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PMC:1584416 / 125-1662 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T96 0-8 IN denotes Although
T98 9-17 NN denotes compound
T99 18-32 NN denotes heterozygosity
T100 32-34 , denotes ,
T101 34-36 CC denotes or
T102 37-40 DT denotes the
T103 41-49 NN denotes presence
T104 50-52 IN denotes of
T105 53-56 CD denotes two
T107 57-66 JJ denotes different
T108 67-73 JJ denotes mutant
T106 74-81 NNS denotes alleles
T109 82-84 IN denotes of
T110 85-88 DT denotes the
T112 89-93 JJ denotes same
T111 94-98 NN denotes gene
T113 98-100 , denotes ,
T97 100-102 VBZ denotes is
T115 103-109 JJ denotes common
T116 110-112 IN denotes in
T117 113-118 JJ denotes human
T119 119-128 JJ denotes recessive
T118 129-136 NN denotes disease
T120 136-138 , denotes ,
T121 138-141 PRP$ denotes its
T122 142-151 NN denotes potential
T123 152-154 TO denotes to
T124 155-161 VB denotes impact
T125 162-169 NN denotes disease
T126 170-177 NN denotes outcome
T127 178-181 VBZ denotes has
T128 182-185 RB denotes not
T129 186-190 VBN denotes been
T130 191-195 RB denotes well
T114 196-206 VBN denotes documented
T131 206-207 . denotes .
T132 207-362 sentence denotes This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background.
T133 208-212 DT denotes This
T134 213-215 VBZ denotes is
T135 216-220 RBS denotes most
T136 221-227 RB denotes likely
T137 228-235 IN denotes because
T138 236-238 IN denotes of
T139 239-242 DT denotes the
T141 243-251 JJ denotes inherent
T140 252-262 NN denotes difficulty
T142 263-265 IN denotes in
T143 266-280 VBG denotes distinguishing
T144 281-289 JJ denotes specific
T146 290-299 JJ denotes biallelic
T145 300-307 NNS denotes effects
T147 308-312 IN denotes from
T148 313-324 NNS denotes differences
T149 325-327 IN denotes in
T150 328-339 NN denotes environment
T151 340-342 CC denotes or
T152 343-350 JJ denotes genetic
T153 351-361 NN denotes background
T154 361-362 . denotes .
T155 362-541 sentence denotes We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models.
T156 363-365 PRP denotes We
T157 366-375 VBD denotes addressed
T158 376-379 DT denotes the
T159 380-389 NN denotes potential
T160 390-392 IN denotes of
T161 393-402 JJ denotes different
T163 403-412 JJ denotes recessive
T162 413-420 NNS denotes alleles
T164 421-423 TO denotes to
T165 424-434 VB denotes contribute
T166 435-437 IN denotes to
T167 438-441 DT denotes the
T169 442-451 JJ denotes enigmatic
T168 452-462 NN denotes pleiotropy
T170 463-473 VBN denotes associated
T171 474-478 IN denotes with
T172 479-482 NN denotes XPD
T174 483-492 JJ denotes recessive
T173 493-502 NNS denotes disorders
T175 503-505 IN denotes in
T176 506-514 NN denotes compound
T178 515-527 JJ denotes heterozygous
T179 528-533 NN denotes mouse
T177 534-540 NNS denotes models
T180 540-541 . denotes .
T181 541-768 sentence denotes Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria.
T182 542-553 NNS denotes Alterations
T184 554-556 IN denotes in
T185 557-561 DT denotes this
T187 562-571 JJ denotes essential
T186 572-580 NN denotes helicase
T188 580-582 , denotes ,
T189 582-586 IN denotes with
T190 587-596 NNS denotes functions
T191 597-599 IN denotes in
T192 600-604 CC denotes both
T194 605-608 NN denotes DNA
T193 609-615 NN denotes repair
T195 616-619 CC denotes and
T196 620-625 JJ denotes basal
T197 626-639 NN denotes transcription
T198 639-641 , denotes ,
T183 641-647 VBP denotes result
T199 648-650 IN denotes in
T200 651-658 JJ denotes diverse
T201 659-670 NNS denotes pathologies
T202 671-678 VBG denotes ranging
T203 679-683 IN denotes from
T204 684-692 VBN denotes elevated
T206 693-695 NN denotes UV
T205 696-707 NN denotes sensitivity
T207 708-711 CC denotes and
T208 712-718 NN denotes cancer
T209 719-733 NN denotes predisposition
T210 734-736 IN denotes to
T211 737-748 VBN denotes accelerated
T213 749-758 JJ denotes segmental
T212 759-767 NN denotes progeria
T214 767-768 . denotes .
