PMC:149366 JSON TXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id	Subject	Object	Predicate	Lexical cue
T1846	0-5	NN	denotes	Brn3c
T2767	0-5	NN	denotes	Brn3c
T187	0-5	NN	denotes	Brn3c
T189	0-98	sentence	denotes	Brn3c null mutant mice show long-term, incomplete retention of some afferent inner ear innervation
T188	6-10	JJ	denotes	null
T1847	6-10	JJ	denotes	null
T2769	6-10	JJ	denotes	null
T191	11-17	JJ	denotes	mutant
T1848	11-5578	NNS	denotes	mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants
T2768	11-9929	NNS	denotes	mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants at birth (P0) Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13,15]. The reduction in apparent size of the vestibular ganglia is in agreement with quantitative data published previously [3,13]. These data suggest a loss of 80–85% of vestibular sensory neurons in BDNF and trkB null mutants [13] and of 77% of vestibular sensory neurons in P4 Brn3c null mutants [3]. Thus, the size reduction in the vestibular sensory ganglion could be compatible with a loss of BDNF production in the immature hair cells. Figure 1 Size variations of vestibular ganglia in control and mutant littermates labeled with DiI. In newborn animals, the vestibular ganglion shows a dramatic reduction in Brn3c null mutants (b) compared to control littermates (a). Abbreviations for this and other figures: AC, anterior crista; ggl, ganglion; c, spiral capillary; Genic. ggl., geniculate ganglion; GER, greater epithelial ridge; HC, horizontal crista; HaC, vestibular hair cell; IHC, inner hair cell; iHC, immature hair cell; IGSB, intraganglionic spiral bundle; OHC, outer hair cell; PC, posterior crista; S, saccule; SG, spiral ganglion; TM, tectorial membrane; U, utricle; VCN, ventral cochlear nucleus; VG, vestibular ganglion. Bar indicates 1000 μm. However, the Brn3c null mutants show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia. There is no specific loss of all afferent and efferent innervation to the canal crista (Fig. 2a), a hallmark of both BDNF and trkB null mutations [13,15]. In fact, the reduction of fibers seems to be rather uniform throughout a given sensory epithelium with the crista innervation being qualitatively no more reduced than the innervation of the utricle and saccule. No loss in specific areas, comparable to that in BDNF null mutant mice, is apparent in the saccule or utricle of Brn3c null mice. Similar patterns of innervation are obtained using acteylated tubulin immunocytochemistry (Fig. 2b). Figure 2 Innervation of Brn3c null and control ears are shown for newborn mice. There is no specific loss of fibers to any vestibular endorgan, as visualized by DiI labeling (a) or acetylated tubulin immunoreactivity (b). No major differences in pattern of projection through radial fibers are found in the cochlea of Brn3c null mutants (d,f) as compared to control littermates (c). Note, however, the lack of orderly fiber outgrowth to the outer hair cells (c, d). Efferent fibers to the ear show a well developed intraganglionic spiral bundle (IGSB) with no detectable differences compared to controls (e). Bar indicates 100 μm. Consistent with the finding of Xiang et al. [3] of only a 29% loss of spiral sensory neurons at P4, our data show little difference in the pattern of innervation of the cochlea in P0 Brn3c null mutants (Fig. 2c,2d). No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [6,9,14]. Likewise, the innervation of the apex (Fig. 2f) shows no detectable abnormality in overall pattern of innervation compared to control animals (data not shown), an indication that BDNF could be expressed in the apex [6]. In addition, the pattern of efferent innervation shows no deviation from normal either (Fig. 2e), whereas they show the same pattern of loss as afferent fibers in neurotrophin null mutants [16]. These data suggest that the spiral sensory neurons develop qualitatively normal at least until P0 and therefore allow normal pathfinding of efferents. Most interestingly, there is no increase in radial fiber spacing in the apex, a specific problem of BDNF null mutants [6,13]. However, there is one qualitative difference not recognized in any single neurotrophin null mutant. Afferents reach all three rows of outer hair cells in the basal turn of control wildtype littermates (Fig. 2c), but both afferent and efferent outgrowth is disorganized to outer hair cells in Brn3c null mutants (Fig. 2d) and does not show any clear organization into three distinct longitudinal fiber bundles paralleling the three rows in the outer hair cell region. These data suggest that fiber organization in the outer hair cell region is partly disrupted in Brn3c null mutant. Brn3c null mutants
T190	18-22	NNS	denotes	mice
T192	23-27	VBP	denotes	show
T193	28-32	JJ	denotes	long
T195	32-33	HYPH	denotes	-
T194	33-37	NN	denotes	term
T197	37-39	,	denotes	,
T198	39-49	JJ	denotes	incomplete
T196	50-59	NN	denotes	retention
T199	60-62	IN	denotes	of
T200	63-67	DT	denotes	some
T202	68-76	JJ	denotes	afferent
T203	77-82	JJ	denotes	inner
T204	83-86	NN	denotes	ear
T201	87-98	NN	denotes	innervation
T205	98-99	sentence	denotes
T206	109-119	sentence	denotes	Background
T207	109-119	NN	denotes	Background
T208	119-258	sentence	denotes	Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates.
T209	120-124	NNS	denotes	Ears
T211	125-127	IN	denotes	of
T212	128-133	NN	denotes	Brn3c
T214	134-138	JJ	denotes	null
T213	139-146	NNS	denotes	mutants
T210	147-154	VBP	denotes	develop
T215	155-163	JJ	denotes	immature
T217	164-168	NN	denotes	hair
T216	169-174	NNS	denotes	cells
T218	174-176	,	denotes	,
T219	176-188	JJ	denotes	identifiable
T220	189-193	RB	denotes	only
T221	194-196	IN	denotes	by
T222	197-204	JJ	denotes	certain
T224	205-214	JJ	denotes	molecular
T223	215-222	NNS	denotes	markers
T225	222-224	,	denotes	,
T226	224-227	CC	denotes	and
T227	228-235	VBP	denotes	undergo
T228	236-245	NN	denotes	apoptosis
T229	246-248	IN	denotes	in
T230	249-257	NNS	denotes	neonates
T231	257-258	.	denotes	.
T232	258-400	sentence	denotes	This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development.
T233	259-263	DT	denotes	This
T235	264-271	JJ	denotes	partial
T234	272-283	NN	denotes	development
T237	284-286	IN	denotes	of
T238	287-291	NN	denotes	hair
T239	292-297	NNS	denotes	cells
T240	298-303	MD	denotes	could
T236	304-308	VB	denotes	lead
T241	309-311	IN	denotes	to
T242	312-318	JJ	denotes	enough
T244	319-331	NN	denotes	neurotrophin
T243	332-342	NN	denotes	expression
T245	343-345	TO	denotes	to
T246	346-353	VB	denotes	sustain
T247	354-361	JJ	denotes	sensory
T248	362-369	NNS	denotes	neurons
T249	370-377	IN	denotes	through
T250	378-387	JJ	denotes	embryonic
T251	388-399	NN	denotes	development
T252	399-400	.	denotes	.
T253	400-518	sentence	denotes	We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins.
T254	401-403	PRP	denotes	We
T256	404-408	VBP	denotes	have
T257	409-418	RB	denotes	therefore
T255	419-431	VBN	denotes	investigated
T258	432-434	IN	denotes	in
T259	435-440	DT	denotes	these
T260	441-448	NNS	denotes	mutants
T261	449-452	DT	denotes	the
T262	453-461	NNS	denotes	patterns
T263	462-464	IN	denotes	of
T264	465-476	NN	denotes	innervation
T265	477-480	CC	denotes	and
T266	481-483	IN	denotes	of
T267	484-494	NN	denotes	expression
T268	495-497	IN	denotes	of
T269	498-503	JJ	denotes	known
T270	504-517	NNS	denotes	neurotrophins
T271	517-518	.	denotes	.
T272	518-527	sentence	denotes	Results
T273	520-527	NNS	denotes	Results
T274	527-729	sentence	denotes	At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations.
T275	528-530	IN	denotes	At
T277	531-536	NN	denotes	birth
T278	537-542	EX	denotes	there
T276	543-545	VBZ	denotes	is
T279	546-547	DT	denotes	a
T281	548-555	VBN	denotes	limited
T280	556-566	NN	denotes	expression
T282	567-569	IN	denotes	of
T283	570-574	NN	denotes	BDNF
T284	575-578	CC	denotes	and
T285	579-581	NN	denotes	NT
T286	581-582	HYPH	denotes	-
T287	582-583	CD	denotes	3
T288	584-586	IN	denotes	in
T289	587-590	DT	denotes	the
T291	591-597	JJ	denotes	mutant
T292	598-605	JJ	denotes	sensory
T290	606-615	NNS	denotes	epithelia
T293	616-619	CC	denotes	and
T294	620-623	NN	denotes	DiI
T295	624-631	NN	denotes	tracing
T296	632-637	VBZ	denotes	shows
T297	638-640	DT	denotes	no
T299	641-649	JJ	denotes	specific
T298	650-659	NN	denotes	reduction
T300	660-662	IN	denotes	of
T301	663-672	NNS	denotes	afferents
T302	673-675	CC	denotes	or
T303	676-685	NNS	denotes	efferents
T304	686-690	WDT	denotes	that
T305	691-700	VBZ	denotes	resembles
T306	701-713	NN	denotes	neurotrophin
T308	714-718	JJ	denotes	null
T307	719-728	NNS	denotes	mutations
T309	728-729	.	denotes	.
T310	729-829	sentence	denotes	At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively.
T311	730-732	IN	denotes	At
T313	733-742	JJ	denotes	postnatal
T314	743-746	NN	denotes	day
T315	747-748	CD	denotes	7
T316	748-749	HYPH	denotes	/
T317	749-750	CD	denotes	8
T318	751-752	-LRB-	denotes	(
T319	752-754	NN	denotes	P7
T320	754-755	HYPH	denotes	/
T321	755-756	CD	denotes	8
T322	756-757	-RRB-	denotes	)
T323	757-759	,	denotes	,
T324	759-770	NN	denotes	innervation
T325	771-773	VBZ	denotes	is
T326	774-782	RB	denotes	severely
T312	783-790	VBN	denotes	reduced
T327	791-795	CC	denotes	both
T328	796-809	RB	denotes	qualitatively
T329	810-813	CC	denotes	and
T330	814-828	RB	denotes	quantitatively
T331	828-829	.	denotes	.
T332	829-937	sentence	denotes	1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base.
T333	830-831	CD	denotes	1
T334	831-832	NN	denotes	%
T336	833-835	IN	denotes	of
T337	836-842	NN	denotes	myosin
T338	843-847	NN	denotes	VIIa
T340	847-848	HYPH	denotes	-
T339	848-856	JJ	denotes	positive
T342	857-865	JJ	denotes	immature
T343	866-870	NN	denotes	hair
T341	871-876	NNS	denotes	cells
T335	877-880	VBP	denotes	are
T344	881-888	JJ	denotes	present
T345	889-891	IN	denotes	in
T346	892-895	DT	denotes	the
T348	896-902	JJ	denotes	mutant
T347	903-910	NN	denotes	cochlea
T349	910-912	,	denotes	,
T350	912-924	VBD	denotes	concentrated
T351	925-927	IN	denotes	in
T352	928-931	DT	denotes	the
T353	932-936	NN	denotes	base
T354	936-937	.	denotes	.
T355	937-1021	sentence	denotes	Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia.
T356	938-944	IN	denotes	Around
T357	945-947	CD	denotes	20
T358	947-948	NN	denotes	%
T360	949-951	IN	denotes	of
T361	952-960	JJ	denotes	immature
T363	961-965	NN	denotes	hair
T362	966-971	NNS	denotes	cells
T359	972-977	VBP	denotes	exist
T364	978-980	IN	denotes	in
T365	981-984	DT	denotes	the
T367	985-991	JJ	denotes	mutant
T368	992-1002	JJ	denotes	vestibular
T369	1003-1010	JJ	denotes	sensory
T366	1011-1020	NNS	denotes	epithelia
T370	1020-1021	.	denotes	.
T371	1021-1177	sentence	denotes	Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia.
T372	1022-1029	IN	denotes	Despite
T374	1030-1034	RBR	denotes	more
T375	1035-1041	JJ	denotes	severe
T376	1042-1046	NN	denotes	loss
T377	1047-1049	IN	denotes	of
T378	1050-1054	NN	denotes	hair
T379	1055-1060	NNS	denotes	cells
T380	1061-1062	-LRB-	denotes	(
T382	1062-1063	CD	denotes	1
T381	1063-1064	NN	denotes	%
T383	1065-1073	VBN	denotes	compared
T384	1074-1076	IN	denotes	to
T385	1077-1079	CD	denotes	20
T386	1079-1080	NN	denotes	%
T387	1080-1081	-RRB-	denotes	)
T388	1081-1083	,	denotes	,
T389	1083-1086	DT	denotes	the
T390	1087-1094	NN	denotes	cochlea
T373	1095-1102	VBZ	denotes	retains
T391	1103-1107	JJ	denotes	many
T393	1108-1112	JJR	denotes	more
T394	1113-1120	JJ	denotes	sensory
T392	1121-1128	NNS	denotes	neurons
T395	1129-1130	-LRB-	denotes	(
T397	1130-1132	CD	denotes	46
T396	1132-1133	NN	denotes	%
T398	1134-1142	VBN	denotes	compared
T399	1143-1145	IN	denotes	to
T400	1146-1148	CD	denotes	15
T401	1148-1149	NN	denotes	%
T402	1149-1150	-RRB-	denotes	)
T403	1151-1155	IN	denotes	than
T404	1156-1166	JJ	denotes	vestibular
T405	1167-1176	NNS	denotes	epithelia
T406	1176-1177	.	denotes	.
T407	1177-1336	sentence	denotes	Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells.
T408	1178-1182	RB	denotes	Even
T410	1183-1184	CD	denotes	6
T411	1185-1191	NNS	denotes	months
T412	1192-1195	JJ	denotes	old
T413	1196-1202	JJ	denotes	mutant
T409	1203-1207	NNS	denotes	mice
T414	1208-1212	VBP	denotes	have
T415	1213-1217	DT	denotes	some
T416	1218-1224	NNS	denotes	fibers
T417	1225-1227	IN	denotes	to
T418	1228-1231	DT	denotes	all
T420	1232-1242	JJ	denotes	vestibular
T421	1243-1250	JJ	denotes	sensory
T419	1251-1260	NNS	denotes	epithelia
T422	1261-1264	CC	denotes	and
T423	1265-1269	JJ	denotes	many
T424	1270-1274	JJR	denotes	more
T425	1275-1277	IN	denotes	to
T426	1278-1281	DT	denotes	the
T428	1282-1290	JJ	denotes	cochlear
T427	1291-1295	NN	denotes	apex
T429	1296-1301	WDT	denotes	which
T430	1302-1307	VBZ	denotes	lacks
T431	1308-1315	NN	denotes	MyoVIIa
T432	1316-1324	JJ	denotes	positive
T434	1325-1329	NN	denotes	hair
T433	1330-1335	NNS	denotes	cells
T435	1335-1336	.	denotes	.
T436	1336-1499	sentence	denotes	Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections.
T437	1337-1350	RB	denotes	Topologically
T438	1351-1360	VBN	denotes	organized
T440	1361-1368	JJ	denotes	central
T441	1369-1376	NN	denotes	cochlea
T439	1377-1388	NNS	denotes	projections
T442	1389-1394	VBP	denotes	exist
T443	1395-1397	RB	denotes	at
T444	1398-1403	RBS	denotes	least
T445	1404-1409	IN	denotes	until
T446	1410-1412	NN	denotes	P8
T447	1412-1414	,	denotes	,
T448	1414-1424	VBG	denotes	suggesting
T449	1425-1429	IN	denotes	that
T451	1430-1440	JJ	denotes	functional
T453	1441-1445	NN	denotes	hair
T452	1446-1451	NNS	denotes	cells
T454	1452-1455	VBP	denotes	are
T455	1456-1459	RB	denotes	not
T450	1460-1468	VBN	denotes	required
T456	1469-1471	TO	denotes	to
T457	1472-1481	VB	denotes	establish
T458	1482-1486	JJ	denotes	such
T459	1487-1498	NNS	denotes	projections
T460	1498-1499	.	denotes	.
T461	1499-1511	sentence	denotes	Conclusion
T462	1501-1511	NN	denotes	Conclusion
T463	1511-1669	sentence	denotes	The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth.
T464	1512-1515	DT	denotes	The
T466	1516-1523	VBN	denotes	limited
T465	1524-1534	NN	denotes	expression
T468	1535-1537	IN	denotes	of
T469	1538-1551	NNS	denotes	neurotrophins
T470	1552-1554	IN	denotes	in
T471	1555-1558	DT	denotes	the
T472	1559-1566	NN	denotes	cochlea
T473	1567-1569	IN	denotes	of
T474	1570-1575	NN	denotes	Brn3c
T475	1576-1580	JJ	denotes	null
T476	1581-1585	NNS	denotes	mice
T467	1586-1594	VBZ	denotes	suffices
T477	1595-1597	TO	denotes	to
T478	1598-1605	VB	denotes	support
T479	1606-1610	JJ	denotes	many
T481	1611-1618	JJ	denotes	sensory
T480	1619-1626	NNS	denotes	neurons
T482	1626-1628	,	denotes	,
T483	1628-1640	RB	denotes	particularly
T484	1641-1643	IN	denotes	in
T485	1644-1647	DT	denotes	the
T486	1648-1655	NN	denotes	cochlea
T487	1655-1657	,	denotes	,
T488	1657-1662	IN	denotes	until
T489	1663-1668	NN	denotes	birth
T490	1668-1669	.	denotes	.
T491	1669-1758	sentence	denotes	The molecular nature of the long term survival of apical spiral neurons remains unclear.
T492	1670-1673	DT	denotes	The
T494	1674-1683	JJ	denotes	molecular
T493	1684-1690	NN	denotes	nature
T496	1691-1693	IN	denotes	of
T497	1694-1697	DT	denotes	the
T499	1698-1702	JJ	denotes	long
T500	1703-1707	NN	denotes	term
T498	1708-1716	NN	denotes	survival
T501	1717-1719	IN	denotes	of
T502	1720-1726	JJ	denotes	apical
T503	1727-1733	JJ	denotes	spiral
T504	1734-1741	NNS	denotes	neurons
T495	1742-1749	VBZ	denotes	remains
T505	1750-1757	JJ	denotes	unclear
T506	1757-1758	.	denotes	.
T820	1771-1776	NN	denotes	Brn3c
T821	1777-1779	VBZ	denotes	is
T822	1780-1781	DT	denotes	a
T824	1782-1785	NN	denotes	POU
T825	1786-1792	NN	denotes	domain
T823	1793-1799	NN	denotes	factor
T826	1800-1804	WDT	denotes	that
T827	1805-1807	VBZ	denotes	is
T828	1808-1815	JJ	denotes	crucial
T829	1816-1819	IN	denotes	for
T830	1820-1825	JJ	denotes	inner
T831	1826-1829	JJ	denotes	ear
T833	1830-1834	NN	denotes	hair
T834	1835-1839	NN	denotes	cell
T832	1840-1851	NN	denotes	development
T835	1851-1852	.	denotes	.
T836	1852-1913	sentence	denotes	Targeted null Brn3c mutants have no mature hair cells [1,2].
T837	1853-1861	VBN	denotes	Targeted
T839	1862-1866	JJ	denotes	null
T840	1867-1872	NN	denotes	Brn3c
T838	1873-1880	NNS	denotes	mutants
T841	1881-1885	VBP	denotes	have
T842	1886-1888	DT	denotes	no
T844	1889-1895	JJ	denotes	mature
T845	1896-1900	NN	denotes	hair
T843	1901-1906	NNS	denotes	cells
T846	1907-1908	-LRB-	denotes	[
T848	1908-1909	CD	denotes	1
T849	1909-1910	,	denotes	,
T847	1910-1911	CD	denotes	2
T850	1911-1912	-RRB-	denotes	]
T851	1912-1913	.	denotes	.
T852	1913-2092	sentence	denotes	Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3].
T853	1914-1919	NN	denotes	Close
T854	1920-1931	NN	denotes	examination
T856	1932-1935	VBZ	denotes	has
T855	1936-1944	VBN	denotes	revealed
T857	1945-1949	IN	denotes	that
T859	1950-1954	DT	denotes	some
T861	1955-1956	``	denotes	'
T862	1956-1964	JJ	denotes	immature
T863	1964-1965	''	denotes	'
T864	1966-1970	NN	denotes	hair
T860	1971-1976	NNS	denotes	cells
T858	1977-1981	VBP	denotes	form
T865	1982-1984	IN	denotes	in
T866	1985-1990	NN	denotes	Brn3c
T868	1991-1995	JJ	denotes	null
T867	1996-2003	NNS	denotes	mutants
T869	2004-2007	CC	denotes	and
T870	2008-2015	VBP	denotes	express
T871	2016-2024	JJ	denotes	cellular
T872	2025-2032	NNS	denotes	markers
T873	2033-2037	JJ	denotes	such
T874	2038-2040	IN	denotes	as
T875	2041-2047	NN	denotes	Myosin
T876	2048-2050	NN	denotes	VI
T877	2051-2054	CC	denotes	and
T878	2055-2059	NN	denotes	VIIa
T879	2059-2061	,	denotes	,
T880	2061-2071	NN	denotes	calretinin
T881	2072-2075	CC	denotes	and
T882	2076-2087	NN	denotes	parvalbumin
T883	2088-2089	-LRB-	denotes	[
T884	2089-2090	CD	denotes	3
T885	2090-2091	-RRB-	denotes	]
T886	2091-2092	.	denotes	.
T887	2092-2188	sentence	denotes	Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3].
T888	2093-2104	RB	denotes	Furthermore
T890	2104-2106	,	denotes	,
T891	2106-2111	DT	denotes	these
T893	2112-2120	JJ	denotes	immature
T894	2121-2125	NN	denotes	hair
T892	2126-2131	NNS	denotes	cells
T895	2132-2134	IN	denotes	of
T896	2135-2140	NN	denotes	Brn3c
T898	2141-2145	JJ	denotes	null
T897	2146-2153	NNS	denotes	mutants
T889	2154-2161	VBP	denotes	undergo
T899	2162-2171	NN	denotes	apoptosis
T900	2172-2174	IN	denotes	in
T901	2175-2183	NNS	denotes	neonates
T902	2184-2185	-LRB-	denotes	[
T903	2185-2186	CD	denotes	3
T904	2186-2187	-RRB-	denotes	]
T905	2187-2188	.	denotes	.
T906	2188-2361	sentence	denotes	Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]).
T907	2189-2199	JJ	denotes	Consistent
T909	2200-2204	IN	denotes	with
T910	2205-2207	DT	denotes	an
T912	2208-2216	JJ	denotes	apparent
T911	2217-2224	NN	denotes	absence
T913	2225-2227	IN	denotes	of
T914	2228-2234	JJ	denotes	mature
T916	2235-2239	NN	denotes	hair
T915	2240-2245	NNS	denotes	cells
T917	2245-2247	,	denotes	,
T918	2247-2254	JJ	denotes	initial
T919	2255-2259	NN	denotes	work
T908	2260-2269	VBD	denotes	suggested
T920	2270-2274	IN	denotes	that
T922	2275-2278	DT	denotes	all
T923	2279-2289	JJ	denotes	vestibular
T924	2290-2293	CC	denotes	and
T925	2294-2298	DT	denotes	most
T926	2299-2305	JJ	denotes	spiral
T928	2306-2314	NN	denotes	ganglion
T927	2315-2320	NNS	denotes	cells
T929	2321-2324	VBP	denotes	are
T921	2325-2329	VBN	denotes	lost
T930	2330-2332	IN	denotes	by
T931	2333-2342	JJ	denotes	postnatal
T932	2343-2346	NN	denotes	day
T933	2347-2349	CD	denotes	14
T934	2350-2351	-LRB-	denotes	(
T935	2351-2354	NN	denotes	P14
T936	2354-2355	:	denotes	;
T937	2356-2357	-LRB-	denotes	[
T938	2357-2358	CD	denotes	1
T939	2358-2359	-RRB-	denotes	]
T940	2359-2360	-RRB-	denotes	)
T941	2360-2361	.	denotes	.
T942	2361-2506	sentence	denotes	However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost.
T943	2362-2369	RB	denotes	However
T945	2369-2371	,	denotes	,
T946	2371-2375	RBR	denotes	more
T948	2376-2384	JJ	denotes	detailed
T947	2385-2399	NN	denotes	quantification
T949	2400-2402	IN	denotes	by
T950	2403-2409	NNS	denotes	others
T951	2410-2411	-LRB-	denotes	[
T952	2411-2412	CD	denotes	3
T953	2412-2413	-RRB-	denotes	]
T944	2414-2422	VBD	denotes	reported
T954	2423-2427	IN	denotes	that
T956	2428-2430	IN	denotes	at
T957	2431-2433	NN	denotes	P4
T958	2434-2439	IN	denotes	about
T959	2440-2442	CD	denotes	77
T960	2442-2443	NN	denotes	%
T961	2444-2446	IN	denotes	of
T962	2447-2457	JJ	denotes	vestibular
T963	2458-2465	NNS	denotes	neurons
T964	2466-2469	CC	denotes	and
T965	2470-2474	RB	denotes	only
T966	2475-2477	CD	denotes	29
T967	2477-2478	NN	denotes	%
T968	2479-2481	IN	denotes	of
T969	2482-2488	JJ	denotes	spiral
T970	2489-2496	NNS	denotes	neurons
T971	2497-2500	VBP	denotes	are
T955	2501-2505	VBN	denotes	lost
T972	2505-2506	.	denotes	.
T973	2506-2577	sentence	denotes	It was suggested that there is possibly a complete loss in adults [3].
T974	2507-2509	PRP	denotes	It
T976	2510-2513	VBD	denotes	was
T975	2514-2523	VBN	denotes	suggested
T977	2524-2528	IN	denotes	that
T979	2529-2534	EX	denotes	there
T978	2535-2537	VBZ	denotes	is
T980	2538-2546	RB	denotes	possibly
T981	2547-2548	DT	denotes	a
T983	2549-2557	JJ	denotes	complete
T982	2558-2562	NN	denotes	loss
T984	2563-2565	IN	denotes	in
T985	2566-2572	NNS	denotes	adults
T986	2573-2574	-LRB-	denotes	[
T987	2574-2575	CD	denotes	3
T988	2575-2576	-RRB-	denotes	]
T989	2576-2577	.	denotes	.
T990	2577-2711	sentence	denotes	Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants.
T991	2578-2583	RB	denotes	Other
T993	2584-2588	IN	denotes	than
T994	2589-2594	DT	denotes	these
T996	2595-2606	JJ	denotes	preliminary
T995	2607-2617	NNS	denotes	statements
T997	2617-2619	,	denotes	,
T998	2619-2621	DT	denotes	no
T999	2622-2626	NN	denotes	data
T992	2627-2633	VBZ	denotes	exists
T1000	2634-2644	VBG	denotes	concerning
T1001	2645-2648	DT	denotes	the
T1003	2649-2657	JJ	denotes	detailed
T1002	2658-2665	NN	denotes	pattern
T1004	2666-2668	IN	denotes	of
T1005	2669-2673	NN	denotes	loss
T1006	2674-2676	IN	denotes	of
T1007	2677-2688	NN	denotes	innervation
T1008	2689-2691	IN	denotes	in
T1009	2692-2697	NN	denotes	Brn3c
T1010	2698-2702	JJ	denotes	null
T1011	2703-2710	NNS	denotes	mutants
T1012	2710-2711	.	denotes	.
T1013	2711-2930	sentence	denotes	The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond.
T1014	2712-2715	DT	denotes	The
T1016	2716-2723	JJ	denotes	initial
T1015	2724-2735	NN	denotes	development
T1018	2736-2739	CC	denotes	and
T1019	2740-2747	JJ	denotes	partial
T1020	2748-2763	NN	denotes	differentiation
T1021	2764-2766	IN	denotes	of
T1022	2767-2771	NN	denotes	hair
T1023	2772-2777	NNS	denotes	cells
T1024	2778-2780	IN	denotes	in
T1025	2781-2786	NN	denotes	Brn3c
T1026	2787-2794	NNS	denotes	mutants
T1027	2795-2800	MD	denotes	could
T1028	2801-2809	RB	denotes	possibly
T1017	2810-2814	VB	denotes	lead
T1029	2815-2817	IN	denotes	to
T1030	2818-2822	DT	denotes	some
T1032	2823-2835	NN	denotes	neurotrophin
T1031	2836-2846	NN	denotes	expression
T1033	2847-2849	IN	denotes	in
T1034	2850-2855	DT	denotes	these
T1035	2856-2861	NNS	denotes	cells
T1036	2862-2864	TO	denotes	to
T1037	2865-2872	VB	denotes	sustain
T1038	2873-2880	JJ	denotes	sensory
T1039	2881-2888	NNS	denotes	neurons
T1040	2889-2896	IN	denotes	through
T1041	2897-2906	JJ	denotes	embryonic
T1042	2907-2918	NN	denotes	development
T1043	2919-2922	CC	denotes	and
T1044	2923-2929	RB	denotes	beyond
T1045	2929-2930	.	denotes	.
T1046	2930-3130	sentence	denotes	Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5].
T1047	2931-2935	NNS	denotes	Data
T1049	2936-2938	IN	denotes	on
T1050	2939-2946	JJ	denotes	various
T1052	2947-2953	JJ	denotes	single
T1054	2954-2957	CC	denotes	and
T1055	2958-2966	NN	denotes	compound
T1053	2967-2979	NN	denotes	neurotrophin
T1056	2980-2984	JJ	denotes	null
T1051	2985-2992	NNS	denotes	mutants
T1057	2993-2997	VBP	denotes	have
T1048	2998-3003	VBN	denotes	shown
T1058	3004-3008	IN	denotes	that
T1060	3009-3012	DT	denotes	the
T1061	3013-3017	NN	denotes	loss
T1062	3018-3020	IN	denotes	of
T1063	3021-3022	DT	denotes	a
T1065	3023-3031	JJ	denotes	specific
T1064	3032-3044	NN	denotes	neurotrophin
T1059	3045-3050	VBZ	denotes	leads
T1066	3051-3053	IN	denotes	to
T1067	3054-3067	RB	denotes	topologically
T1068	3068-3078	JJ	denotes	restricted
T1069	3079-3083	NN	denotes	loss
T1070	3084-3086	IN	denotes	of
T1071	3087-3094	JJ	denotes	sensory
T1072	3095-3102	NNS	denotes	neurons
T1073	3103-3105	IN	denotes	in
T1074	3106-3109	DT	denotes	the
T1076	3110-3119	JJ	denotes	embryonic
T1075	3120-3123	NN	denotes	ear
T1077	3124-3125	-LRB-	denotes	[
T1079	3125-3126	CD	denotes	4
T1080	3126-3127	,	denotes	,
T1078	3127-3128	CD	denotes	5
T1081	3128-3129	-RRB-	denotes	]
T1082	3129-3130	.	denotes	.
T1083	3130-3258	sentence	denotes	Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells.
T1084	3131-3135	JJ	denotes	Such
T1086	3136-3145	JJ	denotes	selective
T1085	3146-3150	NN	denotes	loss
T1088	3151-3153	IN	denotes	in
T1089	3154-3159	NN	denotes	Brn3c
T1091	3160-3164	JJ	denotes	null
T1090	3165-3172	NNS	denotes	mutants
T1092	3173-3178	MD	denotes	would
T1093	3179-3188	RB	denotes	therefore
T1087	3189-3197	VB	denotes	indicate
T1094	3198-3207	NN	denotes	reduction
T1095	3208-3210	IN	denotes	of
T1096	3211-3212	DT	denotes	a
T1098	3213-3221	JJ	denotes	specific
T1097	3222-3234	NN	denotes	neurotrophin
T1099	3235-3237	IN	denotes	in
T1100	3238-3246	JJ	denotes	immature
T1102	3247-3251	NN	denotes	hair
T1101	3252-3257	NNS	denotes	cells
T1103	3257-3258	.	denotes	.
T1104	3258-3399	sentence	denotes	Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7].
T1105	3259-3267	RB	denotes	Moreover
T1107	3267-3269	,	denotes	,
T1108	3269-3275	JJ	denotes	recent
T1109	3276-3280	NN	denotes	work
T1106	3281-3286	VBZ	denotes	shows
T1110	3287-3291	IN	denotes	that
T1112	3292-3294	IN	denotes	in
T1113	3295-3302	NNS	denotes	embryos
T1114	3303-3305	NN	denotes	NT
T1115	3305-3306	HYPH	denotes	-
T1116	3306-3307	CD	denotes	3
T1117	3308-3310	VBZ	denotes	is
T1118	3311-3320	RB	denotes	primarily
T1111	3321-3330	VBN	denotes	expressed
T1119	3331-3333	IN	denotes	in
T1120	3334-3344	VBG	denotes	supporting
T1121	3345-3350	NNS	denotes	cells
T1122	3350-3352	,	denotes	,
T1123	3352-3358	VBG	denotes	moving
T1124	3359-3363	RB	denotes	only
T1125	3364-3370	IN	denotes	around
T1126	3371-3376	NN	denotes	birth
T1127	3377-3381	IN	denotes	into
T1128	3382-3386	NN	denotes	hair
T1129	3387-3392	NNS	denotes	cells
T1130	3393-3394	-LRB-	denotes	[
T1132	3394-3395	CD	denotes	6
T1133	3395-3396	,	denotes	,
T1131	3396-3397	CD	denotes	7
T1134	3397-3398	-RRB-	denotes	]
T1135	3398-3399	.	denotes	.
T1136	3399-3677	sentence	denotes	In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place.
T1137	3400-3402	IN	denotes	In
T1139	3403-3407	NN	denotes	fact
T1140	3407-3409	,	denotes	,
T1141	3409-3412	DT	denotes	the
T1143	3413-3422	JJ	denotes	selective
T1142	3423-3427	NN	denotes	loss
T1144	3428-3430	IN	denotes	of
T1145	3431-3441	JJ	denotes	vestibular
T1146	3442-3444	IN	denotes	as
T1147	3445-3453	VBN	denotes	compared
T1148	3454-3456	IN	denotes	to
T1149	3457-3465	JJ	denotes	cochlear
T1150	3466-3473	JJ	denotes	sensory
T1151	3474-3481	NNS	denotes	neurons
T1152	3482-3483	-LRB-	denotes	(
T1154	3483-3485	CD	denotes	77
T1153	3485-3486	NN	denotes	%
T1155	3487-3493	CC	denotes	versus
T1156	3494-3496	CD	denotes	29
T1157	3496-3497	NN	denotes	%
T1158	3497-3498	:	denotes	;
T1159	3499-3500	-LRB-	denotes	[
T1160	3500-3501	CD	denotes	3
T1161	3501-3502	-RRB-	denotes	]
T1162	3502-3503	-RRB-	denotes	)
T1138	3504-3512	VBZ	denotes	suggests
T1163	3513-3517	IN	denotes	that
T1165	3518-3520	NN	denotes	NT
T1167	3520-3521	HYPH	denotes	-
T1168	3521-3522	CD	denotes	3
T1166	3523-3533	NN	denotes	expression
T1169	3534-3537	MD	denotes	may
T1164	3538-3540	VB	denotes	be
T1170	3541-3545	RBR	denotes	less
T1171	3546-3559	VBN	denotes	downregulated
T1172	3560-3562	IN	denotes	in
T1173	3563-3568	NN	denotes	Brn3c
T1175	3569-3573	JJ	denotes	null
T1174	3574-3581	NNS	denotes	mutants
T1176	3582-3586	IN	denotes	than
T1177	3587-3591	NN	denotes	BDNF
T1178	3592-3593	-LRB-	denotes	[
T1180	3593-3594	CD	denotes	6
T1181	3594-3595	,	denotes	,
T1182	3595-3596	CD	denotes	8
T1183	3596-3597	,	denotes	,
T1179	3597-3598	CD	denotes	9
T1184	3598-3599	-RRB-	denotes	]
T1185	3599-3601	,	denotes	,
T1186	3601-3609	VBN	denotes	provided
T1187	3610-3614	IN	denotes	that
T1189	3615-3617	RB	denotes	at
T1190	3618-3623	RBS	denotes	least
T1192	3624-3628	DT	denotes	some
T1191	3629-3644	NN	denotes	differentiation
T1193	3645-3647	IN	denotes	of
T1194	3648-3658	VBG	denotes	supporting
T1195	3659-3664	NNS	denotes	cells
T1188	3665-3670	VBZ	denotes	takes
T1196	3671-3676	NN	denotes	place
T1197	3676-3677	.	denotes	.
T1198	3677-3830	sentence	denotes	In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11].
T1199	3678-3680	IN	denotes	In
T1201	3681-3684	DT	denotes	the
T1202	3685-3688	NN	denotes	ear
T1203	3689-3690	-LRB-	denotes	[
T1204	3690-3691	CD	denotes	4
T1205	3691-3692	-RRB-	denotes	]
T1206	3693-3695	RB	denotes	as
T1208	3696-3700	RB	denotes	well
T1207	3701-3703	IN	denotes	as
T1209	3704-3713	RB	denotes	elsewhere
T1211	3714-3715	-LRB-	denotes	[
T1210	3715-3717	CD	denotes	10
T1212	3717-3718	-RRB-	denotes	]
T1213	3719-3732	NNS	denotes	neurotrophins
T1214	3733-3736	VBP	denotes	are
T1215	3737-3750	RB	denotes	progressively
T1200	3751-3764	VBN	denotes	downregulated
T1216	3765-3767	IN	denotes	in
T1217	3768-3777	JJ	denotes	postnatal
T1218	3778-3785	NNS	denotes	mammals
T1219	3786-3789	CC	denotes	and
T1220	3790-3798	RB	denotes	possibly
T1221	3799-3807	VBN	denotes	replaced
T1222	3808-3810	IN	denotes	by
T1223	3811-3816	JJ	denotes	other
T1224	3817-3824	NNS	denotes	factors
T1225	3825-3826	-LRB-	denotes	[
T1226	3826-3828	CD	denotes	11
T1227	3828-3829	-RRB-	denotes	]
T1228	3829-3830	.	denotes	.
T1229	3830-3954	sentence	denotes	We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF.
T1230	3831-3833	PRP	denotes	We
T1232	3834-3838	VBP	denotes	have
T1231	3839-3851	VBN	denotes	investigated
T1233	3852-3854	IN	denotes	in
T1234	3855-3861	NN	denotes	detail
T1235	3862-3865	DT	denotes	the
T1236	3866-3873	NN	denotes	pattern
T1237	3874-3876	IN	denotes	of
T1238	3877-3888	NN	denotes	innervation
T1239	3889-3891	IN	denotes	in
T1240	3892-3895	DT	denotes	the
T1242	3896-3901	NN	denotes	Brn3c
T1241	3902-3909	NNS	denotes	mutants
T1243	3909-3911	,	denotes	,
T1244	3911-3913	RB	denotes	as
T1246	3914-3918	RB	denotes	well
T1245	3919-3921	IN	denotes	as
T1247	3922-3925	DT	denotes	the
T1248	3926-3936	NN	denotes	expression
T1249	3937-3939	IN	denotes	of
T1250	3940-3942	NN	denotes	NT
T1251	3942-3943	HYPH	denotes	-
T1252	3943-3944	CD	denotes	3
T1253	3945-3948	CC	denotes	and
T1254	3949-3953	NN	denotes	BDNF
T1255	3953-3954	.	denotes	.
T1256	3954-4145	sentence	denotes	We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals.
T1257	3955-3957	PRP	denotes	We
T1258	3958-3962	VBP	denotes	want
T1259	3963-3965	TO	denotes	to
T1260	3966-3974	VB	denotes	evaluate
T1261	3975-3976	DT	denotes	a
T1263	3977-3985	JJ	denotes	possible
T1262	3986-3997	NN	denotes	correlation
T1264	3998-4005	IN	denotes	between
T1265	4006-4009	DT	denotes	the
T1266	4010-4018	NN	denotes	topology
T1267	4019-4021	IN	denotes	of
T1268	4022-4029	JJ	denotes	sensory
T1269	4030-4036	NN	denotes	neuron
T1270	4037-4041	NN	denotes	loss
T1271	4042-4045	CC	denotes	and
T1272	4046-4053	NN	denotes	absence
T1273	4054-4056	IN	denotes	of
T1274	4057-4058	DT	denotes	a
T1276	4059-4067	JJ	denotes	specific
T1275	4068-4080	NN	denotes	neurotrophin
T1277	4081-4083	CC	denotes	or
T1278	4084-4095	JJ	denotes	topological
T1279	4096-4100	NN	denotes	loss
T1280	4101-4103	IN	denotes	of
T1281	4104-4108	NN	denotes	hair
T1282	4109-4114	NNS	denotes	cells
T1283	4115-4117	IN	denotes	at
T1284	4118-4123	NN	denotes	birth
T1285	4124-4127	CC	denotes	and
T1286	4128-4130	IN	denotes	in
T1287	4131-4136	JJR	denotes	older
T1288	4137-4144	NNS	denotes	animals
T1289	4144-4145	.	denotes	.
T1290	4145-4271	sentence	denotes	This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12].
T1291	4146-4150	DT	denotes	This
T1292	4151-4162	NN	denotes	information
T1294	4163-4168	MD	denotes	could
T1293	4169-4171	VB	denotes	be
T1295	4172-4181	JJ	denotes	important
T1296	4182-4185	IN	denotes	for
T1297	4186-4188	DT	denotes	an
T1299	4189-4191	IN	denotes	in
T1300	4191-4192	HYPH	denotes	-
T1301	4192-4197	NN	denotes	depth
T1298	4198-4208	NN	denotes	evaluation
T1302	4209-4211	IN	denotes	of
T1303	4212-4215	DT	denotes	the
T1305	4216-4221	JJ	denotes	human
T1304	4222-4230	NN	denotes	deafness
T1306	4231-4238	VBN	denotes	related
T1307	4239-4241	IN	denotes	to
T1308	4242-4245	DT	denotes	the
T1310	4246-4252	NN	denotes	Pou4f3
T1309	4253-4257	NN	denotes	gene
T1311	4257-4259	,	denotes	,
T1312	4259-4265	NN	denotes	DFNA15
T1313	4266-4267	-LRB-	denotes	[
T1314	4267-4269	CD	denotes	12
T1315	4269-4270	-RRB-	denotes	]
T1316	4270-4271	.	denotes	.
T1317	4271-4420	sentence	denotes	We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice.
T1318	4272-4274	PRP	denotes	We
T1319	4275-4281	VBP	denotes	report
T1320	4282-4286	RB	denotes	here
T1321	4287-4291	JJ	denotes	long
T1322	4292-4296	NN	denotes	term
T1323	4297-4306	NN	denotes	retention
T1324	4307-4309	IN	denotes	of
T1325	4310-4318	JJ	denotes	cochlear
T1327	4319-4326	JJ	denotes	sensory
T1326	4327-4334	NNS	denotes	neurons
T1328	4335-4338	IN	denotes	for
T1329	4339-4341	RB	denotes	at
T1331	4342-4347	RBS	denotes	least
T1330	4348-4349	CD	denotes	6
T1332	4350-4356	NNS	denotes	months
T1333	4356-4358	,	denotes	,
T1334	4358-4360	IN	denotes	in
T1336	4361-4371	JJ	denotes	particular
T1335	4372-4374	IN	denotes	in
T1337	4375-4378	DT	denotes	the
T1339	4379-4387	JJ	denotes	cochlear
T1338	4388-4392	NN	denotes	apex
T1340	4392-4394	,	denotes	,
T1341	4394-4396	IN	denotes	in
T1342	4397-4402	NN	denotes	Brn3c
T1343	4403-4407	JJ	denotes	null
T1345	4408-4414	JJ	denotes	mutant
T1344	4415-4419	NNS	denotes	mice
T1346	4419-4420	.	denotes	.
T1347	4420-4639	sentence	denotes	This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea.
T1348	4421-4425	DT	denotes	This
T1349	4426-4435	NN	denotes	retention
T1351	4436-4438	IN	denotes	of
T1352	4439-4448	NNS	denotes	afferents
T1353	4449-4452	CC	denotes	and
T1354	4453-4462	NNS	denotes	efferents
T1350	4463-4465	VBZ	denotes	is
T1355	4466-4475	JJ	denotes	unrelated
T1356	4476-4478	IN	denotes	to
T1357	4479-4483	NN	denotes	hair
T1358	4484-4488	NN	denotes	cell
T1359	4489-4504	NN	denotes	differentiation
T1360	4505-4507	IN	denotes	as
T1362	4508-4511	RB	denotes	not
T1364	4512-4516	RB	denotes	even
T1365	4517-4525	JJ	denotes	immature
T1366	4526-4530	NN	denotes	hair
T1363	4531-4536	NNS	denotes	cells
T1367	4537-4540	MD	denotes	can
T1368	4541-4543	VB	denotes	be
T1361	4544-4552	VBN	denotes	detected
T1369	4553-4555	IN	denotes	at
T1370	4556-4561	JJ	denotes	early
T1372	4562-4571	JJ	denotes	postnatal
T1371	4572-4578	NNS	denotes	stages
T1373	4579-4583	IN	denotes	with
T1374	4584-4590	NN	denotes	MyoVII
T1375	4591-4610	NN	denotes	immunocytochemistry
T1376	4611-4613	IN	denotes	in
T1377	4614-4618	DT	denotes	this
T1378	4619-4623	NN	denotes	part
T1379	4624-4626	IN	denotes	of
T1380	4627-4630	DT	denotes	the
T1381	4631-4638	NN	denotes	cochlea
T1382	4638-4639	.	denotes	.
T1383	4639-4797	sentence	denotes	This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4].
T1384	4640-4644	DT	denotes	This
T1385	4645-4654	NN	denotes	retention
T1387	4655-4657	IN	denotes	of
T1388	4658-4664	JJ	denotes	apical
T1390	4665-4671	JJ	denotes	spiral
T1389	4672-4679	NNS	denotes	neurons
T1386	4680-4682	VBZ	denotes	is
T1391	4683-4687	RB	denotes	also
T1392	4688-4695	RB	denotes	largely
T1393	4696-4705	JJ	denotes	unrelated
T1394	4706-4708	IN	denotes	to
T1395	4709-4722	NNS	denotes	neurotrophins
T1396	4723-4728	WDT	denotes	which
T1398	4729-4732	VBP	denotes	are
T1397	4733-4738	VBN	denotes	known
T1399	4739-4741	TO	denotes	to
T1401	4742-4744	VB	denotes	be
T1400	4745-4752	VBN	denotes	reduced
T1402	4753-4755	IN	denotes	in
T1403	4756-4761	PRP$	denotes	their
T1404	4762-4772	NN	denotes	expression
T1405	4773-4775	IN	denotes	in
T1406	4776-4784	JJ	denotes	neonatal
T1407	4785-4792	NNS	denotes	rodents
T1408	4793-4794	-LRB-	denotes	[
T1409	4794-4795	CD	denotes	4
T1410	4795-4796	-RRB-	denotes	]
T1411	4796-4797	.	denotes	.
T1476	4807-4809	TO	denotes	To
T1477	4810-4820	VB	denotes	appreciate
T1479	4821-4824	DT	denotes	the
T1480	4825-4832	NNS	denotes	effects
T1481	4833-4835	IN	denotes	of
T1482	4836-4839	DT	denotes	the
T1484	4840-4845	NN	denotes	Brn3c
T1485	4846-4850	JJ	denotes	null
T1483	4851-4859	NN	denotes	mutation
T1486	4860-4862	IN	denotes	on
T1487	4863-4866	DT	denotes	the
T1488	4867-4874	NN	denotes	pattern
T1489	4875-4877	IN	denotes	of
T1490	4878-4881	DT	denotes	the
T1492	4882-4887	JJ	denotes	inner
T1493	4888-4891	NN	denotes	ear
T1491	4892-4903	NN	denotes	innervation
T1494	4903-4905	,	denotes	,
T1495	4905-4907	PRP	denotes	we
T1496	4908-4913	RB	denotes	first
T1478	4914-4918	VBP	denotes	want
T1497	4919-4921	TO	denotes	to
T1498	4922-4929	VB	denotes	present
T1499	4930-4933	DT	denotes	the
T1500	4934-4941	NNS	denotes	effects
T1501	4942-4944	IN	denotes	of
T1502	4945-4949	NN	denotes	BDNF
T1504	4950-4953	CC	denotes	and
T1505	4954-4956	NN	denotes	NT
T1506	4956-4957	HYPH	denotes	-
T1507	4957-4958	CD	denotes	3
T1508	4959-4963	JJ	denotes	null
T1503	4964-4973	NNS	denotes	mutations
T1509	4974-4976	IN	denotes	at
T1510	4977-4982	NN	denotes	birth
T1511	4983-4984	-LRB-	denotes	[
T1513	4984-4985	CD	denotes	6
T1514	4985-4986	,	denotes	,
T1515	4986-4988	CD	denotes	13
T1516	4988-4989	,	denotes	,
T1512	4989-4991	CD	denotes	14
T1517	4991-4992	-RRB-	denotes	]
T1518	4992-4993	.	denotes	.
T1519	4993-5170	sentence	denotes	Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea.
T1520	4994-4998	JJ	denotes	Null
T1521	4999-5006	NNS	denotes	mutants
T1523	5007-5009	IN	denotes	of
T1524	5010-5014	NN	denotes	BDNF
T1525	5015-5017	CC	denotes	or
T1526	5018-5021	PRP$	denotes	its
T1527	5022-5030	NN	denotes	receptor
T1528	5031-5035	NN	denotes	trkB
T1522	5036-5040	VBP	denotes	lose
T1529	5041-5044	DT	denotes	all
T1530	5045-5056	NN	denotes	innervation
T1531	5057-5059	IN	denotes	to
T1532	5060-5063	DT	denotes	the
T1534	5064-5076	JJ	denotes	semicircular
T1533	5077-5083	NNS	denotes	canals
T1535	5084-5087	CC	denotes	and
T1536	5088-5092	VBP	denotes	have
T1537	5093-5094	DT	denotes	a
T1539	5095-5102	VBN	denotes	reduced
T1538	5103-5114	NN	denotes	innervation
T1540	5115-5117	IN	denotes	to
T1541	5118-5121	DT	denotes	the
T1542	5122-5129	NN	denotes	utricle
T1543	5129-5131	,	denotes	,
T1544	5131-5138	NN	denotes	saccule
T1545	5139-5142	CC	denotes	and
T1546	5143-5149	JJ	denotes	apical
T1547	5150-5154	NN	denotes	turn
T1548	5155-5157	IN	denotes	of
T1549	5158-5161	DT	denotes	the
T1550	5162-5169	NN	denotes	cochlea
T1551	5169-5170	.	denotes	.
T1552	5170-5367	sentence	denotes	In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip.
T1553	5171-5173	IN	denotes	In
T1555	5174-5182	NN	denotes	contrast
T1556	5182-5184	,	denotes	,
T1557	5184-5188	JJ	denotes	null
T1558	5189-5198	NNS	denotes	mutations
T1559	5199-5201	IN	denotes	of
T1560	5202-5208	CC	denotes	either
T1561	5209-5211	NN	denotes	NT
T1562	5211-5212	HYPH	denotes	-
T1563	5212-5213	CD	denotes	3
T1564	5214-5216	CC	denotes	or
T1565	5217-5220	PRP$	denotes	its
T1566	5221-5229	NN	denotes	receptor
T1567	5230-5234	NN	denotes	trkC
T1554	5235-5241	VBP	denotes	result
T1568	5242-5244	IN	denotes	in
T1569	5245-5249	NN	denotes	loss
T1570	5250-5252	IN	denotes	of
T1571	5253-5259	JJ	denotes	spiral
T1572	5260-5267	NNS	denotes	neurons
T1573	5268-5270	IN	denotes	in
T1574	5271-5274	DT	denotes	the
T1576	5275-5280	JJ	denotes	basal
T1575	5281-5285	NN	denotes	turn
T1577	5286-5290	IN	denotes	with
T1578	5291-5300	NN	denotes	formation
T1579	5301-5303	IN	denotes	of
T1580	5304-5306	DT	denotes	an
T1582	5307-5312	JJ	denotes	inner
T1583	5313-5319	JJ	denotes	spiral
T1581	5320-5326	NN	denotes	bundle
T1584	5327-5329	IN	denotes	of
T1585	5330-5339	NNS	denotes	afferents
T1586	5340-5349	VBG	denotes	extending
T1587	5350-5352	IN	denotes	to
T1588	5353-5356	DT	denotes	the
T1590	5357-5362	JJ	denotes	basal
T1589	5363-5366	NN	denotes	tip
T1591	5366-5367	.	denotes	.
T1592	5367-5558	sentence	denotes	Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss.
T1593	5368-5371	PRP$	denotes	Our
T1595	5372-5376	JJ	denotes	null
T1594	5377-5387	NN	denotes	hypothesis
T1597	5388-5391	IN	denotes	for
T1598	5392-5396	DT	denotes	this
T1599	5397-5402	NN	denotes	study
T1600	5403-5408	MD	denotes	would
T1596	5409-5411	VB	denotes	be
T1601	5412-5416	IN	denotes	that
T1603	5417-5422	NN	denotes	Brn3c
T1605	5423-5427	JJ	denotes	null
T1604	5428-5432	NNS	denotes	mice
T1602	5433-5437	VBP	denotes	show
T1606	5438-5444	JJ	denotes	severe
T1608	5445-5456	VBN	denotes	compromised
T1607	5457-5467	NN	denotes	production
T1609	5468-5470	IN	denotes	of
T1610	5471-5476	DT	denotes	these
T1611	5477-5490	NNS	denotes	neurotrophins
T1612	5491-5494	CC	denotes	and
T1613	5495-5501	MD	denotes	should
T1615	5502-5511	RB	denotes	therefore
T1614	5512-5516	VB	denotes	show
T1616	5517-5518	DT	denotes	a
T1618	5519-5529	JJ	denotes	comparable
T1617	5530-5537	NN	denotes	pattern
T1619	5538-5540	IN	denotes	of
T1620	5541-5546	NN	denotes	nerve
T1621	5547-5552	NN	denotes	fiber
T1622	5553-5557	NN	denotes	loss
T1623	5557-5558	.	denotes	.
T1849	5579-5581	IN	denotes	at
T1850	5582-5587	NN	denotes	birth
T1851	5588-5589	-LRB-	denotes	(
T1852	5589-5591	NN	denotes	P0
T1853	5591-5592	-RRB-	denotes	)
T1854	5592-5764	sentence	denotes	Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13,15].
T1855	5593-5603	JJ	denotes	Vestibular
T1856	5604-5611	NNS	denotes	ganglia
T1857	5612-5615	VBP	denotes	are
T1858	5616-5623	JJR	denotes	smaller
T1859	5624-5626	IN	denotes	in
T1860	5627-5632	NN	denotes	Brn3c
T1862	5633-5637	JJ	denotes	null
T1861	5638-5645	NNS	denotes	mutants
T1863	5646-5647	-LRB-	denotes	(
T1865	5647-5651	NN	denotes	Fig.
T1864	5652-5654	NN	denotes	1b
T1866	5654-5655	-RRB-	denotes	)
T1867	5656-5660	IN	denotes	than
T1868	5661-5663	IN	denotes	in
T1869	5664-5671	NN	denotes	control
T1870	5672-5683	NNS	denotes	littermates
T1871	5684-5685	-LRB-	denotes	(
T1873	5685-5689	NN	denotes	Fig.
T1872	5690-5692	NN	denotes	1a
T1874	5692-5693	-RRB-	denotes	)
T1875	5693-5695	,	denotes	,
T1876	5695-5698	CC	denotes	but
T1877	5699-5705	JJR	denotes	larger
T1878	5706-5710	IN	denotes	than
T1879	5711-5713	IN	denotes	in
T1880	5714-5718	NN	denotes	BDNF
T1882	5719-5721	CC	denotes	or
T1883	5722-5726	NN	denotes	trkB
T1881	5727-5731	JJ	denotes	null
T1884	5732-5739	NNS	denotes	mutants
T1885	5740-5742	IN	denotes	of
T1886	5743-5746	DT	denotes	the
T1888	5747-5751	JJ	denotes	same
T1887	5752-5755	NN	denotes	age
T1889	5756-5757	-LRB-	denotes	[
T1891	5757-5759	CD	denotes	13
T1892	5759-5760	,	denotes	,
T1890	5760-5762	CD	denotes	15
T1893	5762-5763	-RRB-	denotes	]
T1894	5763-5764	.	denotes	.
T1895	5764-5889	sentence	denotes	The reduction in apparent size of the vestibular ganglia is in agreement with quantitative data published previously [3,13].
T1896	5765-5768	DT	denotes	The
T1897	5769-5778	NN	denotes	reduction
T1899	5779-5781	IN	denotes	in
T1900	5782-5790	JJ	denotes	apparent
T1901	5791-5795	NN	denotes	size
T1902	5796-5798	IN	denotes	of
T1903	5799-5802	DT	denotes	the
T1905	5803-5813	JJ	denotes	vestibular
T1904	5814-5821	NNS	denotes	ganglia
T1898	5822-5824	VBZ	denotes	is
T1906	5825-5827	IN	denotes	in
T1907	5828-5837	NN	denotes	agreement
T1908	5838-5842	IN	denotes	with
T1909	5843-5855	JJ	denotes	quantitative
T1910	5856-5860	NNS	denotes	data
T1911	5861-5870	VBN	denotes	published
T1912	5871-5881	RB	denotes	previously
T1913	5882-5883	-LRB-	denotes	[
T1915	5883-5884	CD	denotes	3
T1916	5884-5885	,	denotes	,
T1914	5885-5887	CD	denotes	13
T1917	5887-5888	-RRB-	denotes	]
T1918	5888-5889	.	denotes	.
T1919	5889-6061	sentence	denotes	These data suggest a loss of 80–85% of vestibular sensory neurons in BDNF and trkB null mutants [13] and of 77% of vestibular sensory neurons in P4 Brn3c null mutants [3].
T1920	5890-5895	DT	denotes	These
T1921	5896-5900	NNS	denotes	data
T1922	5901-5908	VBP	denotes	suggest
T1923	5909-5910	DT	denotes	a
T1924	5911-5915	NN	denotes	loss
T1925	5916-5918	IN	denotes	of
T1926	5919-5921	CD	denotes	80
T1928	5921-5922	SYM	denotes	–
T1927	5922-5924	CD	denotes	85
T1929	5924-5925	NN	denotes	%
T1930	5926-5928	IN	denotes	of
T1931	5929-5939	JJ	denotes	vestibular
T1933	5940-5947	JJ	denotes	sensory
T1932	5948-5955	NNS	denotes	neurons
T1934	5956-5958	IN	denotes	in
T1935	5959-5963	NN	denotes	BDNF
T1937	5964-5967	CC	denotes	and
T1938	5968-5972	NN	denotes	trkB
T1936	5973-5977	JJ	denotes	null
T1939	5978-5985	NNS	denotes	mutants
T1940	5986-5987	-LRB-	denotes	[
T1941	5987-5989	CD	denotes	13
T1942	5989-5990	-RRB-	denotes	]
T1943	5991-5994	CC	denotes	and
T1944	5995-5997	IN	denotes	of
T1945	5998-6000	CD	denotes	77
T1946	6000-6001	NN	denotes	%
T1947	6002-6004	IN	denotes	of
T1948	6005-6015	JJ	denotes	vestibular
T1950	6016-6023	JJ	denotes	sensory
T1949	6024-6031	NNS	denotes	neurons
T1951	6032-6034	IN	denotes	in
T1952	6035-6037	NN	denotes	P4
T1953	6038-6043	NN	denotes	Brn3c
T1954	6044-6048	JJ	denotes	null
T1955	6049-6056	NNS	denotes	mutants
T1956	6057-6058	-LRB-	denotes	[
T1957	6058-6059	CD	denotes	3
T1958	6059-6060	-RRB-	denotes	]
T1959	6060-6061	.	denotes	.
T1960	6061-6200	sentence	denotes	Thus, the size reduction in the vestibular sensory ganglion could be compatible with a loss of BDNF production in the immature hair cells.
T1961	6062-6066	RB	denotes	Thus
T1963	6066-6068	,	denotes	,
T1964	6068-6071	DT	denotes	the
T1966	6072-6076	NN	denotes	size
T1965	6077-6086	NN	denotes	reduction
T1967	6087-6089	IN	denotes	in
T1968	6090-6093	DT	denotes	the
T1970	6094-6104	JJ	denotes	vestibular
T1971	6105-6112	JJ	denotes	sensory
T1969	6113-6121	NN	denotes	ganglion
T1972	6122-6127	MD	denotes	could
T1962	6128-6130	VB	denotes	be
T1973	6131-6141	JJ	denotes	compatible
T1974	6142-6146	IN	denotes	with
T1975	6147-6148	DT	denotes	a
T1976	6149-6153	NN	denotes	loss
T1977	6154-6156	IN	denotes	of
T1978	6157-6161	NN	denotes	BDNF
T1979	6162-6172	NN	denotes	production
T1980	6173-6175	IN	denotes	in
T1981	6176-6179	DT	denotes	the
T1983	6180-6188	JJ	denotes	immature
T1984	6189-6193	NN	denotes	hair
T1982	6194-6199	NNS	denotes	cells
T1985	6199-6200	.	denotes	.
T1986	6200-6201	sentence	denotes
T8591	6211-6215	NN	denotes	Size
T8592	6216-6226	NNS	denotes	variations
T8593	6227-6229	IN	denotes	of
T8594	6230-6240	JJ	denotes	vestibular
T8595	6241-6248	NNS	denotes	ganglia
T8596	6249-6251	IN	denotes	in
T8597	6252-6259	NN	denotes	control
T8599	6260-6263	CC	denotes	and
T8600	6264-6270	JJ	denotes	mutant
T8598	6271-6282	NNS	denotes	littermates
T8601	6283-6290	VBN	denotes	labeled
T8602	6291-6295	IN	denotes	with
T8603	6296-6299	NN	denotes	DiI
T8604	6299-6300	.	denotes	.
T8605	6300-6434	sentence	denotes	In newborn animals, the vestibular ganglion shows a dramatic reduction in Brn3c null mutants (b) compared to control littermates (a).
T8606	6301-6303	IN	denotes	In
T8608	6304-6311	JJ	denotes	newborn
T8609	6312-6319	NNS	denotes	animals
T8610	6319-6321	,	denotes	,
T8611	6321-6324	DT	denotes	the
T8613	6325-6335	JJ	denotes	vestibular
T8612	6336-6344	NN	denotes	ganglion
T8607	6345-6350	VBZ	denotes	shows
T8614	6351-6352	DT	denotes	a
T8616	6353-6361	JJ	denotes	dramatic
T8615	6362-6371	NN	denotes	reduction
T8617	6372-6374	IN	denotes	in
T8618	6375-6380	NN	denotes	Brn3c
T8619	6381-6385	JJ	denotes	null
T8620	6386-6393	NNS	denotes	mutants
T8621	6394-6395	-LRB-	denotes	(
T8622	6395-6396	NN	denotes	b
T8623	6396-6397	-RRB-	denotes	)
T8624	6398-6406	VBN	denotes	compared
T8625	6407-6409	IN	denotes	to
T8626	6410-6417	NN	denotes	control
T8627	6418-6429	NNS	denotes	littermates
T8628	6430-6431	-LRB-	denotes	(
T8629	6431-6432	DT	denotes	a
T8630	6432-6433	-RRB-	denotes	)
T8631	6433-6434	.	denotes	.
T8632	6434-6901	sentence	denotes	Abbreviations for this and other figures: AC, anterior crista; ggl, ganglion; c, spiral capillary; Genic. ggl., geniculate ganglion; GER, greater epithelial ridge; HC, horizontal crista; HaC, vestibular hair cell; IHC, inner hair cell; iHC, immature hair cell; IGSB, intraganglionic spiral bundle; OHC, outer hair cell; PC, posterior crista; S, saccule; SG, spiral ganglion; TM, tectorial membrane; U, utricle; VCN, ventral cochlear nucleus; VG, vestibular ganglion.
T8633	6435-6448	NNS	denotes	Abbreviations
T8635	6449-6452	IN	denotes	for
T8636	6453-6457	DT	denotes	this
T8637	6458-6461	CC	denotes	and
T8638	6462-6467	JJ	denotes	other
T8639	6468-6475	NNS	denotes	figures
T8640	6475-6477	:	denotes	:
T8634	6477-6479	NN	denotes	AC
T8641	6479-6481	,	denotes	,
T8642	6481-6489	JJ	denotes	anterior
T8643	6490-6496	NN	denotes	crista
T8644	6496-6497	:	denotes	;
T8645	6498-6501	NN	denotes	ggl
T8646	6501-6503	,	denotes	,
T8647	6503-6511	NN	denotes	ganglion
T8648	6511-6512	:	denotes	;
T8649	6513-6514	NN	denotes	c
T8650	6514-6516	,	denotes	,
T8651	6516-6522	JJ	denotes	spiral
T8652	6523-6532	NN	denotes	capillary
T8653	6532-6533	:	denotes	;
T8654	6534-6540	NNP	denotes	Genic.
T8655	6541-6545	NNP	denotes	ggl.
T8656	6545-6547	,	denotes	,
T8657	6547-6557	JJ	denotes	geniculate
T8658	6558-6566	NN	denotes	ganglion
T8659	6566-6567	:	denotes	;
T8660	6568-6571	NN	denotes	GER
T8661	6571-6573	,	denotes	,
T8662	6573-6580	JJR	denotes	greater
T8664	6581-6591	JJ	denotes	epithelial
T8663	6592-6597	NN	denotes	ridge
T8665	6597-6598	:	denotes	;
T8666	6599-6601	NN	denotes	HC
T8667	6601-6603	,	denotes	,
T8668	6603-6613	JJ	denotes	horizontal
T8669	6614-6620	NN	denotes	crista
T8670	6620-6621	:	denotes	;
T8671	6622-6625	NN	denotes	HaC
T8672	6625-6627	,	denotes	,
T8673	6627-6637	JJ	denotes	vestibular
T8675	6638-6642	NN	denotes	hair
T8674	6643-6647	NN	denotes	cell
T8676	6647-6648	:	denotes	;
T8677	6649-6652	NN	denotes	IHC
T8678	6652-6654	,	denotes	,
T8679	6654-6659	JJ	denotes	inner
T8681	6660-6664	NN	denotes	hair
T8680	6665-6669	NN	denotes	cell
T8682	6669-6670	:	denotes	;
T8683	6671-6674	NN	denotes	iHC
T8684	6674-6676	,	denotes	,
T8685	6676-6684	JJ	denotes	immature
T8687	6685-6689	NN	denotes	hair
T8686	6690-6694	NN	denotes	cell
T8688	6694-6695	:	denotes	;
T8689	6696-6700	NN	denotes	IGSB
T8690	6700-6702	,	denotes	,
T8691	6702-6717	JJ	denotes	intraganglionic
T8693	6718-6724	JJ	denotes	spiral
T8692	6725-6731	NN	denotes	bundle
T8694	6731-6732	:	denotes	;
T8695	6733-6736	NN	denotes	OHC
T8696	6736-6738	,	denotes	,
T8697	6738-6743	JJ	denotes	outer
T8699	6744-6748	NN	denotes	hair
T8698	6749-6753	NN	denotes	cell
T8700	6753-6754	:	denotes	;
T8701	6755-6757	NN	denotes	PC
T8702	6757-6759	,	denotes	,
T8703	6759-6768	JJ	denotes	posterior
T8704	6769-6775	NN	denotes	crista
T8705	6775-6776	:	denotes	;
T8706	6777-6778	NN	denotes	S
T8707	6778-6780	,	denotes	,
T8708	6780-6787	NN	denotes	saccule
T8709	6787-6788	:	denotes	;
T8710	6789-6791	NN	denotes	SG
T8711	6791-6793	,	denotes	,
T8712	6793-6799	JJ	denotes	spiral
T8713	6800-6808	NN	denotes	ganglion
T8714	6808-6809	:	denotes	;
T8715	6810-6812	NN	denotes	TM
T8716	6812-6814	,	denotes	,
T8717	6814-6823	JJ	denotes	tectorial
T8718	6824-6832	NN	denotes	membrane
T8719	6832-6833	:	denotes	;
T8720	6834-6835	NN	denotes	U
T8721	6835-6837	,	denotes	,
T8722	6837-6844	NN	denotes	utricle
T8723	6844-6845	:	denotes	;
T8724	6846-6849	NN	denotes	VCN
T8725	6849-6851	,	denotes	,
T8726	6851-6858	JJ	denotes	ventral
T8728	6859-6867	JJ	denotes	cochlear
T8727	6868-6875	NN	denotes	nucleus
T8729	6875-6876	:	denotes	;
T8730	6877-6879	NN	denotes	VG
T8731	6879-6881	,	denotes	,
T8732	6881-6891	JJ	denotes	vestibular
T8733	6892-6900	NN	denotes	ganglion
T8734	6900-6901	.	denotes	.
T8735	6901-6924	sentence	denotes	Bar indicates 1000 μm.
T8736	6902-6905	NNP	denotes	Bar
T8737	6906-6915	VBZ	denotes	indicates
T8738	6916-6920	CD	denotes	1000
T8739	6921-6923	NNS	denotes	μm
T8740	6923-6924	.	denotes	.
T1988	6925-6926	NN	denotes	H
T1987	6925-6927	sentence	denotes	Ho
T1989	6926-6927	JJ	denotes	o
T1991	6927-6932	RB	denotes	wever
T1990	6927-7053	sentence	denotes	wever, the Brn3c null mutants show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia.
T1993	6932-6934	,	denotes	,
T1994	6934-6937	DT	denotes	the
T1996	6938-6943	NN	denotes	Brn3c
T1997	6944-6948	JJ	denotes	null
T1995	6949-6956	NNS	denotes	mutants
T1992	6957-6961	VBP	denotes	show
T1998	6962-6966	RB	denotes	only
T2000	6967-6968	DT	denotes	a
T2001	6969-6976	VBN	denotes	reduced
T1999	6977-6984	NN	denotes	density
T2002	6985-6987	IN	denotes	of
T2003	6988-6996	JJ	denotes	afferent
T2005	6997-7000	CC	denotes	and
T2006	7001-7009	JJ	denotes	efferent
T2004	7010-7016	NNS	denotes	fibers
T2007	7017-7019	IN	denotes	to
T2008	7020-7023	DT	denotes	all
T2010	7024-7034	JJ	denotes	vestibular
T2011	7035-7042	JJ	denotes	sensory
T2009	7043-7052	NNS	denotes	epithelia
T2012	7052-7053	.	denotes	.
T2013	7053-7208	sentence	denotes	There is no specific loss of all afferent and efferent innervation to the canal crista (Fig. 2a), a hallmark of both BDNF and trkB null mutations [13,15].
T2014	7054-7059	EX	denotes	There
T2015	7060-7062	VBZ	denotes	is
T2016	7063-7065	DT	denotes	no
T2018	7066-7074	JJ	denotes	specific
T2017	7075-7079	NN	denotes	loss
T2019	7080-7082	IN	denotes	of
T2020	7083-7086	DT	denotes	all
T2022	7087-7095	JJ	denotes	afferent
T2023	7096-7099	CC	denotes	and
T2024	7100-7108	JJ	denotes	efferent
T2021	7109-7120	NN	denotes	innervation
T2025	7121-7123	IN	denotes	to
T2026	7124-7127	DT	denotes	the
T2028	7128-7133	JJ	denotes	canal
T2027	7134-7140	NN	denotes	crista
T2029	7141-7142	-LRB-	denotes	(
T2031	7142-7146	NN	denotes	Fig.
T2030	7147-7149	NN	denotes	2a
T2032	7149-7150	-RRB-	denotes	)
T2033	7150-7152	,	denotes	,
T2034	7152-7153	DT	denotes	a
T2035	7154-7162	NN	denotes	hallmark
T2036	7163-7165	IN	denotes	of
T2037	7166-7170	CC	denotes	both
T2038	7171-7175	NN	denotes	BDNF
T2040	7176-7179	CC	denotes	and
T2041	7180-7184	NN	denotes	trkB
T2039	7185-7189	JJ	denotes	null
T2042	7190-7199	NNS	denotes	mutations
T2043	7200-7201	-LRB-	denotes	[
T2045	7201-7203	CD	denotes	13
T2046	7203-7204	,	denotes	,
T2044	7204-7206	CD	denotes	15
T2047	7206-7207	-RRB-	denotes	]
T2048	7207-7208	.	denotes	.
T2049	7208-7419	sentence	denotes	In fact, the reduction of fibers seems to be rather uniform throughout a given sensory epithelium with the crista innervation being qualitatively no more reduced than the innervation of the utricle and saccule.
T2050	7209-7211	IN	denotes	In
T2052	7212-7216	NN	denotes	fact
T2053	7216-7218	,	denotes	,
T2054	7218-7221	DT	denotes	the
T2055	7222-7231	NN	denotes	reduction
T2056	7232-7234	IN	denotes	of
T2057	7235-7241	NNS	denotes	fibers
T2051	7242-7247	VBZ	denotes	seems
T2058	7248-7250	TO	denotes	to
T2059	7251-7253	VB	denotes	be
T2060	7254-7260	RB	denotes	rather
T2061	7261-7268	JJ	denotes	uniform
T2062	7269-7279	IN	denotes	throughout
T2063	7280-7281	DT	denotes	a
T2065	7282-7287	VBN	denotes	given
T2066	7288-7295	JJ	denotes	sensory
T2064	7296-7306	NN	denotes	epithelium
T2067	7307-7311	IN	denotes	with
T2068	7312-7315	DT	denotes	the
T2070	7316-7322	NN	denotes	crista
T2069	7323-7334	NN	denotes	innervation
T2071	7335-7340	VBG	denotes	being
T2072	7341-7354	RB	denotes	qualitatively
T2073	7355-7357	DT	denotes	no
T2074	7358-7362	RBR	denotes	more
T2075	7363-7370	VBN	denotes	reduced
T2076	7371-7375	IN	denotes	than
T2077	7376-7379	DT	denotes	the
T2078	7380-7391	NN	denotes	innervation
T2079	7392-7394	IN	denotes	of
T2080	7395-7398	DT	denotes	the
T2081	7399-7406	NN	denotes	utricle
T2082	7407-7410	CC	denotes	and
T2083	7411-7418	NN	denotes	saccule
T2084	7418-7419	.	denotes	.
T2085	7419-7549	sentence	denotes	No loss in specific areas, comparable to that in BDNF null mutant mice, is apparent in the saccule or utricle of Brn3c null mice.
T2086	7420-7422	DT	denotes	No
T2087	7423-7427	NN	denotes	loss
T2089	7428-7430	IN	denotes	in
T2090	7431-7439	JJ	denotes	specific
T2091	7440-7445	NNS	denotes	areas
T2092	7445-7447	,	denotes	,
T2093	7447-7457	JJ	denotes	comparable
T2094	7458-7460	IN	denotes	to
T2095	7461-7465	DT	denotes	that
T2096	7466-7468	IN	denotes	in
T2097	7469-7473	NN	denotes	BDNF
T2098	7474-7478	JJ	denotes	null
T2100	7479-7485	JJ	denotes	mutant
T2099	7486-7490	NNS	denotes	mice
T2101	7490-7492	,	denotes	,
T2088	7492-7494	VBZ	denotes	is
T2102	7495-7503	JJ	denotes	apparent
T2103	7504-7506	IN	denotes	in
T2104	7507-7510	DT	denotes	the
T2105	7511-7518	NN	denotes	saccule
T2106	7519-7521	CC	denotes	or
T2107	7522-7529	NN	denotes	utricle
T2108	7530-7532	IN	denotes	of
T2109	7533-7538	NN	denotes	Brn3c
T2110	7539-7543	JJ	denotes	null
T2111	7544-7548	NNS	denotes	mice
T2112	7548-7549	.	denotes	.
T2113	7549-7650	sentence	denotes	Similar patterns of innervation are obtained using acteylated tubulin immunocytochemistry (Fig. 2b).
T2114	7550-7557	JJ	denotes	Similar
T2115	7558-7566	NNS	denotes	patterns
T2117	7567-7569	IN	denotes	of
T2118	7570-7581	NN	denotes	innervation
T2119	7582-7585	VBP	denotes	are
T2116	7586-7594	VBN	denotes	obtained
T2120	7595-7600	VBG	denotes	using
T2121	7601-7611	VBN	denotes	acteylated
T2122	7612-7619	NN	denotes	tubulin
T2123	7620-7639	NN	denotes	immunocytochemistry
T2124	7640-7641	-LRB-	denotes	(
T2126	7641-7645	NN	denotes	Fig.
T2125	7646-7648	NN	denotes	2b
T2127	7648-7649	-RRB-	denotes	)
T2128	7649-7650	.	denotes	.
T2129	7650-7651	sentence	denotes
T8782	7661-7672	NN	denotes	Innervation
T8784	7673-7675	IN	denotes	of
T8785	7676-7681	NN	denotes	Brn3c
T8787	7682-7686	JJ	denotes	null
T8789	7687-7690	CC	denotes	and
T8788	7691-7698	NN	denotes	control
T8786	7699-7703	NNS	denotes	ears
T8790	7704-7707	VBP	denotes	are
T8783	7708-7713	VBN	denotes	shown
T8791	7714-7717	IN	denotes	for
T8792	7718-7725	JJ	denotes	newborn
T8793	7726-7730	NNS	denotes	mice
T8794	7730-7731	.	denotes	.
T8795	7731-7873	sentence	denotes	There is no specific loss of fibers to any vestibular endorgan, as visualized by DiI labeling (a) or acetylated tubulin immunoreactivity (b).
T8796	7732-7737	EX	denotes	There
T8797	7738-7740	VBZ	denotes	is
T8798	7741-7743	DT	denotes	no
T8800	7744-7752	JJ	denotes	specific
T8799	7753-7757	NN	denotes	loss
T8801	7758-7760	IN	denotes	of
T8802	7761-7767	NNS	denotes	fibers
T8803	7768-7770	IN	denotes	to
T8804	7771-7774	DT	denotes	any
T8806	7775-7785	JJ	denotes	vestibular
T8805	7786-7794	NN	denotes	endorgan
T8807	7794-7796	,	denotes	,
T8808	7796-7798	IN	denotes	as
T8809	7799-7809	VBN	denotes	visualized
T8810	7810-7812	IN	denotes	by
T8811	7813-7816	NN	denotes	DiI
T8812	7817-7825	NN	denotes	labeling
T8813	7826-7827	-LRB-	denotes	(
T8814	7827-7828	DT	denotes	a
T8815	7828-7829	-RRB-	denotes	)
T8816	7830-7832	CC	denotes	or
T8817	7833-7843	VBN	denotes	acetylated
T8818	7844-7851	NN	denotes	tubulin
T8819	7852-7868	NN	denotes	immunoreactivity
T8820	7869-7870	-LRB-	denotes	(
T8821	7870-7871	NN	denotes	b
T8822	7871-7872	-RRB-	denotes	)
T8823	7872-7873	.	denotes	.
T8824	7873-8034	sentence	denotes	No major differences in pattern of projection through radial fibers are found in the cochlea of Brn3c null mutants (d,f) as compared to control littermates (c).
T8825	7874-7876	DT	denotes	No
T8827	7877-7882	JJ	denotes	major
T8826	7883-7894	NNS	denotes	differences
T8829	7895-7897	IN	denotes	in
T8830	7898-7905	NN	denotes	pattern
T8831	7906-7908	IN	denotes	of
T8832	7909-7919	NN	denotes	projection
T8833	7920-7927	IN	denotes	through
T8834	7928-7934	NN	denotes	radial
T8835	7935-7941	NNS	denotes	fibers
T8836	7942-7945	VBP	denotes	are
T8828	7946-7951	VBN	denotes	found
T8837	7952-7954	IN	denotes	in
T8838	7955-7958	DT	denotes	the
T8839	7959-7966	NN	denotes	cochlea
T8840	7967-7969	IN	denotes	of
T8841	7970-7975	NN	denotes	Brn3c
T8843	7976-7980	JJ	denotes	null
T8842	7981-7988	NNS	denotes	mutants
T8844	7989-7990	-LRB-	denotes	(
T8846	7990-7991	NN	denotes	d
T8847	7991-7992	,	denotes	,
T8845	7992-7993	NN	denotes	f
T8848	7993-7994	-RRB-	denotes	)
T8849	7995-7997	IN	denotes	as
T8850	7998-8006	VBN	denotes	compared
T8851	8007-8009	IN	denotes	to
T8852	8010-8017	NN	denotes	control
T8853	8018-8029	NNS	denotes	littermates
T8854	8030-8031	-LRB-	denotes	(
T8855	8031-8032	NN	denotes	c
T8856	8032-8033	-RRB-	denotes	)
T8857	8033-8034	.	denotes	.
T8858	8034-8117	sentence	denotes	Note, however, the lack of orderly fiber outgrowth to the outer hair cells (c, d).
