973 T5836 T5834 conj TTD,XP
R3974 T5837 T5838 punct (,XPTTD
R3975 T5838 T5836 parataxis XPTTD,TTD
R3976 T5839 T5838 punct ),XPTTD
R3977 T5840 T5841 punct [,8
R3978 T5841 T5825 parataxis 8,associated
R3979 T5842 T5841 punct ],8
R398 T726 T724 pobj outcomes,in
R3980 T5843 T5825 punct .,associated
R3981 T5845 T5846 advcl Similar,had
R3982 T5847 T5845 prep to,Similar
R3983 T5848 T5849 det the,mice
R3984 T5849 T5847 pobj mice,to
R3985 T5850 T5851 nmod XpdTTD,†XPCS
R3986 T5851 T5849 nmod †XPCS,mice
R3987 T5852 T5851 punct /,†XPCS
R3988 T5853 T5851 cc and,†XPCS
R3989 T5854 T5855 compound XpdTTD,†XP
R399 T727 T726 amod phenotypic,outcomes
R3990 T5855 T5851 conj †XP,†XPCS
R3991 T5856 T5855 punct /,†XP
R3992 T5857 T5849 acl described,mice
R3993 T5858 T5857 advmod here,described
R3994 T5859 T5846 punct ", ",had
R3995 T5860 T5861 det both,patients
R3996 T5861 T5846 nsubj patients,had
R3997 T5862 T5861 prep with,patients
R3998 T5863 T5862 pobj XPTTD,with
R3999 T5864 T5861 acl described,patients
R400 T728 T726 prep including,outcomes
R4000 T5865 T5866 advmod so,far
R4001 T5866 T5864 advmod far,described
R4002 T5867 T5868 amod intermediate,values
R4003 T5868 T5846 dobj values,had
R4004 T5869 T5870 compound hair,cysteine
R4005 T5870 T5868 compound cysteine,values
R4006 T5871 T5846 punct .,had
R4007 T5873 T5874 advmod Furthermore,carried
R4008 T5875 T5874 punct ", ",carried
R4009 T5876 T5877 compound XPTTD,XP38BR
R401 T729 T730 amod interallelic,complementation
R4010 T5877 T5874 nsubj XP38BR,carried
R4011 T5878 T5877 compound patient,XP38BR
R4012 T5879 T5880 det a,mutation
R4013 T5880 T5874 dobj mutation,carried
R4014 T5881 T5880 punct “,mutation
R4015 T5882 T5880 amod causative,mutation
R4016 T5883 T5880 punct ”,mutation
R4017 T5884 T5880 compound TTD,mutation
R4018 T5885 T5874 prep in,carried
R4019 T5886 T5887 nummod one,allele
R402 T730 T728 pobj complementation,including
R4020 T5887 T5885 pobj allele,in
R4021 T5888 T5874 cc and,carried
R4022 T5889 T5890 det a,mutation
R4023 T5890 T5874 conj mutation,carried
R4024 T5891 T5890 amod novel,mutation
R4025 T5892 T5890 compound point,mutation
R4026 T5893 T5890 acl encoding,mutation
R4027 T5894 T5893 dobj XPDL485P,encoding
R4028 T5895 T5890 prep in,mutation
R4029 T5896 T5897 det the,other
R403 T731 T692 punct .,result
R4030 T5897 T5895 pobj other,in
R4031 T5898 T5874 punct .,carried
R4032 T5900 T5901 mark Although,fails
R4033 T5901 T5907 advcl fails,suggest
R4034 T5902 T5903 det the,allele
R4035 T5903 T5901 nsubj allele,fails
R4036 T5904 T5905 npadvmod XPDL485P,encoding
R4037 T5905 T5903 amod encoding,allele
R4038 T5906 T5905 punct -,encoding
R4039 T5908 T5909 aux to,complement
R404 T733 T734 mark Although,create
R4040 T5909 T5901 xcomp complement,fails
R4041 T5910 T5909 dobj viability,complement
R4042 T5911 T5909 prep in,complement
R4043 T5912 T5913 det the,strain
R4044 T5913 T5911 pobj strain,in
R4045 T5914 T5913 amod haploid,strain
R4046 T5915 T5913 nmod S.,strain
R4047 T5916 T5913 nmod pombe,strain
R4048 T5917 T5913 compound rad15,strain
R4049 T5918 T5913 compound deletion,strain
R405 T734 T743 advcl create,caused
R4050 T5919 T5901 cc and,fails
R4051 T5920 T5901 conj is,fails
R4052 T5921 T5920 advmod thus,is
R4053 T5922 T5920 acomp interpretable,is
R4054 T5923 T5922 prep as,interpretable
R4055 T5924 T5925 det a,allele
R4056 T5925 T5923 pobj allele,as
R4057 T5926 T5925 amod null,allele
R4058 T5927 T5928 punct [,8
R4059 T5928 T5920 parataxis 8,is
R406 T735 T734 nsubj amelioration,create
R4060 T5929 T5928 punct ],8
R4061 T5930 T5907 punct ", ",suggest
R4062 T5931 T5907 nsubj we,suggest
R4063 T5932 T5907 advmod nonetheless,suggest
R4064 T5933 T5934 mark that,involves
R4065 T5934 T5907 ccomp involves,suggest
R4066 T5935 T5936 det the,phenotype
R4067 T5936 T5934 nsubj phenotype,involves
R4068 T5937 T5936 amod combined,phenotype
R4069 T5938 T5936 compound XPTTD,phenotype
R407 T736 T735 prep of,amelioration
R4070 T5939 T5936 prep in,phenotype
R4071 T5940 T5941 det this,patient
R4072 T5941 T5939 pobj patient,in
R4073 T5942 T5943 amod phenotypic,contributions
R4074 T5943 T5934 dobj contributions,involves
R4075 T5944 T5943 prep from,contributions
R4076 T5945 T5946 det both,alleles
R4077 T5946 T5944 pobj alleles,from
R4078 T5947 T5907 punct .,suggest
R4079 T5949 T5950 advcl Taken,suggest
R408 T737 T738 compound disease,symptoms
R4080 T5951 T5949 advmod together,Taken
R4081 T5952 T5950 punct ", ",suggest
R4082 T5953 T5954 det these,data
R4083 T5954 T5950 nsubj data,suggest
R4084 T5955 T5956 det a,shift
R4085 T5956 T5950 dobj shift,suggest
R4086 T5957 T5956 prep to,shift
R4087 T5958 T5959 det a,paradigm
R4088 T5959 T5957 pobj paradigm,to
R4089 T5960 T5959 amod biallelic,paradigm
R409 T738 T736 pobj symptoms,of
R4090 T5961 T5959 prep for,paradigm
R4091 T5962 T5963 nmod compound,patients
R4092 T5963 T5961 pobj patients,for
R4093 T5964 T5963 amod heterozygous,patients
R4094 T5965 T5963 prep in,patients
R4095 T5966 T5967 compound XP,D
R4096 T5967 T5965 pobj D,in
R4097 T5968 T5967 compound complementation,D
R4098 T5969 T5967 compound group,D
R4099 T5970 T5950 punct .,suggest
R410 T739 T735 prep by,amelioration
R4100 T6042 T6041 prep of,Potential
R4101 T6043 T6044 amod Combined,Alleles
R4102 T6044 T6042 pobj Alleles,of
R4103 T6045 T6044 amod Recessive,Alleles
R4104 T6046 T6047 aux to,Affect
R4105 T6047 T6041 acl Affect,Potential
R4106 T6048 T6049 amod Phenotypic,Diversity
R4107 T6049 T6047 dobj Diversity,Affect
R4108 T6050 T6047 prep in,Affect
R4109 T6051 T6050 pobj Mammals,in
R411 T740 T741 amod interallelic,complementation
R4110 T6053 T6054 prep In,remains
R4111 T6055 T6053 pobj humans,In
R4112 T6056 T6054 punct ", ",remains
R4113 T6057 T6058 det the,relevance
R4114 T6058 T6054 nsubj relevance,remains
R4115 T6059 T6058 amod clinical,relevance
R4116 T6060 T6058 prep of,relevance
R4117 T6061 T6062 amod biallelic,effects
R4118 T6062 T6060 pobj effects,of
R4119 T6063 T6064 amod such,as
R412 T741 T739 pobj complementation,by
R4120 T6064 T6062 prep as,effects
R4121 T6065 T6066 amod interallelic,complementation
R4122 T6066 T6064 pobj complementation,as
R4123 T6067 T6054 acomp unknown,remains
R4124 T6068 T6054 punct .,remains
R4125 T6070 T6071 mark Although,described
R4126 T6071 T6081 advcl described,noted
R4127 T6072 T6073 amod interallelic,complementation
R4128 T6073 T6071 nsubjpass complementation,described
R4129 T6074 T6073 prep between,complementation
R413 T742 T734 aux would,create
R4130 T6075 T6076 nummod two,alleles
R4131 T6076 T6074 pobj alleles,between
R4132 T6077 T6076 amod endogenous,alleles
R4133 T6078 T6076 amod mutant,alleles
R4134 T6079 T6071 aux has,described
R4135 T6080 T6071 auxpass been,described
R4136 T6082 T6071 prep in,described
R4137 T6083 T6082 pobj cells,in
R4138 T6084 T6083 prep from,cells
R4139 T6085 T6086 det a,patient
R414 T744 T745 det an,bias
R4140 T6086 T6084 pobj patient,from
R4141 T6087 T6086 nmod compound,patient
R4142 T6088 T6086 amod heterozygous,patient
R4143 T6089 T6086 prep with,patient
R4144 T6090 T6091 amod methylmalonic,acidaemia
R4145 T6091 T6089 pobj acidaemia,with
R4146 T6092 T6081 punct ", ",noted
R4147 T6093 T6094 det no,effects
R4148 T6094 T6081 nsubjpass effects,noted
R4149 T6095 T6094 amod observable,effects
R415 T745 T734 dobj bias,create
R4150 T6096 T6094 prep on,effects
R4151 T6097 T6098 compound disease,outcome
R4152 T6098 T6096 pobj outcome,on
R4153 T6099 T6081 auxpass were,noted
R4154 T6100 T6081 prep in,noted
R4155 T6101 T6102 det the,patient
R4156 T6102 T6100 pobj patient,in
R4157 T6103 T6104 punct [,28
R4158 T6104 T6081 parataxis 28,noted
R4159 T6105 T6104 punct ],28
R416 T746 T745 compound ascertainment,bias
R4160 T6106 T6081 punct .,noted
R4161 T6108 T6109 advmod Thus,is
R4162 T6110 T6109 punct ", ",is
R4163 T6111 T6109 prep to,is
R4164 T6112 T6113 det the,best
R4165 T6113 T6111 pobj best,to
R4166 T6114 T6113 prep of,best
R4167 T6115 T6116 poss our,knowledge
R4168 T6116 T6114 pobj knowledge,of
R4169 T6117 T6109 punct ", ",is
R417 T747 T734 prep in,create
R4170 T6118 T6119 det the,amelioration
R4171 T6119 T6109 nsubj amelioration,is
R4172 T6120 T6119 prep of,amelioration
R4173 T6121 T6122 amod progeroid,features
R4174 T6122 T6120 pobj features,of
R4175 T6123 T6119 acl observed,amelioration
R4176 T6124 T6123 advmod here,observed
R4177 T6125 T6126 det the,demonstration
R4178 T6126 T6109 attr demonstration,is
R4179 T6127 T6126 amod first,demonstration
R418 T748 T749 det the,clinic
R4180 T6128 T6129 advmod in,vivo
R4181 T6129 T6126 amod vivo,demonstration
R4182 T6130 T6126 prep in,demonstration
R4183 T6131 T6132 nmod compound,animals
R4184 T6132 T6130 pobj animals,in
R4185 T6133 T6132 amod heterozygous,animals
R4186 T6134 T6132 prep of,animals
R4187 T6135 T6136 amod interallelic,complementation
R4188 T6136 T6134 pobj complementation,of
R4189 T6137 T6126 amod relevant,demonstration
R419 T749 T747 pobj clinic,in
R4190 T6138 T6137 prep to,relevant
R4191 T6139 T6140 det a,disease
R4192 T6140 T6138 pobj disease,to
R4193 T6141 T6140 amod human,disease
R4194 T6142 T6109 punct .,is
R4195 T6144 T6145 advcl Keeping,is
R4196 T6146 T6144 prep in,Keeping
R4197 T6147 T6146 pobj mind,in
R4198 T6148 T6149 mark that,result
R4199 T6149 T6144 ccomp result,Keeping
R420 T750 T743 punct ", ",caused
R4200 T6150 T6151 det the,alleles
R4201 T6151 T6149 nsubj alleles,result
R4202 T6152 T6153 punct ~,"1,200"
R4203 T6153 T6151 nummod "1,200",alleles
R4204 T6154 T6151 acl known,alleles
R4205 T6155 T6156 aux to,exist
R4206 T6156 T6154 xcomp exist,known
R4207 T6157 T6156 prep for,exist
R4208 T6158 T6159 det the,gene
R4209 T6159 T6157 pobj gene,for
R421 T751 T752 det the,lack
R4210 T6160 T6159 compound CTRF,gene
R4211 T6161 T6159 acl implicated,gene
R4212 T6162 T6161 prep in,implicated
R4213 T6163 T6164 det the,disorder
R4214 T6164 T6162 pobj disorder,in
R4215 T6165 T6164 amod common,disorder
R4216 T6166 T6164 amod autosomal,disorder
R4217 T6167 T6164 amod recessive,disorder
R4218 T6168 T6169 amod cystic,fibrosis
R4219 T6169 T6164 appos fibrosis,disorder
R422 T752 T743 nsubjpass lack,caused
R4220 T6170 T6161 advmod alone,implicated
R4221 T6171 T6172 punct [,29
R4222 T6172 T6154 parataxis 29,known
R4223 T6173 T6172 punct ],29
R4224 T6174 T6149 aux can,result
R4225 T6175 T6149 advmod theoretically,result
R4226 T6176 T6149 prep in,result
R4227 T6177 T6178 punct ~,"700,000"
R4228 T6178 T6179 nummod "700,000",combinations
R4229 T6179 T6176 pobj combinations,in
R423 T753 T752 prep of,lack
R4230 T6180 T6179 amod different,combinations
R4231 T6181 T6179 amod allelic,combinations
R4232 T6182 T6145 punct ", ",is
R4233 T6183 T6184 det the,number
R4234 T6184 T6145 nsubj number,is
R4235 T6185 T6184 amod potential,number
R4236 T6186 T6184 prep of,number
R4237 T6187 T6188 amod allelic,combinations
R4238 T6188 T6186 pobj combinations,of
R4239 T6189 T6188 prep of,combinations
R424 T754 T753 pobj evidence,of
R4240 T6190 T6191 amod different,mutations
R4241 T6191 T6189 pobj mutations,of
R4242 T6192 T6191 amod recessive,mutations
R4243 T6193 T6191 cc and,mutations
R4244 T6194 T6195 amod single,polymorphisms
R4245 T6195 T6191 conj polymorphisms,mutations
R4246 T6196 T6195 compound nucleotide,polymorphisms
R4247 T6197 T6198 npadvmod genome,wide
R4248 T6198 T6184 amod wide,number
R4249 T6199 T6198 punct -,wide
R425 T755 T754 prep concerning,evidence
R4250 T6200 T6145 advmod currently,is
R4251 T6201 T6145 acomp incalculable,is
R4252 T6202 T6145 punct .,is
R4253 T6204 T6205 nsubj We,suggest
R4254 T6206 T6207 amod biallelic,effects
R4255 T6207 T6205 dobj effects,suggest
R4256 T6208 T6205 prep as,suggest
R4257 T6209 T6210 det a,variable
R4258 T6210 T6208 pobj variable,as
R4259 T6211 T6212 advmod previously,underestimated
R426 T756 T757 amod interallelic,complementation
R4260 T6212 T6213 amod underestimated,important
R4261 T6213 T6210 amod important,variable
R4262 T6214 T6213 advmod yet,important
R4263 T6215 T6205 prep in,suggest
R4264 T6216 T6215 pcomp considering,in
R4265 T6217 T6218 compound genotype,phenotype
R4266 T6218 T6220 compound phenotype,relationships
R4267 T6219 T6218 punct –,phenotype
R4268 T6220 T6216 dobj relationships,considering
R4269 T6221 T6216 prep from,considering
R427 T757 T755 pobj complementation,concerning
R4270 T6222 T6223 amod autosomal,disease
R4271 T6223 T6221 pobj disease,from
R4272 T6224 T6223 amod recessive,disease
R4273 T6225 T6221 prep to,from
R4274 T6226 T6227 amod normal,diversity
R4275 T6227 T6225 pobj diversity,to
R4276 T6228 T6227 amod phenotypic,diversity
R4277 T6229 T6216 prep in,considering
R4278 T6230 T6229 pobj mammals,in
R4279 T6231 T6205 punct .,suggest
R428 T758 T757 cc or,complementation
R4280 T6233 T6234 nsubj Extension,implies
R4281 T6235 T6233 prep of,Extension
R4282 T6236 T6237 det the,concept
R4283 T6237 T6235 pobj concept,of
R4284 T6238 T6237 amod above,concept
R4285 T6239 T6240 mark that,enter
R4286 T6240 T6234 ccomp enter,implies
R4287 T6241 T6242 amod recessive,mutations
R4288 T6242 T6240 nsubj mutations,enter
R4289 T6243 T6240 aux can,enter
R429 T759 T760 amod other,effects
R4290 T6244 T6245 amod evolutionary,selection
R4291 T6245 T6240 dobj selection,enter
R4292 T6246 T6240 prep in,enter
R4293 T6247 T6246 pobj F1,in
R4294 T6248 T6240 prep provided,enter
R4295 T6249 T6250 mark that,carries
R4296 T6250 T6248 pcomp carries,provided
R4297 T6251 T6252 det the,allele
R4298 T6252 T6250 nsubj allele,carries
R4299 T6253 T6252 amod second,allele
R430 T760 T757 conj effects,complementation
R4300 T6254 T6255 det a,alteration
R4301 T6255 T6250 dobj alteration,carries
R4302 T6256 T6255 amod different,alteration
R4303 T6257 T6255 amod recessive,alteration
R4304 T6258 T6234 punct .,implies
R4305 T6260 T6261 advmod Finally,highlight
R4306 T6262 T6261 punct ", ",highlight
R4307 T6263 T6264 poss our,data
