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PMC:1564426 / 30782-37350 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T17241 0-3 NN denotes K14
T17243 3-4 HYPH denotes -
T17242 4-7 NN denotes cre
T17245 7-8 HYPH denotes –
T17244 8-14 VBN denotes Driven
T17247 15-18 NN denotes Apc
T17246 19-23 NN denotes Loss
T17248 24-31 VBZ denotes Results
T17249 32-34 IN denotes in
T17250 35-46 JJ denotes Hypoplastic
T17252 46-47 HYPH denotes /
T17251 47-54 JJ denotes Athymic
T17253 55-59 NNS denotes Mice
T17254 59-126 sentence denotes Thymus is an organ that is also known to have K14 expression [16].
T17255 60-66 NN denotes Thymus
T17256 67-69 VBZ denotes is
T17257 70-72 DT denotes an
T17258 73-78 NN denotes organ
T17259 79-83 WDT denotes that
T17261 84-86 VBZ denotes is
T17262 87-91 RB denotes also
T17260 92-97 VBN denotes known
T17263 98-100 TO denotes to
T17264 101-105 VB denotes have
T17265 106-109 NN denotes K14
T17266 110-120 NN denotes expression
T17267 121-122 -LRB- denotes [
T17268 122-124 CD denotes 16
T17269 124-125 -RRB- denotes ]
T17270 125-126 . denotes .
T17271 126-208 sentence denotes It represents the primary lymphoid organ for thymocyte development and selection.
T17272 127-129 PRP denotes It
T17273 130-140 VBZ denotes represents
T17274 141-144 DT denotes the
T17276 145-152 JJ denotes primary
T17277 153-161 JJ denotes lymphoid
T17275 162-167 NN denotes organ
T17278 168-171 IN denotes for
T17279 172-181 NN denotes thymocyte
T17280 182-193 NN denotes development
T17281 194-197 CC denotes and
T17282 198-207 NN denotes selection
T17283 207-208 . denotes .
T17284 208-301 sentence denotes Distinct population of TECs of cortex and medulla mediates both of these critical functions.
T17285 209-217 JJ denotes Distinct
T17286 218-228 NN denotes population
T17288 229-231 IN denotes of
T17289 232-236 NNS denotes TECs
T17290 237-239 IN denotes of
T17291 240-246 NN denotes cortex
T17292 247-250 CC denotes and
T17293 251-258 NN denotes medulla
T17287 259-267 VBZ denotes mediates
T17294 268-272 DT denotes both
T17295 273-275 IN denotes of
T17296 276-281 DT denotes these
T17298 282-290 JJ denotes critical
T17297 291-300 NNS denotes functions
T17299 300-301 . denotes .
T17300 301-428 sentence denotes Cortical and medullary TEC subsets are characterized by differential expression of four keratin species: K8, K18, K5, and K14.
T17301 302-310 JJ denotes Cortical
T17303 311-314 CC denotes and
T17304 315-324 JJ denotes medullary
T17305 325-328 NN denotes TEC
T17302 329-336 NNS denotes subsets
T17307 337-340 VBP denotes are
T17306 341-354 VBN denotes characterized
T17308 355-357 IN denotes by
T17309 358-370 JJ denotes differential
T17310 371-381 NN denotes expression
T17311 382-384 IN denotes of
T17312 385-389 CD denotes four
T17314 390-397 NN denotes keratin
T17313 398-405 NNS denotes species
T17315 405-407 : denotes :
T17316 407-409 NN denotes K8
T17317 409-411 , denotes ,
T17318 411-414 NN denotes K18
T17319 414-416 , denotes ,
T17320 416-418 NN denotes K5
T17321 418-420 , denotes ,
T17322 420-423 CC denotes and
T17323 424-427 NN denotes K14
T17324 427-428 . denotes .
T17325 428-589 sentence denotes The normal thymus is a lobulated lymphoid organ, each lobule clearly showing the two distinct TEC compartments, an outer cortex and an inner medulla (Figure 6).
T17326 429-432 DT denotes The
T17328 433-439 JJ denotes normal
T17327 440-446 NN denotes thymus
T17329 447-449 VBZ denotes is
T17330 450-451 DT denotes a
T17332 452-461 VBN denotes lobulated
T17333 462-470 JJ denotes lymphoid
T17331 471-476 NN denotes organ
T17334 476-478 , denotes ,
T17335 478-482 DT denotes each
T17336 483-489 NN denotes lobule
T17338 490-497 RB denotes clearly
T17337 498-505 VBG denotes showing
T17339 506-509 DT denotes the
T17341 510-513 CD denotes two
T17342 514-522 JJ denotes distinct
T17343 523-526 NN denotes TEC
T17340 527-539 NNS denotes compartments
T17344 539-541 , denotes ,
T17345 541-543 DT denotes an
T17347 544-549 JJ denotes outer
T17346 550-556 NN denotes cortex
T17348 557-560 CC denotes and
T17349 561-563 DT denotes an
T17351 564-569 JJ denotes inner
T17350 570-577 NN denotes medulla
T17352 578-579 -LRB- denotes (
T17353 579-585 NN denotes Figure
T17354 586-587 CD denotes 6
T17355 587-588 -RRB- denotes )
T17356 588-589 . denotes .
T17357 589-713 sentence denotes There were no major differences in the histology of thymus between the ages P3 to P17 in phenotypically normal littermates.
T17358 590-595 EX denotes There
T17359 596-600 VBD denotes were
T17360 601-603 DT denotes no
T17362 604-609 JJ denotes major
T17361 610-621 NNS denotes differences
T17363 622-624 IN denotes in
T17364 625-628 DT denotes the
T17365 629-638 NN denotes histology
T17366 639-641 IN denotes of
T17367 642-648 NN denotes thymus
T17368 649-656 IN denotes between
T17369 657-660 DT denotes the
T17370 661-665 NNS denotes ages
T17371 666-668 NN denotes P3
T17372 669-671 IN denotes to
T17373 672-675 NN denotes P17
T17374 676-678 IN denotes in
T17375 679-693 RB denotes phenotypically
T17376 694-700 JJ denotes normal
T17377 701-712 NNS denotes littermates
T17378 712-713 . denotes .
T17379 713-832 sentence denotes As shown in the H&E staining of thymus, the cortex was formed of dense lymphoid tissue that lacks nodules (Figure 6A).
T17380 714-716 IN denotes As
T17381 717-722 VBN denotes shown
T17383 723-725 IN denotes in
T17384 726-729 DT denotes the
T17386 730-731 NN denotes H
T17387 731-732 CC denotes &
T17388 732-733 NN denotes E
T17385 734-742 NN denotes staining
T17389 743-745 IN denotes of
T17390 746-752 NN denotes thymus
T17391 752-754 , denotes ,
T17392 754-757 DT denotes the
T17393 758-764 NN denotes cortex
T17394 765-768 VBD denotes was
T17382 769-775 VBN denotes formed
T17395 776-778 IN denotes of
T17396 779-784 JJ denotes dense
T17398 785-793 JJ denotes lymphoid
T17397 794-800 NN denotes tissue
T17399 801-805 WDT denotes that
T17400 806-811 VBZ denotes lacks
T17401 812-819 NNS denotes nodules
T17402 820-821 -LRB- denotes (
T17404 821-827 NN denotes Figure
T17403 828-830 NN denotes 6A
T17405 830-831 -RRB- denotes )
T17406 831-832 . denotes .
T17407 832-976 sentence denotes Since the stroma of the medulla is less heavily infiltrated with lymphocytes than the cortex, the medulla stained more lightly than the cortex.
T17408 833-838 IN denotes Since
T17410 839-842 DT denotes the
T17411 843-849 NN denotes stroma
T17412 850-852 IN denotes of
T17413 853-856 DT denotes the
T17414 857-864 NN denotes medulla
T17409 865-867 VBZ denotes is
T17416 868-872 RBR denotes less
T17417 873-880 RB denotes heavily
T17418 881-892 JJ denotes infiltrated
T17419 893-897 IN denotes with
T17420 898-909 NNS denotes lymphocytes
T17421 910-914 IN denotes than
T17422 915-918 DT denotes the
T17423 919-925 NN denotes cortex
T17424 925-927 , denotes ,
T17425 927-930 DT denotes the
T17426 931-938 NN denotes medulla
T17415 939-946 VBD denotes stained
T17427 947-951 RBR denotes more
T17428 952-959 RB denotes lightly
T17429 960-964 IN denotes than
T17430 965-968 DT denotes the
T17431 969-975 NN denotes cortex
T17432 975-976 . denotes .
T17433 976-1083 sentence denotes In normal mice, the thymus retains its size until the young adult age and regresses thereafter by atrophy.
T17434 977-979 IN denotes In
T17436 980-986 JJ denotes normal
T17437 987-991 NNS denotes mice
T17438 991-993 , denotes ,
T17439 993-996 DT denotes the
T17440 997-1003 NN denotes thymus
T17435 1004-1011 VBZ denotes retains
T17441 1012-1015 PRP$ denotes its
T17442 1016-1020 NN denotes size
T17443 1021-1026 IN denotes until
T17444 1027-1030 DT denotes the
T17446 1031-1036 JJ denotes young
T17447 1037-1042 JJ denotes adult
T17445 1043-1046 NN denotes age
T17448 1047-1050 CC denotes and
T17449 1051-1060 VBZ denotes regresses
T17450 1061-1071 RB denotes thereafter
T17451 1072-1074 IN denotes by
T17452 1075-1082 NN denotes atrophy
T17453 1082-1083 . denotes .
T17454 1083-1248 sentence denotes In the normal young mice we examined (P3–P17), it is evident that thymocytes were mitotically active in the cortex as determined by BrdU immunostaining (Figure 6B).
T17455 1084-1086 IN denotes In
T17457 1087-1090 DT denotes the
T17459 1091-1097 JJ denotes normal
T17460 1098-1103 JJ denotes young
T17458 1104-1108 NNS denotes mice
T17461 1109-1111 PRP denotes we
T17462 1112-1120 VBD denotes examined
T17463 1121-1122 -LRB- denotes (
T17464 1122-1124 NN denotes P3
T17465 1124-1125 SYM denotes –
T17466 1125-1128 NN denotes P17
T17467 1128-1129 -RRB- denotes )
T17468 1129-1131 , denotes ,
T17469 1131-1133 PRP denotes it
T17456 1134-1136 VBZ denotes is
T17470 1137-1144 JJ denotes evident
T17471 1145-1149 IN denotes that
T17473 1150-1160 NNS denotes thymocytes
T17472 1161-1165 VBD denotes were
T17474 1166-1177 RB denotes mitotically
T17475 1178-1184 JJ denotes active
T17476 1185-1187 IN denotes in
T17477 1188-1191 DT denotes the
T17478 1192-1198 NN denotes cortex
T17479 1199-1201 IN denotes as
T17480 1202-1212 VBN denotes determined
T17481 1213-1215 IN denotes by
T17482 1216-1220 NN denotes BrdU
T17483 1221-1235 NN denotes immunostaining
T17484 1236-1237 -LRB- denotes (
T17486 1237-1243 NN denotes Figure
T17485 1244-1246 NN denotes 6B
T17487 1246-1247 -RRB- denotes )
T17488 1247-1248 . denotes .
T17489 1248-1508 sentence denotes Immunohistochemistry of normal thymus from P3 to P17 mice showed a similar staining pattern for K14 in that its expression was restricted to a small population of TECs in the inner medullary region and in the keratinocytes in Hassall's corpuscles (Figure 6D).
T17490 1249-1269 NN denotes Immunohistochemistry
T17492 1270-1272 IN denotes of
T17493 1273-1279 JJ denotes normal
T17494 1280-1286 NN denotes thymus
T17495 1287-1291 IN denotes from
T17496 1292-1294 NN denotes P3
T17498 1295-1297 IN denotes to
T17499 1298-1301 NN denotes P17
T17497 1302-1306 NNS denotes mice
T17491 1307-1313 VBD denotes showed
T17500 1314-1315 DT denotes a
T17502 1316-1323 JJ denotes similar
T17503 1324-1332 NN denotes staining
T17501 1333-1340 NN denotes pattern
T17504 1341-1344 IN denotes for
T17505 1345-1348 NN denotes K14
T17506 1349-1351 IN denotes in
T17508 1352-1356 IN denotes that
T17509 1357-1360 PRP$ denotes its
T17510 1361-1371 NN denotes expression
T17511 1372-1375 VBD denotes was
T17507 1376-1386 VBN denotes restricted
T17512 1387-1389 IN denotes to
T17513 1390-1391 DT denotes a
T17515 1392-1397 JJ denotes small
T17514 1398-1408 NN denotes population
T17516 1409-1411 IN denotes of
T17517 1412-1416 NNS denotes TECs
T17518 1417-1419 IN denotes in
T17519 1420-1423 DT denotes the
T17521 1424-1429 JJ denotes inner
T17522 1430-1439 JJ denotes medullary
T17520 1440-1446 NN denotes region
T17523 1447-1450 CC denotes and
T17524 1451-1453 IN denotes in
T17525 1454-1457 DT denotes the
T17526 1458-1471 NNS denotes keratinocytes
T17527 1472-1474 IN denotes in
T17528 1475-1482 NNP denotes Hassall
T17530 1482-1484 POS denotes 's
T17529 1485-1495 NNS denotes corpuscles
T17531 1496-1497 -LRB- denotes (
T17533 1497-1503 NN denotes Figure
T17532 1504-1506 NN denotes 6D
T17534 1506-1507 -RRB- denotes )
T17535 1507-1508 . denotes .
T17536 1508-1616 sentence denotes Diffuse cytoplasmic staining for β-catenin was also detected in the medullary epithelial cells (Figure 6C).