T8859	8035-8039	VB	denotes	Note
T8860	8039-8041	,	denotes	,
T8861	8041-8048	RB	denotes	however
T8862	8048-8050	,	denotes	,
T8863	8050-8053	DT	denotes	the
T8864	8054-8058	NN	denotes	lack
T8865	8059-8061	IN	denotes	of
T8866	8062-8069	JJ	denotes	orderly
T8868	8070-8075	NN	denotes	fiber
T8867	8076-8085	NN	denotes	outgrowth
T8869	8086-8088	IN	denotes	to
T8870	8089-8092	DT	denotes	the
T8872	8093-8098	JJ	denotes	outer
T8873	8099-8103	NN	denotes	hair
T8871	8104-8109	NNS	denotes	cells
T8874	8110-8111	-LRB-	denotes	(
T8876	8111-8112	NN	denotes	c
T8877	8112-8114	,	denotes	,
T8875	8114-8115	NN	denotes	d
T8878	8115-8116	-RRB-	denotes	)
T8879	8116-8117	.	denotes	.
T8880	8117-8260	sentence	denotes	Efferent fibers to the ear show a well developed intraganglionic spiral bundle (IGSB) with no detectable differences compared to controls (e).
T8881	8118-8126	JJ	denotes	Efferent
T8882	8127-8133	NNS	denotes	fibers
T8884	8134-8136	IN	denotes	to
T8885	8137-8140	DT	denotes	the
T8886	8141-8144	NN	denotes	ear
T8883	8145-8149	VBP	denotes	show
T8887	8150-8151	DT	denotes	a
T8889	8152-8156	RB	denotes	well
T8890	8157-8166	VBN	denotes	developed
T8891	8167-8182	JJ	denotes	intraganglionic
T8892	8183-8189	JJ	denotes	spiral
T8888	8190-8196	NN	denotes	bundle
T8893	8197-8198	-LRB-	denotes	(
T8894	8198-8202	NN	denotes	IGSB
T8895	8202-8203	-RRB-	denotes	)
T8896	8204-8208	IN	denotes	with
T8897	8209-8211	DT	denotes	no
T8899	8212-8222	JJ	denotes	detectable
T8898	8223-8234	NNS	denotes	differences
T8900	8235-8243	VBN	denotes	compared
T8901	8244-8246	IN	denotes	to
T8902	8247-8255	NNS	denotes	controls
T8903	8256-8257	-LRB-	denotes	(
T8904	8257-8258	NN	denotes	e
T8905	8258-8259	-RRB-	denotes	)
T8906	8259-8260	.	denotes	.
T8907	8260-8282	sentence	denotes	Bar indicates 100 μm.
T8908	8261-8264	NNP	denotes	Bar
T8909	8265-8274	VBZ	denotes	indicates
T8910	8275-8278	CD	denotes	100
T8911	8279-8281	NNS	denotes	μm
T8912	8281-8282	.	denotes	.
T2131	8283-8293	JJ	denotes	Consistent
T2130	8283-8498	sentence	denotes	Consistent with the finding of Xiang et al. [3] of only a 29% loss of spiral sensory neurons at P4, our data show little difference in the pattern of innervation of the cochlea in P0 Brn3c null mutants (Fig. 2c,2d).
T2133	8294-8298	IN	denotes	with
T2134	8299-8302	DT	denotes	the
T2135	8303-8310	NN	denotes	finding
T2136	8311-8313	IN	denotes	of
T2137	8314-8319	NNP	denotes	Xiang
T2138	8320-8322	FW	denotes	et
T2139	8323-8326	FW	denotes	al.
T2140	8327-8328	-LRB-	denotes	[
T2141	8328-8329	CD	denotes	3
T2142	8329-8330	-RRB-	denotes	]
T2143	8331-8333	IN	denotes	of
T2144	8334-8338	RB	denotes	only
T2146	8339-8340	DT	denotes	a
T2147	8341-8343	CD	denotes	29
T2148	8343-8344	NN	denotes	%
T2145	8345-8349	NN	denotes	loss
T2149	8350-8352	IN	denotes	of
T2150	8353-8359	JJ	denotes	spiral
T2152	8360-8367	JJ	denotes	sensory
T2151	8368-8375	NNS	denotes	neurons
T2153	8376-8378	IN	denotes	at
T2154	8379-8381	NN	denotes	P4
T2155	8381-8383	,	denotes	,
T2156	8383-8386	PRP$	denotes	our
T2157	8387-8391	NNS	denotes	data
T2132	8392-8396	VBP	denotes	show
T2158	8397-8403	JJ	denotes	little
T2159	8404-8414	NN	denotes	difference
T2160	8415-8417	IN	denotes	in
T2161	8418-8421	DT	denotes	the
T2162	8422-8429	NN	denotes	pattern
T2163	8430-8432	IN	denotes	of
T2164	8433-8444	NN	denotes	innervation
T2165	8445-8447	IN	denotes	of
T2166	8448-8451	DT	denotes	the
T2167	8452-8459	NN	denotes	cochlea
T2168	8460-8462	IN	denotes	in
T2169	8463-8465	NN	denotes	P0
T2171	8466-8471	NN	denotes	Brn3c
T2172	8472-8476	JJ	denotes	null
T2170	8477-8484	NNS	denotes	mutants
T2173	8485-8486	-LRB-	denotes	(
T2175	8486-8490	NNP	denotes	Fig.
T2176	8491-8493	NN	denotes	2c
T2177	8493-8494	,	denotes	,
T2174	8494-8496	NN	denotes	2d
T2178	8496-8497	-RRB-	denotes	)
T2179	8497-8498	.	denotes	.
T2180	8498-8635	sentence	denotes	No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [6,9,14].
T2181	8499-8501	DT	denotes	No
T2183	8502-8511	JJ	denotes	selective
T2182	8512-8516	NN	denotes	loss
T2185	8517-8519	IN	denotes	of
T2186	8520-8526	JJ	denotes	spiral
T2187	8527-8534	NNS	denotes	neurons
T2188	8535-8537	VBZ	denotes	is
T2184	8538-8546	VBN	denotes	observed
T2189	8547-8549	IN	denotes	in
T2190	8550-8555	NN	denotes	Brn3c
T2192	8556-8560	JJ	denotes	null
T2191	8561-8568	NNS	denotes	mutants
T2193	8569-8571	IN	denotes	in
T2194	8572-8575	DT	denotes	the
T2196	8576-8581	JJ	denotes	basal
T2195	8582-8586	NN	denotes	turn
T2197	8586-8588	,	denotes	,
T2198	8588-8589	DT	denotes	a
T2199	8590-8597	NN	denotes	feature
T2200	8598-8600	IN	denotes	of
T2201	8601-8607	CC	denotes	either
T2202	8608-8610	NN	denotes	NT
T2204	8610-8611	HYPH	denotes	-
T2205	8611-8612	CD	denotes	3
T2206	8613-8615	CC	denotes	or
T2207	8616-8620	NN	denotes	trkC
T2203	8621-8625	NN	denotes	loss
T2208	8626-8627	-LRB-	denotes	[
T2210	8627-8628	CD	denotes	6
T2211	8628-8629	,	denotes	,
T2212	8629-8630	CD	denotes	9
T2213	8630-8631	,	denotes	,
T2209	8631-8633	CD	denotes	14
T2214	8633-8634	-RRB-	denotes	]
T2215	8634-8635	.	denotes	.
T2216	8635-8855	sentence	denotes	Likewise, the innervation of the apex (Fig. 2f) shows no detectable abnormality in overall pattern of innervation compared to control animals (data not shown), an indication that BDNF could be expressed in the apex [6].
T2217	8636-8644	RB	denotes	Likewise
T2219	8644-8646	,	denotes	,
T2220	8646-8649	DT	denotes	the
T2221	8650-8661	NN	denotes	innervation
T2222	8662-8664	IN	denotes	of
T2223	8665-8668	DT	denotes	the
T2224	8669-8673	NN	denotes	apex
T2225	8674-8675	-LRB-	denotes	(
T2227	8675-8679	NN	denotes	Fig.
T2226	8680-8682	NN	denotes	2f
T2228	8682-8683	-RRB-	denotes	)
T2218	8684-8689	VBZ	denotes	shows
T2229	8690-8692	DT	denotes	no
T2231	8693-8703	JJ	denotes	detectable
T2230	8704-8715	NN	denotes	abnormality
T2232	8716-8718	IN	denotes	in
T2233	8719-8726	JJ	denotes	overall
T2234	8727-8734	NN	denotes	pattern
T2235	8735-8737	IN	denotes	of
T2236	8738-8749	NN	denotes	innervation
T2237	8750-8758	VBN	denotes	compared
T2238	8759-8761	IN	denotes	to
T2239	8762-8769	NN	denotes	control
T2240	8770-8777	NNS	denotes	animals
T2241	8778-8779	-LRB-	denotes	(
T2243	8779-8783	NNS	denotes	data
T2244	8784-8787	RB	denotes	not
T2242	8788-8793	VBN	denotes	shown
T2245	8793-8794	-RRB-	denotes	)
T2246	8794-8796	,	denotes	,
T2247	8796-8798	DT	denotes	an
T2248	8799-8809	NN	denotes	indication
T2249	8810-8814	IN	denotes	that
T2251	8815-8819	NN	denotes	BDNF
T2252	8820-8825	MD	denotes	could
T2253	8826-8828	VB	denotes	be
T2250	8829-8838	VBN	denotes	expressed
T2254	8839-8841	IN	denotes	in
T2255	8842-8845	DT	denotes	the
T2256	8846-8850	NN	denotes	apex
T2257	8851-8852	-LRB-	denotes	[
T2258	8852-8853	CD	denotes	6
T2259	8853-8854	-RRB-	denotes	]
T2260	8854-8855	.	denotes	.
T2261	8855-9050	sentence	denotes	In addition, the pattern of efferent innervation shows no deviation from normal either (Fig. 2e), whereas they show the same pattern of loss as afferent fibers in neurotrophin null mutants [16].
T2262	8856-8858	IN	denotes	In
T2264	8859-8867	NN	denotes	addition
T2265	8867-8869	,	denotes	,
T2266	8869-8872	DT	denotes	the
T2267	8873-8880	NN	denotes	pattern
T2268	8881-8883	IN	denotes	of
T2269	8884-8892	JJ	denotes	efferent
T2270	8893-8904	NN	denotes	innervation
T2263	8905-8910	VBZ	denotes	shows
T2271	8911-8913	DT	denotes	no
T2272	8914-8923	NN	denotes	deviation
T2273	8924-8928	IN	denotes	from
T2274	8929-8935	JJ	denotes	normal
T2275	8936-8942	RB	denotes	either
T2276	8943-8944	-LRB-	denotes	(
T2278	8944-8948	NNP	denotes	Fig.
T2277	8949-8951	NNP	denotes	2e
T2279	8951-8952	-RRB-	denotes	)
T2280	8952-8954	,	denotes	,
T2281	8954-8961	IN	denotes	whereas
T2283	8962-8966	PRP	denotes	they
T2282	8967-8971	VBP	denotes	show
T2284	8972-8975	DT	denotes	the
T2286	8976-8980	JJ	denotes	same
T2285	8981-8988	NN	denotes	pattern
T2287	8989-8991	IN	denotes	of
T2288	8992-8996	NN	denotes	loss
T2289	8997-8999	IN	denotes	as
T2290	9000-9008	JJ	denotes	afferent
T2291	9009-9015	NNS	denotes	fibers
T2292	9016-9018	IN	denotes	in
T2293	9019-9031	NN	denotes	neurotrophin
T2295	9032-9036	JJ	denotes	null
T2294	9037-9044	NNS	denotes	mutants
T2296	9045-9046	-LRB-	denotes	[
T2297	9046-9048	CD	denotes	16
T2298	9048-9049	-RRB-	denotes	]
T2299	9049-9050	.	denotes	.
T2300	9050-9201	sentence	denotes	These data suggest that the spiral sensory neurons develop qualitatively normal at least until P0 and therefore allow normal pathfinding of efferents.
T2301	9051-9056	DT	denotes	These
T2302	9057-9061	NNS	denotes	data
T2303	9062-9069	VBP	denotes	suggest
T2304	9070-9074	IN	denotes	that
T2306	9075-9078	DT	denotes	the
T2308	9079-9085	JJ	denotes	spiral
T2309	9086-9093	JJ	denotes	sensory
T2307	9094-9101	NNS	denotes	neurons
T2305	9102-9109	VBP	denotes	develop
T2310	9110-9123	RB	denotes	qualitatively
T2311	9124-9130	JJ	denotes	normal
T2312	9131-9133	RB	denotes	at
T2313	9134-9139	RBS	denotes	least
T2314	9140-9145	IN	denotes	until
T2315	9146-9148	NN	denotes	P0
T2316	9149-9152	CC	denotes	and
T2317	9153-9162	RB	denotes	therefore
T2318	9163-9168	VBP	denotes	allow
T2319	9169-9175	JJ	denotes	normal
T2320	9176-9187	NN	denotes	pathfinding
T2321	9188-9190	IN	denotes	of
T2322	9191-9200	NNS	denotes	efferents
T2323	9200-9201	.	denotes	.
T2324	9201-9327	sentence	denotes	Most interestingly, there is no increase in radial fiber spacing in the apex, a specific problem of BDNF null mutants [6,13].
T2325	9202-9206	RBS	denotes	Most
T2326	9207-9220	RB	denotes	interestingly
T2328	9220-9222	,	denotes	,
T2329	9222-9227	EX	denotes	there
T2327	9228-9230	VBZ	denotes	is
T2330	9231-9233	DT	denotes	no
T2331	9234-9242	NN	denotes	increase
T2332	9243-9245	IN	denotes	in
T2333	9246-9252	JJ	denotes	radial
T2334	9253-9258	NN	denotes	fiber
T2335	9259-9266	NN	denotes	spacing
T2336	9267-9269	IN	denotes	in
T2337	9270-9273	DT	denotes	the
T2338	9274-9278	NN	denotes	apex
T2339	9278-9280	,	denotes	,
T2340	9280-9281	DT	denotes	a
T2342	9282-9290	JJ	denotes	specific
T2341	9291-9298	NN	denotes	problem
T2343	9299-9301	IN	denotes	of
T2344	9302-9306	NN	denotes	BDNF
T2346	9307-9311	JJ	denotes	null
T2345	9312-9319	NNS	denotes	mutants
T2347	9320-9321	-LRB-	denotes	[
T2349	9321-9322	CD	denotes	6
T2350	9322-9323	,	denotes	,
T2348	9323-9325	CD	denotes	13
T2351	9325-9326	-RRB-	denotes	]
T2352	9326-9327	.	denotes	.
T2353	9327-9427	sentence	denotes	However, there is one qualitative difference not recognized in any single neurotrophin null mutant.
T2354	9328-9335	RB	denotes	However
T2356	9335-9337	,	denotes	,
T2357	9337-9342	EX	denotes	there
T2355	9343-9345	VBZ	denotes	is
T2358	9346-9349	CD	denotes	one
T2360	9350-9361	JJ	denotes	qualitative
T2359	9362-9372	NN	denotes	difference
T2361	9373-9376	RB	denotes	not
T2362	9377-9387	VBN	denotes	recognized
T2363	9388-9390	IN	denotes	in
T2364	9391-9394	DT	denotes	any
T2366	9395-9401	JJ	denotes	single
T2367	9402-9414	NN	denotes	neurotrophin
T2368	9415-9419	JJ	denotes	null
T2365	9420-9426	NN	denotes	mutant
T2369	9426-9427	.	denotes	.
T2370	9427-9794	sentence	denotes	Afferents reach all three rows of outer hair cells in the basal turn of control wildtype littermates (Fig. 2c), but both afferent and efferent outgrowth is disorganized to outer hair cells in Brn3c null mutants (Fig. 2d) and does not show any clear organization into three distinct longitudinal fiber bundles paralleling the three rows in the outer hair cell region.
T2371	9428-9437	NNS	denotes	Afferents
T2372	9438-9443	VBP	denotes	reach
T2373	9444-9447	DT	denotes	all
T2375	9448-9453	CD	denotes	three
T2374	9454-9458	NNS	denotes	rows
T2376	9459-9461	IN	denotes	of
T2377	9462-9467	JJ	denotes	outer
T2379	9468-9472	NN	denotes	hair
T2378	9473-9478	NNS	denotes	cells
T2380	9479-9481	IN	denotes	in
T2381	9482-9485	DT	denotes	the
T2383	9486-9491	JJ	denotes	basal
T2382	9492-9496	NN	denotes	turn
T2384	9497-9499	IN	denotes	of
T2385	9500-9507	NN	denotes	control
T2387	9508-9516	JJ	denotes	wildtype
T2386	9517-9528	NNS	denotes	littermates
T2388	9529-9530	-LRB-	denotes	(
T2390	9530-9534	NN	denotes	Fig.
T2389	9535-9537	NN	denotes	2c
T2391	9537-9538	-RRB-	denotes	)
T2392	9538-9540	,	denotes	,
T2393	9540-9543	CC	denotes	but
T2394	9544-9548	CC	denotes	both
T2395	9549-9557	JJ	denotes	afferent
T2397	9558-9561	CC	denotes	and
T2398	9562-9570	JJ	denotes	efferent
T2396	9571-9580	NN	denotes	outgrowth
T2399	9581-9583	VBZ	denotes	is
T2400	9584-9596	JJ	denotes	disorganized
T2401	9597-9599	IN	denotes	to
T2402	9600-9605	JJ	denotes	outer
T2404	9606-9610	NN	denotes	hair
T2403	9611-9616	NNS	denotes	cells
T2405	9617-9619	IN	denotes	in
T2406	9620-9625	NN	denotes	Brn3c
T2407	9626-9630	JJ	denotes	null
T2408	9631-9638	NNS	denotes	mutants
T2409	9639-9640	-LRB-	denotes	(
T2411	9640-9644	NNP	denotes	Fig.
T2410	9645-9647	NNP	denotes	2d
T2412	9647-9648	-RRB-	denotes	)
T2413	9649-9652	CC	denotes	and
T2414	9653-9657	VBZ	denotes	does
T2416	9658-9661	RB	denotes	not
T2415	9662-9666	VB	denotes	show
T2417	9667-9670	DT	denotes	any
T2419	9671-9676	JJ	denotes	clear
T2418	9677-9689	NN	denotes	organization
T2420	9690-9694	IN	denotes	into
T2421	9695-9700	CD	denotes	three
T2423	9701-9709	JJ	denotes	distinct
T2424	9710-9722	JJ	denotes	longitudinal
T2425	9723-9728	NN	denotes	fiber
T2422	9729-9736	NNS	denotes	bundles
T2426	9737-9748	VBG	denotes	paralleling
T2427	9749-9752	DT	denotes	the
T2429	9753-9758	CD	denotes	three
T2428	9759-9763	NNS	denotes	rows
T2430	9764-9766	IN	denotes	in
T2431	9767-9770	DT	denotes	the
T2433	9771-9776	JJ	denotes	outer
T2434	9777-9781	NN	denotes	hair
T2435	9782-9786	NN	denotes	cell
T2432	9787-9793	NN	denotes	region
T2436	9793-9794	.	denotes	.
T2437	9794-9909	sentence	denotes	These data suggest that fiber organization in the outer hair cell region is partly disrupted in Brn3c null mutant.
T2438	9795-9800	DT	denotes	These
T2439	9801-9805	NNS	denotes	data
T2440	9806-9813	VBP	denotes	suggest
T2441	9814-9818	IN	denotes	that
T2443	9819-9824	NN	denotes	fiber
T2444	9825-9837	NN	denotes	organization
T2445	9838-9840	IN	denotes	in
T2446	9841-9844	DT	denotes	the
T2448	9845-9850	JJ	denotes	outer
T2449	9851-9855	NN	denotes	hair
T2450	9856-9860	NN	denotes	cell
T2447	9861-9867	NN	denotes	region
T2451	9868-9870	VBZ	denotes	is
T2452	9871-9877	RB	denotes	partly
T2442	9878-9887	VBN	denotes	disrupted
T2453	9888-9890	IN	denotes	in
T2454	9891-9896	NN	denotes	Brn3c
T2455	9897-9901	JJ	denotes	null
T2456	9902-9908	NN	denotes	mutant
T2457	9908-9909	.	denotes	.
T2770	9930-9932	IN	denotes	at
T2771	9933-9935	NN	denotes	P7
T2772	9935-9936	HYPH	denotes	/
T2773	9936-9937	CD	denotes	8
T2774	9937-10004	sentence	denotes	Reduction of vestibular innervation is more pronounced than at P0.
T2775	9938-9947	NN	denotes	Reduction
T2777	9948-9950	IN	denotes	of
T2778	9951-9961	JJ	denotes	vestibular
T2779	9962-9973	NN	denotes	innervation
T2776	9974-9976	VBZ	denotes	is
T2780	9977-9981	RBR	denotes	more
T2781	9982-9992	JJ	denotes	pronounced
T2782	9993-9997	IN	denotes	than
T2783	9998-10000	IN	denotes	at
T2784	10001-10003	NN	denotes	P0
T2785	10003-10004	.	denotes	.
T2786	10004-10136	sentence	denotes	Loss of afferents and, even more clearly of efferents, is most pronounced in the utricle (Fig. 3a,3b) and saccule (data not shown).
T2787	10005-10009	NN	denotes	Loss
T2789	10010-10012	IN	denotes	of
T2790	10013-10022	NNS	denotes	afferents
T2791	10023-10026	CC	denotes	and
T2792	10026-10028	,	denotes	,
T2793	10028-10032	RB	denotes	even
T2794	10033-10037	RBR	denotes	more
T2795	10038-10045	RB	denotes	clearly
T2796	10046-10048	IN	denotes	of
T2797	10049-10058	NNS	denotes	efferents
T2798	10058-10060	,	denotes	,
T2788	10060-10062	VBZ	denotes	is
T2799	10063-10067	RBS	denotes	most
T2800	10068-10078	JJ	denotes	pronounced
T2801	10079-10081	IN	denotes	in
T2802	10082-10085	DT	denotes	the
T2803	10086-10093	NN	denotes	utricle
T2804	10094-10095	-LRB-	denotes	(
T2806	10095-10099	NN	denotes	Fig.
T2807	10100-10102	NN	denotes	3a
T2808	10102-10103	,	denotes	,
T2805	10103-10105	NN	denotes	3b
T2809	10105-10106	-RRB-	denotes	)
T2810	10107-10110	CC	denotes	and
T2811	10111-10118	NN	denotes	saccule
T2812	10119-10120	-LRB-	denotes	(
T2814	10120-10124	NNS	denotes	data
T2815	10125-10128	RB	denotes	not
T2813	10129-10134	VBN	denotes	shown
T2816	10134-10135	-RRB-	denotes	)
T2817	10135-10136	.	denotes	.
T2818	10136-10230	sentence	denotes	In contrast, the innervation to the canal cristae, while reduced, has changed little from P0.
T2819	10137-10139	IN	denotes	In
T2821	10140-10148	NN	denotes	contrast
T2822	10148-10150	,	denotes	,
T2823	10150-10153	DT	denotes	the
T2824	10154-10165	NN	denotes	innervation
T2825	10166-10168	IN	denotes	to
T2826	10169-10172	DT	denotes	the
T2828	10173-10178	JJ	denotes	canal
T2827	10179-10186	NNS	denotes	cristae
T2829	10186-10188	,	denotes	,
T2830	10188-10193	IN	denotes	while
T2831	10194-10201	VBN	denotes	reduced
T2832	10201-10203	,	denotes	,
T2833	10203-10206	VBZ	denotes	has
T2820	10207-10214	VBN	denotes	changed
T2834	10215-10221	RB	denotes	little
T2835	10222-10226	IN	denotes	from
T2836	10227-10229	NN	denotes	P0
T2837	10229-10230	.	denotes	.
T2838	10230-10346	sentence	denotes	In particular the horizontal canal receives a rather dense afferent and efferent innervation in Brn3c null mutants.
T2839	10231-10233	IN	denotes	In
T2841	10234-10244	JJ	denotes	particular
T2842	10245-10248	DT	denotes	the
T2844	10249-10259	JJ	denotes	horizontal
T2843	10260-10265	NN	denotes	canal
T2840	10266-10274	VBZ	denotes	receives
T2845	10275-10276	DT	denotes	a
T2847	10277-10283	RB	denotes	rather
T2848	10284-10289	JJ	denotes	dense
T2849	10290-10298	JJ	denotes	afferent
T2850	10299-10302	CC	denotes	and
T2851	10303-10311	JJ	denotes	efferent
T2846	10312-10323	NN	denotes	innervation
T2852	10324-10326	IN	denotes	in
T2853	10327-10332	NN	denotes	Brn3c
T2855	10333-10337	JJ	denotes	null
T2854	10338-10345	NNS	denotes	mutants
T2856	10345-10346	.	denotes	.
T2857	10346-10347	sentence	denotes
T8959	10357-10366	NN	denotes	Reduction
T8961	10367-10369	IN	denotes	of
T8962	10370-10381	NN	denotes	innervation
T8963	10382-10384	IN	denotes	of
T8964	10385-10388	DT	denotes	the
T8965	10389-10392	NN	denotes	ear
T8966	10393-10395	VBZ	denotes	is
T8960	10396-10401	VBN	denotes	shown
T8967	10402-10404	IN	denotes	in
T8968	10405-10406	JJ	denotes	8
T8970	10406-10407	HYPH	denotes	-
T8969	10407-10410	JJ	denotes	day
T8971	10411-10414	JJ	denotes	old
T8972	10415-10419	NNS	denotes	mice
T8973	10419-10420	.	denotes	.
T8974	10420-10634	sentence	denotes	While all vestibular sensory epithelia retain some afferent (a) and efferent (b) innervation, there is a more pronounced reduction, in particular of efferent fibers, to the utricle (a,b) as compared to the canals.
T8975	10421-10426	IN	denotes	While
T8977	10427-10430	DT	denotes	all
T8979	10431-10441	JJ	denotes	vestibular
T8980	10442-10449	JJ	denotes	sensory
T8978	10450-10459	NNS	denotes	epithelia
T8976	10460-10466	VBP	denotes	retain
T8982	10467-10471	DT	denotes	some
T8984	10472-10480	JJ	denotes	afferent
T8985	10481-10482	-LRB-	denotes	(
T8986	10482-10483	NN	denotes	a
T8987	10483-10484	-RRB-	denotes	)
T8988	10485-10488	CC	denotes	and
T8989	10489-10497	JJ	denotes	efferent
T8990	10498-10499	-LRB-	denotes	(
T8991	10499-10500	NN	denotes	b
T8992	10500-10501	-RRB-	denotes	)
T8983	10502-10513	NN	denotes	innervation
T8993	10513-10515	,	denotes	,
T8994	10515-10520	EX	denotes	there
T8981	10521-10523	VBZ	denotes	is
T8995	10524-10525	DT	denotes	a
T8997	10526-10530	RBR	denotes	more
T8998	10531-10541	JJ	denotes	pronounced
T8996	10542-10551	NN	denotes	reduction
T8999	10551-10553	,	denotes	,
T9000	10553-10555	IN	denotes	in
T9002	10556-10566	JJ	denotes	particular
T9001	10567-10569	IN	denotes	of
T9003	10570-10578	JJ	denotes	efferent
T9004	10579-10585	NNS	denotes	fibers
T9005	10585-10587	,	denotes	,
T9006	10587-10589	IN	denotes	to
T9007	10590-10593	DT	denotes	the
T9008	10594-10601	NN	denotes	utricle
T9009	10602-10603	-LRB-	denotes	(
T9011	10603-10604	NN	denotes	a
T9012	10604-10605	,	denotes	,
T9010	10605-10606	NN	denotes	b
T9013	10606-10607	-RRB-	denotes	)
T9014	10608-10610	IN	denotes	as
T9015	10611-10619	VBN	denotes	compared
T9016	10620-10622	IN	denotes	to
T9017	10623-10626	DT	denotes	the
T9018	10627-10633	NNS	denotes	canals
T9019	10633-10634	.	denotes	.
T9020	10634-10733	sentence	denotes	In the cochlea there is an increased spacing between radial fiber bundles in the basal turn (c,e).
T9021	10635-10637	IN	denotes	In
T9023	10638-10641	DT	denotes	the
T9024	10642-10649	NN	denotes	cochlea
T9025	10650-10655	EX	denotes	there
T9022	10656-10658	VBZ	denotes	is
T9026	10659-10661	DT	denotes	an
T9028	10662-10671	VBN	denotes	increased
T9027	10672-10679	NN	denotes	spacing
T9029	10680-10687	IN	denotes	between
T9030	10688-10694	JJ	denotes	radial
T9032	10695-10700	NN	denotes	fiber
T9031	10701-10708	NNS	denotes	bundles
T9033	10709-10711	IN	denotes	in
T9034	10712-10715	DT	denotes	the
T9036	10716-10721	JJ	denotes	basal
T9035	10722-10726	NN	denotes	turn
T9037	10727-10728	-LRB-	denotes	(
T9039	10728-10729	NN	denotes	c
T9040	10729-10730	,	denotes	,
T9038	10730-10731	NN	denotes	e
T9041	10731-10732	-RRB-	denotes	)
T9042	10732-10733	.	denotes	.
T9043	10733-10847	sentence	denotes	No afferents can be traced to the three outer spiral bundles along outer hair cells of mutant littermates (c, e).
T9044	10734-10736	DT	denotes	No
T9045	10737-10746	NNS	denotes	afferents
T9047	10747-10750	MD	denotes	can
T9048	10751-10753	VB	denotes	be
T9046	10754-10760	VBN	denotes	traced
T9049	10761-10763	IN	denotes	to
T9050	10764-10767	DT	denotes	the
T9052	10768-10773	CD	denotes	three
T9053	10774-10779	JJ	denotes	outer
T9054	10780-10786	JJ	denotes	spiral
T9051	10787-10794	NNS	denotes	bundles
T9055	10795-10800	IN	denotes	along
T9056	10801-10806	JJ	denotes	outer
T9058	10807-10811	NN	denotes	hair
T9057	10812-10817	NNS	denotes	cells
T9059	10818-10820	IN	denotes	of
T9060	10821-10827	JJ	denotes	mutant
T9061	10828-10839	NNS	denotes	littermates
T9062	10840-10841	-LRB-	denotes	(
T9064	10841-10842	NN	denotes	c
T9065	10842-10844	,	denotes	,
T9063	10844-10845	NN	denotes	e
T9066	10845-10846	-RRB-	denotes	)
T9067	10846-10847	.	denotes	.
T9068	10847-11035	sentence	denotes	The apex shows little change, except for the absence of fibers to the area of outer hair cells and the formation of inner spiral bundles passing along the few immature hair cells (d,f,g).
T9069	10848-10851	DT	denotes	The
T9070	10852-10856	NN	denotes	apex
T9071	10857-10862	VBZ	denotes	shows
T9072	10863-10869	JJ	denotes	little
T9073	10870-10876	NN	denotes	change
T9074	10876-10878	,	denotes	,
T9075	10878-10884	IN	denotes	except
T9076	10885-10888	IN	denotes	for
T9077	10889-10892	DT	denotes	the
T9078	10893-10900	NN	denotes	absence
T9079	10901-10903	IN	denotes	of
T9080	10904-10910	NNS	denotes	fibers
T9081	10911-10913	IN	denotes	to
T9082	10914-10917	DT	denotes	the
T9083	10918-10922	NN	denotes	area
T9084	10923-10925	IN	denotes	of
T9085	10926-10931	JJ	denotes	outer
T9087	10932-10936	NN	denotes	hair
T9086	10937-10942	NNS	denotes	cells
T9088	10943-10946	CC	denotes	and
T9089	10947-10950	DT	denotes	the
T9090	10951-10960	NN	denotes	formation
T9091	10961-10963	IN	denotes	of
T9092	10964-10969	JJ	denotes	inner
T9094	10970-10976	JJ	denotes	spiral
T9093	10977-10984	NNS	denotes	bundles
T9095	10985-10992	VBG	denotes	passing
T9096	10993-10998	IN	denotes	along
T9097	10999-11002	DT	denotes	the
T9099	11003-11006	JJ	denotes	few
T9100	11007-11015	JJ	denotes	immature
T9101	11016-11020	NN	denotes	hair
T9098	11021-11026	NNS	denotes	cells
T9102	11027-11028	-LRB-	denotes	(
T9104	11028-11029	NN	denotes	d
T9105	11029-11030	,	denotes	,
T9106	11030-11031	NN	denotes	f
T9107	11031-11032	,	denotes	,
T9103	11032-11033	NN	denotes	g
T9108	11033-11034	-RRB-	denotes	)
T9109	11034-11035	.	denotes	.
T9110	11035-11149	sentence	denotes	The pattern obtained with DiI tracing is identical to that obtained by acetylated tubulin immunoreactivity (f,g).
T9111	11036-11039	DT	denotes	The
T9112	11040-11047	NN	denotes	pattern
T9114	11048-11056	VBN	denotes	obtained
T9115	11057-11061	IN	denotes	with
T9116	11062-11065	NN	denotes	DiI
T9117	11066-11073	NN	denotes	tracing
T9113	11074-11076	VBZ	denotes	is
T9118	11077-11086	JJ	denotes	identical
T9119	11087-11089	IN	denotes	to
T9120	11090-11094	DT	denotes	that
T9121	11095-11103	VBN	denotes	obtained
T9122	11104-11106	IN	denotes	by
T9123	11107-11117	VBN	denotes	acetylated
T9124	11118-11125	NN	denotes	tubulin
T9125	11126-11142	NN	denotes	immunoreactivity
T9126	11143-11144	-LRB-	denotes	(
T9128	11144-11145	NN	denotes	f
T9129	11145-11146	,	denotes	,
T9127	11146-11147	NN	denotes	g
T9130	11147-11148	-RRB-	denotes	)
T9131	11148-11149	.	denotes	.
T9132	11149-11192	sentence	denotes	Bar indicates 1000 μm in a, 100 μm in b-g.
T9133	11150-11153	NNP	denotes	Bar
T9134	11154-11163	VBZ	denotes	indicates
T9135	11164-11168	CD	denotes	1000
T9136	11169-11171	NNS	denotes	μm
T9137	11172-11174	IN	denotes	in
T9138	11175-11176	DT	denotes	a
T9139	11176-11178	,	denotes	,
T9140	11178-11181	CD	denotes	100
T9141	11182-11184	NNS	denotes	μm
T9142	11185-11187	IN	denotes	in
T9143	11188-11189	NN	denotes	b
T9144	11189-11190	SYM	denotes	-
T9145	11190-11191	NN	denotes	g
T9146	11191-11192	.	denotes	.
T2859	11193-11196	DT	denotes	The
T2858	11193-11208	sentence	denotes	The cochlea at
T2860	11197-11198	NN	denotes	c
T2861	11198-11199	IN	denotes	o
T2862	11199-11200	NN	denotes	c
T2863	11200-11201	DT	denotes	h
T2864	11201-11202	NNS	denotes	l
T2865	11202-11203	DT	denotes	e
T2866	11203-11204	NN	denotes	a
T2867	11205-11206	JJ	denotes	a
T2868	11206-11207	DT	denotes	t
T2871	11208-11210	NN	denotes	P8
T2869	11208-11284	sentence	denotes	P8 shows more qualitative deviations from the normal pattern of innervation.
T2870	11211-11216	VBZ	denotes	shows
T2872	11217-11221	RBR	denotes	more
T2874	11222-11233	JJ	denotes	qualitative
T2873	11234-11244	NNS	denotes	deviations
T2875	11245-11249	IN	denotes	from
T2876	11250-11253	DT	denotes	the
T2878	11254-11260	JJ	denotes	normal
T2877	11261-11268	NN	denotes	pattern
T2879	11269-11271	IN	denotes	of
T2880	11272-11283	NN	denotes	innervation
T2881	11283-11284	.	denotes	.
T2882	11284-11429	sentence	denotes	For example, all three rows of outer hair cells now receive both afferent and efferent innervation in the base of control littermates (Fig. 3c).
T2883	11285-11288	IN	denotes	For
T2885	11289-11296	NN	denotes	example
T2886	11296-11298	,	denotes	,
T2887	11298-11301	DT	denotes	all
T2889	11302-11307	CD	denotes	three
T2888	11308-11312	NNS	denotes	rows
T2890	11313-11315	IN	denotes	of
T2891	11316-11321	JJ	denotes	outer
T2893	11322-11326	NN	denotes	hair
T2892	11327-11332	NNS	denotes	cells
T2894	11333-11336	RB	denotes	now
T2884	11337-11344	VBP	denotes	receive
T2895	11345-11349	CC	denotes	both
T2896	11350-11358	JJ	denotes	afferent
T2898	11359-11362	CC	denotes	and
T2899	11363-11371	JJ	denotes	efferent
T2897	11372-11383	NN	denotes	innervation
T2900	11384-11386	IN	denotes	in
T2901	11387-11390	DT	denotes	the
T2902	11391-11395	NN	denotes	base
T2903	11396-11398	IN	denotes	of
T2904	11399-11406	NN	denotes	control
T2905	11407-11418	NNS	denotes	littermates
T2906	11419-11420	-LRB-	denotes	(
T2908	11420-11424	NN	denotes	Fig.
T2907	11425-11427	NN	denotes	3c
T2909	11427-11428	-RRB-	denotes	)
T2910	11428-11429	.	denotes	.
T2911	11429-11525	sentence	denotes	However, no fibers extend to the outer hair cell region in Brn3c null mutants (Figs. 3d,3e,3f).
T2912	11430-11437	RB	denotes	However
T2914	11437-11439	,	denotes	,
T2915	11439-11441	DT	denotes	no
T2916	11442-11448	NNS	denotes	fibers
T2913	11449-11455	VBP	denotes	extend
T2917	11456-11458	IN	denotes	to
T2918	11459-11462	DT	denotes	the
T2920	11463-11468	JJ	denotes	outer
T2921	11469-11473	NN	denotes	hair
T2922	11474-11478	NN	denotes	cell
T2919	11479-11485	NN	denotes	region
T2923	11486-11488	IN	denotes	in
T2924	11489-11494	NN	denotes	Brn3c
T2926	11495-11499	JJ	denotes	null
T2925	11500-11507	NNS	denotes	mutants
T2927	11508-11509	-LRB-	denotes	(
T2929	11509-11514	NNS	denotes	Figs.
T2930	11515-11517	NN	denotes	3d
T2931	11517-11518	,	denotes	,
T2932	11518-11520	NN	denotes	3e
T2933	11520-11521	,	denotes	,
T2928	11521-11523	NN	denotes	3f
T2934	11523-11524	-RRB-	denotes	)
T2935	11524-11525	.	denotes	.
T2936	11525-11704	sentence	denotes	In control animals there is dense innervation of inner hair cells, whereas Brn3c null mutants show a curious aggregation of fibers near focal spots around the habenula perforata.
T2937	11526-11528	IN	denotes	In
T2939	11529-11536	NN	denotes	control
T2940	11537-11544	NNS	denotes	animals
T2941	11545-11550	EX	denotes	there
T2938	11551-11553	VBZ	denotes	is
T2942	11554-11559	JJ	denotes	dense
T2943	11560-11571	NN	denotes	innervation
T2944	11572-11574	IN	denotes	of
T2945	11575-11580	JJ	denotes	inner
T2947	11581-11585	NN	denotes	hair
T2946	11586-11591	NNS	denotes	cells
T2948	11591-11593	,	denotes	,
T2949	11593-11600	IN	denotes	whereas
T2951	11601-11606	NN	denotes	Brn3c
T2953	11607-11611	JJ	denotes	null
T2952	11612-11619	NNS	denotes	mutants
T2950	11620-11624	VBP	denotes	show
T2954	11625-11626	DT	denotes	a
T2956	11627-11634	JJ	denotes	curious
T2955	11635-11646	NN	denotes	aggregation
T2957	11647-11649	IN	denotes	of
T2958	11650-11656	NNS	denotes	fibers
T2959	11657-11661	IN	denotes	near
T2960	11662-11667	JJ	denotes	focal
T2961	11668-11673	NNS	denotes	spots
T2962	11674-11680	IN	denotes	around
T2963	11681-11684	DT	denotes	the
T2965	11685-11693	NN	denotes	habenula
T2964	11694-11703	NN	denotes	perforata
T2966	11703-11704	.	denotes	.
T2967	11704-11772	sentence	denotes	The apex shows less pronounced deviations from normal (Fig. 3f,3g).
T2968	11705-11708	DT	denotes	The
T2969	11709-11713	NN	denotes	apex
T2970	11714-11719	VBZ	denotes	shows
T2971	11720-11724	RBR	denotes	less
T2972	11725-11735	JJ	denotes	pronounced
T2973	11736-11746	NNS	denotes	deviations
T2974	11747-11751	IN	denotes	from
T2975	11752-11758	JJ	denotes	normal
T2976	11759-11760	-LRB-	denotes	(
T2978	11760-11764	NN	denotes	Fig.
T2979	11765-11767	NN	denotes	3f
T2980	11767-11768	,	denotes	,
T2977	11768-11770	NN	denotes	3g
T2981	11770-11771	-RRB-	denotes	)
T2982	11771-11772	.	denotes	.
T2983	11772-11869	sentence	denotes	However, as in the base, afferents and efferents extend sparingly to the outer hair cell region.
T2984	11773-11780	RB	denotes	However
T2986	11780-11782	,	denotes	,
T2987	11782-11784	IN	denotes	as
T2988	11785-11787	IN	denotes	in
T2989	11788-11791	DT	denotes	the
T2990	11792-11796	NN	denotes	base
T2991	11796-11798	,	denotes	,
T2992	11798-11807	NNS	denotes	afferents
T2993	11808-11811	CC	denotes	and
T2994	11812-11821	NNS	denotes	efferents
T2985	11822-11828	VBP	denotes	extend
T2995	11829-11838	RB	denotes	sparingly
T2996	11839-11841	IN	denotes	to
T2997	11842-11845	DT	denotes	the
T2999	11846-11851	JJ	denotes	outer
T3000	11852-11856	NN	denotes	hair
T3001	11857-11861	NN	denotes	cell
T2998	11862-11868	NN	denotes	region
T3002	11868-11869	.	denotes	.
T3003	11869-12055	sentence	denotes	There is formation of an inner spiral bundle communicating both afferents and efferents between the focal points where fibers appear to pass through the habenula perforata (Fig. 3f,3g).
T3004	11870-11875	EX	denotes	There
T3005	11876-11878	VBZ	denotes	is
T3006	11879-11888	NN	denotes	formation
T3007	11889-11891	IN	denotes	of
T3008	11892-11894	DT	denotes	an
T3010	11895-11900	JJ	denotes	inner
T3011	11901-11907	JJ	denotes	spiral
T3009	11908-11914	NN	denotes	bundle
T3012	11915-11928	VBG	denotes	communicating
T3013	11929-11933	DT	denotes	both
T3014	11934-11943	NNS	denotes	afferents
T3015	11944-11947	CC	denotes	and
T3016	11948-11957	NNS	denotes	efferents
T3017	11958-11965	IN	denotes	between
T3018	11966-11969	DT	denotes	the
T3020	11970-11975	JJ	denotes	focal
T3019	11976-11982	NNS	denotes	points
T3021	11983-11988	WRB	denotes	where
T3023	11989-11995	NNS	denotes	fibers
T3022	11996-12002	VBP	denotes	appear
T3024	12003-12005	TO	denotes	to
T3025	12006-12010	VB	denotes	pass
T3026	12011-12018	IN	denotes	through
T3027	12019-12022	DT	denotes	the
T3029	12023-12031	NN	denotes	habenula
T3028	12032-12041	NN	denotes	perforata
T3030	12042-12043	-LRB-	denotes	(
T3032	12043-12047	NNP	denotes	Fig.
T3033	12048-12050	CD	denotes	3f
T3034	12050-12051	,	denotes	,
T3031	12051-12053	NN	denotes	3g
T3035	12053-12054	-RRB-	denotes	)
T3036	12054-12055	.	denotes	.
T3037	12055-12177	sentence	denotes	As in newborn animals, efferent fibers closely follow the pattern of innervation displayed by afferents (data not shown).
T3038	12056-12058	IN	denotes	As
T3040	12059-12061	IN	denotes	in
T3041	12062-12069	JJ	denotes	newborn
T3042	12070-12077	NNS	denotes	animals
T3043	12077-12079	,	denotes	,
T3044	12079-12087	JJ	denotes	efferent
T3045	12088-12094	NNS	denotes	fibers
T3046	12095-12102	RB	denotes	closely
T3039	12103-12109	VBP	denotes	follow
T3047	12110-12113	DT	denotes	the
T3048	12114-12121	NN	denotes	pattern
T3049	12122-12124	IN	denotes	of
T3050	12125-12136	NN	denotes	innervation
T3051	12137-12146	VBN	denotes	displayed
T3052	12147-12149	IN	denotes	by
T3053	12150-12159	NNS	denotes	afferents
T3054	12160-12161	-LRB-	denotes	(
T3056	12161-12165	NNS	denotes	data
T3057	12166-12169	RB	denotes	not
T3055	12170-12175	VBN	denotes	shown
T3058	12175-12176	-RRB-	denotes	)
T3059	12176-12177	.	denotes	.
T3060	12177-12321	sentence	denotes	The limited qualitative effect of Brn3c null mutations on fiber loss is particularly obvious in the P8 Brn3c null mutant apical turn (Fig. 3g).
T3061	12178-12181	DT	denotes	The
T3063	12182-12189	JJ	denotes	limited
T3064	12190-12201	JJ	denotes	qualitative
T3062	12202-12208	NN	denotes	effect
T3066	12209-12211	IN	denotes	of
T3067	12212-12217	NN	denotes	Brn3c
T3069	12218-12222	JJ	denotes	null
T3068	12223-12232	NNS	denotes	mutations
T3070	12233-12235	IN	denotes	on
T3071	12236-12241	NN	denotes	fiber
T3072	12242-12246	NN	denotes	loss
T3065	12247-12249	VBZ	denotes	is
T3073	12250-12262	RB	denotes	particularly
T3074	12263-12270	JJ	denotes	obvious
T3075	12271-12273	IN	denotes	in
T3076	12274-12277	DT	denotes	the
T3078	12278-12280	NN	denotes	P8
T3079	12281-12286	NN	denotes	Brn3c
T3080	12287-12291	JJ	denotes	null
T3081	12292-12298	JJ	denotes	mutant
T3082	12299-12305	JJ	denotes	apical
T3077	12306-12310	NN	denotes	turn
T3083	12311-12312	-LRB-	denotes	(
T3085	12312-12316	NN	denotes	Fig.
T3084	12317-12319	NN	denotes	3g
T3086	12319-12320	-RRB-	denotes	)
T3087	12320-12321	.	denotes	.
T3088	12321-12478	sentence	denotes	Immunocytochemical and histochemcial data show the presence of only a few immature hair cells in the cochlea (Fig. 4), which amounted to about 1% (Table 1).
T3089	12322-12340	JJ	denotes	Immunocytochemical
T3091	12341-12344	CC	denotes	and
T3092	12345-12358	JJ	denotes	histochemcial
T3090	12359-12363	NNS	denotes	data
T3093	12364-12368	VBP	denotes	show
T3094	12369-12372	DT	denotes	the
T3095	12373-12381	NN	denotes	presence
T3096	12382-12384	IN	denotes	of
T3097	12385-12389	RB	denotes	only
T3099	12390-12391	DT	denotes	a
T3098	12392-12395	JJ	denotes	few
T3101	12396-12404	JJ	denotes	immature
T3102	12405-12409	NN	denotes	hair
T3100	12410-12415	NNS	denotes	cells
T3103	12416-12418	IN	denotes	in
T3104	12419-12422	DT	denotes	the
T3105	12423-12430	NN	denotes	cochlea
T3106	12431-12432	-LRB-	denotes	(
T3107	12432-12436	NN	denotes	Fig.
T3108	12437-12438	CD	denotes	4
T3109	12438-12439	-RRB-	denotes	)
T3110	12439-12441	,	denotes	,
T3111	12441-12446	WDT	denotes	which
T3112	12447-12455	VBD	denotes	amounted
T3113	12456-12458	IN	denotes	to
T3114	12459-12464	IN	denotes	about
T3115	12465-12466	CD	denotes	1
T3116	12466-12467	NN	denotes	%
T3117	12468-12469	-LRB-	denotes	(
T3119	12469-12474	JJ	denotes	Table
T3118	12475-12476	CD	denotes	1
T3120	12476-12477	-RRB-	denotes	)
T3121	12477-12478	.	denotes	.
T3122	12478-12544	sentence	denotes	Not a single immature hair cell forms in the apex of the cochlea.
T3123	12479-12482	RB	denotes	Not
T3125	12483-12484	DT	denotes	a
T3124	12485-12491	JJ	denotes	single
T3127	12492-12500	JJ	denotes	immature
T3128	12501-12505	NN	denotes	hair
T3126	12506-12510	NN	denotes	cell
T3129	12511-12516	VBZ	denotes	forms
T3130	12517-12519	IN	denotes	in
T3131	12520-12523	DT	denotes	the
T3132	12524-12528	NN	denotes	apex
T3133	12529-12531	IN	denotes	of
T3134	12532-12535	DT	denotes	the
T3135	12536-12543	NN	denotes	cochlea
T3136	12543-12544	.	denotes	.
T3137	12544-12673	sentence	denotes	In contrast, more immature hair cells are found in the appropriate position of hair cells in the vestibular endorgans (Table 1).
T3138	12545-12547	IN	denotes	In
T3140	12548-12556	NN	denotes	contrast
T3141	12556-12558	,	denotes	,
T3142	12558-12562	RBR	denotes	more
T3144	12563-12571	JJ	denotes	immature
T3145	12572-12576	NN	denotes	hair
T3143	12577-12582	NNS	denotes	cells
T3146	12583-12586	VBP	denotes	are
T3139	12587-12592	VBN	denotes	found
T3147	12593-12595	IN	denotes	in
T3148	12596-12599	DT	denotes	the
T3150	12600-12611	JJ	denotes	appropriate
T3149	12612-12620	NN	denotes	position
T3151	12621-12623	IN	denotes	of
T3152	12624-12628	NN	denotes	hair
T3153	12629-12634	NNS	denotes	cells
T3154	12635-12637	IN	denotes	in
T3155	12638-12641	DT	denotes	the
T3157	12642-12652	JJ	denotes	vestibular
T3156	12653-12662	NNS	denotes	endorgans
T3158	12663-12664	-LRB-	denotes	(
T3160	12664-12669	JJ	denotes	Table
T3159	12670-12671	CD	denotes	1
T3161	12671-12672	-RRB-	denotes	)
T3162	12672-12673	.	denotes	.
T3163	12673-12805	sentence	denotes	In fact, the vestibular end organs show no overt morphological defect other than the reduced presence of these immature hair cells.
T3164	12674-12676	IN	denotes	In
T3166	12677-12681	NN	denotes	fact
T3167	12681-12683	,	denotes	,
T3168	12683-12686	DT	denotes	the
T3170	12687-12697	JJ	denotes	vestibular
T3171	12698-12701	NN	denotes	end
T3169	12702-12708	NNS	denotes	organs
T3165	12709-12713	VBP	denotes	show
T3172	12714-12716	DT	denotes	no
T3174	12717-12722	JJ	denotes	overt
T3175	12723-12736	JJ	denotes	morphological
T3173	12737-12743	NN	denotes	defect
T3176	12744-12749	RB	denotes	other
T3177	12750-12754	IN	denotes	than
T3178	12755-12758	DT	denotes	the
T3180	12759-12766	VBN	denotes	reduced
T3179	12767-12775	NN	denotes	presence
T3181	12776-12778	IN	denotes	of
T3182	12779-12784	DT	denotes	these
T3184	12785-12793	JJ	denotes	immature
T3185	12794-12798	NN	denotes	hair
T3183	12799-12804	NNS	denotes	cells
T3186	12804-12805	.	denotes	.
T3187	12805-13049	sentence	denotes	Nerve fibers can be traced into the sensory epithelium of P0 and P8 Brn3c null mutants past the habenula perforata and there is a normal location of spiral sensory neurons in Rosenthal's canal in the apex of P8 Brn3c null mutants (Fig. 3d,3g).
T3188	12806-12811	NN	denotes	Nerve
T3189	12812-12818	NNS	denotes	fibers
T3191	12819-12822	MD	denotes	can
T3192	12823-12825	VB	denotes	be
T3190	12826-12832	VBN	denotes	traced
T3193	12833-12837	IN	denotes	into
T3194	12838-12841	DT	denotes	the
T3196	12842-12849	JJ	denotes	sensory
T3195	12850-12860	NN	denotes	epithelium
T3197	12861-12863	IN	denotes	of
T3198	12864-12866	NN	denotes	P0
T3200	12867-12870	CC	denotes	and
T3201	12871-12873	NN	denotes	P8
T3202	12874-12879	NN	denotes	Brn3c
T3203	12880-12884	JJ	denotes	null
T3199	12885-12892	NNS	denotes	mutants
T3204	12893-12897	IN	denotes	past
T3205	12898-12901	DT	denotes	the
T3207	12902-12910	NN	denotes	habenula
T3206	12911-12920	NNS	denotes	perforata
T3208	12921-12924	CC	denotes	and
T3209	12925-12930	EX	denotes	there
T3210	12931-12933	VBZ	denotes	is
T3211	12934-12935	DT	denotes	a
T3213	12936-12942	JJ	denotes	normal
T3212	12943-12951	NN	denotes	location
T3214	12952-12954	IN	denotes	of
T3215	12955-12961	JJ	denotes	spiral
T3217	12962-12969	JJ	denotes	sensory
T3216	12970-12977	NNS	denotes	neurons
T3218	12978-12980	IN	denotes	in
T3219	12981-12990	NNP	denotes	Rosenthal
T3221	12990-12992	POS	denotes	's
T3220	12993-12998	NN	denotes	canal
T3222	12999-13001	IN	denotes	in
T3223	13002-13005	DT	denotes	the
T3224	13006-13010	NN	denotes	apex
T3225	13011-13013	IN	denotes	of
T3226	13014-13016	NN	denotes	P8
T3228	13017-13022	NN	denotes	Brn3c
T3229	13023-13027	JJ	denotes	null
T3227	13028-13035	NNS	denotes	mutants
T3230	13036-13037	-LRB-	denotes	(
T3232	13037-13041	NNP	denotes	Fig.
T3233	13042-13044	CD	denotes	3d
T3234	13044-13045	,	denotes	,
T3231	13045-13047	NN	denotes	3g
T3235	13047-13048	-RRB-	denotes	)
T3236	13048-13049	.	denotes	.
T3237	13049-13090	sentence	denotes	The cochlea shows other defects as well.
T3238	13050-13053	DT	denotes	The
T3239	13054-13061	NN	denotes	cochlea
T3240	13062-13067	VBZ	denotes	shows
T3241	13068-13073	JJ	denotes	other
T3242	13074-13081	NNS	denotes	defects
T3243	13082-13084	RB	denotes	as
T3244	13085-13089	RB	denotes	well
T3245	13089-13090	.	denotes	.
T3246	13090-13209	sentence	denotes	For example, the spiral capillary is not found underneath the organ of Corti but in the spiral limbus nearby (Fig. 4).
T3247	13091-13094	IN	denotes	For
T3249	13095-13102	NN	denotes	example
T3250	13102-13104	,	denotes	,
T3251	13104-13107	DT	denotes	the
T3253	13108-13114	JJ	denotes	spiral
T3252	13115-13124	NN	denotes	capillary
T3254	13125-13127	VBZ	denotes	is
T3255	13128-13131	RB	denotes	not
T3248	13132-13137	VBN	denotes	found
T3256	13138-13148	IN	denotes	underneath
T3257	13149-13152	DT	denotes	the
T3258	13153-13158	NN	denotes	organ
T3259	13159-13161	IN	denotes	of
T3260	13162-13167	NNP	denotes	Corti
T3261	13168-13171	CC	denotes	but
T3262	13172-13174	IN	denotes	in
T3263	13175-13178	DT	denotes	the
T3265	13179-13185	JJ	denotes	spiral
T3264	13186-13192	NN	denotes	limbus
T3266	13193-13199	JJ	denotes	nearby
T3267	13200-13201	-LRB-	denotes	(
T3268	13201-13205	NN	denotes	Fig.
T3269	13206-13207	CD	denotes	4
T3270	13207-13208	-RRB-	denotes	)
T3271	13208-13209	.	denotes	.
T3272	13209-13528	sentence	denotes	The lack of immature hair cells seems to affect also the formation of pillar cells (undifferentiated almost throughout the cochlea; Fig. 4) and Deiters' cells (not recognizable based on their morphology), a suggestion consistent with recent molecular data on the interaction of hair cells and supporting cells [17,18].
T3273	13210-13213	DT	denotes	The
T3274	13214-13218	NN	denotes	lack
T3276	13219-13221	IN	denotes	of
T3277	13222-13230	JJ	denotes	immature
T3279	13231-13235	NN	denotes	hair
T3278	13236-13241	NNS	denotes	cells
T3275	13242-13247	VBZ	denotes	seems
T3280	13248-13250	TO	denotes	to
T3281	13251-13257	VB	denotes	affect
T3282	13258-13262	RB	denotes	also
T3283	13263-13266	DT	denotes	the
T3284	13267-13276	NN	denotes	formation
T3285	13277-13279	IN	denotes	of
T3286	13280-13286	JJ	denotes	pillar
T3287	13287-13292	NNS	denotes	cells
T3288	13293-13294	-LRB-	denotes	(
T3289	13294-13310	JJ	denotes	undifferentiated
T3290	13311-13317	RB	denotes	almost
T3291	13318-13328	IN	denotes	throughout
T3292	13329-13332	DT	denotes	the
T3293	13333-13340	NN	denotes	cochlea
T3294	13340-13341	:	denotes	;
T3295	13342-13346	NN	denotes	Fig.
T3296	13347-13348	CD	denotes	4
T3297	13348-13349	-RRB-	denotes	)
T3298	13350-13353	CC	denotes	and
T3299	13354-13361	NNS	denotes	Deiters
T3301	13361-13362	POS	denotes	'
T3300	13363-13368	NNS	denotes	cells
T3302	13369-13370	-LRB-	denotes	(
T3303	13370-13373	RB	denotes	not
T3304	13374-13386	JJ	denotes	recognizable
T3305	13387-13392	VBN	denotes	based
T3306	13393-13395	IN	denotes	on
T3307	13396-13401	PRP$	denotes	their
T3308	13402-13412	NN	denotes	morphology
T3309	13412-13413	-RRB-	denotes	)
T3310	13413-13415	,	denotes	,
T3311	13415-13416	DT	denotes	a
T3312	13417-13427	NN	denotes	suggestion
T3313	13428-13438	JJ	denotes	consistent
T3314	13439-13443	IN	denotes	with
T3315	13444-13450	JJ	denotes	recent
T3317	13451-13460	JJ	denotes	molecular
T3316	13461-13465	NNS	denotes	data
T3318	13466-13468	IN	denotes	on
T3319	13469-13472	DT	denotes	the
T3320	13473-13484	NN	denotes	interaction
T3321	13485-13487	IN	denotes	of
T3322	13488-13492	NN	denotes	hair
T3323	13493-13498	NNS	denotes	cells
T3324	13499-13502	CC	denotes	and
T3325	13503-13513	VBG	denotes	supporting
T3326	13514-13519	NNS	denotes	cells
T3327	13520-13521	-LRB-	denotes	[
T3329	13521-13523	CD	denotes	17
T3330	13523-13524	,	denotes	,
T3328	13524-13526	CD	denotes	18
T3331	13526-13527	-RRB-	denotes	]
T3332	13527-13528	.	denotes	.
T3333	13528-13529	sentence	denotes
T9258	13539-13542	DT	denotes	The
T9259	13543-13555	NN	denotes	distribution
T9261	13556-13558	IN	denotes	of
T9262	13559-13563	NN	denotes	hair
T9263	13564-13569	NNS	denotes	cells
T9264	13570-13572	IN	denotes	as
T9265	13573-13583	VBN	denotes	identified
T9266	13584-13588	IN	denotes	with
T9267	13589-13595	NN	denotes	MyoVII
T9268	13596-13615	NN	denotes	immunocytochemistry
T9269	13616-13618	VBZ	denotes	is
T9260	13619-13624	VBN	denotes	shown
T9270	13625-13628	IN	denotes	for
T9271	13629-13630	JJ	denotes	7
T9273	13630-13631	HYPH	denotes	-
T9272	13631-13634	JJ	denotes	day
T9274	13635-13638	JJ	denotes	old
T9276	13639-13644	JJ	denotes	whole
T9277	13645-13652	VBN	denotes	mounted
T9275	13653-13660	NN	denotes	cochlea
T9278	13661-13662	-LRB-	denotes	(
T9279	13662-13663	NN	denotes	a
T9280	13663-13664	SYM	denotes	-
T9281	13664-13665	NN	denotes	d
T9282	13665-13666	-RRB-	denotes	)
T9283	13667-13670	CC	denotes	and
T9284	13671-13674	DT	denotes	the
T9285	13675-13685	NN	denotes	appearance
T9287	13686-13688	IN	denotes	of
T9288	13689-13700	JJ	denotes	cytological
T9289	13701-13716	NN	denotes	differentiation
T9290	13717-13719	VBZ	denotes	is
T9286	13720-13725	VBN	denotes	shown
T9291	13726-13728	IN	denotes	as
T9292	13729-13737	VBN	denotes	revealed
T9293	13738-13742	IN	denotes	with
T9294	13743-13748	NN	denotes	epoxy
T9295	13749-13754	NN	denotes	resin
T9296	13755-13763	NNS	denotes	sections
T9297	13764-13766	IN	denotes	in
T9298	13767-13768	CD	denotes	7
T9300	13768-13769	HYPH	denotes	-
T9299	13769-13772	NN	denotes	day
T9301	13773-13776	JJ	denotes	old
T9303	13777-13778	-LRB-	denotes	(
T9304	13778-13779	NN	denotes	e
T9305	13779-13780	SYM	denotes	-
T9306	13780-13781	NN	denotes	g
T9307	13781-13782	-RRB-	denotes	)
T9308	13783-13786	CC	denotes	and
T9309	13787-13788	CD	denotes	6
T9311	13788-13789	HYPH	denotes	-
T9310	13789-13794	NN	denotes	month
T9312	13795-13798	JJ	denotes	old
T9314	13799-13800	-LRB-	denotes	(
T9315	13800-13801	NN	denotes	h
T9316	13801-13802	-RRB-	denotes	)
T9313	13803-13810	NN	denotes	control
T9317	13811-13812	-LRB-	denotes	(
T9319	13812-13813	NN	denotes	a
T9320	13813-13814	,	denotes	,
T9321	13814-13815	NN	denotes	c
T9322	13815-13816	,	denotes	,
T9318	13816-13817	NN	denotes	e
T9323	13817-13818	-RRB-	denotes	)
T9324	13819-13822	CC	denotes	and
T9325	13823-13828	NN	denotes	Brn3c
T9326	13829-13835	JJ	denotes	mutant
T9302	13836-13844	NNS	denotes	cochleae
T9327	13845-13846	-LRB-	denotes	(
T9328	13846-13847	NN	denotes	b
T9329	13847-13848	,	denotes	,
T9330	13848-13849	NN	denotes	d
T9331	13849-13850	,	denotes	,
T9332	13850-13851	NN	denotes	f
T9333	13851-13852	SYM	denotes	-
T9334	13852-13853	NN	denotes	h
T9335	13853-13854	-RRB-	denotes	)
T9336	13854-13855	.	denotes	.
T9337	13855-14012	sentence	denotes	Note the uniform staining with this antibody of all three rows of outer hair cells (OHC) and the single row of inner hair cells (IHC) in the wildtype (a,c).
T9338	13856-13860	VB	denotes	Note
T9339	13861-13864	DT	denotes	the
T9341	13865-13872	JJ	denotes	uniform
T9340	13873-13881	NN	denotes	staining
T9342	13882-13886	IN	denotes	with
T9343	13887-13891	DT	denotes	this
T9344	13892-13900	NN	denotes	antibody
T9345	13901-13903	IN	denotes	of
T9346	13904-13907	DT	denotes	all
T9348	13908-13913	CD	denotes	three
T9347	13914-13918	NNS	denotes	rows
T9349	13919-13921	IN	denotes	of
T9350	13922-13927	JJ	denotes	outer
T9352	13928-13932	NN	denotes	hair
T9351	13933-13938	NNS	denotes	cells
T9353	13939-13940	-LRB-	denotes	(
T9354	13940-13943	NN	denotes	OHC
T9355	13943-13944	-RRB-	denotes	)
T9356	13945-13948	CC	denotes	and
T9357	13949-13952	DT	denotes	the
T9359	13953-13959	JJ	denotes	single
T9358	13960-13963	NN	denotes	row
T9360	13964-13966	IN	denotes	of
T9361	13967-13972	JJ	denotes	inner
T9363	13973-13977	NN	denotes	hair
T9362	13978-13983	NNS	denotes	cells
T9364	13984-13985	-LRB-	denotes	(
T9365	13985-13988	NN	denotes	IHC
T9366	13988-13989	-RRB-	denotes	)
T9367	13990-13992	IN	denotes	in
T9368	13993-13996	DT	denotes	the
T9369	13997-14005	NN	denotes	wildtype
T9370	14006-14007	-LRB-	denotes	(
T9372	14007-14008	NN	denotes	a
T9373	14008-14009	,	denotes	,
T9371	14009-14010	NN	denotes	c
T9374	14010-14011	-RRB-	denotes	)
T9375	14011-14012	.	denotes	.
T9376	14012-14194	sentence	denotes	In contrast, only few immature hair cells (iHC) are found in the basal turn of the mutant littermate (b) and only an occasional cell is MyoVII immunopositive in the middle turn (d).
T9377	14013-14015	IN	denotes	In
T9379	14016-14024	NN	denotes	contrast
T9380	14024-14026	,	denotes	,
T9381	14026-14030	RB	denotes	only
T9383	14031-14034	JJ	denotes	few
T9384	14035-14043	JJ	denotes	immature
T9385	14044-14048	NN	denotes	hair
T9382	14049-14054	NNS	denotes	cells
T9386	14055-14056	-LRB-	denotes	(
T9387	14056-14059	NN	denotes	iHC
T9388	14059-14060	-RRB-	denotes	)
T9389	14061-14064	VBP	denotes	are
T9378	14065-14070	VBN	denotes	found
T9390	14071-14073	IN	denotes	in
T9391	14074-14077	DT	denotes	the
T9393	14078-14083	JJ	denotes	basal
T9392	14084-14088	NN	denotes	turn
T9394	14089-14091	IN	denotes	of
T9395	14092-14095	DT	denotes	the
T9397	14096-14102	JJ	denotes	mutant
T9396	14103-14113	NN	denotes	littermate
T9398	14114-14115	-LRB-	denotes	(
T9399	14115-14116	NN	denotes	b
T9400	14116-14117	-RRB-	denotes	)
T9401	14118-14121	CC	denotes	and
T9402	14122-14126	RB	denotes	only
T9404	14127-14129	DT	denotes	an
T9405	14130-14140	JJ	denotes	occasional
T9403	14141-14145	NN	denotes	cell
T9406	14146-14148	VBZ	denotes	is
T9407	14149-14155	NN	denotes	MyoVII
T9408	14156-14170	JJ	denotes	immunopositive
T9409	14171-14173	IN	denotes	in
T9410	14174-14177	DT	denotes	the
T9412	14178-14184	JJ	denotes	middle
T9411	14185-14189	NN	denotes	turn
T9413	14190-14191	-LRB-	denotes	(
T9414	14191-14192	NN	denotes	d
T9415	14192-14193	-RRB-	denotes	)
T9416	14193-14194	.	denotes	.
T9417	14194-14252	sentence	denotes	No MyoVII positive immature hair cells exist in the apex.
T9418	14195-14197	DT	denotes	No
T9420	14198-14204	NN	denotes	MyoVII
T9421	14205-14213	JJ	denotes	positive
T9422	14214-14222	JJ	denotes	immature
T9423	14223-14227	NN	denotes	hair
T9419	14228-14233	NNS	denotes	cells
T9424	14234-14239	VBP	denotes	exist
T9425	14240-14242	IN	denotes	in
T9426	14243-14246	DT	denotes	the
T9427	14247-14251	NN	denotes	apex
T9428	14251-14252	.	denotes	.
T9429	14252-14394	sentence	denotes	Sections show the degree of differentiation of hair cells and their innervating fibers stained with tubulin immunocytochemistry (arrow; e-h).
T9430	14253-14261	NNS	denotes	Sections
T9431	14262-14266	VBP	denotes	show
T9432	14267-14270	DT	denotes	the
T9433	14271-14277	NN	denotes	degree
T9434	14278-14280	IN	denotes	of
T9435	14281-14296	NN	denotes	differentiation
T9436	14297-14299	IN	denotes	of
T9437	14300-14304	NN	denotes	hair
T9438	14305-14310	NNS	denotes	cells
T9439	14311-14314	CC	denotes	and
T9440	14315-14320	PRP$	denotes	their
T9442	14321-14332	JJ	denotes	innervating
T9441	14333-14339	NNS	denotes	fibers
T9443	14340-14347	VBN	denotes	stained
T9444	14348-14352	IN	denotes	with
T9445	14353-14360	NN	denotes	tubulin
T9446	14361-14380	NN	denotes	immunocytochemistry
T9447	14381-14382	-LRB-	denotes	(
T9448	14382-14387	NN	denotes	arrow
T9449	14387-14388	:	denotes	;
T9450	14389-14390	NN	denotes	e
T9451	14390-14391	SYM	denotes	-
T9452	14391-14392	NN	denotes	h
T9453	14392-14393	-RRB-	denotes	)
T9454	14393-14394	.	denotes	.
T9455	14394-14530	sentence	denotes	Note the presence of a spiral capillary (C) under the tunnel of Corti separating the inner and outer hair cells in the P7 wildtype (e).
T9456	14395-14399	VB	denotes	Note
T9457	14400-14403	DT	denotes	the
T9458	14404-14412	NN	denotes	presence
T9459	14413-14415	IN	denotes	of
T9460	14416-14417	DT	denotes	a
T9462	14418-14424	JJ	denotes	spiral
T9461	14425-14434	NN	denotes	capillary
T9463	14435-14436	-LRB-	denotes	(
T9464	14436-14437	NN	denotes	C
T9465	14437-14438	-RRB-	denotes	)
T9466	14439-14444	IN	denotes	under
T9467	14445-14448	DT	denotes	the
T9468	14449-14455	NN	denotes	tunnel
T9469	14456-14458	IN	denotes	of
T9470	14459-14464	NNP	denotes	Corti
T9471	14465-14475	VBG	denotes	separating
T9472	14476-14479	DT	denotes	the
T9474	14480-14485	JJ	denotes	inner
T9475	14486-14489	CC	denotes	and
T9476	14490-14495	JJ	denotes	outer
T9477	14496-14500	NN	denotes	hair
T9473	14501-14506	NNS	denotes	cells
T9478	14507-14509	IN	denotes	in
T9479	14510-14513	DT	denotes	the
T9481	14514-14516	NN	denotes	P7
T9480	14517-14525	NN	denotes	wildtype
T9482	14526-14527	-LRB-	denotes	(
T9483	14527-14528	NN	denotes	e
T9484	14528-14529	-RRB-	denotes	)
T9485	14529-14530	.	denotes	.
T9486	14530-14659	sentence	denotes	In contrast, no such capillary is present underneath the organ of Corti in mutants (f-h) and no tunnel of Corti is found either.
T9487	14531-14533	IN	denotes	In
T9489	14534-14542	NN	denotes	contrast
T9490	14542-14544	,	denotes	,
T9491	14544-14546	DT	denotes	no
T9493	14547-14551	JJ	denotes	such
T9492	14552-14561	NN	denotes	capillary
T9488	14562-14564	VBZ	denotes	is
T9494	14565-14572	JJ	denotes	present
T9495	14573-14583	IN	denotes	underneath
T9496	14584-14587	DT	denotes	the
T9497	14588-14593	NN	denotes	organ
T9498	14594-14596	IN	denotes	of
T9499	14597-14602	NNP	denotes	Corti
T9500	14603-14605	IN	denotes	in
T9501	14606-14613	NNS	denotes	mutants
T9502	14614-14615	-LRB-	denotes	(
T9503	14615-14616	NN	denotes	f
T9504	14616-14617	SYM	denotes	-
T9505	14617-14618	NN	denotes	h
T9506	14618-14619	-RRB-	denotes	)
T9507	14620-14623	CC	denotes	and
T9508	14624-14626	DT	denotes	no
T9509	14627-14633	NN	denotes	tunnel
T9511	14634-14636	IN	denotes	of
T9512	14637-14642	NNP	denotes	Corti
T9513	14643-14645	VBZ	denotes	is
T9510	14646-14651	VBN	denotes	found
T9514	14652-14658	RB	denotes	either
T9515	14658-14659	.	denotes	.
T9516	14659-14751	sentence	denotes	A tectorial membrane forms (TM) but otherwise there is little cyotological differentiation.
T9517	14660-14661	DT	denotes	A
T9519	14662-14671	JJ	denotes	tectorial
T9518	14672-14680	NN	denotes	membrane
T9520	14681-14686	VBZ	denotes	forms
T9521	14687-14688	-LRB-	denotes	(
T9522	14688-14690	NN	denotes	TM
T9523	14690-14691	-RRB-	denotes	)
T9524	14692-14695	CC	denotes	but
T9525	14696-14705	RB	denotes	otherwise
T9527	14706-14711	EX	denotes	there
T9526	14712-14714	VBZ	denotes	is
T9528	14715-14721	JJ	denotes	little
T9530	14722-14734	JJ	denotes	cyotological
T9529	14735-14750	NN	denotes	differentiation
T9531	14750-14751	.	denotes	.
T9532	14751-14841	sentence	denotes	Note that tubulin-positive fibers can be traced to the immature cells until 6 months (h).
T9533	14752-14756	VB	denotes	Note
T9534	14757-14761	IN	denotes	that
T9536	14762-14769	JJ	denotes	tubulin
T9538	14769-14770	HYPH	denotes	-
T9537	14770-14778	JJ	denotes	positive
T9539	14779-14785	NNS	denotes	fibers
T9540	14786-14789	MD	denotes	can
T9541	14790-14792	VB	denotes	be
T9535	14793-14799	VBN	denotes	traced
T9542	14800-14802	IN	denotes	to
T9543	14803-14806	DT	denotes	the
T9545	14807-14815	JJ	denotes	immature
T9544	14816-14821	NNS	denotes	cells
T9546	14822-14827	IN	denotes	until
T9547	14828-14829	CD	denotes	6
T9548	14830-14836	NNS	denotes	months
T9549	14837-14838	-LRB-	denotes	(
T9550	14838-14839	NN	denotes	h
T9551	14839-14840	-RRB-	denotes	)
T9552	14840-14841	.	denotes	.
T9553	14841-14868	sentence	denotes	Bar in c indicates 100 μm.
T9554	14842-14845	NN	denotes	Bar
T9556	14846-14848	IN	denotes	in
T9557	14849-14850	NN	denotes	c
T9555	14851-14860	VBZ	denotes	indicates
T9558	14861-14864	CD	denotes	100
T9559	14865-14867	NNS	denotes	μm
T9560	14867-14868	.	denotes	.
T10496	14878-14885	NNS	denotes	Numbers
T10497	14886-14888	IN	denotes	of
T10498	14889-14893	NN	denotes	hair
T10499	14894-14899	NNS	denotes	cells
T10500	14900-14903	CC	denotes	and
T10501	14904-14911	JJ	denotes	sensory
T10502	14912-14919	NNS	denotes	neurons
T10503	14920-14922	IN	denotes	in
T10504	14923-14925	NN	denotes	P7
T10505	14926-14934	NN	denotes	wildtype
T10507	14935-14938	CC	denotes	and
T10508	14939-14944	NN	denotes	Brn3c
T10509	14945-14951	JJ	denotes	mutant
T10506	14952-14963	NNS	denotes	littermates
T3335	15760-15761	NN	denotes	C
T3334	15760-15762	sentence	denotes	Co
T3336	15761-15762	NN	denotes	o
T3338	15762-15763	JJ	denotes	m
T3337	15762-15764	sentence	denotes	mp
T3339	15763-15764	JJ	denotes	p
T3342	15764-15766	JJ	denotes	ar
T3340	15764-15768	sentence	denotes	aris
T3343	15766-15767	NN	denotes	i
T3341	15767-15768	NNS	denotes	s
T3345	15768-15770	NNS	denotes	on
T3344	15768-15777	sentence	denotes	on of num
T3346	15771-15772	VBP	denotes	o
T3347	15772-15773	IN	denotes	f
T3348	15774-15775	NN	denotes	n
T3349	15775-15776	NN	denotes	u
T3350	15776-15777	NN	denotes	m
T3352	15777-15779	NN	denotes	be
T3351	15777-15784	sentence	denotes	bers of
T3353	15779-15781	VBZ	denotes	rs
T3354	15782-15783	RB	denotes	o
T3355	15783-15784	NN	denotes	f
T3356	15784-15795	sentence	denotes	immature h
T3357	15785-15786	JJ	denotes	i
T3358	15786-15793	JJ	denotes	mmature
T3359	15794-15795	NNS	denotes	h
T3361	15795-15796	NN	denotes	a
T3360	15795-15797	sentence	denotes	ai
T3362	15796-15797	IN	denotes	i
T3364	15797-15798	NNS	denotes	r
T3363	15797-15809	sentence	denotes	r cells in t
T3365	15799-15804	NNS	denotes	cells
T3366	15805-15807	IN	denotes	in
T3367	15808-15809	NN	denotes	t
T3369	15809-15810	RB	denotes	h
T3368	15809-15810	sentence	denotes	h
T3372	15810-15811	NNS	denotes	e
T3370	15810-15969	sentence	denotes	e vestibular and cochlear areas (Fig. 4) with the numbers of surviving vestibular and cochlear sensory neurons does not show any correlation (Table 1; Fig. 5).
T3374	15812-15822	JJ	denotes	vestibular
T3375	15823-15826	CC	denotes	and
T3376	15827-15835	JJ	denotes	cochlear
T3373	15836-15841	NNS	denotes	areas
T3377	15842-15843	-LRB-	denotes	(
T3379	15843-15847	NN	denotes	Fig.
T3378	15848-15849	CD	denotes	4
T3380	15849-15850	-RRB-	denotes	)
T3381	15851-15855	IN	denotes	with
T3382	15856-15859	DT	denotes	the
T3383	15860-15867	NNS	denotes	numbers
T3384	15868-15870	IN	denotes	of
T3385	15871-15880	VBG	denotes	surviving
T3387	15881-15891	JJ	denotes	vestibular
T3388	15892-15895	CC	denotes	and
T3389	15896-15904	JJ	denotes	cochlear
T3390	15905-15912	JJ	denotes	sensory
T3386	15913-15920	NNS	denotes	neurons
T3391	15921-15925	VBZ	denotes	does
T3392	15926-15929	RB	denotes	not
T3371	15930-15934	VB	denotes	show
T3393	15935-15938	DT	denotes	any
T3394	15939-15950	NN	denotes	correlation
T3395	15951-15952	-LRB-	denotes	(
T3397	15952-15957	JJ	denotes	Table
T3398	15958-15959	CD	denotes	1
T3399	15959-15960	:	denotes	;
T3396	15961-15965	NN	denotes	Fig.
T3400	15966-15967	CD	denotes	5
T3401	15967-15968	-RRB-	denotes	)
T3402	15968-15969	.	denotes	.
T3403	15969-16093	sentence	denotes	Only a few undifferentiated hair cells were detected by MyoVIIa immunostaining and only in the basal region of the cochlea.
T3404	15970-15974	RB	denotes	Only
T3406	15975-15976	DT	denotes	a
T3405	15977-15980	JJ	denotes	few
T3408	15981-15997	JJ	denotes	undifferentiated
T3409	15998-16002	NN	denotes	hair
T3407	16003-16008	NNS	denotes	cells
T3411	16009-16013	VBD	denotes	were
T3410	16014-16022	VBN	denotes	detected
T3412	16023-16025	IN	denotes	by
T3413	16026-16033	NN	denotes	MyoVIIa
T3414	16034-16048	NN	denotes	immunostaining
T3415	16049-16052	CC	denotes	and
T3416	16053-16057	RB	denotes	only
T3417	16058-16060	IN	denotes	in
T3418	16061-16064	DT	denotes	the
T3420	16065-16070	JJ	denotes	basal
T3419	16071-16077	NN	denotes	region
T3421	16078-16080	IN	denotes	of
T3422	16081-16084	DT	denotes	the
T3423	16085-16092	NN	denotes	cochlea
T3424	16092-16093	.	denotes	.
T3425	16093-16284	sentence	denotes	And yet only about 50% of cochlear sensory neurons are lost overall with a less severe loss in the apex in which we could not detect any immature hair cells with MyoVIIa immunocytochemistry.