R4308 T6264 T6261 nsubj data,highlight
R4309 T6265 T6266 det the,potential
R431 T761 T760 amod biallelic,effects
R4310 T6266 T6261 dobj potential,highlight
R4311 T6267 T6266 prep of,potential
R4312 T6268 T6269 advmod clinically,relevant
R4313 T6269 T6270 amod relevant,alleles
R4314 T6270 T6267 pobj alleles,of
R4315 T6271 T6272 advmod previously,designated
R4316 T6272 T6270 acl designated,alleles
R4317 T6273 T6272 prep as,designated
R4318 T6274 T6273 amod null,as
R4319 T6275 T6270 punct ", ",alleles
R432 T762 T757 prep in,complementation
R4320 T6276 T6270 prep with,alleles
R4321 T6277 T6278 amod little,expression
R4322 T6278 T6276 pobj expression,with
R4323 T6279 T6277 cc or,little
R4324 T6280 T6277 conj no,little
R4325 T6281 T6278 amod detectable,expression
R4326 T6282 T6278 cc or,expression
R4327 T6283 T6278 conj activity,expression
R4328 T6284 T6266 punct ", ",potential
R4329 T6285 T6286 aux to,contribute
R433 T763 T764 amod human,disease
R4330 T6286 T6266 acl contribute,potential
R4331 T6287 T6286 advmod nonetheless,contribute
R4332 T6288 T6286 prep to,contribute
R4333 T6289 T6288 pobj phenotype,to
R4334 T6290 T6261 punct .,highlight
R4335 T6365 T6364 cc and,Derivation
R4336 T6366 T6364 conj analysis,Derivation
R4337 T6367 T6364 prep of,Derivation
R4338 T6368 T6369 amod mutant,mice
R4339 T6369 T6367 pobj mice,of
R434 T764 T762 pobj disease,in
R4340 T6370 T6364 punct .,Derivation
R4341 T6372 T6373 nsubjpass Generation,described
R4342 T6374 T6372 prep of,Generation
R4343 T6375 T6376 nmod XpdTTD,mice
R4344 T6376 T6374 pobj mice,of
R4345 T6377 T6378 punct (,XPDR722W
R4346 T6378 T6375 parataxis XPDR722W,XpdTTD
R4347 T6379 T6378 punct ),XPDR722W
R4348 T6380 T6375 cc and,XpdTTD
R4349 T6381 T6382 compound XpdTTD,KO
R435 T765 T743 auxpass is,caused
R4350 T6382 T6375 conj KO,XpdTTD
R4351 T6383 T6382 punct /,KO
R4352 T6384 T6373 aux has,described
R4353 T6385 T6373 auxpass been,described
R4354 T6386 T6373 advmod previously,described
R4355 T6387 T6388 punct [,22
R4356 T6388 T6373 parataxis 22,described
R4357 T6389 T6388 nummod 21,22
R4358 T6390 T6388 punct ",",22
R4359 T6391 T6388 punct ],22
R436 T766 T743 advmod likely,caused
R4360 T6392 T6373 punct .,described
R4361 T6394 T6395 det A,description
R4362 T6395 T6397 nsubjpass description,provided
R4363 T6396 T6395 amod detailed,description
R4364 T6398 T6395 prep of,description
R4365 T6399 T6400 det the,generation
R4366 T6400 T6398 pobj generation,of
R4367 T6401 T6400 prep of,generation
R4368 T6402 T6403 amod targeting,constructs
R4369 T6403 T6401 pobj constructs,of
R437 T767 T743 agent by,caused
R4370 T6404 T6403 prep for,constructs
R4371 T6405 T6406 nmod Xpd†XPCS,alleles
R4372 T6406 T6404 pobj alleles,for
R4373 T6407 T6405 cc and,Xpd†XPCS
R4374 T6408 T6405 conj Xpd †XP,Xpd†XPCS
R4375 T6409 T6406 acl carrying,alleles
R4376 T6410 T6409 dobj mutations,carrying
R4377 T6411 T6410 acl encoding,mutations
R4378 T6412 T6413 det the,alterations
R4379 T6413 T6411 dobj alterations,encoding
R438 T768 T769 det the,difficulty
R4380 T6414 T6413 nmod G602D,alterations
R4381 T6415 T6414 cc and,G602D
R4382 T6416 T6414 conj R683W,G602D
R4383 T6417 T6397 aux will,provided
R4384 T6418 T6397 auxpass be,provided
R4385 T6419 T6397 prep upon,provided
R4386 T6420 T6419 pobj request,upon
R4387 T6421 T6397 punct .,provided
R4388 T6423 T6424 amod Chimeric,fibroblasts
R4389 T6424 T6429 nsubjpass fibroblasts,generated
R439 T769 T767 pobj difficulty,by
R4390 T6425 T6424 nmod mice,fibroblasts
R4391 T6426 T6425 cc and,mice
R4392 T6427 T6428 npadvmod mouse,embryonic
R4393 T6428 T6425 conj embryonic,mice
R4394 T6430 T6429 auxpass were,generated
R4395 T6431 T6429 prep according,generated
R4396 T6432 T6431 prep to,according
R4397 T6433 T6434 amod standard,procedures
R4398 T6434 T6432 pobj procedures,to
R4399 T6435 T6429 punct .,generated
R440 T770 T769 prep in,difficulty
R4400 T6437 T6438 nmod Haematoxylin,staining
R4401 T6438 T6441 nsubjpass staining,performed
R4402 T6439 T6437 cc and,Haematoxylin
R4403 T6440 T6437 conj eosin,Haematoxylin
R4404 T6442 T6441 auxpass was,performed
R4405 T6443 T6441 prep according,performed
R4406 T6444 T6443 prep to,according
R4407 T6445 T6446 amod standard,procedures
R4408 T6446 T6444 pobj procedures,to
R4409 T6447 T6441 punct .,performed
R441 T771 T770 pcomp distinguishing,in
R4410 T6449 T6450 compound Amino,acid
R4411 T6450 T6451 compound acid,analysis
R4412 T6451 T6452 nsubjpass analysis,conducted
R4413 T6453 T6452 auxpass was,conducted
R4414 T6454 T6455 mark as,described
R4415 T6455 T6452 advcl described,conducted
R4416 T6456 T6455 prep in,described
R4417 T6457 T6456 punct [,in
R4418 T6458 T6456 pobj 21,in
R4419 T6459 T6452 punct ],conducted
R442 T772 T773 amod such,effects
R4420 T6460 T6452 punct .,conducted
R4421 T6462 T6463 compound Blood,values
R4422 T6463 T6464 nsubjpass values,analysed
R4423 T6465 T6464 auxpass were,analysed
R4424 T6466 T6464 advcl using,analysed
R4425 T6467 T6468 nmod Animal,Vet
R4426 T6468 T6466 dobj Vet,using
R4427 T6469 T6468 nmod Blood,Vet
R4428 T6470 T6468 amod Counter,Vet
R4429 T6471 T6472 punct (,Diagnostix
R443 T773 T771 dobj effects,distinguishing
R4430 T6472 T6468 parataxis Diagnostix,Vet
R4431 T6473 T6472 compound ABX,Diagnostix
R4432 T6474 T6472 punct ", ",Diagnostix
R4433 T6475 T6472 npadvmod Montpellier,Diagnostix
R4434 T6476 T6472 punct ", ",Diagnostix
R4435 T6477 T6472 npadvmod France,Diagnostix
R4436 T6478 T6472 punct ),Diagnostix
R4437 T6479 T6464 punct .,analysed
R4438 T6481 T6482 nsubjpass Radiographs,taken
R4439 T6483 T6482 auxpass were,taken
R444 T774 T771 prep from,distinguishing
R4440 T6484 T6482 punct ", ",taken
R4441 T6485 T6482 cc and,taken
R4442 T6486 T6487 amod relative,density
R4443 T6487 T6490 nsubjpass density,calculated
R4444 T6488 T6489 compound bone,mineral
R4445 T6489 T6487 compound mineral,density
R4446 T6490 T6482 conj calculated,taken
R4447 T6491 T6490 auxpass was,calculated
R4448 T6492 T6493 mark as,described
R4449 T6493 T6490 advcl described,calculated
R445 T775 T774 pobj environment,from
R4450 T6494 T6493 prep in,described
R4451 T6495 T6494 punct [,in
R4452 T6496 T6494 pobj 15,in
R4453 T6497 T6490 punct ],calculated
R4454 T6498 T6490 punct .,calculated
R4455 T6500 T6501 nsubj Mice,were
R4456 T6502 T6500 acl used,Mice
R4457 T6503 T6502 prep in,used
R4458 T6504 T6505 det this,study
R4459 T6505 T6503 pobj study,in
R446 T776 T775 cc and,environment
R4460 T6506 T6501 prep in,were
R4461 T6507 T6508 det a,background
R4462 T6508 T6506 pobj background,in
R4463 T6509 T6510 nmod 129Ola,C57BL6
R4464 T6510 T6508 nmod C57BL6,background
R4465 T6511 T6510 punct /,C57BL6
R4466 T6512 T6508 amod mixed,background
R4467 T6513 T6514 mark unless,noted
R4468 T6514 T6501 advcl noted,were
R4469 T6515 T6514 advmod differently,noted
R447 T777 T778 amod genetic,background
R4470 T6516 T6501 punct .,were
R4471 T6518 T6519 det All,experiments
R4472 T6519 T6520 nsubjpass experiments,judged
R4473 T6521 T6519 acl involving,experiments
R4474 T6522 T6521 dobj mice,involving
R4475 T6523 T6520 auxpass were,judged
R4476 T6524 T6520 cc and,judged
R4477 T6525 T6520 conj approved,judged
R4478 T6526 T6525 agent by,approved
R4479 T6527 T6528 det the,committee
R448 T778 T775 conj background,environment
R4480 T6528 T6526 pobj committee,by
R4481 T6529 T6528 amod national,committee
R4482 T6530 T6528 prep for,committee
R4483 T6531 T6532 amod genetic,identification
R4484 T6532 T6530 pobj identification,for
R4485 T6533 T6532 prep of,identification
R4486 T6534 T6533 pobj organisms,of
R4487 T6535 T6528 cc and,committee
R4488 T6536 T6537 det the,committee
R4489 T6537 T6528 conj committee,committee
R449 T779 T743 punct .,caused
R4490 T6538 T6537 nmod animal,committee
R4491 T6539 T6537 amod ethical,committee
R4492 T6540 T6520 punct ", ",judged
R4493 T6541 T6520 cc and,judged
R4494 T6542 T6543 auxpass were,conducted
R4495 T6543 T6520 conj conducted,judged
R4496 T6544 T6543 prep according,conducted
R4497 T6545 T6544 prep to,according
R4498 T6546 T6547 amod national,guidelines
R4499 T6547 T6545 pobj guidelines,to
R450 T781 T782 nsubj XPD,encodes
R4500 T6548 T6546 cc and,national
R4501 T6549 T6546 conj international,national
R4502 T6550 T6520 punct .,judged
R4503 T6587 T6588 compound UV,sensitivity
R4504 T6589 T6588 punct ", ",sensitivity
R4505 T6590 T6591 nmod UV,UDS
R4506 T6591 T6593 nmod UDS,activity
R4507 T6592 T6591 punct -,UDS
R4508 T6593 T6588 appos activity,sensitivity
R4509 T6594 T6591 punct ", ",UDS
R451 T783 T782 dobj one,encodes
R4510 T6595 T6596 compound UV,RRS
R4511 T6596 T6591 conj RRS,UDS
R4512 T6597 T6596 punct -,RRS
R4513 T6598 T6596 punct ", ",RRS
R4514 T6599 T6596 cc and,RRS
R4515 T6600 T6596 conj TFIIH,RRS
R4516 T6601 T6602 compound incision,excision
R4517 T6602 T6593 compound excision,activity
R4518 T6603 T6602 punct /,excision
R4519 T6604 T6588 punct .,sensitivity
R452 T784 T783 prep of,one
R4520 T6606 T6607 nmod UV,survival
R4521 T6607 T6608 nmod survival,assays
R4522 T6608 T6618 nsubjpass assays,performed
R4523 T6609 T6607 punct ", ",survival
R4524 T6610 T6611 compound UV,UDS
R4525 T6611 T6607 conj UDS,survival
R4526 T6612 T6611 punct -,UDS
R4527 T6613 T6611 punct ", ",UDS
R4528 T6614 T6611 cc and,UDS
R4529 T6615 T6616 compound UV,RRS
R453 T785 T786 det the,components
R4530 T6616 T6611 conj RRS,UDS
R4531 T6617 T6616 punct -,RRS
R4532 T6619 T6618 auxpass were,performed
R4533 T6620 T6621 mark as,described
R4534 T6621 T6618 advcl described,performed
R4535 T6622 T6621 advmod previously,described
R4536 T6623 T6624 punct [,30
R4537 T6624 T6618 parataxis 30,performed
R4538 T6625 T6624 nummod 21,30
R4539 T6626 T6624 punct ",",30
R454 T786 T784 pobj components,of
R4540 T6627 T6624 punct ],30
R4541 T6628 T6618 punct .,performed
R4542 T6630 T6631 prep For,presented
R4543 T6632 T6633 compound UV,RRS
R4544 T6633 T6630 pobj RRS,For
R4545 T6634 T6633 punct -,RRS
R4546 T6635 T6631 punct ", ",presented
R4547 T6636 T6637 amod average,values
R4548 T6637 T6631 nsubjpass values,presented
R4549 T6638 T6637 prep from,values
R455 T787 T786 nummod two,components
R4550 T6639 T6640 det the,experiment
R4551 T6640 T6638 pobj experiment,from
R4552 T6641 T6640 amod representative,experiment
R4553 T6642 T6640 acl containing,experiment
R4554 T6643 T6644 nummod two,wt
R4555 T6644 T6645 nmod wt,line
R4556 T6645 T6642 dobj line,containing
R4557 T6646 T6644 punct ", ",wt
R4558 T6647 T6648 nummod three,TTD
R4559 T6648 T6644 conj TTD,wt
R456 T788 T786 compound helicase,components
R4560 T6649 T6648 compound XpdTTD,TTD
R4561 T6650 T6648 punct /,TTD
R4562 T6651 T6648 punct ", ",TTD
R4563 T6652 T6653 nummod two,XPCS
R4564 T6653 T6648 conj XPCS,TTD
R4565 T6654 T6653 compound XpdTTD,XPCS
R4566 T6655 T6653 punct /,XPCS
R4567 T6656 T6653 punct ", ",XPCS
R4568 T6657 T6653 cc and,XPCS
R4569 T6658 T6659 nummod one,XP
R457 T789 T786 prep of,components
R4570 T6659 T6653 conj XP,XPCS
R4571 T6660 T6659 compound XpdTTD,XP
R4572 T6661 T6659 punct /,XP
R4573 T6662 T6645 compound cell,line
R4574 T6663 T6631 auxpass are,presented
R4575 T6664 T6631 punct .,presented
R4576 T6666 T6667 det The,value
R4577 T6667 T6674 nsubj value,differs
R4578 T6668 T6669 punct ~,48
R4579 T6669 T6670 nummod 48,%
R458 T790 T791 amod basal,IIH
R4580 T6670 T6667 compound %,value
R4581 T6671 T6672 compound UV,UDS
R4582 T6672 T6667 compound UDS,value
R4583 T6673 T6672 punct -,UDS
R4584 T6675 T6667 acl presented,value
R4585 T6676 T6675 prep in,presented
R4586 T6677 T6678 det this,study
R4587 T6678 T6676 pobj study,in
R4588 T6679 T6667 prep for,value
R4589 T6680 T6681 compound XpdTTD,TTD
R459 T791 T789 pobj IIH,of
R4590 T6681 T6683 compound TTD,cells
R4591 T6682 T6681 punct /,TTD
R4592 T6683 T6679 pobj cells,for
R4593 T6684 T6674 prep from,differs
R4594 T6685 T6686 poss our,data
R4595 T6686 T6684 pobj data,from
R4596 T6687 T6688 advmod previously,published
R4597 T6688 T6686 amod published,data
R4598 T6689 T6686 prep of,data
R4599 T6690 T6691 nummod 25,%
R460 T792 T791 nmod transcription,IIH
R4600 T6691 T6692 compound %,UDS
R4601 T6692 T6689 pobj UDS,of
R4602 T6693 T6692 compound UV,UDS
R4603 T6694 T6692 punct -,UDS
R4604 T6695 T6696 punct [,21
R4605 T6696 T6674 parataxis 21,differs
R4606 T6697 T6696 punct ],21
R4607 T6698 T6674 punct ", ",differs
R4608 T6699 T6700 advmod possibly,because
R4609 T6700 T6674 prep because,differs
R461 T793 T792 punct /,transcription
R4610 T6701 T6700 prep of,because
R4611 T6702 T6703 det the,variability
R4612 T6703 T6701 pobj variability,of
R4613 T6704 T6703 amod high,variability
R4614 T6705 T6703 amod intrinsic,variability
R4615 T6706 T6705 prep to,intrinsic
R4616 T6707 T6708 det the,assay
R4617 T6708 T6706 pobj assay,to
R4618 T6709 T6708 cc or,assay
R4619 T6710 T6711 amod routine,variations
R462 T794 T795 compound DNA,repair
R4620 T6711 T6708 conj variations,assay
R4621 T6712 T6708 prep in,assay
R4622 T6713 T6714 det the,conditions
R4623 T6714 T6712 pobj conditions,in
R4624 T6715 T6716 compound cell,culture
R4625 T6716 T6714 compound culture,conditions
R4626 T6717 T6674 punct .,differs
R4627 T6719 T6720 prep For,prepared
R4628 T6721 T6722 det the,assay
R4629 T6722 T6719 pobj assay,For
R463 T795 T792 appos repair,transcription
R4630 T6723 T6724 compound incision,excision
R4631 T6724 T6722 compound excision,assay
R4632 T6725 T6724 punct /,excision
R4633 T6726 T6722 compound activity,assay
R4634 T6727 T6720 punct ", ",prepared
R4635 T6728 T6729 amod recombinant,TFIIH
R4636 T6729 T6720 nsubjpass TFIIH,prepared
R4637 T6730 T6720 auxpass was,prepared
R4638 T6731 T6720 cc and,prepared
R4639 T6732 T6720 conj assayed,prepared
R464 T796 T791 compound factor,IIH
R4640 T6733 T6734 mark as,described
R4641 T6734 T6732 advcl described,assayed
R4642 T6735 T6734 advmod previously,described
R4643 T6736 T6737 punct [,27
R4644 T6737 T6732 parataxis 27,assayed
