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PMC:1584416 / 17108-24237 JSONTXT 5 Projects

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Id Subject Object Predicate Lexical cue
T3312 0-9 JJ denotes Molecular
T3313 10-20 NNS denotes Mechanisms
T3314 21-23 IN denotes of
T3315 24-33 JJ denotes Biallelic
T3316 34-41 NNS denotes Effects
T3317 41-340 sentence denotes We next turned to UV-based cellular assays including unscheduled DNA synthesis after UV irradiation (UV-UDS), recovery of RNA synthesis after UV irradiation (UV-RRS), and UV survival, which report on the NER subpathways (global genome NER and transcription-coupled NER) and total NER, respectively.
T3318 42-44 PRP denotes We
T3320 45-49 RB denotes next
T3319 50-56 VBD denotes turned
T3321 57-59 IN denotes to
T3322 60-62 NN denotes UV
T3324 62-63 HYPH denotes -
T3323 63-68 VBN denotes based
T3326 69-77 JJ denotes cellular
T3325 78-84 NNS denotes assays
T3327 85-94 VBG denotes including
T3328 95-106 JJ denotes unscheduled
T3330 107-110 NN denotes DNA
T3329 111-120 NN denotes synthesis
T3331 121-126 IN denotes after
T3332 127-129 NN denotes UV
T3333 130-141 NN denotes irradiation
T3334 142-143 -LRB- denotes (
T3336 143-145 NN denotes UV
T3337 145-146 HYPH denotes -
T3335 146-149 NN denotes UDS
T3338 149-150 -RRB- denotes )
T3339 150-152 , denotes ,
T3340 152-160 NN denotes recovery
T3341 161-163 IN denotes of
T3342 164-167 NN denotes RNA
T3343 168-177 NN denotes synthesis
T3344 178-183 IN denotes after
T3345 184-186 NN denotes UV
T3346 187-198 NN denotes irradiation
T3347 199-200 -LRB- denotes (
T3349 200-202 NN denotes UV
T3350 202-203 HYPH denotes -
T3348 203-206 NN denotes RRS
T3351 206-207 -RRB- denotes )
T3352 207-209 , denotes ,
T3353 209-212 CC denotes and
T3354 213-215 NN denotes UV
T3355 216-224 NN denotes survival
T3356 224-226 , denotes ,
T3357 226-231 WDT denotes which
T3358 232-238 VBP denotes report
T3359 239-241 IN denotes on
T3360 242-245 DT denotes the
T3362 246-249 NN denotes NER
T3361 250-261 NNS denotes subpathways
T3363 262-263 -LRB- denotes (
T3365 263-269 JJ denotes global
T3366 270-276 NN denotes genome
T3364 277-280 NN denotes NER
T3367 281-284 CC denotes and
T3368 285-298 NN denotes transcription
T3370 298-299 HYPH denotes -
T3369 299-306 VBN denotes coupled
T3371 307-310 NN denotes NER
T3372 310-311 -RRB- denotes )
T3373 312-315 CC denotes and
T3374 316-321 JJ denotes total
T3375 322-325 NN denotes NER
T3376 325-327 , denotes ,
T3377 327-339 RB denotes respectively
T3378 339-340 . denotes .
T3379 340-466 sentence denotes In none of these assays was the response to UV improved in compound heterozygotes relative to TTD homozygotes (Figure 4A–4C).
T3380 341-343 IN denotes In
T3382 344-348 NN denotes none
T3383 349-351 IN denotes of
T3384 352-357 DT denotes these
T3385 358-364 NNS denotes assays
T3386 365-368 VBD denotes was
T3387 369-372 DT denotes the
T3388 373-381 NN denotes response
T3389 382-384 IN denotes to
T3390 385-387 NN denotes UV
T3381 388-396 VBN denotes improved
T3391 397-399 IN denotes in
T3392 400-408 NN denotes compound
T3393 409-422 NNS denotes heterozygotes
T3394 423-431 JJ denotes relative
T3395 432-434 IN denotes to
T3396 435-438 NN denotes TTD
T3397 439-450 NNS denotes homozygotes
T3398 451-452 -LRB- denotes (
T3400 452-458 NN denotes Figure
T3399 459-461 NN denotes 4A
T3401 461-462 SYM denotes –
T3402 462-464 NN denotes 4C
T3403 464-465 -RRB- denotes )
T3404 465-466 . denotes .
T3405 466-812 sentence denotes However, unlike the in vivo TTD phenotypes described above, in which XpdTTD/TTD and XpdTTD/KO animals were indistinguishable, XpdTTD dosage effects were observed in UV survival, UV-UDS, and UV-RRS, indicating that cellular parameters as measured in fibroblasts here do not always correlate with the phenotype at the level of the intact organism.
T3406 467-474 RB denotes However
T3408 474-476 , denotes ,
T3409 476-482 IN denotes unlike
T3410 483-486 DT denotes the
T3412 487-489 FW denotes in
T3413 490-494 FW denotes vivo
T3414 495-498 NN denotes TTD
T3411 499-509 NNS denotes phenotypes
T3415 510-519 VBN denotes described
T3416 520-525 RB denotes above
T3417 525-527 , denotes ,
T3418 527-529 IN denotes in
T3420 530-535 WDT denotes which
T3421 536-542 NN denotes XpdTTD
T3423 542-543 HYPH denotes /
T3422 543-546 NN denotes TTD
T3425 547-550 CC denotes and
T3426 551-557 NN denotes XpdTTD
T3428 557-558 HYPH denotes /
T3427 558-560 NN denotes KO
T3424 561-568 NNS denotes animals
T3419 569-573 VBD denotes were
T3429 574-591 JJ denotes indistinguishable
T3430 591-593 , denotes ,
T3431 593-599 NN denotes XpdTTD
T3433 600-606 NN denotes dosage
T3432 607-614 NNS denotes effects
T3434 615-619 VBD denotes were
T3407 620-628 VBN denotes observed
T3435 629-631 IN denotes in
T3436 632-634 NN denotes UV
T3437 635-643 NN denotes survival
T3438 643-645 , denotes ,
T3439 645-647 NN denotes UV
T3441 647-648 HYPH denotes -
T3440 648-651 NN denotes UDS
T3442 651-653 , denotes ,
T3443 653-656 CC denotes and
T3444 657-659 NN denotes UV
T3446 659-660 HYPH denotes -
T3445 660-663 NN denotes RRS
T3447 663-665 , denotes ,
T3448 665-675 VBG denotes indicating
T3449 676-680 IN denotes that
T3451 681-689 JJ denotes cellular
T3452 690-700 NNS denotes parameters
T3453 701-703 IN denotes as
T3454 704-712 VBN denotes measured
T3455 713-715 IN denotes in
T3456 716-727 NNS denotes fibroblasts
T3457 728-732 RB denotes here
T3458 733-735 VBP denotes do
T3459 736-739 RB denotes not
T3460 740-746 RB denotes always
T3450 747-756 VB denotes correlate
T3461 757-761 IN denotes with
T3462 762-765 DT denotes the
T3463 766-775 NN denotes phenotype
T3464 776-778 IN denotes at
T3465 779-782 DT denotes the
T3466 783-788 NN denotes level
T3467 789-791 IN denotes of
T3468 792-795 DT denotes the
T3470 796-802 JJ denotes intact
T3469 803-811 NN denotes organism
T3471 811-812 . denotes .
T3472 812-935 sentence denotes XpdTTD/KO hemizygous cells were thus used as the baseline on which to compare the activity of compound heterozygous cells.
T3473 813-819 NN denotes XpdTTD
T3475 819-820 HYPH denotes /
T3474 820-822 NN denotes KO
T3477 823-833 JJ denotes hemizygous
T3476 834-839 NNS denotes cells
T3479 840-844 VBD denotes were
T3480 845-849 RB denotes thus
T3478 850-854 VBN denotes used
T3481 855-857 IN denotes as
T3482 858-861 DT denotes the
T3483 862-870 NN denotes baseline
T3484 871-873 IN denotes on
T3486 874-879 WDT denotes which
T3487 880-882 TO denotes to
T3485 883-890 VB denotes compare
T3488 891-894 DT denotes the
T3489 895-903 NN denotes activity
T3490 904-906 IN denotes of
T3491 907-915 NN denotes compound
T3493 916-928 JJ denotes heterozygous
T3492 929-934 NNS denotes cells
T3494 934-935 . denotes .
T3495 935-1142 sentence denotes Relative to XpdTTD/KO hemizygote cells, UV survival was improved by the homozygous lethal Xpd†XPCS allele in XpdTTD/†XPCS compound heterozygous cells and to a lesser degree by the Xpd†XP allele (Figure 4A).
T3496 936-944 JJ denotes Relative
T3498 945-947 IN denotes to
T3499 948-954 NN denotes XpdTTD
T3501 954-955 HYPH denotes /
T3500 955-957 NN denotes KO
T3503 958-968 NN denotes hemizygote
T3502 969-974 NNS denotes cells
T3504 974-976 , denotes ,
T3505 976-978 NN denotes UV
T3506 979-987 NN denotes survival
T3507 988-991 VBD denotes was
T3497 992-1000 VBN denotes improved
T3508 1001-1003 IN denotes by
T3509 1004-1007 DT denotes the
T3511 1008-1018 JJ denotes homozygous
T3512 1019-1025 JJ denotes lethal
T3513 1026-1034 NN denotes Xpd†XPCS
T3510 1035-1041 NN denotes allele
T3514 1042-1044 IN denotes in
T3515 1045-1051 NN denotes XpdTTD
T3517 1051-1052 HYPH denotes /
T3516 1052-1057 NN denotes †XPCS
T3519 1058-1066 NN denotes compound
T3520 1067-1079 JJ denotes heterozygous
T3518 1080-1085 NNS denotes cells
T3521 1086-1089 CC denotes and
T3522 1090-1092 IN denotes to
T3524 1093-1094 DT denotes a
T3526 1095-1101 JJR denotes lesser
T3525 1102-1108 NN denotes degree
T3523 1109-1111 IN denotes by
T3527 1112-1115 DT denotes the
T3529 1116-1122 NN denotes Xpd†XP
T3528 1123-1129 NN denotes allele
T3530 1130-1131 -LRB- denotes (
T3532 1131-1137 NN denotes Figure
T3531 1138-1140 NN denotes 4A
T3533 1140-1141 -RRB- denotes )
T3534 1141-1142 . denotes .
T3535 1142-1282 sentence denotes Because of embryonic and cellular lethality, we were unable to test UV survival associated exclusively with the Xpd†XPCS or Xpd†XP alleles.
T3536 1143-1150 IN denotes Because
T3538 1151-1153 IN denotes of
T3539 1154-1163 JJ denotes embryonic
T3541 1164-1167 CC denotes and
T3542 1168-1176 JJ denotes cellular
T3540 1177-1186 NN denotes lethality
T3543 1186-1188 , denotes ,
T3544 1188-1190 PRP denotes we
T3537 1191-1195 VBD denotes were
T3545 1196-1202 JJ denotes unable
T3546 1203-1205 TO denotes to
T3547 1206-1210 VB denotes test
T3548 1211-1213 NN denotes UV
T3549 1214-1222 NN denotes survival
T3550 1223-1233 VBN denotes associated
T3551 1234-1245 RB denotes exclusively
T3552 1246-1250 IN denotes with
T3553 1251-1254 DT denotes the
T3555 1255-1263 NN denotes Xpd†XPCS
T3556 1264-1266 CC denotes or
T3557 1267-1273 NN denotes Xpd†XP
T3554 1274-1281 NNS denotes alleles
T3558 1281-1282 . denotes .
T3559 1282-1524 sentence denotes However, homozygous XPDXP (XPDR683W) and hemizygous XPDXPCS (XPDG602D) human cells are known to be highly sensitive to UV [19,25], as are cells from a homozygous viable XpdXPCS/XPCS (XPDG602D/G602D) mouse model (Figure 4A, dotted line) [23].
T3560 1283-1290 RB denotes However
T3562 1290-1292 , denotes ,
T3563 1292-1302 JJ denotes homozygous
T3564 1303-1308 NN denotes XPDXP
T3566 1309-1310 -LRB- denotes (
T3567 1310-1318 NN denotes XPDR683W
T3568 1318-1319 -RRB- denotes )
T3569 1320-1323 CC denotes and
T3570 1324-1334 JJ denotes hemizygous
T3571 1335-1342 NN denotes XPDXPCS
T3572 1343-1344 -LRB- denotes (
T3573 1344-1352 NN denotes XPDG602D
T3574 1352-1353 -RRB- denotes )
T3575 1354-1359 JJ denotes human
T3565 1360-1365 NNS denotes cells
T3576 1366-1369 VBP denotes are
T3561 1370-1375 VBN denotes known
T3577 1376-1378 TO denotes to
T3578 1379-1381 VB denotes be
T3579 1382-1388 RB denotes highly
T3580 1389-1398 JJ denotes sensitive
T3581 1399-1401 IN denotes to
T3582 1402-1404 NN denotes UV
T3583 1405-1406 -LRB- denotes [
T3585 1406-1408 CD denotes 19
T3586 1408-1409 , denotes ,
T3584 1409-1411 CD denotes 25
T3587 1411-1412 -RRB- denotes ]
T3588 1412-1414 , denotes ,
T3589 1414-1416 IN denotes as
T3590 1417-1420 VBP denotes are
T3591 1421-1426 NNS denotes cells
T3592 1427-1431 IN denotes from
T3593 1432-1433 DT denotes a
T3595 1434-1444 JJ denotes homozygous
T3596 1445-1451 JJ denotes viable
T3597 1452-1459 NN denotes XpdXPCS
T3599 1459-1460 HYPH denotes /
T3598 1460-1464 NN denotes XPCS
T3600 1465-1466 -LRB- denotes (
T3602 1466-1474 NN denotes XPDG602D
T3603 1474-1475 HYPH denotes /
T3601 1475-1480 NN denotes G602D
T3604 1480-1481 -RRB- denotes )
T3605 1482-1487 NN denotes mouse
T3594 1488-1493 NN denotes model
T3606 1494-1495 -LRB- denotes (
T3608 1495-1501 NN denotes Figure
T3607 1502-1504 NN denotes 4A
T3609 1504-1506 , denotes ,
T3610 1506-1512 VBN denotes dotted
T3611 1513-1517 NN denotes line
T3612 1517-1518 -RRB- denotes )
T3613 1519-1520 -LRB- denotes [
T3614 1520-1522 CD denotes 23
T3615 1522-1523 -RRB- denotes ]
T3616 1523-1524 . denotes .
T3617 1524-1685 sentence denotes Thus, the survival of XpdTTD/†XPCS (and XpdTTD/†XP) cells likely represents a level of UV resistance that neither mutant allele can impart on its own (Table 2).
T3618 1525-1529 RB denotes Thus
T3620 1529-1531 , denotes ,
T3621 1531-1534 DT denotes the
T3622 1535-1543 NN denotes survival
T3623 1544-1546 IN denotes of
T3624 1547-1553 NN denotes XpdTTD
T3626 1553-1554 HYPH denotes /
T3625 1554-1559 NN denotes †XPCS
T3628 1560-1561 -LRB- denotes (
T3629 1561-1564 CC denotes and
T3630 1565-1571 NN denotes XpdTTD
T3632 1571-1572 HYPH denotes /
T3631 1572-1575 NN denotes †XP
T3633 1575-1576 -RRB- denotes )
T3627 1577-1582 NNS denotes cells
T3634 1583-1589 RB denotes likely
T3619 1590-1600 VBZ denotes represents
T3635 1601-1602 DT denotes a
T3636 1603-1608 NN denotes level
T3637 1609-1611 IN denotes of
T3638 1612-1614 NN denotes UV
T3639 1615-1625 NN denotes resistance
T3640 1626-1630 WDT denotes that
T3642 1631-1638 CC denotes neither
T3644 1639-1645 JJ denotes mutant
T3643 1646-1652 NN denotes allele
T3645 1653-1656 MD denotes can
T3641 1657-1663 VB denotes impart
T3646 1664-1666 IN denotes on
T3647 1667-1670 PRP$ denotes its
T3648 1671-1674 NN denotes own
T3649 1675-1676 -LRB- denotes (
T3650 1676-1681 NN denotes Table
T3651 1682-1683 CD denotes 2
T3652 1683-1684 -RRB- denotes )
T3653 1684-1685 . denotes .
T3654 1685-1843 sentence denotes Significant effects of compound heterozygosity on NER subpathways relative to XpdTTD/KO cells were observed in XpdTTD/†XP cells but only for UV-UDS activity.
T3655 1686-1697 JJ denotes Significant
T3656 1698-1705 NNS denotes effects
T3658 1706-1708 IN denotes of
T3659 1709-1717 NN denotes compound
T3660 1718-1732 NN denotes heterozygosity
T3661 1733-1735 IN denotes on
T3662 1736-1739 NN denotes NER
T3663 1740-1751 NNS denotes subpathways
T3664 1752-1760 JJ denotes relative
T3665 1761-1763 IN denotes to
T3666 1764-1770 NN denotes XpdTTD
T3668 1770-1771 HYPH denotes /
T3667 1771-1773 NN denotes KO
T3669 1774-1779 NNS denotes cells
T3670 1780-1784 VBD denotes were
T3657 1785-1793 VBN denotes observed
T3671 1794-1796 IN denotes in
T3672 1797-1803 NN denotes XpdTTD
T3674 1803-1804 HYPH denotes /
T3673 1804-1807 NN denotes †XP
T3675 1808-1813 NNS denotes cells
T3676 1814-1817 CC denotes but
T3677 1818-1822 RB denotes only
T3678 1823-1826 IN denotes for
T3679 1827-1829 NN denotes UV
T3681 1829-1830 HYPH denotes -
T3680 1830-1833 NN denotes UDS
T3682 1834-1842 NN denotes activity
T3683 1842-1843 . denotes .
T3684 1843-2092 sentence denotes Finally, none of the mutant TFIIH combinations (carrying alterations associated with TTD [XPDR722W], XPCS [XPDG602D], or XP [XPDR683W]) exhibited synergism in an in vitro NER reaction reconstituted with different mutant TFIIH complexes (Figure 4D).
