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PMC:149366 / 0-5567 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1846 0-5 NN denotes Brn3c
T2767 0-5 NN denotes Brn3c
T187 0-5 NN denotes Brn3c
T189 0-98 sentence denotes Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation
T188 6-10 JJ denotes null
T1847 6-10 JJ denotes null
T2769 6-10 JJ denotes null
T191 11-17 JJ denotes mutant
T190 18-22 NNS denotes mice
T192 23-27 VBP denotes show
T193 28-32 JJ denotes long
T195 32-33 HYPH denotes -
T194 33-37 NN denotes term
T197 37-39 , denotes ,
T198 39-49 JJ denotes incomplete
T196 50-59 NN denotes retention
T199 60-62 IN denotes of
T200 63-67 DT denotes some
T202 68-76 JJ denotes afferent
T203 77-82 JJ denotes inner
T204 83-86 NN denotes ear
T201 87-98 NN denotes innervation
T205 98-99 sentence denotes
T206 109-119 sentence denotes Background
T207 109-119 NN denotes Background
T208 119-258 sentence denotes Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates.
T209 120-124 NNS denotes Ears
T211 125-127 IN denotes of
T212 128-133 NN denotes Brn3c
T214 134-138 JJ denotes null
T213 139-146 NNS denotes mutants
T210 147-154 VBP denotes develop
T215 155-163 JJ denotes immature
T217 164-168 NN denotes hair
T216 169-174 NNS denotes cells
T218 174-176 , denotes ,
T219 176-188 JJ denotes identifiable
T220 189-193 RB denotes only
T221 194-196 IN denotes by
T222 197-204 JJ denotes certain
T224 205-214 JJ denotes molecular
T223 215-222 NNS denotes markers
T225 222-224 , denotes ,
T226 224-227 CC denotes and
T227 228-235 VBP denotes undergo
T228 236-245 NN denotes apoptosis
T229 246-248 IN denotes in
T230 249-257 NNS denotes neonates
T231 257-258 . denotes .
T232 258-400 sentence denotes This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development.
T233 259-263 DT denotes This
T235 264-271 JJ denotes partial
T234 272-283 NN denotes development
T237 284-286 IN denotes of
T238 287-291 NN denotes hair
T239 292-297 NNS denotes cells
T240 298-303 MD denotes could
T236 304-308 VB denotes lead
T241 309-311 IN denotes to
T242 312-318 JJ denotes enough
T244 319-331 NN denotes neurotrophin
T243 332-342 NN denotes expression
T245 343-345 TO denotes to
T246 346-353 VB denotes sustain
T247 354-361 JJ denotes sensory
T248 362-369 NNS denotes neurons
T249 370-377 IN denotes through
T250 378-387 JJ denotes embryonic
T251 388-399 NN denotes development
T252 399-400 . denotes .
T253 400-518 sentence denotes We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins.
T254 401-403 PRP denotes We
T256 404-408 VBP denotes have
T257 409-418 RB denotes therefore
T255 419-431 VBN denotes investigated
T258 432-434 IN denotes in
T259 435-440 DT denotes these
T260 441-448 NNS denotes mutants
T261 449-452 DT denotes the
T262 453-461 NNS denotes patterns
T263 462-464 IN denotes of
T264 465-476 NN denotes innervation
T265 477-480 CC denotes and
T266 481-483 IN denotes of
T267 484-494 NN denotes expression
T268 495-497 IN denotes of
T269 498-503 JJ denotes known
T270 504-517 NNS denotes neurotrophins
T271 517-518 . denotes .
T272 518-527 sentence denotes Results
T273 520-527 NNS denotes Results
T274 527-729 sentence denotes At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations.
T275 528-530 IN denotes At
T277 531-536 NN denotes birth
T278 537-542 EX denotes there
T276 543-545 VBZ denotes is
T279 546-547 DT denotes a
T281 548-555 VBN denotes limited
T280 556-566 NN denotes expression
T282 567-569 IN denotes of
T283 570-574 NN denotes BDNF
T284 575-578 CC denotes and
T285 579-581 NN denotes NT
T286 581-582 HYPH denotes -
T287 582-583 CD denotes 3
T288 584-586 IN denotes in
T289 587-590 DT denotes the
T291 591-597 JJ denotes mutant
T292 598-605 JJ denotes sensory
T290 606-615 NNS denotes epithelia
T293 616-619 CC denotes and
T294 620-623 NN denotes DiI
T295 624-631 NN denotes tracing
T296 632-637 VBZ denotes shows
T297 638-640 DT denotes no
T299 641-649 JJ denotes specific
T298 650-659 NN denotes reduction
T300 660-662 IN denotes of
T301 663-672 NNS denotes afferents
T302 673-675 CC denotes or
T303 676-685 NNS denotes efferents
T304 686-690 WDT denotes that
T305 691-700 VBZ denotes resembles
T306 701-713 NN denotes neurotrophin
T308 714-718 JJ denotes null
T307 719-728 NNS denotes mutations
T309 728-729 . denotes .
T310 729-829 sentence denotes At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively.
T311 730-732 IN denotes At
T313 733-742 JJ denotes postnatal
T314 743-746 NN denotes day
T315 747-748 CD denotes 7
T316 748-749 HYPH denotes /
T317 749-750 CD denotes 8
T318 751-752 -LRB- denotes (
T319 752-754 NN denotes P7
T320 754-755 HYPH denotes /
T321 755-756 CD denotes 8
T322 756-757 -RRB- denotes )
T323 757-759 , denotes ,
T324 759-770 NN denotes innervation
T325 771-773 VBZ denotes is
T326 774-782 RB denotes severely
T312 783-790 VBN denotes reduced
T327 791-795 CC denotes both
T328 796-809 RB denotes qualitatively
T329 810-813 CC denotes and
T330 814-828 RB denotes quantitatively
T331 828-829 . denotes .
T332 829-937 sentence denotes 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base.
T333 830-831 CD denotes 1
T334 831-832 NN denotes %
T336 833-835 IN denotes of
T337 836-842 NN denotes myosin
T338 843-847 NN denotes VIIa
T340 847-848 HYPH denotes -
T339 848-856 JJ denotes positive
T342 857-865 JJ denotes immature
T343 866-870 NN denotes hair
T341 871-876 NNS denotes cells
T335 877-880 VBP denotes are
T344 881-888 JJ denotes present
T345 889-891 IN denotes in
T346 892-895 DT denotes the
T348 896-902 JJ denotes mutant
T347 903-910 NN denotes cochlea
T349 910-912 , denotes ,
T350 912-924 VBD denotes concentrated
T351 925-927 IN denotes in
T352 928-931 DT denotes the
T353 932-936 NN denotes base
T354 936-937 . denotes .
T355 937-1021 sentence denotes Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia.
T356 938-944 IN denotes Around
T357 945-947 CD denotes 20
T358 947-948 NN denotes %
T360 949-951 IN denotes of
T361 952-960 JJ denotes immature
T363 961-965 NN denotes hair
T362 966-971 NNS denotes cells
T359 972-977 VBP denotes exist
T364 978-980 IN denotes in
T365 981-984 DT denotes the
T367 985-991 JJ denotes mutant
T368 992-1002 JJ denotes vestibular
T369 1003-1010 JJ denotes sensory
T366 1011-1020 NNS denotes epithelia
T370 1020-1021 . denotes .
T371 1021-1177 sentence denotes Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia.
T372 1022-1029 IN denotes Despite
T374 1030-1034 RBR denotes more
T375 1035-1041 JJ denotes severe
T376 1042-1046 NN denotes loss
T377 1047-1049 IN denotes of
T378 1050-1054 NN denotes hair
T379 1055-1060 NNS denotes cells
T380 1061-1062 -LRB- denotes (
T382 1062-1063 CD denotes 1
T381 1063-1064 NN denotes %
T383 1065-1073 VBN denotes compared
T384 1074-1076 IN denotes to
T385 1077-1079 CD denotes 20
T386 1079-1080 NN denotes %
T387 1080-1081 -RRB- denotes )
T388 1081-1083 , denotes ,
T389 1083-1086 DT denotes the
T390 1087-1094 NN denotes cochlea
T373 1095-1102 VBZ denotes retains
T391 1103-1107 JJ denotes many
T393 1108-1112 JJR denotes more
T394 1113-1120 JJ denotes sensory
T392 1121-1128 NNS denotes neurons
T395 1129-1130 -LRB- denotes (
T397 1130-1132 CD denotes 46
T396 1132-1133 NN denotes %
T398 1134-1142 VBN denotes compared
T399 1143-1145 IN denotes to
T400 1146-1148 CD denotes 15
T401 1148-1149 NN denotes %
T402 1149-1150 -RRB- denotes )
T403 1151-1155 IN denotes than
T404 1156-1166 JJ denotes vestibular
T405 1167-1176 NNS denotes epithelia
T406 1176-1177 . denotes .
T407 1177-1336 sentence denotes Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells.
T408 1178-1182 RB denotes Even
T410 1183-1184 CD denotes 6
T411 1185-1191 NNS denotes months
T412 1192-1195 JJ denotes old
T413 1196-1202 JJ denotes mutant
T409 1203-1207 NNS denotes mice
T414 1208-1212 VBP denotes have
T415 1213-1217 DT denotes some
T416 1218-1224 NNS denotes fibers
T417 1225-1227 IN denotes to
T418 1228-1231 DT denotes all
T420 1232-1242 JJ denotes vestibular
T421 1243-1250 JJ denotes sensory
T419 1251-1260 NNS denotes epithelia
T422 1261-1264 CC denotes and
T423 1265-1269 JJ denotes many
T424 1270-1274 JJR denotes more
T425 1275-1277 IN denotes to
T426 1278-1281 DT denotes the
T428 1282-1290 JJ denotes cochlear
T427 1291-1295 NN denotes apex
T429 1296-1301 WDT denotes which
T430 1302-1307 VBZ denotes lacks
T431 1308-1315 NN denotes MyoVIIa
T432 1316-1324 JJ denotes positive
T434 1325-1329 NN denotes hair
T433 1330-1335 NNS denotes cells
T435 1335-1336 . denotes .
T436 1336-1499 sentence denotes Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections.
T437 1337-1350 RB denotes Topologically
T438 1351-1360 VBN denotes organized
T440 1361-1368 JJ denotes central
T441 1369-1376 NN denotes cochlea
T439 1377-1388 NNS denotes projections
T442 1389-1394 VBP denotes exist
T443 1395-1397 RB denotes at
T444 1398-1403 RBS denotes least
T445 1404-1409 IN denotes until
T446 1410-1412 NN denotes P8
T447 1412-1414 , denotes ,
T448 1414-1424 VBG denotes suggesting
T449 1425-1429 IN denotes that
T451 1430-1440 JJ denotes functional
T453 1441-1445 NN denotes hair
T452 1446-1451 NNS denotes cells
T454 1452-1455 VBP denotes are
T455 1456-1459 RB denotes not
T450 1460-1468 VBN denotes required
T456 1469-1471 TO denotes to
T457 1472-1481 VB denotes establish
T458 1482-1486 JJ denotes such
T459 1487-1498 NNS denotes projections
T460 1498-1499 . denotes .
T461 1499-1511 sentence denotes Conclusion
T462 1501-1511 NN denotes Conclusion
T463 1511-1669 sentence denotes The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth.
