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PMC:1564426 / 46105-49905 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T25422 0-2 IN denotes In
T25424 3-7 DT denotes this
T25425 8-13 NN denotes study
T25426 13-15 , denotes ,
T25427 15-17 PRP denotes we
T25423 18-26 VBD denotes observed
T25428 27-31 IN denotes that
T25430 32-35 NN denotes K14
T25432 35-36 HYPH denotes -
T25431 36-42 VBN denotes driven
T25433 43-47 NN denotes loss
T25434 48-50 IN denotes of
T25435 51-54 NN denotes Apc
T25429 55-63 VBD denotes resulted
T25436 64-66 IN denotes in
T25437 67-68 DT denotes a
T25439 69-74 JJ denotes small
T25438 75-81 NN denotes thymus
T25440 82-86 IN denotes with
T25441 87-93 JJ denotes severe
T25443 94-102 JJ denotes squamous
T25442 103-113 NN denotes metaplasia
T25444 114-121 VBG denotes leading
T25445 122-124 IN denotes to
T25446 125-128 DT denotes the
T25447 129-138 NN denotes formation
T25448 139-141 IN denotes of
T25449 142-150 JJ denotes numerous
T25450 151-163 NN denotes pyogranuloma
T25451 164-167 CC denotes and
T25452 168-172 NN denotes loss
T25453 173-175 IN denotes of
T25454 176-182 JJ denotes proper
T25456 183-191 NN denotes meshwork
T25455 192-201 NN denotes structure
T25457 202-205 IN denotes for
T25458 206-215 NN denotes thymocyte
T25459 216-226 NN denotes maturation
T25460 226-228 , denotes ,
T25461 228-237 VBG denotes rendering
T25462 238-241 DT denotes the
T25463 242-246 NNS denotes mice
T25464 247-254 JJ denotes athymic
T25465 254-255 . denotes .
T25466 255-473 sentence denotes Previous studies have shown that in normal adult thymus K14 expression is found together with K5 in the stellate medullary TECs, but not in association with K5+ TECs in the cortex or at the cortico-medullary junction.
T25467 256-264 JJ denotes Previous
T25468 265-272 NNS denotes studies
T25470 273-277 VBP denotes have
T25469 278-283 VBN denotes shown
T25471 284-288 IN denotes that
T25473 289-291 IN denotes in
T25474 292-298 JJ denotes normal
T25476 299-304 JJ denotes adult
T25475 305-311 NN denotes thymus
T25477 312-315 NN denotes K14
T25478 316-326 NN denotes expression
T25479 327-329 VBZ denotes is
T25472 330-335 VBN denotes found
T25480 336-344 RB denotes together
T25482 345-349 IN denotes with
T25483 350-352 NN denotes K5
T25484 353-355 IN denotes in
T25485 356-359 DT denotes the
T25487 360-368 JJ denotes stellate
T25488 369-378 JJ denotes medullary
T25486 379-383 NNS denotes TECs
T25489 383-385 , denotes ,
T25490 385-388 CC denotes but
T25491 389-392 RB denotes not
T25481 393-395 IN denotes in
T25492 396-407 NN denotes association
T25493 408-412 IN denotes with
T25494 413-415 NN denotes K5
T25496 415-416 SYM denotes +
T25495 417-421 NNS denotes TECs
T25497 422-424 IN denotes in
T25498 425-428 DT denotes the
T25499 429-435 NN denotes cortex
T25500 436-438 CC denotes or
T25501 439-441 IN denotes at
T25502 442-445 DT denotes the
T25504 446-453 JJ denotes cortico
T25506 453-454 HYPH denotes -
T25505 454-463 JJ denotes medullary
T25503 464-472 NN denotes junction
T25507 472-473 . denotes .
T25508 473-665 sentence denotes In addition, it has been demonstrated that K14+ TECs do not coexpress K8; hence, there are two distinct medullary subsets, namely a K8−K14+ stellate subset and a K8+K14− globular subset [32].
T25509 474-476 IN denotes In
T25511 477-485 NN denotes addition
T25512 485-487 , denotes ,
T25513 487-489 PRP denotes it
T25514 490-493 VBZ denotes has
T25515 494-498 VBN denotes been
T25510 499-511 VBN denotes demonstrated
T25517 512-516 IN denotes that
T25519 517-520 NN denotes K14
T25521 520-521 SYM denotes +
T25520 522-526 NNS denotes TECs
T25522 527-529 VBP denotes do
T25523 530-533 RB denotes not
T25518 534-543 VB denotes coexpress
T25524 544-546 NN denotes K8
T25525 546-547 : denotes ;
T25526 548-553 RB denotes hence
T25527 553-555 , denotes ,
T25528 555-560 EX denotes there
T25516 561-564 VBP denotes are
T25529 565-568 CD denotes two
T25531 569-577 JJ denotes distinct
T25532 578-587 JJ denotes medullary
T25530 588-595 NNS denotes subsets
T25533 595-597 , denotes ,
T25534 597-603 RB denotes namely
T25536 604-605 DT denotes a
T25537 606-608 NN denotes K8
T25538 608-609 HYPH denotes −
T25539 609-612 NN denotes K14
T25540 612-613 SYM denotes +
T25541 614-622 JJ denotes stellate
T25535 623-629 NN denotes subset
T25542 630-633 CC denotes and
T25543 634-635 DT denotes a
T25545 636-638 NN denotes K8
T25546 638-639 SYM denotes +
T25547 639-642 NN denotes K14
T25548 642-643 SYM denotes −
T25549 644-652 JJ denotes globular
T25544 653-659 NN denotes subset
T25550 660-661 -LRB- denotes [
T25551 661-663 CD denotes 32
T25552 663-664 -RRB- denotes ]
T25553 664-665 . denotes .
T25554 665-867 sentence denotes In agreement with the previous results, in P3 normal thymus K14 expression was restricted to stellate medullary TECs (Figure 6D), whereas K8 expression was found throughout the TECs (unpublished data).
T25555 666-668 IN denotes In
T25557 669-678 NN denotes agreement
T25558 679-683 IN denotes with
T25559 684-687 DT denotes the
T25561 688-696 JJ denotes previous
T25560 697-704 NNS denotes results
T25562 704-706 , denotes ,
T25563 706-708 IN denotes in
T25564 709-711 NN denotes P3
T25566 712-718 JJ denotes normal
T25565 719-725 NN denotes thymus
T25567 726-729 NN denotes K14
T25568 730-740 NN denotes expression
T25569 741-744 VBD denotes was
T25556 745-755 VBN denotes restricted
T25570 756-758 IN denotes to
T25571 759-767 JJ denotes stellate
T25573 768-777 JJ denotes medullary
T25572 778-782 NNS denotes TECs
T25574 783-784 -LRB- denotes (
T25576 784-790 NN denotes Figure
T25575 791-793 NN denotes 6D
T25577 793-794 -RRB- denotes )
T25578 794-796 , denotes ,
T25579 796-803 IN denotes whereas
T25581 804-806 NN denotes K8
T25582 807-817 NN denotes expression
T25583 818-821 VBD denotes was
T25580 822-827 VBN denotes found
T25584 828-838 IN denotes throughout
T25585 839-842 DT denotes the
T25586 843-847 NNS denotes TECs
T25587 848-849 -LRB- denotes (
T25589 849-860 JJ denotes unpublished
T25588 861-865 NNS denotes data
T25590 865-866 -RRB- denotes )
T25591 866-867 . denotes .
T25592 867-974 sentence denotes We could not clarify whether these two keratins were coexpressed in the same TECs without double-staining.
T25593 868-870 PRP denotes We
T25595 871-876 MD denotes could
T25596 877-880 RB denotes not
T25594 881-888 VB denotes clarify
T25597 889-896 IN denotes whether
T25599 897-902 DT denotes these
T25601 903-906 CD denotes two
T25600 907-915 NNS denotes keratins
T25602 916-920 VBD denotes were
T25598 921-932 VBN denotes coexpressed
T25603 933-935 IN denotes in
T25604 936-939 DT denotes the
T25606 940-944 JJ denotes same
T25605 945-949 NNS denotes TECs
T25607 950-957 IN denotes without
T25608 958-964 NN denotes double
T25610 964-965 HYPH denotes -
T25609 965-973 NN denotes staining
T25611 973-974 . denotes .
