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PMC:1584416 / 16206-17106 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2792 0-2 TO denotes To
T2793 3-12 VB denotes determine
T2795 13-20 IN denotes whether
T2797 21-24 DT denotes the
T2799 25-35 JJ denotes homozygous
T2800 36-42 JJ denotes lethal
T2801 43-51 NN denotes Xpd†XPCS
T2798 52-58 NN denotes allele
T2796 59-62 VBD denotes was
T2802 63-69 JJ denotes unique
T2803 70-72 IN denotes in
T2804 73-76 PRP$ denotes its
T2805 77-84 NN denotes ability
T2806 85-87 TO denotes to
T2807 88-98 VB denotes ameliorate
T2808 99-107 NNS denotes symptoms
T2809 108-118 VBN denotes associated
T2810 119-123 IN denotes with
T2811 124-127 DT denotes the
T2813 128-134 NN denotes XpdTTD
T2812 135-141 NN denotes allele
T2814 141-143 , denotes ,
T2815 143-145 PRP denotes we
T2794 146-155 VBD denotes generated
T2816 156-164 NN denotes compound
T2818 165-177 JJ denotes heterozygous
T2819 178-184 NN denotes XpdTTD
T2821 184-185 HYPH denotes /
T2820 185-188 NN denotes †XP
T2817 189-193 NNS denotes mice
T2822 194-196 IN denotes by
T2823 197-205 VBG denotes crossing
T2824 206-209 DT denotes the
T2826 210-223 VBG denotes corresponding
T2827 224-236 JJ denotes heterozygous
T2825 237-244 NNS denotes animals
T2828 244-245 . denotes .
T2829 245-691 sentence denotes Similar to the Xpd †XPCS allele, the homozygous lethal Xpd †XP allele rescued cutaneous symptoms including hair loss (except locally during the first round; unpublished data), reduced cysteine content (cysteine index 9.3 ± 0.9 standard deviation [87% of wt], p = 0.01 versus TTD), ageing-associated premature cachexia (males and females were 36.1 ± 6.4 g [93% of wt] and 39.2 ± 3.2 g [116% of wt], respectively), and reduced life span (Table 2).
T2830 246-253 JJ denotes Similar
T2832 254-256 IN denotes to
T2833 257-260 DT denotes the
T2835 261-270 NN denotes Xpd †XPCS
T2834 271-277 NN denotes allele
T2836 277-279 , denotes ,
T2837 279-282 DT denotes the
T2839 283-293 JJ denotes homozygous
T2840 294-300 JJ denotes lethal
T2841 301-308 NN denotes Xpd †XP
T2838 309-315 NN denotes allele
T2831 316-323 VBD denotes rescued
T2842 324-333 JJ denotes cutaneous
T2843 334-342 NNS denotes symptoms
T2844 343-352 VBG denotes including
T2845 353-357 NN denotes hair
T2846 358-362 NN denotes loss
T2847 363-364 -LRB- denotes (
T2849 364-370 IN denotes except
T2850 371-378 RB denotes locally
T2851 379-385 IN denotes during
T2852 386-389 DT denotes the
T2854 390-395 JJ denotes first
T2853 396-401 NN denotes round
T2855 401-402 : denotes ;
T2856 403-414 JJ denotes unpublished
T2848 415-419 NNS denotes data
T2857 419-420 -RRB- denotes )
T2858 420-422 , denotes ,
T2859 422-429 VBN denotes reduced
T2861 430-438 NN denotes cysteine
T2860 439-446 NN denotes content
T2862 447-448 -LRB- denotes (
T2864 448-456 NN denotes cysteine
T2863 457-462 NN denotes index
T2865 463-466 CD denotes 9.3
T2866 467-468 SYM denotes ±
T2867 469-472 CD denotes 0.9
T2869 473-481 JJ denotes standard
T2868 482-491 NN denotes deviation
T2870 492-493 -LRB- denotes [
T2872 493-495 CD denotes 87
T2871 495-496 NN denotes %
