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PMC:1564426 / 2758-6560 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T2364 13-24 JJ denotes Adenomatous
T2366 25-34 NN denotes polyposis
T2365 35-39 NN denotes coli
T2368 40-41 -LRB- denotes (
T2369 41-44 NN denotes APC
T2370 44-45 -RRB- denotes )
T2367 46-48 VBZ denotes is
T2371 49-50 DT denotes a
T2372 51-57 NN denotes member
T2373 58-60 IN denotes of
T2374 61-64 DT denotes the
T2376 65-68 NN denotes Wnt
T2377 69-78 NN denotes signaling
T2375 79-86 NN denotes pathway
T2378 87-90 CC denotes and
T2379 91-94 CD denotes one
T2381 95-97 IN denotes of
T2382 98-101 PRP$ denotes its
T2384 102-107 JJ denotes known
T2383 108-117 NNS denotes functions
T2380 118-120 VBZ denotes is
T2385 121-123 TO denotes to
T2386 124-132 VB denotes regulate
T2387 133-136 DT denotes the
T2388 137-143 NNS denotes levels
T2389 144-146 IN denotes of
T2390 147-148 NN denotes β
T2392 148-149 HYPH denotes -
T2391 149-156 NN denotes catenin
T2393 156-157 . denotes .
T2394 157-230 sentence denotes Alterations in β-catenin regulation are very common in human tumors [1].
T2395 158-169 NNS denotes Alterations
T2397 170-172 IN denotes in
T2398 173-174 NN denotes β
T2400 174-175 HYPH denotes -
T2399 175-182 NN denotes catenin
T2401 183-193 NN denotes regulation
T2396 194-197 VBP denotes are
T2402 198-202 RB denotes very
T2403 203-209 JJ denotes common
T2404 210-212 IN denotes in
T2405 213-218 JJ denotes human
T2406 219-225 NNS denotes tumors
T2407 226-227 -LRB- denotes [
T2408 227-228 CD denotes 1
T2409 228-229 -RRB- denotes ]
T2410 229-230 . denotes .
T2411 230-419 sentence denotes Loss of APC is associated with stabilization of the cytosolic β-catenin that ultimately results in its migration to the nucleus and activating a cascade of events leading to tumorigenesis.
T2412 231-235 NN denotes Loss
T2414 236-238 IN denotes of
T2415 239-242 NN denotes APC
T2416 243-245 VBZ denotes is
T2413 246-256 VBN denotes associated
T2417 257-261 IN denotes with
T2418 262-275 NN denotes stabilization
T2419 276-278 IN denotes of
T2420 279-282 DT denotes the
T2422 283-292 JJ denotes cytosolic
T2423 293-294 NN denotes β
T2424 294-295 HYPH denotes -
T2421 295-302 NN denotes catenin
T2425 303-307 WDT denotes that
T2427 308-318 RB denotes ultimately
T2426 319-326 VBZ denotes results
T2428 327-329 IN denotes in
T2429 330-333 PRP$ denotes its
T2430 334-343 NN denotes migration
T2431 344-346 IN denotes to
T2432 347-350 DT denotes the
T2433 351-358 NN denotes nucleus
T2434 359-362 CC denotes and
T2435 363-373 VBG denotes activating
T2436 374-375 DT denotes a
T2437 376-383 NN denotes cascade
T2438 384-386 IN denotes of
T2439 387-393 NNS denotes events
T2440 394-401 VBG denotes leading
T2441 402-404 IN denotes to
T2442 405-418 NN denotes tumorigenesis
T2443 418-419 . denotes .
T2444 419-679 sentence denotes APC also interacts with a multitude of other cellular proteins, including axin-2 (AXIN2), plakoglobin (JUP), Asef (ARHGEF4), kinesin superfamily–associated protein 3 (KIFAP3), EB1 (MAPRE1), microtubules, and the human homolog of Drosophila discs large (DLG1).
T2445 420-423 NN denotes APC
T2447 424-428 RB denotes also
T2446 429-438 VBZ denotes interacts
T2448 439-443 IN denotes with
T2449 444-445 DT denotes a
T2450 446-455 NN denotes multitude
T2451 456-458 IN denotes of
T2452 459-464 JJ denotes other
T2454 465-473 JJ denotes cellular
T2453 474-482 NN denotes proteins
T2455 482-484 , denotes ,
T2456 484-493 VBG denotes including
T2457 494-498 NN denotes axin
T2458 498-499 HYPH denotes -
T2459 499-500 CD denotes 2
T2460 501-502 -LRB- denotes (
T2461 502-507 NN denotes AXIN2
T2462 507-508 -RRB- denotes )
T2463 508-510 , denotes ,
T2464 510-521 NN denotes plakoglobin
T2465 522-523 -LRB- denotes (
T2466 523-526 NN denotes JUP
T2467 526-527 -RRB- denotes )
T2468 527-529 , denotes ,
T2469 529-533 NN denotes Asef
T2470 534-535 -LRB- denotes (
T2471 535-542 NN denotes ARHGEF4
T2472 542-543 -RRB- denotes )
T2473 543-545 , denotes ,
T2474 545-552 NN denotes kinesin
T2475 553-564 NN denotes superfamily
T2477 564-565 HYPH denotes –
T2476 565-575 VBN denotes associated
T2478 576-583 NN denotes protein
T2479 584-585 CD denotes 3
T2480 586-587 -LRB- denotes (
T2481 587-593 NN denotes KIFAP3
T2482 593-594 -RRB- denotes )
T2483 594-596 , denotes ,
T2484 596-599 NN denotes EB1
T2485 600-601 -LRB- denotes (
T2486 601-607 NN denotes MAPRE1
T2487 607-608 -RRB- denotes )
T2488 608-610 , denotes ,
T2489 610-622 NNS denotes microtubules
T2490 622-624 , denotes ,
T2491 624-627 CC denotes and
T2492 628-631 DT denotes the
T2494 632-637 JJ denotes human
T2493 638-645 NN denotes homolog
T2495 646-648 IN denotes of
T2496 649-659 NNP denotes Drosophila
T2497 660-665 NNS denotes discs
T2498 666-671 JJ denotes large
T2499 672-673 -LRB- denotes (
T2500 673-677 NN denotes DLG1
T2501 677-678 -RRB- denotes )
T2502 678-679 . denotes .
T2503 679-990 sentence denotes These interactions suggest that APC can potentially regulate many cellular functions, including intercellular adhesion, cytoskeletal organization, regulation of plakoglobin levels, regulation of the cell cycle and apoptosis, orientation of asymmetric stem cell division, and control of cell polarization [2,3].
T2504 680-685 DT denotes These
T2505 686-698 NNS denotes interactions
T2506 699-706 VBP denotes suggest
T2507 707-711 IN denotes that
T2509 712-715 NN denotes APC
T2510 716-719 MD denotes can
T2511 720-731 RB denotes potentially
T2508 732-740 VB denotes regulate
T2512 741-745 JJ denotes many
T2514 746-754 JJ denotes cellular
T2513 755-764 NNS denotes functions
T2515 764-766 , denotes ,
T2516 766-775 VBG denotes including
T2517 776-789 JJ denotes intercellular
T2518 790-798 NN denotes adhesion
T2519 798-800 , denotes ,
T2520 800-812 JJ denotes cytoskeletal
T2521 813-825 NN denotes organization
T2522 825-827 , denotes ,
T2523 827-837 NN denotes regulation
T2524 838-840 IN denotes of
T2525 841-852 NN denotes plakoglobin
T2526 853-859 NNS denotes levels
T2527 859-861 , denotes ,
T2528 861-871 NN denotes regulation
T2529 872-874 IN denotes of
T2530 875-878 DT denotes the
T2532 879-883 NN denotes cell
T2531 884-889 NN denotes cycle
T2533 890-893 CC denotes and
T2534 894-903 NN denotes apoptosis
T2535 903-905 , denotes ,
T2536 905-916 NN denotes orientation
T2537 917-919 IN denotes of
T2538 920-930 JJ denotes asymmetric
T2540 931-935 NN denotes stem
T2541 936-940 NN denotes cell
T2539 941-949 NN denotes division
T2542 949-951 , denotes ,
T2543 951-954 CC denotes and
T2544 955-962 NN denotes control
T2545 963-965 IN denotes of
T2546 966-970 NN denotes cell
T2547 971-983 NN denotes polarization
T2548 984-985 -LRB- denotes [
T2550 985-986 CD denotes 2
T2551 986-987 , denotes ,
T2549 987-988 CD denotes 3
T2552 988-989 -RRB- denotes ]
T2553 989-990 . denotes .
