craft-sa-dev Home  

PMC:1564426 / 43939-46074 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T23116 0-5 IN denotes While
T23118 6-10 DT denotes some
T23119 11-19 NNS denotes features
T23120 20-22 IN denotes of
T23121 23-26 PRP$ denotes our
T23123 27-33 JJ denotes mutant
T23122 34-38 NNS denotes mice
T23117 39-43 VBD denotes were
T23125 44-51 JJ denotes similar
T23126 52-54 IN denotes to
T23127 55-60 DT denotes these
T23129 61-71 JJ denotes transgenic
T23128 72-76 NNS denotes mice
T23130 76-78 , denotes ,
T23131 78-83 JJ denotes other
T23133 84-94 JJ denotes phenotypic
T23132 95-102 NNS denotes aspects
T23124 103-107 VBD denotes were
T23134 108-115 RB denotes largely
T23135 116-124 JJ denotes distinct
T23136 124-125 . denotes .
T23137 125-360 sentence denotes In addition to aberrant hair follicle morphogenesis, K14-driven loss of Apc caused formation of multiple tooth buds that, like hair follicles, were known to develop through inductive interactions between the epithelium and mesenchyme.
T23138 126-128 IN denotes In
T23140 129-137 NN denotes addition
T23141 138-140 IN denotes to
T23142 141-149 JJ denotes aberrant
T23144 150-154 NN denotes hair
T23145 155-163 NN denotes follicle
T23143 164-177 NN denotes morphogenesis
T23146 177-179 , denotes ,
T23147 179-182 NN denotes K14
T23149 182-183 HYPH denotes -
T23148 183-189 JJ denotes driven
T23150 190-194 NN denotes loss
T23151 195-197 IN denotes of
T23152 198-201 NN denotes Apc
T23139 202-208 VBD denotes caused
T23153 209-218 NN denotes formation
T23154 219-221 IN denotes of
T23155 222-230 JJ denotes multiple
T23157 231-236 NN denotes tooth
T23156 237-241 NNS denotes buds
T23158 242-246 WDT denotes that
T23160 246-248 , denotes ,
T23161 248-252 IN denotes like
T23162 253-257 NN denotes hair
T23163 258-267 NNS denotes follicles
T23164 267-269 , denotes ,
T23165 269-273 VBD denotes were
T23159 274-279 VBN denotes known
T23166 280-282 TO denotes to
T23167 283-290 VB denotes develop
T23168 291-298 IN denotes through
T23169 299-308 JJ denotes inductive
T23170 309-321 NNS denotes interactions
T23171 322-329 IN denotes between
T23172 330-333 DT denotes the
T23173 334-344 NN denotes epithelium
T23174 345-348 CC denotes and
T23175 349-359 NN denotes mesenchyme
T23176 359-360 . denotes .
T23177 360-692 sentence denotes This observation was similar to the ectopic tooth buds found in animals misexpressing Lef1 [27], but more severe and was also present at birth, indicating the effect of Apc loss during the initiation of embryonic tooth development, which was evident by aberrant Shh expression in E15.5 embryonic oral epithelium (unpublished data).
T23178 361-365 DT denotes This
T23179 366-377 NN denotes observation
T23180 378-381 VBD denotes was
T23181 382-389 JJ denotes similar
T23182 390-392 IN denotes to
T23183 393-396 DT denotes the
T23185 397-404 JJ denotes ectopic
T23186 405-410 NN denotes tooth
T23184 411-415 NNS denotes buds
T23187 416-421 VBN denotes found
T23188 422-424 IN denotes in
T23189 425-432 NNS denotes animals
T23190 433-446 VBG denotes misexpressing
T23191 447-451 NN denotes Lef1
T23192 452-453 -LRB- denotes [
T23193 453-455 CD denotes 27
T23194 455-456 -RRB- denotes ]
T23195 456-458 , denotes ,
T23196 458-461 CC denotes but
T23197 462-466 RBR denotes more
T23198 467-473 JJ denotes severe
T23199 474-477 CC denotes and
T23200 478-481 VBD denotes was
T23201 482-486 RB denotes also
T23202 487-494 JJ denotes present
T23203 495-497 IN denotes at
T23204 498-503 NN denotes birth
T23205 503-505 , denotes ,
T23206 505-515 VBG denotes indicating
T23207 516-519 DT denotes the
T23208 520-526 NN denotes effect
T23209 527-529 IN denotes of
T23210 530-533 NN denotes Apc
T23211 534-538 NN denotes loss
T23212 539-545 IN denotes during
T23213 546-549 DT denotes the
T23214 550-560 NN denotes initiation
T23215 561-563 IN denotes of
T23216 564-573 JJ denotes embryonic
T23218 574-579 NN denotes tooth
T23217 580-591 NN denotes development
T23219 591-593 , denotes ,
T23220 593-598 WDT denotes which
T23221 599-602 VBD denotes was
T23222 603-610 JJ denotes evident
T23223 611-613 IN denotes by
T23224 614-622 JJ denotes aberrant
T23226 623-626 NN denotes Shh
T23225 627-637 NN denotes expression
T23227 638-640 IN denotes in
T23228 641-646 NN denotes E15.5
T23230 647-656 JJ denotes embryonic
T23231 657-661 JJ denotes oral
T23229 662-672 NN denotes epithelium
T23232 673-674 -LRB- denotes (
T23234 674-685 JJ denotes unpublished
T23233 686-690 NNS denotes data
T23235 690-691 -RRB- denotes )
T23236 691-692 . denotes .