T464 1512-1515 DT denotes The
T466 1516-1523 VBN denotes limited
T465 1524-1534 NN denotes expression
T468 1535-1537 IN denotes of
T469 1538-1551 NNS denotes neurotrophins
T470 1552-1554 IN denotes in
T471 1555-1558 DT denotes the
T472 1559-1566 NN denotes cochlea
T473 1567-1569 IN denotes of
T474 1570-1575 NN denotes Brn3c
T475 1576-1580 JJ denotes null
T476 1581-1585 NNS denotes mice
T467 1586-1594 VBZ denotes suffices
T477 1595-1597 TO denotes to
T478 1598-1605 VB denotes support
T479 1606-1610 JJ denotes many
T481 1611-1618 JJ denotes sensory
T480 1619-1626 NNS denotes neurons
T482 1626-1628 , denotes ,
T483 1628-1640 RB denotes particularly
T484 1641-1643 IN denotes in
T485 1644-1647 DT denotes the
T486 1648-1655 NN denotes cochlea
T487 1655-1657 , denotes ,
T488 1657-1662 IN denotes until
T489 1663-1668 NN denotes birth
T490 1668-1669 . denotes .
T491 1669-1758 sentence denotes The molecular nature of the long term survival of apical spiral neurons remains unclear.
T492 1670-1673 DT denotes The
T494 1674-1683 JJ denotes molecular
T493 1684-1690 NN denotes nature
T496 1691-1693 IN denotes of
T497 1694-1697 DT denotes the
T499 1698-1702 JJ denotes long
T500 1703-1707 NN denotes term
T498 1708-1716 NN denotes survival
T501 1717-1719 IN denotes of
T502 1720-1726 JJ denotes apical
T503 1727-1733 JJ denotes spiral
T504 1734-1741 NNS denotes neurons
T495 1742-1749 VBZ denotes remains
T505 1750-1757 JJ denotes unclear
T506 1757-1758 . denotes .
T820 1771-1776 NN denotes Brn3c
T821 1777-1779 VBZ denotes is
T822 1780-1781 DT denotes a
T824 1782-1785 NN denotes POU
T825 1786-1792 NN denotes domain
T823 1793-1799 NN denotes factor
T826 1800-1804 WDT denotes that
T827 1805-1807 VBZ denotes is
T828 1808-1815 JJ denotes crucial
T829 1816-1819 IN denotes for
T830 1820-1825 JJ denotes inner
T831 1826-1829 JJ denotes ear
T833 1830-1834 NN denotes hair
T834 1835-1839 NN denotes cell
T832 1840-1851 NN denotes development
T835 1851-1852 . denotes .
T836 1852-1913 sentence denotes Targeted null Brn3c mutants have no mature hair cells [1,2].
T837 1853-1861 VBN denotes Targeted
T839 1862-1866 JJ denotes null
T840 1867-1872 NN denotes Brn3c
T838 1873-1880 NNS denotes mutants
T841 1881-1885 VBP denotes have
T842 1886-1888 DT denotes no
T844 1889-1895 JJ denotes mature
T845 1896-1900 NN denotes hair
T843 1901-1906 NNS denotes cells
T846 1907-1908 -LRB- denotes [
T848 1908-1909 CD denotes 1
T849 1909-1910 , denotes ,
T847 1910-1911 CD denotes 2
T850 1911-1912 -RRB- denotes ]
T851 1912-1913 . denotes .
T852 1913-2092 sentence denotes Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3].
T853 1914-1919 NN denotes Close
T854 1920-1931 NN denotes examination
T856 1932-1935 VBZ denotes has
T855 1936-1944 VBN denotes revealed
T857 1945-1949 IN denotes that
T859 1950-1954 DT denotes some
T861 1955-1956 `` denotes '
T862 1956-1964 JJ denotes immature
T863 1964-1965 '' denotes '
T864 1966-1970 NN denotes hair
T860 1971-1976 NNS denotes cells
T858 1977-1981 VBP denotes form
T865 1982-1984 IN denotes in
T866 1985-1990 NN denotes Brn3c
T868 1991-1995 JJ denotes null
T867 1996-2003 NNS denotes mutants
T869 2004-2007 CC denotes and
T870 2008-2015 VBP denotes express
T871 2016-2024 JJ denotes cellular
T872 2025-2032 NNS denotes markers
T873 2033-2037 JJ denotes such
T874 2038-2040 IN denotes as
T875 2041-2047 NN denotes Myosin
T876 2048-2050 NN denotes VI
T877 2051-2054 CC denotes and
T878 2055-2059 NN denotes VIIa
T879 2059-2061 , denotes ,
T880 2061-2071 NN denotes calretinin
T881 2072-2075 CC denotes and
T882 2076-2087 NN denotes parvalbumin
T883 2088-2089 -LRB- denotes [
T884 2089-2090 CD denotes 3
T885 2090-2091 -RRB- denotes ]
T886 2091-2092 . denotes .
T887 2092-2188 sentence denotes Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3].
T888 2093-2104 RB denotes Furthermore
T890 2104-2106 , denotes ,
T891 2106-2111 DT denotes these
T893 2112-2120 JJ denotes immature
T894 2121-2125 NN denotes hair
T892 2126-2131 NNS denotes cells
T895 2132-2134 IN denotes of
T896 2135-2140 NN denotes Brn3c
T898 2141-2145 JJ denotes null
T897 2146-2153 NNS denotes mutants
T889 2154-2161 VBP denotes undergo
T899 2162-2171 NN denotes apoptosis
T900 2172-2174 IN denotes in
T901 2175-2183 NNS denotes neonates
T902 2184-2185 -LRB- denotes [
T903 2185-2186 CD denotes 3
T904 2186-2187 -RRB- denotes ]
T905 2187-2188 . denotes .
T906 2188-2361 sentence denotes Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]).
T907 2189-2199 JJ denotes Consistent
T909 2200-2204 IN denotes with
T910 2205-2207 DT denotes an
T912 2208-2216 JJ denotes apparent
T911 2217-2224 NN denotes absence
T913 2225-2227 IN denotes of
T914 2228-2234 JJ denotes mature
T916 2235-2239 NN denotes hair
T915 2240-2245 NNS denotes cells
T917 2245-2247 , denotes ,
T918 2247-2254 JJ denotes initial
T919 2255-2259 NN denotes work
T908 2260-2269 VBD denotes suggested
T920 2270-2274 IN denotes that
T922 2275-2278 DT denotes all
T923 2279-2289 JJ denotes vestibular
T924 2290-2293 CC denotes and
T925 2294-2298 DT denotes most
T926 2299-2305 JJ denotes spiral
T928 2306-2314 NN denotes ganglion
T927 2315-2320 NNS denotes cells
T929 2321-2324 VBP denotes are
T921 2325-2329 VBN denotes lost
T930 2330-2332 IN denotes by
T931 2333-2342 JJ denotes postnatal
T932 2343-2346 NN denotes day
T933 2347-2349 CD denotes 14
T934 2350-2351 -LRB- denotes (
T935 2351-2354 NN denotes P14
T936 2354-2355 : denotes ;
T937 2356-2357 -LRB- denotes [
T938 2357-2358 CD denotes 1
T939 2358-2359 -RRB- denotes ]
T940 2359-2360 -RRB- denotes )
T941 2360-2361 . denotes .
T942 2361-2506 sentence denotes However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost.
T943 2362-2369 RB denotes However
T945 2369-2371 , denotes ,
T946 2371-2375 RBR denotes more
T948 2376-2384 JJ denotes detailed
T947 2385-2399 NN denotes quantification
T949 2400-2402 IN denotes by
T950 2403-2409 NNS denotes others
T951 2410-2411 -LRB- denotes [
T952 2411-2412 CD denotes 3
T953 2412-2413 -RRB- denotes ]
T944 2414-2422 VBD denotes reported
T954 2423-2427 IN denotes that
T956 2428-2430 IN denotes at
T957 2431-2433 NN denotes P4
T958 2434-2439 IN denotes about
T959 2440-2442 CD denotes 77
T960 2442-2443 NN denotes %
T961 2444-2446 IN denotes of
T962 2447-2457 JJ denotes vestibular
T963 2458-2465 NNS denotes neurons
T964 2466-2469 CC denotes and
T965 2470-2474 RB denotes only
T966 2475-2477 CD denotes 29
T967 2477-2478 NN denotes %
T968 2479-2481 IN denotes of
T969 2482-2488 JJ denotes spiral
T970 2489-2496 NNS denotes neurons
T971 2497-2500 VBP denotes are
T955 2501-2505 VBN denotes lost
T972 2505-2506 . denotes .
T973 2506-2577 sentence denotes It was suggested that there is possibly a complete loss in adults [3].
T974 2507-2509 PRP denotes It
T976 2510-2513 VBD denotes was
T975 2514-2523 VBN denotes suggested
T977 2524-2528 IN denotes that
T979 2529-2534 EX denotes there
T978 2535-2537 VBZ denotes is
T980 2538-2546 RB denotes possibly
T981 2547-2548 DT denotes a
T983 2549-2557 JJ denotes complete
T982 2558-2562 NN denotes loss
T984 2563-2565 IN denotes in
T985 2566-2572 NNS denotes adults
T986 2573-2574 -LRB- denotes [
T987 2574-2575 CD denotes 3
T988 2575-2576 -RRB- denotes ]
T989 2576-2577 . denotes .
T990 2577-2711 sentence denotes Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants.
T991 2578-2583 RB denotes Other
T993 2584-2588 IN denotes than
T994 2589-2594 DT denotes these
T996 2595-2606 JJ denotes preliminary
T995 2607-2617 NNS denotes statements
T997 2617-2619 , denotes ,
T998 2619-2621 DT denotes no
T999 2622-2626 NN denotes data
T992 2627-2633 VBZ denotes exists
T1000 2634-2644 VBG denotes concerning
T1001 2645-2648 DT denotes the
T1003 2649-2657 JJ denotes detailed
T1002 2658-2665 NN denotes pattern
T1004 2666-2668 IN denotes of
T1005 2669-2673 NN denotes loss
T1006 2674-2676 IN denotes of
T1007 2677-2688 NN denotes innervation
T1008 2689-2691 IN denotes in
T1009 2692-2697 NN denotes Brn3c
T1010 2698-2702 JJ denotes null
T1011 2703-2710 NNS denotes mutants
T1012 2710-2711 . denotes .
T1013 2711-2930 sentence denotes The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond.
T1014 2712-2715 DT denotes The
T1016 2716-2723 JJ denotes initial
T1015 2724-2735 NN denotes development
T1018 2736-2739 CC denotes and
T1019 2740-2747 JJ denotes partial
T1020 2748-2763 NN denotes differentiation
T1021 2764-2766 IN denotes of
T1022 2767-2771 NN denotes hair
T1023 2772-2777 NNS denotes cells
T1024 2778-2780 IN denotes in
T1025 2781-2786 NN denotes Brn3c
T1026 2787-2794 NNS denotes mutants
T1027 2795-2800 MD denotes could
T1028 2801-2809 RB denotes possibly
T1017 2810-2814 VB denotes lead
T1029 2815-2817 IN denotes to
T1030 2818-2822 DT denotes some
T1032 2823-2835 NN denotes neurotrophin
T1031 2836-2846 NN denotes expression
T1033 2847-2849 IN denotes in
T1034 2850-2855 DT denotes these
T1035 2856-2861 NNS denotes cells
T1036 2862-2864 TO denotes to
T1037 2865-2872 VB denotes sustain
T1038 2873-2880 JJ denotes sensory
T1039 2881-2888 NNS denotes neurons
T1040 2889-2896 IN denotes through
T1041 2897-2906 JJ denotes embryonic
T1042 2907-2918 NN denotes development
T1043 2919-2922 CC denotes and
T1044 2923-2929 RB denotes beyond
T1045 2929-2930 . denotes .
