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Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2575 20-28 NNS denotes Features
T2576 29-31 IN denotes in
T2577 32-35 NN denotes TTD
T2578 36-40 NNS denotes Mice
T2579 41-43 IN denotes by
T2580 44-54 JJ denotes Homozygous
T2582 55-61 JJ denotes Lethal
T2583 62-65 NN denotes Xpd
T2581 66-73 NNS denotes Alleles
T2584 73-307 sentence denotes Because patients with TTD, XPCS, and CS (but not XP) and the corresponding mouse models share similar accelerated progeroid symptoms [12,13,15,23], we next addressed ageing-related parameters in compound heterozygous mice (Figure 3).
T2585 74-81 IN denotes Because
T2587 82-90 NNS denotes patients
T2588 91-95 IN denotes with
T2589 96-99 NN denotes TTD
T2590 99-101 , denotes ,
T2591 101-105 NN denotes XPCS
T2592 105-107 , denotes ,
T2593 107-110 CC denotes and
T2594 111-113 NN denotes CS
T2595 114-115 -LRB- denotes (
T2596 115-118 CC denotes but
T2597 119-122 RB denotes not
T2598 123-125 NN denotes XP
T2599 125-126 -RRB- denotes )
T2600 127-130 CC denotes and
T2601 131-134 DT denotes the
T2603 135-148 VBG denotes corresponding
T2604 149-154 NN denotes mouse
T2602 155-161 NNS denotes models
T2586 162-167 VBP denotes share
T2606 168-175 JJ denotes similar
T2608 176-187 VBN denotes accelerated
T2609 188-197 NN denotes progeroid
T2607 198-206 NNS denotes symptoms
T2610 207-208 -LRB- denotes [
T2612 208-210 CD denotes 12
T2613 210-211 , denotes ,
T2614 211-213 CD denotes 13
T2615 213-214 , denotes ,
T2616 214-216 CD denotes 15
T2617 216-217 , denotes ,
T2611 217-219 CD denotes 23
T2618 219-220 -RRB- denotes ]
T2619 220-222 , denotes ,
T2620 222-224 PRP denotes we
T2621 225-229 RB denotes next
T2605 230-239 VBD denotes addressed
T2622 240-246 JJ denotes ageing
T2624 246-247 HYPH denotes -
T2623 247-254 JJ denotes related
T2625 255-265 NNS denotes parameters
T2626 266-268 IN denotes in
T2627 269-277 JJ denotes compound
T2629 278-290 JJ denotes heterozygous
T2628 291-295 NNS denotes mice
T2630 296-297 -LRB- denotes (
T2631 297-303 NN denotes Figure
T2632 304-305 CD denotes 3
T2633 305-306 -RRB- denotes )
T2634 306-307 . denotes .
T2635 307-570 sentence denotes Whereas XpdTTD/TTD animals show reduced bone mineral density as an indication of the early onset of osteoporosis before ~14 mo of age [15], tail vertebrae from compound heterozygous XpdTTD/†XPCS mice were comparable to wt even at 20 mo of age (Figure 3B and 3C).
T2636 308-315 IN denotes Whereas
T2638 316-322 NN denotes XpdTTD
T2640 322-323 HYPH denotes /
T2639 323-326 NN denotes TTD
T2641 327-334 NNS denotes animals
T2637 335-339 VBP denotes show
T2643 340-347 VBN denotes reduced
T2645 348-352 NN denotes bone
T2646 353-360 NN denotes mineral
T2644 361-368 NN denotes density
T2647 369-371 IN denotes as
T2648 372-374 DT denotes an
T2649 375-385 NN denotes indication
T2650 386-388 IN denotes of
T2651 389-392 DT denotes the
T2653 393-398 JJ denotes early
T2652 399-404 NN denotes onset
T2654 405-407 IN denotes of
T2655 408-420 NN denotes osteoporosis
T2656 421-427 IN denotes before
T2657 428-429 SYM denotes ~
T2658 429-431 CD denotes 14
T2659 432-434 NNS denotes mo
T2660 435-437 IN denotes of
T2661 438-441 NN denotes age
T2662 442-443 -LRB- denotes [
T2663 443-445 CD denotes 15
T2664 445-446 -RRB- denotes ]
T2665 446-448 , denotes ,
T2666 448-452 NN denotes tail
T2667 453-462 NNS denotes vertebrae
T2668 463-467 IN denotes from
T2669 468-476 NN denotes compound
T2671 477-489 JJ denotes heterozygous
T2672 490-496 NN denotes XpdTTD
T2674 496-497 HYPH denotes /
T2673 497-502 NN denotes †XPCS
T2670 503-507 NNS denotes mice
T2642 508-512 VBD denotes were
T2675 513-523 JJ denotes comparable
T2676 524-526 IN denotes to
T2677 527-529 NN denotes wt
T2678 530-534 RB denotes even
T2679 535-537 IN denotes at
T2680 538-540 CD denotes 20
T2681 541-543 NNS denotes mo
T2682 544-546 IN denotes of
T2683 547-550 NN denotes age
T2684 551-552 -LRB- denotes (
T2686 552-558 NN denotes Figure
T2685 559-561 NN denotes 3B
T2687 562-565 CC denotes and
T2688 566-568 NN denotes 3C
T2689 568-569 -RRB- denotes )
T2690 569-570 . denotes .
T2691 570-742 sentence denotes Furthermore, whereas XpdTTD/TTD mice developed kyphosis earlier than wt animals (onset ~3 mo versus 12–20 mo), compound heterozygous XpdTTD/†XPCS mice did not (Figure 3B).
T2692 571-582 RB denotes Furthermore
T2694 582-584 , denotes ,
T2695 584-591 IN denotes whereas
T2697 592-598 NN denotes XpdTTD
T2699 598-599 HYPH denotes /
T2698 599-602 NN denotes TTD
T2700 603-607 NNS denotes mice
T2696 608-617 VBD denotes developed
T2701 618-626 NN denotes kyphosis
T2702 627-634 RBR denotes earlier
T2703 635-639 IN denotes than
T2704 640-642 NN denotes wt
T2705 643-650 NNS denotes animals
T2706 651-652 -LRB- denotes (
T2707 652-657 NN denotes onset
T2708 658-659 SYM denotes ~
T2709 659-660 CD denotes 3
T2710 661-663 NNS denotes mo
T2711 664-670 CC denotes versus
T2712 671-673 CD denotes 12
T2714 673-674 SYM denotes –
T2713 674-676 CD denotes 20
T2715 677-679 NNS denotes mo
T2716 679-680 -RRB- denotes )
T2717 680-682 , denotes ,
T2718 682-690 JJ denotes compound
T2720 691-703 JJ denotes heterozygous
T2721 704-710 NN denotes XpdTTD
T2723 710-711 HYPH denotes /
T2722 711-716 NN denotes †XPCS
T2719 717-721 NNS denotes mice
T2724 722-725 VBD denotes did
T2725 726-729 RB denotes not
T2726 730-731 -LRB- denotes (
T2727 731-737 NN denotes Figure
T2693 738-740 NN denotes 3B
T2728 740-741 -RRB- denotes )
T2729 741-742 . denotes .
T2730 742-954 sentence denotes Overall appearance and body weight curves revealed that TTD-associated age-related premature cachexia and lack of general fitness were fully rescued in compound heterozygous XpdTTD/†XPCS mice (Figure 3A and 3D).
T2731 743-750 JJ denotes Overall
T2732 751-761 NN denotes appearance
T2734 762-765 CC denotes and
T2735 766-770 NN denotes body
T2736 771-777 NN denotes weight
T2737 778-784 NNS denotes curves
T2733 785-793 VBD denotes revealed
T2738 794-798 IN denotes that
T2740 799-802 NN denotes TTD
T2742 802-803 HYPH denotes -
T2741 803-813 JJ denotes associated
T2744 814-817 NN denotes age
T2746 817-818 HYPH denotes -
T2745 818-825 JJ denotes related
T2747 826-835 JJ denotes premature
T2743 836-844 NN denotes cachexia
T2748 845-848 CC denotes and
T2749 849-853 NN denotes lack
T2750 854-856 IN denotes of
T2751 857-864 JJ denotes general
T2752 865-872 NN denotes fitness
T2753 873-877 VBD denotes were
T2754 878-883 RB denotes fully
T2739 884-891 VBN denotes rescued
T2755 892-894 IN denotes in
T2756 895-903 JJ denotes compound
T2758 904-916 JJ denotes heterozygous
T2759 917-923 NN denotes XpdTTD
T2761 923-924 HYPH denotes /
T2760 924-929 NN denotes †XPCS
T2757 930-934 NNS denotes mice
T2762 935-936 -LRB- denotes (
T2764 936-942 NN denotes Figure
T2763 943-945 NN denotes 3A
T2765 946-949 CC denotes and
T2766 950-952 NN denotes 3D
T2767 952-953 -RRB- denotes )
T2768 953-954 . denotes .