T3426	16094-16097	CC	denotes	And
T3428	16098-16101	RB	denotes	yet
T3429	16102-16106	RB	denotes	only
T3431	16107-16112	IN	denotes	about
T3430	16113-16115	CD	denotes	50
T3432	16115-16116	NN	denotes	%
T3433	16117-16119	IN	denotes	of
T3434	16120-16128	JJ	denotes	cochlear
T3436	16129-16136	JJ	denotes	sensory
T3435	16137-16144	NNS	denotes	neurons
T3437	16145-16148	VBP	denotes	are
T3427	16149-16153	VBN	denotes	lost
T3438	16154-16161	RB	denotes	overall
T3439	16162-16166	IN	denotes	with
T3440	16167-16168	DT	denotes	a
T3442	16169-16173	RBR	denotes	less
T3443	16174-16180	JJ	denotes	severe
T3441	16181-16185	NN	denotes	loss
T3444	16186-16188	IN	denotes	in
T3445	16189-16192	DT	denotes	the
T3446	16193-16197	NN	denotes	apex
T3447	16198-16200	IN	denotes	in
T3449	16201-16206	WDT	denotes	which
T3450	16207-16209	PRP	denotes	we
T3451	16210-16215	MD	denotes	could
T3452	16216-16219	RB	denotes	not
T3448	16220-16226	VB	denotes	detect
T3453	16227-16230	DT	denotes	any
T3455	16231-16239	JJ	denotes	immature
T3456	16240-16244	NN	denotes	hair
T3454	16245-16250	NNS	denotes	cells
T3457	16251-16255	IN	denotes	with
T3458	16256-16263	NN	denotes	MyoVIIa
T3459	16264-16283	NN	denotes	immunocytochemistry
T3460	16283-16284	.	denotes	.
T3461	16284-16385	sentence	denotes	This does not exclude the possibility that even less differentiated hair cells may form in the apex.
T3462	16285-16289	DT	denotes	This
T3464	16290-16294	VBZ	denotes	does
T3465	16295-16298	RB	denotes	not
T3463	16299-16306	VB	denotes	exclude
T3466	16307-16310	DT	denotes	the
T3467	16311-16322	NN	denotes	possibility
T3468	16323-16327	IN	denotes	that
T3470	16328-16332	RB	denotes	even
T3471	16333-16337	RBR	denotes	less
T3472	16338-16352	VBN	denotes	differentiated
T3474	16353-16357	NN	denotes	hair
T3473	16358-16363	NNS	denotes	cells
T3475	16364-16367	MD	denotes	may
T3469	16368-16372	VB	denotes	form
T3476	16373-16375	IN	denotes	in
T3477	16376-16379	DT	denotes	the
T3478	16380-16384	NN	denotes	apex
T3479	16384-16385	.	denotes	.
T3480	16385-17230	sentence	denotes	Figure 5 This graph shows the reduction in sensory neurons (top) and in hair cells (bottom) between 7-day old wildtype and Brn3c null mutant littermates. Note the sharp reduction to 1% in the cochlear immature hair cells (bottom) whereas spiral sensory neurons (SG) are only reduced by 50% (top). In contrast, 20% immature hair cells could be identified in vestibular sensory epithelia (saccule has been selected; bottom) whereas only around 15% of the vestibular sensory neurons survive to this age (VG; top). For details on the data see Table 1. The central projection of DiI and DiA traces fibers to the cochlear nuclei (Fig. 6) where they show a clear segregation of apical turn afferents (Fig. 6, green) and basal turn afferents (Fig. 6, red) in both the entering cochlear nerve (Fig. 6a) and the ventral cochlear nucleus (VCN) (Fig. 6b).
T9610	16396-16400	DT	denotes	This
T9611	16401-16406	NN	denotes	graph
T9612	16407-16412	VBZ	denotes	shows
T9613	16413-16416	DT	denotes	the
T9614	16417-16426	NN	denotes	reduction
T9615	16427-16429	IN	denotes	in
T9616	16430-16437	JJ	denotes	sensory
T9617	16438-16445	NNS	denotes	neurons
T9618	16446-16447	-LRB-	denotes	(
T9619	16447-16450	NN	denotes	top
T9620	16450-16451	-RRB-	denotes	)
T9621	16452-16455	CC	denotes	and
T9622	16456-16458	IN	denotes	in
T9623	16459-16463	NN	denotes	hair
T9624	16464-16469	NNS	denotes	cells
T9625	16470-16471	-LRB-	denotes	(
T9626	16471-16477	NN	denotes	bottom
T9627	16477-16478	-RRB-	denotes	)
T9628	16479-16486	IN	denotes	between
T9629	16487-16488	JJ	denotes	7
T9631	16488-16489	HYPH	denotes	-
T9630	16489-16492	JJ	denotes	day
T9632	16493-16496	JJ	denotes	old
T9633	16497-16505	NN	denotes	wildtype
T9635	16506-16509	CC	denotes	and
T9636	16510-16515	NN	denotes	Brn3c
T9637	16516-16520	JJ	denotes	null
T9638	16521-16527	JJ	denotes	mutant
T9634	16528-16539	NNS	denotes	littermates
T9639	16539-16540	.	denotes	.
T9640	16540-16683	sentence	denotes	Note the sharp reduction to 1% in the cochlear immature hair cells (bottom) whereas spiral sensory neurons (SG) are only reduced by 50% (top).
T9641	16541-16545	VB	denotes	Note
T9642	16546-16549	DT	denotes	the
T9644	16550-16555	JJ	denotes	sharp
T9643	16556-16565	NN	denotes	reduction
T9645	16566-16568	IN	denotes	to
T9646	16569-16570	CD	denotes	1
T9647	16570-16571	NN	denotes	%
T9648	16572-16574	IN	denotes	in
T9649	16575-16578	DT	denotes	the
T9651	16579-16587	JJ	denotes	cochlear
T9652	16588-16596	JJ	denotes	immature
T9653	16597-16601	NN	denotes	hair
T9650	16602-16607	NNS	denotes	cells
T9654	16608-16609	-LRB-	denotes	(
T9655	16609-16615	NN	denotes	bottom
T9656	16615-16616	-RRB-	denotes	)
T9657	16617-16624	IN	denotes	whereas
T9659	16625-16631	JJ	denotes	spiral
T9661	16632-16639	JJ	denotes	sensory
T9660	16640-16647	NNS	denotes	neurons
T9662	16648-16649	-LRB-	denotes	(
T9663	16649-16651	NN	denotes	SG
T9664	16651-16652	-RRB-	denotes	)
T9665	16653-16656	VBP	denotes	are
T9666	16657-16661	RB	denotes	only
T9658	16662-16669	VBN	denotes	reduced
T9667	16670-16672	IN	denotes	by
T9668	16673-16675	CD	denotes	50
T9669	16675-16676	NN	denotes	%
T9670	16677-16678	-LRB-	denotes	(
T9671	16678-16681	NN	denotes	top
T9672	16681-16682	-RRB-	denotes	)
T9673	16682-16683	.	denotes	.
T9674	16683-16897	sentence	denotes	In contrast, 20% immature hair cells could be identified in vestibular sensory epithelia (saccule has been selected; bottom) whereas only around 15% of the vestibular sensory neurons survive to this age (VG; top).
T9675	16684-16686	IN	denotes	In
T9677	16687-16695	NN	denotes	contrast
T9678	16695-16697	,	denotes	,
T9679	16697-16699	CD	denotes	20
T9680	16699-16700	NN	denotes	%
T9682	16701-16709	JJ	denotes	immature
T9683	16710-16714	NN	denotes	hair
T9681	16715-16720	NNS	denotes	cells
T9684	16721-16726	MD	denotes	could
T9685	16727-16729	VB	denotes	be
T9676	16730-16740	VBN	denotes	identified
T9686	16741-16743	IN	denotes	in
T9687	16744-16754	JJ	denotes	vestibular
T9689	16755-16762	JJ	denotes	sensory
T9688	16763-16772	NNS	denotes	epithelia
T9690	16773-16774	-LRB-	denotes	(
T9692	16774-16781	NN	denotes	saccule
T9694	16782-16785	VBZ	denotes	has
T9695	16786-16790	VBN	denotes	been
T9693	16791-16799	VBN	denotes	selected
T9696	16799-16800	:	denotes	;
T9691	16801-16807	NN	denotes	bottom
T9697	16807-16808	-RRB-	denotes	)
T9698	16809-16816	IN	denotes	whereas
T9700	16817-16821	RB	denotes	only
T9702	16822-16828	IN	denotes	around
T9701	16829-16831	CD	denotes	15
T9703	16831-16832	NN	denotes	%
T9704	16833-16835	IN	denotes	of
T9705	16836-16839	DT	denotes	the
T9707	16840-16850	JJ	denotes	vestibular
T9708	16851-16858	JJ	denotes	sensory
T9706	16859-16866	NNS	denotes	neurons
T9699	16867-16874	VBP	denotes	survive
T9709	16875-16877	IN	denotes	to
T9710	16878-16882	DT	denotes	this
T9711	16883-16886	NN	denotes	age
T9712	16887-16888	-LRB-	denotes	(
T9714	16888-16890	NN	denotes	VG
T9715	16890-16891	:	denotes	;
T9713	16892-16895	NN	denotes	top
T9716	16895-16896	-RRB-	denotes	)
T9717	16896-16897	.	denotes	.
T9718	16897-16934	sentence	denotes	For details on the data see Table 1.
T9719	16898-16901	IN	denotes	For
T9721	16902-16909	NNS	denotes	details
T9722	16910-16912	IN	denotes	on
T9723	16913-16916	DT	denotes	the
T9724	16917-16921	NNS	denotes	data
T9720	16922-16925	VBP	denotes	see
T9725	16926-16931	NN	denotes	Table
T9726	16932-16933	CD	denotes	1
T9727	16933-16934	.	denotes	.
T3481	16935-16938	DT	denotes	The
T3483	16939-16946	JJ	denotes	central
T3482	16947-16957	NN	denotes	projection
T3485	16958-16960	IN	denotes	of
T3486	16961-16964	NN	denotes	DiI
T3487	16965-16968	CC	denotes	and
T3488	16969-16972	NN	denotes	DiA
T3484	16973-16979	VBZ	denotes	traces
T3489	16980-16986	NNS	denotes	fibers
T3490	16987-16989	IN	denotes	to
T3491	16990-16993	DT	denotes	the
T3493	16994-17002	JJ	denotes	cochlear
T3492	17003-17009	NNS	denotes	nuclei
T3494	17010-17011	-LRB-	denotes	(
T3495	17011-17015	NN	denotes	Fig.
T3496	17016-17017	CD	denotes	6
T3497	17017-17018	-RRB-	denotes	)
T3498	17019-17024	WRB	denotes	where
T3500	17025-17029	PRP	denotes	they
T3499	17030-17034	VBP	denotes	show
T3501	17035-17036	DT	denotes	a
T3503	17037-17042	JJ	denotes	clear
T3502	17043-17054	NN	denotes	segregation
T3504	17055-17057	IN	denotes	of
T3505	17058-17064	JJ	denotes	apical
T3506	17065-17069	NN	denotes	turn
T3507	17070-17079	NNS	denotes	afferents
T3508	17080-17081	-LRB-	denotes	(
T3509	17081-17085	NN	denotes	Fig.
T3510	17086-17087	CD	denotes	6
T3511	17087-17089	,	denotes	,
T3512	17089-17094	JJ	denotes	green
T3513	17094-17095	-RRB-	denotes	)
T3514	17096-17099	CC	denotes	and
T3515	17100-17105	JJ	denotes	basal
T3516	17106-17110	NN	denotes	turn
T3517	17111-17120	NNS	denotes	afferents
T3518	17121-17122	-LRB-	denotes	(
T3519	17122-17126	NN	denotes	Fig.
T3520	17127-17128	CD	denotes	6
T3521	17128-17130	,	denotes	,
T3522	17130-17133	JJ	denotes	red
T3523	17133-17134	-RRB-	denotes	)
T3524	17135-17137	IN	denotes	in
T3525	17138-17142	CC	denotes	both
T3527	17143-17146	DT	denotes	the
T3528	17147-17155	VBG	denotes	entering
T3529	17156-17164	JJ	denotes	cochlear
T3526	17165-17170	NN	denotes	nerve
T3530	17171-17172	-LRB-	denotes	(
T3532	17172-17176	NN	denotes	Fig.
T3531	17177-17179	NN	denotes	6a
T3533	17179-17180	-RRB-	denotes	)
T3534	17181-17184	CC	denotes	and
T3535	17185-17188	DT	denotes	the
T3537	17189-17196	JJ	denotes	ventral
T3538	17197-17205	JJ	denotes	cochlear
T3536	17206-17213	NN	denotes	nucleus
T3539	17214-17215	-LRB-	denotes	(
T3540	17215-17218	NN	denotes	VCN
T3541	17218-17219	-RRB-	denotes	)
T3542	17220-17221	-LRB-	denotes	(
T3544	17221-17225	NNP	denotes	Fig.
T3543	17226-17228	NNP	denotes	6b
T3545	17228-17229	-RRB-	denotes	)
T3546	17229-17230	.	denotes	.
T3547	17230-17554	sentence	denotes	Qualitative comparable central projections are found in wildtype control littermates (data not shown) and suggest that the central projection to cochlear nuclei is at least until P8 in mice not critically dependent on auditory information or other hair cell-mediated influences, in agreement with recent suggestions [5,19].
T3548	17231-17242	JJ	denotes	Qualitative
T3550	17243-17253	JJ	denotes	comparable
T3551	17254-17261	JJ	denotes	central
T3549	17262-17273	NNS	denotes	projections
T3553	17274-17277	VBP	denotes	are
T3552	17278-17283	VBN	denotes	found
T3554	17284-17286	IN	denotes	in
T3555	17287-17295	JJ	denotes	wildtype
T3557	17296-17303	NN	denotes	control
T3556	17304-17315	NNS	denotes	littermates
T3558	17316-17317	-LRB-	denotes	(
T3560	17317-17321	NNS	denotes	data
T3561	17322-17325	RB	denotes	not
T3559	17326-17331	VBN	denotes	shown
T3562	17331-17332	-RRB-	denotes	)
T3563	17333-17336	CC	denotes	and
T3564	17337-17344	VBP	denotes	suggest
T3565	17345-17349	IN	denotes	that
T3567	17350-17353	DT	denotes	the
T3569	17354-17361	JJ	denotes	central
T3568	17362-17372	NN	denotes	projection
T3570	17373-17375	IN	denotes	to
T3571	17376-17384	JJ	denotes	cochlear
T3572	17385-17391	NNS	denotes	nuclei
T3566	17392-17394	VBZ	denotes	is
T3573	17395-17397	RB	denotes	at
T3574	17398-17403	RBS	denotes	least
T3575	17404-17409	IN	denotes	until
T3576	17410-17412	NN	denotes	P8
T3577	17413-17415	IN	denotes	in
T3578	17416-17420	NNS	denotes	mice
T3579	17421-17424	RB	denotes	not
T3580	17425-17435	RB	denotes	critically
T3581	17436-17445	JJ	denotes	dependent
T3582	17446-17448	IN	denotes	on
T3583	17449-17457	JJ	denotes	auditory
T3584	17458-17469	NN	denotes	information
T3585	17470-17472	CC	denotes	or
T3586	17473-17478	JJ	denotes	other
T3588	17479-17483	NN	denotes	hair
T3590	17484-17488	JJ	denotes	cell
T3591	17488-17489	HYPH	denotes	-
T3589	17489-17497	JJ	denotes	mediated
T3587	17498-17508	NNS	denotes	influences
T3592	17508-17510	,	denotes	,
T3593	17510-17512	IN	denotes	in
T3594	17513-17522	NN	denotes	agreement
T3595	17523-17527	IN	denotes	with
T3596	17528-17534	JJ	denotes	recent
T3597	17535-17546	NNS	denotes	suggestions
T3598	17547-17548	-LRB-	denotes	[
T3600	17548-17549	CD	denotes	5
T3601	17549-17550	,	denotes	,
T3599	17550-17552	CD	denotes	19
T3602	17552-17553	-RRB-	denotes	]
T3603	17553-17554	.	denotes	.
T9768	17565-17570	DT	denotes	These
T9770	17571-17579	JJ	denotes	confocal
T9769	17580-17586	NNS	denotes	images
T9771	17587-17591	VBP	denotes	show
T9772	17592-17595	DT	denotes	the
T9774	17596-17606	NN	denotes	projection
T9773	17607-17614	NN	denotes	pattern
T9775	17615-17617	IN	denotes	of
T9776	17618-17619	DT	denotes	a
T9778	17620-17622	NN	denotes	P8
T9779	17623-17628	NN	denotes	Brn3c
T9780	17629-17633	JJ	denotes	null
T9781	17634-17640	JJ	denotes	mutant
T9777	17641-17646	NN	denotes	mouse
T9782	17646-17647	.	denotes	.
T9783	17647-17738	sentence	denotes	DiI (red) was inserted into the basal turn, DiA (green) was inserted into the apical turn.
T9784	17648-17651	NN	denotes	DiI
T9786	17652-17653	-LRB-	denotes	(
T9787	17653-17656	JJ	denotes	red
T9788	17656-17657	-RRB-	denotes	)
T9789	17658-17661	VBD	denotes	was
T9785	17662-17670	VBN	denotes	inserted
T9791	17671-17675	IN	denotes	into
T9792	17676-17679	DT	denotes	the
T9794	17680-17685	JJ	denotes	basal
T9793	17686-17690	NN	denotes	turn
T9795	17690-17692	,	denotes	,
T9796	17692-17695	NN	denotes	DiA
T9797	17696-17697	-LRB-	denotes	(
T9798	17697-17702	JJ	denotes	green
T9799	17702-17703	-RRB-	denotes	)
T9800	17704-17707	VBD	denotes	was
T9790	17708-17716	VBN	denotes	inserted
T9801	17717-17721	IN	denotes	into
T9802	17722-17725	DT	denotes	the
T9804	17726-17732	JJ	denotes	apical
T9803	17733-17737	NN	denotes	turn
T9805	17737-17738	.	denotes	.
T9806	17738-17943	sentence	denotes	Note that the fibers run in discrete bundles inside the cochlear nerve (a), spiral around each other near the root and project to distinct medial and lateral divisions of the ventral cochlear nucleus (b).
T9807	17739-17743	VB	denotes	Note
T9808	17744-17748	IN	denotes	that
T9810	17749-17752	DT	denotes	the
T9811	17753-17759	NNS	denotes	fibers
T9809	17760-17763	VBP	denotes	run
T9812	17764-17766	IN	denotes	in
T9813	17767-17775	JJ	denotes	discrete
T9814	17776-17783	NNS	denotes	bundles
T9815	17784-17790	IN	denotes	inside
T9816	17791-17794	DT	denotes	the
T9818	17795-17803	JJ	denotes	cochlear
T9817	17804-17809	NN	denotes	nerve
T9819	17810-17811	-LRB-	denotes	(
T9820	17811-17812	DT	denotes	a
T9821	17812-17813	-RRB-	denotes	)
T9822	17813-17815	,	denotes	,
T9823	17815-17821	VBP	denotes	spiral
T9824	17822-17828	IN	denotes	around
T9825	17829-17833	DT	denotes	each
T9826	17834-17839	JJ	denotes	other
T9827	17840-17844	IN	denotes	near
T9828	17845-17848	DT	denotes	the
T9829	17849-17853	NN	denotes	root
T9830	17854-17857	CC	denotes	and
T9831	17858-17865	VBP	denotes	project
T9832	17866-17868	IN	denotes	to
T9833	17869-17877	JJ	denotes	distinct
T9835	17878-17884	JJ	denotes	medial
T9836	17885-17888	CC	denotes	and
T9837	17889-17896	JJ	denotes	lateral
T9834	17897-17906	NNS	denotes	divisions
T9838	17907-17909	IN	denotes	of
T9839	17910-17913	DT	denotes	the
T9841	17914-17921	JJ	denotes	ventral
T9842	17922-17930	JJ	denotes	cochlear
T9840	17931-17938	NN	denotes	nucleus
T9843	17939-17940	-LRB-	denotes	(
T9844	17940-17941	NN	denotes	b
T9845	17941-17942	-RRB-	denotes	)
T9846	17942-17943	.	denotes	.
T9847	17943-18084	sentence	denotes	These data suggest that a crude cochleotopic projection can form independently of any signaling from the immature hair cells of the cochlea.
T9848	17944-17949	DT	denotes	These
T9849	17950-17954	NNS	denotes	data
T9850	17955-17962	VBP	denotes	suggest
T9851	17963-17967	IN	denotes	that
T9853	17968-17969	DT	denotes	a
T9855	17970-17975	JJ	denotes	crude
T9856	17976-17988	JJ	denotes	cochleotopic
T9854	17989-17999	NN	denotes	projection
T9857	18000-18003	MD	denotes	can
T9852	18004-18008	VB	denotes	form
T9858	18009-18022	RB	denotes	independently
T9859	18023-18025	IN	denotes	of
T9860	18026-18029	DT	denotes	any
T9861	18030-18039	NN	denotes	signaling
T9862	18040-18044	IN	denotes	from
T9863	18045-18048	DT	denotes	the
T9865	18049-18057	JJ	denotes	immature
T9866	18058-18062	NN	denotes	hair
T9864	18063-18068	NNS	denotes	cells
T9867	18069-18071	IN	denotes	of
T9868	18072-18075	DT	denotes	the
T9869	18076-18083	NN	denotes	cochlea
T9870	18083-18084	.	denotes	.
T9871	18084-18159	sentence	denotes	Arrow indicates the efferent bundle as it leaves the afferent fiber tract.
T9872	18085-18090	NN	denotes	Arrow
T9873	18091-18100	VBZ	denotes	indicates
T9874	18101-18104	DT	denotes	the
T9876	18105-18113	JJ	denotes	efferent
T9875	18114-18120	NN	denotes	bundle
T9877	18121-18123	IN	denotes	as
T9879	18124-18126	PRP	denotes	it
T9878	18127-18133	VBZ	denotes	leaves
T9880	18134-18137	DT	denotes	the
T9882	18138-18146	JJ	denotes	afferent
T9883	18147-18152	NN	denotes	fiber
T9881	18153-18158	NN	denotes	tract
T9884	18158-18159	.	denotes	.
T9885	18159-18181	sentence	denotes	Bar indicates 100 μm.
T9886	18160-18163	NNP	denotes	Bar
T9887	18164-18173	VBZ	denotes	indicates
T9888	18174-18177	CD	denotes	100
T9889	18178-18180	NNS	denotes	μm
T9890	18180-18181	.	denotes	.
T3723	18183-18184	CD	denotes	6
T3724	18185-18191	NNS	denotes	months
T3726	18192-18197	NN	denotes	Brn3c
T3727	18198-18202	JJ	denotes	null
T3725	18203-18210	NNS	denotes	mutants
T3728	18210-18399	sentence	denotes	Very few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants.
T3729	18211-18215	JJ	denotes	Very
T3730	18216-18219	JJ	denotes	few
T3731	18220-18226	NNS	denotes	fibers
T3733	18227-18228	-LRB-	denotes	(
T3734	18228-18232	CC	denotes	both
T3735	18233-18241	JJ	denotes	afferent
T3736	18242-18245	CC	denotes	and
T3737	18246-18254	JJ	denotes	efferent
T3738	18254-18255	-RRB-	denotes	)
T3739	18256-18258	IN	denotes	to
T3740	18259-18262	DT	denotes	the
T3742	18263-18273	JJ	denotes	vestibular
T3741	18274-18283	NNS	denotes	epithelia
T3732	18284-18290	VBP	denotes	remain
T3743	18291-18292	-LRB-	denotes	(
T3745	18292-18296	NNP	denotes	Fig.
T3744	18297-18299	NN	denotes	7a
T3746	18299-18300	-RRB-	denotes	)
T3747	18300-18302	,	denotes	,
T3748	18302-18306	RB	denotes	thus
T3749	18307-18317	VBG	denotes	displaying
T3750	18318-18319	DT	denotes	a
T3752	18320-18327	JJ	denotes	further
T3751	18328-18337	NN	denotes	reduction
T3753	18338-18340	IN	denotes	of
T3754	18341-18344	DT	denotes	the
T3755	18345-18352	NN	denotes	pattern
T3756	18353-18355	IN	denotes	of
T3757	18356-18367	NN	denotes	innervation
T3758	18368-18373	VBN	denotes	found
T3759	18374-18376	IN	denotes	in
T3760	18377-18379	NN	denotes	P8
T3762	18380-18385	NN	denotes	Brn3c
T3763	18386-18390	JJ	denotes	null
T3761	18391-18398	NNS	denotes	mutants
T3764	18398-18399	.	denotes	.
T3765	18399-18571	sentence	denotes	Notably, there are still a number of fibers extending from the very few vestibular sensory neurons to the canal epithelia, in particular the horizontal canal (Fig. 7a,7b).
T3766	18400-18407	RB	denotes	Notably
T3768	18407-18409	,	denotes	,
T3769	18409-18414	EX	denotes	there
T3767	18415-18418	VBP	denotes	are
T3770	18419-18424	RB	denotes	still
T3771	18425-18426	DT	denotes	a
T3772	18427-18433	NN	denotes	number
T3773	18434-18436	IN	denotes	of
T3774	18437-18443	NNS	denotes	fibers
T3775	18444-18453	VBG	denotes	extending
T3776	18454-18458	IN	denotes	from
T3777	18459-18462	DT	denotes	the
T3779	18463-18467	RB	denotes	very
T3780	18468-18471	JJ	denotes	few
T3781	18472-18482	JJ	denotes	vestibular
T3782	18483-18490	JJ	denotes	sensory
T3778	18491-18498	NNS	denotes	neurons
T3783	18499-18501	IN	denotes	to
T3784	18502-18505	DT	denotes	the
T3786	18506-18511	JJ	denotes	canal
T3785	18512-18521	NNS	denotes	epithelia
T3787	18521-18523	,	denotes	,
T3788	18523-18525	IN	denotes	in
T3790	18526-18536	JJ	denotes	particular
T3791	18537-18540	DT	denotes	the
T3792	18541-18551	JJ	denotes	horizontal
T3789	18552-18557	NN	denotes	canal
T3793	18558-18559	-LRB-	denotes	(
T3795	18559-18563	NN	denotes	Fig.
T3796	18564-18566	NN	denotes	7a
T3797	18566-18567	,	denotes	,
T3794	18567-18569	NN	denotes	7b
T3798	18569-18570	-RRB-	denotes	)
T3799	18570-18571	.	denotes	.
T3800	18571-18729	sentence	denotes	Only very few fibers extend to the utricle and saccule with the reduction of efferents to these epithelia being almost complete (Fig. 7a and data not shown).
T3801	18572-18576	RB	denotes	Only
T3803	18577-18581	RB	denotes	very
T3804	18582-18585	JJ	denotes	few
T3802	18586-18592	NNS	denotes	fibers
T3805	18593-18599	VBP	denotes	extend
T3806	18600-18602	IN	denotes	to
T3807	18603-18606	DT	denotes	the
T3808	18607-18614	NN	denotes	utricle
T3809	18615-18618	CC	denotes	and
T3810	18619-18626	NN	denotes	saccule
T3811	18627-18631	IN	denotes	with
T3812	18632-18635	DT	denotes	the
T3813	18636-18645	NN	denotes	reduction
T3815	18646-18648	IN	denotes	of
T3816	18649-18658	NNS	denotes	efferents
T3817	18659-18661	IN	denotes	to
T3818	18662-18667	DT	denotes	these
T3819	18668-18677	NNS	denotes	epithelia
T3814	18678-18683	VBG	denotes	being
T3820	18684-18690	RB	denotes	almost
T3821	18691-18699	JJ	denotes	complete
T3822	18700-18701	-LRB-	denotes	(
T3824	18701-18705	NN	denotes	Fig.
T3823	18706-18708	NN	denotes	7a
T3825	18709-18712	CC	denotes	and
T3826	18713-18717	NNS	denotes	data
T3828	18718-18721	RB	denotes	not
T3827	18722-18727	VBN	denotes	shown
T3829	18727-18728	-RRB-	denotes	)
T3830	18728-18729	.	denotes	.
T3831	18729-18900	sentence	denotes	Comparable to control mice, there is some transcellular labeling with DiI to cells apparently contacted by the afferent fibers in the Brn3c null mutant utricle (Fig. 7b).
T3832	18730-18740	JJ	denotes	Comparable
T3834	18741-18743	IN	denotes	to
T3835	18744-18751	NN	denotes	control
T3836	18752-18756	NNS	denotes	mice
T3837	18756-18758	,	denotes	,
T3838	18758-18763	EX	denotes	there
T3833	18764-18766	VBZ	denotes	is
T3839	18767-18771	DT	denotes	some
T3841	18772-18785	JJ	denotes	transcellular
T3840	18786-18794	NN	denotes	labeling
T3842	18795-18799	IN	denotes	with
T3843	18800-18803	NN	denotes	DiI
T3844	18804-18806	IN	denotes	to
T3845	18807-18812	NNS	denotes	cells
T3846	18813-18823	RB	denotes	apparently
T3847	18824-18833	VBN	denotes	contacted
T3848	18834-18836	IN	denotes	by
T3849	18837-18840	DT	denotes	the
T3851	18841-18849	JJ	denotes	afferent
T3850	18850-18856	NNS	denotes	fibers
T3852	18857-18859	IN	denotes	in
T3853	18860-18863	DT	denotes	the
T3855	18864-18869	NN	denotes	Brn3c
T3856	18870-18874	JJ	denotes	null
T3857	18875-18881	JJ	denotes	mutant
T3854	18882-18889	NN	denotes	utricle
T3858	18890-18891	-LRB-	denotes	(
T3860	18891-18895	NN	denotes	Fig.
T3859	18896-18898	NN	denotes	7b
T3861	18898-18899	-RRB-	denotes	)
T3862	18899-18900	.	denotes	.
T3863	18900-19003	sentence	denotes	However, these cells could not be clearly identified as immature hair cells based on their morphology.
T3864	18901-18908	RB	denotes	However
T3866	18908-18910	,	denotes	,
T3867	18910-18915	DT	denotes	these
T3868	18916-18921	NNS	denotes	cells
T3869	18922-18927	MD	denotes	could
T3870	18928-18931	RB	denotes	not
T3871	18932-18934	VB	denotes	be
T3872	18935-18942	RB	denotes	clearly
T3865	18943-18953	VBN	denotes	identified
T3873	18954-18956	IN	denotes	as
T3874	18957-18965	JJ	denotes	immature
T3876	18966-18970	NN	denotes	hair
T3875	18971-18976	NNS	denotes	cells
T3877	18977-18982	VBN	denotes	based
T3878	18983-18985	IN	denotes	on
T3879	18986-18991	PRP$	denotes	their
T3880	18992-19002	NN	denotes	morphology
T3881	19002-19003	.	denotes	.
T3882	19003-19004	sentence	denotes
T9944	19014-19017	DT	denotes	The
T9945	19018-19029	NN	denotes	innervation
T9947	19030-19032	IN	denotes	of
T9948	19033-19040	JJ	denotes	sensory
T9949	19041-19050	NNS	denotes	epithelia
T9950	19051-19053	VBZ	denotes	is
T9946	19054-19059	VBN	denotes	shown
T9951	19060-19062	IN	denotes	in
T9952	19063-19064	JJ	denotes	6
T9954	19064-19065	HYPH	denotes	-
T9953	19065-19070	JJ	denotes	month
T9955	19071-19074	JJ	denotes	old
T9957	19075-19080	NN	denotes	Brn3c
T9958	19081-19085	JJ	denotes	null
T9959	19086-19092	JJ	denotes	mutant
T9956	19093-19097	NNS	denotes	mice
T9960	19097-19098	.	denotes	.
T9961	19098-19257	sentence	denotes	Compared to P8 animals there is a further reduction of fiber density to vestibular sensory epithelia, but fibers can be traced to all sensory epithelia (a,b).
T9962	19099-19107	VBN	denotes	Compared
T9964	19108-19110	IN	denotes	to
T9965	19111-19113	NN	denotes	P8
T9966	19114-19121	NNS	denotes	animals
T9967	19122-19127	EX	denotes	there
T9963	19128-19130	VBZ	denotes	is
T9968	19131-19132	DT	denotes	a
T9970	19133-19140	JJ	denotes	further
T9969	19141-19150	NN	denotes	reduction
T9971	19151-19153	IN	denotes	of
T9972	19154-19159	NN	denotes	fiber
T9973	19160-19167	NN	denotes	density
T9974	19168-19170	IN	denotes	to
T9975	19171-19181	JJ	denotes	vestibular
T9977	19182-19189	JJ	denotes	sensory
T9976	19190-19199	NNS	denotes	epithelia
T9978	19199-19201	,	denotes	,
T9979	19201-19204	CC	denotes	but
T9980	19205-19211	NNS	denotes	fibers
T9982	19212-19215	MD	denotes	can
T9983	19216-19218	VB	denotes	be
T9981	19219-19225	VBN	denotes	traced
T9984	19226-19228	IN	denotes	to
T9985	19229-19232	DT	denotes	all
T9987	19233-19240	JJ	denotes	sensory
T9986	19241-19250	NNS	denotes	epithelia
T9988	19251-19252	-LRB-	denotes	(
T9990	19252-19253	NN	denotes	a
T9991	19253-19254	,	denotes	,
T9989	19254-19255	NN	denotes	b
T9992	19255-19256	-RRB-	denotes	)
T9993	19256-19257	.	denotes	.
T9994	19257-19359	sentence	denotes	Transcellular labeling with DiI (b) suggest contacts between these afferents and immature hair cells.
T9995	19258-19271	JJ	denotes	Transcellular
T9996	19272-19280	NN	denotes	labeling
T9998	19281-19285	IN	denotes	with
T9999	19286-19289	NN	denotes	DiI
T10000	19290-19291	-LRB-	denotes	(
T10001	19291-19292	NN	denotes	b
T10002	19292-19293	-RRB-	denotes	)
T9997	19294-19301	VBP	denotes	suggest
T10003	19302-19310	NNS	denotes	contacts
T10004	19311-19318	IN	denotes	between
T10005	19319-19324	DT	denotes	these
T10006	19325-19334	NNS	denotes	afferents
T10007	19335-19338	CC	denotes	and
T10008	19339-19347	JJ	denotes	immature
T10010	19348-19352	NN	denotes	hair
T10009	19353-19358	NNS	denotes	cells
T10011	19358-19359	.	denotes	.
T10012	19359-19443	sentence	denotes	The cochlea shows a much reduced density of radial bundles, even in the apex (c,d).
T10013	19360-19363	DT	denotes	The
T10014	19364-19371	NN	denotes	cochlea
T10015	19372-19377	VBZ	denotes	shows
T10016	19378-19379	DT	denotes	a
T10018	19380-19384	RB	denotes	much
T10019	19385-19392	VBN	denotes	reduced
T10017	19393-19400	NN	denotes	density
T10020	19401-19403	IN	denotes	of
T10021	19404-19410	JJ	denotes	radial
T10022	19411-19418	NNS	denotes	bundles
T10023	19418-19420	,	denotes	,
T10024	19420-19424	RB	denotes	even
T10025	19425-19427	IN	denotes	in
T10026	19428-19431	DT	denotes	the
T10027	19432-19436	NN	denotes	apex
T10028	19437-19438	-LRB-	denotes	(
T10030	19438-19439	NN	denotes	c
T10031	19439-19440	,	denotes	,
T10029	19440-19441	NN	denotes	d
T10032	19441-19442	-RRB-	denotes	)
T10033	19442-19443	.	denotes	.
T10034	19443-19618	sentence	denotes	However, spiral sensory neurons are present in Rosenthal's canal (c,d) and fibers extend to the organ of Corti where they form longitudinal tracts in the immature epithelium.
T10035	19444-19451	RB	denotes	However
T10037	19451-19453	,	denotes	,
T10038	19453-19459	JJ	denotes	spiral
T10040	19460-19467	JJ	denotes	sensory
T10039	19468-19475	NNS	denotes	neurons
T10036	19476-19479	VBP	denotes	are
T10041	19480-19487	JJ	denotes	present
T10042	19488-19490	IN	denotes	in
T10043	19491-19500	NNP	denotes	Rosenthal
T10045	19500-19502	POS	denotes	's
T10044	19503-19508	NN	denotes	canal
T10046	19509-19510	-LRB-	denotes	(
T10048	19510-19511	NN	denotes	c
T10049	19511-19512	,	denotes	,
T10047	19512-19513	NN	denotes	d
T10050	19513-19514	-RRB-	denotes	)
T10051	19515-19518	CC	denotes	and
T10052	19519-19525	NNS	denotes	fibers
T10053	19526-19532	VBP	denotes	extend
T10054	19533-19535	IN	denotes	to
T10055	19536-19539	DT	denotes	the
T10056	19540-19545	NN	denotes	organ
T10057	19546-19548	IN	denotes	of
T10058	19549-19554	NNP	denotes	Corti
T10059	19555-19560	WRB	denotes	where
T10061	19561-19565	PRP	denotes	they
T10060	19566-19570	VBP	denotes	form
T10062	19571-19583	JJ	denotes	longitudinal
T10063	19584-19590	NNS	denotes	tracts
T10064	19591-19593	IN	denotes	in
T10065	19594-19597	DT	denotes	the
T10067	19598-19606	JJ	denotes	immature
T10066	19607-19617	NN	denotes	epithelium
T10068	19617-19618	.	denotes	.
T10069	19618-19640	sentence	denotes	Bar indicates 100 μm.
T10070	19619-19622	NNP	denotes	Bar
T10071	19623-19632	VBZ	denotes	indicates
T10072	19633-19636	CD	denotes	100
T10073	19637-19639	NNS	denotes	μm
T10074	19639-19640	.	denotes	.
T3884	19641-19644	DT	denotes	The
T3883	19641-19646	sentence	denotes	The c
T3885	19645-19646	NN	denotes	c
T3887	19646-19647	VBN	denotes	o
T3886	19646-19653	sentence	denotes	ochlea,
T3888	19647-19648	NN	denotes	c
T3889	19648-19650	NNS	denotes	hl
T3890	19650-19651	NNS	denotes	e
T3891	19651-19652	MD	denotes	a
T3892	19652-19653	,	denotes	,
T3893	19653-19655	sentence	denotes	m
T3894	19654-19655	JJ	denotes	m
T3896	19655-19656	NN	denotes	o
T3895	19655-19660	sentence	denotes	ost p
T3897	19656-19657	VBZ	denotes	s
T3898	19657-19658	NN	denotes	t
T3899	19659-19660	NN	denotes	p
T3901	19660-19661	RB	denotes	r
T3900	19660-19666	sentence	denotes	romine
T3902	19661-19662	JJ	denotes	o
T3903	19662-19663	VBP	denotes	m
T3904	19663-19665	JJ	denotes	in
T3905	19665-19666	DT	denotes	e
T3907	19666-19668	VBZ	denotes	nt
T3906	19666-19668	sentence	denotes	nt
T3909	19668-19669	NN	denotes	l
T3908	19668-19768	sentence	denotes	ly the apex, receives many afferent fibers, which form an interrupted inner spiral bundle (Fig. 7c).
T3911	19669-19670	RB	denotes	y
T3913	19671-19674	DT	denotes	the
T3912	19675-19679	NN	denotes	apex
T3914	19679-19681	,	denotes	,
T3910	19681-19689	VBZ	denotes	receives
T3915	19690-19694	JJ	denotes	many
T3917	19695-19703	JJ	denotes	afferent
T3916	19704-19710	NNS	denotes	fibers
T3918	19710-19712	,	denotes	,
T3919	19712-19717	WDT	denotes	which
T3920	19718-19722	VBP	denotes	form
T3921	19723-19725	DT	denotes	an
T3923	19726-19737	JJ	denotes	interrupted
T3924	19738-19743	JJ	denotes	inner
T3925	19744-19750	JJ	denotes	spiral
T3922	19751-19757	NN	denotes	bundle
T3926	19758-19759	-LRB-	denotes	(
T3928	19759-19763	NN	denotes	Fig.
T3927	19764-19766	NN	denotes	7c
T3929	19766-19767	-RRB-	denotes	)
T3930	19767-19768	.	denotes	.
T3931	19768-19827	sentence	denotes	Some of the radial fiber bundles are myelinated (Fig. 7d).
T3932	19769-19773	DT	denotes	Some
T3934	19774-19776	IN	denotes	of
T3935	19777-19780	DT	denotes	the
T3937	19781-19787	JJ	denotes	radial
T3938	19788-19793	NN	denotes	fiber
T3936	19794-19801	NNS	denotes	bundles
T3933	19802-19805	VBP	denotes	are
T3939	19806-19816	JJ	denotes	myelinated
T3940	19817-19818	-LRB-	denotes	(
T3941	19818-19822	NN	denotes	Fig.
T3942	19823-19825	CD	denotes	7d
T3943	19825-19826	-RRB-	denotes	)
T3944	19826-19827	.	denotes	.
T3945	19827-19940	sentence	denotes	Only an occasional fiber extends beyond the inner spiral bundle into the area of the outer hair cells (Fig. 7d).
T3946	19828-19832	RB	denotes	Only
T3948	19833-19835	DT	denotes	an
T3949	19836-19846	JJ	denotes	occasional
T3947	19847-19852	NN	denotes	fiber
T3950	19853-19860	VBZ	denotes	extends
T3951	19861-19867	IN	denotes	beyond
T3952	19868-19871	DT	denotes	the
T3954	19872-19877	JJ	denotes	inner
T3955	19878-19884	JJ	denotes	spiral
T3953	19885-19891	NN	denotes	bundle
T3956	19892-19896	IN	denotes	into
T3957	19897-19900	DT	denotes	the
T3958	19901-19905	NN	denotes	area
T3959	19906-19908	IN	denotes	of
T3960	19909-19912	DT	denotes	the
T3962	19913-19918	JJ	denotes	outer
T3963	19919-19923	NN	denotes	hair
T3961	19924-19929	NNS	denotes	cells
T3964	19930-19931	-LRB-	denotes	(
T3965	19931-19935	NN	denotes	Fig.
T3966	19936-19938	CD	denotes	7d
T3967	19938-19939	-RRB-	denotes	)
T3968	19939-19940	.	denotes	.
T3969	19940-20052	sentence	denotes	Even at this late stage in maturation there are still numerous spiral neurons present in the apex (Fig. 7c,7d).
T3970	19941-19945	RB	denotes	Even
T3971	19946-19948	IN	denotes	at
T3973	19949-19953	DT	denotes	this
T3975	19954-19958	JJ	denotes	late
T3974	19959-19964	NN	denotes	stage
T3976	19965-19967	IN	denotes	in
T3977	19968-19978	NN	denotes	maturation
T3978	19979-19984	EX	denotes	there
T3972	19985-19988	VBP	denotes	are
T3979	19989-19994	RB	denotes	still
T3980	19995-20003	JJ	denotes	numerous
T3982	20004-20010	JJ	denotes	spiral
T3981	20011-20018	NNS	denotes	neurons
T3983	20019-20026	JJ	denotes	present
T3984	20027-20029	IN	denotes	in
T3985	20030-20033	DT	denotes	the
T3986	20034-20038	NN	denotes	apex
T3987	20039-20040	-LRB-	denotes	(
T3989	20040-20044	NN	denotes	Fig.
T3990	20045-20047	NN	denotes	7c
T3991	20047-20048	,	denotes	,
T3988	20048-20050	NN	denotes	7d
T3992	20050-20051	-RRB-	denotes	)
T3993	20051-20052	.	denotes	.
T3994	20052-20238	sentence	denotes	In summary, these tracing data suggest that mature hair cells are not necessary to direct fiber outgrowth and to maintain some fibers at least up to 6 months in the apex of the cochlea.
T3995	20053-20055	IN	denotes	In
T3997	20056-20063	NN	denotes	summary
T3998	20063-20065	,	denotes	,
T3999	20065-20070	DT	denotes	these
T4001	20071-20078	VBG	denotes	tracing
T4000	20079-20083	NNS	denotes	data
T3996	20084-20091	VBP	denotes	suggest
T4002	20092-20096	IN	denotes	that
T4004	20097-20103	JJ	denotes	mature
T4006	20104-20108	NN	denotes	hair
T4005	20109-20114	NNS	denotes	cells
T4003	20115-20118	VBP	denotes	are
T4007	20119-20122	RB	denotes	not
T4008	20123-20132	JJ	denotes	necessary
T4009	20133-20135	TO	denotes	to
T4010	20136-20142	VB	denotes	direct
T4011	20143-20148	NN	denotes	fiber
T4012	20149-20158	NN	denotes	outgrowth
T4013	20159-20162	CC	denotes	and
T4014	20163-20165	TO	denotes	to
T4015	20166-20174	VB	denotes	maintain
T4016	20175-20179	DT	denotes	some
T4017	20180-20186	NNS	denotes	fibers
T4018	20187-20189	RB	denotes	at
T4020	20190-20195	RBS	denotes	least
T4021	20196-20198	RB	denotes	up
T4022	20199-20201	IN	denotes	to
T4019	20202-20203	CD	denotes	6
T4023	20204-20210	NNS	denotes	months
T4024	20211-20213	IN	denotes	in
T4025	20214-20217	DT	denotes	the
T4026	20218-20222	NN	denotes	apex
T4027	20223-20225	IN	denotes	of
T4028	20226-20229	DT	denotes	the
T4029	20230-20237	NN	denotes	cochlea
T4030	20237-20238	.	denotes	.
T4031	20238-20439	sentence	denotes	Importantly, the spatio-temporal loss of innervation does not follow the pattern of loss known from neurotrophin and neurotrophin receptor null mutations as it starts in Brn3c mutant mice after birth.
T4032	20239-20250	RB	denotes	Importantly
T4034	20250-20252	,	denotes	,
T4035	20252-20255	DT	denotes	the
T4037	20256-20262	JJ	denotes	spatio
T4039	20262-20263	HYPH	denotes	-
T4038	20263-20271	JJ	denotes	temporal
T4036	20272-20276	NN	denotes	loss
T4040	20277-20279	IN	denotes	of
T4041	20280-20291	NN	denotes	innervation
T4042	20292-20296	VBZ	denotes	does
T4043	20297-20300	RB	denotes	not
T4033	20301-20307	VB	denotes	follow
T4044	20308-20311	DT	denotes	the
T4045	20312-20319	NN	denotes	pattern
T4046	20320-20322	IN	denotes	of
T4047	20323-20327	NN	denotes	loss
T4048	20328-20333	VBN	denotes	known
T4049	20334-20338	IN	denotes	from
T4050	20339-20351	NN	denotes	neurotrophin
T4052	20352-20355	CC	denotes	and
T4053	20356-20368	NN	denotes	neurotrophin
T4054	20369-20377	NN	denotes	receptor
T4055	20378-20382	JJ	denotes	null
T4051	20383-20392	NNS	denotes	mutations
T4056	20393-20395	IN	denotes	as
T4058	20396-20398	PRP	denotes	it
T4057	20399-20405	VBZ	denotes	starts
T4059	20406-20408	IN	denotes	in
T4060	20409-20414	NN	denotes	Brn3c
T4062	20415-20421	JJ	denotes	mutant
T4061	20422-20426	NNS	denotes	mice
T4063	20427-20432	IN	denotes	after
T4064	20433-20438	NN	denotes	birth
T4065	20438-20439	.	denotes	.
T4241	20441-20443	FW	denotes	In
T4242	20444-20448	FW	denotes	situ
T4243	20449-20462	NN	denotes	hybridization
T4244	20463-20471	VBZ	denotes	confirms
T4245	20472-20480	JJ	denotes	neonatal
T4247	20481-20493	NN	denotes	neurotrophin
T4246	20494-20504	NN	denotes	expression
T4248	20504-20654	sentence	denotes	We processed four ears of P0 and P8 Brn3c null and control littermates for expression of BDNF and NT-3 using the riboprobes previously described [7].
T4249	20505-20507	PRP	denotes	We
T4250	20508-20517	VBD	denotes	processed
T4251	20518-20522	CD	denotes	four
T4252	20523-20527	NNS	denotes	ears
T4253	20528-20530	IN	denotes	of
T4254	20531-20533	NN	denotes	P0
T4256	20534-20537	CC	denotes	and
T4257	20538-20540	NN	denotes	P8
T4258	20541-20546	NN	denotes	Brn3c
T4259	20547-20551	JJ	denotes	null
T4260	20552-20555	CC	denotes	and
T4261	20556-20563	NN	denotes	control
T4255	20564-20575	NNS	denotes	littermates
T4262	20576-20579	IN	denotes	for
T4263	20580-20590	NN	denotes	expression
T4264	20591-20593	IN	denotes	of
T4265	20594-20598	NN	denotes	BDNF
T4266	20599-20602	CC	denotes	and
T4267	20603-20605	NN	denotes	NT
T4268	20605-20606	HYPH	denotes	-
T4269	20606-20607	CD	denotes	3
T4270	20608-20613	VBG	denotes	using
T4271	20614-20617	DT	denotes	the
T4272	20618-20628	NNS	denotes	riboprobes
T4273	20629-20639	RB	denotes	previously
T4274	20640-20649	VBN	denotes	described
T4275	20650-20651	-LRB-	denotes	[
T4276	20651-20652	CD	denotes	7
T4277	20652-20653	-RRB-	denotes	]
T4278	20653-20654	.	denotes	.
T4279	20654-20831	sentence	denotes	We did not analyze neurotrophin expression in 6-month old animals as neurotrophins are downregulated in neonates [20] and no expression can be found even in normal animals [4].
T4280	20655-20657	PRP	denotes	We
T4282	20658-20661	VBD	denotes	did
T4283	20662-20665	RB	denotes	not
T4281	20666-20673	VB	denotes	analyze
T4284	20674-20686	NN	denotes	neurotrophin
T4285	20687-20697	NN	denotes	expression
T4286	20698-20700	IN	denotes	in
T4287	20701-20702	JJ	denotes	6
T4289	20702-20703	HYPH	denotes	-
T4288	20703-20708	JJ	denotes	month
T4290	20709-20712	JJ	denotes	old
T4291	20713-20720	NNS	denotes	animals
T4292	20721-20723	IN	denotes	as
T4294	20724-20737	NNS	denotes	neurotrophins
T4295	20738-20741	VBP	denotes	are
T4293	20742-20755	VBN	denotes	downregulated
T4296	20756-20758	IN	denotes	in
T4297	20759-20767	NNS	denotes	neonates
T4298	20768-20769	-LRB-	denotes	[
T4299	20769-20771	CD	denotes	20
T4300	20771-20772	-RRB-	denotes	]
T4301	20773-20776	CC	denotes	and
T4302	20777-20779	DT	denotes	no
T4303	20780-20790	NN	denotes	expression
T4305	20791-20794	MD	denotes	can
T4306	20795-20797	VB	denotes	be
T4304	20798-20803	VBN	denotes	found
T4307	20804-20808	RB	denotes	even
T4308	20809-20811	IN	denotes	in
T4309	20812-20818	JJ	denotes	normal
T4310	20819-20826	NNS	denotes	animals
T4311	20827-20828	-LRB-	denotes	[
T4312	20828-20829	CD	denotes	4
T4313	20829-20830	-RRB-	denotes	]
T4314	20830-20831	.	denotes	.
T4315	20831-20896	sentence	denotes	In the canal cristae we expected, and found, only a BDNF signal.
T4316	20832-20834	IN	denotes	In
T4318	20835-20838	DT	denotes	the
T4320	20839-20844	NN	denotes	canal
T4319	20845-20852	NNS	denotes	cristae
T4321	20853-20855	PRP	denotes	we
T4317	20856-20864	VBD	denotes	expected
T4322	20864-20866	,	denotes	,
T4323	20866-20869	CC	denotes	and
T4324	20870-20875	VBD	denotes	found
T4325	20875-20877	,	denotes	,
T4326	20877-20881	RB	denotes	only
T4328	20882-20883	DT	denotes	a
T4329	20884-20888	NN	denotes	BDNF
T4327	20889-20895	NN	denotes	signal
T4330	20895-20896	.	denotes	.
T4331	20896-20977	sentence	denotes	This signal was very strong over hair cells of the P0 control animals (Fig. 8b).
T4332	20897-20901	DT	denotes	This
T4333	20902-20908	NN	denotes	signal
T4334	20909-20912	VBD	denotes	was
T4335	20913-20917	RB	denotes	very
T4336	20918-20924	JJ	denotes	strong
T4337	20925-20929	IN	denotes	over
T4338	20930-20934	NN	denotes	hair
T4339	20935-20940	NNS	denotes	cells
T4340	20941-20943	IN	denotes	of
T4341	20944-20947	DT	denotes	the
T4343	20948-20950	NN	denotes	P0
T4344	20951-20958	NN	denotes	control
T4342	20959-20966	NNS	denotes	animals
T4345	20967-20968	-LRB-	denotes	(
T4347	20968-20972	NN	denotes	Fig.
T4346	20973-20975	NN	denotes	8b
T4348	20975-20976	-RRB-	denotes	)
T4349	20976-20977	.	denotes	.
T4350	20977-21153	sentence	denotes	In contrast, only a faint signal was detected in the Brn3c null mutant (Fig. 8a) and the few silver grains were located predominantly over the area of the immature hair cells.
T4351	20978-20980	IN	denotes	In
T4353	20981-20989	NN	denotes	contrast
T4354	20989-20991	,	denotes	,
T4355	20991-20995	RB	denotes	only
T4357	20996-20997	DT	denotes	a
T4358	20998-21003	JJ	denotes	faint
T4356	21004-21010	NN	denotes	signal
T4359	21011-21014	VBD	denotes	was
T4352	21015-21023	VBN	denotes	detected
T4360	21024-21026	IN	denotes	in
T4361	21027-21030	DT	denotes	the
T4363	21031-21036	NN	denotes	Brn3c
T4364	21037-21041	JJ	denotes	null
T4362	21042-21048	NN	denotes	mutant
T4365	21049-21050	-LRB-	denotes	(
T4367	21050-21054	NN	denotes	Fig.
T4366	21055-21057	NN	denotes	8a
T4368	21057-21058	-RRB-	denotes	)
T4369	21059-21062	CC	denotes	and
T4370	21063-21066	DT	denotes	the
T4372	21067-21070	JJ	denotes	few
T4373	21071-21077	JJ	denotes	silver
T4371	21078-21084	NNS	denotes	grains
T4375	21085-21089	VBD	denotes	were
T4374	21090-21097	VBN	denotes	located
T4376	21098-21111	RB	denotes	predominantly
T4377	21112-21116	IN	denotes	over
T4378	21117-21120	DT	denotes	the
T4379	21121-21125	NN	denotes	area
T4380	21126-21128	IN	denotes	of
T4381	21129-21132	DT	denotes	the
T4383	21133-21141	JJ	denotes	immature
T4384	21142-21146	NN	denotes	hair
T4382	21147-21152	NNS	denotes	cells
T4385	21152-21153	.	denotes	.
T4386	21153-21341	sentence	denotes	The BDNF signal in the utricle was clearly centered on the hair cells in the control animal but some aggregation of silver grains appeared also in the Brn3c null mutants (data not shown).
T4387	21154-21157	DT	denotes	The
T4389	21158-21162	NN	denotes	BDNF
T4388	21163-21169	NN	denotes	signal
T4391	21170-21172	IN	denotes	in
T4392	21173-21176	DT	denotes	the
T4393	21177-21184	NN	denotes	utricle
T4394	21185-21188	VBD	denotes	was
T4395	21189-21196	RB	denotes	clearly
T4390	21197-21205	VBN	denotes	centered
T4396	21206-21208	IN	denotes	on
T4397	21209-21212	DT	denotes	the
T4399	21213-21217	NN	denotes	hair
T4398	21218-21223	NNS	denotes	cells
T4400	21224-21226	IN	denotes	in
T4401	21227-21230	DT	denotes	the
T4403	21231-21238	NN	denotes	control
T4402	21239-21245	NN	denotes	animal
T4404	21246-21249	CC	denotes	but
T4405	21250-21254	DT	denotes	some
T4406	21255-21266	NN	denotes	aggregation
T4408	21267-21269	IN	denotes	of
T4409	21270-21276	NN	denotes	silver
T4410	21277-21283	NNS	denotes	grains
T4407	21284-21292	VBD	denotes	appeared
T4411	21293-21297	RB	denotes	also
T4412	21298-21300	IN	denotes	in
T4413	21301-21304	DT	denotes	the
T4415	21305-21310	NN	denotes	Brn3c
T4416	21311-21315	JJ	denotes	null
T4414	21316-21323	NNS	denotes	mutants
T4417	21324-21325	-LRB-	denotes	(
T4419	21325-21329	NNS	denotes	data
T4420	21330-21333	RB	denotes	not
T4418	21334-21339	VBN	denotes	shown
T4421	21339-21340	-RRB-	denotes	)
T4422	21340-21341	.	denotes	.
T4423	21341-21342	sentence	denotes
T10148	21352-21355	DT	denotes	The
T10149	21356-21366	NN	denotes	expression
T10151	21367-21369	IN	denotes	of
T10152	21370-21374	NN	denotes	BDNF
T10154	21375-21378	CC	denotes	and
T10155	21379-21381	NN	denotes	NT
T10156	21381-21382	HYPH	denotes	-
T10157	21382-21383	CD	denotes	3
T10153	21384-21388	NN	denotes	mRNA
T10158	21389-21391	VBZ	denotes	is
T10150	21392-21397	VBN	denotes	shown
T10159	21398-21400	IN	denotes	in
T10160	21401-21404	DT	denotes	the
T10162	21405-21407	NN	denotes	P0
T10163	21408-21418	JJ	denotes	vestibular
T10164	21419-21426	JJ	denotes	sensory
T10161	21427-21436	NNS	denotes	epithelia
T10165	21436-21437	.	denotes	.
T10166	21437-21541	sentence	denotes	Silver grains are false colored as red to enhance visibility against the grey Nissl-stained background.
T10167	21438-21444	NN	denotes	Silver
T10168	21445-21451	NNS	denotes	grains
T10170	21452-21455	VBP	denotes	are
T10171	21456-21461	JJ	denotes	false
T10169	21462-21469	VBN	denotes	colored
T10172	21470-21472	IN	denotes	as
T10173	21473-21476	NN	denotes	red
T10174	21477-21479	TO	denotes	to
T10175	21480-21487	VB	denotes	enhance
T10176	21488-21498	NN	denotes	visibility
T10177	21499-21506	IN	denotes	against
T10178	21507-21510	DT	denotes	the
T10180	21511-21515	JJ	denotes	grey
T10181	21516-21521	NNP	denotes	Nissl
T10183	21521-21522	HYPH	denotes	-
T10182	21522-21529	VBN	denotes	stained
T10179	21530-21540	NN	denotes	background
T10184	21540-21541	.	denotes	.
T10185	21541-21670	sentence	denotes	Canal cristae contain only BDNF (a,b), but gravistatic endorgans, such as saccule and utricle, contain both BDNF and NT-3 (c-f).
T10186	21542-21547	JJ	denotes	Canal
T10187	21548-21555	NNS	denotes	cristae
T10188	21556-21563	VBP	denotes	contain
T10189	21564-21568	RB	denotes	only
T10190	21569-21573	NN	denotes	BDNF
T10191	21574-21575	-LRB-	denotes	(
T10193	21575-21576	NN	denotes	a
T10194	21576-21577	,	denotes	,
T10192	21577-21578	NN	denotes	b
T10195	21578-21579	-RRB-	denotes	)
T10196	21579-21581	,	denotes	,
T10197	21581-21584	CC	denotes	but
T10198	21585-21596	JJ	denotes	gravistatic
T10199	21597-21606	NNS	denotes	endorgans
T10201	21606-21608	,	denotes	,
T10202	21608-21612	JJ	denotes	such
T10203	21613-21615	IN	denotes	as
T10204	21616-21623	NN	denotes	saccule
T10205	21624-21627	CC	denotes	and
T10206	21628-21635	NN	denotes	utricle
T10207	21635-21637	,	denotes	,
T10200	21637-21644	VBP	denotes	contain
T10208	21645-21649	CC	denotes	both
T10209	21650-21654	NN	denotes	BDNF
T10210	21655-21658	CC	denotes	and
T10211	21659-21661	NN	denotes	NT
T10212	21661-21662	HYPH	denotes	-
T10213	21662-21663	CD	denotes	3
T10214	21664-21665	-LRB-	denotes	(
T10215	21665-21666	NN	denotes	c
T10216	21666-21667	SYM	denotes	-
T10217	21667-21668	NN	denotes	f
T10218	21668-21669	-RRB-	denotes	)
T10219	21669-21670	.	denotes	.
T10220	21670-21862	sentence	denotes	Note the prominent BDNF expression in the hair cell region (HaC) of control canal (b) and saccule (d) and low levels of expression in the Brn3c null mice (a,c) over immature hair cells (iHC).
T10221	21671-21675	VB	denotes	Note
T10222	21676-21679	DT	denotes	the
T10224	21680-21689	JJ	denotes	prominent
T10225	21690-21694	NN	denotes	BDNF
T10223	21695-21705	NN	denotes	expression
T10226	21706-21708	IN	denotes	in
T10227	21709-21712	DT	denotes	the
T10229	21713-21717	NN	denotes	hair
T10230	21718-21722	NN	denotes	cell
T10228	21723-21729	NN	denotes	region
T10231	21730-21731	-LRB-	denotes	(
T10232	21731-21734	NN	denotes	HaC
T10233	21734-21735	-RRB-	denotes	)
T10234	21736-21738	IN	denotes	of
T10235	21739-21746	NN	denotes	control
T10236	21747-21752	NN	denotes	canal
T10237	21753-21754	-LRB-	denotes	(
T10238	21754-21755	NN	denotes	b
T10239	21755-21756	-RRB-	denotes	)
T10240	21757-21760	CC	denotes	and
T10241	21761-21768	NN	denotes	saccule
T10242	21769-21770	-LRB-	denotes	(
T10243	21770-21771	NN	denotes	d
T10244	21771-21772	-RRB-	denotes	)
T10245	21773-21776	CC	denotes	and
T10246	21777-21780	JJ	denotes	low
T10247	21781-21787	NNS	denotes	levels
T10248	21788-21790	IN	denotes	of
T10249	21791-21801	NN	denotes	expression
T10250	21802-21804	IN	denotes	in
T10251	21805-21808	DT	denotes	the
T10253	21809-21814	NN	denotes	Brn3c
T10254	21815-21819	JJ	denotes	null
T10252	21820-21824	NNS	denotes	mice
T10255	21825-21826	-LRB-	denotes	(
T10257	21826-21827	NN	denotes	a
T10258	21827-21828	,	denotes	,
T10256	21828-21829	NN	denotes	c
T10259	21829-21830	-RRB-	denotes	)
T10260	21831-21835	IN	denotes	over
T10261	21836-21844	JJ	denotes	immature
T10263	21845-21849	NN	denotes	hair
T10262	21850-21855	NNS	denotes	cells
T10264	21856-21857	-LRB-	denotes	(
T10265	21857-21860	NN	denotes	iHC
T10266	21860-21861	-RRB-	denotes	)
T10267	21861-21862	.	denotes	.
T10268	21862-21949	sentence	denotes	The NT-3 expression is much more diffuse in both control and Brn3c mutant littermates.
T10269	21863-21866	DT	denotes	The
T10271	21867-21869	NN	denotes	NT
T10272	21869-21870	HYPH	denotes	-
T10273	21870-21871	CD	denotes	3
T10270	21872-21882	NN	denotes	expression
T10274	21883-21885	VBZ	denotes	is
T10275	21886-21890	RB	denotes	much
T10277	21891-21895	RBR	denotes	more
T10276	21896-21903	JJ	denotes	diffuse
T10278	21904-21906	IN	denotes	in
T10279	21907-21911	CC	denotes	both
T10280	21912-21919	NN	denotes	control
T10282	21920-21923	CC	denotes	and
T10283	21924-21929	NN	denotes	Brn3c
T10284	21930-21936	JJ	denotes	mutant
T10281	21937-21948	NNS	denotes	littermates
T10285	21948-21949	.	denotes	.
T10286	21949-21971	sentence	denotes	Bar indicates 100 μm.
T10287	21950-21953	NNP	denotes	Bar
T10288	21954-21963	VBZ	denotes	indicates
T10289	21964-21967	CD	denotes	100
T10290	21968-21970	NNS	denotes	μm
T10291	21970-21971	.	denotes	.
T4425	21972-21974	IN	denotes	In
T4424	21972-22135	sentence	denotes	In the saccule, we directly compared the BDNF (Fig. 8c,8d) and NT-3 signal (Fig. 8e,8f) of the Brn3c null mutant (Fig. 8c,8e) and control littermates (Fig. 8d,8f).
T4427	21975-21978	DT	denotes	the
T4428	21979-21986	NN	denotes	saccule
T4429	21986-21988	,	denotes	,
T4430	21988-21990	PRP	denotes	we
T4431	21991-21999	RB	denotes	directly
T4426	22000-22008	VBD	denotes	compared
T4432	22009-22012	DT	denotes	the
T4434	22013-22017	NN	denotes	BDNF
T4435	22018-22019	-LRB-	denotes	(
T4437	22019-22023	NN	denotes	Fig.
T4438	22024-22026	NN	denotes	8c
T4439	22026-22027	,	denotes	,
T4436	22027-22029	NN	denotes	8d
T4440	22029-22030	-RRB-	denotes	)
T4441	22031-22034	CC	denotes	and
T4442	22035-22037	NN	denotes	NT
T4443	22037-22038	HYPH	denotes	-
T4444	22038-22039	CD	denotes	3
T4433	22040-22046	NN	denotes	signal
T4445	22047-22048	-LRB-	denotes	(
T4447	22048-22052	NN	denotes	Fig.
T4448	22053-22055	NN	denotes	8e
T4449	22055-22056	,	denotes	,
T4446	22056-22058	NN	denotes	8f
T4450	22058-22059	-RRB-	denotes	)
T4451	22060-22062	IN	denotes	of
T4452	22063-22066	DT	denotes	the
T4454	22067-22072	NN	denotes	Brn3c
T4455	22073-22077	JJ	denotes	null
T4453	22078-22084	NN	denotes	mutant
T4456	22085-22086	-LRB-	denotes	(
T4458	22086-22090	NN	denotes	Fig.
T4459	22091-22093	NN	denotes	8c
T4460	22093-22094	,	denotes	,
T4457	22094-22096	NN	denotes	8e
T4461	22096-22097	-RRB-	denotes	)
T4462	22098-22101	CC	denotes	and
T4463	22102-22109	NN	denotes	control
T4464	22110-22121	NNS	denotes	littermates
T4465	22122-22123	-LRB-	denotes	(
T4467	22123-22127	NNP	denotes	Fig.
T4468	22128-22130	CD	denotes	8d
T4469	22130-22131	,	denotes	,
T4466	22131-22133	CD	denotes	8f
T4470	22133-22134	-RRB-	denotes	)
T4471	22134-22135	.	denotes	.
T4472	22135-22295	sentence	denotes	A strong BDNF signal was found over the hair cells of control animals and an occasional immature hair cell also showed a BDNF signal in the Brn3c null mutants.
T4473	22136-22137	DT	denotes	A
T4475	22138-22144	JJ	denotes	strong
T4476	22145-22149	NN	denotes	BDNF
T4474	22150-22156	NN	denotes	signal
T4478	22157-22160	VBD	denotes	was
T4477	22161-22166	VBN	denotes	found
T4479	22167-22171	IN	denotes	over
T4480	22172-22175	DT	denotes	the
T4482	22176-22180	NN	denotes	hair
T4481	22181-22186	NNS	denotes	cells
T4483	22187-22189	IN	denotes	of
T4484	22190-22197	NN	denotes	control
T4485	22198-22205	NNS	denotes	animals
T4486	22206-22209	CC	denotes	and
T4487	22210-22212	DT	denotes	an
T4489	22213-22223	JJ	denotes	occasional
T4490	22224-22232	JJ	denotes	immature
T4491	22233-22237	NN	denotes	hair
T4488	22238-22242	NN	denotes	cell
T4493	22243-22247	RB	denotes	also
T4492	22248-22254	VBD	denotes	showed
T4494	22255-22256	DT	denotes	a
T4496	22257-22261	NN	denotes	BDNF
T4495	22262-22268	NN	denotes	signal
T4497	22269-22271	IN	denotes	in
T4498	22272-22275	DT	denotes	the
T4500	22276-22281	NN	denotes	Brn3c
T4501	22282-22286	JJ	denotes	null
T4499	22287-22294	NNS	denotes	mutants
T4502	22294-22295	.	denotes	.
T4503	22295-22497	sentence	denotes	The NT-3 signal was more diffuse in both the control and the Brn3c null littermates but showed some slightly above background signal in the area of the sensory epithelium even in the Brn3c null mutant.
T4504	22296-22299	DT	denotes	The
T4506	22300-22302	NN	denotes	NT
T4507	22302-22303	HYPH	denotes	-
T4508	22303-22304	CD	denotes	3
T4505	22305-22311	NN	denotes	signal
T4509	22312-22315	VBD	denotes	was
T4510	22316-22320	RBR	denotes	more
T4511	22321-22328	JJ	denotes	diffuse
T4512	22329-22331	IN	denotes	in
T4513	22332-22336	CC	denotes	both
T4515	22337-22340	DT	denotes	the
T4514	22341-22348	NN	denotes	control
T4516	22349-22352	CC	denotes	and
T4517	22353-22356	DT	denotes	the
T4519	22357-22362	NN	denotes	Brn3c
T4518	22363-22367	JJ	denotes	null
T4520	22368-22379	NNS	denotes	littermates
T4521	22380-22383	CC	denotes	but
T4522	22384-22390	VBD	denotes	showed
T4523	22391-22395	DT	denotes	some
T4525	22396-22404	RB	denotes	slightly
T4526	22405-22410	JJ	denotes	above
T4527	22411-22421	NN	denotes	background
T4524	22422-22428	NN	denotes	signal
T4528	22429-22431	IN	denotes	in
T4529	22432-22435	DT	denotes	the
T4530	22436-22440	NN	denotes	area
T4531	22441-22443	IN	denotes	of
T4532	22444-22447	DT	denotes	the
T4534	22448-22455	JJ	denotes	sensory
T4533	22456-22466	NN	denotes	epithelium
T4535	22467-22471	RB	denotes	even
T4536	22472-22474	IN	denotes	in
T4537	22475-22478	DT	denotes	the
T4539	22479-22484	NN	denotes	Brn3c
T4540	22485-22489	JJ	denotes	null
T4538	22490-22496	NN	denotes	mutant
T4541	22496-22497	.	denotes	.
T4542	22497-22627	sentence	denotes	In the cochlea, the BDNF signal was very weak in the base in both the control (Fig. 9b) and the Brn3c null littermates (Fig. 9a).
T4543	22498-22500	IN	denotes	In
T4545	22501-22504	DT	denotes	the
T4546	22505-22512	NN	denotes	cochlea
T4547	22512-22514	,	denotes	,
T4548	22514-22517	DT	denotes	the
T4550	22518-22522	NN	denotes	BDNF
T4549	22523-22529	NN	denotes	signal
T4544	22530-22533	VBD	denotes	was
T4551	22534-22538	RB	denotes	very
T4552	22539-22543	JJ	denotes	weak
T4553	22544-22546	IN	denotes	in
T4554	22547-22550	DT	denotes	the
T4555	22551-22555	NN	denotes	base
T4556	22556-22558	IN	denotes	in
T4557	22559-22563	CC	denotes	both
T4559	22564-22567	DT	denotes	the
T4558	22568-22575	NN	denotes	control
T4560	22576-22577	-LRB-	denotes	(
T4562	22577-22581	NN	denotes	Fig.
T4561	22582-22584	NN	denotes	9b
T4563	22584-22585	-RRB-	denotes	)
T4564	22586-22589	CC	denotes	and
T4565	22590-22593	DT	denotes	the
T4566	22594-22599	NN	denotes	Brn3c
T4568	22600-22604	JJ	denotes	null
T4567	22605-22616	NNS	denotes	littermates
T4569	22617-22618	-LRB-	denotes	(
T4571	22618-22622	NNP	denotes	Fig.
T4570	22623-22625	NNP	denotes	9a
T4572	22625-22626	-RRB-	denotes	)
T4573	22626-22627	.	denotes	.
T4574	22627-22828	sentence	denotes	However, there was a surprisingly strong NT-3 signal over the organ of Corti in the apex of Brn3c null littermates (Fig. 9c) that closely matched the signal found in the control littermates (Fig. 9d).
T4575	22628-22635	RB	denotes	However
T4577	22635-22637	,	denotes	,
T4578	22637-22642	EX	denotes	there
T4576	22643-22646	VBD	denotes	was
T4579	22647-22648	DT	denotes	a
T4581	22649-22661	RB	denotes	surprisingly
T4582	22662-22668	JJ	denotes	strong
T4583	22669-22671	NN	denotes	NT
T4584	22671-22672	HYPH	denotes	-
T4585	22672-22673	CD	denotes	3
T4580	22674-22680	NN	denotes	signal
T4586	22681-22685	IN	denotes	over
T4587	22686-22689	DT	denotes	the
T4588	22690-22695	NN	denotes	organ
T4589	22696-22698	IN	denotes	of
T4590	22699-22704	NNP	denotes	Corti
T4591	22705-22707	IN	denotes	in
T4592	22708-22711	DT	denotes	the
T4593	22712-22716	NN	denotes	apex
T4594	22717-22719	IN	denotes	of
T4595	22720-22725	NN	denotes	Brn3c
T4597	22726-22730	JJ	denotes	null
T4596	22731-22742	NNS	denotes	littermates
T4598	22743-22744	-LRB-	denotes	(
T4600	22744-22748	NNP	denotes	Fig.
T4599	22749-22751	NNP	denotes	9c
T4601	22751-22752	-RRB-	denotes	)
T4602	22753-22757	WDT	denotes	that
T4604	22758-22765	RB	denotes	closely
T4603	22766-22773	VBD	denotes	matched
T4605	22774-22777	DT	denotes	the
T4606	22778-22784	NN	denotes	signal
T4607	22785-22790	VBN	denotes	found
T4608	22791-22793	IN	denotes	in
T4609	22794-22797	DT	denotes	the
T4611	22798-22805	NN	denotes	control
T4610	22806-22817	NNS	denotes	littermates
T4612	22818-22819	-LRB-	denotes	(
T4613	22819-22823	NN	denotes	Fig.
T4614	22824-22826	CD	denotes	9d
T4615	22826-22827	-RRB-	denotes	)
T4616	22827-22828	.	denotes	.
T4617	22828-22974	sentence	denotes	The NT-3 signal in the area of the cochlea that corresponds to the IHC's persisted at least until P8 in the apex of Brn3c null mice (Fig. 9e,9f).
T4618	22829-22832	DT	denotes	The
T4620	22833-22835	NN	denotes	NT
T4621	22835-22836	HYPH	denotes	-
T4622	22836-22837	CD	denotes	3
T4619	22838-22844	NN	denotes	signal
T4624	22845-22847	IN	denotes	in
T4625	22848-22851	DT	denotes	the
T4626	22852-22856	NN	denotes	area
T4627	22857-22859	IN	denotes	of
T4628	22860-22863	DT	denotes	the
T4629	22864-22871	NN	denotes	cochlea
T4630	22872-22876	WDT	denotes	that
T4631	22877-22888	VBZ	denotes	corresponds
T4632	22889-22891	IN	denotes	to
T4633	22892-22895	DT	denotes	the
T4634	22896-22899	NNP	denotes	IHC
T4635	22899-22901	POS	denotes	's
T4623	22902-22911	VBD	denotes	persisted
T4636	22912-22914	RB	denotes	at
T4637	22915-22920	RBS	denotes	least
T4638	22921-22926	IN	denotes	until
T4639	22927-22929	NN	denotes	P8
T4640	22930-22932	IN	denotes	in
T4641	22933-22936	DT	denotes	the
T4642	22937-22941	NN	denotes	apex
T4643	22942-22944	IN	denotes	of
T4644	22945-22950	NN	denotes	Brn3c
T4646	22951-22955	JJ	denotes	null
T4645	22956-22960	NNS	denotes	mice
T4647	22961-22962	-LRB-	denotes	(
T4649	22962-22966	NN	denotes	Fig.
T4650	22967-22969	CD	denotes	9e
T4651	22969-22970	,	denotes	,
T4648	22970-22972	CD	denotes	9f
T4652	22972-22973	-RRB-	denotes	)
T4653	22973-22974	.	denotes	.
T10350	22985-22989	NN	denotes	BDNF
T10352	22990-22993	CC	denotes	and
T10353	22994-22996	NN	denotes	NT
T10354	22996-22997	HYPH	denotes	-
T10355	22997-22998	CD	denotes	3
T10356	22999-23003	NN	denotes	mRNA
T10351	23004-23014	NN	denotes	expression
T10358	23015-23017	VBZ	denotes	is
T10357	23018-23023	VBN	denotes	shown
T10359	23024-23026	IN	denotes	in
T10360	23027-23030	DT	denotes	the
T10361	23031-23038	NN	denotes	cochlea
T10362	23039-23041	IN	denotes	of
T10363	23042-23044	NN	denotes	P0
T10365	23045-23046	-LRB-	denotes	(
T10366	23046-23047	NN	denotes	a
T10367	23047-23048	SYM	denotes	-
T10368	23048-23049	NN	denotes	d
T10369	23049-23050	-RRB-	denotes	)
T10370	23051-23054	CC	denotes	and
T10371	23055-23057	NN	denotes	P8
T10372	23058-23059	-LRB-	denotes	(
T10374	23059-23060	NN	denotes	e
T10375	23060-23061	,	denotes	,
T10373	23061-23062	NN	denotes	f
T10376	23062-23063	-RRB-	denotes	)
T10377	23064-23069	NN	denotes	Brn3c
T10378	23070-23074	JJ	denotes	null
T10379	23075-23078	CC	denotes	and
T10380	23079-23086	NN	denotes	control
T10364	23087-23098	NNS	denotes	littermates
T10381	23098-23099	.	denotes	.
T10382	23099-23340	sentence	denotes	Note the limited expression of BDNF in the basal turn of both wildtype and mutant littermates (a,b) and the much stronger expression of NT-3 in the apex over the region of the inner hair cells in both wildtype and control littermates (c,d).
T10383	23100-23104	VB	denotes	Note
T10384	23105-23108	DT	denotes	the
T10386	23109-23116	VBN	denotes	limited
T10385	23117-23127	NN	denotes	expression
T10387	23128-23130	IN	denotes	of
T10388	23131-23135	NN	denotes	BDNF
T10389	23136-23138	IN	denotes	in
T10390	23139-23142	DT	denotes	the
T10392	23143-23148	JJ	denotes	basal
T10391	23149-23153	NN	denotes	turn
T10393	23154-23156	IN	denotes	of
T10394	23157-23161	CC	denotes	both
T10395	23162-23170	JJ	denotes	wildtype
T10397	23171-23174	CC	denotes	and
T10398	23175-23181	JJ	denotes	mutant
T10396	23182-23193	NNS	denotes	littermates
T10399	23194-23195	-LRB-	denotes	(
T10401	23195-23196	NN	denotes	a
T10402	23196-23197	,	denotes	,
T10400	23197-23198	NN	denotes	b
T10403	23198-23199	-RRB-	denotes	)
T10404	23200-23203	CC	denotes	and
T10405	23204-23207	DT	denotes	the
T10407	23208-23212	RB	denotes	much
T10408	23213-23221	JJR	denotes	stronger
T10406	23222-23232	NN	denotes	expression
T10409	23233-23235	IN	denotes	of
T10410	23236-23238	NN	denotes	NT
T10411	23238-23239	HYPH	denotes	-
T10412	23239-23240	CD	denotes	3
T10413	23241-23243	IN	denotes	in
T10414	23244-23247	DT	denotes	the
T10415	23248-23252	NN	denotes	apex
T10416	23253-23257	IN	denotes	over
T10417	23258-23261	DT	denotes	the
T10418	23262-23268	NN	denotes	region
T10419	23269-23271	IN	denotes	of
T10420	23272-23275	DT	denotes	the
T10422	23276-23281	JJ	denotes	inner
T10423	23282-23286	NN	denotes	hair
T10421	23287-23292	NNS	denotes	cells
T10424	23293-23295	IN	denotes	in
T10425	23296-23300	CC	denotes	both
T10426	23301-23309	NN	denotes	wildtype
T10428	23310-23313	CC	denotes	and
T10429	23314-23321	NN	denotes	control
T10427	23322-23333	NNS	denotes	littermates
T10430	23334-23335	-LRB-	denotes	(
T10432	23335-23336	NN	denotes	c
T10433	23336-23337	,	denotes	,
T10431	23337-23338	NN	denotes	d
T10434	23338-23339	-RRB-	denotes	)
T10435	23339-23340	.	denotes	.
T10436	23340-23511	sentence	denotes	NT-3 expression persists at least until P8 in the apex of Brn3c null mice in an area that topologically compares to the inner hair cells of control animals (e,f, arrows).
