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PMC:1540739 / 5543-6126 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T3364 0-3 DT denotes The
T3366 4-8 NN denotes RMCE
T3365 9-17 NN denotes strategy
T3368 18-27 VBN denotes presented
T3369 28-32 RB denotes here
T3367 33-39 VBZ denotes relies
T3370 40-42 IN denotes on
T3371 43-46 DT denotes the
T3373 47-57 VBN denotes integrated
T3372 58-61 NN denotes use
T3374 62-64 IN denotes of
T3375 65-73 VBN denotes inverted
T3377 74-86 JJ denotes heterologous
T3378 87-91 NN denotes loxP
T3376 92-97 NNS denotes sites
T3379 97-99 , denotes ,
T3380 99-100 DT denotes a
T3382 101-109 JJ denotes positive
T3384 109-110 HYPH denotes /
T3383 110-118 JJ denotes negative
T3385 119-128 NN denotes selection
T3381 129-135 NN denotes marker
T3386 136-140 WDT denotes that
T3387 141-150 VBZ denotes preserves
T3388 151-154 DT denotes the
T3390 155-163 NN denotes germline
T3389 164-172 NN denotes capacity
T3391 173-175 IN denotes of
T3392 176-178 NN denotes ES
T3393 179-184 NNS denotes cells
T3394 184-186 , denotes ,
T3395 186-189 CC denotes and
T3396 190-193 DT denotes the
T3397 194-199 NN denotes power
T3398 200-202 IN denotes of
T3399 203-208 NN denotes mouse
T3400 209-217 NN denotes genetics
T3401 218-220 TO denotes to
T3402 221-229 VB denotes expedite
T3403 230-240 JJ denotes phenotypic
T3404 241-249 NNS denotes analyses
T3405 249-250 . denotes .
T3406 250-484 sentence denotes We show that our approach enables efficient targeting of marker-free mutations at the p53 locus in ES cells to generate mutant mice, but more importantly, it is Adapted for targeting in Somatic cells to Accelerate Phenotyping (ASAP).
T3407 251-253 PRP denotes We
T3408 254-258 VBP denotes show
T3409 259-263 IN denotes that
T3411 264-267 PRP$ denotes our
T3412 268-276 NN denotes approach
T3410 277-284 VBZ denotes enables
T3413 285-294 JJ denotes efficient
T3414 295-304 NN denotes targeting
T3415 305-307 IN denotes of
T3416 308-314 JJ denotes marker
T3418 314-315 HYPH denotes -
T3417 315-319 JJ denotes free
T3419 320-329 NNS denotes mutations
T3420 330-332 IN denotes at
T3421 333-336 DT denotes the
T3423 337-340 NN denotes p53
T3422 341-346 NN denotes locus
T3424 347-349 IN denotes in
T3425 350-352 NN denotes ES
T3426 353-358 NNS denotes cells
T3427 359-361 TO denotes to
T3428 362-370 VB denotes generate
T3429 371-377 JJ denotes mutant
T3430 378-382 NNS denotes mice
T3431 382-384 , denotes ,
T3432 384-387 CC denotes but
T3433 388-392 RBR denotes more
T3434 393-404 RB denotes importantly
T3436 404-406 , denotes ,
T3437 406-408 PRP denotes it
T3438 409-411 VBZ denotes is
T3435 412-419 VBN denotes Adapted
T3439 420-423 IN denotes for
T3440 424-433 VBG denotes targeting
T3441 434-436 IN denotes in
T3442 437-444 JJ denotes Somatic
T3443 445-450 NNS denotes cells
T3444 451-453 TO denotes to
T3445 454-464 VB denotes Accelerate
T3446 465-476 NN denotes Phenotyping
T3447 477-478 -LRB- denotes (
T3448 478-482 NN denotes ASAP
T3449 482-483 -RRB- denotes )
T3450 483-484 . denotes .
T3451 484-583 sentence denotes Because it relies on very general principles, RMCE-ASAP could be applied to any locus of interest.
T3452 485-492 IN denotes Because
T3454 493-495 PRP denotes it
T3453 496-502 VBZ denotes relies
T3456 503-505 IN denotes on
T3457 506-510 RB denotes very
T3459 511-518 JJ denotes general
T3458 519-529 NNS denotes principles
T3460 529-531 , denotes ,
T3461 531-535 NN denotes RMCE
T3463 535-536 HYPH denotes -
T3462 536-540 NN denotes ASAP
T3464 541-546 MD denotes could
T3465 547-549 VB denotes be
T3455 550-557 VBN denotes applied
T3466 558-560 IN denotes to
T3467 561-564 DT denotes any
T3468 565-570 NN denotes locus
T3469 571-573 IN denotes of
T3470 574-582 NN denotes interest
T3471 582-583 . denotes .