T3685 1844-1851 RB denotes Finally
T3687 1851-1853 , denotes ,
T3688 1853-1857 NN denotes none
T3689 1858-1860 IN denotes of
T3690 1861-1864 DT denotes the
T3692 1865-1871 JJ denotes mutant
T3693 1872-1877 NN denotes TFIIH
T3691 1878-1890 NNS denotes combinations
T3694 1891-1892 -LRB- denotes (
T3695 1892-1900 VBG denotes carrying
T3696 1901-1912 NNS denotes alterations
T3697 1913-1923 VBN denotes associated
T3698 1924-1928 IN denotes with
T3699 1929-1932 NN denotes TTD
T3700 1933-1934 -LRB- denotes [
T3701 1934-1942 NN denotes XPDR722W
T3702 1942-1943 -RRB- denotes ]
T3703 1943-1945 , denotes ,
T3704 1945-1949 NN denotes XPCS
T3705 1950-1951 -LRB- denotes [
T3706 1951-1959 NN denotes XPDG602D
T3707 1959-1960 -RRB- denotes ]
T3708 1960-1962 , denotes ,
T3709 1962-1964 CC denotes or
T3710 1965-1967 NN denotes XP
T3711 1968-1969 -LRB- denotes [
T3712 1969-1977 NN denotes XPDR683W
T3713 1977-1978 -RRB- denotes ]
T3714 1978-1979 -RRB- denotes )
T3686 1980-1989 VBD denotes exhibited
T3715 1990-1999 NN denotes synergism
T3716 2000-2002 IN denotes in
T3717 2003-2005 DT denotes an
T3719 2006-2008 FW denotes in
T3720 2009-2014 FW denotes vitro
T3721 2015-2018 NN denotes NER
T3718 2019-2027 NN denotes reaction
T3722 2028-2041 VBN denotes reconstituted
T3723 2042-2046 IN denotes with
T3724 2047-2056 JJ denotes different
T3726 2057-2063 JJ denotes mutant
T3727 2064-2069 NN denotes TFIIH
T3725 2070-2079 NNS denotes complexes
T3728 2080-2081 -LRB- denotes (
T3730 2081-2087 NN denotes Figure
T3729 2088-2090 NN denotes 4D
T3731 2090-2091 -RRB- denotes )
T3732 2091-2092 . denotes .
T3733 2092-2327 sentence denotes Taken together, these data are consistent with interallelic complementation of UV sensitivity in cells but underscore the lack of any correlation between UV-related repair characteristics and TTD progeroid phenotypes in animal models.
T3734 2093-2098 VBN denotes Taken
T3736 2099-2107 RB denotes together
T3737 2107-2109 , denotes ,
T3738 2109-2114 DT denotes these
T3739 2115-2119 NNS denotes data
T3735 2120-2123 VBP denotes are
T3740 2124-2134 JJ denotes consistent
T3741 2135-2139 IN denotes with
T3742 2140-2152 JJ denotes interallelic
T3743 2153-2168 NN denotes complementation
T3744 2169-2171 IN denotes of
T3745 2172-2174 NN denotes UV
T3746 2175-2186 NN denotes sensitivity
T3747 2187-2189 IN denotes in
T3748 2190-2195 NNS denotes cells
T3749 2196-2199 CC denotes but
T3750 2200-2210 VBP denotes underscore
T3751 2211-2214 DT denotes the
T3752 2215-2219 NN denotes lack
T3753 2220-2222 IN denotes of
T3754 2223-2226 DT denotes any
T3755 2227-2238 NN denotes correlation
T3756 2239-2246 IN denotes between
T3757 2247-2249 NN denotes UV
T3759 2249-2250 HYPH denotes -
T3758 2250-2257 VBN denotes related
T3761 2258-2264 NN denotes repair
T3760 2265-2280 NNS denotes characteristics
T3762 2281-2284 CC denotes and
T3763 2285-2288 NN denotes TTD
T3765 2289-2298 NN denotes progeroid
T3764 2299-2309 NNS denotes phenotypes
T3766 2310-2312 IN denotes in
T3767 2313-2319 NN denotes animal
T3768 2320-2326 NNS denotes models
T3769 2326-2327 . denotes .
T3770 2327-2328 sentence denotes
T8564 2338-2343 NN denotes TFIIH
T8565 2344-2353 NNS denotes Functions
T8566 2354-2357 CC denotes and
T8567 2358-2368 NNS denotes Mechanisms
T8568 2369-2371 IN denotes of
T8569 2372-2375 NN denotes XPD
T8571 2375-2376 HYPH denotes -
T8570 2376-2386 VBN denotes Associated
T8573 2387-2394 NN denotes Disease
T8572 2395-2405 NN denotes Pleiotropy
T8574 2405-2449 sentence denotes (A) Cellular survival after UV irradiation.
T8575 2406-2407 -LRB- denotes (
T8576 2407-2408 LS denotes A
T8578 2408-2409 -RRB- denotes )
T8579 2410-2418 JJ denotes Cellular
T8577 2419-2427 NN denotes survival
T8580 2428-2433 IN denotes after
T8581 2434-2436 NN denotes UV
T8582 2437-2448 NN denotes irradiation
T8583 2448-2449 . denotes .
T8584 2449-2575 sentence denotes Rescue of hemizygous XpdTTD/KO survival by Xpd†XPCS and Xpd†XP alleles is illustrated by arrows marked A and B, respectively.
T8585 2450-2456 NN denotes Rescue
T8587 2457-2459 IN denotes of
T8588 2460-2470 JJ denotes hemizygous
T8590 2471-2477 NN denotes XpdTTD
T8592 2477-2478 HYPH denotes /
T8591 2478-2480 NN denotes KO
T8589 2481-2489 NN denotes survival
T8593 2490-2492 IN denotes by
T8594 2493-2501 NN denotes Xpd†XPCS
T8596 2502-2505 CC denotes and
T8597 2506-2512 NN denotes Xpd†XP
T8595 2513-2520 NNS denotes alleles
T8598 2521-2523 VBZ denotes is
T8586 2524-2535 VBN denotes illustrated
T8599 2536-2538 IN denotes by
T8600 2539-2545 NNS denotes arrows
T8601 2546-2552 VBN denotes marked
T8602 2553-2554 NN denotes A
T8603 2555-2558 CC denotes and
T8604 2559-2560 NN denotes B
T8605 2560-2562 , denotes ,
T8606 2562-2574 RB denotes respectively
T8607 2574-2575 . denotes .
T8608 2575-2713 sentence denotes UV survival of homozygous XpdXPCS/XPCS cells (asterisk) from the normally expressed viable allele (XpdXPCS) is depicted by a dotted line.
T8609 2576-2578 NN denotes UV
T8610 2579-2587 NN denotes survival
T8612 2588-2590 IN denotes of
T8613 2591-2601 JJ denotes homozygous
T8615 2602-2609 NN denotes XpdXPCS
T8617 2609-2610 HYPH denotes /
T8616 2610-2614 NN denotes XPCS
T8614 2615-2620 NNS denotes cells
T8618 2621-2622 -LRB- denotes (
T8619 2622-2630 NN denotes asterisk
T8620 2630-2631 -RRB- denotes )
T8621 2632-2636 IN denotes from
T8622 2637-2640 DT denotes the
T8624 2641-2649 RB denotes normally
T8625 2650-2659 VBN denotes expressed
T8626 2660-2666 JJ denotes viable
T8623 2667-2673 NN denotes allele
T8627 2674-2675 -LRB- denotes (
T8628 2675-2682 NN denotes XpdXPCS
T8629 2682-2683 -RRB- denotes )
T8630 2684-2686 VBZ denotes is
T8611 2687-2695 VBN denotes depicted
T8631 2696-2698 IN denotes by
T8632 2699-2700 DT denotes a
T8634 2701-2707 VBN denotes dotted
T8633 2708-2712 NN denotes line
T8635 2712-2713 . denotes .
T8636 2713-2845 sentence denotes Survival curves represent an average of four independent experiments; 1–2 cell lines per genotype were included in each experiment.
T8637 2714-2722 NN denotes Survival
T8638 2723-2729 NNS denotes curves
T8639 2730-2739 VBP denotes represent
T8641 2740-2742 DT denotes an
T8642 2743-2750 NN denotes average
T8643 2751-2753 IN denotes of
T8644 2754-2758 CD denotes four
T8646 2759-2770 JJ denotes independent
T8645 2771-2782 NNS denotes experiments
T8647 2782-2783 : denotes ;
T8648 2784-2785 CD denotes 1
T8650 2785-2786 SYM denotes –
T8649 2786-2787 CD denotes 2
T8652 2788-2792 NN denotes cell
T8651 2793-2798 NNS denotes lines
T8653 2799-2802 IN denotes per
T8654 2803-2811 NN denotes genotype
T8655 2812-2816 VBD denotes were
T8640 2817-2825 VBN denotes included
T8656 2826-2828 IN denotes in
T8657 2829-2833 DT denotes each
T8658 2834-2844 NN denotes experiment
T8659 2844-2845 . denotes .
T8660 2845-2890 sentence denotes Error bars indicate SEM between experiments.
T8661 2846-2851 NN denotes Error
T8662 2852-2856 NNS denotes bars
T8663 2857-2865 VBP denotes indicate
T8664 2866-2869 NN denotes SEM
T8665 2870-2877 IN denotes between
T8666 2878-2889 NNS denotes experiments
T8667 2889-2890 . denotes .
T8668 2890-2937 sentence denotes (B) UV-UDS, a measure of global genome repair.
T8669 2891-2892 -LRB- denotes (
T8670 2892-2893 LS denotes B
T8672 2893-2894 -RRB- denotes )
T8673 2895-2897 NN denotes UV
T8674 2897-2898 HYPH denotes -
T8671 2898-2901 NN denotes UDS
T8675 2901-2903 , denotes ,
T8676 2903-2904 DT denotes a
T8677 2905-2912 NN denotes measure
T8678 2913-2915 IN denotes of
T8679 2916-2922 JJ denotes global
T8681 2923-2929 NN denotes genome
T8680 2930-2936 NN denotes repair
T8682 2936-2937 . denotes .
T8683 2937-3106 sentence denotes Number of experiments: n = 15 (XpdTTD/TTD), n = 6 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8684 2938-2944 NN denotes Number
T8686 2945-2947 IN denotes of
T8687 2948-2959 NNS denotes experiments
T8688 2959-2961 : denotes :
T8689 2961-2962 NN denotes n
T8691 2963-2964 SYM denotes =
T8690 2965-2967 CD denotes 15
T8692 2968-2969 -LRB- denotes (
T8693 2969-2975 NN denotes XpdTTD
T8694 2975-2976 SYM denotes /
T8695 2976-2979 NN denotes TTD
T8696 2979-2980 -RRB- denotes )
T8697 2980-2982 , denotes ,
T8698 2982-2983 NN denotes n
T8700 2984-2985 SYM denotes =
T8699 2986-2987 CD denotes 6
T8701 2988-2989 -LRB- denotes (
T8703 2989-2995 NN denotes XpdTTD
T8704 2995-2996 HYPH denotes /
T8702 2996-2998 NN denotes KO
T8705 2998-2999 -RRB- denotes )
T8706 2999-3001 , denotes ,
T8707 3001-3002 NN denotes n
T8709 3003-3004 SYM denotes =
T8708 3005-3006 CD denotes 4
T8710 3007-3008 -LRB- denotes (
T8712 3008-3014 NN denotes XpdTTD
T8713 3014-3015 HYPH denotes /
T8711 3015-3020 NN denotes †XPCS
T8714 3021-3022 -RRB- denotes )
T8715 3022-3024 , denotes ,
T8716 3024-3025 NN denotes n
T8718 3026-3027 SYM denotes =
T8717 3028-3029 CD denotes 2
T8719 3030-3031 -LRB- denotes (
T8721 3031-3037 NN denotes XpdTTD
T8722 3037-3038 HYPH denotes /
T8720 3038-3041 NN denotes †XP
T8723 3042-3043 -RRB- denotes )
T8724 3043-3044 : denotes ;
T8725 3045-3046 CD denotes 1
T8727 3046-3047 SYM denotes –
T8726 3047-3048 CD denotes 2
T8729 3049-3053 NN denotes cell
T8728 3054-3059 NNS denotes lines
T8730 3060-3063 IN denotes per
T8731 3064-3072 NN denotes genotype
T8732 3073-3077 VBD denotes were
T8685 3078-3086 VBN denotes included
T8733 3087-3089 IN denotes in
T8734 3090-3094 DT denotes each
T8735 3095-3105 NN denotes experiment
T8736 3105-3106 . denotes .
T8737 3106-3226 sentence denotes The asterisk indicates significant difference with XpdTTD/TTD; crosses indicate significant differences with XpdTTD/KO.
T8738 3107-3110 DT denotes The
T8739 3111-3119 NN denotes asterisk
T8740 3120-3129 VBZ denotes indicates
T8742 3130-3141 JJ denotes significant
T8743 3142-3152 NN denotes difference
T8744 3153-3157 IN denotes with
T8745 3158-3164 NN denotes XpdTTD
T8747 3164-3165 HYPH denotes /
T8746 3165-3168 NN denotes TTD
T8748 3168-3169 : denotes ;
T8749 3170-3177 NNS denotes crosses
T8741 3178-3186 VBP denotes indicate
T8750 3187-3198 JJ denotes significant
T8751 3199-3210 NNS denotes differences
T8752 3211-3215 IN denotes with
T8753 3216-3222 NN denotes XpdTTD
T8755 3222-3223 HYPH denotes /
T8754 3223-3225 NN denotes KO
T8756 3225-3226 . denotes .
T8757 3226-3303 sentence denotes (C) UV-RRS, a measure of transcription-coupled repair of UV-induced lesions.
T8758 3227-3228 -LRB- denotes (
T8759 3228-3229 LS denotes C
T8761 3229-3230 -RRB- denotes )
T8762 3231-3233 NN denotes UV
T8763 3233-3234 HYPH denotes -
T8760 3234-3237 NN denotes RRS
T8764 3237-3239 , denotes ,
T8765 3239-3240 DT denotes a
T8766 3241-3248 NN denotes measure
T8767 3249-3251 IN denotes of
T8768 3252-3265 NN denotes transcription
T8770 3265-3266 HYPH denotes -
T8769 3266-3273 VBN denotes coupled
T8771 3274-3280 NN denotes repair
T8772 3281-3283 IN denotes of
T8773 3284-3286 NN denotes UV
T8775 3286-3287 HYPH denotes -
T8774 3287-3294 VBN denotes induced
T8776 3295-3302 NNS denotes lesions
T8777 3302-3303 . denotes .
T8778 3303-3471 sentence denotes Number of experiments: n = 7 (XpdTTD/TTD), n = 2 (XpdTTD/KO), n = 4 (XpdTTD/†XPCS ), n = 2 (XpdTTD/†XP ); 1–2 cell lines per genotype were included in each experiment.
T8779 3304-3310 NN denotes Number
T8781 3311-3313 IN denotes of
T8782 3314-3325 NNS denotes experiments
T8783 3325-3327 : denotes :
T8784 3327-3328 NN denotes n
T8786 3329-3330 SYM denotes =
T8785 3331-3332 CD denotes 7
T8787 3333-3334 -LRB- denotes (
T8789 3334-3340 NN denotes XpdTTD
T8790 3340-3341 HYPH denotes /
T8788 3341-3344 NN denotes TTD
T8791 3344-3345 -RRB- denotes )
T8792 3345-3347 , denotes ,
T8793 3347-3348 NN denotes n
T8795 3349-3350 SYM denotes =
T8794 3351-3352 CD denotes 2
T8796 3353-3354 -LRB- denotes (
T8798 3354-3360 NN denotes XpdTTD
T8799 3360-3361 HYPH denotes /
T8797 3361-3363 NN denotes KO
T8800 3363-3364 -RRB- denotes )
T8801 3364-3366 , denotes ,
T8802 3366-3367 NN denotes n
T8804 3368-3369 SYM denotes =
T8803 3370-3371 CD denotes 4
T8805 3372-3373 -LRB- denotes (
T8807 3373-3379 NN denotes XpdTTD
T8808 3379-3380 HYPH denotes /
T8806 3380-3385 NN denotes †XPCS
T8809 3386-3387 -RRB- denotes )
T8810 3387-3389 , denotes ,
T8811 3389-3390 NN denotes n
T8813 3391-3392 SYM denotes =
T8812 3393-3394 CD denotes 2
T8814 3395-3396 -LRB- denotes (
T8816 3396-3402 NN denotes XpdTTD
T8817 3402-3403 HYPH denotes /
T8815 3403-3406 NN denotes †XP
T8818 3407-3408 -RRB- denotes )
T8819 3408-3409 : denotes ;
T8820 3410-3411 CD denotes 1
T8822 3411-3412 SYM denotes –
T8821 3412-3413 CD denotes 2
T8824 3414-3418 NN denotes cell
T8823 3419-3424 NNS denotes lines
T8825 3425-3428 IN denotes per
T8826 3429-3437 NN denotes genotype
T8827 3438-3442 VBD denotes were
T8780 3443-3451 VBN denotes included
T8828 3452-3454 IN denotes in
T8829 3455-3459 DT denotes each
T8830 3460-3470 NN denotes experiment
T8831 3470-3471 . denotes .
T8832 3471-3578 sentence denotes (D) Incision/excision activity of combinations of altered TFIIH complexes in a reconstituted NER reaction.
T8833 3472-3473 -LRB- denotes (
T8834 3473-3474 LS denotes D
T8836 3474-3475 -RRB- denotes )
T8837 3476-3484 NN denotes Incision
T8839 3484-3485 HYPH denotes /
T8838 3485-3493 NN denotes excision
T8835 3494-3502 NN denotes activity
T8840 3503-3505 IN denotes of
T8841 3506-3518 NNS denotes combinations
T8842 3519-3521 IN denotes of
T8843 3522-3529 VBN denotes altered
T8845 3530-3535 NN denotes TFIIH
T8844 3536-3545 NNS denotes complexes
T8846 3546-3548 IN denotes in
T8847 3549-3550 DT denotes a
T8849 3551-3564 VBN denotes reconstituted
T8850 3565-3568 NN denotes NER
T8848 3569-3577 NN denotes reaction
T8851 3577-3578 . denotes .