T17537 1509-1516 JJ denotes Diffuse
T17539 1517-1528 JJ denotes cytoplasmic
T17538 1529-1537 NN denotes staining
T17541 1538-1541 IN denotes for
T17542 1542-1543 NN denotes β
T17544 1543-1544 HYPH denotes -
T17543 1544-1551 NN denotes catenin
T17545 1552-1555 VBD denotes was
T17546 1556-1560 RB denotes also
T17540 1561-1569 VBN denotes detected
T17547 1570-1572 IN denotes in
T17548 1573-1576 DT denotes the
T17550 1577-1586 JJ denotes medullary
T17551 1587-1597 JJ denotes epithelial
T17549 1598-1603 NNS denotes cells
T17552 1604-1605 -LRB- denotes (
T17554 1605-1611 NN denotes Figure
T17553 1612-1614 NN denotes 6C
T17555 1614-1615 -RRB- denotes )
T17556 1615-1616 . denotes .
T17557 1616-1748 sentence denotes In contrast to K14 expression, diffuse staining for K8 was observed in epithelial cells both in the medulla and cortex (Figure S3).
T17558 1617-1619 IN denotes In
T17560 1620-1628 NN denotes contrast
T17561 1629-1631 IN denotes to
T17562 1632-1635 NN denotes K14
T17563 1636-1646 NN denotes expression
T17564 1646-1648 , denotes ,
T17565 1648-1655 JJ denotes diffuse
T17566 1656-1664 NN denotes staining
T17567 1665-1668 IN denotes for
T17568 1669-1671 NN denotes K8
T17569 1672-1675 VBD denotes was
T17559 1676-1684 VBN denotes observed
T17570 1685-1687 IN denotes in
T17571 1688-1698 JJ denotes epithelial
T17572 1699-1704 NNS denotes cells
T17573 1705-1709 CC denotes both
T17574 1710-1712 IN denotes in
T17575 1713-1716 DT denotes the
T17576 1717-1724 NN denotes medulla
T17577 1725-1728 CC denotes and
T17578 1729-1735 NN denotes cortex
T17579 1736-1737 -LRB- denotes (
T17581 1737-1743 NN denotes Figure
T17580 1744-1746 NN denotes S3
T17582 1746-1747 -RRB- denotes )
T17583 1747-1748 . denotes .
T17584 1748-1908 sentence denotes K1 staining was not detected in young mice at P3 but in older mice it was detected in differentiated keratinocytes in some of Hassall's corpuscles (Figure S3).
T17585 1749-1751 NN denotes K1
T17586 1752-1760 NN denotes staining
T17588 1761-1764 VBD denotes was
T17589 1765-1768 RB denotes not
T17587 1769-1777 VBN denotes detected
T17590 1778-1780 IN denotes in
T17591 1781-1786 JJ denotes young
T17592 1787-1791 NNS denotes mice
T17593 1792-1794 IN denotes at
T17594 1795-1797 NN denotes P3
T17595 1798-1801 CC denotes but
T17596 1802-1804 IN denotes in
T17598 1805-1810 JJR denotes older
T17599 1811-1815 NNS denotes mice
T17600 1816-1818 PRP denotes it
T17601 1819-1822 VBD denotes was
T17597 1823-1831 VBN denotes detected
T17602 1832-1834 IN denotes in
T17603 1835-1849 VBN denotes differentiated
T17604 1850-1863 NNS denotes keratinocytes
T17605 1864-1866 IN denotes in
T17606 1867-1871 DT denotes some
T17607 1872-1874 IN denotes of
T17608 1875-1882 NNP denotes Hassall
T17610 1882-1884 POS denotes 's
T17609 1885-1895 NNS denotes corpuscles
T17611 1896-1897 -LRB- denotes (
T17613 1897-1903 NN denotes Figure
T17612 1904-1906 NN denotes S3
T17614 1906-1907 -RRB- denotes )
T17615 1907-1908 . denotes .
T17616 1908-2527 sentence denotes Figure 6 Histological and Immunochemical Examination of Thymus (A–D) P3 normal thymus. (E–G) Mild P3 mutant thymus. (H–K) Severe P3 mutant thymus. (L–O) P13 mutant thymus. Stained with H&E for histology (A, E, H, L), BrdU (B, I, M), β-catenin (C, F, J, N), and K14 (D, G, K, O). (B) Actively dividing thymocytes are visible at the superficial edge of cortex of normal P3 thymus. Note the progression of histological abnormalities in the mutant thymus from mild P3, severe P3 to P13 (A, E, H, L). Scale bars, 20 μm. The histological abnormalities of thymus were evident as early as P3 in KA mutants (Figure 6E and 6H).
T17617 2425-2428 DT denotes The
T17619 2429-2441 JJ denotes histological
T17618 2442-2455 NNS denotes abnormalities
T17621 2456-2458 IN denotes of
T17622 2459-2465 NN denotes thymus
T17620 2466-2470 VBD denotes were
T17623 2471-2478 JJ denotes evident
T17624 2479-2481 RB denotes as
T17625 2482-2487 RB denotes early
T17626 2488-2490 IN denotes as
T17627 2491-2493 NN denotes P3
T17628 2494-2496 IN denotes in
T17629 2497-2499 NN denotes KA
T17630 2500-2507 NNS denotes mutants
T17631 2508-2509 -LRB- denotes (
T17633 2509-2515 NN denotes Figure
T17632 2516-2518 NN denotes 6E
T17634 2519-2522 CC denotes and
T17635 2523-2525 NN denotes 6H
T17636 2525-2526 -RRB- denotes )
T17637 2526-2527 . denotes .
T17638 2527-2691 sentence denotes The thymus was made of two lobules as in the normal mice but the mutant thymus was significantly smaller in size than that of the age-matched controls (Figure 2G).
T17639 2528-2531 DT denotes The
T17640 2532-2538 NN denotes thymus
T17642 2539-2542 VBD denotes was
T17641 2543-2547 VBN denotes made
T17643 2548-2550 IN denotes of
T17644 2551-2554 CD denotes two
T17645 2555-2562 NNS denotes lobules
T17646 2563-2565 IN denotes as
T17647 2566-2568 IN denotes in
T17648 2569-2572 DT denotes the
T17650 2573-2579 JJ denotes normal
T17649 2580-2584 NNS denotes mice
T17651 2585-2588 CC denotes but
T17652 2589-2592 DT denotes the
T17654 2593-2599 JJ denotes mutant
T17653 2600-2606 NN denotes thymus
T17655 2607-2610 VBD denotes was
T17656 2611-2624 RB denotes significantly
T17657 2625-2632 JJR denotes smaller
T17658 2633-2635 IN denotes in
T17659 2636-2640 NN denotes size
T17660 2641-2645 IN denotes than
T17661 2646-2650 DT denotes that
T17662 2651-2653 IN denotes of
T17663 2654-2657 DT denotes the
T17665 2658-2661 NN denotes age
T17667 2661-2662 HYPH denotes -
T17666 2662-2669 JJ denotes matched
T17664 2670-2678 NNS denotes controls
T17668 2679-2680 -LRB- denotes (
T17670 2680-2686 NN denotes Figure
T17669 2687-2689 NN denotes 2G
T17671 2689-2690 -RRB- denotes )
T17672 2690-2691 . denotes .
T17673 2691-2851 sentence denotes Interestingly, variations in the phenotypic severity of the mutant pups at P3 were prominently reflected in the extent of histological abnormalities of thymus.
T17674 2692-2705 RB denotes Interestingly
T17676 2705-2707 , denotes ,
T17677 2707-2717 NNS denotes variations
T17678 2718-2720 IN denotes in
T17679 2721-2724 DT denotes the
T17681 2725-2735 JJ denotes phenotypic
T17680 2736-2744 NN denotes severity
T17682 2745-2747 IN denotes of
T17683 2748-2751 DT denotes the
T17685 2752-2758 JJ denotes mutant
T17684 2759-2763 NNS denotes pups
T17686 2764-2766 IN denotes at
T17687 2767-2769 NN denotes P3
T17688 2770-2774 VBD denotes were
T17689 2775-2786 RB denotes prominently
T17675 2787-2796 VBN denotes reflected
T17690 2797-2799 IN denotes in
T17691 2800-2803 DT denotes the
T17692 2804-2810 NN denotes extent
T17693 2811-2813 IN denotes of
T17694 2814-2826 JJ denotes histological
T17695 2827-2840 NNS denotes abnormalities
T17696 2841-2843 IN denotes of
T17697 2844-2850 NN denotes thymus
T17698 2850-2851 . denotes .
T17699 2851-3092 sentence denotes A P3 KA mutant pup that showed milder phenotype with a comparable body weight to its normal littermates (Figure 2A, M2) showed milder thymus abnormalities (Figure 6E) compared to its more severe mutant littermate (Figure 2A, M1; Figure 6H).
T17700 2852-2853 DT denotes A
T17702 2854-2856 NN denotes P3
T17703 2857-2859 NN denotes KA
T17704 2860-2866 JJ denotes mutant
T17701 2867-2870 NN denotes pup
T17706 2871-2875 WDT denotes that
T17707 2876-2882 VBD denotes showed
T17708 2883-2889 JJR denotes milder
T17709 2890-2899 NN denotes phenotype
T17710 2900-2904 IN denotes with
T17711 2905-2906 DT denotes a
T17713 2907-2917 JJ denotes comparable
T17714 2918-2922 NN denotes body
T17712 2923-2929 NN denotes weight
T17715 2930-2932 IN denotes to
T17716 2933-2936 PRP$ denotes its
T17718 2937-2943 JJ denotes normal
T17717 2944-2955 NNS denotes littermates
T17719 2956-2957 -LRB- denotes (
T17721 2957-2963 NN denotes Figure
T17720 2964-2966 NN denotes 2A
T17722 2966-2968 , denotes ,
T17723 2968-2970 NN denotes M2
T17724 2970-2971 -RRB- denotes )
T17705 2972-2978 VBD denotes showed
T17725 2979-2985 JJR denotes milder
T17727 2986-2992 NN denotes thymus
T17726 2993-3006 NNS denotes abnormalities
T17728 3007-3008 -LRB- denotes (
T17730 3008-3014 NN denotes Figure
T17729 3015-3017 NN denotes 6E
T17731 3017-3018 -RRB- denotes )
T17732 3019-3027 VBN denotes compared
T17733 3028-3030 IN denotes to
T17734 3031-3034 PRP$ denotes its
T17736 3035-3039 RBR denotes more
T17737 3040-3046 JJ denotes severe
T17738 3047-3053 JJ denotes mutant
T17735 3054-3064 NN denotes littermate
T17739 3065-3066 -LRB- denotes (
T17741 3066-3072 NN denotes Figure
T17740 3073-3075 NN denotes 2A
T17742 3075-3077 , denotes ,
T17743 3077-3079 NN denotes M1
T17744 3079-3080 : denotes ;
T17745 3081-3087 NN denotes Figure
T17746 3088-3090 NN denotes 6H
T17747 3090-3091 -RRB- denotes )
T17748 3091-3092 . denotes .
T17749 3092-3350 sentence denotes The milder P3 mutant thymus was already much smaller in size compared to those of normal littermates (data not shown) but two epithelial compartments of thymus were histologically still distinguishable, with colonization of thymocytes evident in the cortex.
T17750 3093-3096 DT denotes The
T17752 3097-3103 JJR denotes milder
T17753 3104-3106 NN denotes P3
T17754 3107-3113 JJ denotes mutant
T17751 3114-3120 NN denotes thymus
T17755 3121-3124 VBD denotes was
T17756 3125-3132 RB denotes already
T17757 3133-3137 RB denotes much
T17758 3138-3145 JJR denotes smaller
T17759 3146-3148 IN denotes in
T17760 3149-3153 NN denotes size
T17761 3154-3162 VBN denotes compared
T17762 3163-3165 IN denotes to
T17763 3166-3171 DT denotes those
T17764 3172-3174 IN denotes of
T17765 3175-3181 JJ denotes normal
T17766 3182-3193 NNS denotes littermates
T17767 3194-3195 -LRB- denotes (
T17769 3195-3199 NNS denotes data
T17770 3200-3203 RB denotes not
T17768 3204-3209 VBN denotes shown
T17771 3209-3210 -RRB- denotes )
T17772 3211-3214 CC denotes but
T17773 3215-3218 CD denotes two
T17775 3219-3229 JJ denotes epithelial
T17774 3230-3242 NNS denotes compartments
T17777 3243-3245 IN denotes of
T17778 3246-3252 NN denotes thymus
T17776 3253-3257 VBD denotes were
T17779 3258-3272 RB denotes histologically
T17780 3273-3278 RB denotes still
T17781 3279-3294 JJ denotes distinguishable
T17782 3294-3296 , denotes ,
T17783 3296-3300 IN denotes with
T17785 3301-3313 NN denotes colonization
T17786 3314-3316 IN denotes of
T17787 3317-3327 NNS denotes thymocytes
T17784 3328-3335 JJ denotes evident
T17788 3336-3338 IN denotes in
T17789 3339-3342 DT denotes the
T17790 3343-3349 NN denotes cortex
T17791 3349-3350 . denotes .
T17792 3350-3683 sentence denotes However, there were small populations of lightly stained cells by H&E extending from the edge of the outer cortex towards inner medulla (Figure 6E), and these cells showed intense nuclear β-catenin staining whereas the rest of the medullary cells showed diffuse β-catenin staining pattern similar to that of the control (Figure 6F).