R1000 T3385 T3381 compound selection,marker
R1001 T3386 T3387 dep that,preserves
R1002 T3387 T3381 relcl preserves,marker
R1003 T3388 T3389 det the,capacity
R1004 T3389 T3387 dobj capacity,preserves
R1005 T3390 T3389 compound germline,capacity
R1006 T3391 T3389 prep of,capacity
R1007 T3392 T3393 compound ES,cells
R1008 T3393 T3391 pobj cells,of
R1009 T3394 T3381 punct ", ",marker
R1010 T3395 T3381 cc and,marker
R1011 T3396 T3397 det the,power
R1012 T3397 T3381 conj power,marker
R1013 T3398 T3397 prep of,power
R1014 T3399 T3400 compound mouse,genetics
R1015 T3400 T3398 pobj genetics,of
R1016 T3401 T3402 aux to,expedite
R1017 T3402 T3367 advcl expedite,relies
R1018 T3403 T3404 amod phenotypic,analyses
R1019 T3404 T3402 dobj analyses,expedite
R1020 T3405 T3367 punct .,relies
R1021 T3407 T3408 nsubj We,show
R1022 T3409 T3410 mark that,enables
R1023 T3410 T3408 ccomp enables,show
R1024 T3411 T3412 poss our,approach
R1025 T3412 T3410 nsubj approach,enables
R1026 T3413 T3414 amod efficient,targeting
R1027 T3414 T3410 dobj targeting,enables
R1028 T3415 T3414 prep of,targeting
R1029 T3416 T3417 amod marker,free
R1030 T3417 T3419 amod free,mutations
R1031 T3418 T3417 punct -,free
R1032 T3419 T3415 pobj mutations,of
R1033 T3420 T3419 prep at,mutations
R1034 T3421 T3422 det the,locus
R1035 T3422 T3420 pobj locus,at
R1036 T3423 T3422 compound p53,locus
R1037 T3424 T3414 prep in,targeting
R1038 T3425 T3426 compound ES,cells
R1039 T3426 T3424 pobj cells,in
R1040 T3427 T3428 aux to,generate
R1041 T3428 T3410 xcomp generate,enables
R1042 T3429 T3430 amod mutant,mice
R1043 T3430 T3428 dobj mice,generate
R1044 T3431 T3408 punct ", ",show
R1045 T3432 T3408 cc but,show
R1046 T3433 T3434 advmod more,importantly
R1047 T3434 T3435 advmod importantly,Adapted
R1048 T3435 T3408 conj Adapted,show
R1049 T3436 T3435 punct ", ",Adapted
R937 T3364 T3365 det The,strategy
R941 T3365 T3367 nsubj strategy,relies
R945 T3366 T3365 compound RMCE,strategy
R947 T3368 T3365 acl presented,strategy
R951 T3369 T3368 advmod here,presented
R952 T3370 T3367 prep on,relies
R953 T3371 T3372 det the,use
R954 T3372 T3370 pobj use,on
R955 T3437 T3435 nsubjpass it,Adapted
R956 T3373 T3372 amod integrated,use
R957 T3438 T3435 auxpass is,Adapted
R958 T3439 T3435 prep for,Adapted
R959 T3374 T3372 prep of,use
R960 T3440 T3439 pobj targeting,for
R961 T3375 T3376 amod inverted,sites
R962 T3441 T3440 prep in,targeting
R963 T3442 T3443 amod Somatic,cells
R964 T3443 T3441 pobj cells,in
R965 T3376 T3374 pobj sites,of
R966 T3444 T3445 aux to,Accelerate
R967 T3445 T3435 advcl Accelerate,Adapted
R968 T3377 T3376 amod heterologous,sites
R969 T3446 T3445 dobj Phenotyping,Accelerate
R970 T3447 T3446 punct (,Phenotyping
R971 T3448 T3446 appos ASAP,Phenotyping
R972 T3449 T3435 punct ),Adapted
R973 T3378 T3376 compound loxP,sites
R974 T3450 T3435 punct .,Adapted
R975 T3379 T3372 punct ", ",use
R976 T3452 T3453 mark Because,relies
R977 T3453 T3455 advcl relies,applied
R978 T3454 T3453 nsubj it,relies
R979 T3456 T3453 prep on,relies
R980 T3457 T3458 advmod very,principles
R981 T3380 T3381 det a,marker
R982 T3458 T3456 pobj principles,on
R983 T3459 T3458 amod general,principles
R984 T3460 T3455 punct ", ",applied
R985 T3381 T3372 conj marker,use
R986 T3461 T3462 compound RMCE,ASAP
R987 T3462 T3455 nsubjpass ASAP,applied
R988 T3463 T3462 punct -,ASAP
R989 T3382 T3383 amod positive,negative
R990 T3464 T3455 aux could,applied
R991 T3465 T3455 auxpass be,applied
R992 T3466 T3455 prep to,applied
R993 T3383 T3385 nmod negative,selection
R994 T3467 T3468 det any,locus
R995 T3468 T3466 pobj locus,to
R996 T3469 T3468 prep of,locus
R997 T3384 T3383 punct /,negative
R998 T3470 T3469 pobj interest,of
R999 T3471 T3455 punct .,applied