T23237 692-864 sentence denotes It should be noted that although multiple tooth buds were histologically visible (Figure 4O and 4P), these teeth never broke out and the KA mutant mice appeared toothless.
T23238 693-695 PRP denotes It
T23240 696-702 MD denotes should
T23241 703-705 VB denotes be
T23239 706-711 VBN denotes noted
T23242 712-716 IN denotes that
T23244 717-725 IN denotes although
T23246 726-734 JJ denotes multiple
T23248 735-740 NN denotes tooth
T23247 741-745 NNS denotes buds
T23245 746-750 VBD denotes were
T23249 751-765 RB denotes histologically
T23250 766-773 JJ denotes visible
T23251 774-775 -LRB- denotes (
T23253 775-781 NN denotes Figure
T23252 782-784 NN denotes 4O
T23254 785-788 CC denotes and
T23255 789-791 NN denotes 4P
T23256 791-792 -RRB- denotes )
T23257 792-794 , denotes ,
T23258 794-799 DT denotes these
T23259 800-805 NNS denotes teeth
T23260 806-811 RB denotes never
T23243 812-817 VBD denotes broke
T23261 818-821 RP denotes out
T23262 822-825 CC denotes and
T23263 826-829 DT denotes the
T23265 830-832 NN denotes KA
T23266 833-839 JJ denotes mutant
T23264 840-844 NNS denotes mice
T23267 845-853 VBD denotes appeared
T23268 854-863 JJ denotes toothless
T23269 863-864 . denotes .
T23270 864-929 sentence denotes This unusual severe tooth defect is unique to these mutant mice.
T23271 865-869 DT denotes This
T23273 870-877 JJ denotes unusual
T23274 878-884 JJ denotes severe
T23275 885-890 NN denotes tooth
T23272 891-897 NN denotes defect
T23276 898-900 VBZ denotes is
T23277 901-907 JJ denotes unique
T23278 908-910 IN denotes to
T23279 911-916 DT denotes these
T23281 917-923 JJ denotes mutant
T23280 924-928 NNS denotes mice
T23282 928-929 . denotes .
T23283 929-1026 sentence denotes In addition, neither of the two transgenic mice was postnatally lethal as in the KA mutant mice.
T23284 930-932 IN denotes In
T23286 933-941 NN denotes addition
T23287 941-943 , denotes ,
T23288 943-950 DT denotes neither
T23289 951-953 IN denotes of
T23290 954-957 DT denotes the
T23292 958-961 CD denotes two
T23293 962-972 JJ denotes transgenic
T23291 973-977 NNS denotes mice
T23285 978-981 VBD denotes was
T23294 982-993 RB denotes postnatally
T23295 994-1000 JJ denotes lethal
T23296 1001-1003 IN denotes as
T23297 1004-1006 IN denotes in
T23298 1007-1010 DT denotes the
T23300 1011-1013 NN denotes KA
T23301 1014-1020 JJ denotes mutant
T23299 1021-1025 NNS denotes mice
T23302 1025-1026 . denotes .
T23303 1026-1160 sentence denotes We did not find any obvious histopathological abnormalities in the internal organs of KA mice that could contribute to the lethality.
T23304 1027-1029 PRP denotes We
T23306 1030-1033 VBD denotes did
T23307 1034-1037 RB denotes not
T23305 1038-1042 VB denotes find
T23308 1043-1046 DT denotes any
T23310 1047-1054 JJ denotes obvious
T23311 1055-1072 JJ denotes histopathological
T23309 1073-1086 NNS denotes abnormalities
T23312 1087-1089 IN denotes in
T23313 1090-1093 DT denotes the
T23315 1094-1102 JJ denotes internal
T23314 1103-1109 NNS denotes organs
T23316 1110-1112 IN denotes of
T23317 1113-1115 NN denotes KA
T23318 1116-1120 NNS denotes mice
T23319 1121-1125 WDT denotes that
T23321 1126-1131 MD denotes could
T23320 1132-1142 VB denotes contribute
T23322 1143-1145 IN denotes to
T23323 1146-1149 DT denotes the
T23324 1150-1159 NN denotes lethality
T23325 1159-1160 . denotes .