T2554 990-1022 sentence denotes APC is a tumor suppressor gene.
T2555 991-994 NN denotes APC
T2556 995-997 VBZ denotes is
T2557 998-999 DT denotes a
T2559 1000-1005 NN denotes tumor
T2560 1006-1016 NN denotes suppressor
T2558 1017-1021 NN denotes gene
T2561 1021-1022 . denotes .
T2562 1022-1117 sentence denotes Somatic mutations in APC are frequently found in many sporadic tumors of the colon and rectum.
T2563 1023-1030 JJ denotes Somatic
T2564 1031-1040 NNS denotes mutations
T2566 1041-1043 IN denotes in
T2567 1044-1047 NN denotes APC
T2568 1048-1051 VBP denotes are
T2569 1052-1062 RB denotes frequently
T2565 1063-1068 VBN denotes found
T2570 1069-1071 IN denotes in
T2571 1072-1076 JJ denotes many
T2573 1077-1085 JJ denotes sporadic
T2572 1086-1092 NNS denotes tumors
T2574 1093-1095 IN denotes of
T2575 1096-1099 DT denotes the
T2576 1100-1105 NN denotes colon
T2577 1106-1109 CC denotes and
T2578 1110-1116 NN denotes rectum
T2579 1116-1117 . denotes .
T2580 1117-1239 sentence denotes Autosomal dominant germline mutations in APC cause familial adenomatous polypois (FAP) and its variant, Gardner syndrome.
T2581 1118-1127 JJ denotes Autosomal
T2583 1128-1136 JJ denotes dominant
T2584 1137-1145 NN denotes germline
T2582 1146-1155 NNS denotes mutations
T2586 1156-1158 IN denotes in
T2587 1159-1162 NN denotes APC
T2585 1163-1168 VBP denotes cause
T2588 1169-1177 JJ denotes familial
T2590 1178-1189 JJ denotes adenomatous
T2589 1190-1198 NN denotes polypois
T2591 1199-1200 -LRB- denotes (
T2592 1200-1203 NN denotes FAP
T2593 1203-1204 -RRB- denotes )
T2594 1205-1208 CC denotes and
T2595 1209-1212 PRP$ denotes its
T2596 1213-1220 NN denotes variant
T2597 1220-1222 , denotes ,
T2598 1222-1229 NNP denotes Gardner
T2599 1230-1238 NN denotes syndrome
T2600 1238-1239 . denotes .
T2601 1239-1422 sentence denotes FAP patients are characterized by hundreds of adenomatous colorectal polyps, with an almost inevitable progression to colorectal cancer in the third and fourth decades of life [4,5].
T2602 1240-1243 NN denotes FAP
T2603 1244-1252 NNS denotes patients
T2605 1253-1256 VBP denotes are
T2604 1257-1270 VBN denotes characterized
T2606 1271-1273 IN denotes by
T2607 1274-1282 NNS denotes hundreds
T2608 1283-1285 IN denotes of
T2609 1286-1297 JJ denotes adenomatous
T2611 1298-1308 JJ denotes colorectal
T2610 1309-1315 NNS denotes polyps
T2612 1315-1317 , denotes ,
T2613 1317-1321 IN denotes with
T2614 1322-1324 DT denotes an
T2616 1325-1331 RB denotes almost
T2617 1332-1342 JJ denotes inevitable
T2615 1343-1354 NN denotes progression
T2618 1355-1357 IN denotes to
T2619 1358-1368 JJ denotes colorectal
T2620 1369-1375 NN denotes cancer
T2621 1376-1378 IN denotes in
T2622 1379-1382 DT denotes the
T2624 1383-1388 JJ denotes third
T2625 1389-1392 CC denotes and
T2626 1393-1399 JJ denotes fourth
T2623 1400-1407 NNS denotes decades
T2627 1408-1410 IN denotes of
T2628 1411-1415 NN denotes life
T2629 1416-1417 -LRB- denotes [
T2631 1417-1418 CD denotes 4
T2632 1418-1419 , denotes ,
T2630 1419-1420 CD denotes 5
T2633 1420-1421 -RRB- denotes ]
T2634 1421-1422 . denotes .
T2635 1422-1787 sentence denotes In addition to colorectal neoplams, these individuals can develop extracolonic symptoms, among which are upper gastrointestinal tract polyps, congenital hypertrophy of the retinal pigment epithelium, desmoid tumors, disorders of the maxillary and skeletal bones, and dental abnormalities [6], suggesting the importance of APC gene functions in these organ systems.
T2636 1423-1425 IN denotes In
T2638 1426-1434 NN denotes addition
T2639 1435-1437 IN denotes to
T2640 1438-1448 JJ denotes colorectal
T2641 1449-1457 NNS denotes neoplams
T2642 1457-1459 , denotes ,
T2643 1459-1464 DT denotes these
T2644 1465-1476 NNS denotes individuals
T2645 1477-1480 MD denotes can
T2637 1481-1488 VB denotes develop
T2646 1489-1501 JJ denotes extracolonic
T2647 1502-1510 NNS denotes symptoms
T2648 1510-1512 , denotes ,
T2649 1512-1517 IN denotes among
T2651 1518-1523 WDT denotes which
T2650 1524-1527 VBP denotes are
T2652 1528-1533 JJ denotes upper
T2654 1534-1550 JJ denotes gastrointestinal
T2653 1551-1556 NN denotes tract
T2655 1557-1563 NNS denotes polyps
T2656 1563-1565 , denotes ,
T2657 1565-1575 JJ denotes congenital
T2658 1576-1587 NN denotes hypertrophy
T2659 1588-1590 IN denotes of
T2660 1591-1594 DT denotes the
T2662 1595-1602 JJ denotes retinal
T2663 1603-1610 NN denotes pigment
T2661 1611-1621 NN denotes epithelium
T2664 1621-1623 , denotes ,
T2665 1623-1630 JJ denotes desmoid
T2666 1631-1637 NNS denotes tumors
T2667 1637-1639 , denotes ,
T2668 1639-1648 NNS denotes disorders
T2669 1649-1651 IN denotes of
T2670 1652-1655 DT denotes the
T2672 1656-1665 JJ denotes maxillary
T2673 1666-1669 CC denotes and
T2674 1670-1678 JJ denotes skeletal
T2671 1679-1684 NNS denotes bones
T2675 1684-1686 , denotes ,
T2676 1686-1689 CC denotes and
T2677 1690-1696 JJ denotes dental
T2678 1697-1710 NNS denotes abnormalities
T2679 1711-1712 -LRB- denotes [
T2680 1712-1713 CD denotes 6
T2681 1713-1714 -RRB- denotes ]
T2682 1714-1716 , denotes ,
T2683 1716-1726 VBG denotes suggesting
T2684 1727-1730 DT denotes the
T2685 1731-1741 NN denotes importance
T2686 1742-1744 IN denotes of
T2687 1745-1748 NN denotes APC
T2688 1749-1753 NN denotes gene
T2689 1754-1763 VBZ denotes functions
T2690 1764-1766 IN denotes in
T2691 1767-1772 DT denotes these
T2693 1773-1778 NN denotes organ
T2692 1779-1786 NNS denotes systems
T2694 1786-1787 . denotes .
T2695 1787-1956 sentence denotes Although the role of APC in the initiation of human colorectal cancer is well established, its role in other tissue and developmental processes are not well understood.