T2769 954-1055 sentence denotes Finally, the life span of compound heterozygotes was extended relative to XpdTTD/TTD mice (Table 2).
T2770 955-962 RB denotes Finally
T2772 962-964 , denotes ,
T2773 964-967 DT denotes the
T2775 968-972 NN denotes life
T2774 973-977 NN denotes span
T2776 978-980 IN denotes of
T2777 981-989 JJ denotes compound
T2778 990-1003 NNS denotes heterozygotes
T2779 1004-1007 VBD denotes was
T2771 1008-1016 VBN denotes extended
T2780 1017-1025 JJ denotes relative
T2781 1026-1028 IN denotes to
T2782 1029-1035 NN denotes XpdTTD
T2784 1035-1036 HYPH denotes /
T2783 1036-1039 NN denotes TTD
T2785 1040-1044 NNS denotes mice
T2786 1045-1046 -LRB- denotes (
T2787 1046-1051 NN denotes Table
T2788 1052-1053 CD denotes 2
T2789 1053-1054 -RRB- denotes )
T2790 1054-1055 . denotes .
T2791 1055-2665 sentence denotes Figure 3 Rescue of TTD-Associated Segmental Progeroid Features in Compound Heterozygous Xpd TTD/†XPCS Mice (A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice. Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice. (B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice. Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right). Note the absence of these features in the XpdTTD / † XPCS mouse. (C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice. The p-values indicate the significance of the difference relative to XpdTTD/TTD. Error bars indicate SEM. (D) Body weight curves as a function of time. Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice. Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks. Error bars indicate SEM. Table 2 Pleiotropic Xpd Biallelic Effects in Mice and Cells To determine whether the homozygous lethal Xpd†XPCS allele was unique in its ability to ameliorate symptoms associated with the XpdTTD allele, we generated compound heterozygous XpdTTD/†XP mice by crossing the corresponding heterozygous animals.
T8041 1066-1072 NN denotes Rescue
T8042 1073-1075 IN denotes of
T8043 1076-1079 NN denotes TTD
T8045 1079-1080 HYPH denotes -
T8044 1080-1090 JJ denotes Associated
T8047 1091-1100 JJ denotes Segmental
T8048 1101-1110 JJ denotes Progeroid
T8046 1111-1119 NNS denotes Features
T8049 1120-1122 IN denotes in
T8050 1123-1131 JJ denotes Compound
T8052 1132-1144 JJ denotes Heterozygous
T8053 1145-1152 NN denotes Xpd TTD
T8055 1152-1153 HYPH denotes /
T8054 1153-1158 NN denotes †XPCS
T8051 1159-1163 NNS denotes Mice
T8056 1163-1264 sentence denotes (A) Photographs of 20-mo-old wt, compound heterozygous XpdTTD/†XPCS, and homozygous XpdTTD/TTD mice.
T8057 1164-1165 -LRB- denotes (
T8058 1165-1166 LS denotes A
T8060 1166-1167 -RRB- denotes )
T8059 1168-1179 NNS denotes Photographs
T8061 1180-1182 IN denotes of
T8062 1183-1185 CD denotes 20
T8064 1185-1186 HYPH denotes -
T8063 1186-1188 NN denotes mo
T8066 1188-1189 HYPH denotes -
T8065 1189-1192 JJ denotes old
T8068 1193-1195 NN denotes wt
T8069 1195-1197 , denotes ,
T8070 1197-1205 JJ denotes compound
T8072 1206-1218 JJ denotes heterozygous
T8073 1219-1225 NN denotes XpdTTD
T8074 1225-1226 HYPH denotes /
T8071 1226-1231 NN denotes †XPCS
T8075 1231-1233 , denotes ,
T8076 1233-1236 CC denotes and
T8077 1237-1247 JJ denotes homozygous
T8079 1248-1254 NN denotes XpdTTD
T8080 1254-1255 HYPH denotes /
T8078 1255-1258 NN denotes TTD
T8067 1259-1263 NNS denotes mice
T8081 1263-1264 . denotes .
T8082 1264-1404 sentence denotes Note the extreme cachexia (lack of subcutaneous fat) in the XpdTTD/TTD mouse and the absence of this phenotype in wt and XpdTTD/†XPCS mice.
T8083 1265-1269 VB denotes Note
T8084 1270-1273 DT denotes the
T8086 1274-1281 JJ denotes extreme
T8085 1282-1290 NN denotes cachexia
T8087 1291-1292 -LRB- denotes (
T8088 1292-1296 NN denotes lack
T8089 1297-1299 IN denotes of
T8090 1300-1312 JJ denotes subcutaneous
T8091 1313-1316 NN denotes fat
T8092 1316-1317 -RRB- denotes )
T8093 1318-1320 IN denotes in
T8094 1321-1324 DT denotes the
T8096 1325-1331 NN denotes XpdTTD
T8098 1331-1332 HYPH denotes /
T8097 1332-1335 NN denotes TTD
T8095 1336-1341 NN denotes mouse
T8099 1342-1345 CC denotes and
T8100 1346-1349 DT denotes the
T8101 1350-1357 NN denotes absence
T8102 1358-1360 IN denotes of
T8103 1361-1365 DT denotes this
T8104 1366-1375 NN denotes phenotype
T8105 1376-1378 IN denotes in
T8106 1379-1381 NN denotes wt
T8108 1382-1385 CC denotes and
T8109 1386-1392 NN denotes XpdTTD
T8111 1392-1393 HYPH denotes /
T8110 1393-1398 NN denotes †XPCS
T8107 1399-1403 NNS denotes mice
T8112 1403-1404 . denotes .
T8113 1404-1477 sentence denotes (B) Radiographs of 20-mo-old male wt, XpdTTD/†XPCS, and XpdTTD/TTD mice.
T8114 1405-1406 -LRB- denotes (
T8115 1406-1407 LS denotes B
T8117 1407-1408 -RRB- denotes )
T8116 1409-1420 NNS denotes Radiographs
T8118 1421-1423 IN denotes of
T8119 1424-1426 CD denotes 20
T8121 1426-1427 HYPH denotes -
T8120 1427-1429 NN denotes mo
T8123 1429-1430 HYPH denotes -
T8122 1430-1433 JJ denotes old
T8125 1434-1438 JJ denotes male
T8126 1439-1441 NN denotes wt
T8127 1441-1443 , denotes ,
T8128 1443-1449 NN denotes XpdTTD
T8130 1449-1450 HYPH denotes /
T8129 1450-1455 NN denotes †XPCS
T8131 1455-1457 , denotes ,
T8132 1457-1460 CC denotes and
T8133 1461-1467 NN denotes XpdTTD
T8135 1467-1468 HYPH denotes /
T8134 1468-1471 NN denotes TTD
T8124 1472-1476 NNS denotes mice
T8136 1476-1477 . denotes .
T8137 1477-1687 sentence denotes Ageing XpdTTD/TTD mice develop kyphosis (curvature of the spinal column) and reduction of bone mineral density as shown in the 6–8 segment of the tail vertebrae counted from the pelvis (see close-up at right).
T8138 1478-1484 VBG denotes Ageing
T8140 1485-1491 NN denotes XpdTTD
T8142 1491-1492 HYPH denotes /
T8141 1492-1495 NN denotes TTD
T8139 1496-1500 NNS denotes mice
T8143 1501-1508 VBP denotes develop
T8144 1509-1517 NN denotes kyphosis
T8145 1518-1519 -LRB- denotes (
T8146 1519-1528 NN denotes curvature
T8147 1529-1531 IN denotes of
T8148 1532-1535 DT denotes the
T8150 1536-1542 JJ denotes spinal
T8149 1543-1549 NN denotes column
T8151 1549-1550 -RRB- denotes )
T8152 1551-1554 CC denotes and
T8153 1555-1564 NN denotes reduction
T8154 1565-1567 IN denotes of
T8155 1568-1572 NN denotes bone
T8156 1573-1580 NN denotes mineral
T8157 1581-1588 NN denotes density
T8158 1589-1591 IN denotes as
T8159 1592-1597 VBN denotes shown
T8160 1598-1600 IN denotes in
T8161 1601-1604 DT denotes the
T8163 1605-1606 CD denotes 6
T8165 1606-1607 SYM denotes –
T8164 1607-1608 CD denotes 8
T8162 1609-1616 NN denotes segment
T8166 1617-1619 IN denotes of
T8167 1620-1623 DT denotes the
T8169 1624-1628 NN denotes tail
T8168 1629-1638 NNS denotes vertebrae
T8170 1639-1646 VBN denotes counted
T8171 1647-1651 IN denotes from
T8172 1652-1655 DT denotes the
T8173 1656-1662 NN denotes pelvis
T8174 1663-1664 -LRB- denotes (
T8175 1664-1667 VB denotes see
T8176 1668-1673 JJ denotes close
T8177 1673-1674 HYPH denotes -
T8178 1674-1676 RP denotes up
T8179 1677-1679 IN denotes at
T8180 1680-1685 NN denotes right
T8181 1685-1686 -RRB- denotes )
T8182 1686-1687 . denotes .