T23326 1160-1342 sentence denotes However, the fact that all the mutants had lower weight (Figure 2F) with hardly any evidence of solid food in their stomach indicates that the mutants might have died of starvation.
T23327 1161-1168 RB denotes However
T23329 1168-1170 , denotes ,
T23330 1170-1173 DT denotes the
T23331 1174-1178 NN denotes fact
T23332 1179-1183 IN denotes that
T23334 1184-1187 PDT denotes all
T23336 1188-1191 DT denotes the
T23335 1192-1199 NNS denotes mutants
T23333 1200-1203 VBD denotes had
T23337 1204-1209 JJR denotes lower
T23338 1210-1216 NN denotes weight
T23339 1217-1218 -LRB- denotes (
T23341 1218-1224 NN denotes Figure
T23340 1225-1227 NN denotes 2F
T23342 1227-1228 -RRB- denotes )
T23343 1229-1233 IN denotes with
T23344 1234-1240 RB denotes hardly
T23346 1241-1244 DT denotes any
T23345 1245-1253 NN denotes evidence
T23347 1254-1256 IN denotes of
T23348 1257-1262 JJ denotes solid
T23349 1263-1267 NN denotes food
T23350 1268-1270 IN denotes in
T23351 1271-1276 PRP$ denotes their
T23352 1277-1284 NN denotes stomach
T23328 1285-1294 VBZ denotes indicates
T23353 1295-1299 IN denotes that
T23355 1300-1303 DT denotes the
T23356 1304-1311 NNS denotes mutants
T23357 1312-1317 MD denotes might
T23358 1318-1322 VB denotes have
T23354 1323-1327 VBN denotes died
T23359 1328-1330 IN denotes of
T23360 1331-1341 NN denotes starvation
T23361 1341-1342 . denotes .
T23362 1342-1461 sentence denotes Dermal fat was reduced in the mutant skin, possibly as a consequence of poor nutrition caused by the absence of teeth.
T23363 1343-1349 JJ denotes Dermal
T23364 1350-1353 NN denotes fat
T23366 1354-1357 VBD denotes was
T23365 1358-1365 VBN denotes reduced
T23367 1366-1368 IN denotes in
T23368 1369-1372 DT denotes the
T23370 1373-1379 JJ denotes mutant
T23369 1380-1384 NN denotes skin
T23371 1384-1386 , denotes ,
T23372 1386-1394 RB denotes possibly
T23373 1395-1397 IN denotes as
T23374 1398-1399 DT denotes a
T23375 1400-1411 NN denotes consequence
T23376 1412-1414 IN denotes of
T23377 1415-1419 JJ denotes poor
T23378 1420-1429 NN denotes nutrition
T23379 1430-1436 VBN denotes caused
T23380 1437-1439 IN denotes by
T23381 1440-1443 DT denotes the
T23382 1444-1451 NN denotes absence
T23383 1452-1454 IN denotes of
T23384 1455-1460 NNS denotes teeth
T23385 1460-1461 . denotes .
T23386 1461-1674 sentence denotes Since the weight loss in KA mutants started from P8–P10 while pups were still nursed by their mothers, starvation due to lack of teeth cannot be the sole cause of death, but is likely to be a contributing factor.
T23387 1462-1467 IN denotes Since
T23389 1468-1471 DT denotes the
T23391 1472-1478 NN denotes weight
T23390 1479-1483 NN denotes loss
T23392 1484-1486 IN denotes in
T23393 1487-1489 NN denotes KA
T23394 1490-1497 NNS denotes mutants
T23388 1498-1505 VBN denotes started
T23396 1506-1510 IN denotes from
T23397 1511-1513 NN denotes P8
T23398 1513-1514 SYM denotes –
T23399 1514-1517 NN denotes P10
T23400 1518-1523 IN denotes while
T23402 1524-1528 NNS denotes pups
T23403 1529-1533 VBD denotes were
T23404 1534-1539 RB denotes still
T23401 1540-1546 VBN denotes nursed
T23405 1547-1549 IN denotes by
T23406 1550-1555 PRP$ denotes their
T23407 1556-1563 NNS denotes mothers
T23408 1563-1565 , denotes ,
T23409 1565-1575 NN denotes starvation
T23410 1576-1579 IN denotes due
T23411 1580-1582 IN denotes to
T23412 1583-1587 NN denotes lack
T23413 1588-1590 IN denotes of
T23414 1591-1596 NNS denotes teeth
T23415 1597-1600 MD denotes can
T23416 1600-1603 RB denotes not
T23395 1604-1606 VB denotes be
T23417 1607-1610 DT denotes the
T23419 1611-1615 JJ denotes sole
T23418 1616-1621 NN denotes cause
T23420 1622-1624 IN denotes of
T23421 1625-1630 NN denotes death
T23422 1630-1632 , denotes ,
T23423 1632-1635 CC denotes but
T23424 1636-1638 VBZ denotes is
T23425 1639-1645 JJ denotes likely
T23426 1646-1648 TO denotes to
T23427 1649-1651 VB denotes be
T23428 1652-1653 DT denotes a
T23430 1654-1666 VBG denotes contributing
T23429 1667-1673 NN denotes factor
T23431 1673-1674 . denotes .