T17793 3351-3358 RB denotes However
T17795 3358-3360 , denotes ,
T17796 3360-3365 EX denotes there
T17794 3366-3370 VBD denotes were
T17797 3371-3376 JJ denotes small
T17798 3377-3388 NNS denotes populations
T17799 3389-3391 IN denotes of
T17800 3392-3399 RB denotes lightly
T17801 3400-3407 VBN denotes stained
T17802 3408-3413 NNS denotes cells
T17803 3414-3416 IN denotes by
T17804 3417-3418 NN denotes H
T17805 3418-3419 CC denotes &
T17806 3419-3420 NN denotes E
T17807 3421-3430 VBG denotes extending
T17808 3431-3435 IN denotes from
T17809 3436-3439 DT denotes the
T17810 3440-3444 NN denotes edge
T17811 3445-3447 IN denotes of
T17812 3448-3451 DT denotes the
T17814 3452-3457 JJ denotes outer
T17813 3458-3464 NN denotes cortex
T17815 3465-3472 IN denotes towards
T17816 3473-3478 JJ denotes inner
T17817 3479-3486 NN denotes medulla
T17818 3487-3488 -LRB- denotes (
T17820 3488-3494 NN denotes Figure
T17819 3495-3497 NN denotes 6E
T17821 3497-3498 -RRB- denotes )
T17822 3498-3500 , denotes ,
T17823 3500-3503 CC denotes and
T17824 3504-3509 DT denotes these
T17825 3510-3515 NNS denotes cells
T17826 3516-3522 VBD denotes showed
T17827 3523-3530 JJ denotes intense
T17829 3531-3538 JJ denotes nuclear
T17830 3539-3540 NN denotes β
T17832 3540-3541 HYPH denotes -
T17831 3541-3548 NN denotes catenin
T17828 3549-3557 NN denotes staining
T17833 3558-3565 IN denotes whereas
T17835 3566-3569 DT denotes the
T17836 3570-3574 NN denotes rest
T17837 3575-3577 IN denotes of
T17838 3578-3581 DT denotes the
T17840 3582-3591 JJ denotes medullary
T17839 3592-3597 NNS denotes cells
T17834 3598-3604 VBD denotes showed
T17841 3605-3612 JJ denotes diffuse
T17843 3613-3614 NN denotes β
T17845 3614-3615 HYPH denotes -
T17844 3615-3622 NN denotes catenin
T17846 3623-3631 NN denotes staining
T17842 3632-3639 NN denotes pattern
T17847 3640-3647 JJ denotes similar
T17848 3648-3650 IN denotes to
T17849 3651-3655 DT denotes that
T17850 3656-3658 IN denotes of
T17851 3659-3662 DT denotes the
T17852 3663-3670 NN denotes control
T17853 3671-3672 -LRB- denotes (
T17855 3672-3678 NN denotes Figure
T17854 3679-3681 NN denotes 6F
T17856 3681-3682 -RRB- denotes )
T17857 3682-3683 . denotes .
T17858 3683-3799 sentence denotes Localization of K14 was limited to a few cells in the medulla and some overlapped with K8 localization (Figure 6G).
T17859 3684-3696 NN denotes Localization
T17861 3697-3699 IN denotes of
T17862 3700-3703 NN denotes K14
T17863 3704-3707 VBD denotes was
T17860 3708-3715 VBN denotes limited
T17864 3716-3718 IN denotes to
T17865 3719-3720 DT denotes a
T17867 3721-3724 JJ denotes few
T17866 3725-3730 NNS denotes cells
T17868 3731-3733 IN denotes in
T17869 3734-3737 DT denotes the
T17870 3738-3745 NN denotes medulla
T17871 3746-3749 CC denotes and
T17872 3750-3754 DT denotes some
T17873 3755-3765 VBN denotes overlapped
T17874 3766-3770 IN denotes with
T17875 3771-3773 NN denotes K8
T17876 3774-3786 NN denotes localization
T17877 3787-3788 -LRB- denotes (
T17879 3788-3794 NN denotes Figure
T17878 3795-3797 NN denotes 6G
T17880 3797-3798 -RRB- denotes )
T17881 3798-3799 . denotes .
T17882 3799-3991 sentence denotes In the other P3 mutant thymus the distinct thymic epithelial compartments have been lost completely, and only a few lymphocytes were remaining at the edges and some in the middle (Figure 6H).
T17883 3800-3802 IN denotes In
T17885 3803-3806 DT denotes the
T17887 3807-3812 JJ denotes other
T17888 3813-3815 NN denotes P3
T17889 3816-3822 JJ denotes mutant
T17886 3823-3829 NN denotes thymus
T17890 3830-3833 DT denotes the
T17892 3834-3842 JJ denotes distinct
T17893 3843-3849 JJ denotes thymic
T17894 3850-3860 JJ denotes epithelial
T17891 3861-3873 NNS denotes compartments
T17895 3874-3878 VBP denotes have
T17896 3879-3883 VBN denotes been
T17884 3884-3888 VBN denotes lost
T17897 3889-3899 RB denotes completely
T17898 3899-3901 , denotes ,
T17899 3901-3904 CC denotes and
T17900 3905-3909 RB denotes only
T17902 3910-3911 DT denotes a
T17903 3912-3915 JJ denotes few
T17901 3916-3927 NNS denotes lymphocytes
T17905 3928-3932 VBD denotes were
T17904 3933-3942 VBG denotes remaining
T17906 3943-3945 IN denotes at
T17907 3946-3949 DT denotes the
T17908 3950-3955 NNS denotes edges
T17909 3956-3959 CC denotes and
T17910 3960-3964 DT denotes some
T17911 3965-3967 IN denotes in
T17912 3968-3971 DT denotes the
T17913 3972-3978 JJ denotes middle
T17914 3979-3980 -LRB- denotes (
T17916 3980-3986 NN denotes Figure
T17915 3987-3989 NN denotes 6H
T17917 3989-3990 -RRB- denotes )
T17918 3990-3991 . denotes .
T17919 3991-4175 sentence denotes Proliferative activities were no longer observed in thymocytes as prominently as in the normal thymus, but the epithelial cells seemed to be forming concentric structures (Figure 6I).
T17920 3992-4005 JJ denotes Proliferative
T17921 4006-4016 NNS denotes activities
T17923 4017-4021 VBD denotes were
T17924 4022-4024 RB denotes no
T17925 4025-4031 RBR denotes longer
T17922 4032-4040 VBN denotes observed
T17926 4041-4043 IN denotes in
T17927 4044-4054 NNS denotes thymocytes
T17928 4055-4057 RB denotes as
T17929 4058-4069 RB denotes prominently
T17930 4070-4072 IN denotes as
T17931 4073-4075 IN denotes in
T17932 4076-4079 DT denotes the
T17934 4080-4086 JJ denotes normal
T17933 4087-4093 NN denotes thymus
T17935 4093-4095 , denotes ,
T17936 4095-4098 CC denotes but
T17937 4099-4102 DT denotes the
T17939 4103-4113 JJ denotes epithelial
T17938 4114-4119 NNS denotes cells
T17940 4120-4126 VBD denotes seemed
T17941 4127-4129 TO denotes to
T17943 4130-4132 VB denotes be
T17942 4133-4140 VBG denotes forming
T17944 4141-4151 JJ denotes concentric
T17945 4152-4162 NNS denotes structures
T17946 4163-4164 -LRB- denotes (
T17948 4164-4170 NN denotes Figure
T17947 4171-4173 NN denotes 6I
T17949 4173-4174 -RRB- denotes )
T17950 4174-4175 . denotes .
T17951 4175-4326 sentence denotes Unlike in the normal or mild mutant thymi, the severe P3 mutant thymus showed extensive K14 expression that overlapped with K8 expression (Figure 6K).
T17952 4176-4182 IN denotes Unlike
T17954 4183-4185 IN denotes in
T17955 4186-4189 DT denotes the
T17957 4190-4196 JJ denotes normal
T17958 4197-4199 CC denotes or
T17959 4200-4204 JJ denotes mild
T17960 4205-4211 JJ denotes mutant
T17956 4212-4217 NNS denotes thymi
T17961 4217-4219 , denotes ,
T17962 4219-4222 DT denotes the
T17964 4223-4229 JJ denotes severe
T17965 4230-4232 NN denotes P3
T17966 4233-4239 JJ denotes mutant
T17963 4240-4246 NN denotes thymus
T17953 4247-4253 VBD denotes showed
T17967 4254-4263 JJ denotes extensive
T17969 4264-4267 NN denotes K14
T17968 4268-4278 NN denotes expression
T17970 4279-4283 WDT denotes that
T17971 4284-4294 VBD denotes overlapped
T17972 4295-4299 IN denotes with
T17973 4300-4302 NN denotes K8
T17974 4303-4313 NN denotes expression
T17975 4314-4315 -LRB- denotes (
T17977 4315-4321 NN denotes Figure
T17976 4322-4324 NN denotes 6K
T17978 4324-4325 -RRB- denotes )
T17979 4325-4326 . denotes .
T17980 4326-4521 sentence denotes These cells were more like basal cells of the skin than TECs and were adjacent to the most immature looking cells that were showing strong nuclear and cytoplasmic β-catenin staining (Figure 6J).
T17981 4327-4332 DT denotes These
T17982 4333-4338 NNS denotes cells
T17983 4339-4343 VBD denotes were
T17984 4344-4348 RBR denotes more
T17985 4349-4353 IN denotes like
T17986 4354-4359 JJ denotes basal
T17987 4360-4365 NNS denotes cells
T17988 4366-4368 IN denotes of
T17989 4369-4372 DT denotes the
T17990 4373-4377 NN denotes skin
T17991 4378-4382 IN denotes than
T17992 4383-4387 NNS denotes TECs
T17993 4388-4391 CC denotes and
T17994 4392-4396 VBD denotes were
T17995 4397-4405 JJ denotes adjacent
T17996 4406-4408 IN denotes to
T17997 4409-4412 DT denotes the
T17999 4413-4417 RBS denotes most
T18000 4418-4426 JJ denotes immature
T18001 4427-4434 VBG denotes looking
T17998 4435-4440 NNS denotes cells
T18002 4441-4445 WDT denotes that
T18004 4446-4450 VBD denotes were
T18003 4451-4458 VBG denotes showing
T18005 4459-4465 JJ denotes strong
T18007 4466-4473 JJ denotes nuclear
T18008 4474-4477 CC denotes and
T18009 4478-4489 JJ denotes cytoplasmic
T18010 4490-4491 NN denotes β
T18012 4491-4492 HYPH denotes -
T18011 4492-4499 NN denotes catenin
T18006 4500-4508 NN denotes staining
T18013 4509-4510 -LRB- denotes (
T18015 4510-4516 NN denotes Figure
T18014 4517-4519 NN denotes 6J
T18016 4519-4520 -RRB- denotes )
T18017 4520-4521 . denotes .
T18018 4521-4618 sentence denotes The nuclear staining of β-catenin was not observed in the normal age-matched thymus (Figure 6C).
T18019 4522-4525 DT denotes The
T18021 4526-4533 JJ denotes nuclear
T18020 4534-4542 NN denotes staining
T18023 4543-4545 IN denotes of
T18024 4546-4547 NN denotes β
T18026 4547-4548 HYPH denotes -
T18025 4548-4555 NN denotes catenin
T18027 4556-4559 VBD denotes was
T18028 4560-4563 RB denotes not
T18022 4564-4572 VBN denotes observed
T18029 4573-4575 IN denotes in
T18030 4576-4579 DT denotes the
T18032 4580-4586 JJ denotes normal
T18033 4587-4590 NN denotes age
T18035 4590-4591 HYPH denotes -
T18034 4591-4598 JJ denotes matched
T18031 4599-4605 NN denotes thymus
T18036 4606-4607 -LRB- denotes (
T18038 4607-4613 NN denotes Figure
T18037 4614-4616 NN denotes 6C
T18039 4616-4617 -RRB- denotes )
T18040 4617-4618 . denotes .
T18041 4618-4716 sentence denotes Most notably, the K14 and β-catenin staining patterns were mutually exclusive (Figure 6J and 6K).
T18042 4619-4623 RBS denotes Most
T18043 4624-4631 RB denotes notably
T18045 4631-4633 , denotes ,
T18046 4633-4636 DT denotes the
T18048 4637-4640 NN denotes K14
T18049 4641-4644 CC denotes and
T18050 4645-4646 NN denotes β
T18052 4646-4647 HYPH denotes -
T18051 4647-4654 NN denotes catenin
T18053 4655-4663 NN denotes staining
T18047 4664-4672 NNS denotes patterns
T18044 4673-4677 VBD denotes were
T18054 4678-4686 RB denotes mutually
T18055 4687-4696 JJ denotes exclusive
T18056 4697-4698 -LRB- denotes (
T18058 4698-4704 NN denotes Figure
T18057 4705-4707 NN denotes 6J
T18059 4708-4711 CC denotes and
T18060 4712-4714 NN denotes 6K
T18061 4714-4715 -RRB- denotes )
T18062 4715-4716 . denotes .
T18063 4716-4940 sentence denotes At P10–P13, the mutant thymus consisted of numerous enlarged Hassall's corpuscle–like structures, made of arrays of K14- and K8-expressing keratinizing epithelial cells surrounding large keratin deposits (Figure 6L and 6O).
T18064 4717-4719 IN denotes At
T18066 4720-4723 NN denotes P10
T18067 4723-4724 SYM denotes –
T18068 4724-4727 NN denotes P13
T18069 4727-4729 , denotes ,
T18070 4729-4732 DT denotes the
T18072 4733-4739 JJ denotes mutant
T18071 4740-4746 NN denotes thymus
T18065 4747-4756 VBD denotes consisted
T18073 4757-4759 IN denotes of
T18074 4760-4768 JJ denotes numerous
T18076 4769-4777 VBN denotes enlarged
T18077 4778-4785 NNP denotes Hassall
T18078 4785-4787 POS denotes 's
T18079 4788-4797 NN denotes corpuscle
T18081 4797-4798 HYPH denotes –
T18080 4798-4802 JJ denotes like
T18075 4803-4813 NNS denotes structures
T18082 4813-4815 , denotes ,
T18083 4815-4819 VBN denotes made
T18084 4820-4822 IN denotes of
T18085 4823-4829 NNS denotes arrays
T18086 4830-4832 IN denotes of
T18087 4833-4836 NN denotes K14
T18089 4836-4837 HYPH denotes -
T18090 4838-4841 CC denotes and
T18091 4842-4844 NN denotes K8
T18092 4844-4845 HYPH denotes -
T18088 4845-4855 VBG denotes expressing
T18094 4856-4868 VBG denotes keratinizing
T18095 4869-4879 JJ denotes epithelial
T18093 4880-4885 NNS denotes cells
T18096 4886-4897 VBG denotes surrounding
T18097 4898-4903 JJ denotes large
T18099 4904-4911 NN denotes keratin
T18098 4912-4920 NNS denotes deposits
T18100 4921-4922 -LRB- denotes (
T18102 4922-4928 NN denotes Figure
T18101 4929-4931 NN denotes 6L
T18103 4932-4935 CC denotes and
T18104 4936-4938 NN denotes 6O
T18105 4938-4939 -RRB- denotes )
T18106 4939-4940 . denotes .