T8852 3578-3832 sentence denotes Equal amounts of single or mixed populations of recombinant TFIIHs (containing XPD, XPB, p62, p52, His-p44, Flag-p34, cdk7, cyclin H, Mat1, and p8) were mixed with recombinant XPG, XPF/ERCC1, XPC/hHR23B, RPA, and a radiolabelled synthetic NER substrate.
T8853 3579-3584 JJ denotes Equal
T8854 3585-3592 NNS denotes amounts
T8856 3593-3595 IN denotes of
T8857 3596-3602 JJ denotes single
T8859 3603-3605 CC denotes or
T8860 3606-3611 JJ denotes mixed
T8858 3612-3623 NNS denotes populations
T8861 3624-3626 IN denotes of
T8862 3627-3638 JJ denotes recombinant
T8863 3639-3645 NNS denotes TFIIHs
T8864 3646-3647 -LRB- denotes (
T8865 3647-3657 VBG denotes containing
T8866 3658-3661 NN denotes XPD
T8867 3661-3663 , denotes ,
T8868 3663-3666 NN denotes XPB
T8869 3666-3668 , denotes ,
T8870 3668-3671 NN denotes p62
T8871 3671-3673 , denotes ,
T8872 3673-3676 NN denotes p52
T8873 3676-3678 , denotes ,
T8874 3678-3681 NN denotes His
T8876 3681-3682 HYPH denotes -
T8875 3682-3685 NN denotes p44
T8877 3685-3687 , denotes ,
T8878 3687-3691 NN denotes Flag
T8880 3691-3692 HYPH denotes -
T8879 3692-3695 NN denotes p34
T8881 3695-3697 , denotes ,
T8882 3697-3701 NN denotes cdk7
T8883 3701-3703 , denotes ,
T8884 3703-3709 NN denotes cyclin
T8885 3710-3711 NN denotes H
T8886 3711-3713 , denotes ,
T8887 3713-3717 NN denotes Mat1
T8888 3717-3719 , denotes ,
T8889 3719-3722 CC denotes and
T8890 3723-3725 NN denotes p8
T8891 3725-3726 -RRB- denotes )
T8892 3727-3731 VBD denotes were
T8855 3732-3737 VBN denotes mixed
T8893 3738-3742 IN denotes with
T8894 3743-3754 JJ denotes recombinant
T8895 3755-3758 NN denotes XPG
T8896 3758-3760 , denotes ,
T8897 3760-3763 NN denotes XPF
T8899 3763-3764 HYPH denotes /
T8898 3764-3769 NN denotes ERCC1
T8900 3769-3771 , denotes ,
T8901 3771-3774 NN denotes XPC
T8903 3774-3775 HYPH denotes /
T8902 3775-3781 NN denotes hHR23B
T8904 3781-3783 , denotes ,
T8905 3783-3786 NN denotes RPA
T8906 3786-3788 , denotes ,
T8907 3788-3791 CC denotes and
T8908 3792-3793 DT denotes a
T8910 3794-3807 VBN denotes radiolabelled
T8911 3808-3817 JJ denotes synthetic
T8912 3818-3821 NN denotes NER
T8909 3822-3831 NN denotes substrate
T8913 3831-3832 . denotes .
T8914 3832-3975 sentence denotes The excision products (26–34 nucleotides in length) were visualised at nucleotide resolution on a denaturing polyacrylamide gel as indicated .
T8915 3833-3836 DT denotes The
T8917 3837-3845 NN denotes excision
T8916 3846-3854 NNS denotes products
T8919 3855-3856 -LRB- denotes (
T8921 3856-3858 CD denotes 26
T8923 3858-3859 SYM denotes –
T8922 3859-3861 CD denotes 34
T8920 3862-3873 NNS denotes nucleotides
T8924 3874-3876 IN denotes in
T8925 3877-3883 NN denotes length
T8926 3883-3884 -RRB- denotes )
T8927 3885-3889 VBD denotes were
T8918 3890-3900 VBN denotes visualised
T8928 3901-3903 IN denotes at
T8929 3904-3914 NN denotes nucleotide
T8930 3915-3925 NN denotes resolution
T8931 3926-3928 IN denotes on
T8932 3929-3930 DT denotes a
T8934 3931-3941 VBG denotes denaturing
T8935 3942-3956 NN denotes polyacrylamide
T8933 3957-3960 NN denotes gel
T8936 3961-3963 IN denotes as
T8937 3964-3973 VBN denotes indicated
T8938 3974-3975 . denotes .
T8939 3975-4126 sentence denotes Note the weak activity corresponding to each single and combined TFIIH complex (lanes 3–8) relative to the wt (lane 1) and negative controls (lane 2).
T8940 3976-3980 VB denotes Note
T8941 3981-3984 DT denotes the
T8943 3985-3989 JJ denotes weak
T8942 3990-3998 NN denotes activity
T8944 3999-4012 VBG denotes corresponding
T8945 4013-4015 IN denotes to
T8946 4016-4020 DT denotes each
T8948 4021-4027 JJ denotes single
T8949 4028-4031 CC denotes and
T8950 4032-4040 VBN denotes combined
T8951 4041-4046 NN denotes TFIIH
T8947 4047-4054 NN denotes complex
T8952 4055-4056 -LRB- denotes (
T8954 4056-4061 NNS denotes lanes
T8953 4062-4063 CD denotes 3
T8955 4063-4064 SYM denotes –
T8956 4064-4065 CD denotes 8
T8957 4065-4066 -RRB- denotes )
T8958 4067-4075 JJ denotes relative
T8959 4076-4078 IN denotes to
T8960 4079-4082 DT denotes the
T8961 4083-4085 NN denotes wt
T8962 4086-4087 -LRB- denotes (
T8963 4087-4091 NN denotes lane
T8964 4092-4093 CD denotes 1
T8965 4093-4094 -RRB- denotes )
T8966 4095-4098 CC denotes and
T8967 4099-4107 JJ denotes negative
T8968 4108-4116 NNS denotes controls
T8969 4117-4118 -LRB- denotes (
T8970 4118-4122 NN denotes lane
T8971 4123-4124 CD denotes 2
T8972 4124-4125 -RRB- denotes )
T8973 4125-4126 . denotes .
T8974 4126-4339 sentence denotes (E) Xpd dose-dependent reduction of TFIIH in homozygous XpdTTD/TTD, hemizygous XpdTTD/KO, and compound heterozygous XpdTTD/†XPCS and XpdTTD/†XP cells by comparative immunofluorescence of the p62 subunit of TFIIH.
T8975 4127-4128 -LRB- denotes (
T8976 4128-4129 LS denotes E
T8978 4129-4130 -RRB- denotes )
T8979 4131-4134 NN denotes Xpd
T8980 4135-4139 NN denotes dose
T8982 4139-4140 HYPH denotes -
T8981 4140-4149 JJ denotes dependent
T8977 4150-4159 NN denotes reduction
T8983 4160-4162 IN denotes of
T8984 4163-4168 NN denotes TFIIH
T8985 4169-4171 IN denotes in
T8986 4172-4182 JJ denotes homozygous
T8988 4183-4189 NN denotes XpdTTD
T8989 4189-4190 HYPH denotes /
T8987 4190-4193 NN denotes TTD
T8991 4193-4195 , denotes ,
T8992 4195-4205 JJ denotes hemizygous
T8994 4206-4212 NN denotes XpdTTD
T8995 4212-4213 HYPH denotes /
T8993 4213-4215 NN denotes KO
T8996 4215-4217 , denotes ,
T8997 4217-4220 CC denotes and
T8998 4221-4229 NN denotes compound
T9000 4230-4242 JJ denotes heterozygous
T9001 4243-4249 NN denotes XpdTTD
T9002 4249-4250 HYPH denotes /
T8999 4250-4255 NN denotes †XPCS
T9003 4256-4259 CC denotes and
T9004 4260-4266 NN denotes XpdTTD
T9006 4266-4267 HYPH denotes /
T9005 4267-4270 NN denotes †XP
T8990 4271-4276 NNS denotes cells
T9007 4277-4279 IN denotes by
T9008 4280-4291 JJ denotes comparative
T9009 4292-4310 NN denotes immunofluorescence
T9010 4311-4313 IN denotes of
T9011 4314-4317 DT denotes the
T9013 4318-4321 NN denotes p62
T9012 4322-4329 NN denotes subunit
T9014 4330-4332 IN denotes of
T9015 4333-4338 NN denotes TFIIH
T9016 4338-4339 . denotes .
T9017 4339-4757 sentence denotes Roman numerals represent different microscopic slides and Arabic numerals different cell lines labelled as follows: (I) wt cells (1) labelled with 2-μm beads, XpdTTD/TTD cells (2) with 0.79-μm beads, and XpdTTD/KO cells (3) with no beads; (II) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XPCS cells (4) with no beads; and (III) wt cells (1) labelled with 0.79-μm beads and XpdTTD/†XP cells (5) with no beads.
T9018 4340-4345 JJ denotes Roman
T9019 4346-4354 NNS denotes numerals
T9020 4355-4364 VBP denotes represent
T9021 4365-4374 JJ denotes different
T9023 4375-4386 JJ denotes microscopic
T9022 4387-4393 NNS denotes slides
T9024 4394-4397 CC denotes and
T9025 4398-4404 JJ denotes Arabic
T9026 4405-4413 NNS denotes numerals
T9028 4414-4423 JJ denotes different
T9029 4424-4428 NN denotes cell
T9027 4429-4434 NNS denotes lines
T9030 4435-4443 VBN denotes labelled
T9031 4444-4446 IN denotes as
T9032 4447-4454 VBZ denotes follows
T9033 4454-4456 : denotes :
T9034 4456-4457 -LRB- denotes (
T9035 4457-4458 LS denotes I
T9037 4458-4459 -RRB- denotes )
T9038 4460-4462 NN denotes wt
T9036 4463-4468 NNS denotes cells
T9039 4469-4470 -LRB- denotes (
T9040 4470-4471 CD denotes 1
T9041 4471-4472 -RRB- denotes )
T9042 4473-4481 VBN denotes labelled
T9043 4482-4486 IN denotes with
T9044 4487-4488 CD denotes 2
T9046 4488-4489 HYPH denotes -
T9045 4489-4491 NN denotes μm
T9047 4492-4497 NNS denotes beads
T9048 4497-4499 , denotes ,
T9049 4499-4505 NN denotes XpdTTD
T9051 4505-4506 HYPH denotes /
T9050 4506-4509 NN denotes TTD
T9052 4510-4515 NNS denotes cells
T9053 4516-4517 -LRB- denotes (
T9054 4517-4518 CD denotes 2
T9055 4518-4519 -RRB- denotes )
T9056 4520-4524 IN denotes with
T9057 4525-4529 CD denotes 0.79
T9059 4529-4530 HYPH denotes -
T9058 4530-4532 NN denotes μm
T9060 4533-4538 NNS denotes beads
T9061 4538-4540 , denotes ,
T9062 4540-4543 CC denotes and
T9063 4544-4550 NN denotes XpdTTD
T9065 4550-4551 HYPH denotes /
T9064 4551-4553 NN denotes KO
T9066 4554-4559 NNS denotes cells
T9067 4560-4561 -LRB- denotes (
T9068 4561-4562 CD denotes 3
T9069 4562-4563 -RRB- denotes )
T9070 4564-4568 IN denotes with
T9071 4569-4571 DT denotes no
T9072 4572-4577 NNS denotes beads
T9073 4577-4578 : denotes ;
T9074 4579-4580 -LRB- denotes (
T9075 4580-4582 LS denotes II
T9077 4582-4583 -RRB- denotes )
T9078 4584-4586 NN denotes wt
T9076 4587-4592 NNS denotes cells
T9079 4593-4594 -LRB- denotes (
T9080 4594-4595 CD denotes 1
T9081 4595-4596 -RRB- denotes )
T9082 4597-4605 VBN denotes labelled
T9083 4606-4610 IN denotes with
T9084 4611-4615 CD denotes 0.79
T9086 4615-4616 HYPH denotes -
T9085 4616-4618 NN denotes μm
T9087 4619-4624 NNS denotes beads
T9088 4625-4628 CC denotes and
T9089 4629-4635 NN denotes XpdTTD
T9091 4635-4636 HYPH denotes /
T9090 4636-4641 NN denotes †XPCS
T9092 4642-4647 NNS denotes cells
T9093 4648-4649 -LRB- denotes (
T9094 4649-4650 CD denotes 4
T9095 4650-4651 -RRB- denotes )
T9096 4652-4656 IN denotes with
T9097 4657-4659 DT denotes no
T9098 4660-4665 NNS denotes beads
T9099 4665-4666 : denotes ;
T9100 4667-4670 CC denotes and
T9101 4671-4672 -LRB- denotes (
T9102 4672-4675 LS denotes III
T9104 4675-4676 -RRB- denotes )
T9105 4677-4679 NN denotes wt
T9103 4680-4685 NNS denotes cells
T9106 4686-4687 -LRB- denotes (
T9107 4687-4688 CD denotes 1
T9108 4688-4689 -RRB- denotes )
T9109 4690-4698 VBN denotes labelled
T9110 4699-4703 IN denotes with
T9111 4704-4708 CD denotes 0.79
T9113 4708-4709 HYPH denotes -
T9112 4709-4711 NN denotes μm
T9114 4712-4717 NNS denotes beads
T9115 4718-4721 CC denotes and
T9116 4722-4728 NN denotes XpdTTD
T9118 4728-4729 HYPH denotes /
T9117 4729-4732 NN denotes †XP
T9119 4733-4738 NNS denotes cells
T9120 4739-4740 -LRB- denotes (
T9121 4740-4741 CD denotes 5
T9122 4741-4742 -RRB- denotes )
T9123 4743-4747 IN denotes with
T9124 4748-4750 DT denotes no
T9125 4751-4756 NNS denotes beads
T9126 4756-4757 . denotes .
T9127 4757-4876 sentence denotes (F) Quantification of immunofluorescent signal from at least 50 nuclei per cell line and 2–6 experiments per genotype.
T9128 4758-4759 -LRB- denotes (
T9129 4759-4760 LS denotes F
T9131 4760-4761 -RRB- denotes )
T9130 4762-4776 NN denotes Quantification
T9132 4777-4779 IN denotes of
T9133 4780-4797 JJ denotes immunofluorescent
T9134 4798-4804 NN denotes signal
T9135 4805-4809 IN denotes from
T9136 4810-4812 RB denotes at
T9138 4813-4818 RBS denotes least
T9137 4819-4821 CD denotes 50
T9139 4822-4828 NNS denotes nuclei
T9140 4829-4832 IN denotes per
T9141 4833-4837 NN denotes cell
T9142 4838-4842 NN denotes line
T9143 4843-4846 CC denotes and
T9144 4847-4848 CD denotes 2
T9146 4848-4849 SYM denotes –
T9145 4849-4850 CD denotes 6
T9147 4851-4862 NNS denotes experiments
T9148 4863-4866 IN denotes per
T9149 4867-4875 NN denotes genotype
T9150 4875-4876 . denotes .
T9151 4876-4987 sentence denotes Bars representing cells analysed on the same microscopic slide are depicted side by side, with wt set at 100%.
T9152 4877-4881 NNS denotes Bars
T9154 4882-4894 VBG denotes representing
T9155 4895-4900 NNS denotes cells
T9156 4901-4909 VBN denotes analysed
T9157 4910-4912 IN denotes on
T9158 4913-4916 DT denotes the
T9160 4917-4921 JJ denotes same
T9161 4922-4933 JJ denotes microscopic
T9159 4934-4939 NN denotes slide
T9162 4940-4943 VBP denotes are
T9153 4944-4952 VBN denotes depicted
T9163 4953-4957 NN denotes side
T9164 4958-4960 IN denotes by
T9165 4961-4965 NN denotes side
T9166 4965-4967 , denotes ,
T9167 4967-4971 IN denotes with
T9168 4972-4974 NN denotes wt
T9169 4975-4978 VBN denotes set
T9170 4979-4981 IN denotes at
T9171 4982-4985 CD denotes 100
T9172 4985-4986 NN denotes %
T9173 4986-4987 . denotes .
T9174 4987-5142 sentence denotes The p-value indicates minimum significant difference between wt and the indicated cell lines analysed on the same microscopic slide within one experiment.
T9175 4988-4991 DT denotes The
T9177 4992-4993 NN denotes p
T9178 4993-4994 HYPH denotes -
T9176 4994-4999 NN denotes value
T9179 5000-5009 VBZ denotes indicates
T9180 5010-5017 JJ denotes minimum
T9182 5018-5029 JJ denotes significant
T9181 5030-5040 NN denotes difference
T9183 5041-5048 IN denotes between
T9184 5049-5051 NN denotes wt
T9185 5052-5055 CC denotes and
T9186 5056-5059 DT denotes the
T9188 5060-5069 VBN denotes indicated
T9189 5070-5074 NN denotes cell
T9187 5075-5080 NNS denotes lines
T9190 5081-5089 VBN denotes analysed
T9191 5090-5092 IN denotes on
T9192 5093-5096 DT denotes the
T9194 5097-5101 JJ denotes same
T9195 5102-5113 JJ denotes microscopic
T9193 5114-5119 NN denotes slide
T9196 5120-5126 IN denotes within
T9197 5127-5130 CD denotes one
T9198 5131-5141 NN denotes experiment
T9199 5141-5142 . denotes .