T215 768-1311 sentence denotes We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i) the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease-causing allele, (ii) differential developmental and tissue-specific functions of distinct Xpd allele products, and (iii) interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals.
T216 769-771 PRP denotes We
T217 772-778 VBP denotes report
T218 779-780 DT denotes a
T219 781-788 NN denotes variety
T220 789-791 IN denotes of
T221 792-801 JJ denotes biallelic
T222 802-809 NNS denotes effects
T223 810-812 IN denotes on
T224 813-823 JJ denotes organismal
T225 824-833 NN denotes phenotype
T226 834-846 JJ denotes attributable
T227 847-849 IN denotes to
T228 850-862 NNS denotes combinations
T229 863-865 IN denotes of
T230 866-875 JJ denotes recessive
T232 876-879 NN denotes Xpd
T231 880-887 NNS denotes alleles
T233 887-889 , denotes ,
T234 889-898 VBG denotes including
T235 899-902 DT denotes the
T236 903-912 NN denotes following
T237 912-914 : denotes :
T238 914-915 -LRB- denotes (
T239 915-916 LS denotes i
T241 916-917 -RRB- denotes )
T242 918-921 DT denotes the
T240 922-929 NN denotes ability
T243 930-932 IN denotes of
T244 933-943 JJ denotes homozygous
T246 944-950 JJ denotes lethal
T247 951-954 NN denotes Xpd
T245 955-962 NNS denotes alleles
T248 963-965 TO denotes to
T249 966-976 VB denotes ameliorate
T250 977-978 DT denotes a
T251 979-986 NN denotes variety
T252 987-989 IN denotes of
T253 990-997 NN denotes disease
T254 998-1006 NNS denotes symptoms
T255 1007-1011 WRB denotes when
T257 1012-1017 PRP$ denotes their
T259 1018-1027 JJ denotes essential
T260 1028-1033 JJ denotes basal
T261 1034-1047 NN denotes transcription
T258 1048-1056 NN denotes function
T262 1057-1059 VBZ denotes is
T256 1060-1068 VBN denotes supplied
T263 1069-1071 IN denotes by
T264 1072-1073 DT denotes a
T266 1074-1083 JJ denotes different
T267 1084-1091 NN denotes disease
T269 1091-1092 HYPH denotes -
T268 1092-1099 VBG denotes causing
T265 1100-1106 NN denotes allele
T270 1106-1108 , denotes ,
T271 1108-1109 -LRB- denotes (
T272 1109-1111 LS denotes ii
T274 1111-1112 -RRB- denotes )
T275 1113-1125 JJ denotes differential
T276 1126-1139 JJ denotes developmental
T277 1140-1143 CC denotes and
T278 1144-1150 NN denotes tissue
T280 1150-1151 HYPH denotes -
T279 1151-1159 JJ denotes specific
T273 1160-1169 NNS denotes functions
T281 1170-1172 IN denotes of
T282 1173-1181 JJ denotes distinct
T284 1182-1185 NN denotes Xpd
T285 1186-1192 NN denotes allele
T283 1193-1201 NNS denotes products
T286 1201-1203 , denotes ,
T287 1203-1206 CC denotes and
T288 1207-1208 -LRB- denotes (
T289 1208-1211 LS denotes iii
T291 1211-1212 -RRB- denotes )
T292 1213-1225 JJ denotes interallelic
T290 1226-1241 NN denotes complementation
T293 1241-1243 , denotes ,
T294 1243-1244 DT denotes a
T295 1245-1255 NN denotes phenomenon
T296 1256-1262 RB denotes rarely
T297 1263-1271 VBN denotes reported
T298 1272-1274 IN denotes at
T299 1275-1285 RB denotes clinically
T300 1286-1294 JJ denotes relevant
T301 1295-1299 NNS denotes loci
T302 1300-1302 IN denotes in
T303 1303-1310 NNS denotes mammals
T304 1310-1311 . denotes .