T18107 4940-5097 sentence denotes There were numerous neutrophils and macrophages infiltrating the thymus in response to these keratins; hence, these structures could be called pyogranuloma.
T18108 4941-4946 EX denotes There
T18109 4947-4951 VBD denotes were
T18111 4952-4960 JJ denotes numerous
T18112 4961-4972 NNS denotes neutrophils
T18113 4973-4976 CC denotes and
T18114 4977-4988 NNS denotes macrophages
T18115 4989-5001 VBG denotes infiltrating
T18116 5002-5005 DT denotes the
T18117 5006-5012 NN denotes thymus
T18118 5013-5015 IN denotes in
T18119 5016-5024 NN denotes response
T18120 5025-5027 IN denotes to
T18121 5028-5033 DT denotes these
T18122 5034-5042 NNS denotes keratins
T18123 5042-5043 : denotes ;
T18124 5044-5049 RB denotes hence
T18125 5049-5051 , denotes ,
T18126 5051-5056 DT denotes these
T18127 5057-5067 NNS denotes structures
T18128 5068-5073 MD denotes could
T18129 5074-5076 VB denotes be
T18110 5077-5083 VBN denotes called
T18130 5084-5096 NN denotes pyogranuloma
T18131 5096-5097 . denotes .
T18132 5097-5314 sentence denotes Varying degrees of differentiation-specific markers depending on the age of mice, in this case K1 and involucrin that are normally present only in Hassall's corpuscles, were also detected in mutant thymi (Figure S3).
T18133 5098-5105 VBG denotes Varying
T18134 5106-5113 NNS denotes degrees
T18136 5114-5116 IN denotes of
T18137 5117-5132 NN denotes differentiation
T18139 5132-5133 HYPH denotes -
T18138 5133-5141 JJ denotes specific
T18140 5142-5149 NNS denotes markers
T18141 5150-5159 VBG denotes depending
T18142 5160-5162 IN denotes on
T18143 5163-5166 DT denotes the
T18144 5167-5170 NN denotes age
T18145 5171-5173 IN denotes of
T18146 5174-5178 NNS denotes mice
T18147 5178-5180 , denotes ,
T18148 5180-5182 IN denotes in
T18150 5183-5187 DT denotes this
T18151 5188-5192 NN denotes case
T18149 5193-5195 NN denotes K1
T18152 5196-5199 CC denotes and
T18153 5200-5210 NN denotes involucrin
T18154 5211-5215 WDT denotes that
T18155 5216-5219 VBP denotes are
T18156 5220-5228 RB denotes normally
T18157 5229-5236 JJ denotes present
T18158 5237-5241 RB denotes only
T18159 5242-5244 IN denotes in
T18160 5245-5252 NNP denotes Hassall
T18162 5252-5254 POS denotes 's
T18161 5255-5265 NNS denotes corpuscles
T18163 5265-5267 , denotes ,
T18164 5267-5271 VBD denotes were
T18165 5272-5276 RB denotes also
T18135 5277-5285 VBN denotes detected
T18166 5286-5288 IN denotes in
T18167 5289-5295 JJ denotes mutant
T18168 5296-5301 NNS denotes thymi
T18169 5302-5303 -LRB- denotes (
T18171 5303-5309 NN denotes Figure
T18170 5310-5312 NN denotes S3
T18172 5312-5313 -RRB- denotes )
T18173 5313-5314 . denotes .
T18174 5314-5359 sentence denotes In these mice no thymocytes were detectable.
T18175 5315-5317 IN denotes In
T18177 5318-5323 DT denotes these
T18178 5324-5328 NNS denotes mice
T18179 5329-5331 DT denotes no
T18180 5332-5342 NNS denotes thymocytes
T18176 5343-5347 VBD denotes were
T18181 5348-5358 JJ denotes detectable
T18182 5358-5359 . denotes .
T18183 5359-5507 sentence denotes BrdU incorporation was only observed in very few keratinizing epithelial cells, looking somewhat similar to the pattern of mature skin (Figure 6M).
T18184 5360-5364 NN denotes BrdU
T18185 5365-5378 NN denotes incorporation
T18187 5379-5382 VBD denotes was
T18188 5383-5387 RB denotes only
T18189 5388-5396 VBN denotes observed
T18190 5397-5399 IN denotes in
T18191 5400-5404 RB denotes very
T18192 5405-5408 JJ denotes few
T18194 5409-5421 VBG denotes keratinizing
T18195 5422-5432 JJ denotes epithelial
T18193 5433-5438 NNS denotes cells
T18196 5438-5440 , denotes ,
T18186 5440-5447 VBG denotes looking
T18197 5448-5456 RB denotes somewhat
T18198 5457-5464 JJ denotes similar
T18199 5465-5467 IN denotes to
T18200 5468-5471 DT denotes the
T18201 5472-5479 NN denotes pattern
T18202 5480-5482 IN denotes of
T18203 5483-5489 JJ denotes mature
T18204 5490-5494 NN denotes skin
T18205 5495-5496 -LRB- denotes (
T18207 5496-5502 NN denotes Figure
T18206 5503-5505 NN denotes 6M
T18208 5505-5506 -RRB- denotes )
T18209 5506-5507 . denotes .
T18210 5507-5673 sentence denotes The diffuse expression of β-catenin was also present in these epithelial cells, and at this age fewer cells were positive for nuclear β-catenin staining (Figure 6N).
T18211 5508-5511 DT denotes The
T18213 5512-5519 JJ denotes diffuse
T18212 5520-5530 NN denotes expression
T18215 5531-5533 IN denotes of
T18216 5534-5535 NN denotes β
T18218 5535-5536 HYPH denotes -
T18217 5536-5543 NN denotes catenin
T18214 5544-5547 VBD denotes was
T18219 5548-5552 RB denotes also
T18220 5553-5560 JJ denotes present
T18221 5561-5563 IN denotes in
T18222 5564-5569 DT denotes these
T18224 5570-5580 JJ denotes epithelial
T18223 5581-5586 NNS denotes cells
T18225 5586-5588 , denotes ,
T18226 5588-5591 CC denotes and
T18227 5592-5594 IN denotes at
T18229 5595-5599 DT denotes this
T18230 5600-5603 NN denotes age
T18231 5604-5609 JJR denotes fewer
T18232 5610-5615 NNS denotes cells
T18228 5616-5620 VBD denotes were
T18233 5621-5629 JJ denotes positive
T18234 5630-5633 IN denotes for
T18235 5634-5641 JJ denotes nuclear
T18237 5642-5643 NN denotes β
T18239 5643-5644 HYPH denotes -
T18238 5644-5651 NN denotes catenin
T18236 5652-5660 NN denotes staining
T18240 5661-5662 -LRB- denotes (
T18242 5662-5668 NN denotes Figure
T18241 5669-5671 NN denotes 6N
T18243 5671-5672 -RRB- denotes )
T18244 5672-5673 . denotes .
T18245 5673-5834 sentence denotes As in the younger mutant mice, however, nuclear localization of β-catenin was only observed in K14-negative cells that looked like undifferentiated basal cells.
T18246 5674-5676 IN denotes As
T18248 5677-5679 IN denotes in
T18249 5680-5683 DT denotes the
T18251 5684-5691 JJR denotes younger
T18252 5692-5698 JJ denotes mutant
T18250 5699-5703 NNS denotes mice
T18253 5703-5705 , denotes ,
T18254 5705-5712 RB denotes however
T18255 5712-5714 , denotes ,
T18256 5714-5721 JJ denotes nuclear
T18257 5722-5734 NN denotes localization
T18258 5735-5737 IN denotes of
T18259 5738-5739 NN denotes β
T18261 5739-5740 HYPH denotes -
T18260 5740-5747 NN denotes catenin
T18262 5748-5751 VBD denotes was
T18263 5752-5756 RB denotes only
T18247 5757-5765 VBN denotes observed
T18264 5766-5768 IN denotes in
T18265 5769-5772 NN denotes K14
T18267 5772-5773 HYPH denotes -
T18266 5773-5781 JJ denotes negative
T18268 5782-5787 NNS denotes cells
T18269 5788-5792 WDT denotes that
T18270 5793-5799 VBD denotes looked
T18271 5800-5804 IN denotes like
T18272 5805-5821 JJ denotes undifferentiated
T18274 5822-5827 JJ denotes basal
T18273 5828-5833 NNS denotes cells
T18275 5833-5834 . denotes .
T18276 5834-6093 sentence denotes In older P17 mice, the histopathology and keratin expression pattern of the mutant thymus was similar to that of P13 except for the fact that β-catenin expression became increasingly diffuse and appeared to colocalize with K8/K14 expression (data not shown).
T18277 5835-5837 IN denotes In
T18279 5838-5843 JJR denotes older
T18281 5844-5847 NN denotes P17
T18280 5848-5852 NNS denotes mice
T18282 5852-5854 , denotes ,
T18283 5854-5857 DT denotes the
T18284 5858-5872 NN denotes histopathology
T18285 5873-5876 CC denotes and
T18286 5877-5884 NN denotes keratin
T18288 5885-5895 NN denotes expression
T18287 5896-5903 NN denotes pattern
T18289 5904-5906 IN denotes of
T18290 5907-5910 DT denotes the
T18292 5911-5917 JJ denotes mutant
T18291 5918-5924 NN denotes thymus
T18278 5925-5928 VBD denotes was
T18293 5929-5936 JJ denotes similar
T18294 5937-5939 IN denotes to
T18295 5940-5944 DT denotes that
T18296 5945-5947 IN denotes of
T18297 5948-5951 NN denotes P13
T18298 5952-5958 IN denotes except
T18299 5959-5962 IN denotes for
T18300 5963-5966 DT denotes the
T18301 5967-5971 NN denotes fact
T18302 5972-5976 IN denotes that
T18304 5977-5978 NN denotes β
T18306 5978-5979 HYPH denotes -
T18305 5979-5986 NN denotes catenin
T18307 5987-5997 NN denotes expression
T18303 5998-6004 VBD denotes became
T18308 6005-6017 RB denotes increasingly
T18309 6018-6025 JJ denotes diffuse
T18310 6026-6029 CC denotes and
T18311 6030-6038 VBD denotes appeared
T18312 6039-6041 TO denotes to
T18313 6042-6052 VB denotes colocalize
T18314 6053-6057 IN denotes with
T18315 6058-6060 NN denotes K8
T18317 6060-6061 HYPH denotes /
T18316 6061-6064 NN denotes K14
T18318 6065-6075 NN denotes expression
T18319 6076-6077 -LRB- denotes (
T18321 6077-6081 NNS denotes data
T18322 6082-6085 RB denotes not
T18320 6086-6091 VBN denotes shown
T18323 6091-6092 -RRB- denotes )
T18324 6092-6093 . denotes .
T18325 6093-6162 sentence denotes This coincided with fewer immature cells in the older mutant thymus.
T18326 6094-6098 DT denotes This
T18327 6099-6108 VBD denotes coincided
T18328 6109-6113 IN denotes with
T18329 6114-6119 JJR denotes fewer
T18331 6120-6128 JJ denotes immature
T18330 6129-6134 NNS denotes cells
T18332 6135-6137 IN denotes in
T18333 6138-6141 DT denotes the
T18335 6142-6147 JJR denotes older
T18336 6148-6154 JJ denotes mutant
T18334 6155-6161 NN denotes thymus
T18337 6161-6162 . denotes .
T18338 6162-6447 sentence denotes Collectively, these results suggest that loss of Apc and consequent stabilization of β-catenin in K14-expressing TECs lead to their aberrant proliferation and differentiation to keratinocytes, causing massive squamous metaplasia, rather than to form either medullary or cortical TECs.
T18339 6163-6175 RB denotes Collectively
T18341 6175-6177 , denotes ,
T18342 6177-6182 DT denotes these
T18343 6183-6190 NNS denotes results
T18340 6191-6198 VBP denotes suggest
T18344 6199-6203 IN denotes that
T18346 6204-6208 NN denotes loss
T18347 6209-6211 IN denotes of
T18348 6212-6215 NN denotes Apc
T18349 6216-6219 CC denotes and
T18350 6220-6230 JJ denotes consequent
T18351 6231-6244 NN denotes stabilization
T18352 6245-6247 IN denotes of
T18353 6248-6249 NN denotes β
T18355 6249-6250 HYPH denotes -
T18354 6250-6257 NN denotes catenin
T18356 6258-6260 IN denotes in
T18357 6261-6264 NN denotes K14
T18359 6264-6265 HYPH denotes -
T18358 6265-6275 VBG denotes expressing
T18360 6276-6280 NNS denotes TECs
T18345 6281-6285 VBP denotes lead
T18361 6286-6288 IN denotes to
T18362 6289-6294 PRP$ denotes their
T18364 6295-6303 JJ denotes aberrant
T18363 6304-6317 NN denotes proliferation
T18365 6318-6321 CC denotes and
T18366 6322-6337 NN denotes differentiation
T18367 6338-6340 IN denotes to
T18368 6341-6354 NNS denotes keratinocytes
T18369 6354-6356 , denotes ,
T18370 6356-6363 VBG denotes causing
T18371 6364-6371 JJ denotes massive
T18373 6372-6380 JJ denotes squamous
T18372 6381-6391 NN denotes metaplasia
T18374 6391-6393 , denotes ,
T18375 6393-6399 IN denotes rather
T18376 6400-6404 IN denotes than
T18377 6405-6407 TO denotes to
T18378 6408-6412 VB denotes form
T18379 6413-6419 CC denotes either
T18380 6420-6429 JJ denotes medullary
T18382 6430-6432 CC denotes or
T18383 6433-6441 JJ denotes cortical
T18381 6442-6446 NNS denotes TECs
T18384 6446-6447 . denotes .