R4645 T6738 T6737 punct ],27
R4646 T6739 T6720 punct .,prepared
R4649 T6770 T6771 amod Comparative,immunofluorescence
R465 T797 T791 punct (,IIH
R4650 T6772 T6771 punct .,immunofluorescence
R4651 T6774 T6775 compound Latex,labelling
R4652 T6775 T6777 nsubjpass labelling,performed
R4653 T6776 T6775 compound bead,labelling
R4654 T6778 T6775 cc and,labelling
R4655 T6779 T6780 amod comparative,analysis
R4656 T6780 T6775 conj analysis,labelling
R4657 T6781 T6780 compound immunofluorescence,analysis
R4658 T6782 T6780 prep of,analysis
R4659 T6783 T6784 det the,subunit
R466 T798 T791 appos TFIIH,IIH
R4660 T6784 T6782 pobj subunit,of
R4661 T6785 T6784 compound p62,subunit
R4662 T6786 T6784 prep of,subunit
R4663 T6787 T6788 det the,TFIIH
R4664 T6788 T6786 pobj TFIIH,of
R4665 T6789 T6777 auxpass was,performed
R4666 T6790 T6791 mark as,described
R4667 T6791 T6777 advcl described,performed
R4668 T6792 T6791 advmod previously,described
R4669 T6793 T6794 punct [,17
R467 T799 T783 punct ),one
R4670 T6794 T6791 parataxis 17,described
R4671 T6795 T6794 nummod 16,17
R4672 T6796 T6794 punct ",",17
R4673 T6797 T6794 punct ],17
R4674 T6798 T6777 advcl using,performed
R4675 T6799 T6800 amod primary,fibroblasts
R4676 T6800 T6798 dobj fibroblasts,using
R4677 T6801 T6800 nmod mouse,fibroblasts
R4678 T6802 T6800 amod embryonic,fibroblasts
R4679 T6803 T6798 prep at,using
R468 T800 T783 punct ", ",one
R4680 T6804 T6805 nmod passages,2
R4681 T6805 T6803 pobj 2,at
R4682 T6806 T6807 punct –,5
R4683 T6807 T6805 prep 5,2
R4684 T6808 T6777 punct .,performed
R4685 T6810 T6811 nummod Two,lines
R4686 T6811 T6815 nsubjpass lines,used
R4687 T6812 T6810 cc or,Two
R4688 T6813 T6810 conj more,Two
R4689 T6814 T6811 compound cell,lines
R469 T801 T802 det a,complex
R4690 T6816 T6811 prep per,lines
R4691 T6817 T6816 pobj genotype,per
R4692 T6818 T6819 punct (,except
R4693 T6819 T6811 parataxis except,lines
R4694 T6820 T6819 prep for,except
R4695 T6821 T6822 det the,cells
R4696 T6822 T6820 pobj cells,for
R4697 T6823 T6824 compound XpdTTD,†XP
R4698 T6824 T6822 compound †XP,cells
R4699 T6825 T6824 punct /,†XP
R470 T802 T783 appos complex,one
R4700 T6826 T6822 punct ", ",cells
R4701 T6827 T6828 prep in,used
R4702 T6828 T6822 relcl used,cells
R4703 T6829 T6827 pobj which,in
R4704 T6830 T6831 advmod only,line
R4705 T6831 T6828 nsubjpass line,used
R4706 T6832 T6831 nummod one,line
R4707 T6833 T6831 compound cell,line
R4708 T6834 T6828 auxpass was,used
R4709 T6835 T6828 prep in,used
R471 T803 T804 nummod ten,subunit
R4710 T6836 T6837 amod repeated,experiments
R4711 T6837 T6835 pobj experiments,in
R4712 T6838 T6819 punct ),except
R4713 T6839 T6815 auxpass were,used
R4714 T6840 T6815 punct ", ",used
R4715 T6841 T6815 cc and,used
R4716 T6842 T6843 nsubjpass experiments,repeated
R4717 T6843 T6815 conj repeated,used
R4718 T6844 T6843 auxpass were,repeated
R4719 T6845 T6846 compound 2,6
R472 T804 T802 nmod subunit,complex
R4720 T6846 T6848 nummod 6,times
R4721 T6847 T6846 punct –,6
R4722 T6848 T6843 dobj times,repeated
R4723 T6849 T6848 prep per,times
R4724 T6850 T6849 pobj genotype,per
R4725 T6851 T6843 punct .,repeated
R4726 T7096 T7095 prep of,Targeting
R4727 T7097 T7098 det the,Gene
R4728 T7098 T7096 pobj Gene,of
R4729 T7099 T7098 compound Mouse,Gene
R473 T805 T804 punct -,subunit
R4730 T7100 T7098 compound Xpd,Gene
R4731 T7102 T7103 punct (,A
R4732 T7103 T7104 meta A,representation
R4733 T7105 T7103 punct ),A
R4734 T7106 T7104 amod Schematic,representation
R4735 T7107 T7104 prep of,representation
R4736 T7108 T7109 det the,structure
R4737 T7109 T7107 pobj structure,of
R4738 T7110 T7109 amod genomic,structure
R4739 T7111 T7104 cc and,representation
R474 T806 T802 punct ", ",complex
R4740 T7112 T7113 amod partial,map
R4741 T7113 T7104 conj map,representation
R4742 T7114 T7113 compound restriction,map
R4743 T7115 T7113 prep of,map
R4744 T7116 T7117 det the,loci
R4745 T7117 T7115 pobj loci,of
R4746 T7118 T7117 nmod wt,loci
R4747 T7119 T7118 cc and,wt
R4748 T7120 T7118 conj targeted,wt
R4749 T7121 T7117 compound mouse,loci
R475 T807 T802 amod multifunctional,complex
R4750 T7122 T7117 compound Xpd,loci
R4751 T7123 T7113 punct .,map
R4752 T7125 T7126 prep For,represented
R4753 T7127 T7128 det the,allele
R4754 T7128 T7125 pobj allele,For
R4755 T7129 T7128 compound wt,allele
R4756 T7130 T7128 compound Xpd,allele
R4757 T7131 T7126 punct ", ",represented
R4758 T7132 T7133 amod shaded,boxes
R4759 T7133 T7134 nsubj boxes,represent
R476 T808 T809 dep that,is
R4760 T7134 T7126 ccomp represent,represented
R4761 T7135 T7136 amod coding,regions
R4762 T7136 T7134 dobj regions,represent
R4763 T7137 T7136 prep of,regions
R4764 T7138 T7139 nmod exons,12
R4765 T7139 T7137 pobj 12,of
R4766 T7140 T7139 cc and,12
R4767 T7141 T7139 conj 19,12
R4768 T7142 T7143 punct –,23
R4769 T7143 T7141 prep 23,19
R477 T809 T802 relcl is,complex
R4770 T7144 T7126 punct ;,represented
R4771 T7145 T7146 det the,UTR
R4772 T7146 T7126 nsubjpass UTR,represented
R4773 T7147 T7146 nummod 3,UTR
R4774 T7148 T7147 punct ′,3
R4775 T7149 T7126 auxpass is,represented
R4776 T7150 T7126 agent by,represented
R4777 T7151 T7152 det an,box
R4778 T7152 T7150 pobj box,by
R4779 T7153 T7152 amod open,box
R478 T810 T809 acomp essential,is
R4780 T7154 T7126 punct .,represented
R4781 T7156 T7157 nsubj TGA,indicates
R4782 T7157 T7158 ccomp indicates,indicates
R4783 T7159 T7160 det the,codon
R4784 T7160 T7157 dobj codon,indicates
R4785 T7161 T7160 amod translational,codon
R4786 T7162 T7160 compound stop,codon
R4787 T7163 T7158 punct ;,indicates
R4788 T7164 T7158 nsubj PolyA,indicates
R4789 T7165 T7166 det the,signal
R479 T811 T810 prep for,essential
R4790 T7166 T7158 dobj signal,indicates
R4791 T7167 T7166 compound polyadenylation,signal
R4792 T7168 T7158 punct .,indicates
R4793 T7170 T7171 prep For,indicated
R4794 T7172 T7173 det the,allele
R4795 T7173 T7170 pobj allele,For
R4796 T7174 T7173 nmod XpdTTD,allele
R4797 T7175 T7173 amod targeted,allele
R4798 T7176 T7171 punct ", ",indicated
R4799 T7177 T7178 det the,fragment
R480 T812 T813 amod multiple,processes
R4800 T7178 T7171 nsubjpass fragment,indicated
R4801 T7179 T7180 nummod 194,pair
R4802 T7180 T7178 nmod pair,fragment
R4803 T7181 T7180 punct –,pair
R4804 T7182 T7180 nmod base,pair
R4805 T7183 T7180 punct (,pair
R4806 T7184 T7180 appos bp,pair
R4807 T7185 T7178 punct ),fragment
R4808 T7186 T7178 amod human,fragment
R4809 T7187 T7178 compound XPD,fragment
R481 T813 T811 pobj processes,for
R4810 T7188 T7178 compound cDNA,fragment
R4811 T7189 T7178 acl fused,fragment
R4812 T7190 T7189 prep to,fused
R4813 T7191 T7190 pobj exon,to
R4814 T7192 T7191 nummod 22,exon
R4815 T7193 T7171 auxpass is,indicated
R4816 T7194 T7171 prep as,indicated
R4817 T7195 T7196 det a,box
R4818 T7196 T7194 pobj box,as
R4819 T7197 T7196 amod striped,box
R482 T814 T813 punct ", ",processes
R4820 T7198 T7171 prep including,indicated
R4821 T7199 T7200 det the,mutation
R4822 T7200 T7198 pobj mutation,including
R4823 T7201 T7200 nmod TTD,mutation
R4824 T7202 T7203 punct (,R722W
R4825 T7203 T7201 parataxis R722W,TTD
R4826 T7204 T7203 punct ),R722W
R4827 T7205 T7200 acl indicated,mutation
R4828 T7206 T7205 agent by,indicated
R4829 T7207 T7208 det a,arrow
R483 T815 T813 prep including,processes
R4830 T7208 T7206 pobj arrow,by
R4831 T7209 T7208 amod vertical,arrow
R4832 T7210 T7171 punct .,indicated
R4833 T7212 T7213 nmod Chicken,2
R4834 T7213 T7218 nsubjpass 2,indicated
R4835 T7214 T7215 nmod β,globin
R4836 T7215 T7213 nmod globin,2
R4837 T7216 T7215 punct -,globin
R4838 T7217 T7213 nmod exons,2
R4839 T7219 T7213 cc and,2
R484 T816 T817 amod basal,initiation
R4840 T7220 T7213 conj 3,2
R4841 T7221 T7213 prep including,2
R4842 T7222 T7223 det the,UTR
R4843 T7223 T7221 pobj UTR,including
R4844 T7224 T7223 nummod 3,UTR
R4845 T7225 T7224 punct ′,3
R4846 T7226 T7218 auxpass are,indicated
R4847 T7227 T7218 prep as,indicated
R4848 T7228 T7229 amod black,boxes
R4849 T7229 T7227 pobj boxes,as
R485 T817 T815 pobj initiation,including
R4850 T7230 T7229 prep with,boxes
R4851 T7231 T7232 amod corresponding,numerals
R4852 T7232 T7230 pobj numerals,with
R4853 T7233 T7232 compound Roman,numerals
R4854 T7234 T7232 acl followed,numerals
R4855 T7235 T7234 agent by,followed
R4856 T7236 T7237 det the,signal
R4857 T7237 T7235 pobj signal,by
R4858 T7238 T7239 compound β,globin
R4859 T7239 T7237 compound globin,signal
R486 T818 T817 compound transcription,initiation
R4860 T7240 T7239 punct -,globin
R4861 T7241 T7237 compound polyadenylation,signal
R4862 T7242 T7243 punct (,PolyA*
R4863 T7243 T7237 parataxis PolyA*,signal
R4864 T7244 T7243 punct ),PolyA*
R4865 T7245 T7218 punct .,indicated
R4866 T7247 T7248 prep For,indicate
R4867 T7249 T7250 det the,alleles
R4868 T7250 T7247 pobj alleles,For
R4869 T7251 T7250 nmod Xpd†XP,alleles
R487 T819 T817 cc and,initiation
R4870 T7252 T7251 cc and,Xpd†XP
R4871 T7253 T7251 conj Xpd†XPCS,Xpd†XP
R4872 T7254 T7250 amod targeted,alleles
R4873 T7255 T7248 punct ", ",indicate
R4874 T7256 T7257 amod vertical,arrows
R4875 T7257 T7248 nsubj arrows,indicate
R4876 T7258 T7259 nmod XPCS,mutations
R4877 T7259 T7248 dobj mutations,indicate
R4878 T7260 T7261 punct (,encoding
R4879 T7261 T7258 parataxis encoding,XPCS
R488 T820 T821 compound DNA,repair
R4880 T7262 T7261 npadvmod G602D,encoding
R4881 T7263 T7261 punct -,encoding
R4882 T7264 T7261 punct ),encoding
R4883 T7265 T7258 cc and,XPCS
R4884 T7266 T7258 conj XP,XPCS
R4885 T7267 T7268 punct (,encoding
R4886 T7268 T7266 parataxis encoding,XP
R4887 T7269 T7268 npadvmod R683W,encoding
R4888 T7270 T7268 punct -,encoding
R4889 T7271 T7268 punct ),encoding
R489 T821 T817 conj repair,initiation
R4890 T7272 T7259 prep in,mutations
R4891 T7273 T7274 nmod exons,19
R4892 T7274 T7272 pobj 19,in
R4893 T7275 T7274 cc and,19
R4894 T7276 T7274 conj 22,19
R4895 T7277 T7248 punct ", ",indicate
R4896 T7278 T7248 advmod respectively,indicate
R4897 T7279 T7248 punct .,indicate
R4898 T7281 T7282 det The,probe
R4899 T7282 T7286 nsubjpass probe,marked
R490 T822 T821 compound damage,repair
R4900 T7283 T7282 amod unique,probe
R4901 T7284 T7282 nummod 3,probe
R4902 T7285 T7284 punct ′,3
R4903 T7287 T7282 acl located,probe
R4904 T7288 T7287 prep outside,located
R4905 T7289 T7290 det the,construct
R4906 T7290 T7288 pobj construct,outside
R4907 T7291 T7290 amod targeting,construct
R4908 T7292 T7286 auxpass is,marked
R4909 T7293 T7286 agent by,marked
R491 T823 T821 prep via,repair
R4910 T7294 T7295 det a,line
R4911 T7295 T7293 pobj line,by
R4912 T7296 T7295 amod thick,line
R4913 T7297 T7295 amod black,line
R4914 T7298 T7286 punct .,marked
R4915 T7300 T7301 compound Restriction,sites
R4916 T7302 T7301 punct : ,sites
R4917 T7303 T7301 appos B,sites
R4918 T7304 T7303 punct ", ",B
R4919 T7305 T7303 appos BamHI,B
R492 T824 T825 det the,pathway
R4920 T7306 T7303 punct ;,B
R4921 T7307 T7303 appos C,B
R4922 T7308 T7307 punct ", ",C
R4923 T7309 T7307 appos ClaI,C
R4924 T7310 T7303 punct ;,B
R4925 T7311 T7303 appos E,B
R4926 T7312 T7311 punct ", ",E
R4927 T7313 T7311 appos EcoRI,E
R4928 T7314 T7303 punct ;,B
R4929 T7315 T7303 appos H,B
R493 T825 T823 pobj pathway,via
R4930 T7316 T7315 punct ", ",H
R4931 T7317 T7315 appos HindIII,H
R4932 T7318 T7303 punct ;,B
R4933 T7319 T7303 appos Hp,B
R4934 T7320 T7319 punct ", ",Hp
R4935 T7321 T7319 appos HpaI,Hp
R4936 T7322 T7303 punct ;,B
R4937 T7323 T7303 appos Sf,B
R4938 T7324 T7323 punct ", ",Sf
R4939 T7325 T7323 appos SfiI,Sf
R494 T826 T827 nmod nucleotide,repair
R4940 T7326 T7301 punct .,sites
R4941 T7328 T7329 punct (,B
R4942 T7329 T7330 meta B,analysis
R4943 T7331 T7329 punct ),B
R4944 T7332 T7333 compound Southern,blot
R4945 T7333 T7330 compound blot,analysis
R4946 T7334 T7330 prep of,analysis
R4947 T7335 T7336 npadvmod EcoRI,digested
R4948 T7336 T7338 amod digested,DNA
R4949 T7337 T7336 punct -,digested
R495 T827 T825 nmod repair,pathway
R4950 T7338 T7334 pobj DNA,of
R4951 T7339 T7338 amod genomic,DNA
R4952 T7340 T7338 prep from,DNA
R4953 T7341 T7342 nmod wt,clones
R4954 T7342 T7340 pobj clones,from
R4955 T7343 T7341 punct ", ",wt
R4956 T7344 T7345 compound Xpd†XPCS,wt
R4957 T7345 T7341 conj wt,wt
R4958 T7346 T7345 punct /,wt
R4959 T7347 T7345 punct ", ",wt
R496 T828 T827 nmod excision,repair
R4960 T7348 T7345 cc and,wt
R4961 T7349 T7350 compound Xpd†XP,wt
R4962 T7350 T7345 conj wt,wt
R4963 T7351 T7350 punct /,wt
R4964 T7352 T7342 amod recombinant,clones
R4965 T7353 T7354 amod embryonic,cell
R4966 T7354 T7342 compound cell,clones
R4967 T7355 T7354 compound stem,cell
R4968 T7356 T7342 acl hybridised,clones
R4969 T7357 T7356 prep with,hybridised
R497 T829 T827 punct (,repair
R4970 T7358 T7359 det the,probe
R4971 T7359 T7357 pobj probe,with
R4972 T7360 T7359 nummod 3,probe
R4973 T7361 T7360 punct ′,3
R4974 T7362 T7359 acl depicted,probe
R4975 T7363 T7362 prep in,depicted
R4976 T7364 T7363 punct (,in
R4977 T7365 T7363 pobj A,in
R4978 T7366 T7330 punct ),analysis
R4979 T7367 T7330 punct .,analysis
R498 T830 T827 appos NER,repair
R4980 T7369 T7370 det The,allele
R4981 T7370 T7372 nsubj allele,yields
R4982 T7371 T7370 compound wt,allele
R4983 T7373 T7374 det a,fragment
R4984 T7374 T7372 dobj fragment,yields
R4985 T7375 T7376 nummod 6.5,kilobase
R4986 T7376 T7374 nmod kilobase,fragment
R4987 T7377 T7376 punct -,kilobase
R4988 T7378 T7376 punct (,kilobase
R4989 T7379 T7376 appos kb,kilobase
R499 T831 T825 punct ),pathway
R4990 T7380 T7374 punct ),fragment
R4991 T7381 T7372 punct ", ",yields
R4992 T7382 T7383 mark whereas,yield
R4993 T7383 T7372 advcl yield,yields
R4994 T7384 T7385 preconj both,alleles
R4995 T7385 T7383 nsubj alleles,yield
R4996 T7386 T7385 amod targeted,alleles
R4997 T7387 T7385 nmod Xpd†XP,alleles
R4998 T7388 T7387 cc and,Xpd†XP
R4999 T7389 T7387 conj Xpd†XPCS,Xpd†XP
R500 T832 T833 punct [,7
