PMC:1540739 / 1652-2242 5 Projects
Annnotations
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T2667 | 8-12 | IN | denotes | from |
| T2668 | 13-16 | DT | denotes | the |
| T2670 | 17-27 | JJ | denotes | endogenous |
| T2669 | 28-36 | NN | denotes | promoter |
| T2671 | 36-38 | , | denotes | , |
| T2672 | 38-46 | VBG | denotes | ensuring |
| T2673 | 47-60 | JJ | denotes | physiological |
| T2675 | 61-71 | NN | denotes | expression |
| T2674 | 72-78 | NNS | denotes | levels |
| T2676 | 79-82 | CC | denotes | and |
| T2677 | 83-90 | JJ | denotes | correct |
| T2679 | 91-97 | JJ | denotes | spatio |
| T2681 | 97-98 | HYPH | denotes | - |
| T2680 | 98-106 | JJ | denotes | temporal |
| T2678 | 107-115 | NNS | denotes | profiles |
| T2682 | 115-116 | . | denotes | . |
| T2683 | 116-382 | sentence | denotes | As significant differences between phenotypes from targeted p53 mutants in vivo and transfection data were observed [e.g. Refs (1–5)], more targeted mutations need to be generated and analyzed in multiple tissues to formulate more accurate models of p53 regulation. |
| T2684 | 117-119 | IN | denotes | As |
| T2686 | 120-131 | JJ | denotes | significant |
| T2687 | 132-143 | NNS | denotes | differences |
| T2688 | 144-151 | IN | denotes | between |
| T2689 | 152-162 | NNS | denotes | phenotypes |
| T2690 | 163-167 | IN | denotes | from |
| T2691 | 168-176 | VBN | denotes | targeted |
| T2693 | 177-180 | NN | denotes | p53 |
| T2692 | 181-188 | NNS | denotes | mutants |
| T2694 | 189-191 | FW | denotes | in |
| T2695 | 192-196 | FW | denotes | vivo |
| T2696 | 197-200 | CC | denotes | and |
| T2697 | 201-213 | NN | denotes | transfection |
| T2698 | 214-218 | NNS | denotes | data |
| T2699 | 219-223 | VBD | denotes | were |
| T2685 | 224-232 | VBN | denotes | observed |
| T2701 | 233-234 | -LRB- | denotes | [ |
| T2703 | 234-238 | FW | denotes | e.g. |
| T2704 | 239-243 | NNS | denotes | Refs |
| T2705 | 244-245 | -LRB- | denotes | ( |
| T2702 | 245-246 | CD | denotes | 1 |
| T2706 | 246-247 | SYM | denotes | – |
| T2707 | 247-248 | CD | denotes | 5 |
| T2708 | 248-249 | -RRB- | denotes | ) |
| T2709 | 249-250 | -RRB- | denotes | ] |
| T2710 | 250-252 | , | denotes | , |
| T2711 | 252-256 | RBR | denotes | more |
| T2712 | 257-265 | VBN | denotes | targeted |
| T2713 | 266-275 | NNS | denotes | mutations |
| T2700 | 276-280 | VBP | denotes | need |
| T2714 | 281-283 | TO | denotes | to |
| T2716 | 284-286 | VB | denotes | be |
| T2715 | 287-296 | VBN | denotes | generated |
| T2717 | 297-300 | CC | denotes | and |
| T2718 | 301-309 | VBN | denotes | analyzed |
| T2719 | 310-312 | IN | denotes | in |
| T2720 | 313-321 | JJ | denotes | multiple |
| T2721 | 322-329 | NNS | denotes | tissues |
| T2722 | 330-332 | TO | denotes | to |
| T2723 | 333-342 | VB | denotes | formulate |
| T2724 | 343-347 | RBR | denotes | more |
| T2725 | 348-356 | JJ | denotes | accurate |
| T2726 | 357-363 | NNS | denotes | models |
| T2727 | 364-366 | IN | denotes | of |