T25612 974-1262 sentence denotes There were individual differences among mutants and these were prominently reflected in the histological abnormalities of the thymus at P3, but as the older surviving mutants all showed the same histopathologies of the thymus, the mutant thymi eventually seem to result in the same fate.
T25613 975-980 EX denotes There
T25614 981-985 VBD denotes were
T25615 986-996 JJ denotes individual
T25616 997-1008 NNS denotes differences
T25617 1009-1014 IN denotes among
T25618 1015-1022 NNS denotes mutants
T25619 1023-1026 CC denotes and
T25620 1027-1032 DT denotes these
T25622 1033-1037 VBD denotes were
T25623 1038-1049 RB denotes prominently
T25621 1050-1059 VBN denotes reflected
T25624 1060-1062 IN denotes in
T25625 1063-1066 DT denotes the
T25627 1067-1079 JJ denotes histological
T25626 1080-1093 NNS denotes abnormalities
T25628 1094-1096 IN denotes of
T25629 1097-1100 DT denotes the
T25630 1101-1107 NN denotes thymus
T25631 1108-1110 IN denotes at
T25632 1111-1113 NN denotes P3
T25633 1113-1115 , denotes ,
T25634 1115-1118 CC denotes but
T25635 1119-1121 IN denotes as
T25637 1122-1125 DT denotes the
T25639 1126-1131 JJR denotes older
T25640 1132-1141 VBG denotes surviving
T25638 1142-1149 NNS denotes mutants
T25641 1150-1153 DT denotes all
T25636 1154-1160 VBD denotes showed
T25643 1161-1164 DT denotes the
T25645 1165-1169 JJ denotes same
T25644 1170-1186 NNS denotes histopathologies
T25646 1187-1189 IN denotes of
T25647 1190-1193 DT denotes the
T25648 1194-1200 NN denotes thymus
T25649 1200-1202 , denotes ,
T25650 1202-1205 DT denotes the
T25652 1206-1212 JJ denotes mutant
T25651 1213-1218 NNS denotes thymi
T25653 1219-1229 RB denotes eventually
T25642 1230-1234 VBP denotes seem
T25654 1235-1237 TO denotes to
T25655 1238-1244 VB denotes result
T25656 1245-1247 IN denotes in
T25657 1248-1251 DT denotes the
T25659 1252-1256 JJ denotes same
T25658 1257-1261 NN denotes fate
T25660 1261-1262 . denotes .
T25661 1262-1732 sentence denotes It is unclear when K14-cre induction actually takes place in the mutant thymus, but as the population of cells showing a strong nuclear β-catenin staining as well as the cells expressing K14 were small and thymic epithelial compartments still existed in a mild P3 mutant thymus (Figure 6E and 6F), it seems that initial differentiation to medullary and cortical TECs and thymocyte colonization have already taken place prior to the major effects of K14-driven Apc loss.
T25662 1263-1265 PRP denotes It
T25663 1266-1268 VBZ denotes is
T25664 1269-1276 JJ denotes unclear
T25665 1277-1281 WRB denotes when
T25667 1282-1285 NN denotes K14
T25669 1285-1286 HYPH denotes -
T25668 1286-1289 NN denotes cre
T25670 1290-1299 NN denotes induction
T25671 1300-1308 RB denotes actually
T25666 1309-1314 VBZ denotes takes
T25672 1315-1320 NN denotes place
T25673 1321-1323 IN denotes in
T25674 1324-1327 DT denotes the
T25676 1328-1334 JJ denotes mutant
T25675 1335-1341 NN denotes thymus
T25677 1341-1343 , denotes ,
T25678 1343-1346 CC denotes but
T25679 1347-1349 IN denotes as
T25681 1350-1353 DT denotes the
T25682 1354-1364 NN denotes population
T25683 1365-1367 IN denotes of
T25684 1368-1373 NNS denotes cells
T25685 1374-1381 VBG denotes showing
T25686 1382-1383 DT denotes a
T25688 1384-1390 JJ denotes strong
T25689 1391-1398 JJ denotes nuclear
T25690 1399-1400 NN denotes β
T25692 1400-1401 HYPH denotes -
T25691 1401-1408 NN denotes catenin
T25687 1409-1417 NN denotes staining
T25693 1418-1420 RB denotes as
T25695 1421-1425 RB denotes well
T25694 1426-1428 IN denotes as
T25696 1429-1432 DT denotes the
T25697 1433-1438 NNS denotes cells
T25698 1439-1449 VBG denotes expressing
T25699 1450-1453 NN denotes K14
T25680 1454-1458 VBD denotes were
T25701 1459-1464 JJ denotes small
T25702 1465-1468 CC denotes and
T25703 1469-1475 JJ denotes thymic
T25705 1476-1486 JJ denotes epithelial
T25704 1487-1499 NNS denotes compartments
T25707 1500-1505 RB denotes still
T25706 1506-1513 VBD denotes existed
T25708 1514-1516 IN denotes in
T25709 1517-1518 DT denotes a
T25711 1519-1523 JJ denotes mild
T25712 1524-1526 NN denotes P3
T25713 1527-1533 JJ denotes mutant
T25710 1534-1540 NN denotes thymus
T25714 1541-1542 -LRB- denotes (
T25716 1542-1548 NN denotes Figure
T25715 1549-1551 NN denotes 6E
T25717 1552-1555 CC denotes and
T25718 1556-1558 NN denotes 6F
T25719 1558-1559 -RRB- denotes )
T25720 1559-1561 , denotes ,
T25721 1561-1563 PRP denotes it
T25700 1564-1569 VBZ denotes seems
T25722 1570-1574 IN denotes that
T25724 1575-1582 JJ denotes initial
T25725 1583-1598 NN denotes differentiation
T25726 1599-1601 IN denotes to
T25727 1602-1611 JJ denotes medullary
T25729 1612-1615 CC denotes and
T25730 1616-1624 JJ denotes cortical
T25728 1625-1629 NNS denotes TECs
T25731 1630-1633 CC denotes and
T25732 1634-1643 NN denotes thymocyte
T25733 1644-1656 NN denotes colonization
T25734 1657-1661 VBP denotes have
T25735 1662-1669 RB denotes already
T25723 1670-1675 VBN denotes taken
T25736 1676-1681 NN denotes place
T25737 1682-1687 JJ denotes prior
T25738 1688-1690 IN denotes to
T25739 1691-1694 DT denotes the
T25741 1695-1700 JJ denotes major
T25740 1701-1708 NNS denotes effects
T25742 1709-1711 IN denotes of
T25743 1712-1715 NN denotes K14
T25745 1715-1716 HYPH denotes -
T25744 1716-1722 VBN denotes driven
T25747 1723-1726 NN denotes Apc
T25746 1727-1731 NN denotes loss
T25748 1731-1732 . denotes .
T25749 1732-1935 sentence denotes However, cells with nuclear β-catenin and K8+K14+ double-positive epithelial cells increased subsequently, associated with active proliferation in the latter group of cells and loss of TEC compartments.
T25750 1733-1740 RB denotes However
T25752 1740-1742 , denotes ,
T25753 1742-1747 NNS denotes cells
T25754 1748-1752 IN denotes with
T25755 1753-1760 JJ denotes nuclear
T25757 1761-1762 NN denotes β
T25758 1762-1763 HYPH denotes -
T25756 1763-1770 NN denotes catenin
T25760 1771-1774 CC denotes and
T25761 1775-1777 NN denotes K8
T25763 1777-1778 SYM denotes +
T25764 1778-1781 NN denotes K14
T25765 1781-1782 SYM denotes +
T25766 1783-1789 JJ denotes double
T25767 1789-1790 HYPH denotes -
T25762 1790-1798 JJ denotes positive
T25768 1799-1809 JJ denotes epithelial
T25759 1810-1815 NNS denotes cells
T25751 1816-1825 VBD denotes increased
T25769 1826-1838 RB denotes subsequently
T25770 1838-1840 , denotes ,
T25771 1840-1850 JJ denotes associated
T25772 1851-1855 IN denotes with
T25773 1856-1862 JJ denotes active
T25774 1863-1876 NN denotes proliferation
T25775 1877-1879 IN denotes in
T25776 1880-1883 DT denotes the
T25778 1884-1890 JJ denotes latter
T25777 1891-1896 NN denotes group
T25779 1897-1899 IN denotes of
T25780 1900-1905 NNS denotes cells
T25781 1906-1909 CC denotes and
T25782 1910-1914 NN denotes loss
T25783 1915-1917 IN denotes of
T25784 1918-1921 NN denotes TEC
T25785 1922-1934 NNS denotes compartments
T25786 1934-1935 . denotes .