T23432 1674-1871 sentence denotes Absence of teeth and mammary glands have been observed in mice deficient in Lef1 and ectopically expressing Dkk1 [29,30] but their absence was due to the block in development before the bud stage.
T23433 1675-1682 NN denotes Absence
T23435 1683-1685 IN denotes of
T23436 1686-1691 NNS denotes teeth
T23437 1692-1695 CC denotes and
T23438 1696-1703 JJ denotes mammary
T23439 1704-1710 NNS denotes glands
T23440 1711-1715 VBP denotes have
T23441 1716-1720 VBN denotes been
T23434 1721-1729 VBN denotes observed
T23442 1730-1732 IN denotes in
T23443 1733-1737 NNS denotes mice
T23444 1738-1747 JJ denotes deficient
T23445 1748-1750 IN denotes in
T23446 1751-1755 NN denotes Lef1
T23447 1756-1759 CC denotes and
T23448 1760-1771 RB denotes ectopically
T23449 1772-1782 VBG denotes expressing
T23450 1783-1787 NN denotes Dkk1
T23451 1788-1789 -LRB- denotes [
T23453 1789-1791 CD denotes 29
T23454 1791-1792 , denotes ,
T23452 1792-1794 CD denotes 30
T23455 1794-1795 -RRB- denotes ]
T23456 1796-1799 CC denotes but
T23457 1800-1805 PRP$ denotes their
T23458 1806-1813 NN denotes absence
T23459 1814-1817 VBD denotes was
T23460 1818-1821 IN denotes due
T23461 1822-1824 IN denotes to
T23462 1825-1828 DT denotes the
T23463 1829-1834 NN denotes block
T23464 1835-1837 IN denotes in
T23465 1838-1849 NN denotes development
T23466 1850-1856 IN denotes before
T23467 1857-1860 DT denotes the
T23469 1861-1864 NN denotes bud
T23468 1865-1870 NN denotes stage
T23470 1870-1871 . denotes .
T23471 1871-2009 sentence denotes Hence, neither loss nor excess of tooth bud formation allows proper development of teeth for mice to have a healthy diet and normal life.
T23472 1872-1877 RB denotes Hence
T23474 1877-1879 , denotes ,
T23475 1879-1886 CC denotes neither
T23476 1887-1891 NN denotes loss
T23477 1892-1895 CC denotes nor
T23478 1896-1902 NN denotes excess
T23479 1903-1905 IN denotes of
T23480 1906-1911 JJ denotes tooth
T23481 1912-1915 NN denotes bud
T23482 1916-1925 NN denotes formation
T23473 1926-1932 VBZ denotes allows
T23483 1933-1939 JJ denotes proper
T23484 1940-1951 NN denotes development
T23485 1952-1954 IN denotes of
T23486 1955-1960 NNS denotes teeth
T23487 1961-1964 IN denotes for
T23489 1965-1969 NNS denotes mice
T23490 1970-1972 TO denotes to
T23488 1973-1977 VB denotes have
T23491 1978-1979 DT denotes a
T23493 1980-1987 JJ denotes healthy
T23492 1988-1992 NN denotes diet
T23494 1993-1996 CC denotes and
T23495 1997-2003 JJ denotes normal
T23496 2004-2008 NN denotes life
T23497 2008-2009 . denotes .
T23498 2009-2135 sentence denotes Mechanistic studies to understand how increased levels of β-catenin leads to altered skin and tooth phenotypes are under way.
T23499 2010-2021 JJ denotes Mechanistic
T23500 2022-2029 NNS denotes studies
T23502 2030-2032 TO denotes to
T23503 2033-2043 VB denotes understand
T23504 2044-2047 WRB denotes how
T23506 2048-2057 VBN denotes increased
T23507 2058-2064 NNS denotes levels
T23508 2065-2067 IN denotes of
T23509 2068-2069 NN denotes β
T23511 2069-2070 HYPH denotes -
T23510 2070-2077 NN denotes catenin
T23505 2078-2083 VBZ denotes leads
T23512 2084-2086 IN denotes to
T23513 2087-2094 JJ denotes altered
T23515 2095-2099 NN denotes skin
T23516 2100-2103 CC denotes and
T23517 2104-2109 NN denotes tooth
T23514 2110-2120 NNS denotes phenotypes
T23501 2121-2124 VBP denotes are
T23518 2125-2130 IN denotes under
T23519 2131-2134 NN denotes way
T23520 2134-2135 . denotes .