T18385 6447-6568 sentence denotes Loss of proper TEC compartments consequently resulted in loss of thymocytes for maturation and the mice to be “athymic.”
T18386 6448-6452 NN denotes Loss
T18388 6453-6455 IN denotes of
T18389 6456-6462 JJ denotes proper
T18391 6463-6466 NN denotes TEC
T18390 6467-6479 NNS denotes compartments
T18392 6480-6492 RB denotes consequently
T18387 6493-6501 VBD denotes resulted
T18393 6502-6504 IN denotes in
T18394 6505-6509 NN denotes loss
T18395 6510-6512 IN denotes of
T18396 6513-6523 NNS denotes thymocytes
T18397 6524-6527 IN denotes for
T18398 6528-6538 NN denotes maturation
T18399 6539-6542 CC denotes and
T18400 6543-6546 DT denotes the
T18401 6547-6551 NNS denotes mice
T18403 6552-6554 TO denotes to
T18402 6555-6557 VB denotes be
T18404 6558-6559 `` denotes “
T18405 6559-6566 JJ denotes athymic
T18406 6566-6567 . denotes .
T18407 6567-6568 '' denotes ”
R4564 T17241 T17242 compound K14,cre
R4565 T17242 T17244 npadvmod cre,Driven
R4566 T17243 T17242 punct -,cre
R4567 T17244 T17246 amod Driven,Loss
R4568 T17245 T17244 punct –,Driven
R4569 T17246 T17248 nsubj Loss,Results
R4570 T17247 T17246 compound Apc,Loss
R4571 T17249 T17248 prep in,Results
R4572 T17250 T17251 amod Hypoplastic,Athymic
R4573 T17251 T17253 amod Athymic,Mice
R4574 T17252 T17251 punct /,Athymic
R4575 T17253 T17249 pobj Mice,in
R4576 T17255 T17256 nsubj Thymus,is
R4577 T17257 T17258 det an,organ
R4578 T17258 T17256 attr organ,is
R4579 T17259 T17260 dep that,known
R4580 T17260 T17258 relcl known,organ
R4581 T17261 T17260 auxpass is,known
R4582 T17262 T17260 advmod also,known
R4583 T17263 T17264 aux to,have
R4584 T17264 T17260 xcomp have,known
R4585 T17265 T17266 compound K14,expression
R4586 T17266 T17264 dobj expression,have
R4587 T17267 T17268 punct [,16
R4588 T17268 T17258 parataxis 16,organ
R4589 T17269 T17268 punct ],16
R4590 T17270 T17256 punct .,is
R4591 T17272 T17273 nsubj It,represents
R4592 T17274 T17275 det the,organ
R4593 T17275 T17273 dobj organ,represents
R4594 T17276 T17275 amod primary,organ
R4595 T17277 T17275 amod lymphoid,organ
R4596 T17278 T17275 prep for,organ
R4597 T17279 T17280 compound thymocyte,development
R4598 T17280 T17278 pobj development,for
R4599 T17281 T17280 cc and,development
R4600 T17282 T17280 conj selection,development
R4601 T17283 T17273 punct .,represents
R4602 T17285 T17286 amod Distinct,population
R4603 T17286 T17287 nsubj population,mediates
R4604 T17288 T17286 prep of,population
R4605 T17289 T17288 pobj TECs,of
R4606 T17290 T17289 prep of,TECs
R4607 T17291 T17290 pobj cortex,of
R4608 T17292 T17291 cc and,cortex
R4609 T17293 T17291 conj medulla,cortex
R4610 T17294 T17287 dobj both,mediates
R4611 T17295 T17294 prep of,both
R4612 T17296 T17297 det these,functions
R4613 T17297 T17295 pobj functions,of
R4614 T17298 T17297 amod critical,functions
R4615 T17299 T17287 punct .,mediates
R4616 T17301 T17302 amod Cortical,subsets
R4617 T17302 T17306 nsubjpass subsets,characterized
R4618 T17303 T17301 cc and,Cortical
R4619 T17304 T17301 conj medullary,Cortical
R4620 T17305 T17302 compound TEC,subsets
R4621 T17307 T17306 auxpass are,characterized
R4622 T17308 T17306 agent by,characterized
R4623 T17309 T17310 amod differential,expression
R4624 T17310 T17308 pobj expression,by
R4625 T17311 T17310 prep of,expression
R4626 T17312 T17313 nummod four,species
R4627 T17313 T17311 pobj species,of
R4628 T17314 T17313 compound keratin,species
R4629 T17315 T17313 punct : ,species
R4630 T17316 T17313 appos K8,species
R4631 T17317 T17316 punct ", ",K8
R4632 T17318 T17316 conj K18,K8
R4633 T17319 T17318 punct ", ",K18
R4634 T17320 T17318 conj K5,K18
R4635 T17321 T17320 punct ", ",K5
R4636 T17322 T17320 cc and,K5
R4637 T17323 T17320 conj K14,K5
R4638 T17324 T17306 punct .,characterized
R4639 T17326 T17327 det The,thymus
R4640 T17327 T17329 nsubj thymus,is
R4641 T17328 T17327 amod normal,thymus
R4642 T17330 T17331 det a,organ
R4643 T17331 T17329 attr organ,is
R4644 T17332 T17331 amod lobulated,organ
R4645 T17333 T17331 amod lymphoid,organ
R4646 T17334 T17329 punct ", ",is
R4647 T17335 T17336 det each,lobule
R4648 T17336 T17337 nsubj lobule,showing
R4649 T17337 T17329 advcl showing,is
R4650 T17338 T17337 advmod clearly,showing
R4651 T17339 T17340 det the,compartments
R4652 T17340 T17337 dobj compartments,showing
R4653 T17341 T17340 nummod two,compartments
R4654 T17342 T17340 amod distinct,compartments
R4655 T17343 T17340 compound TEC,compartments
R4656 T17344 T17340 punct ", ",compartments
R4657 T17345 T17346 det an,cortex
R4658 T17346 T17340 appos cortex,compartments
R4659 T17347 T17346 amod outer,cortex
R4660 T17348 T17346 cc and,cortex
R4661 T17349 T17350 det an,medulla
R4662 T17350 T17346 conj medulla,cortex
R4663 T17351 T17350 amod inner,medulla
R4664 T17352 T17353 punct (,Figure
R4665 T17353 T17329 parataxis Figure,is
R4666 T17354 T17353 nummod 6,Figure
R4667 T17355 T17353 punct ),Figure
R4668 T17356 T17329 punct .,is
R4669 T17358 T17359 expl There,were
R4670 T17360 T17361 det no,differences
R4671 T17361 T17359 attr differences,were
R4672 T17362 T17361 amod major,differences
R4673 T17363 T17361 prep in,differences
R4674 T17364 T17365 det the,histology
R4675 T17365 T17363 pobj histology,in
R4676 T17366 T17365 prep of,histology
R4677 T17367 T17366 pobj thymus,of
R4678 T17368 T17359 prep between,were
R4679 T17369 T17370 det the,ages
R4680 T17370 T17368 pobj ages,between
R4681 T17371 T17370 appos P3,ages
R4682 T17372 T17371 prep to,P3
R4683 T17373 T17372 pobj P17,to
R4684 T17374 T17359 prep in,were
R4685 T17375 T17376 advmod phenotypically,normal
R4686 T17376 T17377 amod normal,littermates
R4687 T17377 T17374 pobj littermates,in
R4688 T17378 T17359 punct .,were
R4689 T17380 T17381 mark As,shown
R4690 T17381 T17382 advcl shown,formed
R4691 T17383 T17381 prep in,shown
R4692 T17384 T17385 det the,staining
R4693 T17385 T17383 pobj staining,in
R4694 T17386 T17385 nmod H,staining
R4695 T17387 T17386 cc &,H
R4696 T17388 T17386 conj E,H
R4697 T17389 T17385 prep of,staining
R4698 T17390 T17389 pobj thymus,of
R4699 T17391 T17382 punct ", ",formed
R4700 T17392 T17393 det the,cortex
R4701 T17393 T17382 nsubjpass cortex,formed
R4702 T17394 T17382 auxpass was,formed
R4703 T17395 T17382 prep of,formed
R4704 T17396 T17397 amod dense,tissue
R4705 T17397 T17395 pobj tissue,of
R4706 T17398 T17397 amod lymphoid,tissue
R4707 T17399 T17400 dep that,lacks
R4708 T17400 T17397 relcl lacks,tissue
R4709 T17401 T17400 dobj nodules,lacks
R4710 T17402 T17403 punct (,6A
R4711 T17403 T17382 parataxis 6A,formed
R4712 T17404 T17403 compound Figure,6A
R4713 T17405 T17403 punct ),6A
R4714 T17406 T17382 punct .,formed
R4715 T17408 T17409 mark Since,is
R4716 T17409 T17415 advcl is,stained
R4717 T17410 T17411 det the,stroma
R4718 T17411 T17409 nsubj stroma,is
R4719 T17412 T17411 prep of,stroma
R4720 T17413 T17414 det the,medulla
R4721 T17414 T17412 pobj medulla,of
R4722 T17416 T17417 advmod less,heavily
R4723 T17417 T17418 advmod heavily,infiltrated
R4724 T17418 T17409 acomp infiltrated,is
R4725 T17419 T17418 prep with,infiltrated
R4726 T17420 T17419 pobj lymphocytes,with
R4727 T17421 T17418 prep than,infiltrated
R4728 T17422 T17423 det the,cortex
R4729 T17423 T17421 pobj cortex,than
R4730 T17424 T17415 punct ", ",stained
R4731 T17425 T17426 det the,medulla
R4732 T17426 T17415 nsubj medulla,stained
R4733 T17427 T17428 advmod more,lightly
R4734 T17428 T17415 advmod lightly,stained
R4735 T17429 T17428 prep than,lightly
R4736 T17430 T17431 det the,cortex
R4737 T17431 T17429 pobj cortex,than
R4738 T17432 T17415 punct .,stained
R4739 T17434 T17435 prep In,retains
R4740 T17436 T17437 amod normal,mice
R4741 T17437 T17434 pobj mice,In
R4742 T17438 T17435 punct ", ",retains
R4743 T17439 T17440 det the,thymus
R4744 T17440 T17435 nsubj thymus,retains
R4745 T17441 T17442 poss its,size
R4746 T17442 T17435 dobj size,retains
R4747 T17443 T17435 prep until,retains
R4748 T17444 T17445 det the,age
R4749 T17445 T17443 pobj age,until
R4750 T17446 T17447 amod young,adult
R4751 T17447 T17445 nmod adult,age
R4752 T17448 T17435 cc and,retains
R4753 T17449 T17435 conj regresses,retains
R4754 T17450 T17449 advmod thereafter,regresses
R4755 T17451 T17449 prep by,regresses
R4756 T17452 T17451 pobj atrophy,by
R4757 T17453 T17435 punct .,retains
R4758 T17455 T17456 prep In,is
R4759 T17457 T17458 det the,mice
R4760 T17458 T17455 pobj mice,In
R4761 T17459 T17458 amod normal,mice
R4762 T17460 T17458 amod young,mice
R4763 T17461 T17462 nsubj we,examined
R4764 T17462 T17458 advcl examined,mice
R4765 T17463 T17464 punct (,P3
R4766 T17464 T17458 parataxis P3,mice
R4767 T17465 T17466 punct –,P17
R4768 T17466 T17464 prep P17,P3
R4769 T17467 T17464 punct ),P3
R4770 T17468 T17456 punct ", ",is
R4771 T17469 T17456 nsubj it,is
R4772 T17470 T17456 acomp evident,is
R4773 T17471 T17472 mark that,were
R4774 T17472 T17456 ccomp were,is
R4775 T17473 T17472 nsubj thymocytes,were
R4776 T17474 T17475 advmod mitotically,active
R4777 T17475 T17472 acomp active,were
R4778 T17476 T17472 prep in,were
R4779 T17477 T17478 det the,cortex
R4780 T17478 T17476 pobj cortex,in
R4781 T17479 T17480 mark as,determined
R4782 T17480 T17472 advcl determined,were
R4783 T17481 T17480 prep by,determined
R4784 T17482 T17483 compound BrdU,immunostaining
R4785 T17483 T17481 pobj immunostaining,by
R4786 T17484 T17485 punct (,6B
R4787 T17485 T17456 parataxis 6B,is
R4788 T17486 T17485 compound Figure,6B
R4789 T17487 T17485 punct ),6B
R4790 T17488 T17456 punct .,is
R4791 T17490 T17491 nsubj Immunohistochemistry,showed
R4792 T17492 T17490 prep of,Immunohistochemistry
R4793 T17493 T17494 amod normal,thymus
R4794 T17494 T17492 pobj thymus,of
R4795 T17495 T17494 prep from,thymus
R4796 T17496 T17497 nmod P3,mice
R4797 T17497 T17495 pobj mice,from
R4798 T17498 T17496 prep to,P3
R4799 T17499 T17498 pobj P17,to
R4800 T17500 T17501 det a,pattern
R4801 T17501 T17491 dobj pattern,showed
R4802 T17502 T17501 amod similar,pattern
R4803 T17503 T17501 compound staining,pattern
R4804 T17504 T17501 prep for,pattern
R4805 T17505 T17504 pobj K14,for
R4806 T17506 T17507 mark in,restricted
R4807 T17507 T17491 advcl restricted,showed
R4808 T17508 T17507 mark that,restricted
R4809 T17509 T17510 poss its,expression
R4810 T17510 T17507 nsubjpass expression,restricted
R4811 T17511 T17507 auxpass was,restricted
R4812 T17512 T17507 prep to,restricted
R4813 T17513 T17514 det a,population
R4814 T17514 T17512 pobj population,to
R4815 T17515 T17514 amod small,population
R4816 T17516 T17514 prep of,population
R4817 T17517 T17516 pobj TECs,of
R4818 T17518 T17514 prep in,population
R4819 T17519 T17520 det the,region