T3772 5143-5145 NN denotes Ne
T3771 5143-5152 sentence denotes Next we a
T3773 5145-5147 NNS denotes xt
T3774 5147-5148 : denotes
T3775 5148-5150 VBD denotes we
T3776 5151-5152 DT denotes a
T3778 5152-5154 NN denotes sk
T3777 5152-5162 sentence denotes sked wheth
T3779 5154-5155 VBZ denotes e
T3781 5155-5156 NN denotes d
T3782 5157-5159 IN denotes wh
T3783 5159-5160 NNS denotes e
T3780 5160-5161 VBP denotes t
T3784 5161-5162 IN denotes h
T3786 5162-5164 NN denotes er
T3785 5162-5166 sentence denotes er t
T3787 5165-5166 NN denotes t
T3789 5166-5167 DT denotes h
T3788 5166-5168 sentence denotes he
T3790 5167-5168 NN denotes e
T3791 5168-5169 sentence denotes
T3793 5169-5170 NN denotes X
T3792 5169-5172 sentence denotes Xpd
T3794 5170-5171 NN denotes p
T3795 5171-5172 NN denotes d
T3797 5172-5177 NN denotes †XPCS
T3796 5172-5191 sentence denotes †XPCS and Xpd†XP al
T3798 5178-5181 CC denotes and
T3799 5182-5185 NN denotes Xpd
T3800 5185-5188 NN denotes †XP
T3801 5189-5190 JJ denotes a
T3802 5190-5191 NN denotes l
T3804 5191-5192 NNS denotes l
T3803 5191-5209 sentence denotes leles, despite dec
T3805 5192-5193 VBP denotes e
T3806 5193-5196 NNS denotes les
T3807 5196-5198 , denotes ,
T3808 5198-5199 NN denotes d
T3809 5199-5201 NNS denotes es
T3810 5201-5202 NN denotes p
T3811 5202-5204 IN denotes it
T3812 5204-5205 NNS denotes e
T3813 5206-5207 VBN denotes d
T3814 5207-5208 NNS denotes e
T3815 5208-5209 NNS denotes c
T3817 5209-5211 JJ denotes re
T3816 5209-5217 sentence denotes reased m
T3818 5211-5212 NN denotes a
T3819 5212-5213 RBS denotes s
T3820 5213-5214 NNS denotes e
T3821 5214-5215 CC denotes d
T3822 5216-5217 NNS denotes m
T3826 5217-5220 NN denotes RNA
T3823 5217-5350 sentence denotes RNA levels, ameliorated TTD symptoms by increasing overall TFIIH levels in compound heterozygous XpdTTD/ †XPCS and XpdTTD/ †XP cells.
T3825 5221-5227 NNS denotes levels
T3827 5227-5229 , denotes ,
T3824 5229-5240 VBN denotes ameliorated
T3828 5241-5244 NN denotes TTD
T3829 5245-5253 NNS denotes symptoms
T3830 5254-5256 IN denotes by
T3831 5257-5267 VBG denotes increasing
T3833 5268-5275 JJ denotes overall
T3834 5276-5281 NN denotes TFIIH
T3832 5282-5288 NNS denotes levels
T3835 5289-5291 IN denotes in
T3836 5292-5300 NN denotes compound
T3838 5301-5313 JJ denotes heterozygous
T3839 5314-5320 NN denotes XpdTTD
T3841 5320-5321 HYPH denotes /
T3840 5321-5327 NN denotes  †XPCS
T3842 5328-5331 CC denotes and
T3843 5332-5338 NN denotes XpdTTD
T3845 5338-5339 HYPH denotes /
T3844 5339-5343 NN denotes  †XP
T3837 5344-5349 NNS denotes cells
T3846 5349-5350 . denotes .
T3847 5350-5572 sentence denotes Previously, using comparative immunohistochemistry, we and others have shown an up to 70% reduction of TFIIH levels in primary fibroblasts from patients with TTD compared with wt controls due to reduced stability [16,17].
T3848 5351-5361 RB denotes Previously
T3850 5361-5363 , denotes ,
T3851 5363-5368 VBG denotes using
T3852 5369-5380 JJ denotes comparative
T3853 5381-5401 NN denotes immunohistochemistry
T3854 5401-5403 , denotes ,
T3855 5403-5405 PRP denotes we
T3856 5406-5409 CC denotes and
T3857 5410-5416 NNS denotes others
T3858 5417-5421 VBP denotes have
T3849 5422-5427 VBN denotes shown
T3859 5428-5430 DT denotes an
T3861 5431-5433 IN denotes up
T3863 5434-5436 IN denotes to
T3862 5437-5439 CD denotes 70
T3864 5439-5440 NN denotes %
T3860 5441-5450 NN denotes reduction
T3865 5451-5453 IN denotes of
T3866 5454-5459 NN denotes TFIIH
T3867 5460-5466 NNS denotes levels
T3868 5467-5469 IN denotes in
T3869 5470-5477 JJ denotes primary
T3870 5478-5489 NNS denotes fibroblasts
T3871 5490-5494 IN denotes from
T3872 5495-5503 NNS denotes patients
T3873 5504-5508 IN denotes with
T3874 5509-5512 NN denotes TTD
T3875 5513-5521 VBN denotes compared
T3876 5522-5526 IN denotes with
T3877 5527-5529 NN denotes wt
T3878 5530-5538 NNS denotes controls
T3879 5539-5542 IN denotes due
T3880 5543-5545 IN denotes to
T3881 5546-5553 VBN denotes reduced
T3882 5554-5563 NN denotes stability
T3883 5564-5565 -LRB- denotes [
T3885 5565-5567 CD denotes 16
T3886 5567-5568 , denotes ,
T3884 5568-5570 CD denotes 17
T3887 5570-5571 -RRB- denotes ]
T3888 5571-5572 . denotes .
T3889 5572-5826 sentence denotes Despite overexpression of mRNA from the XpdTTD allele relative to the wt allele (Figure 1E), TFIIH protein levels were reduced by 50% in primary mouse XpdTTD/TTD fibroblasts (Figure 4E and 4F), thereby mimicking the situation in human patients with TTD.
T3890 5573-5580 IN denotes Despite
T3892 5581-5595 NN denotes overexpression
T3893 5596-5598 IN denotes of
T3894 5599-5603 NN denotes mRNA
T3895 5604-5608 IN denotes from
T3896 5609-5612 DT denotes the
T3898 5613-5619 NN denotes XpdTTD
T3897 5620-5626 NN denotes allele
T3899 5627-5635 JJ denotes relative
T3900 5636-5638 IN denotes to
T3901 5639-5642 DT denotes the
T3903 5643-5645 NN denotes wt
T3902 5646-5652 NN denotes allele
T3904 5653-5654 -LRB- denotes (
T3906 5654-5660 NN denotes Figure
T3905 5661-5663 NN denotes 1E
T3907 5663-5664 -RRB- denotes )
T3908 5664-5666 , denotes ,
T3909 5666-5671 NN denotes TFIIH
T3911 5672-5679 NN denotes protein
T3910 5680-5686 NNS denotes levels
T3912 5687-5691 VBD denotes were
T3891 5692-5699 VBN denotes reduced
T3913 5700-5702 IN denotes by
T3914 5703-5705 CD denotes 50
T3915 5705-5706 NN denotes %
T3916 5707-5709 IN denotes in
T3917 5710-5717 JJ denotes primary
T3919 5718-5723 NN denotes mouse
T3920 5724-5730 NN denotes XpdTTD
T3922 5730-5731 HYPH denotes /
T3921 5731-5734 NN denotes TTD
T3918 5735-5746 NNS denotes fibroblasts
T3923 5747-5748 -LRB- denotes (
T3925 5748-5754 NN denotes Figure
T3924 5755-5757 NN denotes 4E
T3926 5758-5761 CC denotes and
T3927 5762-5764 NN denotes 4F
T3928 5764-5765 -RRB- denotes )
T3929 5765-5767 , denotes ,
T3930 5767-5774 RB denotes thereby
T3931 5775-5784 VBG denotes mimicking
T3932 5785-5788 DT denotes the
T3933 5789-5798 NN denotes situation
T3934 5799-5801 IN denotes in
T3935 5802-5807 JJ denotes human
T3936 5808-5816 NNS denotes patients
T3937 5817-5821 IN denotes with
T3938 5822-5825 NN denotes TTD
T3939 5825-5826 . denotes .
T3940 5826-5955 sentence denotes In accordance with the gene dosage, a further reduction of up to 70% of the wt level was observed in hemizygous XpdTTD/KO cells.
T3941 5827-5829 IN denotes In
T3943 5830-5840 NN denotes accordance
T3944 5841-5845 IN denotes with
T3945 5846-5849 DT denotes the
T3947 5850-5854 NN denotes gene
T3946 5855-5861 NN denotes dosage
T3948 5861-5863 , denotes ,
T3949 5863-5864 DT denotes a
T3951 5865-5872 JJ denotes further
T3950 5873-5882 NN denotes reduction
T3952 5883-5885 IN denotes of
T3953 5886-5888 IN denotes up
T3955 5889-5891 IN denotes to
T3954 5892-5894 CD denotes 70
T3956 5894-5895 NN denotes %
T3957 5896-5898 IN denotes of
T3958 5899-5902 DT denotes the
T3960 5903-5905 NN denotes wt
T3959 5906-5911 NN denotes level
T3961 5912-5915 VBD denotes was
T3942 5916-5924 VBN denotes observed
T3962 5925-5927 IN denotes in
T3963 5928-5938 JJ denotes hemizygous
T3965 5939-5945 NN denotes XpdTTD
T3967 5945-5946 HYPH denotes /
T3966 5946-5948 NN denotes KO
T3964 5949-5954 NNS denotes cells
T3968 5954-5955 . denotes .
T3969 5955-6149 sentence denotes Consistent with low mRNA expression levels, neither the Xpd†XPCS nor the Xpd†XP allele was able to restore TFIIH abundance to wt levels in XpdTTD compound heterozygote cells (Figure 4E and 4F).
T3970 5956-5966 JJ denotes Consistent
T3972 5967-5971 IN denotes with
T3973 5972-5975 JJ denotes low
T3975 5976-5980 NN denotes mRNA
T3976 5981-5991 NN denotes expression
T3974 5992-5998 NNS denotes levels
T3977 5998-6000 , denotes ,
T3978 6000-6007 CC denotes neither
T3980 6008-6011 DT denotes the
T3981 6012-6020 NN denotes Xpd†XPCS
T3982 6021-6024 CC denotes nor
T3983 6025-6028 DT denotes the
T3984 6029-6035 NN denotes Xpd†XP
T3979 6036-6042 NN denotes allele
T3971 6043-6046 VBD denotes was
T3985 6047-6051 JJ denotes able
T3986 6052-6054 TO denotes to
T3987 6055-6062 VB denotes restore
T3988 6063-6068 NN denotes TFIIH
T3989 6069-6078 NN denotes abundance
T3990 6079-6081 IN denotes to
T3991 6082-6084 NN denotes wt
T3992 6085-6091 NNS denotes levels
T3993 6092-6094 IN denotes in
T3994 6095-6101 NN denotes XpdTTD
T3996 6102-6110 NN denotes compound
T3997 6111-6123 NN denotes heterozygote
T3995 6124-6129 NNS denotes cells
T3998 6130-6131 -LRB- denotes (
T4000 6131-6137 NN denotes Figure
T3999 6138-6140 NN denotes 4E
T4001 6141-6144 CC denotes and
T4002 6145-6147 NN denotes 4F
T4003 6147-6148 -RRB- denotes )
T4004 6148-6149 . denotes .
T4005 6149-6426 sentence denotes Thus, the improved UV survival observed in compound heterozygote cells (Figure 4A) and likely the rescue of TTD progeroid symptoms (Figure 3) were not due to normalisation of TFIIH levels, suggesting a qualitative rather than a quantitative effect on these phenotypes in vivo.
T4006 6150-6154 RB denotes Thus
T4008 6154-6156 , denotes ,
T4009 6156-6159 DT denotes the
T4011 6160-6168 VBN denotes improved
T4012 6169-6171 NN denotes UV
T4010 6172-6180 NN denotes survival
T4013 6181-6189 VBN denotes observed
T4014 6190-6192 IN denotes in
T4015 6193-6201 NN denotes compound
T4017 6202-6214 NN denotes heterozygote
T4016 6215-6220 NNS denotes cells
T4018 6221-6222 -LRB- denotes (
T4020 6222-6228 NN denotes Figure
T4019 6229-6231 NN denotes 4A
T4021 6231-6232 -RRB- denotes )
T4022 6233-6236 CC denotes and
T4023 6237-6243 RB denotes likely
T4025 6244-6247 DT denotes the
T4024 6248-6254 NN denotes rescue
T4026 6255-6257 IN denotes of
T4027 6258-6261 NN denotes TTD
T4029 6262-6271 NN denotes progeroid
T4028 6272-6280 NNS denotes symptoms
T4030 6281-6282 -LRB- denotes (
T4031 6282-6288 NN denotes Figure
T4032 6289-6290 CD denotes 3
T4033 6290-6291 -RRB- denotes )
T4007 6292-6296 VBD denotes were
T4034 6297-6300 RB denotes not
T4035 6301-6304 IN denotes due
T4036 6305-6307 IN denotes to
T4037 6308-6321 NN denotes normalisation
T4038 6322-6324 IN denotes of
T4039 6325-6330 NN denotes TFIIH
T4040 6331-6337 NNS denotes levels
T4041 6337-6339 , denotes ,
T4042 6339-6349 VBG denotes suggesting
T4043 6350-6351 DT denotes a
T4044 6352-6363 JJ denotes qualitative
T4046 6364-6370 RB denotes rather
T4047 6371-6375 IN denotes than
T4048 6376-6377 DT denotes a
T4049 6378-6390 JJ denotes quantitative
T4045 6391-6397 NN denotes effect
T4050 6398-6400 IN denotes on
T4051 6401-6406 DT denotes these
T4052 6407-6417 NNS denotes phenotypes
T4053 6418-6420 FW denotes in
T4054 6421-6425 FW denotes vivo
T4055 6425-6426 . denotes .
T4056 6426-6575 sentence denotes In contrast, the level of XPCS mRNA expression did affect the ability of the encoded protein (XPDG602D) to restore the TTD hair phenotype to normal.
T4057 6427-6429 IN denotes In
T4059 6430-6438 NN denotes contrast
T4060 6438-6440 , denotes ,
T4061 6440-6443 DT denotes the
T4062 6444-6449 NN denotes level
T4063 6450-6452 IN denotes of
T4064 6453-6457 NN denotes XPCS
T4066 6458-6462 NN denotes mRNA
T4065 6463-6473 NN denotes expression
T4067 6474-6477 VBD denotes did
T4058 6478-6484 VB denotes affect
T4068 6485-6488 DT denotes the
T4069 6489-6496 NN denotes ability
T4070 6497-6499 IN denotes of
T4071 6500-6503 DT denotes the
T4073 6504-6511 VBN denotes encoded
T4072 6512-6519 NN denotes protein
T4074 6520-6521 -LRB- denotes (
T4075 6521-6529 NN denotes XPDG602D
T4076 6529-6530 -RRB- denotes )
T4077 6531-6533 TO denotes to
T4078 6534-6541 VB denotes restore
T4079 6542-6545 DT denotes the
T4081 6546-6549 NN denotes TTD
T4082 6550-6554 NN denotes hair
T4080 6555-6564 NN denotes phenotype
T4083 6565-6567 IN denotes to
T4084 6568-6574 JJ denotes normal
T4085 6574-6575 . denotes .
T4086 6575-6838 sentence denotes Notably, XpdTTD/ †XPCS animals had a partial TTD hair phenotype, correlating with low levels of Xpd†XPCS expression, whereas XpdTTD/XPCS animals had wt hair, correlating with normal expression levels from the viable XpdXPCS allele (Table 2 and unpublished data).
T4087 6576-6583 RB denotes Notably
T4089 6583-6585 , denotes ,
T4090 6585-6591 NN denotes XpdTTD
T4092 6591-6592 HYPH denotes /
T4091 6592-6598 NN denotes  †XPCS
T4093 6599-6606 NNS denotes animals
T4088 6607-6610 VBD denotes had
T4094 6611-6612 DT denotes a
T4096 6613-6620 JJ denotes partial
T4097 6621-6624 NN denotes TTD
T4098 6625-6629 NN denotes hair
T4095 6630-6639 NN denotes phenotype
T4099 6639-6641 , denotes ,
T4100 6641-6652 VBG denotes correlating
T4101 6653-6657 IN denotes with
T4102 6658-6661 JJ denotes low
T4103 6662-6668 NNS denotes levels
T4104 6669-6671 IN denotes of
T4105 6672-6680 NN denotes Xpd†XPCS
T4106 6681-6691 NN denotes expression
T4107 6691-6693 , denotes ,
T4108 6693-6700 IN denotes whereas
T4110 6701-6707 NN denotes XpdTTD
T4112 6707-6708 HYPH denotes /
T4111 6708-6712 NN denotes XPCS
T4113 6713-6720 NNS denotes animals
T4109 6721-6724 VBD denotes had
T4114 6725-6727 NN denotes wt
T4115 6728-6732 NN denotes hair
T4116 6732-6734 , denotes ,
T4117 6734-6745 VBG denotes correlating
T4118 6746-6750 IN denotes with
T4119 6751-6757 JJ denotes normal
T4121 6758-6768 NN denotes expression
T4120 6769-6775 NNS denotes levels
T4122 6776-6780 IN denotes from
T4123 6781-6784 DT denotes the
T4125 6785-6791 JJ denotes viable
T4126 6792-6799 NN denotes XpdXPCS
T4124 6800-6806 NN denotes allele
T4127 6807-6808 -LRB- denotes (
T4128 6808-6813 NN denotes Table
T4129 6814-6815 CD denotes 2
T4130 6816-6819 CC denotes and
T4131 6820-6831 JJ denotes unpublished
T4132 6832-6836 NNS denotes data
T4133 6836-6837 -RRB- denotes )
T4134 6837-6838 . denotes .
T4135 6838-6966 sentence denotes Thus, the range of expression levels from these two mutant alleles affected their ability to complement some phenotypes (hair).
T4136 6839-6843 RB denotes Thus
T4138 6843-6845 , denotes ,
T4139 6845-6848 DT denotes the
T4140 6849-6854 NN denotes range
T4141 6855-6857 IN denotes of
T4142 6858-6868 NN denotes expression
T4143 6869-6875 NNS denotes levels
T4144 6876-6880 IN denotes from
T4145 6881-6886 DT denotes these
T4147 6887-6890 CD denotes two
T4148 6891-6897 JJ denotes mutant
T4146 6898-6905 NNS denotes alleles
T4137 6906-6914 VBD denotes affected
T4149 6915-6920 PRP$ denotes their
T4150 6921-6928 NN denotes ability
T4151 6929-6931 TO denotes to
T4152 6932-6942 VB denotes complement
T4153 6943-6947 DT denotes some
T4154 6948-6958 NNS denotes phenotypes
T4155 6959-6960 -LRB- denotes (
T4156 6960-6964 NN denotes hair
T4157 6964-6965 -RRB- denotes )
T4158 6965-6966 . denotes .