T8183 1687-1752 sentence denotes Note the absence of these features in the XpdTTD / † XPCS mouse.
T8184 1688-1692 VB denotes Note
T8185 1693-1696 DT denotes the
T8186 1697-1704 NN denotes absence
T8187 1705-1707 IN denotes of
T8188 1708-1713 DT denotes these
T8189 1714-1722 NNS denotes features
T8190 1723-1725 IN denotes in
T8191 1726-1729 DT denotes the
T8193 1730-1737 NN denotes XpdTTD 
T8195 1737-1738 HYPH denotes /
T8194 1738-1745 NN denotes  † XPCS
T8192 1746-1751 NN denotes mouse
T8196 1751-1752 . denotes .
T8197 1752-1905 sentence denotes (C) Quantification of relative bone mineral density of tail vertebrae from 20-mo-old male wt (n = 3), XpdTTD/†XPCS (n = 4), and XpdTTD/TTD (n = 3) mice.
T8198 1753-1754 -LRB- denotes (
T8199 1754-1755 LS denotes C
T8201 1755-1756 -RRB- denotes )
T8200 1757-1771 NN denotes Quantification
T8202 1772-1774 IN denotes of
T8203 1775-1783 JJ denotes relative
T8205 1784-1788 NN denotes bone
T8206 1789-1796 NN denotes mineral
T8204 1797-1804 NN denotes density
T8207 1805-1807 IN denotes of
T8208 1808-1812 NN denotes tail
T8209 1813-1822 NNS denotes vertebrae
T8210 1823-1827 IN denotes from
T8211 1828-1830 CD denotes 20
T8213 1830-1831 HYPH denotes -
T8212 1831-1833 NN denotes mo
T8215 1833-1834 HYPH denotes -
T8214 1834-1837 JJ denotes old
T8217 1838-1842 JJ denotes male
T8218 1843-1845 NN denotes wt
T8219 1846-1847 -LRB- denotes (
T8221 1847-1848 NN denotes n
T8222 1849-1850 SYM denotes =
T8220 1851-1852 CD denotes 3
T8223 1852-1853 -RRB- denotes )
T8224 1853-1855 , denotes ,
T8225 1855-1861 NN denotes XpdTTD
T8227 1861-1862 HYPH denotes /
T8226 1862-1867 NN denotes †XPCS
T8228 1868-1869 -LRB- denotes (
T8230 1869-1870 NN denotes n
T8231 1871-1872 SYM denotes =
T8229 1873-1874 CD denotes 4
T8232 1874-1875 -RRB- denotes )
T8233 1875-1877 , denotes ,
T8234 1877-1880 CC denotes and
T8235 1881-1887 NN denotes XpdTTD
T8237 1887-1888 HYPH denotes /
T8236 1888-1891 NN denotes TTD
T8238 1892-1893 -LRB- denotes (
T8240 1893-1894 NN denotes n
T8241 1895-1896 SYM denotes =
T8239 1897-1898 CD denotes 3
T8242 1898-1899 -RRB- denotes )
T8216 1900-1904 NNS denotes mice
T8243 1904-1905 . denotes .
T8244 1905-1986 sentence denotes The p-values indicate the significance of the difference relative to XpdTTD/TTD.
T8245 1906-1909 DT denotes The
T8247 1910-1911 NN denotes p
T8248 1911-1912 HYPH denotes -
T8246 1912-1918 NNS denotes values
T8249 1919-1927 VBP denotes indicate
T8250 1928-1931 DT denotes the
T8251 1932-1944 NN denotes significance
T8252 1945-1947 IN denotes of
T8253 1948-1951 DT denotes the
T8254 1952-1962 NN denotes difference
T8255 1963-1971 JJ denotes relative
T8256 1972-1974 IN denotes to
T8257 1975-1981 NN denotes XpdTTD
T8259 1981-1982 HYPH denotes /
T8258 1982-1985 NN denotes TTD
T8260 1985-1986 . denotes .
T8261 1986-2011 sentence denotes Error bars indicate SEM.
T8262 1987-1992 NN denotes Error
T8263 1993-1997 NNS denotes bars
T8264 1998-2006 VBP denotes indicate
T8265 2007-2010 NN denotes SEM
T8266 2010-2011 . denotes .
T8267 2011-2057 sentence denotes (D) Body weight curves as a function of time.
T8268 2012-2013 -LRB- denotes (
T8269 2013-2014 LS denotes D
T8271 2014-2015 -RRB- denotes )
T8272 2016-2020 NN denotes Body
T8273 2021-2027 NN denotes weight
T8270 2028-2034 NNS denotes curves
T8274 2035-2037 IN denotes as
T8275 2038-2039 DT denotes a
T8276 2040-2048 NN denotes function
T8277 2049-2051 IN denotes of
T8278 2052-2056 NN denotes time
T8279 2056-2057 . denotes .
T8280 2057-2179 sentence denotes Note that the age-dependent cachexia observed in XpdTTD/TTD mice was rescued in both male and female XpdTTD / †XPCS mice.
T8281 2058-2062 VB denotes Note
T8282 2063-2067 IN denotes that
T8284 2068-2071 DT denotes the
T8286 2072-2075 NN denotes age
T8288 2075-2076 HYPH denotes -
T8287 2076-2085 JJ denotes dependent
T8285 2086-2094 NN denotes cachexia
T8289 2095-2103 VBN denotes observed
T8290 2104-2106 IN denotes in
T8291 2107-2113 NN denotes XpdTTD
T8293 2113-2114 HYPH denotes /
T8292 2114-2117 NN denotes TTD
T8294 2118-2122 NNS denotes mice
T8295 2123-2126 VBD denotes was
T8283 2127-2134 VBN denotes rescued
T8296 2135-2137 IN denotes in
T8297 2138-2142 CC denotes both
T8298 2143-2147 JJ denotes male
T8300 2148-2151 CC denotes and
T8301 2152-2158 JJ denotes female
T8302 2159-2166 NN denotes XpdTTD 
T8304 2166-2167 HYPH denotes /
T8303 2167-2173 NN denotes  †XPCS
T8299 2174-2178 NNS denotes mice
T8305 2178-2179 . denotes .
T8306 2179-2333 sentence denotes Significant differences between wt and XpdTTD/TTD but not between wt and XpdTTD/†XPCS mice were observed at 9 and 18 mo of age as indicated by asterisks.
T8307 2180-2191 JJ denotes Significant
T8308 2192-2203 NNS denotes differences
T8310 2204-2211 IN denotes between
T8311 2212-2214 NN denotes wt
T8312 2215-2218 CC denotes and
T8313 2219-2225 NN denotes XpdTTD
T8315 2225-2226 HYPH denotes /
T8314 2226-2229 NN denotes TTD
T8316 2230-2233 CC denotes but
T8317 2234-2237 RB denotes not
T8318 2238-2245 IN denotes between
T8319 2246-2248 NN denotes wt
T8321 2249-2252 CC denotes and
T8322 2253-2259 NN denotes XpdTTD
T8324 2259-2260 HYPH denotes /
T8323 2260-2265 NN denotes †XPCS
T8320 2266-2270 NNS denotes mice
T8325 2271-2275 VBD denotes were
T8309 2276-2284 VBN denotes observed
T8326 2285-2287 IN denotes at
T8327 2288-2289 CD denotes 9
T8329 2290-2293 CC denotes and
T8330 2294-2296 CD denotes 18
T8328 2297-2299 NNS denotes mo
T8331 2300-2302 IN denotes of
T8332 2303-2306 NN denotes age
T8333 2307-2309 IN denotes as
T8334 2310-2319 VBN denotes indicated
T8335 2320-2322 IN denotes by
T8336 2323-2332 NNS denotes asterisks
T8337 2332-2333 . denotes .
T8338 2333-2358 sentence denotes Error bars indicate SEM.
T8339 2334-2339 NN denotes Error
T8340 2340-2344 NNS denotes bars
T8341 2345-2353 VBP denotes indicate
T8342 2354-2357 NN denotes SEM
T8343 2357-2358 . denotes .