R6837 T23116 T23117 mark While,were
R6838 T23117 T23124 advcl were,were
R6839 T23118 T23119 det some,features
R6840 T23119 T23117 nsubj features,were
R6841 T23120 T23119 prep of,features
R6842 T23121 T23122 poss our,mice
R6843 T23122 T23120 pobj mice,of
R6844 T23123 T23122 amod mutant,mice
R6845 T23125 T23117 acomp similar,were
R6846 T23126 T23125 prep to,similar
R6847 T23127 T23128 det these,mice
R6848 T23128 T23126 pobj mice,to
R6849 T23129 T23128 amod transgenic,mice
R6850 T23130 T23124 punct ", ",were
R6851 T23131 T23132 amod other,aspects
R6852 T23132 T23124 nsubj aspects,were
R6853 T23133 T23132 amod phenotypic,aspects
R6854 T23134 T23135 advmod largely,distinct
R6855 T23135 T23124 acomp distinct,were
R6856 T23136 T23124 punct .,were
R6857 T23138 T23139 prep In,caused
R6858 T23140 T23138 pobj addition,In
R6859 T23141 T23140 prep to,addition
R6860 T23142 T23143 amod aberrant,morphogenesis
R6861 T23143 T23141 pobj morphogenesis,to
R6862 T23144 T23145 compound hair,follicle
R6863 T23145 T23143 compound follicle,morphogenesis
R6864 T23146 T23139 punct ", ",caused
R6865 T23147 T23148 npadvmod K14,driven
R6866 T23148 T23150 amod driven,loss
R6867 T23149 T23148 punct -,driven
R6868 T23150 T23139 nsubj loss,caused
R6869 T23151 T23150 prep of,loss
R6870 T23152 T23151 pobj Apc,of
R6871 T23153 T23139 dobj formation,caused
R6872 T23154 T23153 prep of,formation
R6873 T23155 T23156 amod multiple,buds
R6874 T23156 T23154 pobj buds,of
R6875 T23157 T23156 compound tooth,buds
R6876 T23158 T23159 dep that,known
R6877 T23159 T23156 relcl known,buds
R6878 T23160 T23159 punct ", ",known
R6879 T23161 T23159 prep like,known
R6880 T23162 T23163 compound hair,follicles
R6881 T23163 T23161 pobj follicles,like
R6882 T23164 T23159 punct ", ",known
R6883 T23165 T23159 auxpass were,known
R6884 T23166 T23167 aux to,develop
R6885 T23167 T23159 xcomp develop,known
R6886 T23168 T23167 prep through,develop
R6887 T23169 T23170 amod inductive,interactions
R6888 T23170 T23168 pobj interactions,through
R6889 T23171 T23170 prep between,interactions
R6890 T23172 T23173 det the,epithelium
R6891 T23173 T23171 pobj epithelium,between
R6892 T23174 T23173 cc and,epithelium
R6893 T23175 T23173 conj mesenchyme,epithelium
R6894 T23176 T23139 punct .,caused
R6895 T23178 T23179 det This,observation
R6896 T23179 T23180 nsubj observation,was
R6897 T23181 T23180 acomp similar,was
R6898 T23182 T23181 prep to,similar
R6899 T23183 T23184 det the,buds
R6900 T23184 T23182 pobj buds,to
R6901 T23185 T23184 amod ectopic,buds
R6902 T23186 T23184 compound tooth,buds
R6903 T23187 T23184 acl found,buds
R6904 T23188 T23187 prep in,found
R6905 T23189 T23188 pobj animals,in
R6906 T23190 T23189 acl misexpressing,animals
R6907 T23191 T23190 dobj Lef1,misexpressing
R6908 T23192 T23193 punct [,27
R6909 T23193 T23187 parataxis 27,found
R6910 T23194 T23193 punct ],27
R6911 T23195 T23181 punct ", ",similar
R6912 T23196 T23181 cc but,similar
R6913 T23197 T23198 advmod more,severe
R6914 T23198 T23181 conj severe,similar
R6915 T23199 T23180 cc and,was
R6916 T23200 T23180 conj was,was
R6917 T23201 T23200 advmod also,was
R6918 T23202 T23200 acomp present,was
R6919 T23203 T23200 prep at,was
R6920 T23204 T23203 pobj birth,at
R6921 T23205 T23200 punct ", ",was
R6922 T23206 T23200 advcl indicating,was
R6923 T23207 T23208 det the,effect
R6924 T23208 T23206 dobj effect,indicating
R6925 T23209 T23208 prep of,effect
R6926 T23210 T23211 compound Apc,loss
R6927 T23211 T23209 pobj loss,of
R6928 T23212 T23211 prep during,loss
R6929 T23213 T23214 det the,initiation
