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PMC:1564426 / 11691-18673 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7674 0-3 NN denotes K14
T7676 3-4 HYPH denotes -
T7675 4-10 VBN denotes Driven
T7677 11-15 NN denotes Loss
T7679 16-18 IN denotes of
T7680 19-22 NN denotes Apc
T7678 23-30 VBZ denotes Results
T7681 31-33 IN denotes in
T7682 34-40 JJ denotes Severe
T7684 41-47 NN denotes Growth
T7683 48-59 NN denotes Retardation
T7685 60-63 CC denotes and
T7686 64-69 JJ denotes Early
T7687 70-79 NN denotes Lethality
T7688 79-243 sentence denotes To introduce the mutation of Apc into cells expressing K14, we crossed WW6 ES cell–derived [15] ApcCKO/+ mice with K14-cre recombinase mice in FVB background [16].
T7689 80-82 TO denotes To
T7690 83-92 VB denotes introduce
T7692 93-96 DT denotes the
T7693 97-105 NN denotes mutation
T7694 106-108 IN denotes of
T7695 109-112 NN denotes Apc
T7696 113-117 IN denotes into
T7697 118-123 NNS denotes cells
T7698 124-134 VBG denotes expressing
T7699 135-138 NN denotes K14
T7700 138-140 , denotes ,
T7701 140-142 PRP denotes we
T7691 143-150 VBD denotes crossed
T7702 151-154 NN denotes WW6
T7704 155-157 NN denotes ES
T7705 158-162 NN denotes cell
T7707 162-163 HYPH denotes –
T7706 163-170 VBN denotes derived
T7708 171-172 -LRB- denotes [
T7709 172-174 CD denotes 15
T7710 174-175 -RRB- denotes ]
T7711 176-182 NN denotes ApcCKO
T7712 182-183 HYPH denotes /
T7713 183-184 SYM denotes +
T7703 185-189 NNS denotes mice
T7714 190-194 IN denotes with
T7715 195-198 NN denotes K14
T7717 198-199 HYPH denotes -
T7716 199-202 NN denotes cre
T7719 203-214 NN denotes recombinase
T7718 215-219 NNS denotes mice
T7720 220-222 IN denotes in
T7721 223-226 NN denotes FVB
T7722 227-237 NN denotes background
T7723 238-239 -LRB- denotes [
T7724 239-241 CD denotes 16
T7725 241-242 -RRB- denotes ]
T7726 242-243 . denotes .
T7727 243-314 sentence denotes The K14-cre; ApcCKO/+ mice were normal in appearance and were fertile.
T7728 244-247 DT denotes The
T7730 248-251 NN denotes K14
T7732 251-252 HYPH denotes -
T7731 252-255 NN denotes cre
T7733 255-256 : denotes ;
T7734 257-263 NN denotes ApcCKO
T7735 263-264 HYPH denotes /
T7736 264-265 SYM denotes +
T7729 266-270 NNS denotes mice
T7737 271-275 VBD denotes were
T7738 276-282 JJ denotes normal
T7739 283-285 IN denotes in
T7740 286-296 NN denotes appearance
T7741 297-300 CC denotes and
T7742 301-305 VBD denotes were
T7743 306-313 JJ denotes fertile
T7744 313-314 . denotes .
T7745 314-456 sentence denotes K14-cre; ApcCKO/+ males were crossed to ApcCKO/CKO females to avoid the potential deleter effect in oocytes of K14-cre–positive females [17].
T7746 315-318 NN denotes K14
T7748 318-319 HYPH denotes -
T7747 319-322 NN denotes cre
T7750 322-323 : denotes ;
T7751 324-330 NN denotes ApcCKO
T7752 330-331 HYPH denotes /
T7753 331-332 SYM denotes +
T7749 333-338 NNS denotes males
T7755 339-343 VBD denotes were
T7754 344-351 VBN denotes crossed
T7756 352-354 IN denotes to
T7757 355-361 NN denotes ApcCKO
T7759 361-362 HYPH denotes /
T7758 362-365 NN denotes CKO
T7760 366-373 NNS denotes females
T7761 374-376 TO denotes to
T7762 377-382 VB denotes avoid
T7763 383-386 DT denotes the
T7765 387-396 JJ denotes potential
T7766 397-404 NN denotes deleter
T7764 405-411 NN denotes effect
T7767 412-414 IN denotes in
T7768 415-422 NNS denotes oocytes
T7769 423-425 IN denotes of
T7770 426-429 NN denotes K14
T7772 429-430 HYPH denotes -
T7771 430-433 NN denotes cre
T7774 433-434 HYPH denotes –
T7773 434-442 JJ denotes positive
T7775 443-450 NNS denotes females
T7776 451-452 -LRB- denotes [
T7777 452-454 CD denotes 17
T7778 454-455 -RRB- denotes ]
T7779 455-456 . denotes .
T7780 456-656 sentence denotes The mice were intercrossed thereafter for maintenance; hence, the mice used for analysis were in a mixed background of FVB, 129/S, and C57BL/6 in similar proportions, with minimal contribution of SJ.
T7781 457-460 DT denotes The
T7782 461-465 NNS denotes mice
T7784 466-470 VBD denotes were
T7783 471-483 VBN denotes intercrossed
T7786 484-494 RB denotes thereafter
T7787 495-498 IN denotes for
T7788 499-510 NN denotes maintenance
T7789 510-511 : denotes ;
T7790 512-517 RB denotes hence
T7791 517-519 , denotes ,
T7792 519-522 DT denotes the
T7793 523-527 NNS denotes mice
T7794 528-532 VBN denotes used
T7795 533-536 IN denotes for
T7796 537-545 NN denotes analysis
T7785 546-550 VBD denotes were
T7797 551-553 IN denotes in
T7798 554-555 DT denotes a
T7800 556-561 VBN denotes mixed
T7799 562-572 NN denotes background
T7801 573-575 IN denotes of
T7802 576-579 NN denotes FVB
T7803 579-581 , denotes ,
T7804 581-584 CD denotes 129
T7806 584-585 HYPH denotes /
T7805 585-586 NN denotes S
T7807 586-588 , denotes ,
T7808 588-591 CC denotes and
T7809 592-597 NN denotes C57BL
T7810 597-598 HYPH denotes /
T7811 598-599 CD denotes 6
T7812 600-602 IN denotes in
T7813 603-610 JJ denotes similar
T7814 611-622 NNS denotes proportions
T7815 622-624 , denotes ,
T7816 624-628 IN denotes with
T7817 629-636 JJ denotes minimal
T7818 637-649 NN denotes contribution
T7819 650-652 IN denotes of
T7820 653-655 NN denotes SJ
T7821 655-656 . denotes .
T7822 656-962 sentence denotes The K14 promoter is a commonly used epidermal cell promoter because of its expression by the mitotically active cells of the epidermis and its appendages in mature skin [18], but most notably it is active in embryonic ectoderm as early as the single layered ectodermal stage of embryonic day (E) 9.5 [19].
T7823 657-660 DT denotes The
T7825 661-664 NN denotes K14
T7824 665-673 NN denotes promoter
T7826 674-676 VBZ denotes is
T7827 677-678 DT denotes a
T7829 679-687 RB denotes commonly
T7830 688-692 VBN denotes used
T7831 693-702 JJ denotes epidermal
T7832 703-707 NN denotes cell
T7828 708-716 NN denotes promoter
T7833 717-724 IN denotes because
T7834 725-727 IN denotes of
T7835 728-731 PRP$ denotes its
T7836 732-742 NN denotes expression
T7837 743-745 IN denotes by
T7838 746-749 DT denotes the
T7840 750-761 RB denotes mitotically
T7841 762-768 JJ denotes active
T7839 769-774 NNS denotes cells
T7842 775-777 IN denotes of
T7843 778-781 DT denotes the
T7844 782-791 NN denotes epidermis
T7845 792-795 CC denotes and
T7846 796-799 PRP$ denotes its
T7847 800-810 NNS denotes appendages
T7848 811-813 IN denotes in
T7849 814-820 JJ denotes mature
T7850 821-825 NN denotes skin
T7851 826-827 -LRB- denotes [
T7852 827-829 CD denotes 18
T7853 829-830 -RRB- denotes ]
T7854 830-832 , denotes ,
T7855 832-835 CC denotes but
T7856 836-840 RBS denotes most
T7857 841-848 RB denotes notably
T7859 849-851 PRP denotes it
T7858 852-854 VBZ denotes is
T7860 855-861 JJ denotes active
T7861 862-864 IN denotes in
T7862 865-874 JJ denotes embryonic
T7863 875-883 NN denotes ectoderm
T7864 884-886 RB denotes as
T7865 887-892 RB denotes early
T7866 893-895 IN denotes as
T7867 896-899 DT denotes the
T7869 900-906 JJ denotes single
T7870 907-914 VBN denotes layered
T7871 915-925 JJ denotes ectodermal
T7868 926-931 NN denotes stage
T7872 932-934 IN denotes of
T7873 935-944 JJ denotes embryonic
T7874 945-948 NN denotes day
T7875 949-950 -LRB- denotes (
T7876 950-951 NN denotes E
T7877 951-952 -RRB- denotes )
T7878 953-956 CD denotes 9.5
T7879 957-958 -LRB- denotes [
T7880 958-960 CD denotes 19
T7881 960-961 -RRB- denotes ]
T7882 961-962 . denotes .
T7883 962-1079 sentence denotes A restricted expression of K14 is also found in thymic epithelial cells (TECs) in the medulla of normal thymus [20].
T7884 963-964 DT denotes A
T7886 965-975 JJ denotes restricted
T7885 976-986 NN denotes expression
T7888 987-989 IN denotes of
T7889 990-993 NN denotes K14
T7890 994-996 VBZ denotes is
T7891 997-1001 RB denotes also
T7887 1002-1007 VBN denotes found
T7892 1008-1010 IN denotes in
T7893 1011-1017 JJ denotes thymic
T7895 1018-1028 JJ denotes epithelial
T7894 1029-1034 NNS denotes cells
T7896 1035-1036 -LRB- denotes (
T7897 1036-1040 NNS denotes TECs
T7898 1040-1041 -RRB- denotes )
T7899 1042-1044 IN denotes in
T7900 1045-1048 DT denotes the
T7901 1049-1056 NN denotes medulla
T7902 1057-1059 IN denotes of
T7903 1060-1066 JJ denotes normal
T7904 1067-1073 NN denotes thymus
T7905 1074-1075 -LRB- denotes [
T7906 1075-1077 CD denotes 20
T7907 1077-1078 -RRB- denotes ]
T7908 1078-1079 . denotes .
T7909 1079-1211 sentence denotes We genotyped a total of 458 pups (8–10 d old) from 67 litters resulting from crosses between K14-cre; ApcCKO/+ and ApcCKO/CKO mice.
T7910 1080-1082 PRP denotes We
T7911 1083-1092 VBD denotes genotyped
T7912 1093-1094 DT denotes a
T7914 1095-1100 NN denotes total
T7915 1101-1103 IN denotes of
T7913 1104-1107 CD denotes 458
T7916 1108-1112 NNS denotes pups
T7917 1113-1114 -LRB- denotes (
T7919 1114-1115 CD denotes 8
T7921 1115-1116 SYM denotes –
T7920 1116-1118 CD denotes 10
T7922 1119-1120 NNS denotes d
T7918 1121-1124 JJ denotes old
T7923 1124-1125 -RRB- denotes )
T7924 1126-1130 IN denotes from
T7925 1131-1133 CD denotes 67
T7926 1134-1141 NNS denotes litters
T7927 1142-1151 VBG denotes resulting
T7928 1152-1156 IN denotes from
T7929 1157-1164 NNS denotes crosses
T7930 1165-1172 IN denotes between
T7931 1173-1176 NN denotes K14
T7933 1176-1177 HYPH denotes -
T7932 1177-1180 NN denotes cre
T7935 1180-1181 : denotes ;
T7936 1182-1188 NN denotes ApcCKO
T7937 1188-1189 HYPH denotes /
T7938 1189-1190 SYM denotes +
T7939 1191-1194 CC denotes and
T7940 1195-1201 NN denotes ApcCKO
T7942 1201-1202 HYPH denotes /
T7941 1202-1205 NN denotes CKO
T7934 1206-1210 NNS denotes mice
T7943 1210-1211 . denotes .
T7944 1211-1428 sentence denotes The mutant mice of the genotype K14-cre; ApcCKO/CKO (hereafter, KA mutant) were born, but the observed frequency of KA mutants was much less than expected (78 of 458 [17.0%]; p < 0.0005 Chi-square analysis, Table 1).
T7945 1212-1215 DT denotes The
T7947 1216-1222 JJ denotes mutant
T7946 1223-1227 NNS denotes mice
T7949 1228-1230 IN denotes of
T7950 1231-1234 DT denotes the
T7951 1235-1243 NN denotes genotype
T7952 1244-1247 NN denotes K14
T7954 1247-1248 HYPH denotes -
T7953 1248-1251 NN denotes cre
T7955 1251-1252 : denotes ;
T7956 1253-1259 NN denotes ApcCKO
T7958 1259-1260 HYPH denotes /
T7957 1260-1263 NN denotes CKO
T7959 1264-1265 -LRB- denotes (
T7961 1265-1274 RB denotes hereafter
T7962 1274-1276 , denotes ,
T7963 1276-1278 NN denotes KA
T7960 1279-1285 NN denotes mutant
T7964 1285-1286 -RRB- denotes )
T7965 1287-1291 VBD denotes were
T7948 1292-1296 VBN denotes born
T7966 1296-1298 , denotes ,
T7967 1298-1301 CC denotes but
T7968 1302-1305 DT denotes the
T7970 1306-1314 VBN denotes observed
T7969 1315-1324 NN denotes frequency
T7972 1325-1327 IN denotes of
T7973 1328-1330 NN denotes KA
T7974 1331-1338 NNS denotes mutants
T7971 1339-1342 VBD denotes was
T7975 1343-1347 RB denotes much
T7976 1348-1352 JJR denotes less
T7977 1353-1357 IN denotes than
T7978 1358-1366 VBN denotes expected
T7979 1367-1368 -LRB- denotes (
T7981 1368-1370 CD denotes 78
T7982 1371-1373 IN denotes of
T7983 1374-1377 CD denotes 458
T7984 1378-1379 -LRB- denotes [
T7986 1379-1383 CD denotes 17.0
T7985 1383-1384 NN denotes %
T7987 1384-1385 -RRB- denotes ]
T7988 1385-1386 : denotes ;
T7989 1387-1388 NN denotes p
T7991 1389-1390 SYM denotes <
T7992 1391-1397 CD denotes 0.0005
T7993 1398-1401 NN denotes Chi
T7995 1401-1402 HYPH denotes -
T7994 1402-1408 NN denotes square
T7990 1409-1417 NN denotes analysis
T7996 1417-1419 , denotes ,
T7980 1419-1424 NN denotes Table
T7997 1425-1426 CD denotes 1
T7998 1426-1427 -RRB- denotes )
T7999 1427-1428 . denotes .