| T2728 | 367-370 | NN | denotes | p53 |
| T2729 | 371-381 | NN | denotes | regulation |
| T2730 | 381-382 | . | denotes | . |
| T2732 | 383-390 | RB | denotes | However |
| T2734 | 390-392 | , | denotes | , |
| T2735 | 392-397 | VBG | denotes | using |
| T2736 | 398-408 | JJ | denotes | homologous |
| T2737 | 409-422 | NN | denotes | recombination |
| T2738 | 423-425 | IN | denotes | in |
| T2739 | 426-428 | NN | denotes | ES |
| T2740 | 429-434 | NNS | denotes | cells |
| T2741 | 435-437 | TO | denotes | to |
| T2742 | 438-446 | VB | denotes | generate |
| T2743 | 447-453 | JJ | denotes | mutant |
| T2744 | 454-458 | NNS | denotes | mice |
| T2733 | 459-461 | VBZ | denotes | is |
| T2745 | 462-464 | DT | denotes | an |
| T2747 | 465-476 | JJ | denotes | inefficient |
| T2748 | 476-478 | , | denotes | , |
| T2749 | 478-482 | JJ | denotes | slow |
| T2750 | 483-486 | CC | denotes | and |
| T2751 | 487-496 | JJ | denotes | expensive |
| T2746 | 497-503 | NN | denotes | method |
| T2752 | 504-511 | IN | denotes | because |
| T2754 | 512-513 | -LRB- | denotes | ( |
| T2755 | 513-514 | LS | denotes | i |
| T2756 | 514-515 | -RRB- | denotes | ) |
| T2757 | 516-526 | JJ | denotes | homologous |
| T2758 | 527-540 | NN | denotes | recombination |
| T2759 | 541-550 | RB | denotes | typically |
| T2753 | 551-557 | VBZ | denotes | occurs |
| T2760 | 558-560 | IN | denotes | at |
| T2761 | 561-564 | JJ | denotes | low |
| T2762 | 565-574 | NN | denotes | frequency |
| T2763 | 575-577 | IN | denotes | in |
| T2764 | 578-580 | NN | denotes | ES |
| T2765 | 581-586 | NNS | denotes | cells |
| T2766 | 586-588 | , | denotes | , |
| R262 | T2695 | T2690 | advmod | vivo,from |
| R264 | T2696 | T2689 | cc | and,phenotypes |
| R266 | T2697 | T2698 | compound | transfection,data |
| R267 | T2698 | T2689 | conj | data,phenotypes |
| R269 | T2699 | T2685 | auxpass | were,observed |
| R271 | T2701 | T2702 | punct | [,1 |
| R272 | T2702 | T2685 | parataxis | 1,observed |
| R273 | T2703 | T2702 | advmod | e.g.,1 |
| R275 | T2704 | T2702 | nmod | Refs,1 |
| R276 | T2705 | T2702 | punct | (,1 |
| R278 | T2706 | T2707 | punct | –,5 |
| R279 | T2707 | T2702 | prep | 5,1 |
| R280 | T2708 | T2702 | punct | ),1 |
| R282 | T2709 | T2702 | punct | ],1 |
| R284 | T2710 | T2700 | punct | ", ",need |
| R286 | T2711 | T2712 | advmod | more,targeted |
| R287 | T2712 | T2713 | amod | targeted,mutations |
| R289 | T2713 | T2700 | nsubj | mutations,need |
| R290 | T2714 | T2715 | aux | to,generated |
| R291 | T2715 | T2700 | xcomp | generated,need |
| R292 | T2716 | T2715 | auxpass | be,generated |
| R294 | T2717 | T2715 | cc | and,generated |
| R295 | T2718 | T2715 | conj | analyzed,generated |
| R297 | T2719 | T2718 | prep | in,analyzed |
| R298 | T2720 | T2721 | amod | multiple,tissues |
| R299 | T2721 | T2719 | pobj | tissues,in |
| R300 | T2722 | T2723 | aux | to,formulate |
| R301 | T2723 | T2718 | advcl | formulate,analyzed |
| R302 | T2724 | T2725 | advmod | more,accurate |
| R304 | T2725 | T2726 | amod | accurate,models |