R4820 T17520 T17518 pobj region,in
R4821 T17521 T17520 amod inner,region
R4822 T17522 T17520 amod medullary,region
R4823 T17523 T17518 cc and,in
R4824 T17524 T17518 conj in,in
R4825 T17525 T17526 det the,keratinocytes
R4826 T17526 T17524 pobj keratinocytes,in
R4827 T17527 T17526 prep in,keratinocytes
R4828 T17528 T17529 poss Hassall,corpuscles
R4829 T17529 T17527 pobj corpuscles,in
R4830 T17530 T17528 case 's,Hassall
R4831 T17531 T17532 punct (,6D
R4832 T17532 T17491 parataxis 6D,showed
R4833 T17533 T17532 compound Figure,6D
R4834 T17534 T17532 punct ),6D
R4835 T17535 T17491 punct .,showed
R4836 T17537 T17538 amod Diffuse,staining
R4837 T17538 T17540 nsubjpass staining,detected
R4838 T17539 T17538 amod cytoplasmic,staining
R4839 T17541 T17538 prep for,staining
R4840 T17542 T17543 compound β,catenin
R4841 T17543 T17541 pobj catenin,for
R4842 T17544 T17543 punct -,catenin
R4843 T17545 T17540 auxpass was,detected
R4844 T17546 T17540 advmod also,detected
R4845 T17547 T17540 prep in,detected
R4846 T17548 T17549 det the,cells
R4847 T17549 T17547 pobj cells,in
R4848 T17550 T17549 amod medullary,cells
R4849 T17551 T17549 amod epithelial,cells
R4850 T17552 T17553 punct (,6C
R4851 T17553 T17540 parataxis 6C,detected
R4852 T17554 T17553 compound Figure,6C
R4853 T17555 T17553 punct ),6C
R4854 T17556 T17540 punct .,detected
R4855 T17558 T17559 prep In,observed
R4856 T17560 T17558 pobj contrast,In
R4857 T17561 T17560 prep to,contrast
R4858 T17562 T17563 compound K14,expression
R4859 T17563 T17561 pobj expression,to
R4860 T17564 T17559 punct ", ",observed
R4861 T17565 T17566 amod diffuse,staining
R4862 T17566 T17559 nsubjpass staining,observed
R4863 T17567 T17566 prep for,staining
R4864 T17568 T17567 pobj K8,for
R4865 T17569 T17559 auxpass was,observed
R4866 T17570 T17559 prep in,observed
R4867 T17571 T17572 amod epithelial,cells
R4868 T17572 T17570 pobj cells,in
R4869 T17573 T17574 preconj both,in
R4870 T17574 T17559 prep in,observed
R4871 T17575 T17576 det the,medulla
R4872 T17576 T17574 pobj medulla,in
R4873 T17577 T17576 cc and,medulla
R4874 T17578 T17576 conj cortex,medulla
R4875 T17579 T17580 punct (,S3
R4876 T17580 T17559 parataxis S3,observed
R4877 T17581 T17580 compound Figure,S3
R4878 T17582 T17580 punct ),S3
R4879 T17583 T17559 punct .,observed
R4880 T17585 T17586 compound K1,staining
R4881 T17586 T17587 nsubjpass staining,detected
R4882 T17588 T17587 auxpass was,detected
R4883 T17589 T17587 neg not,detected
R4884 T17590 T17587 prep in,detected
R4885 T17591 T17592 amod young,mice
R4886 T17592 T17590 pobj mice,in
R4887 T17593 T17587 prep at,detected
R4888 T17594 T17593 pobj P3,at
R4889 T17595 T17587 cc but,detected
R4890 T17596 T17597 prep in,detected
R4891 T17597 T17587 conj detected,detected
R4892 T17598 T17599 amod older,mice
R4893 T17599 T17596 pobj mice,in
R4894 T17600 T17597 nsubjpass it,detected
R4895 T17601 T17597 auxpass was,detected
R4896 T17602 T17597 prep in,detected
R4897 T17603 T17604 amod differentiated,keratinocytes
R4898 T17604 T17602 pobj keratinocytes,in
R4899 T17605 T17597 prep in,detected
R4900 T17606 T17605 pobj some,in
R4901 T17607 T17606 prep of,some
R4902 T17608 T17609 poss Hassall,corpuscles
R4903 T17609 T17607 pobj corpuscles,of
R4904 T17610 T17608 case 's,Hassall
R4905 T17611 T17612 punct (,S3
R4906 T17612 T17597 parataxis S3,detected
R4907 T17613 T17612 compound Figure,S3
R4908 T17614 T17612 punct ),S3
R4909 T17615 T17597 punct .,detected
R4910 T17617 T17618 det The,abnormalities
R4911 T17618 T17620 nsubj abnormalities,were
R4912 T17619 T17618 amod histological,abnormalities
R4913 T17621 T17618 prep of,abnormalities
R4914 T17622 T17621 pobj thymus,of
R4915 T17623 T17620 acomp evident,were
R4916 T17624 T17625 advmod as,early
R4917 T17625 T17620 advmod early,were
R4918 T17626 T17625 prep as,early
R4919 T17627 T17626 pobj P3,as
R4920 T17628 T17620 prep in,were
R4921 T17629 T17630 compound KA,mutants
R4922 T17630 T17628 pobj mutants,in
R4923 T17631 T17632 punct (,6E
R4924 T17632 T17620 parataxis 6E,were
R4925 T17633 T17632 compound Figure,6E
R4926 T17634 T17632 cc and,6E
R4927 T17635 T17632 conj 6H,6E
R4928 T17636 T17632 punct ),6E
R4929 T17637 T17620 punct .,were
R4930 T17639 T17640 det The,thymus
R4931 T17640 T17641 nsubjpass thymus,made
R4932 T17642 T17641 auxpass was,made
R4933 T17643 T17641 prep of,made
R4934 T17644 T17645 nummod two,lobules
R4935 T17645 T17643 pobj lobules,of
R4936 T17646 T17641 prep as,made
R4937 T17647 T17646 prep in,as
R4938 T17648 T17649 det the,mice
R4939 T17649 T17647 pobj mice,in
R4940 T17650 T17649 amod normal,mice
R4941 T17651 T17641 cc but,made
R4942 T17652 T17653 det the,thymus
R4943 T17653 T17655 nsubj thymus,was
R4944 T17654 T17653 amod mutant,thymus
R4945 T17655 T17641 conj was,made
R4946 T17656 T17657 advmod significantly,smaller
R4947 T17657 T17655 acomp smaller,was
R4948 T17658 T17657 prep in,smaller
R4949 T17659 T17658 pobj size,in
R4950 T17660 T17657 prep than,smaller
R4951 T17661 T17660 pobj that,than
R4952 T17662 T17661 prep of,that
R4953 T17663 T17664 det the,controls
R4954 T17664 T17662 pobj controls,of
R4955 T17665 T17666 npadvmod age,matched
R4956 T17666 T17664 amod matched,controls
R4957 T17667 T17666 punct -,matched
R4958 T17668 T17669 punct (,2G
R4959 T17669 T17655 parataxis 2G,was
R4960 T17670 T17669 compound Figure,2G
R4961 T17671 T17669 punct ),2G
R4962 T17672 T17655 punct .,was
R4963 T17674 T17675 advmod Interestingly,reflected
R4964 T17676 T17675 punct ", ",reflected
R4965 T17677 T17675 nsubjpass variations,reflected
R4966 T17678 T17677 prep in,variations
R4967 T17679 T17680 det the,severity
R4968 T17680 T17678 pobj severity,in
R4969 T17681 T17680 amod phenotypic,severity
R4970 T17682 T17680 prep of,severity
R4971 T17683 T17684 det the,pups
R4972 T17684 T17682 pobj pups,of
R4973 T17685 T17684 amod mutant,pups
R4974 T17686 T17677 prep at,variations
R4975 T17687 T17686 pobj P3,at
R4976 T17688 T17675 auxpass were,reflected
R4977 T17689 T17675 advmod prominently,reflected
R4978 T17690 T17675 prep in,reflected
R4979 T17691 T17692 det the,extent
R4980 T17692 T17690 pobj extent,in
R4981 T17693 T17692 prep of,extent
R4982 T17694 T17695 amod histological,abnormalities
R4983 T17695 T17693 pobj abnormalities,of
R4984 T17696 T17695 prep of,abnormalities
R4985 T17697 T17696 pobj thymus,of
R4986 T17698 T17675 punct .,reflected
R4987 T17700 T17701 det A,pup
R4988 T17701 T17705 nsubj pup,showed
R4989 T17702 T17701 nmod P3,pup
R4990 T17703 T17701 nmod KA,pup
R4991 T17704 T17701 amod mutant,pup
R4992 T17706 T17707 dep that,showed
R4993 T17707 T17701 relcl showed,pup
R4994 T17708 T17709 amod milder,phenotype
R4995 T17709 T17707 dobj phenotype,showed
R4996 T17710 T17709 prep with,phenotype
R4997 T17711 T17712 det a,weight
R4998 T17712 T17710 pobj weight,with
R4999 T17713 T17712 amod comparable,weight
R5000 T17714 T17712 compound body,weight
R5001 T17715 T17712 prep to,weight
R5002 T17716 T17717 poss its,littermates
R5003 T17717 T17715 pobj littermates,to
R5004 T17718 T17717 amod normal,littermates
R5005 T17719 T17720 punct (,2A
R5006 T17720 T17707 parataxis 2A,showed
R5007 T17721 T17720 compound Figure,2A
R5008 T17722 T17720 punct ", ",2A
R5009 T17723 T17720 npadvmod M2,2A
R5010 T17724 T17720 punct ),2A
R5011 T17725 T17726 amod milder,abnormalities
R5012 T17726 T17705 dobj abnormalities,showed
R5013 T17727 T17726 compound thymus,abnormalities
R5014 T17728 T17729 punct (,6E
R5015 T17729 T17726 parataxis 6E,abnormalities
R5016 T17730 T17729 compound Figure,6E
R5017 T17731 T17729 punct ),6E
R5018 T17732 T17705 prep compared,showed
R5019 T17733 T17732 prep to,compared
R5020 T17734 T17735 poss its,littermate
R5021 T17735 T17733 pobj littermate,to
R5022 T17736 T17737 advmod more,severe
R5023 T17737 T17735 amod severe,littermate
R5024 T17738 T17735 amod mutant,littermate
R5025 T17739 T17740 punct (,2A
R5026 T17740 T17705 parataxis 2A,showed
R5027 T17741 T17740 compound Figure,2A
R5028 T17742 T17740 punct ", ",2A
R5029 T17743 T17740 npadvmod M1,2A
R5030 T17744 T17740 punct ;,2A
R5031 T17745 T17746 compound Figure,6H
R5032 T17746 T17740 appos 6H,2A
R5033 T17747 T17740 punct ),2A
R5034 T17748 T17705 punct .,showed
R5035 T17750 T17751 det The,thymus
R5036 T17751 T17755 nsubj thymus,was
R5037 T17752 T17751 amod milder,thymus
R5038 T17753 T17751 nmod P3,thymus
R5039 T17754 T17751 amod mutant,thymus
R5040 T17756 T17755 advmod already,was
R5041 T17757 T17758 advmod much,smaller
R5042 T17758 T17755 acomp smaller,was
R5043 T17759 T17758 prep in,smaller
R5044 T17760 T17759 pobj size,in
R5045 T17761 T17755 prep compared,was
R5046 T17762 T17761 prep to,compared
R5047 T17763 T17762 pobj those,to
R5048 T17764 T17763 prep of,those
R5049 T17765 T17766 amod normal,littermates
R5050 T17766 T17764 pobj littermates,of
R5051 T17767 T17768 punct (,shown
R5052 T17768 T17755 parataxis shown,was
R5053 T17769 T17768 nsubj data,shown
R5054 T17770 T17768 neg not,shown
R5055 T17771 T17768 punct ),shown
R5056 T17772 T17755 cc but,was
R5057 T17773 T17774 nummod two,compartments
R5058 T17774 T17776 nsubj compartments,were
R5059 T17775 T17774 amod epithelial,compartments
R5060 T17776 T17755 conj were,was
R5061 T17777 T17774 prep of,compartments
R5062 T17778 T17777 pobj thymus,of
R5063 T17779 T17776 advmod histologically,were
R5064 T17780 T17776 advmod still,were
R5065 T17781 T17776 acomp distinguishable,were
R5066 T17782 T17776 punct ", ",were
R5067 T17783 T17784 mark with,evident
R5068 T17784 T17776 advcl evident,were
R5069 T17785 T17784 nsubj colonization,evident
R5070 T17786 T17785 prep of,colonization
R5071 T17787 T17786 pobj thymocytes,of
R5072 T17788 T17784 prep in,evident
R5073 T17789 T17790 det the,cortex
R5074 T17790 T17788 pobj cortex,in
R5075 T17791 T17776 punct .,were
R5076 T17793 T17794 advmod However,were
R5077 T17795 T17794 punct ", ",were
R5078 T17796 T17794 expl there,were
R5079 T17797 T17798 amod small,populations
R5080 T17798 T17794 attr populations,were
R5081 T17799 T17798 prep of,populations
R5082 T17800 T17801 advmod lightly,stained
R5083 T17801 T17802 amod stained,cells
R5084 T17802 T17799 pobj cells,of
R5085 T17803 T17798 prep by,populations
R5086 T17804 T17803 pobj H,by
R5087 T17805 T17804 cc &,H
R5088 T17806 T17804 conj E,H
R5089 T17807 T17798 acl extending,populations
R5090 T17808 T17807 prep from,extending
R5091 T17809 T17810 det the,edge
R5092 T17810 T17808 pobj edge,from
R5093 T17811 T17810 prep of,edge
R5094 T17812 T17813 det the,cortex
R5095 T17813 T17811 pobj cortex,of
R5096 T17814 T17813 amod outer,cortex
R5097 T17815 T17807 prep towards,extending
R5098 T17816 T17817 amod inner,medulla
R5099 T17817 T17815 pobj medulla,towards