T8000 1428-1591 sentence denotes To assess the basis for the neonatal lethality of KA mutants, we monitored three litters from birth to weaning by measuring the body weight of each pup every day.
T8001 1429-1431 TO denotes To
T8002 1432-1438 VB denotes assess
T8004 1439-1442 DT denotes the
T8005 1443-1448 NN denotes basis
T8006 1449-1452 IN denotes for
T8007 1453-1456 DT denotes the
T8009 1457-1465 JJ denotes neonatal
T8008 1466-1475 NN denotes lethality
T8010 1476-1478 IN denotes of
T8011 1479-1481 NN denotes KA
T8012 1482-1489 NNS denotes mutants
T8013 1489-1491 , denotes ,
T8014 1491-1493 PRP denotes we
T8003 1494-1503 VBD denotes monitored
T8015 1504-1509 CD denotes three
T8016 1510-1517 NNS denotes litters
T8017 1518-1522 IN denotes from
T8018 1523-1528 NN denotes birth
T8019 1529-1531 IN denotes to
T8020 1532-1539 VBG denotes weaning
T8021 1540-1542 IN denotes by
T8022 1543-1552 VBG denotes measuring
T8023 1553-1556 DT denotes the
T8025 1557-1561 NN denotes body
T8024 1562-1568 NN denotes weight
T8026 1569-1571 IN denotes of
T8027 1572-1576 DT denotes each
T8028 1577-1580 NN denotes pup
T8029 1581-1586 DT denotes every
T8030 1587-1590 NN denotes day
T8031 1590-1591 . denotes .
T8032 1591-1783 sentence denotes A total of 25 pups were born from three litters, of which 7 (28%) were confirmed to be K14-cre; ApcCKO/CKO by genotyping, indicating that KA mutants were born in the expected Mendelian ratio.
T8033 1592-1593 DT denotes A
T8035 1594-1599 NN denotes total
T8036 1600-1602 IN denotes of
T8034 1603-1605 CD denotes 25
T8037 1606-1610 NNS denotes pups
T8039 1611-1615 VBD denotes were
T8038 1616-1620 VBN denotes born
T8040 1621-1625 IN denotes from
T8041 1626-1631 CD denotes three
T8042 1632-1639 NNS denotes litters
T8043 1639-1641 , denotes ,
T8044 1641-1643 IN denotes of
T8046 1644-1649 WDT denotes which
T8047 1650-1651 CD denotes 7
T8048 1652-1653 -LRB- denotes (
T8050 1653-1655 CD denotes 28
T8049 1655-1656 NN denotes %
T8051 1656-1657 -RRB- denotes )
T8052 1658-1662 VBD denotes were
T8045 1663-1672 VBN denotes confirmed
T8053 1673-1675 TO denotes to
T8054 1676-1678 VB denotes be
T8055 1679-1682 NN denotes K14
T8057 1682-1683 HYPH denotes -
T8056 1683-1686 NN denotes cre
T8058 1686-1687 : denotes ;
T8059 1688-1694 NN denotes ApcCKO
T8061 1694-1695 HYPH denotes /
T8060 1695-1698 NN denotes CKO
T8062 1699-1701 IN denotes by
T8063 1702-1712 NN denotes genotyping
T8064 1712-1714 , denotes ,
T8065 1714-1724 VBG denotes indicating
T8066 1725-1729 IN denotes that
T8068 1730-1732 NN denotes KA
T8069 1733-1740 NNS denotes mutants
T8070 1741-1745 VBD denotes were
T8067 1746-1750 VBN denotes born
T8071 1751-1753 IN denotes in
T8072 1754-1757 DT denotes the
T8074 1758-1766 VBN denotes expected
T8075 1767-1776 JJ denotes Mendelian
T8073 1777-1782 NN denotes ratio
T8076 1782-1783 . denotes .
T8077 1783-1938 sentence denotes The KA mutant pups were nursed normally, and there was milk in their stomachs during the first 2 or 3 d after birth, but they failed to thrive (Figure 2).
T8078 1784-1787 DT denotes The
T8080 1788-1790 NN denotes KA
T8081 1791-1797 JJ denotes mutant
T8079 1798-1802 NNS denotes pups
T8083 1803-1807 VBD denotes were
T8082 1808-1814 VBN denotes nursed
T8084 1815-1823 RB denotes normally
T8085 1823-1825 , denotes ,
T8086 1825-1828 CC denotes and
T8087 1829-1834 EX denotes there
T8088 1835-1838 VBD denotes was
T8089 1839-1843 NN denotes milk
T8090 1844-1846 IN denotes in
T8091 1847-1852 PRP$ denotes their
T8092 1853-1861 NNS denotes stomachs
T8093 1862-1868 IN denotes during
T8094 1869-1872 DT denotes the
T8096 1873-1878 JJ denotes first
T8097 1879-1880 CD denotes 2
T8098 1881-1883 CC denotes or
T8099 1884-1885 CD denotes 3
T8095 1886-1887 NNS denotes d
T8100 1888-1893 IN denotes after
T8101 1894-1899 NN denotes birth
T8102 1899-1901 , denotes ,
T8103 1901-1904 CC denotes but
T8104 1905-1909 PRP denotes they
T8105 1910-1916 VBD denotes failed
T8106 1917-1919 TO denotes to
T8107 1920-1926 VB denotes thrive
T8108 1927-1928 -LRB- denotes (
T8109 1928-1934 NN denotes Figure
T8110 1935-1936 CD denotes 2
T8111 1936-1937 -RRB- denotes )
T8112 1937-1938 . denotes .
T8113 1938-2120 sentence denotes By postnatal day (P) 8–10, at the time of genotyping, many KA mutant pups were considerably smaller than their littermates (Figure 2B–2F) and some have died at or prior to this age.
T8114 1939-1941 IN denotes By
T8116 1942-1951 JJ denotes postnatal
T8117 1952-1955 NN denotes day
T8118 1956-1957 -LRB- denotes (
T8119 1957-1958 NN denotes P
T8120 1958-1959 -RRB- denotes )
T8121 1960-1961 CD denotes 8
T8122 1961-1962 SYM denotes –
T8123 1962-1964 CD denotes 10
T8124 1964-1966 , denotes ,
T8125 1966-1968 IN denotes at
T8126 1969-1972 DT denotes the
T8127 1973-1977 NN denotes time
T8128 1978-1980 IN denotes of
T8129 1981-1991 NN denotes genotyping
T8130 1991-1993 , denotes ,
T8131 1993-1997 JJ denotes many
T8133 1998-2000 NN denotes KA
T8134 2001-2007 JJ denotes mutant
T8132 2008-2012 NNS denotes pups
T8115 2013-2017 VBD denotes were
T8135 2018-2030 RB denotes considerably
T8136 2031-2038 JJR denotes smaller
T8137 2039-2043 IN denotes than
T8138 2044-2049 PRP$ denotes their
T8139 2050-2061 NNS denotes littermates
T8140 2062-2063 -LRB- denotes (
T8142 2063-2069 NN denotes Figure
T8141 2070-2072 NN denotes 2B
T8143 2072-2073 SYM denotes –
T8144 2073-2075 NN denotes 2F
T8145 2075-2076 -RRB- denotes )
T8146 2077-2080 CC denotes and
T8147 2081-2085 DT denotes some
T8149 2086-2090 VBP denotes have
T8148 2091-2095 VBN denotes died
T8150 2096-2098 IN denotes at
T8151 2099-2101 CC denotes or
T8152 2102-2107 JJ denotes prior
T8153 2108-2110 IN denotes to
T8154 2111-2115 DT denotes this
T8155 2116-2119 NN denotes age
T8156 2119-2120 . denotes .
T8157 2120-2164 sentence denotes None of KA mutants survived to weaning age.
T8158 2121-2125 NN denotes None
T8160 2126-2128 IN denotes of
T8161 2129-2131 NN denotes KA
T8162 2132-2139 NNS denotes mutants
T8159 2140-2148 VBD denotes survived
T8163 2149-2151 IN denotes to
T8164 2152-2159 VBG denotes weaning
T8165 2160-2163 NN denotes age
T8166 2163-2164 . denotes .
T8167 2164-3709 sentence denotes Table 1 Genotype Distribution of Progeny from the Matings Figure 2 Postnatal Mortality and Stunted Growth in K14-cre; ApcCKO/CKO Mutant Mice Animals whose genotype is either heterozygous or homozygous for the wild-type Apc allele are referred to as normal (N); those whose genotype are K14-cre; ApcCKO/CKO and show the presence of K14-cre–recombined mutant Apc allele are called mutant (M). (A) Two P3 mutant mice, M1 and M2, and their normal littermates, showing size variation among mutants. (B) P8 mutant mouse (right) and a normal littermate. Note sparseness of hair coat and abnormal ears. (C–D) Vibrissae of whisker pads are short and oddly angled in a P12 mutant mouse (C), relative to control (D). Note the lack of incisors in the mutant. (E) A P17 mutant mouse (right) with its littermate. Its bare forehead, dorsal median line, and abnormal ears are evident. (F) Growth curve of mutants and normal littermates. Mutants exhibit stunted growth, which became more prominent as they aged, and weigh significantly less than littermates from P8 (p < 0.05). (G) Comparison of mutant and normal thymus from P3 mice. The mutant thymus (left) is dramatically smaller for its age compared to the normal littermate (right). The scale bar equals 1 mm. (H) Skeletal preparations of normal (left) and mutant (right), showing differences in development of both incisor (I) and molar (M) teeth. The ability of whole embryos to exclude blue dye was used to examine the epidermal barrier, normally acquired beginning at E16 and complete by E18.5 [21].
T8168 2165-3558 DT denotes Table 1 Genotype Distribution of Progeny from the Matings Figure 2 Postnatal Mortality and Stunted Growth in K14-cre; ApcCKO/CKO Mutant Mice Animals whose genotype is either heterozygous or homozygous for the wild-type Apc allele are referred to as normal (N); those whose genotype are K14-cre; ApcCKO/CKO and show the presence of K14-cre–recombined mutant Apc allele are called mutant (M). (A) Two P3 mutant mice, M1 and M2, and their normal littermates, showing size variation among mutants. (B) P8 mutant mouse (right) and a normal littermate. Note sparseness of hair coat and abnormal ears. (C–D) Vibrissae of whisker pads are short and oddly angled in a P12 mutant mouse (C), relative to control (D). Note the lack of incisors in the mutant. (E) A P17 mutant mouse (right) with its littermate. Its bare forehead, dorsal median line, and abnormal ears are evident. (F) Growth curve of mutants and normal littermates. Mutants exhibit stunted growth, which became more prominent as they aged, and weigh significantly less than littermates from P8 (p < 0.05). (G) Comparison of mutant and normal thymus from P3 mice. The mutant thymus (left) is dramatically smaller for its age compared to the normal littermate (right). The scale bar equals 1 mm. (H) Skeletal preparations of normal (left) and mutant (right), showing differences in development of both incisor (I) and molar (M) teeth. The
T8169 3559-3566 NN denotes ability
T8171 3567-3569 IN denotes of
T8172 3570-3575 JJ denotes whole
T8173 3576-3583 NNS denotes embryos
T8174 3584-3586 TO denotes to
T8175 3587-3594 VB denotes exclude
T8176 3595-3599 JJ denotes blue
T8177 3600-3603 NN denotes dye
T8178 3604-3607 VBD denotes was
T8170 3608-3612 VBN denotes used
T8179 3613-3615 TO denotes to
T8180 3616-3623 VB denotes examine
T8181 3624-3627 DT denotes the
T8183 3628-3637 JJ denotes epidermal
T8182 3638-3645 NN denotes barrier
T8184 3645-3647 , denotes ,
T8185 3647-3655 RB denotes normally
T8186 3656-3664 VBN denotes acquired
T8187 3665-3674 VBG denotes beginning
T8188 3675-3677 IN denotes at
T8189 3678-3681 NN denotes E16
T8190 3682-3685 CC denotes and
T8191 3686-3694 JJ denotes complete
T8192 3695-3697 IN denotes by
T8193 3698-3703 NN denotes E18.5
T8194 3704-3705 -LRB- denotes [
T8195 3705-3707 CD denotes 21
T8196 3707-3708 -RRB- denotes ]
T8197 3708-3709 . denotes .
T8198 3709-3854 sentence denotes Analyses of E17.5–E18.5 KA mutants showed that they were able to exclude blue dye, indicating that the epidermal barrier was intact (Figure S2).
T8199 3710-3718 NNS denotes Analyses
T8201 3719-3721 IN denotes of
T8202 3722-3727 NN denotes E17.5
T8204 3727-3728 SYM denotes –
T8205 3728-3733 NN denotes E18.5
T8206 3734-3736 NN denotes KA
T8203 3737-3744 NNS denotes mutants
T8200 3745-3751 VBD denotes showed
T8207 3752-3756 IN denotes that
T8209 3757-3761 PRP denotes they
T8208 3762-3766 VBD denotes were
T8210 3767-3771 JJ denotes able
T8211 3772-3774 TO denotes to
T8212 3775-3782 VB denotes exclude
T8213 3783-3787 JJ denotes blue
T8214 3788-3791 NN denotes dye
T8215 3791-3793 , denotes ,
T8216 3793-3803 VBG denotes indicating
T8217 3804-3808 IN denotes that
T8219 3809-3812 DT denotes the
T8221 3813-3822 JJ denotes epidermal
T8220 3823-3830 NN denotes barrier
T8218 3831-3834 VBD denotes was
T8222 3835-3841 JJ denotes intact
T8223 3842-3843 -LRB- denotes (
T8225 3843-3849 NN denotes Figure
T8224 3850-3852 NN denotes S2
T8226 3852-3853 -RRB- denotes )
T8227 3853-3854 . denotes .