R5000 T7390 T7391 det a,fragment
R5001 T7391 T7383 dobj fragment,yield
R5002 T7392 T7393 nummod 5.1,kb
R5003 T7393 T7391 compound kb,fragment
R5004 T7394 T7393 punct -,kb
R5005 T7395 T7372 punct .,yields
R5006 T7397 T7398 punct (,C
R5007 T7398 T7399 meta C,Genotyping
R5008 T7400 T7398 punct ),C
R5009 T7401 T7399 prep of,Genotyping
R501 T833 T783 parataxis 7,one
R5010 T7402 T7403 nmod wt,alleles
R5011 T7403 T7401 pobj alleles,of
R5012 T7404 T7402 cc and,wt
R5013 T7405 T7402 conj targeted,wt
R5014 T7406 T7399 prep by,Genotyping
R5015 T7407 T7406 pobj PCR,by
R5016 T7408 T7399 acl using,Genotyping
R5017 T7409 T7408 dobj primers,using
R5018 T7410 T7409 appos F2,primers
R5019 T7411 T7410 punct ", ",F2
R502 T834 T833 nummod 6,7
R5020 T7412 T7410 conj R1,F2
R5021 T7413 T7412 punct ", ",R1
R5022 T7414 T7412 cc and,R1
R5023 T7415 T7412 conj mR,R1
R5024 T7416 T7417 mark as,indicated
R5025 T7417 T7408 advcl indicated,using
R5026 T7418 T7408 prep in,using
R5027 T7419 T7420 punct (,A
R5028 T7420 T7421 meta A,fragments
R5029 T7421 T7418 pobj fragments,in
R503 T835 T833 punct ",",7
R5030 T7422 T7420 punct ),A
R5031 T7423 T7421 nmod yields,fragments
R5032 T7424 T7421 prep of,fragments
R5033 T7425 T7426 nummod 399,bp
R5034 T7426 T7424 pobj bp,of
R5035 T7427 T7426 cc and,bp
R5036 T7428 T7429 nummod 468,bp
R5037 T7429 T7426 conj bp,bp
R5038 T7430 T7408 punct ", ",using
R5039 T7431 T7408 advmod respectively,using
R504 T836 T833 punct ],7
R5040 T7432 T7399 punct .,Genotyping
R5041 T7434 T7435 punct (,D
R5042 T7435 T7436 meta D,results
R5043 T7437 T7435 punct ),D
R5044 T7438 T7439 compound RT,PCR
R5045 T7439 T7441 compound PCR,detection
R5046 T7440 T7439 punct -,PCR
R5047 T7441 T7436 nsubj detection,results
R5048 T7442 T7441 prep of,detection
R5049 T7443 T7444 compound mRNA,expression
R505 T837 T782 punct .,encodes
R5050 T7444 T7442 pobj expression,of
R5051 T7445 T7444 acl originating,expression
R5052 T7446 T7445 prep from,originating
R5053 T7447 T7448 det the,alleles
R5054 T7448 T7446 pobj alleles,from
R5055 T7449 T7448 amod targeted,alleles
R5056 T7450 T7448 nmod †XP,alleles
R5057 T7451 T7450 cc and,†XP
R5058 T7452 T7450 conj †XPCS,†XP
R5059 T7453 T7441 prep in,detection
R506 T839 T840 nsubjpass Alterations,associated
R5060 T7454 T7455 amod embryonic,cell
R5061 T7455 T7457 compound cell,clones
R5062 T7456 T7455 compound stem,cell
R5063 T7457 T7453 pobj clones,in
R5064 T7458 T7441 acl using,detection
R5065 T7459 T7458 dobj primers,using
R5066 T7460 T7459 appos F1,primers
R5067 T7461 T7462 punct (,hybridising
R5068 T7462 T7460 parataxis hybridising,F1
R5069 T7463 T7462 prep outside,hybridising
R507 T841 T839 prep in,Alterations
R5070 T7464 T7465 det the,construct
R5071 T7465 T7463 pobj construct,outside
R5072 T7466 T7465 amod targeting,construct
R5073 T7467 T7462 punct ),hybridising
R5074 T7468 T7460 cc and,F1
R5075 T7469 T7460 conj mR,F1
R5076 T7470 T7471 mark as,indicated
R5077 T7471 T7458 advcl indicated,using
R5078 T7472 T7471 prep in,indicated
R5079 T7473 T7472 punct (,in
R508 T842 T841 pobj XPD,in
R5080 T7474 T7472 pobj A,in
R5081 T7475 T7436 punct ),results
R5082 T7476 T7436 prep in,results
R5083 T7477 T7478 det a,fragment
R5084 T7478 T7476 pobj fragment,in
R5085 T7479 T7480 nummod "1,416",bp
R5086 T7480 T7478 compound bp,fragment
R5087 T7481 T7480 punct -,bp
R5088 T7482 T7436 punct .,results
R5089 T7484 T7485 punct (,E
R509 T843 T839 acl resulting,Alterations
R5090 T7485 T7486 meta E,analysis
R5091 T7487 T7485 punct ),E
R5092 T7488 T7489 compound Northern,blot
R5093 T7489 T7486 compound blot,analysis
R5094 T7490 T7486 prep of,analysis
R5095 T7491 T7492 amod total,RNA
R5096 T7492 T7490 pobj RNA,of
R5097 T7493 T7492 acl isolated,RNA
R5098 T7494 T7493 prep from,isolated
R5099 T7495 T7494 pobj testis,from
R510 T844 T843 prep in,resulting
R5100 T7496 T7495 prep of,testis
R5101 T7497 T7498 amod homozygous,wt
R5102 T7498 T7499 nmod wt,mice
R5103 T7499 T7496 pobj mice,of
R5104 T7500 T7498 cc and,wt
R5105 T7501 T7502 compound XpdTTD,TTD
R5106 T7502 T7498 conj TTD,wt
R5107 T7503 T7502 punct /,TTD
R5108 T7504 T7498 punct ", ",wt
R5109 T7505 T7506 amod heterozygous,wt
R511 T845 T846 amod defective,function
R5110 T7506 T7498 conj wt,wt
R5111 T7507 T7506 compound Xpd†XPCS,wt
R5112 T7508 T7506 punct /,wt
R5113 T7509 T7506 cc and,wt
R5114 T7510 T7511 compound XpdTTD,wt
R5115 T7511 T7506 conj wt,wt
R5116 T7512 T7511 punct /,wt
R5117 T7513 T7506 punct ", ",wt
R5118 T7514 T7506 cc and,wt
R5119 T7515 T7516 amod compound,TTD
R512 T846 T844 pobj function,in
R5120 T7516 T7506 conj TTD,wt
R5121 T7517 T7516 amod heterozygous,TTD
R5122 T7518 T7516 compound Xpd†XPCS,TTD
R5123 T7519 T7516 punct /,TTD
R5124 T7520 T7521 mark as,indicated
R5125 T7521 T7493 advcl indicated,isolated
R5126 T7522 T7486 punct .,analysis
R5127 T7524 T7525 nsubj Hybridisation,detects
R5128 T7526 T7524 prep with,Hybridisation
R5129 T7527 T7528 det a,probe
R513 T847 T846 compound TFIIH,function
R5130 T7528 T7526 pobj probe,with
R5131 T7529 T7530 nummod 1.4,kb
R5132 T7530 T7528 compound kb,probe
R5133 T7531 T7530 punct -,kb
R5134 T7532 T7528 compound mouse,probe
R5135 T7533 T7528 compound Xpd,probe
R5136 T7534 T7528 compound cDNA,probe
R5137 T7535 T7525 dobj mRNAs,detects
R5138 T7536 T7535 prep of,mRNAs
R5139 T7537 T7538 nummod 4,kb
R514 T848 T840 auxpass are,associated
R5140 T7538 T7536 pobj kb,of
R5141 T7539 T7537 punct ", ",4
R5142 T7540 T7537 conj 3.3,4
R5143 T7541 T7540 punct ", ",3.3
R5144 T7542 T7540 cc and,3.3
R5145 T7543 T7540 conj 2.7,3.3
R5146 T7544 T7535 prep from,mRNAs
R5147 T7545 T7546 nmod wt,alleles
R5148 T7546 T7544 pobj alleles,from
R5149 T7547 T7545 punct ", ",wt
R515 T849 T840 prep with,associated
R5150 T7548 T7545 conj Xpd†XPCS,wt
R5151 T7549 T7548 punct ", ",Xpd†XPCS
R5152 T7550 T7548 cc and,Xpd†XPCS
R5153 T7551 T7548 conj XpdTTD,Xpd†XPCS
R5154 T7552 T7535 punct ", ",mRNAs
R5155 T7553 T7535 advmod respectively,mRNAs
R5156 T7554 T7525 punct .,detects
R5157 T7556 T7557 det An,gel
R5158 T7557 T7565 nsubjpass gel,shown
R5159 T7558 T7559 compound ethidium,bromide
R516 T850 T851 npadvmod UV,sensitive
R5160 T7559 T7560 npadvmod bromide,stained
R5161 T7560 T7557 amod stained,gel
R5162 T7561 T7559 punct (,bromide
R5163 T7562 T7559 appos EtBr,bromide
R5164 T7563 T7560 punct ),stained
R5165 T7564 T7560 punct –,stained
R5166 T7566 T7557 acl showing,gel
R5167 T7567 T7568 det the,amount
R5168 T7568 T7566 dobj amount,showing
R5169 T7569 T7568 prep of,amount
R517 T851 T853 amod sensitive,disorders
R5170 T7570 T7571 amod total,RNA
R5171 T7571 T7569 pobj RNA,of
R5172 T7572 T7571 acl loaded,RNA
R5173 T7573 T7565 auxpass is,shown
R5174 T7574 T7565 advmod below,shown
R5175 T7575 T7565 punct .,shown
R5176 T7658 T7659 amod Partial,Rescue
R5177 T7660 T7659 prep of,Rescue
R5178 T7661 T7660 pobj TTD,of
R5179 T7662 T7661 amod Cutaneous,TTD
R518 T852 T851 punct -,sensitive
R5180 T7663 T7661 punct ", ",TTD
R5181 T7664 T7661 conj Blood,TTD
R5182 T7665 T7664 punct ", ",Blood
R5183 T7666 T7664 cc and,Blood
R5184 T7667 T7668 amod Developmental,Phenotypes
R5185 T7668 T7664 conj Phenotypes,Blood
R5186 T7669 T7659 prep in,Rescue
R5187 T7670 T7671 nmod Compound,Mice
R5188 T7671 T7669 pobj Mice,in
R5189 T7672 T7671 amod Heterozygous,Mice
R519 T853 T849 pobj disorders,with
R5190 T7673 T7674 compound XpdTTD,†XPCS
R5191 T7674 T7671 compound †XPCS,Mice
R5192 T7675 T7674 punct /,†XPCS
R5193 T7677 T7678 punct (,A
R5194 T7678 T7679 meta A,Photographs
R5195 T7680 T7678 punct ),A
R5196 T7681 T7679 prep of,Photographs
R5197 T7682 T7683 nummod 5,mo
R5198 T7683 T7685 npadvmod mo,old
R5199 T7684 T7683 punct -,mo
R520 T854 T853 punct ", ",disorders
R5200 T7685 T7687 amod old,mice
R5201 T7686 T7685 punct -,old
R5202 T7687 T7681 pobj mice,of
R5203 T7688 T7689 amod homozygous,TTD
R5204 T7689 T7687 nmod TTD,mice
R5205 T7690 T7689 nmod XpdTTD,TTD
R5206 T7691 T7689 punct /,TTD
R5207 T7692 T7689 punct ", ",TTD
R5208 T7693 T7694 nmod compound,†XPCS
R5209 T7694 T7689 conj †XPCS,TTD
R521 T855 T853 amod multisystem,disorders
R5210 T7695 T7694 amod heterozygous,†XPCS
R5211 T7696 T7694 compound XpdTTD,†XPCS
R5212 T7697 T7694 punct /,†XPCS
R5213 T7698 T7694 punct ", ",†XPCS
R5214 T7699 T7694 cc and,†XPCS
R5215 T7700 T7694 conj wt,†XPCS
R5216 T7701 T7679 punct .,Photographs
R5217 T7704 T7703 punct : ,Insets
R5218 T7705 T7703 appos images,Insets
R5219 T7706 T7705 prep of,images
R522 T856 T853 prep including,disorders
R5220 T7707 T7708 amod first,round
R5221 T7708 T7710 compound round,loss
R5222 T7709 T7708 punct -,round
R5223 T7710 T7706 pobj loss,of
R5224 T7711 T7710 compound hair,loss
R5225 T7712 T7703 punct .,Insets
R5226 T7714 T7715 punct (,B
R5227 T7715 T7716 meta B,analysis
R5228 T7717 T7715 punct ),B
R5229 T7718 T7716 amod Histological,analysis
R523 T857 T858 compound xeroderma,pigmentosum
R5230 T7719 T7716 prep of,analysis
R5231 T7720 T7721 det the,skin
R5232 T7721 T7719 pobj skin,of
R5233 T7722 T7721 prep of,skin
R5234 T7723 T7724 nmod XpdTTD,TTD
R5235 T7724 T7726 nmod TTD,mice
R5236 T7725 T7724 punct /,TTD
R5237 T7726 T7722 pobj mice,of
R5238 T7727 T7724 punct ", ",TTD
R5239 T7728 T7729 compound XpdTTD,†XPCS
R524 T858 T856 pobj pigmentosum,including
R5240 T7729 T7724 conj †XPCS,TTD
R5241 T7730 T7729 punct /,†XPCS
R5242 T7731 T7729 punct ", ",†XPCS
R5243 T7732 T7729 cc and,†XPCS
R5244 T7733 T7729 conj wt,†XPCS
R5245 T7734 T7716 punct .,analysis
R5246 T7736 T7737 npadvmod TTD,associated
R5247 T7737 T7739 amod associated,acanthosis
R5248 T7738 T7737 punct -,associated
R5249 T7739 T7740 nsubj acanthosis,were
R525 T859 T858 punct (,pigmentosum
R5250 T7741 T7742 punct (,epidermis
R5251 T7742 T7739 parataxis epidermis,acanthosis
R5252 T7743 T7742 amod thicker,epidermis
R5253 T7744 T7742 punct ", ",epidermis
R5254 T7745 T7742 acl indicated,epidermis
R5255 T7746 T7745 agent by,indicated
R5256 T7747 T7748 amod solid,line
R5257 T7748 T7746 pobj line,by
R5258 T7749 T7748 amod vertical,line
R5259 T7750 T7742 punct ),epidermis
R526 T860 T858 appos XP,pigmentosum
R5260 T7751 T7739 punct ", ",acanthosis
R5261 T7752 T7753 amod pronounced,layer
R5262 T7753 T7739 conj layer,acanthosis
R5263 T7754 T7753 amod granular,layer
R5264 T7755 T7753 punct (,layer
R5265 T7756 T7753 acl indicated,layer
R5266 T7757 T7756 agent by,indicated
R5267 T7758 T7757 pobj arrows,by
R5268 T7759 T7753 punct ),layer
R5269 T7760 T7753 punct ", ",layer
R527 T861 T858 punct ),pigmentosum
R5270 T7761 T7753 cc and,layer
R5271 T7762 T7763 amod sebacious,hyperplasia
R5272 T7763 T7753 conj hyperplasia,layer
R5273 T7764 T7763 compound gland,hyperplasia
R5274 T7765 T7763 punct (,hyperplasia
R5275 T7766 T7763 acl indicated,hyperplasia
R5276 T7767 T7766 agent by,indicated
R5277 T7768 T7769 amod dotted,line
R5278 T7769 T7767 pobj line,by
R5279 T7770 T7769 amod vertical,line
R528 T862 T858 punct ", ",pigmentosum
R5280 T7771 T7740 punct ),were
R5281 T7772 T7740 acomp absent,were
R5282 T7773 T7740 prep in,were
R5283 T7774 T7775 det the,epidermis
R5284 T7775 T7773 pobj epidermis,in
R5285 T7776 T7775 prep of,epidermis
R5286 T7777 T7778 nmod XpdTTD,†XPCS
R5287 T7778 T7780 nmod †XPCS,mice
R5288 T7779 T7778 punct /,†XPCS
R5289 T7780 T7776 pobj mice,of
R529 T863 T858 conj XP,pigmentosum
R5290 T7781 T7778 cc and,†XPCS
R5291 T7782 T7778 conj wt,†XPCS
R5292 T7783 T7740 punct .,were
R5293 T7786 T7785 appos 400,Magnification
R5294 T7787 T7786 punct ×,400
R5295 T7788 T7785 punct .,Magnification
R5296 T7790 T7791 punct (,C
R5297 T7791 T7792 meta C,content
R5298 T7793 T7791 punct ),C
R5299 T7794 T7792 compound Cysteine,content
R530 T864 T863 acl combined,XP
R5300 T7795 T7792 prep of,content
R5301 T7796 T7795 pobj hair,of
R5302 T7797 T7796 prep from,hair
R5303 T7798 T7799 nmod wt,mice
R5304 T7799 T7797 pobj mice,from
R5305 T7800 T7798 punct ", ",wt
R5306 T7801 T7802 compound XpdTTD,TTD
R5307 T7802 T7798 conj TTD,wt
R5308 T7803 T7802 punct /,TTD
R5309 T7804 T7802 punct ", ",TTD
R531 T865 T864 prep with,combined
R5310 T7805 T7802 cc and,TTD
R5311 T7806 T7807 compound XpdTTD,†XPCS
R5312 T7807 T7802 conj †XPCS,TTD
R5313 T7808 T7807 punct /,†XPCS
R5314 T7809 T7792 punct .,content
R5315 T7811 T7812 det The,value
R5316 T7812 T7815 nsubj value,indicates
R5317 T7813 T7812 compound p,value
R5318 T7814 T7812 punct -,value
R5319 T7816 T7817 amod significant,differences
R532 T866 T867 compound Cockayne,syndrome
R5320 T7817 T7815 dobj differences,indicates
R5321 T7818 T7817 prep between,differences
R5322 T7819 T7818 pobj mutants,between
R5323 T7820 T7819 cc and,mutants
R5324 T7821 T7819 conj wt,mutants
R5325 T7822 T7818 punct ", ",between
R5326 T7823 T7824 advmod as,as
R5327 T7824 T7818 cc as,between
R5328 T7825 T7824 advmod well,as
R5329 T7826 T7818 conj between,between
R533 T867 T865 pobj syndrome,with
R5330 T7827 T7828 nmod XpdTTD,TTD
R5331 T7828 T7830 nmod TTD,mice
R5332 T7829 T7828 punct /,TTD
R5333 T7830 T7826 pobj mice,between
R5334 T7831 T7828 cc and,TTD
R5335 T7832 T7833 compound XpdTTD,†XPCS
R5336 T7833 T7828 conj †XPCS,TTD
R5337 T7834 T7833 punct /,†XPCS
R5338 T7835 T7815 punct .,indicates
R5339 T7837 T7838 compound Error,bars
R534 T868 T867 punct (,syndrome
R5340 T7838 T7839 nsubj bars,indicate
R5341 T7840 T7841 amod standard,error
R5342 T7841 T7839 dobj error,indicate
R5343 T7842 T7841 prep of,error
R5344 T7843 T7844 det the,mean
R5345 T7844 T7842 pobj mean,of
R5346 T7845 T7841 punct (,error
R5347 T7846 T7841 appos SEM,error
R5348 T7847 T7839 punct ),indicate
R5349 T7848 T7839 punct .,indicate
R535 T869 T867 appos CS,syndrome
R5350 T7850 T7851 punct (,D
R5351 T7851 T7852 meta D,values
R5352 T7853 T7851 punct ),D
R5353 T7854 T7852 compound Hematocrit,values
R5354 T7855 T7852 prep from,values
R5355 T7856 T7855 pobj blood,from
R5356 T7857 T7856 prep of,blood
R5357 T7858 T7859 nmod XpdTTD,TTD
R5358 T7859 T7861 nmod TTD,mice