R5100 T17818 T17819 punct (,6E
R5101 T17819 T17794 parataxis 6E,were
R5102 T17820 T17819 compound Figure,6E
R5103 T17821 T17819 punct ),6E
R5104 T17822 T17794 punct ", ",were
R5105 T17823 T17794 cc and,were
R5106 T17824 T17825 det these,cells
R5107 T17825 T17826 nsubj cells,showed
R5108 T17826 T17794 conj showed,were
R5109 T17827 T17828 amod intense,staining
R5110 T17828 T17826 dobj staining,showed
R5111 T17829 T17828 amod nuclear,staining
R5112 T17830 T17831 compound β,catenin
R5113 T17831 T17828 compound catenin,staining
R5114 T17832 T17831 punct -,catenin
R5115 T17833 T17834 mark whereas,showed
R5116 T17834 T17826 advcl showed,showed
R5117 T17835 T17836 det the,rest
R5118 T17836 T17834 nsubj rest,showed
R5119 T17837 T17836 prep of,rest
R5120 T17838 T17839 det the,cells
R5121 T17839 T17837 pobj cells,of
R5122 T17840 T17839 amod medullary,cells
R5123 T17841 T17842 amod diffuse,pattern
R5124 T17842 T17834 dobj pattern,showed
R5125 T17843 T17844 compound β,catenin
R5126 T17844 T17842 compound catenin,pattern
R5127 T17845 T17844 punct -,catenin
R5128 T17846 T17842 compound staining,pattern
R5129 T17847 T17842 amod similar,pattern
R5130 T17848 T17847 prep to,similar
R5131 T17849 T17848 pobj that,to
R5132 T17850 T17849 prep of,that
R5133 T17851 T17852 det the,control
R5134 T17852 T17850 pobj control,of
R5135 T17853 T17854 punct (,6F
R5136 T17854 T17826 parataxis 6F,showed
R5137 T17855 T17854 compound Figure,6F
R5138 T17856 T17854 punct ),6F
R5139 T17857 T17826 punct .,showed
R5140 T17859 T17860 nsubjpass Localization,limited
R5141 T17861 T17859 prep of,Localization
R5142 T17862 T17861 pobj K14,of
R5143 T17863 T17860 auxpass was,limited
R5144 T17864 T17860 prep to,limited
R5145 T17865 T17866 det a,cells
R5146 T17866 T17864 pobj cells,to
R5147 T17867 T17866 amod few,cells
R5148 T17868 T17866 prep in,cells
R5149 T17869 T17870 det the,medulla
R5150 T17870 T17868 pobj medulla,in
R5151 T17871 T17860 cc and,limited
R5152 T17872 T17873 nsubj some,overlapped
R5153 T17873 T17860 conj overlapped,limited
R5154 T17874 T17873 prep with,overlapped
R5155 T17875 T17876 compound K8,localization
R5156 T17876 T17874 pobj localization,with
R5157 T17877 T17878 punct (,6G
R5158 T17878 T17873 parataxis 6G,overlapped
R5159 T17879 T17878 compound Figure,6G
R5160 T17880 T17878 punct ),6G
R5161 T17881 T17873 punct .,overlapped
R5162 T17883 T17884 prep In,lost
R5163 T17885 T17886 det the,thymus
R5164 T17886 T17883 pobj thymus,In
R5165 T17887 T17886 amod other,thymus
R5166 T17888 T17886 nmod P3,thymus
R5167 T17889 T17886 amod mutant,thymus
R5168 T17890 T17891 det the,compartments
R5169 T17891 T17884 nsubjpass compartments,lost
R5170 T17892 T17891 amod distinct,compartments
R5171 T17893 T17894 amod thymic,epithelial
R5172 T17894 T17891 amod epithelial,compartments
R5173 T17895 T17884 aux have,lost
R5174 T17896 T17884 auxpass been,lost
R5175 T17897 T17884 advmod completely,lost
R5176 T17898 T17884 punct ", ",lost
R5177 T17899 T17884 cc and,lost
R5178 T17900 T17901 advmod only,lymphocytes
R5179 T17901 T17904 nsubj lymphocytes,remaining
R5180 T17902 T17901 det a,lymphocytes
R5181 T17903 T17901 amod few,lymphocytes
R5182 T17904 T17884 conj remaining,lost
R5183 T17905 T17904 aux were,remaining
R5184 T17906 T17904 prep at,remaining
R5185 T17907 T17908 det the,edges
R5186 T17908 T17906 pobj edges,at
R5187 T17909 T17904 cc and,remaining
R5188 T17910 T17904 conj some,remaining
R5189 T17911 T17910 prep in,some
R5190 T17912 T17913 det the,middle
R5191 T17913 T17911 pobj middle,in
R5192 T17914 T17915 punct (,6H
R5193 T17915 T17910 parataxis 6H,some
R5194 T17916 T17915 compound Figure,6H
R5195 T17917 T17915 punct ),6H
R5196 T17918 T17904 punct .,remaining
R5197 T17920 T17921 amod Proliferative,activities
R5198 T17921 T17922 nsubjpass activities,observed
R5199 T17923 T17922 auxpass were,observed
R5200 T17924 T17925 neg no,longer
R5201 T17925 T17922 advmod longer,observed
R5202 T17926 T17922 prep in,observed
R5203 T17927 T17926 pobj thymocytes,in
R5204 T17928 T17929 advmod as,prominently
R5205 T17929 T17922 advmod prominently,observed
R5206 T17930 T17929 prep as,prominently
R5207 T17931 T17930 prep in,as
R5208 T17932 T17933 det the,thymus
R5209 T17933 T17931 pobj thymus,in
R5210 T17934 T17933 amod normal,thymus
R5211 T17935 T17922 punct ", ",observed
R5212 T17936 T17922 cc but,observed
R5213 T17937 T17938 det the,cells
R5214 T17938 T17940 nsubj cells,seemed
R5215 T17939 T17938 amod epithelial,cells
R5216 T17940 T17922 conj seemed,observed
R5217 T17941 T17942 aux to,forming
R5218 T17942 T17940 xcomp forming,seemed
R5219 T17943 T17942 aux be,forming
R5220 T17944 T17945 amod concentric,structures
R5221 T17945 T17942 dobj structures,forming
R5222 T17946 T17947 punct (,6I
R5223 T17947 T17942 parataxis 6I,forming
R5224 T17948 T17947 compound Figure,6I
R5225 T17949 T17947 punct ),6I
R5226 T17950 T17940 punct .,seemed
R5227 T17952 T17953 prep Unlike,showed
R5228 T17954 T17952 prep in,Unlike
R5229 T17955 T17956 det the,thymi
R5230 T17956 T17954 pobj thymi,in
R5231 T17957 T17956 amod normal,thymi
R5232 T17958 T17957 cc or,normal
R5233 T17959 T17957 conj mild,normal
R5234 T17960 T17956 amod mutant,thymi
R5235 T17961 T17953 punct ", ",showed
R5236 T17962 T17963 det the,thymus
R5237 T17963 T17953 nsubj thymus,showed
R5238 T17964 T17963 amod severe,thymus
R5239 T17965 T17963 nmod P3,thymus
R5240 T17966 T17963 amod mutant,thymus
R5241 T17967 T17968 amod extensive,expression
R5242 T17968 T17953 dobj expression,showed
R5243 T17969 T17968 compound K14,expression
R5244 T17970 T17971 dep that,overlapped
R5245 T17971 T17968 relcl overlapped,expression
R5246 T17972 T17971 prep with,overlapped
R5247 T17973 T17974 compound K8,expression
R5248 T17974 T17972 pobj expression,with
R5249 T17975 T17976 punct (,6K
R5250 T17976 T17953 parataxis 6K,showed
R5251 T17977 T17976 compound Figure,6K
R5252 T17978 T17976 punct ),6K
R5253 T17979 T17953 punct .,showed
R5254 T17981 T17982 det These,cells
R5255 T17982 T17983 nsubj cells,were
R5256 T17984 T17985 advmod more,like
R5257 T17985 T17983 prep like,were
R5258 T17986 T17987 amod basal,cells
R5259 T17987 T17985 pobj cells,like
R5260 T17988 T17987 prep of,cells
R5261 T17989 T17990 det the,skin
R5262 T17990 T17988 pobj skin,of
R5263 T17991 T17983 prep than,were
R5264 T17992 T17991 pobj TECs,than
R5265 T17993 T17983 cc and,were
R5266 T17994 T17983 conj were,were
R5267 T17995 T17994 acomp adjacent,were
R5268 T17996 T17995 prep to,adjacent
R5269 T17997 T17998 det the,cells
R5270 T17998 T17996 pobj cells,to
R5271 T17999 T18000 advmod most,immature
R5272 T18000 T17998 amod immature,cells
R5273 T18001 T17998 amod looking,cells
R5274 T18002 T18003 dep that,showing
R5275 T18003 T17998 relcl showing,cells
R5276 T18004 T18003 aux were,showing
R5277 T18005 T18006 amod strong,staining
R5278 T18006 T18003 dobj staining,showing
R5279 T18007 T18006 amod nuclear,staining
R5280 T18008 T18007 cc and,nuclear
R5281 T18009 T18007 conj cytoplasmic,nuclear
R5282 T18010 T18011 compound β,catenin
R5283 T18011 T18006 compound catenin,staining
R5284 T18012 T18011 punct -,catenin
R5285 T18013 T18014 punct (,6J
R5286 T18014 T17994 parataxis 6J,were
R5287 T18015 T18014 compound Figure,6J
R5288 T18016 T18014 punct ),6J
R5289 T18017 T17983 punct .,were
R5290 T18019 T18020 det The,staining
R5291 T18020 T18022 nsubjpass staining,observed
R5292 T18021 T18020 amod nuclear,staining
R5293 T18023 T18020 prep of,staining
R5294 T18024 T18025 compound β,catenin
R5295 T18025 T18023 pobj catenin,of
R5296 T18026 T18025 punct -,catenin
R5297 T18027 T18022 auxpass was,observed
R5298 T18028 T18022 neg not,observed
R5299 T18029 T18022 prep in,observed
R5300 T18030 T18031 det the,thymus
R5301 T18031 T18029 pobj thymus,in
R5302 T18032 T18031 amod normal,thymus
R5303 T18033 T18034 npadvmod age,matched
R5304 T18034 T18031 amod matched,thymus
R5305 T18035 T18034 punct -,matched
R5306 T18036 T18037 punct (,6C
R5307 T18037 T18022 parataxis 6C,observed
R5308 T18038 T18037 compound Figure,6C
R5309 T18039 T18037 punct ),6C
R5310 T18040 T18022 punct .,observed
R5311 T18042 T18043 advmod Most,notably
R5312 T18043 T18044 advmod notably,were
R5313 T18045 T18044 punct ", ",were
R5314 T18046 T18047 det the,patterns
R5315 T18047 T18044 nsubj patterns,were
R5316 T18048 T18047 nmod K14,patterns
R5317 T18049 T18048 cc and,K14
R5318 T18050 T18051 compound β,catenin
R5319 T18051 T18048 conj catenin,K14
R5320 T18052 T18051 punct -,catenin
R5321 T18053 T18047 compound staining,patterns
R5322 T18054 T18055 advmod mutually,exclusive
R5323 T18055 T18044 acomp exclusive,were
R5324 T18056 T18057 punct (,6J
R5325 T18057 T18044 parataxis 6J,were
R5326 T18058 T18057 compound Figure,6J
R5327 T18059 T18057 cc and,6J
R5328 T18060 T18057 conj 6K,6J
R5329 T18061 T18057 punct ),6J
R5330 T18062 T18044 punct .,were
R5331 T18064 T18065 prep At,consisted
R5332 T18066 T18064 pobj P10,At
R5333 T18067 T18068 punct –,P13
R5334 T18068 T18066 prep P13,P10
R5335 T18069 T18065 punct ", ",consisted
R5336 T18070 T18071 det the,thymus
R5337 T18071 T18065 nsubj thymus,consisted
R5338 T18072 T18071 amod mutant,thymus
R5339 T18073 T18065 prep of,consisted
R5340 T18074 T18075 amod numerous,structures
R5341 T18075 T18073 pobj structures,of
R5342 T18076 T18075 amod enlarged,structures
R5343 T18077 T18075 poss Hassall,structures
R5344 T18078 T18077 case 's,Hassall
R5345 T18079 T18080 npadvmod corpuscle,like
R5346 T18080 T18075 amod like,structures
R5347 T18081 T18080 punct –,like
R5348 T18082 T18075 punct ", ",structures
R5349 T18083 T18075 acl made,structures
R5350 T18084 T18083 prep of,made
R5351 T18085 T18084 pobj arrays,of
R5352 T18086 T18085 prep of,arrays
R5353 T18087 T18088 npadvmod K14,expressing
R5354 T18088 T18093 amod expressing,cells
R5355 T18089 T18087 punct -,K14
R5356 T18090 T18087 cc and,K14
R5357 T18137 T18138 npadvmod differentiation,specific
R5358 T18091 T18087 conj K8,K14
R5359 T18138 T18140 amod specific,markers
R5360 T18092 T18088 punct -,expressing
R5361 T18139 T18138 punct -,specific
R5362 T18140 T18136 pobj markers,of
R5363 T18093 T18086 pobj cells,of
R5364 T18141 T18140 prep depending,markers
R5365 T18142 T18141 prep on,depending
R5366 T18143 T18144 det the,age
R5367 T18094 T18093 amod keratinizing,cells
R5368 T18144 T18142 pobj age,on
R5369 T18145 T18144 prep of,age
R5370 T18095 T18093 amod epithelial,cells
R5371 T18146 T18145 pobj mice,of
R5372 T18147 T18140 punct ", ",markers
R5373 T18148 T18149 prep in,K1
R5374 T18096 T18093 acl surrounding,cells
R5375 T18149 T18140 appos K1,markers
R5376 T18150 T18151 det this,case
R5377 T18151 T18148 pobj case,in