T8228 3854-4102 sentence denotes At these embryonic ages, there were no differences in size between the mutants and their littermates, but the mutants showed a patch of “birthmark” or dark pigmentation on their foreheads and a dark median line that ran caudally from head to tail.
T8229 3855-3857 IN denotes At
T8231 3858-3863 DT denotes these
T8233 3864-3873 JJ denotes embryonic
T8232 3874-3878 NNS denotes ages
T8234 3878-3880 , denotes ,
T8235 3880-3885 EX denotes there
T8230 3886-3890 VBD denotes were
T8236 3891-3893 DT denotes no
T8237 3894-3905 NNS denotes differences
T8238 3906-3908 IN denotes in
T8239 3909-3913 NN denotes size
T8240 3914-3921 IN denotes between
T8241 3922-3925 DT denotes the
T8242 3926-3933 NNS denotes mutants
T8243 3934-3937 CC denotes and
T8244 3938-3943 PRP$ denotes their
T8245 3944-3955 NNS denotes littermates
T8246 3955-3957 , denotes ,
T8247 3957-3960 CC denotes but
T8248 3961-3964 DT denotes the
T8249 3965-3972 NNS denotes mutants
T8250 3973-3979 VBD denotes showed
T8251 3980-3981 DT denotes a
T8252 3982-3987 NN denotes patch
T8253 3988-3990 IN denotes of
T8254 3991-3992 `` denotes “
T8255 3992-4001 NN denotes birthmark
T8256 4001-4002 '' denotes ”
T8257 4003-4005 CC denotes or
T8258 4006-4010 JJ denotes dark
T8259 4011-4023 NN denotes pigmentation
T8260 4024-4026 IN denotes on
T8261 4027-4032 PRP$ denotes their
T8262 4033-4042 NNS denotes foreheads
T8263 4043-4046 CC denotes and
T8264 4047-4048 DT denotes a
T8266 4049-4053 JJ denotes dark
T8267 4054-4060 JJ denotes median
T8265 4061-4065 NN denotes line
T8268 4066-4070 WDT denotes that
T8269 4071-4074 VBD denotes ran
T8270 4075-4083 RB denotes caudally
T8271 4084-4088 IN denotes from
T8272 4089-4093 NN denotes head
T8273 4094-4096 IN denotes to
T8274 4097-4101 NN denotes tail
T8275 4101-4102 . denotes .
T8276 4102-4209 sentence denotes Their external ears or pinnae were shriveled in appearance and pigmented compared to those of littermates.
T8277 4103-4108 PRP$ denotes Their
T8279 4109-4117 JJ denotes external
T8278 4118-4122 NNS denotes ears
T8281 4123-4125 CC denotes or
T8282 4126-4132 NNS denotes pinnae
T8280 4133-4137 VBD denotes were
T8283 4138-4147 JJ denotes shriveled
T8284 4148-4150 IN denotes in
T8285 4151-4161 NN denotes appearance
T8286 4162-4165 CC denotes and
T8287 4166-4175 JJ denotes pigmented
T8288 4176-4184 VBN denotes compared
T8289 4185-4187 IN denotes to
T8290 4188-4193 DT denotes those
T8291 4194-4196 IN denotes of
T8292 4197-4208 NNS denotes littermates
T8293 4208-4209 . denotes .
T8294 4209-4352 sentence denotes External characteristics of KA mutants that were evident at E18.5 persisted after birth and became more prominent as they grew (Figure 2A–2F).
T8295 4210-4218 JJ denotes External
T8296 4219-4234 NNS denotes characteristics
T8298 4235-4237 IN denotes of
T8299 4238-4240 NN denotes KA
T8300 4241-4248 NNS denotes mutants
T8301 4249-4253 WDT denotes that
T8302 4254-4258 VBD denotes were
T8303 4259-4266 JJ denotes evident
T8304 4267-4269 IN denotes at
T8305 4270-4275 NN denotes E18.5
T8297 4276-4285 VBD denotes persisted
T8306 4286-4291 IN denotes after
T8307 4292-4297 NN denotes birth
T8308 4298-4301 CC denotes and
T8309 4302-4308 VBD denotes became
T8310 4309-4313 RBR denotes more
T8311 4314-4323 JJ denotes prominent
T8312 4324-4326 IN denotes as
T8314 4327-4331 PRP denotes they
T8313 4332-4336 VBD denotes grew
T8315 4337-4338 -LRB- denotes (
T8317 4338-4344 NN denotes Figure
T8316 4345-4347 NN denotes 2A
T8318 4347-4348 SYM denotes –
T8319 4348-4350 NN denotes 2F
T8320 4350-4351 -RRB- denotes )
T8321 4351-4352 . denotes .
T8322 4352-4412 sentence denotes Growth of pelage hair was generally delayed in the mutants.
T8323 4353-4359 NN denotes Growth
T8325 4360-4362 IN denotes of
T8326 4363-4369 NN denotes pelage
T8327 4370-4374 NN denotes hair
T8328 4375-4378 VBD denotes was
T8329 4379-4388 RB denotes generally
T8324 4389-4396 VBN denotes delayed
T8330 4397-4399 IN denotes in
T8331 4400-4403 DT denotes the
T8332 4404-4411 NNS denotes mutants
T8333 4411-4412 . denotes .
T8334 4412-4567 sentence denotes At around P8, the KA mutants were hairless and had wrinkled skin while their phenotypically normal littermates had a smooth thin coat of hair (Figure 2B).
T8335 4413-4415 IN denotes At
T8337 4416-4422 RB denotes around
T8338 4423-4425 NN denotes P8
T8339 4425-4427 , denotes ,
T8340 4427-4430 DT denotes the
T8342 4431-4433 NN denotes KA
T8341 4434-4441 NNS denotes mutants
T8336 4442-4446 VBD denotes were
T8343 4447-4455 JJ denotes hairless
T8344 4456-4459 CC denotes and
T8345 4460-4463 VBD denotes had
T8346 4464-4472 VBN denotes wrinkled
T8347 4473-4477 NN denotes skin
T8348 4478-4483 IN denotes while
T8350 4484-4489 PRP$ denotes their
T8352 4490-4504 RB denotes phenotypically
T8353 4505-4511 JJ denotes normal
T8351 4512-4523 NNS denotes littermates
T8349 4524-4527 VBD denotes had
T8354 4528-4529 DT denotes a
T8356 4530-4536 JJ denotes smooth
T8357 4537-4541 JJ denotes thin
T8355 4542-4546 NN denotes coat
T8358 4547-4549 IN denotes of
T8359 4550-4554 NN denotes hair
T8360 4555-4556 -LRB- denotes (
T8362 4556-4562 NN denotes Figure
T8361 4563-4565 NN denotes 2B
T8363 4565-4566 -RRB- denotes )
T8364 4566-4567 . denotes .
T8365 4567-4696 sentence denotes At this age, two lower incisors start to erupt in normal littermates and these were absent in the KA mutants (Figure 2C and 2D).
T8366 4568-4570 IN denotes At
T8368 4571-4575 DT denotes this
T8369 4576-4579 NN denotes age
T8370 4579-4581 , denotes ,
T8371 4581-4584 CD denotes two
T8373 4585-4590 JJR denotes lower
T8372 4591-4599 NNS denotes incisors
T8367 4600-4605 VBP denotes start
T8374 4606-4608 TO denotes to
T8375 4609-4614 VB denotes erupt
T8376 4615-4617 IN denotes in
T8377 4618-4624 JJ denotes normal
T8378 4625-4636 NNS denotes littermates
T8379 4637-4640 CC denotes and
T8380 4641-4646 DT denotes these
T8381 4647-4651 VBD denotes were
T8382 4652-4658 JJ denotes absent
T8383 4659-4661 IN denotes in
T8384 4662-4665 DT denotes the
T8386 4666-4668 NN denotes KA
T8385 4669-4676 NNS denotes mutants
T8387 4677-4678 -LRB- denotes (
T8389 4678-4684 NN denotes Figure
T8388 4685-4687 NN denotes 2C
T8390 4688-4691 CC denotes and
T8391 4692-4694 NN denotes 2D
T8392 4694-4695 -RRB- denotes )
T8393 4695-4696 . denotes .
T8394 4696-4851 sentence denotes Animals also tended to be smaller and around P10–P12 displayed abnormally short and misshapen vibrissae and short, shaggy pelage hairs (Figure 2C and 2D).
T8395 4697-4704 NNS denotes Animals
T8397 4705-4709 RB denotes also
T8396 4710-4716 VBD denotes tended
T8398 4717-4719 TO denotes to
T8399 4720-4722 VB denotes be
T8400 4723-4730 JJR denotes smaller
T8401 4731-4734 CC denotes and
T8402 4735-4741 IN denotes around
T8404 4742-4745 NN denotes P10
T8405 4745-4746 SYM denotes –
T8406 4746-4749 NN denotes P12
T8403 4750-4759 VBD denotes displayed
T8407 4760-4770 RB denotes abnormally
T8408 4771-4776 JJ denotes short
T8410 4777-4780 CC denotes and
T8411 4781-4790 JJ denotes misshapen
T8409 4791-4800 NNS denotes vibrissae
T8412 4801-4804 CC denotes and
T8413 4805-4810 JJ denotes short
T8415 4810-4812 , denotes ,
T8416 4812-4818 JJ denotes shaggy
T8417 4819-4825 NN denotes pelage
T8414 4826-4831 NNS denotes hairs
T8418 4832-4833 -LRB- denotes (
T8420 4833-4839 NN denotes Figure
T8419 4840-4842 NN denotes 2C
T8421 4843-4846 CC denotes and
T8422 4847-4849 NN denotes 2D
T8423 4849-4850 -RRB- denotes )
T8424 4850-4851 . denotes .
T8425 4851-4990 sentence denotes Development of thick ridges in their skin, particularly around the ears, eyelids, forehead, nose, and paws, became noticeable (Figure 2E).
T8426 4852-4863 NN denotes Development
T8428 4864-4866 IN denotes of
T8429 4867-4872 JJ denotes thick
T8430 4873-4879 NNS denotes ridges
T8431 4880-4882 IN denotes in
T8432 4883-4888 PRP$ denotes their
T8433 4889-4893 NN denotes skin
T8434 4893-4895 , denotes ,
T8435 4895-4907 RB denotes particularly
T8436 4908-4914 IN denotes around
T8437 4915-4918 DT denotes the
T8438 4919-4923 NNS denotes ears
T8439 4923-4925 , denotes ,
T8440 4925-4932 NNS denotes eyelids
T8441 4932-4934 , denotes ,
T8442 4934-4942 NN denotes forehead
T8443 4942-4944 , denotes ,
T8444 4944-4948 NN denotes nose
T8445 4948-4950 , denotes ,
T8446 4950-4953 CC denotes and
T8447 4954-4958 NNS denotes paws
T8448 4958-4960 , denotes ,
T8427 4960-4966 VBD denotes became
T8449 4967-4977 JJ denotes noticeable
T8450 4978-4979 -LRB- denotes (
T8452 4979-4985 NN denotes Figure
T8451 4986-4988 NN denotes 2E
T8453 4988-4989 -RRB- denotes )
T8454 4989-4990 . denotes .
T8455 4990-5065 sentence denotes These regions looked scaly, and these animals hardly kept their eyes open.
T8456 4991-4996 DT denotes These
T8457 4997-5004 NNS denotes regions
T8458 5005-5011 VBD denotes looked
T8459 5012-5017 JJ denotes scaly
T8460 5017-5019 , denotes ,
T8461 5019-5022 CC denotes and
T8462 5023-5028 DT denotes these
T8463 5029-5036 NNS denotes animals
T8465 5037-5043 RB denotes hardly
T8464 5044-5048 VBD denotes kept
T8466 5049-5054 PRP$ denotes their
T8467 5055-5059 NNS denotes eyes
T8468 5060-5064 JJ denotes open
T8469 5064-5065 . denotes .
T8470 5065-5314 sentence denotes In contrast to the normal littermates that consistently increased their body weight with age, surviving KA mutants started to lose weight from P10 onwards; by P16–P17 they were all lethargic, and none of them survived to weaning (Figure 2E and 2F).
T8471 5066-5068 IN denotes In
T8473 5069-5077 NN denotes contrast
T8474 5078-5080 IN denotes to
T8475 5081-5084 DT denotes the
T8477 5085-5091 JJ denotes normal
T8476 5092-5103 NNS denotes littermates
T8478 5104-5108 WDT denotes that
T8480 5109-5121 RB denotes consistently
T8479 5122-5131 VBD denotes increased
T8481 5132-5137 PRP$ denotes their
T8483 5138-5142 NN denotes body
T8482 5143-5149 NN denotes weight
T8484 5150-5154 IN denotes with
T8485 5155-5158 NN denotes age
T8486 5158-5160 , denotes ,
T8487 5160-5169 VBG denotes surviving
T8489 5170-5172 NN denotes KA
T8488 5173-5180 NNS denotes mutants
T8472 5181-5188 VBD denotes started
T8491 5189-5191 TO denotes to
T8492 5192-5196 VB denotes lose
T8493 5197-5203 NN denotes weight
T8494 5204-5208 IN denotes from
T8495 5209-5212 NN denotes P10
T8496 5213-5220 RB denotes onwards
T8497 5220-5221 : denotes ;
T8498 5222-5224 IN denotes by
T8499 5225-5228 NN denotes P16
T8500 5228-5229 SYM denotes –
T8501 5229-5232 NN denotes P17
T8502 5233-5237 PRP denotes they
T8490 5238-5242 VBD denotes were
T8503 5243-5246 RB denotes all
T8504 5247-5256 JJ denotes lethargic
T8505 5256-5258 , denotes ,
T8506 5258-5261 CC denotes and
T8507 5262-5266 NN denotes none
T8509 5267-5269 IN denotes of
T8510 5270-5274 PRP denotes them
T8508 5275-5283 VBD denotes survived
T8511 5284-5286 IN denotes to
T8512 5287-5294 NN denotes weaning
T8513 5295-5296 -LRB- denotes (
T8515 5296-5302 NN denotes Figure
T8514 5303-5305 NN denotes 2E
T8516 5306-5309 CC denotes and
T8517 5310-5312 NN denotes 2F
T8518 5312-5313 -RRB- denotes )
T8519 5313-5314 . denotes .