T305 1311-1537 sentence denotes Our data suggest a re-evaluation of the contribution of “null” alleles to XPD disorders and highlight the potential of combinations of recessive alleles to affect both normal and pathological phenotypic plasticity in mammals.
T306 1312-1315 PRP$ denotes Our
T307 1316-1320 NNS denotes data
T308 1321-1328 VBP denotes suggest
T309 1329-1330 DT denotes a
T310 1331-1344 NN denotes re-evaluation
T311 1345-1347 IN denotes of
T312 1348-1351 DT denotes the
T313 1352-1364 NN denotes contribution
T314 1365-1367 IN denotes of
T315 1368-1369 `` denotes “
T316 1369-1373 JJ denotes null
T318 1373-1374 '' denotes ”
T317 1375-1382 NNS denotes alleles
T319 1383-1385 IN denotes to
T320 1386-1389 NN denotes XPD
T321 1390-1399 NNS denotes disorders
T322 1400-1403 CC denotes and
T323 1404-1413 VBP denotes highlight
T324 1414-1417 DT denotes the
T325 1418-1427 NN denotes potential
T326 1428-1430 IN denotes of
T327 1431-1443 NNS denotes combinations
T328 1444-1446 IN denotes of
T329 1447-1456 JJ denotes recessive
T330 1457-1464 NNS denotes alleles
T331 1465-1467 TO denotes to
T332 1468-1474 VB denotes affect
T333 1475-1479 CC denotes both
T335 1480-1486 JJ denotes normal
T336 1487-1490 CC denotes and
T337 1491-1503 JJ denotes pathological
T338 1504-1514 JJ denotes phenotypic
T334 1515-1525 NN denotes plasticity
T339 1526-1528 IN denotes in
T340 1529-1536 NNS denotes mammals
T341 1536-1537 . denotes .
R10 T96 T97 mark Although,is
R100 T193 T191 pobj repair,in
R101 T194 T193 compound DNA,repair
R102 T195 T193 cc and,repair
R103 T196 T197 amod basal,transcription
R104 T197 T193 conj transcription,repair
R105 T198 T183 punct ", ",result
R106 T199 T183 prep in,result
R107 T200 T201 amod diverse,pathologies
R108 T201 T199 pobj pathologies,in
R109 T202 T201 acl ranging,pathologies
R11 T97 T114 advcl is,documented
R110 T203 T202 prep from,ranging
R111 T204 T205 amod elevated,sensitivity
R112 T205 T203 pobj sensitivity,from
R113 T206 T205 compound UV,sensitivity
R114 T207 T205 cc and,sensitivity
R115 T208 T209 compound cancer,predisposition
R116 T209 T205 conj predisposition,sensitivity
R117 T210 T203 prep to,from
R118 T211 T212 amod accelerated,progeria
R119 T212 T210 pobj progeria,to
R12 T98 T99 compound compound,heterozygosity
R120 T213 T212 amod segmental,progeria
R121 T214 T183 punct .,result
R122 T216 T217 nsubj We,report
R123 T218 T219 det a,variety
R124 T219 T217 dobj variety,report
R125 T220 T219 prep of,variety
R126 T221 T222 amod biallelic,effects
R127 T222 T220 pobj effects,of
R128 T223 T222 prep on,effects
R129 T224 T225 amod organismal,phenotype
R13 T99 T97 nsubj heterozygosity,is
R130 T225 T223 pobj phenotype,on
R131 T226 T222 amod attributable,effects
R132 T227 T226 prep to,attributable
R133 T228 T227 pobj combinations,to
R134 T229 T228 prep of,combinations
R135 T230 T231 amod recessive,alleles
R136 T231 T229 pobj alleles,of
R137 T232 T231 compound Xpd,alleles
R138 T233 T219 punct ", ",variety
R139 T234 T219 prep including,variety
R14 T100 T99 punct ", ",heterozygosity
R140 T235 T236 det the,following
R141 T236 T234 pobj following,including
R142 T237 T236 punct : ,following
R143 T238 T239 punct (,i
R144 T239 T240 meta i,ability