R5378 T18097 T18098 amod large,deposits
R5379 T18098 T18096 dobj deposits,surrounding
R5380 T18152 T18149 cc and,K1
R5381 T18153 T18149 conj involucrin,K1
R5382 T18154 T18155 dep that,are
R5383 T18155 T18149 relcl are,K1
R5384 T18156 T18155 advmod normally,are
R5385 T18099 T18098 compound keratin,deposits
R5386 T18157 T18155 acomp present,are
R5387 T18158 T18159 advmod only,in
R5388 T18159 T18155 prep in,are
R5389 T18160 T18161 poss Hassall,corpuscles
R5390 T18100 T18101 punct (,6L
R5391 T18161 T18159 pobj corpuscles,in
R5392 T18162 T18160 case 's,Hassall
R5393 T18101 T18065 parataxis 6L,consisted
R5394 T18163 T18135 punct ", ",detected
R5395 T18164 T18135 auxpass were,detected
R5396 T18165 T18135 advmod also,detected
R5397 T18102 T18101 compound Figure,6L
R5398 T18166 T18135 prep in,detected
R5399 T18103 T18101 cc and,6L
R5400 T18167 T18168 amod mutant,thymi
R5401 T18168 T18166 pobj thymi,in
R5402 T18169 T18170 punct (,S3
R5403 T18170 T18135 parataxis S3,detected
R5404 T18171 T18170 compound Figure,S3
R5405 T18104 T18101 conj 6O,6L
R5406 T18172 T18170 punct ),S3
R5407 T18173 T18135 punct .,detected
R5408 T18105 T18101 punct ),6L
R5409 T18175 T18176 prep In,were
R5410 T18106 T18065 punct .,consisted
R5411 T18177 T18178 det these,mice
R5412 T18178 T18175 pobj mice,In
R5413 T18179 T18180 det no,thymocytes
R5414 T18108 T18109 expl There,were
R5415 T18180 T18176 nsubj thymocytes,were
R5416 T18181 T18176 acomp detectable,were
R5417 T18182 T18176 punct .,were
R5418 T18109 T18110 ccomp were,called
R5419 T18184 T18185 compound BrdU,incorporation
R5420 T18185 T18186 nsubjpass incorporation,looking
R5421 T18111 T18112 amod numerous,neutrophils
R5422 T18187 T18186 auxpass was,looking
R5423 T18188 T18186 advmod only,looking
R5424 T18189 T18186 aux observed,looking
R5425 T18190 T18186 prep in,looking
R5426 T18112 T18109 attr neutrophils,were
R5427 T18191 T18192 advmod very,few
R5428 T18192 T18193 amod few,cells
R5429 T18113 T18112 cc and,neutrophils
R5430 T18193 T18190 pobj cells,in
R5431 T18194 T18193 amod keratinizing,cells
R5432 T18195 T18193 amod epithelial,cells
R5433 T18114 T18112 conj macrophages,neutrophils
R5434 T18196 T18186 punct ", ",looking
R5435 T18197 T18198 advmod somewhat,similar
R5436 T18198 T18186 acomp similar,looking
R5437 T18199 T18198 prep to,similar
R5438 T18200 T18201 det the,pattern
R5439 T18201 T18199 pobj pattern,to
R5440 T18115 T18112 acl infiltrating,neutrophils
R5441 T18202 T18201 prep of,pattern
R5442 T18203 T18204 amod mature,skin
R5443 T18204 T18202 pobj skin,of
R5444 T18116 T18117 det the,thymus
R5445 T18205 T18206 punct (,6M
R5446 T18206 T18186 parataxis 6M,looking
R5447 T18207 T18206 compound Figure,6M
R5448 T18208 T18206 punct ),6M
R5449 T18117 T18115 dobj thymus,infiltrating
R5450 T18209 T18186 punct .,looking
R5451 T18118 T18115 prep in,infiltrating
R5452 T18211 T18212 det The,expression
R5453 T18212 T18214 nsubj expression,was
R5454 T18213 T18212 amod diffuse,expression
R5455 T18119 T18118 pobj response,in
R5456 T18215 T18212 prep of,expression
R5457 T18120 T18119 prep to,response
R5458 T18216 T18217 compound β,catenin
R5459 T18217 T18215 pobj catenin,of
R5460 T18218 T18217 punct -,catenin
R5461 T18121 T18122 det these,keratins
R5462 T18219 T18214 advmod also,was
R5463 T18220 T18214 acomp present,was
R5464 T18221 T18214 prep in,was
R5465 T18122 T18120 pobj keratins,to
R5466 T18222 T18223 det these,cells
R5467 T18223 T18221 pobj cells,in
R5468 T18224 T18223 amod epithelial,cells
R5469 T18123 T18110 punct ;,called
R5470 T18225 T18214 punct ", ",was
R5471 T18226 T18214 cc and,was
R5472 T18227 T18228 prep at,were
R5473 T18124 T18110 advmod hence,called
R5474 T18228 T18214 conj were,was
R5475 T18229 T18230 det this,age
R5476 T18230 T18227 pobj age,at
R5477 T18231 T18232 amod fewer,cells
R5478 T18125 T18110 punct ", ",called
R5479 T18232 T18228 nsubj cells,were
R5480 T18233 T18228 acomp positive,were
R5481 T18126 T18127 det these,structures
R5482 T18234 T18233 prep for,positive
R5483 T18235 T18236 amod nuclear,staining
R5484 T18127 T18110 nsubjpass structures,called
R5485 T18236 T18234 pobj staining,for
R5486 T18237 T18238 compound β,catenin
R5487 T18238 T18236 compound catenin,staining
R5488 T18239 T18238 punct -,catenin
R5489 T18128 T18110 aux could,called
R5490 T18240 T18241 punct (,6N
R5491 T18241 T18228 parataxis 6N,were
R5492 T18242 T18241 compound Figure,6N
R5493 T18129 T18110 auxpass be,called
R5494 T18130 T18110 oprd pyogranuloma,called
R5495 T18131 T18110 punct .,called
R5496 T18133 T18134 amod Varying,degrees
R5497 T18243 T18241 punct ),6N
R5498 T18134 T18135 nsubjpass degrees,detected
R5499 T18244 T18228 punct .,were
R5500 T18246 T18247 prep As,observed
R5501 T18136 T18134 prep of,degrees
R5502 T18248 T18246 prep in,As
R5503 T18249 T18250 det the,mice
R5504 T18349 T18346 cc and,loss
R5505 T18250 T18248 pobj mice,in
R5506 T18251 T18250 amod younger,mice
R5507 T18252 T18250 amod mutant,mice
R5508 T18253 T18247 punct ", ",observed
R5509 T18350 T18351 amod consequent,stabilization
R5510 T18254 T18247 advmod however,observed
R5511 T18255 T18247 punct ", ",observed
R5512 T18351 T18346 conj stabilization,loss
R5513 T18256 T18257 amod nuclear,localization
R5514 T18257 T18247 nsubjpass localization,observed
R5515 T18258 T18257 prep of,localization
R5516 T18352 T18351 prep of,stabilization
R5517 T18259 T18260 compound β,catenin
R5518 T18260 T18258 pobj catenin,of
R5519 T18261 T18260 punct -,catenin
R5520 T18353 T18354 compound β,catenin
R5521 T18262 T18247 auxpass was,observed
R5522 T18263 T18247 advmod only,observed
R5523 T18264 T18247 prep in,observed
R5524 T18354 T18352 pobj catenin,of
R5525 T18265 T18266 npadvmod K14,negative
R5526 T18266 T18268 amod negative,cells
R5527 T18267 T18266 punct -,negative
R5528 T18268 T18264 pobj cells,in
R5529 T18355 T18354 punct -,catenin
R5530 T18269 T18270 dep that,looked
R5531 T18270 T18268 relcl looked,cells
R5532 T18356 T18346 prep in,loss
R5533 T18271 T18270 prep like,looked
R5534 T18272 T18273 amod undifferentiated,cells
R5535 T18273 T18271 pobj cells,like
R5536 T18357 T18358 npadvmod K14,expressing
R5537 T18274 T18273 amod basal,cells
R5538 T18275 T18247 punct .,observed
R5539 T18277 T18278 prep In,was
R5540 T18279 T18280 amod older,mice
R5541 T18358 T18360 amod expressing,TECs
R5542 T18280 T18277 pobj mice,In
R5543 T18281 T18280 compound P17,mice
R5544 T18282 T18278 punct ", ",was
R5545 T18359 T18358 punct -,expressing
R5546 T18283 T18284 det the,histopathology
R5547 T18284 T18278 nsubj histopathology,was
R5548 T18285 T18284 cc and,histopathology
R5549 T18360 T18356 pobj TECs,in
R5550 T18286 T18287 compound keratin,pattern
R5551 T18287 T18284 conj pattern,histopathology
R5552 T18361 T18345 prep to,lead
R5553 T18288 T18287 compound expression,pattern
R5554 T18289 T18284 prep of,histopathology
R5555 T18290 T18291 det the,thymus
R5556 T18362 T18363 poss their,proliferation
R5557 T18291 T18289 pobj thymus,of
R5558 T18292 T18291 amod mutant,thymus
R5559 T18293 T18278 acomp similar,was
R5560 T18363 T18361 pobj proliferation,to
R5561 T18294 T18293 prep to,similar
R5562 T18295 T18294 pobj that,to
R5563 T18296 T18295 prep of,that
R5564 T18364 T18363 amod aberrant,proliferation
R5565 T18297 T18296 pobj P13,of
R5566 T18298 T18278 prep except,was
R5567 T18365 T18363 cc and,proliferation
R5568 T18299 T18298 prep for,except
R5569 T18300 T18301 det the,fact
R5570 T18301 T18299 pobj fact,for
R5571 T18302 T18303 mark that,became
R5572 T18366 T18363 conj differentiation,proliferation
R5573 T18303 T18301 acl became,fact
R5574 T18304 T18305 compound β,catenin
R5575 T18367 T18366 prep to,differentiation
R5576 T18305 T18307 compound catenin,expression
R5577 T18306 T18305 punct -,catenin
R5578 T18307 T18303 nsubj expression,became
R5579 T18368 T18367 pobj keratinocytes,to
R5580 T18308 T18309 advmod increasingly,diffuse
R5581 T18309 T18303 acomp diffuse,became
R5582 T18310 T18303 cc and,became
R5583 T18311 T18303 conj appeared,became
R5584 T18369 T18345 punct ", ",lead
R5585 T18312 T18313 aux to,colocalize
R5586 T18313 T18311 xcomp colocalize,appeared
R5587 T18370 T18345 advcl causing,lead
R5588 T18314 T18313 prep with,colocalize
R5589 T18315 T18316 compound K8,K14
R5590 T18316 T18318 compound K14,expression
R5591 T18317 T18316 punct /,K14
R5592 T18318 T18314 pobj expression,with
R5593 T18319 T18320 punct (,shown
R5594 T18371 T18372 amod massive,metaplasia
R5595 T18320 T18278 parataxis shown,was
R5596 T18321 T18320 nsubj data,shown
R5597 T18322 T18320 neg not,shown
R5598 T18372 T18370 dobj metaplasia,causing
R5599 T18373 T18372 amod squamous,metaplasia
R5600 T18323 T18320 punct ),shown
R5601 T18374 T18370 punct ", ",causing
R5602 T18324 T18278 punct .,was
R5603 T18375 T18370 cc rather,causing
R5604 T18326 T18327 nsubj This,coincided
R5605 T18376 T18375 dep than,rather
R5606 T18328 T18327 prep with,coincided
R5607 T18329 T18330 amod fewer,cells
R5608 T18330 T18328 pobj cells,with
R5609 T18377 T18378 aux to,form
R5610 T18331 T18330 amod immature,cells
R5611 T18332 T18330 prep in,cells
R5612 T18378 T18370 conj form,causing
R5613 T18333 T18334 det the,thymus
R5614 T18334 T18332 pobj thymus,in
R5615 T18379 T18380 preconj either,medullary
R5616 T18335 T18334 amod older,thymus
R5617 T18336 T18334 amod mutant,thymus
R5618 T18337 T18327 punct .,coincided
R5619 T18380 T18381 amod medullary,TECs
R5620 T18339 T18340 advmod Collectively,suggest
R5621 T18381 T18378 dobj TECs,form
R5622 T18341 T18340 punct ", ",suggest
R5623 T18342 T18343 det these,results
R5624 T18382 T18380 cc or,medullary
R5625 T18343 T18340 nsubj results,suggest
R5626 T18344 T18345 mark that,lead
R5627 T18383 T18380 conj cortical,medullary
R5628 T18345 T18340 ccomp lead,suggest
R5629 T18346 T18345 nsubj loss,lead
R5630 T18347 T18346 prep of,loss
R5631 T18384 T18340 punct .,suggest
R5632 T18348 T18347 pobj Apc,of
R5633 T18386 T18387 nsubj Loss,resulted
R5634 T18388 T18386 prep of,Loss
R5635 T18389 T18390 amod proper,compartments
R5636 T18390 T18388 pobj compartments,of
R5637 T18391 T18390 compound TEC,compartments
R5638 T18392 T18387 advmod consequently,resulted
R5639 T18393 T18387 prep in,resulted
R5640 T18394 T18393 pobj loss,in
R5641 T18395 T18394 prep of,loss
R5642 T18396 T18395 pobj thymocytes,of
R5643 T18397 T18396 prep for,thymocytes
R5644 T18398 T18397 pobj maturation,for
R5645 T18399 T18394 cc and,loss
R5646 T18400 T18401 det the,mice
R5647 T18401 T18402 nsubj mice,be
R5648 T18402 T18394 conj be,loss
R5649 T18403 T18402 aux to,be
R5650 T18404 T18405 punct “,athymic
R5651 T18405 T18402 acomp athymic,be
R5652 T18406 T18387 punct .,resulted
R5653 T18407 T18387 punct ”,resulted