T4159 6966-7129 sentence denotes An overview of the functional relationships between Xpd alleles, phenotypes, and the presumed underlying TFIIH function in mice and cells is presented in Table 2.
T4160 6967-6969 DT denotes An
T4161 6970-6978 NN denotes overview
T4163 6979-6981 IN denotes of
T4164 6982-6985 DT denotes the
T4166 6986-6996 JJ denotes functional
T4165 6997-7010 NNS denotes relationships
T4167 7011-7018 IN denotes between
T4168 7019-7022 NN denotes Xpd
T4169 7023-7030 NNS denotes alleles
T4170 7030-7032 , denotes ,
T4171 7032-7042 NNS denotes phenotypes
T4172 7042-7044 , denotes ,
T4173 7044-7047 CC denotes and
T4174 7048-7051 DT denotes the
T4176 7052-7060 VBN denotes presumed
T4177 7061-7071 VBG denotes underlying
T4178 7072-7077 NN denotes TFIIH
T4175 7078-7086 NN denotes function
T4179 7087-7089 IN denotes in
T4180 7090-7094 NNS denotes mice
T4181 7095-7098 CC denotes and
T4182 7099-7104 NNS denotes cells
T4183 7105-7107 VBZ denotes is
T4162 7108-7117 VBN denotes presented
T4184 7118-7120 IN denotes in
T4185 7121-7126 NN denotes Table
T4186 7127-7128 CD denotes 2
T4187 7128-7129 . denotes .
R2083 T3312 T3313 amod Molecular,Mechanisms
R2084 T3314 T3313 prep of,Mechanisms
R2085 T3315 T3316 amod Biallelic,Effects
R2086 T3316 T3314 pobj Effects,of
R2087 T3318 T3319 nsubj We,turned
R2088 T3320 T3319 advmod next,turned
R2089 T3321 T3319 prep to,turned
R2090 T3322 T3323 npadvmod UV,based
R2091 T3323 T3325 amod based,assays
R2092 T3324 T3323 punct -,based
R2093 T3325 T3321 pobj assays,to
R2094 T3326 T3325 amod cellular,assays
R2095 T3327 T3325 prep including,assays
R2096 T3328 T3329 amod unscheduled,synthesis
R2097 T3329 T3327 pobj synthesis,including
R2098 T3330 T3329 compound DNA,synthesis
R2099 T3331 T3329 prep after,synthesis
R2100 T3332 T3333 compound UV,irradiation
R2101 T3333 T3331 pobj irradiation,after
R2102 T3334 T3335 punct (,UDS
R2103 T3335 T3329 parataxis UDS,synthesis
R2104 T3336 T3335 compound UV,UDS
R2105 T3337 T3335 punct -,UDS
R2106 T3338 T3335 punct ),UDS
R2107 T3339 T3329 punct ", ",synthesis
R2108 T3340 T3329 conj recovery,synthesis
R2109 T3341 T3340 prep of,recovery
R2110 T3342 T3343 compound RNA,synthesis
R2111 T3343 T3341 pobj synthesis,of
R2112 T3344 T3340 prep after,recovery
R2113 T3345 T3346 compound UV,irradiation
R2114 T3346 T3344 pobj irradiation,after
R2115 T3347 T3348 punct (,RRS
R2116 T3348 T3340 parataxis RRS,recovery
R2117 T3349 T3348 compound UV,RRS
R2118 T3350 T3348 punct -,RRS
R2119 T3351 T3348 punct ),RRS
R2120 T3352 T3340 punct ", ",recovery
R2121 T3353 T3340 cc and,recovery
R2122 T3354 T3355 compound UV,survival
R2123 T3355 T3340 conj survival,recovery
R2124 T3356 T3329 punct ", ",synthesis
R2125 T3357 T3358 dep which,report
R2126 T3358 T3329 relcl report,synthesis
R2127 T3359 T3358 prep on,report
R2128 T3360 T3361 det the,subpathways
R2129 T3361 T3359 pobj subpathways,on
R2130 T3362 T3361 compound NER,subpathways
R2131 T3363 T3364 punct (,NER
R2132 T3364 T3361 parataxis NER,subpathways
R2133 T3365 T3364 amod global,NER
R2134 T3366 T3364 compound genome,NER
R2135 T3367 T3364 cc and,NER
R2136 T3368 T3369 npadvmod transcription,coupled
R2137 T3369 T3371 amod coupled,NER
R2138 T3370 T3369 punct -,coupled
R2139 T3371 T3364 conj NER,NER
R2140 T3372 T3364 punct ),NER
R2141 T3373 T3361 cc and,subpathways
R2142 T3374 T3375 amod total,NER
R2143 T3375 T3361 conj NER,subpathways
R2144 T3376 T3358 punct ", ",report
R2145 T3377 T3358 advmod respectively,report
R2146 T3378 T3319 punct .,turned
R2147 T3380 T3381 prep In,improved
R2148 T3382 T3380 pobj none,In
R2149 T3383 T3382 prep of,none
R2150 T3384 T3385 det these,assays
R2151 T3385 T3383 pobj assays,of
R2152 T3386 T3381 auxpass was,improved
R2153 T3387 T3388 det the,response
R2154 T3388 T3381 nsubjpass response,improved
R2155 T3389 T3388 prep to,response
R2156 T3390 T3389 pobj UV,to
R2157 T3391 T3381 prep in,improved
R2158 T3392 T3393 compound compound,heterozygotes
R2159 T3393 T3391 pobj heterozygotes,in
R2160 T3394 T3381 advcl relative,improved
R2161 T3395 T3394 prep to,relative
R2162 T3396 T3397 compound TTD,homozygotes
R2163 T3397 T3395 pobj homozygotes,to
R2164 T3398 T3399 punct (,4A
R2165 T3399 T3381 parataxis 4A,improved
R2166 T3400 T3399 compound Figure,4A
R2167 T3401 T3402 punct –,4C
R2168 T3402 T3399 prep 4C,4A
R2169 T3403 T3399 punct ),4A
R2170 T3404 T3381 punct .,improved
R2171 T3406 T3407 advmod However,observed
R2172 T3408 T3407 punct ", ",observed
R2173 T3409 T3407 prep unlike,observed
R2174 T3410 T3411 det the,phenotypes
R2175 T3411 T3409 pobj phenotypes,unlike
R2176 T3412 T3413 advmod in,vivo
R2177 T3413 T3411 amod vivo,phenotypes
R2178 T3414 T3411 compound TTD,phenotypes
R2179 T3415 T3411 acl described,phenotypes
R2180 T3416 T3415 advmod above,described
R2181 T3417 T3411 punct ", ",phenotypes
R2182 T3418 T3419 prep in,were
R2183 T3419 T3411 relcl were,phenotypes
R2184 T3420 T3418 pobj which,in
R2185 T3421 T3422 nmod XpdTTD,TTD
R2186 T3422 T3424 nmod TTD,animals
R2187 T3423 T3422 punct /,TTD
R2188 T3424 T3419 nsubj animals,were
R2189 T3425 T3422 cc and,TTD
R2190 T3426 T3427 compound XpdTTD,KO
R2191 T3427 T3422 conj KO,TTD
R2192 T3428 T3427 punct /,KO
R2193 T3429 T3419 acomp indistinguishable,were
R2194 T3430 T3407 punct ", ",observed
R2195 T3431 T3432 compound XpdTTD,effects
R2196 T3432 T3407 nsubjpass effects,observed
R2197 T3433 T3432 compound dosage,effects
R2198 T3434 T3407 auxpass were,observed
R2199 T3435 T3407 prep in,observed
R2200 T3436 T3437 compound UV,survival
R2201 T3437 T3435 pobj survival,in
R2202 T3438 T3437 punct ", ",survival
R2203 T3439 T3440 compound UV,UDS
R2204 T3440 T3437 conj UDS,survival
R2205 T3441 T3440 punct -,UDS
R2206 T3442 T3440 punct ", ",UDS
R2207 T3443 T3440 cc and,UDS
R2208 T3444 T3445 compound UV,RRS
R2209 T3445 T3440 conj RRS,UDS
R2210 T3446 T3445 punct -,RRS
R2211 T3447 T3407 punct ", ",observed
R2212 T3448 T3407 advcl indicating,observed
R2213 T3449 T3450 mark that,correlate
R2214 T3450 T3448 ccomp correlate,indicating
R2215 T3451 T3452 amod cellular,parameters
R2216 T3452 T3450 nsubj parameters,correlate
R2217 T3453 T3454 mark as,measured
R2218 T3454 T3452 advcl measured,parameters
R2219 T3455 T3454 prep in,measured
R2220 T3456 T3455 pobj fibroblasts,in
R2221 T3457 T3454 advmod here,measured
R2222 T3458 T3450 aux do,correlate
R2223 T3459 T3450 neg not,correlate
R2224 T3460 T3450 advmod always,correlate
R2225 T3461 T3450 prep with,correlate
R2226 T3462 T3463 det the,phenotype
R2227 T3463 T3461 pobj phenotype,with
R2228 T3464 T3450 prep at,correlate
R2229 T3465 T3466 det the,level
R2230 T3466 T3464 pobj level,at
R2231 T3467 T3466 prep of,level
R2232 T3468 T3469 det the,organism
R2233 T3469 T3467 pobj organism,of
R2234 T3470 T3469 amod intact,organism
R2235 T3471 T3407 punct .,observed
R2236 T3473 T3474 nmod XpdTTD,KO
R2237 T3474 T3476 nmod KO,cells
R2238 T3475 T3474 punct /,KO
R2239 T3476 T3478 nsubjpass cells,used
R2240 T3477 T3476 amod hemizygous,cells
R2241 T3479 T3478 auxpass were,used
R2242 T3480 T3478 advmod thus,used
R2243 T3481 T3478 prep as,used
R2244 T3482 T3483 det the,baseline
R2245 T3483 T3481 pobj baseline,as
R2246 T3484 T3485 prep on,compare
R2247 T3485 T3483 relcl compare,baseline
R2248 T3486 T3484 pobj which,on
R2249 T3487 T3485 aux to,compare
R2250 T3488 T3489 det the,activity
R2251 T3489 T3485 dobj activity,compare
R2252 T3490 T3489 prep of,activity
R2253 T3491 T3492 nmod compound,cells
R2254 T3492 T3490 pobj cells,of
R2255 T3493 T3492 amod heterozygous,cells
R2256 T3494 T3478 punct .,used
R2257 T3496 T3497 advcl Relative,improved
R2258 T3498 T3496 prep to,Relative
R2259 T3499 T3500 compound XpdTTD,KO
R2260 T3500 T3502 compound KO,cells
R2261 T3501 T3500 punct /,KO
R2262 T3502 T3498 pobj cells,to
R2263 T3503 T3502 compound hemizygote,cells
R2264 T3504 T3497 punct ", ",improved
R2265 T3505 T3506 compound UV,survival
R2266 T3506 T3497 nsubjpass survival,improved
R2267 T3507 T3497 auxpass was,improved
R2268 T3508 T3497 prep by,improved
R2269 T3509 T3510 det the,allele
R2270 T3510 T3508 pobj allele,by
R2271 T3511 T3510 amod homozygous,allele
R2272 T3512 T3510 amod lethal,allele
R2273 T3513 T3510 compound Xpd†XPCS,allele
R2274 T3514 T3510 prep in,allele
R2275 T3515 T3516 nmod XpdTTD,†XPCS
R2276 T3516 T3518 nmod †XPCS,cells
R2277 T3517 T3516 punct /,†XPCS
R2278 T3518 T3514 pobj cells,in
R2279 T3519 T3518 nmod compound,cells
R2280 T3520 T3518 amod heterozygous,cells
R2281 T3521 T3508 cc and,by
R2282 T3522 T3523 prep to,by
R2283 T3523 T3508 conj by,by
R2284 T3524 T3525 det a,degree
R2285 T3525 T3522 pobj degree,to
R2286 T3526 T3525 amod lesser,degree
R2287 T3527 T3528 det the,allele
R2288 T3528 T3523 pobj allele,by
R2289 T3529 T3528 compound Xpd†XP,allele
R2290 T3530 T3531 punct (,4A
R2291 T3531 T3497 parataxis 4A,improved
R2292 T3532 T3531 compound Figure,4A
R2293 T3533 T3531 punct ),4A
R2294 T3534 T3497 punct .,improved
R2295 T3536 T3537 prep Because,were
R2296 T3538 T3536 pcomp of,Because
R2297 T3539 T3540 amod embryonic,lethality
R2298 T3540 T3536 pobj lethality,Because
R2299 T3541 T3539 cc and,embryonic
R2300 T3542 T3539 conj cellular,embryonic
R2301 T3543 T3537 punct ", ",were
R2302 T3544 T3537 nsubj we,were
R2303 T3545 T3537 acomp unable,were
R2304 T3546 T3547 aux to,test
R2305 T3547 T3545 xcomp test,unable
R2306 T3548 T3549 compound UV,survival
R2307 T3549 T3547 dobj survival,test
R2308 T3550 T3549 acl associated,survival
R2309 T3551 T3550 advmod exclusively,associated
R2310 T3552 T3550 prep with,associated
R2311 T3553 T3554 det the,alleles
R2312 T3554 T3552 pobj alleles,with
R2313 T3555 T3554 nmod Xpd†XPCS,alleles
R2314 T3556 T3555 cc or,Xpd†XPCS
R2315 T3557 T3555 conj Xpd†XP,Xpd†XPCS
R2316 T3558 T3537 punct .,were
R2317 T3560 T3561 advmod However,known
R2318 T3562 T3561 punct ", ",known
R2319 T3563 T3564 amod homozygous,XPDXP
R2320 T3564 T3565 nmod XPDXP,cells
R2321 T3565 T3561 nsubjpass cells,known
R2322 T3566 T3567 punct (,XPDR683W
R2323 T3567 T3564 parataxis XPDR683W,XPDXP
R2324 T3568 T3567 punct ),XPDR683W
R2325 T3569 T3564 cc and,XPDXP
R2326 T3570 T3571 amod hemizygous,XPDXPCS
R2327 T3571 T3564 conj XPDXPCS,XPDXP
R2328 T3572 T3573 punct (,XPDG602D
R2329 T3573 T3571 parataxis XPDG602D,XPDXPCS
R2330 T3574 T3573 punct ),XPDG602D
R2331 T3575 T3565 amod human,cells
R2332 T3576 T3561 auxpass are,known
R2333 T3577 T3578 aux to,be
R2334 T3578 T3561 xcomp be,known
R2335 T3579 T3580 advmod highly,sensitive
R2336 T3580 T3578 acomp sensitive,be
R2337 T3581 T3580 prep to,sensitive
R2338 T3582 T3581 pobj UV,to
R2339 T3583 T3584 punct [,25
R2340 T3584 T3578 parataxis 25,be
R2341 T3585 T3584 nummod 19,25
R2342 T3586 T3584 punct ",",25
R2343 T3587 T3584 punct ],25
R2344 T3588 T3561 punct ", ",known
R2345 T3589 T3590 mark as,are
R2346 T3590 T3561 advcl are,known
R2347 T3591 T3590 nsubj cells,are
R2348 T3592 T3591 prep from,cells
R2349 T3593 T3594 det a,model
R2350 T3594 T3592 pobj model,from
R2351 T3595 T3594 amod homozygous,model
R2352 T3596 T3594 amod viable,model
R2353 T3597 T3598 nmod XpdXPCS,XPCS
R2354 T3598 T3594 nmod XPCS,model
R2355 T3599 T3598 punct /,XPCS
R2356 T3600 T3601 punct (,G602D
R2357 T3601 T3598 parataxis G602D,XPCS
R2358 T3602 T3601 compound XPDG602D,G602D
R2359 T3603 T3601 punct /,G602D
R2360 T3604 T3601 punct ),G602D
R2361 T3605 T3594 compound mouse,model
R2362 T3606 T3607 punct (,4A
R2363 T3607 T3590 parataxis 4A,are
R2364 T3608 T3607 compound Figure,4A
R2365 T3609 T3607 punct ", ",4A
R2366 T3610 T3611 amod dotted,line
R2367 T3611 T3607 appos line,4A
R2368 T3612 T3607 punct ),4A
R2369 T3613 T3614 punct [,23
R2370 T3614 T3561 parataxis 23,known
R2371 T3615 T3614 punct ],23
R2372 T3616 T3561 punct .,known
R2373 T3618 T3619 advmod Thus,represents
R2374 T3620 T3619 punct ", ",represents
R2375 T3621 T3622 det the,survival
R2376 T3622 T3619 nsubj survival,represents
R2377 T3623 T3622 prep of,survival
R2378 T3624 T3625 nmod XpdTTD,†XPCS
R2379 T3625 T3627 nmod †XPCS,cells
R2380 T3626 T3625 punct /,†XPCS
R2381 T3627 T3623 pobj cells,of
R2382 T3628 T3625 punct (,†XPCS
R2383 T3629 T3625 cc and,†XPCS
R2384 T3630 T3631 compound XpdTTD,†XP
R2385 T3631 T3625 conj †XP,†XPCS
R2386 T3632 T3631 punct /,†XP
R2387 T3633 T3627 punct ),cells
R2388 T3634 T3619 advmod likely,represents
R2389 T3635 T3636 det a,level
R2390 T3636 T3619 dobj level,represents
R2391 T3637 T3636 prep of,level
R2392 T3638 T3639 compound UV,resistance
R2393 T3639 T3637 pobj resistance,of
R2394 T3640 T3641 dep that,impart
R2395 T3641 T3636 relcl impart,level
R2396 T3642 T3643 preconj neither,allele
R2397 T3643 T3641 nsubj allele,impart
R2398 T3644 T3643 amod mutant,allele
R2399 T3645 T3641 aux can,impart
R2400 T3646 T3641 prep on,impart
R2401 T3647 T3648 poss its,own
R2402 T3648 T3646 pobj own,on
R2403 T3649 T3650 punct (,Table
R2404 T3650 T3619 parataxis Table,represents