R145 T240 T236 appos ability,following
R146 T241 T239 punct ),i
R147 T242 T240 det the,ability
R148 T243 T240 prep of,ability
R149 T244 T245 amod homozygous,alleles
R15 T101 T99 cc or,heterozygosity
R150 T245 T243 pobj alleles,of
R151 T246 T245 amod lethal,alleles
R152 T247 T245 compound Xpd,alleles
R153 T248 T249 aux to,ameliorate
R154 T249 T240 acl ameliorate,ability
R155 T250 T251 det a,variety
R156 T251 T249 dobj variety,ameliorate
R157 T252 T251 prep of,variety
R158 T253 T254 compound disease,symptoms
R159 T254 T252 pobj symptoms,of
R16 T102 T103 det the,presence
R160 T255 T256 advmod when,supplied
R161 T256 T249 advcl supplied,ameliorate
R162 T257 T258 poss their,function
R163 T258 T256 nsubjpass function,supplied
R164 T259 T258 amod essential,function
R165 T260 T258 amod basal,function
R166 T261 T258 compound transcription,function
R167 T262 T256 auxpass is,supplied
R168 T263 T256 agent by,supplied
R169 T264 T265 det a,allele
R17 T103 T99 conj presence,heterozygosity
R170 T265 T263 pobj allele,by
R171 T266 T265 amod different,allele
R172 T267 T268 npadvmod disease,causing
R173 T268 T265 amod causing,allele
R174 T269 T268 punct -,causing
R175 T270 T240 punct ", ",ability
R176 T271 T272 punct (,ii
R177 T272 T273 meta ii,functions
R178 T273 T240 conj functions,ability
R179 T274 T272 punct ),ii
R18 T104 T103 prep of,presence
R180 T275 T276 amod differential,developmental
R181 T276 T273 amod developmental,functions
R182 T277 T276 cc and,developmental
R183 T278 T279 npadvmod tissue,specific
R184 T279 T276 conj specific,developmental
R185 T280 T279 punct -,specific
R186 T281 T273 prep of,functions
R187 T282 T283 amod distinct,products
R188 T283 T281 pobj products,of
R189 T284 T285 compound Xpd,allele
R19 T105 T106 nummod two,alleles
R190 T285 T283 compound allele,products
R191 T286 T273 punct ", ",functions
R192 T287 T273 cc and,functions
R193 T288 T289 punct (,iii
R194 T289 T290 meta iii,complementation
R195 T290 T273 conj complementation,functions
R196 T291 T289 punct ),iii
R197 T292 T290 amod interallelic,complementation
R198 T293 T290 punct ", ",complementation
R199 T294 T295 det a,phenomenon
R20 T106 T104 pobj alleles,of
R200 T295 T290 appos phenomenon,complementation
R201 T296 T297 advmod rarely,reported
R202 T297 T295 acl reported,phenomenon
R203 T298 T297 prep at,reported
R204 T299 T300 advmod clinically,relevant
R205 T300 T301 amod relevant,loci
R206 T301 T298 pobj loci,at
R207 T302 T301 prep in,loci
R208 T303 T302 pobj mammals,in
R209 T304 T217 punct .,report
R21 T107 T106 amod different,alleles
R210 T306 T307 poss Our,data
R211 T307 T308 nsubj data,suggest
R212 T309 T310 det a,re-evaluation
R213 T310 T308 dobj re-evaluation,suggest
R214 T311 T310 prep of,re-evaluation
R215 T312 T313 det the,contribution
R216 T313 T311 pobj contribution,of
R217 T314 T313 prep of,contribution
R218 T315 T314 punct “,of
R219 T316 T317 amod null,alleles
R22 T108 T106 amod mutant,alleles
R220 T317 T314 pobj alleles,of
R221 T318 T317 punct ”,alleles
R222 T319 T313 prep to,contribution
R223 T320 T321 compound XPD,disorders
R224 T321 T319 pobj disorders,to
R225 T322 T308 cc and,suggest
R226 T323 T308 conj highlight,suggest
R227 T324 T325 det the,potential