T25787 1935-2226 sentence denotes With age, β-catenin expression pattern became more diffuse and fewer epithelial cells showed nuclear localization but K8+K14+ cells remained, forming concentric structures of epithelial cells filled with hard keratin deposits and infiltrated with vast number of neutrophils and macrophages.
T25788 1936-1940 IN denotes With
T25790 1941-1944 NN denotes age
T25791 1944-1946 , denotes ,
T25792 1946-1947 NN denotes β
T25794 1947-1948 HYPH denotes -
T25793 1948-1955 NN denotes catenin
T25796 1956-1966 NN denotes expression
T25795 1967-1974 NN denotes pattern
T25789 1975-1981 VBD denotes became
T25797 1982-1986 RBR denotes more
T25798 1987-1994 JJ denotes diffuse
T25799 1995-1998 CC denotes and
T25800 1999-2004 JJR denotes fewer
T25802 2005-2015 JJ denotes epithelial
T25801 2016-2021 NNS denotes cells
T25803 2022-2028 VBD denotes showed
T25804 2029-2036 JJ denotes nuclear
T25805 2037-2049 NN denotes localization
T25806 2050-2053 CC denotes but
T25807 2054-2056 NN denotes K8
T25809 2056-2057 SYM denotes +
T25810 2057-2060 NN denotes K14
T25811 2060-2061 SYM denotes +
T25808 2062-2067 NNS denotes cells
T25812 2068-2076 VBD denotes remained
T25813 2076-2078 , denotes ,
T25814 2078-2085 VBG denotes forming
T25815 2086-2096 JJ denotes concentric
T25816 2097-2107 NNS denotes structures
T25817 2108-2110 IN denotes of
T25818 2111-2121 JJ denotes epithelial
T25819 2122-2127 NNS denotes cells
T25820 2128-2134 VBN denotes filled
T25821 2135-2139 IN denotes with
T25822 2140-2144 JJ denotes hard
T25824 2145-2152 NN denotes keratin
T25823 2153-2161 NNS denotes deposits
T25825 2162-2165 CC denotes and
T25826 2166-2177 VBN denotes infiltrated
T25827 2178-2182 IN denotes with
T25828 2183-2187 JJ denotes vast
T25829 2188-2194 NN denotes number
T25830 2195-2197 IN denotes of
T25831 2198-2209 NNS denotes neutrophils
T25832 2210-2213 CC denotes and
T25833 2214-2225 NNS denotes macrophages
T25834 2225-2226 . denotes .
T25835 2226-2321 sentence denotes Only a few epithelial cells were dividing and hardly any thymocytes were present by this time.
T25836 2227-2231 RB denotes Only
T25838 2232-2233 DT denotes a
T25839 2234-2237 JJ denotes few
T25840 2238-2248 JJ denotes epithelial
T25837 2249-2254 NNS denotes cells
T25842 2255-2259 VBD denotes were
T25841 2260-2268 VBG denotes dividing
T25843 2269-2272 CC denotes and
T25844 2273-2279 RB denotes hardly
T25846 2280-2283 DT denotes any
T25845 2284-2294 NNS denotes thymocytes
T25847 2295-2299 VBD denotes were
T25848 2300-2307 JJ denotes present
T25849 2308-2310 IN denotes by
T25850 2311-2315 DT denotes this
T25851 2316-2320 NN denotes time
T25852 2320-2321 . denotes .
T25853 2321-2606 sentence denotes These results suggest that with the deletion of Apc in TECs, stabililization and nuclear localization of β-catenin took place and subsequently these cells differentiated into keratinocytes that expressed both K14 and K8, similar to the basal cells of the skin, instead of TEC subsets.
T25854 2322-2327 DT denotes These
T25855 2328-2335 NNS denotes results
T25856 2336-2343 VBP denotes suggest
T25857 2344-2348 IN denotes that
T25859 2349-2353 IN denotes with
T25860 2354-2357 DT denotes the
T25861 2358-2366 NN denotes deletion
T25862 2367-2369 IN denotes of
T25863 2370-2373 NN denotes Apc
T25864 2374-2376 IN denotes in
T25865 2377-2381 NNS denotes TECs
T25866 2381-2383 , denotes ,
T25867 2383-2398 NN denotes stabililization
T25868 2399-2402 CC denotes and
T25869 2403-2410 JJ denotes nuclear
T25870 2411-2423 NN denotes localization
T25871 2424-2426 IN denotes of
T25872 2427-2428 NN denotes β
T25874 2428-2429 HYPH denotes -
T25873 2429-2436 NN denotes catenin
T25858 2437-2441 VBD denotes took
T25875 2442-2447 NN denotes place
T25876 2448-2451 CC denotes and
T25877 2452-2464 RB denotes subsequently
T25879 2465-2470 DT denotes these
T25880 2471-2476 NNS denotes cells
T25878 2477-2491 VBD denotes differentiated
T25881 2492-2496 IN denotes into
T25882 2497-2510 NNS denotes keratinocytes
T25883 2511-2515 WDT denotes that
T25884 2516-2525 VBD denotes expressed
T25885 2526-2530 CC denotes both
T25886 2531-2534 NN denotes K14
T25887 2535-2538 CC denotes and
T25888 2539-2541 NN denotes K8
T25889 2541-2543 , denotes ,
T25890 2543-2550 JJ denotes similar
T25891 2551-2553 IN denotes to
T25892 2554-2557 DT denotes the
T25894 2558-2563 JJ denotes basal
T25893 2564-2569 NNS denotes cells
T25895 2570-2572 IN denotes of
T25896 2573-2576 DT denotes the
T25897 2577-2581 NN denotes skin
T25898 2581-2583 , denotes ,
T25899 2583-2590 RB denotes instead
T25900 2591-2593 IN denotes of
T25901 2594-2597 NN denotes TEC
T25902 2598-2605 NNS denotes subsets
T25903 2605-2606 . denotes .
T25904 2606-2864 sentence denotes The expansion and differentiation of these keratinocytes lead to loss of proper thymic epithelial compartments and in turn produced and deposited the hard keratins that consequently caused vast amount of neutrophils and macrophages to infiltrate the thymus.
T25905 2607-2610 DT denotes The
T25906 2611-2620 NN denotes expansion
T25908 2621-2624 CC denotes and
T25909 2625-2640 NN denotes differentiation
T25910 2641-2643 IN denotes of
T25911 2644-2649 DT denotes these
T25912 2650-2663 NNS denotes keratinocytes
T25907 2664-2668 VBP denotes lead
T25913 2669-2671 IN denotes to
T25914 2672-2676 NN denotes loss
T25915 2677-2679 IN denotes of
T25916 2680-2686 JJ denotes proper
T25918 2687-2693 JJ denotes thymic
T25919 2694-2704 JJ denotes epithelial
T25917 2705-2717 NNS denotes compartments
T25920 2718-2721 CC denotes and
T25921 2722-2724 IN denotes in
T25923 2725-2729 NN denotes turn
T25922 2730-2738 VBD denotes produced
T25924 2739-2742 CC denotes and
T25925 2743-2752 VBD denotes deposited
T25926 2753-2756 DT denotes the
T25928 2757-2761 JJ denotes hard
T25927 2762-2770 NNS denotes keratins
T25929 2771-2775 WDT denotes that
T25931 2776-2788 RB denotes consequently
T25930 2789-2795 VBD denotes caused
T25932 2796-2800 JJ denotes vast
T25933 2801-2807 NN denotes amount
T25935 2808-2810 IN denotes of
T25936 2811-2822 NNS denotes neutrophils
T25937 2823-2826 CC denotes and
T25938 2827-2838 NNS denotes macrophages
T25939 2839-2841 TO denotes to
T25934 2842-2852 VB denotes infiltrate
T25940 2853-2856 DT denotes the
T25941 2857-2863 NN denotes thymus
T25942 2863-2864 . denotes .
T25943 2864-2992 sentence denotes These aberrant epithelial structures eventually have overtaken the whole of the thymus and driven out the colonized thymocytes.