T8520 5314-5607 sentence denotes At the time of autopsy all the mutants were toothless, without incisors or molars, and their stomachs were consistently small and had no solid food, unlike their age-matched littermates, suggesting that the observed weight loss could be the result of failure to ingest solid food (Figure 2F).
T8521 5315-5317 IN denotes At
T8523 5318-5321 DT denotes the
T8524 5322-5326 NN denotes time
T8525 5327-5329 IN denotes of
T8526 5330-5337 NN denotes autopsy
T8527 5338-5341 PDT denotes all
T8529 5342-5345 DT denotes the
T8528 5346-5353 NNS denotes mutants
T8522 5354-5358 VBD denotes were
T8530 5359-5368 JJ denotes toothless
T8531 5368-5370 , denotes ,
T8532 5370-5377 IN denotes without
T8533 5378-5386 NNS denotes incisors
T8534 5387-5389 CC denotes or
T8535 5390-5396 NNS denotes molars
T8536 5396-5398 , denotes ,
T8537 5398-5401 CC denotes and
T8538 5402-5407 PRP$ denotes their
T8539 5408-5416 NNS denotes stomachs
T8540 5417-5421 VBD denotes were
T8541 5422-5434 RB denotes consistently
T8542 5435-5440 JJ denotes small
T8543 5441-5444 CC denotes and
T8544 5445-5448 VBD denotes had
T8545 5449-5451 DT denotes no
T8547 5452-5457 JJ denotes solid
T8546 5458-5462 NN denotes food
T8548 5462-5464 , denotes ,
T8549 5464-5470 IN denotes unlike
T8550 5471-5476 PRP$ denotes their
T8552 5477-5480 NN denotes age
T8554 5480-5481 HYPH denotes -
T8553 5481-5488 JJ denotes matched
T8551 5489-5500 NNS denotes littermates
T8555 5500-5502 , denotes ,
T8556 5502-5512 VBG denotes suggesting
T8557 5513-5517 IN denotes that
T8559 5518-5521 DT denotes the
T8561 5522-5530 VBN denotes observed
T8562 5531-5537 NN denotes weight
T8560 5538-5542 NN denotes loss
T8563 5543-5548 MD denotes could
T8558 5549-5551 VB denotes be
T8564 5552-5555 DT denotes the
T8565 5556-5562 NN denotes result
T8566 5563-5565 IN denotes of
T8567 5566-5573 NN denotes failure
T8568 5574-5576 TO denotes to
T8569 5577-5583 VB denotes ingest
T8570 5584-5589 JJ denotes solid
T8571 5590-5594 NN denotes food
T8572 5595-5596 -LRB- denotes (
T8574 5596-5602 NN denotes Figure
T8573 5603-5605 NN denotes 2F
T8575 5605-5606 -RRB- denotes )
T8576 5606-5607 . denotes .
T8577 5607-5823 sentence denotes Interestingly, changes in body weights and timing of hair growth varied considerably among mutant pups even if they were from the same litter, whereas those of phenotypically normal littermates tended to be similar.
T8578 5608-5621 RB denotes Interestingly
T8580 5621-5623 , denotes ,
T8581 5623-5630 NNS denotes changes
T8582 5631-5633 IN denotes in
T8583 5634-5638 NN denotes body
T8584 5639-5646 NNS denotes weights
T8585 5647-5650 CC denotes and
T8586 5651-5657 NN denotes timing
T8587 5658-5660 IN denotes of
T8588 5661-5665 NN denotes hair
T8589 5666-5672 NN denotes growth
T8579 5673-5679 VBD denotes varied
T8590 5680-5692 RB denotes considerably
T8591 5693-5698 IN denotes among
T8592 5699-5705 JJ denotes mutant
T8593 5706-5710 NNS denotes pups
T8594 5711-5715 RB denotes even
T8596 5716-5718 IN denotes if
T8597 5719-5723 PRP denotes they
T8595 5724-5728 VBD denotes were
T8598 5729-5733 IN denotes from
T8599 5734-5737 DT denotes the
T8601 5738-5742 JJ denotes same
T8600 5743-5749 NN denotes litter
T8602 5749-5751 , denotes ,
T8603 5751-5758 IN denotes whereas
T8605 5759-5764 DT denotes those
T8606 5765-5767 IN denotes of
T8607 5768-5782 RB denotes phenotypically
T8608 5783-5789 JJ denotes normal
T8609 5790-5801 NNS denotes littermates
T8604 5802-5808 VBD denotes tended
T8610 5809-5811 TO denotes to
T8611 5812-5814 VB denotes be
T8612 5815-5822 JJ denotes similar
T8613 5822-5823 . denotes .
T8614 5823-6009 sentence denotes This difference was also reflected in the variation in timing of death in mutants: some mutant pups were born alive but died within a day or two, some survived close to the weaning age.
T8615 5824-5828 DT denotes This
T8616 5829-5839 NN denotes difference
T8618 5840-5843 VBD denotes was
T8619 5844-5848 RB denotes also
T8617 5849-5858 VBN denotes reflected
T8621 5859-5861 IN denotes in
T8622 5862-5865 DT denotes the
T8623 5866-5875 NN denotes variation
T8624 5876-5878 IN denotes in
T8625 5879-5885 NN denotes timing
T8626 5886-5888 IN denotes of
T8627 5889-5894 NN denotes death
T8628 5895-5897 IN denotes in
T8629 5898-5905 NNS denotes mutants
T8630 5905-5907 : denotes :
T8631 5907-5911 DT denotes some
T8633 5912-5918 JJ denotes mutant
T8632 5919-5923 NNS denotes pups
T8635 5924-5928 VBD denotes were
T8634 5929-5933 VBN denotes born
T8636 5934-5939 JJ denotes alive
T8637 5940-5943 CC denotes but
T8638 5944-5948 VBD denotes died
T8639 5949-5955 IN denotes within
T8640 5956-5957 DT denotes a
T8641 5958-5961 NN denotes day
T8642 5962-5964 CC denotes or
T8643 5965-5968 CD denotes two
T8644 5968-5970 , denotes ,
T8645 5970-5974 DT denotes some
T8620 5975-5983 VBD denotes survived
T8646 5984-5989 RB denotes close
T8647 5990-5992 IN denotes to
T8648 5993-5996 DT denotes the
T8650 5997-6004 JJ denotes weaning
T8649 6005-6008 NN denotes age
T8651 6008-6009 . denotes .
T8652 6009-6138 sentence denotes This variability of the mutant phenotypes suggests possible variation in the timing and efficiency of cre-mediated Apc deletion.
T8653 6010-6014 DT denotes This
T8654 6015-6026 NN denotes variability
T8656 6027-6029 IN denotes of
T8657 6030-6033 DT denotes the
T8659 6034-6040 JJ denotes mutant
T8658 6041-6051 NNS denotes phenotypes
T8655 6052-6060 VBZ denotes suggests
T8660 6061-6069 JJ denotes possible
T8661 6070-6079 NN denotes variation
T8662 6080-6082 IN denotes in
T8663 6083-6086 DT denotes the
T8664 6087-6093 NN denotes timing
T8665 6094-6097 CC denotes and
T8666 6098-6108 NN denotes efficiency
T8667 6109-6111 IN denotes of
T8668 6112-6115 NN denotes cre
T8670 6115-6116 HYPH denotes -
T8669 6116-6124 JJ denotes mediated
T8672 6125-6128 NN denotes Apc
T8671 6129-6137 NN denotes deletion
T8673 6137-6138 . denotes .
T8674 6138-6221 sentence denotes It is possible that the genetic background has a role to play in this variability.
T8675 6139-6141 PRP denotes It
T8676 6142-6144 VBZ denotes is
T8677 6145-6153 JJ denotes possible
T8678 6154-6158 IN denotes that
T8680 6159-6162 DT denotes the
T8682 6163-6170 JJ denotes genetic
T8681 6171-6181 NN denotes background
T8679 6182-6185 VBZ denotes has
T8683 6186-6187 DT denotes a
T8684 6188-6192 NN denotes role
T8685 6193-6195 TO denotes to
T8686 6196-6200 VB denotes play
T8687 6201-6203 IN denotes in
T8688 6204-6208 DT denotes this
T8689 6209-6220 NN denotes variability
T8690 6220-6221 . denotes .
T8691 6221-6437 sentence denotes Gross examination of internal organs also showed that the mutants' thymi were consistently inconspicuous and were very small for their age, whereas those of their littermates were very prominent in size (Figure 2G).
T8692 6222-6227 JJ denotes Gross
T8693 6228-6239 NN denotes examination
T8695 6240-6242 IN denotes of
T8696 6243-6251 JJ denotes internal
T8697 6252-6258 NNS denotes organs
T8698 6259-6263 RB denotes also
T8694 6264-6270 VBD denotes showed
T8699 6271-6275 IN denotes that
T8701 6276-6279 DT denotes the
T8702 6280-6287 NNS denotes mutants
T8704 6287-6288 POS denotes '
T8703 6289-6294 NNS denotes thymi
T8700 6295-6299 VBD denotes were
T8705 6300-6312 RB denotes consistently
T8706 6313-6326 JJ denotes inconspicuous
T8707 6327-6330 CC denotes and
T8708 6331-6335 VBD denotes were
T8709 6336-6340 RB denotes very
T8710 6341-6346 JJ denotes small
T8711 6347-6350 IN denotes for
T8712 6351-6356 PRP$ denotes their
T8713 6357-6360 NN denotes age
T8714 6360-6362 , denotes ,
T8715 6362-6369 IN denotes whereas
T8717 6370-6375 DT denotes those
T8718 6376-6378 IN denotes of
T8719 6379-6384 PRP$ denotes their
T8720 6385-6396 NNS denotes littermates
T8716 6397-6401 VBD denotes were
T8721 6402-6406 RB denotes very
T8722 6407-6416 JJ denotes prominent
T8723 6417-6419 IN denotes in
T8724 6420-6424 NN denotes size
T8725 6425-6426 -LRB- denotes (
T8727 6426-6432 NN denotes Figure
T8726 6433-6435 NN denotes 2G
T8728 6435-6436 -RRB- denotes )
T8729 6436-6437 . denotes .
T8730 6437-6481 sentence denotes This difference was evident as early as P3.
T8731 6438-6442 DT denotes This
T8732 6443-6453 NN denotes difference
T8733 6454-6457 VBD denotes was
T8734 6458-6465 JJ denotes evident
T8735 6466-6468 RB denotes as
T8736 6469-6474 RB denotes early
T8737 6475-6477 IN denotes as
T8738 6478-6480 NN denotes P3
T8739 6480-6481 . denotes .
T8740 6481-6602 sentence denotes Quite frequently mutant thymi in P12–P17 mutant mice also contained black deposits within the tissue (unpublished data).
T8741 6482-6487 RB denotes Quite
T8742 6488-6498 RB denotes frequently
T8744 6499-6505 JJ denotes mutant
T8745 6506-6511 NNS denotes thymi
T8746 6512-6514 IN denotes in
T8747 6515-6518 NN denotes P12
T8749 6518-6519 SYM denotes –
T8750 6519-6522 NN denotes P17
T8751 6523-6529 JJ denotes mutant
T8748 6530-6534 NNS denotes mice
T8752 6535-6539 RB denotes also
T8743 6540-6549 VBD denotes contained
T8753 6550-6555 JJ denotes black
T8754 6556-6564 NNS denotes deposits
T8755 6565-6571 IN denotes within
T8756 6572-6575 DT denotes the
T8757 6576-6582 NN denotes tissue
T8758 6583-6584 -LRB- denotes (
T8760 6584-6595 JJ denotes unpublished
T8759 6596-6600 NNS denotes data
T8761 6600-6601 -RRB- denotes )
T8762 6601-6602 . denotes .
T8763 6602-6739 sentence denotes Mutant mice were also examined for any skeletal abnormalities by preparing skeletal specimens of P16–P17 mice stained with Alizarin red.
T8764 6603-6609 JJ denotes Mutant
T8765 6610-6614 NNS denotes mice
T8767 6615-6619 VBD denotes were
T8768 6620-6624 RB denotes also
T8766 6625-6633 VBN denotes examined
T8769 6634-6637 IN denotes for
T8770 6638-6641 DT denotes any
T8772 6642-6650 JJ denotes skeletal
T8771 6651-6664 NNS denotes abnormalities
T8773 6665-6667 IN denotes by
T8774 6668-6677 VBG denotes preparing
T8775 6678-6686 JJ denotes skeletal
T8776 6687-6696 NNS denotes specimens
T8777 6697-6699 IN denotes of
T8778 6700-6703 NN denotes P16
T8780 6703-6704 SYM denotes –
T8781 6704-6707 NN denotes P17
T8779 6708-6712 NNS denotes mice
T8782 6713-6720 VBN denotes stained
T8783 6721-6725 IN denotes with
T8784 6726-6734 NN denotes Alizarin
T8785 6735-6738 NN denotes red
T8786 6738-6739 . denotes .
T8787 6739-6931 sentence denotes No differences between the normal and KA mutant mice in the mandibular bone can be detected, but the mutant mice lacked or had underdeveloped set of maxillary incisors and molars (Figure 2H).