T2873 497-499 IN denotes of
T2874 500-502 NN denotes wt
T2875 502-503 -RRB- denotes ]
T2876 503-505 , denotes ,
T2877 505-506 NN denotes p
T2879 507-508 SYM denotes =
T2880 509-513 CD denotes 0.01
T2881 514-520 CC denotes versus
T2878 521-524 NN denotes TTD
T2882 524-525 -RRB- denotes )
T2883 525-527 , denotes ,
T2884 527-533 NN denotes ageing
T2886 533-534 HYPH denotes -
T2885 534-544 VBN denotes associated
T2888 545-554 JJ denotes premature
T2887 555-563 NN denotes cachexia
T2889 564-565 -LRB- denotes (
T2891 565-570 NNS denotes males
T2892 571-574 CC denotes and
T2893 575-582 NNS denotes females
T2890 583-587 VBD denotes were
T2894 588-592 CD denotes 36.1
T2896 593-594 SYM denotes ±
T2895 595-598 CD denotes 6.4
T2897 599-600 NNS denotes g
T2898 601-602 -LRB- denotes [
T2900 602-604 CD denotes 93
T2899 604-605 NN denotes %
T2901 606-608 IN denotes of
T2902 609-611 NN denotes wt
T2903 611-612 -RRB- denotes ]
T2904 613-616 CC denotes and
T2905 617-621 CD denotes 39.2
T2907 622-623 SYM denotes ±
T2906 624-627 CD denotes 3.2
T2908 628-629 NNS denotes g
T2909 630-631 -LRB- denotes [
T2911 631-634 CD denotes 116
T2910 634-635 NN denotes %
T2912 636-638 IN denotes of
T2913 639-641 NN denotes wt
T2914 641-642 -RRB- denotes ]
T2915 642-644 , denotes ,
T2916 644-656 RB denotes respectively
T2917 656-657 -RRB- denotes )
T2918 657-659 , denotes ,
T2919 659-662 CC denotes and
T2920 663-670 VBN denotes reduced
T2922 671-675 NN denotes life
T2921 676-680 NN denotes span
T2923 681-682 -LRB- denotes (
T2924 682-687 NN denotes Table
T2925 688-689 CD denotes 2
T2926 689-690 -RRB- denotes )
T2927 690-691 . denotes .
T2928 691-900 sentence denotes Taken together, these data indicate that two independent alleles, which on their own are unable to support viability (Table 1), were nonetheless able to ameliorate TTD-associated phenotypes in vivo (Table 2).
T2929 692-697 VBN denotes Taken
T2931 698-706 RB denotes together
T2932 706-708 , denotes ,
T2933 708-713 DT denotes these
T2934 714-718 NNS denotes data
T2930 719-727 VBP denotes indicate
T2935 728-732 IN denotes that
T2937 733-736 CD denotes two
T2939 737-748 JJ denotes independent
T2938 749-756 NNS denotes alleles
T2940 756-758 , denotes ,
T2941 758-763 WDT denotes which
T2943 764-766 IN denotes on
T2944 767-772 PRP$ denotes their
T2945 773-776 NN denotes own
T2942 777-780 VBP denotes are
T2946 781-787 JJ denotes unable
T2947 788-790 TO denotes to
T2948 791-798 VB denotes support
T2949 799-808 NN denotes viability
T2950 809-810 -LRB- denotes (
T2951 810-815 NN denotes Table
T2952 816-817 CD denotes 1
T2953 817-818 -RRB- denotes )
T2954 818-820 , denotes ,
T2936 820-824 VBD denotes were
T2955 825-836 RB denotes nonetheless
T2956 837-841 JJ denotes able
T2957 842-844 TO denotes to
T2958 845-855 VB denotes ameliorate
T2959 856-859 NN denotes TTD
T2961 859-860 HYPH denotes -
T2960 860-870 VBN denotes associated
T2962 871-881 NNS denotes phenotypes
T2963 882-884 FW denotes in
T2964 885-889 FW denotes vivo
T2965 890-891 -LRB- denotes (
T2966 891-896 NN denotes Table
T2967 897-898 CD denotes 2
T2968 898-899 -RRB- denotes )
T2969 899-900 . denotes .