T1046 2930-3130 sentence denotes Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5].
T1047 2931-2935 NNS denotes Data
T1049 2936-2938 IN denotes on
T1050 2939-2946 JJ denotes various
T1052 2947-2953 JJ denotes single
T1054 2954-2957 CC denotes and
T1055 2958-2966 NN denotes compound
T1053 2967-2979 NN denotes neurotrophin
T1056 2980-2984 JJ denotes null
T1051 2985-2992 NNS denotes mutants
T1057 2993-2997 VBP denotes have
T1048 2998-3003 VBN denotes shown
T1058 3004-3008 IN denotes that
T1060 3009-3012 DT denotes the
T1061 3013-3017 NN denotes loss
T1062 3018-3020 IN denotes of
T1063 3021-3022 DT denotes a
T1065 3023-3031 JJ denotes specific
T1064 3032-3044 NN denotes neurotrophin
T1059 3045-3050 VBZ denotes leads
T1066 3051-3053 IN denotes to
T1067 3054-3067 RB denotes topologically
T1068 3068-3078 JJ denotes restricted
T1069 3079-3083 NN denotes loss
T1070 3084-3086 IN denotes of
T1071 3087-3094 JJ denotes sensory
T1072 3095-3102 NNS denotes neurons
T1073 3103-3105 IN denotes in
T1074 3106-3109 DT denotes the
T1076 3110-3119 JJ denotes embryonic
T1075 3120-3123 NN denotes ear
T1077 3124-3125 -LRB- denotes [
T1079 3125-3126 CD denotes 4
T1080 3126-3127 , denotes ,
T1078 3127-3128 CD denotes 5
T1081 3128-3129 -RRB- denotes ]
T1082 3129-3130 . denotes .
T1083 3130-3258 sentence denotes Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells.
T1084 3131-3135 JJ denotes Such
T1086 3136-3145 JJ denotes selective
T1085 3146-3150 NN denotes loss
T1088 3151-3153 IN denotes in
T1089 3154-3159 NN denotes Brn3c
T1091 3160-3164 JJ denotes null
T1090 3165-3172 NNS denotes mutants
T1092 3173-3178 MD denotes would
T1093 3179-3188 RB denotes therefore
T1087 3189-3197 VB denotes indicate
T1094 3198-3207 NN denotes reduction
T1095 3208-3210 IN denotes of
T1096 3211-3212 DT denotes a
T1098 3213-3221 JJ denotes specific
T1097 3222-3234 NN denotes neurotrophin
T1099 3235-3237 IN denotes in
T1100 3238-3246 JJ denotes immature
T1102 3247-3251 NN denotes hair
T1101 3252-3257 NNS denotes cells
T1103 3257-3258 . denotes .
T1104 3258-3399 sentence denotes Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7].
T1105 3259-3267 RB denotes Moreover
T1107 3267-3269 , denotes ,
T1108 3269-3275 JJ denotes recent
T1109 3276-3280 NN denotes work
T1106 3281-3286 VBZ denotes shows
T1110 3287-3291 IN denotes that
T1112 3292-3294 IN denotes in
T1113 3295-3302 NNS denotes embryos
T1114 3303-3305 NN denotes NT
T1115 3305-3306 HYPH denotes -
T1116 3306-3307 CD denotes 3
T1117 3308-3310 VBZ denotes is
T1118 3311-3320 RB denotes primarily
T1111 3321-3330 VBN denotes expressed
T1119 3331-3333 IN denotes in
T1120 3334-3344 VBG denotes supporting
T1121 3345-3350 NNS denotes cells
T1122 3350-3352 , denotes ,
T1123 3352-3358 VBG denotes moving
T1124 3359-3363 RB denotes only
T1125 3364-3370 IN denotes around
T1126 3371-3376 NN denotes birth
T1127 3377-3381 IN denotes into
T1128 3382-3386 NN denotes hair
T1129 3387-3392 NNS denotes cells
T1130 3393-3394 -LRB- denotes [
T1132 3394-3395 CD denotes 6
T1133 3395-3396 , denotes ,
T1131 3396-3397 CD denotes 7
T1134 3397-3398 -RRB- denotes ]
T1135 3398-3399 . denotes .
T1136 3399-3677 sentence denotes In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place.
T1137 3400-3402 IN denotes In
T1139 3403-3407 NN denotes fact
T1140 3407-3409 , denotes ,
T1141 3409-3412 DT denotes the
T1143 3413-3422 JJ denotes selective
T1142 3423-3427 NN denotes loss
T1144 3428-3430 IN denotes of
T1145 3431-3441 JJ denotes vestibular
T1146 3442-3444 IN denotes as
T1147 3445-3453 VBN denotes compared
T1148 3454-3456 IN denotes to
T1149 3457-3465 JJ denotes cochlear
T1150 3466-3473 JJ denotes sensory
T1151 3474-3481 NNS denotes neurons
T1152 3482-3483 -LRB- denotes (
T1154 3483-3485 CD denotes 77
T1153 3485-3486 NN denotes %
T1155 3487-3493 CC denotes versus
T1156 3494-3496 CD denotes 29
T1157 3496-3497 NN denotes %
T1158 3497-3498 : denotes ;
T1159 3499-3500 -LRB- denotes [
T1160 3500-3501 CD denotes 3
T1161 3501-3502 -RRB- denotes ]
T1162 3502-3503 -RRB- denotes )
T1138 3504-3512 VBZ denotes suggests
T1163 3513-3517 IN denotes that
T1165 3518-3520 NN denotes NT
T1167 3520-3521 HYPH denotes -
T1168 3521-3522 CD denotes 3
T1166 3523-3533 NN denotes expression
T1169 3534-3537 MD denotes may
T1164 3538-3540 VB denotes be
T1170 3541-3545 RBR denotes less
T1171 3546-3559 VBN denotes downregulated
T1172 3560-3562 IN denotes in
T1173 3563-3568 NN denotes Brn3c
T1175 3569-3573 JJ denotes null
T1174 3574-3581 NNS denotes mutants
T1176 3582-3586 IN denotes than
T1177 3587-3591 NN denotes BDNF
T1178 3592-3593 -LRB- denotes [
T1180 3593-3594 CD denotes 6
T1181 3594-3595 , denotes ,
T1182 3595-3596 CD denotes 8
T1183 3596-3597 , denotes ,
T1179 3597-3598 CD denotes 9
T1184 3598-3599 -RRB- denotes ]
T1185 3599-3601 , denotes ,
T1186 3601-3609 VBN denotes provided
T1187 3610-3614 IN denotes that
T1189 3615-3617 RB denotes at
T1190 3618-3623 RBS denotes least
T1192 3624-3628 DT denotes some
T1191 3629-3644 NN denotes differentiation
T1193 3645-3647 IN denotes of
T1194 3648-3658 VBG denotes supporting
T1195 3659-3664 NNS denotes cells
T1188 3665-3670 VBZ denotes takes
T1196 3671-3676 NN denotes place
T1197 3676-3677 . denotes .
T1198 3677-3830 sentence denotes In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11].
T1199 3678-3680 IN denotes In
T1201 3681-3684 DT denotes the
T1202 3685-3688 NN denotes ear
T1203 3689-3690 -LRB- denotes [
T1204 3690-3691 CD denotes 4
T1205 3691-3692 -RRB- denotes ]
T1206 3693-3695 RB denotes as
T1208 3696-3700 RB denotes well
T1207 3701-3703 IN denotes as
T1209 3704-3713 RB denotes elsewhere
T1211 3714-3715 -LRB- denotes [
T1210 3715-3717 CD denotes 10
T1212 3717-3718 -RRB- denotes ]
T1213 3719-3732 NNS denotes neurotrophins
T1214 3733-3736 VBP denotes are
T1215 3737-3750 RB denotes progressively
T1200 3751-3764 VBN denotes downregulated
T1216 3765-3767 IN denotes in
T1217 3768-3777 JJ denotes postnatal
T1218 3778-3785 NNS denotes mammals
T1219 3786-3789 CC denotes and
T1220 3790-3798 RB denotes possibly
T1221 3799-3807 VBN denotes replaced
T1222 3808-3810 IN denotes by
T1223 3811-3816 JJ denotes other
T1224 3817-3824 NNS denotes factors
T1225 3825-3826 -LRB- denotes [
T1226 3826-3828 CD denotes 11
T1227 3828-3829 -RRB- denotes ]
T1228 3829-3830 . denotes .
T1229 3830-3954 sentence denotes We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF.
T1230 3831-3833 PRP denotes We
T1232 3834-3838 VBP denotes have
T1231 3839-3851 VBN denotes investigated
T1233 3852-3854 IN denotes in
T1234 3855-3861 NN denotes detail
T1235 3862-3865 DT denotes the
T1236 3866-3873 NN denotes pattern
T1237 3874-3876 IN denotes of
T1238 3877-3888 NN denotes innervation
T1239 3889-3891 IN denotes in
T1240 3892-3895 DT denotes the
T1242 3896-3901 NN denotes Brn3c
T1241 3902-3909 NNS denotes mutants
T1243 3909-3911 , denotes ,
T1244 3911-3913 RB denotes as
T1246 3914-3918 RB denotes well
T1245 3919-3921 IN denotes as
T1247 3922-3925 DT denotes the
T1248 3926-3936 NN denotes expression
T1249 3937-3939 IN denotes of
T1250 3940-3942 NN denotes NT
T1251 3942-3943 HYPH denotes -
T1252 3943-3944 CD denotes 3
T1253 3945-3948 CC denotes and
T1254 3949-3953 NN denotes BDNF
T1255 3953-3954 . denotes .
T1256 3954-4145 sentence denotes We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals.
T1257 3955-3957 PRP denotes We
T1258 3958-3962 VBP denotes want
T1259 3963-3965 TO denotes to
T1260 3966-3974 VB denotes evaluate
T1261 3975-3976 DT denotes a
T1263 3977-3985 JJ denotes possible
T1262 3986-3997 NN denotes correlation
T1264 3998-4005 IN denotes between
T1265 4006-4009 DT denotes the
T1266 4010-4018 NN denotes topology
T1267 4019-4021 IN denotes of
T1268 4022-4029 JJ denotes sensory
T1269 4030-4036 NN denotes neuron
T1270 4037-4041 NN denotes loss
T1271 4042-4045 CC denotes and
T1272 4046-4053 NN denotes absence
T1273 4054-4056 IN denotes of
T1274 4057-4058 DT denotes a
T1276 4059-4067 JJ denotes specific
T1275 4068-4080 NN denotes neurotrophin
T1277 4081-4083 CC denotes or
T1278 4084-4095 JJ denotes topological
T1279 4096-4100 NN denotes loss
T1280 4101-4103 IN denotes of
T1281 4104-4108 NN denotes hair
T1282 4109-4114 NNS denotes cells
T1283 4115-4117 IN denotes at
T1284 4118-4123 NN denotes birth
T1285 4124-4127 CC denotes and
T1286 4128-4130 IN denotes in
T1287 4131-4136 JJR denotes older
T1288 4137-4144 NNS denotes animals
T1289 4144-4145 . denotes .