R5359 T7860 T7859 punct /,TTD
R536 T870 T863 punct ),XP
R5360 T7861 T7857 pobj mice,of
R5361 T7862 T7859 cc and,TTD
R5362 T7863 T7864 compound XpdTTD,†XPCS
R5363 T7864 T7859 conj †XPCS,TTD
R5364 T7865 T7864 punct /,†XPCS
R5365 T7866 T7852 punct .,values
R5366 T7868 T7869 det The,values
R5367 T7869 T7872 nsubj values,indicate
R5368 T7870 T7869 compound p,values
R5369 T7871 T7869 punct -,values
R537 T871 T863 punct ", ",XP
R5370 T7873 T7874 det the,significance
R5371 T7874 T7872 dobj significance,indicate
R5372 T7875 T7874 prep of,significance
R5373 T7876 T7877 det the,difference
R5374 T7877 T7875 pobj difference,of
R5375 T7878 T7872 advcl relative,indicate
R5376 T7879 T7878 prep to,relative
R5377 T7880 T7879 pobj wt,to
R5378 T7881 T7872 punct .,indicate
R5379 T7883 T7884 compound Error,bars
R538 T872 T863 cc and,XP
R5380 T7884 T7885 nsubj bars,indicate
R5381 T7886 T7885 dobj SEM,indicate
R5382 T7887 T7885 punct .,indicate
R5383 T7889 T7890 punct (,E
R5384 T7890 T7891 meta E,weights
R5385 T7892 T7890 punct ),E
R5386 T7893 T7891 compound Body,weights
R5387 T7894 T7891 prep of,weights
R5388 T7895 T7896 amod developing,mice
R5389 T7896 T7894 pobj mice,of
R539 T873 T863 conj trichothiodystrophy,XP
R5390 T7897 T7898 nmod XpdTTD,TTD
R5391 T7898 T7896 nmod TTD,mice
R5392 T7899 T7898 punct /,TTD
R5393 T7900 T7898 cc and,TTD
R5394 T7901 T7902 compound XpdTTD,†XPCS
R5395 T7902 T7898 conj †XPCS,TTD
R5396 T7903 T7902 punct /,†XPCS
R5397 T7904 T7896 prep after,mice
R5398 T7905 T7904 pobj weaning,after
R5399 T7906 T7891 acl plotted,weights
R540 T874 T873 punct (,trichothiodystrophy
R5400 T7907 T7906 prep as,plotted
R5401 T7908 T7909 det a,percentage
R5402 T7909 T7907 pobj percentage,as
R5403 T7910 T7909 prep of,percentage
R5404 T7911 T7912 det the,weight
R5405 T7912 T7910 pobj weight,of
R5406 T7913 T7912 prep of,weight
R5407 T7914 T7915 npadvmod age,matched
R5408 T7915 T7917 amod matched,littermates
R5409 T7916 T7915 punct -,matched
R541 T875 T873 appos TTD,trichothiodystrophy
R5410 T7917 T7913 pobj littermates,of
R5411 T7918 T7917 nmod control,littermates
R5412 T7919 T7917 nmod wt,littermates
R5413 T7920 T7919 cc and,wt
R5414 T7921 T7919 conj heterozygote,wt
R5415 T7922 T7923 punct (,hz
R5416 T7923 T7921 parataxis hz,heterozygote
R5417 T7924 T7923 punct ),hz
R5418 T7925 T7926 punct (,set
R5419 T7926 T7909 parataxis set,percentage
R542 T876 T840 punct ),associated
R5420 T7927 T7926 prep at,set
R5421 T7928 T7929 nummod 100,%
R5422 T7929 T7927 pobj %,at
R5423 T7930 T7926 punct ),set
R5424 T7931 T7891 punct .,weights
R5425 T7933 T7934 compound Error,bars
R5426 T7934 T7935 nsubj bars,indicate
R5427 T7936 T7935 dobj SEM,indicate
R5428 T7937 T7935 punct .,indicate
R5429 T8042 T8041 prep of,Rescue
R543 T877 T878 punct [,8
R5430 T8043 T8044 npadvmod TTD,Associated
R5431 T8044 T8046 amod Associated,Features
R5432 T8045 T8044 punct -,Associated
R5433 T8046 T8042 pobj Features,of
R5434 T8047 T8046 amod Segmental,Features
R5435 T8048 T8046 amod Progeroid,Features
R5436 T8049 T8046 prep in,Features
R5437 T8050 T8051 amod Compound,Mice
R5438 T8051 T8049 pobj Mice,in
R5439 T8052 T8051 amod Heterozygous,Mice
R544 T878 T840 parataxis 8,associated
R5440 T8053 T8054 compound Xpd TTD,†XPCS
R5441 T8054 T8051 compound †XPCS,Mice
R5442 T8055 T8054 punct /,†XPCS
R5443 T8057 T8058 punct (,A
R5444 T8058 T8059 meta A,Photographs
R5445 T8060 T8058 punct ),A
R5446 T8061 T8059 prep of,Photographs
R5447 T8062 T8063 nummod 20,mo
R5448 T8063 T8065 npadvmod mo,old
R5449 T8064 T8063 punct -,mo
R545 T879 T880 punct –,10
R5450 T8065 T8067 amod old,mice
R5451 T8066 T8065 punct -,old
R5452 T8067 T8061 pobj mice,of
R5453 T8068 T8067 nmod wt,mice
R5454 T8069 T8068 punct ", ",wt
R5455 T8070 T8071 amod compound,†XPCS
R5456 T8071 T8068 conj †XPCS,wt
R5457 T8072 T8071 amod heterozygous,†XPCS
R5458 T8073 T8071 compound XpdTTD,†XPCS
R5459 T8074 T8071 punct /,†XPCS
R546 T880 T878 prep 10,8
R5460 T8075 T8071 punct ", ",†XPCS
R5461 T8076 T8071 cc and,†XPCS
R5462 T8077 T8078 amod homozygous,TTD
R5463 T8078 T8071 conj TTD,†XPCS
R5464 T8079 T8078 compound XpdTTD,TTD
R5465 T8080 T8078 punct /,TTD
R5466 T8081 T8059 punct .,Photographs
R5467 T8084 T8085 det the,cachexia
R5468 T8085 T8083 dobj cachexia,Note
R5469 T8086 T8085 amod extreme,cachexia
R547 T881 T878 punct ],8
R5470 T8087 T8085 punct (,cachexia
R5471 T8088 T8085 appos lack,cachexia
R5472 T8089 T8088 prep of,lack
R5473 T8090 T8091 amod subcutaneous,fat
R5474 T8091 T8089 pobj fat,of
R5475 T8092 T8085 punct ),cachexia
R5476 T8093 T8085 prep in,cachexia
R5477 T8094 T8095 det the,mouse
R5478 T8095 T8093 pobj mouse,in
R5479 T8096 T8097 compound XpdTTD,TTD
R548 T882 T840 punct .,associated
R5480 T8097 T8095 compound TTD,mouse
R5481 T8098 T8097 punct /,TTD
R5482 T8099 T8083 cc and,Note
R5483 T8100 T8101 det the,absence
R5484 T8101 T8083 conj absence,Note
R5485 T8102 T8101 prep of,absence
R5486 T8103 T8104 det this,phenotype
R5487 T8104 T8102 pobj phenotype,of
R5488 T8105 T8101 prep in,absence
R5489 T8106 T8107 nmod wt,mice
R549 T884 T885 nsubjpass XP,marked
R5490 T8107 T8105 pobj mice,in
R5491 T8108 T8106 cc and,wt
R5492 T8109 T8110 compound XpdTTD,†XPCS
R5493 T8110 T8106 conj †XPCS,wt
R5494 T8111 T8110 punct /,†XPCS
R5495 T8112 T8083 punct .,Note
R5496 T8114 T8115 punct (,B
R5497 T8115 T8116 meta B,Radiographs
R5498 T8117 T8115 punct ),B
R5499 T8118 T8116 prep of,Radiographs
R550 T886 T885 auxpass is,marked
R5500 T8119 T8120 nummod 20,mo
R5501 T8120 T8122 npadvmod mo,old
R5502 T8121 T8120 punct -,mo
R5503 T8122 T8124 amod old,mice
R5504 T8123 T8122 punct -,old
R5505 T8124 T8118 pobj mice,of
R5506 T8125 T8124 amod male,mice
R5507 T8126 T8124 nmod wt,mice
R5508 T8127 T8126 punct ", ",wt
R5509 T8128 T8129 compound XpdTTD,†XPCS
R551 T887 T885 agent by,marked
R5510 T8129 T8126 conj †XPCS,wt
R5511 T8130 T8129 punct /,†XPCS
R5512 T8131 T8129 punct ", ",†XPCS
R5513 T8132 T8129 cc and,†XPCS
R5514 T8133 T8134 compound XpdTTD,TTD
R5515 T8134 T8129 conj TTD,†XPCS
R5516 T8135 T8134 punct /,TTD
R5517 T8136 T8116 punct .,Radiographs
R5518 T8138 T8139 amod Ageing,mice
R5519 T8139 T8143 nsubj mice,develop
R552 T888 T889 npadvmod sun,induced
R5520 T8140 T8141 compound XpdTTD,TTD
R5521 T8141 T8139 compound TTD,mice
R5522 T8142 T8141 punct /,TTD
R5523 T8144 T8143 dobj kyphosis,develop
R5524 T8145 T8144 punct (,kyphosis
R5525 T8146 T8144 appos curvature,kyphosis
R5526 T8147 T8146 prep of,curvature
R5527 T8148 T8149 det the,column
R5528 T8149 T8147 pobj column,of
R5529 T8150 T8149 amod spinal,column
R553 T889 T891 amod induced,anomalies
R5530 T8151 T8144 punct ),kyphosis
R5531 T8152 T8144 cc and,kyphosis
R5532 T8153 T8144 conj reduction,kyphosis
R5533 T8154 T8153 prep of,reduction
R5534 T8155 T8156 compound bone,mineral
R5535 T8156 T8157 compound mineral,density
R5536 T8157 T8154 pobj density,of
R5537 T8158 T8159 mark as,shown
R5538 T8159 T8143 advcl shown,develop
R5539 T8160 T8159 prep in,shown
R554 T890 T889 punct -,induced
R5540 T8161 T8162 det the,segment
R5541 T8162 T8160 pobj segment,in
R5542 T8163 T8164 quantmod 6,8
R5543 T8164 T8162 nummod 8,segment
R5544 T8165 T8164 punct –,8
R5545 T8166 T8162 prep of,segment
R5546 T8167 T8168 det the,vertebrae
R5547 T8168 T8166 pobj vertebrae,of
R5548 T8169 T8168 compound tail,vertebrae
R5549 T8170 T8162 acl counted,segment
R555 T891 T887 pobj anomalies,by
R5550 T8171 T8170 prep from,counted
R5551 T8172 T8173 det the,pelvis
R5552 T8173 T8171 pobj pelvis,from
R5553 T8174 T8175 punct (,see
R5554 T8175 T8143 parataxis see,develop
R5555 T8176 T8175 dobj close,see
R5556 T8177 T8176 punct -,close
R5557 T8178 T8176 prt up,close
R5558 T8179 T8176 prep at,close
R5559 T8180 T8179 pobj right,at
R556 T892 T891 compound pigmentation,anomalies
R5560 T8181 T8175 punct ),see
R5561 T8182 T8143 punct .,develop
R5562 T8185 T8186 det the,absence
R5563 T8186 T8184 dobj absence,Note
R5564 T8187 T8186 prep of,absence
R5565 T8188 T8189 det these,features
R5566 T8189 T8187 pobj features,of
R5567 T8190 T8186 prep in,absence
R5568 T8191 T8192 det the,mouse
R5569 T8192 T8190 pobj mouse,in
R557 T893 T891 cc and,anomalies
R5570 T8193 T8194 compound XpdTTD , † XPCS
R5571 T8194 T8192 compound  † XPCS,mouse
R5572 T8195 T8194 punct /, † XPCS
R5573 T8196 T8184 punct .,Note
R5574 T8198 T8199 punct (,C
R5575 T8199 T8200 meta C,Quantification
R5576 T8201 T8199 punct ),C
R5577 T8202 T8200 prep of,Quantification
R5578 T8203 T8204 amod relative,density
R5579 T8204 T8202 pobj density,of
R558 T894 T895 det a,elevation
R5580 T8205 T8206 compound bone,mineral
R5581 T8206 T8204 compound mineral,density
R5582 T8207 T8204 prep of,density
R5583 T8208 T8209 compound tail,vertebrae
R5584 T8209 T8207 pobj vertebrae,of
R5585 T8210 T8209 prep from,vertebrae
R5586 T8211 T8212 nummod 20,mo
R5587 T8212 T8214 npadvmod mo,old
R5588 T8213 T8212 punct -,mo
R5589 T8214 T8216 amod old,mice
R559 T895 T891 conj elevation,anomalies
R5590 T8215 T8214 punct -,old
R5591 T8216 T8210 pobj mice,from
R5592 T8217 T8216 amod male,mice
R5593 T8218 T8216 nmod wt,mice
R5594 T8219 T8220 punct (,3
R5595 T8220 T8218 parataxis 3,wt
R5596 T8221 T8220 nsubj n,3
R5597 T8222 T8220 punct =,3
R5598 T8223 T8220 punct ),3
R5599 T8224 T8218 punct ", ",wt
R560 T896 T897 amod greater,"1,000"
R5600 T8225 T8226 compound XpdTTD,†XPCS
R5601 T8226 T8218 conj †XPCS,wt
R5602 T8227 T8226 punct /,†XPCS
R5603 T8228 T8229 punct (,4
R5604 T8229 T8226 parataxis 4,†XPCS
R5605 T8230 T8229 nsubj n,4
R5606 T8231 T8229 punct =,4
R5607 T8232 T8229 punct ),4
R5608 T8233 T8226 punct ", ",†XPCS
R5609 T8234 T8226 cc and,†XPCS
R561 T897 T899 quantmod "1,000",fold
R5610 T8235 T8236 compound XpdTTD,TTD
R5611 T8236 T8226 conj TTD,†XPCS
R5612 T8237 T8236 punct /,TTD
R5613 T8238 T8239 punct (,3
R5614 T8239 T8236 parataxis 3,TTD
R5615 T8240 T8239 nsubj n,3
R5616 T8241 T8239 punct =,3
R5617 T8242 T8239 punct ),3
R5618 T8243 T8200 punct .,Quantification
R5619 T8245 T8246 det The,values
R562 T898 T897 quantmod than,"1,000"
R5620 T8246 T8249 nsubj values,indicate
R5621 T8247 T8246 compound p,values
R5622 T8248 T8246 punct -,values
R5623 T8250 T8251 det the,significance
R5624 T8251 T8249 dobj significance,indicate
R5625 T8252 T8251 prep of,significance
R5626 T8253 T8254 det the,difference
R5627 T8254 T8252 pobj difference,of
R5628 T8255 T8249 advcl relative,indicate
R5629 T8256 T8255 prep to,relative
R563 T899 T895 nummod fold,elevation
R5630 T8257 T8258 compound XpdTTD,TTD
R5631 T8258 T8256 pobj TTD,to
R5632 T8259 T8258 punct /,TTD
R5633 T8260 T8249 punct .,indicate
R5634 T8262 T8263 compound Error,bars
R5635 T8263 T8264 nsubj bars,indicate
R5636 T8265 T8264 dobj SEM,indicate
R5637 T8266 T8264 punct .,indicate
R5638 T8268 T8269 punct (,D
R5639 T8269 T8270 meta D,curves
R564 T900 T899 punct -,fold
R5640 T8271 T8269 punct ),D
R5641 T8272 T8273 compound Body,weight
R5642 T8273 T8270 compound weight,curves
R5643 T8274 T8270 prep as,curves
R5644 T8275 T8276 det a,function
R5645 T8276 T8274 pobj function,as
R5646 T8277 T8276 prep of,function
R5647 T8278 T8277 pobj time,of
R5648 T8279 T8270 punct .,curves
R5649 T8282 T8283 mark that,rescued
R565 T901 T895 prep in,elevation
R5650 T8283 T8281 ccomp rescued,Note
R5651 T8284 T8285 det the,cachexia
R5652 T8285 T8283 nsubjpass cachexia,rescued
R5653 T8286 T8287 npadvmod age,dependent
R5654 T8287 T8285 amod dependent,cachexia
R5655 T8288 T8287 punct -,dependent
R5656 T8289 T8285 acl observed,cachexia
R5657 T8290 T8289 prep in,observed
R5658 T8291 T8292 compound XpdTTD,TTD
R5659 T8292 T8294 compound TTD,mice
R566 T902 T903 compound skin,cancer
R5660 T8293 T8292 punct /,TTD
R5661 T8294 T8290 pobj mice,in
R5662 T8295 T8283 auxpass was,rescued
R5663 T8296 T8283 prep in,rescued
R5664 T8297 T8298 preconj both,male
R5665 T8298 T8299 nmod male,mice
R5666 T8299 T8296 pobj mice,in
R5667 T8300 T8298 cc and,male
R5668 T8301 T8298 conj female,male
R5669 T8302 T8303 compound XpdTTD , †XPCS
R567 T903 T904 compound cancer,risk
R5670 T8303 T8299 compound  †XPCS,mice
R5671 T8304 T8303 punct /, †XPCS
R5672 T8305 T8281 punct .,Note
R5673 T8307 T8308 amod Significant,differences
R5674 T8308 T8309 nsubjpass differences,observed
R5675 T8310 T8308 prep between,differences
R5676 T8311 T8310 pobj wt,between
R5677 T8312 T8311 cc and,wt
R5678 T8313 T8314 compound XpdTTD,TTD
R5679 T8314 T8311 conj TTD,wt
R568 T904 T901 pobj risk,in
R5680 T8315 T8314 punct /,TTD
R5681 T8316 T8310 cc but,between
R5682 T8317 T8316 neg not,but
R5683 T8318 T8310 conj between,between
R5684 T8319 T8320 nmod wt,mice
R5685 T8320 T8318 pobj mice,between
R5686 T8321 T8319 cc and,wt
R5687 T8322 T8323 compound XpdTTD,†XPCS
R5688 T8323 T8319 conj †XPCS,wt
R5689 T8324 T8323 punct /,†XPCS
R569 T905 T885 punct .,marked
R5690 T8325 T8309 auxpass were,observed
R5691 T8326 T8309 prep at,observed
R5692 T8327 T8328 nummod 9,mo
R5693 T8328 T8326 pobj mo,at
R5694 T8329 T8327 cc and,9
R5695 T8330 T8327 conj 18,9
R5696 T8331 T8328 prep of,mo
R5697 T8332 T8331 pobj age,of
R5698 T8333 T8334 mark as,indicated
R5699 T8334 T8309 advcl indicated,observed
R570 T907 T908 amod Severe,cases
R5700 T8335 T8334 agent by,indicated
R5701 T8336 T8335 pobj asterisks,by
R5702 T8337 T8309 punct .,observed
R5703 T8339 T8340 compound Error,bars
R5704 T8340 T8341 nsubj bars,indicate
R5705 T8342 T8341 dobj SEM,indicate
R5706 T8343 T8341 punct .,indicate
R5707 T8564 T8565 compound TFIIH,Functions
R5708 T8566 T8565 cc and,Functions
R5709 T8567 T8565 conj Mechanisms,Functions
R571 T908 T909 nsubj cases,present
R5710 T8568 T8567 prep of,Mechanisms
R5711 T8569 T8570 npadvmod XPD,Associated
R5712 T8570 T8572 amod Associated,Pleiotropy
R5713 T8571 T8570 punct -,Associated
R5714 T8572 T8568 pobj Pleiotropy,of
R5715 T8573 T8572 compound Disease,Pleiotropy
R5716 T8575 T8576 punct (,A
R5717 T8576 T8577 meta A,survival
R5718 T8578 T8576 punct ),A