R6930 T23214 T23212 pobj initiation,during
R6931 T23215 T23214 prep of,initiation
R6932 T23216 T23217 amod embryonic,development
R6933 T23217 T23215 pobj development,of
R6934 T23218 T23217 compound tooth,development
R6935 T23219 T23208 punct ", ",effect
R6936 T23220 T23221 dep which,was
R6937 T23221 T23208 relcl was,effect
R6938 T23222 T23221 acomp evident,was
R6939 T23223 T23221 prep by,was
R6940 T23224 T23225 amod aberrant,expression
R6941 T23225 T23223 pobj expression,by
R6942 T23226 T23225 compound Shh,expression
R6943 T23227 T23225 prep in,expression
R6944 T23228 T23229 nmod E15.5,epithelium
R6945 T23229 T23227 pobj epithelium,in
R6946 T23230 T23229 amod embryonic,epithelium
R6947 T23231 T23229 amod oral,epithelium
R6948 T23232 T23233 punct (,data
R6949 T23233 T23206 meta data,indicating
R6950 T23234 T23233 amod unpublished,data
R6951 T23235 T23233 punct ),data
R6952 T23236 T23180 punct .,was
R6953 T23238 T23239 nsubjpass It,noted
R6954 T23240 T23239 aux should,noted
R6955 T23241 T23239 auxpass be,noted
R6956 T23242 T23243 mark that,broke
R6957 T23243 T23239 ccomp broke,noted
R6958 T23244 T23245 mark although,were
R6959 T23245 T23243 advcl were,broke
R6960 T23246 T23247 amod multiple,buds
R6961 T23247 T23245 nsubj buds,were
R6962 T23248 T23247 compound tooth,buds
R6963 T23249 T23250 advmod histologically,visible
R6964 T23250 T23245 acomp visible,were
R6965 T23251 T23252 punct (,4O
R6966 T23252 T23245 parataxis 4O,were
R6967 T23253 T23252 compound Figure,4O
R6968 T23254 T23252 cc and,4O
R6969 T23255 T23252 conj 4P,4O
R6970 T23256 T23252 punct ),4O
R6971 T23257 T23243 punct ", ",broke
R6972 T23258 T23259 det these,teeth
R6973 T23259 T23243 nsubj teeth,broke
R6974 T23260 T23243 neg never,broke
R6975 T23261 T23243 prt out,broke
R6976 T23262 T23243 cc and,broke
R6977 T23263 T23264 det the,mice
R6978 T23264 T23267 nsubj mice,appeared
R6979 T23265 T23264 nmod KA,mice
R6980 T23266 T23264 amod mutant,mice
R6981 T23267 T23243 conj appeared,broke
R6982 T23268 T23267 oprd toothless,appeared
R6983 T23375 T23373 pobj consequence,as
R6984 T23376 T23375 prep of,consequence
R6985 T23377 T23378 amod poor,nutrition
R6986 T23378 T23376 pobj nutrition,of
R6987 T23379 T23378 acl caused,nutrition
R6988 T23380 T23379 agent by,caused
R6989 T23381 T23382 det the,absence
R6990 T23269 T23239 punct .,noted
R6991 T23382 T23380 pobj absence,by
R6992 T23383 T23382 prep of,absence
R6993 T23271 T23272 det This,defect
R6994 T23384 T23383 pobj teeth,of
R6995 T23385 T23365 punct .,reduced
R6996 T23272 T23276 nsubj defect,is
R6997 T23273 T23272 amod unusual,defect
R6998 T23387 T23388 mark Since,started
R6999 T23274 T23272 amod severe,defect
R7000 T23275 T23272 compound tooth,defect
R7001 T23388 T23395 advcl started,be
R7002 T23277 T23276 acomp unique,is
R7003 T23278 T23277 prep to,unique
R7004 T23279 T23280 det these,mice
R7005 T23389 T23390 det the,loss
R7006 T23280 T23278 pobj mice,to
R7007 T23281 T23280 amod mutant,mice
R7008 T23390 T23388 nsubj loss,started
R7009 T23282 T23276 punct .,is
R7010 T23284 T23285 prep In,was
R7011 T23391 T23390 compound weight,loss
R7012 T23392 T23390 prep in,loss
R7013 T23286 T23284 pobj addition,In
R7014 T23287 T23285 punct ", ",was
R7015 T23393 T23394 compound KA,mutants
R7016 T23288 T23285 nsubj neither,was
R7017 T23289 T23288 prep of,neither
R7018 T23290 T23291 det the,mice
R7019 T23394 T23392 pobj mutants,in
R7020 T23291 T23289 pobj mice,of
R7021 T23292 T23291 nummod two,mice
R7022 T23293 T23291 amod transgenic,mice
R7023 T23396 T23388 prep from,started
R7024 T23294 T23295 advmod postnatally,lethal