T2696 1788-1796 IN denotes Although
T2698 1797-1800 DT denotes the
T2699 1801-1805 NN denotes role
T2700 1806-1808 IN denotes of
T2701 1809-1812 NN denotes APC
T2702 1813-1815 IN denotes in
T2703 1816-1819 DT denotes the
T2704 1820-1830 NN denotes initiation
T2705 1831-1833 IN denotes of
T2706 1834-1839 JJ denotes human
T2708 1840-1850 JJ denotes colorectal
T2707 1851-1857 NN denotes cancer
T2697 1858-1860 VBZ denotes is
T2710 1861-1865 RB denotes well
T2711 1866-1877 JJ denotes established
T2712 1877-1879 , denotes ,
T2713 1879-1882 PRP$ denotes its
T2714 1883-1887 NN denotes role
T2715 1888-1890 IN denotes in
T2716 1891-1896 JJ denotes other
T2718 1897-1903 NN denotes tissue
T2719 1904-1907 CC denotes and
T2720 1908-1921 JJ denotes developmental
T2717 1922-1931 NNS denotes processes
T2721 1932-1935 VBP denotes are
T2722 1936-1939 RB denotes not
T2723 1940-1944 RB denotes well
T2709 1945-1955 VBN denotes understood
T2724 1955-1956 . denotes .
T2725 1956-2219 sentence denotes Given the importance of regulation of Wnt signaling in embryonic pattern formation and morphogenesis of many organs, mechanistic understanding of APC in development and in extracolonic tissues becomes critical to better assess potential adverse events in humans.
T2726 1957-1962 VBN denotes Given
T2728 1963-1966 DT denotes the
T2729 1967-1977 NN denotes importance
T2730 1978-1980 IN denotes of
T2731 1981-1991 NN denotes regulation
T2732 1992-1994 IN denotes of
T2733 1995-1998 NN denotes Wnt
T2734 1999-2008 NN denotes signaling
T2735 2009-2011 IN denotes in
T2736 2012-2021 JJ denotes embryonic
T2738 2022-2029 NN denotes pattern
T2737 2030-2039 NN denotes formation
T2739 2040-2043 CC denotes and
T2740 2044-2057 NN denotes morphogenesis
T2741 2058-2060 IN denotes of
T2742 2061-2065 JJ denotes many
T2743 2066-2072 NNS denotes organs
T2744 2072-2074 , denotes ,
T2745 2074-2085 JJ denotes mechanistic
T2746 2086-2099 NN denotes understanding
T2747 2100-2102 IN denotes of
T2748 2103-2106 NN denotes APC
T2749 2107-2109 IN denotes in
T2750 2110-2121 NN denotes development
T2751 2122-2125 CC denotes and
T2752 2126-2128 IN denotes in
T2753 2129-2141 JJ denotes extracolonic
T2754 2142-2149 NNS denotes tissues
T2727 2150-2157 VBZ denotes becomes
T2755 2158-2166 JJ denotes critical
T2756 2167-2169 TO denotes to
T2758 2170-2176 RBR denotes better
T2757 2177-2183 VB denotes assess
T2759 2184-2193 JJ denotes potential
T2761 2194-2201 JJ denotes adverse
T2760 2202-2208 NNS denotes events
T2762 2209-2211 IN denotes in
T2763 2212-2218 NNS denotes humans
T2764 2218-2219 . denotes .
T2765 2219-2331 sentence denotes One approach to understand the role of Apc in development is to develop mice with an inactivating Apc mutation.
T2766 2220-2223 CD denotes One
T2767 2224-2232 NN denotes approach
T2769 2233-2235 TO denotes to
T2770 2236-2246 VB denotes understand
T2771 2247-2250 DT denotes the
T2772 2251-2255 NN denotes role
T2773 2256-2258 IN denotes of
T2774 2259-2262 NN denotes Apc
T2775 2263-2265 IN denotes in
T2776 2266-2277 NN denotes development
T2768 2278-2280 VBZ denotes is
T2777 2281-2283 TO denotes to
T2778 2284-2291 VB denotes develop
T2779 2292-2296 NNS denotes mice
T2780 2297-2301 IN denotes with
T2781 2302-2304 DT denotes an
T2783 2305-2317 VBG denotes inactivating
T2784 2318-2321 NN denotes Apc
T2782 2322-2330 NN denotes mutation
T2785 2330-2331 . denotes .
T2786 2331-2410 sentence denotes Several genetically modified mouse strains for Apc have been described [7–10].
T2787 2332-2339 JJ denotes Several
T2789 2340-2351 RB denotes genetically
T2790 2352-2360 VBN denotes modified
T2791 2361-2366 NN denotes mouse
T2788 2367-2374 NNS denotes strains
T2793 2375-2378 IN denotes for
T2794 2379-2382 NN denotes Apc
T2795 2383-2387 VBP denotes have
T2796 2388-2392 VBN denotes been
T2792 2393-2402 VBN denotes described
T2797 2403-2404 -LRB- denotes [
T2798 2404-2405 CD denotes 7
T2799 2405-2406 SYM denotes –
T2800 2406-2408 CD denotes 10
T2801 2408-2409 -RRB- denotes ]
T2802 2409-2410 . denotes .
T2803 2410-2532 sentence denotes Most of these models, in the heterozygous state, show a gastrointestinal and other tumor predisposition phenotype [7–10].
T2804 2411-2415 JJS denotes Most
T2806 2416-2418 IN denotes of
T2807 2419-2424 DT denotes these
T2808 2425-2431 NNS denotes models
T2809 2431-2433 , denotes ,
T2810 2433-2435 IN denotes in
T2811 2436-2439 DT denotes the
T2813 2440-2452 JJ denotes heterozygous
T2812 2453-2458 NN denotes state
T2814 2458-2460 , denotes ,
T2805 2460-2464 VBP denotes show
T2815 2465-2466 DT denotes a
T2817 2467-2483 JJ denotes gastrointestinal
T2819 2484-2487 CC denotes and
T2820 2488-2493 JJ denotes other
T2818 2494-2499 NN denotes tumor
T2821 2500-2514 NN denotes predisposition
T2816 2515-2524 NN denotes phenotype
T2822 2525-2526 -LRB- denotes [
T2823 2526-2527 CD denotes 7
T2824 2527-2528 SYM denotes –
T2825 2528-2530 CD denotes 10
T2826 2530-2531 -RRB- denotes ]
T2827 2531-2532 . denotes .
T2828 2532-2687 sentence denotes Mouse embryos that are homozygous for the genetic modification die during embryogenesis, and some of the models do not survive beyond gastrulation [8,11].
T2829 2533-2538 NN denotes Mouse
T2830 2539-2546 NNS denotes embryos
T2832 2547-2551 WDT denotes that
T2833 2552-2555 VBP denotes are
T2834 2556-2566 JJ denotes homozygous
T2835 2567-2570 IN denotes for
T2836 2571-2574 DT denotes the
T2838 2575-2582 JJ denotes genetic
T2837 2583-2595 NN denotes modification
T2831 2596-2599 VBP denotes die
T2839 2600-2606 IN denotes during
T2840 2607-2620 NN denotes embryogenesis
T2841 2620-2622 , denotes ,
T2842 2622-2625 CC denotes and
T2843 2626-2630 DT denotes some
T2845 2631-2633 IN denotes of
T2846 2634-2637 DT denotes the
T2847 2638-2644 NNS denotes models
T2848 2645-2647 VBP denotes do
T2849 2648-2651 RB denotes not
T2844 2652-2659 VB denotes survive
T2850 2660-2666 IN denotes beyond
T2851 2667-2679 NN denotes gastrulation
T2852 2680-2681 -LRB- denotes [
T2854 2681-2682 CD denotes 8
T2855 2682-2683 , denotes ,
T2853 2683-2685 CD denotes 11
T2856 2685-2686 -RRB- denotes ]
T2857 2686-2687 . denotes .
T2858 2687-2975 sentence denotes An alternate approach to understand the role of Apc in development and/or in specific tissues is to generate a mouse strain that carries a conditionally modified allele and mate it with a mouse strain that facilitates the modification of the conditional allele in specific cell lineages.