R1910 T2792 T2793 aux To,determine
R1911 T2793 T2794 advcl determine,generated
R1912 T2795 T2796 mark whether,was
R1913 T2796 T2793 ccomp was,determine
R1914 T2797 T2798 det the,allele
R1915 T2798 T2796 nsubj allele,was
R1916 T2799 T2798 amod homozygous,allele
R1917 T2800 T2798 amod lethal,allele
R1918 T2801 T2798 compound Xpd†XPCS,allele
R1919 T2802 T2796 acomp unique,was
R1920 T2803 T2802 prep in,unique
R1921 T2804 T2805 poss its,ability
R1922 T2805 T2803 pobj ability,in
R1923 T2806 T2807 aux to,ameliorate
R1924 T2807 T2805 acl ameliorate,ability
R1925 T2808 T2807 dobj symptoms,ameliorate
R1926 T2809 T2808 acl associated,symptoms
R1927 T2810 T2809 prep with,associated
R1928 T2811 T2812 det the,allele
R1929 T2812 T2810 pobj allele,with
R1930 T2813 T2812 compound XpdTTD,allele
R1931 T2814 T2794 punct ", ",generated
R1932 T2815 T2794 nsubj we,generated
R1933 T2816 T2817 nmod compound,mice
R1934 T2817 T2794 dobj mice,generated
R1935 T2818 T2817 amod heterozygous,mice
R1936 T2819 T2820 compound XpdTTD,†XP
R1937 T2820 T2817 compound †XP,mice
R1938 T2821 T2820 punct /,†XP
R1939 T2822 T2794 prep by,generated
R1940 T2823 T2822 pcomp crossing,by
R1941 T2824 T2825 det the,animals
R1942 T2825 T2823 dobj animals,crossing
R1943 T2826 T2825 amod corresponding,animals
R1944 T2827 T2825 amod heterozygous,animals
R1945 T2828 T2794 punct .,generated
R1946 T2830 T2831 advcl Similar,rescued
R1947 T2832 T2830 prep to,Similar
R1948 T2833 T2834 det the,allele
R1949 T2834 T2832 pobj allele,to
R1950 T2835 T2834 compound Xpd †XPCS,allele
R1951 T2836 T2831 punct ", ",rescued
R1952 T2837 T2838 det the,allele
R1953 T2838 T2831 nsubj allele,rescued
R1954 T2839 T2838 amod homozygous,allele
R1955 T2840 T2838 amod lethal,allele
R1956 T2841 T2838 compound Xpd †XP,allele
R1957 T2842 T2843 amod cutaneous,symptoms
R1958 T2843 T2831 dobj symptoms,rescued
R1959 T2844 T2843 prep including,symptoms
R1960 T2845 T2846 compound hair,loss
R1961 T2846 T2844 pobj loss,including
R1962 T2847 T2848 punct (,data
R1963 T2848 T2846 parataxis data,loss
R1964 T2849 T2848 prep except,data
R1965 T2850 T2849 pcomp locally,except
R1966 T2851 T2850 prep during,locally
R1967 T2852 T2853 det the,round
R1968 T2853 T2851 pobj round,during
R1969 T2854 T2853 amod first,round
R1970 T2855 T2848 punct ;,data
R1971 T2856 T2848 amod unpublished,data
R1972 T2857 T2848 punct ),data
R1973 T2858 T2846 punct ", ",loss
R1974 T2859 T2860 amod reduced,content
R1975 T2860 T2846 conj content,loss
R1976 T2861 T2860 compound cysteine,content
R1977 T2862 T2863 punct (,index
R1978 T2863 T2860 parataxis index,content
R1979 T2864 T2863 compound cysteine,index
R1980 T2865 T2863 npadvmod 9.3,index
R1981 T2866 T2865 punct ±,9.3
R1982 T2867 T2868 nummod 0.9,deviation
R1983 T2868 T2865 appos deviation,9.3
R1984 T2869 T2868 amod standard,deviation
R1985 T2870 T2871 punct [,%
R1986 T2871 T2865 parataxis %,9.3
R1987 T2872 T2871 nummod 87,%
R1988 T2873 T2871 prep of,%
R1989 T2874 T2873 pobj wt,of
R1990 T2875 T2871 punct ],%
R1991 T2876 T2863 punct ", ",index
R1992 T2877 T2878 nsubj p,TTD
R1993 T2878 T2863 ccomp TTD,index