T9241 2368-2379 JJ denotes Pleiotropic
T9243 2380-2383 NN denotes Xpd
T9244 2384-2393 JJ denotes Biallelic
T9242 2394-2401 NNS denotes Effects
T9245 2402-2404 IN denotes in
T9246 2405-2409 NNS denotes Mice
T9247 2410-2413 CC denotes and
T9248 2414-2419 NNS denotes Cells
T2792 2420-2422 TO denotes To
T2793 2423-2432 VB denotes determine
T2795 2433-2440 IN denotes whether
T2797 2441-2444 DT denotes the
T2799 2445-2455 JJ denotes homozygous
T2800 2456-2462 JJ denotes lethal
T2801 2463-2471 NN denotes Xpd†XPCS
T2798 2472-2478 NN denotes allele
T2796 2479-2482 VBD denotes was
T2802 2483-2489 JJ denotes unique
T2803 2490-2492 IN denotes in
T2804 2493-2496 PRP$ denotes its
T2805 2497-2504 NN denotes ability
T2806 2505-2507 TO denotes to
T2807 2508-2518 VB denotes ameliorate
T2808 2519-2527 NNS denotes symptoms
T2809 2528-2538 VBN denotes associated
T2810 2539-2543 IN denotes with
T2811 2544-2547 DT denotes the
T2813 2548-2554 NN denotes XpdTTD
T2812 2555-2561 NN denotes allele
T2814 2561-2563 , denotes ,
T2815 2563-2565 PRP denotes we
T2794 2566-2575 VBD denotes generated
T2816 2576-2584 NN denotes compound
T2818 2585-2597 JJ denotes heterozygous
T2819 2598-2604 NN denotes XpdTTD
T2821 2604-2605 HYPH denotes /
T2820 2605-2608 NN denotes †XP
T2817 2609-2613 NNS denotes mice
T2822 2614-2616 IN denotes by
T2823 2617-2625 VBG denotes crossing
T2824 2626-2629 DT denotes the
T2826 2630-2643 VBG denotes corresponding
T2827 2644-2656 JJ denotes heterozygous
T2825 2657-2664 NNS denotes animals
T2828 2664-2665 . denotes .
T2829 2665-3111 sentence denotes Similar to the Xpd †XPCS allele, the homozygous lethal Xpd †XP allele rescued cutaneous symptoms including hair loss (except locally during the first round; unpublished data), reduced cysteine content (cysteine index 9.3 ± 0.9 standard deviation [87% of wt], p = 0.01 versus TTD), ageing-associated premature cachexia (males and females were 36.1 ± 6.4 g [93% of wt] and 39.2 ± 3.2 g [116% of wt], respectively), and reduced life span (Table 2).
T2830 2666-2673 JJ denotes Similar
T2832 2674-2676 IN denotes to
T2833 2677-2680 DT denotes the
T2835 2681-2690 NN denotes Xpd †XPCS
T2834 2691-2697 NN denotes allele
T2836 2697-2699 , denotes ,
T2837 2699-2702 DT denotes the
T2839 2703-2713 JJ denotes homozygous
T2840 2714-2720 JJ denotes lethal
T2841 2721-2728 NN denotes Xpd †XP
T2838 2729-2735 NN denotes allele
T2831 2736-2743 VBD denotes rescued
T2842 2744-2753 JJ denotes cutaneous
T2843 2754-2762 NNS denotes symptoms
T2844 2763-2772 VBG denotes including
T2845 2773-2777 NN denotes hair
T2846 2778-2782 NN denotes loss
T2847 2783-2784 -LRB- denotes (
T2849 2784-2790 IN denotes except
T2850 2791-2798 RB denotes locally
T2851 2799-2805 IN denotes during
T2852 2806-2809 DT denotes the
T2854 2810-2815 JJ denotes first
T2853 2816-2821 NN denotes round
T2855 2821-2822 : denotes ;
T2856 2823-2834 JJ denotes unpublished
T2848 2835-2839 NNS denotes data
T2857 2839-2840 -RRB- denotes )
T2858 2840-2842 , denotes ,
T2859 2842-2849 VBN denotes reduced
T2861 2850-2858 NN denotes cysteine
T2860 2859-2866 NN denotes content
T2862 2867-2868 -LRB- denotes (
T2864 2868-2876 NN denotes cysteine
T2863 2877-2882 NN denotes index
T2865 2883-2886 CD denotes 9.3
T2866 2887-2888 SYM denotes ±
T2867 2889-2892 CD denotes 0.9
T2869 2893-2901 JJ denotes standard
T2868 2902-2911 NN denotes deviation
T2870 2912-2913 -LRB- denotes [
T2872 2913-2915 CD denotes 87
T2871 2915-2916 NN denotes %
T2873 2917-2919 IN denotes of
T2874 2920-2922 NN denotes wt
T2875 2922-2923 -RRB- denotes ]
T2876 2923-2925 , denotes ,
T2877 2925-2926 NN denotes p
T2879 2927-2928 SYM denotes =
T2880 2929-2933 CD denotes 0.01
T2881 2934-2940 CC denotes versus
T2878 2941-2944 NN denotes TTD
T2882 2944-2945 -RRB- denotes )
T2883 2945-2947 , denotes ,
T2884 2947-2953 NN denotes ageing
T2886 2953-2954 HYPH denotes -
T2885 2954-2964 VBN denotes associated
T2888 2965-2974 JJ denotes premature
T2887 2975-2983 NN denotes cachexia
T2889 2984-2985 -LRB- denotes (
T2891 2985-2990 NNS denotes males
T2892 2991-2994 CC denotes and
T2893 2995-3002 NNS denotes females
T2890 3003-3007 VBD denotes were
T2894 3008-3012 CD denotes 36.1
T2896 3013-3014 SYM denotes ±
T2895 3015-3018 CD denotes 6.4
T2897 3019-3020 NNS denotes g
T2898 3021-3022 -LRB- denotes [
T2900 3022-3024 CD denotes 93
T2899 3024-3025 NN denotes %
T2901 3026-3028 IN denotes of
T2902 3029-3031 NN denotes wt
T2903 3031-3032 -RRB- denotes ]
T2904 3033-3036 CC denotes and
T2905 3037-3041 CD denotes 39.2
T2907 3042-3043 SYM denotes ±
T2906 3044-3047 CD denotes 3.2
T2908 3048-3049 NNS denotes g
T2909 3050-3051 -LRB- denotes [
T2911 3051-3054 CD denotes 116
T2910 3054-3055 NN denotes %
T2912 3056-3058 IN denotes of
T2913 3059-3061 NN denotes wt
T2914 3061-3062 -RRB- denotes ]
T2915 3062-3064 , denotes ,
T2916 3064-3076 RB denotes respectively
T2917 3076-3077 -RRB- denotes )
T2918 3077-3079 , denotes ,
T2919 3079-3082 CC denotes and
T2920 3083-3090 VBN denotes reduced
T2922 3091-3095 NN denotes life
T2921 3096-3100 NN denotes span
T2923 3101-3102 -LRB- denotes (
T2924 3102-3107 NN denotes Table
T2925 3108-3109 CD denotes 2
T2926 3109-3110 -RRB- denotes )
T2927 3110-3111 . denotes .
T2928 3111-3320 sentence denotes Taken together, these data indicate that two independent alleles, which on their own are unable to support viability (Table 1), were nonetheless able to ameliorate TTD-associated phenotypes in vivo (Table 2).
T2929 3112-3117 VBN denotes Taken
T2931 3118-3126 RB denotes together
T2932 3126-3128 , denotes ,
T2933 3128-3133 DT denotes these
T2934 3134-3138 NNS denotes data
T2930 3139-3147 VBP denotes indicate
T2935 3148-3152 IN denotes that
T2937 3153-3156 CD denotes two
T2939 3157-3168 JJ denotes independent
T2938 3169-3176 NNS denotes alleles
T2940 3176-3178 , denotes ,
T2941 3178-3183 WDT denotes which
T2943 3184-3186 IN denotes on
T2944 3187-3192 PRP$ denotes their
T2945 3193-3196 NN denotes own
T2942 3197-3200 VBP denotes are
T2946 3201-3207 JJ denotes unable
T2947 3208-3210 TO denotes to
T2948 3211-3218 VB denotes support
T2949 3219-3228 NN denotes viability
T2950 3229-3230 -LRB- denotes (
T2951 3230-3235 NN denotes Table
T2952 3236-3237 CD denotes 1
T2953 3237-3238 -RRB- denotes )
T2954 3238-3240 , denotes ,
T2936 3240-3244 VBD denotes were
T2955 3245-3256 RB denotes nonetheless
T2956 3257-3261 JJ denotes able
T2957 3262-3264 TO denotes to
T2958 3265-3275 VB denotes ameliorate
T2959 3276-3279 NN denotes TTD
T2961 3279-3280 HYPH denotes -
T2960 3280-3290 VBN denotes associated
T2962 3291-3301 NNS denotes phenotypes
T2963 3302-3304 FW denotes in
T2964 3305-3309 FW denotes vivo
T2965 3310-3311 -LRB- denotes (
T2966 3311-3316 NN denotes Table
T2967 3317-3318 CD denotes 2
T2968 3318-3319 -RRB- denotes )
T2969 3319-3320 . denotes .