T25944 2865-2870 DT denotes These
T25946 2871-2879 JJ denotes aberrant
T25947 2880-2890 JJ denotes epithelial
T25945 2891-2901 NNS denotes structures
T25949 2902-2912 RB denotes eventually
T25950 2913-2917 VBP denotes have
T25948 2918-2927 VBN denotes overtaken
T25951 2928-2931 DT denotes the
T25952 2932-2937 NN denotes whole
T25953 2938-2940 IN denotes of
T25954 2941-2944 DT denotes the
T25955 2945-2951 NN denotes thymus
T25956 2952-2955 CC denotes and
T25957 2956-2962 VBN denotes driven
T25958 2963-2966 RP denotes out
T25959 2967-2970 DT denotes the
T25961 2971-2980 VBN denotes colonized
T25960 2981-2991 NNS denotes thymocytes
T25962 2991-2992 . denotes .
T25963 2992-3265 sentence denotes K14-driven loss of Apc and subsequent constitutive expression of β-catenin in TECs have therefore misdirected them to wrong epithelial cell fate, not allowing proper differentiation to either cortical or medullary TECs, which is essential for normal thymocyte development.
T25964 2993-2996 NN denotes K14
T25966 2996-2997 HYPH denotes -
T25965 2997-3003 VBN denotes driven
T25967 3004-3008 NN denotes loss
T25969 3009-3011 IN denotes of
T25970 3012-3015 NN denotes Apc
T25971 3016-3019 CC denotes and
T25972 3020-3030 JJ denotes subsequent
T25974 3031-3043 JJ denotes constitutive
T25973 3044-3054 NN denotes expression
T25975 3055-3057 IN denotes of
T25976 3058-3059 NN denotes β
T25978 3059-3060 HYPH denotes -
T25977 3060-3067 NN denotes catenin
T25979 3068-3070 IN denotes in
T25980 3071-3075 NNS denotes TECs
T25981 3076-3080 VBP denotes have
T25982 3081-3090 RB denotes therefore
T25968 3091-3102 VBN denotes misdirected
T25983 3103-3107 PRP denotes them
T25984 3108-3110 IN denotes to
T25985 3111-3116 JJ denotes wrong
T25987 3117-3127 JJ denotes epithelial
T25988 3128-3132 NN denotes cell
T25986 3133-3137 NN denotes fate
T25989 3137-3139 , denotes ,
T25990 3139-3142 RB denotes not
T25991 3143-3151 VBG denotes allowing
T25992 3152-3158 JJ denotes proper
T25993 3159-3174 NN denotes differentiation
T25994 3175-3177 IN denotes to
T25995 3178-3184 CC denotes either
T25996 3185-3193 JJ denotes cortical
T25998 3194-3196 CC denotes or
T25999 3197-3206 JJ denotes medullary
T25997 3207-3211 NNS denotes TECs
T26000 3211-3213 , denotes ,
T26001 3213-3218 WDT denotes which
T26002 3219-3221 VBZ denotes is
T26003 3222-3231 JJ denotes essential
T26004 3232-3235 IN denotes for
T26005 3236-3242 JJ denotes normal
T26007 3243-3252 NN denotes thymocyte
T26006 3253-3264 NN denotes development
T26008 3264-3265 . denotes .
T26009 3265-3458 sentence denotes This is not only evident from the lack of dividing thymocytes in the mutant thymus by P13, but also by the differential expression pattern of keratins, which were more skin-like than TEC-like.
T26010 3266-3270 DT denotes This
T26011 3271-3273 VBZ denotes is
T26012 3274-3277 RB denotes not
T26013 3278-3282 RB denotes only
T26014 3283-3290 JJ denotes evident
T26015 3291-3295 IN denotes from
T26016 3296-3299 DT denotes the
T26017 3300-3304 NN denotes lack
T26018 3305-3307 IN denotes of
T26019 3308-3316 VBG denotes dividing
T26020 3317-3327 NNS denotes thymocytes
T26021 3328-3330 IN denotes in
T26022 3331-3334 DT denotes the
T26024 3335-3341 JJ denotes mutant
T26023 3342-3348 NN denotes thymus
T26025 3349-3351 IN denotes by
T26026 3352-3355 NN denotes P13
T26027 3355-3357 , denotes ,
T26028 3357-3360 CC denotes but
T26029 3361-3365 RB denotes also
T26030 3366-3368 IN denotes by
T26031 3369-3372 DT denotes the
T26033 3373-3385 JJ denotes differential
T26034 3386-3396 NN denotes expression
T26032 3397-3404 NN denotes pattern
T26035 3405-3407 IN denotes of
T26036 3408-3416 NNS denotes keratins
T26037 3416-3418 , denotes ,
T26038 3418-3423 WDT denotes which
T26039 3424-3428 VBD denotes were
T26040 3429-3433 RBR denotes more
T26042 3434-3438 NN denotes skin
T26043 3438-3439 HYPH denotes -
T26041 3439-3443 JJ denotes like
T26044 3444-3448 IN denotes than
T26045 3449-3452 NN denotes TEC
T26047 3452-3453 HYPH denotes -
T26046 3453-3457 JJ denotes like
T26048 3457-3458 . denotes .
T26049 3458-3655 sentence denotes The importance of Apc function in thymic development has been demonstrated by thymocyte-specific loss of Apc by crossing a different strain of Apc conditional mice and LckCre transgenic mice [33].
T26050 3459-3462 DT denotes The
T26051 3463-3473 NN denotes importance
T26053 3474-3476 IN denotes of
T26054 3477-3480 NN denotes Apc
T26055 3481-3489 NN denotes function
T26056 3490-3492 IN denotes in
T26057 3493-3499 JJ denotes thymic
T26058 3500-3511 NN denotes development
T26059 3512-3515 VBZ denotes has
T26060 3516-3520 VBN denotes been
T26052 3521-3533 VBN denotes demonstrated
T26061 3534-3536 IN denotes by
T26062 3537-3546 NN denotes thymocyte
T26064 3546-3547 HYPH denotes -
T26063 3547-3555 JJ denotes specific
T26065 3556-3560 NN denotes loss
T26066 3561-3563 IN denotes of
T26067 3564-3567 NN denotes Apc
T26068 3568-3570 IN denotes by
T26069 3571-3579 VBG denotes crossing
T26070 3580-3581 DT denotes a
T26072 3582-3591 JJ denotes different
T26071 3592-3598 NN denotes strain
T26073 3599-3601 IN denotes of
T26074 3602-3605 NN denotes Apc
T26076 3606-3617 JJ denotes conditional
T26075 3618-3622 NNS denotes mice
T26077 3623-3626 CC denotes and
T26078 3627-3633 NN denotes LckCre
T26080 3634-3644 JJ denotes transgenic
T26079 3645-3649 NNS denotes mice
T26081 3650-3651 -LRB- denotes [
T26082 3651-3653 CD denotes 33
T26083 3653-3654 -RRB- denotes ]
T26084 3654-3655 . denotes .
T26085 3655-3800 sentence denotes Here, by K14-driven TEC-specific loss of Apc, we have demonstrated its importance in thymus development not only in thymocytes but also in TECs.
T26086 3656-3660 RB denotes Here
T26088 3660-3662 , denotes ,
T26089 3662-3664 IN denotes by
T26090 3665-3668 NN denotes K14
T26092 3668-3669 HYPH denotes -
T26091 3669-3675 VBN denotes driven
T26094 3676-3679 NN denotes TEC
T26096 3679-3680 HYPH denotes -
T26095 3680-3688 JJ denotes specific
T26093 3689-3693 NN denotes loss
T26097 3694-3696 IN denotes of
T26098 3697-3700 NN denotes Apc
T26099 3700-3702 , denotes ,
T26100 3702-3704 PRP denotes we
T26101 3705-3709 VBP denotes have
T26087 3710-3722 VBN denotes demonstrated
T26102 3723-3726 PRP$ denotes its
T26103 3727-3737 NN denotes importance
T26104 3738-3740 IN denotes in
T26105 3741-3747 NN denotes thymus
T26106 3748-3759 NN denotes development
T26107 3760-3763 RB denotes not
T26109 3764-3768 RB denotes only
T26108 3769-3771 IN denotes in
T26110 3772-3782 NNS denotes thymocytes
T26111 3783-3786 CC denotes but
T26112 3787-3791 RB denotes also
T26113 3792-3794 IN denotes in
T26114 3795-3799 NNS denotes TECs
T26115 3799-3800 . denotes .