T2859 2688-2690 DT denotes An
T2861 2691-2700 JJ denotes alternate
T2860 2701-2709 NN denotes approach
T2863 2710-2712 TO denotes to
T2864 2713-2723 VB denotes understand
T2865 2724-2727 DT denotes the
T2866 2728-2732 NN denotes role
T2867 2733-2735 IN denotes of
T2868 2736-2739 NN denotes Apc
T2869 2740-2742 IN denotes in
T2870 2743-2754 NN denotes development
T2871 2755-2758 CC denotes and
T2872 2758-2759 HYPH denotes /
T2873 2759-2761 CC denotes or
T2874 2762-2764 IN denotes in
T2875 2765-2773 JJ denotes specific
T2876 2774-2781 NNS denotes tissues
T2862 2782-2784 VBZ denotes is
T2877 2785-2787 TO denotes to
T2878 2788-2796 VB denotes generate
T2879 2797-2798 DT denotes a
T2881 2799-2804 NN denotes mouse
T2880 2805-2811 NN denotes strain
T2882 2812-2816 WDT denotes that
T2883 2817-2824 VBZ denotes carries
T2884 2825-2826 DT denotes a
T2886 2827-2840 RB denotes conditionally
T2887 2841-2849 VBN denotes modified
T2885 2850-2856 NN denotes allele
T2888 2857-2860 CC denotes and
T2889 2861-2865 VB denotes mate
T2890 2866-2868 PRP denotes it
T2891 2869-2873 IN denotes with
T2892 2874-2875 DT denotes a
T2894 2876-2881 NN denotes mouse
T2893 2882-2888 NN denotes strain
T2895 2889-2893 WDT denotes that
T2896 2894-2905 VBZ denotes facilitates
T2897 2906-2909 DT denotes the
T2898 2910-2922 NN denotes modification
T2899 2923-2925 IN denotes of
T2900 2926-2929 DT denotes the
T2902 2930-2941 JJ denotes conditional
T2901 2942-2948 NN denotes allele
T2903 2949-2951 IN denotes in
T2904 2952-2960 JJ denotes specific
T2906 2961-2965 NN denotes cell
T2905 2966-2974 NNS denotes lineages
T2907 2974-2975 . denotes .
T2908 2975-3134 sentence denotes To assess the role of Apc in different stages of life systematically, we generated mice containing a conditional knockout (CKO) mutant allele of Apc (ApcCKO).
T2909 2976-2978 TO denotes To
T2910 2979-2985 VB denotes assess
T2912 2986-2989 DT denotes the
T2913 2990-2994 NN denotes role
T2914 2995-2997 IN denotes of
T2915 2998-3001 NN denotes Apc
T2916 3002-3004 IN denotes in
T2917 3005-3014 JJ denotes different
T2918 3015-3021 NNS denotes stages
T2919 3022-3024 IN denotes of
T2920 3025-3029 NN denotes life
T2921 3030-3044 RB denotes systematically
T2922 3044-3046 , denotes ,
T2923 3046-3048 PRP denotes we
T2911 3049-3058 VBD denotes generated
T2924 3059-3063 NNS denotes mice
T2925 3064-3074 VBG denotes containing
T2926 3075-3076 DT denotes a
T2928 3077-3088 JJ denotes conditional
T2929 3089-3097 NN denotes knockout
T2930 3098-3099 -LRB- denotes (
T2931 3099-3102 NN denotes CKO
T2932 3102-3103 -RRB- denotes )
T2933 3104-3110 JJ denotes mutant
T2927 3111-3117 NN denotes allele
T2934 3118-3120 IN denotes of
T2935 3121-3124 NN denotes Apc
T2936 3125-3126 -LRB- denotes (
T2937 3126-3132 NN denotes ApcCKO
T2938 3132-3133 -RRB- denotes )
T2939 3133-3134 . denotes .
T2940 3134-3329 sentence denotes These mice were mated with a strain carrying Cre recombinase under the control of the human Keratin 14 (K14) promoter, which is active in basal cells of epidermis and other stratified epithelia.
T2941 3135-3140 DT denotes These
T2942 3141-3145 NNS denotes mice
T2944 3146-3150 VBD denotes were
T2943 3151-3156 VBN denotes mated
T2945 3157-3161 IN denotes with
T2946 3162-3163 DT denotes a
T2947 3164-3170 NN denotes strain
T2948 3171-3179 VBG denotes carrying
T2949 3180-3183 NN denotes Cre
T2950 3184-3195 NN denotes recombinase
T2951 3196-3201 IN denotes under
T2952 3202-3205 DT denotes the
T2953 3206-3213 NN denotes control
T2954 3214-3216 IN denotes of
T2955 3217-3220 DT denotes the
T2957 3221-3226 JJ denotes human
T2958 3227-3234 NN denotes Keratin
T2959 3235-3237 CD denotes 14
T2960 3238-3239 -LRB- denotes (
T2961 3239-3242 NN denotes K14
T2962 3242-3243 -RRB- denotes )
T2956 3244-3252 NN denotes promoter
T2963 3252-3254 , denotes ,
T2964 3254-3259 WDT denotes which
T2965 3260-3262 VBZ denotes is
T2966 3263-3269 JJ denotes active
T2967 3270-3272 IN denotes in
T2968 3273-3278 JJ denotes basal
T2969 3279-3284 NNS denotes cells
T2970 3285-3287 IN denotes of
T2971 3288-3297 NN denotes epidermis
T2972 3298-3301 CC denotes and
T2973 3302-3307 JJ denotes other
T2975 3308-3318 JJ denotes stratified
T2974 3319-3328 NNS denotes epithelia
T2976 3328-3329 . denotes .
T2977 3329-3576 sentence denotes We report here that K14 promoter-driven loss of Apc resulted in aberrant development of several organs that require inductive epithelial–mesenchymal interactions, including hair follicle, teeth, and thymus, and resulted in neonatal death in mice.
T2978 3330-3332 PRP denotes We
T2979 3333-3339 VBP denotes report
T2980 3340-3344 RB denotes here
T2981 3345-3349 IN denotes that
T2983 3350-3353 NN denotes K14
T2984 3354-3362 NN denotes promoter
T2986 3362-3363 HYPH denotes -
T2985 3363-3369 VBN denotes driven
T2987 3370-3374 NN denotes loss
T2988 3375-3377 IN denotes of
T2989 3378-3381 NN denotes Apc
T2982 3382-3390 VBD denotes resulted
T2990 3391-3393 IN denotes in
T2991 3394-3402 JJ denotes aberrant
T2992 3403-3414 NN denotes development
T2993 3415-3417 IN denotes of
T2994 3418-3425 JJ denotes several
T2995 3426-3432 NNS denotes organs
T2996 3433-3437 WDT denotes that
T2997 3438-3445 VBP denotes require
T2998 3446-3455 JJ denotes inductive
T3000 3456-3466 JJ denotes epithelial
T3002 3466-3467 HYPH denotes –
T3001 3467-3478 JJ denotes mesenchymal
T2999 3479-3491 NNS denotes interactions
T3003 3491-3493 , denotes ,
T3004 3493-3502 VBG denotes including
T3005 3503-3507 NN denotes hair
T3006 3508-3516 NN denotes follicle
T3007 3516-3518 , denotes ,
T3008 3518-3523 NNS denotes teeth
T3009 3523-3525 , denotes ,
T3010 3525-3528 CC denotes and
T3011 3529-3535 NN denotes thymus
T3012 3535-3537 , denotes ,
T3013 3537-3540 CC denotes and
T3014 3541-3549 VBD denotes resulted
T3015 3550-3552 IN denotes in
T3016 3553-3561 JJ denotes neonatal
T3017 3562-3567 NN denotes death
T3018 3568-3570 IN denotes in
T3019 3571-3575 NNS denotes mice
T3020 3575-3576 . denotes .
T3021 3576-3802 sentence denotes We found that Apc plays a crucial role in determinations of cell fates during the embryonic development, possibly via temporal and tissue-specific regulation of β-catenin levels in the skin, its appendages, and in the thymus.