R5719 T8579 T8577 amod Cellular,survival
R572 T910 T909 aux can,present
R5720 T8580 T8577 prep after,survival
R5721 T8581 T8582 compound UV,irradiation
R5722 T8582 T8580 pobj irradiation,after
R5723 T8583 T8577 punct .,survival
R5724 T8585 T8586 nsubjpass Rescue,illustrated
R5725 T8587 T8585 prep of,Rescue
R5726 T8588 T8589 amod hemizygous,survival
R5727 T8589 T8587 pobj survival,of
R5728 T8590 T8591 compound XpdTTD,KO
R5729 T8591 T8589 compound KO,survival
R573 T911 T909 advmod also,present
R5730 T8592 T8591 punct /,KO
R5731 T8593 T8585 prep by,Rescue
R5732 T8594 T8595 nmod Xpd†XPCS,alleles
R5733 T8595 T8593 pobj alleles,by
R5734 T8596 T8594 cc and,Xpd†XPCS
R5735 T8597 T8594 conj Xpd†XP,Xpd†XPCS
R5736 T8598 T8586 auxpass is,illustrated
R5737 T8599 T8586 agent by,illustrated
R5738 T8600 T8599 pobj arrows,by
R5739 T8601 T8600 acl marked,arrows
R574 T912 T909 prep with,present
R5740 T8602 T8601 oprd A,marked
R5741 T8603 T8602 cc and,A
R5742 T8604 T8602 conj B,A
R5743 T8605 T8601 punct ", ",marked
R5744 T8606 T8601 advmod respectively,marked
R5745 T8607 T8586 punct .,illustrated
R5746 T8609 T8610 compound UV,survival
R5747 T8610 T8611 nsubjpass survival,depicted
R5748 T8612 T8610 prep of,survival
R5749 T8613 T8614 amod homozygous,cells
R575 T913 T914 compound growth,retardation
R5750 T8614 T8612 pobj cells,of
R5751 T8615 T8616 compound XpdXPCS,XPCS
R5752 T8616 T8614 compound XPCS,cells
R5753 T8617 T8616 punct /,XPCS
R5754 T8618 T8619 punct (,asterisk
R5755 T8619 T8614 parataxis asterisk,cells
R5756 T8620 T8619 punct ),asterisk
R5757 T8621 T8614 prep from,cells
R5758 T8622 T8623 det the,allele
R5759 T8623 T8621 pobj allele,from
R576 T914 T912 pobj retardation,with
R5760 T8624 T8625 advmod normally,expressed
R5761 T8625 T8623 amod expressed,allele
R5762 T8626 T8623 amod viable,allele
R5763 T8627 T8628 punct (,XpdXPCS
R5764 T8628 T8623 parataxis XpdXPCS,allele
R5765 T8629 T8628 punct ),XpdXPCS
R5766 T8630 T8611 auxpass is,depicted
R5767 T8631 T8611 prep by,depicted
R5768 T8632 T8633 det a,line
R5769 T8633 T8631 pobj line,by
R577 T915 T914 cc and,retardation
R5770 T8634 T8633 amod dotted,line
R5771 T8635 T8611 punct .,depicted
R5772 T8637 T8638 compound Survival,curves
R5773 T8638 T8639 nsubj curves,represent
R5774 T8639 T8640 ccomp represent,included
R5775 T8641 T8642 det an,average
R5776 T8642 T8639 dobj average,represent
R5777 T8643 T8642 prep of,average
R5778 T8644 T8645 nummod four,experiments
R5779 T8645 T8643 pobj experiments,of
R578 T916 T917 amod primary,neurodegeneration
R5780 T8646 T8645 amod independent,experiments
R5781 T8647 T8640 punct ;,included
R5782 T8648 T8649 quantmod 1,2
R5783 T8649 T8651 nummod 2,lines
R5784 T8650 T8649 punct –,2
R5785 T8651 T8640 nsubjpass lines,included
R5786 T8652 T8651 compound cell,lines
R5787 T8653 T8651 prep per,lines
R5788 T8654 T8653 pobj genotype,per
R5789 T8655 T8640 auxpass were,included
R579 T917 T914 conj neurodegeneration,retardation
R5790 T8656 T8640 prep in,included
R5791 T8657 T8658 det each,experiment
R5792 T8658 T8656 pobj experiment,in
R5793 T8659 T8640 punct .,included
R5794 T8661 T8662 compound Error,bars
R5795 T8662 T8663 nsubj bars,indicate
R5796 T8664 T8663 dobj SEM,indicate
R5797 T8665 T8664 prep between,SEM
R5798 T8666 T8665 pobj experiments,between
R5799 T8667 T8663 punct .,indicate
R580 T918 T919 punct [,11
R5800 T8669 T8670 punct (,B
R5801 T8670 T8671 meta B,UDS
R5802 T8672 T8670 punct ),B
R5803 T8673 T8671 compound UV,UDS
R5804 T8674 T8671 punct -,UDS
R5805 T8675 T8671 punct ", ",UDS
R5806 T8676 T8677 det a,measure
R5807 T8677 T8671 appos measure,UDS
R5808 T8678 T8677 prep of,measure
R5809 T8679 T8680 amod global,repair
R581 T919 T909 parataxis 11,present
R5810 T8680 T8678 pobj repair,of
R5811 T8681 T8680 compound genome,repair
R5812 T8682 T8671 punct .,UDS
R5813 T8684 T8685 dep Number,included
R5814 T8686 T8684 prep of,Number
R5815 T8687 T8686 pobj experiments,of
R5816 T8688 T8685 punct : ,included
R5817 T8689 T8690 nsubj n,15
R5818 T8690 T8685 ccomp 15,included
R5819 T8691 T8690 punct =,15
R582 T920 T919 punct ],11
R5820 T8692 T8693 punct (,XpdTTD
R5821 T8693 T8690 parataxis XpdTTD,15
R5822 T8694 T8693 punct /,XpdTTD
R5823 T8695 T8693 dep TTD,XpdTTD
R5824 T8696 T8693 punct ),XpdTTD
R5825 T8697 T8685 punct ", ",included
R5826 T8698 T8699 nsubj n,6
R5827 T8699 T8685 ccomp 6,included
R5828 T8700 T8699 punct =,6
R5829 T8701 T8702 punct (,KO
R583 T921 T909 punct .,present
R5830 T8702 T8699 parataxis KO,6
R5831 T8703 T8702 compound XpdTTD,KO
R5832 T8704 T8702 punct /,KO
R5833 T8705 T8702 punct ),KO
R5834 T8706 T8685 punct ", ",included
R5835 T8707 T8708 nsubj n,4
R5836 T8708 T8685 ccomp 4,included
R5837 T8709 T8708 punct =,4
R5838 T8710 T8711 punct (,†XPCS
R5839 T8711 T8708 parataxis †XPCS,4
R584 T923 T924 nsubj CS,are
R5840 T8712 T8711 compound XpdTTD,†XPCS
R5841 T8713 T8711 punct /,†XPCS
R5842 T8714 T8711 punct ),†XPCS
R5843 T8715 T8685 punct ", ",included
R5844 T8716 T8717 nsubj n,2
R5845 T8717 T8685 ccomp 2,included
R5846 T8718 T8717 punct =,2
R5847 T8719 T8720 punct (,†XP
R5848 T8720 T8717 parataxis †XP,2
R5849 T8721 T8720 compound XpdTTD,†XP
R585 T925 T923 cc and,CS
R5850 T8722 T8720 punct /,†XP
R5851 T8723 T8720 punct ),†XP
R5852 T8724 T8685 punct ;,included
R5853 T8725 T8726 quantmod 1,2
R5854 T8726 T8728 nummod 2,lines
R5855 T8727 T8726 punct –,2
R5856 T8728 T8685 nsubjpass lines,included
R5857 T8729 T8728 compound cell,lines
R5858 T8730 T8728 prep per,lines
R5859 T8731 T8730 pobj genotype,per
R586 T926 T923 conj TTD,CS
R5860 T8732 T8685 auxpass were,included
R5861 T8733 T8685 prep in,included
R5862 T8734 T8735 det each,experiment
R5863 T8735 T8733 pobj experiment,in
R5864 T8736 T8685 punct .,included
R5865 T8738 T8739 det The,asterisk
R5866 T8739 T8740 nsubj asterisk,indicates
R5867 T8740 T8741 ccomp indicates,indicate
R5868 T8742 T8743 amod significant,difference
R5869 T8743 T8740 dobj difference,indicates
R587 T927 T924 punct ", ",are
R5870 T8744 T8743 prep with,difference
R5871 T8745 T8746 compound XpdTTD,TTD
R5872 T8746 T8744 pobj TTD,with
R5873 T8747 T8746 punct /,TTD
R5874 T8748 T8741 punct ;,indicate
R5875 T8749 T8741 nsubj crosses,indicate
R5876 T8750 T8751 amod significant,differences
R5877 T8751 T8741 dobj differences,indicate
R5878 T8752 T8751 prep with,differences
R5879 T8753 T8754 compound XpdTTD,KO
R588 T928 T924 prep on,are
R5880 T8754 T8752 pobj KO,with
R5881 T8755 T8754 punct /,KO
R5882 T8756 T8741 punct .,indicate
R5883 T8758 T8759 punct (,C
R5884 T8759 T8760 meta C,RRS
R5885 T8761 T8759 punct ),C
R5886 T8762 T8760 compound UV,RRS
R5887 T8763 T8760 punct -,RRS
R5888 T8764 T8760 punct ", ",RRS
R5889 T8765 T8766 det a,measure
R589 T929 T930 det the,hand
R5890 T8766 T8760 appos measure,RRS
R5891 T8767 T8766 prep of,measure
R5892 T8768 T8769 npadvmod transcription,coupled
R5893 T8769 T8771 amod coupled,repair
R5894 T8770 T8769 punct -,coupled
R5895 T8771 T8767 pobj repair,of
R5896 T8772 T8771 prep of,repair
R5897 T8773 T8774 npadvmod UV,induced
R5898 T8774 T8776 amod induced,lesions
R5899 T8775 T8774 punct -,induced
R590 T930 T928 pobj hand,on
R5900 T8776 T8772 pobj lesions,of
R5901 T8777 T8760 punct .,RRS
R5902 T8779 T8780 dep Number,included
R5903 T8781 T8779 prep of,Number
R5904 T8782 T8781 pobj experiments,of
R5905 T8783 T8780 punct : ,included
R5906 T8784 T8785 nsubj n,7
R5907 T8785 T8780 ccomp 7,included
R5908 T8786 T8785 punct =,7
R5909 T8787 T8788 punct (,TTD
R591 T931 T930 amod other,hand
R5910 T8788 T8785 parataxis TTD,7
R5911 T8789 T8788 compound XpdTTD,TTD
R5912 T8790 T8788 punct /,TTD
R5913 T8791 T8788 punct ),TTD
R5914 T8792 T8780 punct ", ",included
R5915 T8793 T8794 nsubj n,2
R5916 T8794 T8780 ccomp 2,included
R5917 T8795 T8794 punct =,2
R5918 T8796 T8797 punct (,KO
R5919 T8797 T8794 parataxis KO,2
R592 T932 T924 punct ", ",are
R5920 T8798 T8797 compound XpdTTD,KO
R5921 T8799 T8797 punct /,KO
R5922 T8800 T8797 punct ),KO
R5923 T8801 T8780 punct ", ",included
R5924 T8802 T8803 nsubj n,4
R5925 T8803 T8780 ccomp 4,included
R5926 T8804 T8803 punct =,4
R5927 T8805 T8806 punct (,†XPCS
R5928 T8806 T8803 parataxis †XPCS,4
R5929 T8807 T8806 compound XpdTTD,†XPCS
R593 T933 T934 amod segmental,disorders
R5930 T8808 T8806 punct /,†XPCS
R5931 T8809 T8806 punct ),†XPCS
R5932 T8810 T8780 punct ", ",included
R5933 T8811 T8812 nsubj n,2
R5934 T8812 T8780 ccomp 2,included
R5935 T8813 T8812 punct =,2
R5936 T8814 T8815 punct (,†XP
R5937 T8815 T8812 parataxis †XP,2
R5938 T8816 T8815 compound XpdTTD,†XP
R5939 T8817 T8815 punct /,†XP
R594 T934 T924 attr disorders,are
R5940 T8818 T8815 punct ),†XP
R5941 T8819 T8780 punct ;,included
R5942 T8820 T8821 quantmod 1,2
R5943 T8821 T8823 nummod 2,lines
R5944 T8822 T8821 punct –,2
R5945 T8823 T8780 nsubjpass lines,included
R5946 T8824 T8823 compound cell,lines
R5947 T8825 T8823 prep per,lines
R5948 T8826 T8825 pobj genotype,per
R5949 T8827 T8780 auxpass were,included
R595 T935 T934 amod progeroid,disorders
R5950 T8828 T8780 prep in,included
R5951 T8829 T8830 det each,experiment
R5952 T8830 T8828 pobj experiment,in
R5953 T8831 T8780 punct .,included
R5954 T8833 T8834 punct (,D
R5955 T8834 T8835 meta D,activity
R5956 T8836 T8834 punct ),D
R5957 T8837 T8838 compound Incision,excision
R5958 T8838 T8835 compound excision,activity
R5959 T8839 T8838 punct /,excision
R596 T936 T934 acl characterised,disorders
R5960 T8840 T8835 prep of,activity
R5961 T8841 T8840 pobj combinations,of
R5962 T8842 T8841 prep of,combinations
R5963 T8843 T8844 amod altered,complexes
R5964 T8844 T8842 pobj complexes,of
R5965 T8845 T8844 compound TFIIH,complexes
R5966 T8846 T8844 prep in,complexes
R5967 T8847 T8848 det a,reaction
R5968 T8848 T8846 pobj reaction,in
R5969 T8849 T8848 amod reconstituted,reaction
R597 T937 T936 agent by,characterised
R5970 T8850 T8848 compound NER,reaction
R5971 T8851 T8835 punct .,activity
R5972 T8853 T8854 amod Equal,amounts
R5973 T8854 T8855 nsubjpass amounts,mixed
R5974 T8856 T8854 prep of,amounts
R5975 T8857 T8858 amod single,populations
R5976 T8858 T8856 pobj populations,of
R5977 T8859 T8857 cc or,single
R5978 T8860 T8857 conj mixed,single
R5979 T8861 T8858 prep of,populations
R598 T938 T939 amod progressive,failure
R5980 T8862 T8863 amod recombinant,TFIIHs
R5981 T8863 T8861 pobj TFIIHs,of
R5982 T8864 T8858 punct (,populations
R5983 T8865 T8858 acl containing,populations
R5984 T8866 T8865 dobj XPD,containing
R5985 T8867 T8866 punct ", ",XPD
R5986 T8868 T8866 conj XPB,XPD
R5987 T8869 T8868 punct ", ",XPB
R5988 T8870 T8868 conj p62,XPB
R5989 T8871 T8870 punct ", ",p62
R599 T939 T937 pobj failure,by
R5990 T8872 T8870 conj p52,p62
R5991 T8873 T8872 punct ", ",p52
R5992 T8874 T8875 compound His,p44
R5993 T8875 T8872 conj p44,p52
R5994 T8876 T8875 punct -,p44
R5995 T8877 T8875 punct ", ",p44
R5996 T8878 T8879 compound Flag,p34
R5997 T8879 T8875 conj p34,p44
R5998 T8880 T8879 punct -,p34
R5999 T8881 T8879 punct ", ",p34
R600 T940 T939 amod post-natal,failure
R6000 T8882 T8879 conj cdk7,p34
R6001 T8883 T8882 punct ", ",cdk7
R6002 T8884 T8885 compound cyclin,H
R6003 T8885 T8882 conj H,cdk7
R6004 T8886 T8885 punct ", ",H
R6005 T8887 T8885 conj Mat1,H
R6006 T8888 T8887 punct ", ",Mat1
R6007 T8889 T8887 cc and,Mat1
R6008 T8890 T8887 conj p8,Mat1
R6009 T8891 T8855 punct ),mixed
R601 T941 T939 compound growth,failure
R6010 T8892 T8855 auxpass were,mixed
R6011 T8893 T8855 prep with,mixed
R6012 T8894 T8895 amod recombinant,XPG
R6013 T8895 T8893 pobj XPG,with
R6014 T8896 T8895 punct ", ",XPG
R6015 T8897 T8898 compound XPF,ERCC1
R6016 T8898 T8895 appos ERCC1,XPG
R6017 T8899 T8898 punct /,ERCC1
R6018 T8900 T8895 punct ", ",XPG
R6019 T8901 T8902 compound XPC,hHR23B
R602 T942 T939 cc and,failure
R6020 T8902 T8895 appos hHR23B,XPG
R6021 T8903 T8902 punct /,hHR23B
R6022 T8904 T8895 punct ", ",XPG
R6023 T8905 T8895 appos RPA,XPG
R6024 T8906 T8895 punct ", ",XPG
R6025 T8907 T8895 cc and,XPG
R6026 T8908 T8909 det a,substrate
R6027 T8909 T8895 conj substrate,XPG
R6028 T8910 T8909 amod radiolabelled,substrate
R6029 T8911 T8909 amod synthetic,substrate
R603 T943 T944 amod primary,demyelination
R6030 T8912 T8909 compound NER,substrate
R6031 T8913 T8855 punct .,mixed
R6032 T8915 T8916 det The,products
R6033 T8916 T8918 nsubjpass products,visualised
R6034 T8917 T8916 compound excision,products
R6035 T8919 T8920 punct (,nucleotides
R6036 T8920 T8916 parataxis nucleotides,products
R6037 T8921 T8922 quantmod 26,34
R6038 T8922 T8920 nummod 34,nucleotides
R6039 T8923 T8922 punct –,34
R604 T944 T939 conj demyelination,failure
R6040 T8924 T8920 prep in,nucleotides
R6041 T8925 T8924 pobj length,in
R6042 T8926 T8920 punct ),nucleotides
R6043 T8927 T8918 auxpass were,visualised
R6044 T8928 T8918 prep at,visualised
R6045 T8929 T8930 compound nucleotide,resolution
R6046 T8930 T8928 pobj resolution,at
R6047 T8931 T8918 prep on,visualised
R6048 T8932 T8933 det a,gel
R6049 T8933 T8931 pobj gel,on
R605 T945 T944 acl resulting,demyelination
R6050 T8934 T8933 amod denaturing,gel
R6051 T8935 T8933 compound polyacrylamide,gel
R6052 T8936 T8937 mark as,indicated
R6053 T8937 T8918 advcl indicated,visualised
R6054 T8938 T8918 punct .,visualised
R6055 T8941 T8942 det the,activity
R6056 T8942 T8940 dobj activity,Note
R6057 T8943 T8942 amod weak,activity
R6058 T8944 T8942 acl corresponding,activity
R6059 T8945 T8944 prep to,corresponding
R606 T946 T945 prep in,resulting
R6060 T8946 T8947 det each,complex
R6061 T8947 T8945 pobj complex,to
R6062 T8948 T8947 amod single,complex
R6063 T8949 T8948 cc and,single
R6064 T8950 T8948 conj combined,single
R6065 T8951 T8947 compound TFIIH,complex
R6066 T8952 T8953 punct (,3
R6067 T8953 T8947 parataxis 3,complex
R6068 T8954 T8953 nmod lanes,3
R6069 T8955 T8956 punct –,8
R607 T947 T948 amod severe,neurodysfunction
R6070 T8956 T8953 prep 8,3
R6071 T8957 T8953 punct ),3