R1706 T2577 T2578 compound TTD,Mice
R1707 T2578 T2576 pobj Mice,in
R1709 T2580 T2581 amod Homozygous,Alleles
R1710 T2581 T2579 pobj Alleles,by
R1711 T2582 T2581 amod Lethal,Alleles
R1712 T2583 T2581 compound Xpd,Alleles
R1713 T2585 T2586 mark Because,share
R1714 T2586 T2605 advcl share,addressed
R1715 T2587 T2586 nsubj patients,share
R1716 T2588 T2587 prep with,patients
R1717 T2589 T2588 pobj TTD,with
R1718 T2590 T2589 punct ", ",TTD
R1719 T2591 T2589 conj XPCS,TTD
R1720 T2592 T2591 punct ", ",XPCS
R1721 T2593 T2591 cc and,XPCS
R1722 T2594 T2591 conj CS,XPCS
R1723 T2595 T2589 punct (,TTD
R1724 T2596 T2589 cc but,TTD
R1725 T2597 T2596 neg not,but
R1726 T2598 T2589 conj XP,TTD
R1727 T2599 T2587 punct ),patients
R1728 T2600 T2587 cc and,patients
R1729 T2601 T2602 det the,models
R1730 T2602 T2587 conj models,patients
R1731 T2603 T2602 amod corresponding,models
R1732 T2604 T2602 compound mouse,models
R1733 T2606 T2607 amod similar,symptoms
R1734 T2607 T2586 dobj symptoms,share
R1735 T2608 T2607 amod accelerated,symptoms
R1736 T2609 T2607 compound progeroid,symptoms
R1737 T2610 T2611 punct [,23
R1738 T2611 T2586 parataxis 23,share
R1739 T2612 T2611 nummod 12,23
R1740 T2613 T2611 punct ",",23
R1741 T2614 T2611 nummod 13,23
R1742 T2615 T2611 punct ",",23
R1743 T2616 T2611 nummod 15,23
R1744 T2617 T2611 punct ",",23
R1745 T2618 T2611 punct ],23
R1746 T2619 T2605 punct ", ",addressed
R1747 T2620 T2605 nsubj we,addressed
R1748 T2621 T2605 advmod next,addressed
R1749 T2622 T2623 amod ageing,related
R1750 T2623 T2625 amod related,parameters
R1751 T2624 T2623 punct -,related
R1752 T2625 T2605 dobj parameters,addressed
R1753 T2626 T2625 prep in,parameters
R1754 T2627 T2628 amod compound,mice
R1755 T2628 T2626 pobj mice,in
R1756 T2629 T2628 amod heterozygous,mice
R1757 T2630 T2631 punct (,Figure
R1758 T2631 T2605 parataxis Figure,addressed
R1759 T2632 T2631 nummod 3,Figure
R1760 T2633 T2631 punct ),Figure
R1761 T2634 T2605 punct .,addressed
R1762 T2636 T2637 mark Whereas,show
R1763 T2637 T2642 advcl show,were
R1764 T2638 T2639 compound XpdTTD,TTD
R1765 T2639 T2641 compound TTD,animals
R1766 T2640 T2639 punct /,TTD
R1767 T2641 T2637 nsubj animals,show
R1768 T2643 T2644 amod reduced,density
R1769 T2644 T2637 dobj density,show
R1770 T2645 T2646 compound bone,mineral
R1771 T2646 T2644 compound mineral,density
R1772 T2647 T2637 prep as,show
R1773 T2648 T2649 det an,indication
R1774 T2649 T2647 pobj indication,as
R1775 T2650 T2649 prep of,indication
R1776 T2651 T2652 det the,onset
R1777 T2652 T2650 pobj onset,of
R1778 T2653 T2652 amod early,onset
R1779 T2654 T2652 prep of,onset
R1780 T2655 T2654 pobj osteoporosis,of
R1781 T2656 T2652 prep before,onset
R1782 T2657 T2658 punct ~,14
R1783 T2658 T2659 nummod 14,mo
R1784 T2659 T2656 pobj mo,before
R1785 T2660 T2659 prep of,mo
R1786 T2661 T2660 pobj age,of
R1787 T2662 T2663 punct [,15
R1788 T2663 T2637 parataxis 15,show
R1789 T2664 T2663 punct ],15
R1790 T2665 T2642 punct ", ",were
R1791 T2666 T2667 compound tail,vertebrae
R1792 T2667 T2642 nsubj vertebrae,were
R1793 T2668 T2667 prep from,vertebrae
R1794 T2669 T2670 nmod compound,mice
R1795 T2670 T2668 pobj mice,from
R1796 T2671 T2670 amod heterozygous,mice
R1797 T2672 T2673 compound XpdTTD,†XPCS
R1798 T2673 T2670 compound †XPCS,mice
R1799 T2674 T2673 punct /,†XPCS
R1800 T2675 T2642 acomp comparable,were
R1801 T2676 T2675 prep to,comparable
R1802 T2677 T2676 pobj wt,to
R1803 T2678 T2679 advmod even,at
R1804 T2679 T2642 prep at,were
R1805 T2680 T2681 nummod 20,mo
R1806 T2681 T2679 pobj mo,at
R1807 T2682 T2681 prep of,mo
R1808 T2683 T2682 pobj age,of
R1809 T2684 T2685 punct (,3B
R1810 T2685 T2642 parataxis 3B,were
R1811 T2686 T2685 compound Figure,3B
R1812 T2687 T2685 cc and,3B
R1813 T2688 T2685 conj 3C,3B
R1814 T2689 T2685 punct ),3B
R1815 T2690 T2642 punct .,were
R1816 T2692 T2693 advmod Furthermore,3B
R1817 T2694 T2693 punct ", ",3B
R1818 T2695 T2696 mark whereas,developed
R1819 T2696 T2693 advcl developed,3B
R1820 T2697 T2698 compound XpdTTD,TTD
R1821 T2698 T2700 compound TTD,mice
R1822 T2699 T2698 punct /,TTD
R1823 T2700 T2696 nsubj mice,developed
R1824 T2701 T2696 dobj kyphosis,developed
R1825 T2702 T2696 advmod earlier,developed
R1826 T2703 T2702 prep than,earlier
R1827 T2704 T2705 compound wt,animals
R1828 T2705 T2703 pobj animals,than
R1829 T2706 T2707 punct (,onset
R1830 T2707 T2702 parataxis onset,earlier
R1831 T2708 T2709 punct ~,3
R1832 T2709 T2710 nummod 3,mo
R1833 T2710 T2707 npadvmod mo,onset
R1834 T2711 T2710 cc versus,mo
R1835 T2712 T2713 quantmod 12,20
R1836 T2713 T2715 nummod 20,mo
R1837 T2714 T2713 punct –,20
R1838 T2715 T2710 conj mo,mo
R1839 T2716 T2707 punct ),onset
R1840 T2717 T2693 punct ", ",3B
R1841 T2718 T2719 amod compound,mice
R1842 T2719 T2693 nsubj mice,3B
R1843 T2720 T2719 amod heterozygous,mice
R1844 T2721 T2722 compound XpdTTD,†XPCS
R1845 T2722 T2719 compound †XPCS,mice
R1846 T2723 T2722 punct /,†XPCS
R1847 T2724 T2693 aux did,3B
R1848 T2725 T2693 neg not,3B
R1849 T2726 T2693 punct (,3B
R1850 T2727 T2693 compound Figure,3B
R1851 T2728 T2693 punct ),3B
R1852 T2729 T2693 punct .,3B
R1853 T2731 T2732 amod Overall,appearance
R1854 T2732 T2733 nsubj appearance,revealed
R1855 T2734 T2732 cc and,appearance
R1856 T2735 T2736 compound body,weight
R1857 T2736 T2737 compound weight,curves
R1858 T2737 T2732 conj curves,appearance
R1859 T2738 T2739 mark that,rescued
R1860 T2739 T2733 ccomp rescued,revealed
R1861 T2740 T2741 npadvmod TTD,associated
R1862 T2741 T2743 amod associated,cachexia
R1863 T2742 T2741 punct -,associated
R1864 T2743 T2739 nsubjpass cachexia,rescued
R1865 T2744 T2745 npadvmod age,related
R1866 T2745 T2743 amod related,cachexia
R1867 T2746 T2745 punct -,related
R1868 T2747 T2743 amod premature,cachexia
R1869 T2748 T2743 cc and,cachexia
R1870 T2749 T2743 conj lack,cachexia