R2405 T3651 T3650 nummod 2,Table
R2406 T3652 T3650 punct ),Table
R2407 T3653 T3619 punct .,represents
R2408 T3655 T3656 amod Significant,effects
R2409 T3656 T3657 nsubjpass effects,observed
R2410 T3658 T3656 prep of,effects
R2411 T3659 T3660 compound compound,heterozygosity
R2412 T3660 T3658 pobj heterozygosity,of
R2413 T3661 T3656 prep on,effects
R2414 T3662 T3663 compound NER,subpathways
R2415 T3663 T3661 pobj subpathways,on
R2416 T3664 T3656 amod relative,effects
R2417 T3665 T3664 prep to,relative
R2418 T3666 T3667 compound XpdTTD,KO
R2419 T3667 T3669 compound KO,cells
R2420 T3668 T3667 punct /,KO
R2421 T3669 T3665 pobj cells,to
R2422 T3670 T3657 auxpass were,observed
R2423 T3671 T3657 prep in,observed
R2424 T3672 T3673 compound XpdTTD,†XP
R2425 T3673 T3675 compound †XP,cells
R2426 T3674 T3673 punct /,†XP
R2427 T3675 T3671 pobj cells,in
R2428 T3676 T3671 cc but,in
R2429 T3677 T3678 advmod only,for
R2430 T3678 T3671 conj for,in
R2431 T3679 T3680 compound UV,UDS
R2432 T3680 T3682 compound UDS,activity
R2433 T3681 T3680 punct -,UDS
R2434 T3682 T3678 pobj activity,for
R2435 T3683 T3657 punct .,observed
R2436 T3685 T3686 advmod Finally,exhibited
R2437 T3687 T3686 punct ", ",exhibited
R2438 T3688 T3686 nsubj none,exhibited
R2439 T3689 T3688 prep of,none
R2440 T3690 T3691 det the,combinations
R2441 T3691 T3689 pobj combinations,of
R2442 T3692 T3691 amod mutant,combinations
R2443 T3693 T3691 compound TFIIH,combinations
R2444 T3694 T3691 punct (,combinations
R2445 T3695 T3691 acl carrying,combinations
R2446 T3696 T3695 dobj alterations,carrying
R2447 T3697 T3696 acl associated,alterations
R2448 T3698 T3697 prep with,associated
R2449 T3699 T3698 pobj TTD,with
R2450 T3700 T3701 punct [,XPDR722W
R2451 T3701 T3699 parataxis XPDR722W,TTD
R2452 T3702 T3701 punct ],XPDR722W
R2453 T3703 T3699 punct ", ",TTD
R2454 T3704 T3699 conj XPCS,TTD
R2455 T3705 T3706 punct [,XPDG602D
R2456 T3706 T3704 parataxis XPDG602D,XPCS
R2457 T3707 T3706 punct ],XPDG602D
R2458 T3708 T3704 punct ", ",XPCS
R2459 T3709 T3704 cc or,XPCS
R2460 T3710 T3704 conj XP,XPCS
R2461 T3711 T3712 punct [,XPDR683W
R2462 T3712 T3710 parataxis XPDR683W,XP
R2463 T3713 T3712 punct ],XPDR683W
R2464 T3714 T3686 punct ),exhibited
R2465 T3715 T3686 dobj synergism,exhibited
R2466 T3716 T3686 prep in,exhibited
R2467 T3717 T3718 det an,reaction
R2468 T3718 T3716 pobj reaction,in
R2469 T3719 T3720 advmod in,vitro
R2470 T3720 T3718 amod vitro,reaction
R2471 T3721 T3718 compound NER,reaction
R2472 T3722 T3718 acl reconstituted,reaction
R2473 T3723 T3722 prep with,reconstituted
R2474 T3724 T3725 amod different,complexes
R2475 T3725 T3723 pobj complexes,with
R2476 T3726 T3725 amod mutant,complexes
R2477 T3727 T3725 compound TFIIH,complexes
R2478 T3728 T3729 punct (,4D
R2479 T3729 T3686 parataxis 4D,exhibited
R2480 T3730 T3729 compound Figure,4D
R2481 T3731 T3729 punct ),4D
R2482 T3732 T3686 punct .,exhibited
R2483 T3734 T3735 advcl Taken,are
R2484 T3736 T3734 advmod together,Taken
R2485 T3737 T3735 punct ", ",are
R2486 T3738 T3739 det these,data
R2487 T3739 T3735 nsubj data,are
R2488 T3740 T3735 acomp consistent,are
R2489 T3741 T3740 prep with,consistent
R2490 T3742 T3743 amod interallelic,complementation
R2491 T3743 T3741 pobj complementation,with
R2492 T3744 T3743 prep of,complementation
R2493 T3745 T3746 compound UV,sensitivity
R2494 T3746 T3744 pobj sensitivity,of
R2495 T3747 T3743 prep in,complementation
R2496 T3748 T3747 pobj cells,in
R2497 T3749 T3735 cc but,are
R2498 T3750 T3735 conj underscore,are
R2499 T3751 T3752 det the,lack
R2500 T3752 T3750 dobj lack,underscore
R2501 T3753 T3752 prep of,lack
R2502 T3754 T3755 det any,correlation
R2503 T3755 T3753 pobj correlation,of
R2504 T3756 T3755 prep between,correlation
R2505 T3757 T3758 npadvmod UV,related
R2506 T3758 T3760 amod related,characteristics
R2507 T3759 T3758 punct -,related
R2508 T3760 T3756 pobj characteristics,between
R2509 T3761 T3760 compound repair,characteristics
R2510 T3762 T3760 cc and,characteristics
R2511 T3763 T3764 compound TTD,phenotypes
R2512 T3764 T3760 conj phenotypes,characteristics
R2513 T3765 T3764 compound progeroid,phenotypes
R2514 T3766 T3755 prep in,correlation
R2515 T3767 T3768 compound animal,models
R2516 T3768 T3766 pobj models,in
R2517 T3769 T3735 punct .,are
R2518 T3778 T3779 nsubj sk,e
R2519 T3779 T3780 ccomp e,t
R2520 T3781 T3779 dobj d,e
R2521 T3782 T3781 prep wh,d
R2522 T3783 T3780 nsubj e,t
R2523 T3789 T3790 det h,e
R2524 T3798 T3797 cc and,†XPCS
R2525 T3799 T3800 compound Xpd,†XP
R2526 T3800 T3797 conj †XP,†XPCS
R2527 T3801 T3802 amod a,l
R2528 T3804 T3805 nsubj l,e
R2529 T3806 T3805 dobj les,e
R2530 T3812 T3811 pobj e,it
R2531 T3817 T3818 amod re,a
R2532 T3821 T3820 cc d,e
R2533 T3822 T3820 conj m,e
R2534 T3826 T3825 compound RNA,levels
R2535 T3827 T3824 punct ", ",ameliorated
R2536 T3828 T3829 compound TTD,symptoms
R2537 T3829 T3824 dobj symptoms,ameliorated
R2538 T3830 T3824 prep by,ameliorated
R2539 T3831 T3832 amod increasing,levels
R2540 T3832 T3830 pobj levels,by
R2541 T3833 T3832 amod overall,levels
R2542 T3834 T3832 compound TFIIH,levels
R2543 T3835 T3824 prep in,ameliorated
R2544 T3836 T3837 nmod compound,cells
R2545 T3837 T3835 pobj cells,in
R2546 T3838 T3837 amod heterozygous,cells
R2547 T3839 T3840 nmod XpdTTD, †XPCS
R2548 T3840 T3837 nmod  †XPCS,cells
R2549 T3841 T3840 punct /, †XPCS
R2550 T3842 T3840 cc and, †XPCS
R2551 T3843 T3844 compound XpdTTD, †XP
R2552 T3844 T3840 conj  †XP, †XPCS
R2553 T3845 T3844 punct /, †XP
R2554 T3848 T3849 advmod Previously,shown
R2555 T3850 T3849 punct ", ",shown
R2556 T3851 T3849 advcl using,shown
R2557 T3852 T3853 amod comparative,immunohistochemistry
R2558 T3853 T3851 dobj immunohistochemistry,using
R2559 T3854 T3849 punct ", ",shown
R2560 T3855 T3849 nsubj we,shown
R2561 T3856 T3855 cc and,we
R2562 T3857 T3855 conj others,we
R2563 T3858 T3849 aux have,shown
R2564 T3859 T3860 det an,reduction
R2565 T3860 T3849 dobj reduction,shown
R2566 T3861 T3862 quantmod up,70
R2567 T3862 T3864 nummod 70,%
R2568 T3863 T3862 quantmod to,70
R2569 T3864 T3860 compound %,reduction
R2570 T3865 T3860 prep of,reduction
R2571 T3866 T3867 compound TFIIH,levels
R2572 T3867 T3865 pobj levels,of
R2573 T3868 T3867 prep in,levels
R2574 T3869 T3870 amod primary,fibroblasts
R2575 T3870 T3868 pobj fibroblasts,in
R2576 T3871 T3870 prep from,fibroblasts
R2577 T3872 T3871 pobj patients,from
R2578 T3873 T3872 prep with,patients
R2579 T3874 T3873 pobj TTD,with
R2580 T3875 T3860 prep compared,reduction
R2581 T3876 T3875 prep with,compared
R2582 T3877 T3878 compound wt,controls
R2583 T3878 T3876 pobj controls,with
R2584 T3879 T3860 prep due,reduction
R2585 T3880 T3879 pcomp to,due
R2586 T3881 T3882 amod reduced,stability
R2587 T3882 T3879 pobj stability,due
R2588 T3883 T3884 punct [,17
R2589 T3884 T3849 parataxis 17,shown
R2590 T3885 T3884 nummod 16,17
R2591 T3886 T3884 punct ",",17
R2592 T3887 T3884 punct ],17
R2593 T3888 T3849 punct .,shown
R2594 T3890 T3891 prep Despite,reduced
R2595 T3892 T3890 pobj overexpression,Despite
R2596 T3893 T3892 prep of,overexpression
R2597 T3894 T3893 pobj mRNA,of
R2598 T3895 T3894 prep from,mRNA
R2599 T3896 T3897 det the,allele
R2600 T3897 T3895 pobj allele,from
R2601 T3898 T3897 compound XpdTTD,allele
R2602 T3899 T3892 amod relative,overexpression
R2603 T3900 T3899 prep to,relative
R2604 T3901 T3902 det the,allele
R2605 T3902 T3900 pobj allele,to
R2606 T3903 T3902 compound wt,allele
R2607 T3904 T3905 punct (,1E
R2608 T3905 T3892 parataxis 1E,overexpression
R2609 T3906 T3905 compound Figure,1E
R2610 T3907 T3905 punct ),1E
R2611 T3908 T3891 punct ", ",reduced
R2612 T3909 T3910 compound TFIIH,levels
R2613 T3910 T3891 nsubjpass levels,reduced
R2614 T3911 T3910 compound protein,levels
R2615 T3912 T3891 auxpass were,reduced
R2616 T3913 T3891 prep by,reduced
R2617 T3914 T3915 nummod 50,%
R2618 T3915 T3913 pobj %,by
R2619 T3916 T3891 prep in,reduced
R2620 T3917 T3918 amod primary,fibroblasts
R2621 T3918 T3916 pobj fibroblasts,in
R2622 T3919 T3918 compound mouse,fibroblasts
R2623 T3920 T3921 compound XpdTTD,TTD
R2624 T3921 T3918 compound TTD,fibroblasts
R2625 T3922 T3921 punct /,TTD
R2626 T3923 T3924 punct (,4E
R2627 T3924 T3891 parataxis 4E,reduced
R2628 T3925 T3924 compound Figure,4E
R2629 T3926 T3924 cc and,4E
R2630 T3927 T3924 conj 4F,4E
R2631 T3928 T3924 punct ),4E
R2632 T3929 T3891 punct ", ",reduced
R2633 T3930 T3931 advmod thereby,mimicking
R2634 T3931 T3891 advcl mimicking,reduced
R2635 T3932 T3933 det the,situation
R2636 T3933 T3931 dobj situation,mimicking
R2637 T3934 T3931 prep in,mimicking
R2638 T3935 T3936 amod human,patients
R2639 T3936 T3934 pobj patients,in
R2640 T3937 T3936 prep with,patients
R2641 T3938 T3937 pobj TTD,with
R2642 T3939 T3891 punct .,reduced
R2643 T3941 T3942 prep In,observed
R2644 T3943 T3941 pobj accordance,In
R2645 T3944 T3943 prep with,accordance
R2646 T3945 T3946 det the,dosage
R2647 T3946 T3944 pobj dosage,with
R2648 T3947 T3946 compound gene,dosage
R2649 T3948 T3942 punct ", ",observed
R2650 T3949 T3950 det a,reduction
R2651 T3950 T3942 nsubjpass reduction,observed
R2652 T3951 T3950 amod further,reduction
R2653 T3952 T3950 prep of,reduction
R2654 T3953 T3954 quantmod up,70
R2655 T3954 T3956 nummod 70,%
R2656 T3955 T3954 quantmod to,70
R2657 T3956 T3952 pobj %,of
R2658 T3957 T3956 prep of,%
R2659 T3958 T3959 det the,level
R2660 T3959 T3957 pobj level,of
R2661 T3960 T3959 compound wt,level
R2662 T3961 T3942 auxpass was,observed
R2663 T3962 T3942 prep in,observed
R2664 T3963 T3964 amod hemizygous,cells
R2665 T3964 T3962 pobj cells,in
R2666 T3965 T3966 compound XpdTTD,KO
R2667 T3966 T3964 compound KO,cells
R2668 T3967 T3966 punct /,KO
R2669 T3968 T3942 punct .,observed
R2670 T3970 T3971 advcl Consistent,was
R2671 T3972 T3970 prep with,Consistent
R2672 T3973 T3974 amod low,levels
R2673 T3974 T3972 pobj levels,with
R2674 T3975 T3976 compound mRNA,expression
R2675 T3976 T3974 compound expression,levels
R2676 T3977 T3971 punct ", ",was
R2677 T3978 T3979 preconj neither,allele
R2678 T3979 T3971 nsubj allele,was
R2679 T3980 T3981 det the,Xpd†XPCS
R2680 T3981 T3979 nmod Xpd†XPCS,allele
R2681 T3982 T3981 cc nor,Xpd†XPCS
R2682 T3983 T3984 det the,Xpd†XP
R2683 T3984 T3981 conj Xpd†XP,Xpd†XPCS
R2684 T3985 T3971 acomp able,was
R2685 T3986 T3987 aux to,restore
R2686 T3987 T3985 xcomp restore,able
R2687 T3988 T3989 compound TFIIH,abundance
R2688 T3989 T3987 dobj abundance,restore
R2689 T3990 T3987 prep to,restore
R2690 T3991 T3992 compound wt,levels
R2691 T3992 T3990 pobj levels,to
R2692 T3993 T3987 prep in,restore
R2693 T3994 T3995 compound XpdTTD,cells
R2694 T3995 T3993 pobj cells,in
R2695 T3996 T3995 compound compound,cells
R2696 T3997 T3995 compound heterozygote,cells
R2697 T3998 T3999 punct (,4E
R2698 T3999 T3971 parataxis 4E,was
R2699 T4000 T3999 compound Figure,4E
R2700 T4001 T3999 cc and,4E
R2701 T4002 T3999 conj 4F,4E
R2702 T4003 T3999 punct ),4E
R2703 T4004 T3971 punct .,was
R2704 T4006 T4007 advmod Thus,were
R2705 T4008 T4007 punct ", ",were
R2706 T4009 T4010 det the,survival
R2707 T4010 T4007 nsubj survival,were
R2708 T4011 T4010 amod improved,survival
R2709 T4012 T4010 compound UV,survival
R2710 T4013 T4010 acl observed,survival
R2711 T4014 T4013 prep in,observed
R2712 T4015 T4016 compound compound,cells
R2713 T4016 T4014 pobj cells,in
R2714 T4017 T4016 compound heterozygote,cells
R2715 T4018 T4019 punct (,4A
R2716 T4019 T4013 parataxis 4A,observed
R2717 T4020 T4019 compound Figure,4A
R2718 T4021 T4019 punct ),4A
R2719 T4022 T4013 cc and,observed
R2720 T4023 T4024 advmod likely,rescue
R2721 T4024 T4013 conj rescue,observed
R2722 T4025 T4024 det the,rescue
R2723 T4026 T4024 prep of,rescue
R2724 T4027 T4028 compound TTD,symptoms
R2725 T4028 T4026 pobj symptoms,of
R2726 T4029 T4028 compound progeroid,symptoms
R2727 T4030 T4031 punct (,Figure
R2728 T4031 T4024 parataxis Figure,rescue
R2729 T4032 T4031 nummod 3,Figure
R2730 T4033 T4031 punct ),Figure
R2731 T4034 T4007 neg not,were
R2732 T4035 T4007 prep due,were
R2733 T4036 T4035 pcomp to,due
R2734 T4037 T4035 pobj normalisation,due
R2735 T4038 T4037 prep of,normalisation
R2736 T4039 T4040 compound TFIIH,levels
R2737 T4040 T4038 pobj levels,of
R2738 T4041 T4007 punct ", ",were
R2739 T4042 T4007 advcl suggesting,were
R2740 T4043 T4044 advmod a,qualitative
R2741 T4044 T4045 amod qualitative,effect
R2742 T4045 T4042 dobj effect,suggesting
R2743 T4046 T4047 advmod rather,than
R2744 T4047 T4044 cc than,qualitative
R2745 T4048 T4049 advmod a,quantitative
R2746 T4049 T4044 conj quantitative,qualitative
R2747 T4050 T4045 prep on,effect
R2748 T4051 T4052 det these,phenotypes
R2749 T4052 T4050 pobj phenotypes,on
R2750 T4053 T4054 advmod in,vivo
R2751 T4054 T4045 advmod vivo,effect
R2752 T4055 T4007 punct .,were
R2753 T4057 T4058 prep In,affect
R2754 T4059 T4057 pobj contrast,In