T8788 6740-6742 DT denotes No
T8789 6743-6754 NNS denotes differences
T8791 6755-6762 IN denotes between
T8792 6763-6766 DT denotes the
T8794 6767-6773 JJ denotes normal
T8795 6774-6777 CC denotes and
T8796 6778-6780 NN denotes KA
T8797 6781-6787 JJ denotes mutant
T8793 6788-6792 NNS denotes mice
T8798 6793-6795 IN denotes in
T8799 6796-6799 DT denotes the
T8801 6800-6810 JJ denotes mandibular
T8800 6811-6815 NN denotes bone
T8802 6816-6819 MD denotes can
T8803 6820-6822 VB denotes be
T8790 6823-6831 VBN denotes detected
T8804 6831-6833 , denotes ,
T8805 6833-6836 CC denotes but
T8806 6837-6840 DT denotes the
T8808 6841-6847 JJ denotes mutant
T8807 6848-6852 NNS denotes mice
T8809 6853-6859 VBD denotes lacked
T8810 6860-6862 CC denotes or
T8811 6863-6866 VBD denotes had
T8812 6867-6881 VBN denotes underdeveloped
T8813 6882-6885 NN denotes set
T8814 6886-6888 IN denotes of
T8815 6889-6898 JJ denotes maxillary
T8816 6899-6907 NNS denotes incisors
T8817 6908-6911 CC denotes and
T8818 6912-6918 NNS denotes molars
T8819 6919-6920 -LRB- denotes (
T8821 6920-6926 NN denotes Figure
T8820 6927-6929 NN denotes 2H
T8822 6929-6930 -RRB- denotes )
T8823 6930-6931 . denotes .
T8824 6931-6982 sentence denotes We detected no other major skeletal abnormalities.
T8825 6932-6934 PRP denotes We
T8826 6935-6943 VBD denotes detected
T8827 6944-6946 DT denotes no
T8829 6947-6952 JJ denotes other
T8830 6953-6958 JJ denotes major
T8831 6959-6967 JJ denotes skeletal
T8828 6968-6981 NNS denotes abnormalities
T8832 6981-6982 . denotes .
R1595 T7674 T7675 npadvmod K14,Driven
R1596 T7675 T7677 amod Driven,Loss
R1597 T7676 T7675 punct -,Driven
R1598 T7677 T7678 nsubj Loss,Results
R1599 T7679 T7677 prep of,Loss
R1600 T7680 T7679 pobj Apc,of
R1601 T7681 T7678 prep in,Results
R1602 T7682 T7683 amod Severe,Retardation
R1603 T7683 T7681 pobj Retardation,in
R1604 T7684 T7683 compound Growth,Retardation
R1605 T7685 T7683 cc and,Retardation
R1606 T7686 T7687 amod Early,Lethality
R1607 T7687 T7683 conj Lethality,Retardation
R1608 T7689 T7690 aux To,introduce
R1609 T7690 T7691 advcl introduce,crossed
R1610 T7692 T7693 det the,mutation
R1611 T7693 T7690 dobj mutation,introduce
R1612 T7694 T7693 prep of,mutation
R1613 T7695 T7694 pobj Apc,of
R1614 T7696 T7690 prep into,introduce
R1615 T7697 T7696 pobj cells,into
R1616 T7698 T7697 acl expressing,cells
R1617 T7699 T7698 dobj K14,expressing
R1618 T7700 T7691 punct ", ",crossed
R1619 T7701 T7691 nsubj we,crossed
R1620 T7702 T7703 nmod WW6,mice
R1621 T7703 T7691 dobj mice,crossed
R1622 T7704 T7705 compound ES,cell
R1623 T7705 T7706 npadvmod cell,derived
R1624 T7706 T7703 amod derived,mice
R1625 T7707 T7706 punct –,derived
R1626 T7708 T7709 punct [,15
R1627 T7709 T7706 parataxis 15,derived
R1628 T7710 T7709 punct ],15
R1629 T7711 T7703 nmod ApcCKO,mice
R1630 T7712 T7711 punct /,ApcCKO
R1631 T7713 T7711 punct +,ApcCKO
R1632 T7714 T7703 prep with,mice
R1633 T7715 T7716 compound K14,cre
R1634 T7716 T7718 compound cre,mice
R1635 T7717 T7716 punct -,cre
R1636 T7718 T7714 pobj mice,with
R1637 T7719 T7718 compound recombinase,mice
R1638 T7720 T7703 prep in,mice
R1639 T7721 T7722 compound FVB,background
R1640 T7722 T7720 pobj background,in
R1641 T7723 T7724 punct [,16
R1642 T7724 T7691 parataxis 16,crossed
R1643 T7725 T7724 punct ],16
R1644 T7726 T7691 punct .,crossed
R1645 T7728 T7729 det The,mice
R1646 T7729 T7737 nsubj mice,were
R1647 T7730 T7731 nmod K14,cre
R1648 T7731 T7729 nmod cre,mice
R1649 T7732 T7731 punct -,cre
R1650 T7733 T7731 punct ;,cre
R1651 T7734 T7731 appos ApcCKO,cre
R1652 T7735 T7734 punct /,ApcCKO
R1653 T7736 T7734 punct +,ApcCKO
R1654 T7738 T7737 acomp normal,were
R1655 T7739 T7737 prep in,were
R1656 T7740 T7739 pobj appearance,in
R1657 T7741 T7737 cc and,were
R1658 T7742 T7737 conj were,were
R1659 T7743 T7742 acomp fertile,were
R1660 T7744 T7737 punct .,were
R1661 T7746 T7747 nmod K14,cre
R1662 T7747 T7749 nmod cre,males
R1663 T7748 T7747 punct -,cre
R1664 T7749 T7754 nsubjpass males,crossed
R1665 T7750 T7747 punct ;,cre
R1666 T7751 T7747 appos ApcCKO,cre
R1667 T7752 T7751 punct /,ApcCKO
R1668 T7753 T7751 punct +,ApcCKO
R1669 T7755 T7754 auxpass were,crossed
R1670 T7756 T7754 prep to,crossed
R1671 T7757 T7758 compound ApcCKO,CKO
R1672 T7758 T7760 compound CKO,females
R1673 T7759 T7758 punct /,CKO
R1674 T7760 T7756 pobj females,to
R1675 T7761 T7762 aux to,avoid
R1676 T7762 T7754 advcl avoid,crossed
R1677 T7763 T7764 det the,effect
R1678 T7764 T7762 dobj effect,avoid
R1679 T7765 T7764 amod potential,effect
R1680 T7766 T7764 compound deleter,effect
R1681 T7767 T7762 prep in,avoid
R1682 T7768 T7767 pobj oocytes,in
R1683 T7769 T7768 prep of,oocytes
R1684 T7770 T7771 compound K14,cre
R1685 T7771 T7773 npadvmod cre,positive
R1686 T7772 T7771 punct -,cre
R1687 T7773 T7775 amod positive,females
R1688 T7774 T7773 punct –,positive
R1689 T7775 T7769 pobj females,of
R1690 T7776 T7777 punct [,17
R1691 T7777 T7754 parataxis 17,crossed
R1692 T7778 T7777 punct ],17
R1693 T7779 T7754 punct .,crossed
R1694 T7781 T7782 det The,mice
R1695 T7782 T7783 nsubjpass mice,intercrossed
R1696 T7783 T7785 ccomp intercrossed,were
R1697 T7784 T7783 auxpass were,intercrossed
R1698 T7786 T7783 advmod thereafter,intercrossed
R1699 T7787 T7783 prep for,intercrossed
R1700 T7788 T7787 pobj maintenance,for
R1701 T7789 T7785 punct ;,were
R1702 T7790 T7785 advmod hence,were
R1703 T7791 T7785 punct ", ",were
R1704 T7792 T7793 det the,mice
R1705 T7793 T7785 nsubj mice,were
R1706 T7794 T7793 acl used,mice
R1707 T7795 T7794 prep for,used
R1708 T7796 T7795 pobj analysis,for
R1709 T7797 T7785 prep in,were
R1710 T7798 T7799 det a,background
R1711 T7799 T7797 pobj background,in
R1712 T7800 T7799 amod mixed,background
R1713 T7801 T7799 prep of,background
R1714 T7802 T7801 pobj FVB,of
R1715 T7803 T7802 punct ", ",FVB
R1716 T7804 T7805 nummod 129,S
R1717 T7805 T7802 conj S,FVB
R1718 T7806 T7805 punct /,S
R1719 T7807 T7805 punct ", ",S
R1720 T7808 T7805 cc and,S
R1721 T7809 T7805 conj C57BL,S
R1722 T7810 T7809 punct /,C57BL
R1723 T7811 T7809 nummod 6,C57BL
R1724 T7812 T7802 prep in,FVB
R1725 T7813 T7814 amod similar,proportions
R1726 T7814 T7812 pobj proportions,in
R1727 T7815 T7802 punct ", ",FVB
R1728 T7816 T7802 prep with,FVB
R1729 T7817 T7818 amod minimal,contribution
R1730 T7818 T7816 pobj contribution,with
R1731 T7819 T7818 prep of,contribution
R1732 T7820 T7819 pobj SJ,of
R1733 T7821 T7785 punct .,were
R1734 T7824 T7826 nsubj promoter,is
R1735 T7823 T7824 det The,promoter
R1736 T7825 T7824 compound K14,promoter
R1737 T7929 T7928 pobj crosses,from
R1738 T7827 T7828 det a,promoter
R1739 T7930 T7929 prep between,crosses
R1740 T7828 T7826 attr promoter,is
R1741 T7829 T7830 advmod commonly,used
R1742 T7830 T7828 amod used,promoter
R1743 T7831 T7832 amod epidermal,cell
R1744 T7832 T7828 compound cell,promoter
R1745 T7833 T7826 prep because,is
R1746 T7931 T7932 nmod K14,cre
R1747 T7834 T7833 pcomp of,because
R1748 T7835 T7836 poss its,expression
R1749 T7836 T7833 pobj expression,because
R1750 T7932 T7934 nmod cre,mice
R1751 T7837 T7836 prep by,expression
R1752 T7838 T7839 det the,cells
R1753 T7839 T7837 pobj cells,by
R1754 T7933 T7932 punct -,cre
R1755 T7840 T7841 advmod mitotically,active
R1756 T7841 T7839 amod active,cells
R1757 T7842 T7839 prep of,cells
R1758 T7934 T7930 pobj mice,between
R1759 T7843 T7844 det the,epidermis
R1760 T7844 T7842 pobj epidermis,of
R1761 T7845 T7844 cc and,epidermis
R1762 T7846 T7847 poss its,appendages
R1763 T7847 T7844 conj appendages,epidermis
R1764 T7848 T7836 prep in,expression
R1765 T7935 T7932 punct ;,cre
R1766 T7849 T7850 amod mature,skin
R1767 T7850 T7848 pobj skin,in
R1768 T7851 T7852 punct [,18
R1769 T7936 T7932 appos ApcCKO,cre
R1770 T7852 T7836 parataxis 18,expression
R1771 T7853 T7852 punct ],18
R1772 T7937 T7936 punct /,ApcCKO
R1773 T7938 T7936 punct +,ApcCKO
R1774 T7854 T7826 punct ", ",is
R1775 T7939 T7932 cc and,cre
R1776 T7855 T7826 cc but,is
R1777 T7856 T7857 advmod most,notably
R1778 T7857 T7858 advmod notably,is
R1779 T7858 T7826 conj is,is
R1780 T7940 T7941 compound ApcCKO,CKO
R1781 T7859 T7858 nsubj it,is
R1782 T7860 T7858 acomp active,is
R1783 T7941 T7932 conj CKO,cre
R1784 T7861 T7858 prep in,is
R1785 T7862 T7863 amod embryonic,ectoderm
R1786 T7942 T7941 punct /,CKO
R1787 T7863 T7861 pobj ectoderm,in
R1788 T7864 T7865 advmod as,early
R1789 T7865 T7858 advmod early,is
R1790 T7943 T7911 punct .,genotyped
R1791 T7866 T7865 prep as,early
R1792 T7867 T7868 det the,stage
R1793 T7868 T7866 pobj stage,as
R1794 T7945 T7946 det The,mice
R1795 T7869 T7870 amod single,layered
R1796 T7870 T7868 amod layered,stage
R1797 T7871 T7868 amod ectodermal,stage
R1798 T7872 T7868 prep of,stage
R1799 T7873 T7874 amod embryonic,day
R1800 T7874 T7872 pobj day,of
R1801 T7875 T7876 punct (,E
R1802 T7946 T7948 nsubjpass mice,born
R1803 T7876 T7874 parataxis E,day
R1804 T7877 T7876 punct ),E
R1805 T7878 T7874 nummod 9.5,day
R1806 T7879 T7880 punct [,19
R1807 T7947 T7946 amod mutant,mice
R1808 T7880 T7858 parataxis 19,is
R1809 T7881 T7880 punct ],19
R1810 T7949 T7946 prep of,mice
R1811 T7882 T7858 punct .,is
R1812 T7884 T7885 det A,expression
R1813 T7885 T7887 nsubjpass expression,found
R1814 T7886 T7885 amod restricted,expression
R1815 T7950 T7951 det the,genotype
R1816 T7888 T7885 prep of,expression
R1817 T7889 T7888 pobj K14,of
R1818 T7890 T7887 auxpass is,found
R1819 T7951 T7949 pobj genotype,of
R1820 T7891 T7887 advmod also,found
R1821 T7892 T7887 prep in,found
R1822 T7893 T7894 amod thymic,cells
R1823 T7952 T7953 compound K14,cre
R1824 T7894 T7892 pobj cells,in
R1825 T7895 T7894 amod epithelial,cells
R1826 T7953 T7951 appos cre,genotype
R1827 T7896 T7894 punct (,cells
R1828 T7897 T7894 appos TECs,cells
R1829 T7898 T7887 punct ),found
R1830 T7954 T7953 punct -,cre
R1831 T7899 T7887 prep in,found
R1832 T7900 T7901 det the,medulla
R1833 T7901 T7899 pobj medulla,in
R1834 T7902 T7901 prep of,medulla
R1835 T7955 T7953 punct ;,cre
R1836 T7903 T7904 amod normal,thymus
R1837 T7904 T7902 pobj thymus,of
R1838 T7905 T7906 punct [,20
R1839 T7956 T7957 compound ApcCKO,CKO
R1840 T7906 T7887 parataxis 20,found
R1841 T7907 T7906 punct ],20
R1842 T7908 T7887 punct .,found
R1843 T7957 T7953 appos CKO,cre
R1844 T7910 T7911 nsubj We,genotyped
R1845 T7958 T7957 punct /,CKO