T3022 3577-3579 PRP denotes We
T3023 3580-3585 VBD denotes found
T3024 3586-3590 IN denotes that
T3026 3591-3594 NN denotes Apc
T3025 3595-3600 VBZ denotes plays
T3027 3601-3602 DT denotes a
T3029 3603-3610 JJ denotes crucial
T3028 3611-3615 NN denotes role
T3030 3616-3618 IN denotes in
T3031 3619-3633 NNS denotes determinations
T3032 3634-3636 IN denotes of
T3033 3637-3641 NN denotes cell
T3034 3642-3647 NNS denotes fates
T3035 3648-3654 IN denotes during
T3036 3655-3658 DT denotes the
T3038 3659-3668 JJ denotes embryonic
T3037 3669-3680 NN denotes development
T3039 3680-3682 , denotes ,
T3040 3682-3690 RB denotes possibly
T3041 3691-3694 IN denotes via
T3042 3695-3703 JJ denotes temporal
T3044 3704-3707 CC denotes and
T3045 3708-3714 NN denotes tissue
T3047 3714-3715 HYPH denotes -
T3046 3715-3723 JJ denotes specific
T3043 3724-3734 NN denotes regulation
T3048 3735-3737 IN denotes of
T3049 3738-3739 NN denotes β
T3051 3739-3740 HYPH denotes -
T3050 3740-3747 NN denotes catenin
T3052 3748-3754 NNS denotes levels
T3053 3755-3757 IN denotes in
T3054 3758-3761 DT denotes the
T3055 3762-3766 NN denotes skin
T3056 3766-3768 , denotes ,
T3057 3768-3771 PRP$ denotes its
T3058 3772-3782 NNS denotes appendages
T3059 3782-3784 , denotes ,
T3060 3784-3787 CC denotes and
T3061 3788-3790 IN denotes in
T3062 3791-3794 DT denotes the
T3063 3795-3801 NN denotes thymus
T3064 3801-3802 . denotes .
R247 T2364 T2365 amod Adenomatous,coli
R248 T2365 T2367 nsubj coli,is
R249 T2366 T2365 compound polyposis,coli
R250 T2368 T2365 punct (,coli
R251 T2369 T2365 appos APC,coli
R252 T2370 T2367 punct ),is
R253 T2371 T2372 det a,member
R254 T2372 T2367 attr member,is
R255 T2373 T2372 prep of,member
R256 T2374 T2375 det the,pathway
R257 T2375 T2373 pobj pathway,of
R258 T2376 T2375 compound Wnt,pathway
R259 T2377 T2375 compound signaling,pathway
R260 T2378 T2367 cc and,is
R261 T2379 T2380 nsubj one,is
R262 T2380 T2367 conj is,is
R263 T2381 T2379 prep of,one
R264 T2382 T2383 poss its,functions
R265 T2383 T2381 pobj functions,of
R266 T2384 T2383 amod known,functions
R267 T2385 T2386 aux to,regulate
R268 T2386 T2380 xcomp regulate,is
R269 T2387 T2388 det the,levels
R270 T2388 T2386 dobj levels,regulate
R271 T2389 T2388 prep of,levels
R272 T2390 T2391 compound β,catenin
R273 T2391 T2389 pobj catenin,of
R274 T2392 T2391 punct -,catenin
R275 T2393 T2380 punct .,is
R276 T2395 T2396 nsubj Alterations,are
R277 T2397 T2395 prep in,Alterations
R278 T2398 T2399 compound β,catenin
R279 T2399 T2401 compound catenin,regulation
R280 T2400 T2399 punct -,catenin
R281 T2401 T2397 pobj regulation,in
R282 T2402 T2403 advmod very,common
R283 T2403 T2396 acomp common,are
R284 T2404 T2396 prep in,are
R285 T2405 T2406 amod human,tumors
R286 T2406 T2404 pobj tumors,in
R287 T2407 T2408 punct [,1
R288 T2408 T2396 parataxis 1,are
R289 T2409 T2408 punct ],1
R290 T2410 T2396 punct .,are
R291 T2412 T2413 nsubjpass Loss,associated
R292 T2414 T2412 prep of,Loss
R293 T2415 T2414 pobj APC,of
R294 T2416 T2413 auxpass is,associated
R295 T2417 T2413 prep with,associated
R296 T2418 T2417 pobj stabilization,with
R297 T2419 T2418 prep of,stabilization
R298 T2420 T2421 det the,catenin
R299 T2421 T2419 pobj catenin,of
R300 T2422 T2421 amod cytosolic,catenin
R301 T2423 T2421 compound β,catenin
R302 T2424 T2421 punct -,catenin
R303 T2425 T2426 dep that,results
R304 T2426 T2421 relcl results,catenin
R305 T2427 T2426 advmod ultimately,results
R306 T2428 T2426 prep in,results
R307 T2429 T2430 poss its,migration
R308 T2430 T2428 pobj migration,in
R309 T2431 T2430 prep to,migration
R310 T2432 T2433 det the,nucleus
R311 T2433 T2431 pobj nucleus,to
R312 T2434 T2430 cc and,migration
R313 T2435 T2430 conj activating,migration
R314 T2436 T2437 det a,cascade
R315 T2437 T2435 dobj cascade,activating
R316 T2438 T2437 prep of,cascade
R317 T2439 T2438 pobj events,of
R318 T2440 T2437 acl leading,cascade
R319 T2441 T2440 prep to,leading
R320 T2442 T2441 pobj tumorigenesis,to
R321 T2443 T2413 punct .,associated
R322 T2445 T2446 nsubj APC,interacts
R323 T2447 T2446 advmod also,interacts
R324 T2448 T2446 prep with,interacts
R325 T2449 T2450 det a,multitude
R326 T2450 T2448 pobj multitude,with
R327 T2451 T2450 prep of,multitude
R328 T2452 T2453 amod other,proteins
R329 T2453 T2451 pobj proteins,of
R330 T2454 T2453 amod cellular,proteins
R331 T2455 T2453 punct ", ",proteins
R332 T2456 T2453 prep including,proteins
R333 T2457 T2456 pobj axin,including
R334 T2458 T2457 punct -,axin
R335 T2459 T2457 nummod 2,axin
R336 T2460 T2457 punct (,axin
R337 T2461 T2457 appos AXIN2,axin
R338 T2462 T2457 punct ),axin
R339 T2463 T2457 punct ", ",axin
R340 T2464 T2457 conj plakoglobin,axin
R341 T2465 T2464 punct (,plakoglobin
R342 T2466 T2464 appos JUP,plakoglobin
R343 T2467 T2464 punct ),plakoglobin
R344 T2468 T2464 punct ", ",plakoglobin
R345 T2469 T2464 conj Asef,plakoglobin
R346 T2470 T2469 punct (,Asef
R347 T2471 T2469 appos ARHGEF4,Asef
R348 T2472 T2469 punct ),Asef
R349 T2473 T2469 punct ", ",Asef
R350 T2474 T2475 compound kinesin,superfamily
R351 T2475 T2476 npadvmod superfamily,associated
R352 T2476 T2478 amod associated,protein
R353 T2477 T2476 punct –,associated
R354 T2478 T2469 conj protein,Asef
R355 T2479 T2478 nummod 3,protein
R356 T2480 T2478 punct (,protein
R357 T2481 T2478 appos KIFAP3,protein
R358 T2482 T2478 punct ),protein
R359 T2483 T2478 punct ", ",protein
R360 T2484 T2478 conj EB1,protein
R361 T2485 T2484 punct (,EB1
R362 T2486 T2484 appos MAPRE1,EB1
R363 T2487 T2484 punct ),EB1
R364 T2488 T2484 punct ", ",EB1
R365 T2489 T2484 conj microtubules,EB1
R366 T2490 T2489 punct ", ",microtubules
R367 T2491 T2489 cc and,microtubules
R368 T2492 T2493 det the,homolog
R369 T2493 T2489 conj homolog,microtubules
R370 T2494 T2493 amod human,homolog
R371 T2495 T2493 prep of,homolog
R372 T2496 T2497 compound Drosophila,discs
R373 T2497 T2495 pobj discs,of
R374 T2498 T2497 amod large,discs
R375 T2499 T2493 punct (,homolog
R376 T2500 T2493 appos DLG1,homolog
R377 T2501 T2446 punct ),interacts
R378 T2502 T2446 punct .,interacts
R379 T2504 T2505 det These,interactions
R380 T2505 T2506 nsubj interactions,suggest
R381 T2507 T2508 mark that,regulate
R382 T2508 T2506 ccomp regulate,suggest
R383 T2509 T2508 nsubj APC,regulate