T10437	23341-23343	NN	denotes	NT
T10439	23343-23344	HYPH	denotes	-
T10440	23344-23345	CD	denotes	3
T10438	23346-23356	NN	denotes	expression
T10441	23357-23365	VBZ	denotes	persists
T10442	23366-23368	RB	denotes	at
T10443	23369-23374	RBS	denotes	least
T10444	23375-23380	IN	denotes	until
T10445	23381-23383	NN	denotes	P8
T10446	23384-23386	IN	denotes	in
T10447	23387-23390	DT	denotes	the
T10448	23391-23395	NN	denotes	apex
T10449	23396-23398	IN	denotes	of
T10450	23399-23404	NN	denotes	Brn3c
T10451	23405-23409	JJ	denotes	null
T10452	23410-23414	NNS	denotes	mice
T10453	23415-23417	IN	denotes	in
T10454	23418-23420	DT	denotes	an
T10455	23421-23425	NN	denotes	area
T10456	23426-23430	WDT	denotes	that
T10458	23431-23444	RB	denotes	topologically
T10457	23445-23453	VBZ	denotes	compares
T10459	23454-23456	IN	denotes	to
T10460	23457-23460	DT	denotes	the
T10462	23461-23466	JJ	denotes	inner
T10463	23467-23471	NN	denotes	hair
T10461	23472-23477	NNS	denotes	cells
T10464	23478-23480	IN	denotes	of
T10465	23481-23488	NN	denotes	control
T10466	23489-23496	NNS	denotes	animals
T10467	23497-23498	-LRB-	denotes	(
T10469	23498-23499	NN	denotes	e
T10471	23499-23500	,	denotes	,
T10470	23500-23501	NN	denotes	f
T10472	23501-23503	,	denotes	,
T10468	23503-23509	NNS	denotes	arrows
T10473	23509-23510	-RRB-	denotes	)
T10474	23510-23511	.	denotes	.
T10475	23511-23533	sentence	denotes	Bar indicates 100 μm.
T10476	23512-23515	NNP	denotes	Bar
T10477	23516-23525	VBZ	denotes	indicates
T10478	23526-23529	CD	denotes	100
T10479	23530-23532	NNS	denotes	μm
T10480	23532-23533	.	denotes	.
T4693	23546-23548	PRP	denotes	We
T4695	23549-23553	MD	denotes	will
T4694	23554-23561	VB	denotes	explore
T4696	23562-23566	CD	denotes	five
T4697	23567-23573	NNS	denotes	points
T4698	23574-23576	IN	denotes	in
T4699	23577-23581	DT	denotes	this
T4700	23582-23592	NN	denotes	discussion
T4701	23592-23594	:	denotes	:
T4702	23594-23597	WRB	denotes	How
T4704	23598-23601	DT	denotes	the
T4706	23602-23609	VBN	denotes	limited
T4705	23610-23620	NN	denotes	expression
T4707	23621-23623	IN	denotes	of
T4708	23624-23637	NNS	denotes	neurotrophins
T4703	23638-23645	VBZ	denotes	relates
T4709	23646-23648	IN	denotes	to
T4710	23649-23652	DT	denotes	the
T4712	23653-23661	JJ	denotes	apparent
T4711	23662-23670	NN	denotes	survival
T4713	23671-23673	IN	denotes	of
T4714	23674-23681	JJ	denotes	primary
T4715	23682-23689	NNS	denotes	neurons
T4716	23690-23695	IN	denotes	until
T4717	23696-23698	NN	denotes	P8
T4718	23698-23699	:	denotes	;
T4719	23700-23703	WRB	denotes	how
T4721	23704-23707	DT	denotes	the
T4723	23708-23713	VBN	denotes	known
T4722	23714-23721	NN	denotes	absence
T4724	23722-23724	IN	denotes	of
T4725	23725-23731	JJ	denotes	apical
T4727	23732-23736	NN	denotes	hair
T4726	23737-23742	NNS	denotes	cells
T4728	23743-23746	CC	denotes	and
T4729	23747-23749	IN	denotes	of
T4730	23750-23759	JJ	denotes	classical
T4731	23760-23773	NNS	denotes	neurotrophins
T4732	23774-23777	MD	denotes	can
T4720	23778-23780	VB	denotes	be
T4733	23781-23788	JJ	denotes	related
T4734	23789-23791	IN	denotes	to
T4735	23792-23795	DT	denotes	the
T4736	23796-23804	NN	denotes	presence
T4737	23805-23807	IN	denotes	of
T4738	23808-23813	JJ	denotes	large
T4739	23814-23821	NNS	denotes	numbers
T4740	23822-23824	IN	denotes	of
T4741	23825-23831	JJ	denotes	apical
T4742	23832-23836	NN	denotes	turn
T4744	23837-23843	JJ	denotes	spiral
T4743	23844-23851	NNS	denotes	neurons
T4745	23851-23852	:	denotes	;
T4746	23853-23856	WRB	denotes	how
T4748	23857-23864	NN	denotes	absence
T4749	23865-23867	IN	denotes	of
T4750	23868-23882	VBN	denotes	differentiated
T4752	23883-23887	NN	denotes	hair
T4751	23888-23893	NNS	denotes	cells
T4747	23894-23901	VBZ	denotes	affects
T4753	23902-23910	JJ	denotes	afferent
T4755	23911-23914	CC	denotes	and
T4756	23915-23923	JJ	denotes	efferent
T4754	23924-23933	NN	denotes	targeting
T4757	23933-23934	:	denotes	;
T4758	23935-23938	CC	denotes	and
T4759	23939-23942	WRB	denotes	how
T4761	23943-23948	DT	denotes	these
T4762	23949-23953	NNS	denotes	data
T4763	23954-23962	RB	denotes	possibly
T4760	23963-23969	VB	denotes	relate
T4764	23970-23972	IN	denotes	to
T4765	23973-23978	JJ	denotes	other
T4767	23979-23985	JJ	denotes	mutant
T4766	23986-23993	NNS	denotes	animals
T4768	23994-23997	CC	denotes	and
T4769	23998-24000	IN	denotes	to
T4770	24001-24009	NNS	denotes	children
T4771	24010-24014	VBN	denotes	born
T4772	24015-24019	IN	denotes	with
T4773	24020-24028	JJ	denotes	profound
T4775	24029-24036	NN	denotes	hearing
T4774	24037-24041	NN	denotes	loss
T4776	24041-24042	.	denotes	.
T5075	24044-24052	JJ	denotes	Immature
T5077	24053-24057	NN	denotes	hair
T5076	24058-24063	NNS	denotes	cells
T5079	24064-24067	CC	denotes	and
T5080	24068-24075	JJ	denotes	limited
T5081	24076-24086	NN	denotes	expression
T5082	24087-24089	IN	denotes	of
T5083	24090-24103	NNS	denotes	neurotrophins
T5078	24104-24110	VBP	denotes	rescue
T5084	24111-24119	JJ	denotes	afferent
T5085	24120-24130	NN	denotes	projection
T5086	24131-24136	IN	denotes	until
T5087	24137-24139	NN	denotes	P8
T5088	24139-24232	sentence	denotes	The neurotrophins have long been implicated as the mediators for target mediated cell death.
T5089	24140-24143	DT	denotes	The
T5090	24144-24157	NNS	denotes	neurotrophins
T5092	24158-24162	VBP	denotes	have
T5093	24163-24167	RB	denotes	long
T5094	24168-24172	VBN	denotes	been
T5091	24173-24183	VBN	denotes	implicated
T5095	24184-24186	IN	denotes	as
T5096	24187-24190	DT	denotes	the
T5097	24191-24200	NNS	denotes	mediators
T5098	24201-24204	IN	denotes	for
T5099	24205-24211	NN	denotes	target
T5100	24212-24220	VBN	denotes	mediated
T5102	24221-24225	NN	denotes	cell
T5101	24226-24231	NN	denotes	death
T5103	24231-24232	.	denotes	.
T5104	24232-24528	sentence	denotes	In essence, this theory of regulation of neuronal connections via neurotrophic support implies that only limited quantities of neurotrophins are released by the target tissue to support only properly connected sensory neurons by providing only these with a critical amount of neurotrophins [21].
T5105	24233-24235	IN	denotes	In
T5107	24236-24243	NN	denotes	essence
T5108	24243-24245	,	denotes	,
T5109	24245-24249	DT	denotes	this
T5110	24250-24256	NN	denotes	theory
T5111	24257-24259	IN	denotes	of
T5112	24260-24270	NN	denotes	regulation
T5113	24271-24273	IN	denotes	of
T5114	24274-24282	JJ	denotes	neuronal
T5115	24283-24294	NNS	denotes	connections
T5116	24295-24298	IN	denotes	via
T5117	24299-24311	JJ	denotes	neurotrophic
T5118	24312-24319	NN	denotes	support
T5106	24320-24327	VBZ	denotes	implies
T5119	24328-24332	IN	denotes	that
T5121	24333-24337	RB	denotes	only
T5123	24338-24345	JJ	denotes	limited
T5122	24346-24356	NNS	denotes	quantities
T5124	24357-24359	IN	denotes	of
T5125	24360-24373	NNS	denotes	neurotrophins
T5126	24374-24377	VBP	denotes	are
T5120	24378-24386	VBN	denotes	released
T5127	24387-24389	IN	denotes	by
T5128	24390-24393	DT	denotes	the
T5130	24394-24400	NN	denotes	target
T5129	24401-24407	NN	denotes	tissue
T5131	24408-24410	TO	denotes	to
T5132	24411-24418	VB	denotes	support
T5133	24419-24423	RB	denotes	only
T5135	24424-24432	RB	denotes	properly
T5136	24433-24442	VBN	denotes	connected
T5137	24443-24450	JJ	denotes	sensory
T5134	24451-24458	NNS	denotes	neurons
T5138	24459-24461	IN	denotes	by
T5139	24462-24471	VBG	denotes	providing
T5140	24472-24476	RB	denotes	only
T5141	24477-24482	DT	denotes	these
T5142	24483-24487	IN	denotes	with
T5143	24488-24489	DT	denotes	a
T5145	24490-24498	JJ	denotes	critical
T5144	24499-24505	NN	denotes	amount
T5146	24506-24508	IN	denotes	of
T5147	24509-24522	NNS	denotes	neurotrophins
T5148	24523-24524	-LRB-	denotes	[
T5149	24524-24526	CD	denotes	21
T5150	24526-24527	-RRB-	denotes	]
T5151	24527-24528	.	denotes	.
T5152	24528-24666	sentence	denotes	Past experiments, which eliminated one or more neurotrophins entirely, only partially tested the basic assumption of this theory in vivo.
T5153	24529-24533	NN	denotes	Past
T5154	24534-24545	NNS	denotes	experiments
T5156	24545-24547	,	denotes	,
T5157	24547-24552	WDT	denotes	which
T5158	24553-24563	VBD	denotes	eliminated
T5159	24564-24567	CD	denotes	one
T5161	24568-24570	CC	denotes	or
T5162	24571-24575	JJR	denotes	more
T5160	24576-24589	NNS	denotes	neurotrophins
T5163	24590-24598	RB	denotes	entirely
T5164	24598-24600	,	denotes	,
T5165	24600-24604	RB	denotes	only
T5166	24605-24614	RB	denotes	partially
T5155	24615-24621	VBN	denotes	tested
T5167	24622-24625	DT	denotes	the
T5169	24626-24631	JJ	denotes	basic
T5168	24632-24642	NN	denotes	assumption
T5170	24643-24645	IN	denotes	of
T5171	24646-24650	DT	denotes	this
T5172	24651-24657	NN	denotes	theory
T5173	24658-24660	FW	denotes	in
T5174	24661-24665	FW	denotes	vivo
T5175	24665-24666	.	denotes	.
T5176	24666-24837	sentence	denotes	For example, in BDNF heterozygotic animals there is a small decrease in the number of sensory neurons in the ear [13] but no change in the overall pattern of innervation.
T5177	24667-24670	IN	denotes	For
T5179	24671-24678	NN	denotes	example
T5180	24678-24680	,	denotes	,
T5181	24680-24682	IN	denotes	in
T5182	24683-24687	NN	denotes	BDNF
T5184	24688-24701	JJ	denotes	heterozygotic
T5183	24702-24709	NNS	denotes	animals
T5185	24710-24715	EX	denotes	there
T5178	24716-24718	VBZ	denotes	is
T5186	24719-24720	DT	denotes	a
T5188	24721-24726	JJ	denotes	small
T5187	24727-24735	NN	denotes	decrease
T5189	24736-24738	IN	denotes	in
T5190	24739-24742	DT	denotes	the
T5191	24743-24749	NN	denotes	number
T5192	24750-24752	IN	denotes	of
T5193	24753-24760	JJ	denotes	sensory
T5194	24761-24768	NNS	denotes	neurons
T5195	24769-24771	IN	denotes	in
T5196	24772-24775	DT	denotes	the
T5197	24776-24779	NN	denotes	ear
T5198	24780-24781	-LRB-	denotes	[
T5199	24781-24783	CD	denotes	13
T5200	24783-24784	-RRB-	denotes	]
T5201	24785-24788	CC	denotes	but
T5202	24789-24791	DT	denotes	no
T5203	24792-24798	NN	denotes	change
T5204	24799-24801	IN	denotes	in
T5205	24802-24805	DT	denotes	the
T5207	24806-24813	JJ	denotes	overall
T5206	24814-24821	NN	denotes	pattern
T5208	24822-24824	IN	denotes	of
T5209	24825-24836	NN	denotes	innervation
T5210	24836-24837	.	denotes	.
T5211	24837-25045	sentence	denotes	Moreover, all of the neurotrophin/neurotrophin receptor null mutants studied to date eliminate expression in both the peripheral target and the brain simultaneously and achieve their effects in late embryos.
T5212	24838-24846	RB	denotes	Moreover
T5214	24846-24848	,	denotes	,
T5215	24848-24851	DT	denotes	all
T5216	24852-24854	IN	denotes	of
T5217	24855-24858	DT	denotes	the
T5219	24859-24871	NN	denotes	neurotrophin
T5221	24871-24872	HYPH	denotes	/
T5220	24872-24884	NN	denotes	neurotrophin
T5222	24885-24893	NN	denotes	receptor
T5223	24894-24898	JJ	denotes	null
T5218	24899-24906	NNS	denotes	mutants
T5224	24907-24914	VBN	denotes	studied
T5225	24915-24917	IN	denotes	to
T5226	24918-24922	NN	denotes	date
T5213	24923-24932	VBP	denotes	eliminate
T5227	24933-24943	NN	denotes	expression
T5228	24944-24946	IN	denotes	in
T5229	24947-24951	CC	denotes	both
T5231	24952-24955	DT	denotes	the
T5232	24956-24966	JJ	denotes	peripheral
T5230	24967-24973	NN	denotes	target
T5233	24974-24977	CC	denotes	and
T5234	24978-24981	DT	denotes	the
T5235	24982-24987	NN	denotes	brain
T5236	24988-25002	RB	denotes	simultaneously
T5237	25003-25006	CC	denotes	and
T5238	25007-25014	VBP	denotes	achieve
T5239	25015-25020	PRP$	denotes	their
T5240	25021-25028	NNS	denotes	effects
T5241	25029-25031	IN	denotes	in
T5242	25032-25036	JJ	denotes	late
T5243	25037-25044	NNS	denotes	embryos
T5244	25044-25045	.	denotes	.
T5245	25045-25211	sentence	denotes	In contrast, Brn3c is barely expressed during embryogenesis in the CNS [22] thus arguing that the survival of ear primary neurons depends crucially on the periphery.
T5246	25046-25048	IN	denotes	In
T5248	25049-25057	NN	denotes	contrast
T5249	25057-25059	,	denotes	,
T5250	25059-25064	NN	denotes	Brn3c
T5251	25065-25067	VBZ	denotes	is
T5252	25068-25074	RB	denotes	barely
T5247	25075-25084	VBN	denotes	expressed
T5253	25085-25091	IN	denotes	during
T5254	25092-25105	NN	denotes	embryogenesis
T5255	25106-25108	IN	denotes	in
T5256	25109-25112	DT	denotes	the
T5257	25113-25116	NN	denotes	CNS
T5258	25117-25118	-LRB-	denotes	[
T5259	25118-25120	CD	denotes	22
T5260	25120-25121	-RRB-	denotes	]
T5261	25122-25126	RB	denotes	thus
T5262	25127-25134	VBG	denotes	arguing
T5263	25135-25139	IN	denotes	that
T5265	25140-25143	DT	denotes	the
T5266	25144-25152	NN	denotes	survival
T5267	25153-25155	IN	denotes	of
T5268	25156-25159	JJ	denotes	ear
T5270	25160-25167	JJ	denotes	primary
T5269	25168-25175	NNS	denotes	neurons
T5264	25176-25183	VBZ	denotes	depends
T5271	25184-25193	RB	denotes	crucially
T5272	25194-25196	IN	denotes	on
T5273	25197-25200	DT	denotes	the
T5274	25201-25210	NN	denotes	periphery
T5275	25210-25211	.	denotes	.
T5276	25211-25398	sentence	denotes	We suggest that limited expression of neurotrophins in the immature target leads to retention of primary neurons and their afferent fibers in newborn and early postnatal Brn3c null mice.
T5277	25212-25214	PRP	denotes	We
T5278	25215-25222	VBP	denotes	suggest
T5279	25223-25227	IN	denotes	that
T5281	25228-25235	JJ	denotes	limited
T5282	25236-25246	NN	denotes	expression
T5283	25247-25249	IN	denotes	of
T5284	25250-25263	NNS	denotes	neurotrophins
T5285	25264-25266	IN	denotes	in
T5286	25267-25270	DT	denotes	the
T5288	25271-25279	JJ	denotes	immature
T5287	25280-25286	NN	denotes	target
T5280	25287-25292	VBZ	denotes	leads
T5289	25293-25295	IN	denotes	to
T5290	25296-25305	NN	denotes	retention
T5291	25306-25308	IN	denotes	of
T5292	25309-25316	JJ	denotes	primary
T5293	25317-25324	NNS	denotes	neurons
T5294	25325-25328	CC	denotes	and
T5295	25329-25334	PRP$	denotes	their
T5297	25335-25343	JJ	denotes	afferent
T5296	25344-25350	NNS	denotes	fibers
T5298	25351-25353	IN	denotes	in
T5299	25354-25361	JJ	denotes	newborn
T5301	25362-25365	CC	denotes	and
T5302	25366-25371	JJ	denotes	early
T5303	25372-25381	JJ	denotes	postnatal
T5304	25382-25387	NN	denotes	Brn3c
T5305	25388-25392	JJ	denotes	null
T5300	25393-25397	NNS	denotes	mice
T5306	25397-25398	.	denotes	.
T5307	25398-25510	sentence	denotes	In agreement with this suggestion, our in situ data show a severe reduction in expression of BDNF (Figs. 8, 9).
T5308	25399-25401	IN	denotes	In
T5310	25402-25411	NN	denotes	agreement
T5311	25412-25416	IN	denotes	with
T5312	25417-25421	DT	denotes	this
T5313	25422-25432	NN	denotes	suggestion
T5314	25432-25434	,	denotes	,
T5315	25434-25437	PRP$	denotes	our
T5317	25438-25440	FW	denotes	in
T5318	25441-25445	FW	denotes	situ
T5316	25446-25450	NNS	denotes	data
T5309	25451-25455	VBP	denotes	show
T5319	25456-25457	DT	denotes	a
T5321	25458-25464	JJ	denotes	severe
T5320	25465-25474	NN	denotes	reduction
T5322	25475-25477	IN	denotes	in
T5323	25478-25488	NN	denotes	expression
T5324	25489-25491	IN	denotes	of
T5325	25492-25496	NN	denotes	BDNF
T5326	25497-25498	-LRB-	denotes	(
T5328	25498-25503	NNS	denotes	Figs.
T5329	25504-25505	CD	denotes	8
T5330	25505-25507	,	denotes	,
T5327	25507-25508	CD	denotes	9
T5331	25508-25509	-RRB-	denotes	)
T5332	25509-25510	.	denotes	.
T5333	25510-25687	sentence	denotes	Despite this reduction, some, apparently biologically significant low levels of neurotrophins are apparently expressed in all sensory epithelia in embryonic Brn3c null mutants.
T5334	25511-25518	IN	denotes	Despite
T5336	25519-25523	DT	denotes	this
T5337	25524-25533	NN	denotes	reduction
T5338	25533-25535	,	denotes	,
T5339	25535-25539	DT	denotes	some
T5341	25539-25541	,	denotes	,
T5342	25541-25551	RB	denotes	apparently
T5344	25552-25564	RB	denotes	biologically
T5343	25565-25576	JJ	denotes	significant
T5345	25577-25580	JJ	denotes	low
T5340	25581-25587	NNS	denotes	levels
T5346	25588-25590	IN	denotes	of
T5347	25591-25604	NNS	denotes	neurotrophins
T5348	25605-25608	VBP	denotes	are
T5349	25609-25619	RB	denotes	apparently
T5335	25620-25629	VBN	denotes	expressed
T5350	25630-25632	IN	denotes	in
T5351	25633-25636	DT	denotes	all
T5353	25637-25644	JJ	denotes	sensory
T5352	25645-25654	NNS	denotes	epithelia
T5354	25655-25657	IN	denotes	in
T5355	25658-25667	JJ	denotes	embryonic
T5357	25668-25673	NN	denotes	Brn3c
T5358	25674-25678	JJ	denotes	null
T5356	25679-25686	NNS	denotes	mutants
T5359	25686-25687	.	denotes	.
T5360	25687-25849	sentence	denotes	It appears that even these low levels of neurotrophins in the vestibular sensory epithelia can sustain normal fiber outgrowth and a limited maintenance until P0.
T5361	25688-25690	PRP	denotes	It
T5362	25691-25698	VBZ	denotes	appears
T5363	25699-25703	IN	denotes	that
T5365	25704-25708	RB	denotes	even
T5367	25709-25714	DT	denotes	these
T5368	25715-25718	JJ	denotes	low
T5366	25719-25725	NNS	denotes	levels
T5369	25726-25728	IN	denotes	of
T5370	25729-25742	NNS	denotes	neurotrophins
T5371	25743-25745	IN	denotes	in
T5372	25746-25749	DT	denotes	the
T5374	25750-25760	JJ	denotes	vestibular
T5375	25761-25768	JJ	denotes	sensory
T5373	25769-25778	NNS	denotes	epithelia
T5376	25779-25782	MD	denotes	can
T5364	25783-25790	VB	denotes	sustain
T5377	25791-25797	JJ	denotes	normal
T5379	25798-25803	NN	denotes	fiber
T5378	25804-25813	NN	denotes	outgrowth
T5380	25814-25817	CC	denotes	and
T5381	25818-25819	DT	denotes	a
T5383	25820-25827	VBN	denotes	limited
T5382	25828-25839	NN	denotes	maintenance
T5384	25840-25845	IN	denotes	until
T5385	25846-25848	NN	denotes	P0
T5386	25848-25849	.	denotes	.
T5387	25849-26131	sentence	denotes	The comparatively high level of NT-3 expression in Brn3c null mutant cochlea, which has been shown to be the neurotrophin most prominently supporting spiral sensory neurons [6,9,14], is in agreement with the normal development of cochlear innervation in newborn Brn3c null mutants.
T5388	25850-25853	DT	denotes	The
T5390	25854-25867	RB	denotes	comparatively
T5391	25868-25872	JJ	denotes	high
T5389	25873-25878	NN	denotes	level
T5393	25879-25881	IN	denotes	of
T5394	25882-25884	NN	denotes	NT
T5396	25884-25885	HYPH	denotes	-
T5397	25885-25886	CD	denotes	3
T5395	25887-25897	NN	denotes	expression
T5398	25898-25900	IN	denotes	in
T5399	25901-25906	NN	denotes	Brn3c
T5401	25907-25911	JJ	denotes	null
T5402	25912-25918	JJ	denotes	mutant
T5400	25919-25926	NN	denotes	cochlea
T5403	25926-25928	,	denotes	,
T5404	25928-25933	WDT	denotes	which
T5406	25934-25937	VBZ	denotes	has
T5407	25938-25942	VBN	denotes	been
T5405	25943-25948	VBN	denotes	shown
T5408	25949-25951	TO	denotes	to
T5409	25952-25954	VB	denotes	be
T5410	25955-25958	DT	denotes	the
T5411	25959-25971	NN	denotes	neurotrophin
T5412	25972-25976	RBS	denotes	most
T5413	25977-25988	RB	denotes	prominently
T5414	25989-25999	VBG	denotes	supporting
T5415	26000-26006	JJ	denotes	spiral
T5417	26007-26014	JJ	denotes	sensory
T5416	26015-26022	NNS	denotes	neurons
T5418	26023-26024	-LRB-	denotes	[
T5420	26024-26025	CD	denotes	6
T5421	26025-26026	,	denotes	,
T5422	26026-26027	CD	denotes	9
T5423	26027-26028	,	denotes	,
T5419	26028-26030	CD	denotes	14
T5424	26030-26031	-RRB-	denotes	]
T5425	26031-26033	,	denotes	,
T5392	26033-26035	VBZ	denotes	is
T5426	26036-26038	IN	denotes	in
T5427	26039-26048	NN	denotes	agreement
T5428	26049-26053	IN	denotes	with
T5429	26054-26057	DT	denotes	the
T5431	26058-26064	JJ	denotes	normal
T5430	26065-26076	NN	denotes	development
T5432	26077-26079	IN	denotes	of
T5433	26080-26088	JJ	denotes	cochlear
T5434	26089-26100	NN	denotes	innervation
T5435	26101-26103	IN	denotes	in
T5436	26104-26111	JJ	denotes	newborn
T5438	26112-26117	NN	denotes	Brn3c
T5439	26118-26122	JJ	denotes	null
T5437	26123-26130	NNS	denotes	mutants
T5440	26130-26131	.	denotes	.
T5441	26131-26360	sentence	denotes	Since BDNF appears to be exclusively produced by hair cells [6,7,20], the lack of terminal differentiation of hair cells appears to be accompanied by only limited expression of BDNF, as is the case in the canal cristae (Fig. 8).
T5442	26132-26137	IN	denotes	Since
T5444	26138-26142	NN	denotes	BDNF
T5443	26143-26150	VBZ	denotes	appears
T5446	26151-26153	TO	denotes	to
T5448	26154-26156	VB	denotes	be
T5449	26157-26168	RB	denotes	exclusively
T5447	26169-26177	VBN	denotes	produced
T5450	26178-26180	IN	denotes	by
T5451	26181-26185	NN	denotes	hair
T5452	26186-26191	NNS	denotes	cells
T5453	26192-26193	-LRB-	denotes	[
T5455	26193-26194	CD	denotes	6
T5456	26194-26195	,	denotes	,
T5457	26195-26196	CD	denotes	7
T5458	26196-26197	,	denotes	,
T5454	26197-26199	CD	denotes	20
T5459	26199-26200	-RRB-	denotes	]
T5460	26200-26202	,	denotes	,
T5461	26202-26205	DT	denotes	the
T5462	26206-26210	NN	denotes	lack
T5463	26211-26213	IN	denotes	of
T5464	26214-26222	JJ	denotes	terminal
T5465	26223-26238	NN	denotes	differentiation
T5466	26239-26241	IN	denotes	of
T5467	26242-26246	NN	denotes	hair
T5468	26247-26252	NNS	denotes	cells
T5445	26253-26260	VBZ	denotes	appears
T5469	26261-26263	TO	denotes	to
T5471	26264-26266	VB	denotes	be
T5470	26267-26278	VBN	denotes	accompanied
T5472	26279-26281	IN	denotes	by
T5473	26282-26286	RB	denotes	only
T5475	26287-26294	JJ	denotes	limited
T5474	26295-26305	NN	denotes	expression
T5476	26306-26308	IN	denotes	of
T5477	26309-26313	NN	denotes	BDNF
T5478	26313-26315	,	denotes	,
T5479	26315-26317	IN	denotes	as
T5480	26318-26320	VBZ	denotes	is
T5481	26321-26324	DT	denotes	the
T5482	26325-26329	NN	denotes	case
T5483	26330-26332	IN	denotes	in
T5484	26333-26336	DT	denotes	the
T5486	26337-26342	NN	denotes	canal
T5485	26343-26350	NNS	denotes	cristae
T5487	26351-26352	-LRB-	denotes	(
T5488	26352-26356	NN	denotes	Fig.
T5489	26357-26358	CD	denotes	8
T5490	26358-26359	-RRB-	denotes	)
T5491	26359-26360	.	denotes	.
T5492	26360-26482	sentence	denotes	Past research has shown that in BDNF and trkB null mutants this innervation to canal cristae is lost before birth [6,13].
T5493	26361-26365	NN	denotes	Past
T5494	26366-26374	NN	denotes	research
T5496	26375-26378	VBZ	denotes	has
T5495	26379-26384	VBN	denotes	shown
T5497	26385-26389	IN	denotes	that
T5499	26390-26392	IN	denotes	in
T5500	26393-26397	NN	denotes	BDNF
T5502	26398-26401	CC	denotes	and
T5503	26402-26406	NN	denotes	trkB
T5504	26407-26411	JJ	denotes	null
T5501	26412-26419	NNS	denotes	mutants
T5505	26420-26424	DT	denotes	this
T5506	26425-26436	NN	denotes	innervation
T5507	26437-26439	IN	denotes	to
T5508	26440-26445	JJ	denotes	canal
T5509	26446-26453	NNS	denotes	cristae
T5510	26454-26456	VBZ	denotes	is
T5498	26457-26461	VBN	denotes	lost
T5511	26462-26468	IN	denotes	before
T5512	26469-26474	NN	denotes	birth
T5513	26475-26476	-LRB-	denotes	[
T5515	26476-26477	CD	denotes	6
T5516	26477-26478	,	denotes	,
T5514	26478-26480	CD	denotes	13
T5517	26480-26481	-RRB-	denotes	]
T5518	26481-26482	.	denotes	.
T5519	26482-26683	sentence	denotes	That even these low levels of expression are significant is clear from the fact that all canal sensory epithelia receive an innervation by both afferents and efferents at birth and later (Figs. 2, 3).
T5520	26483-26487	IN	denotes	That
T5522	26488-26492	RB	denotes	even
T5524	26493-26498	DT	denotes	these
T5525	26499-26502	JJ	denotes	low
T5523	26503-26509	NNS	denotes	levels
T5526	26510-26512	IN	denotes	of
T5527	26513-26523	NN	denotes	expression
T5521	26524-26527	VBP	denotes	are
T5529	26528-26539	JJ	denotes	significant
T5528	26540-26542	VBZ	denotes	is
T5530	26543-26548	JJ	denotes	clear
T5531	26549-26553	IN	denotes	from
T5532	26554-26557	DT	denotes	the
T5533	26558-26562	NN	denotes	fact
T5534	26563-26567	IN	denotes	that
T5536	26568-26571	DT	denotes	all
T5538	26572-26577	JJ	denotes	canal
T5539	26578-26585	JJ	denotes	sensory
T5537	26586-26595	NNS	denotes	epithelia
T5535	26596-26603	VBP	denotes	receive
T5540	26604-26606	DT	denotes	an
T5541	26607-26618	NN	denotes	innervation
T5542	26619-26621	IN	denotes	by
T5543	26622-26626	CC	denotes	both
T5544	26627-26636	NNS	denotes	afferents
T5545	26637-26640	CC	denotes	and
T5546	26641-26650	NNS	denotes	efferents
T5547	26651-26653	IN	denotes	at
T5548	26654-26659	NN	denotes	birth
T5549	26660-26663	CC	denotes	and
T5550	26664-26669	RB	denotes	later
T5551	26670-26671	-LRB-	denotes	(
T5553	26671-26676	NNS	denotes	Figs.
T5554	26677-26678	CD	denotes	2
T5555	26678-26680	,	denotes	,
T5552	26680-26681	CD	denotes	3
T5556	26681-26682	-RRB-	denotes	)
T5557	26682-26683	.	denotes	.
T5558	26683-26790	sentence	denotes	The situation in the utricle, saccule and cochlea is less clear as both BDNF and NT-3 are expressed [6,7].
T5559	26684-26687	DT	denotes	The
T5560	26688-26697	NN	denotes	situation
T5562	26698-26700	IN	denotes	in
T5563	26701-26704	DT	denotes	the
T5564	26705-26712	NN	denotes	utricle
T5565	26712-26714	,	denotes	,
T5566	26714-26721	NN	denotes	saccule
T5567	26722-26725	CC	denotes	and
T5568	26726-26733	NN	denotes	cochlea
T5561	26734-26736	VBZ	denotes	is
T5569	26737-26741	RBR	denotes	less
T5570	26742-26747	JJ	denotes	clear
T5571	26748-26750	IN	denotes	as
T5573	26751-26755	CC	denotes	both
T5574	26756-26760	NN	denotes	BDNF
T5575	26761-26764	CC	denotes	and
T5576	26765-26767	NN	denotes	NT
T5577	26767-26768	HYPH	denotes	-
T5578	26768-26769	CD	denotes	3
T5579	26770-26773	VBP	denotes	are
T5572	26774-26783	VBN	denotes	expressed
T5580	26784-26785	-LRB-	denotes	[
T5582	26785-26786	CD	denotes	6
T5583	26786-26787	,	denotes	,
T5581	26787-26788	CD	denotes	7
T5584	26788-26789	-RRB-	denotes	]
T5585	26789-26790	.	denotes	.
T5586	26790-26907	sentence	denotes	In fact, it appears that the levels of NT-3 expression hardly differ from those in control littermates (Figs. 8, 9).
T5587	26791-26793	IN	denotes	In
T5589	26794-26798	NN	denotes	fact
T5590	26798-26800	,	denotes	,
T5591	26800-26802	PRP	denotes	it
T5588	26803-26810	VBZ	denotes	appears
T5592	26811-26815	IN	denotes	that
T5594	26816-26819	DT	denotes	the
T5595	26820-26826	NNS	denotes	levels
T5596	26827-26829	IN	denotes	of
T5597	26830-26832	NN	denotes	NT
T5599	26832-26833	HYPH	denotes	-
T5600	26833-26834	CD	denotes	3
T5598	26835-26845	NN	denotes	expression
T5601	26846-26852	RB	denotes	hardly
T5593	26853-26859	VBP	denotes	differ
T5602	26860-26864	IN	denotes	from
T5603	26865-26870	DT	denotes	those
T5604	26871-26873	IN	denotes	in
T5605	26874-26881	NN	denotes	control
T5606	26882-26893	NNS	denotes	littermates
T5607	26894-26895	-LRB-	denotes	(
T5609	26895-26900	NNS	denotes	Figs.
T5610	26901-26902	CD	denotes	8
T5611	26902-26904	,	denotes	,
T5608	26904-26905	CD	denotes	9
T5612	26905-26906	-RRB-	denotes	)
T5613	26906-26907	.	denotes	.
T5614	26907-26970	sentence	denotes	The latter is particularly obvious in the apex of the cochlea.
T5615	26908-26911	DT	denotes	The
T5616	26912-26918	JJ	denotes	latter
T5617	26919-26921	VBZ	denotes	is
T5618	26922-26934	RB	denotes	particularly
T5619	26935-26942	JJ	denotes	obvious
T5620	26943-26945	IN	denotes	in
T5621	26946-26949	DT	denotes	the
T5622	26950-26954	NN	denotes	apex
T5623	26955-26957	IN	denotes	of
T5624	26958-26961	DT	denotes	the
T5625	26962-26969	NN	denotes	cochlea
T5626	26969-26970	.	denotes	.
T5627	26970-27125	sentence	denotes	In fact, in the cochlea of embryos and neonates as well as in the saccule and utricle of embryos, NT-3 is predominantly expressed in supporting cells [6].
T5628	26971-26973	IN	denotes	In
T5630	26974-26978	NN	denotes	fact
T5631	26978-26980	,	denotes	,
T5632	26980-26982	IN	denotes	in
T5633	26983-26986	DT	denotes	the
T5634	26987-26994	NN	denotes	cochlea
T5635	26995-26997	IN	denotes	of
T5636	26998-27005	NNS	denotes	embryos
T5637	27006-27009	CC	denotes	and
T5638	27010-27018	NNS	denotes	neonates
T5639	27019-27021	RB	denotes	as
T5641	27022-27026	RB	denotes	well
T5640	27027-27029	IN	denotes	as
T5642	27030-27032	IN	denotes	in
T5643	27033-27036	DT	denotes	the
T5644	27037-27044	NN	denotes	saccule
T5645	27045-27048	CC	denotes	and
T5646	27049-27056	NN	denotes	utricle
T5647	27057-27059	IN	denotes	of
T5648	27060-27067	NNS	denotes	embryos
T5649	27067-27069	,	denotes	,
T5650	27069-27071	NN	denotes	NT
T5651	27071-27072	HYPH	denotes	-
T5652	27072-27073	CD	denotes	3
T5653	27074-27076	VBZ	denotes	is
T5654	27077-27090	RB	denotes	predominantly
T5629	27091-27100	VBN	denotes	expressed
T5655	27101-27103	IN	denotes	in
T5656	27104-27114	VBG	denotes	supporting
T5657	27115-27120	NNS	denotes	cells
T5658	27121-27122	-LRB-	denotes	[
T5659	27122-27123	CD	denotes	6
T5660	27123-27124	-RRB-	denotes	]
T5661	27124-27125	.	denotes	.
T5662	27125-27316	sentence	denotes	This expression of NT-3 in supporting cells in embryos and neonates may even preserve in Brn3c null mutants the numerous spiral sensory neurons in the apex of 8-day old animals (Figs. 3, 4).
T5663	27126-27130	DT	denotes	This
T5664	27131-27141	NN	denotes	expression
T5666	27142-27144	IN	denotes	of
T5667	27145-27147	NN	denotes	NT
T5668	27147-27148	HYPH	denotes	-
T5669	27148-27149	CD	denotes	3
T5670	27150-27152	IN	denotes	in
T5671	27153-27163	VBG	denotes	supporting
T5672	27164-27169	NNS	denotes	cells
T5673	27170-27172	IN	denotes	in
T5674	27173-27180	NNS	denotes	embryos
T5675	27181-27184	CC	denotes	and
T5676	27185-27193	NNS	denotes	neonates
T5677	27194-27197	MD	denotes	may
T5678	27198-27202	RB	denotes	even
T5665	27203-27211	VB	denotes	preserve
T5679	27212-27214	IN	denotes	in
T5680	27215-27220	NN	denotes	Brn3c
T5682	27221-27225	JJ	denotes	null
T5681	27226-27233	NNS	denotes	mutants
T5683	27234-27237	DT	denotes	the
T5685	27238-27246	JJ	denotes	numerous
T5686	27247-27253	JJ	denotes	spiral
T5687	27254-27261	JJ	denotes	sensory
T5684	27262-27269	NNS	denotes	neurons
T5688	27270-27272	IN	denotes	in
T5689	27273-27276	DT	denotes	the
T5690	27277-27281	NN	denotes	apex
T5691	27282-27284	IN	denotes	of
T5692	27285-27286	CD	denotes	8
T5694	27286-27287	HYPH	denotes	-
T5693	27287-27290	NN	denotes	day
T5695	27291-27294	JJ	denotes	old
T5696	27295-27302	NNS	denotes	animals
T5697	27303-27304	-LRB-	denotes	(
T5699	27304-27309	NNS	denotes	Figs.
T5700	27310-27311	CD	denotes	3
T5701	27311-27313	,	denotes	,
T5698	27313-27314	CD	denotes	4
T5702	27314-27315	-RRB-	denotes	)
T5703	27315-27316	.	denotes	.
T5839	27318-27322	JJ	denotes	Long
T5840	27323-27327	NN	denotes	term
T5841	27328-27336	NN	denotes	survival
T5843	27337-27339	IN	denotes	of
T5844	27340-27346	JJ	denotes	apical
T5846	27347-27354	JJ	denotes	sensory
T5845	27355-27362	NNS	denotes	neurons
T5842	27363-27365	VBZ	denotes	is
T5847	27366-27375	JJ	denotes	unrelated
T5848	27376-27378	IN	denotes	to
T5849	27379-27393	JJ	denotes	differentiated
T5851	27394-27398	NN	denotes	hair
T5850	27399-27404	NNS	denotes	cells
T5852	27405-27408	CC	denotes	and
T5853	27409-27415	RB	denotes	likely
T5854	27416-27418	VBZ	denotes	is
T5855	27419-27430	JJ	denotes	independent
T5856	27431-27433	IN	denotes	of
T5857	27434-27447	NNS	denotes	neurotrophins
T5858	27447-27632	sentence	denotes	Past work has shown that BDNF and NT-3 appear to shift in their expression into inner hair cells around birth or are lost in the ear and other parts of the nervous system [6,10,20,23].
T5859	27448-27452	NN	denotes	Past
T5860	27453-27457	NN	denotes	work
T5862	27458-27461	VBZ	denotes	has
T5861	27462-27467	VBN	denotes	shown
T5863	27468-27472	IN	denotes	that
T5865	27473-27477	NN	denotes	BDNF
T5866	27478-27481	CC	denotes	and
T5867	27482-27484	NN	denotes	NT
T5868	27484-27485	HYPH	denotes	-
T5869	27485-27486	CD	denotes	3
T5864	27487-27493	VBP	denotes	appear
T5870	27494-27496	TO	denotes	to
T5871	27497-27502	VB	denotes	shift
T5872	27503-27505	IN	denotes	in
T5873	27506-27511	PRP$	denotes	their
T5874	27512-27522	NN	denotes	expression
T5875	27523-27527	IN	denotes	into
T5876	27528-27533	JJ	denotes	inner
T5878	27534-27538	NN	denotes	hair
T5877	27539-27544	NNS	denotes	cells
T5879	27545-27551	IN	denotes	around
T5880	27552-27557	NN	denotes	birth
T5881	27558-27560	CC	denotes	or
T5882	27561-27564	VBP	denotes	are
T5883	27565-27569	VBN	denotes	lost
T5884	27570-27572	IN	denotes	in
T5885	27573-27576	DT	denotes	the
T5886	27577-27580	NN	denotes	ear
T5887	27581-27584	CC	denotes	and
T5888	27585-27590	JJ	denotes	other
T5889	27591-27596	NNS	denotes	parts
T5890	27597-27599	IN	denotes	of
T5891	27600-27603	DT	denotes	the
T5893	27604-27611	JJ	denotes	nervous
T5892	27612-27618	NN	denotes	system
T5894	27619-27620	-LRB-	denotes	[
T5896	27620-27621	CD	denotes	6
T5897	27621-27622	,	denotes	,
T5898	27622-27624	CD	denotes	10
T5899	27624-27625	,	denotes	,
T5900	27625-27627	CD	denotes	20
T5901	27627-27628	,	denotes	,
T5895	27628-27630	CD	denotes	23
T5902	27630-27631	-RRB-	denotes	]
T5903	27631-27632	.	denotes	.
T5904	27632-27715	sentence	denotes	It has been suggested that other neurotrophins may come into play in the ear [11].
T5905	27633-27635	PRP	denotes	It
T5907	27636-27639	VBZ	denotes	has
T5908	27640-27644	VBN	denotes	been
T5906	27645-27654	VBN	denotes	suggested
T5909	27655-27659	IN	denotes	that
T5911	27660-27665	JJ	denotes	other
T5912	27666-27679	NNS	denotes	neurotrophins
T5913	27680-27683	MD	denotes	may
T5910	27684-27688	VB	denotes	come
T5914	27689-27693	IN	denotes	into
T5915	27694-27698	NN	denotes	play
T5916	27699-27701	IN	denotes	in
T5917	27702-27705	DT	denotes	the
T5918	27706-27709	NN	denotes	ear
T5919	27710-27711	-LRB-	denotes	[
T5920	27711-27713	CD	denotes	11
T5921	27713-27714	-RRB-	denotes	]
T5922	27714-27715	.	denotes	.
T5923	27715-27899	sentence	denotes	However, the apex of Brn3c null mutants, which retains most of the spiral neuron afferents at 6-month, shows no formation of mature hair cells at any time surveyed here (P0, P8, P10).
T5924	27716-27723	RB	denotes	However
T5926	27723-27725	,	denotes	,
T5927	27725-27728	DT	denotes	the
T5928	27729-27733	NN	denotes	apex
T5929	27734-27736	IN	denotes	of
T5930	27737-27742	NN	denotes	Brn3c
T5932	27743-27747	JJ	denotes	null
T5931	27748-27755	NNS	denotes	mutants
T5933	27755-27757	,	denotes	,
T5934	27757-27762	WDT	denotes	which
T5935	27763-27770	VBZ	denotes	retains
T5936	27771-27775	JJS	denotes	most
T5937	27776-27778	IN	denotes	of
T5938	27779-27782	DT	denotes	the
T5940	27783-27789	JJ	denotes	spiral
T5941	27790-27796	NN	denotes	neuron
T5939	27797-27806	NNS	denotes	afferents
T5942	27807-27809	IN	denotes	at
T5943	27810-27811	CD	denotes	6
T5945	27811-27812	HYPH	denotes	-
T5944	27812-27817	NN	denotes	month
T5946	27817-27819	,	denotes	,
T5925	27819-27824	VBZ	denotes	shows
T5947	27825-27827	DT	denotes	no
T5948	27828-27837	NN	denotes	formation
T5949	27838-27840	IN	denotes	of
T5950	27841-27847	JJ	denotes	mature
T5952	27848-27852	NN	denotes	hair
T5951	27853-27858	NNS	denotes	cells
T5953	27859-27861	IN	denotes	at
T5954	27862-27865	DT	denotes	any
T5955	27866-27870	NN	denotes	time
T5956	27871-27879	VBN	denotes	surveyed
T5957	27880-27884	RB	denotes	here
T5958	27885-27886	-LRB-	denotes	(
T5960	27886-27888	NN	denotes	P0
T5961	27888-27890	,	denotes	,
T5962	27890-27892	NN	denotes	P8
T5963	27892-27894	,	denotes	,
T5959	27894-27897	NN	denotes	P10
T5964	27897-27898	-RRB-	denotes	)
T5965	27898-27899	.	denotes	.
T5966	27899-28097	sentence	denotes	Thus the factor(s) cannot be released by differentiated hair cells but there is an unexplored possibility of generalized expression of neurotrophins at low levels in the undifferentiated epithelia.
T5967	27900-27904	RB	denotes	Thus
T5969	27905-27908	DT	denotes	the
T5970	27909-27915	NN	denotes	factor
T5971	27915-27916	-LRB-	denotes	(
T5972	27916-27917	AFX	denotes	s
T5973	27917-27918	-RRB-	denotes	)
T5974	27919-27922	MD	denotes	can
T5975	27922-27925	RB	denotes	not
T5976	27926-27928	VB	denotes	be
T5968	27929-27937	VBN	denotes	released
T5977	27938-27940	IN	denotes	by
T5978	27941-27955	VBN	denotes	differentiated
T5980	27956-27960	NN	denotes	hair
T5979	27961-27966	NNS	denotes	cells
T5981	27967-27970	CC	denotes	but
T5982	27971-27976	EX	denotes	there
T5983	27977-27979	VBZ	denotes	is
T5984	27980-27982	DT	denotes	an
T5986	27983-27993	JJ	denotes	unexplored
T5985	27994-28005	NN	denotes	possibility
T5987	28006-28008	IN	denotes	of
T5988	28009-28020	VBN	denotes	generalized
T5989	28021-28031	NN	denotes	expression
T5990	28032-28034	IN	denotes	of
T5991	28035-28048	NNS	denotes	neurotrophins
T5992	28049-28051	IN	denotes	at
T5993	28052-28055	JJ	denotes	low
T5994	28056-28062	NNS	denotes	levels
T5995	28063-28065	IN	denotes	in
T5996	28066-28069	DT	denotes	the
T5998	28070-28086	JJ	denotes	undifferentiated
T5997	28087-28096	NNS	denotes	epithelia
T5999	28096-28097	.	denotes	.
T6000	28097-28283	sentence	denotes	However, known neurotrophins are largely absent in the adult cochleae [4] and significant amounts of neurotrophin expression appear to develop only in postnatal animals in the CNS [24].
T6001	28098-28105	RB	denotes	However
T6003	28105-28107	,	denotes	,
T6004	28107-28112	VBN	denotes	known
T6005	28113-28126	NNS	denotes	neurotrophins
T6002	28127-28130	VBP	denotes	are
T6006	28131-28138	RB	denotes	largely
T6007	28139-28145	JJ	denotes	absent
T6008	28146-28148	IN	denotes	in
T6009	28149-28152	DT	denotes	the
T6011	28153-28158	JJ	denotes	adult
T6010	28159-28167	NNS	denotes	cochleae
T6012	28168-28169	-LRB-	denotes	[
T6013	28169-28170	CD	denotes	4
T6014	28170-28171	-RRB-	denotes	]
T6015	28172-28175	CC	denotes	and
T6016	28176-28187	JJ	denotes	significant
T6017	28188-28195	NNS	denotes	amounts
T6019	28196-28198	IN	denotes	of
T6020	28199-28211	NN	denotes	neurotrophin
T6021	28212-28222	NN	denotes	expression
T6018	28223-28229	VBP	denotes	appear
T6022	28230-28232	TO	denotes	to
T6023	28233-28240	VB	denotes	develop
T6024	28241-28245	RB	denotes	only
T6025	28246-28248	IN	denotes	in
T6026	28249-28258	JJ	denotes	postnatal
T6027	28259-28266	NNS	denotes	animals
T6028	28267-28269	IN	denotes	in
T6029	28270-28273	DT	denotes	the
T6030	28274-28277	NN	denotes	CNS
T6031	28278-28279	-LRB-	denotes	[
T6032	28279-28281	CD	denotes	24
T6033	28281-28282	-RRB-	denotes	]
T6034	28282-28283	.	denotes	.
T6035	28283-28408	sentence	denotes	Such expression in the CNS could possibly offset to some extent the peripheral loss of neutrophins in targeted null mutants.
T6036	28284-28288	JJ	denotes	Such
T6037	28289-28299	NN	denotes	expression
T6039	28300-28302	IN	denotes	in
T6040	28303-28306	DT	denotes	the
T6041	28307-28310	NN	denotes	CNS
T6042	28311-28316	MD	denotes	could
T6043	28317-28325	RB	denotes	possibly
T6038	28326-28332	VB	denotes	offset
T6044	28333-28335	IN	denotes	to
T6045	28336-28340	DT	denotes	some
T6046	28341-28347	NN	denotes	extent
T6047	28348-28351	DT	denotes	the
T6049	28352-28362	JJ	denotes	peripheral
T6048	28363-28367	NN	denotes	loss
T6050	28368-28370	IN	denotes	of
T6051	28371-28382	NNS	denotes	neutrophins
T6052	28383-28385	IN	denotes	in
T6053	28386-28394	VBN	denotes	targeted
T6055	28395-28399	JJ	denotes	null
T6054	28400-28407	NNS	denotes	mutants
T6056	28407-28408	.	denotes	.
T6057	28408-28558	sentence	denotes	This would work only in cases in which the loss of primary neurons would not already be completed long before birth as is the case in the ear [6,13].
T6058	28409-28413	DT	denotes	This
T6060	28414-28419	MD	denotes	would
T6059	28420-28424	VB	denotes	work
T6061	28425-28429	RB	denotes	only
T6062	28430-28432	IN	denotes	in
T6063	28433-28438	NNS	denotes	cases
T6064	28439-28441	IN	denotes	in
T6066	28442-28447	WDT	denotes	which
T6067	28448-28451	DT	denotes	the
T6068	28452-28456	NN	denotes	loss
T6069	28457-28459	IN	denotes	of
T6070	28460-28467	JJ	denotes	primary
T6071	28468-28475	NNS	denotes	neurons
T6072	28476-28481	MD	denotes	would
T6073	28482-28485	RB	denotes	not
T6074	28486-28493	RB	denotes	already
T6075	28494-28496	VB	denotes	be
T6065	28497-28506	VBN	denotes	completed
T6076	28507-28511	RB	denotes	long
T6077	28512-28518	IN	denotes	before
T6078	28519-28524	NN	denotes	birth
T6079	28525-28527	IN	denotes	as
T6080	28528-28530	VBZ	denotes	is
T6081	28531-28534	DT	denotes	the
T6082	28535-28539	NN	denotes	case
T6083	28540-28542	IN	denotes	in
T6084	28543-28546	DT	denotes	the
T6085	28547-28550	NN	denotes	ear
T6086	28551-28552	-LRB-	denotes	[
T6088	28552-28553	CD	denotes	6
T6089	28553-28554	,	denotes	,
T6087	28554-28556	CD	denotes	13
T6090	28556-28557	-RRB-	denotes	]
T6091	28557-28558	.	denotes	.
T6092	28558-28779	sentence	denotes	It therefore remains unclear what supports the many afferents in the apex of the Brn3c null mutants until 6 months of age or longer, unknown peripheral neurotrophic substances or neurotrophic support provided by the CNS.
T6093	28559-28561	PRP	denotes	It
T6095	28562-28571	RB	denotes	therefore
T6094	28572-28579	VBZ	denotes	remains
T6096	28580-28587	JJ	denotes	unclear
T6097	28588-28592	WP	denotes	what
T6098	28593-28601	VBZ	denotes	supports
T6099	28602-28605	DT	denotes	the
T6101	28606-28610	JJ	denotes	many
T6100	28611-28620	NNS	denotes	afferents
T6102	28621-28623	IN	denotes	in
T6103	28624-28627	DT	denotes	the
T6104	28628-28632	NN	denotes	apex
T6105	28633-28635	IN	denotes	of
T6106	28636-28639	DT	denotes	the
T6108	28640-28645	NN	denotes	Brn3c
T6109	28646-28650	JJ	denotes	null
T6107	28651-28658	NNS	denotes	mutants
T6110	28659-28664	IN	denotes	until
T6111	28665-28666	CD	denotes	6
T6112	28667-28673	NNS	denotes	months
T6113	28674-28676	IN	denotes	of
T6114	28677-28680	NN	denotes	age
T6115	28681-28683	CC	denotes	or
T6116	28684-28690	JJR	denotes	longer
T6117	28690-28692	,	denotes	,
T6118	28692-28699	JJ	denotes	unknown
T6120	28700-28710	JJ	denotes	peripheral
T6121	28711-28723	JJ	denotes	neurotrophic
T6119	28724-28734	NNS	denotes	substances
T6122	28735-28737	CC	denotes	or
T6123	28738-28750	JJ	denotes	neurotrophic
T6124	28751-28758	NN	denotes	support
T6125	28759-28767	VBN	denotes	provided
T6126	28768-28770	IN	denotes	by
T6127	28771-28774	DT	denotes	the
T6128	28775-28778	NN	denotes	CNS
T6129	28778-28779	.	denotes	.
T6130	28779-28946	sentence	denotes	Comparable long term retention of apical spiral sensory neurons was described for the deaf white cat [25] and may also be the case in humans with congenital deafness.
T6131	28780-28790	JJ	denotes	Comparable
T6133	28791-28795	JJ	denotes	long
T6134	28796-28800	NN	denotes	term
T6132	28801-28810	NN	denotes	retention
T6136	28811-28813	IN	denotes	of
T6137	28814-28820	JJ	denotes	apical
T6139	28821-28827	JJ	denotes	spiral
T6140	28828-28835	JJ	denotes	sensory
T6138	28836-28843	NNS	denotes	neurons
T6141	28844-28847	VBD	denotes	was
T6135	28848-28857	VBN	denotes	described
T6142	28858-28861	IN	denotes	for
T6143	28862-28865	DT	denotes	the
T6145	28866-28870	NN	denotes	deaf
T6146	28871-28876	JJ	denotes	white
T6144	28877-28880	NN	denotes	cat
T6147	28881-28882	-LRB-	denotes	[
T6148	28882-28884	CD	denotes	25
T6149	28884-28885	-RRB-	denotes	]
T6150	28886-28889	CC	denotes	and
T6151	28890-28893	MD	denotes	may
T6153	28894-28898	RB	denotes	also
T6152	28899-28901	VB	denotes	be
T6154	28902-28905	DT	denotes	the
T6155	28906-28910	NN	denotes	case
T6156	28911-28913	IN	denotes	in
T6157	28914-28920	NNS	denotes	humans
T6158	28921-28925	IN	denotes	with
T6159	28926-28936	JJ	denotes	congenital
T6160	28937-28945	NN	denotes	deafness
T6161	28945-28946	.	denotes	.
T6395	28948-28954	NN	denotes	Growth
T6397	28955-28957	IN	denotes	of
T6398	28958-28964	NNS	denotes	fibers
T6399	28965-28967	IN	denotes	to
T6400	28968-28971	DT	denotes	the
T6401	28972-28979	NN	denotes	cochlea
T6402	28980-28984	VBZ	denotes	does
T6403	28985-28988	RB	denotes	not
T6396	28989-28996	VB	denotes	require
T6404	28997-29003	JJ	denotes	mature
T6406	29004-29008	NN	denotes	hair
T6405	29009-29014	NNS	denotes	cells
T6407	29014-29246	sentence	denotes	Formation of radial fibers that bring peripheral processes of spiral neurons to the organ of Corti seems to be rather normal, even in the apex of the cochlea which does not even develop immature hair cells recognizable by Myo VIIa.
T6408	29015-29024	NN	denotes	Formation
T6410	29025-29027	IN	denotes	of
T6411	29028-29034	NN	denotes	radial
T6412	29035-29041	NNS	denotes	fibers
T6413	29042-29046	WDT	denotes	that
T6414	29047-29052	VBP	denotes	bring
T6415	29053-29063	JJ	denotes	peripheral
T6416	29064-29073	NNS	denotes	processes
T6417	29074-29076	IN	denotes	of
T6418	29077-29083	JJ	denotes	spiral
T6419	29084-29091	NNS	denotes	neurons
T6420	29092-29094	IN	denotes	to
T6421	29095-29098	DT	denotes	the
T6422	29099-29104	NN	denotes	organ
T6423	29105-29107	IN	denotes	of
T6424	29108-29113	NNP	denotes	Corti
T6409	29114-29119	VBZ	denotes	seems
T6425	29120-29122	TO	denotes	to
T6426	29123-29125	VB	denotes	be
T6427	29126-29132	RB	denotes	rather
T6428	29133-29139	JJ	denotes	normal
T6429	29139-29141	,	denotes	,
T6430	29141-29145	RB	denotes	even
T6431	29146-29148	IN	denotes	in
T6432	29149-29152	DT	denotes	the
T6433	29153-29157	NN	denotes	apex
T6434	29158-29160	IN	denotes	of
T6435	29161-29164	DT	denotes	the
T6436	29165-29172	NN	denotes	cochlea
T6437	29173-29178	WDT	denotes	which
T6439	29179-29183	VBZ	denotes	does
T6440	29184-29187	RB	denotes	not
T6441	29188-29192	RB	denotes	even
T6438	29193-29200	VB	denotes	develop
T6442	29201-29209	JJ	denotes	immature
T6444	29210-29214	NN	denotes	hair
T6443	29215-29220	NNS	denotes	cells
T6445	29221-29233	JJ	denotes	recognizable
T6446	29234-29236	IN	denotes	by
T6447	29237-29240	NNP	denotes	Myo
T6448	29241-29245	NNP	denotes	VIIa
T6449	29245-29246	.	denotes	.
T6450	29246-29390	sentence	denotes	This does not preclude that even less differentiated hair cell precursors may form in the apex or that those precursors have died before birth.
T6451	29247-29251	DT	denotes	This
T6453	29252-29256	VBZ	denotes	does
T6454	29257-29260	RB	denotes	not
T6452	29261-29269	VB	denotes	preclude
T6455	29270-29274	IN	denotes	that
T6457	29275-29279	RB	denotes	even
T6458	29280-29284	RBR	denotes	less
T6459	29285-29299	JJ	denotes	differentiated
T6461	29300-29304	NN	denotes	hair
T6462	29305-29309	NN	denotes	cell
T6460	29310-29320	NNS	denotes	precursors
T6463	29321-29324	MD	denotes	may
T6456	29325-29329	VB	denotes	form
T6464	29330-29332	IN	denotes	in
T6465	29333-29336	DT	denotes	the
T6466	29337-29341	NN	denotes	apex
T6467	29342-29344	CC	denotes	or
T6468	29345-29349	IN	denotes	that
T6470	29350-29355	DT	denotes	those
T6471	29356-29366	NNS	denotes	precursors
T6472	29367-29371	VBP	denotes	have
T6469	29372-29376	VBN	denotes	died
T6473	29377-29383	IN	denotes	before
T6474	29384-29389	NN	denotes	birth
T6475	29389-29390	.	denotes	.
T6476	29390-29484	sentence	denotes	Interestingly, the growth to outer hair cells is most affected in Brn3c null mutant cochleae.
T6477	29391-29404	RB	denotes	Interestingly
T6479	29404-29406	,	denotes	,
T6480	29406-29409	DT	denotes	the
T6481	29410-29416	NN	denotes	growth
T6482	29417-29419	IN	denotes	to
T6483	29420-29425	JJ	denotes	outer
T6485	29426-29430	NN	denotes	hair
T6484	29431-29436	NNS	denotes	cells
T6486	29437-29439	VBZ	denotes	is
T6487	29440-29444	RBS	denotes	most
T6478	29445-29453	VBN	denotes	affected
T6488	29454-29456	IN	denotes	in
T6489	29457-29462	NN	denotes	Brn3c
T6491	29463-29467	JJ	denotes	null
T6492	29468-29474	JJ	denotes	mutant
T6490	29475-29483	NNS	denotes	cochleae
T6493	29483-29484	.	denotes	.
T6494	29484-29665	sentence	denotes	Instead of extending radially through the tunnel of Corti to outer hair cells, afferents appear to stall and extend in longitudinal directions as inner spiral bundles (Figs. 3, 7).
T6495	29485-29492	RB	denotes	Instead
T6496	29493-29495	IN	denotes	of
T6498	29496-29505	VBG	denotes	extending
T6499	29506-29514	RB	denotes	radially
T6500	29515-29522	IN	denotes	through
T6501	29523-29526	DT	denotes	the
T6502	29527-29533	NN	denotes	tunnel
T6503	29534-29536	IN	denotes	of
T6504	29537-29542	NNP	denotes	Corti
T6505	29543-29545	IN	denotes	to
T6506	29546-29551	JJ	denotes	outer
T6508	29552-29556	NN	denotes	hair
T6507	29557-29562	NNS	denotes	cells
T6509	29562-29564	,	denotes	,
T6510	29564-29573	NNS	denotes	afferents
T6497	29574-29580	VBP	denotes	appear
T6511	29581-29583	TO	denotes	to
T6512	29584-29589	VB	denotes	stall
T6513	29590-29593	CC	denotes	and
T6514	29594-29600	VB	denotes	extend
T6515	29601-29603	IN	denotes	in
T6516	29604-29616	JJ	denotes	longitudinal
T6517	29617-29627	NNS	denotes	directions
T6518	29628-29630	IN	denotes	as
T6519	29631-29636	JJ	denotes	inner
T6521	29637-29643	JJ	denotes	spiral
T6520	29644-29651	NNS	denotes	bundles
T6522	29652-29653	-LRB-	denotes	(
T6524	29653-29658	NNS	denotes	Figs.
T6525	29659-29660	CD	denotes	3
T6526	29660-29662	,	denotes	,
T6523	29662-29663	CD	denotes	7
T6527	29663-29664	-RRB-	denotes	)
T6528	29664-29665	.	denotes	.
T6529	29665-29854	sentence	denotes	It has been shown that the differentiation of pillar cells depends on activation of Fgfr3 [26] by FGF's, probably Fgf8, a factor produced by developing and mature inner hair cells [18,27].
T6530	29666-29668	PRP	denotes	It
T6532	29669-29672	VBZ	denotes	has
T6533	29673-29677	VBN	denotes	been
T6531	29678-29683	VBN	denotes	shown
T6534	29684-29688	IN	denotes	that
T6536	29689-29692	DT	denotes	the
T6537	29693-29708	NN	denotes	differentiation
T6538	29709-29711	IN	denotes	of
T6539	29712-29718	JJ	denotes	pillar
T6540	29719-29724	NNS	denotes	cells
T6535	29725-29732	VBZ	denotes	depends
T6541	29733-29735	IN	denotes	on
T6542	29736-29746	NN	denotes	activation
T6543	29747-29749	IN	denotes	of
T6544	29750-29755	NN	denotes	Fgfr3
T6545	29756-29757	-LRB-	denotes	[
T6546	29757-29759	CD	denotes	26
T6547	29759-29760	-RRB-	denotes	]
T6548	29761-29763	IN	denotes	by
T6549	29764-29767	NN	denotes	FGF
T6551	29767-29769	POS	denotes	's
T6552	29769-29771	,	denotes	,
T6553	29771-29779	RB	denotes	probably
T6550	29780-29784	NN	denotes	Fgf8
T6554	29784-29786	,	denotes	,
T6555	29786-29787	DT	denotes	a
T6556	29788-29794	NN	denotes	factor
T6557	29795-29803	VBN	denotes	produced
T6558	29804-29806	IN	denotes	by
T6559	29807-29817	VBG	denotes	developing
T6561	29818-29821	CC	denotes	and
T6562	29822-29828	JJ	denotes	mature
T6563	29829-29834	JJ	denotes	inner
T6564	29835-29839	NN	denotes	hair
T6560	29840-29845	NNS	denotes	cells
T6565	29846-29847	-LRB-	denotes	[
T6567	29847-29849	CD	denotes	18
T6568	29849-29850	,	denotes	,
T6566	29850-29852	CD	denotes	27
T6569	29852-29853	-RRB-	denotes	]
T6570	29853-29854	.	denotes	.
T6571	29854-30052	sentence	denotes	The formation of supporting cells also appears to depend on the proper expression of various bHLH factors such as Hes 1 and 5 which appear to be regulated by the Notch signaling pathway [17,28,29].
T6572	29855-29858	DT	denotes	The
T6573	29859-29868	NN	denotes	formation
T6575	29869-29871	IN	denotes	of
T6576	29872-29882	VBG	denotes	supporting
T6577	29883-29888	NNS	denotes	cells
T6578	29889-29893	RB	denotes	also
T6574	29894-29901	VBZ	denotes	appears
T6579	29902-29904	TO	denotes	to
T6580	29905-29911	VB	denotes	depend
T6581	29912-29914	IN	denotes	on
T6582	29915-29918	DT	denotes	the
T6584	29919-29925	JJ	denotes	proper
T6583	29926-29936	NN	denotes	expression
T6585	29937-29939	IN	denotes	of
T6586	29940-29947	JJ	denotes	various
T6588	29948-29952	JJ	denotes	bHLH
T6587	29953-29960	NNS	denotes	factors
T6589	29961-29965	JJ	denotes	such
T6590	29966-29968	IN	denotes	as
T6591	29969-29972	NNS	denotes	Hes
T6592	29973-29974	CD	denotes	1
T6593	29975-29978	CC	denotes	and
T6594	29979-29980	CD	denotes	5
T6595	29981-29986	WDT	denotes	which
T6596	29987-29993	VBP	denotes	appear
T6597	29994-29996	TO	denotes	to
T6599	29997-29999	VB	denotes	be
T6598	30000-30009	VBN	denotes	regulated
T6600	30010-30012	IN	denotes	by
T6601	30013-30016	DT	denotes	the
T6603	30017-30022	NN	denotes	Notch
T6604	30023-30032	NN	denotes	signaling
T6602	30033-30040	NN	denotes	pathway
T6605	30041-30042	-LRB-	denotes	[
T6607	30042-30044	CD	denotes	17
T6608	30044-30045	,	denotes	,
T6609	30045-30047	CD	denotes	28
T6610	30047-30048	,	denotes	,
T6606	30048-30050	CD	denotes	29
T6611	30050-30051	-RRB-	denotes	]
T6612	30051-30052	.	denotes	.
T6613	30052-30237	sentence	denotes	It is possible that the apparent inability of fibers to extend along outer hair cells is related to the lack of differentiation of supporting cells in the absence of mature hair cells.
T6614	30053-30055	PRP	denotes	It
T6615	30056-30058	VBZ	denotes	is
T6616	30059-30067	JJ	denotes	possible
T6617	30068-30072	IN	denotes	that
T6619	30073-30076	DT	denotes	the
T6621	30077-30085	JJ	denotes	apparent
T6620	30086-30095	NN	denotes	inability
T6622	30096-30098	IN	denotes	of
T6623	30099-30105	NNS	denotes	fibers
T6624	30106-30108	TO	denotes	to
T6625	30109-30115	VB	denotes	extend
T6626	30116-30121	IN	denotes	along
T6627	30122-30127	JJ	denotes	outer
T6629	30128-30132	NN	denotes	hair
T6628	30133-30138	NNS	denotes	cells
T6618	30139-30141	VBZ	denotes	is
T6630	30142-30149	JJ	denotes	related
T6631	30150-30152	IN	denotes	to
T6632	30153-30156	DT	denotes	the
T6633	30157-30161	NN	denotes	lack
T6634	30162-30164	IN	denotes	of
T6635	30165-30180	NN	denotes	differentiation
T6636	30181-30183	IN	denotes	of
T6637	30184-30194	VBG	denotes	supporting
T6638	30195-30200	NNS	denotes	cells
T6639	30201-30203	IN	denotes	in
T6640	30204-30207	DT	denotes	the
T6641	30208-30215	NN	denotes	absence
T6642	30216-30218	IN	denotes	of
T6643	30219-30225	JJ	denotes	mature
T6645	30226-30230	NN	denotes	hair
T6644	30231-30236	NNS	denotes	cells
T6646	30236-30237	.	denotes	.
T6647	30237-30381	sentence	denotes	Probing for the proper expression of supporting cell specific markers in Brn3c null mutants is necessary to further evaluate these suggestions.
T6648	30238-30245	VBG	denotes	Probing
T6650	30246-30249	IN	denotes	for
T6651	30250-30253	DT	denotes	the
T6653	30254-30260	JJ	denotes	proper
T6652	30261-30271	NN	denotes	expression
T6654	30272-30274	IN	denotes	of
T6655	30275-30285	VBG	denotes	supporting
T6657	30286-30290	NN	denotes	cell
T6658	30291-30299	JJ	denotes	specific
T6656	30300-30307	NNS	denotes	markers
T6659	30308-30310	IN	denotes	in
T6660	30311-30316	NN	denotes	Brn3c
T6662	30317-30321	JJ	denotes	null
T6661	30322-30329	NNS	denotes	mutants
T6649	30330-30332	VBZ	denotes	is
T6663	30333-30342	JJ	denotes	necessary
T6664	30343-30345	TO	denotes	to
T6666	30346-30353	RB	denotes	further
T6665	30354-30362	VB	denotes	evaluate
T6667	30363-30368	DT	denotes	these
T6668	30369-30380	NNS	denotes	suggestions
T6669	30380-30381	.	denotes	.
T6670	30381-30582	sentence	denotes	Previous work has suggested that efferent fibers, derived from facial branchial motoneurons, follow afferents and for that reason reflect in detail all connectional deviations of afferents [16,30-32].
T6671	30382-30390	JJ	denotes	Previous
T6672	30391-30395	NN	denotes	work
T6674	30396-30399	VBZ	denotes	has
T6673	30400-30409	VBN	denotes	suggested
T6675	30410-30414	IN	denotes	that
T6677	30415-30423	JJ	denotes	efferent
T6678	30424-30430	NNS	denotes	fibers
T6679	30430-30432	,	denotes	,
T6680	30432-30439	VBN	denotes	derived
T6681	30440-30444	IN	denotes	from
T6682	30445-30451	JJ	denotes	facial
T6684	30452-30461	JJ	denotes	branchial
T6683	30462-30473	NNS	denotes	motoneurons
T6685	30473-30475	,	denotes	,
T6676	30475-30481	VBP	denotes	follow
T6686	30482-30491	NNS	denotes	afferents
T6687	30492-30495	CC	denotes	and
T6688	30496-30499	IN	denotes	for
T6690	30500-30504	DT	denotes	that
T6691	30505-30511	NN	denotes	reason
T6689	30512-30519	VBP	denotes	reflect
T6692	30520-30522	IN	denotes	in
T6693	30523-30529	NN	denotes	detail
T6694	30530-30533	DT	denotes	all
T6696	30534-30546	JJ	denotes	connectional
T6695	30547-30557	NNS	denotes	deviations
T6697	30558-30560	IN	denotes	of
T6698	30561-30570	NNS	denotes	afferents
T6699	30571-30572	-LRB-	denotes	[
T6701	30572-30574	CD	denotes	16
T6702	30574-30575	,	denotes	,
T6703	30575-30577	CD	denotes	30
T6704	30577-30578	HYPH	denotes	-
T6700	30578-30580	CD	denotes	32
T6705	30580-30581	-RRB-	denotes	]
T6706	30581-30582	.	denotes	.
T6707	30582-30631	sentence	denotes	Our data agree with this scenario but extend it.
T6708	30583-30586	PRP$	denotes	Our
T6709	30587-30591	NNS	denotes	data
T6710	30592-30597	VBP	denotes	agree
T6711	30598-30602	IN	denotes	with
T6712	30603-30607	DT	denotes	this
T6713	30608-30616	NN	denotes	scenario
T6714	30617-30620	CC	denotes	but
T6715	30621-30627	VBP	denotes	extend
T6716	30628-30630	PRP	denotes	it
T6717	30630-30631	.	denotes	.
T6718	30631-30822	sentence	denotes	Specifically, efferent fibers may suffer the same loss of their molecularly unknown neurotrophic support as do afferents and therefore show the same spatio-temporal profile of loss (Fig. 3).
T6719	30632-30644	RB	denotes	Specifically
T6721	30644-30646	,	denotes	,
T6722	30646-30654	JJ	denotes	efferent
T6723	30655-30661	NNS	denotes	fibers
T6724	30662-30665	MD	denotes	may
T6720	30666-30672	VB	denotes	suffer
T6725	30673-30676	DT	denotes	the
T6727	30677-30681	JJ	denotes	same
T6726	30682-30686	NN	denotes	loss
T6728	30687-30689	IN	denotes	of
T6729	30690-30695	PRP$	denotes	their
T6731	30696-30707	RB	denotes	molecularly
T6732	30708-30715	JJ	denotes	unknown
T6733	30716-30728	JJ	denotes	neurotrophic
T6730	30729-30736	NN	denotes	support
T6734	30737-30739	IN	denotes	as
T6735	30740-30742	VBP	denotes	do
T6736	30743-30752	NNS	denotes	afferents
T6737	30753-30756	CC	denotes	and
T6738	30757-30766	RB	denotes	therefore
T6739	30767-30771	VBP	denotes	show
T6740	30772-30775	DT	denotes	the
T6742	30776-30780	JJ	denotes	same
T6743	30781-30787	JJ	denotes	spatio
T6745	30787-30788	HYPH	denotes	-
T6744	30788-30796	JJ	denotes	temporal
T6741	30797-30804	NN	denotes	profile
T6746	30805-30807	IN	denotes	of
T6747	30808-30812	NN	denotes	loss
T6748	30813-30814	-LRB-	denotes	(
T6749	30814-30818	NN	denotes	Fig.
T6750	30819-30820	CD	denotes	3
T6751	30820-30821	-RRB-	denotes	)
T6752	30821-30822	.	denotes	.
T6753	30822-30934	sentence	denotes	Alternatively, efferent fibers can sustain established connections only as long as afferent fibers are present.
T6754	30823-30836	RB	denotes	Alternatively
T6756	30836-30838	,	denotes	,
T6757	30838-30846	JJ	denotes	efferent
T6758	30847-30853	NNS	denotes	fibers
T6759	30854-30857	MD	denotes	can
T6755	30858-30865	VB	denotes	sustain
T6760	30866-30877	VBN	denotes	established
T6761	30878-30889	NNS	denotes	connections
T6762	30890-30894	RB	denotes	only
T6764	30895-30897	RB	denotes	as
T6763	30898-30902	RB	denotes	long
T6765	30903-30905	IN	denotes	as
T6767	30906-30914	JJ	denotes	afferent
T6768	30915-30921	NNS	denotes	fibers
T6766	30922-30925	VBP	denotes	are
T6769	30926-30933	JJ	denotes	present
T6770	30933-30934	.	denotes	.
T6771	30934-31076	sentence	denotes	More information on the actual molecular support of efferent fibers in the ear is needed before those two possibilities can be distinguished.
T6772	30935-30939	JJR	denotes	More
T6773	30940-30951	NN	denotes	information
T6775	30952-30954	IN	denotes	on
T6776	30955-30958	DT	denotes	the
T6778	30959-30965	JJ	denotes	actual
T6779	30966-30975	JJ	denotes	molecular
T6777	30976-30983	NN	denotes	support
T6780	30984-30986	IN	denotes	of
T6781	30987-30995	JJ	denotes	efferent
T6782	30996-31002	NNS	denotes	fibers
T6783	31003-31005	IN	denotes	in
T6784	31006-31009	DT	denotes	the
T6785	31010-31013	NN	denotes	ear
T6786	31014-31016	VBZ	denotes	is
T6774	31017-31023	VBN	denotes	needed
T6787	31024-31030	IN	denotes	before
T6789	31031-31036	DT	denotes	those
T6791	31037-31040	CD	denotes	two
T6790	31041-31054	NNS	denotes	possibilities
T6792	31055-31058	MD	denotes	can
T6793	31059-31061	VB	denotes	be
T6788	31062-31075	VBN	denotes	distinguished
T6794	31075-31076	.	denotes	.
T6795	31076-31177	sentence	denotes	The onset of cochleotopic projections has been investigated in detail in only very few mammals [19].
T6796	31077-31080	DT	denotes	The
T6797	31081-31086	NN	denotes	onset
T6799	31087-31089	IN	denotes	of
T6800	31090-31102	JJ	denotes	cochleotopic
T6801	31103-31114	NNS	denotes	projections
T6802	31115-31118	VBZ	denotes	has
T6803	31119-31123	VBN	denotes	been
T6798	31124-31136	VBN	denotes	investigated
T6804	31137-31139	IN	denotes	in
T6805	31140-31146	NN	denotes	detail
T6806	31147-31149	IN	denotes	in
T6807	31150-31154	RB	denotes	only
T6809	31155-31159	RB	denotes	very
T6810	31160-31163	JJ	denotes	few
T6808	31164-31171	NNS	denotes	mammals
T6811	31172-31173	-LRB-	denotes	[
T6812	31173-31175	CD	denotes	19
T6813	31175-31176	-RRB-	denotes	]
T6814	31176-31177	.	denotes	.
T6815	31177-31261	sentence	denotes	These data suggest that a cochleotopic projection develops before onset of hearing.
T6816	31178-31183	DT	denotes	These
T6817	31184-31188	NNS	denotes	data
T6818	31189-31196	VBP	denotes	suggest
T6819	31197-31201	IN	denotes	that
T6821	31202-31203	DT	denotes	a
T6823	31204-31216	JJ	denotes	cochleotopic
T6822	31217-31227	NN	denotes	projection
T6820	31228-31236	VBZ	denotes	develops
T6824	31237-31243	IN	denotes	before
T6825	31244-31249	NN	denotes	onset
T6826	31250-31252	IN	denotes	of
T6827	31253-31260	NN	denotes	hearing
T6828	31260-31261	.	denotes	.
T6829	31261-31408	sentence	denotes	Our data show that at least a cochleotopic projection in the cochlear nerve and the cochlear nuclei develops even in Brn 3c null mutants (Fig. 6).
T6830	31262-31265	PRP$	denotes	Our
T6831	31266-31270	NNS	denotes	data
T6832	31271-31275	VBP	denotes	show
T6833	31276-31280	IN	denotes	that
T6835	31281-31283	RB	denotes	at
T6836	31284-31289	RBS	denotes	least
T6837	31290-31291	DT	denotes	a
T6839	31292-31304	JJ	denotes	cochleotopic
T6838	31305-31315	NN	denotes	projection
T6840	31316-31318	IN	denotes	in
T6841	31319-31322	DT	denotes	the
T6843	31323-31331	JJ	denotes	cochlear
T6842	31332-31337	NN	denotes	nerve
T6844	31338-31341	CC	denotes	and
T6845	31342-31345	DT	denotes	the
T6847	31346-31354	JJ	denotes	cochlear
T6846	31355-31361	NNS	denotes	nuclei
T6834	31362-31370	VBZ	denotes	develops
T6848	31371-31375	RB	denotes	even
T6849	31376-31378	IN	denotes	in
T6850	31379-31382	NNP	denotes	Brn
T6851	31383-31385	NN	denotes	3c
T6853	31386-31390	JJ	denotes	null
T6852	31391-31398	NNS	denotes	mutants
T6854	31399-31400	-LRB-	denotes	(
T6855	31400-31404	NN	denotes	Fig.
T6856	31405-31406	CD	denotes	6
T6857	31406-31407	-RRB-	denotes	)
T6858	31407-31408	.	denotes	.
T6859	31408-31522	sentence	denotes	Those data are also consistent with the formation of a crude cochleotopic projection in NT-3 null mutants [6,14].