T1290 4145-4271 sentence denotes This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12].
T1291 4146-4150 DT denotes This
T1292 4151-4162 NN denotes information
T1294 4163-4168 MD denotes could
T1293 4169-4171 VB denotes be
T1295 4172-4181 JJ denotes important
T1296 4182-4185 IN denotes for
T1297 4186-4188 DT denotes an
T1299 4189-4191 IN denotes in
T1300 4191-4192 HYPH denotes -
T1301 4192-4197 NN denotes depth
T1298 4198-4208 NN denotes evaluation
T1302 4209-4211 IN denotes of
T1303 4212-4215 DT denotes the
T1305 4216-4221 JJ denotes human
T1304 4222-4230 NN denotes deafness
T1306 4231-4238 VBN denotes related
T1307 4239-4241 IN denotes to
T1308 4242-4245 DT denotes the
T1310 4246-4252 NN denotes Pou4f3
T1309 4253-4257 NN denotes gene
T1311 4257-4259 , denotes ,
T1312 4259-4265 NN denotes DFNA15
T1313 4266-4267 -LRB- denotes [
T1314 4267-4269 CD denotes 12
T1315 4269-4270 -RRB- denotes ]
T1316 4270-4271 . denotes .
T1317 4271-4420 sentence denotes We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice.
T1318 4272-4274 PRP denotes We
T1319 4275-4281 VBP denotes report
T1320 4282-4286 RB denotes here
T1321 4287-4291 JJ denotes long
T1322 4292-4296 NN denotes term
T1323 4297-4306 NN denotes retention
T1324 4307-4309 IN denotes of
T1325 4310-4318 JJ denotes cochlear
T1327 4319-4326 JJ denotes sensory
T1326 4327-4334 NNS denotes neurons
T1328 4335-4338 IN denotes for
T1329 4339-4341 RB denotes at
T1331 4342-4347 RBS denotes least
T1330 4348-4349 CD denotes 6
T1332 4350-4356 NNS denotes months
T1333 4356-4358 , denotes ,
T1334 4358-4360 IN denotes in
T1336 4361-4371 JJ denotes particular
T1335 4372-4374 IN denotes in
T1337 4375-4378 DT denotes the
T1339 4379-4387 JJ denotes cochlear
T1338 4388-4392 NN denotes apex
T1340 4392-4394 , denotes ,
T1341 4394-4396 IN denotes in
T1342 4397-4402 NN denotes Brn3c
T1343 4403-4407 JJ denotes null
T1345 4408-4414 JJ denotes mutant
T1344 4415-4419 NNS denotes mice
T1346 4419-4420 . denotes .
T1347 4420-4639 sentence denotes This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea.
T1348 4421-4425 DT denotes This
T1349 4426-4435 NN denotes retention
T1351 4436-4438 IN denotes of
T1352 4439-4448 NNS denotes afferents
T1353 4449-4452 CC denotes and
T1354 4453-4462 NNS denotes efferents
T1350 4463-4465 VBZ denotes is
T1355 4466-4475 JJ denotes unrelated
T1356 4476-4478 IN denotes to
T1357 4479-4483 NN denotes hair
T1358 4484-4488 NN denotes cell
T1359 4489-4504 NN denotes differentiation
T1360 4505-4507 IN denotes as
T1362 4508-4511 RB denotes not
T1364 4512-4516 RB denotes even
T1365 4517-4525 JJ denotes immature
T1366 4526-4530 NN denotes hair
T1363 4531-4536 NNS denotes cells
T1367 4537-4540 MD denotes can
T1368 4541-4543 VB denotes be
T1361 4544-4552 VBN denotes detected
T1369 4553-4555 IN denotes at
T1370 4556-4561 JJ denotes early
T1372 4562-4571 JJ denotes postnatal
T1371 4572-4578 NNS denotes stages
T1373 4579-4583 IN denotes with
T1374 4584-4590 NN denotes MyoVII
T1375 4591-4610 NN denotes immunocytochemistry
T1376 4611-4613 IN denotes in
T1377 4614-4618 DT denotes this
T1378 4619-4623 NN denotes part
T1379 4624-4626 IN denotes of
T1380 4627-4630 DT denotes the
T1381 4631-4638 NN denotes cochlea
T1382 4638-4639 . denotes .
T1383 4639-4797 sentence denotes This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4].
T1384 4640-4644 DT denotes This
T1385 4645-4654 NN denotes retention
T1387 4655-4657 IN denotes of
T1388 4658-4664 JJ denotes apical
T1390 4665-4671 JJ denotes spiral
T1389 4672-4679 NNS denotes neurons
T1386 4680-4682 VBZ denotes is
T1391 4683-4687 RB denotes also
T1392 4688-4695 RB denotes largely
T1393 4696-4705 JJ denotes unrelated
T1394 4706-4708 IN denotes to
T1395 4709-4722 NNS denotes neurotrophins
T1396 4723-4728 WDT denotes which
T1398 4729-4732 VBP denotes are
T1397 4733-4738 VBN denotes known
T1399 4739-4741 TO denotes to
T1401 4742-4744 VB denotes be
T1400 4745-4752 VBN denotes reduced
T1402 4753-4755 IN denotes in
T1403 4756-4761 PRP$ denotes their
T1404 4762-4772 NN denotes expression
T1405 4773-4775 IN denotes in
T1406 4776-4784 JJ denotes neonatal
T1407 4785-4792 NNS denotes rodents
T1408 4793-4794 -LRB- denotes [
T1409 4794-4795 CD denotes 4
T1410 4795-4796 -RRB- denotes ]
T1411 4796-4797 . denotes .
T1476 4807-4809 TO denotes To
T1477 4810-4820 VB denotes appreciate
T1479 4821-4824 DT denotes the
T1480 4825-4832 NNS denotes effects
T1481 4833-4835 IN denotes of
T1482 4836-4839 DT denotes the
T1484 4840-4845 NN denotes Brn3c
T1485 4846-4850 JJ denotes null
T1483 4851-4859 NN denotes mutation
T1486 4860-4862 IN denotes on
T1487 4863-4866 DT denotes the
T1488 4867-4874 NN denotes pattern
T1489 4875-4877 IN denotes of
T1490 4878-4881 DT denotes the
T1492 4882-4887 JJ denotes inner
T1493 4888-4891 NN denotes ear
T1491 4892-4903 NN denotes innervation
T1494 4903-4905 , denotes ,
T1495 4905-4907 PRP denotes we
T1496 4908-4913 RB denotes first
T1478 4914-4918 VBP denotes want
T1497 4919-4921 TO denotes to
T1498 4922-4929 VB denotes present
T1499 4930-4933 DT denotes the
T1500 4934-4941 NNS denotes effects
T1501 4942-4944 IN denotes of
T1502 4945-4949 NN denotes BDNF
T1504 4950-4953 CC denotes and
T1505 4954-4956 NN denotes NT
T1506 4956-4957 HYPH denotes -
T1507 4957-4958 CD denotes 3
T1508 4959-4963 JJ denotes null
T1503 4964-4973 NNS denotes mutations
T1509 4974-4976 IN denotes at
T1510 4977-4982 NN denotes birth
T1511 4983-4984 -LRB- denotes [
T1513 4984-4985 CD denotes 6
T1514 4985-4986 , denotes ,
T1515 4986-4988 CD denotes 13
T1516 4988-4989 , denotes ,
T1512 4989-4991 CD denotes 14
T1517 4991-4992 -RRB- denotes ]
T1518 4992-4993 . denotes .
T1519 4993-5170 sentence denotes Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea.
T1520 4994-4998 JJ denotes Null
T1521 4999-5006 NNS denotes mutants
T1523 5007-5009 IN denotes of
T1524 5010-5014 NN denotes BDNF
T1525 5015-5017 CC denotes or
T1526 5018-5021 PRP$ denotes its
T1527 5022-5030 NN denotes receptor
T1528 5031-5035 NN denotes trkB
T1522 5036-5040 VBP denotes lose
T1529 5041-5044 DT denotes all
T1530 5045-5056 NN denotes innervation
T1531 5057-5059 IN denotes to
T1532 5060-5063 DT denotes the
T1534 5064-5076 JJ denotes semicircular
T1533 5077-5083 NNS denotes canals
T1535 5084-5087 CC denotes and
T1536 5088-5092 VBP denotes have
T1537 5093-5094 DT denotes a
T1539 5095-5102 VBN denotes reduced
T1538 5103-5114 NN denotes innervation
T1540 5115-5117 IN denotes to
T1541 5118-5121 DT denotes the
T1542 5122-5129 NN denotes utricle
T1543 5129-5131 , denotes ,
T1544 5131-5138 NN denotes saccule
T1545 5139-5142 CC denotes and
T1546 5143-5149 JJ denotes apical
T1547 5150-5154 NN denotes turn
T1548 5155-5157 IN denotes of
T1549 5158-5161 DT denotes the
T1550 5162-5169 NN denotes cochlea
T1551 5169-5170 . denotes .
T1552 5170-5367 sentence denotes In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip.
T1553 5171-5173 IN denotes In
T1555 5174-5182 NN denotes contrast
T1556 5182-5184 , denotes ,
T1557 5184-5188 JJ denotes null
T1558 5189-5198 NNS denotes mutations
T1559 5199-5201 IN denotes of
T1560 5202-5208 CC denotes either
T1561 5209-5211 NN denotes NT
T1562 5211-5212 HYPH denotes -
T1563 5212-5213 CD denotes 3
T1564 5214-5216 CC denotes or
T1565 5217-5220 PRP$ denotes its
T1566 5221-5229 NN denotes receptor
T1567 5230-5234 NN denotes trkC
T1554 5235-5241 VBP denotes result
T1568 5242-5244 IN denotes in
T1569 5245-5249 NN denotes loss
T1570 5250-5252 IN denotes of
T1571 5253-5259 JJ denotes spiral
T1572 5260-5267 NNS denotes neurons
T1573 5268-5270 IN denotes in
T1574 5271-5274 DT denotes the
T1576 5275-5280 JJ denotes basal
T1575 5281-5285 NN denotes turn
T1577 5286-5290 IN denotes with
T1578 5291-5300 NN denotes formation
T1579 5301-5303 IN denotes of
T1580 5304-5306 DT denotes an
T1582 5307-5312 JJ denotes inner
T1583 5313-5319 JJ denotes spiral
T1581 5320-5326 NN denotes bundle
T1584 5327-5329 IN denotes of
T1585 5330-5339 NNS denotes afferents
T1586 5340-5349 VBG denotes extending
T1587 5350-5352 IN denotes to
T1588 5353-5356 DT denotes the
T1590 5357-5362 JJ denotes basal
T1589 5363-5366 NN denotes tip
T1591 5366-5367 . denotes .
T1592 5367-5558 sentence denotes Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss.