R1994 T2879 T2878 punct =,TTD
R1995 T2880 T2878 nummod 0.01,TTD
R1996 T2881 T2878 cc versus,TTD
R1997 T2882 T2863 punct ),index
R1998 T2883 T2860 punct ", ",content
R1999 T2884 T2885 npadvmod ageing,associated
R2000 T2885 T2887 amod associated,cachexia
R2001 T2886 T2885 punct -,associated
R2002 T2887 T2860 conj cachexia,content
R2003 T2888 T2887 amod premature,cachexia
R2004 T2889 T2890 punct (,were
R2005 T2890 T2887 parataxis were,cachexia
R2006 T2891 T2890 nsubj males,were
R2007 T2892 T2891 cc and,males
R2008 T2893 T2891 conj females,males
R2009 T2894 T2895 nummod 36.1,6.4
R2010 T2895 T2897 nummod 6.4,g
R2011 T2896 T2895 punct ±,6.4
R2012 T2897 T2890 attr g,were
R2013 T2898 T2899 punct [,%
R2014 T2899 T2897 parataxis %,g
R2015 T2900 T2899 nummod 93,%
R2016 T2901 T2899 prep of,%
R2017 T2902 T2901 pobj wt,of
R2018 T2903 T2899 punct ],%
R2019 T2904 T2897 cc and,g
R2020 T2905 T2906 nummod 39.2,3.2
R2021 T2906 T2908 nummod 3.2,g
R2022 T2907 T2906 punct ±,3.2
R2023 T2908 T2897 conj g,g
R2024 T2909 T2910 punct [,%
R2025 T2910 T2908 parataxis %,g
R2026 T2911 T2910 nummod 116,%
R2027 T2912 T2910 prep of,%
R2028 T2913 T2912 pobj wt,of
R2029 T2914 T2910 punct ],%
R2030 T2915 T2890 punct ", ",were
R2031 T2916 T2890 advmod respectively,were
R2032 T2917 T2890 punct ),were
R2033 T2918 T2887 punct ", ",cachexia
R2034 T2919 T2887 cc and,cachexia
R2035 T2920 T2921 amod reduced,span
R2036 T2921 T2887 conj span,cachexia
R2037 T2922 T2921 compound life,span
R2038 T2923 T2924 punct (,Table
R2039 T2924 T2831 parataxis Table,rescued
R2040 T2925 T2924 nummod 2,Table
R2041 T2926 T2924 punct ),Table
R2042 T2927 T2831 punct .,rescued
R2043 T2929 T2930 advcl Taken,indicate
R2044 T2931 T2929 advmod together,Taken
R2045 T2932 T2930 punct ", ",indicate
R2046 T2933 T2934 det these,data
R2047 T2934 T2930 nsubj data,indicate
R2048 T2935 T2936 mark that,were
R2049 T2936 T2930 ccomp were,indicate
R2050 T2937 T2938 nummod two,alleles
R2051 T2938 T2936 nsubj alleles,were
R2052 T2939 T2938 amod independent,alleles
R2053 T2940 T2938 punct ", ",alleles
R2054 T2941 T2942 dep which,are
R2055 T2942 T2938 relcl are,alleles
R2056 T2943 T2942 prep on,are
R2057 T2944 T2945 poss their,own
R2058 T2945 T2943 pobj own,on
R2059 T2946 T2942 acomp unable,are
R2060 T2947 T2948 aux to,support
R2061 T2948 T2946 xcomp support,unable
R2062 T2949 T2948 dobj viability,support
R2063 T2950 T2951 punct (,Table
R2064 T2951 T2948 parataxis Table,support
R2065 T2952 T2951 nummod 1,Table
R2066 T2953 T2951 punct ),Table
R2067 T2954 T2936 punct ", ",were
R2068 T2955 T2936 advmod nonetheless,were
R2069 T2956 T2936 acomp able,were
R2070 T2957 T2958 aux to,ameliorate
R2071 T2958 T2956 xcomp ameliorate,able
R2072 T2959 T2960 npadvmod TTD,associated
R2073 T2960 T2962 amod associated,phenotypes
R2074 T2961 T2960 punct -,associated
R2075 T2962 T2958 dobj phenotypes,ameliorate
R2076 T2963 T2964 advmod in,vivo
R2077 T2964 T2958 advmod vivo,ameliorate
R2078 T2965 T2966 punct (,Table
R2079 T2966 T2958 parataxis Table,ameliorate
R2080 T2967 T2966 nummod 2,Table
R2081 T2968 T2966 punct ),Table
R2082 T2969 T2930 punct .,indicate