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PMC:1564426 / 29273-30524 JSONTXT 3 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T14520 0-7 JJ denotes Similar
T14522 8-10 IN denotes to
T14523 11-14 DT denotes the
T14524 15-22 NN denotes biology
T14525 23-25 IN denotes of
T14526 26-30 NN denotes hair
T14527 31-40 NNS denotes follicles
T14528 40-42 , denotes ,
T14529 42-45 NN denotes K14
T14531 45-46 HYPH denotes -
T14530 46-49 NN denotes cre
T14533 49-50 HYPH denotes –
T14532 50-56 VBN denotes driven
T14534 57-61 NN denotes loss
T14535 62-64 IN denotes of
T14536 65-68 NN denotes Apc
T14537 69-73 RB denotes also
T14521 74-82 VBD denotes affected
T14538 83-86 DT denotes the
T14539 87-98 NN denotes development
T14540 99-101 IN denotes of
T14541 102-107 JJ denotes other
T14543 108-117 JJ denotes epidermal
T14542 118-128 NNS denotes appendages
T14544 129-133 WDT denotes that
T14545 134-140 VBP denotes depend
T14546 141-143 IN denotes on
T14547 144-154 JJ denotes epithelial
T14549 154-155 HYPH denotes –
T14548 155-166 JJ denotes mesenchymal
T14550 167-179 NNS denotes interactions
T14551 180-183 IN denotes for
T14552 184-189 PRP$ denotes their
T14553 190-199 NN denotes formation
T14554 199-200 . denotes .
T14555 200-264 sentence denotes The most striking of these was dental dysplasia (Figure 4K–4R).
T14556 201-204 DT denotes The
T14558 205-209 RBS denotes most
T14557 210-218 JJ denotes striking
T14560 219-221 IN denotes of
T14561 222-227 DT denotes these
T14559 228-231 VBD denotes was
T14562 232-238 JJ denotes dental
T14563 239-248 NN denotes dysplasia
T14564 249-250 -LRB- denotes (
T14566 250-256 NN denotes Figure
T14565 257-259 NN denotes 4K
T14567 259-260 SYM denotes –
T14568 260-262 NN denotes 4R
T14569 262-263 -RRB- denotes )
T14570 263-264 . denotes .
T14571 264-466 sentence denotes Tooth development is normally initiated between E11 and E12 by invagination of ectodermally derived oral epithelium into the underlying cranial neural crest–derived mesenchyme, generating a tooth germ.
T14572 265-270 NN denotes Tooth
T14573 271-282 NN denotes development
T14575 283-285 VBZ denotes is
T14576 286-294 RB denotes normally
T14574 295-304 VBN denotes initiated
T14577 305-312 IN denotes between
T14578 313-316 NN denotes E11
T14579 317-320 CC denotes and
T14580 321-324 NN denotes E12
T14581 325-327 IN denotes by
T14582 328-340 NN denotes invagination
T14583 341-343 IN denotes of
T14584 344-356 RB denotes ectodermally
T14585 357-364 VBN denotes derived
T14587 365-369 JJ denotes oral
T14586 370-380 NN denotes epithelium
T14588 381-385 IN denotes into
T14589 386-389 DT denotes the
T14591 390-400 VBG denotes underlying
T14592 401-408 JJ denotes cranial
T14594 409-415 JJ denotes neural
T14593 416-421 NN denotes crest
T14596 421-422 HYPH denotes –
T14595 422-429 VBN denotes derived
T14590 430-440 NN denotes mesenchyme
T14597 440-442 , denotes ,
T14598 442-452 VBG denotes generating
T14599 453-454 DT denotes a
T14601 455-460 JJ denotes tooth
T14600 461-465 NN denotes germ
T14602 465-466 . denotes .
T14603 466-630 sentence denotes Despite the grossly toothless phenotype of KA mutants, histological analysis of their oral cavities revealed the formation of multiple tooth buds at each location.
T14604 467-474 IN denotes Despite
T14606 475-478 DT denotes the
T14608 479-486 RB denotes grossly
T14609 487-496 JJ denotes toothless
T14607 497-506 NN denotes phenotype
T14610 507-509 IN denotes of
T14611 510-512 NN denotes KA
T14612 513-520 NNS denotes mutants
T14613 520-522 , denotes ,
T14614 522-534 JJ denotes histological
T14615 535-543 NN denotes analysis
T14616 544-546 IN denotes of
T14617 547-552 PRP$ denotes their
T14619 553-557 JJ denotes oral
T14618 558-566 NNS denotes cavities
T14605 567-575 VBD denotes revealed
T14620 576-579 DT denotes the
T14621 580-589 NN denotes formation
T14622 590-592 IN denotes of
T14623 593-601 JJ denotes multiple
T14625 602-607 JJ denotes tooth
T14624 608-612 NNS denotes buds
T14626 613-615 IN denotes at
T14627 616-620 DT denotes each
T14628 621-629 NN denotes location
T14629 629-630 . denotes .