T6860	31409-31414	DT	denotes	Those
T6861	31415-31419	NNS	denotes	data
T6862	31420-31423	VBP	denotes	are
T6863	31424-31428	RB	denotes	also
T6864	31429-31439	JJ	denotes	consistent
T6865	31440-31444	IN	denotes	with
T6866	31445-31448	DT	denotes	the
T6867	31449-31458	NN	denotes	formation
T6868	31459-31461	IN	denotes	of
T6869	31462-31463	DT	denotes	a
T6871	31464-31469	JJ	denotes	crude
T6872	31470-31482	JJ	denotes	cochleotopic
T6870	31483-31493	NN	denotes	projection
T6873	31494-31496	IN	denotes	in
T6874	31497-31499	NN	denotes	NT
T6876	31499-31500	HYPH	denotes	-
T6877	31500-31501	CD	denotes	3
T6878	31502-31506	JJ	denotes	null
T6875	31507-31514	NNS	denotes	mutants
T6879	31515-31516	-LRB-	denotes	[
T6881	31516-31517	CD	denotes	6
T6882	31517-31518	,	denotes	,
T6880	31518-31520	CD	denotes	14
T6883	31520-31521	-RRB-	denotes	]
T6884	31521-31522	.	denotes	.
T6885	31522-31683	sentence	denotes	Those mutants have a much more severely reduced density of innervation in the developing cochlea [6,14] than the reduction we found in Brn3c null mutants at P0.
T6886	31523-31528	DT	denotes	Those
T6887	31529-31536	NNS	denotes	mutants
T6888	31537-31541	VBP	denotes	have
T6889	31542-31543	DT	denotes	a
T6891	31544-31548	RB	denotes	much
T6892	31549-31553	RBR	denotes	more
T6893	31554-31562	RB	denotes	severely
T6894	31563-31570	VBN	denotes	reduced
T6890	31571-31578	NN	denotes	density
T6895	31579-31581	IN	denotes	of
T6896	31582-31593	NN	denotes	innervation
T6897	31594-31596	IN	denotes	in
T6898	31597-31600	DT	denotes	the
T6900	31601-31611	VBG	denotes	developing
T6899	31612-31619	NN	denotes	cochlea
T6901	31620-31621	-LRB-	denotes	[
T6903	31621-31622	CD	denotes	6
T6904	31622-31623	,	denotes	,
T6902	31623-31625	CD	denotes	14
T6905	31625-31626	-RRB-	denotes	]
T6906	31627-31631	IN	denotes	than
T6907	31632-31635	DT	denotes	the
T6908	31636-31645	NN	denotes	reduction
T6909	31646-31648	PRP	denotes	we
T6910	31649-31654	VBD	denotes	found
T6911	31655-31657	IN	denotes	in
T6912	31658-31663	NN	denotes	Brn3c
T6914	31664-31668	JJ	denotes	null
T6913	31669-31676	NNS	denotes	mutants
T6915	31677-31679	IN	denotes	at
T6916	31680-31682	NN	denotes	P0
T6917	31682-31683	.	denotes	.
T6918	31683-31928	sentence	denotes	In this context, it would be interesting to see whether the recently generated transgenic mouse in which BDNF is expressed under NT-3 promoter control [33] could actually perform an even more pronounced rescue in a Brn3c null mutant background.
T6919	31684-31686	IN	denotes	In
T6921	31687-31691	DT	denotes	this
T6922	31692-31699	NN	denotes	context
T6923	31699-31701	,	denotes	,
T6924	31701-31703	PRP	denotes	it
T6925	31704-31709	MD	denotes	would
T6920	31710-31712	VB	denotes	be
T6926	31713-31724	JJ	denotes	interesting
T6927	31725-31727	TO	denotes	to
T6928	31728-31731	VB	denotes	see
T6929	31732-31739	IN	denotes	whether
T6931	31740-31743	DT	denotes	the
T6933	31744-31752	RB	denotes	recently
T6934	31753-31762	VBN	denotes	generated
T6935	31763-31773	JJ	denotes	transgenic
T6932	31774-31779	NN	denotes	mouse
T6936	31780-31782	IN	denotes	in
T6938	31783-31788	WDT	denotes	which
T6939	31789-31793	NN	denotes	BDNF
T6940	31794-31796	VBZ	denotes	is
T6937	31797-31806	VBN	denotes	expressed
T6941	31807-31812	IN	denotes	under
T6942	31813-31815	NN	denotes	NT
T6944	31815-31816	HYPH	denotes	-
T6945	31816-31817	CD	denotes	3
T6946	31818-31826	NN	denotes	promoter
T6943	31827-31834	NN	denotes	control
T6947	31835-31836	-LRB-	denotes	[
T6948	31836-31838	CD	denotes	33
T6949	31838-31839	-RRB-	denotes	]
T6950	31840-31845	MD	denotes	could
T6951	31846-31854	RB	denotes	actually
T6930	31855-31862	VB	denotes	perform
T6952	31863-31865	DT	denotes	an
T6954	31866-31870	RB	denotes	even
T6955	31871-31875	RBR	denotes	more
T6956	31876-31886	JJ	denotes	pronounced
T6953	31887-31893	NN	denotes	rescue
T6957	31894-31896	IN	denotes	in
T6958	31897-31898	DT	denotes	a
T6960	31899-31904	NN	denotes	Brn3c
T6961	31905-31909	JJ	denotes	null
T6962	31910-31916	JJ	denotes	mutant
T6959	31917-31927	NN	denotes	background
T6963	31927-31928	.	denotes	.
T7065	31930-31939	NN	denotes	Relevance
T7066	31940-31942	IN	denotes	of
T7067	31943-31946	PRP$	denotes	our
T7068	31947-31955	NNS	denotes	findings
T7069	31956-31958	IN	denotes	to
T7070	31959-31964	JJ	denotes	other
T7071	31965-31974	NNS	denotes	mutations
T7072	31975-31979	IN	denotes	with
T7073	31980-31984	NN	denotes	hair
T7074	31985-31989	NN	denotes	cell
T7075	31990-31994	NN	denotes	loss
T7076	31994-32168	sentence	denotes	Vahava et al. [12] and Frydman et al. [34] have demonstrated that mutation in a single human allele of Pou4f3 (Brn3c) results in a late onset of high frequency hearing loss.
T7077	31995-32001	NNP	denotes	Vahava
T7079	32002-32004	FW	denotes	et
T7080	32005-32008	FW	denotes	al.
T7081	32009-32010	-LRB-	denotes	[
T7082	32010-32012	CD	denotes	12
T7083	32012-32013	-RRB-	denotes	]
T7084	32014-32017	CC	denotes	and
T7085	32018-32025	NNP	denotes	Frydman
T7086	32026-32028	FW	denotes	et
T7087	32029-32032	FW	denotes	al.
T7088	32033-32034	-LRB-	denotes	[
T7089	32034-32036	CD	denotes	34
T7090	32036-32037	-RRB-	denotes	]
T7091	32038-32042	VBP	denotes	have
T7078	32043-32055	VBN	denotes	demonstrated
T7092	32056-32060	IN	denotes	that
T7094	32061-32069	NN	denotes	mutation
T7095	32070-32072	IN	denotes	in
T7096	32073-32074	DT	denotes	a
T7098	32075-32081	JJ	denotes	single
T7099	32082-32087	JJ	denotes	human
T7097	32088-32094	NN	denotes	allele
T7100	32095-32097	IN	denotes	of
T7101	32098-32104	NN	denotes	Pou4f3
T7102	32105-32106	-LRB-	denotes	(
T7103	32106-32111	NN	denotes	Brn3c
T7104	32111-32112	-RRB-	denotes	)
T7093	32113-32120	VBZ	denotes	results
T7105	32121-32123	IN	denotes	in
T7106	32124-32125	DT	denotes	a
T7108	32126-32130	JJ	denotes	late
T7107	32131-32136	NN	denotes	onset
T7109	32137-32139	IN	denotes	of
T7110	32140-32144	JJ	denotes	high
T7111	32145-32154	NN	denotes	frequency
T7113	32155-32162	NN	denotes	hearing
T7112	32163-32167	NN	denotes	loss
T7114	32167-32168	.	denotes	.
T7115	32168-32288	sentence	denotes	Thus far no data are available that correlate the late onset of hearing loss with morphological defects in the cochlea.
T7116	32169-32173	RB	denotes	Thus
T7117	32174-32177	RB	denotes	far
T7119	32178-32180	DT	denotes	no
T7120	32181-32185	NNS	denotes	data
T7118	32186-32189	VBP	denotes	are
T7121	32190-32199	JJ	denotes	available
T7122	32200-32204	WDT	denotes	that
T7123	32205-32214	VBP	denotes	correlate
T7124	32215-32218	DT	denotes	the
T7126	32219-32223	JJ	denotes	late
T7125	32224-32229	NN	denotes	onset
T7127	32230-32232	IN	denotes	of
T7128	32233-32240	NN	denotes	hearing
T7129	32241-32245	NN	denotes	loss
T7130	32246-32250	IN	denotes	with
T7131	32251-32264	JJ	denotes	morphological
T7132	32265-32272	NNS	denotes	defects
T7133	32273-32275	IN	denotes	in
T7134	32276-32279	DT	denotes	the
T7135	32280-32287	NN	denotes	cochlea
T7136	32287-32288	.	denotes	.
T7137	32288-32432	sentence	denotes	In fact, an investigation of Brn3c heterozygotic mice showed no additional effect on hearing loss due to haploinsufficiency in these mice [35].
T7138	32289-32291	IN	denotes	In
T7140	32292-32296	NN	denotes	fact
T7141	32296-32298	,	denotes	,
T7142	32298-32300	DT	denotes	an
T7143	32301-32314	NN	denotes	investigation
T7144	32315-32317	IN	denotes	of
T7145	32318-32323	NN	denotes	Brn3c
T7147	32324-32337	JJ	denotes	heterozygotic
T7146	32338-32342	NNS	denotes	mice
T7139	32343-32349	VBD	denotes	showed
T7148	32350-32352	DT	denotes	no
T7150	32353-32363	JJ	denotes	additional
T7149	32364-32370	NN	denotes	effect
T7151	32371-32373	IN	denotes	on
T7152	32374-32381	NN	denotes	hearing
T7153	32382-32386	NN	denotes	loss
T7154	32387-32390	IN	denotes	due
T7155	32391-32393	IN	denotes	to
T7156	32394-32412	NN	denotes	haploinsufficiency
T7157	32413-32415	IN	denotes	in
T7158	32416-32421	DT	denotes	these
T7159	32422-32426	NNS	denotes	mice
T7160	32427-32428	-LRB-	denotes	[
T7161	32428-32430	CD	denotes	35
T7162	32430-32431	-RRB-	denotes	]
T7163	32431-32432	.	denotes	.
T7164	32432-32656	sentence	denotes	Our data on Brn3c null mouse mutants nevertheless suggest that the high to low frequency progressive hearing loss in humans may correlate with the unknown factor(s) that mediate apical spiral neuron survival into adulthood.
T7165	32433-32436	PRP$	denotes	Our
T7166	32437-32441	NNS	denotes	data
T7168	32442-32444	IN	denotes	on
T7169	32445-32450	NN	denotes	Brn3c
T7171	32451-32455	JJ	denotes	null
T7172	32456-32461	NN	denotes	mouse
T7170	32462-32469	NNS	denotes	mutants
T7173	32470-32482	RB	denotes	nevertheless
T7167	32483-32490	VBP	denotes	suggest
T7174	32491-32495	IN	denotes	that
T7176	32496-32499	DT	denotes	the
T7178	32500-32504	JJ	denotes	high
T7180	32505-32507	IN	denotes	to
T7181	32508-32511	JJ	denotes	low
T7179	32512-32521	NN	denotes	frequency
T7182	32522-32533	JJ	denotes	progressive
T7183	32534-32541	NN	denotes	hearing
T7177	32542-32546	NN	denotes	loss
T7184	32547-32549	IN	denotes	in
T7185	32550-32556	NNS	denotes	humans
T7186	32557-32560	MD	denotes	may
T7175	32561-32570	VB	denotes	correlate
T7187	32571-32575	IN	denotes	with
T7188	32576-32579	DT	denotes	the
T7190	32580-32587	JJ	denotes	unknown
T7189	32588-32594	NN	denotes	factor
T7191	32594-32595	-LRB-	denotes	(
T7192	32595-32596	AFX	denotes	s
T7193	32596-32597	-RRB-	denotes	)
T7194	32598-32602	WDT	denotes	that
T7195	32603-32610	VBP	denotes	mediate
T7196	32611-32617	JJ	denotes	apical
T7198	32618-32624	JJ	denotes	spiral
T7197	32625-32631	NN	denotes	neuron
T7199	32632-32640	NN	denotes	survival
T7200	32641-32645	IN	denotes	into
T7201	32646-32655	NN	denotes	adulthood
T7202	32655-32656	.	denotes	.
T7203	32656-32833	sentence	denotes	Quantitative data on human Pou4f3 cochleae is needed to verify that spiral neuron loss is more pronounced in the basal, high frequency area of these hearing-deficient patients.
T7204	32657-32669	JJ	denotes	Quantitative
T7205	32670-32674	NNS	denotes	data
T7207	32675-32677	IN	denotes	on
T7208	32678-32683	JJ	denotes	human
T7210	32684-32690	NN	denotes	Pou4f3
T7209	32691-32699	NNS	denotes	cochleae
T7211	32700-32702	VBZ	denotes	is
T7206	32703-32709	VBN	denotes	needed
T7212	32710-32712	TO	denotes	to
T7213	32713-32719	VB	denotes	verify
T7214	32720-32724	IN	denotes	that
T7216	32725-32731	JJ	denotes	spiral
T7217	32732-32738	NN	denotes	neuron
T7218	32739-32743	NN	denotes	loss
T7215	32744-32746	VBZ	denotes	is
T7219	32747-32751	RBR	denotes	more
T7220	32752-32762	JJ	denotes	pronounced
T7221	32763-32765	IN	denotes	in
T7222	32766-32769	DT	denotes	the
T7224	32770-32775	JJ	denotes	basal
T7225	32775-32777	,	denotes	,
T7226	32777-32781	JJ	denotes	high
T7227	32782-32791	NN	denotes	frequency
T7223	32792-32796	NN	denotes	area
T7228	32797-32799	IN	denotes	of
T7229	32800-32805	DT	denotes	these
T7231	32806-32813	NN	denotes	hearing
T7233	32813-32814	HYPH	denotes	-
T7232	32814-32823	JJ	denotes	deficient
T7230	32824-32832	NNS	denotes	patients
T7234	32832-32833	.	denotes	.
T7235	32833-32936	sentence	denotes	Similar data are also needed for other congenitally deaf children [36] and in the deaf white cat [25].
T7236	32834-32841	JJ	denotes	Similar
T7237	32842-32846	NNS	denotes	data
T7239	32847-32850	VBP	denotes	are
T7240	32851-32855	RB	denotes	also
T7238	32856-32862	VBN	denotes	needed
T7241	32863-32866	IN	denotes	for
T7242	32867-32872	JJ	denotes	other
T7244	32873-32885	RB	denotes	congenitally
T7245	32886-32890	JJ	denotes	deaf
T7243	32891-32899	NNS	denotes	children
T7246	32900-32901	-LRB-	denotes	[
T7247	32901-32903	CD	denotes	36
T7248	32903-32904	-RRB-	denotes	]
T7249	32905-32908	CC	denotes	and
T7250	32909-32911	IN	denotes	in
T7251	32912-32915	DT	denotes	the
T7253	32916-32920	NN	denotes	deaf
T7254	32921-32926	JJ	denotes	white
T7252	32927-32930	NN	denotes	cat
T7255	32931-32932	-LRB-	denotes	[
T7256	32932-32934	CD	denotes	25
T7257	32934-32935	-RRB-	denotes	]
T7258	32935-32936	.	denotes	.
T7259	32936-33215	sentence	denotes	Further work on the recently available mutant mice with specific absence of all hair cells [37], outer hair cells in the base [38] or apex [39] could further help to clarify the role of hair cells in forming and maintaining afferent and efferent innervation in these model mice.
T7260	32937-32944	JJ	denotes	Further
T7261	32945-32949	NN	denotes	work
T7263	32950-32952	IN	denotes	on
T7264	32953-32956	DT	denotes	the
T7266	32957-32965	RB	denotes	recently
T7267	32966-32975	JJ	denotes	available
T7268	32976-32982	JJ	denotes	mutant
T7265	32983-32987	NNS	denotes	mice
T7269	32988-32992	IN	denotes	with
T7270	32993-33001	JJ	denotes	specific
T7271	33002-33009	NN	denotes	absence
T7272	33010-33012	IN	denotes	of
T7273	33013-33016	DT	denotes	all
T7275	33017-33021	NN	denotes	hair
T7274	33022-33027	NNS	denotes	cells
T7276	33028-33029	-LRB-	denotes	[
T7277	33029-33031	CD	denotes	37
T7278	33031-33032	-RRB-	denotes	]
T7279	33032-33034	,	denotes	,
T7280	33034-33039	JJ	denotes	outer
T7282	33040-33044	NN	denotes	hair
T7281	33045-33050	NNS	denotes	cells
T7283	33051-33053	IN	denotes	in
T7284	33054-33057	DT	denotes	the
T7285	33058-33062	NN	denotes	base
T7286	33063-33064	-LRB-	denotes	[
T7287	33064-33066	CD	denotes	38
T7288	33066-33067	-RRB-	denotes	]
T7289	33068-33070	CC	denotes	or
T7290	33071-33075	NN	denotes	apex
T7291	33076-33077	-LRB-	denotes	[
T7292	33077-33079	CD	denotes	39
T7293	33079-33080	-RRB-	denotes	]
T7294	33081-33086	MD	denotes	could
T7295	33087-33094	RB	denotes	further
T7262	33095-33099	VB	denotes	help
T7296	33100-33102	TO	denotes	to
T7297	33103-33110	VB	denotes	clarify
T7298	33111-33114	DT	denotes	the
T7299	33115-33119	NN	denotes	role
T7300	33120-33122	IN	denotes	of
T7301	33123-33127	NN	denotes	hair
T7302	33128-33133	NNS	denotes	cells
T7303	33134-33136	IN	denotes	in
T7304	33137-33144	VBG	denotes	forming
T7305	33145-33148	CC	denotes	and
T7306	33149-33160	VBG	denotes	maintaining
T7307	33161-33169	JJ	denotes	afferent
T7309	33170-33173	CC	denotes	and
T7310	33174-33182	JJ	denotes	efferent
T7308	33183-33194	NN	denotes	innervation
T7311	33195-33197	IN	denotes	in
T7312	33198-33203	DT	denotes	these
T7314	33204-33209	NN	denotes	model
T7313	33210-33214	NNS	denotes	mice
T7315	33214-33215	.	denotes	.
T7403	33228-33231	DT	denotes	The
T7405	33232-33243	JJ	denotes	progressive
T7404	33244-33248	NN	denotes	loss
T7407	33249-33251	IN	denotes	of
T7408	33252-33260	JJ	denotes	afferent
T7410	33261-33264	CC	denotes	and
T7411	33265-33273	JJ	denotes	efferent
T7409	33274-33285	NN	denotes	innervation
T7412	33286-33288	IN	denotes	in
T7413	33289-33294	NN	denotes	Brn3c
T7414	33295-33299	JJ	denotes	null
T7415	33300-33307	NNS	denotes	mutants
T7406	33308-33313	VBZ	denotes	shows
T7416	33314-33321	CC	denotes	neither
T7417	33322-33324	IN	denotes	in
T7418	33325-33332	JJ	denotes	spatial
T7419	33333-33336	CC	denotes	nor
T7420	33337-33339	IN	denotes	in
T7421	33340-33348	JJ	denotes	temporal
T7422	33349-33356	NN	denotes	pattern
T7423	33357-33358	DT	denotes	a
T7424	33359-33370	NN	denotes	resemblance
T7425	33371-33373	IN	denotes	to
T7426	33374-33380	NNS	denotes	losses
T7427	33381-33389	VBN	denotes	reported
T7428	33390-33392	IN	denotes	in
T7429	33393-33399	JJ	denotes	simple
T7430	33400-33404	NN	denotes	BDNF
T7431	33405-33407	CC	denotes	or
T7432	33408-33410	NN	denotes	NT
T7434	33410-33411	HYPH	denotes	-
T7435	33411-33412	CD	denotes	3
T7436	33413-33417	JJ	denotes	null
T7433	33418-33427	NNS	denotes	mutations
T7437	33428-33429	-LRB-	denotes	[
T7438	33429-33430	CD	denotes	6
T7439	33430-33431	-RRB-	denotes	]
T7440	33431-33432	.	denotes	.
T7441	33432-33532	sentence	denotes	Null mutants of ear specific neurotrophins have completed the loss of sensory neurons before birth.
T7442	33433-33437	JJ	denotes	Null
T7443	33438-33445	NNS	denotes	mutants
T7445	33446-33448	IN	denotes	of
T7446	33449-33452	NN	denotes	ear
T7447	33453-33461	JJ	denotes	specific
T7448	33462-33475	NNS	denotes	neurotrophins
T7449	33476-33480	VBP	denotes	have
T7444	33481-33490	VBN	denotes	completed
T7450	33491-33494	DT	denotes	the
T7451	33495-33499	NN	denotes	loss
T7452	33500-33502	IN	denotes	of
T7453	33503-33510	JJ	denotes	sensory
T7454	33511-33518	NNS	denotes	neurons
T7455	33519-33525	IN	denotes	before
T7456	33526-33531	NN	denotes	birth
T7457	33531-33532	.	denotes	.
T7458	33532-33648	sentence	denotes	In contrast, our results suggest a slow loss of afferent and efferent innervation between P0 and at least 6 months.
T7459	33533-33535	IN	denotes	In
T7461	33536-33544	NN	denotes	contrast
T7462	33544-33546	,	denotes	,
T7463	33546-33549	PRP$	denotes	our
T7464	33550-33557	NNS	denotes	results
T7460	33558-33565	VBP	denotes	suggest
T7465	33566-33567	DT	denotes	a
T7467	33568-33572	JJ	denotes	slow
T7466	33573-33577	NN	denotes	loss
T7468	33578-33580	IN	denotes	of
T7469	33581-33589	JJ	denotes	afferent
T7471	33590-33593	CC	denotes	and
T7472	33594-33602	JJ	denotes	efferent
T7470	33603-33614	NN	denotes	innervation
T7473	33615-33622	IN	denotes	between
T7474	33623-33625	NN	denotes	P0
T7475	33626-33629	CC	denotes	and
T7476	33630-33632	RB	denotes	at
T7477	33633-33638	RBS	denotes	least
T7479	33639-33640	CD	denotes	6
T7478	33641-33647	NNS	denotes	months
T7480	33647-33648	.	denotes	.
T7481	33648-33784	sentence	denotes	This late sensory neuron loss is likely not related to known neurotrophin signaling which becomes reduced in neonatal wildtype animals.
T7482	33649-33653	DT	denotes	This
T7484	33654-33658	JJ	denotes	late
T7485	33659-33666	JJ	denotes	sensory
T7486	33667-33673	NN	denotes	neuron
T7483	33674-33678	NN	denotes	loss
T7487	33679-33681	VBZ	denotes	is
T7488	33682-33688	RB	denotes	likely
T7489	33689-33692	RB	denotes	not
T7490	33693-33700	JJ	denotes	related
T7491	33701-33703	IN	denotes	to
T7492	33704-33709	JJ	denotes	known
T7494	33710-33722	NN	denotes	neurotrophin
T7493	33723-33732	NN	denotes	signaling
T7495	33733-33738	WDT	denotes	which
T7496	33739-33746	VBZ	denotes	becomes
T7497	33747-33754	JJ	denotes	reduced
T7498	33755-33757	IN	denotes	in
T7499	33758-33766	JJ	denotes	neonatal
T7501	33767-33775	JJ	denotes	wildtype
T7500	33776-33783	NNS	denotes	animals
T7502	33783-33784	.	denotes	.
T7503	33784-33965	sentence	denotes	Other factors, such as GDNF [11,40] need to be investigated in their expression in these mutants and their functional role needs to be assessed, in particular in the cochlear apex.
T7504	33785-33790	JJ	denotes	Other
T7505	33791-33798	NNS	denotes	factors
T7507	33798-33800	,	denotes	,
T7508	33800-33804	JJ	denotes	such
T7509	33805-33807	IN	denotes	as
T7510	33808-33812	NN	denotes	GDNF
T7511	33813-33814	-LRB-	denotes	[
T7513	33814-33816	CD	denotes	11
T7514	33816-33817	,	denotes	,
T7512	33817-33819	CD	denotes	40
T7515	33819-33820	-RRB-	denotes	]
T7506	33821-33825	VBP	denotes	need
T7516	33826-33828	TO	denotes	to
T7518	33829-33831	VB	denotes	be
T7517	33832-33844	VBN	denotes	investigated
T7519	33845-33847	IN	denotes	in
T7520	33848-33853	PRP$	denotes	their
T7521	33854-33864	NN	denotes	expression
T7522	33865-33867	IN	denotes	in
T7523	33868-33873	DT	denotes	these
T7524	33874-33881	NNS	denotes	mutants
T7525	33882-33885	CC	denotes	and
T7526	33886-33891	PRP$	denotes	their
T7528	33892-33902	JJ	denotes	functional
T7527	33903-33907	NN	denotes	role
T7529	33908-33913	VBZ	denotes	needs
T7530	33914-33916	TO	denotes	to
T7532	33917-33919	VB	denotes	be
T7531	33920-33928	VBN	denotes	assessed
T7533	33928-33930	,	denotes	,
T7534	33930-33932	IN	denotes	in
T7536	33933-33943	JJ	denotes	particular
T7535	33944-33946	IN	denotes	in
T7537	33947-33950	DT	denotes	the
T7539	33951-33959	JJ	denotes	cochlear
T7538	33960-33964	NN	denotes	apex
T7540	33964-33965	.	denotes	.
T7541	33965-34142	sentence	denotes	The long term retention of afferents in the cochlear apex in the absence of any apparent differentiation of hair cells raises hopes for cochlear implants in deaf-born children.
T7542	33966-33969	DT	denotes	The
T7544	33970-33974	JJ	denotes	long
T7545	33975-33979	NN	denotes	term
T7543	33980-33989	NN	denotes	retention
T7547	33990-33992	IN	denotes	of
T7548	33993-34002	NNS	denotes	afferents
T7549	34003-34005	IN	denotes	in
T7550	34006-34009	DT	denotes	the
T7552	34010-34018	JJ	denotes	cochlear
T7551	34019-34023	NN	denotes	apex
T7553	34024-34026	IN	denotes	in
T7554	34027-34030	DT	denotes	the
T7555	34031-34038	NN	denotes	absence
T7556	34039-34041	IN	denotes	of
T7557	34042-34045	DT	denotes	any
T7559	34046-34054	JJ	denotes	apparent
T7558	34055-34070	NN	denotes	differentiation
T7560	34071-34073	IN	denotes	of
T7561	34074-34078	NN	denotes	hair
T7562	34079-34084	NNS	denotes	cells
T7546	34085-34091	VBZ	denotes	raises
T7563	34092-34097	NNS	denotes	hopes
T7564	34098-34101	IN	denotes	for
T7565	34102-34110	JJ	denotes	cochlear
T7566	34111-34119	NNS	denotes	implants
T7567	34120-34122	IN	denotes	in
T7568	34123-34127	JJ	denotes	deaf
T7570	34127-34128	HYPH	denotes	-
T7569	34128-34132	VBN	denotes	born
T7571	34133-34141	NNS	denotes	children
T7572	34141-34142	.	denotes	.
T7573	34142-34322	sentence	denotes	Similar long term retention of apical afferents exists in the deaf white cat [25] and should be explored in other model systems with embryonic and neonatal hair cell loss [37,38].
T7574	34143-34150	JJ	denotes	Similar
T7576	34151-34155	JJ	denotes	long
T7577	34156-34160	NN	denotes	term
T7575	34161-34170	NN	denotes	retention
T7579	34171-34173	IN	denotes	of
T7580	34174-34180	JJ	denotes	apical
T7581	34181-34190	NNS	denotes	afferents
T7578	34191-34197	VBZ	denotes	exists
T7582	34198-34200	IN	denotes	in
T7583	34201-34204	DT	denotes	the
T7585	34205-34209	NN	denotes	deaf
T7586	34210-34215	JJ	denotes	white
T7584	34216-34219	NN	denotes	cat
T7587	34220-34221	-LRB-	denotes	[
T7588	34221-34223	CD	denotes	25
T7589	34223-34224	-RRB-	denotes	]
T7590	34225-34228	CC	denotes	and
T7591	34229-34235	MD	denotes	should
T7593	34236-34238	VB	denotes	be
T7592	34239-34247	VBN	denotes	explored
T7594	34248-34250	IN	denotes	in
T7595	34251-34256	JJ	denotes	other
T7597	34257-34262	NN	denotes	model
T7596	34263-34270	NNS	denotes	systems
T7598	34271-34275	IN	denotes	with
T7599	34276-34285	JJ	denotes	embryonic
T7601	34286-34289	CC	denotes	and
T7602	34290-34298	JJ	denotes	neonatal
T7603	34299-34303	NN	denotes	hair
T7604	34304-34308	NN	denotes	cell
T7600	34309-34313	NN	denotes	loss
T7605	34314-34315	-LRB-	denotes	[
T7607	34315-34317	CD	denotes	37
T7608	34317-34318	,	denotes	,
T7606	34318-34320	CD	denotes	38
T7609	34320-34321	-RRB-	denotes	]
T7610	34321-34322	.	denotes	.
T7649	34333-34341	NN	denotes	Breeding
T7650	34342-34345	CC	denotes	and
T7651	34346-34356	NN	denotes	genotyping
T7652	34356-34407	sentence	denotes	Brn3c mice were bred as previously described [22].
T7653	34357-34362	NN	denotes	Brn3c
T7654	34363-34367	NNS	denotes	mice
T7656	34368-34372	VBD	denotes	were
T7655	34373-34377	VBN	denotes	bred
T7657	34378-34380	IN	denotes	as
T7659	34381-34391	RB	denotes	previously
T7658	34392-34401	VBN	denotes	described
T7660	34402-34403	-LRB-	denotes	[
T7661	34403-34405	CD	denotes	22
T7662	34405-34406	-RRB-	denotes	]
T7663	34406-34407	.	denotes	.
T7664	34407-34536	sentence	denotes	Mice were genotyped and Brn3c null mutants were raised to a specific age (P0, N = 8; P7, N = 6; P8, N = 6; 6 months old, N = 2).
T7665	34408-34412	NNS	denotes	Mice
T7667	34413-34417	VBD	denotes	were
T7666	34418-34427	VBN	denotes	genotyped
T7668	34428-34431	CC	denotes	and
T7669	34432-34437	NN	denotes	Brn3c
T7671	34438-34442	JJ	denotes	null
T7670	34443-34450	NNS	denotes	mutants
T7673	34451-34455	VBD	denotes	were
T7672	34456-34462	VBN	denotes	raised
T7674	34463-34465	IN	denotes	to
T7675	34466-34467	DT	denotes	a
T7677	34468-34476	JJ	denotes	specific
T7676	34477-34480	NN	denotes	age
T7678	34481-34482	-LRB-	denotes	(
T7680	34482-34484	NN	denotes	P0
T7682	34484-34486	,	denotes	,
T7683	34486-34487	NN	denotes	N
T7684	34488-34489	SYM	denotes	=
T7681	34490-34491	CD	denotes	8
T7685	34491-34492	:	denotes	;
T7686	34493-34495	NN	denotes	P7
T7688	34495-34497	,	denotes	,
T7689	34497-34498	NN	denotes	N
T7690	34499-34500	SYM	denotes	=
T7687	34501-34502	CD	denotes	6
T7691	34502-34503	:	denotes	;
T7692	34504-34506	NN	denotes	P8
T7694	34506-34508	,	denotes	,
T7695	34508-34509	NN	denotes	N
T7696	34510-34511	SYM	denotes	=
T7693	34512-34513	CD	denotes	6
T7697	34513-34514	:	denotes	;
T7698	34515-34516	CD	denotes	6
T7699	34517-34523	NNS	denotes	months
T7700	34524-34527	JJ	denotes	old
T7701	34527-34529	,	denotes	,
T7702	34529-34530	NN	denotes	N
T7703	34531-34532	SYM	denotes	=
T7679	34533-34534	CD	denotes	2
T7704	34534-34535	-RRB-	denotes	)
T7705	34535-34536	.	denotes	.
T7706	34536-34681	sentence	denotes	The animals were deeply anesthetized with pentobarbital and transcardially perfused with 4% paraformaldehyde in 0.1 M phosphate buffer (pH 7.4).
T7707	34537-34540	DT	denotes	The
T7708	34541-34548	NNS	denotes	animals
T7710	34549-34553	VBD	denotes	were
T7711	34554-34560	RB	denotes	deeply
T7709	34561-34573	VBN	denotes	anesthetized
T7712	34574-34578	IN	denotes	with
T7713	34579-34592	NN	denotes	pentobarbital
T7714	34593-34596	CC	denotes	and
T7715	34597-34611	RB	denotes	transcardially
T7716	34612-34620	VBN	denotes	perfused
T7717	34621-34625	IN	denotes	with
T7718	34626-34627	CD	denotes	4
T7719	34627-34628	NN	denotes	%
T7720	34629-34645	NN	denotes	paraformaldehyde
T7721	34646-34648	IN	denotes	in
T7722	34649-34652	CD	denotes	0.1
T7723	34653-34654	NN	denotes	M
T7725	34655-34664	NN	denotes	phosphate
T7724	34665-34671	NN	denotes	buffer
T7726	34672-34673	-LRB-	denotes	(
T7727	34673-34675	NN	denotes	pH
T7728	34676-34679	CD	denotes	7.4
T7729	34679-34680	-RRB-	denotes	)
T7730	34680-34681	.	denotes	.
T7731	34681-34764	sentence	denotes	Ears were postfixed in the same fixative for at least one day prior to dissection.
T7732	34682-34686	NNS	denotes	Ears
T7734	34687-34691	VBD	denotes	were
T7733	34692-34701	VBN	denotes	postfixed
T7735	34702-34704	IN	denotes	in
T7736	34705-34708	DT	denotes	the
T7738	34709-34713	JJ	denotes	same
T7737	34714-34722	JJ	denotes	fixative
T7739	34723-34726	IN	denotes	for
T7740	34727-34729	RB	denotes	at
T7742	34730-34735	RBS	denotes	least
T7741	34736-34739	CD	denotes	one
T7743	34740-34743	NN	denotes	day
T7744	34744-34749	JJ	denotes	prior
T7745	34750-34752	IN	denotes	to
T7746	34753-34763	NN	denotes	dissection
T7747	34763-34764	.	denotes	.
T7827	34766-34773	NN	denotes	Tracing
T7828	34774-34776	IN	denotes	of
T7829	34777-34782	NN	denotes	nerve
T7830	34783-34789	NNS	denotes	fibers
T7831	34789-34864	sentence	denotes	DiI tracing from the brainstem was performed as previously described [41].
T7832	34790-34793	NN	denotes	DiI
T7834	34794-34801	VBG	denotes	tracing
T7835	34802-34806	IN	denotes	from
T7836	34807-34810	DT	denotes	the
T7837	34811-34820	NN	denotes	brainstem
T7838	34821-34824	VBD	denotes	was
T7833	34825-34834	VBN	denotes	performed
T7839	34835-34837	IN	denotes	as
T7841	34838-34848	RB	denotes	previously
T7840	34849-34858	VBN	denotes	described
T7842	34859-34860	-LRB-	denotes	[
T7843	34860-34862	CD	denotes	41
T7844	34862-34863	-RRB-	denotes	]
T7845	34863-34864	.	denotes	.
T7846	34864-35048	sentence	denotes	Small filter stripes soaked with saturated DiI were implanted into the efferent fiber bundle near the floor plate or into the ascending or descending afferents in the alar plate [42].
T7847	34865-34870	JJ	denotes	Small
T7849	34871-34877	NN	denotes	filter
T7848	34878-34885	NNS	denotes	stripes
T7851	34886-34892	VBN	denotes	soaked
T7852	34893-34897	IN	denotes	with
T7853	34898-34907	VBN	denotes	saturated
T7854	34908-34911	NN	denotes	DiI
T7855	34912-34916	VBD	denotes	were
T7850	34917-34926	VBN	denotes	implanted
T7856	34927-34931	IN	denotes	into
T7857	34932-34935	DT	denotes	the
T7859	34936-34944	JJ	denotes	efferent
T7860	34945-34950	NN	denotes	fiber
T7858	34951-34957	NN	denotes	bundle
T7861	34958-34962	IN	denotes	near
T7862	34963-34966	DT	denotes	the
T7864	34967-34972	NN	denotes	floor
T7863	34973-34978	NN	denotes	plate
T7865	34979-34981	CC	denotes	or
T7866	34982-34986	IN	denotes	into
T7867	34987-34990	DT	denotes	the
T7869	34991-35000	VBG	denotes	ascending
T7870	35001-35003	CC	denotes	or
T7871	35004-35014	VBG	denotes	descending
T7868	35015-35024	NNS	denotes	afferents
T7872	35025-35027	IN	denotes	in
T7873	35028-35031	DT	denotes	the
T7875	35032-35036	JJ	denotes	alar
T7874	35037-35042	NN	denotes	plate
T7876	35043-35044	-LRB-	denotes	[
T7877	35044-35046	CD	denotes	42
T7878	35046-35047	-RRB-	denotes	]
T7879	35047-35048	.	denotes	.
T7880	35048-35185	sentence	denotes	After appropriate diffusion time of the dye, the ears were dissected and mounted flat for visualization in an epifluorescent microscope.
T7881	35049-35054	IN	denotes	After
T7883	35055-35066	JJ	denotes	appropriate
T7885	35067-35076	NN	denotes	diffusion
T7884	35077-35081	NN	denotes	time
T7886	35082-35084	IN	denotes	of
T7887	35085-35088	DT	denotes	the
T7888	35089-35092	NN	denotes	dye
T7889	35092-35094	,	denotes	,
T7890	35094-35097	DT	denotes	the
T7891	35098-35102	NNS	denotes	ears
T7892	35103-35107	VBD	denotes	were
T7882	35108-35117	VBN	denotes	dissected
T7893	35118-35121	CC	denotes	and
T7894	35122-35129	VBN	denotes	mounted
T7895	35130-35134	JJ	denotes	flat
T7896	35135-35138	IN	denotes	for
T7897	35139-35152	NN	denotes	visualization
T7898	35153-35155	IN	denotes	in
T7899	35156-35158	DT	denotes	an
T7901	35159-35173	JJ	denotes	epifluorescent
T7900	35174-35184	NN	denotes	microscope
T7902	35184-35185	.	denotes	.
T7903	35185-35323	sentence	denotes	Images were taken on black and white film or acquired with a cooled CCD camera and processed using ImagePro software (Media Cybernetics).
T7904	35186-35192	NNS	denotes	Images
T7906	35193-35197	VBD	denotes	were
T7905	35198-35203	VBN	denotes	taken
T7907	35204-35206	IN	denotes	on
T7908	35207-35212	JJ	denotes	black
T7910	35213-35216	CC	denotes	and
T7911	35217-35222	JJ	denotes	white
T7909	35223-35227	NN	denotes	film
T7912	35228-35230	CC	denotes	or
T7913	35231-35239	VBN	denotes	acquired
T7914	35240-35244	IN	denotes	with
T7915	35245-35246	DT	denotes	a
T7917	35247-35253	VBN	denotes	cooled
T7918	35254-35257	NN	denotes	CCD
T7916	35258-35264	NN	denotes	camera
T7919	35265-35268	CC	denotes	and
T7920	35269-35278	VBN	denotes	processed
T7921	35279-35284	VBG	denotes	using
T7922	35285-35293	NN	denotes	ImagePro
T7923	35294-35302	NN	denotes	software
T7924	35303-35304	-LRB-	denotes	(
T7926	35304-35309	NNPS	denotes	Media
T7925	35310-35321	NNP	denotes	Cybernetics
T7927	35321-35322	-RRB-	denotes	)
T7928	35322-35323	.	denotes	.
T7929	35323-35502	sentence	denotes	Ears were subsequently reacted for acetylated tubulin to reveal the pattern of innervation in addition to the DiI tracing with a different technique as previously described [14].
T7930	35324-35328	NNS	denotes	Ears
T7932	35329-35333	VBD	denotes	were
T7933	35334-35346	RB	denotes	subsequently
T7931	35347-35354	VBN	denotes	reacted
T7934	35355-35358	IN	denotes	for
T7935	35359-35369	VBN	denotes	acetylated
T7936	35370-35377	NN	denotes	tubulin
T7937	35378-35380	TO	denotes	to
T7938	35381-35387	VB	denotes	reveal
T7939	35388-35391	DT	denotes	the
T7940	35392-35399	NN	denotes	pattern
T7941	35400-35402	IN	denotes	of
T7942	35403-35414	NN	denotes	innervation
T7943	35415-35417	IN	denotes	in
T7944	35418-35426	NN	denotes	addition
T7945	35427-35429	IN	denotes	to
T7946	35430-35433	DT	denotes	the
T7947	35434-35437	NN	denotes	DiI
T7948	35438-35445	VBG	denotes	tracing
T7949	35446-35450	IN	denotes	with
T7950	35451-35452	DT	denotes	a
T7952	35453-35462	JJ	denotes	different
T7951	35463-35472	NN	denotes	technique
T7953	35473-35475	IN	denotes	as
T7955	35476-35486	RB	denotes	previously
T7954	35487-35496	VBN	denotes	described
T7956	35497-35498	-LRB-	denotes	[
T7957	35498-35500	CD	denotes	14
T7958	35500-35501	-RRB-	denotes	]
T7959	35501-35502	.	denotes	.
T7960	35502-35658	sentence	denotes	Briefly, dissected ears were incubated with 1:500 anti-acetylated tubulin antibodies (Sigma, St. Louis) followed by secondary antibodies conjugated to HRP.
T7961	35503-35510	RB	denotes	Briefly
T7963	35510-35512	,	denotes	,
T7964	35512-35521	VBN	denotes	dissected
T7965	35522-35526	NNS	denotes	ears
T7966	35527-35531	VBD	denotes	were
T7962	35532-35541	VBN	denotes	incubated
T7967	35542-35546	IN	denotes	with
T7968	35547-35548	CD	denotes	1
T7970	35548-35549	SYM	denotes	:
T7969	35549-35552	CD	denotes	500
T7972	35553-35568	JJ	denotes	anti-acetylated
T7973	35569-35576	NN	denotes	tubulin
T7971	35577-35587	NNS	denotes	antibodies
T7974	35588-35589	-LRB-	denotes	(
T7975	35589-35594	NNP	denotes	Sigma
T7976	35594-35596	,	denotes	,
T7977	35596-35599	NNP	denotes	St.
T7978	35600-35605	NNP	denotes	Louis
T7979	35605-35606	-RRB-	denotes	)
T7980	35607-35615	VBN	denotes	followed
T7981	35616-35618	IN	denotes	by
T7982	35619-35628	JJ	denotes	secondary
T7983	35629-35639	NNS	denotes	antibodies
T7984	35640-35650	VBN	denotes	conjugated
T7985	35651-35653	IN	denotes	to
T7986	35654-35657	NN	denotes	HRP
T7987	35657-35658	.	denotes	.
T7988	35658-35772	sentence	denotes	Dissected inner ears were reacted with DAB and H2O2 for HRP distribution and subsequently viewed as whole mounts.
T7989	35659-35668	VBN	denotes	Dissected
T7991	35669-35674	JJ	denotes	inner
T7990	35675-35679	NNS	denotes	ears
T7993	35680-35684	VBD	denotes	were
T7992	35685-35692	VBN	denotes	reacted
T7994	35693-35697	IN	denotes	with
T7995	35698-35701	NN	denotes	DAB
T7996	35702-35705	CC	denotes	and
T7997	35706-35710	NN	denotes	H2O2
T7998	35711-35714	IN	denotes	for
T7999	35715-35718	NN	denotes	HRP
T8000	35719-35731	NN	denotes	distribution
T8001	35732-35735	CC	denotes	and
T8002	35736-35748	RB	denotes	subsequently
T8003	35749-35755	VBN	denotes	viewed
T8004	35756-35758	IN	denotes	as
T8005	35759-35764	JJ	denotes	whole
T8006	35765-35771	NNS	denotes	mounts
T8007	35771-35772	.	denotes	.
T8008	35772-35943	sentence	denotes	After photographing as whole mounts, the ears were embedded in epoxy resin and sectioned to reveal the distribution of fibers inside the sensory epithelia in more detail.
T8009	35773-35778	IN	denotes	After
T8011	35779-35792	VBG	denotes	photographing
T8012	35793-35795	IN	denotes	as
T8013	35796-35801	JJ	denotes	whole
T8014	35802-35808	NNS	denotes	mounts
T8015	35808-35810	,	denotes	,
T8016	35810-35813	DT	denotes	the
T8017	35814-35818	NNS	denotes	ears
T8018	35819-35823	VBD	denotes	were
T8010	35824-35832	VBN	denotes	embedded
T8019	35833-35835	IN	denotes	in
T8020	35836-35841	NN	denotes	epoxy
T8021	35842-35847	NN	denotes	resin
T8022	35848-35851	CC	denotes	and
T8023	35852-35861	VBN	denotes	sectioned
T8024	35862-35864	TO	denotes	to
T8025	35865-35871	VB	denotes	reveal
T8026	35872-35875	DT	denotes	the
T8027	35876-35888	NN	denotes	distribution
T8028	35889-35891	IN	denotes	of
T8029	35892-35898	NNS	denotes	fibers
T8030	35899-35905	IN	denotes	inside
T8031	35906-35909	DT	denotes	the
T8033	35910-35917	JJ	denotes	sensory
T8032	35918-35927	NNS	denotes	epithelia
T8034	35928-35930	IN	denotes	in
T8035	35931-35935	JJR	denotes	more
T8036	35936-35942	NN	denotes	detail
T8037	35942-35943	.	denotes	.
T8038	35943-36165	sentence	denotes	Cochleotopic projection was evaluated by inserting DiI soaked filter strips into the base and DiA soaked filter strips into the apical turn of 2 P0 and 4 P8 Brn3c null mutants and a similar number of wildtype littermates.
T8039	35944-35956	JJ	denotes	Cochleotopic
T8040	35957-35967	NN	denotes	projection
T8042	35968-35971	VBD	denotes	was
T8041	35972-35981	VBN	denotes	evaluated
T8043	35982-35984	IN	denotes	by
T8044	35985-35994	VBG	denotes	inserting
T8045	35995-35998	NN	denotes	DiI
T8046	35999-36005	VBN	denotes	soaked
T8048	36006-36012	NN	denotes	filter
T8047	36013-36019	NNS	denotes	strips
T8049	36020-36024	IN	denotes	into
T8050	36025-36028	DT	denotes	the
T8051	36029-36033	NN	denotes	base
T8052	36034-36037	CC	denotes	and
T8053	36038-36041	NN	denotes	DiA
T8054	36042-36048	VBN	denotes	soaked
T8056	36049-36055	NN	denotes	filter
T8055	36056-36062	NNS	denotes	strips
T8057	36063-36067	IN	denotes	into
T8058	36068-36071	DT	denotes	the
T8060	36072-36078	JJ	denotes	apical
T8059	36079-36083	NN	denotes	turn
T8061	36084-36086	IN	denotes	of
T8062	36087-36088	CD	denotes	2
T8063	36089-36091	NN	denotes	P0
T8064	36092-36095	CC	denotes	and
T8065	36096-36097	CD	denotes	4
T8066	36098-36100	NN	denotes	P8
T8068	36101-36106	NN	denotes	Brn3c
T8069	36107-36111	JJ	denotes	null
T8067	36112-36119	NNS	denotes	mutants
T8070	36120-36123	CC	denotes	and
T8071	36124-36125	DT	denotes	a
T8073	36126-36133	JJ	denotes	similar
T8072	36134-36140	NN	denotes	number
T8074	36141-36143	IN	denotes	of
T8075	36144-36152	JJ	denotes	wildtype
T8076	36153-36164	NNS	denotes	littermates
T8077	36164-36165	.	denotes	.
T8078	36165-36458	sentence	denotes	After appropriate diffusion time [43], the brains with the attached cochlear nerve were embedded in gelatin, hardened in 4% PFA over night, sectioned coronally on a vibratome (100 μm thickness) and viewed with a Biorad Radiance 2000 confocal system attached to a Nikon Eclipse 800 microscope.
T8079	36166-36171	IN	denotes	After
T8081	36172-36183	JJ	denotes	appropriate
T8083	36184-36193	NN	denotes	diffusion
T8082	36194-36198	NN	denotes	time
T8084	36199-36200	-LRB-	denotes	[
T8085	36200-36202	CD	denotes	43
T8086	36202-36203	-RRB-	denotes	]
T8087	36203-36205	,	denotes	,
T8088	36205-36208	DT	denotes	the
T8089	36209-36215	NNS	denotes	brains
T8090	36216-36220	IN	denotes	with
T8091	36221-36224	DT	denotes	the
T8093	36225-36233	VBN	denotes	attached
T8094	36234-36242	JJ	denotes	cochlear
T8092	36243-36248	NN	denotes	nerve
T8095	36249-36253	VBD	denotes	were
T8080	36254-36262	VBN	denotes	embedded
T8096	36263-36265	IN	denotes	in
T8097	36266-36273	NN	denotes	gelatin
T8098	36273-36275	,	denotes	,
T8099	36275-36283	VBN	denotes	hardened
T8100	36284-36286	IN	denotes	in
T8101	36287-36288	CD	denotes	4
T8102	36288-36289	NN	denotes	%
T8103	36290-36293	NN	denotes	PFA
T8104	36294-36298	IN	denotes	over
T8105	36299-36304	NN	denotes	night
T8106	36304-36306	,	denotes	,
T8107	36306-36315	VBN	denotes	sectioned
T8108	36316-36325	RB	denotes	coronally
T8109	36326-36328	IN	denotes	on
T8110	36329-36330	DT	denotes	a
T8111	36331-36340	NN	denotes	vibratome
T8112	36341-36342	-LRB-	denotes	(
T8114	36342-36345	CD	denotes	100
T8115	36346-36348	NN	denotes	μm
T8113	36349-36358	NN	denotes	thickness
T8116	36358-36359	-RRB-	denotes	)
T8117	36360-36363	CC	denotes	and
T8118	36364-36370	VBN	denotes	viewed
T8119	36371-36375	IN	denotes	with
T8120	36376-36377	DT	denotes	a
T8122	36378-36384	NNP	denotes	Biorad
T8123	36385-36393	NNP	denotes	Radiance
T8124	36394-36398	CD	denotes	2000
T8125	36399-36407	JJ	denotes	confocal
T8121	36408-36414	NN	denotes	system
T8126	36415-36423	VBN	denotes	attached
T8127	36424-36426	IN	denotes	to
T8128	36427-36428	DT	denotes	a
T8130	36429-36434	NNP	denotes	Nikon
T8131	36435-36442	NNP	denotes	Eclipse
T8132	36443-36446	CD	denotes	800
T8129	36447-36457	NN	denotes	microscope
T8133	36457-36458	.	denotes	.
T8134	36458-36551	sentence	denotes	Image stacks were collapsed to view the entire projection in one section in one focal plane.
T8135	36459-36464	NN	denotes	Image
T8136	36465-36471	NNS	denotes	stacks
T8138	36472-36476	VBD	denotes	were
T8137	36477-36486	VBN	denotes	collapsed
T8139	36487-36489	TO	denotes	to
T8140	36490-36494	VB	denotes	view
T8141	36495-36498	DT	denotes	the
T8143	36499-36505	JJ	denotes	entire
T8142	36506-36516	NN	denotes	projection
T8144	36517-36519	IN	denotes	in
T8145	36520-36523	CD	denotes	one
T8146	36524-36531	NN	denotes	section
T8147	36532-36534	IN	denotes	in
T8148	36535-36538	CD	denotes	one
T8150	36539-36544	JJ	denotes	focal
T8149	36545-36550	NN	denotes	plane
T8151	36550-36551	.	denotes	.
T8171	36553-36555	FW	denotes	In
T8172	36556-36560	FW	denotes	situ
T8173	36561-36574	NN	denotes	hybridization
T8174	36574-36788	sentence	denotes	Four ears each of Brn3c null mutants (P0 and P8) and control littermates were embedded in paraffin, sectioned and probed for the presence of BDNF and NT-3 mRNA using the in situ technique previously described [7].
T8175	36575-36579	CD	denotes	Four
T8176	36580-36584	NNS	denotes	ears
T8178	36585-36589	DT	denotes	each
T8179	36590-36592	IN	denotes	of
T8180	36593-36598	NN	denotes	Brn3c
T8181	36599-36603	JJ	denotes	null
T8182	36604-36611	NNS	denotes	mutants
T8183	36612-36613	-LRB-	denotes	(
T8184	36613-36615	NN	denotes	P0
T8185	36616-36619	CC	denotes	and
T8186	36620-36622	NN	denotes	P8
T8187	36622-36623	-RRB-	denotes	)
T8188	36624-36627	CC	denotes	and
T8189	36628-36635	NN	denotes	control
T8190	36636-36647	NNS	denotes	littermates
T8191	36648-36652	VBD	denotes	were
T8177	36653-36661	VBN	denotes	embedded
T8192	36662-36664	IN	denotes	in
T8193	36665-36673	NN	denotes	paraffin
T8194	36673-36675	,	denotes	,
T8195	36675-36684	VBN	denotes	sectioned
T8196	36685-36688	CC	denotes	and
T8197	36689-36695	VBN	denotes	probed
T8198	36696-36699	IN	denotes	for
T8199	36700-36703	DT	denotes	the
T8200	36704-36712	NN	denotes	presence
T8201	36713-36715	IN	denotes	of
T8202	36716-36720	NN	denotes	BDNF
T8204	36721-36724	CC	denotes	and
T8205	36725-36727	NN	denotes	NT
T8206	36727-36728	HYPH	denotes	-
T8207	36728-36729	CD	denotes	3
T8203	36730-36734	NN	denotes	mRNA
T8208	36735-36740	VBG	denotes	using
T8209	36741-36744	DT	denotes	the
T8211	36745-36747	FW	denotes	in
T8212	36748-36752	FW	denotes	situ
T8210	36753-36762	NN	denotes	technique
T8213	36763-36773	RB	denotes	previously
T8214	36774-36783	VBN	denotes	described
T8215	36784-36785	-LRB-	denotes	[
T8216	36785-36786	CD	denotes	7
T8217	36786-36787	-RRB-	denotes	]
T8218	36787-36788	.	denotes	.
T8219	36788-36875	sentence	denotes	Sections were lightly counterstained and viewed with bright and dark field microscopy.
T8220	36789-36797	NNS	denotes	Sections
T8222	36798-36802	VBD	denotes	were
T8223	36803-36810	RB	denotes	lightly
T8221	36811-36825	VBN	denotes	counterstained
T8224	36826-36829	CC	denotes	and
T8225	36830-36836	VBN	denotes	viewed
T8226	36837-36841	IN	denotes	with
T8227	36842-36848	JJ	denotes	bright
T8229	36849-36852	CC	denotes	and
T8230	36853-36857	JJ	denotes	dark
T8228	36858-36863	NN	denotes	field
T8231	36864-36874	NN	denotes	microscopy
T8232	36874-36875	.	denotes	.
T8233	36875-36980	sentence	denotes	Images were acquired with a CCD camera and displayed as false color images as previously described [18].
T8234	36876-36882	NNS	denotes	Images
T8236	36883-36887	VBD	denotes	were
T8235	36888-36896	VBN	denotes	acquired
T8237	36897-36901	IN	denotes	with
T8238	36902-36903	DT	denotes	a
T8240	36904-36907	NN	denotes	CCD
T8239	36908-36914	NN	denotes	camera
T8241	36915-36918	CC	denotes	and
T8242	36919-36928	VBD	denotes	displayed
T8243	36929-36931	IN	denotes	as
T8244	36932-36937	JJ	denotes	false
T8246	36938-36943	NN	denotes	color
T8245	36944-36950	NNS	denotes	images
T8247	36951-36953	IN	denotes	as
T8249	36954-36964	RB	denotes	previously
T8248	36965-36974	VBN	denotes	described
T8250	36975-36976	-LRB-	denotes	[
T8251	36976-36978	CD	denotes	18
T8252	36978-36979	-RRB-	denotes	]
T8253	36979-36980	.	denotes	.
T8327	36982-37001	NN	denotes	Immunocytochemistry
T8328	37002-37004	IN	denotes	of
T8329	37005-37009	NN	denotes	hair
T8330	37010-37015	NNS	denotes	cells
T8331	37016-37019	CC	denotes	and
T8332	37020-37034	NN	denotes	quantification
T8333	37035-37037	IN	denotes	of
T8334	37038-37042	NN	denotes	hair
T8335	37043-37048	NNS	denotes	cells
T8336	37049-37052	CC	denotes	and
T8337	37053-37060	NNS	denotes	neurons
T8338	37060-37205	sentence	denotes	Immunostaining of P7 cochlear whole mounts using the hair cell specific-myosin VII (MyoVIIa) antibody was performed as previously described [2].
T8339	37061-37075	NN	denotes	Immunostaining
T8341	37076-37078	IN	denotes	of
T8342	37079-37081	NN	denotes	P7
T8344	37082-37090	JJ	denotes	cochlear
T8345	37091-37096	JJ	denotes	whole
T8343	37097-37103	NNS	denotes	mounts
T8346	37104-37109	VBG	denotes	using
T8347	37110-37113	DT	denotes	the
T8349	37114-37118	NN	denotes	hair
T8350	37119-37123	NN	denotes	cell
T8351	37124-37132	JJ	denotes	specific
T8352	37132-37133	HYPH	denotes	-
T8353	37133-37139	NN	denotes	myosin
T8354	37140-37143	CD	denotes	VII
T8355	37144-37145	-LRB-	denotes	(
T8356	37145-37152	NN	denotes	MyoVIIa
T8357	37152-37153	-RRB-	denotes	)
T8348	37154-37162	NN	denotes	antibody
T8358	37163-37166	VBD	denotes	was
T8340	37167-37176	VBN	denotes	performed
T8359	37177-37179	IN	denotes	as
T8361	37180-37190	RB	denotes	previously
T8360	37191-37200	VBN	denotes	described
T8362	37201-37202	-LRB-	denotes	[
T8363	37202-37203	CD	denotes	2
T8364	37203-37204	-RRB-	denotes	]
T8365	37204-37205	.	denotes	.
T8366	37205-37378	sentence	denotes	Images of labeled organs of Corti were then acquired using a SPOT digital camera (Diagnostic Instruments Inc.) and the number of hair cells was scored from acquired images.
T8367	37206-37212	NNS	denotes	Images
T8369	37213-37215	IN	denotes	of
T8370	37216-37223	VBN	denotes	labeled
T8371	37224-37230	NNS	denotes	organs
T8372	37231-37233	IN	denotes	of
T8373	37234-37239	NNP	denotes	Corti
T8374	37240-37244	VBD	denotes	were
T8375	37245-37249	RB	denotes	then
T8368	37250-37258	VBN	denotes	acquired
T8376	37259-37264	VBG	denotes	using
T8377	37265-37266	DT	denotes	a
T8379	37267-37271	NN	denotes	SPOT
T8380	37272-37279	JJ	denotes	digital
T8378	37280-37286	NN	denotes	camera
T8381	37287-37288	-LRB-	denotes	(
T8383	37288-37298	NNP	denotes	Diagnostic
T8384	37299-37310	NNPS	denotes	Instruments
T8382	37311-37315	NNP	denotes	Inc.
T8385	37315-37316	-RRB-	denotes	)
T8386	37317-37320	CC	denotes	and
T8387	37321-37324	DT	denotes	the
T8388	37325-37331	NN	denotes	number
T8390	37332-37334	IN	denotes	of
T8391	37335-37339	NN	denotes	hair
T8392	37340-37345	NNS	denotes	cells
T8393	37346-37349	VBD	denotes	was
T8389	37350-37356	VBN	denotes	scored
T8394	37357-37361	IN	denotes	from
T8395	37362-37370	VBN	denotes	acquired
T8396	37371-37377	NNS	denotes	images
T8397	37377-37378	.	denotes	.
T8398	37378-37566	sentence	denotes	To determine the number of hair cells or neurons in vestibular endorgans or sensory ganglia, serial sections were stained with Cresyl Violet and images were similarly acquired and scored.
T8399	37379-37381	TO	denotes	To
T8400	37382-37391	VB	denotes	determine
T8402	37392-37395	DT	denotes	the
T8403	37396-37402	NN	denotes	number
T8404	37403-37405	IN	denotes	of
T8405	37406-37410	NN	denotes	hair
T8406	37411-37416	NNS	denotes	cells
T8407	37417-37419	CC	denotes	or
T8408	37420-37427	NNS	denotes	neurons
T8409	37428-37430	IN	denotes	in
T8410	37431-37441	JJ	denotes	vestibular
T8411	37442-37451	NNS	denotes	endorgans
T8412	37452-37454	CC	denotes	or
T8413	37455-37462	JJ	denotes	sensory
T8414	37463-37470	NNS	denotes	ganglia
T8415	37470-37472	,	denotes	,
T8416	37472-37478	JJ	denotes	serial
T8417	37479-37487	NNS	denotes	sections
T8418	37488-37492	VBD	denotes	were
T8401	37493-37500	VBN	denotes	stained
T8419	37501-37505	IN	denotes	with
T8420	37506-37512	NNP	denotes	Cresyl
T8421	37513-37519	NNP	denotes	Violet
T8422	37520-37523	CC	denotes	and
T8423	37524-37530	NNS	denotes	images
T8425	37531-37535	VBD	denotes	were
T8426	37536-37545	RB	denotes	similarly
T8424	37546-37554	VBN	denotes	acquired
T8427	37555-37558	CC	denotes	and
T8428	37559-37565	VBN	denotes	scored
T8429	37565-37566	.	denotes	.
T8430	37566-37679	sentence	denotes	Every other section was scored for each sensory epithelium and every forth section was scored for each ganglion.
T8431	37567-37572	DT	denotes	Every
T8433	37573-37578	JJ	denotes	other
T8432	37579-37586	NN	denotes	section
T8435	37587-37590	VBD	denotes	was
T8434	37591-37597	VBN	denotes	scored
T8436	37598-37601	IN	denotes	for
T8437	37602-37606	DT	denotes	each
T8439	37607-37614	JJ	denotes	sensory
T8438	37615-37625	NN	denotes	epithelium
T8440	37626-37629	CC	denotes	and
T8441	37630-37635	DT	denotes	every
T8443	37636-37641	JJ	denotes	forth
T8442	37642-37649	NN	denotes	section
T8445	37650-37653	VBD	denotes	was
T8444	37654-37660	VBN	denotes	scored
T8446	37661-37664	IN	denotes	for
T8447	37665-37669	DT	denotes	each
T8448	37670-37678	NN	denotes	ganglion
T8449	37678-37679	.	denotes	.
T8450	37679-37811	sentence	denotes	Only neurons or cells with a clear nucleus and nucleoli were counted and 4–6 samples were counted for each epithelium and ganglion.
T8451	37680-37684	RB	denotes	Only
T8452	37685-37692	NNS	denotes	neurons
T8454	37693-37695	CC	denotes	or
T8455	37696-37701	NNS	denotes	cells
T8456	37702-37706	IN	denotes	with
T8457	37707-37708	DT	denotes	a
T8459	37709-37714	JJ	denotes	clear
T8458	37715-37722	NN	denotes	nucleus
T8460	37723-37726	CC	denotes	and
T8461	37727-37735	NNS	denotes	nucleoli
T8462	37736-37740	VBD	denotes	were
T8453	37741-37748	VBN	denotes	counted
T8463	37749-37752	CC	denotes	and
T8464	37753-37754	CD	denotes	4
T8466	37754-37755	SYM	denotes	–
T8465	37755-37756	CD	denotes	6
T8467	37757-37764	NNS	denotes	samples
T8469	37765-37769	VBD	denotes	were
T8468	37770-37777	VBN	denotes	counted
T8470	37778-37781	IN	denotes	for
T8471	37782-37786	DT	denotes	each
T8472	37787-37797	NN	denotes	epithelium
T8473	37798-37801	CC	denotes	and
T8474	37802-37810	NN	denotes	ganglion
T8475	37810-37811	.	denotes	.
T8476	37811-37907	sentence	denotes	All data were tested for significance using two-sample Student's t-test with unequal variances.
T8477	37812-37815	DT	denotes	All
T8478	37816-37820	NNS	denotes	data
T8480	37821-37825	VBD	denotes	were
T8479	37826-37832	VBN	denotes	tested
T8481	37833-37836	IN	denotes	for
T8482	37837-37849	NN	denotes	significance
T8483	37850-37855	VBG	denotes	using
T8484	37856-37859	JJ	denotes	two
T8486	37859-37860	HYPH	denotes	-
T8487	37860-37866	JJ	denotes	sample
T8485	37867-37874	NN	denotes	Student
T8489	37874-37876	POS	denotes	's
T8490	37877-37878	NN	denotes	t
T8491	37878-37879	HYPH	denotes	-
T8488	37879-37883	NN	denotes	test
T8492	37884-37888	IN	denotes	with
T8493	37889-37896	JJ	denotes	unequal
T8494	37897-37906	NNS	denotes	variances
T8495	37906-37907	.	denotes	.
R10	T197	T196	punct	", ",retention
R100	T300	T298	prep	of,reduction
R1000	T1847	T1848	amod	null,"mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants"
R1001	T1849	T1848	prep	at,"mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants"
R1002	T1850	T1849	pobj	birth,at
R1003	T1851	T1850	punct	(,birth
R1004	T1852	T1850	appos	P0,birth
R1005	T1853	T1850	punct	),birth
R1006	T1855	T1856	amod	Vestibular,ganglia
R1007	T1856	T1857	nsubj	ganglia,are
R1008	T1858	T1857	acomp	smaller,are
R1009	T1859	T1858	prep	in,smaller
R101	T301	T300	pobj	afferents,of
R1010	T1860	T1861	nmod	Brn3c,mutants
R1011	T1861	T1859	pobj	mutants,in
R1012	T1862	T1861	amod	null,mutants
R1013	T1863	T1864	punct	(,1b
R1014	T1864	T1858	parataxis	1b,smaller
R1015	T1865	T1864	compound	Fig.,1b
R1016	T1866	T1864	punct	),1b
R1017	T1867	T1858	prep	than,smaller
R1018	T1868	T1867	prep	in,than
R1019	T1869	T1870	compound	control,littermates
R102	T302	T301	cc	or,afferents
R1020	T1870	T1868	pobj	littermates,in
R1021	T1871	T1872	punct	(,1a
R1022	T1872	T1868	parataxis	1a,in
R1023	T1873	T1872	compound	Fig.,1a
R1024	T1874	T1872	punct	),1a
R1025	T1875	T1858	punct	", ",smaller
R1026	T1876	T1858	cc	but,smaller
R1027	T1877	T1858	conj	larger,smaller
R1028	T1878	T1877	prep	than,larger
R1029	T1879	T1878	prep	in,than
R103	T303	T301	conj	efferents,afferents
R1030	T1880	T1881	npadvmod	BDNF,null
R1031	T1881	T1884	amod	null,mutants
R1032	T1882	T1880	cc	or,BDNF
R1033	T1883	T1880	conj	trkB,BDNF
R1034	T1884	T1879	pobj	mutants,in
R1035	T1885	T1884	prep	of,mutants
R1036	T1886	T1887	det	the,age
R1037	T1887	T1885	pobj	age,of
R1038	T1888	T1887	amod	same,age
R1039	T1889	T1890	punct	[,15
R104	T304	T305	dep	that,resembles
R1040	T1890	T1857	parataxis	15,are
R1041	T1891	T1890	nummod	13,15
R1042	T1892	T1890	punct	",",15
R1043	T1893	T1890	punct	],15
R1044	T1894	T1857	punct	.,are
R1045	T1896	T1897	det	The,reduction
R1046	T1897	T1898	nsubj	reduction,is
R1047	T1899	T1897	prep	in,reduction
R1048	T1900	T1901	amod	apparent,size
R1049	T1901	T1899	pobj	size,in
R105	T305	T301	relcl	resembles,afferents
R1050	T1902	T1897	prep	of,reduction
R1051	T1903	T1904	det	the,ganglia
R1052	T1904	T1902	pobj	ganglia,of
R1053	T1905	T1904	amod	vestibular,ganglia
R1054	T1906	T1898	prep	in,is
R1055	T1907	T1906	pobj	agreement,in
R1056	T1908	T1907	prep	with,agreement
R1057	T1909	T1910	amod	quantitative,data
R1058	T1910	T1908	pobj	data,with
R1059	T1911	T1910	acl	published,data
R106	T306	T307	nmod	neurotrophin,mutations
R1060	T1912	T1911	advmod	previously,published
R1061	T1913	T1914	punct	[,13
R1062	T1914	T1898	parataxis	13,is
R1063	T1915	T1914	nummod	3,13
R1064	T1916	T1914	punct	",",13
R1065	T1917	T1914	punct	],13
R1066	T1918	T1898	punct	.,is
R1067	T1920	T1921	det	These,data
R1068	T1921	T1922	nsubj	data,suggest
R1069	T1923	T1924	det	a,loss
R107	T307	T305	dobj	mutations,resembles
R1070	T1924	T1922	dobj	loss,suggest
R1071	T1925	T1924	prep	of,loss
R1072	T1926	T1927	quantmod	80,85
R1073	T1927	T1929	nummod	85,%
R1074	T1928	T1927	punct	–,85
R1075	T1929	T1925	pobj	%,of
R1076	T1930	T1929	prep	of,%
R1077	T1931	T1932	amod	vestibular,neurons
R1078	T1932	T1930	pobj	neurons,of
R1079	T1933	T1932	amod	sensory,neurons
R108	T308	T307	amod	null,mutations
R1080	T1934	T1929	prep	in,%
R1081	T1935	T1936	npadvmod	BDNF,null
R1082	T1936	T1939	amod	null,mutants
R1083	T1937	T1935	cc	and,BDNF
R1084	T1938	T1935	conj	trkB,BDNF
R1085	T1939	T1934	pobj	mutants,in
R1086	T1940	T1941	punct	[,13
R1087	T1941	T1939	parataxis	13,mutants
R1088	T1942	T1941	punct	],13
R1089	T1943	T1925	cc	and,of
R109	T309	T276	punct	.,is
R1090	T1944	T1925	conj	of,of
R1091	T1945	T1946	nummod	77,%
R1092	T1946	T1944	pobj	%,of
R1093	T1947	T1946	prep	of,%
R1094	T1948	T1949	amod	vestibular,neurons
R1095	T1949	T1947	pobj	neurons,of
R1096	T1950	T1949	amod	sensory,neurons
R1097	T1951	T1946	prep	in,%
R1098	T1952	T1953	compound	P4,Brn3c
R1099	T1953	T1954	npadvmod	Brn3c,null
R11	T198	T196	amod	incomplete,retention
R110	T311	T312	prep	At,reduced
R1100	T1954	T1955	amod	null,mutants
R1101	T1955	T1951	pobj	mutants,in
R1102	T1956	T1957	punct	[,3
R1103	T1957	T1955	parataxis	3,mutants
R1104	T1958	T1957	punct	],3
R1105	T1959	T1922	punct	.,suggest
R1106	T1961	T1962	advmod	Thus,be
R1107	T1963	T1962	punct	", ",be
R1108	T1964	T1965	det	the,reduction
R1109	T1965	T1962	nsubj	reduction,be
R111	T313	T314	amod	postnatal,day
R1110	T1966	T1965	compound	size,reduction
R1111	T1967	T1965	prep	in,reduction
R1112	T1968	T1969	det	the,ganglion
R1113	T1969	T1967	pobj	ganglion,in
R1114	T1970	T1969	amod	vestibular,ganglion
R1115	T1971	T1969	amod	sensory,ganglion
R1116	T1972	T1962	aux	could,be
R1117	T1973	T1962	acomp	compatible,be
R1118	T1974	T1973	prep	with,compatible
R1119	T1975	T1976	det	a,loss
R112	T314	T311	pobj	day,At
R1120	T1976	T1974	pobj	loss,with
R1121	T1977	T1976	prep	of,loss
R1122	T1978	T1979	compound	BDNF,production
R1123	T1979	T1977	pobj	production,of
R1124	T1980	T1976	prep	in,loss
R1125	T1981	T1982	det	the,cells
R1126	T1982	T1980	pobj	cells,in
R1127	T1983	T1982	amod	immature,cells
R1128	T1984	T1982	compound	hair,cells
R1129	T1985	T1962	punct	.,be
R113	T315	T314	nummod	7,day
R1130	T1991	T1992	advmod	wever,show
R1131	T1993	T1992	punct	", ",show
R1132	T1994	T1995	det	the,mutants
R1133	T1995	T1992	nsubj	mutants,show
R1134	T1996	T1995	nmod	Brn3c,mutants
R1135	T1997	T1995	amod	null,mutants
R1136	T1998	T1999	advmod	only,density
R1137	T1999	T1992	dobj	density,show
R1138	T2000	T1999	det	a,density
R1139	T2001	T1999	amod	reduced,density
R114	T316	T314	punct	/,day
R1140	T2002	T1999	prep	of,density
R1141	T2003	T2004	amod	afferent,fibers
R1142	T2004	T2002	pobj	fibers,of
R1143	T2005	T2003	cc	and,afferent
R1144	T2006	T2003	conj	efferent,afferent
R1145	T2007	T1992	prep	to,show
R1146	T2008	T2009	det	all,epithelia
R1147	T2009	T2007	pobj	epithelia,to
R1148	T2010	T2009	amod	vestibular,epithelia
R1149	T2011	T2009	amod	sensory,epithelia
R115	T317	T314	nummod	8,day
R1150	T2012	T1992	punct	.,show
R1151	T2014	T2015	expl	There,is
R1152	T2016	T2017	det	no,loss
R1153	T2017	T2015	attr	loss,is
R1154	T2018	T2017	amod	specific,loss
R1155	T2019	T2017	prep	of,loss
R1156	T2020	T2021	det	all,innervation
R1157	T2021	T2019	pobj	innervation,of
R1158	T2022	T2021	amod	afferent,innervation
R1159	T2023	T2022	cc	and,afferent
R116	T318	T314	punct	(,day
R1160	T2024	T2022	conj	efferent,afferent
R1161	T2025	T2017	prep	to,loss
R1162	T2026	T2027	det	the,crista
R1163	T2027	T2025	pobj	crista,to
R1164	T2028	T2027	amod	canal,crista
R1165	T2029	T2030	punct	(,2a
R1166	T2030	T2027	parataxis	2a,crista
R1167	T2031	T2030	compound	Fig.,2a
R1168	T2032	T2030	punct	),2a
R1169	T2033	T2017	punct	", ",loss
R117	T319	T314	appos	P7,day
R1170	T2034	T2035	det	a,hallmark
R1171	T2035	T2017	appos	hallmark,loss
R1172	T2036	T2035	prep	of,hallmark
R1173	T2037	T2038	preconj	both,BDNF
R1174	T2038	T2039	npadvmod	BDNF,null
R1175	T2039	T2042	amod	null,mutations
R1176	T2040	T2038	cc	and,BDNF
R1177	T2041	T2038	conj	trkB,BDNF
R1178	T2042	T2036	pobj	mutations,of
R1179	T2043	T2044	punct	[,15
R118	T320	T319	punct	/,P7
R1180	T2044	T2017	parataxis	15,loss
R1181	T2045	T2044	nummod	13,15
R1182	T2046	T2044	punct	",",15
R1183	T2047	T2044	punct	],15
R1184	T2048	T2015	punct	.,is
R1185	T2050	T2051	prep	In,seems
R1186	T2052	T2050	pobj	fact,In
R1187	T2053	T2051	punct	", ",seems
R1188	T2054	T2055	det	the,reduction
R1189	T2055	T2051	nsubj	reduction,seems
R119	T321	T319	nummod	8,P7
R1190	T2056	T2055	prep	of,reduction
R1191	T2057	T2056	pobj	fibers,of
R1192	T2058	T2059	aux	to,be
R1193	T2059	T2051	xcomp	be,seems
R1194	T2060	T2061	advmod	rather,uniform
R1195	T2061	T2059	acomp	uniform,be
R1196	T2062	T2059	prep	throughout,be
R1197	T2063	T2064	det	a,epithelium
R1198	T2064	T2062	pobj	epithelium,throughout
R1199	T2065	T2064	amod	given,epithelium
R12	T199	T196	prep	of,retention
R120	T322	T312	punct	),reduced
R1200	T2066	T2064	amod	sensory,epithelium
R1201	T2067	T2059	prep	with,be
R1202	T2068	T2069	det	the,innervation
R1203	T2069	T2071	nsubj	innervation,being
R1204	T2070	T2069	compound	crista,innervation
R1205	T2071	T2067	pcomp	being,with
R1206	T2072	T2071	advmod	qualitatively,being
R1207	T2073	T2074	neg	no,more
R1208	T2074	T2075	advmod	more,reduced
R1209	T2075	T2071	acomp	reduced,being
R121	T323	T312	punct	", ",reduced
R1210	T2076	T2075	prep	than,reduced
R1211	T2077	T2078	det	the,innervation
R1212	T2078	T2076	pobj	innervation,than
R1213	T2079	T2078	prep	of,innervation
R1214	T2080	T2081	det	the,utricle
R1215	T2081	T2079	pobj	utricle,of
R1216	T2082	T2081	cc	and,utricle
R1217	T2083	T2081	conj	saccule,utricle
R1218	T2084	T2051	punct	.,seems
R1219	T2086	T2087	det	No,loss
R122	T324	T312	nsubjpass	innervation,reduced
R1220	T2087	T2088	nsubj	loss,is
R1221	T2089	T2087	prep	in,loss
R1222	T2090	T2091	amod	specific,areas
R1223	T2091	T2089	pobj	areas,in
R1224	T2092	T2087	punct	", ",loss
R1225	T2093	T2087	amod	comparable,loss
R1226	T2094	T2093	prep	to,comparable
R1227	T2095	T2094	pobj	that,to
R1228	T2096	T2095	prep	in,that
R1229	T2097	T2098	npadvmod	BDNF,null
R123	T325	T312	auxpass	is,reduced
R1230	T2098	T2099	amod	null,mice
R1231	T2099	T2096	pobj	mice,in
R1232	T2100	T2099	amod	mutant,mice
R1233	T2101	T2088	punct	", ",is
R1234	T2102	T2088	acomp	apparent,is
R1235	T2103	T2088	prep	in,is
R1236	T2104	T2105	det	the,saccule
R1237	T2105	T2103	pobj	saccule,in
R1238	T2106	T2105	cc	or,saccule
R1239	T2107	T2105	conj	utricle,saccule
R124	T326	T312	advmod	severely,reduced
R1240	T2108	T2105	prep	of,saccule
R1241	T2109	T2110	npadvmod	Brn3c,null
R1242	T2110	T2111	amod	null,mice
R1243	T2111	T2108	pobj	mice,of
R1244	T2112	T2088	punct	.,is
R1245	T2114	T2115	amod	Similar,patterns
R1246	T2115	T2116	nsubjpass	patterns,obtained
R1247	T2117	T2115	prep	of,patterns
R1248	T2118	T2117	pobj	innervation,of
R1249	T2119	T2116	auxpass	are,obtained
R125	T327	T328	preconj	both,qualitatively
R1250	T2120	T2116	advcl	using,obtained
R1251	T2121	T2122	amod	acteylated,tubulin
R1252	T2122	T2123	compound	tubulin,immunocytochemistry
R1253	T2123	T2120	dobj	immunocytochemistry,using
R1254	T2124	T2125	punct	(,2b
R1255	T2125	T2116	parataxis	2b,obtained
R1256	T2126	T2125	compound	Fig.,2b
R1257	T2127	T2125	punct	),2b
R1258	T2128	T2116	punct	.,obtained
R1259	T2131	T2132	advcl	Consistent,show
R126	T328	T312	advmod	qualitatively,reduced
R1260	T2133	T2131	prep	with,Consistent
R1261	T2134	T2135	det	the,finding
R1262	T2135	T2133	pobj	finding,with
R1263	T2136	T2135	prep	of,finding
R1264	T2137	T2136	pobj	Xiang,of
R1265	T2138	T2139	advmod	et,al.