R1846 T7912 T7913 quantmod a,458
R1847 T7913 T7916 nummod 458,pups
R1848 T7914 T7913 quantmod total,458
R1849 T7915 T7913 quantmod of,458
R1850 T7916 T7911 dobj pups,genotyped
R1851 T7959 T7960 punct (,mutant
R1852 T7917 T7918 punct (,old
R1853 T7918 T7916 parataxis old,pups
R1854 T7919 T7920 quantmod 8,10
R1855 T7920 T7922 nummod 10,d
R1856 T7960 T7946 parataxis mutant,mice
R1857 T7921 T7920 punct –,10
R1858 T7922 T7918 npadvmod d,old
R1859 T7923 T7918 punct ),old
R1860 T7961 T7960 advmod hereafter,mutant
R1861 T7924 T7916 prep from,pups
R1862 T7925 T7926 nummod 67,litters
R1863 T7926 T7924 pobj litters,from
R1864 T7962 T7960 punct ", ",mutant
R1865 T7927 T7926 acl resulting,litters
R1866 T7928 T7927 prep from,resulting
R1867 T7963 T7960 compound KA,mutant
R1868 T7964 T7960 punct ),mutant
R1869 T7965 T7948 auxpass were,born
R1870 T7966 T7948 punct ", ",born
R1871 T7967 T7948 cc but,born
R1872 T7968 T7969 det the,frequency
R1873 T8034 T8037 nummod 25,pups
R1874 T7969 T7971 nsubj frequency,was
R1875 T8035 T8034 quantmod total,25
R1876 T8036 T8034 quantmod of,25
R1877 T7970 T7969 amod observed,frequency
R1878 T8037 T8038 nsubjpass pups,born
R1879 T8039 T8038 auxpass were,born
R1880 T7971 T7948 conj was,born
R1881 T8040 T8038 prep from,born
R1882 T8041 T8042 nummod three,litters
R1883 T7972 T7969 prep of,frequency
R1884 T8042 T8040 pobj litters,from
R1885 T8043 T8042 punct ", ",litters
R1886 T8044 T8045 prep of,confirmed
R1887 T7973 T7974 compound KA,mutants
R1888 T8045 T8042 relcl confirmed,litters
R1889 T8046 T8044 pobj which,of
R1890 T8047 T8045 nsubjpass 7,confirmed
R1891 T7974 T7972 pobj mutants,of
R1892 T8048 T8049 punct (,%
R1893 T8049 T8047 parataxis %,7
R1894 T7975 T7976 advmod much,less
R1895 T8050 T8049 nummod 28,%
R1896 T8051 T8049 punct ),%
R1897 T8052 T8045 auxpass were,confirmed
R1898 T8053 T8054 aux to,be
R1899 T8054 T8045 xcomp be,confirmed
R1900 T8055 T8056 compound K14,cre
R1901 T8056 T8054 attr cre,be
R1902 T7976 T7971 acomp less,was
R1903 T8057 T8056 punct -,cre
R1904 T8058 T8056 punct ;,cre
R1905 T8059 T8060 compound ApcCKO,CKO
R1906 T7977 T7978 mark than,expected
R1907 T8060 T8056 appos CKO,cre
R1908 T8061 T8060 punct /,CKO
R1909 T8062 T8045 prep by,confirmed
R1910 T7978 T7976 advcl expected,less
R1911 T8063 T8062 pobj genotyping,by
R1912 T8064 T8045 punct ", ",confirmed
R1913 T7979 T7980 punct (,Table
R1914 T8065 T8045 advcl indicating,confirmed
R1915 T8066 T8067 mark that,born
R1916 T8067 T8065 ccomp born,indicating
R1917 T7980 T7976 parataxis Table,less
R1918 T8068 T8069 compound KA,mutants
R1919 T8069 T8067 nsubjpass mutants,born
R1920 T8070 T8067 auxpass were,born
R1921 T7981 T7980 dep 78,Table
R1922 T8071 T8067 prep in,born
R1923 T8072 T8073 det the,ratio
R1924 T8073 T8071 pobj ratio,in
R1925 T7982 T7981 prep of,78
R1926 T8074 T8073 amod expected,ratio
R1927 T8075 T8073 amod Mendelian,ratio
R1928 T7983 T7982 pobj 458,of
R1929 T8076 T8038 punct .,born
R1930 T8078 T8079 det The,pups
R1931 T7984 T7985 punct [,%
R1932 T8079 T8082 nsubjpass pups,nursed
R1933 T8080 T8079 nmod KA,pups
R1934 T8081 T8079 amod mutant,pups
R1935 T7985 T7981 parataxis %,78
R1936 T8083 T8082 auxpass were,nursed
R1937 T7986 T7985 nummod 17.0,%
R1938 T8084 T8082 advmod normally,nursed
R1939 T8085 T8082 punct ", ",nursed
R1940 T8086 T8082 cc and,nursed
R1941 T7987 T7985 punct ],%
R1942 T8087 T8088 expl there,was
R1943 T8088 T8082 conj was,nursed
R1944 T8089 T8088 attr milk,was
R1945 T7988 T7980 punct ;,Table
R1946 T8090 T8088 prep in,was
R1947 T8091 T8092 poss their,stomachs
R1948 T7989 T7990 nsubj p,analysis
R1949 T8092 T8090 pobj stomachs,in
R1950 T8093 T8088 prep during,was
R1951 T8094 T8095 det the,d
R1952 T8095 T8093 pobj d,during
R1953 T8096 T8095 amod first,d
R1954 T8097 T8095 nummod 2,d
R1955 T8098 T8097 cc or,2
R1956 T7990 T7980 ccomp analysis,Table
R1957 T8099 T8097 conj 3,2
R1958 T8100 T8095 prep after,d
R1959 T8101 T8100 pobj birth,after
R1960 T7991 T7990 punct <,analysis
R1961 T8102 T8082 punct ", ",nursed
R1962 T8103 T8082 cc but,nursed
R1963 T8104 T8105 nsubj they,failed
R1964 T7992 T7990 nummod 0.0005,analysis
R1965 T8105 T8082 conj failed,nursed
R1966 T7993 T7994 compound Chi,square
R1967 T8106 T8107 aux to,thrive
R1968 T8107 T8105 xcomp thrive,failed
R1969 T7994 T7990 compound square,analysis
R1970 T8108 T8109 punct (,Figure
R1971 T8109 T8107 parataxis Figure,thrive
R1972 T8110 T8109 nummod 2,Figure
R1973 T7995 T7994 punct -,square
R1974 T8111 T8109 punct ),Figure
R1975 T8112 T8105 punct .,failed
R1976 T7996 T7980 punct ", ",Table
R1977 T8114 T8115 prep By,were
R1978 T7997 T7980 nummod 1,Table
R1979 T8116 T8117 amod postnatal,day
R1980 T8117 T8114 pobj day,By
R1981 T7998 T7980 punct ),Table
R1982 T8118 T8117 punct (,day
R1983 T8119 T8117 appos P,day
R1984 T7999 T7971 punct .,was
R1985 T8120 T8117 punct ),day
R1986 T8121 T8117 appos 8,day
R1987 T8122 T8123 punct –,10
R1988 T8001 T8002 aux To,assess
R1989 T8123 T8121 prep 10,8
R1990 T8124 T8115 punct ", ",were
R1991 T8125 T8115 prep at,were
R1992 T8002 T8003 advcl assess,monitored
R1993 T8126 T8127 det the,time
R1994 T8127 T8125 pobj time,at
R1995 T8128 T8127 prep of,time
R1996 T8129 T8128 pobj genotyping,of
R1997 T8004 T8005 det the,basis
R1998 T8130 T8115 punct ", ",were
R1999 T8131 T8132 amod many,pups
R2000 T8005 T8002 dobj basis,assess
R2001 T8132 T8115 nsubj pups,were
R2002 T8133 T8132 nmod KA,pups
R2003 T8134 T8132 amod mutant,pups
R2004 T8135 T8136 advmod considerably,smaller
R2005 T8006 T8005 prep for,basis
R2006 T8136 T8115 acomp smaller,were
R2007 T8137 T8136 prep than,smaller
R2008 T8138 T8139 poss their,littermates
R2009 T8007 T8008 det the,lethality
R2010 T8139 T8137 pobj littermates,than
R2011 T8008 T8006 pobj lethality,for
R2012 T8009 T8008 amod neonatal,lethality
R2013 T8010 T8008 prep of,lethality
R2014 T8140 T8141 punct (,2B
R2015 T8141 T8115 parataxis 2B,were
R2016 T8011 T8012 compound KA,mutants
R2017 T8142 T8141 compound Figure,2B
R2018 T8143 T8144 punct –,2F
R2019 T8144 T8141 prep 2F,2B
R2020 T8012 T8010 pobj mutants,of
R2021 T8145 T8141 punct ),2B
R2022 T8146 T8115 cc and,were
R2023 T8013 T8003 punct ", ",monitored
R2024 T8147 T8148 nsubj some,died
R2025 T8148 T8115 conj died,were
R2026 T8149 T8148 aux have,died
R2027 T8014 T8003 nsubj we,monitored
R2028 T8150 T8148 prep at,died
R2029 T8151 T8150 cc or,at
R2030 T8015 T8016 nummod three,litters
R2031 T8152 T8153 amod prior,to
R2032 T8153 T8150 conj to,at
R2033 T8154 T8155 det this,age
R2034 T8016 T8003 dobj litters,monitored
R2035 T8155 T8153 pobj age,to
R2036 T8156 T8115 punct .,were
R2037 T8017 T8003 prep from,monitored
R2038 T8158 T8159 nsubj None,survived
R2039 T8018 T8017 pobj birth,from
R2040 T8160 T8158 prep of,None
R2041 T8161 T8162 compound KA,mutants
R2042 T8162 T8160 pobj mutants,of
R2043 T8019 T8003 prep to,monitored
R2044 T8163 T8159 prep to,survived
R2045 T8164 T8165 amod weaning,age
R2046 T8165 T8163 pobj age,to
R2047 T8020 T8019 pobj weaning,to
R2048 T8166 T8159 punct .,survived
R2049 T8021 T8003 prep by,monitored
R2050 T8168 T8169 det "Table 1 Genotype Distribution of Progeny from the Matings Figure 2 Postnatal Mortality and Stunted Growth in K14-cre; ApcCKO/CKO Mutant Mice Animals whose genotype is either heterozygous or homozygous for the wild-type Apc allele are referred to as normal (N); those whose genotype are K14-cre; ApcCKO/CKO and show the presence of K14-cre–recombined mutant Apc allele are called mutant (M). (A) Two P3 mutant mice, M1 and M2, and their normal littermates, showing size variation among mutants. (B) P8 mutant mouse (right) and a normal littermate. Note sparseness of hair coat and abnormal ears. (C–D) Vibrissae of whisker pads are short and oddly angled in a P12 mutant mouse (C), relative to control (D). Note the lack of incisors in the mutant. (E) A P17 mutant mouse (right) with its littermate. Its bare forehead, dorsal median line, and abnormal ears are evident. (F) Growth curve of mutants and normal littermates. Mutants exhibit stunted growth, which became more prominent as they aged, and weigh significantly less than littermates from P8 (p < 0.05). (G) Comparison of mutant and normal thymus from P3 mice. The mutant thymus (left) is dramatically smaller for its age compared to the normal littermate (right). The scale bar equals 1 mm. (H) Skeletal preparations of normal (left) and mutant (right), showing differences in development of both incisor (I) and molar (M) teeth. The",ability
R2051 T8169 T8170 nsubjpass ability,used
R2052 T8022 T8021 pcomp measuring,by
R2053 T8171 T8169 prep of,ability
R2054 T8172 T8173 amod whole,embryos
R2055 T8173 T8171 pobj embryos,of
R2056 T8174 T8175 aux to,exclude
R2057 T8175 T8169 acl exclude,ability
R2058 T8176 T8177 amod blue,dye
R2059 T8023 T8024 det the,weight
R2060 T8177 T8175 dobj dye,exclude
R2061 T8178 T8170 auxpass was,used
R2062 T8179 T8180 aux to,examine
R2063 T8024 T8022 dobj weight,measuring
R2064 T8180 T8170 advcl examine,used
R2065 T8181 T8182 det the,barrier
R2066 T8182 T8180 dobj barrier,examine
R2067 T8183 T8182 amod epidermal,barrier
R2068 T8025 T8024 compound body,weight
R2069 T8184 T8182 punct ", ",barrier
R2070 T8185 T8186 advmod normally,acquired
R2071 T8186 T8182 acl acquired,barrier
R2072 T8187 T8186 advcl beginning,acquired
R2073 T8026 T8024 prep of,weight
R2074 T8188 T8187 prep at,beginning
R2075 T8189 T8188 pobj E16,at
R2076 T8190 T8187 cc and,beginning
R2077 T8027 T8028 det each,pup
R2078 T8191 T8187 conj complete,beginning
R2079 T8028 T8026 pobj pup,of
R2080 T8192 T8191 prep by,complete
R2081 T8029 T8030 det every,day
R2082 T8193 T8192 pobj E18.5,by
R2083 T8194 T8195 punct [,21
R2084 T8195 T8186 parataxis 21,acquired
R2085 T8030 T8022 npadvmod day,measuring
R2086 T8196 T8195 punct ],21
R2087 T8197 T8170 punct .,used
R2088 T8031 T8003 punct .,monitored
R2089 T8199 T8200 nsubj Analyses,showed
R2090 T8201 T8199 prep of,Analyses
R2091 T8033 T8034 quantmod A,25
R2092 T8202 T8203 nmod E17.5,mutants
R2093 T8203 T8201 pobj mutants,of
R2094 T8204 T8205 punct –,E18.5
R2095 T8246 T8230 punct ", ",were
R2096 T8205 T8202 prep E18.5,E17.5
R2097 T8206 T8203 compound KA,mutants
R2098 T8207 T8208 mark that,were
R2099 T8208 T8200 ccomp were,showed
R2100 T8209 T8208 nsubj they,were
R2101 T8247 T8230 cc but,were
R2102 T8210 T8208 acomp able,were