R384 T2510 T2508 aux can,regulate
R385 T2511 T2508 advmod potentially,regulate
R386 T2512 T2513 amod many,functions
R387 T2513 T2508 dobj functions,regulate
R388 T2514 T2513 amod cellular,functions
R389 T2515 T2513 punct ", ",functions
R390 T2516 T2513 prep including,functions
R391 T2517 T2518 amod intercellular,adhesion
R392 T2518 T2516 pobj adhesion,including
R393 T2519 T2518 punct ", ",adhesion
R394 T2520 T2521 amod cytoskeletal,organization
R395 T2521 T2518 conj organization,adhesion
R396 T2522 T2521 punct ", ",organization
R397 T2523 T2521 conj regulation,organization
R398 T2524 T2523 prep of,regulation
R399 T2525 T2526 compound plakoglobin,levels
R400 T2526 T2524 pobj levels,of
R401 T2527 T2523 punct ", ",regulation
R402 T2528 T2523 conj regulation,regulation
R403 T2529 T2528 prep of,regulation
R404 T2530 T2531 det the,cycle
R405 T2531 T2529 pobj cycle,of
R406 T2532 T2531 compound cell,cycle
R407 T2533 T2531 cc and,cycle
R408 T2534 T2531 conj apoptosis,cycle
R409 T2535 T2528 punct ", ",regulation
R410 T2536 T2528 conj orientation,regulation
R411 T2537 T2536 prep of,orientation
R412 T2538 T2539 amod asymmetric,division
R413 T2539 T2537 pobj division,of
R414 T2540 T2541 compound stem,cell
R415 T2541 T2539 compound cell,division
R416 T2542 T2536 punct ", ",orientation
R417 T2543 T2536 cc and,orientation
R418 T2544 T2536 conj control,orientation
R419 T2545 T2544 prep of,control
R420 T2546 T2547 compound cell,polarization
R421 T2547 T2545 pobj polarization,of
R422 T2548 T2549 punct [,3
R423 T2549 T2506 parataxis 3,suggest
R424 T2550 T2549 nummod 2,3
R425 T2551 T2549 punct ",",3
R426 T2552 T2549 punct ],3
R427 T2553 T2506 punct .,suggest
R428 T2555 T2556 nsubj APC,is
R429 T2557 T2558 det a,gene
R430 T2558 T2556 attr gene,is
R431 T2559 T2560 compound tumor,suppressor
R432 T2560 T2558 compound suppressor,gene
R433 T2561 T2556 punct .,is
R434 T2563 T2564 amod Somatic,mutations
R435 T2605 T2604 auxpass are,characterized
R436 T2564 T2565 nsubjpass mutations,found
R437 T2606 T2604 agent by,characterized
R438 T2607 T2606 pobj hundreds,by
R439 T2566 T2564 prep in,mutations
R440 T2608 T2607 prep of,hundreds
R441 T2609 T2610 amod adenomatous,polyps
R442 T2610 T2608 pobj polyps,of
R443 T2611 T2610 amod colorectal,polyps
R444 T2612 T2610 punct ", ",polyps
R445 T2613 T2610 prep with,polyps
R446 T2567 T2566 pobj APC,in
R447 T2614 T2615 det an,progression
R448 T2615 T2613 pobj progression,with
R449 T2616 T2617 advmod almost,inevitable
R450 T2617 T2615 amod inevitable,progression
R451 T2568 T2565 auxpass are,found
R452 T2618 T2615 prep to,progression
R453 T2619 T2620 amod colorectal,cancer
R454 T2620 T2618 pobj cancer,to
R455 T2569 T2565 advmod frequently,found
R456 T2621 T2615 prep in,progression
R457 T2622 T2623 det the,decades
R458 T2623 T2621 pobj decades,in
R459 T2570 T2565 prep in,found
R460 T2624 T2623 amod third,decades
R461 T2625 T2624 cc and,third
R462 T2626 T2624 conj fourth,third
R463 T2571 T2572 amod many,tumors
R464 T2627 T2623 prep of,decades
R465 T2628 T2627 pobj life,of
R466 T2629 T2630 punct [,5
R467 T2630 T2604 parataxis 5,characterized
R468 T2572 T2570 pobj tumors,in
R469 T2631 T2630 nummod 4,5
R470 T2632 T2630 punct ",",5
R471 T2633 T2630 punct ],5
R472 T2573 T2572 amod sporadic,tumors
R473 T2634 T2604 punct .,characterized
R474 T2574 T2572 prep of,tumors
R475 T2636 T2637 prep In,develop
R476 T2575 T2576 det the,colon
R477 T2638 T2636 pobj addition,In
R478 T2639 T2638 prep to,addition
R479 T2640 T2641 amod colorectal,neoplams
R480 T2641 T2639 pobj neoplams,to
R481 T2576 T2574 pobj colon,of
R482 T2642 T2637 punct ", ",develop
R483 T2643 T2644 det these,individuals
R484 T2644 T2637 nsubj individuals,develop
R485 T2577 T2576 cc and,colon
R486 T2645 T2637 aux can,develop
R487 T2646 T2647 amod extracolonic,symptoms
R488 T2647 T2637 dobj symptoms,develop
R489 T2648 T2647 punct ", ",symptoms
R490 T2578 T2576 conj rectum,colon
R491 T2649 T2650 prep among,are
R492 T2650 T2647 relcl are,symptoms
R493 T2579 T2565 punct .,found
R494 T2651 T2649 pobj which,among
R495 T2652 T2653 amod upper,tract
R496 T2653 T2655 compound tract,polyps
R497 T2654 T2653 amod gastrointestinal,tract
R498 T2655 T2650 nsubj polyps,are
R499 T2656 T2655 punct ", ",polyps
R500 T2657 T2658 amod congenital,hypertrophy
R501 T2581 T2582 amod Autosomal,mutations
R502 T2658 T2655 conj hypertrophy,polyps
R503 T2659 T2658 prep of,hypertrophy
R504 T2660 T2661 det the,epithelium
R505 T2661 T2659 pobj epithelium,of
R506 T2582 T2585 nsubj mutations,cause
R507 T2662 T2663 amod retinal,pigment
R508 T2663 T2661 compound pigment,epithelium
R509 T2664 T2658 punct ", ",hypertrophy
R510 T2583 T2582 amod dominant,mutations
R511 T2665 T2666 amod desmoid,tumors
R512 T2666 T2658 conj tumors,hypertrophy
R513 T2667 T2666 punct ", ",tumors
R514 T2584 T2582 compound germline,mutations
R515 T2668 T2666 conj disorders,tumors
R516 T2669 T2668 prep of,disorders
R517 T2670 T2671 det the,bones
R518 T2586 T2582 prep in,mutations
R519 T2587 T2586 pobj APC,in
R520 T2671 T2669 pobj bones,of
R521 T2672 T2671 amod maxillary,bones
R522 T2588 T2589 amod familial,polypois
R523 T2673 T2672 cc and,maxillary
R524 T2674 T2672 conj skeletal,maxillary
R525 T2675 T2668 punct ", ",disorders
R526 T2589 T2585 dobj polypois,cause
R527 T2676 T2668 cc and,disorders
R528 T2677 T2678 amod dental,abnormalities
R529 T2590 T2589 amod adenomatous,polypois
R530 T2678 T2668 conj abnormalities,disorders
R531 T2679 T2680 punct [,6
R532 T2680 T2650 parataxis 6,are
R533 T2591 T2589 punct (,polypois
R534 T2681 T2680 punct ],6
R535 T2682 T2650 punct ", ",are
R536 T2683 T2650 advcl suggesting,are
R537 T2592 T2589 appos FAP,polypois
R538 T2684 T2685 det the,importance
R539 T2685 T2683 dobj importance,suggesting
R540 T2686 T2685 prep of,importance
R541 T2593 T2589 punct ),polypois
R542 T2687 T2688 compound APC,gene
R543 T2688 T2686 pobj gene,of
R544 T2689 T2688 nmod functions,gene
R545 T2594 T2589 cc and,polypois
R546 T2690 T2685 prep in,importance
R547 T2691 T2692 det these,systems
R548 T2692 T2690 pobj systems,in
R549 T2693 T2692 compound organ,systems
R550 T2694 T2637 punct .,develop
R551 T2696 T2697 mark Although,is
R552 T2595 T2596 poss its,variant
R553 T2697 T2709 advcl is,understood
R554 T2698 T2699 det the,role