R1266	T2139	T2137	advmod	al.,Xiang
R1267	T2140	T2141	punct	[,3
R1268	T2141	T2137	parataxis	3,Xiang
R1269	T2142	T2141	punct	],3
R127	T329	T328	cc	and,qualitatively
R1270	T2143	T2135	prep	of,finding
R1271	T2144	T2145	advmod	only,loss
R1272	T2145	T2143	pobj	loss,of
R1273	T2146	T2145	det	a,loss
R1274	T2147	T2148	nummod	29,%
R1275	T2148	T2145	compound	%,loss
R1276	T2149	T2145	prep	of,loss
R1277	T2150	T2151	amod	spiral,neurons
R1278	T2151	T2149	pobj	neurons,of
R1279	T2152	T2151	amod	sensory,neurons
R128	T330	T328	conj	quantitatively,qualitatively
R1280	T2153	T2145	prep	at,loss
R1281	T2154	T2153	pobj	P4,at
R1282	T2155	T2132	punct	", ",show
R1283	T2156	T2157	poss	our,data
R1284	T2157	T2132	nsubj	data,show
R1285	T2158	T2159	amod	little,difference
R1286	T2159	T2132	dobj	difference,show
R1287	T2160	T2159	prep	in,difference
R1288	T2161	T2162	det	the,pattern
R1289	T2162	T2160	pobj	pattern,in
R129	T331	T312	punct	.,reduced
R1290	T2163	T2162	prep	of,pattern
R1291	T2164	T2163	pobj	innervation,of
R1292	T2165	T2164	prep	of,innervation
R1293	T2166	T2167	det	the,cochlea
R1294	T2167	T2165	pobj	cochlea,of
R1295	T2168	T2162	prep	in,pattern
R1296	T2169	T2170	nmod	P0,mutants
R1297	T2170	T2168	pobj	mutants,in
R1298	T2171	T2170	nmod	Brn3c,mutants
R1299	T2172	T2170	amod	null,mutants
R13	T200	T201	det	some,innervation
R130	T333	T334	nummod	1,%
R1300	T2173	T2174	punct	(,2d
R1301	T2174	T2132	parataxis	2d,show
R1302	T2175	T2174	nmod	Fig.,2d
R1303	T2176	T2174	nmod	2c,2d
R1304	T2177	T2174	punct	",",2d
R1305	T2178	T2174	punct	),2d
R1306	T2179	T2132	punct	.,show
R1307	T2181	T2182	det	No,loss
R1308	T2182	T2184	nsubjpass	loss,observed
R1309	T2183	T2182	amod	selective,loss
R131	T334	T335	nsubj	%,are
R1310	T2185	T2182	prep	of,loss
R1311	T2186	T2187	amod	spiral,neurons
R1312	T2187	T2185	pobj	neurons,of
R1313	T2188	T2184	auxpass	is,observed
R1314	T2189	T2184	prep	in,observed
R1315	T2190	T2191	nmod	Brn3c,mutants
R1316	T2191	T2189	pobj	mutants,in
R1317	T2192	T2191	amod	null,mutants
R1318	T2193	T2184	prep	in,observed
R1319	T2194	T2195	det	the,turn
R132	T336	T334	prep	of,%
R1320	T2195	T2193	pobj	turn,in
R1321	T2196	T2195	amod	basal,turn
R1322	T2197	T2184	punct	", ",observed
R1323	T2198	T2199	det	a,feature
R1324	T2199	T2184	npadvmod	feature,observed
R1325	T2200	T2199	prep	of,feature
R1326	T2201	T2202	preconj	either,NT
R1327	T2202	T2203	nmod	NT,loss
R1328	T2203	T2200	pobj	loss,of
R1329	T2204	T2202	punct	-,NT
R133	T337	T338	compound	myosin,VIIa
R1330	T2205	T2202	nummod	3,NT
R1331	T2206	T2202	cc	or,NT
R1332	T2207	T2202	conj	trkC,NT
R1333	T2208	T2209	punct	[,14
R1334	T2209	T2184	parataxis	14,observed
R1335	T2210	T2209	nummod	6,14
R1336	T2211	T2209	punct	",",14
R1337	T2212	T2209	nummod	9,14
R1338	T2213	T2209	punct	",",14
R1339	T2214	T2209	punct	],14
R134	T338	T339	npadvmod	VIIa,positive
R1340	T2215	T2184	punct	.,observed
R1341	T2217	T2218	advmod	Likewise,shows
R1342	T2219	T2218	punct	", ",shows
R1343	T2220	T2221	det	the,innervation
R1344	T2221	T2218	nsubj	innervation,shows
R1345	T2222	T2221	prep	of,innervation
R1346	T2223	T2224	det	the,apex
R1347	T2224	T2222	pobj	apex,of
R1348	T2225	T2226	punct	(,2f
R1349	T2226	T2221	parataxis	2f,innervation
R135	T339	T341	amod	positive,cells
R1350	T2227	T2226	compound	Fig.,2f
R1351	T2228	T2226	punct	),2f
R1352	T2229	T2230	det	no,abnormality
R1353	T2230	T2218	dobj	abnormality,shows
R1354	T2231	T2230	amod	detectable,abnormality
R1355	T2232	T2230	prep	in,abnormality
R1356	T2233	T2234	amod	overall,pattern
R1357	T2234	T2232	pobj	pattern,in
R1358	T2235	T2234	prep	of,pattern
R1359	T2236	T2235	pobj	innervation,of
R136	T340	T339	punct	-,positive
R1360	T2237	T2230	prep	compared,abnormality
R1361	T2238	T2237	prep	to,compared
R1362	T2239	T2240	compound	control,animals
R1363	T2240	T2238	pobj	animals,to
R1364	T2241	T2242	punct	(,shown
R1365	T2242	T2230	parataxis	shown,abnormality
R1366	T2243	T2242	nsubj	data,shown
R1367	T2244	T2242	neg	not,shown
R1368	T2245	T2242	punct	),shown
R1369	T2246	T2218	punct	", ",shows
R137	T341	T336	pobj	cells,of
R1370	T2247	T2248	det	an,indication
R1371	T2248	T2218	npadvmod	indication,shows
R1372	T2249	T2250	mark	that,expressed
R1373	T2250	T2248	acl	expressed,indication
R1374	T2251	T2250	nsubjpass	BDNF,expressed
R1375	T2252	T2250	aux	could,expressed
R1376	T2253	T2250	auxpass	be,expressed
R1377	T2254	T2250	prep	in,expressed
R1378	T2255	T2256	det	the,apex
R1379	T2256	T2254	pobj	apex,in
R138	T342	T341	amod	immature,cells
R1380	T2257	T2258	punct	[,6
R1381	T2258	T2218	parataxis	6,shows
R1382	T2259	T2258	punct	],6
R1383	T2260	T2218	punct	.,shows
R1384	T2262	T2263	prep	In,shows
R1385	T2264	T2262	pobj	addition,In
R1386	T2265	T2263	punct	", ",shows
R1387	T2266	T2267	det	the,pattern
R1388	T2267	T2263	nsubj	pattern,shows
R1389	T2268	T2267	prep	of,pattern
R139	T343	T341	compound	hair,cells
R1390	T2269	T2270	amod	efferent,innervation
R1391	T2270	T2268	pobj	innervation,of
R1392	T2271	T2272	det	no,deviation
R1393	T2272	T2263	dobj	deviation,shows
R1394	T2273	T2272	prep	from,deviation
R1395	T2274	T2273	pobj	normal,from
R1396	T2275	T2263	advmod	either,shows
R1397	T2276	T2277	punct	(,2e
R1398	T2277	T2263	parataxis	2e,shows
R1399	T2278	T2277	compound	Fig.,2e
R14	T201	T199	pobj	innervation,of
R140	T344	T335	acomp	present,are
R1400	T2279	T2277	punct	),2e
R1401	T2280	T2263	punct	", ",shows
R1402	T2281	T2282	mark	whereas,show
R1403	T2282	T2263	advcl	show,shows
R1404	T2283	T2282	nsubj	they,show
R1405	T2284	T2285	det	the,pattern
R1406	T2285	T2282	dobj	pattern,show
R1407	T2286	T2285	amod	same,pattern
R1408	T2287	T2285	prep	of,pattern
R1409	T2288	T2287	pobj	loss,of
R141	T345	T335	prep	in,are
R1410	T2289	T2285	prep	as,pattern
R1411	T2290	T2291	amod	afferent,fibers
R1412	T2291	T2289	pobj	fibers,as
R1413	T2292	T2291	prep	in,fibers
R1414	T2293	T2294	nmod	neurotrophin,mutants
R1415	T2294	T2292	pobj	mutants,in
R1416	T2295	T2294	amod	null,mutants
R1417	T2296	T2297	punct	[,16
R1418	T2297	T2282	parataxis	16,show
R1419	T2298	T2297	punct	],16
R142	T346	T347	det	the,cochlea
R1420	T2299	T2263	punct	.,shows
R1421	T2301	T2302	det	These,data
R1422	T2302	T2303	nsubj	data,suggest
R1423	T2304	T2305	mark	that,develop
R1424	T2305	T2303	ccomp	develop,suggest
R1425	T2306	T2307	det	the,neurons
R1426	T2307	T2305	nsubj	neurons,develop
R1427	T2308	T2307	amod	spiral,neurons
R1428	T2309	T2307	amod	sensory,neurons
R1429	T2310	T2311	advmod	qualitatively,normal
R143	T347	T345	pobj	cochlea,in
R1430	T2311	T2305	advcl	normal,develop
R1431	T2312	T2313	advmod	at,least
R1432	T2313	T2314	advmod	least,until
R1433	T2314	T2305	prep	until,develop
R1434	T2315	T2314	pobj	P0,until
R1435	T2316	T2305	cc	and,develop
R1436	T2317	T2318	advmod	therefore,allow
R1437	T2318	T2305	conj	allow,develop
R1438	T2319	T2320	amod	normal,pathfinding
R1439	T2320	T2318	dobj	pathfinding,allow
R144	T348	T347	amod	mutant,cochlea
R1440	T2321	T2320	prep	of,pathfinding
R1441	T2322	T2321	pobj	efferents,of
R1442	T2323	T2303	punct	.,suggest
R1443	T2325	T2326	advmod	Most,interestingly
R1444	T2326	T2327	advmod	interestingly,is
R1445	T2328	T2327	punct	", ",is
R1446	T2329	T2327	expl	there,is
R1447	T2330	T2331	det	no,increase
R1448	T2331	T2327	attr	increase,is
R1449	T2332	T2331	prep	in,increase
R145	T349	T335	punct	", ",are
R1450	T2333	T2334	amod	radial,fiber
R1451	T2334	T2335	compound	fiber,spacing
R1452	T2335	T2332	pobj	spacing,in
R1453	T2336	T2335	prep	in,spacing
R1454	T2337	T2338	det	the,apex
R1455	T2338	T2336	pobj	apex,in
R1456	T2339	T2327	punct	", ",is
R1457	T2340	T2341	det	a,problem
R1458	T2341	T2327	npadvmod	problem,is
R1459	T2342	T2341	amod	specific,problem
R146	T350	T335	advcl	concentrated,are
R1460	T2343	T2341	prep	of,problem
R1461	T2344	T2345	nmod	BDNF,mutants
R1462	T2345	T2343	pobj	mutants,of
R1463	T2346	T2345	amod	null,mutants
R1464	T2347	T2348	punct	[,13
R1465	T2348	T2327	parataxis	13,is
R1466	T2349	T2348	nummod	6,13
R1467	T2350	T2348	punct	",",13
R1468	T2351	T2348	punct	],13
R1469	T2352	T2327	punct	.,is
R147	T351	T350	prep	in,concentrated
R1470	T2354	T2355	advmod	However,is
R1471	T2356	T2355	punct	", ",is
R1472	T2357	T2355	expl	there,is
R1473	T2358	T2359	nummod	one,difference
R1474	T2359	T2355	attr	difference,is
R1475	T2360	T2359	amod	qualitative,difference
R1476	T2361	T2362	neg	not,recognized
R1477	T2362	T2359	acl	recognized,difference
R1478	T2363	T2362	prep	in,recognized
R1479	T2364	T2365	det	any,mutant
R148	T352	T353	det	the,base
R1480	T2365	T2363	pobj	mutant,in
R1481	T2366	T2367	amod	single,neurotrophin
R1482	T2367	T2368	npadvmod	neurotrophin,null
R1483	T2368	T2365	amod	null,mutant
R1484	T2369	T2355	punct	.,is
R1485	T2371	T2372	nsubj	Afferents,reach
R1486	T2373	T2374	det	all,rows
R1487	T2374	T2372	dobj	rows,reach
R1488	T2375	T2374	nummod	three,rows
R1489	T2376	T2374	prep	of,rows
R149	T353	T351	pobj	base,in
R1490	T2377	T2378	amod	outer,cells
R1491	T2378	T2376	pobj	cells,of
R1492	T2379	T2378	compound	hair,cells
R1493	T2380	T2372	prep	in,reach
R1494	T2381	T2382	det	the,turn
R1495	T2382	T2380	pobj	turn,in
R1496	T2383	T2382	amod	basal,turn
R1497	T2384	T2382	prep	of,turn
R1498	T2385	T2386	nmod	control,littermates
R1499	T2386	T2384	pobj	littermates,of
R15	T202	T201	amod	afferent,innervation
R150	T354	T335	punct	.,are
R1500	T2387	T2386	amod	wildtype,littermates
R1501	T2388	T2389	punct	(,2c
R1502	T2389	T2372	parataxis	2c,reach
R1503	T2390	T2389	compound	Fig.,2c
R1504	T2391	T2389	punct	),2c
R1505	T2392	T2372	punct	", ",reach
R1506	T2393	T2372	cc	but,reach
R1507	T2394	T2395	preconj	both,afferent
R1508	T2395	T2396	amod	afferent,outgrowth
R1509	T2396	T2399	nsubj	outgrowth,is
R151	T356	T357	quantmod	Around,20
R1510	T2397	T2395	cc	and,afferent
R1511	T2398	T2395	conj	efferent,afferent
R1512	T2399	T2372	conj	is,reach
R1513	T2400	T2399	acomp	disorganized,is
R1514	T2401	T2400	prep	to,disorganized
R1515	T2402	T2403	amod	outer,cells
R1516	T2403	T2401	pobj	cells,to
R1517	T2404	T2403	compound	hair,cells
R1518	T2405	T2399	prep	in,is
R1519	T2406	T2407	npadvmod	Brn3c,null
R152	T357	T358	nummod	20,%
R1520	T2407	T2408	amod	null,mutants
R1521	T2408	T2405	pobj	mutants,in
R1522	T2409	T2410	punct	(,2d
R1523	T2410	T2399	parataxis	2d,is
R1524	T2411	T2410	compound	Fig.,2d
R1525	T2412	T2410	punct	),2d
R1526	T2413	T2399	cc	and,is
R1527	T2414	T2415	aux	does,show
R1528	T2415	T2399	conj	show,is
R1529	T2416	T2415	neg	not,show
R153	T358	T359	nsubj	%,exist
R1530	T2417	T2418	det	any,organization
R1531	T2418	T2415	dobj	organization,show
R1532	T2419	T2418	amod	clear,organization
R1533	T2420	T2418	prep	into,organization
R1534	T2421	T2422	nummod	three,bundles
R1535	T2422	T2420	pobj	bundles,into
R1536	T2423	T2422	amod	distinct,bundles
R1537	T2424	T2422	amod	longitudinal,bundles
R1538	T2425	T2422	compound	fiber,bundles
R1539	T2426	T2422	acl	paralleling,bundles
R154	T360	T358	prep	of,%
R1540	T2427	T2428	det	the,rows
R1541	T2428	T2426	dobj	rows,paralleling
R1542	T2429	T2428	nummod	three,rows
R1543	T2430	T2428	prep	in,rows
R1544	T2431	T2432	det	the,region
R1545	T2432	T2430	pobj	region,in
R1546	T2433	T2432	amod	outer,region
R1547	T2434	T2435	compound	hair,cell
R1548	T2435	T2432	compound	cell,region
R1549	T2436	T2399	punct	.,is
R155	T361	T362	amod	immature,cells
R1550	T2438	T2439	det	These,data
R1551	T2439	T2440	nsubj	data,suggest
R1552	T2441	T2442	mark	that,disrupted
R1553	T2442	T2440	ccomp	disrupted,suggest
R1554	T2443	T2444	compound	fiber,organization
R1555	T2444	T2442	nsubjpass	organization,disrupted
R1556	T2445	T2444	prep	in,organization
R1557	T2446	T2447	det	the,region
R1558	T2447	T2445	pobj	region,in
R1559	T2448	T2447	amod	outer,region
R156	T362	T360	pobj	cells,of
R1560	T2449	T2450	compound	hair,cell
R1561	T2450	T2447	compound	cell,region
R1562	T2451	T2442	auxpass	is,disrupted
R1563	T2452	T2442	advmod	partly,disrupted
R1564	T2453	T2442	prep	in,disrupted
R1565	T2454	T2455	npadvmod	Brn3c,null
R1566	T2455	T2456	amod	null,mutant
R1567	T2456	T2453	pobj	mutant,in
R1568	T2457	T2440	punct	.,suggest
R157	T363	T362	compound	hair,cells
R1579	T2767	T2768	nmod	Brn3c,"mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants at birth (P0) Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13,15]. The reduction in apparent size of the vestibular ganglia is in agreement with quantitative data published previously [3,13]. These data suggest a loss of 80–85% of vestibular sensory neurons in BDNF and trkB null mutants [13] and of 77% of vestibular sensory neurons in P4 Brn3c null mutants [3]. Thus, the size reduction in the vestibular sensory ganglion could be compatible with a loss of BDNF production in the immature hair cells. Figure 1 Size variations of vestibular ganglia in control and mutant littermates labeled with DiI. In newborn animals, the vestibular ganglion shows a dramatic reduction in Brn3c null mutants (b) compared to control littermates (a). Abbreviations for this and other figures: AC, anterior crista; ggl, ganglion; c, spiral capillary; Genic. ggl., geniculate ganglion; GER, greater epithelial ridge; HC, horizontal crista; HaC, vestibular hair cell; IHC, inner hair cell; iHC, immature hair cell; IGSB, intraganglionic spiral bundle; OHC, outer hair cell; PC, posterior crista; S, saccule; SG, spiral ganglion; TM, tectorial membrane; U, utricle; VCN, ventral cochlear nucleus; VG, vestibular ganglion. Bar indicates 1000 μm. However, the Brn3c null mutants show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia. There is no specific loss of all afferent and efferent innervation to the canal crista (Fig. 2a), a hallmark of both BDNF and trkB null mutations [13,15]. In fact, the reduction of fibers seems to be rather uniform throughout a given sensory epithelium with the crista innervation being qualitatively no more reduced than the innervation of the utricle and saccule. No loss in specific areas, comparable to that in BDNF null mutant mice, is apparent in the saccule or utricle of Brn3c null mice. Similar patterns of innervation are obtained using acteylated tubulin immunocytochemistry (Fig. 2b). Figure 2 Innervation of Brn3c null and control ears are shown for newborn mice. There is no specific loss of fibers to any vestibular endorgan, as visualized by DiI labeling (a) or acetylated tubulin immunoreactivity (b). No major differences in pattern of projection through radial fibers are found in the cochlea of Brn3c null mutants (d,f) as compared to control littermates (c). Note, however, the lack of orderly fiber outgrowth to the outer hair cells (c, d). Efferent fibers to the ear show a well developed intraganglionic spiral bundle (IGSB) with no detectable differences compared to controls (e). Bar indicates 100 μm. Consistent with the finding of Xiang et al. [3] of only a 29% loss of spiral sensory neurons at P4, our data show little difference in the pattern of innervation of the cochlea in P0 Brn3c null mutants (Fig. 2c,2d). No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [6,9,14]. Likewise, the innervation of the apex (Fig. 2f) shows no detectable abnormality in overall pattern of innervation compared to control animals (data not shown), an indication that BDNF could be expressed in the apex [6]. In addition, the pattern of efferent innervation shows no deviation from normal either (Fig. 2e), whereas they show the same pattern of loss as afferent fibers in neurotrophin null mutants [16]. These data suggest that the spiral sensory neurons develop qualitatively normal at least until P0 and therefore allow normal pathfinding of efferents. Most interestingly, there is no increase in radial fiber spacing in the apex, a specific problem of BDNF null mutants [6,13]. However, there is one qualitative difference not recognized in any single neurotrophin null mutant. Afferents reach all three rows of outer hair cells in the basal turn of control wildtype littermates (Fig. 2c), but both afferent and efferent outgrowth is disorganized to outer hair cells in Brn3c null mutants (Fig. 2d) and does not show any clear organization into three distinct longitudinal fiber bundles paralleling the three rows in the outer hair cell region. These data suggest that fiber organization in the outer hair cell region is partly disrupted in Brn3c null mutant. Brn3c null mutants"
R158	T364	T359	prep	in,exist
R1580	T2769	T2768	amod	null,"mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants at birth (P0) Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13,15]. The reduction in apparent size of the vestibular ganglia is in agreement with quantitative data published previously [3,13]. These data suggest a loss of 80–85% of vestibular sensory neurons in BDNF and trkB null mutants [13] and of 77% of vestibular sensory neurons in P4 Brn3c null mutants [3]. Thus, the size reduction in the vestibular sensory ganglion could be compatible with a loss of BDNF production in the immature hair cells. Figure 1 Size variations of vestibular ganglia in control and mutant littermates labeled with DiI. In newborn animals, the vestibular ganglion shows a dramatic reduction in Brn3c null mutants (b) compared to control littermates (a). Abbreviations for this and other figures: AC, anterior crista; ggl, ganglion; c, spiral capillary; Genic. ggl., geniculate ganglion; GER, greater epithelial ridge; HC, horizontal crista; HaC, vestibular hair cell; IHC, inner hair cell; iHC, immature hair cell; IGSB, intraganglionic spiral bundle; OHC, outer hair cell; PC, posterior crista; S, saccule; SG, spiral ganglion; TM, tectorial membrane; U, utricle; VCN, ventral cochlear nucleus; VG, vestibular ganglion. Bar indicates 1000 μm. However, the Brn3c null mutants show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia. There is no specific loss of all afferent and efferent innervation to the canal crista (Fig. 2a), a hallmark of both BDNF and trkB null mutations [13,15]. In fact, the reduction of fibers seems to be rather uniform throughout a given sensory epithelium with the crista innervation being qualitatively no more reduced than the innervation of the utricle and saccule. No loss in specific areas, comparable to that in BDNF null mutant mice, is apparent in the saccule or utricle of Brn3c null mice. Similar patterns of innervation are obtained using acteylated tubulin immunocytochemistry (Fig. 2b). Figure 2 Innervation of Brn3c null and control ears are shown for newborn mice. There is no specific loss of fibers to any vestibular endorgan, as visualized by DiI labeling (a) or acetylated tubulin immunoreactivity (b). No major differences in pattern of projection through radial fibers are found in the cochlea of Brn3c null mutants (d,f) as compared to control littermates (c). Note, however, the lack of orderly fiber outgrowth to the outer hair cells (c, d). Efferent fibers to the ear show a well developed intraganglionic spiral bundle (IGSB) with no detectable differences compared to controls (e). Bar indicates 100 μm. Consistent with the finding of Xiang et al. [3] of only a 29% loss of spiral sensory neurons at P4, our data show little difference in the pattern of innervation of the cochlea in P0 Brn3c null mutants (Fig. 2c,2d). No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [6,9,14]. Likewise, the innervation of the apex (Fig. 2f) shows no detectable abnormality in overall pattern of innervation compared to control animals (data not shown), an indication that BDNF could be expressed in the apex [6]. In addition, the pattern of efferent innervation shows no deviation from normal either (Fig. 2e), whereas they show the same pattern of loss as afferent fibers in neurotrophin null mutants [16]. These data suggest that the spiral sensory neurons develop qualitatively normal at least until P0 and therefore allow normal pathfinding of efferents. Most interestingly, there is no increase in radial fiber spacing in the apex, a specific problem of BDNF null mutants [6,13]. However, there is one qualitative difference not recognized in any single neurotrophin null mutant. Afferents reach all three rows of outer hair cells in the basal turn of control wildtype littermates (Fig. 2c), but both afferent and efferent outgrowth is disorganized to outer hair cells in Brn3c null mutants (Fig. 2d) and does not show any clear organization into three distinct longitudinal fiber bundles paralleling the three rows in the outer hair cell region. These data suggest that fiber organization in the outer hair cell region is partly disrupted in Brn3c null mutant. Brn3c null mutants"
R1581	T2770	T2768	prep	at,"mutant mice show long-term, incomplete retention of some afferent inner ear innervation Abstract Background Ears of Brn3c null mutants develop immature hair cells, identifiable only by certain molecular markers, and undergo apoptosis in neonates. This partial development of hair cells could lead to enough neurotrophin expression to sustain sensory neurons through embryonic development. We have therefore investigated in these mutants the patterns of innervation and of expression of known neurotrophins. Results At birth there is a limited expression of BDNF and NT-3 in the mutant sensory epithelia and DiI tracing shows no specific reduction of afferents or efferents that resembles neurotrophin null mutations. At postnatal day 7/8 (P7/8), innervation is severely reduced both qualitatively and quantitatively. 1% of myosin VIIa-positive immature hair cells are present in the mutant cochlea, concentrated in the base. Around 20% of immature hair cells exist in the mutant vestibular sensory epithelia. Despite more severe loss of hair cells (1% compared to 20%), the cochlea retains many more sensory neurons (46% compared to 15%) than vestibular epithelia. Even 6 months old mutant mice have some fibers to all vestibular sensory epithelia and many more to the cochlear apex which lacks MyoVIIa positive hair cells. Topologically organized central cochlea projections exist at least until P8, suggesting that functional hair cells are not required to establish such projections. Conclusion The limited expression of neurotrophins in the cochlea of Brn3c null mice suffices to support many sensory neurons, particularly in the cochlea, until birth. The molecular nature of the long term survival of apical spiral neurons remains unclear. Background Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1,2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and parvalbumin [3]. Furthermore, these immature hair cells of Brn3c null mutants undergo apoptosis in neonates [3]. Consistent with an apparent absence of mature hair cells, initial work suggested that all vestibular and most spiral ganglion cells are lost by postnatal day 14 (P14; [1]). However, more detailed quantification by others [3] reported that at P4 about 77% of vestibular neurons and only 29% of spiral neurons are lost. It was suggested that there is possibly a complete loss in adults [3]. Other than these preliminary statements, no data exists concerning the detailed pattern of loss of innervation in Brn3c null mutants. The initial development and partial differentiation of hair cells in Brn3c mutants could possibly lead to some neurotrophin expression in these cells to sustain sensory neurons through embryonic development and beyond. Data on various single and compound neurotrophin null mutants have shown that the loss of a specific neurotrophin leads to topologically restricted loss of sensory neurons in the embryonic ear [4,5]. Such selective loss in Brn3c null mutants would therefore indicate reduction of a specific neurotrophin in immature hair cells. Moreover, recent work shows that in embryos NT-3 is primarily expressed in supporting cells, moving only around birth into hair cells [6,7]. In fact, the selective loss of vestibular as compared to cochlear sensory neurons (77% versus 29%; [3]) suggests that NT-3 expression may be less downregulated in Brn3c null mutants than BDNF [6,8,9], provided that at least some differentiation of supporting cells takes place. In the ear [4] as well as elsewhere [10] neurotrophins are progressively downregulated in postnatal mammals and possibly replaced by other factors [11]. We have investigated in detail the pattern of innervation in the Brn3c mutants, as well as the expression of NT-3 and BDNF. We want to evaluate a possible correlation between the topology of sensory neuron loss and absence of a specific neurotrophin or topological loss of hair cells at birth and in older animals. This information could be important for an in-depth evaluation of the human deafness related to the Pou4f3 gene, DFNA15 [12]. We report here long term retention of cochlear sensory neurons for at least 6 months, in particular in the cochlear apex, in Brn3c null mutant mice. This retention of afferents and efferents is unrelated to hair cell differentiation as not even immature hair cells can be detected at early postnatal stages with MyoVII immunocytochemistry in this part of the cochlea. This retention of apical spiral neurons is also largely unrelated to neurotrophins which are known to be reduced in their expression in neonatal rodents [4]. Results To appreciate the effects of the Brn3c null mutation on the pattern of the inner ear innervation, we first want to present the effects of BDNF and NT-3 null mutations at birth [6,13,14]. Null mutants of BDNF or its receptor trkB lose all innervation to the semicircular canals and have a reduced innervation to the utricle, saccule and apical turn of the cochlea. In contrast, null mutations of either NT-3 or its receptor trkC result in loss of spiral neurons in the basal turn with formation of an inner spiral bundle of afferents extending to the basal tip. Our null hypothesis for this study would be that Brn3c null mice show severe compromised production of these neurotrophins and should therefore show a comparable pattern of nerve fiber loss. Brn3c null mutants at birth (P0) Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13,15]. The reduction in apparent size of the vestibular ganglia is in agreement with quantitative data published previously [3,13]. These data suggest a loss of 80–85% of vestibular sensory neurons in BDNF and trkB null mutants [13] and of 77% of vestibular sensory neurons in P4 Brn3c null mutants [3]. Thus, the size reduction in the vestibular sensory ganglion could be compatible with a loss of BDNF production in the immature hair cells. Figure 1 Size variations of vestibular ganglia in control and mutant littermates labeled with DiI. In newborn animals, the vestibular ganglion shows a dramatic reduction in Brn3c null mutants (b) compared to control littermates (a). Abbreviations for this and other figures: AC, anterior crista; ggl, ganglion; c, spiral capillary; Genic. ggl., geniculate ganglion; GER, greater epithelial ridge; HC, horizontal crista; HaC, vestibular hair cell; IHC, inner hair cell; iHC, immature hair cell; IGSB, intraganglionic spiral bundle; OHC, outer hair cell; PC, posterior crista; S, saccule; SG, spiral ganglion; TM, tectorial membrane; U, utricle; VCN, ventral cochlear nucleus; VG, vestibular ganglion. Bar indicates 1000 μm. However, the Brn3c null mutants show only a reduced density of afferent and efferent fibers to all vestibular sensory epithelia. There is no specific loss of all afferent and efferent innervation to the canal crista (Fig. 2a), a hallmark of both BDNF and trkB null mutations [13,15]. In fact, the reduction of fibers seems to be rather uniform throughout a given sensory epithelium with the crista innervation being qualitatively no more reduced than the innervation of the utricle and saccule. No loss in specific areas, comparable to that in BDNF null mutant mice, is apparent in the saccule or utricle of Brn3c null mice. Similar patterns of innervation are obtained using acteylated tubulin immunocytochemistry (Fig. 2b). Figure 2 Innervation of Brn3c null and control ears are shown for newborn mice. There is no specific loss of fibers to any vestibular endorgan, as visualized by DiI labeling (a) or acetylated tubulin immunoreactivity (b). No major differences in pattern of projection through radial fibers are found in the cochlea of Brn3c null mutants (d,f) as compared to control littermates (c). Note, however, the lack of orderly fiber outgrowth to the outer hair cells (c, d). Efferent fibers to the ear show a well developed intraganglionic spiral bundle (IGSB) with no detectable differences compared to controls (e). Bar indicates 100 μm. Consistent with the finding of Xiang et al. [3] of only a 29% loss of spiral sensory neurons at P4, our data show little difference in the pattern of innervation of the cochlea in P0 Brn3c null mutants (Fig. 2c,2d). No selective loss of spiral neurons is observed in Brn3c null mutants in the basal turn, a feature of either NT-3 or trkC loss [6,9,14]. Likewise, the innervation of the apex (Fig. 2f) shows no detectable abnormality in overall pattern of innervation compared to control animals (data not shown), an indication that BDNF could be expressed in the apex [6]. In addition, the pattern of efferent innervation shows no deviation from normal either (Fig. 2e), whereas they show the same pattern of loss as afferent fibers in neurotrophin null mutants [16]. These data suggest that the spiral sensory neurons develop qualitatively normal at least until P0 and therefore allow normal pathfinding of efferents. Most interestingly, there is no increase in radial fiber spacing in the apex, a specific problem of BDNF null mutants [6,13]. However, there is one qualitative difference not recognized in any single neurotrophin null mutant. Afferents reach all three rows of outer hair cells in the basal turn of control wildtype littermates (Fig. 2c), but both afferent and efferent outgrowth is disorganized to outer hair cells in Brn3c null mutants (Fig. 2d) and does not show any clear organization into three distinct longitudinal fiber bundles paralleling the three rows in the outer hair cell region. These data suggest that fiber organization in the outer hair cell region is partly disrupted in Brn3c null mutant. Brn3c null mutants"
R1582	T2771	T2770	pobj	P7,at
R1583	T2772	T2771	punct	/,P7
R1584	T2773	T2771	nummod	8,P7
R1585	T2775	T2776	nsubj	Reduction,is
R1586	T2777	T2775	prep	of,Reduction
R1587	T2778	T2779	amod	vestibular,innervation
R1588	T2779	T2777	pobj	innervation,of
R1589	T2780	T2781	advmod	more,pronounced
R159	T365	T366	det	the,epithelia
R1590	T2781	T2776	acomp	pronounced,is
R1591	T2782	T2781	prep	than,pronounced
R1592	T2783	T2782	prep	at,than
R1593	T2784	T2783	pobj	P0,at
R1594	T2785	T2776	punct	.,is
R1595	T2787	T2788	nsubj	Loss,is
R1596	T2789	T2787	prep	of,Loss
R1597	T2790	T2789	pobj	afferents,of
R1598	T2791	T2789	cc	and,of
R1599	T2792	T2789	punct	", ",of
R16	T203	T204	amod	inner,ear
R160	T366	T364	pobj	epithelia,in
R1600	T2793	T2794	advmod	even,more
R1601	T2794	T2795	advmod	more,clearly
R1602	T2795	T2796	advmod	clearly,of
R1603	T2796	T2789	conj	of,of
R1604	T2797	T2796	pobj	efferents,of
R1605	T2798	T2788	punct	", ",is
R1606	T2799	T2800	advmod	most,pronounced
R1607	T2800	T2788	acomp	pronounced,is
R1608	T2801	T2788	prep	in,is
R1609	T2802	T2803	det	the,utricle
R161	T367	T366	amod	mutant,epithelia
R1610	T2803	T2801	pobj	utricle,in
R1611	T2804	T2805	punct	(,3b
R1612	T2805	T2803	parataxis	3b,utricle
R1613	T2806	T2805	nmod	Fig.,3b
R1614	T2807	T2805	nmod	3a,3b
R1615	T2808	T2805	punct	",",3b
R1616	T2809	T2805	punct	),3b
R1617	T2810	T2803	cc	and,utricle
R1618	T2811	T2803	conj	saccule,utricle
R1619	T2812	T2813	punct	(,shown
R162	T368	T366	amod	vestibular,epithelia
R1620	T2813	T2811	parataxis	shown,saccule
R1621	T2814	T2813	nsubj	data,shown
R1622	T2815	T2813	neg	not,shown
R1623	T2816	T2813	punct	),shown
R1624	T2817	T2788	punct	.,is
R1625	T2819	T2820	prep	In,changed
R1626	T2821	T2819	pobj	contrast,In
R1627	T2822	T2820	punct	", ",changed
R1628	T2823	T2824	det	the,innervation
R1629	T2824	T2820	nsubj	innervation,changed
R163	T369	T366	amod	sensory,epithelia
R1630	T2825	T2824	prep	to,innervation
R1631	T2826	T2827	det	the,cristae
R1632	T2827	T2825	pobj	cristae,to
R1633	T2828	T2827	amod	canal,cristae
R1634	T2829	T2820	punct	", ",changed
R1635	T2830	T2831	mark	while,reduced
R1636	T2831	T2820	advcl	reduced,changed
R1637	T2832	T2820	punct	", ",changed
R1638	T2833	T2820	aux	has,changed
R1639	T2834	T2820	npadvmod	little,changed
R164	T370	T359	punct	.,exist
R1640	T2835	T2820	prep	from,changed
R1641	T2836	T2835	pobj	P0,from
R1642	T2837	T2820	punct	.,changed
R1643	T2839	T2840	prep	In,receives
R1644	T2841	T2839	amod	particular,In
R1645	T2842	T2843	det	the,canal
R1646	T2843	T2840	nsubj	canal,receives
R1647	T2844	T2843	amod	horizontal,canal
R1648	T2845	T2846	det	a,innervation
R1649	T2846	T2840	dobj	innervation,receives
R165	T372	T373	prep	Despite,retains
R1650	T2847	T2848	advmod	rather,dense
R1651	T2848	T2846	amod	dense,innervation
R1652	T2849	T2846	amod	afferent,innervation
R1653	T2850	T2849	cc	and,afferent
R1654	T2851	T2849	conj	efferent,afferent
R1655	T2852	T2840	prep	in,receives
R1656	T2853	T2854	nmod	Brn3c,mutants
R1657	T2854	T2852	pobj	mutants,in
R1658	T2855	T2854	amod	null,mutants
R1659	T2856	T2840	punct	.,receives
R166	T374	T375	advmod	more,severe
R1660	T2862	T2861	pobj	c,o
R1661	T2865	T2866	det	e,a
R1662	T2866	T2862	conj	a,c
R1663	T2872	T2873	advmod	more,deviations
R1664	T2873	T2870	dobj	deviations,shows
R1665	T2874	T2873	amod	qualitative,deviations
R1666	T2875	T2873	prep	from,deviations
R1667	T2876	T2877	det	the,pattern
R1668	T2877	T2875	pobj	pattern,from
R1669	T2878	T2877	amod	normal,pattern
R167	T375	T376	amod	severe,loss
R1670	T2879	T2877	prep	of,pattern
R1671	T2880	T2879	pobj	innervation,of
R1672	T2881	T2870	punct	.,shows
R1673	T2883	T2884	prep	For,receive
R1674	T2885	T2883	pobj	example,For
R1675	T2886	T2884	punct	", ",receive
R1676	T2887	T2888	det	all,rows
R1677	T2888	T2884	nsubj	rows,receive
R1678	T2889	T2888	nummod	three,rows
R1679	T2890	T2888	prep	of,rows
R168	T376	T372	pobj	loss,Despite
R1680	T2891	T2892	amod	outer,cells
R1681	T2892	T2890	pobj	cells,of
R1682	T2893	T2892	compound	hair,cells
R1683	T2894	T2884	advmod	now,receive
R1684	T2895	T2896	preconj	both,afferent
R1685	T2896	T2897	amod	afferent,innervation
R1686	T2897	T2884	dobj	innervation,receive
R1687	T2898	T2896	cc	and,afferent
R1688	T2899	T2896	conj	efferent,afferent
R1689	T2900	T2884	prep	in,receive
R169	T377	T376	prep	of,loss
R1690	T2901	T2902	det	the,base
R1691	T2902	T2900	pobj	base,in
R1692	T2903	T2902	prep	of,base
R1693	T2904	T2905	compound	control,littermates
R1694	T2905	T2903	pobj	littermates,of
R1695	T2906	T2907	punct	(,3c
R1696	T2907	T2884	parataxis	3c,receive
R1697	T2908	T2907	compound	Fig.,3c
R1698	T2909	T2907	punct	),3c
R1699	T2910	T2884	punct	.,receive
R17	T204	T201	compound	ear,innervation
R170	T378	T379	compound	hair,cells
R1700	T2912	T2913	advmod	However,extend
R1701	T2914	T2913	punct	", ",extend
R1702	T2915	T2916	det	no,fibers
R1703	T2916	T2913	nsubj	fibers,extend
R1704	T2917	T2913	prep	to,extend
R1705	T2918	T2919	det	the,region
R1706	T2919	T2917	pobj	region,to
R1707	T2920	T2919	amod	outer,region
R1708	T2921	T2922	compound	hair,cell
R1709	T2922	T2919	compound	cell,region
R171	T379	T377	pobj	cells,of
R1710	T2923	T2913	prep	in,extend
R1711	T2924	T2925	nmod	Brn3c,mutants
R1712	T2925	T2923	pobj	mutants,in
R1713	T2926	T2925	amod	null,mutants
R1714	T2927	T2928	punct	(,3f
R1715	T2928	T2913	parataxis	3f,extend
R1716	T2929	T2928	nmod	Figs.,3f
R1717	T2930	T2928	nmod	3d,3f
R1718	T2931	T2928	punct	",",3f
R1719	T2932	T2928	nmod	3e,3f
R172	T380	T381	punct	(,%
R1720	T2933	T2928	punct	",",3f
R1721	T2934	T2928	punct	),3f
R1722	T2935	T2913	punct	.,extend
R1723	T2937	T2938	prep	In,is
R1724	T2939	T2940	compound	control,animals
R1725	T2940	T2937	pobj	animals,In
R1726	T2941	T2938	expl	there,is
R1727	T2942	T2943	amod	dense,innervation
R1728	T2943	T2938	attr	innervation,is
R1729	T2944	T2943	prep	of,innervation
R173	T381	T376	parataxis	%,loss
R1730	T2945	T2946	amod	inner,cells
R1731	T2946	T2944	pobj	cells,of
R1732	T2947	T2946	compound	hair,cells
R1733	T2948	T2938	punct	", ",is
R1734	T2949	T2950	mark	whereas,show
R1735	T2950	T2938	advcl	show,is
R1736	T2951	T2952	nmod	Brn3c,mutants
R1737	T2952	T2950	nsubj	mutants,show
R1738	T2953	T2952	amod	null,mutants
R1739	T2954	T2955	det	a,aggregation
R174	T382	T381	nummod	1,%
R1740	T2955	T2950	dobj	aggregation,show
R1741	T2956	T2955	amod	curious,aggregation
R1742	T2957	T2955	prep	of,aggregation
R1743	T2958	T2957	pobj	fibers,of
R1744	T2959	T2955	prep	near,aggregation
R1745	T2960	T2961	amod	focal,spots
R1746	T2961	T2959	pobj	spots,near
R1747	T2962	T2961	prep	around,spots
R1748	T2963	T2964	det	the,perforata
R1749	T2964	T2962	pobj	perforata,around
R175	T383	T381	prep	compared,%
R1750	T2965	T2964	compound	habenula,perforata
R1751	T2966	T2938	punct	.,is
R1752	T2968	T2969	det	The,apex
R1753	T2969	T2970	nsubj	apex,shows
R1754	T2971	T2972	advmod	less,pronounced
R1755	T2972	T2973	amod	pronounced,deviations
R1756	T2973	T2970	dobj	deviations,shows
R1757	T2974	T2973	prep	from,deviations
R1758	T2975	T2974	pobj	normal,from
R1759	T2976	T2977	punct	(,3g
R176	T384	T383	prep	to,compared
R1760	T2977	T2970	parataxis	3g,shows
R1761	T2978	T2977	nmod	Fig.,3g
R1762	T2979	T2977	nmod	3f,3g
R1763	T2980	T2977	punct	",",3g
R1764	T2981	T2977	punct	),3g
R1765	T2982	T2970	punct	.,shows
R1766	T2984	T2985	advmod	However,extend
R1767	T2986	T2985	punct	", ",extend
R1768	T2987	T2985	prep	as,extend
R1769	T2988	T2987	prep	in,as
R177	T385	T386	nummod	20,%
R1770	T2989	T2990	det	the,base
R1771	T2990	T2988	pobj	base,in
R1772	T2991	T2985	punct	", ",extend
R1773	T2992	T2985	nsubj	afferents,extend
R1774	T2993	T2992	cc	and,afferents
R1775	T2994	T2992	conj	efferents,afferents
R1776	T2995	T2985	advmod	sparingly,extend
R1777	T2996	T2985	prep	to,extend
R1778	T2997	T2998	det	the,region
R1779	T2998	T2996	pobj	region,to
R178	T386	T384	pobj	%,to
R1780	T2999	T2998	amod	outer,region
R1781	T3000	T3001	compound	hair,cell
R1782	T3001	T2998	compound	cell,region
R1783	T3002	T2985	punct	.,extend
R1784	T3004	T3005	expl	There,is
R1785	T3006	T3005	attr	formation,is
R1786	T3007	T3006	prep	of,formation
R1787	T3008	T3009	det	an,bundle
R1788	T3009	T3007	pobj	bundle,of
R1789	T3010	T3011	amod	inner,spiral
R179	T387	T381	punct	),%
R1790	T3011	T3009	nmod	spiral,bundle
R1791	T3012	T3009	acl	communicating,bundle
R1792	T3013	T3014	det	both,afferents
R1793	T3014	T3012	dobj	afferents,communicating
R1794	T3015	T3014	cc	and,afferents
R1795	T3016	T3014	conj	efferents,afferents
R1796	T3017	T3012	prep	between,communicating
R1797	T3018	T3019	det	the,points
R1798	T3019	T3017	pobj	points,between
R1799	T3020	T3019	amod	focal,points
R18	T209	T210	nsubj	Ears,develop
R180	T388	T373	punct	", ",retains
R1800	T3021	T3022	advmod	where,appear
R1801	T3022	T3019	relcl	appear,points
R1802	T3023	T3022	nsubj	fibers,appear
R1803	T3024	T3025	aux	to,pass
R1804	T3025	T3022	xcomp	pass,appear
R1805	T3026	T3025	prep	through,pass
R1806	T3027	T3028	det	the,perforata
R1807	T3028	T3026	pobj	perforata,through
R1808	T3029	T3028	compound	habenula,perforata
R1809	T3030	T3031	punct	(,3g
R181	T389	T390	det	the,cochlea
R1810	T3031	T3005	parataxis	3g,is
R1811	T3032	T3031	nmod	Fig.,3g
R1812	T3033	T3031	nummod	3f,3g
R1813	T3034	T3031	punct	",",3g
R1814	T3035	T3031	punct	),3g
R1815	T3036	T3005	punct	.,is
R1816	T3038	T3039	prep	As,follow
R1817	T3040	T3038	prep	in,As
R1818	T3041	T3042	amod	newborn,animals
R1819	T3042	T3040	pobj	animals,in
R182	T390	T373	nsubj	cochlea,retains
R1820	T3043	T3039	punct	", ",follow
R1821	T3044	T3045	amod	efferent,fibers
R1822	T3045	T3039	nsubj	fibers,follow
R1823	T3046	T3039	advmod	closely,follow
R1824	T3047	T3048	det	the,pattern
R1825	T3048	T3039	dobj	pattern,follow
R1826	T3049	T3048	prep	of,pattern
R1827	T3050	T3049	pobj	innervation,of
R1828	T3051	T3048	acl	displayed,pattern
R1829	T3052	T3051	agent	by,displayed
R183	T391	T392	amod	many,neurons
R1830	T3053	T3052	pobj	afferents,by
R1831	T3054	T3055	punct	(,shown
R1832	T3055	T3039	parataxis	shown,follow
R1833	T3056	T3055	nsubj	data,shown
R1834	T3057	T3055	neg	not,shown
R1835	T3058	T3055	punct	),shown
R1836	T3059	T3039	punct	.,follow
R1837	T3061	T3062	det	The,effect
R1838	T3062	T3065	nsubj	effect,is
R1839	T3063	T3062	amod	limited,effect
R184	T392	T373	dobj	neurons,retains
R1840	T3064	T3062	amod	qualitative,effect
R1841	T3066	T3062	prep	of,effect
R1842	T3067	T3068	nmod	Brn3c,mutations
R1843	T3068	T3066	pobj	mutations,of
R1844	T3069	T3068	amod	null,mutations
R1845	T3070	T3062	prep	on,effect
R1846	T3071	T3072	compound	fiber,loss
R1847	T3072	T3070	pobj	loss,on
R1848	T3073	T3074	advmod	particularly,obvious
R1849	T3074	T3065	acomp	obvious,is
R185	T393	T392	amod	more,neurons
R1850	T3075	T3065	prep	in,is
R1851	T3076	T3077	det	the,turn
R1852	T3077	T3075	pobj	turn,in
R1853	T3078	T3079	nmod	P8,Brn3c
R1854	T3079	T3077	nmod	Brn3c,turn
R1855	T3080	T3079	amod	null,Brn3c
R1856	T3081	T3079	amod	mutant,Brn3c
R1857	T3082	T3077	amod	apical,turn
R1858	T3083	T3084	punct	(,3g
R1859	T3084	T3065	parataxis	3g,is
R186	T394	T392	amod	sensory,neurons
R1860	T3085	T3084	compound	Fig.,3g
R1861	T3086	T3084	punct	),3g
R1862	T3087	T3065	punct	.,is
R1863	T3089	T3090	amod	Immunocytochemical,data
R1864	T3090	T3093	nsubj	data,show
R1865	T3091	T3089	cc	and,Immunocytochemical
R1866	T3092	T3089	conj	histochemcial,Immunocytochemical
R1867	T3094	T3095	det	the,presence
R1868	T3095	T3093	dobj	presence,show
R1869	T3096	T3095	prep	of,presence
R187	T395	T396	punct	(,%
R1870	T3097	T3098	advmod	only,few
R1871	T3098	T3100	nummod	few,cells
R1872	T3099	T3098	quantmod	a,few
R1873	T3100	T3096	pobj	cells,of
R1874	T3101	T3100	amod	immature,cells
R1875	T3102	T3100	compound	hair,cells
R1876	T3103	T3100	prep	in,cells
R1877	T3104	T3105	det	the,cochlea
R1878	T3105	T3103	pobj	cochlea,in
R1879	T3106	T3107	punct	(,Fig.
R188	T396	T392	parataxis	%,neurons
R1880	T3107	T3100	parataxis	Fig.,cells
R1881	T3108	T3107	nummod	4,Fig.
R1882	T3109	T3107	punct	),Fig.
R1883	T3110	T3100	punct	", ",cells
R1884	T3111	T3112	dep	which,amounted
R1885	T3112	T3100	relcl	amounted,cells
R1886	T3113	T3112	prep	to,amounted
R1887	T3114	T3115	quantmod	about,1
R1888	T3115	T3116	nummod	1,%
R1889	T3116	T3113	pobj	%,to
R189	T397	T396	nummod	46,%
R1890	T3117	T3118	punct	(,1
R1891	T3118	T3112	parataxis	1,amounted
R1892	T3119	T3118	amod	Table,1
R1893	T3120	T3118	punct	),1
R1894	T3121	T3093	punct	.,show
R1895	T3123	T3124	neg	Not,single
R1896	T3124	T3126	nummod	single,cell
R1897	T3125	T3124	quantmod	a,single
R1898	T3126	T3129	nsubj	cell,forms
R1899	T3127	T3126	amod	immature,cell
R19	T211	T209	prep	of,Ears
R190	T398	T396	prep	compared,%
R1900	T3128	T3126	compound	hair,cell
R1901	T3130	T3129	prep	in,forms
R1902	T3131	T3132	det	the,apex
R1903	T3132	T3130	pobj	apex,in
R1904	T3133	T3132	prep	of,apex
R1905	T3134	T3135	det	the,cochlea
R1906	T3135	T3133	pobj	cochlea,of
R1907	T3136	T3129	punct	.,forms
R1908	T3138	T3139	prep	In,found
R1909	T3140	T3138	pobj	contrast,In
R191	T399	T398	prep	to,compared
R1910	T3141	T3139	punct	", ",found
R1911	T3142	T3143	advmod	more,cells
R1912	T3143	T3139	nsubjpass	cells,found
R1913	T3144	T3143	amod	immature,cells
R1914	T3145	T3143	compound	hair,cells
R1915	T3146	T3139	auxpass	are,found
R1916	T3147	T3139	prep	in,found
R1917	T3148	T3149	det	the,position
R1918	T3149	T3147	pobj	position,in
R1919	T3150	T3149	amod	appropriate,position
R192	T400	T401	nummod	15,%
R1920	T3151	T3149	prep	of,position
R1921	T3152	T3153	compound	hair,cells
R1922	T3153	T3151	pobj	cells,of
R1923	T3154	T3139	prep	in,found
R1924	T3155	T3156	det	the,endorgans
R1925	T3156	T3154	pobj	endorgans,in
R1926	T3157	T3156	amod	vestibular,endorgans
R1927	T3158	T3159	punct	(,1
R1928	T3159	T3139	parataxis	1,found
R1929	T3160	T3159	amod	Table,1
R193	T401	T399	pobj	%,to
R1930	T3161	T3159	punct	),1
R1931	T3162	T3139	punct	.,found
R1932	T3164	T3165	prep	In,show
R1933	T3166	T3164	pobj	fact,In
R1934	T3167	T3165	punct	", ",show
R1935	T3168	T3169	det	the,organs
R1936	T3169	T3165	nsubj	organs,show
R1937	T3170	T3169	amod	vestibular,organs
R1938	T3171	T3169	compound	end,organs
R1939	T3172	T3173	det	no,defect
R194	T402	T396	punct	),%
R1940	T3173	T3165	dobj	defect,show
R1941	T3174	T3173	amod	overt,defect
R1942	T3175	T3173	amod	morphological,defect
R1943	T3176	T3173	advmod	other,defect
R1944	T3177	T3176	prep	than,other
R1945	T3178	T3179	det	the,presence
R1946	T3179	T3177	pobj	presence,than
R1947	T3180	T3179	amod	reduced,presence
R1948	T3181	T3179	prep	of,presence
R1949	T3182	T3183	det	these,cells
R195	T403	T392	prep	than,neurons
R1950	T3183	T3181	pobj	cells,of
R1951	T3184	T3183	amod	immature,cells
R1952	T3185	T3183	compound	hair,cells
R1953	T3186	T3165	punct	.,show
R1954	T3188	T3189	compound	Nerve,fibers
R1955	T3189	T3190	nsubjpass	fibers,traced
R1956	T3191	T3190	aux	can,traced
R1957	T3192	T3190	auxpass	be,traced
R1958	T3193	T3190	prep	into,traced
R1959	T3194	T3195	det	the,epithelium
R196	T404	T405	amod	vestibular,epithelia
R1960	T3195	T3193	pobj	epithelium,into
R1961	T3196	T3195	amod	sensory,epithelium
R1962	T3197	T3195	prep	of,epithelium
R1963	T3198	T3199	nmod	P0,mutants
R1964	T3199	T3197	pobj	mutants,of
R1965	T3200	T3198	cc	and,P0
R1966	T3201	T3198	conj	P8,P0
R1967	T3202	T3203	npadvmod	Brn3c,null
R1968	T3203	T3199	amod	null,mutants
R1969	T3204	T3190	prep	past,traced
R197	T405	T403	pobj	epithelia,than
R1970	T3205	T3206	det	the,perforata
R1971	T3206	T3204	pobj	perforata,past
R1972	T3207	T3206	compound	habenula,perforata
R1973	T3208	T3190	cc	and,traced
R1974	T3209	T3210	expl	there,is
R1975	T3210	T3190	conj	is,traced
R1976	T3211	T3212	det	a,location
R1977	T3212	T3210	attr	location,is
R1978	T3213	T3212	amod	normal,location
R1979	T3214	T3212	prep	of,location
R198	T406	T373	punct	.,retains
R1980	T3215	T3216	amod	spiral,neurons
R1981	T3216	T3214	pobj	neurons,of
R1982	T3217	T3216	amod	sensory,neurons
R1983	T3218	T3210	prep	in,is
R1984	T3219	T3220	poss	Rosenthal,canal
R1985	T3220	T3218	pobj	canal,in
R1986	T3221	T3219	case	's,Rosenthal
R1987	T3222	T3210	prep	in,is
R1988	T3223	T3224	det	the,apex
R1989	T3224	T3222	pobj	apex,in
R199	T408	T409	advmod	Even,mice
R1990	T3225	T3224	prep	of,apex
R1991	T3226	T3227	nmod	P8,mutants
R1992	T3227	T3225	pobj	mutants,of
R1993	T3228	T3227	nmod	Brn3c,mutants
R1994	T3229	T3227	amod	null,mutants
R1995	T3230	T3231	punct	(,3g
R1996	T3231	T3210	parataxis	3g,is
R1997	T3232	T3231	nmod	Fig.,3g
R1998	T3233	T3231	nummod	3d,3g
R1999	T3234	T3231	punct	",",3g
R20	T212	T213	nmod	Brn3c,mutants
R200	T409	T414	nsubj	mice,have
R2000	T3235	T3231	punct	),3g
R2001	T3236	T3210	punct	.,is
R2002	T3238	T3239	det	The,cochlea
R2003	T3239	T3240	nsubj	cochlea,shows
R2004	T3241	T3242	amod	other,defects
R2005	T3242	T3240	dobj	defects,shows
R2006	T3243	T3244	advmod	as,well
R2007	T3244	T3240	advmod	well,shows
R2008	T3245	T3240	punct	.,shows
R2009	T3247	T3248	prep	For,found
R201	T410	T411	nummod	6,months
R2010	T3249	T3247	pobj	example,For
R2011	T3250	T3248	punct	", ",found
R2012	T3251	T3252	det	the,capillary
R2013	T3252	T3248	nsubjpass	capillary,found
R2014	T3253	T3252	amod	spiral,capillary
R2015	T3254	T3248	auxpass	is,found
R2016	T3255	T3248	neg	not,found
R2017	T3256	T3248	prep	underneath,found
R2018	T3257	T3258	det	the,organ
R2019	T3258	T3256	pobj	organ,underneath
R202	T411	T412	npadvmod	months,old
R2020	T3259	T3258	prep	of,organ
R2021	T3260	T3259	pobj	Corti,of
R2022	T3261	T3256	cc	but,underneath
R2023	T3262	T3256	conj	in,underneath
R2024	T3263	T3264	det	the,limbus
R2025	T3264	T3262	pobj	limbus,in
R2026	T3265	T3264	amod	spiral,limbus
R2027	T3266	T3264	amod	nearby,limbus
R2028	T3267	T3268	punct	(,Fig.
R2029	T3268	T3248	parataxis	Fig.,found
R203	T412	T409	amod	old,mice
R2030	T3269	T3268	nummod	4,Fig.
R2031	T3270	T3268	punct	),Fig.
R2032	T3271	T3248	punct	.,found
R2033	T3273	T3274	det	The,lack
R2034	T3274	T3275	nsubj	lack,seems
R2035	T3276	T3274	prep	of,lack
R2036	T3277	T3278	amod	immature,cells
R2037	T3278	T3276	pobj	cells,of
R2038	T3279	T3278	compound	hair,cells
R2039	T3280	T3281	aux	to,affect
R204	T413	T409	amod	mutant,mice
R2040	T3281	T3275	xcomp	affect,seems
R2041	T3282	T3281	advmod	also,affect
R2042	T3283	T3284	det	the,formation
R2043	T3284	T3281	dobj	formation,affect
R2044	T3285	T3284	prep	of,formation
R2045	T3286	T3287	amod	pillar,cells
R2046	T3287	T3285	pobj	cells,of
R2047	T3288	T3287	punct	(,cells
R2048	T3289	T3287	relcl	undifferentiated,cells
R2049	T3290	T3291	advmod	almost,throughout
R205	T415	T416	det	some,fibers
R2050	T3291	T3289	prep	throughout,undifferentiated
R2051	T3292	T3293	det	the,cochlea
R2052	T3293	T3291	pobj	cochlea,throughout
R2053	T3294	T3295	punct	;,Fig.
R2054	T3295	T3287	parataxis	Fig.,cells
R2055	T3296	T3295	nummod	4,Fig.
R2056	T3297	T3295	punct	),Fig.
R2057	T3298	T3287	cc	and,cells
R2058	T3299	T3300	poss	Deiters,cells
R2059	T3300	T3287	conj	cells,cells
R206	T416	T414	dobj	fibers,have
R2060	T3301	T3299	case	',Deiters
R2061	T3302	T3300	punct	(,cells
R2062	T3303	T3304	neg	not,recognizable
R2063	T3304	T3300	relcl	recognizable,cells
R2064	T3305	T3304	prep	based,recognizable
R2065	T3306	T3305	prep	on,based
R2066	T3307	T3308	poss	their,morphology
R2067	T3308	T3306	pobj	morphology,on
R2068	T3309	T3300	punct	),cells
R2069	T3310	T3275	punct	", ",seems
R207	T417	T416	prep	to,fibers
R2070	T3311	T3312	det	a,suggestion
R2071	T3312	T3275	npadvmod	suggestion,seems
R2072	T3313	T3312	amod	consistent,suggestion
R2073	T3314	T3313	prep	with,consistent
R2074	T3315	T3316	amod	recent,data
R2075	T3316	T3314	pobj	data,with
R2076	T3317	T3316	amod	molecular,data
R2077	T3318	T3316	prep	on,data
R2078	T3319	T3320	det	the,interaction
R2079	T3320	T3318	pobj	interaction,on
R208	T418	T419	det	all,epithelia
R2080	T3321	T3320	prep	of,interaction
R2081	T3322	T3323	compound	hair,cells
R2082	T3323	T3321	pobj	cells,of
R2083	T3324	T3323	cc	and,cells
R2084	T3325	T3326	amod	supporting,cells
R2085	T3326	T3323	conj	cells,cells
R2086	T3327	T3328	punct	[,18
R2087	T3328	T3275	parataxis	18,seems
R2088	T3329	T3328	nummod	17,18
R2089	T3330	T3328	punct	",",18
R209	T419	T417	pobj	epithelia,to
R2090	T3331	T3328	punct	],18
R2091	T3332	T3275	punct	.,seems
R2092	T3342	T3341	amod	ar,s
R2093	T3343	T3341	compound	i,s
R2094	T3345	T3346	nsubj	on,o
R2095	T3348	T3347	pobj	n,f
R2096	T3349	T3350	compound	u,m
R2097	T3352	T3353	nsubj	be,rs
R2098	T3362	T3361	prep	i,a
R2099	T3366	T3364	prep	in,r
R21	T213	T211	pobj	mutants,of
R210	T420	T419	amod	vestibular,epithelia
R2100	T3374	T3373	amod	vestibular,areas
R2101	T3375	T3374	cc	and,vestibular
R2102	T3376	T3374	conj	cochlear,vestibular
R2103	T3377	T3378	punct	(,4
R2104	T3378	T3372	parataxis	4,e
R2105	T3379	T3378	dep	Fig.,4
R2106	T3380	T3378	punct	),4
R2107	T3382	T3383	det	the,numbers
R2108	T3383	T3381	pobj	numbers,with
R2109	T3384	T3383	prep	of,numbers
R211	T421	T419	amod	sensory,epithelia
R2110	T3385	T3386	amod	surviving,neurons
R2111	T3386	T3384	pobj	neurons,of
R2112	T3387	T3386	amod	vestibular,neurons
R2113	T3388	T3387	cc	and,vestibular
R2114	T3389	T3387	conj	cochlear,vestibular
R2115	T3390	T3386	amod	sensory,neurons
R2116	T3391	T3371	aux	does,show
R2117	T3392	T3371	neg	not,show
R2118	T3393	T3394	det	any,correlation
R2119	T3394	T3371	dobj	correlation,show
R212	T422	T416	cc	and,fibers
R2120	T3395	T3396	punct	(,Fig.
R2121	T3396	T3371	parataxis	Fig.,show
R2122	T3397	T3398	amod	Table,1
R2123	T3398	T3396	dep	1,Fig.
R2124	T3399	T3396	punct	;,Fig.
R2125	T3400	T3396	nummod	5,Fig.
R2126	T3401	T3396	punct	),Fig.
R2127	T3402	T3371	punct	.,show
R2128	T3404	T3405	advmod	Only,few
R2129	T3405	T3407	nummod	few,cells
R213	T423	T424	amod	many,more
R2130	T3406	T3405	quantmod	a,few
R2131	T3407	T3410	nsubjpass	cells,detected
R2132	T3408	T3407	amod	undifferentiated,cells
R2133	T3409	T3407	compound	hair,cells
R2134	T3411	T3410	auxpass	were,detected
R2135	T3412	T3410	prep	by,detected
R2136	T3413	T3414	compound	MyoVIIa,immunostaining
R2137	T3414	T3412	pobj	immunostaining,by
R2138	T3415	T3410	cc	and,detected
R2139	T3416	T3417	advmod	only,in
R214	T424	T416	conj	more,fibers
R2140	T3417	T3415	prep	in,and
R2141	T3418	T3419	det	the,region
R2142	T3419	T3417	pobj	region,in
R2143	T3420	T3419	amod	basal,region
R2144	T3421	T3419	prep	of,region
R2145	T3422	T3423	det	the,cochlea
R2146	T3423	T3421	pobj	cochlea,of
R2147	T3424	T3410	punct	.,detected
R2148	T3426	T3427	cc	And,lost
R2149	T3428	T3427	advmod	yet,lost
R215	T425	T424	prep	to,more
R2150	T3429	T3430	advmod	only,50
R2151	T3430	T3432	nummod	50,%
R2152	T3431	T3430	quantmod	about,50
R2153	T3432	T3427	nsubjpass	%,lost
R2154	T3433	T3432	prep	of,%
R2155	T3434	T3435	amod	cochlear,neurons
R2156	T3435	T3433	pobj	neurons,of
R2157	T3436	T3435	amod	sensory,neurons
R2158	T3437	T3427	auxpass	are,lost
R2159	T3438	T3427	advmod	overall,lost
R216	T426	T427	det	the,apex
R2160	T3439	T3427	prep	with,lost
R2161	T3440	T3441	det	a,loss
R2162	T3441	T3439	pobj	loss,with
R2163	T3442	T3443	advmod	less,severe
R2164	T3443	T3441	amod	severe,loss
R2165	T3444	T3441	prep	in,loss
R2166	T3445	T3446	det	the,apex
R2167	T3446	T3444	pobj	apex,in
R2168	T3447	T3448	prep	in,detect
R2169	T3448	T3446	relcl	detect,apex
R217	T427	T425	pobj	apex,to
R2170	T3449	T3447	pobj	which,in
R2171	T3450	T3448	nsubj	we,detect
R2172	T3451	T3448	aux	could,detect
R2173	T3452	T3448	neg	not,detect
R2174	T3453	T3454	det	any,cells
R2175	T3454	T3448	dobj	cells,detect
R2176	T3455	T3454	amod	immature,cells
R2177	T3456	T3454	compound	hair,cells
R2178	T3457	T3448	prep	with,detect
R2179	T3458	T3459	compound	MyoVIIa,immunocytochemistry
R218	T428	T427	amod	cochlear,apex
R2180	T3459	T3457	pobj	immunocytochemistry,with
R2181	T3460	T3427	punct	.,lost
R2182	T3462	T3463	nsubj	This,exclude
R2183	T3464	T3463	aux	does,exclude
R2184	T3465	T3463	neg	not,exclude
R2185	T3466	T3467	det	the,possibility
R2186	T3467	T3463	dobj	possibility,exclude
R2187	T3468	T3469	mark	that,form
R2188	T3469	T3467	acl	form,possibility
R2189	T3470	T3471	advmod	even,less
R219	T429	T430	dep	which,lacks
R2190	T3471	T3472	advmod	less,differentiated
R2191	T3472	T3473	amod	differentiated,cells
R2192	T3473	T3469	nsubj	cells,form
R2193	T3474	T3473	compound	hair,cells
R2194	T3475	T3469	aux	may,form
R2195	T3476	T3469	prep	in,form
R2196	T3477	T3478	det	the,apex
R2197	T3478	T3476	pobj	apex,in
R2198	T3479	T3463	punct	.,exclude
R2199	T3481	T3482	det	The,projection
R22	T214	T213	amod	null,mutants
R220	T430	T427	relcl	lacks,apex
R2200	T3482	T3484	nsubj	projection,traces
R2201	T3483	T3482	amod	central,projection
R2202	T3485	T3482	prep	of,projection
R2203	T3486	T3485	pobj	DiI,of
R2204	T3487	T3486	cc	and,DiI
R2205	T3488	T3486	conj	DiA,DiI
R2206	T3489	T3484	dobj	fibers,traces
R2207	T3490	T3484	prep	to,traces
R2208	T3491	T3492	det	the,nuclei
R2209	T3492	T3490	pobj	nuclei,to
R221	T431	T432	npadvmod	MyoVIIa,positive
R2210	T3493	T3492	amod	cochlear,nuclei
R2211	T3494	T3495	punct	(,Fig.
R2212	T3495	T3492	parataxis	Fig.,nuclei
R2213	T3496	T3495	nummod	6,Fig.
R2214	T3497	T3495	punct	),Fig.
R2215	T3498	T3499	advmod	where,show
R2216	T3499	T3492	relcl	show,nuclei
R2217	T3500	T3499	nsubj	they,show
R2218	T3501	T3502	det	a,segregation
R2219	T3502	T3499	dobj	segregation,show
R222	T432	T433	amod	positive,cells
R2220	T3503	T3502	amod	clear,segregation
R2221	T3504	T3502	prep	of,segregation
R2222	T3505	T3506	amod	apical,turn
R2223	T3506	T3507	compound	turn,afferents
R2224	T3507	T3504	pobj	afferents,of
R2225	T3508	T3509	punct	(,Fig.
R2226	T3509	T3507	parataxis	Fig.,afferents
R2227	T3510	T3509	nummod	6,Fig.
R2228	T3511	T3509	punct	", ",Fig.
R2229	T3512	T3509	amod	green,Fig.
R223	T433	T430	dobj	cells,lacks
R2230	T3513	T3509	punct	),Fig.
R2231	T3514	T3507	cc	and,afferents
R2232	T3515	T3516	amod	basal,turn
R2233	T3516	T3517	compound	turn,afferents
R2234	T3517	T3507	conj	afferents,afferents
R2235	T3518	T3519	punct	(,Fig.
R2236	T3519	T3517	parataxis	Fig.,afferents
R2237	T3520	T3519	nummod	6,Fig.
R2238	T3521	T3519	punct	", ",Fig.
R2239	T3522	T3519	amod	red,Fig.
R224	T434	T433	compound	hair,cells
R2240	T3523	T3519	punct	),Fig.
R2241	T3524	T3502	prep	in,segregation
R2242	T3525	T3526	preconj	both,nerve
R2243	T3526	T3524	pobj	nerve,in
R2244	T3527	T3526	det	the,nerve
R2245	T3528	T3526	amod	entering,nerve
R2246	T3529	T3526	amod	cochlear,nerve
R2247	T3530	T3531	punct	(,6a
R2248	T3531	T3526	parataxis	6a,nerve
R2249	T3532	T3531	compound	Fig.,6a
R225	T435	T414	punct	.,have
R2250	T3533	T3531	punct	),6a
R2251	T3534	T3526	cc	and,nerve
R2252	T3535	T3536	det	the,nucleus
R2253	T3536	T3526	conj	nucleus,nerve
R2254	T3537	T3536	amod	ventral,nucleus
R2255	T3538	T3536	amod	cochlear,nucleus
R2256	T3539	T3536	punct	(,nucleus
R2257	T3540	T3536	appos	VCN,nucleus
R2258	T3541	T3536	punct	),nucleus
R2259	T3542	T3543	punct	(,6b
R226	T437	T438	advmod	Topologically,organized
R2260	T3543	T3536	parataxis	6b,nucleus
R2261	T3544	T3543	compound	Fig.,6b
R2262	T3545	T3543	punct	),6b
R2263	T3546	T3484	punct	.,traces
R2264	T3548	T3549	amod	Qualitative,projections
R2265	T3549	T3552	nsubjpass	projections,found
R2266	T3550	T3549	amod	comparable,projections
R2267	T3551	T3549	amod	central,projections
R2268	T3553	T3552	auxpass	are,found
R2269	T3554	T3552	prep	in,found
R227	T438	T439	amod	organized,projections
R2270	T3555	T3556	amod	wildtype,littermates
R2271	T3556	T3554	pobj	littermates,in
R2272	T3557	T3556	compound	control,littermates
R2273	T3558	T3559	punct	(,shown
R2274	T3559	T3552	parataxis	shown,found
R2275	T3560	T3559	nsubj	data,shown
R2276	T3561	T3559	neg	not,shown
R2277	T3562	T3559	punct	),shown
R2278	T3563	T3552	cc	and,found
R2279	T3564	T3552	conj	suggest,found
R228	T439	T442	nsubj	projections,exist
R2280	T3565	T3566	mark	that,is
R2281	T3566	T3564	ccomp	is,suggest
R2282	T3567	T3568	det	the,projection
R2283	T3568	T3566	nsubj	projection,is
R2284	T3569	T3568	amod	central,projection
R2285	T3570	T3568	prep	to,projection
R2286	T3571	T3572	amod	cochlear,nuclei
R2287	T3572	T3570	pobj	nuclei,to
R2288	T3573	T3574	advmod	at,least
R2289	T3574	T3575	advmod	least,until
R229	T440	T441	amod	central,cochlea
R2290	T3575	T3566	prep	until,is
R2291	T3576	T3575	pobj	P8,until
R2292	T3577	T3566	prep	in,is
R2293	T3578	T3577	pobj	mice,in
R2294	T3579	T3566	neg	not,is
R2295	T3580	T3581	advmod	critically,dependent
R2296	T3581	T3566	acomp	dependent,is
R2297	T3582	T3581	prep	on,dependent
R2298	T3583	T3584	amod	auditory,information
R2299	T3584	T3582	pobj	information,on
R23	T215	T216	amod	immature,cells
R230	T441	T439	compound	cochlea,projections
R2300	T3585	T3584	cc	or,information
R2301	T3586	T3587	amod	other,influences
R2302	T3587	T3584	conj	influences,information
R2303	T3588	T3589	npadvmod	hair,mediated
R2304	T3589	T3587	amod	mediated,influences
R2305	T3590	T3588	amod	cell,hair
R2306	T3591	T3589	punct	-,mediated
R2307	T3592	T3566	punct	", ",is
R2308	T3593	T3566	prep	in,is
R2309	T3594	T3593	pobj	agreement,in
R231	T443	T444	advmod	at,least
R2310	T3595	T3594	prep	with,agreement
R2311	T3596	T3597	amod	recent,suggestions
R2312	T3597	T3595	pobj	suggestions,with
R2313	T3598	T3599	punct	[,19
R2314	T3599	T3566	parataxis	19,is
R2315	T3600	T3599	nummod	5,19
R2316	T3601	T3599	punct	",",19
R2317	T3602	T3599	punct	],19
R2318	T3603	T3552	punct	.,found
R232	T444	T445	advmod	least,until
R2321	T3723	T3724	nummod	6,months
R2322	T3724	T3725	nmod	months,mutants
R2323	T3726	T3727	npadvmod	Brn3c,null
R2324	T3727	T3725	amod	null,mutants
R2325	T3729	T3730	amod	Very,few
R2326	T3730	T3731	amod	few,fibers
R2327	T3731	T3732	nsubj	fibers,remain
R2328	T3733	T3731	punct	(,fibers
R2329	T3734	T3735	preconj	both,afferent
R233	T445	T442	prep	until,exist
R2330	T3735	T3731	amod	afferent,fibers
R2331	T3736	T3735	cc	and,afferent
R2332	T3737	T3735	conj	efferent,afferent
R2333	T3738	T3731	punct	),fibers
R2334	T3739	T3731	prep	to,fibers
R2335	T3740	T3741	det	the,epithelia
R2336	T3741	T3739	pobj	epithelia,to
R2337	T3742	T3741	amod	vestibular,epithelia
R2338	T3743	T3744	punct	(,7a
R2339	T3744	T3732	parataxis	7a,remain
R234	T446	T445	pobj	P8,until
R2340	T3745	T3744	compound	Fig.,7a
R2341	T3746	T3744	punct	),7a
R2342	T3747	T3732	punct	", ",remain
R2343	T3748	T3749	advmod	thus,displaying
R2344	T3749	T3732	advcl	displaying,remain
R2345	T3750	T3751	det	a,reduction
R2346	T3751	T3749	dobj	reduction,displaying
R2347	T3752	T3751	amod	further,reduction
R2348	T3753	T3751	prep	of,reduction
R2349	T3754	T3755	det	the,pattern
R235	T447	T442	punct	", ",exist
R2350	T3755	T3753	pobj	pattern,of
R2351	T3756	T3755	prep	of,pattern
R2352	T3757	T3756	pobj	innervation,of
R2353	T3758	T3755	acl	found,pattern
R2354	T3759	T3758	prep	in,found
R2355	T3760	T3761	nmod	P8,mutants
R2356	T3761	T3759	pobj	mutants,in
R2357	T3762	T3761	nmod	Brn3c,mutants
R2358	T3763	T3761	amod	null,mutants
R2359	T3764	T3732	punct	.,remain
R236	T448	T442	advcl	suggesting,exist
R2360	T3766	T3767	advmod	Notably,are
R2361	T3768	T3767	punct	", ",are
R2362	T3769	T3767	expl	there,are
R2363	T3770	T3767	advmod	still,are
R2364	T3771	T3772	det	a,number
R2365	T3772	T3767	attr	number,are
R2366	T3773	T3772	prep	of,number
R2367	T3774	T3773	pobj	fibers,of
R2368	T3775	T3774	acl	extending,fibers
R2369	T3776	T3775	prep	from,extending
R237	T449	T450	mark	that,required
R2370	T3777	T3778	det	the,neurons
R2371	T3778	T3776	pobj	neurons,from
R2372	T3779	T3780	advmod	very,few
R2373	T3780	T3778	amod	few,neurons
R2374	T3781	T3778	amod	vestibular,neurons
R2375	T3782	T3778	amod	sensory,neurons
R2376	T3783	T3775	prep	to,extending
R2377	T3784	T3785	det	the,epithelia
R2378	T3785	T3783	pobj	epithelia,to
R2379	T3786	T3785	amod	canal,epithelia
R238	T450	T448	ccomp	required,suggesting
R2380	T3787	T3785	punct	", ",epithelia
R2381	T3788	T3789	prep	in,canal
R2382	T3789	T3785	appos	canal,epithelia
R2383	T3790	T3788	amod	particular,in
R2384	T3791	T3789	det	the,canal
R2385	T3792	T3789	amod	horizontal,canal
R2386	T3793	T3794	punct	(,7b
R2387	T3794	T3767	parataxis	7b,are
R2388	T3795	T3794	nmod	Fig.,7b
R2389	T3796	T3794	nmod	7a,7b
R239	T451	T452	amod	functional,cells
R2390	T3797	T3794	punct	",",7b
R2391	T3798	T3794	punct	),7b
R2392	T3799	T3767	punct	.,are
R2393	T3801	T3802	advmod	Only,fibers
R2394	T3802	T3805	nsubj	fibers,extend
R2395	T3803	T3804	advmod	very,few
R2396	T3804	T3802	amod	few,fibers
R2397	T3806	T3805	prep	to,extend
R2398	T3807	T3808	det	the,utricle
R2399	T3808	T3806	pobj	utricle,to
R24	T216	T210	dobj	cells,develop
R240	T452	T450	nsubjpass	cells,required
R2400	T3809	T3808	cc	and,utricle
R2401	T3810	T3808	conj	saccule,utricle
R2402	T3811	T3805	prep	with,extend
R2403	T3812	T3813	det	the,reduction
R2404	T3813	T3814	nsubj	reduction,being
R2405	T3814	T3811	pcomp	being,with
R2406	T3815	T3813	prep	of,reduction
R2407	T3816	T3815	pobj	efferents,of
R2408	T3817	T3813	prep	to,reduction
R2409	T3818	T3819	det	these,epithelia
R241	T453	T452	compound	hair,cells
R2410	T3819	T3817	pobj	epithelia,to
R2411	T3820	T3821	advmod	almost,complete
R2412	T3821	T3814	acomp	complete,being
R2413	T3822	T3823	punct	(,7a
R2414	T3823	T3805	parataxis	7a,extend
R2415	T3824	T3823	compound	Fig.,7a
R2416	T3825	T3823	cc	and,7a
R2417	T3826	T3827	nsubj	data,shown
R2418	T3827	T3823	conj	shown,7a
R2419	T3828	T3827	neg	not,shown
R242	T454	T450	auxpass	are,required
R2420	T3829	T3827	punct	),shown
R2421	T3830	T3805	punct	.,extend
R2422	T3832	T3833	advcl	Comparable,is
R2423	T3834	T3832	prep	to,Comparable
R2424	T3835	T3836	compound	control,mice
R2425	T3836	T3834	pobj	mice,to
R2426	T3837	T3833	punct	", ",is
R2427	T3838	T3833	expl	there,is
R2428	T3839	T3840	det	some,labeling
R2429	T3840	T3833	attr	labeling,is
R243	T455	T450	neg	not,required
R2430	T3841	T3840	amod	transcellular,labeling
R2431	T3842	T3840	prep	with,labeling
R2432	T3843	T3842	pobj	DiI,with
R2433	T3844	T3840	prep	to,labeling
R2434	T3845	T3844	pobj	cells,to
R2435	T3846	T3847	advmod	apparently,contacted
R2436	T3847	T3845	acl	contacted,cells
R2437	T3848	T3847	agent	by,contacted
R2438	T3849	T3850	det	the,fibers
R2439	T3850	T3848	pobj	fibers,by
R244	T456	T457	aux	to,establish
R2440	T3851	T3850	amod	afferent,fibers
R2441	T3852	T3847	prep	in,contacted
R2442	T3853	T3854	det	the,utricle
R2443	T3854	T3852	pobj	utricle,in
R2444	T3855	T3856	npadvmod	Brn3c,null
R2445	T3856	T3854	amod	null,utricle
R2446	T3857	T3854	amod	mutant,utricle
R2447	T3858	T3859	punct	(,7b
R2448	T3859	T3833	parataxis	7b,is
R2449	T3860	T3859	compound	Fig.,7b
R245	T457	T450	advcl	establish,required
R2450	T3861	T3859	punct	),7b
R2451	T3862	T3833	punct	.,is
R2452	T3864	T3865	advmod	However,identified
R2453	T3866	T3865	punct	", ",identified
R2454	T3867	T3868	det	these,cells
R2455	T3868	T3865	nsubjpass	cells,identified
R2456	T3869	T3865	aux	could,identified
R2457	T3870	T3865	neg	not,identified
R2458	T3871	T3865	auxpass	be,identified
R2459	T3872	T3865	advmod	clearly,identified
R246	T458	T459	amod	such,projections
R2460	T3873	T3865	prep	as,identified
R2461	T3874	T3875	amod	immature,cells
R2462	T3875	T3873	pobj	cells,as
R2463	T3876	T3875	compound	hair,cells
R2464	T3877	T3865	prep	based,identified
R2465	T3878	T3877	prep	on,based
R2466	T3879	T3880	poss	their,morphology
R2467	T3880	T3878	pobj	morphology,on
R2468	T3881	T3865	punct	.,identified
R2469	T3896	T3897	nsubj	o,s
R247	T459	T457	dobj	projections,establish
R2470	T3898	T3897	dobj	t,s
R2471	T3909	T3910	nsubj	l,receives
R2472	T3911	T3912	advmod	y,apex
R2473	T3912	T3909	appos	apex,l
R2474	T3913	T3912	det	the,apex
R2475	T3914	T3910	punct	", ",receives
R2476	T3915	T3916	amod	many,fibers
R2477	T3916	T3910	dobj	fibers,receives
R2478	T3917	T3916	amod	afferent,fibers
R2479	T3918	T3916	punct	", ",fibers
R248	T460	T442	punct	.,exist
R2480	T3919	T3920	dep	which,form
R2481	T3920	T3916	relcl	form,fibers
R2482	T3921	T3922	det	an,bundle
R2483	T3922	T3920	dobj	bundle,form
R2484	T3923	T3922	amod	interrupted,bundle
R2485	T3924	T3925	amod	inner,spiral
R2486	T3925	T3922	nmod	spiral,bundle
R2487	T3926	T3927	punct	(,7c
R2488	T3927	T3910	parataxis	7c,receives
R2489	T3928	T3927	compound	Fig.,7c
R249	T464	T465	det	The,expression
R2490	T3929	T3927	punct	),7c
R2491	T3930	T3910	punct	.,receives
R2492	T3932	T3933	nsubj	Some,are
R2493	T3934	T3932	prep	of,Some
R2494	T3935	T3936	det	the,bundles
R2495	T3936	T3934	pobj	bundles,of
R2496	T3937	T3938	amod	radial,fiber
R2497	T3938	T3936	compound	fiber,bundles
R2498	T3939	T3933	acomp	myelinated,are
R2499	T3940	T3941	punct	(,Fig.