R228 T325 T323 dobj potential,highlight
R229 T326 T325 prep of,potential
R23 T109 T106 prep of,alleles
R230 T327 T326 pobj combinations,of
R231 T328 T327 prep of,combinations
R232 T329 T330 amod recessive,alleles
R233 T330 T328 pobj alleles,of
R234 T331 T332 aux to,affect
R235 T332 T325 acl affect,potential
R236 T333 T334 preconj both,plasticity
R237 T334 T332 dobj plasticity,affect
R238 T335 T334 amod normal,plasticity
R239 T336 T335 cc and,normal
R24 T110 T111 det the,gene
R240 T337 T335 conj pathological,normal
R241 T338 T334 amod phenotypic,plasticity
R242 T339 T332 prep in,affect
R243 T340 T339 pobj mammals,in
R244 T341 T308 punct .,suggest
R25 T111 T109 pobj gene,of
R26 T112 T111 amod same,gene
R27 T113 T97 punct ", ",is
R28 T115 T97 acomp common,is
R29 T116 T97 prep in,is
R30 T117 T118 amod human,disease
R31 T118 T116 pobj disease,in
R32 T119 T118 amod recessive,disease
R33 T120 T114 punct ", ",documented
R34 T121 T122 poss its,potential
R35 T122 T114 nsubjpass potential,documented
R36 T123 T124 aux to,impact
R37 T124 T122 acl impact,potential
R38 T125 T126 compound disease,outcome
R39 T126 T124 dobj outcome,impact
R40 T127 T114 aux has,documented
R41 T128 T114 neg not,documented
R42 T129 T114 auxpass been,documented
R43 T130 T114 advmod well,documented
R44 T131 T114 punct .,documented
R45 T133 T134 nsubj This,is
R46 T135 T136 advmod most,likely
R47 T136 T137 advmod likely,because
R48 T137 T134 prep because,is
R49 T138 T137 pcomp of,because
R50 T139 T140 det the,difficulty
R51 T140 T137 pobj difficulty,because
R52 T141 T140 amod inherent,difficulty
R53 T142 T140 prep in,difficulty
R54 T143 T142 pcomp distinguishing,in
R55 T144 T145 amod specific,effects
R56 T145 T143 dobj effects,distinguishing
R57 T146 T145 amod biallelic,effects
R58 T147 T143 prep from,distinguishing
R59 T148 T147 pobj differences,from
R60 T149 T148 prep in,differences
R61 T150 T149 pobj environment,in
R62 T151 T150 cc or,environment
R63 T152 T153 amod genetic,background
R64 T153 T150 conj background,environment
R65 T154 T134 punct .,is
R66 T156 T157 nsubj We,addressed
R67 T158 T159 det the,potential
R68 T159 T157 dobj potential,addressed
R69 T160 T159 prep of,potential
R70 T161 T162 amod different,alleles
R71 T162 T160 pobj alleles,of
R72 T163 T162 amod recessive,alleles
R73 T164 T165 aux to,contribute
R74 T165 T159 acl contribute,potential
R75 T166 T165 prep to,contribute
R76 T167 T168 det the,pleiotropy
R77 T168 T166 pobj pleiotropy,to
R78 T169 T168 amod enigmatic,pleiotropy
R79 T170 T168 acl associated,pleiotropy
R80 T171 T170 prep with,associated
R81 T172 T173 nmod XPD,disorders
R82 T173 T171 pobj disorders,with
R83 T174 T173 amod recessive,disorders
R84 T175 T170 prep in,associated
R85 T176 T177 nmod compound,models
R86 T177 T175 pobj models,in
R87 T178 T177 amod heterozygous,models
R88 T179 T177 compound mouse,models
R89 T180 T157 punct .,addressed
R90 T182 T183 nsubj Alterations,result
R91 T184 T182 prep in,Alterations
R92 T185 T186 det this,helicase
R93 T186 T184 pobj helicase,in
R94 T187 T186 amod essential,helicase
R95 T188 T186 punct ", ",helicase
R96 T189 T186 prep with,helicase
R97 T190 T189 pobj functions,with
R98 T191 T190 prep in,functions
R99 T192 T193 preconj both,repair