T14630 630-735 sentence denotes These aberrant teeth obviously failed to grow out during the dietary transition from milk to solid food.
T14631 631-636 DT denotes These
T14633 637-645 JJ denotes aberrant
T14632 646-651 NNS denotes teeth
T14635 652-661 RB denotes obviously
T14634 662-668 VBD denotes failed
T14636 669-671 TO denotes to
T14637 672-676 VB denotes grow
T14638 677-680 RP denotes out
T14639 681-687 IN denotes during
T14640 688-691 DT denotes the
T14642 692-699 JJ denotes dietary
T14641 700-710 NN denotes transition
T14643 711-715 IN denotes from
T14644 716-720 NN denotes milk
T14645 721-723 IN denotes to
T14646 724-729 JJ denotes solid
T14647 730-734 NN denotes food
T14648 734-735 . denotes .
T14649 735-939 sentence denotes Analogous to the expression patterns of K14 and β-catenin in the normal skin, diffuse membrane-bound expression of β-catenin was detected in K14-expressing oral epithelium and ameloblasts of normal mice.
T14650 736-745 JJ denotes Analogous
T14652 746-748 IN denotes to
T14653 749-752 DT denotes the
T14655 753-763 NN denotes expression
T14654 764-772 NNS denotes patterns
T14656 773-775 IN denotes of
T14657 776-779 NN denotes K14
T14658 780-783 CC denotes and
T14659 784-785 NN denotes β
T14661 785-786 HYPH denotes -
T14660 786-793 NN denotes catenin
T14662 794-796 IN denotes in
T14663 797-800 DT denotes the
T14665 801-807 JJ denotes normal
T14664 808-812 NN denotes skin
T14666 812-814 , denotes ,
T14667 814-821 JJ denotes diffuse
T14669 822-830 NN denotes membrane
T14671 830-831 HYPH denotes -
T14670 831-836 VBN denotes bound
T14668 837-847 NN denotes expression
T14672 848-850 IN denotes of
T14673 851-852 NN denotes β
T14675 852-853 HYPH denotes -
T14674 853-860 NN denotes catenin
T14676 861-864 VBD denotes was
T14651 865-873 VBN denotes detected
T14677 874-876 IN denotes in
T14678 877-880 NN denotes K14
T14680 880-881 HYPH denotes -
T14679 881-891 VBG denotes expressing
T14682 892-896 JJ denotes oral
T14681 897-907 NN denotes epithelium
T14683 908-911 CC denotes and
T14684 912-923 NNS denotes ameloblasts
T14685 924-926 IN denotes of
T14686 927-933 JJ denotes normal
T14687 934-938 NNS denotes mice
T14688 938-939 . denotes .
T14689 939-1098 sentence denotes In mutants, some of the K14-expressing cells also showed strong cytosolic/nuclear β-catenin staining, as observed in the mutant skin (Figure 4Q, 4Q′, and 4R).
T14690 940-942 IN denotes In
T14692 943-950 NNS denotes mutants
T14693 950-952 , denotes ,
T14694 952-956 DT denotes some
T14695 957-959 IN denotes of
T14696 960-963 DT denotes the
T14698 964-967 NN denotes K14
T14700 967-968 HYPH denotes -
T14699 968-978 VBG denotes expressing
T14697 979-984 NNS denotes cells
T14701 985-989 RB denotes also
T14691 990-996 VBD denotes showed
T14702 997-1003 JJ denotes strong
T14704 1004-1013 JJ denotes cytosolic
T14706 1013-1014 HYPH denotes /
T14707 1014-1021 JJ denotes nuclear
T14705 1022-1023 NN denotes β
T14708 1023-1024 HYPH denotes -
T14709 1024-1031 NN denotes catenin
T14703 1032-1040 NN denotes staining
T14710 1040-1042 , denotes ,
T14711 1042-1044 IN denotes as
T14712 1045-1053 VBN denotes observed
T14713 1054-1056 IN denotes in
T14714 1057-1060 DT denotes the
T14716 1061-1067 JJ denotes mutant
T14715 1068-1072 NN denotes skin
T14717 1073-1074 -LRB- denotes (
T14719 1074-1080 NN denotes Figure
T14718 1081-1083 NN denotes 4Q
T14720 1083-1085 , denotes ,
T14721 1085-1087 NN denotes 4Q
T14722 1087-1088 SYM denotes ′
T14723 1088-1090 , denotes ,
T14724 1090-1093 CC denotes and
T14725 1094-1096 NN denotes 4R
T14726 1096-1097 -RRB- denotes )
T14727 1097-1098 . denotes .