R25	T217	T216	compound	hair,cells
R250	T465	T467	nsubj	expression,suffices
R2500	T3941	T3933	parataxis	Fig.,are
R2501	T3942	T3941	nummod	7d,Fig.
R2502	T3943	T3941	punct	),Fig.
R2503	T3944	T3933	punct	.,are
R2504	T3946	T3947	advmod	Only,fiber
R2505	T3947	T3950	nsubj	fiber,extends
R2506	T3948	T3947	det	an,fiber
R2507	T3949	T3947	amod	occasional,fiber
R2508	T3951	T3950	prep	beyond,extends
R2509	T3952	T3953	det	the,bundle
R251	T466	T465	amod	limited,expression
R2510	T3953	T3951	pobj	bundle,beyond
R2511	T3954	T3955	amod	inner,spiral
R2512	T3955	T3953	nmod	spiral,bundle
R2513	T3956	T3950	prep	into,extends
R2514	T3957	T3958	det	the,area
R2515	T3958	T3956	pobj	area,into
R2516	T3959	T3958	prep	of,area
R2517	T3960	T3961	det	the,cells
R2518	T3961	T3959	pobj	cells,of
R2519	T3962	T3961	amod	outer,cells
R252	T468	T465	prep	of,expression
R2520	T3963	T3961	compound	hair,cells
R2521	T3964	T3965	punct	(,Fig.
R2522	T3965	T3950	parataxis	Fig.,extends
R2523	T3966	T3965	nummod	7d,Fig.
R2524	T3967	T3965	punct	),Fig.
R2525	T3968	T3950	punct	.,extends
R2526	T3970	T3971	advmod	Even,at
R2527	T3971	T3972	prep	at,are
R2528	T3973	T3974	det	this,stage
R2529	T3974	T3971	pobj	stage,at
R253	T469	T468	pobj	neurotrophins,of
R2530	T3975	T3974	amod	late,stage
R2531	T3976	T3974	prep	in,stage
R2532	T3977	T3976	pobj	maturation,in
R2533	T3978	T3972	expl	there,are
R2534	T3979	T3972	advmod	still,are
R2535	T3980	T3981	amod	numerous,neurons
R2536	T3981	T3972	attr	neurons,are
R2537	T3982	T3981	amod	spiral,neurons
R2538	T3983	T3981	relcl	present,neurons
R2539	T3984	T3983	prep	in,present
R254	T470	T465	prep	in,expression
R2540	T3985	T3986	det	the,apex
R2541	T3986	T3984	pobj	apex,in
R2542	T3987	T3988	punct	(,7d
R2543	T3988	T3972	parataxis	7d,are
R2544	T3989	T3988	nmod	Fig.,7d
R2545	T3990	T3988	nmod	7c,7d
R2546	T3991	T3988	punct	",",7d
R2547	T3992	T3988	punct	),7d
R2548	T3993	T3972	punct	.,are
R2549	T3995	T3996	prep	In,suggest
R255	T471	T472	det	the,cochlea
R2550	T3997	T3995	pobj	summary,In
R2551	T3998	T3996	punct	", ",suggest
R2552	T3999	T4000	det	these,data
R2553	T4000	T3996	nsubj	data,suggest
R2554	T4001	T4000	amod	tracing,data
R2555	T4002	T4003	mark	that,are
R2556	T4003	T3996	ccomp	are,suggest
R2557	T4004	T4005	amod	mature,cells
R2558	T4005	T4003	nsubj	cells,are
R2559	T4006	T4005	compound	hair,cells
R256	T472	T470	pobj	cochlea,in
R2560	T4007	T4003	neg	not,are
R2561	T4008	T4003	acomp	necessary,are
R2562	T4009	T4010	aux	to,direct
R2563	T4010	T4008	xcomp	direct,necessary
R2564	T4011	T4012	compound	fiber,outgrowth
R2565	T4012	T4010	dobj	outgrowth,direct
R2566	T4013	T4010	cc	and,direct
R2567	T4014	T4015	aux	to,maintain
R2568	T4015	T4010	conj	maintain,direct
R2569	T4016	T4017	det	some,fibers
R257	T473	T472	prep	of,cochlea
R2570	T4017	T4015	dobj	fibers,maintain
R2571	T4018	T4019	advmod	at,6
R2572	T4019	T4023	nummod	6,months
R2573	T4020	T4019	advmod	least,6
R2574	T4021	T4019	advmod	up,6
R2575	T4022	T4019	quantmod	to,6
R2576	T4023	T4015	npadvmod	months,maintain
R2577	T4024	T4015	prep	in,maintain
R2578	T4025	T4026	det	the,apex
R2579	T4026	T4024	pobj	apex,in
R258	T474	T475	npadvmod	Brn3c,null
R2580	T4027	T4026	prep	of,apex
R2581	T4028	T4029	det	the,cochlea
R2582	T4029	T4027	pobj	cochlea,of
R2583	T4030	T3996	punct	.,suggest
R2584	T4032	T4033	advmod	Importantly,follow
R2585	T4034	T4033	punct	", ",follow
R2586	T4035	T4036	det	the,loss
R2587	T4036	T4033	nsubj	loss,follow
R2588	T4037	T4038	amod	spatio,temporal
R2589	T4038	T4036	amod	temporal,loss
R259	T475	T476	amod	null,mice
R2590	T4039	T4038	punct	-,temporal
R2591	T4040	T4036	prep	of,loss
R2592	T4041	T4040	pobj	innervation,of
R2593	T4042	T4033	aux	does,follow
R2594	T4043	T4033	neg	not,follow
R2595	T4044	T4045	det	the,pattern
R2596	T4045	T4033	dobj	pattern,follow
R2597	T4046	T4045	prep	of,pattern
R2598	T4047	T4046	pobj	loss,of
R2599	T4048	T4045	acl	known,pattern
R26	T218	T216	punct	", ",cells
R260	T476	T473	pobj	mice,of
R2600	T4049	T4048	prep	from,known
R2601	T4050	T4051	nmod	neurotrophin,mutations
R2602	T4051	T4049	pobj	mutations,from
R2603	T4052	T4050	cc	and,neurotrophin
R2604	T4053	T4054	compound	neurotrophin,receptor
R2605	T4054	T4050	conj	receptor,neurotrophin
R2606	T4055	T4051	amod	null,mutations
R2607	T4056	T4057	mark	as,starts
R2608	T4057	T4033	advcl	starts,follow
R2609	T4058	T4057	nsubj	it,starts
R261	T477	T478	aux	to,support
R2610	T4059	T4057	prep	in,starts
R2611	T4060	T4061	nmod	Brn3c,mice
R2612	T4061	T4059	pobj	mice,in
R2613	T4062	T4061	amod	mutant,mice
R2614	T4063	T4057	prep	after,starts
R2615	T4064	T4063	pobj	birth,after
R2616	T4065	T4033	punct	.,follow
R2617	T4241	T4242	advmod	In,situ
R2618	T4242	T4243	amod	situ,hybridization
R2619	T4243	T4244	nsubj	hybridization,confirms
R262	T478	T467	xcomp	support,suffices
R2620	T4245	T4246	amod	neonatal,expression
R2621	T4246	T4244	dobj	expression,confirms
R2622	T4247	T4246	compound	neurotrophin,expression
R2623	T4249	T4250	nsubj	We,processed
R2624	T4251	T4252	nummod	four,ears
R2625	T4252	T4250	dobj	ears,processed
R2626	T4253	T4252	prep	of,ears
R2627	T4254	T4255	nmod	P0,littermates
R2628	T4255	T4253	pobj	littermates,of
R2629	T4256	T4254	cc	and,P0
R263	T479	T480	amod	many,neurons
R2630	T4257	T4254	conj	P8,P0
R2631	T4258	T4255	nmod	Brn3c,littermates
R2632	T4259	T4255	amod	null,littermates
R2633	T4260	T4259	cc	and,null
R2634	T4261	T4259	conj	control,null
R2635	T4262	T4250	prep	for,processed
R2636	T4263	T4262	pobj	expression,for
R2637	T4264	T4263	prep	of,expression
R2638	T4265	T4264	pobj	BDNF,of
R2639	T4266	T4265	cc	and,BDNF
R264	T480	T478	dobj	neurons,support
R2640	T4267	T4265	conj	NT,BDNF
R2641	T4268	T4267	punct	-,NT
R2642	T4269	T4267	nummod	3,NT
R2643	T4270	T4250	advcl	using,processed
R2644	T4271	T4272	det	the,riboprobes
R2645	T4272	T4270	dobj	riboprobes,using
R2646	T4273	T4274	advmod	previously,described
R2647	T4274	T4272	acl	described,riboprobes
R2648	T4275	T4276	punct	[,7
R2649	T4276	T4250	parataxis	7,processed
R265	T481	T480	amod	sensory,neurons
R2650	T4277	T4276	punct	],7
R2651	T4278	T4250	punct	.,processed
R2652	T4280	T4281	nsubj	We,analyze
R2653	T4282	T4281	aux	did,analyze
R2654	T4283	T4281	neg	not,analyze
R2655	T4284	T4285	compound	neurotrophin,expression
R2656	T4285	T4281	dobj	expression,analyze
R2657	T4286	T4281	prep	in,analyze
R2658	T4287	T4288	amod	6,month
R2659	T4288	T4290	amod	month,old
R266	T482	T478	punct	", ",support
R2660	T4289	T4288	punct	-,month
R2661	T4290	T4291	amod	old,animals
R2662	T4291	T4286	pobj	animals,in
R2663	T4292	T4293	mark	as,downregulated
R2664	T4293	T4281	advcl	downregulated,analyze
R2665	T4294	T4293	nsubjpass	neurotrophins,downregulated
R2666	T4295	T4293	auxpass	are,downregulated
R2667	T4296	T4293	prep	in,downregulated
R2668	T4297	T4296	pobj	neonates,in
R2669	T4298	T4299	punct	[,20
R267	T483	T484	advmod	particularly,in
R2670	T4299	T4293	parataxis	20,downregulated
R2671	T4300	T4299	punct	],20
R2672	T4301	T4293	cc	and,downregulated
R2673	T4302	T4303	det	no,expression
R2674	T4303	T4304	nsubjpass	expression,found
R2675	T4304	T4293	conj	found,downregulated
R2676	T4305	T4304	aux	can,found
R2677	T4306	T4304	auxpass	be,found
R2678	T4307	T4308	advmod	even,in
R2679	T4308	T4304	prep	in,found
R268	T484	T478	prep	in,support
R2680	T4309	T4310	amod	normal,animals
R2681	T4310	T4308	pobj	animals,in
R2682	T4311	T4312	punct	[,4
R2683	T4312	T4304	parataxis	4,found
R2684	T4313	T4312	punct	],4
R2685	T4314	T4281	punct	.,analyze
R2686	T4316	T4317	prep	In,expected
R2687	T4318	T4319	det	the,cristae
R2688	T4319	T4316	pobj	cristae,In
R2689	T4320	T4319	compound	canal,cristae
R269	T485	T486	det	the,cochlea
R2690	T4321	T4317	nsubj	we,expected
R2691	T4322	T4317	punct	", ",expected
R2692	T4323	T4317	cc	and,expected
R2693	T4324	T4317	conj	found,expected
R2694	T4325	T4324	punct	", ",found
R2695	T4326	T4327	advmod	only,signal
R2696	T4327	T4324	conj	signal,found
R2697	T4328	T4327	det	a,signal
R2698	T4329	T4327	compound	BDNF,signal
R2699	T4330	T4317	punct	.,expected
R27	T219	T216	amod	identifiable,cells
R270	T486	T484	pobj	cochlea,in
R2700	T4332	T4333	det	This,signal
R2701	T4333	T4334	nsubj	signal,was
R2702	T4335	T4336	advmod	very,strong
R2703	T4336	T4334	acomp	strong,was
R2704	T4337	T4334	prep	over,was
R2705	T4338	T4339	compound	hair,cells
R2706	T4339	T4337	pobj	cells,over
R2707	T4340	T4339	prep	of,cells
R2708	T4341	T4342	det	the,animals
R2709	T4342	T4340	pobj	animals,of
R271	T487	T478	punct	", ",support
R2710	T4343	T4342	compound	P0,animals
R2711	T4344	T4342	compound	control,animals
R2712	T4345	T4346	punct	(,8b
R2713	T4346	T4334	parataxis	8b,was
R2714	T4347	T4346	compound	Fig.,8b
R2715	T4348	T4346	punct	),8b
R2716	T4349	T4334	punct	.,was
R2717	T4351	T4352	prep	In,detected
R2718	T4353	T4351	pobj	contrast,In
R2719	T4354	T4352	punct	", ",detected
R272	T488	T478	prep	until,support
R2720	T4355	T4356	advmod	only,signal
R2721	T4356	T4352	nsubjpass	signal,detected
R2722	T4357	T4356	det	a,signal
R2723	T4358	T4356	amod	faint,signal
R2724	T4359	T4352	auxpass	was,detected
R2725	T4360	T4352	prep	in,detected
R2726	T4361	T4362	det	the,mutant
R2727	T4362	T4360	pobj	mutant,in
R2728	T4363	T4362	nmod	Brn3c,mutant
R2729	T4364	T4362	amod	null,mutant
R273	T489	T488	pobj	birth,until
R2730	T4365	T4366	punct	(,8a
R2731	T4366	T4352	parataxis	8a,detected
R2732	T4367	T4366	compound	Fig.,8a
R2733	T4368	T4366	punct	),8a
R2734	T4369	T4352	cc	and,detected
R2735	T4370	T4371	det	the,grains
R2736	T4371	T4374	nsubjpass	grains,located
R2737	T4372	T4371	amod	few,grains
R2738	T4373	T4371	amod	silver,grains
R2739	T4374	T4352	conj	located,detected
R274	T490	T467	punct	.,suffices
R2740	T4375	T4374	auxpass	were,located
R2741	T4376	T4374	advmod	predominantly,located
R2742	T4377	T4374	prep	over,located
R2743	T4378	T4379	det	the,area
R2744	T4379	T4377	pobj	area,over
R2745	T4380	T4379	prep	of,area
R2746	T4381	T4382	det	the,cells
R2747	T4382	T4380	pobj	cells,of
R2748	T4383	T4382	amod	immature,cells
R2749	T4384	T4382	compound	hair,cells
R275	T492	T493	det	The,nature
R2750	T4385	T4352	punct	.,detected
R2751	T4387	T4388	det	The,signal
R2752	T4388	T4390	nsubjpass	signal,centered
R2753	T4389	T4388	compound	BDNF,signal
R2754	T4391	T4388	prep	in,signal
R2755	T4392	T4393	det	the,utricle
R2756	T4393	T4391	pobj	utricle,in
R2757	T4394	T4390	auxpass	was,centered
R2758	T4395	T4390	advmod	clearly,centered
R2759	T4396	T4390	prep	on,centered
R276	T493	T495	nsubj	nature,remains
R2760	T4397	T4398	det	the,cells
R2761	T4398	T4396	pobj	cells,on
R2762	T4399	T4398	compound	hair,cells
R2763	T4400	T4390	prep	in,centered
R2764	T4401	T4402	det	the,animal
R2765	T4402	T4400	pobj	animal,in
R2766	T4403	T4402	compound	control,animal
R2767	T4404	T4390	cc	but,centered
R2768	T4405	T4406	det	some,aggregation
R2769	T4406	T4407	nsubj	aggregation,appeared
R277	T494	T493	amod	molecular,nature
R2770	T4407	T4390	conj	appeared,centered
R2771	T4408	T4406	prep	of,aggregation
R2772	T4409	T4410	compound	silver,grains
R2773	T4410	T4408	pobj	grains,of
R2774	T4411	T4407	advmod	also,appeared
R2775	T4412	T4407	prep	in,appeared
R2776	T4413	T4414	det	the,mutants
R2777	T4414	T4412	pobj	mutants,in
R2778	T4415	T4414	nmod	Brn3c,mutants
R2779	T4416	T4414	amod	null,mutants
R278	T496	T493	prep	of,nature
R2780	T4417	T4418	punct	(,shown
R2781	T4418	T4407	parataxis	shown,appeared
R2782	T4419	T4418	nsubj	data,shown
R2783	T4420	T4418	neg	not,shown
R2784	T4421	T4418	punct	),shown
R2785	T4422	T4407	punct	.,appeared
R2786	T4425	T4426	prep	In,compared
R2787	T4427	T4428	det	the,saccule
R2788	T4428	T4425	pobj	saccule,In
R2789	T4429	T4426	punct	", ",compared
R279	T497	T498	det	the,survival
R2790	T4430	T4426	nsubj	we,compared
R2791	T4431	T4426	advmod	directly,compared
R2792	T4432	T4433	det	the,signal
R2793	T4433	T4426	dobj	signal,compared
R2794	T4434	T4433	nmod	BDNF,signal
R2795	T4435	T4436	punct	(,8d
R2796	T4436	T4434	parataxis	8d,BDNF
R2797	T4437	T4436	nmod	Fig.,8d
R2798	T4438	T4436	nmod	8c,8d
R2799	T4439	T4436	punct	",",8d
R28	T220	T221	advmod	only,by
R280	T498	T496	pobj	survival,of
R2800	T4440	T4436	punct	),8d
R2801	T4441	T4434	cc	and,BDNF
R2802	T4442	T4434	conj	NT,BDNF
R2803	T4443	T4442	punct	-,NT
R2804	T4444	T4442	nummod	3,NT
R2805	T4445	T4446	punct	(,8f
R2806	T4446	T4433	parataxis	8f,signal
R2807	T4447	T4446	nmod	Fig.,8f
R2808	T4448	T4446	nmod	8e,8f
R2809	T4449	T4446	punct	",",8f
R281	T499	T500	amod	long,term
R2810	T4450	T4446	punct	),8f
R2811	T4451	T4433	prep	of,signal
R2812	T4452	T4453	det	the,mutant
R2813	T4453	T4451	pobj	mutant,of
R2814	T4454	T4455	npadvmod	Brn3c,null
R2815	T4455	T4453	amod	null,mutant
R2816	T4456	T4457	punct	(,8e
R2817	T4457	T4453	parataxis	8e,mutant
R2818	T4458	T4457	nmod	Fig.,8e
R2819	T4459	T4457	nmod	8c,8e
R282	T500	T498	compound	term,survival
R2820	T4460	T4457	punct	",",8e
R2821	T4461	T4457	punct	),8e
R2822	T4462	T4453	cc	and,mutant
R2823	T4463	T4464	compound	control,littermates
R2824	T4464	T4453	conj	littermates,mutant
R2825	T4465	T4466	punct	(,8f
R2826	T4466	T4464	parataxis	8f,littermates
R2827	T4467	T4466	nmod	Fig.,8f
R2828	T4468	T4466	nummod	8d,8f
R2829	T4469	T4466	punct	",",8f
R283	T501	T498	prep	of,survival
R2830	T4470	T4466	punct	),8f
R2831	T4471	T4426	punct	.,compared
R2832	T4473	T4474	det	A,signal
R2833	T4474	T4477	nsubjpass	signal,found
R2834	T4475	T4474	amod	strong,signal
R2835	T4476	T4474	compound	BDNF,signal
R2836	T4478	T4477	auxpass	was,found
R2837	T4479	T4477	prep	over,found
R2838	T4480	T4481	det	the,cells
R2839	T4481	T4479	pobj	cells,over
R284	T502	T503	amod	apical,spiral
R2840	T4482	T4481	compound	hair,cells
R2841	T4483	T4481	prep	of,cells
R2842	T4484	T4485	compound	control,animals
R2843	T4485	T4483	pobj	animals,of
R2844	T4486	T4477	cc	and,found
R2845	T4487	T4488	det	an,cell
R2846	T4488	T4492	nsubj	cell,showed
R2847	T4489	T4488	amod	occasional,cell
R2848	T4490	T4488	amod	immature,cell
R2849	T4491	T4488	compound	hair,cell
R285	T503	T504	nmod	spiral,neurons
R2850	T4492	T4477	conj	showed,found
R2851	T4493	T4492	advmod	also,showed
R2852	T4494	T4495	det	a,signal
R2853	T4495	T4492	dobj	signal,showed
R2854	T4496	T4495	compound	BDNF,signal
R2855	T4497	T4492	prep	in,showed
R2856	T4498	T4499	det	the,mutants
R2857	T4499	T4497	pobj	mutants,in
R2858	T4500	T4499	nmod	Brn3c,mutants
R2859	T4501	T4499	amod	null,mutants
R286	T504	T501	pobj	neurons,of
R2860	T4502	T4492	punct	.,showed
R2861	T4504	T4505	det	The,signal
R2862	T4505	T4509	nsubj	signal,was
R2863	T4506	T4505	nmod	NT,signal
R2864	T4507	T4506	punct	-,NT
R2865	T4508	T4506	nummod	3,NT
R2866	T4510	T4511	advmod	more,diffuse
R2867	T4511	T4509	acomp	diffuse,was
R2868	T4512	T4509	prep	in,was
R2869	T4513	T4514	preconj	both,control
R287	T505	T495	oprd	unclear,remains
R2870	T4514	T4512	pobj	control,in
R2871	T4515	T4514	det	the,control
R2872	T4516	T4514	cc	and,control
R2873	T4517	T4518	det	the,null
R2874	T4518	T4520	nmod	null,littermates
R2875	T4519	T4518	npadvmod	Brn3c,null
R2876	T4520	T4514	conj	littermates,control
R2877	T4521	T4509	cc	but,was
R2878	T4522	T4509	conj	showed,was
R2879	T4523	T4524	det	some,signal
R288	T506	T495	punct	.,remains
R2880	T4524	T4522	dobj	signal,showed
R2881	T4525	T4526	advmod	slightly,above
R2882	T4526	T4524	amod	above,signal
R2883	T4527	T4524	compound	background,signal
R2884	T4528	T4522	prep	in,showed
R2885	T4529	T4530	det	the,area
R2886	T4530	T4528	pobj	area,in
R2887	T4531	T4530	prep	of,area
R2888	T4532	T4533	det	the,epithelium
R2889	T4533	T4531	pobj	epithelium,of
R289	T187	T188	npadvmod	Brn3c,null
R2890	T4534	T4533	amod	sensory,epithelium
R2891	T4535	T4536	advmod	even,in
R2892	T4536	T4522	prep	in,showed
R2893	T4537	T4538	det	the,mutant
R2894	T4538	T4536	pobj	mutant,in
R2895	T4539	T4538	nmod	Brn3c,mutant
R2896	T4540	T4538	amod	null,mutant
R2897	T4541	T4509	punct	.,was
R2898	T4543	T4544	prep	In,was
R2899	T4545	T4546	det	the,cochlea
R29	T221	T219	prep	by,identifiable
R2900	T4546	T4543	pobj	cochlea,In
R2901	T4547	T4544	punct	", ",was
R2902	T4548	T4549	det	the,signal
R2903	T4549	T4544	nsubj	signal,was
R2904	T4550	T4549	compound	BDNF,signal
R2905	T4551	T4552	advmod	very,weak
R2906	T4552	T4544	acomp	weak,was
R2907	T4553	T4544	prep	in,was
R2908	T4554	T4555	det	the,base
R2909	T4555	T4553	pobj	base,in
R2910	T4556	T4544	prep	in,was
R2911	T4557	T4558	preconj	both,control
R2912	T4558	T4556	pobj	control,in
R2913	T4559	T4558	det	the,control
R2914	T4560	T4561	punct	(,9b
R2915	T4561	T4558	parataxis	9b,control
R2916	T4562	T4561	compound	Fig.,9b
R2917	T4563	T4561	punct	),9b
R2918	T4564	T4558	cc	and,control
R2919	T4565	T4566	det	the,Brn3c
R2920	T4566	T4567	nmod	Brn3c,littermates
R2921	T4567	T4558	conj	littermates,control
R2922	T4568	T4566	amod	null,Brn3c
R2923	T4569	T4570	punct	(,9a
R2924	T4570	T4567	parataxis	9a,littermates
R2925	T4571	T4570	compound	Fig.,9a
R2926	T4572	T4570	punct	),9a
R2927	T4573	T4544	punct	.,was
R2928	T4575	T4576	advmod	However,was
R2929	T4577	T4576	punct	", ",was
R2930	T4578	T4576	expl	there,was
R2931	T4579	T4580	det	a,signal
R2932	T4580	T4576	attr	signal,was
R2933	T4581	T4582	advmod	surprisingly,strong
R2934	T4582	T4580	amod	strong,signal
R2935	T4583	T4580	nmod	NT,signal
R2936	T4584	T4583	punct	-,NT
R2937	T4585	T4583	nummod	3,NT
R2938	T4586	T4580	prep	over,signal
R2939	T4587	T4588	det	the,organ
R2940	T4588	T4586	pobj	organ,over
R2941	T4589	T4588	prep	of,organ
R2942	T4590	T4589	pobj	Corti,of
R2943	T4591	T4580	prep	in,signal
R2944	T4592	T4593	det	the,apex
R2945	T4593	T4591	pobj	apex,in
R2946	T4594	T4593	prep	of,apex
R2947	T4595	T4596	nmod	Brn3c,littermates
R2948	T4596	T4594	pobj	littermates,of
R2949	T4597	T4596	amod	null,littermates
R2950	T4598	T4599	punct	(,9c
R2951	T4599	T4596	parataxis	9c,littermates
R2952	T4600	T4599	compound	Fig.,9c
R2953	T4601	T4599	punct	),9c
R2954	T4602	T4603	dep	that,matched
R2955	T4603	T4580	relcl	matched,signal
R2956	T4604	T4603	advmod	closely,matched
R2957	T4605	T4606	det	the,signal
R2958	T4606	T4603	dobj	signal,matched
R2959	T4607	T4606	acl	found,signal
R2960	T4608	T4607	prep	in,found
R2961	T4609	T4610	det	the,littermates
R2962	T4610	T4608	pobj	littermates,in
R2963	T4611	T4610	compound	control,littermates
R2964	T4612	T4613	punct	(,Fig.
R2965	T4613	T4603	parataxis	Fig.,matched
R2966	T4614	T4613	nummod	9d,Fig.
R2967	T4615	T4613	punct	),Fig.
R2968	T4616	T4576	punct	.,was
R2969	T4618	T4619	det	The,signal
R2970	T4619	T4623	nsubj	signal,persisted
R2971	T4620	T4619	nmod	NT,signal
R2972	T4621	T4620	punct	-,NT
R2973	T4622	T4620	nummod	3,NT
R2974	T4624	T4619	prep	in,signal
R2975	T4625	T4626	det	the,area
R2976	T4626	T4624	pobj	area,in
R2977	T4627	T4626	prep	of,area
R2978	T4628	T4629	det	the,cochlea
R2979	T4629	T4627	pobj	cochlea,of
R2980	T4630	T4631	dep	that,corresponds
R2981	T4631	T4619	relcl	corresponds,signal
R2982	T4632	T4631	prep	to,corresponds
R2983	T4633	T4634	det	the,IHC
R2984	T4634	T4632	pobj	IHC,to
R2985	T4635	T4634	case	's,IHC
R2986	T4636	T4637	advmod	at,least
R2987	T4637	T4638	advmod	least,until
R2988	T4638	T4623	prep	until,persisted
R2989	T4639	T4638	pobj	P8,until
R2990	T4640	T4623	prep	in,persisted
R2991	T4641	T4642	det	the,apex
R2992	T4642	T4640	pobj	apex,in
R2993	T4643	T4642	prep	of,apex
R2994	T4644	T4645	nmod	Brn3c,mice
R2995	T4645	T4643	pobj	mice,of
R2996	T4646	T4645	amod	null,mice
R2997	T4647	T4648	punct	(,9f
R2998	T4648	T4623	parataxis	9f,persisted
R2999	T4649	T4648	nmod	Fig.,9f
R3	T188	T190	amod	null,mice
R30	T222	T223	amod	certain,markers
R300	T820	T821	nsubj	Brn3c,is
R3000	T4650	T4648	nummod	9e,9f
R3001	T4651	T4648	punct	",",9f
R3002	T4652	T4648	punct	),9f
R3003	T4653	T4623	punct	.,persisted
R3004	T4693	T4694	nsubj	We,explore
R3005	T4695	T4694	aux	will,explore
R3006	T4696	T4697	nummod	five,points
R3007	T4697	T4694	dative	points,explore
R3008	T4698	T4694	prep	in,explore
R3009	T4699	T4700	det	this,discussion
R301	T822	T823	det	a,factor
R3010	T4700	T4698	pobj	discussion,in
R3011	T4701	T4694	punct	: ,explore
R3012	T4702	T4703	advmod	How,relates
R3013	T4703	T4694	dobj	relates,explore
R3014	T4704	T4705	det	the,expression
R3015	T4705	T4703	nsubj	expression,relates
R3016	T4706	T4705	amod	limited,expression
R3017	T4707	T4705	prep	of,expression
R3018	T4708	T4707	pobj	neurotrophins,of
R3019	T4709	T4703	prep	to,relates
R302	T823	T821	attr	factor,is
R3020	T4710	T4711	det	the,survival
R3021	T4711	T4709	pobj	survival,to
R3022	T4712	T4711	amod	apparent,survival
R3023	T4713	T4711	prep	of,survival
R3024	T4714	T4715	amod	primary,neurons
R3025	T4715	T4713	pobj	neurons,of
R3026	T4716	T4711	prep	until,survival
R3027	T4717	T4716	pobj	P8,until
R3028	T4718	T4703	punct	;,relates
R3029	T4719	T4720	advmod	how,be
R303	T824	T825	compound	POU,domain
R3030	T4720	T4703	conj	be,relates
R3031	T4721	T4722	det	the,absence
R3032	T4722	T4720	nsubj	absence,be
R3033	T4723	T4722	amod	known,absence
R3034	T4724	T4722	prep	of,absence
R3035	T4725	T4726	amod	apical,cells
R3036	T4726	T4724	pobj	cells,of
R3037	T4727	T4726	compound	hair,cells
R3038	T4728	T4724	cc	and,of
R3039	T4729	T4724	conj	of,of
R304	T825	T823	compound	domain,factor
R3040	T4730	T4731	amod	classical,neurotrophins
R3041	T4731	T4729	pobj	neurotrophins,of
R3042	T4732	T4720	aux	can,be
R3043	T4733	T4720	acomp	related,be
R3044	T4734	T4733	prep	to,related
R3045	T4735	T4736	det	the,presence
R3046	T4736	T4734	pobj	presence,to
R3047	T4737	T4736	prep	of,presence
R3048	T4738	T4739	amod	large,numbers
R3049	T4739	T4737	pobj	numbers,of
R305	T826	T827	dep	that,is
R3050	T4740	T4739	prep	of,numbers
R3051	T4741	T4742	amod	apical,turn
R3052	T4742	T4743	nmod	turn,neurons
R3053	T4743	T4740	pobj	neurons,of
R3054	T4744	T4743	amod	spiral,neurons
R3055	T4745	T4720	punct	;,be
R3056	T4746	T4747	advmod	how,affects
R3057	T4747	T4720	conj	affects,be
R3058	T4748	T4747	nsubj	absence,affects
R3059	T4749	T4748	prep	of,absence
R306	T827	T823	relcl	is,factor
R3060	T4750	T4751	amod	differentiated,cells
R3061	T4751	T4749	pobj	cells,of
R3062	T4752	T4751	compound	hair,cells
R3063	T4753	T4754	amod	afferent,targeting
R3064	T4754	T4747	dobj	targeting,affects
R3065	T4755	T4753	cc	and,afferent
R3066	T4756	T4753	conj	efferent,afferent
R3067	T4757	T4747	punct	;,affects
R3068	T4758	T4747	cc	and,affects
R3069	T4759	T4760	advmod	how,relate
R307	T828	T827	acomp	crucial,is
R3070	T4760	T4747	conj	relate,affects
R3071	T4761	T4762	det	these,data
R3072	T4762	T4760	nsubj	data,relate
R3073	T4763	T4760	advmod	possibly,relate
R3074	T4764	T4760	prep	to,relate
R3075	T4765	T4766	amod	other,animals
R3076	T4766	T4764	pobj	animals,to
R3077	T4767	T4766	amod	mutant,animals
R3078	T4768	T4764	cc	and,to
R3079	T4769	T4764	conj	to,to
R308	T829	T828	prep	for,crucial
R3080	T4770	T4769	pobj	children,to
R3081	T4771	T4770	acl	born,children
R3082	T4772	T4771	prep	with,born
R3083	T4773	T4774	amod	profound,loss
R3084	T4774	T4772	pobj	loss,with
R3085	T4775	T4774	compound	hearing,loss
R3086	T4776	T4694	punct	.,explore
R309	T830	T831	amod	inner,ear
R3095	T5075	T5076	amod	Immature,cells
R3096	T5076	T5078	nsubj	cells,rescue
R3097	T5077	T5076	compound	hair,cells
R3098	T5079	T5076	cc	and,cells
R3099	T5080	T5081	amod	limited,expression
R31	T223	T221	pobj	markers,by
R310	T831	T832	nmod	ear,development
R3100	T5081	T5076	conj	expression,cells
R3101	T5082	T5081	prep	of,expression
R3102	T5083	T5082	pobj	neurotrophins,of
R3103	T5084	T5085	amod	afferent,projection
R3104	T5085	T5078	dobj	projection,rescue
R3105	T5086	T5078	prep	until,rescue
R3106	T5087	T5086	pobj	P8,until
R3107	T5089	T5090	det	The,neurotrophins
R3108	T5090	T5091	nsubjpass	neurotrophins,implicated
R3109	T5092	T5091	aux	have,implicated
R311	T832	T829	pobj	development,for
R3110	T5093	T5091	advmod	long,implicated
R3111	T5094	T5091	auxpass	been,implicated
R3112	T5095	T5091	prep	as,implicated
R3113	T5096	T5097	det	the,mediators
R3114	T5097	T5095	pobj	mediators,as
R3115	T5098	T5097	prep	for,mediators
R3116	T5099	T5100	npadvmod	target,mediated
R3117	T5100	T5101	amod	mediated,death
R3118	T5101	T5098	pobj	death,for
R3119	T5102	T5101	compound	cell,death
R312	T833	T834	compound	hair,cell
R3120	T5103	T5091	punct	.,implicated
R3121	T5105	T5106	prep	In,implies
R3122	T5107	T5105	pobj	essence,In
R3123	T5108	T5106	punct	", ",implies
R3124	T5109	T5110	det	this,theory
R3125	T5110	T5106	nsubj	theory,implies
R3126	T5111	T5110	prep	of,theory
R3127	T5112	T5111	pobj	regulation,of
R3128	T5113	T5112	prep	of,regulation
R3129	T5114	T5115	amod	neuronal,connections
R313	T834	T832	compound	cell,development
R3130	T5115	T5113	pobj	connections,of
R3131	T5116	T5112	prep	via,regulation
R3132	T5117	T5118	amod	neurotrophic,support
R3133	T5118	T5116	pobj	support,via
R3134	T5119	T5120	mark	that,released
R3135	T5120	T5106	ccomp	released,implies
R3136	T5121	T5122	advmod	only,quantities
R3137	T5122	T5120	nsubjpass	quantities,released
R3138	T5123	T5122	amod	limited,quantities
R3139	T5124	T5122	prep	of,quantities
R314	T835	T821	punct	.,is
R3140	T5125	T5124	pobj	neurotrophins,of
R3141	T5126	T5120	auxpass	are,released
R3142	T5127	T5120	agent	by,released
R3143	T5128	T5129	det	the,tissue
R3144	T5129	T5127	pobj	tissue,by
R3145	T5130	T5129	compound	target,tissue
R3146	T5131	T5132	aux	to,support
R3147	T5132	T5120	advcl	support,released
R3148	T5133	T5134	advmod	only,neurons
R3149	T5134	T5132	dobj	neurons,support
R315	T837	T838	amod	Targeted,mutants
R3150	T5135	T5136	advmod	properly,connected
R3151	T5136	T5134	amod	connected,neurons
R3152	T5137	T5134	amod	sensory,neurons
R3153	T5138	T5132	prep	by,support
R3154	T5139	T5138	pcomp	providing,by
R3155	T5140	T5141	advmod	only,these
R3156	T5141	T5139	dobj	these,providing
R3157	T5142	T5139	prep	with,providing
R3158	T5143	T5144	det	a,amount
R3159	T5144	T5142	pobj	amount,with
R316	T838	T841	nsubj	mutants,have
R3160	T5145	T5144	amod	critical,amount
R3161	T5146	T5144	prep	of,amount
R3162	T5147	T5146	pobj	neurotrophins,of
R3163	T5148	T5149	punct	[,21
R3164	T5149	T5106	parataxis	21,implies
R3165	T5150	T5149	punct	],21
R3166	T5151	T5106	punct	.,implies
R3167	T5153	T5154	compound	Past,experiments
R3168	T5154	T5155	nsubj	experiments,tested
R3169	T5156	T5154	punct	", ",experiments
R317	T839	T838	amod	null,mutants
R3170	T5157	T5158	dep	which,eliminated
R3171	T5158	T5154	relcl	eliminated,experiments
R3172	T5159	T5160	nummod	one,neurotrophins
R3173	T5160	T5158	dobj	neurotrophins,eliminated
R3174	T5161	T5159	cc	or,one
R3175	T5162	T5159	conj	more,one
R3176	T5163	T5158	advmod	entirely,eliminated
R3177	T5164	T5155	punct	", ",tested
R3178	T5165	T5166	advmod	only,partially
R3179	T5166	T5155	advmod	partially,tested
R318	T840	T838	compound	Brn3c,mutants
R3180	T5167	T5168	det	the,assumption
R3181	T5168	T5155	dobj	assumption,tested
R3182	T5169	T5168	amod	basic,assumption
R3183	T5170	T5168	prep	of,assumption
R3184	T5171	T5172	det	this,theory
R3185	T5172	T5170	pobj	theory,of
R3186	T5173	T5174	advmod	in,vivo
R3187	T5174	T5155	advmod	vivo,tested
R3188	T5175	T5155	punct	.,tested
R3189	T5177	T5178	prep	For,is
R319	T842	T843	det	no,cells
R3190	T5179	T5177	pobj	example,For
R3191	T5180	T5178	punct	", ",is
R3192	T5181	T5178	prep	in,is
R3193	T5182	T5183	nmod	BDNF,animals
R3194	T5183	T5181	pobj	animals,in
R3195	T5184	T5183	amod	heterozygotic,animals
R3196	T5185	T5178	expl	there,is
R3197	T5186	T5187	det	a,decrease
R3198	T5187	T5178	attr	decrease,is
R3199	T5188	T5187	amod	small,decrease
R32	T224	T223	amod	molecular,markers
R320	T843	T841	dobj	cells,have
R3200	T5189	T5187	prep	in,decrease
R3201	T5190	T5191	det	the,number
R3202	T5191	T5189	pobj	number,in
R3203	T5192	T5191	prep	of,number
R3204	T5193	T5194	amod	sensory,neurons
R3205	T5194	T5192	pobj	neurons,of
R3206	T5195	T5194	prep	in,neurons
R3207	T5196	T5197	det	the,ear
R3208	T5197	T5195	pobj	ear,in
R3209	T5198	T5199	punct	[,13
R321	T844	T843	amod	mature,cells
R3210	T5199	T5187	parataxis	13,decrease
R3211	T5200	T5199	punct	],13
R3212	T5201	T5187	cc	but,decrease
R3213	T5202	T5203	det	no,change
R3214	T5203	T5187	conj	change,decrease
R3215	T5204	T5203	prep	in,change
R3216	T5205	T5206	det	the,pattern
R3217	T5206	T5204	pobj	pattern,in
R3218	T5207	T5206	amod	overall,pattern
R3219	T5208	T5206	prep	of,pattern
R322	T845	T843	compound	hair,cells
R3220	T5209	T5208	pobj	innervation,of
R3221	T5210	T5178	punct	.,is
R3222	T5212	T5213	advmod	Moreover,eliminate
R3223	T5214	T5213	punct	", ",eliminate
R3224	T5215	T5213	nsubj	all,eliminate
R3225	T5216	T5215	prep	of,all
R3226	T5217	T5218	det	the,mutants
R3227	T5218	T5216	pobj	mutants,of
R3228	T5219	T5220	nmod	neurotrophin,neurotrophin
R3229	T5220	T5222	nmod	neurotrophin,receptor
R323	T846	T847	punct	[,2
R3230	T5221	T5220	punct	/,neurotrophin
R3231	T5222	T5218	nmod	receptor,mutants
R3232	T5223	T5218	amod	null,mutants
R3233	T5224	T5218	acl	studied,mutants
R3234	T5225	T5224	prep	to,studied
R3235	T5226	T5225	pobj	date,to
R3236	T5227	T5213	dobj	expression,eliminate
R3237	T5228	T5213	prep	in,eliminate
R3238	T5229	T5230	preconj	both,target
R3239	T5230	T5228	pobj	target,in
R324	T847	T841	parataxis	2,have
R3240	T5231	T5230	det	the,target
R3241	T5232	T5230	amod	peripheral,target
R3242	T5233	T5230	cc	and,target
R3243	T5234	T5235	det	the,brain
R3244	T5235	T5230	conj	brain,target
R3245	T5236	T5213	advmod	simultaneously,eliminate
R3246	T5237	T5213	cc	and,eliminate
R3247	T5238	T5213	conj	achieve,eliminate
R3248	T5239	T5240	poss	their,effects
R3249	T5240	T5238	dobj	effects,achieve
R325	T848	T847	nummod	1,2
R3250	T5241	T5238	prep	in,achieve
R3251	T5242	T5243	amod	late,embryos
R3252	T5243	T5241	pobj	embryos,in
R3253	T5244	T5213	punct	.,eliminate
R3254	T5246	T5247	prep	In,expressed
R3255	T5248	T5246	pobj	contrast,In
R3256	T5249	T5247	punct	", ",expressed
R3257	T5250	T5247	nsubjpass	Brn3c,expressed
R3258	T5251	T5247	auxpass	is,expressed
R3259	T5252	T5247	advmod	barely,expressed
R326	T849	T847	punct	",",2
R3260	T5253	T5247	prep	during,expressed
R3261	T5254	T5253	pobj	embryogenesis,during
R3262	T5255	T5247	prep	in,expressed
R3263	T5256	T5257	det	the,CNS
R3264	T5257	T5255	pobj	CNS,in
R3265	T5258	T5259	punct	[,22
R3266	T5259	T5247	parataxis	22,expressed
R3267	T5260	T5259	punct	],22
R3268	T5261	T5262	advmod	thus,arguing
R3269	T5262	T5247	advcl	arguing,expressed
R327	T850	T847	punct	],2
R3270	T5263	T5264	mark	that,depends
R3271	T5264	T5262	ccomp	depends,arguing
R3272	T5265	T5266	det	the,survival
R3273	T5266	T5264	nsubj	survival,depends
R3274	T5267	T5266	prep	of,survival
R3275	T5268	T5269	amod	ear,neurons
R3276	T5269	T5267	pobj	neurons,of
R3277	T5270	T5269	amod	primary,neurons
R3278	T5271	T5264	advmod	crucially,depends
R3279	T5272	T5264	prep	on,depends
R328	T851	T841	punct	.,have
R3280	T5273	T5274	det	the,periphery
R3281	T5274	T5272	pobj	periphery,on
R3282	T5275	T5247	punct	.,expressed
R3283	T5277	T5278	nsubj	We,suggest
R3284	T5279	T5280	mark	that,leads
R3285	T5280	T5278	ccomp	leads,suggest
R3286	T5281	T5282	amod	limited,expression
R3287	T5282	T5280	nsubj	expression,leads
R3288	T5283	T5282	prep	of,expression
R3289	T5284	T5283	pobj	neurotrophins,of
R329	T853	T854	compound	Close,examination
R3290	T5285	T5282	prep	in,expression
R3291	T5286	T5287	det	the,target
R3292	T5287	T5285	pobj	target,in
R3293	T5288	T5287	amod	immature,target
R3294	T5289	T5280	prep	to,leads
R3295	T5290	T5289	pobj	retention,to
R3296	T5291	T5290	prep	of,retention
R3297	T5292	T5293	amod	primary,neurons
R3298	T5293	T5291	pobj	neurons,of
R3299	T5294	T5293	cc	and,neurons
R33	T225	T210	punct	", ",develop
R330	T854	T855	nsubj	examination,revealed
R3300	T5295	T5296	poss	their,fibers
R3301	T5296	T5293	conj	fibers,neurons
R3302	T5297	T5296	amod	afferent,fibers
R3303	T5298	T5290	prep	in,retention
R3304	T5299	T5300	amod	newborn,mice
R3305	T5300	T5298	pobj	mice,in
R3306	T5301	T5299	cc	and,newborn
R3307	T5302	T5303	amod	early,postnatal
R3308	T5303	T5299	conj	postnatal,newborn
R3309	T5304	T5300	nmod	Brn3c,mice
R331	T856	T855	aux	has,revealed
R3310	T5305	T5300	amod	null,mice
R3311	T5306	T5278	punct	.,suggest
R3312	T5308	T5309	prep	In,show
R3313	T5310	T5308	pobj	agreement,In
R3314	T5311	T5310	prep	with,agreement
R3315	T5312	T5313	det	this,suggestion
R3316	T5313	T5311	pobj	suggestion,with
R3317	T5314	T5309	punct	", ",show
R3318	T5315	T5316	poss	our,data
R3319	T5316	T5309	nsubj	data,show
R332	T857	T858	mark	that,form
R3320	T5317	T5318	advmod	in,situ
R3321	T5318	T5316	amod	situ,data
R3322	T5319	T5320	det	a,reduction
R3323	T5320	T5309	dobj	reduction,show
R3324	T5321	T5320	amod	severe,reduction
R3325	T5322	T5320	prep	in,reduction
R3326	T5323	T5322	pobj	expression,in
R3327	T5324	T5323	prep	of,expression
R3328	T5325	T5324	pobj	BDNF,of
R3329	T5326	T5327	punct	(,9
R333	T858	T855	ccomp	form,revealed
R3330	T5327	T5309	parataxis	9,show
R3331	T5328	T5327	nmod	Figs.,9
R3332	T5329	T5327	nummod	8,9
R3333	T5330	T5327	punct	", ",9
R3334	T5331	T5327	punct	),9
R3335	T5332	T5309	punct	.,show
R3336	T5334	T5335	prep	Despite,expressed
R3337	T5336	T5337	det	this,reduction
R3338	T5337	T5334	pobj	reduction,Despite
R3339	T5338	T5335	punct	", ",expressed
R334	T859	T860	det	some,cells
R3340	T5339	T5340	det	some,levels
R3341	T5340	T5335	nsubjpass	levels,expressed
R3342	T5341	T5340	punct	", ",levels
R3343	T5342	T5343	advmod	apparently,significant
R3344	T5343	T5340	amod	significant,levels
R3345	T5344	T5343	advmod	biologically,significant
R3346	T5345	T5340	amod	low,levels
R3347	T5346	T5340	prep	of,levels
R3348	T5347	T5346	pobj	neurotrophins,of
R3349	T5348	T5335	auxpass	are,expressed
R335	T860	T858	nsubj	cells,form
R3350	T5349	T5335	advmod	apparently,expressed
R3351	T5350	T5335	prep	in,expressed
R3352	T5351	T5352	det	all,epithelia
R3353	T5352	T5350	pobj	epithelia,in
R3354	T5353	T5352	amod	sensory,epithelia
R3355	T5354	T5335	prep	in,expressed
R3356	T5355	T5356	amod	embryonic,mutants
R3357	T5356	T5354	pobj	mutants,in
R3358	T5357	T5356	nmod	Brn3c,mutants
R3359	T5358	T5356	amod	null,mutants
R336	T861	T860	punct	',cells
R3360	T5359	T5335	punct	.,expressed
R3361	T5361	T5362	nsubj	It,appears
R3362	T5363	T5364	mark	that,sustain
R3363	T5364	T5362	ccomp	sustain,appears
R3364	T5365	T5366	advmod	even,levels
R3365	T5366	T5364	nsubj	levels,sustain
R3366	T5367	T5366	det	these,levels
R3367	T5368	T5366	amod	low,levels
R3368	T5369	T5366	prep	of,levels
R3369	T5370	T5369	pobj	neurotrophins,of
R337	T862	T860	amod	immature,cells
R3370	T5371	T5366	prep	in,levels
R3371	T5372	T5373	det	the,epithelia
R3372	T5373	T5371	pobj	epithelia,in
R3373	T5374	T5373	amod	vestibular,epithelia
R3374	T5375	T5373	amod	sensory,epithelia
R3375	T5376	T5364	aux	can,sustain
R3376	T5377	T5378	amod	normal,outgrowth
R3377	T5378	T5364	dobj	outgrowth,sustain
R3378	T5379	T5378	compound	fiber,outgrowth
R3379	T5380	T5378	cc	and,outgrowth
R338	T863	T860	punct	',cells
R3380	T5381	T5382	det	a,maintenance
R3381	T5382	T5378	conj	maintenance,outgrowth
R3382	T5383	T5382	amod	limited,maintenance
R3383	T5384	T5364	prep	until,sustain
R3384	T5385	T5384	pobj	P0,until
R3385	T5386	T5362	punct	.,appears
R3386	T5388	T5389	det	The,level
R3387	T5389	T5392	nsubj	level,is
R3388	T5390	T5391	advmod	comparatively,high
R3389	T5391	T5389	amod	high,level
R339	T864	T860	compound	hair,cells
R3390	T5393	T5389	prep	of,level
R3391	T5394	T5395	nmod	NT,expression
R3392	T5395	T5393	pobj	expression,of
R3393	T5396	T5394	punct	-,NT
R3394	T5397	T5394	nummod	3,NT
R3395	T5398	T5389	prep	in,level
R3396	T5399	T5400	nmod	Brn3c,cochlea
R3397	T5400	T5398	pobj	cochlea,in
R3398	T5401	T5400	amod	null,cochlea
R3399	T5402	T5400	amod	mutant,cochlea
R34	T226	T210	cc	and,develop
R340	T865	T858	prep	in,form
R3400	T5403	T5389	punct	", ",level
R3401	T5404	T5405	dep	which,shown
R3402	T5405	T5389	relcl	shown,level
R3403	T5406	T5405	aux	has,shown
R3404	T5407	T5405	auxpass	been,shown
R3405	T5408	T5409	aux	to,be
R3406	T5409	T5405	xcomp	be,shown
R3407	T5410	T5411	det	the,neurotrophin
R3408	T5411	T5409	attr	neurotrophin,be
R3409	T5412	T5413	advmod	most,prominently
R341	T866	T867	nmod	Brn3c,mutants
R3410	T5413	T5414	advmod	prominently,supporting
R3411	T5414	T5411	acl	supporting,neurotrophin
R3412	T5415	T5416	amod	spiral,neurons
R3413	T5416	T5414	dobj	neurons,supporting
R3414	T5417	T5416	amod	sensory,neurons
R3415	T5418	T5419	punct	[,14
R3416	T5419	T5405	parataxis	14,shown
R3417	T5420	T5419	nummod	6,14
R3418	T5421	T5419	punct	",",14
R3419	T5422	T5419	nummod	9,14
R342	T867	T865	pobj	mutants,in
R3420	T5423	T5419	punct	",",14
R3421	T5424	T5419	punct	],14
R3422	T5425	T5392	punct	", ",is
R3423	T5426	T5392	prep	in,is
R3424	T5427	T5426	pobj	agreement,in
R3425	T5428	T5427	prep	with,agreement
R3426	T5429	T5430	det	the,development
R3427	T5430	T5428	pobj	development,with
R3428	T5431	T5430	amod	normal,development
R3429	T5432	T5430	prep	of,development
R343	T868	T867	amod	null,mutants
R3430	T5433	T5434	amod	cochlear,innervation
R3431	T5434	T5432	pobj	innervation,of
R3432	T5435	T5430	prep	in,development
R3433	T5436	T5437	amod	newborn,mutants
R3434	T5437	T5435	pobj	mutants,in
R3435	T5438	T5437	nmod	Brn3c,mutants
R3436	T5439	T5437	amod	null,mutants
R3437	T5440	T5392	punct	.,is
R3438	T5442	T5443	mark	Since,appears
R3439	T5443	T5445	advcl	appears,appears
R344	T869	T858	cc	and,form
R3440	T5444	T5443	nsubj	BDNF,appears
R3441	T5446	T5447	aux	to,produced
R3442	T5447	T5443	xcomp	produced,appears
R3443	T5448	T5447	auxpass	be,produced
R3444	T5449	T5447	advmod	exclusively,produced
R3445	T5450	T5447	agent	by,produced
R3446	T5451	T5452	compound	hair,cells
R3447	T5452	T5450	pobj	cells,by
R3448	T5453	T5454	punct	[,20
R3449	T5454	T5443	parataxis	20,appears
R345	T870	T858	conj	express,form
R3450	T5455	T5454	nummod	6,20
R3451	T5456	T5454	punct	",",20
R3452	T5457	T5454	nummod	7,20
R3453	T5458	T5454	punct	",",20
R3454	T5459	T5454	punct	],20
R3455	T5460	T5445	punct	", ",appears
R3456	T5461	T5462	det	the,lack
R3457	T5462	T5445	nsubj	lack,appears
R3458	T5463	T5462	prep	of,lack
R3459	T5464	T5465	amod	terminal,differentiation
R346	T871	T872	amod	cellular,markers
R3460	T5465	T5463	pobj	differentiation,of
R3461	T5466	T5465	prep	of,differentiation
R3462	T5467	T5468	compound	hair,cells
R3463	T5468	T5466	pobj	cells,of
R3464	T5469	T5470	aux	to,accompanied
R3465	T5470	T5445	xcomp	accompanied,appears
R3466	T5471	T5470	auxpass	be,accompanied
R3467	T5472	T5470	agent	by,accompanied
R3468	T5473	T5474	advmod	only,expression
R3469	T5474	T5472	pobj	expression,by
R347	T872	T870	dobj	markers,express
R3470	T5475	T5474	amod	limited,expression
R3471	T5476	T5474	prep	of,expression
R3472	T5477	T5476	pobj	BDNF,of
R3473	T5478	T5470	punct	", ",accompanied
R3474	T5479	T5480	mark	as,is
R3475	T5480	T5470	advcl	is,accompanied
R3476	T5481	T5482	det	the,case
R3477	T5482	T5480	attr	case,is
R3478	T5483	T5480	prep	in,is
R3479	T5484	T5485	det	the,cristae
R348	T873	T874	amod	such,as
R3480	T5485	T5483	pobj	cristae,in
R3481	T5486	T5485	compound	canal,cristae
R3482	T5487	T5488	punct	(,Fig.
R3483	T5488	T5470	parataxis	Fig.,accompanied
R3484	T5489	T5488	nummod	8,Fig.
R3485	T5490	T5488	punct	),Fig.
R3486	T5491	T5445	punct	.,appears
R3487	T5493	T5494	compound	Past,research
R3488	T5494	T5495	nsubj	research,shown
R3489	T5496	T5495	aux	has,shown
R349	T874	T872	prep	as,markers
R3490	T5497	T5498	mark	that,lost
R3491	T5498	T5495	ccomp	lost,shown
R3492	T5499	T5498	prep	in,lost
R3493	T5500	T5501	nmod	BDNF,mutants
R3494	T5501	T5499	pobj	mutants,in
R3495	T5502	T5500	cc	and,BDNF
R3496	T5503	T5500	conj	trkB,BDNF
R3497	T5504	T5501	amod	null,mutants
R3498	T5505	T5506	det	this,innervation
R3499	T5506	T5498	nsubjpass	innervation,lost
R35	T227	T210	conj	undergo,develop
R350	T875	T876	compound	Myosin,VI
R3500	T5507	T5506	prep	to,innervation
R3501	T5508	T5509	amod	canal,cristae
R3502	T5509	T5507	pobj	cristae,to
R3503	T5510	T5498	auxpass	is,lost
R3504	T5511	T5498	prep	before,lost
R3505	T5512	T5511	pobj	birth,before
R3506	T5513	T5514	punct	[,13
R3507	T5514	T5495	parataxis	13,shown
R3508	T5515	T5514	nummod	6,13
R3509	T5516	T5514	punct	",",13
R351	T876	T874	pobj	VI,as
R3510	T5517	T5514	punct	],13
R3511	T5518	T5495	punct	.,shown
R3512	T5520	T5521	mark	That,are
R3513	T5521	T5528	csubj	are,is
R3514	T5522	T5523	advmod	even,levels
R3515	T5523	T5521	nsubj	levels,are
R3516	T5524	T5523	det	these,levels
R3517	T5525	T5523	amod	low,levels
R3518	T5526	T5523	prep	of,levels
R3519	T5527	T5526	pobj	expression,of
R352	T877	T876	cc	and,VI
R3520	T5529	T5521	acomp	significant,are
R3521	T5530	T5528	acomp	clear,is
R3522	T5531	T5528	prep	from,is
R3523	T5532	T5533	det	the,fact
R3524	T5533	T5531	pobj	fact,from
R3525	T5534	T5535	mark	that,receive
R3526	T5535	T5533	acl	receive,fact
R3527	T5536	T5537	det	all,epithelia
R3528	T5537	T5535	nsubj	epithelia,receive
R3529	T5538	T5537	amod	canal,epithelia
R353	T878	T876	conj	VIIa,VI
R3530	T5539	T5537	amod	sensory,epithelia
R3531	T5540	T5541	det	an,innervation
R3532	T5541	T5535	dobj	innervation,receive
R3533	T5542	T5535	prep	by,receive
R3534	T5543	T5544	preconj	both,afferents
R3535	T5544	T5542	pobj	afferents,by
R3536	T5545	T5544	cc	and,afferents
R3537	T5546	T5544	conj	efferents,afferents
R3538	T5547	T5535	prep	at,receive
R3539	T5548	T5547	pobj	birth,at
R354	T879	T876	punct	", ",VI
R3540	T5549	T5547	cc	and,at
R3541	T5550	T5547	conj	later,at
R3542	T5551	T5552	punct	(,3
R3543	T5552	T5528	parataxis	3,is
R3544	T5553	T5552	nmod	Figs.,3
R3545	T5554	T5552	nummod	2,3
R3546	T5555	T5552	punct	", ",3
R3547	T5556	T5552	punct	),3
R3548	T5557	T5528	punct	.,is
R3549	T5559	T5560	det	The,situation
R355	T880	T876	conj	calretinin,VI
R3550	T5560	T5561	nsubj	situation,is
R3551	T5562	T5560	prep	in,situation
R3552	T5563	T5564	det	the,utricle
R3553	T5564	T5562	pobj	utricle,in
R3554	T5565	T5564	punct	", ",utricle
R3555	T5566	T5564	conj	saccule,utricle
R3556	T5567	T5566	cc	and,saccule
R3557	T5568	T5566	conj	cochlea,saccule
R3558	T5569	T5570	advmod	less,clear
R3559	T5570	T5561	acomp	clear,is
R356	T881	T880	cc	and,calretinin
R3560	T5571	T5572	mark	as,expressed
R3561	T5572	T5561	advcl	expressed,is
R3562	T5573	T5574	preconj	both,BDNF
R3563	T5574	T5572	nsubjpass	BDNF,expressed
R3564	T5575	T5574	cc	and,BDNF
R3565	T5576	T5574	conj	NT,BDNF
R3566	T5577	T5576	punct	-,NT
R3567	T5578	T5576	nummod	3,NT
R3568	T5579	T5572	auxpass	are,expressed
R3569	T5580	T5581	punct	[,7
R357	T882	T880	conj	parvalbumin,calretinin
R3570	T5581	T5561	parataxis	7,is
R3571	T5582	T5581	nummod	6,7
R3572	T5583	T5581	punct	",",7
R3573	T5584	T5581	punct	],7
R3574	T5585	T5561	punct	.,is
R3575	T5587	T5588	prep	In,appears
R3576	T5589	T5587	pobj	fact,In
R3577	T5590	T5588	punct	", ",appears
R3578	T5591	T5588	nsubj	it,appears
R3579	T5592	T5593	mark	that,differ
R358	T883	T884	punct	[,3
R3580	T5593	T5588	ccomp	differ,appears
R3581	T5594	T5595	det	the,levels
R3582	T5595	T5593	nsubj	levels,differ
R3583	T5596	T5595	prep	of,levels
R3584	T5597	T5598	nmod	NT,expression
R3585	T5598	T5596	pobj	expression,of
R3586	T5599	T5597	punct	-,NT
R3587	T5600	T5597	nummod	3,NT
R3588	T5601	T5593	advmod	hardly,differ
R3589	T5602	T5593	prep	from,differ
R359	T884	T855	parataxis	3,revealed
R3590	T5603	T5602	pobj	those,from
R3591	T5604	T5603	prep	in,those
R3592	T5605	T5606	compound	control,littermates
R3593	T5606	T5604	pobj	littermates,in
R3594	T5607	T5608	punct	(,9
R3595	T5608	T5588	parataxis	9,appears
R3596	T5609	T5608	nmod	Figs.,9
R3597	T5610	T5608	nummod	8,9
R3598	T5611	T5608	punct	", ",9
R3599	T5612	T5608	punct	),9
R36	T228	T227	dobj	apoptosis,undergo
R360	T885	T884	punct	],3
R3600	T5613	T5588	punct	.,appears
R3601	T5615	T5616	det	The,latter
R3602	T5616	T5617	nsubj	latter,is
R3603	T5618	T5619	advmod	particularly,obvious
R3604	T5619	T5617	acomp	obvious,is
R3605	T5620	T5617	prep	in,is
R3606	T5621	T5622	det	the,apex
R3607	T5622	T5620	pobj	apex,in
R3608	T5623	T5622	prep	of,apex
R3609	T5624	T5625	det	the,cochlea
R361	T886	T855	punct	.,revealed
R3610	T5625	T5623	pobj	cochlea,of
R3611	T5626	T5617	punct	.,is
R3612	T5628	T5629	prep	In,expressed
R3613	T5630	T5628	pobj	fact,In
R3614	T5631	T5629	punct	", ",expressed
R3615	T5632	T5629	prep	in,expressed
R3616	T5633	T5634	det	the,cochlea
R3617	T5634	T5632	pobj	cochlea,in
R3618	T5635	T5634	prep	of,cochlea
R3619	T5636	T5635	pobj	embryos,of
R362	T888	T889	advmod	Furthermore,undergo
R3620	T5637	T5636	cc	and,embryos
R3621	T5638	T5636	conj	neonates,embryos
R3622	T5639	T5640	advmod	as,as
R3623	T5640	T5632	cc	as,in
R3624	T5641	T5640	advmod	well,as
R3625	T5642	T5632	conj	in,in
R3626	T5643	T5644	det	the,saccule
R3627	T5644	T5642	pobj	saccule,in
R3628	T5645	T5644	cc	and,saccule
R3629	T5646	T5644	conj	utricle,saccule
R363	T890	T889	punct	", ",undergo
R3630	T5647	T5644	prep	of,saccule
R3631	T5648	T5647	pobj	embryos,of
R3632	T5649	T5629	punct	", ",expressed
R3633	T5650	T5629	nsubjpass	NT,expressed
R3634	T5651	T5650	punct	-,NT
R3635	T5652	T5650	nummod	3,NT
R3636	T5653	T5629	auxpass	is,expressed
R3637	T5654	T5629	advmod	predominantly,expressed
R3638	T5655	T5629	prep	in,expressed
R3639	T5656	T5657	amod	supporting,cells
R364	T891	T892	det	these,cells
R3640	T5657	T5655	pobj	cells,in
R3641	T5658	T5659	punct	[,6
R3642	T5659	T5629	parataxis	6,expressed
R3643	T5660	T5659	punct	],6
R3644	T5661	T5629	punct	.,expressed
R3645	T5663	T5664	det	This,expression
R3646	T5664	T5665	nsubj	expression,preserve
R3647	T5666	T5664	prep	of,expression
R3648	T5667	T5666	pobj	NT,of
R3649	T5668	T5667	punct	-,NT
R365	T892	T889	nsubj	cells,undergo
R3650	T5669	T5667	nummod	3,NT
R3651	T5670	T5664	prep	in,expression
R3652	T5671	T5672	amod	supporting,cells
R3653	T5672	T5670	pobj	cells,in
R3654	T5673	T5664	prep	in,expression
R3655	T5674	T5673	pobj	embryos,in
R3656	T5675	T5674	cc	and,embryos
R3657	T5676	T5674	conj	neonates,embryos
R3658	T5677	T5665	aux	may,preserve
R3659	T5678	T5665	advmod	even,preserve
R366	T893	T892	amod	immature,cells
R3660	T5679	T5665	prep	in,preserve
R3661	T5680	T5681	nmod	Brn3c,mutants
R3662	T5681	T5679	pobj	mutants,in
R3663	T5682	T5681	amod	null,mutants
R3664	T5683	T5684	det	the,neurons
R3665	T5684	T5665	dobj	neurons,preserve
R3666	T5685	T5684	amod	numerous,neurons
R3667	T5686	T5684	amod	spiral,neurons
R3668	T5687	T5684	amod	sensory,neurons
R3669	T5688	T5684	prep	in,neurons
R367	T894	T892	compound	hair,cells
R3670	T5689	T5690	det	the,apex
R3671	T5690	T5688	pobj	apex,in
R3672	T5691	T5690	prep	of,apex
R3673	T5692	T5693	nummod	8,day
R3674	T5693	T5695	npadvmod	day,old
R3675	T5694	T5693	punct	-,day
R3676	T5695	T5696	amod	old,animals
R3677	T5696	T5691	pobj	animals,of
R3678	T5697	T5698	punct	(,4
R3679	T5698	T5665	parataxis	4,preserve
R368	T895	T892	prep	of,cells
R3680	T5699	T5698	nmod	Figs.,4
R3681	T5700	T5698	nummod	3,4
R3682	T5701	T5698	punct	", ",4
R3683	T5702	T5698	punct	),4
R3684	T5703	T5665	punct	.,preserve
R3689	T5839	T5840	amod	Long,term
R369	T896	T897	nmod	Brn3c,mutants
R3690	T5840	T5841	compound	term,survival
R3691	T5841	T5842	nsubj	survival,is
R3692	T5843	T5841	prep	of,survival
R3693	T5844	T5845	amod	apical,neurons
R3694	T5845	T5843	pobj	neurons,of
R3695	T5846	T5845	amod	sensory,neurons
R3696	T5847	T5842	acomp	unrelated,is
R3697	T5848	T5847	prep	to,unrelated
R3698	T5849	T5850	amod	differentiated,cells
R3699	T5850	T5848	pobj	cells,to
R37	T229	T227	prep	in,undergo
R370	T897	T895	pobj	mutants,of
R3700	T5851	T5850	compound	hair,cells
R3701	T5852	T5842	cc	and,is
R3702	T5853	T5854	advmod	likely,is
R3703	T5854	T5842	conj	is,is
R3704	T5855	T5854	acomp	independent,is
R3705	T5856	T5855	prep	of,independent
R3706	T5857	T5856	pobj	neurotrophins,of
R3707	T5859	T5860	compound	Past,work
R3708	T5860	T5861	nsubj	work,shown
R3709	T5862	T5861	aux	has,shown
R371	T898	T897	amod	null,mutants
R3710	T5863	T5864	mark	that,appear
R3711	T5864	T5861	ccomp	appear,shown
R3712	T5865	T5864	nsubj	BDNF,appear
R3713	T5866	T5865	cc	and,BDNF
R3714	T5867	T5865	conj	NT,BDNF
R3715	T5868	T5867	punct	-,NT
R3716	T5869	T5867	nummod	3,NT
R3717	T5870	T5871	aux	to,shift
R3718	T5871	T5864	xcomp	shift,appear
R3719	T5872	T5871	prep	in,shift
R372	T899	T889	dobj	apoptosis,undergo
R3720	T5873	T5874	poss	their,expression
R3721	T5874	T5872	pobj	expression,in
R3722	T5875	T5871	prep	into,shift
R3723	T5876	T5877	amod	inner,cells
R3724	T5877	T5875	pobj	cells,into
R3725	T5878	T5877	compound	hair,cells
R3726	T5879	T5871	prep	around,shift
R3727	T5880	T5879	pobj	birth,around
R3728	T5881	T5864	cc	or,appear
R3729	T5882	T5883	auxpass	are,lost
R373	T900	T889	prep	in,undergo
R3730	T5883	T5864	conj	lost,appear
R3731	T5884	T5883	prep	in,lost
R3732	T5885	T5886	det	the,ear
R3733	T5886	T5884	pobj	ear,in
R3734	T5887	T5886	cc	and,ear
R3735	T5888	T5889	amod	other,parts
R3736	T5889	T5886	conj	parts,ear
R3737	T5890	T5889	prep	of,parts
R3738	T5891	T5892	det	the,system
R3739	T5892	T5890	pobj	system,of
R374	T901	T900	pobj	neonates,in
R3740	T5893	T5892	amod	nervous,system
R3741	T5894	T5895	punct	[,23
R3742	T5895	T5861	parataxis	23,shown
R3743	T5896	T5895	nummod	6,23
R3744	T5897	T5895	punct	",",23
R3745	T5898	T5895	nummod	10,23
R3746	T5899	T5895	punct	",",23
R3747	T5900	T5895	nummod	20,23
R3748	T5901	T5895	punct	",",23
R3749	T5902	T5895	punct	],23
R375	T902	T903	punct	[,3
R3750	T5903	T5861	punct	.,shown
R3751	T5905	T5906	nsubjpass	It,suggested
R3752	T5907	T5906	aux	has,suggested
R3753	T5908	T5906	auxpass	been,suggested
R3754	T5909	T5910	mark	that,come
R3755	T5910	T5906	ccomp	come,suggested
R3756	T5911	T5912	amod	other,neurotrophins
R3757	T5912	T5910	nsubj	neurotrophins,come
R3758	T5913	T5910	aux	may,come
R3759	T5914	T5910	prep	into,come
R376	T903	T889	parataxis	3,undergo
R3760	T5915	T5914	pobj	play,into
R3761	T5916	T5910	prep	in,come
R3762	T5917	T5918	det	the,ear
R3763	T5918	T5916	pobj	ear,in
R3764	T5919	T5920	punct	[,11
R3765	T5920	T5906	parataxis	11,suggested
R3766	T5921	T5920	punct	],11
R3767	T5922	T5906	punct	.,suggested
R3768	T5924	T5925	advmod	However,shows
R3769	T5926	T5925	punct	", ",shows
R377	T904	T903	punct	],3
R3770	T5927	T5928	det	the,apex
R3771	T5928	T5925	nsubj	apex,shows
R3772	T5929	T5928	prep	of,apex
R3773	T5930	T5931	nmod	Brn3c,mutants
R3774	T5931	T5929	pobj	mutants,of
R3775	T5932	T5931	amod	null,mutants
R3776	T5933	T5928	punct	", ",apex
R3777	T5934	T5935	dep	which,retains
R3778	T5935	T5928	relcl	retains,apex
R3779	T5936	T5935	dobj	most,retains
R378	T905	T889	punct	.,undergo
R3780	T5937	T5936	prep	of,most
R3781	T5938	T5939	det	the,afferents
R3782	T5939	T5937	pobj	afferents,of
R3783	T5940	T5941	amod	spiral,neuron
R3784	T5941	T5939	compound	neuron,afferents
R3785	T5942	T5935	prep	at,retains
R3786	T5943	T5944	nummod	6,month
R3787	T5944	T5942	pobj	month,at
R3788	T5945	T5944	punct	-,month
R3789	T5946	T5925	punct	", ",shows
R379	T907	T908	advcl	Consistent,suggested
R3790	T5947	T5948	det	no,formation
R3791	T5948	T5925	dobj	formation,shows
R3792	T5949	T5948	prep	of,formation
R3793	T5950	T5951	amod	mature,cells
R3794	T5951	T5949	pobj	cells,of
R3795	T5952	T5951	compound	hair,cells
R3796	T5953	T5925	prep	at,shows
R3797	T5954	T5955	det	any,time
R3798	T5955	T5953	pobj	time,at
R3799	T5956	T5955	acl	surveyed,time
R38	T230	T229	pobj	neonates,in
R380	T909	T907	prep	with,Consistent
R3800	T5957	T5956	advmod	here,surveyed
R3801	T5958	T5959	punct	(,P10
R3802	T5959	T5925	parataxis	P10,shows
R3803	T5960	T5959	nmod	P0,P10
R3804	T5961	T5959	punct	", ",P10
R3805	T5962	T5959	nmod	P8,P10
R3806	T5963	T5959	punct	", ",P10
R3807	T5964	T5959	punct	),P10
R3808	T5965	T5925	punct	.,shows
R3809	T5967	T5968	advmod	Thus,released
R381	T910	T911	det	an,absence
R3810	T5969	T5970	det	the,factor
R3811	T5970	T5968	nsubjpass	factor,released
R3812	T5971	T5970	punct	(,factor
R3813	T5972	T5970	nmod	s,factor
R3814	T5973	T5970	punct	),factor
R3815	T5974	T5968	aux	can,released
R3816	T5975	T5968	neg	not,released
R3817	T5976	T5968	auxpass	be,released
R3818	T5977	T5968	agent	by,released
R3819	T5978	T5979	amod	differentiated,cells
R382	T911	T909	pobj	absence,with
R3820	T5979	T5977	pobj	cells,by
R3821	T5980	T5979	compound	hair,cells
R3822	T5981	T5968	cc	but,released
R3823	T5982	T5983	expl	there,is
R3824	T5983	T5968	conj	is,released
R3825	T5984	T5985	det	an,possibility
R3826	T5985	T5983	attr	possibility,is
R3827	T5986	T5985	amod	unexplored,possibility
R3828	T5987	T5985	prep	of,possibility
R3829	T5988	T5989	amod	generalized,expression
R383	T912	T911	amod	apparent,absence
R3830	T5989	T5987	pobj	expression,of
R3831	T5990	T5989	prep	of,expression
R3832	T5991	T5990	pobj	neurotrophins,of
R3833	T5992	T5989	prep	at,expression
R3834	T5993	T5994	amod	low,levels
R3835	T5994	T5992	pobj	levels,at
R3836	T5995	T5989	prep	in,expression
R3837	T5996	T5997	det	the,epithelia
R3838	T5997	T5995	pobj	epithelia,in
R3839	T5998	T5997	amod	undifferentiated,epithelia
R384	T913	T911	prep	of,absence
R3840	T5999	T5968	punct	.,released
R3841	T6001	T6002	advmod	However,are
R3842	T6003	T6002	punct	", ",are
R3843	T6004	T6005	amod	known,neurotrophins
R3844	T6005	T6002	nsubj	neurotrophins,are
R3845	T6006	T6007	advmod	largely,absent
R3846	T6007	T6002	acomp	absent,are
R3847	T6008	T6002	prep	in,are
R3848	T6009	T6010	det	the,cochleae
R3849	T6010	T6008	pobj	cochleae,in
R385	T914	T915	amod	mature,cells
R3850	T6011	T6010	amod	adult,cochleae
R3851	T6012	T6013	punct	[,4
R3852	T6013	T6002	parataxis	4,are
R3853	T6014	T6013	punct	],4
R3854	T6015	T6002	cc	and,are
R3855	T6016	T6017	amod	significant,amounts
R3856	T6017	T6018	nsubj	amounts,appear
R3857	T6018	T6002	conj	appear,are
R3858	T6019	T6017	prep	of,amounts
R3859	T6020	T6021	compound	neurotrophin,expression
R386	T915	T913	pobj	cells,of
R3860	T6021	T6019	pobj	expression,of
R3861	T6022	T6023	aux	to,develop
R3862	T6023	T6018	xcomp	develop,appear
R3863	T6024	T6023	advmod	only,develop
R3864	T6025	T6023	prep	in,develop
R3865	T6026	T6027	amod	postnatal,animals
R3866	T6027	T6025	pobj	animals,in
R3867	T6028	T6023	prep	in,develop
R3868	T6029	T6030	det	the,CNS
R3869	T6030	T6028	pobj	CNS,in
R387	T916	T915	compound	hair,cells
R3870	T6031	T6032	punct	[,24
R3871	T6032	T6018	parataxis	24,appear
R3872	T6033	T6032	punct	],24
R3873	T6034	T6002	punct	.,are
R3874	T6036	T6037	amod	Such,expression
R3875	T6037	T6038	nsubj	expression,offset
R3876	T6039	T6037	prep	in,expression
R3877	T6040	T6041	det	the,CNS
R3878	T6041	T6039	pobj	CNS,in
R3879	T6042	T6038	aux	could,offset
R388	T917	T908	punct	", ",suggested
R3880	T6043	T6038	advmod	possibly,offset
R3881	T6044	T6038	prep	to,offset
R3882	T6045	T6046	det	some,extent
R3883	T6046	T6044	pobj	extent,to
R3884	T6047	T6048	det	the,loss
R3885	T6048	T6038	dobj	loss,offset
R3886	T6049	T6048	amod	peripheral,loss
R3887	T6050	T6048	prep	of,loss
R3888	T6051	T6050	pobj	neutrophins,of
R3889	T6052	T6038	prep	in,offset
R389	T918	T919	amod	initial,work
R3890	T6053	T6054	amod	targeted,mutants
R3891	T6054	T6052	pobj	mutants,in
R3892	T6055	T6054	amod	null,mutants
R3893	T6056	T6038	punct	.,offset
R3894	T6058	T6059	nsubj	This,work
R3895	T6060	T6059	aux	would,work
R3896	T6061	T6062	advmod	only,in
R3897	T6062	T6059	prep	in,work
R3898	T6063	T6062	pobj	cases,in
R3899	T6064	T6065	prep	in,completed
R39	T231	T210	punct	.,develop
R390	T919	T908	nsubj	work,suggested
R3900	T6065	T6063	relcl	completed,cases
R3901	T6066	T6064	pobj	which,in
R3902	T6067	T6068	det	the,loss
R3903	T6068	T6065	nsubjpass	loss,completed
R3904	T6069	T6068	prep	of,loss
R3905	T6070	T6071	amod	primary,neurons
R3906	T6071	T6069	pobj	neurons,of
R3907	T6072	T6065	aux	would,completed
R3908	T6073	T6065	neg	not,completed
R3909	T6074	T6065	advmod	already,completed
R391	T920	T921	mark	that,lost
R3910	T6075	T6065	auxpass	be,completed
R3911	T6076	T6077	advmod	long,before
R3912	T6077	T6065	prep	before,completed
R3913	T6078	T6077	pobj	birth,before
R3914	T6079	T6080	mark	as,is
R3915	T6080	T6065	advcl	is,completed
R3916	T6081	T6082	det	the,case
R3917	T6082	T6080	nsubj	case,is
R3918	T6083	T6080	prep	in,is
R3919	T6084	T6085	det	the,ear
R392	T921	T908	ccomp	lost,suggested
R3920	T6085	T6083	pobj	ear,in
R3921	T6086	T6087	punct	[,13
R3922	T6087	T6059	parataxis	13,work
R3923	T6088	T6087	nummod	6,13
R3924	T6089	T6087	punct	",",13
R3925	T6090	T6087	punct	],13
R3926	T6091	T6059	punct	.,work
R3927	T6093	T6094	nsubj	It,remains
R3928	T6095	T6094	advmod	therefore,remains
R3929	T6096	T6094	acomp	unclear,remains
R393	T922	T923	det	all,vestibular
R3930	T6097	T6098	dep	what,supports
R3931	T6098	T6094	ccomp	supports,remains
R3932	T6099	T6100	det	the,afferents
R3933	T6100	T6098	dative	afferents,supports
R3934	T6101	T6100	amod	many,afferents
R3935	T6102	T6100	prep	in,afferents
R3936	T6103	T6104	det	the,apex
R3937	T6104	T6102	pobj	apex,in
R3938	T6105	T6104	prep	of,apex
R3939	T6106	T6107	det	the,mutants
R394	T923	T921	nsubjpass	vestibular,lost
R3940	T6107	T6105	pobj	mutants,of
R3941	T6108	T6107	nmod	Brn3c,mutants
R3942	T6109	T6107	amod	null,mutants
R3943	T6110	T6100	prep	until,afferents
R3944	T6111	T6112	nummod	6,months
R3945	T6112	T6110	pobj	months,until
R3946	T6113	T6112	prep	of,months
R3947	T6114	T6113	pobj	age,of
R3948	T6115	T6116	cc	or,longer
R3949	T6116	T6112	nummod	longer,months
R395	T924	T923	cc	and,vestibular
R3950	T6117	T6098	punct	", ",supports
R3951	T6118	T6119	amod	unknown,substances
R3952	T6119	T6098	dobj	substances,supports
R3953	T6120	T6119	amod	peripheral,substances
R3954	T6121	T6119	amod	neurotrophic,substances
R3955	T6122	T6119	cc	or,substances
R3956	T6123	T6124	amod	neurotrophic,support
R3957	T6124	T6119	conj	support,substances
R3958	T6125	T6124	acl	provided,support
R3959	T6126	T6125	agent	by,provided
R396	T925	T926	det	most,spiral
R3960	T6127	T6128	det	the,CNS
R3961	T6128	T6126	pobj	CNS,by
R3962	T6129	T6094	punct	.,remains
R3963	T6131	T6132	amod	Comparable,retention
R3964	T6132	T6135	nsubjpass	retention,described
R3965	T6133	T6134	amod	long,term
R3966	T6134	T6132	compound	term,retention
R3967	T6136	T6132	prep	of,retention
R3968	T6137	T6138	amod	apical,neurons
R3969	T6138	T6136	pobj	neurons,of
R397	T926	T927	nmod	spiral,cells
R3970	T6139	T6138	amod	spiral,neurons
R3971	T6140	T6138	amod	sensory,neurons
R3972	T6141	T6135	auxpass	was,described
R3973	T6142	T6135	prep	for,described
R3974	T6143	T6144	det	the,cat
R3975	T6144	T6142	pobj	cat,for
R3976	T6145	T6144	nmod	deaf,cat
R3977	T6146	T6144	amod	white,cat
R3978	T6147	T6148	punct	[,25
R3979	T6148	T6135	parataxis	25,described
R398	T927	T923	conj	cells,vestibular
R3980	T6149	T6148	punct	],25
R3981	T6150	T6135	cc	and,described
R3982	T6151	T6152	aux	may,be
R3983	T6152	T6135	conj	be,described
R3984	T6153	T6152	advmod	also,be
R3985	T6154	T6155	det	the,case
R3986	T6155	T6152	attr	case,be
R3987	T6156	T6152	prep	in,be
R3988	T6157	T6156	pobj	humans,in
R3989	T6158	T6157	prep	with,humans
R399	T928	T927	compound	ganglion,cells
R3990	T6159	T6160	amod	congenital,deafness
R3991	T6160	T6158	pobj	deafness,with
R3992	T6161	T6135	punct	.,described
R4	T190	T192	nsubj	mice,show
R40	T233	T234	det	This,development
R400	T929	T921	auxpass	are,lost
R4005	T6395	T6396	nsubj	Growth,require
R4006	T6397	T6395	prep	of,Growth
R4007	T6398	T6397	pobj	fibers,of
R4008	T6399	T6395	prep	to,Growth
R4009	T6400	T6401	det	the,cochlea
R401	T930	T921	prep	by,lost
R4010	T6401	T6399	pobj	cochlea,to
R4011	T6402	T6396	aux	does,require
R4012	T6403	T6396	neg	not,require
R4013	T6404	T6405	amod	mature,cells
R4014	T6405	T6396	dobj	cells,require
R4015	T6406	T6405	compound	hair,cells
R4016	T6408	T6409	nsubj	Formation,seems
R4017	T6410	T6408	prep	of,Formation
R4018	T6411	T6412	compound	radial,fibers
R4019	T6412	T6410	pobj	fibers,of
R402	T931	T932	amod	postnatal,day
R4020	T6413	T6414	dep	that,bring
R4021	T6414	T6412	relcl	bring,fibers
R4022	T6415	T6416	amod	peripheral,processes
R4023	T6416	T6414	dobj	processes,bring
R4024	T6417	T6416	prep	of,processes
R4025	T6418	T6419	amod	spiral,neurons
R4026	T6419	T6417	pobj	neurons,of
R4027	T6420	T6414	prep	to,bring
R4028	T6421	T6422	det	the,organ
R4029	T6422	T6420	pobj	organ,to
R403	T932	T930	pobj	day,by
R4030	T6423	T6422	prep	of,organ
R4031	T6424	T6423	pobj	Corti,of
R4032	T6425	T6426	aux	to,be
R4033	T6426	T6409	xcomp	be,seems
R4034	T6427	T6428	advmod	rather,normal
R4035	T6428	T6426	acomp	normal,be
R4036	T6429	T6426	punct	", ",be
R4037	T6430	T6431	advmod	even,in
R4038	T6431	T6426	prep	in,be
R4039	T6432	T6433	det	the,apex
R404	T933	T932	nummod	14,day
R4040	T6433	T6431	pobj	apex,in
R4041	T6434	T6433	prep	of,apex
R4042	T6435	T6436	det	the,cochlea
R4043	T6436	T6434	pobj	cochlea,of
R4044	T6437	T6438	dep	which,develop
R4045	T6438	T6433	relcl	develop,apex
R4046	T6439	T6438	aux	does,develop
R4047	T6440	T6438	neg	not,develop
R4048	T6441	T6438	advmod	even,develop
R4049	T6442	T6443	amod	immature,cells
R405	T934	T932	punct	(,day
R4050	T6443	T6438	dobj	cells,develop
R4051	T6444	T6443	compound	hair,cells
R4052	T6445	T6443	amod	recognizable,cells
R4053	T6446	T6445	prep	by,recognizable
R4054	T6447	T6448	compound	Myo,VIIa
R4055	T6448	T6446	pobj	VIIa,by
R4056	T6449	T6409	punct	.,seems
R4057	T6451	T6452	nsubj	This,preclude
R4058	T6453	T6452	aux	does,preclude
R4059	T6454	T6452	neg	not,preclude
R406	T935	T932	appos	P14,day
R4060	T6455	T6456	mark	that,form
R4061	T6456	T6452	advcl	form,preclude
R4062	T6457	T6458	advmod	even,less
R4063	T6458	T6459	advmod	less,differentiated
R4064	T6459	T6460	amod	differentiated,precursors
R4065	T6460	T6456	nsubj	precursors,form
R4066	T6461	T6462	compound	hair,cell
R4067	T6462	T6460	compound	cell,precursors
R4068	T6463	T6456	aux	may,form
R4069	T6464	T6456	prep	in,form
R407	T936	T921	punct	;,lost
R4070	T6465	T6466	det	the,apex
R4071	T6466	T6464	pobj	apex,in
R4072	T6467	T6456	cc	or,form
R4073	T6468	T6469	mark	that,died
R4074	T6469	T6456	conj	died,form
R4075	T6470	T6471	det	those,precursors
R4076	T6471	T6469	nsubj	precursors,died
R4077	T6472	T6469	aux	have,died
R4078	T6473	T6469	prep	before,died
R4079	T6474	T6473	pobj	birth,before
R408	T937	T938	punct	[,1
R4080	T6475	T6452	punct	.,preclude
R4081	T6477	T6478	advmod	Interestingly,affected
R4082	T6479	T6478	punct	", ",affected
R4083	T6480	T6481	det	the,growth
R4084	T6481	T6478	nsubjpass	growth,affected
R4085	T6482	T6481	prep	to,growth
R4086	T6483	T6484	amod	outer,cells
R4087	T6484	T6482	pobj	cells,to
R4088	T6485	T6484	compound	hair,cells
R4089	T6486	T6478	auxpass	is,affected
R409	T938	T921	parataxis	1,lost
R4090	T6487	T6478	advmod	most,affected
R4091	T6488	T6478	prep	in,affected
R4092	T6489	T6490	nmod	Brn3c,cochleae
R4093	T6490	T6488	pobj	cochleae,in
R4094	T6491	T6490	amod	null,cochleae
R4095	T6492	T6490	amod	mutant,cochleae
R4096	T6493	T6478	punct	.,affected
R4097	T6495	T6496	advmod	Instead,of
R4098	T6496	T6497	prep	of,appear
R4099	T6498	T6496	pcomp	extending,of
R41	T234	T236	nsubj	development,lead
R410	T939	T938	punct	],1
R4100	T6499	T6498	advmod	radially,extending
R4101	T6500	T6498	prep	through,extending
R4102	T6501	T6502	det	the,tunnel
R4103	T6502	T6500	pobj	tunnel,through
R4104	T6503	T6502	prep	of,tunnel
R4105	T6504	T6503	pobj	Corti,of
R4106	T6505	T6498	prep	to,extending
R4107	T6506	T6507	amod	outer,cells
R4108	T6507	T6505	pobj	cells,to
R4109	T6508	T6507	compound	hair,cells
R411	T940	T921	punct	),lost
R4110	T6509	T6497	punct	", ",appear
R4111	T6510	T6497	nsubj	afferents,appear
R4112	T6511	T6512	aux	to,stall
R4113	T6512	T6497	xcomp	stall,appear
R4114	T6513	T6512	cc	and,stall
R4115	T6514	T6512	conj	extend,stall
R4116	T6515	T6514	prep	in,extend
R4117	T6516	T6517	amod	longitudinal,directions
R4118	T6517	T6515	pobj	directions,in
R4119	T6518	T6514	prep	as,extend
R412	T941	T908	punct	.,suggested
R4120	T6519	T6520	amod	inner,bundles
R4121	T6520	T6518	pobj	bundles,as
R4122	T6521	T6520	amod	spiral,bundles
R4123	T6522	T6523	punct	(,7
R4124	T6523	T6497	parataxis	7,appear
R4125	T6524	T6523	nmod	Figs.,7
R4126	T6525	T6523	nummod	3,7
R4127	T6526	T6523	punct	", ",7
R4128	T6527	T6523	punct	),7
R4129	T6528	T6497	punct	.,appear
R413	T943	T944	advmod	However,reported
R4130	T6530	T6531	nsubjpass	It,shown
R4131	T6532	T6531	aux	has,shown
R4132	T6533	T6531	auxpass	been,shown
R4133	T6534	T6535	mark	that,depends
R4134	T6535	T6531	ccomp	depends,shown
R4135	T6536	T6537	det	the,differentiation
R4136	T6537	T6535	nsubj	differentiation,depends
R4137	T6538	T6537	prep	of,differentiation
R4138	T6539	T6540	amod	pillar,cells
R4139	T6540	T6538	pobj	cells,of
R414	T945	T944	punct	", ",reported
R4140	T6541	T6535	prep	on,depends
R4141	T6542	T6541	pobj	activation,on
R4142	T6543	T6542	prep	of,activation
R4143	T6544	T6543	pobj	Fgfr3,of
R4144	T6545	T6546	punct	[,26
R4145	T6546	T6544	parataxis	26,Fgfr3
R4146	T6547	T6546	punct	],26
R4147	T6548	T6542	prep	by,activation
R4148	T6549	T6550	poss	FGF,Fgf8
R4149	T6550	T6548	pobj	Fgf8,by
R415	T946	T947	advmod	more,quantification
R4150	T6551	T6549	case	's,FGF
R4151	T6552	T6550	punct	", ",Fgf8
R4152	T6553	T6550	advmod	probably,Fgf8
R4153	T6554	T6550	punct	", ",Fgf8
R4154	T6555	T6556	det	a,factor
R4155	T6556	T6550	appos	factor,Fgf8
R4156	T6557	T6556	acl	produced,factor
R4157	T6558	T6557	agent	by,produced
R4158	T6559	T6560	amod	developing,cells
R4159	T6560	T6558	pobj	cells,by
R416	T947	T944	nsubj	quantification,reported
R4160	T6561	T6559	cc	and,developing
R4161	T6562	T6559	conj	mature,developing
R4162	T6563	T6560	amod	inner,cells
R4163	T6564	T6560	compound	hair,cells
R4164	T6565	T6566	punct	[,27
R4165	T6566	T6535	parataxis	27,depends
R4166	T6567	T6566	nummod	18,27
R4167	T6568	T6566	punct	",",27
R4168	T6569	T6566	punct	],27
R4169	T6570	T6531	punct	.,shown
R417	T948	T947	amod	detailed,quantification
R4170	T6572	T6573	det	The,formation
R4171	T6573	T6574	nsubj	formation,appears
R4172	T6575	T6573	prep	of,formation
R4173	T6576	T6577	amod	supporting,cells
R4174	T6577	T6575	pobj	cells,of
R4175	T6578	T6574	advmod	also,appears
R4176	T6579	T6580	aux	to,depend
R4177	T6580	T6574	xcomp	depend,appears
R4178	T6581	T6580	prep	on,depend
R4179	T6582	T6583	det	the,expression
R418	T949	T947	prep	by,quantification
R4180	T6583	T6581	pobj	expression,on
R4181	T6584	T6583	amod	proper,expression
R4182	T6585	T6583	prep	of,expression
R4183	T6586	T6587	amod	various,factors
R4184	T6587	T6585	pobj	factors,of
R4185	T6588	T6587	amod	bHLH,factors
R4186	T6589	T6590	amod	such,as
R4187	T6590	T6583	prep	as,expression
R4188	T6591	T6592	nmod	Hes,1
R4189	T6592	T6590	pobj	1,as
R419	T950	T949	pobj	others,by
R4190	T6593	T6592	cc	and,1
R4191	T6594	T6592	conj	5,1
R4192	T6595	T6596	dep	which,appear
R4193	T6596	T6592	relcl	appear,1
R4194	T6597	T6598	aux	to,regulated
R4195	T6598	T6596	xcomp	regulated,appear
R4196	T6599	T6598	auxpass	be,regulated
R4197	T6600	T6598	agent	by,regulated
R4198	T6601	T6602	det	the,pathway
R4199	T6602	T6600	pobj	pathway,by
R42	T235	T234	amod	partial,development
R420	T951	T952	punct	[,3
R4200	T6603	T6602	compound	Notch,pathway
R4201	T6604	T6602	compound	signaling,pathway
R4202	T6605	T6606	punct	[,29
R4203	T6606	T6574	parataxis	29,appears
R4204	T6607	T6606	nummod	17,29
R4205	T6608	T6606	punct	",",29
R4206	T6609	T6606	nummod	28,29
R4207	T6610	T6606	punct	",",29
R4208	T6611	T6606	punct	],29
R4209	T6612	T6574	punct	.,appears
R421	T952	T947	parataxis	3,quantification
R4210	T6614	T6615	nsubj	It,is
R4211	T6616	T6615	acomp	possible,is
R4212	T6617	T6618	mark	that,is
R4213	T6618	T6615	ccomp	is,is
R4214	T6619	T6620	det	the,inability
R4215	T6620	T6618	nsubj	inability,is
R4216	T6621	T6620	amod	apparent,inability
R4217	T6622	T6620	prep	of,inability
R4218	T6623	T6622	pobj	fibers,of
R4219	T6624	T6625	aux	to,extend
R422	T953	T952	punct	],3
R4220	T6625	T6620	acl	extend,inability
R4221	T6626	T6625	prep	along,extend
R4222	T6627	T6628	amod	outer,cells
R4223	T6628	T6626	pobj	cells,along
R4224	T6629	T6628	compound	hair,cells
R4225	T6630	T6618	acomp	related,is
R4226	T6631	T6630	prep	to,related
R4227	T6632	T6633	det	the,lack
R4228	T6633	T6631	pobj	lack,to
R4229	T6634	T6633	prep	of,lack
R423	T954	T955	mark	that,lost
R4230	T6635	T6634	pobj	differentiation,of
R4231	T6636	T6635	prep	of,differentiation
R4232	T6637	T6638	amod	supporting,cells
R4233	T6638	T6636	pobj	cells,of
R4234	T6639	T6635	prep	in,differentiation
R4235	T6640	T6641	det	the,absence
R4236	T6641	T6639	pobj	absence,in
R4237	T6642	T6641	prep	of,absence
R4238	T6643	T6644	amod	mature,cells
R4239	T6644	T6642	pobj	cells,of
R424	T955	T944	ccomp	lost,reported
R4240	T6645	T6644	compound	hair,cells
R4241	T6646	T6615	punct	.,is
R4242	T6648	T6649	nsubj	Probing,is
R4243	T6650	T6648	prep	for,Probing
R4244	T6651	T6652	det	the,expression
R4245	T6652	T6650	pobj	expression,for
R4246	T6653	T6652	amod	proper,expression
R4247	T6654	T6652	prep	of,expression
R4248	T6655	T6656	amod	supporting,markers
R4249	T6656	T6654	pobj	markers,of
R425	T956	T955	prep	at,lost
R4250	T6657	T6658	npadvmod	cell,specific
R4251	T6658	T6656	amod	specific,markers
R4252	T6659	T6648	prep	in,Probing
R4253	T6660	T6661	nmod	Brn3c,mutants
R4254	T6661	T6659	pobj	mutants,in
R4255	T6662	T6661	amod	null,mutants
R4256	T6663	T6649	acomp	necessary,is
R4257	T6664	T6665	aux	to,evaluate
R4258	T6665	T6649	advcl	evaluate,is
R4259	T6666	T6665	advmod	further,evaluate
R426	T957	T956	pobj	P4,at
R4260	T6667	T6668	det	these,suggestions
R4261	T6668	T6665	dobj	suggestions,evaluate
R4262	T6669	T6649	punct	.,is
R4263	T6671	T6672	amod	Previous,work
R4264	T6672	T6673	nsubj	work,suggested
R4265	T6674	T6673	aux	has,suggested
R4266	T6675	T6676	mark	that,follow
R4267	T6676	T6673	ccomp	follow,suggested
R4268	T6677	T6678	amod	efferent,fibers
R4269	T6678	T6676	nsubj	fibers,follow
R427	T958	T959	quantmod	about,77
R4270	T6679	T6678	punct	", ",fibers
R4271	T6680	T6678	acl	derived,fibers
R4272	T6681	T6680	prep	from,derived
R4273	T6682	T6683	amod	facial,motoneurons
R4274	T6683	T6681	pobj	motoneurons,from
R4275	T6684	T6683	amod	branchial,motoneurons
R4276	T6685	T6676	punct	", ",follow
R4277	T6686	T6676	dobj	afferents,follow
R4278	T6687	T6676	cc	and,follow
R4279	T6688	T6689	prep	for,reflect
R428	T959	T960	nummod	77,%
R4280	T6689	T6676	conj	reflect,follow
R4281	T6690	T6691	det	that,reason
R4282	T6691	T6688	pobj	reason,for
R4283	T6692	T6689	prep	in,reflect
R4284	T6693	T6692	pobj	detail,in
R4285	T6694	T6695	det	all,deviations
R4286	T6695	T6689	dobj	deviations,reflect
R4287	T6696	T6695	amod	connectional,deviations
R4288	T6697	T6695	prep	of,deviations
R4289	T6698	T6697	pobj	afferents,of
R429	T960	T955	nsubjpass	%,lost
R4290	T6699	T6700	punct	[,32
R4291	T6700	T6673	parataxis	32,suggested
R4292	T6701	T6700	nummod	16,32
R4293	T6702	T6700	punct	",",32
R4294	T6703	T6700	nummod	30,32
R4295	T6704	T6700	punct	-,32
R4296	T6705	T6700	punct	],32
R4297	T6706	T6673	punct	.,suggested
R4298	T6708	T6709	poss	Our,data
R4299	T6709	T6710	nsubj	data,agree
R43	T237	T234	prep	of,development
R430	T961	T960	prep	of,%
R4300	T6711	T6710	prep	with,agree
R4301	T6712	T6713	det	this,scenario
R4302	T6713	T6711	pobj	scenario,with
R4303	T6714	T6710	cc	but,agree
R4304	T6715	T6710	conj	extend,agree
R4305	T6716	T6715	dobj	it,extend
R4306	T6717	T6710	punct	.,agree
R4307	T6719	T6720	advmod	Specifically,suffer
R4308	T6721	T6720	punct	", ",suffer
R4309	T6722	T6723	amod	efferent,fibers
R431	T962	T963	amod	vestibular,neurons
R4310	T6723	T6720	nsubj	fibers,suffer
R4311	T6724	T6720	aux	may,suffer
R4312	T6725	T6726	det	the,loss
R4313	T6726	T6720	dobj	loss,suffer
R4314	T6727	T6726	amod	same,loss
R4315	T6728	T6726	prep	of,loss
R4316	T6729	T6730	poss	their,support
R4317	T6730	T6728	pobj	support,of
R4318	T6731	T6732	advmod	molecularly,unknown
R4319	T6732	T6730	amod	unknown,support
R432	T963	T961	pobj	neurons,of
R4320	T6733	T6730	amod	neurotrophic,support
R4321	T6734	T6735	mark	as,do
R4322	T6735	T6720	advcl	do,suffer
R4323	T6736	T6735	nsubj	afferents,do
R4324	T6737	T6720	cc	and,suffer
R4325	T6738	T6739	advmod	therefore,show
R4326	T6739	T6720	conj	show,suffer
R4327	T6740	T6741	det	the,profile
R4328	T6741	T6739	dobj	profile,show
R4329	T6742	T6741	amod	same,profile
R433	T964	T960	cc	and,%
R4330	T6743	T6744	amod	spatio,temporal
R4331	T6744	T6741	amod	temporal,profile
R4332	T6745	T6744	punct	-,temporal
R4333	T6746	T6741	prep	of,profile
R4334	T6747	T6746	pobj	loss,of
R4335	T6748	T6749	punct	(,Fig.