R2755 T4060 T4058 punct ", ",affect
R2756 T4061 T4062 det the,level
R2757 T4062 T4058 nsubj level,affect
R2758 T4063 T4062 prep of,level
R2759 T4064 T4065 compound XPCS,expression
R2760 T4065 T4063 pobj expression,of
R2761 T4066 T4065 compound mRNA,expression
R2762 T4067 T4058 aux did,affect
R2763 T4068 T4069 det the,ability
R2764 T4069 T4058 dobj ability,affect
R2765 T4070 T4069 prep of,ability
R2766 T4071 T4072 det the,protein
R2767 T4072 T4070 pobj protein,of
R2768 T4073 T4072 amod encoded,protein
R2769 T4074 T4072 punct (,protein
R2770 T4075 T4072 appos XPDG602D,protein
R2771 T4076 T4069 punct ),ability
R2772 T4077 T4078 aux to,restore
R2773 T4078 T4069 acl restore,ability
R2774 T4079 T4080 det the,phenotype
R2775 T4080 T4078 dobj phenotype,restore
R2776 T4081 T4080 compound TTD,phenotype
R2777 T4082 T4080 compound hair,phenotype
R2778 T4083 T4078 prep to,restore
R2779 T4084 T4083 amod normal,to
R2780 T4085 T4058 punct .,affect
R2781 T4087 T4088 advmod Notably,had
R2782 T4089 T4088 punct ", ",had
R2783 T4090 T4091 compound XpdTTD, †XPCS
R2784 T4091 T4093 compound  †XPCS,animals
R2785 T4092 T4091 punct /, †XPCS
R2786 T4093 T4088 nsubj animals,had
R2787 T4094 T4095 det a,phenotype
R2788 T4095 T4088 dobj phenotype,had
R2789 T4096 T4095 amod partial,phenotype
R2790 T4097 T4095 compound TTD,phenotype
R2791 T4098 T4095 compound hair,phenotype
R2792 T4099 T4095 punct ", ",phenotype
R2793 T4100 T4095 acl correlating,phenotype
R2794 T4101 T4100 prep with,correlating
R2795 T4102 T4103 amod low,levels
R2796 T4103 T4101 pobj levels,with
R2797 T4104 T4103 prep of,levels
R2798 T4105 T4106 compound Xpd†XPCS,expression
R2799 T4106 T4104 pobj expression,of
R2800 T4107 T4088 punct ", ",had
R2801 T4108 T4109 mark whereas,had
R2802 T4109 T4088 advcl had,had
R2803 T4110 T4111 compound XpdTTD,XPCS
R2804 T4111 T4113 compound XPCS,animals
R2805 T4112 T4111 punct /,XPCS
R2806 T4113 T4109 nsubj animals,had
R2807 T4114 T4115 compound wt,hair
R2808 T4115 T4109 dobj hair,had
R2809 T4116 T4115 punct ", ",hair
R2810 T4117 T4115 acl correlating,hair
R2811 T4118 T4117 prep with,correlating
R2812 T4119 T4120 amod normal,levels
R2813 T4120 T4118 pobj levels,with
R2814 T4121 T4120 compound expression,levels
R2815 T4122 T4120 prep from,levels
R2816 T4123 T4124 det the,allele
R2817 T4124 T4122 pobj allele,from
R2818 T4125 T4124 amod viable,allele
R2819 T4126 T4124 compound XpdXPCS,allele
R2820 T4127 T4128 punct (,Table
R2821 T4128 T4088 parataxis Table,had
R2822 T4129 T4128 nummod 2,Table
R2823 T4130 T4128 cc and,Table
R2824 T4131 T4132 amod unpublished,data
R2825 T4132 T4128 conj data,Table
R2826 T4133 T4128 punct ),Table
R2827 T4134 T4088 punct .,had
R2828 T4136 T4137 advmod Thus,affected
R2829 T4138 T4137 punct ", ",affected
R2830 T4139 T4140 det the,range
R2831 T4140 T4137 nsubj range,affected
R2832 T4141 T4140 prep of,range
R2833 T4142 T4143 compound expression,levels
R2834 T4143 T4141 pobj levels,of
R2835 T4144 T4140 prep from,range
R2836 T4145 T4146 det these,alleles
R2837 T4146 T4144 pobj alleles,from
R2838 T4147 T4146 nummod two,alleles
R2839 T4148 T4146 amod mutant,alleles
R2840 T4149 T4150 poss their,ability
R2841 T4150 T4137 dobj ability,affected
R2842 T4151 T4152 aux to,complement
R2843 T4152 T4150 acl complement,ability
R2844 T4153 T4154 det some,phenotypes
R2845 T4154 T4152 dobj phenotypes,complement
R2846 T4155 T4156 punct (,hair
R2847 T4156 T4154 parataxis hair,phenotypes
R2848 T4157 T4156 punct ),hair
R2849 T4158 T4137 punct .,affected
R2850 T4160 T4161 det An,overview
R2851 T4161 T4162 nsubjpass overview,presented
R2852 T4163 T4161 prep of,overview
R2853 T4164 T4165 det the,relationships
R2854 T4165 T4163 pobj relationships,of
R2855 T4166 T4165 amod functional,relationships
R2856 T4167 T4165 prep between,relationships
R2857 T4168 T4169 compound Xpd,alleles
R2858 T4169 T4167 pobj alleles,between
R2859 T4170 T4169 punct ", ",alleles
R2860 T4171 T4169 conj phenotypes,alleles
R2861 T4172 T4171 punct ", ",phenotypes
R2862 T4173 T4171 cc and,phenotypes
R2863 T4174 T4175 det the,function
R2864 T4175 T4171 conj function,phenotypes
R2865 T4176 T4175 amod presumed,function
R2866 T4177 T4175 amod underlying,function
R2867 T4178 T4175 compound TFIIH,function
R2868 T4179 T4165 prep in,relationships
R2869 T4180 T4179 pobj mice,in
R2870 T4181 T4180 cc and,mice
R2871 T4182 T4180 conj cells,mice
R2872 T4183 T4162 auxpass is,presented
R2873 T4184 T4162 prep in,presented
R2874 T4185 T4184 pobj Table,in
R2875 T4186 T4185 nummod 2,Table
R2876 T4187 T4162 punct .,presented
R5707 T8564 T8565 compound TFIIH,Functions
R5708 T8566 T8565 cc and,Functions
R5709 T8567 T8565 conj Mechanisms,Functions
R5710 T8568 T8567 prep of,Mechanisms
R5711 T8569 T8570 npadvmod XPD,Associated
R5712 T8570 T8572 amod Associated,Pleiotropy
R5713 T8571 T8570 punct -,Associated
R5714 T8572 T8568 pobj Pleiotropy,of
R5715 T8573 T8572 compound Disease,Pleiotropy
R5716 T8575 T8576 punct (,A
R5717 T8576 T8577 meta A,survival
R5718 T8578 T8576 punct ),A
R5719 T8579 T8577 amod Cellular,survival
R5720 T8580 T8577 prep after,survival
R5721 T8581 T8582 compound UV,irradiation
R5722 T8582 T8580 pobj irradiation,after
R5723 T8583 T8577 punct .,survival
R5724 T8585 T8586 nsubjpass Rescue,illustrated
R5725 T8587 T8585 prep of,Rescue
R5726 T8588 T8589 amod hemizygous,survival
R5727 T8589 T8587 pobj survival,of
R5728 T8590 T8591 compound XpdTTD,KO
R5729 T8591 T8589 compound KO,survival
R5730 T8592 T8591 punct /,KO
R5731 T8593 T8585 prep by,Rescue
R5732 T8594 T8595 nmod Xpd†XPCS,alleles
R5733 T8595 T8593 pobj alleles,by
R5734 T8596 T8594 cc and,Xpd†XPCS
R5735 T8597 T8594 conj Xpd†XP,Xpd†XPCS
R5736 T8598 T8586 auxpass is,illustrated
R5737 T8599 T8586 agent by,illustrated
R5738 T8600 T8599 pobj arrows,by
R5739 T8601 T8600 acl marked,arrows
R5740 T8602 T8601 oprd A,marked
R5741 T8603 T8602 cc and,A
R5742 T8604 T8602 conj B,A
R5743 T8605 T8601 punct ", ",marked
R5744 T8606 T8601 advmod respectively,marked
R5745 T8607 T8586 punct .,illustrated
R5746 T8609 T8610 compound UV,survival
R5747 T8610 T8611 nsubjpass survival,depicted
R5748 T8612 T8610 prep of,survival
R5749 T8613 T8614 amod homozygous,cells
R5750 T8614 T8612 pobj cells,of
R5751 T8615 T8616 compound XpdXPCS,XPCS
R5752 T8616 T8614 compound XPCS,cells
R5753 T8617 T8616 punct /,XPCS
R5754 T8618 T8619 punct (,asterisk
R5755 T8619 T8614 parataxis asterisk,cells
R5756 T8620 T8619 punct ),asterisk
R5757 T8621 T8614 prep from,cells
R5758 T8622 T8623 det the,allele
R5759 T8623 T8621 pobj allele,from
R5760 T8624 T8625 advmod normally,expressed
R5761 T8625 T8623 amod expressed,allele
R5762 T8626 T8623 amod viable,allele
R5763 T8627 T8628 punct (,XpdXPCS
R5764 T8628 T8623 parataxis XpdXPCS,allele
R5765 T8629 T8628 punct ),XpdXPCS
R5766 T8630 T8611 auxpass is,depicted
R5767 T8631 T8611 prep by,depicted
R5768 T8632 T8633 det a,line
R5769 T8633 T8631 pobj line,by
R5770 T8634 T8633 amod dotted,line
R5771 T8635 T8611 punct .,depicted
R5772 T8637 T8638 compound Survival,curves
R5773 T8638 T8639 nsubj curves,represent
R5774 T8639 T8640 ccomp represent,included
R5775 T8641 T8642 det an,average
R5776 T8642 T8639 dobj average,represent
R5777 T8643 T8642 prep of,average
R5778 T8644 T8645 nummod four,experiments
R5779 T8645 T8643 pobj experiments,of
R5780 T8646 T8645 amod independent,experiments
R5781 T8647 T8640 punct ;,included
R5782 T8648 T8649 quantmod 1,2
R5783 T8649 T8651 nummod 2,lines
R5784 T8650 T8649 punct –,2
R5785 T8651 T8640 nsubjpass lines,included
R5786 T8652 T8651 compound cell,lines
R5787 T8653 T8651 prep per,lines
R5788 T8654 T8653 pobj genotype,per
R5789 T8655 T8640 auxpass were,included
R5790 T8656 T8640 prep in,included
R5791 T8657 T8658 det each,experiment
R5792 T8658 T8656 pobj experiment,in
R5793 T8659 T8640 punct .,included
R5794 T8661 T8662 compound Error,bars
R5795 T8662 T8663 nsubj bars,indicate
R5796 T8664 T8663 dobj SEM,indicate
R5797 T8665 T8664 prep between,SEM
R5798 T8666 T8665 pobj experiments,between
R5799 T8667 T8663 punct .,indicate
R5800 T8669 T8670 punct (,B
R5801 T8670 T8671 meta B,UDS
R5802 T8672 T8670 punct ),B
R5803 T8673 T8671 compound UV,UDS
R5804 T8674 T8671 punct -,UDS
R5805 T8675 T8671 punct ", ",UDS
R5806 T8676 T8677 det a,measure
R5807 T8677 T8671 appos measure,UDS
R5808 T8678 T8677 prep of,measure
R5809 T8679 T8680 amod global,repair
R5810 T8680 T8678 pobj repair,of
R5811 T8681 T8680 compound genome,repair
R5812 T8682 T8671 punct .,UDS
R5813 T8684 T8685 dep Number,included
R5814 T8686 T8684 prep of,Number
R5815 T8687 T8686 pobj experiments,of
R5816 T8688 T8685 punct : ,included
R5817 T8689 T8690 nsubj n,15
R5818 T8690 T8685 ccomp 15,included
R5819 T8691 T8690 punct =,15
R5820 T8692 T8693 punct (,XpdTTD
R5821 T8693 T8690 parataxis XpdTTD,15
R5822 T8694 T8693 punct /,XpdTTD
R5823 T8695 T8693 dep TTD,XpdTTD
R5824 T8696 T8693 punct ),XpdTTD
R5825 T8697 T8685 punct ", ",included
R5826 T8698 T8699 nsubj n,6
R5827 T8699 T8685 ccomp 6,included
R5828 T8700 T8699 punct =,6
R5829 T8701 T8702 punct (,KO
R5830 T8702 T8699 parataxis KO,6
R5831 T8703 T8702 compound XpdTTD,KO
R5832 T8704 T8702 punct /,KO
R5833 T8705 T8702 punct ),KO
R5834 T8706 T8685 punct ", ",included
R5835 T8707 T8708 nsubj n,4
R5836 T8708 T8685 ccomp 4,included
R5837 T8709 T8708 punct =,4
R5838 T8710 T8711 punct (,†XPCS
R5839 T8711 T8708 parataxis †XPCS,4
R5840 T8712 T8711 compound XpdTTD,†XPCS
R5841 T8713 T8711 punct /,†XPCS
R5842 T8714 T8711 punct ),†XPCS
R5843 T8715 T8685 punct ", ",included
R5844 T8716 T8717 nsubj n,2
R5845 T8717 T8685 ccomp 2,included
R5846 T8718 T8717 punct =,2
R5847 T8719 T8720 punct (,†XP
R5848 T8720 T8717 parataxis †XP,2
R5849 T8721 T8720 compound XpdTTD,†XP
R5850 T8722 T8720 punct /,†XP
R5851 T8723 T8720 punct ),†XP
R5852 T8724 T8685 punct ;,included
R5853 T8725 T8726 quantmod 1,2
R5854 T8726 T8728 nummod 2,lines
R5855 T8727 T8726 punct –,2
R5856 T8728 T8685 nsubjpass lines,included
R5857 T8729 T8728 compound cell,lines
R5858 T8730 T8728 prep per,lines
R5859 T8731 T8730 pobj genotype,per
R5860 T8732 T8685 auxpass were,included
R5861 T8733 T8685 prep in,included
R5862 T8734 T8735 det each,experiment
R5863 T8735 T8733 pobj experiment,in
R5864 T8736 T8685 punct .,included
R5865 T8738 T8739 det The,asterisk
R5866 T8739 T8740 nsubj asterisk,indicates
R5867 T8740 T8741 ccomp indicates,indicate
R5868 T8742 T8743 amod significant,difference
R5869 T8743 T8740 dobj difference,indicates
R5870 T8744 T8743 prep with,difference
R5871 T8745 T8746 compound XpdTTD,TTD
R5872 T8746 T8744 pobj TTD,with
R5873 T8747 T8746 punct /,TTD
R5874 T8748 T8741 punct ;,indicate
R5875 T8749 T8741 nsubj crosses,indicate
R5876 T8750 T8751 amod significant,differences
R5877 T8751 T8741 dobj differences,indicate
R5878 T8752 T8751 prep with,differences
R5879 T8753 T8754 compound XpdTTD,KO
R5880 T8754 T8752 pobj KO,with
R5881 T8755 T8754 punct /,KO
R5882 T8756 T8741 punct .,indicate
R5883 T8758 T8759 punct (,C
R5884 T8759 T8760 meta C,RRS
R5885 T8761 T8759 punct ),C
R5886 T8762 T8760 compound UV,RRS
R5887 T8763 T8760 punct -,RRS
R5888 T8764 T8760 punct ", ",RRS
R5889 T8765 T8766 det a,measure
R5890 T8766 T8760 appos measure,RRS
R5891 T8767 T8766 prep of,measure
R5892 T8768 T8769 npadvmod transcription,coupled
R5893 T8769 T8771 amod coupled,repair
R5894 T8770 T8769 punct -,coupled
R5895 T8771 T8767 pobj repair,of
R5896 T8772 T8771 prep of,repair
R5897 T8773 T8774 npadvmod UV,induced
R5898 T8774 T8776 amod induced,lesions
R5899 T8775 T8774 punct -,induced
R5900 T8776 T8772 pobj lesions,of
R5901 T8777 T8760 punct .,RRS
R5902 T8779 T8780 dep Number,included
R5903 T8781 T8779 prep of,Number
R5904 T8782 T8781 pobj experiments,of
R5905 T8783 T8780 punct : ,included
R5906 T8784 T8785 nsubj n,7
R5907 T8785 T8780 ccomp 7,included
R5908 T8786 T8785 punct =,7
R5909 T8787 T8788 punct (,TTD
R5910 T8788 T8785 parataxis TTD,7
R5911 T8789 T8788 compound XpdTTD,TTD
R5912 T8790 T8788 punct /,TTD
R5913 T8791 T8788 punct ),TTD
R5914 T8792 T8780 punct ", ",included
R5915 T8793 T8794 nsubj n,2
R5916 T8794 T8780 ccomp 2,included
R5917 T8795 T8794 punct =,2
R5918 T8796 T8797 punct (,KO
R5919 T8797 T8794 parataxis KO,2
R5920 T8798 T8797 compound XpdTTD,KO
R5921 T8799 T8797 punct /,KO
R5922 T8800 T8797 punct ),KO
R5923 T8801 T8780 punct ", ",included
R5924 T8802 T8803 nsubj n,4
R5925 T8803 T8780 ccomp 4,included
R5926 T8804 T8803 punct =,4
R5927 T8805 T8806 punct (,†XPCS
R5928 T8806 T8803 parataxis †XPCS,4
R5929 T8807 T8806 compound XpdTTD,†XPCS
R5930 T8808 T8806 punct /,†XPCS
R5931 T8809 T8806 punct ),†XPCS
R5932 T8810 T8780 punct ", ",included
R5933 T8811 T8812 nsubj n,2
R5934 T8812 T8780 ccomp 2,included
R5935 T8813 T8812 punct =,2
R5936 T8814 T8815 punct (,†XP
R5937 T8815 T8812 parataxis †XP,2
R5938 T8816 T8815 compound XpdTTD,†XP
R5939 T8817 T8815 punct /,†XP