R7025 T23295 T23285 acomp lethal,was
R7026 T23296 T23285 prep as,was
R7027 T23297 T23296 prep in,as
R7028 T23298 T23299 det the,mice
R7029 T23299 T23297 pobj mice,in
R7030 T23397 T23396 pobj P8,from
R7031 T23300 T23299 nmod KA,mice
R7032 T23301 T23299 amod mutant,mice
R7033 T23302 T23285 punct .,was
R7034 T23398 T23399 punct –,P10
R7035 T23399 T23397 prep P10,P8
R7036 T23304 T23305 nsubj We,find
R7037 T23306 T23305 aux did,find
R7038 T23307 T23305 neg not,find
R7039 T23308 T23309 det any,abnormalities
R7040 T23400 T23401 mark while,nursed
R7041 T23309 T23305 dobj abnormalities,find
R7042 T23310 T23309 amod obvious,abnormalities
R7043 T23311 T23309 amod histopathological,abnormalities
R7044 T23312 T23309 prep in,abnormalities
R7045 T23401 T23388 advcl nursed,started
R7046 T23313 T23314 det the,organs
R7047 T23314 T23312 pobj organs,in
R7048 T23315 T23314 amod internal,organs
R7049 T23402 T23401 nsubjpass pups,nursed
R7050 T23316 T23314 prep of,organs
R7051 T23317 T23318 compound KA,mice
R7052 T23318 T23316 pobj mice,of
R7053 T23403 T23401 auxpass were,nursed
R7054 T23319 T23320 dep that,contribute
R7055 T23320 T23309 relcl contribute,abnormalities
R7056 T23321 T23320 aux could,contribute
R7057 T23404 T23401 advmod still,nursed
R7058 T23322 T23320 prep to,contribute
R7059 T23323 T23324 det the,lethality
R7060 T23405 T23401 agent by,nursed
R7061 T23324 T23322 pobj lethality,to
R7062 T23325 T23305 punct .,find
R7063 T23406 T23407 poss their,mothers
R7064 T23327 T23328 advmod However,indicates
R7065 T23407 T23405 pobj mothers,by
R7066 T23329 T23328 punct ", ",indicates
R7067 T23330 T23331 det the,fact
R7068 T23331 T23328 nsubj fact,indicates
R7069 T23408 T23395 punct ", ",be
R7070 T23332 T23333 mark that,had
R7071 T23333 T23331 acl had,fact
R7072 T23334 T23335 predet all,mutants
R7073 T23409 T23395 nsubj starvation,be
R7074 T23335 T23333 nsubj mutants,had
R7075 T23336 T23335 det the,mutants
R7076 T23337 T23338 amod lower,weight
R7077 T23338 T23333 dobj weight,had
R7078 T23339 T23340 punct (,2F
R7079 T23340 T23338 parataxis 2F,weight
R7080 T23410 T23409 prep due,starvation
R7081 T23341 T23340 compound Figure,2F
R7082 T23342 T23340 punct ),2F
R7083 T23343 T23338 prep with,weight
R7084 T23411 T23410 pcomp to,due
R7085 T23344 T23345 advmod hardly,evidence
R7086 T23345 T23343 pobj evidence,with
R7087 T23412 T23410 pobj lack,due
R7088 T23346 T23345 det any,evidence
R7089 T23347 T23345 prep of,evidence
R7090 T23348 T23349 amod solid,food
R7091 T23349 T23347 pobj food,of
R7092 T23413 T23412 prep of,lack
R7093 T23350 T23345 prep in,evidence
R7094 T23351 T23352 poss their,stomach
R7095 T23352 T23350 pobj stomach,in
R7096 T23414 T23413 pobj teeth,of
R7097 T23353 T23354 mark that,died
R7098 T23354 T23328 ccomp died,indicates
R7099 T23355 T23356 det the,mutants
R7100 T23415 T23395 aux can,be
R7101 T23356 T23354 nsubj mutants,died
R7102 T23357 T23354 aux might,died
R7103 T23358 T23354 aux have,died
R7104 T23416 T23395 neg not,be
R7105 T23359 T23354 prep of,died
R7106 T23360 T23359 pobj starvation,of
R7107 T23361 T23328 punct .,indicates
R7108 T23417 T23418 det the,cause
R7109 T23418 T23395 attr cause,be
R7110 T23363 T23364 amod Dermal,fat
R7111 T23419 T23418 amod sole,cause
R7112 T23364 T23365 nsubjpass fat,reduced
R7113 T23420 T23418 prep of,cause
R7114 T23366 T23365 auxpass was,reduced
R7115 T23367 T23365 prep in,reduced
R7116 T23421 T23420 pobj death,of
R7117 T23368 T23369 det the,skin
R7118 T23369 T23367 pobj skin,in
R7119 T23370 T23369 amod mutant,skin
R7120 T23422 T23395 punct ", ",be