R7224 T25422 T25423 prep In,observed
R7225 T25424 T25425 det this,study
R7226 T25425 T25422 pobj study,In
R7227 T25426 T25423 punct ", ",observed
R7228 T25427 T25423 nsubj we,observed
R7229 T25428 T25429 mark that,resulted
R7230 T25429 T25423 ccomp resulted,observed
R7231 T25430 T25431 npadvmod K14,driven
R7232 T25431 T25433 amod driven,loss
R7233 T25432 T25431 punct -,driven
R7234 T25433 T25429 nsubj loss,resulted
R7235 T25434 T25433 prep of,loss
R7236 T25435 T25434 pobj Apc,of
R7237 T25436 T25429 prep in,resulted
R7238 T25437 T25438 det a,thymus
R7239 T25438 T25436 pobj thymus,in
R7240 T25439 T25438 amod small,thymus
R7241 T25440 T25438 prep with,thymus
R7242 T25441 T25442 amod severe,metaplasia
R7243 T25442 T25440 pobj metaplasia,with
R7244 T25443 T25442 amod squamous,metaplasia
R7245 T25444 T25442 acl leading,metaplasia
R7246 T25445 T25444 prep to,leading
R7247 T25446 T25447 det the,formation
R7248 T25447 T25445 pobj formation,to
R7249 T25448 T25447 prep of,formation
R7250 T25449 T25450 amod numerous,pyogranuloma
R7251 T25450 T25448 pobj pyogranuloma,of
R7252 T25451 T25447 cc and,formation
R7253 T25452 T25447 conj loss,formation
R7254 T25453 T25452 prep of,loss
R7255 T25454 T25455 amod proper,structure
R7256 T25455 T25453 pobj structure,of
R7257 T25456 T25455 compound meshwork,structure
R7258 T25457 T25455 prep for,structure
R7259 T25458 T25459 compound thymocyte,maturation
R7260 T25459 T25457 pobj maturation,for
R7261 T25460 T25429 punct ", ",resulted
R7262 T25461 T25429 advcl rendering,resulted
R7263 T25462 T25463 det the,mice
R7264 T25463 T25461 dobj mice,rendering
R7265 T25464 T25461 oprd athymic,rendering
R7266 T25465 T25423 punct .,observed
R7267 T25467 T25468 amod Previous,studies
R7268 T25468 T25469 nsubj studies,shown
R7269 T25470 T25469 aux have,shown
R7270 T25471 T25472 mark that,found
R7271 T25472 T25469 ccomp found,shown
R7272 T25473 T25472 prep in,found
R7273 T25474 T25475 amod normal,thymus
R7274 T25475 T25473 pobj thymus,in
R7275 T25476 T25475 amod adult,thymus
R7276 T25477 T25478 compound K14,expression
R7277 T25478 T25472 nsubjpass expression,found
R7278 T25479 T25472 auxpass is,found
R7279 T25480 T25481 advmod together,in
R7280 T25481 T25472 prep in,found
R7281 T25482 T25480 prep with,together
R7282 T25483 T25482 pobj K5,with
R7283 T25484 T25483 prep in,K5
R7284 T25485 T25486 det the,TECs
R7285 T25486 T25484 pobj TECs,in
R7286 T25487 T25486 amod stellate,TECs
R7287 T25488 T25486 amod medullary,TECs
R7288 T25489 T25481 punct ", ",in
R7289 T25490 T25481 cc but,in
R7290 T25491 T25490 neg not,but
R7291 T25492 T25481 pobj association,in
R7292 T25493 T25492 prep with,association
R7293 T25494 T25495 nmod K5,TECs
R7294 T25495 T25493 pobj TECs,with
R7295 T25496 T25494 punct +,K5
R7296 T25497 T25492 prep in,association
R7297 T25498 T25499 det the,cortex
R7298 T25499 T25497 pobj cortex,in
R7299 T25500 T25497 cc or,in
R7300 T25501 T25497 conj at,in
R7301 T25502 T25503 det the,junction
R7302 T25503 T25501 pobj junction,at
R7303 T25504 T25505 amod cortico,medullary
R7304 T25505 T25503 amod medullary,junction
R7305 T25506 T25505 punct -,medullary
R7306 T25507 T25469 punct .,shown
R7307 T25509 T25510 prep In,demonstrated
R7308 T25510 T25516 ccomp demonstrated,are
R7309 T25511 T25509 pobj addition,In
R7310 T25512 T25510 punct ", ",demonstrated
R7311 T25513 T25510 nsubjpass it,demonstrated
R7312 T25514 T25510 aux has,demonstrated
R7313 T25515 T25510 auxpass been,demonstrated
R7314 T25517 T25518 mark that,coexpress
R7315 T25518 T25510 ccomp coexpress,demonstrated
R7316 T25519 T25520 nmod K14,TECs
R7317 T25520 T25518 nsubj TECs,coexpress
R7318 T25521 T25519 punct +,K14
R7319 T25522 T25518 aux do,coexpress
R7320 T25523 T25518 neg not,coexpress
R7321 T25524 T25518 dobj K8,coexpress
R7322 T25525 T25516 punct ;,are
R7323 T25526 T25516 advmod hence,are
R7324 T25527 T25516 punct ", ",are
R7325 T25528 T25516 expl there,are
R7326 T25529 T25530 nummod two,subsets
R7327 T25530 T25516 attr subsets,are
R7328 T25531 T25530 amod distinct,subsets
R7329 T25532 T25530 amod medullary,subsets
R7330 T25533 T25530 punct ", ",subsets
R7331 T25534 T25535 advmod namely,subset
R7332 T25535 T25530 appos subset,subsets
R7333 T25536 T25535 det a,subset
R7334 T25537 T25535 nmod K8,subset
R7335 T25538 T25537 punct −,K8
R7336 T25539 T25535 nmod K14,subset
R7337 T25540 T25539 punct +,K14
R7338 T25541 T25535 amod stellate,subset
R7339 T25542 T25535 cc and,subset
R7340 T25543 T25544 det a,subset
R7341 T25544 T25535 conj subset,subset
R7342 T25545 T25544 nmod K8,subset
R7343 T25546 T25545 punct +,K8
R7344 T25547 T25544 nmod K14,subset
R7345 T25548 T25547 punct −,K14
R7346 T25549 T25544 amod globular,subset
R7347 T25550 T25551 punct [,32
R7348 T25551 T25516 parataxis 32,are
R7349 T25552 T25551 punct ],32
R7350 T25553 T25516 punct .,are
R7351 T25555 T25556 prep In,restricted
R7352 T25557 T25555 pobj agreement,In
R7353 T25558 T25557 prep with,agreement
R7354 T25559 T25560 det the,results
R7355 T25560 T25558 pobj results,with
R7356 T25561 T25560 amod previous,results
R7357 T25562 T25556 punct ", ",restricted
R7358 T25563 T25556 prep in,restricted
R7359 T25564 T25565 nmod P3,thymus
R7360 T25565 T25563 pobj thymus,in
R7361 T25566 T25565 amod normal,thymus
R7362 T25567 T25568 compound K14,expression
R7363 T25568 T25556 nsubjpass expression,restricted
R7364 T25569 T25556 auxpass was,restricted
R7365 T25570 T25556 prep to,restricted
R7366 T25571 T25572 amod stellate,TECs
R7367 T25572 T25570 pobj TECs,to
R7368 T25573 T25572 amod medullary,TECs
R7369 T25574 T25575 punct (,6D
R7370 T25575 T25556 parataxis 6D,restricted
R7371 T25576 T25575 compound Figure,6D
R7372 T25577 T25575 punct ),6D
R7373 T25578 T25556 punct ", ",restricted
R7374 T25579 T25580 mark whereas,found
R7375 T25580 T25556 advcl found,restricted
R7376 T25581 T25582 compound K8,expression
R7377 T25582 T25580 nsubjpass expression,found
R7378 T25583 T25580 auxpass was,found
R7379 T25584 T25580 prep throughout,found
R7380 T25585 T25586 det the,TECs
R7381 T25586 T25584 pobj TECs,throughout
R7382 T25587 T25588 punct (,data
R7383 T25588 T25556 meta data,restricted
R7384 T25589 T25588 amod unpublished,data
R7385 T25590 T25588 punct ),data
R7386 T25591 T25556 punct .,restricted
R7387 T25593 T25594 nsubj We,clarify
R7388 T25595 T25594 aux could,clarify
R7389 T25596 T25594 neg not,clarify
R7390 T25597 T25598 mark whether,coexpressed