R1871 T2750 T2749 prep of,lack
R1872 T2751 T2752 amod general,fitness
R1873 T2752 T2750 pobj fitness,of
R1874 T2753 T2739 auxpass were,rescued
R1875 T2754 T2739 advmod fully,rescued
R1876 T2755 T2739 prep in,rescued
R1877 T2756 T2757 amod compound,mice
R1878 T2757 T2755 pobj mice,in
R1879 T2758 T2757 amod heterozygous,mice
R1880 T2759 T2760 compound XpdTTD,†XPCS
R1881 T2760 T2757 compound †XPCS,mice
R1882 T2761 T2760 punct /,†XPCS
R1883 T2762 T2763 punct (,3A
R1884 T2763 T2733 parataxis 3A,revealed
R1885 T2764 T2763 compound Figure,3A
R1886 T2765 T2763 cc and,3A
R1887 T2766 T2763 conj 3D,3A
R1888 T2767 T2763 punct ),3A
R1889 T2768 T2733 punct .,revealed
R1890 T2770 T2771 advmod Finally,extended
R1891 T2772 T2771 punct ", ",extended
R1892 T2773 T2774 det the,span
R1893 T2774 T2771 nsubjpass span,extended
R1894 T2775 T2774 compound life,span
R1895 T2776 T2774 prep of,span
R1896 T2777 T2778 amod compound,heterozygotes
R1897 T2778 T2776 pobj heterozygotes,of
R1898 T2779 T2771 auxpass was,extended
R1899 T2780 T2771 advcl relative,extended
R1900 T2781 T2780 prep to,relative
R1901 T2782 T2783 compound XpdTTD,TTD
R1902 T2783 T2785 compound TTD,mice
R1903 T2784 T2783 punct /,TTD
R1904 T2785 T2781 pobj mice,to
R1905 T2786 T2787 punct (,Table
R1906 T2787 T2771 parataxis Table,extended
R1907 T2788 T2787 nummod 2,Table
R1908 T2789 T2787 punct ),Table
R1909 T2790 T2771 punct .,extended
R1910 T2792 T2793 aux To,determine
R1911 T2793 T2794 advcl determine,generated
R1912 T2795 T2796 mark whether,was
R1913 T2796 T2793 ccomp was,determine
R1914 T2797 T2798 det the,allele
R1915 T2798 T2796 nsubj allele,was
R1916 T2799 T2798 amod homozygous,allele
R1917 T2800 T2798 amod lethal,allele
R1918 T2801 T2798 compound Xpd†XPCS,allele
R1919 T2802 T2796 acomp unique,was
R1920 T2803 T2802 prep in,unique
R1921 T2804 T2805 poss its,ability
R1922 T2805 T2803 pobj ability,in
R1923 T2806 T2807 aux to,ameliorate
R1924 T2807 T2805 acl ameliorate,ability
R1925 T2808 T2807 dobj symptoms,ameliorate
R1926 T2809 T2808 acl associated,symptoms
R1927 T2810 T2809 prep with,associated
R1928 T2811 T2812 det the,allele
R1929 T2812 T2810 pobj allele,with
R1930 T2813 T2812 compound XpdTTD,allele
R1931 T2814 T2794 punct ", ",generated
R1932 T2815 T2794 nsubj we,generated
R1933 T2816 T2817 nmod compound,mice
R1934 T2817 T2794 dobj mice,generated
R1935 T2818 T2817 amod heterozygous,mice
R1936 T2819 T2820 compound XpdTTD,†XP
R1937 T2820 T2817 compound †XP,mice
R1938 T2821 T2820 punct /,†XP
R1939 T2822 T2794 prep by,generated
R1940 T2823 T2822 pcomp crossing,by
R1941 T2824 T2825 det the,animals
R1942 T2825 T2823 dobj animals,crossing
R1943 T2826 T2825 amod corresponding,animals
R1944 T2827 T2825 amod heterozygous,animals
R1945 T2828 T2794 punct .,generated
R1946 T2830 T2831 advcl Similar,rescued
R1947 T2832 T2830 prep to,Similar
R1948 T2833 T2834 det the,allele
R1949 T2834 T2832 pobj allele,to
R1950 T2835 T2834 compound Xpd †XPCS,allele
R1951 T2836 T2831 punct ", ",rescued
R1952 T2837 T2838 det the,allele
R1953 T2838 T2831 nsubj allele,rescued
R1954 T2839 T2838 amod homozygous,allele
R1955 T2840 T2838 amod lethal,allele
R1956 T2841 T2838 compound Xpd †XP,allele
R1957 T2842 T2843 amod cutaneous,symptoms
R1958 T2843 T2831 dobj symptoms,rescued
R1959 T2844 T2843 prep including,symptoms
R1960 T2845 T2846 compound hair,loss
R1961 T2846 T2844 pobj loss,including
R1962 T2847 T2848 punct (,data
R1963 T2848 T2846 parataxis data,loss
R1964 T2849 T2848 prep except,data
R1965 T2850 T2849 pcomp locally,except
R1966 T2851 T2850 prep during,locally
R1967 T2852 T2853 det the,round
R1968 T2853 T2851 pobj round,during
R1969 T2854 T2853 amod first,round
R1970 T2855 T2848 punct ;,data
R1971 T2856 T2848 amod unpublished,data
R1972 T2857 T2848 punct ),data
R1973 T2858 T2846 punct ", ",loss
R1974 T2859 T2860 amod reduced,content
R1975 T2860 T2846 conj content,loss
R1976 T2861 T2860 compound cysteine,content
R1977 T2862 T2863 punct (,index
R1978 T2863 T2860 parataxis index,content
R1979 T2864 T2863 compound cysteine,index
R1980 T2865 T2863 npadvmod 9.3,index
R1981 T2866 T2865 punct ±,9.3
R1982 T2867 T2868 nummod 0.9,deviation
R1983 T2868 T2865 appos deviation,9.3
R1984 T2869 T2868 amod standard,deviation
R1985 T2870 T2871 punct [,%
R1986 T2871 T2865 parataxis %,9.3
R1987 T2872 T2871 nummod 87,%
R1988 T2873 T2871 prep of,%
R1989 T2874 T2873 pobj wt,of
R1990 T2875 T2871 punct ],%
R1991 T2876 T2863 punct ", ",index
R1992 T2877 T2878 nsubj p,TTD
R1993 T2878 T2863 ccomp TTD,index
R1994 T2879 T2878 punct =,TTD
R1995 T2880 T2878 nummod 0.01,TTD
R1996 T2881 T2878 cc versus,TTD
R1997 T2882 T2863 punct ),index
R1998 T2883 T2860 punct ", ",content
R1999 T2884 T2885 npadvmod ageing,associated
R2000 T2885 T2887 amod associated,cachexia
R2001 T2886 T2885 punct -,associated
R2002 T2887 T2860 conj cachexia,content
R2003 T2888 T2887 amod premature,cachexia
R2004 T2889 T2890 punct (,were
R2005 T2890 T2887 parataxis were,cachexia
R2006 T2891 T2890 nsubj males,were
R2007 T2892 T2891 cc and,males
R2008 T2893 T2891 conj females,males
R2009 T2894 T2895 nummod 36.1,6.4
R2010 T2895 T2897 nummod 6.4,g
R2011 T2896 T2895 punct ±,6.4
R2012 T2897 T2890 attr g,were
R2013 T2898 T2899 punct [,%
R2014 T2899 T2897 parataxis %,g
R2015 T2900 T2899 nummod 93,%
R2016 T2901 T2899 prep of,%
R2017 T2902 T2901 pobj wt,of
R2018 T2903 T2899 punct ],%
R2019 T2904 T2897 cc and,g
R2020 T2905 T2906 nummod 39.2,3.2
R2021 T2906 T2908 nummod 3.2,g
R2022 T2907 T2906 punct ±,3.2
R2023 T2908 T2897 conj g,g
R2024 T2909 T2910 punct [,%
R2025 T2910 T2908 parataxis %,g
R2026 T2911 T2910 nummod 116,%
R2027 T2912 T2910 prep of,%
R2028 T2913 T2912 pobj wt,of
R2029 T2914 T2910 punct ],%
R2030 T2915 T2890 punct ", ",were
R2031 T2916 T2890 advmod respectively,were
R2032 T2917 T2890 punct ),were
R2033 T2918 T2887 punct ", ",cachexia
R2034 T2919 T2887 cc and,cachexia