R7121 T23371 T23365 punct ", ",reduced
R7122 T23372 T23373 advmod possibly,as
R7123 T23423 T23395 cc but,be
R7124 T23373 T23365 prep as,reduced
R7125 T23374 T23375 det a,consequence
R7126 T23424 T23395 conj is,be
R7127 T23425 T23424 acomp likely,is
R7128 T23426 T23427 aux to,be
R7129 T23427 T23425 xcomp be,likely
R7130 T23428 T23429 det a,factor
R7131 T23481 T23482 compound bud,formation
R7132 T23482 T23479 pobj formation,of
R7133 T23483 T23484 amod proper,development
R7134 T23429 T23427 attr factor,be
R7135 T23484 T23473 dobj development,allows
R7136 T23485 T23484 prep of,development
R7137 T23486 T23485 pobj teeth,of
R7138 T23430 T23429 amod contributing,factor
R7139 T23487 T23488 mark for,have
R7140 T23488 T23473 advcl have,allows
R7141 T23489 T23488 nsubj mice,have
R7142 T23431 T23395 punct .,be
R7143 T23490 T23488 aux to,have
R7144 T23491 T23492 det a,diet
R7145 T23433 T23434 nsubjpass Absence,observed
R7146 T23492 T23488 dobj diet,have
R7147 T23493 T23492 amod healthy,diet
R7148 T23494 T23492 cc and,diet
R7149 T23435 T23433 prep of,Absence
R7150 T23495 T23496 amod normal,life
R7151 T23496 T23492 conj life,diet
R7152 T23497 T23473 punct .,allows
R7153 T23499 T23500 amod Mechanistic,studies
R7154 T23436 T23435 pobj teeth,of
R7155 T23500 T23501 nsubj studies,are
R7156 T23437 T23436 cc and,teeth
R7157 T23502 T23503 aux to,understand
R7158 T23503 T23500 advcl understand,studies
R7159 T23504 T23505 advmod how,leads
R7160 T23438 T23439 amod mammary,glands
R7161 T23505 T23503 ccomp leads,understand
R7162 T23506 T23507 amod increased,levels
R7163 T23507 T23505 nsubj levels,leads
R7164 T23439 T23436 conj glands,teeth
R7165 T23508 T23507 prep of,levels
R7166 T23509 T23510 compound β,catenin
R7167 T23440 T23434 aux have,observed
R7168 T23510 T23508 pobj catenin,of
R7169 T23511 T23510 punct -,catenin
R7170 T23512 T23505 prep to,leads
R7171 T23441 T23434 auxpass been,observed
R7172 T23513 T23514 amod altered,phenotypes
R7173 T23514 T23512 pobj phenotypes,to
R7174 T23515 T23514 nmod skin,phenotypes
R7175 T23442 T23434 prep in,observed
R7176 T23516 T23515 cc and,skin
R7177 T23517 T23515 conj tooth,skin
R7178 T23518 T23501 prep under,are
R7179 T23443 T23442 pobj mice,in
R7180 T23519 T23518 pobj way,under
R7181 T23520 T23501 punct .,are
R7182 T23444 T23443 amod deficient,mice
R7183 T23445 T23444 prep in,deficient
R7184 T23446 T23445 pobj Lef1,in
R7185 T23447 T23444 cc and,deficient
R7186 T23448 T23449 advmod ectopically,expressing
R7187 T23449 T23444 conj expressing,deficient
R7188 T23450 T23449 dobj Dkk1,expressing
R7189 T23451 T23452 punct [,30
R7190 T23452 T23434 parataxis 30,observed
R7191 T23453 T23452 nummod 29,30
R7192 T23454 T23452 punct ",",30
R7193 T23455 T23452 punct ],30
R7194 T23456 T23434 cc but,observed
R7195 T23457 T23458 poss their,absence
R7196 T23458 T23459 nsubj absence,was
R7197 T23459 T23434 conj was,observed
R7198 T23460 T23459 prep due,was
R7199 T23461 T23460 pcomp to,due
R7200 T23462 T23463 det the,block
R7201 T23463 T23460 pobj block,due
R7202 T23464 T23463 prep in,block
R7203 T23465 T23464 pobj development,in
R7204 T23466 T23463 prep before,block
R7205 T23467 T23468 det the,stage
R7206 T23468 T23466 pobj stage,before
R7207 T23469 T23468 compound bud,stage
R7208 T23470 T23459 punct .,was
R7209 T23472 T23473 advmod Hence,allows
R7210 T23474 T23473 punct ", ",allows
R7211 T23475 T23476 preconj neither,loss
R7212 T23476 T23473 nsubj loss,allows
R7213 T23477 T23476 cc nor,loss
R7214 T23478 T23476 conj excess,loss
R7215 T23479 T23476 prep of,loss
R7216 T23480 T23481 amod tooth,bud