T1593 5368-5371 PRP$ denotes Our
T1595 5372-5376 JJ denotes null
T1594 5377-5387 NN denotes hypothesis
T1597 5388-5391 IN denotes for
T1598 5392-5396 DT denotes this
T1599 5397-5402 NN denotes study
T1600 5403-5408 MD denotes would
T1596 5409-5411 VB denotes be
T1601 5412-5416 IN denotes that
T1603 5417-5422 NN denotes Brn3c
T1605 5423-5427 JJ denotes null
T1604 5428-5432 NNS denotes mice
T1602 5433-5437 VBP denotes show
T1606 5438-5444 JJ denotes severe
T1608 5445-5456 VBN denotes compromised
T1607 5457-5467 NN denotes production
T1609 5468-5470 IN denotes of
T1610 5471-5476 DT denotes these
T1611 5477-5490 NNS denotes neurotrophins
T1612 5491-5494 CC denotes and
T1613 5495-5501 MD denotes should
T1615 5502-5511 RB denotes therefore
T1614 5512-5516 VB denotes show
T1616 5517-5518 DT denotes a
T1618 5519-5529 JJ denotes comparable
T1617 5530-5537 NN denotes pattern
T1619 5538-5540 IN denotes of
T1620 5541-5546 NN denotes nerve
T1621 5547-5552 NN denotes fiber
T1622 5553-5557 NN denotes loss
T1623 5557-5558 . denotes .
R10 T197 T196 punct ", ",retention
R100 T300 T298 prep of,reduction
R101 T301 T300 pobj afferents,of
R102 T302 T301 cc or,afferents
R103 T303 T301 conj efferents,afferents
R104 T304 T305 dep that,resembles
R105 T305 T301 relcl resembles,afferents
R106 T306 T307 nmod neurotrophin,mutations
R107 T307 T305 dobj mutations,resembles
R108 T308 T307 amod null,mutations
R109 T309 T276 punct .,is
R11 T198 T196 amod incomplete,retention
R110 T311 T312 prep At,reduced
R111 T313 T314 amod postnatal,day
R112 T314 T311 pobj day,At
R113 T315 T314 nummod 7,day
R114 T316 T314 punct /,day
R115 T317 T314 nummod 8,day
R116 T318 T314 punct (,day
R117 T319 T314 appos P7,day
R118 T320 T319 punct /,P7
R119 T321 T319 nummod 8,P7
R12 T199 T196 prep of,retention
R120 T322 T312 punct ),reduced
R121 T323 T312 punct ", ",reduced
R122 T324 T312 nsubjpass innervation,reduced
R123 T325 T312 auxpass is,reduced
R124 T326 T312 advmod severely,reduced
R125 T327 T328 preconj both,qualitatively
R126 T328 T312 advmod qualitatively,reduced
R127 T329 T328 cc and,qualitatively
R128 T330 T328 conj quantitatively,qualitatively
R129 T331 T312 punct .,reduced
R13 T200 T201 det some,innervation
R130 T333 T334 nummod 1,%
R131 T334 T335 nsubj %,are
R132 T336 T334 prep of,%
R133 T337 T338 compound myosin,VIIa
R134 T338 T339 npadvmod VIIa,positive
R135 T339 T341 amod positive,cells
R136 T340 T339 punct -,positive
R137 T341 T336 pobj cells,of
R138 T342 T341 amod immature,cells
R139 T343 T341 compound hair,cells
R14 T201 T199 pobj innervation,of
R140 T344 T335 acomp present,are
R141 T345 T335 prep in,are
R142 T346 T347 det the,cochlea
R143 T347 T345 pobj cochlea,in
R144 T348 T347 amod mutant,cochlea
R145 T349 T335 punct ", ",are
R146 T350 T335 advcl concentrated,are
R147 T351 T350 prep in,concentrated
R148 T352 T353 det the,base
R149 T353 T351 pobj base,in
R15 T202 T201 amod afferent,innervation
R150 T354 T335 punct .,are
R151 T356 T357 quantmod Around,20
R152 T357 T358 nummod 20,%
R153 T358 T359 nsubj %,exist
R154 T360 T358 prep of,%
R155 T361 T362 amod immature,cells
R156 T362 T360 pobj cells,of
R157 T363 T362 compound hair,cells
R158 T364 T359 prep in,exist
R159 T365 T366 det the,epithelia
R16 T203 T204 amod inner,ear
R160 T366 T364 pobj epithelia,in
R161 T367 T366 amod mutant,epithelia
R162 T368 T366 amod vestibular,epithelia
R163 T369 T366 amod sensory,epithelia
R164 T370 T359 punct .,exist
R165 T372 T373 prep Despite,retains
R166 T374 T375 advmod more,severe
R167 T375 T376 amod severe,loss
R168 T376 T372 pobj loss,Despite
R169 T377 T376 prep of,loss
R17 T204 T201 compound ear,innervation
R170 T378 T379 compound hair,cells
R171 T379 T377 pobj cells,of
R172 T380 T381 punct (,%
R173 T381 T376 parataxis %,loss
R174 T382 T381 nummod 1,%
R175 T383 T381 prep compared,%
R176 T384 T383 prep to,compared
R177 T385 T386 nummod 20,%
R178 T386 T384 pobj %,to
R179 T387 T381 punct ),%
R18 T209 T210 nsubj Ears,develop
R180 T388 T373 punct ", ",retains
R181 T389 T390 det the,cochlea
R182 T390 T373 nsubj cochlea,retains
R183 T391 T392 amod many,neurons
R184 T392 T373 dobj neurons,retains
R185 T393 T392 amod more,neurons
R186 T394 T392 amod sensory,neurons
R187 T395 T396 punct (,%
R188 T396 T392 parataxis %,neurons
R189 T397 T396 nummod 46,%
R19 T211 T209 prep of,Ears
R190 T398 T396 prep compared,%
R191 T399 T398 prep to,compared
R192 T400 T401 nummod 15,%
R193 T401 T399 pobj %,to
R194 T402 T396 punct ),%
R195 T403 T392 prep than,neurons
R196 T404 T405 amod vestibular,epithelia
R197 T405 T403 pobj epithelia,than
R198 T406 T373 punct .,retains
R199 T408 T409 advmod Even,mice
R20 T212 T213 nmod Brn3c,mutants
R200 T409 T414 nsubj mice,have
R201 T410 T411 nummod 6,months
R202 T411 T412 npadvmod months,old
R203 T412 T409 amod old,mice
R204 T413 T409 amod mutant,mice
R205 T415 T416 det some,fibers
R206 T416 T414 dobj fibers,have
R207 T417 T416 prep to,fibers
R208 T418 T419 det all,epithelia
R209 T419 T417 pobj epithelia,to
R21 T213 T211 pobj mutants,of
R210 T420 T419 amod vestibular,epithelia
R211 T421 T419 amod sensory,epithelia
R212 T422 T416 cc and,fibers
R213 T423 T424 amod many,more
R214 T424 T416 conj more,fibers
R215 T425 T424 prep to,more
R216 T426 T427 det the,apex
R217 T427 T425 pobj apex,to
R218 T428 T427 amod cochlear,apex
R219 T429 T430 dep which,lacks
R22 T214 T213 amod null,mutants
R220 T430 T427 relcl lacks,apex
R221 T431 T432 npadvmod MyoVIIa,positive
R222 T432 T433 amod positive,cells
R223 T433 T430 dobj cells,lacks
R224 T434 T433 compound hair,cells
R225 T435 T414 punct .,have
R226 T437 T438 advmod Topologically,organized
R227 T438 T439 amod organized,projections
R228 T439 T442 nsubj projections,exist
R229 T440 T441 amod central,cochlea
R23 T215 T216 amod immature,cells
R230 T441 T439 compound cochlea,projections
R231 T443 T444 advmod at,least
R232 T444 T445 advmod least,until
R233 T445 T442 prep until,exist
R234 T446 T445 pobj P8,until
R235 T447 T442 punct ", ",exist
R236 T448 T442 advcl suggesting,exist
R237 T449 T450 mark that,required
R238 T450 T448 ccomp required,suggesting
R239 T451 T452 amod functional,cells
R24 T216 T210 dobj cells,develop
R240 T452 T450 nsubjpass cells,required
R241 T453 T452 compound hair,cells
R242 T454 T450 auxpass are,required
R243 T455 T450 neg not,required
R244 T456 T457 aux to,establish
R245 T457 T450 advcl establish,required
R246 T458 T459 amod such,projections
R247 T459 T457 dobj projections,establish
R248 T460 T442 punct .,exist
R249 T464 T465 det The,expression
R25 T217 T216 compound hair,cells
R250 T465 T467 nsubj expression,suffices
R251 T466 T465 amod limited,expression
R252 T468 T465 prep of,expression
R253 T469 T468 pobj neurotrophins,of
R254 T470 T465 prep in,expression
R255 T471 T472 det the,cochlea
R256 T472 T470 pobj cochlea,in
R257 T473 T472 prep of,cochlea
R258 T474 T475 npadvmod Brn3c,null
R259 T475 T476 amod null,mice
R26 T218 T216 punct ", ",cells
R260 T476 T473 pobj mice,of
R261 T477 T478 aux to,support
R262 T478 T467 xcomp support,suffices
R263 T479 T480 amod many,neurons
R264 T480 T478 dobj neurons,support
R265 T481 T480 amod sensory,neurons
R266 T482 T478 punct ", ",support
R267 T483 T484 advmod particularly,in
R268 T484 T478 prep in,support
R269 T485 T486 det the,cochlea
R27 T219 T216 amod identifiable,cells
R270 T486 T484 pobj cochlea,in
R271 T487 T478 punct ", ",support
R272 T488 T478 prep until,support
R273 T489 T488 pobj birth,until
R274 T490 T467 punct .,suffices
R275 T492 T493 det The,nature
R276 T493 T495 nsubj nature,remains
R277 T494 T493 amod molecular,nature
R278 T496 T493 prep of,nature
R279 T497 T498 det the,survival
R28 T220 T221 advmod only,by
R280 T498 T496 pobj survival,of
R281 T499 T500 amod long,term
R282 T500 T498 compound term,survival
R283 T501 T498 prep of,survival
R284 T502 T503 amod apical,spiral
R285 T503 T504 nmod spiral,neurons
R286 T504 T501 pobj neurons,of
R287 T505 T495 oprd unclear,remains
R288 T506 T495 punct .,remains
R289 T187 T188 npadvmod Brn3c,null
R29 T221 T219 prep by,identifiable
R3 T188 T190 amod null,mice
R30 T222 T223 amod certain,markers
R300 T820 T821 nsubj Brn3c,is
R301 T822 T823 det a,factor
R302 T823 T821 attr factor,is
R303 T824 T825 compound POU,domain
R304 T825 T823 compound domain,factor
R305 T826 T827 dep that,is
R306 T827 T823 relcl is,factor
R307 T828 T827 acomp crucial,is
R308 T829 T828 prep for,crucial
R309 T830 T831 amod inner,ear
R31 T223 T221 pobj markers,by
R310 T831 T832 nmod ear,development
R311 T832 T829 pobj development,for
R312 T833 T834 compound hair,cell