R555 T2699 T2697 nsubj role,is
R556 T2596 T2589 conj variant,polypois
R557 T2700 T2699 prep of,role
R558 T2701 T2700 pobj APC,of
R559 T2702 T2699 prep in,role
R560 T2597 T2596 punct ", ",variant
R561 T2703 T2704 det the,initiation
R562 T2704 T2702 pobj initiation,in
R563 T2705 T2704 prep of,initiation
R564 T2706 T2707 amod human,cancer
R565 T2598 T2599 compound Gardner,syndrome
R566 T2707 T2705 pobj cancer,of
R567 T2708 T2707 amod colorectal,cancer
R568 T2599 T2596 appos syndrome,variant
R569 T2710 T2711 advmod well,established
R570 T2600 T2585 punct .,cause
R571 T2602 T2603 compound FAP,patients
R572 T2603 T2604 nsubjpass patients,characterized
R573 T2711 T2697 acomp established,is
R574 T2817 T2818 amod gastrointestinal,tumor
R575 T2712 T2709 punct ", ",understood
R576 T2713 T2714 poss its,role
R577 T2714 T2709 nsubjpass role,understood
R578 T2715 T2714 prep in,role
R579 T2716 T2717 amod other,processes
R580 T2717 T2715 pobj processes,in
R581 T2818 T2821 compound tumor,predisposition
R582 T2718 T2717 nmod tissue,processes
R583 T2719 T2718 cc and,tissue
R584 T2720 T2718 conj developmental,tissue
R585 T2819 T2817 cc and,gastrointestinal
R586 T2721 T2709 auxpass are,understood
R587 T2722 T2709 neg not,understood
R588 T2723 T2709 advmod well,understood
R589 T2820 T2817 conj other,gastrointestinal
R590 T2724 T2709 punct .,understood
R591 T2726 T2727 prep Given,becomes
R592 T2821 T2816 compound predisposition,phenotype
R593 T2728 T2729 det the,importance
R594 T2729 T2726 pobj importance,Given
R595 T2822 T2823 punct [,7
R596 T2730 T2729 prep of,importance
R597 T2731 T2730 pobj regulation,of
R598 T2732 T2731 prep of,regulation
R599 T2733 T2734 compound Wnt,signaling
R600 T2734 T2732 pobj signaling,of
R601 T2735 T2729 prep in,importance
R602 T2823 T2805 parataxis 7,show
R603 T2736 T2737 amod embryonic,formation
R604 T2737 T2735 pobj formation,in
R605 T2738 T2737 compound pattern,formation
R606 T2824 T2825 punct –,10
R607 T2739 T2737 cc and,formation
R608 T2740 T2737 conj morphogenesis,formation
R609 T2741 T2740 prep of,morphogenesis
R610 T2825 T2823 prep 10,7
R611 T2742 T2743 amod many,organs
R612 T2826 T2823 punct ],7
R613 T2827 T2805 punct .,show
R614 T2743 T2741 pobj organs,of
R615 T2744 T2727 punct ", ",becomes
R616 T2829 T2830 compound Mouse,embryos
R617 T2745 T2746 amod mechanistic,understanding
R618 T2746 T2727 nsubj understanding,becomes
R619 T2747 T2746 prep of,understanding
R620 T2748 T2747 pobj APC,of
R621 T2830 T2831 nsubj embryos,die
R622 T2749 T2748 prep in,APC
R623 T2750 T2749 pobj development,in
R624 T2751 T2749 cc and,in
R625 T2832 T2833 dep that,are
R626 T2752 T2749 conj in,in
R627 T2753 T2754 amod extracolonic,tissues
R628 T2754 T2752 pobj tissues,in
R629 T2755 T2727 acomp critical,becomes
R630 T2756 T2757 aux to,assess
R631 T2833 T2830 relcl are,embryos
R632 T2834 T2833 acomp homozygous,are
R633 T2757 T2755 xcomp assess,critical
R634 T2835 T2834 prep for,homozygous
R635 T2758 T2757 advmod better,assess
R636 T2836 T2837 det the,modification
R637 T2759 T2760 amod potential,events
R638 T2760 T2757 dobj events,assess
R639 T2761 T2760 amod adverse,events
R640 T2762 T2757 prep in,assess
R641 T2837 T2835 pobj modification,for
R642 T2763 T2762 pobj humans,in
R643 T2764 T2727 punct .,becomes
R644 T2838 T2837 amod genetic,modification
R645 T2766 T2767 nummod One,approach
R646 T2767 T2768 nsubj approach,is
R647 T2839 T2831 prep during,die
R648 T2769 T2770 aux to,understand
R649 T2840 T2839 pobj embryogenesis,during
R650 T2770 T2767 advcl understand,approach
R651 T2771 T2772 det the,role
R652 T2772 T2770 dobj role,understand
R653 T2773 T2772 prep of,role
R654 T2774 T2773 pobj Apc,of
R655 T2775 T2772 prep in,role
R656 T2841 T2831 punct ", ",die
R657 T2776 T2775 pobj development,in
R658 T2777 T2778 aux to,develop
R659 T2778 T2768 xcomp develop,is
R660 T2779 T2778 dobj mice,develop
R661 T2842 T2831 cc and,die
R662 T2780 T2779 prep with,mice
R663 T2781 T2782 det an,mutation
R664 T2843 T2844 nsubj some,survive
R665 T2782 T2780 pobj mutation,with
R666 T2783 T2782 amod inactivating,mutation
R667 T2784 T2782 compound Apc,mutation
R668 T2844 T2831 conj survive,die
R669 T2785 T2768 punct .,is
R670 T2787 T2788 amod Several,strains
R671 T2788 T2792 nsubjpass strains,described
R672 T2845 T2843 prep of,some
R673 T2789 T2790 advmod genetically,modified
R674 T2790 T2788 amod modified,strains
R675 T2791 T2788 compound mouse,strains
R676 T2846 T2847 det the,models
R677 T2793 T2788 prep for,strains
R678 T2794 T2793 pobj Apc,for
R679 T2847 T2845 pobj models,of
R680 T2795 T2792 aux have,described
R681 T2796 T2792 auxpass been,described
R682 T2797 T2798 punct [,7
R683 T2848 T2844 aux do,survive
R684 T2798 T2792 parataxis 7,described
R685 T2799 T2800 punct –,10
R686 T2800 T2798 prep 10,7
R687 T2801 T2798 punct ],7
R688 T2849 T2844 neg not,survive
R689 T2802 T2792 punct .,described
R690 T2850 T2844 prep beyond,survive
R691 T2804 T2805 nsubj Most,show
R692 T2806 T2804 prep of,Most
R693 T2851 T2850 pobj gastrulation,beyond
R694 T2807 T2808 det these,models
R695 T2808 T2806 pobj models,of
R696 T2809 T2804 punct ", ",Most
R697 T2810 T2804 prep in,Most
R698 T2852 T2853 punct [,11
R699 T2811 T2812 det the,state
R700 T2812 T2810 pobj state,in
R701 T2813 T2812 amod heterozygous,state
R702 T2853 T2844 parataxis 11,survive
R703 T2814 T2805 punct ", ",show
R704 T2815 T2816 det a,phenotype
R705 T2816 T2805 dobj phenotype,show
R706 T2854 T2853 nummod 8,11
R707 T2855 T2853 punct ",",11
R708 T2856 T2853 punct ],11
R709 T2923 T2911 nsubj we,generated
R710 T2924 T2911 dobj mice,generated
R711 T2925 T2924 acl containing,mice
R712 T2857 T2844 punct .,survive
R713 T2926 T2927 det a,allele
R714 T2859 T2860 det An,approach
R715 T2927 T2925 dobj allele,containing
R716 T2928 T2929 amod conditional,knockout
R717 T2929 T2927 nmod knockout,allele
R718 T2930 T2929 punct (,knockout
R719 T2860 T2862 nsubj approach,is
R720 T2931 T2929 appos CKO,knockout
R721 T2932 T2927 punct ),allele
R722 T2861 T2860 amod alternate,approach
R723 T2933 T2927 amod mutant,allele
R724 T2934 T2927 prep of,allele
R725 T2935 T2934 pobj Apc,of
R726 T2863 T2864 aux to,understand
R727 T2936 T2927 punct (,allele
R728 T2937 T2927 appos ApcCKO,allele
R729 T2938 T2911 punct ),generated