R2103 T8211 T8212 aux to,exclude
R2104 T8248 T8249 det the,mutants
R2105 T8212 T8210 xcomp exclude,able
R2106 T8213 T8214 amod blue,dye
R2107 T8214 T8212 dobj dye,exclude
R2108 T8215 T8200 punct ", ",showed
R2109 T8216 T8200 advcl indicating,showed
R2110 T8249 T8250 nsubj mutants,showed
R2111 T8217 T8218 mark that,was
R2112 T8218 T8216 ccomp was,indicating
R2113 T8219 T8220 det the,barrier
R2114 T8250 T8230 conj showed,were
R2115 T8220 T8218 nsubj barrier,was
R2116 T8221 T8220 amod epidermal,barrier
R2117 T8222 T8218 acomp intact,was
R2118 T8251 T8252 det a,patch
R2119 T8223 T8224 punct (,S2
R2120 T8224 T8218 parataxis S2,was
R2121 T8225 T8224 compound Figure,S2
R2122 T8252 T8250 dobj patch,showed
R2123 T8226 T8224 punct ),S2
R2124 T8227 T8200 punct .,showed
R2125 T8253 T8252 prep of,patch
R2126 T8229 T8230 prep At,were
R2127 T8254 T8255 punct “,birthmark
R2128 T8231 T8232 det these,ages
R2129 T8232 T8229 pobj ages,At
R2130 T8233 T8232 amod embryonic,ages
R2131 T8255 T8253 pobj birthmark,of
R2132 T8234 T8230 punct ", ",were
R2133 T8235 T8230 expl there,were
R2134 T8236 T8237 det no,differences
R2135 T8256 T8255 punct ”,birthmark
R2136 T8237 T8230 attr differences,were
R2137 T8238 T8237 prep in,differences
R2138 T8239 T8238 pobj size,in
R2139 T8257 T8255 cc or,birthmark
R2140 T8240 T8237 prep between,differences
R2141 T8241 T8242 det the,mutants
R2142 T8242 T8240 pobj mutants,between
R2143 T8258 T8259 amod dark,pigmentation
R2144 T8243 T8242 cc and,mutants
R2145 T8244 T8245 poss their,littermates
R2146 T8245 T8242 conj littermates,mutants
R2147 T8259 T8255 conj pigmentation,birthmark
R2148 T8260 T8252 prep on,patch
R2149 T8261 T8262 poss their,foreheads
R2150 T8262 T8260 pobj foreheads,on
R2151 T8352 T8353 advmod phenotypically,normal
R2152 T8263 T8252 cc and,patch
R2153 T8353 T8351 amod normal,littermates
R2154 T8354 T8355 det a,coat
R2155 T8355 T8349 dobj coat,had
R2156 T8264 T8265 det a,line
R2157 T8356 T8355 amod smooth,coat
R2158 T8357 T8355 amod thin,coat
R2159 T8358 T8355 prep of,coat
R2160 T8359 T8358 pobj hair,of
R2161 T8360 T8361 punct (,2B
R2162 T8265 T8252 conj line,patch
R2163 T8361 T8349 parataxis 2B,had
R2164 T8362 T8361 compound Figure,2B
R2165 T8363 T8361 punct ),2B
R2166 T8364 T8336 punct .,were
R2167 T8266 T8265 amod dark,line
R2168 T8267 T8265 amod median,line
R2169 T8366 T8367 prep At,start
R2170 T8268 T8269 dep that,ran
R2171 T8368 T8369 det this,age
R2172 T8369 T8366 pobj age,At
R2173 T8269 T8265 relcl ran,line
R2174 T8370 T8367 punct ", ",start
R2175 T8371 T8372 nummod two,incisors
R2176 T8372 T8367 nsubj incisors,start
R2177 T8270 T8269 advmod caudally,ran
R2178 T8373 T8372 amod lower,incisors
R2179 T8374 T8375 aux to,erupt
R2180 T8375 T8367 xcomp erupt,start
R2181 T8271 T8269 prep from,ran
R2182 T8376 T8375 prep in,erupt
R2183 T8377 T8378 amod normal,littermates
R2184 T8272 T8271 pobj head,from
R2185 T8378 T8376 pobj littermates,in
R2186 T8379 T8367 cc and,start
R2187 T8273 T8269 prep to,ran
R2188 T8380 T8381 nsubj these,were
R2189 T8381 T8367 conj were,start
R2190 T8382 T8381 acomp absent,were
R2191 T8274 T8273 pobj tail,to
R2192 T8383 T8381 prep in,were
R2193 T8384 T8385 det the,mutants
R2194 T8385 T8383 pobj mutants,in
R2195 T8275 T8250 punct .,showed
R2196 T8386 T8385 compound KA,mutants
R2197 T8387 T8388 punct (,2C
R2198 T8277 T8278 poss Their,ears
R2199 T8388 T8381 parataxis 2C,were
R2200 T8389 T8388 compound Figure,2C
R2201 T8390 T8388 cc and,2C
R2202 T8391 T8388 conj 2D,2C
R2203 T8392 T8388 punct ),2C
R2204 T8278 T8280 nsubj ears,were
R2205 T8393 T8381 punct .,were
R2206 T8395 T8396 nsubj Animals,tended
R2207 T8279 T8278 amod external,ears
R2208 T8397 T8396 advmod also,tended
R2209 T8281 T8278 cc or,ears
R2210 T8398 T8399 aux to,be
R2211 T8399 T8396 xcomp be,tended
R2212 T8400 T8399 acomp smaller,be
R2213 T8401 T8396 cc and,tended
R2214 T8402 T8403 prep around,displayed
R2215 T8403 T8396 conj displayed,tended
R2216 T8404 T8402 pobj P10,around
R2217 T8405 T8406 punct –,P12
R2218 T8282 T8278 conj pinnae,ears
R2219 T8406 T8404 prep P12,P10
R2220 T8407 T8408 advmod abnormally,short
R2221 T8408 T8409 amod short,vibrissae
R2222 T8283 T8280 acomp shriveled,were
R2223 T8409 T8403 dobj vibrissae,displayed
R2224 T8410 T8408 cc and,short
R2225 T8411 T8408 conj misshapen,short
R2226 T8284 T8283 prep in,shriveled
R2227 T8412 T8409 cc and,vibrissae
R2228 T8413 T8414 amod short,hairs
R2229 T8414 T8409 conj hairs,vibrissae
R2230 T8285 T8284 pobj appearance,in
R2231 T8415 T8414 punct ", ",hairs
R2232 T8286 T8283 cc and,shriveled
R2233 T8287 T8283 conj pigmented,shriveled
R2234 T8416 T8414 amod shaggy,hairs
R2235 T8288 T8280 prep compared,were
R2236 T8417 T8414 compound pelage,hairs
R2237 T8418 T8419 punct (,2C
R2238 T8289 T8288 prep to,compared
R2239 T8419 T8403 parataxis 2C,displayed
R2240 T8420 T8419 compound Figure,2C
R2241 T8421 T8419 cc and,2C
R2242 T8290 T8289 pobj those,to
R2243 T8422 T8419 conj 2D,2C
R2244 T8423 T8419 punct ),2C
R2245 T8424 T8396 punct .,tended
R2246 T8291 T8290 prep of,those
R2247 T8426 T8427 nsubj Development,became
R2248 T8292 T8291 pobj littermates,of
R2249 T8428 T8426 prep of,Development
R2250 T8429 T8430 amod thick,ridges
R2251 T8293 T8280 punct .,were
R2252 T8430 T8428 pobj ridges,of
R2253 T8431 T8430 prep in,ridges
R2254 T8432 T8433 poss their,skin
R2255 T8295 T8296 amod External,characteristics
R2256 T8433 T8431 pobj skin,in
R2257 T8434 T8430 punct ", ",ridges
R2258 T8435 T8436 advmod particularly,around
R2259 T8436 T8430 prep around,ridges
R2260 T8296 T8297 nsubj characteristics,persisted
R2261 T8437 T8438 det the,ears
R2262 T8438 T8436 pobj ears,around
R2263 T8439 T8438 punct ", ",ears
R2264 T8440 T8438 conj eyelids,ears
R2265 T8441 T8440 punct ", ",eyelids
R2266 T8298 T8296 prep of,characteristics
R2267 T8442 T8440 conj forehead,eyelids
R2268 T8443 T8442 punct ", ",forehead
R2269 T8444 T8442 conj nose,forehead
R2270 T8445 T8444 punct ", ",nose
R2271 T8446 T8444 cc and,nose
R2272 T8447 T8444 conj paws,nose
R2273 T8299 T8300 compound KA,mutants
R2274 T8448 T8427 punct ", ",became
R2275 T8449 T8427 acomp noticeable,became
R2276 T8450 T8451 punct (,2E
R2277 T8300 T8298 pobj mutants,of
R2278 T8301 T8302 dep that,were
R2279 T8451 T8427 parataxis 2E,became
R2280 T8302 T8300 relcl were,mutants
R2281 T8452 T8451 compound Figure,2E
R2282 T8453 T8451 punct ),2E
R2283 T8303 T8302 acomp evident,were
R2284 T8454 T8427 punct .,became
R2285 T8304 T8302 prep at,were
R2286 T8456 T8457 det These,regions
R2287 T8457 T8458 nsubj regions,looked
R2288 T8305 T8304 pobj E18.5,at
R2289 T8306 T8297 prep after,persisted
R2290 T8307 T8306 pobj birth,after
R2291 T8459 T8458 acomp scaly,looked
R2292 T8460 T8458 punct ", ",looked
R2293 T8308 T8297 cc and,persisted
R2294 T8461 T8458 cc and,looked
R2295 T8309 T8297 conj became,persisted
R2296 T8462 T8463 det these,animals
R2297 T8463 T8464 nsubj animals,kept
R2298 T8464 T8458 conj kept,looked
R2299 T8310 T8311 advmod more,prominent
R2300 T8465 T8464 advmod hardly,kept
R2301 T8466 T8467 poss their,eyes
R2302 T8311 T8309 acomp prominent,became
R2303 T8467 T8464 dobj eyes,kept
R2304 T8468 T8464 oprd open,kept
R2305 T8469 T8464 punct .,kept
R2306 T8312 T8313 mark as,grew
R2307 T8471 T8472 prep In,started
R2308 T8313 T8309 advcl grew,became
R2309 T8472 T8490 ccomp started,were
R2310 T8473 T8471 pobj contrast,In
R2311 T8474 T8473 prep to,contrast
R2312 T8314 T8313 nsubj they,grew
R2313 T8475 T8476 det the,littermates
R2314 T8476 T8474 pobj littermates,to
R2315 T8477 T8476 amod normal,littermates
R2316 T8478 T8479 dep that,increased
R2317 T8479 T8476 relcl increased,littermates
R2318 T8480 T8479 advmod consistently,increased
R2319 T8315 T8316 punct (,2A
R2320 T8481 T8482 poss their,weight
R2321 T8482 T8479 dobj weight,increased
R2322 T8483 T8482 compound body,weight
R2323 T8316 T8309 parataxis 2A,became
R2324 T8484 T8479 prep with,increased
R2325 T8485 T8484 pobj age,with
R2326 T8317 T8316 compound Figure,2A
R2327 T8486 T8472 punct ", ",started
R2328 T8487 T8488 amod surviving,mutants
R2329 T8488 T8472 nsubj mutants,started
R2330 T8318 T8319 punct –,2F
R2331 T8489 T8488 compound KA,mutants
R2332 T8491 T8492 aux to,lose
R2333 T8319 T8316 prep 2F,2A
R2334 T8492 T8472 xcomp lose,started
R2335 T8493 T8492 dobj weight,lose
R2336 T8494 T8492 prep from,lose
R2337 T8320 T8316 punct ),2A
R2338 T8495 T8494 pobj P10,from
R2339 T8496 T8495 advmod onwards,P10
R2340 T8497 T8490 punct ;,were
R2341 T8321 T8297 punct .,persisted
R2342 T8498 T8490 prep by,were
R2343 T8499 T8498 pobj P16,by
R2344 T8500 T8501 punct –,P17
R2345 T8323 T8324 nsubjpass Growth,delayed
R2346 T8501 T8499 prep P17,P16
R2347 T8502 T8490 nsubj they,were
R2348 T8503 T8490 advmod all,were
R2349 T8504 T8490 acomp lethargic,were
R2350 T8325 T8323 prep of,Growth
R2351 T8505 T8490 punct ", ",were
R2352 T8506 T8490 cc and,were
R2353 T8507 T8508 nsubj none,survived
R2354 T8508 T8490 conj survived,were
R2355 T8326 T8327 compound pelage,hair
R2356 T8509 T8507 prep of,none
R2357 T8510 T8509 pobj them,of
R2358 T8511 T8508 prep to,survived
R2359 T8327 T8325 pobj hair,of
R2360 T8512 T8511 pobj weaning,to
R2361 T8513 T8514 punct (,2E
R2362 T8514 T8508 parataxis 2E,survived
R2363 T8328 T8324 auxpass was,delayed
R2364 T8515 T8514 compound Figure,2E
R2365 T8516 T8514 cc and,2E
R2366 T8517 T8514 conj 2F,2E
R2367 T8518 T8514 punct ),2E
R2368 T8519 T8490 punct .,were
R2369 T8329 T8324 advmod generally,delayed
R2370 T8521 T8522 prep At,were
R2371 T8330 T8324 prep in,delayed
R2372 T8523 T8524 det the,time
R2373 T8524 T8521 pobj time,At
R2374 T8525 T8524 prep of,time
R2375 T8331 T8332 det the,mutants
R2376 T8526 T8525 pobj autopsy,of
R2377 T8527 T8528 predet all,mutants
R2378 T8528 T8522 nsubj mutants,were
R2379 T8332 T8330 pobj mutants,in
R2380 T8529 T8528 det the,mutants
R2381 T8530 T8522 acomp toothless,were
R2382 T8531 T8522 punct ", ",were
R2383 T8532 T8522 prep without,were
R2384 T8333 T8324 punct .,delayed
R2385 T8533 T8532 pobj incisors,without
R2386 T8534 T8533 cc or,incisors
R2387 T8535 T8533 conj molars,incisors
R2388 T8335 T8336 prep At,were
R2389 T8536 T8522 punct ", ",were
R2390 T8537 T8522 cc and,were
R2391 T8337 T8338 advmod around,P8
R2392 T8538 T8539 poss their,stomachs
R2393 T8539 T8540 nsubj stomachs,were
R2394 T8540 T8522 conj were,were