T14728 1098-1251 sentence denotes Initiation of ectopic tooth buds in the mutant mice was evident at E15.5 by extra dots of Shh expression adjacent to the primary teeth (data not shown).
T14729 1099-1109 NN denotes Initiation
T14731 1110-1112 IN denotes of
T14732 1113-1120 JJ denotes ectopic
T14734 1121-1126 JJ denotes tooth
T14733 1127-1131 NNS denotes buds
T14735 1132-1134 IN denotes in
T14736 1135-1138 DT denotes the
T14738 1139-1145 JJ denotes mutant
T14737 1146-1150 NNS denotes mice
T14730 1151-1154 VBD denotes was
T14739 1155-1162 JJ denotes evident
T14740 1163-1165 IN denotes at
T14741 1166-1171 NN denotes E15.5
T14742 1172-1174 IN denotes by
T14743 1175-1180 JJ denotes extra
T14744 1181-1185 NNS denotes dots
T14745 1186-1188 IN denotes of
T14746 1189-1192 NN denotes Shh
T14747 1193-1203 NN denotes expression
T14748 1204-1212 JJ denotes adjacent
T14749 1213-1215 IN denotes to
T14750 1216-1219 DT denotes the
T14752 1220-1227 JJ denotes primary
T14751 1228-1233 NNS denotes teeth
T14753 1234-1235 -LRB- denotes (
T14755 1235-1239 NNS denotes data
T14756 1240-1243 RB denotes not
T14754 1244-1249 VBN denotes shown
T14757 1249-1250 -RRB- denotes )
T14758 1250-1251 . denotes .
R4286 T14520 T14521 advcl Similar,affected
R4287 T14522 T14520 prep to,Similar
R4288 T14523 T14524 det the,biology
R4289 T14524 T14522 pobj biology,to
R4290 T14525 T14524 prep of,biology
R4291 T14526 T14527 compound hair,follicles
R4292 T14527 T14525 pobj follicles,of
R4293 T14528 T14521 punct ", ",affected
R4294 T14529 T14530 compound K14,cre
R4295 T14530 T14532 npadvmod cre,driven
R4296 T14531 T14530 punct -,cre
R4297 T14532 T14534 amod driven,loss
R4298 T14533 T14532 punct –,driven
R4299 T14534 T14521 nsubj loss,affected
R4300 T14535 T14534 prep of,loss
R4301 T14536 T14535 pobj Apc,of
R4302 T14537 T14521 advmod also,affected
R4303 T14538 T14539 det the,development
R4304 T14539 T14521 dobj development,affected
R4305 T14540 T14539 prep of,development
R4306 T14541 T14542 amod other,appendages
R4307 T14542 T14540 pobj appendages,of
R4308 T14543 T14542 amod epidermal,appendages
R4309 T14544 T14545 dep that,depend
R4310 T14545 T14542 relcl depend,appendages
R4311 T14546 T14545 prep on,depend
R4312 T14547 T14548 amod epithelial,mesenchymal
R4313 T14548 T14550 amod mesenchymal,interactions
R4314 T14549 T14548 punct –,mesenchymal
R4315 T14550 T14546 pobj interactions,on
R4316 T14551 T14545 prep for,depend
R4317 T14552 T14553 poss their,formation
R4318 T14553 T14551 pobj formation,for
R4319 T14554 T14521 punct .,affected
R4320 T14556 T14557 det The,striking
R4321 T14557 T14559 nsubj striking,was
R4322 T14558 T14557 advmod most,striking
R4323 T14560 T14557 prep of,striking
R4324 T14561 T14560 pobj these,of
R4325 T14562 T14563 amod dental,dysplasia
R4326 T14563 T14559 attr dysplasia,was
R4327 T14564 T14565 punct (,4K
R4328 T14565 T14559 parataxis 4K,was
R4329 T14566 T14565 compound Figure,4K
R4330 T14567 T14568 punct –,4R
R4331 T14568 T14565 prep 4R,4K
R4332 T14569 T14565 punct ),4K
R4333 T14570 T14559 punct .,was
R4334 T14572 T14573 compound Tooth,development
R4335 T14573 T14574 nsubjpass development,initiated
R4336 T14575 T14574 auxpass is,initiated
R4337 T14576 T14574 advmod normally,initiated
R4338 T14577 T14574 prep between,initiated