R6072 T8958 T8944 advcl relative,corresponding
R6073 T8959 T8958 prep to,relative
R6074 T8960 T8961 det the,wt
R6075 T8961 T8959 pobj wt,to
R6076 T8962 T8963 punct (,lane
R6077 T8963 T8961 parataxis lane,wt
R6078 T8964 T8963 nummod 1,lane
R6079 T8965 T8963 punct ),lane
R608 T948 T946 pobj neurodysfunction,in
R6080 T8966 T8961 cc and,wt
R6081 T8967 T8968 amod negative,controls
R6082 T8968 T8961 conj controls,wt
R6083 T8969 T8970 punct (,lane
R6084 T8970 T8968 parataxis lane,controls
R6085 T8971 T8970 nummod 2,lane
R6086 T8972 T8970 punct ),lane
R6087 T8973 T8940 punct .,Note
R6088 T8975 T8976 punct (,E
R6089 T8976 T8977 meta E,reduction
R609 T949 T924 punct ", ",are
R6090 T8978 T8976 punct ),E
R6091 T8979 T8977 nmod Xpd,reduction
R6092 T8980 T8981 npadvmod dose,dependent
R6093 T8981 T8977 amod dependent,reduction
R6094 T8982 T8981 punct -,dependent
R6095 T8983 T8977 prep of,reduction
R6096 T8984 T8983 pobj TFIIH,of
R6097 T8985 T8977 prep in,reduction
R6098 T8986 T8987 amod homozygous,TTD
R6099 T8987 T8990 nmod TTD,cells
R610 T950 T951 cc but,without
R6100 T8988 T8987 nmod XpdTTD,TTD
R6101 T8989 T8987 punct /,TTD
R6102 T8990 T8985 pobj cells,in
R6103 T8991 T8987 punct ", ",TTD
R6104 T8992 T8993 amod hemizygous,KO
R6105 T8993 T8987 conj KO,TTD
R6106 T8994 T8993 compound XpdTTD,KO
R6107 T8995 T8993 punct /,KO
R6108 T8996 T8993 punct ", ",KO
R6109 T8997 T8993 cc and,KO
R611 T951 T924 prep without,are
R6110 T8998 T8999 nmod compound,†XPCS
R6111 T8999 T8993 conj †XPCS,KO
R6112 T9000 T8999 amod heterozygous,†XPCS
R6113 T9001 T8999 compound XpdTTD,†XPCS
R6114 T9002 T8999 punct /,†XPCS
R6115 T9003 T8999 cc and,†XPCS
R6116 T9004 T9005 compound XpdTTD,†XP
R6117 T9005 T8999 conj †XP,†XPCS
R6118 T9006 T9005 punct /,†XP
R6119 T9007 T8977 prep by,reduction
R612 T952 T953 det a,predisposition
R6120 T9008 T9009 amod comparative,immunofluorescence
R6121 T9009 T9007 pobj immunofluorescence,by
R6122 T9010 T9009 prep of,immunofluorescence
R6123 T9011 T9012 det the,subunit
R6124 T9012 T9010 pobj subunit,of
R6125 T9013 T9012 compound p62,subunit
R6126 T9014 T9012 prep of,subunit
R6127 T9015 T9014 pobj TFIIH,of
R6128 T9016 T8977 punct .,reduction
R6129 T9018 T9019 amod Roman,numerals
R613 T953 T951 pobj predisposition,without
R6130 T9019 T9020 nsubj numerals,represent
R6131 T9021 T9022 amod different,slides
R6132 T9022 T9020 dobj slides,represent
R6133 T9023 T9022 amod microscopic,slides
R6134 T9024 T9020 cc and,represent
R6135 T9025 T9026 amod Arabic,numerals
R6136 T9026 T9027 nsubj numerals,lines
R6137 T9027 T9020 conj lines,represent
R6138 T9028 T9027 amod different,lines
R6139 T9029 T9027 compound cell,lines
R614 T954 T953 amod clear,predisposition
R6140 T9030 T9027 acl labelled,lines
R6141 T9031 T9032 mark as,follows
R6142 T9032 T9030 advcl follows,labelled
R6143 T9033 T9027 punct : ,lines
R6144 T9034 T9035 punct (,I
R6145 T9035 T9036 meta I,cells
R6146 T9036 T9027 dep cells,lines
R6147 T9037 T9035 punct ),I
R6148 T9038 T9036 compound wt,cells
R6149 T9039 T9040 punct (,1
R615 T955 T953 compound cancer,predisposition
R6150 T9040 T9036 parataxis 1,cells
R6151 T9041 T9040 punct ),1
R6152 T9042 T9036 acl labelled,cells
R6153 T9043 T9042 prep with,labelled
R6154 T9044 T9045 nummod 2,μm
R6155 T9045 T9047 compound μm,beads
R6156 T9046 T9045 punct -,μm
R6157 T9047 T9043 pobj beads,with
R6158 T9048 T9036 punct ", ",cells
R6159 T9049 T9050 compound XpdTTD,TTD
R616 T956 T957 punct [,12
R6160 T9050 T9052 compound TTD,cells
R6161 T9051 T9050 punct /,TTD
R6162 T9052 T9036 conj cells,cells
R6163 T9053 T9054 punct (,2
R6164 T9054 T9052 parataxis 2,cells
R6165 T9055 T9054 punct ),2
R6166 T9056 T9052 prep with,cells
R6167 T9057 T9058 nummod 0.79,μm
R6168 T9058 T9060 compound μm,beads
R6169 T9059 T9058 punct -,μm
R617 T957 T924 parataxis 12,are
R6170 T9060 T9056 pobj beads,with
R6171 T9061 T9052 punct ", ",cells
R6172 T9062 T9052 cc and,cells
R6173 T9063 T9064 compound XpdTTD,KO
R6174 T9064 T9066 compound KO,cells
R6175 T9065 T9064 punct /,KO
R6176 T9066 T9052 conj cells,cells
R6177 T9067 T9068 punct (,3
R6178 T9068 T9066 parataxis 3,cells
R6179 T9069 T9068 punct ),3
R618 T958 T959 punct –,15
R6180 T9070 T9066 prep with,cells
R6181 T9071 T9072 det no,beads
R6182 T9072 T9070 pobj beads,with
R6183 T9073 T9036 punct ;,cells
R6184 T9074 T9075 punct (,II
R6185 T9075 T9076 meta II,cells
R6186 T9076 T9036 conj cells,cells
R6187 T9077 T9075 punct ),II
R6188 T9078 T9076 compound wt,cells
R6189 T9079 T9080 punct (,1
R619 T959 T957 prep 15,12
R6190 T9080 T9076 parataxis 1,cells
R6191 T9081 T9080 punct ),1
R6192 T9082 T9076 acl labelled,cells
R6193 T9083 T9082 prep with,labelled
R6194 T9084 T9085 nummod 0.79,μm
R6195 T9085 T9087 compound μm,beads
R6196 T9086 T9085 punct -,μm
R6197 T9087 T9083 pobj beads,with
R6198 T9088 T9076 cc and,cells
R6199 T9089 T9090 compound XpdTTD,†XPCS
R620 T960 T957 punct ],12
R6200 T9090 T9092 compound †XPCS,cells
R6201 T9091 T9090 punct /,†XPCS
R6202 T9092 T9076 conj cells,cells
R6203 T9093 T9094 punct (,4
R6204 T9094 T9092 parataxis 4,cells
R6205 T9095 T9094 punct ),4
R6206 T9096 T9092 prep with,cells
R6207 T9097 T9098 det no,beads
R6208 T9098 T9096 pobj beads,with
R6209 T9099 T9076 punct ;,cells
R621 T961 T924 punct .,are
R6210 T9100 T9076 cc and,cells
R6211 T9101 T9102 punct (,III
R6212 T9102 T9103 meta III,cells
R6213 T9103 T9076 conj cells,cells
R6214 T9104 T9102 punct ),III
R6215 T9105 T9103 compound wt,cells
R6216 T9106 T9107 punct (,1
R6217 T9107 T9103 parataxis 1,cells
R6218 T9108 T9107 punct ),1
R6219 T9109 T9103 acl labelled,cells
R622 T963 T964 nsubj Patients,display
R6220 T9110 T9109 prep with,labelled
R6221 T9111 T9112 nummod 0.79,μm
R6222 T9112 T9114 compound μm,beads
R6223 T9113 T9112 punct -,μm
R6224 T9114 T9110 pobj beads,with
R6225 T9115 T9103 cc and,cells
R6226 T9116 T9117 compound XpdTTD,†XP
R6227 T9117 T9119 compound †XP,cells
R6228 T9118 T9117 punct /,†XP
R6229 T9119 T9103 conj cells,cells
R623 T965 T963 prep with,Patients
R6230 T9120 T9121 punct (,5
R6231 T9121 T9119 parataxis 5,cells
R6232 T9122 T9121 punct ),5
R6233 T9123 T9119 prep with,cells
R6234 T9124 T9125 det no,beads
R6235 T9125 T9123 pobj beads,with
R6236 T9126 T9027 punct .,lines
R6237 T9128 T9129 punct (,F
R6238 T9129 T9130 meta F,Quantification
R6239 T9131 T9129 punct ),F
R624 T966 T965 pobj TTD,with
R6240 T9132 T9130 prep of,Quantification
R6241 T9133 T9134 amod immunofluorescent,signal
R6242 T9134 T9132 pobj signal,of
R6243 T9135 T9134 prep from,signal
R6244 T9136 T9137 advmod at,50
R6245 T9137 T9139 nummod 50,nuclei
R6246 T9138 T9137 advmod least,50
R6247 T9139 T9135 pobj nuclei,from
R6248 T9140 T9139 prep per,nuclei
R6249 T9141 T9142 compound cell,line
R625 T967 T964 advmod additionally,display
R6250 T9142 T9140 pobj line,per
R6251 T9143 T9139 cc and,nuclei
R6252 T9144 T9145 quantmod 2,6
R6253 T9145 T9147 nummod 6,experiments
R6254 T9146 T9145 punct –,6
R6255 T9147 T9139 conj experiments,nuclei
R6256 T9148 T9147 prep per,experiments
R6257 T9149 T9148 pobj genotype,per
R6258 T9150 T9130 punct .,Quantification
R6259 T9152 T9153 nsubjpass Bars,depicted
R626 T968 T969 nmod hallmark,hair
R6260 T9154 T9152 acl representing,Bars
R6261 T9155 T9154 dobj cells,representing
R6262 T9156 T9155 acl analysed,cells
R6263 T9157 T9156 prep on,analysed
R6264 T9158 T9159 det the,slide
R6265 T9159 T9157 pobj slide,on
R6266 T9160 T9159 amod same,slide
R6267 T9161 T9159 amod microscopic,slide
R6268 T9162 T9153 auxpass are,depicted
R6269 T9163 T9153 npadvmod side,depicted
R627 T969 T964 dobj hair,display
R6270 T9164 T9163 prep by,side
R6271 T9165 T9164 pobj side,by
R6272 T9166 T9153 punct ", ",depicted
R6273 T9167 T9153 prep with,depicted
R6274 T9168 T9167 pobj wt,with
R6275 T9169 T9168 acl set,wt
R6276 T9170 T9169 prep at,set
R6277 T9171 T9172 nummod 100,%
R6278 T9172 T9170 pobj %,at
R6279 T9173 T9153 punct .,depicted
R628 T970 T971 npadvmod sulphur,deficient
R6280 T9175 T9176 det The,value
R6281 T9176 T9179 nsubj value,indicates
R6282 T9177 T9176 compound p,value
R6283 T9178 T9176 punct -,value
R6284 T9180 T9181 amod minimum,difference
R6285 T9181 T9179 dobj difference,indicates
R6286 T9182 T9181 amod significant,difference
R6287 T9183 T9181 prep between,difference
R6288 T9184 T9183 pobj wt,between
R6289 T9185 T9184 cc and,wt
R629 T971 T969 amod deficient,hair
R6290 T9186 T9187 det the,lines
R6291 T9187 T9184 conj lines,wt
R6292 T9188 T9187 amod indicated,lines
R6293 T9189 T9187 compound cell,lines
R6294 T9190 T9187 acl analysed,lines
R6295 T9191 T9190 prep on,analysed
R6296 T9192 T9193 det the,slide
R6297 T9193 T9191 pobj slide,on
R6298 T9194 T9193 amod same,slide
R6299 T9195 T9193 amod microscopic,slide
R630 T972 T971 punct -,deficient
R6300 T9196 T9181 prep within,difference
R6301 T9197 T9198 nummod one,experiment
R6302 T9198 T9196 pobj experiment,within
R6303 T9199 T9179 punct .,indicates
R6304 T9212 T9211 prep of,Frequency
R6305 T9213 T9214 compound Xpd†XP,†XP
R6306 T9214 T9212 pobj †XP,of
R6307 T9215 T9214 punct /,†XP
R6308 T9216 T9214 punct ", ",†XP
R6309 T9217 T9218 compound Xpd†XPCS,†XPCS
R631 T973 T969 amod brittle,hair
R6310 T9218 T9214 conj †XPCS,†XP
R6311 T9219 T9218 punct /,†XPCS
R6312 T9220 T9218 punct ", ",†XPCS
R6313 T9221 T9218 cc and,†XPCS
R6314 T9222 T9223 nmod Compound,†XPCS
R6315 T9223 T9218 conj †XPCS,†XPCS
R6316 T9224 T9223 amod Heterozygous,†XPCS
R6317 T9225 T9223 compound Xpd†XP,†XPCS
R6318 T9226 T9223 punct /,†XPCS
R6319 T9227 T9214 appos Embryos,†XP
R632 T974 T969 cc and,hair
R6320 T9228 T9227 cc and,Embryos
R6321 T9229 T9227 conj Offspring,Embryos
R6322 T9241 T9242 amod Pleiotropic,Effects
R6323 T9243 T9242 nmod Xpd,Effects
R6324 T9244 T9242 amod Biallelic,Effects
R6325 T9245 T9242 prep in,Effects
R6326 T9246 T9245 pobj Mice,in
R6327 T9247 T9246 cc and,Mice
R6328 T9248 T9246 conj Cells,Mice
R6329 T9280 T9281 compound Genotype,Phenotype
R633 T975 T969 conj nails,hair
R6330 T9281 T9283 compound Phenotype,Relationships
R6331 T9282 T9281 punct –,Phenotype
R6332 T9284 T9283 prep in,Relationships
R6333 T9285 T9286 compound XPD,Disorders
R6334 T9286 T9284 pobj Disorders,in
R6335 T9288 T9289 prep According,determined
R6336 T9290 T9288 prep to,According
R6337 T9291 T9292 det the,hypothesis
R6338 T9292 T9290 pobj hypothesis,to
R6339 T9293 T9292 amod current,hypothesis
R634 T976 T969 cc and,hair
R6340 T9294 T9292 amod monoallelic,hypothesis
R6341 T9295 T9289 punct ", ",determined
R6342 T9296 T9289 nsubjpass phenotype,determined
R6343 T9297 T9289 auxpass is,determined
R6344 T9298 T9299 advmod solely,by
R6345 T9299 T9289 agent by,determined
R6346 T9300 T9301 det the,product
R6347 T9301 T9299 pobj product,by
R6348 T9302 T9301 amod causative,product
R6349 T9303 T9301 compound allele,product
R635 T977 T978 amod scaling,skin
R6350 T9304 T9289 punct .,determined
R6351 T9306 T9307 mark If,is
R6352 T9307 T9313 advcl is,considered
R6353 T9308 T9309 det a,allele
R6354 T9309 T9307 nsubj allele,is
R6355 T9310 T9309 amod second,allele
R6356 T9311 T9309 punct ", ",allele
R6357 T9312 T9309 amod different,allele
R6358 T9314 T9307 acomp present,is
R6359 T9315 T9313 punct ", ",considered
R636 T978 T969 conj skin,hair
R6360 T9316 T9313 nsubjpass it,considered
R6361 T9317 T9313 auxpass is,considered
R6362 T9318 T9319 det a,null
R6363 T9319 T9313 oprd null,considered
R6364 T9320 T9319 amod functional,null
R6365 T9321 T9313 punct .,considered
R6366 T9323 T9324 expl There,is
R6367 T9325 T9326 det a,lack
R6368 T9326 T9324 attr lack,is
R6369 T9327 T9326 prep of,lack
R637 T979 T980 punct [,13
R6370 T9328 T9329 det any,correlation
R6371 T9329 T9327 pobj correlation,of
R6372 T9330 T9329 prep between,correlation
R6373 T9331 T9332 det the,site
R6374 T9332 T9330 pobj site,between
R6375 T9333 T9332 prep of,site
R6376 T9334 T9335 det the,mutation
R6377 T9335 T9333 pobj mutation,of
R6378 T9336 T9335 compound XPD,mutation
R6379 T9337 T9332 cc and,site
R638 T980 T969 parataxis 13,hair
R6380 T9338 T9339 det the,disorder
R6381 T9339 T9332 conj disorder,site
R6382 T9340 T9339 amod resulting,disorder
R6383 T9341 T9324 punct .,is
R6384 T9343 T9344 nsubj We,propose
R6385 T9345 T9346 det a,hypothesis
R6386 T9346 T9344 dobj hypothesis,propose
R6387 T9347 T9346 amod biallelic,hypothesis
R6388 T9348 T9346 prep for,hypothesis
R6389 T9349 T9350 compound compound,heterozygotes
R639 T981 T980 punct ],13
R6390 T9350 T9348 pobj heterozygotes,for
R6391 T9351 T9352 prep in,contribute
R6392 T9352 T9346 relcl contribute,hypothesis
R6393 T9353 T9351 pobj which,in
R6394 T9354 T9355 det both,alleles
R6395 T9355 T9352 nsubj alleles,contribute
R6396 T9356 T9352 aux can,contribute
R6397 T9357 T9352 prep to,contribute
R6398 T9358 T9359 det the,phenotype
R6399 T9359 T9357 pobj phenotype,to
R640 T982 T969 punct ", ",hair
R6400 T9360 T9344 punct .,propose
R6401 T9362 T9363 nsubjpass Examples,provided
R6402 T9364 T9362 prep of,Examples
R6403 T9365 T9366 nmod compound,patients
R6404 T9366 T9364 pobj patients,of
R6405 T9367 T9366 amod heterozygous,patients
R6406 T9368 T9369 prep in,is
R6407 T9369 T9366 relcl is,patients
R6408 T9370 T9368 pobj which,in
R6409 T9371 T9372 det a,allele
R641 T983 T969 acl resulting,hair
R6410 T9372 T9369 nsubj allele,is
R6411 T9373 T9372 amod second,allele
R6412 T9374 T9372 punct ", ",allele
R6413 T9375 T9376 amod presumed,null
R6414 T9376 T9372 amod null,allele
R6415 T9377 T9369 acomp likely,is
R6416 T9378 T9379 aux to,contribute
R6417 T9379 T9377 xcomp contribute,likely
R6418 T9380 T9379 prep to,contribute
R6419 T9381 T9382 compound disease,outcome
R642 T984 T983 prep from,resulting
R6420 T9382 T9380 pobj outcome,to
R6421 T9383 T9363 auxpass are,provided
R6422 T9384 T9363 advmod above,provided
R6423 T9385 T9363 prep in,provided
R6424 T9386 T9385 pobj comparison,in
R6425 T9387 T9386 prep to,comparison