R2035 T2920 T2921 amod reduced,span
R2036 T2921 T2887 conj span,cachexia
R2037 T2922 T2921 compound life,span
R2038 T2923 T2924 punct (,Table
R2039 T2924 T2831 parataxis Table,rescued
R2040 T2925 T2924 nummod 2,Table
R2041 T2926 T2924 punct ),Table
R2042 T2927 T2831 punct .,rescued
R2043 T2929 T2930 advcl Taken,indicate
R2044 T2931 T2929 advmod together,Taken
R2045 T2932 T2930 punct ", ",indicate
R2046 T2933 T2934 det these,data
R2047 T2934 T2930 nsubj data,indicate
R2048 T2935 T2936 mark that,were
R2049 T2936 T2930 ccomp were,indicate
R2050 T2937 T2938 nummod two,alleles
R2051 T2938 T2936 nsubj alleles,were
R2052 T2939 T2938 amod independent,alleles
R2053 T2940 T2938 punct ", ",alleles
R2054 T2941 T2942 dep which,are
R2055 T2942 T2938 relcl are,alleles
R2056 T2943 T2942 prep on,are
R2057 T2944 T2945 poss their,own
R2058 T2945 T2943 pobj own,on
R2059 T2946 T2942 acomp unable,are
R2060 T2947 T2948 aux to,support
R2061 T2948 T2946 xcomp support,unable
R2062 T2949 T2948 dobj viability,support
R2063 T2950 T2951 punct (,Table
R2064 T2951 T2948 parataxis Table,support
R2065 T2952 T2951 nummod 1,Table
R2066 T2953 T2951 punct ),Table
R2067 T2954 T2936 punct ", ",were
R2068 T2955 T2936 advmod nonetheless,were
R2069 T2956 T2936 acomp able,were
R2070 T2957 T2958 aux to,ameliorate
R2071 T2958 T2956 xcomp ameliorate,able
R2072 T2959 T2960 npadvmod TTD,associated
R2073 T2960 T2962 amod associated,phenotypes
R2074 T2961 T2960 punct -,associated
R2075 T2962 T2958 dobj phenotypes,ameliorate
R2076 T2963 T2964 advmod in,vivo
R2077 T2964 T2958 advmod vivo,ameliorate
R2078 T2965 T2966 punct (,Table
R2079 T2966 T2958 parataxis Table,ameliorate
R2080 T2967 T2966 nummod 2,Table
R2081 T2968 T2966 punct ),Table
R2082 T2969 T2930 punct .,indicate
R5429 T8042 T8041 prep of,Rescue
R5430 T8043 T8044 npadvmod TTD,Associated
R5431 T8044 T8046 amod Associated,Features
R5432 T8045 T8044 punct -,Associated
R5433 T8046 T8042 pobj Features,of
R5434 T8047 T8046 amod Segmental,Features
R5435 T8048 T8046 amod Progeroid,Features
R5436 T8049 T8046 prep in,Features
R5437 T8050 T8051 amod Compound,Mice
R5438 T8051 T8049 pobj Mice,in
R5439 T8052 T8051 amod Heterozygous,Mice
R5440 T8053 T8054 compound Xpd TTD,†XPCS
R5441 T8054 T8051 compound †XPCS,Mice
R5442 T8055 T8054 punct /,†XPCS
R5443 T8057 T8058 punct (,A
R5444 T8058 T8059 meta A,Photographs
R5445 T8060 T8058 punct ),A
R5446 T8061 T8059 prep of,Photographs
R5447 T8062 T8063 nummod 20,mo
R5448 T8063 T8065 npadvmod mo,old
R5449 T8064 T8063 punct -,mo
R5450 T8065 T8067 amod old,mice
R5451 T8066 T8065 punct -,old
R5452 T8067 T8061 pobj mice,of
R5453 T8068 T8067 nmod wt,mice
R5454 T8069 T8068 punct ", ",wt
R5455 T8070 T8071 amod compound,†XPCS
R5456 T8071 T8068 conj †XPCS,wt
R5457 T8072 T8071 amod heterozygous,†XPCS
R5458 T8073 T8071 compound XpdTTD,†XPCS
R5459 T8074 T8071 punct /,†XPCS
R5460 T8075 T8071 punct ", ",†XPCS
R5461 T8076 T8071 cc and,†XPCS
R5462 T8077 T8078 amod homozygous,TTD
R5463 T8078 T8071 conj TTD,†XPCS
R5464 T8079 T8078 compound XpdTTD,TTD
R5465 T8080 T8078 punct /,TTD
R5466 T8081 T8059 punct .,Photographs
R5467 T8084 T8085 det the,cachexia
R5468 T8085 T8083 dobj cachexia,Note
R5469 T8086 T8085 amod extreme,cachexia
R5470 T8087 T8085 punct (,cachexia
R5471 T8088 T8085 appos lack,cachexia
R5472 T8089 T8088 prep of,lack
R5473 T8090 T8091 amod subcutaneous,fat
R5474 T8091 T8089 pobj fat,of
R5475 T8092 T8085 punct ),cachexia
R5476 T8093 T8085 prep in,cachexia
R5477 T8094 T8095 det the,mouse
R5478 T8095 T8093 pobj mouse,in
R5479 T8096 T8097 compound XpdTTD,TTD
R5480 T8097 T8095 compound TTD,mouse
R5481 T8098 T8097 punct /,TTD
R5482 T8099 T8083 cc and,Note
R5483 T8100 T8101 det the,absence
R5484 T8101 T8083 conj absence,Note
R5485 T8102 T8101 prep of,absence
R5486 T8103 T8104 det this,phenotype
R5487 T8104 T8102 pobj phenotype,of
R5488 T8105 T8101 prep in,absence
R5489 T8106 T8107 nmod wt,mice
R5490 T8107 T8105 pobj mice,in
R5491 T8108 T8106 cc and,wt
R5492 T8109 T8110 compound XpdTTD,†XPCS
R5493 T8110 T8106 conj †XPCS,wt
R5494 T8111 T8110 punct /,†XPCS
R5495 T8112 T8083 punct .,Note
R5496 T8114 T8115 punct (,B
R5497 T8115 T8116 meta B,Radiographs
R5498 T8117 T8115 punct ),B
R5499 T8118 T8116 prep of,Radiographs
R5500 T8119 T8120 nummod 20,mo
R5501 T8120 T8122 npadvmod mo,old
R5502 T8121 T8120 punct -,mo
R5503 T8122 T8124 amod old,mice
R5504 T8123 T8122 punct -,old
R5505 T8124 T8118 pobj mice,of
R5506 T8125 T8124 amod male,mice
R5507 T8126 T8124 nmod wt,mice
R5508 T8127 T8126 punct ", ",wt
R5509 T8128 T8129 compound XpdTTD,†XPCS
R5510 T8129 T8126 conj †XPCS,wt
R5511 T8130 T8129 punct /,†XPCS
R5512 T8131 T8129 punct ", ",†XPCS
R5513 T8132 T8129 cc and,†XPCS
R5514 T8133 T8134 compound XpdTTD,TTD
R5515 T8134 T8129 conj TTD,†XPCS
R5516 T8135 T8134 punct /,TTD
R5517 T8136 T8116 punct .,Radiographs
R5518 T8138 T8139 amod Ageing,mice
R5519 T8139 T8143 nsubj mice,develop
R5520 T8140 T8141 compound XpdTTD,TTD
R5521 T8141 T8139 compound TTD,mice
R5522 T8142 T8141 punct /,TTD
R5523 T8144 T8143 dobj kyphosis,develop
R5524 T8145 T8144 punct (,kyphosis
R5525 T8146 T8144 appos curvature,kyphosis
R5526 T8147 T8146 prep of,curvature
R5527 T8148 T8149 det the,column
R5528 T8149 T8147 pobj column,of
R5529 T8150 T8149 amod spinal,column
R5530 T8151 T8144 punct ),kyphosis
R5531 T8152 T8144 cc and,kyphosis
R5532 T8153 T8144 conj reduction,kyphosis
R5533 T8154 T8153 prep of,reduction
R5534 T8155 T8156 compound bone,mineral
R5535 T8156 T8157 compound mineral,density
R5536 T8157 T8154 pobj density,of
R5537 T8158 T8159 mark as,shown
R5538 T8159 T8143 advcl shown,develop
R5539 T8160 T8159 prep in,shown
R5540 T8161 T8162 det the,segment
R5541 T8162 T8160 pobj segment,in
R5542 T8163 T8164 quantmod 6,8
R5543 T8164 T8162 nummod 8,segment
R5544 T8165 T8164 punct –,8
R5545 T8166 T8162 prep of,segment