R313 T834 T832 compound cell,development
R314 T835 T821 punct .,is
R315 T837 T838 amod Targeted,mutants
R316 T838 T841 nsubj mutants,have
R317 T839 T838 amod null,mutants
R318 T840 T838 compound Brn3c,mutants
R319 T842 T843 det no,cells
R32 T224 T223 amod molecular,markers
R320 T843 T841 dobj cells,have
R321 T844 T843 amod mature,cells
R322 T845 T843 compound hair,cells
R323 T846 T847 punct [,2
R324 T847 T841 parataxis 2,have
R325 T848 T847 nummod 1,2
R326 T849 T847 punct ",",2
R327 T850 T847 punct ],2
R328 T851 T841 punct .,have
R329 T853 T854 compound Close,examination
R33 T225 T210 punct ", ",develop
R330 T854 T855 nsubj examination,revealed
R331 T856 T855 aux has,revealed
R332 T857 T858 mark that,form
R333 T858 T855 ccomp form,revealed
R334 T859 T860 det some,cells
R335 T860 T858 nsubj cells,form
R336 T861 T860 punct ',cells
R337 T862 T860 amod immature,cells
R338 T863 T860 punct ',cells
R339 T864 T860 compound hair,cells
R34 T226 T210 cc and,develop
R340 T865 T858 prep in,form
R341 T866 T867 nmod Brn3c,mutants
R342 T867 T865 pobj mutants,in
R343 T868 T867 amod null,mutants
R344 T869 T858 cc and,form
R345 T870 T858 conj express,form
R346 T871 T872 amod cellular,markers
R347 T872 T870 dobj markers,express
R348 T873 T874 amod such,as
R349 T874 T872 prep as,markers
R35 T227 T210 conj undergo,develop
R350 T875 T876 compound Myosin,VI
R351 T876 T874 pobj VI,as
R352 T877 T876 cc and,VI
R353 T878 T876 conj VIIa,VI
R354 T879 T876 punct ", ",VI
R355 T880 T876 conj calretinin,VI
R356 T881 T880 cc and,calretinin
R357 T882 T880 conj parvalbumin,calretinin
R358 T883 T884 punct [,3
R359 T884 T855 parataxis 3,revealed
R36 T228 T227 dobj apoptosis,undergo
R360 T885 T884 punct ],3
R361 T886 T855 punct .,revealed
R362 T888 T889 advmod Furthermore,undergo
R363 T890 T889 punct ", ",undergo
R364 T891 T892 det these,cells
R365 T892 T889 nsubj cells,undergo
R366 T893 T892 amod immature,cells
R367 T894 T892 compound hair,cells
R368 T895 T892 prep of,cells
R369 T896 T897 nmod Brn3c,mutants
R37 T229 T227 prep in,undergo
R370 T897 T895 pobj mutants,of
R371 T898 T897 amod null,mutants
R372 T899 T889 dobj apoptosis,undergo
R373 T900 T889 prep in,undergo
R374 T901 T900 pobj neonates,in
R375 T902 T903 punct [,3
R376 T903 T889 parataxis 3,undergo
R377 T904 T903 punct ],3
R378 T905 T889 punct .,undergo
R379 T907 T908 advcl Consistent,suggested
R38 T230 T229 pobj neonates,in
R380 T909 T907 prep with,Consistent
R381 T910 T911 det an,absence
R382 T911 T909 pobj absence,with
R383 T912 T911 amod apparent,absence
R384 T913 T911 prep of,absence
R385 T914 T915 amod mature,cells
R386 T915 T913 pobj cells,of
R387 T916 T915 compound hair,cells
R388 T917 T908 punct ", ",suggested
R389 T918 T919 amod initial,work
R39 T231 T210 punct .,develop
R390 T919 T908 nsubj work,suggested
R391 T920 T921 mark that,lost
R392 T921 T908 ccomp lost,suggested
R393 T922 T923 det all,vestibular
R394 T923 T921 nsubjpass vestibular,lost
R395 T924 T923 cc and,vestibular
R396 T925 T926 det most,spiral
R397 T926 T927 nmod spiral,cells
R398 T927 T923 conj cells,vestibular
R399 T928 T927 compound ganglion,cells
R4 T190 T192 nsubj mice,show
R40 T233 T234 det This,development
R400 T929 T921 auxpass are,lost
R401 T930 T921 prep by,lost
R402 T931 T932 amod postnatal,day
R403 T932 T930 pobj day,by
R404 T933 T932 nummod 14,day
R405 T934 T932 punct (,day
R406 T935 T932 appos P14,day
R407 T936 T921 punct ;,lost
R408 T937 T938 punct [,1
R409 T938 T921 parataxis 1,lost
R41 T234 T236 nsubj development,lead
R410 T939 T938 punct ],1
R411 T940 T921 punct ),lost
R412 T941 T908 punct .,suggested
R413 T943 T944 advmod However,reported
R414 T945 T944 punct ", ",reported
R415 T946 T947 advmod more,quantification
R416 T947 T944 nsubj quantification,reported
R417 T948 T947 amod detailed,quantification
R418 T949 T947 prep by,quantification
R419 T950 T949 pobj others,by
R42 T235 T234 amod partial,development
R420 T951 T952 punct [,3
R421 T952 T947 parataxis 3,quantification
R422 T953 T952 punct ],3
R423 T954 T955 mark that,lost
R424 T955 T944 ccomp lost,reported
R425 T956 T955 prep at,lost
R426 T957 T956 pobj P4,at
R427 T958 T959 quantmod about,77
R428 T959 T960 nummod 77,%
R429 T960 T955 nsubjpass %,lost
R43 T237 T234 prep of,development
R430 T961 T960 prep of,%
R431 T962 T963 amod vestibular,neurons
R432 T963 T961 pobj neurons,of
R433 T964 T960 cc and,%
R434 T965 T966 advmod only,29
R435 T966 T967 nummod 29,%
R436 T967 T960 conj %,%
R437 T968 T967 prep of,%
R438 T969 T970 amod spiral,neurons
R439 T970 T968 pobj neurons,of
R44 T238 T239 compound hair,cells
R440 T971 T955 auxpass are,lost
R441 T972 T944 punct .,reported
R442 T974 T975 nsubjpass It,suggested
R443 T976 T975 auxpass was,suggested
R444 T977 T978 mark that,is
R445 T978 T975 ccomp is,suggested
R446 T979 T978 expl there,is
R447 T980 T978 advmod possibly,is
R448 T981 T982 det a,loss
R449 T982 T978 attr loss,is
R45 T239 T237 pobj cells,of
R450 T983 T982 amod complete,loss
R451 T984 T978 prep in,is
R452 T985 T984 pobj adults,in
R453 T986 T987 punct [,3
R454 T987 T975 parataxis 3,suggested
R455 T988 T987 punct ],3
R456 T989 T975 punct .,suggested
R457 T991 T992 advmod Other,exists
R458 T993 T991 prep than,Other
R459 T994 T995 det these,statements
R46 T240 T236 aux could,lead
R460 T995 T993 pobj statements,than
R461 T996 T995 amod preliminary,statements
R462 T997 T992 punct ", ",exists
R463 T998 T999 det no,data
R464 T999 T992 nsubj data,exists
R465 T1000 T992 prep concerning,exists
R466 T1001 T1002 det the,pattern
R467 T1002 T1000 pobj pattern,concerning
R468 T1003 T1002 amod detailed,pattern
R469 T1004 T1002 prep of,pattern
R47 T241 T236 prep to,lead
R470 T1005 T1004 pobj loss,of
R471 T1006 T1005 prep of,loss
R472 T1007 T1006 pobj innervation,of
R473 T1008 T1005 prep in,loss
R474 T1009 T1010 npadvmod Brn3c,null
R475 T1010 T1011 amod null,mutants
R476 T1011 T1008 pobj mutants,in
R477 T1012 T992 punct .,exists
R478 T1014 T1015 det The,development
R479 T1015 T1017 nsubj development,lead
R48 T242 T243 amod enough,expression
R480 T1016 T1015 amod initial,development
R481 T1018 T1015 cc and,development
R482 T1019 T1020 amod partial,differentiation
R483 T1020 T1015 conj differentiation,development
R484 T1021 T1015 prep of,development
R485 T1022 T1023 compound hair,cells
R486 T1023 T1021 pobj cells,of
R487 T1024 T1015 prep in,development
R488 T1025 T1026 compound Brn3c,mutants
R489 T1026 T1024 pobj mutants,in
R49 T243 T241 pobj expression,to
R490 T1027 T1017 aux could,lead
R491 T1028 T1017 advmod possibly,lead
R492 T1029 T1017 prep to,lead
R493 T1030 T1031 det some,expression
R494 T1031 T1029 pobj expression,to
R495 T1032 T1031 compound neurotrophin,expression
R496 T1033 T1031 prep in,expression
R497 T1034 T1035 det these,cells
R498 T1035 T1033 pobj cells,in
R499 T1036 T1037 aux to,sustain
R5 T191 T190 amod mutant,mice
R50 T244 T243 compound neurotrophin,expression
R500 T1037 T1017 advcl sustain,lead
R501 T1038 T1039 amod sensory,neurons
R502 T1039 T1037 dobj neurons,sustain
R503 T1040 T1037 prep through,sustain
R504 T1041 T1042 amod embryonic,development
R505 T1042 T1040 pobj development,through
R506 T1043 T1040 cc and,through
R507 T1044 T1040 conj beyond,through
R508 T1045 T1017 punct .,lead
R509 T1047 T1048 nsubj Data,shown
R51 T245 T246 aux to,sustain
R510 T1049 T1047 prep on,Data
R511 T1050 T1051 amod various,mutants
R512 T1051 T1049 pobj mutants,on
R513 T1052 T1053 amod single,neurotrophin
R514 T1053 T1056 npadvmod neurotrophin,null
R515 T1054 T1052 cc and,single
R516 T1055 T1052 conj compound,single
R517 T1056 T1051 amod null,mutants
R518 T1057 T1048 aux have,shown
R519 T1058 T1059 mark that,leads
R52 T246 T243 acl sustain,expression
R520 T1059 T1048 ccomp leads,shown
R521 T1060 T1061 det the,loss
R522 T1061 T1059 nsubj loss,leads
R523 T1062 T1061 prep of,loss
R524 T1063 T1064 det a,neurotrophin
R525 T1064 T1062 pobj neurotrophin,of
R526 T1065 T1064 amod specific,neurotrophin
R527 T1066 T1059 prep to,leads
R528 T1067 T1068 advmod topologically,restricted
R529 T1068 T1069 amod restricted,loss
R53 T247 T248 amod sensory,neurons
R530 T1069 T1066 pobj loss,to
R531 T1070 T1069 prep of,loss
R532 T1071 T1072 amod sensory,neurons
R533 T1072 T1070 pobj neurons,of
R534 T1073 T1069 prep in,loss
R535 T1074 T1075 det the,ear
R536 T1075 T1073 pobj ear,in
R537 T1076 T1075 amod embryonic,ear
R538 T1077 T1078 punct [,5
R539 T1078 T1048 parataxis 5,shown
R54 T248 T246 dobj neurons,sustain
R540 T1079 T1078 nummod 4,5
R541 T1080 T1078 punct ",",5
R542 T1081 T1078 punct ],5
R543 T1082 T1048 punct .,shown
R544 T1084 T1085 amod Such,loss