R6426 T9388 T9389 amod corresponding,patients
R6427 T9389 T9387 pobj patients,to
R6428 T9390 T9391 advmod homo,hemizygous
R6429 T9391 T9389 amod hemizygous,patients
R643 T985 T986 det a,defect
R6430 T9392 T9391 punct -,hemizygous
R6431 T9393 T9391 cc or,hemizygous
R6432 T9394 T9389 prep with,patients
R6433 T9395 T9396 det the,allele
R6434 T9396 T9394 pobj allele,with
R6435 T9397 T9396 amod same,allele
R6436 T9398 T9396 amod causative,allele
R6437 T9399 T9363 punct .,provided
R6438 T9401 T9402 nsubj Numbers,indicate
R6439 T9403 T9401 prep in,Numbers
R644 T986 T984 pobj defect,from
R6440 T9404 T9405 det the,schematic
R6441 T9405 T9403 pobj schematic,in
R6442 T9406 T9405 prep of,schematic
R6443 T9407 T9408 det the,protein
R6444 T9408 T9406 pobj protein,of
R6445 T9409 T9410 det the,domains
R6446 T9410 T9402 dobj domains,indicate
R6447 T9411 T9410 compound helicase,domains
R6448 T9412 T9402 punct .,indicate
R645 T987 T986 amod basal,defect
R646 T988 T986 compound transcription,defect
R647 T989 T986 prep in,defect
R648 T990 T991 amod specific,types
R649 T991 T989 pobj types,in
R650 T992 T991 compound cell,types
R651 T993 T994 punct [,17
R652 T994 T964 parataxis 17,display
R653 T995 T994 nummod 16,17
R654 T996 T994 punct ",",17
R655 T997 T994 punct ],17
R656 T998 T964 punct .,display
R657 T1000 T1001 det A,disorder
R658 T1001 T1003 nsubjpass disorder,described
R659 T1002 T1001 amod related,disorder
R660 T1004 T1001 prep with,disorder
R661 T1005 T1006 det the,predisposition
R662 T1006 T1004 pobj predisposition,with
R663 T1007 T1006 compound cancer,predisposition
R664 T1008 T1006 prep of,predisposition
R665 T1009 T1008 pobj XP,of
R666 T1010 T1006 acl combined,predisposition
R667 T1011 T1010 prep with,combined
R668 T1012 T1013 det the,complications
R669 T1013 T1011 pobj complications,with
R670 T1014 T1013 amod neurodevelopmental,complications
R671 T1015 T1013 prep of,complications
R672 T1016 T1015 pobj CS,of
R673 T1017 T1018 punct (,XPCS
R674 T1018 T1016 parataxis XPCS,CS
R675 T1019 T1018 punct ),XPCS
R676 T1020 T1003 punct ", ",described
R677 T1021 T1022 mark although,rare
R678 T1022 T1003 advcl rare,described
R679 T1023 T1003 punct ", ",described
R680 T1024 T1003 aux has,described
R681 T1025 T1003 advmod also,described
R682 T1026 T1003 auxpass been,described
R683 T1027 T1028 punct [,18
R684 T1028 T1003 parataxis 18,described
R685 T1029 T1028 punct ],18
R686 T1030 T1003 punct .,described
R687 T1032 T1033 amod Many,mutations
R688 T1033 T1035 nsubjpass mutations,associated
R689 T1034 T1033 compound XPD,mutations
R690 T1036 T1035 auxpass are,associated
R691 T1037 T1035 prep with,associated
R692 T1038 T1039 det an,phenotype
R693 T1039 T1037 pobj phenotype,with
R694 T1040 T1039 amod exclusive,phenotype
R695 T1041 T1039 compound disease,phenotype
R696 T1042 T1043 punct (,XPDR722W
R697 T1043 T1039 parataxis XPDR722W,phenotype
R698 T1044 T1043 advmod e.g.,XPDR722W
R699 T1045 T1043 punct ", ",XPDR722W
R700 T1046 T1043 prep with,XPDR722W
R701 T1047 T1046 pobj TTD,with
R702 T1048 T1043 cc and,XPDR722W
R703 T1049 T1043 conj XPDR683W,XPDR722W
R704 T1050 T1049 prep with,XPDR683W
R705 T1051 T1050 pobj XP,with
R706 T1052 T1043 punct ),XPDR722W
R707 T1053 T1035 cc and,associated
R708 T1054 T1055 auxpass are,viewed
R709 T1055 T1035 conj viewed,associated
R710 T1056 T1055 advmod thus,viewed
R711 T1057 T1055 prep as,viewed
R712 T1058 T1057 pobj causative,as
R713 T1059 T1058 prep of,causative
R714 T1060 T1061 det the,syndromes
R715 T1061 T1059 pobj syndromes,of
R716 T1062 T1061 amod corresponding,syndromes
R717 T1063 T1035 punct .,associated
R718 T1065 T1066 nsubjpass Alleles,considered
R719 T1067 T1068 neg not,associated
R720 T1068 T1065 acl associated,Alleles
R721 T1069 T1068 advmod exclusively,associated
R722 T1070 T1068 prep with,associated
R723 T1071 T1072 nummod one,disorder
R724 T1072 T1070 pobj disorder,with
R725 T1073 T1066 auxpass are,considered
R726 T1074 T1075 punct “,alleles
R727 T1075 T1066 oprd alleles,considered
R728 T1076 T1077 advmod likely,null
R729 T1077 T1075 amod null,alleles
R730 T1078 T1075 punct ”,alleles
R731 T1079 T1080 punct [,20
R732 T1080 T1066 parataxis 20,considered
R733 T1081 T1080 nummod 19,20
R734 T1082 T1080 punct ",",20
R735 T1083 T1080 punct ],20
R736 T1084 T1066 punct .,considered
R737 T1086 T1087 nsubj Some,fail
R738 T1088 T1086 prep of,Some
R739 T1089 T1090 det these,alleles
R740 T1090 T1088 pobj alleles,of
R741 T1091 T1092 aux to,support
R742 T1092 T1087 xcomp support,fail
R743 T1093 T1092 dobj viability,support
R744 T1094 T1092 prep in,support
R745 T1095 T1096 det a,strain
R746 T1096 T1094 pobj strain,in
R747 T1097 T1096 amod haploid,strain
R748 T1098 T1096 compound Schizosaccharomyces,strain
R749 T1099 T1096 compound pombe,strain
R750 T1100 T1096 compound yeast,strain
R751 T1101 T1096 prep with,strain
R752 T1102 T1103 det a,mutation
R753 T1103 T1101 pobj mutation,with
R754 T1104 T1103 amod null,mutation
R755 T1105 T1103 prep in,mutation
R756 T1106 T1107 det the,rad15
R757 T1107 T1105 pobj rad15,in
R758 T1108 T1107 compound XPD,rad15
R759 T1109 T1107 compound homologue,rad15
R760 T1110 T1087 cc and,fail
R761 T1111 T1112 auxpass are,considered
R762 T1112 T1087 conj considered,fail
R763 T1113 T1112 advmod thus,considered
R764 T1114 T1112 oprd devoid,considered
R765 T1115 T1114 prep of,devoid
R766 T1116 T1117 amod significant,activity
R767 T1117 T1115 pobj activity,of
R768 T1118 T1117 amod biological,activity
R769 T1119 T1120 punct [,19
R770 T1120 T1112 parataxis 19,considered
R771 T1121 T1120 punct ],19
R772 T1122 T1087 punct .,fail
R773 T1124 T1125 det This,classification
R774 T1125 T1126 nsubj classification,defines
R775 T1127 T1125 prep of,classification
R776 T1128 T1127 pobj alleles,of
R777 T1129 T1125 prep as,classification
R778 T1130 T1131 preconj either,causative
R779 T1131 T1129 amod causative,as
R780 T1132 T1131 cc or,causative
R781 T1133 T1131 conj null,causative
R782 T1134 T1126 advmod currently,defines
R783 T1135 T1136 dep what,refer
R784 T1136 T1126 ccomp refer,defines
R785 T1137 T1136 nsubj we,refer
R786 T1138 T1136 prep to,refer
R787 T1139 T1136 prep as,refer
R788 T1140 T1141 det a,paradigm
R789 T1141 T1139 pobj paradigm,as
R790 T1142 T1141 punct “,paradigm
R791 T1143 T1141 amod monoallelic,paradigm
R792 T1144 T1141 punct ”,paradigm
R793 T1145 T1141 prep of,paradigm
R794 T1146 T1147 compound XPD,disease
R795 T1147 T1145 pobj disease,of
R796 T1148 T1126 punct .,defines
R797 T1150 T1151 advmod However,casts
R798 T1152 T1151 punct ", ",casts
R799 T1153 T1154 det the,identification
R800 T1154 T1151 nsubj identification,casts
R801 T1155 T1154 prep in,identification
R802 T1156 T1157 amod recent,years
R803 T1157 T1155 pobj years,in
R804 T1158 T1157 prep of,years
R805 T1159 T1160 compound XP,patients
R806 T1160 T1158 pobj patients,of
R807 T1161 T1160 compound complementation,patients
R808 T1162 T1163 compound group,D
R809 T1163 T1160 compound D,patients
R810 T1164 T1160 prep with,patients
R811 T1165 T1166 amod atypical,presentation
R812 T1166 T1164 pobj presentation,with
R813 T1167 T1166 compound disease,presentation
R814 T1168 T1166 punct ", ",presentation
R815 T1169 T1166 prep including,presentation
R816 T1170 T1169 pobj symptoms,including
R817 T1171 T1170 prep of,symptoms
R818 T1172 T1173 preconj both,XP
R819 T1173 T1171 pobj XP,of
R820 T1174 T1173 cc and,XP
R821 T1175 T1173 conj TTD,XP
R822 T1176 T1177 punct [,8
R823 T1177 T1154 parataxis 8,identification
R824 T1178 T1177 punct ],8
R825 T1179 T1151 punct ", ",casts
R826 T1180 T1151 dobj doubt,casts
R827 T1181 T1151 prep on,casts
R828 T1182 T1183 det the,ability
R829 T1183 T1181 pobj ability,on
R830 T1184 T1183 prep of,ability
R831 T1185 T1186 amod such,paradigm
R832 T1186 T1184 pobj paradigm,of
R833 T1187 T1186 det a,paradigm
R834 T1188 T1186 amod monoallelic,paradigm
R835 T1189 T1190 aux to,explain
R836 T1190 T1183 acl explain,ability
R837 T1191 T1192 amod clinical,heterogeneity
R838 T1192 T1190 dobj heterogeneity,explain
R839 T1193 T1190 prep in,explain
R840 T1194 T1195 compound compound,heterozygotes
R841 T1195 T1193 pobj heterozygotes,in
R842 T1196 T1151 punct .,casts
R843 T1198 T1199 advmod Previously,generated
R844 T1200 T1199 punct ", ",generated
R845 T1201 T1199 nsubj we,generated
R846 T1202 T1203 det a,model
R847 T1203 T1199 dobj model,generated
R848 T1204 T1203 compound TTD,model
R849 T1205 T1203 compound mouse,model
R850 T1206 T1207 punct (,XPDR722W
R851 T1207 T1203 parataxis XPDR722W,model
R852 T1208 T1207 punct ),XPDR722W
R853 T1209 T1210 dep that,phenocopies
R854 T1210 T1203 relcl phenocopies,model
R855 T1211 T1212 det the,syndrome
R856 T1212 T1210 dobj syndrome,phenocopies
R857 T1213 T1212 amod human,syndrome
R858 T1214 T1215 punct [,21
R859 T1215 T1199 parataxis 21,generated
R860 T1216 T1215 nummod 15,21
R861 T1217 T1215 punct ",",21
R862 T1218 T1215 punct ],21
R863 T1219 T1199 punct .,generated
R864 T1221 T1222 advmod Here,report
R865 T1223 T1222 nsubj we,report
R866 T1224 T1225 det the,generation
R867 T1225 T1222 dobj generation,report
R868 T1226 T1225 prep of,generation
R869 T1227 T1228 amod additional,alleles
R870 T1228 T1226 pobj alleles,of
R871 T1229 T1228 amod mutant,alleles
R872 T1230 T1228 compound Xpd,alleles
R873 T1231 T1232 dep that,fail
R874 T1232 T1228 relcl fail,alleles
R875 T1233 T1234 aux to,support
R876 T1234 T1232 xcomp support,fail
R877 T1235 T1234 dobj viability,support
R878 T1236 T1234 prep on,support
R879 T1237 T1238 poss their,own
R880 T1238 T1236 pobj own,on
R881 T1239 T1232 cc but,fail
R882 T1240 T1241 advmod nevertheless,ameliorate
R883 T1241 T1232 conj ameliorate,fail
R884 T1242 T1243 npadvmod TTD,associated
R885 T1243 T1245 amod associated,ageing
R886 T1244 T1243 punct -,associated
R887 T1245 T1241 dobj ageing,ameliorate
R888 T1246 T1245 amod premature,ageing
R889 T1247 T1245 amod segmental,ageing
R890 T1248 T1245 punct ", ",ageing
R891 T1249 T1250 amod cutaneous,features
R892 T1250 T1245 conj features,ageing
R893 T1251 T1250 punct ", ",features
R894 T1252 T1253 amod cellular,capacity
R895 T1253 T1250 conj capacity,features
R896 T1254 T1255 compound DNA,repair
R897 T1255 T1253 compound repair,capacity
R898 T1256 T1253 punct ", ",capacity
R899 T1257 T1253 cc and,capacity
R900 T1258 T1259 compound UV,survival
R901 T1259 T1253 conj survival,capacity
R902 T1260 T1261 advmod when,present
R903 T1261 T1241 advcl present,ameliorate
R904 T1262 T1261 prep in,present
R905 T1263 T1264 det a,state
R906 T1264 T1262 pobj state,in
R907 T1265 T1264 amod compound,state
R908 T1266 T1264 compound heterozygote,state
R909 T1267 T1222 punct .,report
R910 T1401 T1400 prep of,Generation
R911 T1402 T1403 compound Xpd,Heterozygotes
R912 T1403 T1401 pobj Heterozygotes,of
R913 T1404 T1403 compound Compound,Heterozygotes
R914 T1406 T1407 nsubj We,generated
R915 T1408 T1409 det an,allele
R916 T1409 T1407 dobj allele,generated
R917 T1410 T1409 nmod Xpd,allele
R918 T1411 T1409 amod knock,allele
R919 T1412 T1411 punct -,knock
R920 T1413 T1411 prt in,knock
R921 T1414 T1409 prep with,allele
R922 T1415 T1416 det a,mutation
R923 T1416 T1414 pobj mutation,with
R924 T1417 T1416 compound point,mutation
R925 T1418 T1416 acl encoding,mutation
R926 T1419 T1420 det a,change
R927 T1420 T1418 dobj change,encoding
R928 T1421 T1420 amod single,change
R929 T1422 T1423 compound amino,acid
R930 T1423 T1420 compound acid,change
R931 T1424 T1425 punct (,XPDG602D
R932 T1425 T1420 parataxis XPDG602D,change
R933 T1426 T1425 punct ),XPDG602D
R934 T1427 T1420 acl found,change
R935 T1428 T1427 prep in,found
R936 T1429 T1430 det the,patient
R937 T1430 T1428 pobj patient,in
R938 T1431 T1430 compound XPCS,patient
R939 T1432 T1430 appos XPCS2,patient
R940 T1433 T1434 punct (,1A
R941 T1434 T1407 parataxis 1A,generated
R942 T1435 T1434 compound Figure,1A
R943 T1436 T1437 punct –,1C
R944 T1437 T1434 prep 1C,1A
R945 T1438 T1434 punct ),1A
R946 T1439 T1407 punct .,generated
R947 T1441 T1442 compound mRNA,expression
R948 T1442 T1443 nsubjpass expression,detected
R949 T1444 T1442 prep from,expression
R950 T1445 T1446 det the,allele
R951 T1446 T1444 pobj allele,from
R952 T1447 T1446 amod targeted,allele
R953 T1448 T1443 aux could,detected
R954 T1449 T1443 auxpass be,detected
R955 T1450 T1443 prep in,detected
R956 T1451 T1452 amod embryonic,cells
R957 T1452 T1450 pobj cells,in
R958 T1453 T1452 compound stem,cells
R959 T1454 T1443 prep by,detected
R960 T1455 T1456 compound RT,PCR
R961 T1456 T1454 pobj PCR,by
R962 T1457 T1456 punct -,PCR
R963 T1458 T1459 punct (,1D
R964 T1459 T1443 parataxis 1D,detected
R965 T1460 T1459 compound Figure,1D
R966 T1461 T1459 punct ),1D
R967 T1462 T1443 punct ", ",detected
R968 T1463 T1464 mark although,reduced
R969 T1464 T1443 advcl reduced,detected
R970 T1465 T1464 nsubjpass expression,reduced
R971 T1466 T1464 auxpass was,reduced
R972 T1467 T1468 advmod approximately,5
R973 T1468 T1464 npadvmod 5,reduced
R974 T1469 T1468 punct -,5
R975 T1470 T1468 advmod fold,5
R976 T1471 T1464 advcl relative,reduced
R977 T1472 T1471 prep to,relative
R978 T1473 T1474 compound wt,levels
R979 T1474 T1472 pobj levels,to
R980 T1475 T1474 compound mRNA,levels
R981 T1476 T1474 compound transcript,levels
R982 T1477 T1478 mark as,determined
R983 T1478 T1464 advcl determined,reduced
R984 T1479 T1478 prep by,determined
R985 T1480 T1479 pobj Northern,by
R986 T1481 T1480 amod blotting,Northern
R987 T1482 T1480 prep of,Northern
R988 T1483 T1482 pobj RNA,of
R989 T1484 T1483 prep from,RNA
R990 T1485 T1486 det the,testis
R991 T1486 T1484 pobj testis,from
R992 T1487 T1486 prep of,testis
R993 T1488 T1489 amod heterozygous,animals
R994 T1489 T1487 pobj animals,of
R995 T1490 T1491 punct (,1E
R996 T1491 T1443 parataxis 1E,detected
R997 T1492 T1491 compound Figure,1E
R998 T1493 T1491 punct ),1E
R999 T1494 T1443 punct .,detected