R5546 T8167 T8168 det the,vertebrae
R5547 T8168 T8166 pobj vertebrae,of
R5548 T8169 T8168 compound tail,vertebrae
R5549 T8170 T8162 acl counted,segment
R5550 T8171 T8170 prep from,counted
R5551 T8172 T8173 det the,pelvis
R5552 T8173 T8171 pobj pelvis,from
R5553 T8174 T8175 punct (,see
R5554 T8175 T8143 parataxis see,develop
R5555 T8176 T8175 dobj close,see
R5556 T8177 T8176 punct -,close
R5557 T8178 T8176 prt up,close
R5558 T8179 T8176 prep at,close
R5559 T8180 T8179 pobj right,at
R5560 T8181 T8175 punct ),see
R5561 T8182 T8143 punct .,develop
R5562 T8185 T8186 det the,absence
R5563 T8186 T8184 dobj absence,Note
R5564 T8187 T8186 prep of,absence
R5565 T8188 T8189 det these,features
R5566 T8189 T8187 pobj features,of
R5567 T8190 T8186 prep in,absence
R5568 T8191 T8192 det the,mouse
R5569 T8192 T8190 pobj mouse,in
R5570 T8193 T8194 compound XpdTTD , † XPCS
R5571 T8194 T8192 compound  † XPCS,mouse
R5572 T8195 T8194 punct /, † XPCS
R5573 T8196 T8184 punct .,Note
R5574 T8198 T8199 punct (,C
R5575 T8199 T8200 meta C,Quantification
R5576 T8201 T8199 punct ),C
R5577 T8202 T8200 prep of,Quantification
R5578 T8203 T8204 amod relative,density
R5579 T8204 T8202 pobj density,of
R5580 T8205 T8206 compound bone,mineral
R5581 T8206 T8204 compound mineral,density
R5582 T8207 T8204 prep of,density
R5583 T8208 T8209 compound tail,vertebrae
R5584 T8209 T8207 pobj vertebrae,of
R5585 T8210 T8209 prep from,vertebrae
R5586 T8211 T8212 nummod 20,mo
R5587 T8212 T8214 npadvmod mo,old
R5588 T8213 T8212 punct -,mo
R5589 T8214 T8216 amod old,mice
R5590 T8215 T8214 punct -,old
R5591 T8216 T8210 pobj mice,from
R5592 T8217 T8216 amod male,mice
R5593 T8218 T8216 nmod wt,mice
R5594 T8219 T8220 punct (,3
R5595 T8220 T8218 parataxis 3,wt
R5596 T8221 T8220 nsubj n,3
R5597 T8222 T8220 punct =,3
R5598 T8223 T8220 punct ),3
R5599 T8224 T8218 punct ", ",wt
R5600 T8225 T8226 compound XpdTTD,†XPCS
R5601 T8226 T8218 conj †XPCS,wt
R5602 T8227 T8226 punct /,†XPCS
R5603 T8228 T8229 punct (,4
R5604 T8229 T8226 parataxis 4,†XPCS
R5605 T8230 T8229 nsubj n,4
R5606 T8231 T8229 punct =,4
R5607 T8232 T8229 punct ),4
R5608 T8233 T8226 punct ", ",†XPCS
R5609 T8234 T8226 cc and,†XPCS
R5610 T8235 T8236 compound XpdTTD,TTD
R5611 T8236 T8226 conj TTD,†XPCS
R5612 T8237 T8236 punct /,TTD
R5613 T8238 T8239 punct (,3
R5614 T8239 T8236 parataxis 3,TTD
R5615 T8240 T8239 nsubj n,3
R5616 T8241 T8239 punct =,3
R5617 T8242 T8239 punct ),3
R5618 T8243 T8200 punct .,Quantification
R5619 T8245 T8246 det The,values
R5620 T8246 T8249 nsubj values,indicate
R5621 T8247 T8246 compound p,values
R5622 T8248 T8246 punct -,values
R5623 T8250 T8251 det the,significance
R5624 T8251 T8249 dobj significance,indicate
R5625 T8252 T8251 prep of,significance
R5626 T8253 T8254 det the,difference
R5627 T8254 T8252 pobj difference,of
R5628 T8255 T8249 advcl relative,indicate
R5629 T8256 T8255 prep to,relative
R5630 T8257 T8258 compound XpdTTD,TTD
R5631 T8258 T8256 pobj TTD,to
R5632 T8259 T8258 punct /,TTD
R5633 T8260 T8249 punct .,indicate
R5634 T8262 T8263 compound Error,bars
R5635 T8263 T8264 nsubj bars,indicate
R5636 T8265 T8264 dobj SEM,indicate
R5637 T8266 T8264 punct .,indicate
R5638 T8268 T8269 punct (,D
R5639 T8269 T8270 meta D,curves
R5640 T8271 T8269 punct ),D
R5641 T8272 T8273 compound Body,weight
R5642 T8273 T8270 compound weight,curves
R5643 T8274 T8270 prep as,curves
R5644 T8275 T8276 det a,function
R5645 T8276 T8274 pobj function,as
R5646 T8277 T8276 prep of,function
R5647 T8278 T8277 pobj time,of
R5648 T8279 T8270 punct .,curves
R5649 T8282 T8283 mark that,rescued
R5650 T8283 T8281 ccomp rescued,Note
R5651 T8284 T8285 det the,cachexia
R5652 T8285 T8283 nsubjpass cachexia,rescued
R5653 T8286 T8287 npadvmod age,dependent
R5654 T8287 T8285 amod dependent,cachexia
R5655 T8288 T8287 punct -,dependent
R5656 T8289 T8285 acl observed,cachexia
R5657 T8290 T8289 prep in,observed
R5658 T8291 T8292 compound XpdTTD,TTD
R5659 T8292 T8294 compound TTD,mice
R5660 T8293 T8292 punct /,TTD
R5661 T8294 T8290 pobj mice,in
R5662 T8295 T8283 auxpass was,rescued
R5663 T8296 T8283 prep in,rescued
R5664 T8297 T8298 preconj both,male
R5665 T8298 T8299 nmod male,mice
R5666 T8299 T8296 pobj mice,in
R5667 T8300 T8298 cc and,male
R5668 T8301 T8298 conj female,male
R5669 T8302 T8303 compound XpdTTD , †XPCS
R5670 T8303 T8299 compound  †XPCS,mice
R5671 T8304 T8303 punct /, †XPCS
R5672 T8305 T8281 punct .,Note
R5673 T8307 T8308 amod Significant,differences
R5674 T8308 T8309 nsubjpass differences,observed
R5675 T8310 T8308 prep between,differences
R5676 T8311 T8310 pobj wt,between
R5677 T8312 T8311 cc and,wt
R5678 T8313 T8314 compound XpdTTD,TTD
R5679 T8314 T8311 conj TTD,wt
R5680 T8315 T8314 punct /,TTD
R5681 T8316 T8310 cc but,between
R5682 T8317 T8316 neg not,but
R5683 T8318 T8310 conj between,between
R5684 T8319 T8320 nmod wt,mice
R5685 T8320 T8318 pobj mice,between
R5686 T8321 T8319 cc and,wt
R5687 T8322 T8323 compound XpdTTD,†XPCS
R5688 T8323 T8319 conj †XPCS,wt
R5689 T8324 T8323 punct /,†XPCS
R5690 T8325 T8309 auxpass were,observed
R5691 T8326 T8309 prep at,observed
R5692 T8327 T8328 nummod 9,mo
R5693 T8328 T8326 pobj mo,at
R5694 T8329 T8327 cc and,9
R5695 T8330 T8327 conj 18,9
R5696 T8331 T8328 prep of,mo
R5697 T8332 T8331 pobj age,of
R5698 T8333 T8334 mark as,indicated
R5699 T8334 T8309 advcl indicated,observed
R5700 T8335 T8334 agent by,indicated
R5701 T8336 T8335 pobj asterisks,by
R5702 T8337 T8309 punct .,observed
R5703 T8339 T8340 compound Error,bars
R5704 T8340 T8341 nsubj bars,indicate
R5705 T8342 T8341 dobj SEM,indicate
R5706 T8343 T8341 punct .,indicate
R6322 T9241 T9242 amod Pleiotropic,Effects
R6323 T9243 T9242 nmod Xpd,Effects
R6324 T9244 T9242 amod Biallelic,Effects
R6325 T9245 T9242 prep in,Effects
R6326 T9246 T9245 pobj Mice,in
R6327 T9247 T9246 cc and,Mice
R6328 T9248 T9246 conj Cells,Mice