R545 T1085 T1087 nsubj loss,indicate
R546 T1086 T1085 amod selective,loss
R547 T1088 T1085 prep in,loss
R548 T1089 T1090 nmod Brn3c,mutants
R549 T1090 T1088 pobj mutants,in
R55 T249 T246 prep through,sustain
R550 T1091 T1090 amod null,mutants
R551 T1092 T1087 aux would,indicate
R552 T1093 T1087 advmod therefore,indicate
R553 T1094 T1087 dobj reduction,indicate
R554 T1095 T1094 prep of,reduction
R555 T1096 T1097 det a,neurotrophin
R556 T1097 T1095 pobj neurotrophin,of
R557 T1098 T1097 amod specific,neurotrophin
R558 T1099 T1094 prep in,reduction
R559 T1100 T1101 amod immature,cells
R56 T250 T251 amod embryonic,development
R560 T1101 T1099 pobj cells,in
R561 T1102 T1101 compound hair,cells
R562 T1103 T1087 punct .,indicate
R563 T1105 T1106 advmod Moreover,shows
R564 T1107 T1106 punct ", ",shows
R565 T1108 T1109 amod recent,work
R566 T1109 T1106 nsubj work,shows
R567 T1110 T1111 mark that,expressed
R568 T1111 T1106 ccomp expressed,shows
R569 T1112 T1111 prep in,expressed
R57 T251 T249 pobj development,through
R570 T1113 T1112 pobj embryos,in
R571 T1114 T1111 nsubjpass NT,expressed
R572 T1115 T1114 punct -,NT
R573 T1116 T1114 nummod 3,NT
R574 T1117 T1111 auxpass is,expressed
R575 T1118 T1111 advmod primarily,expressed
R576 T1119 T1111 prep in,expressed
R577 T1120 T1121 amod supporting,cells
R578 T1121 T1119 pobj cells,in
R579 T1122 T1111 punct ", ",expressed
R58 T252 T236 punct .,lead
R580 T1123 T1111 advcl moving,expressed
R581 T1124 T1125 advmod only,around
R582 T1125 T1123 prep around,moving
R583 T1126 T1125 pobj birth,around
R584 T1127 T1123 prep into,moving
R585 T1128 T1129 compound hair,cells
R586 T1129 T1127 pobj cells,into
R587 T1130 T1131 punct [,7
R588 T1131 T1106 parataxis 7,shows
R589 T1132 T1131 nummod 6,7
R59 T254 T255 nsubj We,investigated
R590 T1133 T1131 punct ",",7
R591 T1134 T1131 punct ],7
R592 T1135 T1106 punct .,shows
R593 T1137 T1138 prep In,suggests
R594 T1139 T1137 pobj fact,In
R595 T1140 T1138 punct ", ",suggests
R596 T1141 T1142 det the,loss
R597 T1142 T1138 nsubj loss,suggests
R598 T1143 T1142 amod selective,loss
R599 T1144 T1142 prep of,loss
R6 T193 T194 amod long,term
R60 T256 T255 aux have,investigated
R600 T1145 T1144 pobj vestibular,of
R601 T1146 T1145 prep as,vestibular
R602 T1147 T1146 prep compared,as
R603 T1148 T1147 prep to,compared
R604 T1149 T1148 pobj cochlear,to
R605 T1150 T1151 amod sensory,neurons
R606 T1151 T1145 appos neurons,vestibular
R607 T1152 T1153 punct (,%
R608 T1153 T1145 parataxis %,vestibular
R609 T1154 T1153 nummod 77,%
R61 T257 T255 advmod therefore,investigated
R610 T1155 T1153 cc versus,%
R611 T1156 T1157 nummod 29,%
R612 T1157 T1153 conj %,%
R613 T1158 T1153 punct ;,%
R614 T1159 T1160 punct [,3
R615 T1160 T1153 parataxis 3,%
R616 T1161 T1160 punct ],3
R617 T1162 T1153 punct ),%
R618 T1163 T1164 mark that,be
R619 T1164 T1138 ccomp be,suggests
R62 T258 T255 prep in,investigated
R620 T1165 T1166 nmod NT,expression
R621 T1166 T1164 nsubj expression,be
R622 T1167 T1165 punct -,NT
R623 T1168 T1165 nummod 3,NT
R624 T1169 T1164 aux may,be
R625 T1170 T1171 advmod less,downregulated
R626 T1171 T1164 acomp downregulated,be
R627 T1172 T1164 prep in,be
R628 T1173 T1174 nmod Brn3c,mutants
R629 T1174 T1172 pobj mutants,in
R63 T259 T260 det these,mutants
R630 T1175 T1174 amod null,mutants
R631 T1176 T1164 prep than,be
R632 T1177 T1176 pobj BDNF,than
R633 T1178 T1179 punct [,9
R634 T1179 T1164 parataxis 9,be
R635 T1180 T1179 nummod 6,9
R636 T1181 T1179 punct ",",9
R637 T1182 T1179 nummod 8,9
R638 T1183 T1179 punct ",",9
R639 T1184 T1179 punct ],9
R64 T260 T258 pobj mutants,in
R640 T1185 T1164 punct ", ",be
R641 T1186 T1164 prep provided,be
R642 T1187 T1188 mark that,takes
R643 T1188 T1186 pcomp takes,provided
R644 T1189 T1190 advmod at,least
R645 T1190 T1191 advmod least,differentiation
R646 T1191 T1188 nsubj differentiation,takes
R647 T1192 T1191 det some,differentiation
R648 T1193 T1191 prep of,differentiation
R649 T1194 T1195 amod supporting,cells
R65 T261 T262 det the,patterns
R650 T1195 T1193 pobj cells,of
R651 T1196 T1188 dobj place,takes
R652 T1197 T1138 punct .,suggests
R653 T1199 T1200 prep In,downregulated
R654 T1201 T1202 det the,ear
R655 T1202 T1199 pobj ear,In
R656 T1203 T1204 punct [,4
R657 T1204 T1199 parataxis 4,In
R658 T1205 T1204 punct ],4
R659 T1206 T1207 advmod as,as
R66 T262 T255 dobj patterns,investigated
R660 T1207 T1199 cc as,In
R661 T1208 T1207 advmod well,as
R662 T1209 T1210 advmod elsewhere,10
R663 T1210 T1199 conj 10,In
R664 T1211 T1210 punct [,10
R665 T1212 T1210 punct ],10
R666 T1213 T1200 nsubjpass neurotrophins,downregulated
R667 T1214 T1200 auxpass are,downregulated
R668 T1215 T1200 advmod progressively,downregulated
R669 T1216 T1200 prep in,downregulated
R67 T263 T262 prep of,patterns
R670 T1217 T1218 amod postnatal,mammals
R671 T1218 T1216 pobj mammals,in
R672 T1219 T1200 cc and,downregulated
R673 T1220 T1221 advmod possibly,replaced
R674 T1221 T1200 conj replaced,downregulated
R675 T1222 T1221 agent by,replaced
R676 T1223 T1224 amod other,factors
R677 T1224 T1222 pobj factors,by
R678 T1225 T1226 punct [,11
R679 T1226 T1221 parataxis 11,replaced
R68 T264 T263 pobj innervation,of
R680 T1227 T1226 punct ],11
R681 T1228 T1200 punct .,downregulated
R682 T1230 T1231 nsubj We,investigated
R683 T1232 T1231 aux have,investigated
R684 T1233 T1231 prep in,investigated
R685 T1234 T1233 pobj detail,in
R686 T1235 T1236 det the,pattern
R687 T1236 T1231 dobj pattern,investigated
R688 T1237 T1236 prep of,pattern
R689 T1238 T1237 pobj innervation,of
R69 T265 T263 cc and,of
R690 T1239 T1236 prep in,pattern
R691 T1240 T1241 det the,mutants
R692 T1241 T1239 pobj mutants,in
R693 T1242 T1241 compound Brn3c,mutants
R694 T1243 T1236 punct ", ",pattern
R695 T1244 T1245 advmod as,as
R696 T1245 T1236 cc as,pattern
R697 T1246 T1245 advmod well,as
R698 T1247 T1248 det the,expression
R699 T1248 T1236 conj expression,pattern
R7 T194 T196 nmod term,retention
R70 T266 T263 conj of,of
R700 T1249 T1248 prep of,expression
R701 T1250 T1249 pobj NT,of
R702 T1251 T1250 punct -,NT
R703 T1252 T1250 nummod 3,NT
R704 T1253 T1250 cc and,NT
R705 T1254 T1250 conj BDNF,NT
R706 T1255 T1231 punct .,investigated
R707 T1257 T1258 nsubj We,want
R708 T1259 T1260 aux to,evaluate
R709 T1260 T1258 xcomp evaluate,want
R71 T267 T266 pobj expression,of
R710 T1261 T1262 det a,correlation
R711 T1262 T1260 dobj correlation,evaluate
R712 T1263 T1262 amod possible,correlation
R713 T1264 T1262 prep between,correlation
R714 T1265 T1266 det the,topology
R715 T1266 T1264 pobj topology,between
R716 T1267 T1266 prep of,topology
R717 T1268 T1269 amod sensory,neuron
R718 T1269 T1270 compound neuron,loss
R719 T1270 T1267 pobj loss,of
R72 T268 T266 prep of,of
R720 T1271 T1266 cc and,topology
R721 T1272 T1266 conj absence,topology
R722 T1273 T1272 prep of,absence
R723 T1274 T1275 det a,neurotrophin
R724 T1275 T1273 pobj neurotrophin,of
R725 T1276 T1275 amod specific,neurotrophin
R726 T1277 T1275 cc or,neurotrophin
R727 T1278 T1279 amod topological,loss
R728 T1279 T1275 conj loss,neurotrophin
R729 T1280 T1279 prep of,loss
R73 T269 T270 amod known,neurotrophins
R730 T1281 T1282 compound hair,cells
R731 T1282 T1280 pobj cells,of
R732 T1283 T1262 prep at,correlation
R733 T1284 T1283 pobj birth,at
R734 T1285 T1283 cc and,at
R735 T1286 T1283 conj in,at
R736 T1287 T1288 amod older,animals
R737 T1288 T1286 pobj animals,in
R738 T1289 T1258 punct .,want
R739 T1291 T1292 det This,information
R74 T270 T268 pobj neurotrophins,of
R740 T1292 T1293 nsubj information,be
R741 T1294 T1293 aux could,be
R742 T1295 T1293 acomp important,be
R743 T1296 T1295 prep for,important
R744 T1297 T1298 det an,evaluation
R745 T1298 T1296 pobj evaluation,for
R746 T1299 T1298 nmod in,evaluation
R747 T1300 T1299 punct -,in
R748 T1301 T1299 pobj depth,in
R749 T1302 T1298 prep of,evaluation
R75 T271 T255 punct .,investigated
R750 T1303 T1304 det the,deafness
R751 T1304 T1302 pobj deafness,of
R752 T1305 T1304 amod human,deafness
R753 T1306 T1304 acl related,deafness
R754 T1307 T1306 prep to,related
R755 T1308 T1309 det the,gene
R756 T1309 T1307 pobj gene,to
R757 T1310 T1309 compound Pou4f3,gene
R758 T1311 T1309 punct ", ",gene
R759 T1312 T1309 appos DFNA15,gene
R76 T275 T276 prep At,is
R760 T1313 T1314 punct [,12
R761 T1314 T1293 parataxis 12,be
R762 T1315 T1314 punct ],12
R763 T1316 T1293 punct .,be
R764 T1318 T1319 nsubj We,report
R765 T1320 T1319 advmod here,report
R766 T1321 T1322 amod long,term
R767 T1322 T1323 compound term,retention
R768 T1323 T1319 dobj retention,report