R7391 T25598 T25594 ccomp coexpressed,clarify
R7392 T25599 T25600 det these,keratins
R7393 T25600 T25598 nsubjpass keratins,coexpressed
R7394 T25601 T25600 nummod two,keratins
R7395 T25602 T25598 auxpass were,coexpressed
R7396 T25603 T25598 prep in,coexpressed
R7397 T25604 T25605 det the,TECs
R7398 T25605 T25603 pobj TECs,in
R7399 T25606 T25605 amod same,TECs
R7400 T25607 T25598 prep without,coexpressed
R7401 T25608 T25609 compound double,staining
R7402 T25609 T25607 pobj staining,without
R7403 T25610 T25609 punct -,staining
R7404 T25611 T25594 punct .,clarify
R7405 T25613 T25614 expl There,were
R7406 T25615 T25616 amod individual,differences
R7407 T25616 T25614 attr differences,were
R7408 T25617 T25614 prep among,were
R7409 T25618 T25617 pobj mutants,among
R7410 T25619 T25614 cc and,were
R7411 T25620 T25621 nsubjpass these,reflected
R7412 T25621 T25614 conj reflected,were
R7413 T25622 T25621 auxpass were,reflected
R7414 T25623 T25621 advmod prominently,reflected
R7415 T25624 T25621 prep in,reflected
R7416 T25625 T25626 det the,abnormalities
R7417 T25626 T25624 pobj abnormalities,in
R7418 T25627 T25626 amod histological,abnormalities
R7419 T25628 T25626 prep of,abnormalities
R7420 T25629 T25630 det the,thymus
R7421 T25630 T25628 pobj thymus,of
R7422 T25631 T25621 prep at,reflected
R7423 T25632 T25631 pobj P3,at
R7424 T25633 T25614 punct ", ",were
R7425 T25634 T25614 cc but,were
R7426 T25635 T25636 mark as,showed
R7427 T25636 T25642 advcl showed,seem
R7428 T25637 T25638 det the,mutants
R7429 T25638 T25636 nsubj mutants,showed
R7430 T25639 T25638 amod older,mutants
R7431 T25640 T25638 amod surviving,mutants
R7432 T25641 T25638 appos all,mutants
R7433 T25642 T25614 conj seem,were
R7434 T25643 T25644 det the,histopathologies
R7435 T25644 T25636 dobj histopathologies,showed
R7436 T25645 T25644 amod same,histopathologies
R7437 T25646 T25644 prep of,histopathologies
R7438 T25647 T25648 det the,thymus
R7439 T25648 T25646 pobj thymus,of
R7440 T25649 T25642 punct ", ",seem
R7441 T25650 T25651 det the,thymi
R7442 T25651 T25642 nsubj thymi,seem
R7443 T25652 T25651 amod mutant,thymi
R7444 T25653 T25642 advmod eventually,seem
R7445 T25654 T25655 aux to,result
R7446 T25655 T25642 xcomp result,seem
R7447 T25656 T25655 prep in,result
R7448 T25657 T25658 det the,fate
R7449 T25658 T25656 pobj fate,in
R7450 T25659 T25658 amod same,fate
R7451 T25660 T25642 punct .,seem
R7452 T25662 T25663 nsubj It,is
R7453 T25664 T25663 acomp unclear,is
R7454 T25665 T25666 advmod when,takes
R7455 T25666 T25663 ccomp takes,is
R7456 T25667 T25668 compound K14,cre
R7457 T25668 T25670 compound cre,induction
R7458 T25669 T25668 punct -,cre
R7459 T25670 T25666 nsubj induction,takes
R7460 T25671 T25666 advmod actually,takes
R7461 T25672 T25666 dobj place,takes
R7462 T25673 T25666 prep in,takes
R7463 T25674 T25675 det the,thymus
R7464 T25675 T25673 pobj thymus,in
R7465 T25676 T25675 amod mutant,thymus
R7466 T25677 T25663 punct ", ",is
R7467 T25678 T25663 cc but,is
R7468 T25679 T25680 mark as,were
R7469 T25680 T25700 advcl were,seems
R7470 T25681 T25682 det the,population
R7471 T25682 T25680 nsubj population,were
R7472 T25683 T25682 prep of,population
R7473 T25684 T25683 pobj cells,of
R7474 T25685 T25684 acl showing,cells
R7475 T25686 T25687 det a,staining
R7476 T25687 T25685 dobj staining,showing
R7477 T25688 T25687 amod strong,staining
R7478 T25689 T25687 amod nuclear,staining
R7479 T25690 T25691 compound β,catenin
R7480 T25691 T25687 compound catenin,staining
R7481 T25692 T25691 punct -,catenin
R7482 T25693 T25694 advmod as,as
R7483 T25694 T25682 cc as,population
R7484 T25695 T25694 advmod well,as
R7485 T25696 T25697 det the,cells
R7486 T25697 T25682 conj cells,population
R7487 T25698 T25697 acl expressing,cells
R7488 T25699 T25698 dobj K14,expressing
R7489 T25700 T25663 conj seems,is
R7490 T25701 T25680 acomp small,were
R7491 T25702 T25680 cc and,were
R7492 T25703 T25704 amod thymic,compartments
R7493 T25704 T25706 nsubj compartments,existed
R7494 T25705 T25704 amod epithelial,compartments
R7495 T25706 T25680 conj existed,were
R7496 T25707 T25706 advmod still,existed
R7497 T25708 T25706 prep in,existed
R7498 T25709 T25710 det a,thymus
R7499 T25710 T25708 pobj thymus,in
R7500 T25711 T25710 amod mild,thymus
R7501 T25712 T25710 nmod P3,thymus
R7502 T25713 T25710 amod mutant,thymus
R7503 T25714 T25715 punct (,6E
R7504 T25715 T25706 parataxis 6E,existed
R7505 T25716 T25715 compound Figure,6E
R7506 T25717 T25715 cc and,6E
R7507 T25718 T25715 conj 6F,6E
R7508 T25719 T25715 punct ),6E
R7509 T25720 T25700 punct ", ",seems
R7510 T25721 T25700 nsubj it,seems
R7511 T25722 T25723 mark that,taken
R7512 T25723 T25700 ccomp taken,seems
R7513 T25724 T25725 amod initial,differentiation
R7514 T25725 T25723 nsubj differentiation,taken
R7515 T25726 T25725 prep to,differentiation
R7516 T25727 T25728 amod medullary,TECs
R7517 T25728 T25726 pobj TECs,to
R7518 T25729 T25727 cc and,medullary
R7519 T25730 T25727 conj cortical,medullary
R7520 T25731 T25728 cc and,TECs
R7521 T25732 T25733 compound thymocyte,colonization
R7522 T25733 T25728 conj colonization,TECs
R7523 T25734 T25723 aux have,taken
R7524 T25735 T25723 advmod already,taken
R7525 T25736 T25723 dobj place,taken
R7526 T25737 T25738 amod prior,to
R7527 T25738 T25723 prep to,taken
R7528 T25739 T25740 det the,effects
R7529 T25740 T25738 pobj effects,to
R7530 T25741 T25740 amod major,effects
R7531 T25742 T25740 prep of,effects
R7532 T25743 T25744 npadvmod K14,driven
R7533 T25744 T25746 amod driven,loss
R7534 T25745 T25744 punct -,driven
R7535 T25746 T25742 pobj loss,of
R7536 T25747 T25746 compound Apc,loss
R7537 T25748 T25700 punct .,seems
R7538 T25750 T25751 advmod However,increased
R7539 T25752 T25751 punct ", ",increased
R7540 T25753 T25751 nsubj cells,increased
R7541 T25754 T25753 prep with,cells
R7542 T25755 T25756 amod nuclear,catenin
R7543 T25756 T25759 nmod catenin,cells
R7544 T25757 T25756 nmod β,catenin
R7545 T25758 T25756 punct -,catenin
R7546 T25759 T25754 pobj cells,with
R7547 T25760 T25756 cc and,catenin
R7548 T25761 T25762 npadvmod K8,positive
R7549 T25762 T25756 conj positive,catenin
R7550 T25763 T25761 punct +,K8
R7551 T25764 T25762 npadvmod K14,positive
R7552 T25765 T25764 punct +,K14
R7553 T25766 T25762 amod double,positive
R7554 T25767 T25762 punct -,positive
R7555 T25768 T25759 amod epithelial,cells
R7556 T25769 T25751 advmod subsequently,increased
R7557 T25770 T25751 punct ", ",increased