R4339 T14578 T14577 pobj E11,between
R4340 T14579 T14578 cc and,E11
R4341 T14580 T14578 conj E12,E11
R4342 T14581 T14574 prep by,initiated
R4343 T14582 T14581 pobj invagination,by
R4344 T14583 T14582 prep of,invagination
R4345 T14584 T14585 advmod ectodermally,derived
R4346 T14585 T14586 amod derived,epithelium
R4347 T14586 T14583 pobj epithelium,of
R4348 T14587 T14586 amod oral,epithelium
R4349 T14588 T14582 prep into,invagination
R4350 T14589 T14590 det the,mesenchyme
R4351 T14590 T14588 pobj mesenchyme,into
R4352 T14591 T14590 amod underlying,mesenchyme
R4353 T14592 T14593 amod cranial,crest
R4354 T14593 T14595 npadvmod crest,derived
R4355 T14594 T14593 amod neural,crest
R4356 T14595 T14590 amod derived,mesenchyme
R4357 T14596 T14595 punct –,derived
R4358 T14597 T14574 punct ", ",initiated
R4359 T14598 T14574 advcl generating,initiated
R4360 T14599 T14600 det a,germ
R4361 T14600 T14598 dobj germ,generating
R4362 T14601 T14600 amod tooth,germ
R4363 T14602 T14574 punct .,initiated
R4364 T14604 T14605 prep Despite,revealed
R4365 T14606 T14607 det the,phenotype
R4366 T14607 T14604 pobj phenotype,Despite
R4367 T14608 T14609 advmod grossly,toothless
R4368 T14609 T14607 amod toothless,phenotype
R4369 T14610 T14607 prep of,phenotype
R4370 T14611 T14612 compound KA,mutants
R4371 T14612 T14610 pobj mutants,of
R4372 T14613 T14605 punct ", ",revealed
R4373 T14614 T14615 amod histological,analysis
R4374 T14615 T14605 nsubj analysis,revealed
R4375 T14616 T14615 prep of,analysis
R4376 T14617 T14618 poss their,cavities
R4377 T14618 T14616 pobj cavities,of
R4378 T14619 T14618 amod oral,cavities
R4379 T14620 T14621 det the,formation
R4380 T14621 T14605 dobj formation,revealed
R4381 T14622 T14621 prep of,formation
R4382 T14623 T14624 amod multiple,buds
R4383 T14624 T14622 pobj buds,of
R4384 T14625 T14624 amod tooth,buds
R4385 T14626 T14605 prep at,revealed
R4386 T14627 T14628 det each,location
R4387 T14628 T14626 pobj location,at
R4388 T14629 T14605 punct .,revealed
R4389 T14631 T14632 det These,teeth
R4390 T14632 T14634 nsubj teeth,failed
R4391 T14633 T14632 amod aberrant,teeth
R4392 T14635 T14634 advmod obviously,failed
R4393 T14636 T14637 aux to,grow
R4394 T14637 T14634 xcomp grow,failed
R4395 T14638 T14637 prt out,grow
R4396 T14639 T14637 prep during,grow
R4397 T14640 T14641 det the,transition
R4398 T14641 T14639 pobj transition,during
R4399 T14642 T14641 amod dietary,transition
R4400 T14643 T14641 prep from,transition
R4401 T14644 T14643 pobj milk,from
R4402 T14645 T14641 prep to,transition
R4403 T14646 T14647 amod solid,food
R4404 T14647 T14645 pobj food,to
R4405 T14648 T14634 punct .,failed
R4406 T14650 T14651 advcl Analogous,detected
R4407 T14652 T14650 prep to,Analogous
R4408 T14653 T14654 det the,patterns
R4409 T14654 T14652 pobj patterns,to
R4410 T14655 T14654 compound expression,patterns
R4411 T14656 T14654 prep of,patterns
R4412 T14657 T14656 pobj K14,of
R4413 T14658 T14657 cc and,K14
R4414 T14659 T14660 compound β,catenin
R4415 T14660 T14657 conj catenin,K14
R4416 T14661 T14660 punct -,catenin
R4417 T14662 T14654 prep in,patterns
R4418 T14663 T14664 det the,skin
R4419 T14664 T14662 pobj skin,in
R4420 T14665 T14664 amod normal,skin
R4421 T14666 T14651 punct ", ",detected