R769 T1324 T1323 prep of,retention
R77 T277 T275 pobj birth,At
R770 T1325 T1326 amod cochlear,neurons
R771 T1326 T1324 pobj neurons,of
R772 T1327 T1326 amod sensory,neurons
R773 T1328 T1323 prep for,retention
R774 T1329 T1330 advmod at,6
R775 T1330 T1332 nummod 6,months
R776 T1331 T1330 advmod least,6
R777 T1332 T1328 pobj months,for
R778 T1333 T1323 punct ", ",retention
R779 T1334 T1335 prep in,in
R78 T278 T276 expl there,is
R780 T1335 T1323 prep in,retention
R781 T1336 T1334 amod particular,in
R782 T1337 T1338 det the,apex
R783 T1338 T1335 pobj apex,in
R784 T1339 T1338 amod cochlear,apex
R785 T1340 T1323 punct ", ",retention
R786 T1341 T1323 prep in,retention
R787 T1342 T1343 npadvmod Brn3c,null
R788 T1343 T1344 amod null,mice
R789 T1344 T1341 pobj mice,in
R79 T279 T280 det a,expression
R790 T1345 T1344 amod mutant,mice
R791 T1346 T1319 punct .,report
R792 T1348 T1349 det This,retention
R793 T1349 T1350 nsubj retention,is
R794 T1351 T1349 prep of,retention
R795 T1352 T1351 pobj afferents,of
R796 T1353 T1352 cc and,afferents
R797 T1354 T1352 conj efferents,afferents
R798 T1355 T1350 acomp unrelated,is
R799 T1356 T1355 prep to,unrelated
R8 T195 T194 punct -,term
R80 T280 T276 attr expression,is
R800 T1357 T1358 compound hair,cell
R801 T1358 T1359 compound cell,differentiation
R802 T1359 T1356 pobj differentiation,to
R803 T1360 T1361 mark as,detected
R804 T1361 T1350 advcl detected,is
R805 T1362 T1363 neg not,cells
R806 T1363 T1361 nsubjpass cells,detected
R807 T1364 T1363 advmod even,cells
R808 T1365 T1363 amod immature,cells
R809 T1366 T1363 compound hair,cells
R81 T281 T280 amod limited,expression
R810 T1367 T1361 aux can,detected
R811 T1368 T1361 auxpass be,detected
R812 T1369 T1361 prep at,detected
R813 T1370 T1371 amod early,stages
R814 T1371 T1369 pobj stages,at
R815 T1372 T1371 amod postnatal,stages
R816 T1373 T1361 prep with,detected
R817 T1374 T1375 compound MyoVII,immunocytochemistry
R818 T1375 T1373 pobj immunocytochemistry,with
R819 T1376 T1361 prep in,detected
R82 T282 T280 prep of,expression
R820 T1377 T1378 det this,part
R821 T1378 T1376 pobj part,in
R822 T1379 T1378 prep of,part
R823 T1380 T1381 det the,cochlea
R824 T1381 T1379 pobj cochlea,of
R825 T1382 T1350 punct .,is
R826 T1384 T1385 det This,retention
R827 T1385 T1386 nsubj retention,is
R828 T1387 T1385 prep of,retention
R829 T1388 T1389 amod apical,neurons
R83 T283 T282 pobj BDNF,of
R830 T1389 T1387 pobj neurons,of
R831 T1390 T1389 amod spiral,neurons
R832 T1391 T1386 advmod also,is
R833 T1392 T1393 advmod largely,unrelated
R834 T1393 T1386 acomp unrelated,is
R835 T1394 T1393 prep to,unrelated
R836 T1395 T1394 pobj neurotrophins,to
R837 T1396 T1397 dep which,known
R838 T1397 T1395 relcl known,neurotrophins
R839 T1398 T1397 auxpass are,known
R84 T284 T283 cc and,BDNF
R840 T1399 T1400 aux to,reduced
R841 T1400 T1397 xcomp reduced,known
R842 T1401 T1400 auxpass be,reduced
R843 T1402 T1400 prep in,reduced
R844 T1403 T1404 poss their,expression
R845 T1404 T1402 pobj expression,in
R846 T1405 T1397 prep in,known
R847 T1406 T1407 amod neonatal,rodents
R848 T1407 T1405 pobj rodents,in
R849 T1408 T1409 punct [,4
R85 T285 T283 conj NT,BDNF
R850 T1409 T1386 parataxis 4,is
R851 T1410 T1409 punct ],4
R852 T1411 T1386 punct .,is
R854 T1476 T1477 aux To,appreciate
R855 T1477 T1478 advcl appreciate,want
R856 T1479 T1480 det the,effects
R857 T1480 T1477 dobj effects,appreciate
R858 T1481 T1480 prep of,effects
R859 T1482 T1483 det the,mutation
R86 T286 T285 punct -,NT
R860 T1483 T1481 pobj mutation,of
R861 T1484 T1483 nmod Brn3c,mutation
R862 T1485 T1483 amod null,mutation
R863 T1486 T1480 prep on,effects
R864 T1487 T1488 det the,pattern
R865 T1488 T1486 pobj pattern,on
R866 T1489 T1488 prep of,pattern
R867 T1490 T1491 det the,innervation
R868 T1491 T1489 pobj innervation,of
R869 T1492 T1493 amod inner,ear
R87 T287 T285 nummod 3,NT
R870 T1493 T1491 compound ear,innervation
R871 T1494 T1478 punct ", ",want
R872 T1495 T1478 nsubj we,want
R873 T1496 T1478 advmod first,want
R874 T1497 T1498 aux to,present
R875 T1498 T1478 xcomp present,want
R876 T1499 T1500 det the,effects
R877 T1500 T1498 dobj effects,present
R878 T1501 T1500 prep of,effects
R879 T1502 T1503 nmod BDNF,mutations
R88 T288 T276 prep in,is
R880 T1503 T1501 pobj mutations,of
R881 T1504 T1502 cc and,BDNF
R882 T1505 T1502 conj NT,BDNF
R883 T1506 T1505 punct -,NT
R884 T1507 T1505 nummod 3,NT
R885 T1508 T1503 amod null,mutations
R886 T1509 T1503 prep at,mutations
R887 T1510 T1509 pobj birth,at
R888 T1511 T1512 punct [,14
R889 T1512 T1478 parataxis 14,want
R89 T289 T290 det the,epithelia
R890 T1513 T1512 nummod 6,14
R891 T1514 T1512 punct ",",14
R892 T1515 T1512 nummod 13,14
R893 T1516 T1512 punct ",",14
R894 T1517 T1512 punct ],14
R895 T1518 T1478 punct .,want
R896 T1520 T1521 amod Null,mutants
R897 T1521 T1522 nsubj mutants,lose
R898 T1523 T1521 prep of,mutants
R899 T1524 T1523 pobj BDNF,of
R9 T196 T192 dobj retention,show
R90 T290 T288 pobj epithelia,in
R900 T1525 T1524 cc or,BDNF
R901 T1526 T1527 poss its,receptor
R902 T1527 T1524 conj receptor,BDNF
R903 T1528 T1527 appos trkB,receptor
R904 T1529 T1530 det all,innervation
R905 T1530 T1522 dobj innervation,lose
R906 T1531 T1530 prep to,innervation
R907 T1532 T1533 det the,canals
R908 T1533 T1531 pobj canals,to
R909 T1534 T1533 amod semicircular,canals
R91 T291 T290 amod mutant,epithelia
R910 T1535 T1522 cc and,lose
R911 T1536 T1522 conj have,lose
R912 T1537 T1538 det a,innervation
R913 T1538 T1536 dobj innervation,have
R914 T1539 T1538 amod reduced,innervation
R915 T1540 T1538 prep to,innervation
R916 T1541 T1542 det the,utricle
R917 T1542 T1540 pobj utricle,to
R918 T1543 T1542 punct ", ",utricle
R919 T1544 T1542 conj saccule,utricle
R92 T292 T290 amod sensory,epithelia
R920 T1545 T1544 cc and,saccule
R921 T1546 T1547 amod apical,turn
R922 T1547 T1544 conj turn,saccule
R923 T1548 T1547 prep of,turn
R924 T1549 T1550 det the,cochlea
R925 T1550 T1548 pobj cochlea,of
R926 T1551 T1522 punct .,lose
R927 T1553 T1554 prep In,result
R928 T1555 T1553 pobj contrast,In
R929 T1556 T1554 punct ", ",result
R93 T293 T276 cc and,is
R930 T1557 T1558 amod null,mutations
R931 T1558 T1554 nsubj mutations,result
R932 T1559 T1558 prep of,mutations
R933 T1560 T1561 preconj either,NT
R934 T1561 T1559 pobj NT,of
R935 T1562 T1561 punct -,NT
R936 T1563 T1561 nummod 3,NT
R937 T1564 T1561 cc or,NT
R938 T1565 T1566 poss its,receptor
R939 T1566 T1561 conj receptor,NT
R94 T294 T295 compound DiI,tracing
R940 T1567 T1566 appos trkC,receptor
R941 T1568 T1554 prep in,result
R942 T1569 T1568 pobj loss,in
R943 T1570 T1569 prep of,loss
R944 T1571 T1572 amod spiral,neurons
R945 T1572 T1570 pobj neurons,of
R946 T1573 T1569 prep in,loss
R947 T1574 T1575 det the,turn
R948 T1575 T1573 pobj turn,in
R949 T1576 T1575 amod basal,turn
R95 T295 T296 nsubj tracing,shows
R950 T1577 T1569 prep with,loss
R951 T1578 T1577 pobj formation,with
R952 T1579 T1578 prep of,formation
R953 T1580 T1581 det an,bundle
R954 T1581 T1579 pobj bundle,of
R955 T1582 T1583 amod inner,spiral
R956 T1583 T1581 nmod spiral,bundle
R957 T1584 T1581 prep of,bundle
R958 T1585 T1584 pobj afferents,of
R959 T1586 T1581 acl extending,bundle
R96 T296 T276 conj shows,is
R960 T1587 T1586 prep to,extending
R961 T1588 T1589 det the,tip
R962 T1589 T1587 pobj tip,to
R963 T1590 T1589 amod basal,tip
R964 T1591 T1554 punct .,result
R965 T1593 T1594 poss Our,hypothesis
R966 T1594 T1596 nsubj hypothesis,be
R967 T1595 T1594 amod null,hypothesis
R968 T1597 T1594 prep for,hypothesis
R969 T1598 T1599 det this,study
R97 T297 T298 det no,reduction
R970 T1599 T1597 pobj study,for
R971 T1600 T1596 aux would,be
R972 T1601 T1602 mark that,show
R973 T1602 T1596 ccomp show,be
R974 T1603 T1604 nmod Brn3c,mice
R975 T1604 T1602 nsubj mice,show
R976 T1605 T1604 amod null,mice
R977 T1606 T1607 amod severe,production
R978 T1607 T1602 dobj production,show
R979 T1608 T1607 amod compromised,production
R98 T298 T296 dobj reduction,shows
R980 T1609 T1607 prep of,production
R981 T1610 T1611 det these,neurotrophins
R982 T1611 T1609 pobj neurotrophins,of
R983 T1612 T1602 cc and,show
R984 T1613 T1614 aux should,show
R985 T1614 T1602 conj show,show
R986 T1615 T1614 advmod therefore,show
R987 T1616 T1617 det a,pattern
R988 T1617 T1614 dobj pattern,show
R989 T1618 T1617 amod comparable,pattern
R99 T299 T298 amod specific,reduction
R990 T1619 T1617 prep of,pattern
R991 T1620 T1621 compound nerve,fiber
R992 T1621 T1622 compound fiber,loss
R993 T1622 T1619 pobj loss,of
R994 T1623 T1596 punct .,be
R999 T1846 T1847 npadvmod Brn3c,null