R5940 T8818 T8815 punct ),†XP
R5941 T8819 T8780 punct ;,included
R5942 T8820 T8821 quantmod 1,2
R5943 T8821 T8823 nummod 2,lines
R5944 T8822 T8821 punct –,2
R5945 T8823 T8780 nsubjpass lines,included
R5946 T8824 T8823 compound cell,lines
R5947 T8825 T8823 prep per,lines
R5948 T8826 T8825 pobj genotype,per
R5949 T8827 T8780 auxpass were,included
R5950 T8828 T8780 prep in,included
R5951 T8829 T8830 det each,experiment
R5952 T8830 T8828 pobj experiment,in
R5953 T8831 T8780 punct .,included
R5954 T8833 T8834 punct (,D
R5955 T8834 T8835 meta D,activity
R5956 T8836 T8834 punct ),D
R5957 T8837 T8838 compound Incision,excision
R5958 T8838 T8835 compound excision,activity
R5959 T8839 T8838 punct /,excision
R5960 T8840 T8835 prep of,activity
R5961 T8841 T8840 pobj combinations,of
R5962 T8842 T8841 prep of,combinations
R5963 T8843 T8844 amod altered,complexes
R5964 T8844 T8842 pobj complexes,of
R5965 T8845 T8844 compound TFIIH,complexes
R5966 T8846 T8844 prep in,complexes
R5967 T8847 T8848 det a,reaction
R5968 T8848 T8846 pobj reaction,in
R5969 T8849 T8848 amod reconstituted,reaction
R5970 T8850 T8848 compound NER,reaction
R5971 T8851 T8835 punct .,activity
R5972 T8853 T8854 amod Equal,amounts
R5973 T8854 T8855 nsubjpass amounts,mixed
R5974 T8856 T8854 prep of,amounts
R5975 T8857 T8858 amod single,populations
R5976 T8858 T8856 pobj populations,of
R5977 T8859 T8857 cc or,single
R5978 T8860 T8857 conj mixed,single
R5979 T8861 T8858 prep of,populations
R5980 T8862 T8863 amod recombinant,TFIIHs
R5981 T8863 T8861 pobj TFIIHs,of
R5982 T8864 T8858 punct (,populations
R5983 T8865 T8858 acl containing,populations
R5984 T8866 T8865 dobj XPD,containing
R5985 T8867 T8866 punct ", ",XPD
R5986 T8868 T8866 conj XPB,XPD
R5987 T8869 T8868 punct ", ",XPB
R5988 T8870 T8868 conj p62,XPB
R5989 T8871 T8870 punct ", ",p62
R5990 T8872 T8870 conj p52,p62
R5991 T8873 T8872 punct ", ",p52
R5992 T8874 T8875 compound His,p44
R5993 T8875 T8872 conj p44,p52
R5994 T8876 T8875 punct -,p44
R5995 T8877 T8875 punct ", ",p44
R5996 T8878 T8879 compound Flag,p34
R5997 T8879 T8875 conj p34,p44
R5998 T8880 T8879 punct -,p34
R5999 T8881 T8879 punct ", ",p34
R6000 T8882 T8879 conj cdk7,p34
R6001 T8883 T8882 punct ", ",cdk7
R6002 T8884 T8885 compound cyclin,H
R6003 T8885 T8882 conj H,cdk7
R6004 T8886 T8885 punct ", ",H
R6005 T8887 T8885 conj Mat1,H
R6006 T8888 T8887 punct ", ",Mat1
R6007 T8889 T8887 cc and,Mat1
R6008 T8890 T8887 conj p8,Mat1
R6009 T8891 T8855 punct ),mixed
R6010 T8892 T8855 auxpass were,mixed
R6011 T8893 T8855 prep with,mixed
R6012 T8894 T8895 amod recombinant,XPG
R6013 T8895 T8893 pobj XPG,with
R6014 T8896 T8895 punct ", ",XPG
R6015 T8897 T8898 compound XPF,ERCC1
R6016 T8898 T8895 appos ERCC1,XPG
R6017 T8899 T8898 punct /,ERCC1
R6018 T8900 T8895 punct ", ",XPG
R6019 T8901 T8902 compound XPC,hHR23B
R6020 T8902 T8895 appos hHR23B,XPG
R6021 T8903 T8902 punct /,hHR23B
R6022 T8904 T8895 punct ", ",XPG
R6023 T8905 T8895 appos RPA,XPG
R6024 T8906 T8895 punct ", ",XPG
R6025 T8907 T8895 cc and,XPG
R6026 T8908 T8909 det a,substrate
R6027 T8909 T8895 conj substrate,XPG
R6028 T8910 T8909 amod radiolabelled,substrate
R6029 T8911 T8909 amod synthetic,substrate
R6030 T8912 T8909 compound NER,substrate
R6031 T8913 T8855 punct .,mixed
R6032 T8915 T8916 det The,products
R6033 T8916 T8918 nsubjpass products,visualised
R6034 T8917 T8916 compound excision,products
R6035 T8919 T8920 punct (,nucleotides
R6036 T8920 T8916 parataxis nucleotides,products
R6037 T8921 T8922 quantmod 26,34
R6038 T8922 T8920 nummod 34,nucleotides
R6039 T8923 T8922 punct –,34
R6040 T8924 T8920 prep in,nucleotides
R6041 T8925 T8924 pobj length,in
R6042 T8926 T8920 punct ),nucleotides
R6043 T8927 T8918 auxpass were,visualised
R6044 T8928 T8918 prep at,visualised
R6045 T8929 T8930 compound nucleotide,resolution
R6046 T8930 T8928 pobj resolution,at
R6047 T8931 T8918 prep on,visualised
R6048 T8932 T8933 det a,gel
R6049 T8933 T8931 pobj gel,on
R6050 T8934 T8933 amod denaturing,gel
R6051 T8935 T8933 compound polyacrylamide,gel
R6052 T8936 T8937 mark as,indicated
R6053 T8937 T8918 advcl indicated,visualised
R6054 T8938 T8918 punct .,visualised
R6055 T8941 T8942 det the,activity
R6056 T8942 T8940 dobj activity,Note
R6057 T8943 T8942 amod weak,activity
R6058 T8944 T8942 acl corresponding,activity
R6059 T8945 T8944 prep to,corresponding
R6060 T8946 T8947 det each,complex
R6061 T8947 T8945 pobj complex,to
R6062 T8948 T8947 amod single,complex
R6063 T8949 T8948 cc and,single
R6064 T8950 T8948 conj combined,single
R6065 T8951 T8947 compound TFIIH,complex
R6066 T8952 T8953 punct (,3
R6067 T8953 T8947 parataxis 3,complex
R6068 T8954 T8953 nmod lanes,3
R6069 T8955 T8956 punct –,8
R6070 T8956 T8953 prep 8,3
R6071 T8957 T8953 punct ),3
R6072 T8958 T8944 advcl relative,corresponding
R6073 T8959 T8958 prep to,relative
R6074 T8960 T8961 det the,wt
R6075 T8961 T8959 pobj wt,to
R6076 T8962 T8963 punct (,lane
R6077 T8963 T8961 parataxis lane,wt
R6078 T8964 T8963 nummod 1,lane
R6079 T8965 T8963 punct ),lane
R6080 T8966 T8961 cc and,wt
R6081 T8967 T8968 amod negative,controls
R6082 T8968 T8961 conj controls,wt
R6083 T8969 T8970 punct (,lane
R6084 T8970 T8968 parataxis lane,controls
R6085 T8971 T8970 nummod 2,lane
R6086 T8972 T8970 punct ),lane
R6087 T8973 T8940 punct .,Note
R6088 T8975 T8976 punct (,E
R6089 T8976 T8977 meta E,reduction
R6090 T8978 T8976 punct ),E
R6091 T8979 T8977 nmod Xpd,reduction
R6092 T8980 T8981 npadvmod dose,dependent
R6093 T8981 T8977 amod dependent,reduction
R6094 T8982 T8981 punct -,dependent
R6095 T8983 T8977 prep of,reduction
R6096 T8984 T8983 pobj TFIIH,of
R6097 T8985 T8977 prep in,reduction
R6098 T8986 T8987 amod homozygous,TTD
R6099 T8987 T8990 nmod TTD,cells
R6100 T8988 T8987 nmod XpdTTD,TTD
R6101 T8989 T8987 punct /,TTD
R6102 T8990 T8985 pobj cells,in
R6103 T8991 T8987 punct ", ",TTD
R6104 T8992 T8993 amod hemizygous,KO
R6105 T8993 T8987 conj KO,TTD
R6106 T8994 T8993 compound XpdTTD,KO
R6107 T8995 T8993 punct /,KO
R6108 T8996 T8993 punct ", ",KO
R6109 T8997 T8993 cc and,KO
R6110 T8998 T8999 nmod compound,†XPCS
R6111 T8999 T8993 conj †XPCS,KO
R6112 T9000 T8999 amod heterozygous,†XPCS
R6113 T9001 T8999 compound XpdTTD,†XPCS
R6114 T9002 T8999 punct /,†XPCS
R6115 T9003 T8999 cc and,†XPCS
R6116 T9004 T9005 compound XpdTTD,†XP
R6117 T9005 T8999 conj †XP,†XPCS
R6118 T9006 T9005 punct /,†XP
R6119 T9007 T8977 prep by,reduction
R6120 T9008 T9009 amod comparative,immunofluorescence
R6121 T9009 T9007 pobj immunofluorescence,by
R6122 T9010 T9009 prep of,immunofluorescence
R6123 T9011 T9012 det the,subunit
R6124 T9012 T9010 pobj subunit,of
R6125 T9013 T9012 compound p62,subunit
R6126 T9014 T9012 prep of,subunit
R6127 T9015 T9014 pobj TFIIH,of
R6128 T9016 T8977 punct .,reduction
R6129 T9018 T9019 amod Roman,numerals
R6130 T9019 T9020 nsubj numerals,represent
R6131 T9021 T9022 amod different,slides
R6132 T9022 T9020 dobj slides,represent
R6133 T9023 T9022 amod microscopic,slides
R6134 T9024 T9020 cc and,represent
R6135 T9025 T9026 amod Arabic,numerals
R6136 T9026 T9027 nsubj numerals,lines
R6137 T9027 T9020 conj lines,represent
R6138 T9028 T9027 amod different,lines
R6139 T9029 T9027 compound cell,lines
R6140 T9030 T9027 acl labelled,lines
R6141 T9031 T9032 mark as,follows
R6142 T9032 T9030 advcl follows,labelled
R6143 T9033 T9027 punct : ,lines
R6144 T9034 T9035 punct (,I
R6145 T9035 T9036 meta I,cells
R6146 T9036 T9027 dep cells,lines
R6147 T9037 T9035 punct ),I
R6148 T9038 T9036 compound wt,cells
R6149 T9039 T9040 punct (,1
R6150 T9040 T9036 parataxis 1,cells
R6151 T9041 T9040 punct ),1
R6152 T9042 T9036 acl labelled,cells
R6153 T9043 T9042 prep with,labelled
R6154 T9044 T9045 nummod 2,μm
R6155 T9045 T9047 compound μm,beads
R6156 T9046 T9045 punct -,μm
R6157 T9047 T9043 pobj beads,with
R6158 T9048 T9036 punct ", ",cells
R6159 T9049 T9050 compound XpdTTD,TTD
R6160 T9050 T9052 compound TTD,cells
R6161 T9051 T9050 punct /,TTD
R6162 T9052 T9036 conj cells,cells
R6163 T9053 T9054 punct (,2
R6164 T9054 T9052 parataxis 2,cells
R6165 T9055 T9054 punct ),2
R6166 T9056 T9052 prep with,cells
R6167 T9057 T9058 nummod 0.79,μm
R6168 T9058 T9060 compound μm,beads
R6169 T9059 T9058 punct -,μm
R6170 T9060 T9056 pobj beads,with
R6171 T9061 T9052 punct ", ",cells
R6172 T9062 T9052 cc and,cells
R6173 T9063 T9064 compound XpdTTD,KO
R6174 T9064 T9066 compound KO,cells
R6175 T9065 T9064 punct /,KO
R6176 T9066 T9052 conj cells,cells
R6177 T9067 T9068 punct (,3
R6178 T9068 T9066 parataxis 3,cells
R6179 T9069 T9068 punct ),3
R6180 T9070 T9066 prep with,cells
R6181 T9071 T9072 det no,beads
R6182 T9072 T9070 pobj beads,with
R6183 T9073 T9036 punct ;,cells
R6184 T9074 T9075 punct (,II
R6185 T9075 T9076 meta II,cells
R6186 T9076 T9036 conj cells,cells
R6187 T9077 T9075 punct ),II
R6188 T9078 T9076 compound wt,cells
R6189 T9079 T9080 punct (,1
R6190 T9080 T9076 parataxis 1,cells
R6191 T9081 T9080 punct ),1
R6192 T9082 T9076 acl labelled,cells
R6193 T9083 T9082 prep with,labelled
R6194 T9084 T9085 nummod 0.79,μm
R6195 T9085 T9087 compound μm,beads
R6196 T9086 T9085 punct -,μm
R6197 T9087 T9083 pobj beads,with
R6198 T9088 T9076 cc and,cells
R6199 T9089 T9090 compound XpdTTD,†XPCS
R6200 T9090 T9092 compound †XPCS,cells
R6201 T9091 T9090 punct /,†XPCS
R6202 T9092 T9076 conj cells,cells
R6203 T9093 T9094 punct (,4
R6204 T9094 T9092 parataxis 4,cells
R6205 T9095 T9094 punct ),4
R6206 T9096 T9092 prep with,cells
R6207 T9097 T9098 det no,beads
R6208 T9098 T9096 pobj beads,with
R6209 T9099 T9076 punct ;,cells
R6210 T9100 T9076 cc and,cells
R6211 T9101 T9102 punct (,III
R6212 T9102 T9103 meta III,cells
R6213 T9103 T9076 conj cells,cells
R6214 T9104 T9102 punct ),III
R6215 T9105 T9103 compound wt,cells
R6216 T9106 T9107 punct (,1
R6217 T9107 T9103 parataxis 1,cells
R6218 T9108 T9107 punct ),1
R6219 T9109 T9103 acl labelled,cells
R6220 T9110 T9109 prep with,labelled
R6221 T9111 T9112 nummod 0.79,μm
R6222 T9112 T9114 compound μm,beads
R6223 T9113 T9112 punct -,μm
R6224 T9114 T9110 pobj beads,with
R6225 T9115 T9103 cc and,cells
R6226 T9116 T9117 compound XpdTTD,†XP
R6227 T9117 T9119 compound †XP,cells
R6228 T9118 T9117 punct /,†XP
R6229 T9119 T9103 conj cells,cells
R6230 T9120 T9121 punct (,5
R6231 T9121 T9119 parataxis 5,cells
R6232 T9122 T9121 punct ),5
R6233 T9123 T9119 prep with,cells
R6234 T9124 T9125 det no,beads
R6235 T9125 T9123 pobj beads,with
R6236 T9126 T9027 punct .,lines
R6237 T9128 T9129 punct (,F
R6238 T9129 T9130 meta F,Quantification
R6239 T9131 T9129 punct ),F
R6240 T9132 T9130 prep of,Quantification
R6241 T9133 T9134 amod immunofluorescent,signal
R6242 T9134 T9132 pobj signal,of
R6243 T9135 T9134 prep from,signal
R6244 T9136 T9137 advmod at,50
R6245 T9137 T9139 nummod 50,nuclei
R6246 T9138 T9137 advmod least,50
R6247 T9139 T9135 pobj nuclei,from
R6248 T9140 T9139 prep per,nuclei
R6249 T9141 T9142 compound cell,line
R6250 T9142 T9140 pobj line,per
R6251 T9143 T9139 cc and,nuclei
R6252 T9144 T9145 quantmod 2,6
R6253 T9145 T9147 nummod 6,experiments
R6254 T9146 T9145 punct –,6
R6255 T9147 T9139 conj experiments,nuclei
R6256 T9148 T9147 prep per,experiments
R6257 T9149 T9148 pobj genotype,per
R6258 T9150 T9130 punct .,Quantification
R6259 T9152 T9153 nsubjpass Bars,depicted
R6260 T9154 T9152 acl representing,Bars
R6261 T9155 T9154 dobj cells,representing
R6262 T9156 T9155 acl analysed,cells
R6263 T9157 T9156 prep on,analysed
R6264 T9158 T9159 det the,slide
R6265 T9159 T9157 pobj slide,on
R6266 T9160 T9159 amod same,slide
R6267 T9161 T9159 amod microscopic,slide
R6268 T9162 T9153 auxpass are,depicted
R6269 T9163 T9153 npadvmod side,depicted
R6270 T9164 T9163 prep by,side
R6271 T9165 T9164 pobj side,by
R6272 T9166 T9153 punct ", ",depicted
R6273 T9167 T9153 prep with,depicted
R6274 T9168 T9167 pobj wt,with
R6275 T9169 T9168 acl set,wt
R6276 T9170 T9169 prep at,set
R6277 T9171 T9172 nummod 100,%
R6278 T9172 T9170 pobj %,at
R6279 T9173 T9153 punct .,depicted
R6280 T9175 T9176 det The,value
R6281 T9176 T9179 nsubj value,indicates
R6282 T9177 T9176 compound p,value
R6283 T9178 T9176 punct -,value
R6284 T9180 T9181 amod minimum,difference
R6285 T9181 T9179 dobj difference,indicates
R6286 T9182 T9181 amod significant,difference
R6287 T9183 T9181 prep between,difference
R6288 T9184 T9183 pobj wt,between
R6289 T9185 T9184 cc and,wt
R6290 T9186 T9187 det the,lines
R6291 T9187 T9184 conj lines,wt
R6292 T9188 T9187 amod indicated,lines
R6293 T9189 T9187 compound cell,lines
R6294 T9190 T9187 acl analysed,lines
R6295 T9191 T9190 prep on,analysed
R6296 T9192 T9193 det the,slide
R6297 T9193 T9191 pobj slide,on
R6298 T9194 T9193 amod same,slide
R6299 T9195 T9193 amod microscopic,slide
R6300 T9196 T9181 prep within,difference
R6301 T9197 T9198 nummod one,experiment
R6302 T9198 T9196 pobj experiment,within
R6303 T9199 T9179 punct .,indicates