R7558 T25771 T25751 advcl associated,increased
R7559 T25772 T25771 prep with,associated
R7560 T25773 T25774 amod active,proliferation
R7561 T25774 T25772 pobj proliferation,with
R7562 T25775 T25774 prep in,proliferation
R7563 T25776 T25777 det the,group
R7564 T25777 T25775 pobj group,in
R7565 T25778 T25777 amod latter,group
R7566 T25779 T25777 prep of,group
R7567 T25780 T25779 pobj cells,of
R7568 T25781 T25774 cc and,proliferation
R7569 T25782 T25774 conj loss,proliferation
R7570 T25783 T25782 prep of,loss
R7571 T25784 T25785 compound TEC,compartments
R7572 T25785 T25783 pobj compartments,of
R7573 T25786 T25751 punct .,increased
R7574 T25788 T25789 prep With,became
R7575 T25790 T25788 pobj age,With
R7576 T25791 T25789 punct ", ",became
R7577 T25792 T25793 compound β,catenin
R7578 T25793 T25795 compound catenin,pattern
R7579 T25794 T25793 punct -,catenin
R7580 T25795 T25789 nsubj pattern,became
R7581 T25796 T25795 compound expression,pattern
R7582 T25797 T25798 advmod more,diffuse
R7583 T25798 T25789 acomp diffuse,became
R7584 T25799 T25789 cc and,became
R7585 T25800 T25801 amod fewer,cells
R7586 T25801 T25803 nsubj cells,showed
R7587 T25802 T25801 amod epithelial,cells
R7588 T25803 T25789 conj showed,became
R7589 T25804 T25805 amod nuclear,localization
R7590 T25805 T25803 dobj localization,showed
R7591 T25806 T25803 cc but,showed
R7592 T25807 T25808 nmod K8,cells
R7593 T25808 T25812 nsubj cells,remained
R7594 T25809 T25807 punct +,K8
R7595 T25810 T25808 nmod K14,cells
R7596 T25811 T25810 punct +,K14
R7597 T25812 T25803 conj remained,showed
R7598 T25813 T25812 punct ", ",remained
R7599 T25814 T25812 advcl forming,remained
R7600 T25815 T25816 amod concentric,structures
R7601 T25816 T25814 dobj structures,forming
R7602 T25817 T25816 prep of,structures
R7603 T25818 T25819 amod epithelial,cells
R7604 T25819 T25817 pobj cells,of
R7605 T25820 T25819 acl filled,cells
R7606 T25821 T25820 agent with,filled
R7607 T25822 T25823 amod hard,deposits
R7608 T25823 T25821 pobj deposits,with
R7609 T25824 T25823 compound keratin,deposits
R7610 T25825 T25820 cc and,filled
R7611 T25826 T25820 conj infiltrated,filled
R7612 T25827 T25826 agent with,infiltrated
R7613 T25828 T25829 amod vast,number
R7614 T25829 T25827 pobj number,with
R7615 T25830 T25829 prep of,number
R7616 T25831 T25830 pobj neutrophils,of
R7617 T25832 T25831 cc and,neutrophils
R7618 T25833 T25831 conj macrophages,neutrophils
R7619 T25834 T25789 punct .,became
R7620 T25836 T25837 advmod Only,cells
R7621 T25837 T25841 nsubj cells,dividing
R7622 T25838 T25837 det a,cells
R7623 T25839 T25837 amod few,cells
R7624 T25840 T25837 amod epithelial,cells
R7625 T25842 T25841 aux were,dividing
R7626 T25843 T25841 cc and,dividing
R7627 T25844 T25845 advmod hardly,thymocytes
R7628 T25845 T25847 nsubj thymocytes,were
R7629 T25846 T25845 det any,thymocytes
R7630 T25847 T25841 conj were,dividing
R7631 T25848 T25847 acomp present,were
R7632 T25849 T25847 prep by,were
R7633 T25850 T25851 det this,time
R7634 T25851 T25849 pobj time,by
R7635 T25852 T25847 punct .,were
R7636 T25854 T25855 det These,results
R7637 T25855 T25856 nsubj results,suggest
R7638 T25857 T25858 mark that,took
R7639 T25858 T25856 ccomp took,suggest
R7640 T25859 T25858 prep with,took
R7641 T25860 T25861 det the,deletion
R7642 T25861 T25859 pobj deletion,with
R7643 T25862 T25861 prep of,deletion
R7644 T25863 T25862 pobj Apc,of
R7645 T25864 T25861 prep in,deletion
R7646 T25865 T25864 pobj TECs,in
R7647 T25866 T25858 punct ", ",took
R7648 T25867 T25858 nsubj stabililization,took
R7649 T25868 T25867 cc and,stabililization
R7650 T25869 T25870 amod nuclear,localization
R7651 T25870 T25867 conj localization,stabililization
R7652 T25871 T25867 prep of,stabililization
R7653 T25872 T25873 compound β,catenin
R7654 T25873 T25871 pobj catenin,of
R7655 T25874 T25873 punct -,catenin
R7656 T25875 T25858 dobj place,took
R7657 T25876 T25858 cc and,took
R7658 T25877 T25878 advmod subsequently,differentiated
R7659 T25878 T25858 conj differentiated,took
R7660 T25879 T25880 det these,cells
R7661 T25880 T25878 nsubj cells,differentiated
R7662 T25881 T25878 prep into,differentiated
R7663 T25882 T25881 pobj keratinocytes,into
R7664 T25883 T25884 dep that,expressed
R7665 T25884 T25882 relcl expressed,keratinocytes
R7666 T25885 T25886 preconj both,K14
R7667 T25886 T25884 dobj K14,expressed
R7668 T25887 T25886 cc and,K14
R7669 T25888 T25886 conj K8,K14
R7670 T25889 T25884 punct ", ",expressed
R7671 T25890 T25884 advcl similar,expressed
R7672 T25891 T25890 prep to,similar
R7673 T25892 T25893 det the,cells
R7674 T25893 T25891 pobj cells,to
R7675 T25894 T25893 amod basal,cells
R7676 T25895 T25893 prep of,cells
R7677 T25896 T25897 det the,skin
R7678 T25897 T25895 pobj skin,of
R7679 T25898 T25884 punct ", ",expressed
R7680 T25899 T25900 advmod instead,of
R7681 T25900 T25884 prep of,expressed
R7682 T25901 T25902 compound TEC,subsets
R7683 T25902 T25900 pobj subsets,of
R7684 T25903 T25856 punct .,suggest
R7685 T25905 T25906 det The,expansion
R7686 T25906 T25907 nsubj expansion,lead
R7687 T25908 T25906 cc and,expansion
R7688 T25909 T25906 conj differentiation,expansion
R7689 T25910 T25906 prep of,expansion
R7690 T25911 T25912 det these,keratinocytes
R7691 T25912 T25910 pobj keratinocytes,of
R7692 T25913 T25907 prep to,lead
R7693 T25914 T25913 pobj loss,to
R7694 T25915 T25914 prep of,loss
R7695 T25916 T25917 amod proper,compartments
R7696 T25917 T25915 pobj compartments,of
R7697 T25918 T25917 amod thymic,compartments
R7698 T25919 T25917 amod epithelial,compartments
R7699 T25920 T25907 cc and,lead
R7700 T25921 T25922 prep in,produced
R7701 T25922 T25907 conj produced,lead
R7702 T25923 T25921 pobj turn,in
R7703 T25924 T25922 cc and,produced
R7704 T25925 T25922 conj deposited,produced
R7705 T25926 T25927 det the,keratins
R7706 T25927 T25925 dobj keratins,deposited
R7707 T25928 T25927 amod hard,keratins
R7708 T25929 T25930 dep that,caused
R7709 T25930 T25927 relcl caused,keratins
R7710 T25931 T25930 advmod consequently,caused
R7711 T25932 T25933 amod vast,amount
R7712 T25933 T25934 nsubj amount,infiltrate
R7713 T25934 T25930 ccomp infiltrate,caused
R7714 T25935 T25933 prep of,amount
R7715 T25936 T25935 pobj neutrophils,of
R7716 T25937 T25936 cc and,neutrophils
R7717 T25938 T25936 conj macrophages,neutrophils
R7718 T25939 T25934 aux to,infiltrate
R7719 T25940 T25941 det the,thymus