| R306 | T2726 | T2723 | dobj | models,formulate |
| R307 | T2727 | T2726 | prep | of,models |
| R308 | T2728 | T2729 | compound | p53,regulation |
| R309 | T2729 | T2727 | pobj | regulation,of |
| R310 | T2730 | T2700 | punct | .,need |
| R312 | T2732 | T2733 | advmod | However,is |
| R314 | T2734 | T2733 | punct | ", ",is |
| R315 | T2735 | T2733 | csubj | using,is |
| R317 | T2736 | T2737 | amod | homologous,recombination |
| R319 | T2737 | T2735 | dobj | recombination,using |
| R320 | T2738 | T2735 | prep | in,using |
| R322 | T2739 | T2740 | compound | ES,cells |
| R323 | T2740 | T2738 | pobj | cells,in |
| R324 | T2741 | T2742 | aux | to,generate |
| R326 | T2742 | T2735 | advcl | generate,using |
| R327 | T2743 | T2744 | amod | mutant,mice |
| R328 | T2744 | T2742 | dobj | mice,generate |
| R329 | T2745 | T2746 | det | an,method |
| R331 | T2746 | T2733 | attr | method,is |
| R332 | T2747 | T2746 | amod | inefficient,method |
| R333 | T2748 | T2747 | punct | ", ",inefficient |
| R335 | T2749 | T2747 | conj | slow,inefficient |
| R336 | T2750 | T2749 | cc | and,slow |
| R338 | T2751 | T2749 | conj | expensive,slow |
| R339 | T2752 | T2753 | mark | because,occurs |
| R340 | T2753 | T2733 | advcl | occurs,is |
| R342 | T2754 | T2755 | punct | (,i |
| R343 | T2755 | T2753 | meta | i,occurs |
| R344 | T2756 | T2755 | punct | ),i |
| R345 | T2757 | T2758 | amod | homologous,recombination |
| R347 | T2758 | T2753 | nsubj | recombination,occurs |
| R348 | T2759 | T2753 | advmod | typically,occurs |
| R349 | T2760 | T2753 | prep | at,occurs |
| R351 | T2761 | T2762 | amod | low,frequency |
| R352 | T2762 | T2760 | pobj | frequency,at |
| R353 | T2763 | T2753 | prep | in,occurs |
| R354 | T2764 | T2765 | compound | ES,cells |
| R355 | T2765 | T2763 | pobj | cells,in |
| R356 | T2766 | T2753 | punct | ", ",occurs |
| R380 | T2668 | T2669 | det | the,promoter |
| R382 | T2669 | T2667 | pobj | promoter,from |
| R385 | T2670 | T2669 | amod | endogenous,promoter |
| R398 | T2673 | T2674 | amod | physiological,levels |
| R401 | T2674 | T2672 | dobj | levels,ensuring |
| R404 | T2675 | T2674 | compound | expression,levels |
| R405 | T2676 | T2674 | cc | and,levels |
| R407 | T2677 | T2678 | amod | correct,profiles |
| R410 | T2678 | T2674 | conj | profiles,levels |
| R414 | T2679 | T2680 | amod | spatio,temporal |
| R417 | T2680 | T2678 | amod | temporal,profiles |
| R421 | T2681 | T2680 | punct | -,temporal |
| R428 | T2684 | T2685 | mark | As,observed |
| R434 | T2685 | T2700 | advcl | observed,need |
| R438 | T2686 | T2687 | amod | significant,differences |
| R440 | T2687 | T2685 | nsubjpass | differences,observed |
| R443 | T2688 | T2687 | prep | between,differences |
| R447 | T2689 | T2688 | pobj | phenotypes,between |
| R451 | T2690 | T2689 | prep | from,phenotypes |
| R455 | T2691 | T2692 | amod | targeted,mutants |
| R461 | T2692 | T2690 | pobj | mutants,from |
| R463 | T2693 | T2692 | compound | p53,mutants |
| R467 | T2694 | T2695 | advmod | in,vivo |