R730 T2939 T2911 punct .,generated
R731 T2864 T2860 advcl understand,approach
R732 T2941 T2942 det These,mice
R733 T2865 T2866 det the,role
R734 T2942 T2943 nsubjpass mice,mated
R735 T2944 T2943 auxpass were,mated
R736 T2866 T2864 dobj role,understand
R737 T2945 T2943 prep with,mated
R738 T2946 T2947 det a,strain
R739 T2947 T2945 pobj strain,with
R740 T2948 T2947 acl carrying,strain
R741 T2867 T2866 prep of,role
R742 T2949 T2950 compound Cre,recombinase
R743 T2950 T2948 dobj recombinase,carrying
R744 T2868 T2867 pobj Apc,of
R745 T2951 T2950 prep under,recombinase
R746 T2869 T2866 prep in,role
R747 T2952 T2953 det the,control
R748 T2953 T2951 pobj control,under
R749 T2954 T2953 prep of,control
R750 T2955 T2956 det the,promoter
R751 T2870 T2869 pobj development,in
R752 T2956 T2954 pobj promoter,of
R753 T2957 T2956 amod human,promoter
R754 T2958 T2956 nmod Keratin,promoter
R755 T2871 T2869 cc and,in
R756 T2959 T2958 nummod 14,Keratin
R757 T2960 T2958 punct (,Keratin
R758 T2961 T2958 appos K14,Keratin
R759 T2962 T2956 punct ),promoter
R760 T2963 T2956 punct ", ",promoter
R761 T2964 T2965 dep which,is
R762 T2872 T2871 punct /,and
R763 T2965 T2956 relcl is,promoter
R764 T2966 T2965 acomp active,is
R765 T2967 T2965 prep in,is
R766 T2873 T2871 cc or,and
R767 T2968 T2969 amod basal,cells
R768 T2969 T2967 pobj cells,in
R769 T2970 T2969 prep of,cells
R770 T2874 T2869 conj in,in
R771 T2971 T2970 pobj epidermis,of
R772 T2972 T2971 cc and,epidermis
R773 T2973 T2974 amod other,epithelia
R774 T2875 T2876 amod specific,tissues
R775 T2974 T2971 conj epithelia,epidermis
R776 T2975 T2974 amod stratified,epithelia
R777 T2976 T2943 punct .,mated
R778 T2876 T2874 pobj tissues,in
R779 T2978 T2979 nsubj We,report
R780 T2877 T2878 aux to,generate
R781 T2980 T2979 advmod here,report
R782 T2981 T2982 mark that,resulted
R783 T2982 T2979 ccomp resulted,report
R784 T2878 T2862 xcomp generate,is
R785 T2983 T2984 compound K14,promoter
R786 T2984 T2985 npadvmod promoter,driven
R787 T2985 T2987 amod driven,loss
R788 T2879 T2880 det a,strain
R789 T2986 T2985 punct -,driven
R790 T2987 T2982 nsubj loss,resulted
R791 T2988 T2987 prep of,loss
R792 T2880 T2878 dobj strain,generate
R793 T2989 T2988 pobj Apc,of
R794 T2990 T2982 prep in,resulted
R795 T2881 T2880 compound mouse,strain
R796 T2991 T2992 amod aberrant,development
R797 T2992 T2990 pobj development,in
R798 T2993 T2992 prep of,development
R799 T2882 T2883 dep that,carries
R800 T2994 T2995 amod several,organs
R801 T2995 T2993 pobj organs,of
R802 T2996 T2997 dep that,require
R803 T2883 T2880 relcl carries,strain
R804 T2997 T2995 relcl require,organs
R805 T2998 T2999 amod inductive,interactions
R806 T2999 T2997 dobj interactions,require
R807 T3000 T3001 amod epithelial,mesenchymal
R808 T3001 T2999 amod mesenchymal,interactions
R809 T3002 T3001 punct –,mesenchymal
R810 T3003 T2995 punct ", ",organs
R811 T2884 T2885 det a,allele
R812 T3004 T2995 prep including,organs
R813 T3005 T3006 compound hair,follicle
R814 T3006 T3004 pobj follicle,including
R815 T2885 T2883 dobj allele,carries
R816 T3007 T3006 punct ", ",follicle
R817 T3008 T3006 conj teeth,follicle
R818 T3009 T3008 punct ", ",teeth
R819 T2886 T2887 advmod conditionally,modified
R820 T3010 T3008 cc and,teeth
R821 T3011 T3008 conj thymus,teeth
R822 T3012 T2982 punct ", ",resulted
R823 T2887 T2885 amod modified,allele
R824 T3013 T2982 cc and,resulted
R825 T3014 T2982 conj resulted,resulted
R826 T2888 T2878 cc and,generate
R827 T2889 T2878 conj mate,generate
R828 T3015 T3014 prep in,resulted
R829 T2890 T2889 dobj it,mate
R830 T3016 T3017 amod neonatal,death
R831 T3017 T3015 pobj death,in
R832 T3018 T3014 prep in,resulted
R833 T2891 T2889 prep with,mate
R834 T3019 T3018 pobj mice,in
R835 T3020 T2979 punct .,report
R836 T2892 T2893 det a,strain
R837 T3022 T3023 nsubj We,found
R838 T3024 T3025 mark that,plays
R839 T2893 T2891 pobj strain,with
R840 T3025 T3023 ccomp plays,found
R841 T3026 T3025 nsubj Apc,plays
R842 T2894 T2893 compound mouse,strain
R843 T3027 T3028 det a,role
R844 T3028 T3025 dobj role,plays
R845 T2895 T2896 dep that,facilitates
R846 T2896 T2893 relcl facilitates,strain
R847 T2897 T2898 det the,modification
R848 T3029 T3028 amod crucial,role
R849 T3030 T3025 prep in,plays
R850 T3031 T3030 pobj determinations,in
R851 T2898 T2896 dobj modification,facilitates
R852 T3032 T3031 prep of,determinations
R853 T3033 T3034 compound cell,fates
R854 T2899 T2898 prep of,modification
R855 T3034 T3032 pobj fates,of
R856 T3035 T3025 prep during,plays
R857 T2900 T2901 det the,allele
R858 T3036 T3037 det the,development
R859 T3037 T3035 pobj development,during
R860 T3038 T3037 amod embryonic,development
R861 T3039 T3025 punct ", ",plays
R862 T3040 T3041 advmod possibly,via
R863 T3041 T3025 prep via,plays
R864 T2901 T2899 pobj allele,of
R865 T3042 T3043 amod temporal,regulation
R866 T3043 T3041 pobj regulation,via
R867 T3044 T3042 cc and,temporal
R868 T3045 T3046 npadvmod tissue,specific
R869 T2902 T2901 amod conditional,allele
R870 T3046 T3042 conj specific,temporal
R871 T3047 T3046 punct -,specific
R872 T3048 T3043 prep of,regulation
R873 T2903 T2898 prep in,modification
R874 T3049 T3050 compound β,catenin
R875 T3050 T3052 compound catenin,levels
R876 T2904 T2905 amod specific,lineages
R877 T3051 T3050 punct -,catenin
R878 T3052 T3048 pobj levels,of
R879 T3053 T3052 prep in,levels
R880 T2905 T2903 pobj lineages,in
R881 T3054 T3055 det the,skin
R882 T3055 T3053 pobj skin,in
R883 T3056 T3055 punct ", ",skin
R884 T2906 T2905 compound cell,lineages
R885 T3057 T3058 poss its,appendages
R886 T3058 T3055 appos appendages,skin
R887 T3059 T3053 punct ", ",in
R888 T2907 T2862 punct .,is
R889 T3060 T3053 cc and,in
R890 T3061 T3053 conj in,in
R891 T3062 T3063 det the,thymus
R892 T2909 T2910 aux To,assess
R893 T3063 T3061 pobj thymus,in
R894 T3064 T3023 punct .,found
R895 T2910 T2911 advcl assess,generated
R896 T2912 T2913 det the,role
R897 T2913 T2910 dobj role,assess
R898 T2914 T2913 prep of,role
R899 T2915 T2914 pobj Apc,of
R900 T2916 T2913 prep in,role
R901 T2917 T2918 amod different,stages
R902 T2918 T2916 pobj stages,in
R903 T2919 T2918 prep of,stages
R904 T2920 T2919 pobj life,of
R905 T2921 T2910 advmod systematically,assess
R906 T2922 T2911 punct ", ",generated