R7720 T25941 T25934 dobj thymus,infiltrate
R7721 T25942 T25907 punct .,lead
R7722 T25944 T25945 det These,structures
R7723 T25945 T25948 nsubj structures,overtaken
R7724 T25946 T25945 amod aberrant,structures
R7725 T25947 T25945 amod epithelial,structures
R7726 T25949 T25948 advmod eventually,overtaken
R7727 T25950 T25948 aux have,overtaken
R7728 T25951 T25952 det the,whole
R7729 T25952 T25948 dobj whole,overtaken
R7730 T25953 T25952 prep of,whole
R7731 T25954 T25955 det the,thymus
R7732 T25955 T25953 pobj thymus,of
R7733 T25956 T25948 cc and,overtaken
R7734 T25957 T25948 conj driven,overtaken
R7735 T25958 T25957 prt out,driven
R7736 T25959 T25960 det the,thymocytes
R7737 T25960 T25957 dobj thymocytes,driven
R7738 T25961 T25960 amod colonized,thymocytes
R7739 T25962 T25948 punct .,overtaken
R7740 T25964 T25965 npadvmod K14,driven
R7741 T25965 T25967 amod driven,loss
R7742 T25966 T25965 punct -,driven
R7743 T25967 T25968 nsubj loss,misdirected
R7744 T25969 T25967 prep of,loss
R7745 T25970 T25969 pobj Apc,of
R7746 T25971 T25967 cc and,loss
R7747 T25972 T25973 amod subsequent,expression
R7748 T25973 T25967 conj expression,loss
R7749 T25974 T25973 amod constitutive,expression
R7750 T25975 T25973 prep of,expression
R7751 T25976 T25977 compound β,catenin
R7752 T25977 T25975 pobj catenin,of
R7753 T25978 T25977 punct -,catenin
R7754 T25979 T25973 prep in,expression
R7755 T25980 T25979 pobj TECs,in
R7756 T25981 T25968 aux have,misdirected
R7757 T25982 T25968 advmod therefore,misdirected
R7758 T25983 T25968 dobj them,misdirected
R7759 T25984 T25968 prep to,misdirected
R7760 T25985 T25986 amod wrong,fate
R7761 T25986 T25984 pobj fate,to
R7762 T25987 T25986 amod epithelial,fate
R7763 T25988 T25986 compound cell,fate
R7764 T25989 T25968 punct ", ",misdirected
R7765 T25990 T25991 neg not,allowing
R7766 T25991 T25968 advcl allowing,misdirected
R7767 T25992 T25993 amod proper,differentiation
R7768 T25993 T25991 dobj differentiation,allowing
R7769 T25994 T25993 prep to,differentiation
R7770 T25995 T25996 preconj either,cortical
R7771 T25996 T25997 amod cortical,TECs
R7772 T25997 T25994 pobj TECs,to
R7773 T25998 T25996 cc or,cortical
R7774 T25999 T25996 conj medullary,cortical
R7775 T26000 T25993 punct ", ",differentiation
R7776 T26001 T26002 dep which,is
R7777 T26002 T25993 relcl is,differentiation
R7778 T26003 T26002 acomp essential,is
R7779 T26004 T26003 prep for,essential
R7780 T26005 T26006 amod normal,development
R7781 T26006 T26004 pobj development,for
R7782 T26007 T26006 compound thymocyte,development
R7783 T26008 T25968 punct .,misdirected
R7784 T26010 T26011 nsubj This,is
R7785 T26012 T26011 preconj not,is
R7786 T26013 T26012 advmod only,not
R7787 T26014 T26011 conj evident,is
R7788 T26015 T26014 prep from,evident
R7789 T26016 T26017 det the,lack
R7790 T26017 T26015 pobj lack,from
R7791 T26018 T26017 prep of,lack
R7792 T26019 T26020 amod dividing,thymocytes
R7793 T26020 T26018 pobj thymocytes,of
R7794 T26021 T26017 prep in,lack
R7795 T26022 T26023 det the,thymus
R7796 T26023 T26021 pobj thymus,in
R7797 T26024 T26023 amod mutant,thymus
R7798 T26025 T26017 prep by,lack
R7799 T26026 T26025 pobj P13,by
R7800 T26027 T26015 punct ", ",from
R7801 T26028 T26015 cc but,from
R7802 T26029 T26028 advmod also,but
R7803 T26030 T26015 conj by,from
R7804 T26031 T26032 det the,pattern
R7805 T26032 T26030 pobj pattern,by
R7806 T26033 T26032 amod differential,pattern
R7807 T26034 T26032 compound expression,pattern
R7808 T26035 T26032 prep of,pattern
R7809 T26036 T26035 pobj keratins,of
R7810 T26037 T26036 punct ", ",keratins
R7811 T26038 T26039 dep which,were
R7812 T26039 T26036 relcl were,keratins
R7813 T26040 T26041 advmod more,like
R7814 T26041 T26039 acomp like,were
R7815 T26042 T26041 npadvmod skin,like
R7816 T26043 T26041 punct -,like
R7817 T26044 T26041 prep than,like
R7818 T26045 T26046 npadvmod TEC,like
R7819 T26046 T26044 amod like,than
R7820 T26047 T26046 punct -,like
R7821 T26048 T26011 punct .,is
R7822 T26050 T26051 det The,importance
R7823 T26051 T26052 nsubjpass importance,demonstrated
R7824 T26053 T26051 prep of,importance
R7825 T26054 T26055 compound Apc,function
R7826 T26055 T26053 pobj function,of
R7827 T26056 T26051 prep in,importance
R7828 T26057 T26058 amod thymic,development
R7829 T26058 T26056 pobj development,in
R7830 T26059 T26052 aux has,demonstrated
R7831 T26060 T26052 auxpass been,demonstrated
R7832 T26061 T26052 agent by,demonstrated
R7833 T26062 T26063 npadvmod thymocyte,specific
R7834 T26063 T26065 amod specific,loss
R7835 T26064 T26063 punct -,specific
R7836 T26065 T26061 pobj loss,by
R7837 T26066 T26065 prep of,loss
R7838 T26067 T26066 pobj Apc,of
R7839 T26068 T26065 prep by,loss
R7840 T26069 T26068 pcomp crossing,by
R7841 T26070 T26071 det a,strain
R7842 T26071 T26069 dobj strain,crossing
R7843 T26072 T26071 amod different,strain
R7844 T26073 T26071 prep of,strain
R7845 T26074 T26075 nmod Apc,mice
R7846 T26075 T26073 pobj mice,of
R7847 T26076 T26075 amod conditional,mice
R7848 T26077 T26075 cc and,mice
R7849 T26078 T26079 nmod LckCre,mice
R7850 T26079 T26075 conj mice,mice
R7851 T26080 T26079 amod transgenic,mice
R7852 T26081 T26082 punct [,33
R7853 T26082 T26052 parataxis 33,demonstrated
R7854 T26083 T26082 punct ],33
R7855 T26084 T26052 punct .,demonstrated
R7856 T26086 T26087 advmod Here,demonstrated
R7857 T26088 T26087 punct ", ",demonstrated
R7858 T26089 T26087 prep by,demonstrated
R7859 T26090 T26091 npadvmod K14,driven
R7860 T26091 T26093 amod driven,loss
R7861 T26092 T26091 punct -,driven
R7862 T26093 T26089 pobj loss,by
R7863 T26094 T26095 npadvmod TEC,specific
R7864 T26095 T26093 amod specific,loss
R7865 T26096 T26095 punct -,specific
R7866 T26097 T26093 prep of,loss
R7867 T26098 T26097 pobj Apc,of
R7868 T26099 T26087 punct ", ",demonstrated
R7869 T26100 T26087 nsubj we,demonstrated
R7870 T26101 T26087 aux have,demonstrated
R7871 T26102 T26103 poss its,importance
R7872 T26103 T26087 dobj importance,demonstrated
R7873 T26104 T26103 prep in,importance
R7874 T26105 T26106 compound thymus,development
R7875 T26106 T26104 pobj development,in
R7876 T26107 T26108 preconj not,in
R7877 T26108 T26087 prep in,demonstrated
R7878 T26109 T26107 advmod only,not
R7879 T26110 T26108 pobj thymocytes,in
R7880 T26111 T26108 cc but,in
R7881 T26112 T26111 advmod also,but
R7882 T26113 T26108 conj in,in
R7883 T26114 T26113 pobj TECs,in
R7884 T26115 T26087 punct .,demonstrated