R2395 T8338 T8335 pobj P8,At
R2396 T8541 T8540 advmod consistently,were
R2397 T8542 T8540 acomp small,were
R2398 T8543 T8540 cc and,were
R2399 T8339 T8336 punct ", ",were
R2400 T8544 T8540 conj had,were
R2401 T8545 T8546 det no,food
R2402 T8340 T8341 det the,mutants
R2403 T8546 T8544 dobj food,had
R2404 T8547 T8546 amod solid,food
R2405 T8341 T8336 nsubj mutants,were
R2406 T8548 T8544 punct ", ",had
R2407 T8549 T8544 prep unlike,had
R2408 T8550 T8551 poss their,littermates
R2409 T8342 T8341 compound KA,mutants
R2410 T8551 T8549 pobj littermates,unlike
R2411 T8552 T8553 npadvmod age,matched
R2412 T8553 T8551 amod matched,littermates
R2413 T8343 T8336 acomp hairless,were
R2414 T8554 T8553 punct -,matched
R2415 T8555 T8522 punct ", ",were
R2416 T8556 T8522 advcl suggesting,were
R2417 T8344 T8336 cc and,were
R2418 T8557 T8558 mark that,be
R2419 T8558 T8556 ccomp be,suggesting
R2420 T8559 T8560 det the,loss
R2421 T8560 T8558 nsubj loss,be
R2422 T8561 T8560 amod observed,loss
R2423 T8345 T8336 conj had,were
R2424 T8562 T8560 compound weight,loss
R2425 T8563 T8558 aux could,be
R2426 T8346 T8347 amod wrinkled,skin
R2427 T8347 T8345 dobj skin,had
R2428 T8564 T8565 det the,result
R2429 T8348 T8349 mark while,had
R2430 T8565 T8558 attr result,be
R2431 T8349 T8336 advcl had,were
R2432 T8566 T8565 prep of,result
R2433 T8567 T8566 pobj failure,of
R2434 T8568 T8569 aux to,ingest
R2435 T8569 T8567 acl ingest,failure
R2436 T8350 T8351 poss their,littermates
R2437 T8570 T8571 amod solid,food
R2438 T8571 T8569 dobj food,ingest
R2439 T8572 T8573 punct (,2F
R2440 T8351 T8349 nsubj littermates,had
R2441 T8573 T8558 parataxis 2F,be
R2442 T8574 T8573 compound Figure,2F
R2443 T8575 T8573 punct ),2F
R2444 T8670 T8669 punct -,mediated
R2445 T8576 T8522 punct .,were
R2446 T8578 T8579 advmod Interestingly,varied
R2447 T8671 T8667 pobj deletion,of
R2448 T8580 T8579 punct ", ",varied
R2449 T8581 T8579 nsubj changes,varied
R2450 T8582 T8581 prep in,changes
R2451 T8672 T8671 compound Apc,deletion
R2452 T8583 T8584 compound body,weights
R2453 T8584 T8582 pobj weights,in
R2454 T8585 T8584 cc and,weights
R2455 T8673 T8655 punct .,suggests
R2456 T8586 T8584 conj timing,weights
R2457 T8587 T8586 prep of,timing
R2458 T8588 T8589 compound hair,growth
R2459 T8675 T8676 nsubj It,is
R2460 T8589 T8587 pobj growth,of
R2461 T8590 T8579 advmod considerably,varied
R2462 T8591 T8579 prep among,varied
R2463 T8592 T8593 amod mutant,pups
R2464 T8677 T8676 acomp possible,is
R2465 T8593 T8591 pobj pups,among
R2466 T8594 T8595 advmod even,were
R2467 T8595 T8579 advcl were,varied
R2468 T8596 T8595 mark if,were
R2469 T8678 T8679 mark that,has
R2470 T8597 T8595 nsubj they,were
R2471 T8598 T8595 prep from,were
R2472 T8599 T8600 det the,litter
R2473 T8600 T8598 pobj litter,from
R2474 T8601 T8600 amod same,litter
R2475 T8602 T8595 punct ", ",were
R2476 T8679 T8676 ccomp has,is
R2477 T8603 T8604 mark whereas,tended
R2478 T8604 T8595 advcl tended,were
R2479 T8605 T8604 nsubj those,tended
R2480 T8680 T8681 det the,background
R2481 T8606 T8605 prep of,those
R2482 T8607 T8608 advmod phenotypically,normal
R2483 T8681 T8679 nsubj background,has
R2484 T8608 T8609 amod normal,littermates
R2485 T8609 T8606 pobj littermates,of
R2486 T8610 T8611 aux to,be
R2487 T8682 T8681 amod genetic,background
R2488 T8611 T8604 xcomp be,tended
R2489 T8612 T8611 acomp similar,be
R2490 T8613 T8579 punct .,varied
R2491 T8683 T8684 det a,role
R2492 T8615 T8616 det This,difference
R2493 T8616 T8617 nsubjpass difference,reflected
R2494 T8684 T8679 dobj role,has
R2495 T8617 T8620 ccomp reflected,survived
R2496 T8618 T8617 auxpass was,reflected
R2497 T8685 T8686 aux to,play
R2498 T8619 T8617 advmod also,reflected
R2499 T8621 T8617 prep in,reflected
R2500 T8686 T8684 advcl play,role
R2501 T8687 T8686 prep in,play
R2502 T8622 T8623 det the,variation
R2503 T8623 T8621 pobj variation,in
R2504 T8688 T8689 det this,variability
R2505 T8624 T8623 prep in,variation
R2506 T8625 T8624 pobj timing,in
R2507 T8626 T8625 prep of,timing
R2508 T8689 T8687 pobj variability,in
R2509 T8627 T8626 pobj death,of
R2510 T8628 T8623 prep in,variation
R2511 T8629 T8628 pobj mutants,in
R2512 T8630 T8620 punct : ,survived
R2513 T8690 T8676 punct .,is
R2514 T8631 T8632 det some,pups
R2515 T8632 T8634 nsubjpass pups,born
R2516 T8692 T8693 amod Gross,examination
R2517 T8633 T8632 amod mutant,pups
R2518 T8634 T8620 ccomp born,survived
R2519 T8635 T8634 auxpass were,born
R2520 T8636 T8634 advcl alive,born
R2521 T8693 T8694 nsubj examination,showed
R2522 T8637 T8634 cc but,born
R2523 T8638 T8634 conj died,born
R2524 T8639 T8638 prep within,died
R2525 T8640 T8641 nummod a,day
R2526 T8641 T8639 pobj day,within
R2527 T8642 T8643 cc or,two
R2528 T8643 T8641 nummod two,day
R2529 T8695 T8693 prep of,examination
R2530 T8644 T8620 punct ", ",survived
R2531 T8645 T8620 nsubj some,survived
R2532 T8646 T8620 advmod close,survived
R2533 T8647 T8646 prep to,close
R2534 T8696 T8697 amod internal,organs
R2535 T8648 T8649 det the,age
R2536 T8649 T8647 pobj age,to
R2537 T8650 T8649 amod weaning,age
R2538 T8697 T8695 pobj organs,of
R2539 T8651 T8620 punct .,survived
R2540 T8698 T8694 advmod also,showed
R2541 T8653 T8654 det This,variability
R2542 T8654 T8655 nsubj variability,suggests
R2543 T8699 T8700 mark that,were
R2544 T8656 T8654 prep of,variability
R2545 T8657 T8658 det the,phenotypes
R2546 T8658 T8656 pobj phenotypes,of
R2547 T8659 T8658 amod mutant,phenotypes
R2548 T8700 T8694 ccomp were,showed
R2549 T8660 T8661 amod possible,variation
R2550 T8661 T8655 dobj variation,suggests
R2551 T8701 T8702 det the,mutants
R2552 T8662 T8661 prep in,variation
R2553 T8663 T8664 det the,timing
R2554 T8664 T8662 pobj timing,in
R2555 T8665 T8664 cc and,timing
R2556 T8702 T8703 poss mutants,thymi
R2557 T8666 T8664 conj efficiency,timing
R2558 T8667 T8664 prep of,timing
R2559 T8668 T8669 npadvmod cre,mediated
R2560 T8703 T8700 nsubj thymi,were
R2561 T8669 T8671 amod mediated,deletion
R2562 T8704 T8702 case ',mutants
R2563 T8705 T8706 advmod consistently,inconspicuous
R2564 T8776 T8774 dobj specimens,preparing
R2565 T8706 T8700 acomp inconspicuous,were
R2566 T8777 T8776 prep of,specimens
R2567 T8778 T8779 nmod P16,mice
R2568 T8779 T8777 pobj mice,of
R2569 T8707 T8700 cc and,were
R2570 T8780 T8781 punct –,P17
R2571 T8781 T8778 prep P17,P16
R2572 T8782 T8779 acl stained,mice
R2573 T8783 T8782 prep with,stained
R2574 T8784 T8785 compound Alizarin,red
R2575 T8785 T8783 pobj red,with
R2576 T8786 T8766 punct .,examined
R2577 T8708 T8700 conj were,were
R2578 T8788 T8789 det No,differences
R2579 T8789 T8790 nsubjpass differences,detected
R2580 T8709 T8710 advmod very,small
R2581 T8791 T8789 prep between,differences
R2582 T8792 T8793 det the,mice
R2583 T8710 T8708 acomp small,were
R2584 T8711 T8710 prep for,small
R2585 T8793 T8791 pobj mice,between
R2586 T8712 T8713 poss their,age
R2587 T8794 T8793 amod normal,mice
R2588 T8795 T8794 cc and,normal
R2589 T8796 T8797 npadvmod KA,mutant
R2590 T8713 T8711 pobj age,for
R2591 T8797 T8794 conj mutant,normal
R2592 T8798 T8789 prep in,differences
R2593 T8799 T8800 det the,bone
R2594 T8714 T8700 punct ", ",were
R2595 T8800 T8798 pobj bone,in
R2596 T8801 T8800 amod mandibular,bone
R2597 T8802 T8790 aux can,detected
R2598 T8715 T8716 mark whereas,were
R2599 T8803 T8790 auxpass be,detected
R2600 T8804 T8790 punct ", ",detected
R2601 T8716 T8700 advcl were,were
R2602 T8805 T8790 cc but,detected
R2603 T8717 T8716 nsubj those,were
R2604 T8806 T8807 det the,mice
R2605 T8807 T8809 nsubj mice,lacked
R2606 T8718 T8717 prep of,those
R2607 T8719 T8720 poss their,littermates
R2608 T8808 T8807 amod mutant,mice
R2609 T8720 T8718 pobj littermates,of
R2610 T8721 T8722 advmod very,prominent
R2611 T8722 T8716 acomp prominent,were
R2612 T8809 T8790 conj lacked,detected
R2613 T8810 T8809 cc or,lacked
R2614 T8723 T8722 prep in,prominent
R2615 T8811 T8809 conj had,lacked
R2616 T8812 T8813 amod underdeveloped,set
R2617 T8813 T8811 dative set,had
R2618 T8724 T8723 pobj size,in
R2619 T8814 T8813 prep of,set
R2620 T8815 T8816 amod maxillary,incisors
R2621 T8816 T8811 dobj incisors,had
R2622 T8725 T8726 punct (,2G
R2623 T8817 T8816 cc and,incisors
R2624 T8818 T8816 conj molars,incisors
R2625 T8819 T8820 punct (,2H
R2626 T8820 T8811 parataxis 2H,had
R2627 T8821 T8820 compound Figure,2H
R2628 T8822 T8820 punct ),2H
R2629 T8726 T8716 parataxis 2G,were
R2630 T8823 T8809 punct .,lacked
R2631 T8825 T8826 nsubj We,detected
R2632 T8727 T8726 compound Figure,2G
R2633 T8827 T8828 det no,abnormalities
R2634 T8828 T8826 dobj abnormalities,detected
R2635 T8728 T8726 punct ),2G
R2636 T8829 T8828 amod other,abnormalities
R2637 T8830 T8828 amod major,abnormalities
R2638 T8729 T8694 punct .,showed
R2639 T8831 T8828 amod skeletal,abnormalities
R2640 T8832 T8826 punct .,detected
R2641 T8731 T8732 det This,difference
R2642 T8732 T8733 nsubj difference,was
R2643 T8734 T8733 acomp evident,was
R2644 T8735 T8736 advmod as,early
R2645 T8736 T8733 advmod early,was
R2646 T8737 T8736 prep as,early
R2647 T8738 T8737 pobj P3,as
R2648 T8739 T8733 punct .,was
R2649 T8741 T8742 advmod Quite,frequently
R2650 T8742 T8743 advmod frequently,contained
R2651 T8744 T8745 amod mutant,thymi
R2652 T8745 T8743 nsubj thymi,contained
R2653 T8746 T8745 prep in,thymi
R2654 T8747 T8748 nmod P12,mice
R2655 T8748 T8746 pobj mice,in
R2656 T8749 T8750 punct –,P17
R2657 T8750 T8747 prep P17,P12
R2658 T8751 T8748 amod mutant,mice
R2659 T8752 T8743 advmod also,contained
R2660 T8753 T8754 amod black,deposits
R2661 T8754 T8743 dobj deposits,contained
R2662 T8755 T8743 prep within,contained
R2663 T8756 T8757 det the,tissue
R2664 T8757 T8755 pobj tissue,within
R2665 T8758 T8759 punct (,data
R2666 T8759 T8743 meta data,contained
R2667 T8760 T8759 amod unpublished,data
R2668 T8761 T8759 punct ),data
R2669 T8762 T8743 punct .,contained
R2670 T8764 T8765 amod Mutant,mice
R2671 T8765 T8766 nsubjpass mice,examined
R2672 T8767 T8766 auxpass were,examined
R2673 T8768 T8766 advmod also,examined
R2674 T8769 T8766 prep for,examined
R2675 T8770 T8771 det any,abnormalities
R2676 T8771 T8769 pobj abnormalities,for
R2677 T8772 T8771 amod skeletal,abnormalities
R2678 T8773 T8766 prep by,examined
R2679 T8774 T8773 pcomp preparing,by
R2680 T8775 T8776 amod skeletal,specimens