R4422 T14667 T14668 amod diffuse,expression
R4423 T14668 T14651 nsubjpass expression,detected
R4424 T14669 T14670 npadvmod membrane,bound
R4425 T14670 T14668 amod bound,expression
R4426 T14671 T14670 punct -,bound
R4427 T14672 T14668 prep of,expression
R4428 T14673 T14674 compound β,catenin
R4429 T14674 T14672 pobj catenin,of
R4430 T14675 T14674 punct -,catenin
R4431 T14676 T14651 auxpass was,detected
R4432 T14677 T14651 prep in,detected
R4433 T14678 T14679 npadvmod K14,expressing
R4434 T14679 T14681 amod expressing,epithelium
R4435 T14680 T14679 punct -,expressing
R4436 T14681 T14677 pobj epithelium,in
R4437 T14682 T14681 amod oral,epithelium
R4438 T14683 T14681 cc and,epithelium
R4439 T14684 T14681 conj ameloblasts,epithelium
R4440 T14685 T14681 prep of,epithelium
R4441 T14686 T14687 amod normal,mice
R4442 T14687 T14685 pobj mice,of
R4443 T14688 T14651 punct .,detected
R4444 T14690 T14691 prep In,showed
R4445 T14692 T14690 pobj mutants,In
R4446 T14693 T14691 punct ", ",showed
R4447 T14694 T14691 nsubj some,showed
R4448 T14695 T14694 prep of,some
R4449 T14696 T14697 det the,cells
R4450 T14697 T14695 pobj cells,of
R4451 T14698 T14699 npadvmod K14,expressing
R4452 T14699 T14697 amod expressing,cells
R4453 T14700 T14699 punct -,expressing
R4454 T14701 T14691 advmod also,showed
R4455 T14702 T14703 amod strong,staining
R4456 T14703 T14691 dobj staining,showed
R4457 T14704 T14705 amod cytosolic,β
R4458 T14705 T14703 nmod β,staining
R4459 T14706 T14705 punct /,β
R4460 T14707 T14705 amod nuclear,β
R4461 T14708 T14705 punct -,β
R4462 T14709 T14705 appos catenin,β
R4463 T14710 T14691 punct ", ",showed
R4464 T14711 T14712 mark as,observed
R4465 T14712 T14691 advcl observed,showed
R4466 T14713 T14712 prep in,observed
R4467 T14714 T14715 det the,skin
R4468 T14715 T14713 pobj skin,in
R4469 T14716 T14715 amod mutant,skin
R4470 T14717 T14718 punct (,4Q
R4471 T14718 T14691 parataxis 4Q,showed
R4472 T14719 T14718 compound Figure,4Q
R4473 T14720 T14718 punct ", ",4Q
R4474 T14721 T14718 conj 4Q,4Q
R4475 T14722 T14721 punct ′,4Q
R4476 T14723 T14721 punct ", ",4Q
R4477 T14724 T14721 cc and,4Q
R4478 T14725 T14721 conj 4R,4Q
R4479 T14726 T14718 punct ),4Q
R4480 T14727 T14691 punct .,showed
R4481 T14729 T14730 nsubj Initiation,was
R4482 T14731 T14729 prep of,Initiation
R4483 T14732 T14733 amod ectopic,buds
R4484 T14733 T14731 pobj buds,of
R4485 T14734 T14733 amod tooth,buds
R4486 T14735 T14729 prep in,Initiation
R4487 T14736 T14737 det the,mice
R4488 T14737 T14735 pobj mice,in
R4489 T14738 T14737 amod mutant,mice
R4490 T14739 T14730 acomp evident,was
R4491 T14740 T14730 prep at,was
R4492 T14741 T14740 pobj E15.5,at
R4493 T14742 T14730 prep by,was
R4494 T14743 T14744 amod extra,dots
R4495 T14744 T14742 pobj dots,by
R4496 T14745 T14744 prep of,dots
R4497 T14746 T14747 compound Shh,expression
R4498 T14747 T14745 pobj expression,of
R4499 T14748 T14744 amod adjacent,dots
R4500 T14749 T14748 prep to,adjacent
R4501 T14750 T14751 det the,teeth
R4502 T14751 T14749 pobj teeth,to
R4503 T14752 T14751 amod primary,teeth
R4504 T14753 T14754 punct (,shown
R4505 T14754 T14730 parataxis shown,was
R4506 T14755 T14754 nsubj data,shown
R4507 T14756 T14754 neg not,shown
R4508 T14757 T14754 punct ),shown
R4509 T14758 T14730 punct .,was