R4336	T6749	T6739	parataxis	Fig.,show
R4337	T6750	T6749	nummod	3,Fig.
R4338	T6751	T6749	punct	),Fig.
R4339	T6752	T6720	punct	.,suffer
R434	T965	T966	advmod	only,29
R4340	T6754	T6755	advmod	Alternatively,sustain
R4341	T6756	T6755	punct	", ",sustain
R4342	T6757	T6758	amod	efferent,fibers
R4343	T6758	T6755	nsubj	fibers,sustain
R4344	T6759	T6755	aux	can,sustain
R4345	T6760	T6761	amod	established,connections
R4346	T6761	T6755	dobj	connections,sustain
R4347	T6762	T6763	advmod	only,long
R4348	T6763	T6755	advmod	long,sustain
R4349	T6764	T6763	advmod	as,long
R435	T966	T967	nummod	29,%
R4350	T6765	T6766	mark	as,are
R4351	T6766	T6763	advcl	are,long
R4352	T6767	T6768	amod	afferent,fibers
R4353	T6768	T6766	nsubj	fibers,are
R4354	T6769	T6766	acomp	present,are
R4355	T6770	T6755	punct	.,sustain
R4356	T6772	T6773	amod	More,information
R4357	T6773	T6774	nsubjpass	information,needed
R4358	T6775	T6773	prep	on,information
R4359	T6776	T6777	det	the,support
R436	T967	T960	conj	%,%
R4360	T6777	T6775	pobj	support,on
R4361	T6778	T6777	amod	actual,support
R4362	T6779	T6777	amod	molecular,support
R4363	T6780	T6777	prep	of,support
R4364	T6781	T6782	amod	efferent,fibers
R4365	T6782	T6780	pobj	fibers,of
R4366	T6783	T6777	prep	in,support
R4367	T6784	T6785	det	the,ear
R4368	T6785	T6783	pobj	ear,in
R4369	T6786	T6774	auxpass	is,needed
R437	T968	T967	prep	of,%
R4370	T6787	T6788	mark	before,distinguished
R4371	T6788	T6774	advcl	distinguished,needed
R4372	T6789	T6790	det	those,possibilities
R4373	T6790	T6788	nsubjpass	possibilities,distinguished
R4374	T6791	T6790	nummod	two,possibilities
R4375	T6792	T6788	aux	can,distinguished
R4376	T6793	T6788	auxpass	be,distinguished
R4377	T6794	T6774	punct	.,needed
R4378	T6796	T6797	det	The,onset
R4379	T6797	T6798	nsubjpass	onset,investigated
R438	T969	T970	amod	spiral,neurons
R4380	T6799	T6797	prep	of,onset
R4381	T6800	T6801	amod	cochleotopic,projections
R4382	T6801	T6799	pobj	projections,of
R4383	T6802	T6798	aux	has,investigated
R4384	T6803	T6798	auxpass	been,investigated
R4385	T6804	T6798	prep	in,investigated
R4386	T6805	T6804	pobj	detail,in
R4387	T6806	T6798	prep	in,investigated
R4388	T6807	T6808	advmod	only,mammals
R4389	T6808	T6806	pobj	mammals,in
R439	T970	T968	pobj	neurons,of
R4390	T6809	T6810	advmod	very,few
R4391	T6810	T6808	amod	few,mammals
R4392	T6811	T6812	punct	[,19
R4393	T6812	T6798	parataxis	19,investigated
R4394	T6813	T6812	punct	],19
R4395	T6814	T6798	punct	.,investigated
R4396	T6816	T6817	det	These,data
R4397	T6817	T6818	nsubj	data,suggest
R4398	T6819	T6820	mark	that,develops
R4399	T6820	T6818	ccomp	develops,suggest
R44	T238	T239	compound	hair,cells
R440	T971	T955	auxpass	are,lost
R4400	T6821	T6822	det	a,projection
R4401	T6822	T6820	nsubj	projection,develops
R4402	T6823	T6822	amod	cochleotopic,projection
R4403	T6824	T6820	prep	before,develops
R4404	T6825	T6824	pobj	onset,before
R4405	T6826	T6825	prep	of,onset
R4406	T6827	T6826	pobj	hearing,of
R4407	T6828	T6818	punct	.,suggest
R4408	T6830	T6831	poss	Our,data
R4409	T6831	T6832	nsubj	data,show
R441	T972	T944	punct	.,reported
R4410	T6833	T6834	mark	that,develops
R4411	T6834	T6832	ccomp	develops,show
R4412	T6835	T6836	advmod	at,least
R4413	T6836	T6834	advmod	least,develops
R4414	T6837	T6838	det	a,projection
R4415	T6838	T6834	nsubj	projection,develops
R4416	T6839	T6838	amod	cochleotopic,projection
R4417	T6840	T6838	prep	in,projection
R4418	T6841	T6842	det	the,nerve
R4419	T6842	T6840	pobj	nerve,in
R442	T974	T975	nsubjpass	It,suggested
R4420	T6843	T6842	amod	cochlear,nerve
R4421	T6844	T6842	cc	and,nerve
R4422	T6845	T6846	det	the,nuclei
R4423	T6846	T6842	conj	nuclei,nerve
R4424	T6847	T6846	amod	cochlear,nuclei
R4425	T6848	T6849	advmod	even,in
R4426	T6849	T6834	prep	in,develops
R4427	T6850	T6851	nmod	Brn,3c
R4428	T6851	T6852	nmod	3c,mutants
R4429	T6852	T6849	pobj	mutants,in
R443	T976	T975	auxpass	was,suggested
R4430	T6853	T6852	amod	null,mutants
R4431	T6854	T6855	punct	(,Fig.
R4432	T6855	T6832	parataxis	Fig.,show
R4433	T6856	T6855	nummod	6,Fig.
R4434	T6857	T6855	punct	),Fig.
R4435	T6858	T6832	punct	.,show
R4436	T6860	T6861	det	Those,data
R4437	T6861	T6862	nsubj	data,are
R4438	T6863	T6862	advmod	also,are
R4439	T6864	T6862	acomp	consistent,are
R444	T977	T978	mark	that,is
R4440	T6865	T6864	prep	with,consistent
R4441	T6866	T6867	det	the,formation
R4442	T6867	T6865	pobj	formation,with
R4443	T6868	T6867	prep	of,formation
R4444	T6869	T6870	det	a,projection
R4445	T6870	T6868	pobj	projection,of
R4446	T6871	T6870	amod	crude,projection
R4447	T6872	T6870	amod	cochleotopic,projection
R4448	T6873	T6867	prep	in,formation
R4449	T6874	T6875	nmod	NT,mutants
R445	T978	T975	ccomp	is,suggested
R4450	T6875	T6873	pobj	mutants,in
R4451	T6876	T6874	punct	-,NT
R4452	T6877	T6874	nummod	3,NT
R4453	T6878	T6875	amod	null,mutants
R4454	T6879	T6880	punct	[,14
R4455	T6880	T6862	parataxis	14,are
R4456	T6881	T6880	nummod	6,14
R4457	T6882	T6880	punct	",",14
R4458	T6883	T6880	punct	],14
R4459	T6884	T6862	punct	.,are
R446	T979	T978	expl	there,is
R4460	T6886	T6887	det	Those,mutants
R4461	T6887	T6888	nsubj	mutants,have
R4462	T6889	T6890	det	a,density
R4463	T6890	T6888	dobj	density,have
R4464	T6891	T6892	advmod	much,more
R4465	T6892	T6893	advmod	more,severely
R4466	T6893	T6894	advmod	severely,reduced
R4467	T6894	T6890	amod	reduced,density
R4468	T6895	T6890	prep	of,density
R4469	T6896	T6895	pobj	innervation,of
R447	T980	T978	advmod	possibly,is
R4470	T6897	T6890	prep	in,density
R4471	T6898	T6899	det	the,cochlea
R4472	T6899	T6897	pobj	cochlea,in
R4473	T6900	T6899	amod	developing,cochlea
R4474	T6901	T6902	punct	[,14
R4475	T6902	T6890	parataxis	14,density
R4476	T6903	T6902	nummod	6,14
R4477	T6904	T6902	punct	",",14
R4478	T6905	T6902	punct	],14
R4479	T6906	T6890	prep	than,density
R448	T981	T982	det	a,loss
R4480	T6907	T6908	det	the,reduction
R4481	T6908	T6906	pobj	reduction,than
R4482	T6909	T6910	nsubj	we,found
R4483	T6910	T6908	advcl	found,reduction
R4484	T6911	T6910	prep	in,found
R4485	T6912	T6913	nmod	Brn3c,mutants
R4486	T6913	T6911	pobj	mutants,in
R4487	T6914	T6913	amod	null,mutants
R4488	T6915	T6910	prep	at,found
R4489	T6916	T6915	pobj	P0,at
R449	T982	T978	attr	loss,is
R4490	T6917	T6888	punct	.,have
R4491	T6919	T6920	prep	In,be
R4492	T6921	T6922	det	this,context
R4493	T6922	T6919	pobj	context,In
R4494	T6923	T6920	punct	", ",be
R4495	T6924	T6920	nsubj	it,be
R4496	T6925	T6920	aux	would,be
R4497	T6926	T6920	acomp	interesting,be
R4498	T6927	T6928	aux	to,see
R4499	T6928	T6920	xcomp	see,be
R45	T239	T237	pobj	cells,of
R450	T983	T982	amod	complete,loss
R4500	T6929	T6930	mark	whether,perform
R4501	T6930	T6928	ccomp	perform,see
R4502	T6931	T6932	det	the,mouse
R4503	T6932	T6930	nsubj	mouse,perform
R4504	T6933	T6934	advmod	recently,generated
R4505	T6934	T6932	amod	generated,mouse
R4506	T6935	T6932	amod	transgenic,mouse
R4507	T6936	T6937	prep	in,expressed
R4508	T6937	T6932	relcl	expressed,mouse
R4509	T6938	T6936	pobj	which,in
R451	T984	T978	prep	in,is
R4510	T6939	T6937	nsubjpass	BDNF,expressed
R4511	T6940	T6937	auxpass	is,expressed
R4512	T6941	T6937	prep	under,expressed
R4513	T6942	T6943	nmod	NT,control
R4514	T6943	T6941	pobj	control,under
R4515	T6944	T6942	punct	-,NT
R4516	T6945	T6942	nummod	3,NT
R4517	T6946	T6943	compound	promoter,control
R4518	T6947	T6948	punct	[,33
R4519	T6948	T6932	parataxis	33,mouse
R452	T985	T984	pobj	adults,in
R4520	T6949	T6948	punct	],33
R4521	T6950	T6930	aux	could,perform
R4522	T6951	T6930	advmod	actually,perform
R4523	T6952	T6953	det	an,rescue
R4524	T6953	T6930	dobj	rescue,perform
R4525	T6954	T6955	advmod	even,more
R4526	T6955	T6956	advmod	more,pronounced
R4527	T6956	T6953	amod	pronounced,rescue
R4528	T6957	T6930	prep	in,perform
R4529	T6958	T6959	det	a,background
R453	T986	T987	punct	[,3
R4530	T6959	T6957	pobj	background,in
R4531	T6960	T6959	nmod	Brn3c,background
R4532	T6961	T6960	amod	null,Brn3c
R4533	T6962	T6960	amod	mutant,Brn3c
R4534	T6963	T6920	punct	.,be
R4535	T7066	T7065	prep	of,Relevance
R4536	T7067	T7068	poss	our,findings
R4537	T7068	T7066	pobj	findings,of
R4538	T7069	T7065	prep	to,Relevance
R4539	T7070	T7071	amod	other,mutations
R454	T987	T975	parataxis	3,suggested
R4540	T7071	T7069	pobj	mutations,to
R4541	T7072	T7071	prep	with,mutations
R4542	T7073	T7074	compound	hair,cell
R4543	T7074	T7075	compound	cell,loss
R4544	T7075	T7072	pobj	loss,with
R4545	T7077	T7078	nsubj	Vahava,demonstrated
R4546	T7079	T7080	advmod	et,al.
R4547	T7080	T7077	advmod	al.,Vahava
R4548	T7081	T7082	punct	[,12
R4549	T7082	T7077	parataxis	12,Vahava
R455	T988	T987	punct	],3
R4550	T7083	T7082	punct	],12
R4551	T7084	T7077	cc	and,Vahava
R4552	T7085	T7077	conj	Frydman,Vahava
R4553	T7086	T7087	advmod	et,al.
R4554	T7087	T7085	advmod	al.,Frydman
R4555	T7088	T7089	punct	[,34
R4556	T7089	T7085	parataxis	34,Frydman
R4557	T7090	T7089	punct	],34
R4558	T7091	T7078	aux	have,demonstrated
R4559	T7092	T7093	mark	that,results
R456	T989	T975	punct	.,suggested
R4560	T7093	T7078	ccomp	results,demonstrated
R4561	T7094	T7093	nsubj	mutation,results
R4562	T7095	T7094	prep	in,mutation
R4563	T7096	T7097	det	a,allele
R4564	T7097	T7095	pobj	allele,in
R4565	T7098	T7097	amod	single,allele
R4566	T7099	T7097	amod	human,allele
R4567	T7100	T7097	prep	of,allele
R4568	T7101	T7100	pobj	Pou4f3,of
R4569	T7102	T7097	punct	(,allele
R457	T991	T992	advmod	Other,exists
R4570	T7103	T7097	appos	Brn3c,allele
R4571	T7104	T7093	punct	),results
R4572	T7105	T7093	prep	in,results
R4573	T7106	T7107	det	a,onset
R4574	T7107	T7105	pobj	onset,in
R4575	T7108	T7107	amod	late,onset
R4576	T7109	T7107	prep	of,onset
R4577	T7110	T7111	amod	high,frequency
R4578	T7111	T7112	compound	frequency,loss
R4579	T7112	T7109	pobj	loss,of
R458	T993	T991	prep	than,Other
R4580	T7113	T7112	compound	hearing,loss
R4581	T7114	T7078	punct	.,demonstrated
R4582	T7116	T7117	advmod	Thus,far
R4583	T7117	T7118	advmod	far,are
R4584	T7119	T7120	det	no,data
R4585	T7120	T7118	nsubj	data,are
R4586	T7121	T7118	acomp	available,are
R4587	T7122	T7123	dep	that,correlate
R4588	T7123	T7118	ccomp	correlate,are
R4589	T7124	T7125	det	the,onset
R459	T994	T995	det	these,statements
R4590	T7125	T7123	dobj	onset,correlate
R4591	T7126	T7125	amod	late,onset
R4592	T7127	T7125	prep	of,onset
R4593	T7128	T7129	compound	hearing,loss
R4594	T7129	T7127	pobj	loss,of
R4595	T7130	T7123	prep	with,correlate
R4596	T7131	T7132	amod	morphological,defects
R4597	T7132	T7130	pobj	defects,with
R4598	T7133	T7132	prep	in,defects
R4599	T7134	T7135	det	the,cochlea
R46	T240	T236	aux	could,lead
R460	T995	T993	pobj	statements,than
R4600	T7135	T7133	pobj	cochlea,in
R4601	T7136	T7118	punct	.,are
R4602	T7138	T7139	prep	In,showed
R4603	T7140	T7138	pobj	fact,In
R4604	T7141	T7139	punct	", ",showed
R4605	T7142	T7143	det	an,investigation
R4606	T7143	T7139	nsubj	investigation,showed
R4607	T7144	T7143	prep	of,investigation
R4608	T7145	T7146	nmod	Brn3c,mice
R4609	T7146	T7144	pobj	mice,of
R461	T996	T995	amod	preliminary,statements
R4610	T7147	T7146	amod	heterozygotic,mice
R4611	T7148	T7149	det	no,effect
R4612	T7149	T7139	dobj	effect,showed
R4613	T7150	T7149	amod	additional,effect
R4614	T7151	T7149	prep	on,effect
R4615	T7152	T7153	compound	hearing,loss
R4616	T7153	T7151	pobj	loss,on
R4617	T7154	T7149	prep	due,effect
R4618	T7155	T7154	pcomp	to,due
R4619	T7156	T7154	pobj	haploinsufficiency,due
R462	T997	T992	punct	", ",exists
R4620	T7157	T7156	prep	in,haploinsufficiency
R4621	T7158	T7159	det	these,mice
R4622	T7159	T7157	pobj	mice,in
R4623	T7160	T7161	punct	[,35
R4624	T7161	T7139	parataxis	35,showed
R4625	T7162	T7161	punct	],35
R4626	T7163	T7139	punct	.,showed
R4627	T7165	T7166	poss	Our,data
R4628	T7166	T7167	nsubj	data,suggest
R4629	T7168	T7166	prep	on,data
R463	T998	T999	det	no,data
R4630	T7169	T7170	nmod	Brn3c,mutants
R4631	T7170	T7168	pobj	mutants,on
R4632	T7171	T7170	amod	null,mutants
R4633	T7172	T7170	compound	mouse,mutants
R4634	T7173	T7167	advmod	nevertheless,suggest
R4635	T7174	T7175	mark	that,correlate
R4636	T7175	T7167	ccomp	correlate,suggest
R4637	T7176	T7177	det	the,loss
R4638	T7177	T7175	nsubj	loss,correlate
R4639	T7178	T7179	amod	high,frequency
R464	T999	T992	nsubj	data,exists
R4640	T7179	T7177	nmod	frequency,loss
R4641	T7180	T7178	prep	to,high
R4642	T7181	T7180	amod	low,to
R4643	T7182	T7177	amod	progressive,loss
R4644	T7183	T7177	compound	hearing,loss
R4645	T7184	T7177	prep	in,loss
R4646	T7185	T7184	pobj	humans,in
R4647	T7186	T7175	aux	may,correlate
R4648	T7187	T7175	prep	with,correlate
R4649	T7188	T7189	det	the,factor
R465	T1000	T992	prep	concerning,exists
R4650	T7189	T7187	pobj	factor,with
R4651	T7190	T7189	amod	unknown,factor
R4652	T7191	T7189	punct	(,factor
R4653	T7192	T7189	nmod	s,factor
R4654	T7193	T7189	punct	),factor
R4655	T7194	T7195	dep	that,mediate
R4656	T7195	T7189	relcl	mediate,factor
R4657	T7196	T7197	amod	apical,neuron
R4658	T7197	T7199	compound	neuron,survival
R4659	T7198	T7197	amod	spiral,neuron
R466	T1001	T1002	det	the,pattern
R4660	T7199	T7195	dobj	survival,mediate
R4661	T7200	T7195	prep	into,mediate
R4662	T7201	T7200	pobj	adulthood,into
R4663	T7202	T7167	punct	.,suggest
R4664	T7204	T7205	amod	Quantitative,data
R4665	T7205	T7206	nsubjpass	data,needed
R4666	T7207	T7205	prep	on,data
R4667	T7208	T7209	amod	human,cochleae
R4668	T7209	T7207	pobj	cochleae,on
R4669	T7210	T7209	compound	Pou4f3,cochleae
R467	T1002	T1000	pobj	pattern,concerning
R4670	T7211	T7206	auxpass	is,needed
R4671	T7212	T7213	aux	to,verify
R4672	T7213	T7206	advcl	verify,needed
R4673	T7214	T7215	mark	that,is
R4674	T7215	T7213	ccomp	is,verify
R4675	T7216	T7217	amod	spiral,neuron
R4676	T7217	T7218	compound	neuron,loss
R4677	T7218	T7215	nsubj	loss,is
R4678	T7219	T7220	advmod	more,pronounced
R4679	T7220	T7215	acomp	pronounced,is
R468	T1003	T1002	amod	detailed,pattern
R4680	T7221	T7215	prep	in,is
R4681	T7222	T7223	det	the,area
R4682	T7223	T7221	pobj	area,in
R4683	T7224	T7223	amod	basal,area
R4684	T7225	T7223	punct	", ",area
R4685	T7226	T7227	amod	high,frequency
R4686	T7227	T7223	compound	frequency,area
R4687	T7228	T7223	prep	of,area
R4688	T7229	T7230	det	these,patients
R4689	T7230	T7228	pobj	patients,of
R469	T1004	T1002	prep	of,pattern
R4690	T7231	T7232	npadvmod	hearing,deficient
R4691	T7232	T7230	amod	deficient,patients
R4692	T7233	T7232	punct	-,deficient
R4693	T7234	T7206	punct	.,needed
R4694	T7236	T7237	amod	Similar,data
R4695	T7237	T7238	nsubjpass	data,needed
R4696	T7239	T7238	auxpass	are,needed
R4697	T7240	T7238	advmod	also,needed
R4698	T7241	T7238	prep	for,needed
R4699	T7242	T7243	amod	other,children
R47	T241	T236	prep	to,lead
R470	T1005	T1004	pobj	loss,of
R4700	T7243	T7241	pobj	children,for
R4701	T7244	T7245	advmod	congenitally,deaf
R4702	T7245	T7243	amod	deaf,children
R4703	T7246	T7247	punct	[,36
R4704	T7247	T7241	parataxis	36,for
R4705	T7248	T7247	punct	],36
R4706	T7249	T7241	cc	and,for
R4707	T7250	T7241	conj	in,for
R4708	T7251	T7252	det	the,cat
R4709	T7252	T7250	pobj	cat,in
R471	T1006	T1005	prep	of,loss
R4710	T7253	T7252	nmod	deaf,cat
R4711	T7254	T7252	amod	white,cat
R4712	T7255	T7256	punct	[,25
R4713	T7256	T7250	parataxis	25,in
R4714	T7257	T7256	punct	],25
R4715	T7258	T7238	punct	.,needed
R4716	T7260	T7261	amod	Further,work
R4717	T7261	T7262	nsubj	work,help
R4718	T7263	T7261	prep	on,work
R4719	T7264	T7265	det	the,mice
R472	T1007	T1006	pobj	innervation,of
R4720	T7265	T7263	pobj	mice,on
R4721	T7266	T7267	advmod	recently,available
R4722	T7267	T7265	amod	available,mice
R4723	T7268	T7265	amod	mutant,mice
R4724	T7269	T7265	prep	with,mice
R4725	T7270	T7271	amod	specific,absence
R4726	T7271	T7269	pobj	absence,with
R4727	T7272	T7271	prep	of,absence
R4728	T7273	T7274	det	all,cells
R4729	T7274	T7272	pobj	cells,of
R473	T1008	T1005	prep	in,loss
R4730	T7275	T7274	compound	hair,cells
R4731	T7276	T7277	punct	[,37
R4732	T7277	T7274	parataxis	37,cells
R4733	T7278	T7277	punct	],37
R4734	T7279	T7274	punct	", ",cells
R4735	T7280	T7281	amod	outer,cells
R4736	T7281	T7274	appos	cells,cells
R4737	T7282	T7281	compound	hair,cells
R4738	T7283	T7281	prep	in,cells
R4739	T7284	T7285	det	the,base
R474	T1009	T1010	npadvmod	Brn3c,null
R4740	T7285	T7283	pobj	base,in
R4741	T7286	T7287	punct	[,38
R4742	T7287	T7285	parataxis	38,base
R4743	T7288	T7287	punct	],38
R4744	T7289	T7285	cc	or,base
R4745	T7290	T7285	conj	apex,base
R4746	T7291	T7292	punct	[,39
R4747	T7292	T7290	parataxis	39,apex
R4748	T7293	T7292	punct	],39
R4749	T7294	T7262	aux	could,help
R475	T1010	T1011	amod	null,mutants
R4750	T7295	T7262	advmod	further,help
R4751	T7296	T7297	aux	to,clarify
R4752	T7297	T7262	xcomp	clarify,help
R4753	T7298	T7299	det	the,role
R4754	T7299	T7297	dobj	role,clarify
R4755	T7300	T7299	prep	of,role
R4756	T7301	T7302	compound	hair,cells
R4757	T7302	T7300	pobj	cells,of
R4758	T7303	T7299	prep	in,role
R4759	T7304	T7303	pcomp	forming,in
R476	T1011	T1008	pobj	mutants,in
R4760	T7305	T7304	cc	and,forming
R4761	T7306	T7304	conj	maintaining,forming
R4762	T7307	T7308	amod	afferent,innervation
R4763	T7308	T7306	dobj	innervation,maintaining
R4764	T7309	T7307	cc	and,afferent
R4765	T7310	T7307	conj	efferent,afferent
R4766	T7311	T7299	prep	in,role
R4767	T7312	T7313	det	these,mice
R4768	T7313	T7311	pobj	mice,in
R4769	T7314	T7313	compound	model,mice
R477	T1012	T992	punct	.,exists
R4770	T7315	T7262	punct	.,help
R4775	T7403	T7404	det	The,loss
R4776	T7404	T7406	nsubj	loss,shows
R4777	T7405	T7404	amod	progressive,loss
R4778	T7407	T7404	prep	of,loss
R4779	T7408	T7409	amod	afferent,innervation
R478	T1014	T1015	det	The,development
R4780	T7409	T7407	pobj	innervation,of
R4781	T7410	T7408	cc	and,afferent
R4782	T7411	T7408	conj	efferent,afferent
R4783	T7412	T7404	prep	in,loss
R4784	T7413	T7414	npadvmod	Brn3c,null
R4785	T7414	T7415	amod	null,mutants
R4786	T7415	T7412	pobj	mutants,in
R4787	T7416	T7417	preconj	neither,in
R4788	T7417	T7406	prep	in,shows
R4789	T7418	T7417	pobj	spatial,in
R479	T1015	T1017	nsubj	development,lead
R4790	T7419	T7417	cc	nor,in
R4791	T7420	T7417	conj	in,in
R4792	T7421	T7420	pobj	temporal,in
R4793	T7422	T7420	pobj	pattern,in
R4794	T7423	T7424	det	a,resemblance
R4795	T7424	T7406	dobj	resemblance,shows
R4796	T7425	T7424	prep	to,resemblance
R4797	T7426	T7425	pobj	losses,to
R4798	T7427	T7426	acl	reported,losses
R4799	T7428	T7427	prep	in,reported
R48	T242	T243	amod	enough,expression
R480	T1016	T1015	amod	initial,development
R4800	T7429	T7430	amod	simple,BDNF
R4801	T7430	T7428	pobj	BDNF,in
R4802	T7431	T7430	cc	or,BDNF
R4803	T7432	T7433	nmod	NT,mutations
R4804	T7433	T7430	conj	mutations,BDNF
R4805	T7434	T7432	punct	-,NT
R4806	T7435	T7432	nummod	3,NT
R4807	T7436	T7433	amod	null,mutations
R4808	T7437	T7438	punct	[,6
R4809	T7438	T7406	parataxis	6,shows
R481	T1018	T1015	cc	and,development
R4810	T7439	T7438	punct	],6
R4811	T7440	T7406	punct	.,shows
R4812	T7442	T7443	amod	Null,mutants
R4813	T7443	T7444	nsubj	mutants,completed
R4814	T7445	T7443	prep	of,mutants
R4815	T7446	T7447	npadvmod	ear,specific
R4816	T7447	T7448	amod	specific,neurotrophins
R4817	T7448	T7445	pobj	neurotrophins,of
R4818	T7449	T7444	aux	have,completed
R4819	T7450	T7451	det	the,loss
R482	T1019	T1020	amod	partial,differentiation
R4820	T7451	T7444	dobj	loss,completed
R4821	T7452	T7451	prep	of,loss
R4822	T7453	T7454	amod	sensory,neurons
R4823	T7454	T7452	pobj	neurons,of
R4824	T7455	T7444	prep	before,completed
R4825	T7456	T7455	pobj	birth,before
R4826	T7457	T7444	punct	.,completed
R4827	T7459	T7460	prep	In,suggest
R4828	T7461	T7459	pobj	contrast,In
R4829	T7462	T7460	punct	", ",suggest
R483	T1020	T1015	conj	differentiation,development
R4830	T7463	T7464	poss	our,results
R4831	T7464	T7460	nsubj	results,suggest
R4832	T7465	T7466	det	a,loss
R4833	T7466	T7460	dobj	loss,suggest
R4834	T7467	T7466	amod	slow,loss
R4835	T7468	T7466	prep	of,loss
R4836	T7469	T7470	amod	afferent,innervation
R4837	T7470	T7468	pobj	innervation,of
R4838	T7471	T7469	cc	and,afferent
R4839	T7472	T7469	conj	efferent,afferent
R484	T1021	T1015	prep	of,development
R4840	T7473	T7466	prep	between,loss
R4841	T7474	T7473	pobj	P0,between
R4842	T7475	T7474	cc	and,P0
R4843	T7476	T7477	advmod	at,least
R4844	T7477	T7478	advmod	least,months
R4845	T7478	T7474	conj	months,P0
R4846	T7479	T7478	nummod	6,months
R4847	T7480	T7460	punct	.,suggest
R4848	T7482	T7483	det	This,loss
R4849	T7483	T7487	nsubj	loss,is
R485	T1022	T1023	compound	hair,cells
R4850	T7484	T7483	amod	late,loss
R4851	T7485	T7486	amod	sensory,neuron
R4852	T7486	T7483	compound	neuron,loss
R4853	T7488	T7487	advmod	likely,is
R4854	T7489	T7487	neg	not,is
R4855	T7490	T7487	acomp	related,is
R4856	T7491	T7490	prep	to,related
R4857	T7492	T7493	amod	known,signaling
R4858	T7493	T7491	pobj	signaling,to
R4859	T7494	T7493	compound	neurotrophin,signaling
R486	T1023	T1021	pobj	cells,of
R4860	T7495	T7496	dep	which,becomes
R4861	T7496	T7493	relcl	becomes,signaling
R4862	T7497	T7496	acomp	reduced,becomes
R4863	T7498	T7496	prep	in,becomes
R4864	T7499	T7500	amod	neonatal,animals
R4865	T7500	T7498	pobj	animals,in
R4866	T7501	T7500	amod	wildtype,animals
R4867	T7502	T7487	punct	.,is
R4868	T7504	T7505	amod	Other,factors
R4869	T7505	T7506	nsubj	factors,need
R487	T1024	T1015	prep	in,development
R4870	T7507	T7505	punct	", ",factors
R4871	T7508	T7509	amod	such,as
R4872	T7509	T7505	prep	as,factors
R4873	T7510	T7509	pobj	GDNF,as
R4874	T7511	T7512	punct	[,40
R4875	T7512	T7505	parataxis	40,factors
R4876	T7513	T7512	nummod	11,40
R4877	T7514	T7512	punct	",",40
R4878	T7515	T7512	punct	],40
R4879	T7516	T7517	aux	to,investigated
R488	T1025	T1026	compound	Brn3c,mutants
R4880	T7517	T7506	xcomp	investigated,need
R4881	T7518	T7517	auxpass	be,investigated
R4882	T7519	T7517	prep	in,investigated
R4883	T7520	T7521	poss	their,expression
R4884	T7521	T7519	pobj	expression,in
R4885	T7522	T7517	prep	in,investigated
R4886	T7523	T7524	det	these,mutants
R4887	T7524	T7522	pobj	mutants,in
R4888	T7525	T7506	cc	and,need
R4889	T7526	T7527	poss	their,role
R489	T1026	T1024	pobj	mutants,in
R4890	T7527	T7529	nsubj	role,needs
R4891	T7528	T7527	amod	functional,role
R4892	T7529	T7506	conj	needs,need
R4893	T7530	T7531	aux	to,assessed
R4894	T7531	T7529	xcomp	assessed,needs
R4895	T7532	T7531	auxpass	be,assessed
R4896	T7533	T7531	punct	", ",assessed
R4897	T7534	T7535	prep	in,in
R4898	T7535	T7531	prep	in,assessed
R4899	T7536	T7534	amod	particular,in
R49	T243	T241	pobj	expression,to
R490	T1027	T1017	aux	could,lead
R4900	T7537	T7538	det	the,apex
R4901	T7538	T7535	pobj	apex,in
R4902	T7539	T7538	amod	cochlear,apex
R4903	T7540	T7529	punct	.,needs
R4904	T7542	T7543	det	The,retention
R4905	T7543	T7546	nsubj	retention,raises
R4906	T7544	T7545	amod	long,term
R4907	T7545	T7543	compound	term,retention
R4908	T7547	T7543	prep	of,retention
R4909	T7548	T7547	pobj	afferents,of
R491	T1028	T1017	advmod	possibly,lead
R4910	T7549	T7543	prep	in,retention
R4911	T7550	T7551	det	the,apex
R4912	T7551	T7549	pobj	apex,in
R4913	T7552	T7551	amod	cochlear,apex
R4914	T7553	T7543	prep	in,retention
R4915	T7554	T7555	det	the,absence
R4916	T7555	T7553	pobj	absence,in
R4917	T7556	T7555	prep	of,absence
R4918	T7557	T7558	det	any,differentiation
R4919	T7558	T7556	pobj	differentiation,of
R492	T1029	T1017	prep	to,lead
R4920	T7559	T7558	amod	apparent,differentiation
R4921	T7560	T7558	prep	of,differentiation
R4922	T7561	T7562	compound	hair,cells
R4923	T7562	T7560	pobj	cells,of
R4924	T7563	T7546	dobj	hopes,raises
R4925	T7564	T7563	prep	for,hopes
R4926	T7565	T7566	amod	cochlear,implants
R4927	T7566	T7564	pobj	implants,for
R4928	T7567	T7566	prep	in,implants
R4929	T7568	T7569	amod	deaf,born
R493	T1030	T1031	det	some,expression
R4930	T7569	T7571	amod	born,children
R4931	T7570	T7569	punct	-,born
R4932	T7571	T7567	pobj	children,in
R4933	T7572	T7546	punct	.,raises
R4934	T7574	T7575	amod	Similar,retention
R4935	T7575	T7578	nsubj	retention,exists
R4936	T7576	T7577	amod	long,term
R4937	T7577	T7575	compound	term,retention
R4938	T7579	T7575	prep	of,retention
R4939	T7580	T7581	amod	apical,afferents
R494	T1031	T1029	pobj	expression,to
R4940	T7581	T7579	pobj	afferents,of
R4941	T7582	T7578	prep	in,exists
R4942	T7583	T7584	det	the,cat
R4943	T7584	T7582	pobj	cat,in
R4944	T7585	T7584	nmod	deaf,cat
R4945	T7586	T7584	amod	white,cat
R4946	T7587	T7588	punct	[,25
R4947	T7588	T7578	parataxis	25,exists
R4948	T7589	T7588	punct	],25
R4949	T7590	T7578	cc	and,exists
R495	T1032	T1031	compound	neurotrophin,expression
R4950	T7591	T7592	aux	should,explored
R4951	T7592	T7578	conj	explored,exists
R4952	T7593	T7592	auxpass	be,explored
R4953	T7594	T7592	prep	in,explored
R4954	T7595	T7596	amod	other,systems
R4955	T7596	T7594	pobj	systems,in
R4956	T7597	T7596	compound	model,systems
R4957	T7598	T7596	prep	with,systems
R4958	T7599	T7600	amod	embryonic,loss
R4959	T7600	T7598	pobj	loss,with
R496	T1033	T1031	prep	in,expression
R4960	T7601	T7599	cc	and,embryonic
R4961	T7602	T7599	conj	neonatal,embryonic
R4962	T7603	T7604	compound	hair,cell
R4963	T7604	T7600	compound	cell,loss
R4964	T7605	T7606	punct	[,38
R4965	T7606	T7592	parataxis	38,explored
R4966	T7607	T7606	nummod	37,38
R4967	T7608	T7606	punct	",",38
R4968	T7609	T7606	punct	],38
R4969	T7610	T7578	punct	.,exists
R497	T1034	T1035	det	these,cells
R4970	T7650	T7649	cc	and,Breeding
R4971	T7651	T7649	conj	genotyping,Breeding
R4972	T7653	T7654	compound	Brn3c,mice
R4973	T7654	T7655	nsubjpass	mice,bred
R4974	T7656	T7655	auxpass	were,bred
R4975	T7657	T7658	mark	as,described
R4976	T7658	T7655	advcl	described,bred
R4977	T7659	T7658	advmod	previously,described
R4978	T7660	T7661	punct	[,22
R4979	T7661	T7655	parataxis	22,bred
R498	T1035	T1033	pobj	cells,in
R4980	T7662	T7661	punct	],22
R4981	T7663	T7655	punct	.,bred
R4982	T7665	T7666	nsubjpass	Mice,genotyped
R4983	T7667	T7666	auxpass	were,genotyped
R4984	T7668	T7666	cc	and,genotyped
R4985	T7669	T7670	nmod	Brn3c,mutants
R4986	T7670	T7672	nsubjpass	mutants,raised
R4987	T7671	T7670	amod	null,mutants
R4988	T7672	T7666	conj	raised,genotyped
R4989	T7673	T7672	auxpass	were,raised
R499	T1036	T1037	aux	to,sustain
R4990	T7674	T7672	prep	to,raised
R4991	T7675	T7676	det	a,age
R4992	T7676	T7674	pobj	age,to
R4993	T7677	T7676	amod	specific,age
R4994	T7678	T7679	punct	(,2
R4995	T7679	T7676	parataxis	2,age
R4996	T7680	T7681	dep	P0,8
R4997	T7681	T7679	dep	8,2
R4998	T7682	T7681	punct	", ",8
R4999	T7683	T7681	nsubj	N,8
R5	T191	T190	amod	mutant,mice
R50	T244	T243	compound	neurotrophin,expression
R500	T1037	T1017	advcl	sustain,lead
R5000	T7684	T7681	punct	=,8
R5001	T7685	T7679	punct	;,2
R5002	T7686	T7687	dep	P7,6
R5003	T7687	T7679	dep	6,2
R5004	T7688	T7687	punct	", ",6
R5005	T7689	T7687	nsubj	N,6
R5006	T7690	T7687	punct	=,6
R5007	T7691	T7679	punct	;,2
R5008	T7692	T7693	dep	P8,6
R5009	T7693	T7679	dep	6,2
R501	T1038	T1039	amod	sensory,neurons
R5010	T7694	T7693	punct	", ",6
R5011	T7695	T7693	nsubj	N,6
R5012	T7696	T7693	punct	=,6
R5013	T7697	T7679	punct	;,2
R5014	T7698	T7699	nummod	6,months
R5015	T7699	T7700	npadvmod	months,old
R5016	T7700	T7679	amod	old,2
R5017	T7701	T7679	punct	", ",2
R5018	T7702	T7679	nsubj	N,2
R5019	T7703	T7679	punct	=,2
R502	T1039	T1037	dobj	neurons,sustain
R5020	T7704	T7679	punct	),2
R5021	T7705	T7672	punct	.,raised
R5022	T7707	T7708	det	The,animals
R5023	T7708	T7709	nsubjpass	animals,anesthetized
R5024	T7710	T7709	auxpass	were,anesthetized
R5025	T7711	T7709	advmod	deeply,anesthetized
R5026	T7712	T7709	prep	with,anesthetized
R5027	T7713	T7712	pobj	pentobarbital,with
R5028	T7714	T7709	cc	and,anesthetized
R5029	T7715	T7716	advmod	transcardially,perfused
R503	T1040	T1037	prep	through,sustain
R5030	T7716	T7709	conj	perfused,anesthetized
R5031	T7717	T7716	prep	with,perfused
R5032	T7718	T7719	nummod	4,%
R5033	T7719	T7720	compound	%,paraformaldehyde
R5034	T7720	T7717	pobj	paraformaldehyde,with
R5035	T7721	T7720	prep	in,paraformaldehyde
R5036	T7722	T7723	nummod	0.1,M
R5037	T7723	T7724	compound	M,buffer
R5038	T7724	T7721	pobj	buffer,in
R5039	T7725	T7724	compound	phosphate,buffer
R504	T1041	T1042	amod	embryonic,development
R5040	T7726	T7727	punct	(,pH
R5041	T7727	T7720	parataxis	pH,paraformaldehyde
R5042	T7728	T7727	nummod	7.4,pH
R5043	T7729	T7727	punct	),pH
R5044	T7730	T7709	punct	.,anesthetized
R5045	T7732	T7733	nsubjpass	Ears,postfixed
R5046	T7734	T7733	auxpass	were,postfixed
R5047	T7735	T7733	prep	in,postfixed
R5048	T7736	T7737	det	the,fixative
R5049	T7737	T7735	pobj	fixative,in
R505	T1042	T1040	pobj	development,through
R5050	T7738	T7737	amod	same,fixative
R5051	T7739	T7733	prep	for,postfixed
R5052	T7740	T7741	advmod	at,one
R5053	T7741	T7743	nummod	one,day
R5054	T7742	T7741	advmod	least,one
R5055	T7743	T7739	pobj	day,for
R5056	T7744	T7745	amod	prior,to
R5057	T7745	T7733	prep	to,postfixed
R5058	T7746	T7745	pobj	dissection,to
R5059	T7747	T7733	punct	.,postfixed
R506	T1043	T1040	cc	and,through
R5060	T7828	T7827	prep	of,Tracing
R5061	T7829	T7830	compound	nerve,fibers
R5062	T7830	T7828	pobj	fibers,of
R5063	T7832	T7833	nsubjpass	DiI,performed
R5064	T7834	T7832	amod	tracing,DiI
R5065	T7835	T7832	prep	from,DiI
R5066	T7836	T7837	det	the,brainstem
R5067	T7837	T7835	pobj	brainstem,from
R5068	T7838	T7833	auxpass	was,performed
R5069	T7839	T7840	mark	as,described
R507	T1044	T1040	conj	beyond,through
R5070	T7840	T7833	advcl	described,performed
R5071	T7841	T7840	advmod	previously,described
R5072	T7842	T7843	punct	[,41
R5073	T7843	T7833	parataxis	41,performed
R5074	T7844	T7843	punct	],41
R5075	T7845	T7833	punct	.,performed
R5076	T7847	T7848	amod	Small,stripes
R5077	T7848	T7850	nsubjpass	stripes,implanted
R5078	T7849	T7848	compound	filter,stripes
R5079	T7851	T7848	acl	soaked,stripes
R508	T1045	T1017	punct	.,lead
R5080	T7852	T7851	prep	with,soaked
R5081	T7853	T7854	amod	saturated,DiI
R5082	T7854	T7852	pobj	DiI,with
R5083	T7855	T7850	auxpass	were,implanted
R5084	T7856	T7850	prep	into,implanted
R5085	T7857	T7858	det	the,bundle
R5086	T7858	T7856	pobj	bundle,into
R5087	T7859	T7858	amod	efferent,bundle
R5088	T7860	T7858	compound	fiber,bundle
R5089	T7861	T7858	prep	near,bundle
R509	T1047	T1048	nsubj	Data,shown
R5090	T7862	T7863	det	the,plate
R5091	T7863	T7861	pobj	plate,near
R5092	T7864	T7863	compound	floor,plate
R5093	T7865	T7856	cc	or,into
R5094	T7866	T7856	conj	into,into
R5095	T7867	T7868	det	the,afferents
R5096	T7868	T7866	pobj	afferents,into
R5097	T7869	T7868	amod	ascending,afferents
R5098	T7870	T7869	cc	or,ascending
R5099	T7871	T7869	conj	descending,ascending
R51	T245	T246	aux	to,sustain
R510	T1049	T1047	prep	on,Data
R5100	T7872	T7868	prep	in,afferents
R5101	T7873	T7874	det	the,plate
R5102	T7874	T7872	pobj	plate,in
R5103	T7875	T7874	amod	alar,plate
R5104	T7876	T7877	punct	[,42
R5105	T7877	T7850	parataxis	42,implanted
R5106	T7878	T7877	punct	],42
R5107	T7879	T7850	punct	.,implanted
R5108	T7881	T7882	prep	After,dissected
R5109	T7883	T7884	amod	appropriate,time
R511	T1050	T1051	amod	various,mutants
R5110	T7884	T7881	pobj	time,After
R5111	T7885	T7884	compound	diffusion,time
R5112	T7886	T7884	prep	of,time
R5113	T7887	T7888	det	the,dye
R5114	T7888	T7886	pobj	dye,of
R5115	T7889	T7882	punct	", ",dissected
R5116	T7890	T7891	det	the,ears
R5117	T7891	T7882	nsubjpass	ears,dissected
R5118	T7892	T7882	auxpass	were,dissected
R5119	T7893	T7882	cc	and,dissected
R512	T1051	T1049	pobj	mutants,on
R5120	T7894	T7882	conj	mounted,dissected
R5121	T7895	T7894	advcl	flat,mounted
R5122	T7896	T7894	prep	for,mounted
R5123	T7897	T7896	pobj	visualization,for
R5124	T7898	T7894	prep	in,mounted
R5125	T7899	T7900	det	an,microscope
R5126	T7900	T7898	pobj	microscope,in
R5127	T7901	T7900	amod	epifluorescent,microscope
R5128	T7902	T7882	punct	.,dissected
R5129	T7904	T7905	nsubj	Images,taken
R513	T1052	T1053	amod	single,neurotrophin
R5130	T7906	T7905	aux	were,taken
R5131	T7907	T7905	prep	on,taken
R5132	T7908	T7909	amod	black,film
R5133	T7909	T7907	pobj	film,on
R5134	T7910	T7908	cc	and,black
R5135	T7911	T7908	conj	white,black
R5136	T7912	T7905	cc	or,taken
R5137	T7913	T7905	conj	acquired,taken
R5138	T7914	T7913	prep	with,acquired
R5139	T7915	T7916	det	a,camera
R514	T1053	T1056	npadvmod	neurotrophin,null
R5140	T7916	T7914	pobj	camera,with
R5141	T7917	T7916	amod	cooled,camera
R5142	T7918	T7916	compound	CCD,camera
R5143	T7919	T7905	cc	and,taken
R5144	T7920	T7905	conj	processed,taken
R5145	T7921	T7920	advcl	using,processed
R5146	T7922	T7923	compound	ImagePro,software
R5147	T7923	T7921	dobj	software,using
R5148	T7924	T7925	punct	(,Cybernetics
R5149	T7925	T7923	parataxis	Cybernetics,software
R515	T1054	T1052	cc	and,single
R5150	T7926	T7925	compound	Media,Cybernetics
R5151	T7927	T7925	punct	),Cybernetics
R5152	T7928	T7905	punct	.,taken
R5153	T7930	T7931	nsubjpass	Ears,reacted
R5154	T7932	T7931	auxpass	were,reacted
R5155	T7933	T7931	advmod	subsequently,reacted
R5156	T7934	T7931	prep	for,reacted
R5157	T7935	T7936	amod	acetylated,tubulin
R5158	T7936	T7934	pobj	tubulin,for
R5159	T7937	T7938	aux	to,reveal
R516	T1055	T1052	conj	compound,single
R5160	T7938	T7931	advcl	reveal,reacted
R5161	T7939	T7940	det	the,pattern
R5162	T7940	T7938	dobj	pattern,reveal
R5163	T7941	T7940	prep	of,pattern
R5164	T7942	T7941	pobj	innervation,of
R5165	T7943	T7938	prep	in,reveal
R5166	T7944	T7943	pobj	addition,in
R5167	T7945	T7944	prep	to,addition
R5168	T7946	T7947	det	the,DiI
R5169	T7947	T7945	pobj	DiI,to
R517	T1056	T1051	amod	null,mutants
R5170	T7948	T7947	amod	tracing,DiI
R5171	T7949	T7947	prep	with,DiI
R5172	T7950	T7951	det	a,technique
R5173	T7951	T7949	pobj	technique,with
R5174	T7952	T7951	amod	different,technique
R5175	T7953	T7954	mark	as,described
R5176	T7954	T7947	advcl	described,DiI
R5177	T7955	T7954	advmod	previously,described
R5178	T7956	T7957	punct	[,14
R5179	T7957	T7931	parataxis	14,reacted
R518	T1057	T1048	aux	have,shown
R5180	T7958	T7957	punct	],14
R5181	T7959	T7931	punct	.,reacted
R5182	T7961	T7962	advmod	Briefly,incubated
R5183	T7963	T7962	punct	", ",incubated
R5184	T7964	T7965	amod	dissected,ears
R5185	T7965	T7962	nsubjpass	ears,incubated
R5186	T7966	T7962	auxpass	were,incubated
R5187	T7967	T7962	prep	with,incubated
R5188	T7968	T7969	quantmod	1,500
R5189	T7969	T7971	nummod	500,antibodies
R519	T1058	T1059	mark	that,leads
R5190	T7970	T7969	punct	:,500
R5191	T7971	T7967	pobj	antibodies,with
R5192	T7972	T7971	amod	anti-acetylated,antibodies
R5193	T7973	T7971	compound	tubulin,antibodies
R5194	T7974	T7975	punct	(,Sigma
R5195	T7975	T7971	parataxis	Sigma,antibodies
R5196	T7976	T7975	punct	", ",Sigma
R5197	T7977	T7978	compound	St.,Louis
R5198	T7978	T7975	npadvmod	Louis,Sigma
R5199	T7979	T7975	punct	),Sigma
R52	T246	T243	acl	sustain,expression
R520	T1059	T1048	ccomp	leads,shown
R5200	T7980	T7962	advcl	followed,incubated
R5201	T7981	T7980	agent	by,followed
R5202	T7982	T7983	amod	secondary,antibodies
R5203	T7983	T7981	pobj	antibodies,by
R5204	T7984	T7983	acl	conjugated,antibodies
R5205	T7985	T7984	prep	to,conjugated
R5206	T7986	T7985	pobj	HRP,to
R5207	T7987	T7962	punct	.,incubated
R5208	T7989	T7990	amod	Dissected,ears
R5209	T7990	T7992	nsubjpass	ears,reacted
R521	T1060	T1061	det	the,loss
R5210	T7991	T7990	amod	inner,ears
R5211	T7993	T7992	auxpass	were,reacted
R5212	T7994	T7992	prep	with,reacted
R5213	T7995	T7994	pobj	DAB,with
R5214	T7996	T7995	cc	and,DAB
R5215	T7997	T7995	conj	H2O2,DAB
R5216	T7998	T7992	prep	for,reacted
R5217	T7999	T8000	compound	HRP,distribution
R5218	T8000	T7998	pobj	distribution,for
R5219	T8001	T7992	cc	and,reacted
R522	T1061	T1059	nsubj	loss,leads
R5220	T8002	T8003	advmod	subsequently,viewed
R5221	T8003	T7992	conj	viewed,reacted
R5222	T8004	T8003	prep	as,viewed
R5223	T8005	T8006	amod	whole,mounts
R5224	T8006	T8004	pobj	mounts,as
R5225	T8007	T7992	punct	.,reacted
R5226	T8009	T8010	prep	After,embedded
R5227	T8011	T8009	pcomp	photographing,After
R5228	T8012	T8011	prep	as,photographing
R5229	T8013	T8014	amod	whole,mounts
R523	T1062	T1061	prep	of,loss
R5230	T8014	T8012	pobj	mounts,as
R5231	T8015	T8010	punct	", ",embedded
R5232	T8016	T8017	det	the,ears
R5233	T8017	T8010	nsubjpass	ears,embedded
R5234	T8018	T8010	auxpass	were,embedded
R5235	T8019	T8010	prep	in,embedded
R5236	T8020	T8021	compound	epoxy,resin
R5237	T8021	T8019	pobj	resin,in
R5238	T8022	T8010	cc	and,embedded
R5239	T8023	T8010	conj	sectioned,embedded
R524	T1063	T1064	det	a,neurotrophin
R5240	T8024	T8025	aux	to,reveal
R5241	T8025	T8023	advcl	reveal,sectioned
R5242	T8026	T8027	det	the,distribution
R5243	T8027	T8025	dobj	distribution,reveal
R5244	T8028	T8027	prep	of,distribution
R5245	T8029	T8028	pobj	fibers,of
R5246	T8030	T8027	prep	inside,distribution
R5247	T8031	T8032	det	the,epithelia
R5248	T8032	T8030	pobj	epithelia,inside
R5249	T8033	T8032	amod	sensory,epithelia
R525	T1064	T1062	pobj	neurotrophin,of
R5250	T8034	T8025	prep	in,reveal
R5251	T8035	T8036	amod	more,detail
R5252	T8036	T8034	pobj	detail,in
R5253	T8037	T8010	punct	.,embedded
R5254	T8039	T8040	amod	Cochleotopic,projection
R5255	T8040	T8041	nsubjpass	projection,evaluated
R5256	T8042	T8041	auxpass	was,evaluated
R5257	T8043	T8041	prep	by,evaluated
R5258	T8044	T8043	pcomp	inserting,by
R5259	T8045	T8046	npadvmod	DiI,soaked
R526	T1065	T1064	amod	specific,neurotrophin
R5260	T8046	T8047	amod	soaked,strips
R5261	T8047	T8044	dobj	strips,inserting
R5262	T8048	T8047	compound	filter,strips
R5263	T8049	T8044	prep	into,inserting
R5264	T8050	T8051	det	the,base
R5265	T8051	T8049	pobj	base,into
R5266	T8052	T8044	cc	and,inserting
R5267	T8053	T8054	npadvmod	DiA,soaked
R5268	T8054	T8055	amod	soaked,strips
R5269	T8055	T8044	conj	strips,inserting
R527	T1066	T1059	prep	to,leads
R5270	T8056	T8055	compound	filter,strips
R5271	T8057	T8055	prep	into,strips
R5272	T8058	T8059	det	the,turn
R5273	T8059	T8057	pobj	turn,into
R5274	T8060	T8059	amod	apical,turn
R5275	T8061	T8059	prep	of,turn
R5276	T8062	T8063	nummod	2,P0
R5277	T8063	T8061	pobj	P0,of
R5278	T8064	T8063	cc	and,P0
R5279	T8065	T8066	nummod	4,P8
R528	T1067	T1068	advmod	topologically,restricted
R5280	T8066	T8067	nmod	P8,mutants
R5281	T8067	T8063	conj	mutants,P0
R5282	T8068	T8067	nmod	Brn3c,mutants
R5283	T8069	T8067	amod	null,mutants
R5284	T8070	T8063	cc	and,P0
R5285	T8071	T8072	det	a,number
R5286	T8072	T8063	conj	number,P0
R5287	T8073	T8072	amod	similar,number
R5288	T8074	T8072	prep	of,number
R5289	T8075	T8076	amod	wildtype,littermates
R529	T1068	T1069	amod	restricted,loss
R5290	T8076	T8074	pobj	littermates,of
R5291	T8077	T8041	punct	.,evaluated
R5292	T8079	T8080	prep	After,embedded
R5293	T8081	T8082	amod	appropriate,time
R5294	T8082	T8079	pobj	time,After
R5295	T8083	T8082	compound	diffusion,time
R5296	T8084	T8085	punct	[,43
R5297	T8085	T8079	parataxis	43,After
R5298	T8086	T8085	punct	],43
R5299	T8087	T8080	punct	", ",embedded
R53	T247	T248	amod	sensory,neurons
R530	T1069	T1066	pobj	loss,to
R5300	T8088	T8089	det	the,brains
R5301	T8089	T8080	nsubjpass	brains,embedded
R5302	T8090	T8089	prep	with,brains
R5303	T8091	T8092	det	the,nerve
R5304	T8092	T8090	pobj	nerve,with
R5305	T8093	T8092	amod	attached,nerve
R5306	T8094	T8092	amod	cochlear,nerve
R5307	T8095	T8080	auxpass	were,embedded
R5308	T8096	T8080	prep	in,embedded
R5309	T8097	T8096	pobj	gelatin,in
R531	T1070	T1069	prep	of,loss
R5310	T8098	T8080	punct	", ",embedded
R5311	T8099	T8080	conj	hardened,embedded
R5312	T8100	T8099	prep	in,hardened
R5313	T8101	T8102	nummod	4,%
R5314	T8102	T8103	compound	%,PFA
R5315	T8103	T8100	pobj	PFA,in
R5316	T8104	T8099	prep	over,hardened
R5317	T8105	T8104	pobj	night,over
R5318	T8106	T8099	punct	", ",hardened
R5319	T8107	T8099	conj	sectioned,hardened
R532	T1071	T1072	amod	sensory,neurons
R5320	T8108	T8107	advmod	coronally,sectioned
R5321	T8109	T8107	prep	on,sectioned
R5322	T8110	T8111	det	a,vibratome
R5323	T8111	T8109	pobj	vibratome,on
R5324	T8112	T8113	punct	(,thickness
R5325	T8113	T8107	parataxis	thickness,sectioned
R5326	T8114	T8115	nummod	100,μm
R5327	T8115	T8113	compound	μm,thickness
R5328	T8116	T8113	punct	),thickness
R5329	T8117	T8107	cc	and,sectioned
R533	T1072	T1070	pobj	neurons,of
R5330	T8118	T8107	conj	viewed,sectioned
R5331	T8119	T8118	prep	with,viewed
R5332	T8120	T8121	det	a,system
R5333	T8121	T8119	pobj	system,with
R5334	T8122	T8123	nmod	Biorad,Radiance
R5335	T8123	T8121	nmod	Radiance,system
R5336	T8124	T8123	nummod	2000,Radiance
R5337	T8125	T8121	amod	confocal,system
R5338	T8126	T8121	acl	attached,system
R5339	T8127	T8126	prep	to,attached
R534	T1073	T1069	prep	in,loss
R5340	T8128	T8129	det	a,microscope
R5341	T8129	T8127	pobj	microscope,to
R5342	T8130	T8131	nmod	Nikon,Eclipse
R5343	T8131	T8129	nmod	Eclipse,microscope
R5344	T8132	T8131	nummod	800,Eclipse
R5345	T8133	T8080	punct	.,embedded
R5346	T8135	T8136	compound	Image,stacks
R5347	T8136	T8137	nsubjpass	stacks,collapsed
R5348	T8138	T8137	auxpass	were,collapsed
R5349	T8139	T8140	aux	to,view
R535	T1074	T1075	det	the,ear
R5350	T8140	T8137	advcl	view,collapsed
R5351	T8141	T8142	det	the,projection
R5352	T8142	T8140	dobj	projection,view
R5353	T8143	T8142	amod	entire,projection
R5354	T8144	T8140	prep	in,view
R5355	T8145	T8146	nummod	one,section
R5356	T8146	T8144	pobj	section,in
R5357	T8147	T8140	prep	in,view
R5358	T8148	T8149	nummod	one,plane
R5359	T8149	T8147	pobj	plane,in
R536	T1075	T1073	pobj	ear,in
R5360	T8150	T8149	amod	focal,plane
R5361	T8151	T8137	punct	.,collapsed
R5362	T8171	T8172	advmod	In,situ
R5363	T8172	T8173	amod	situ,hybridization
R5364	T8175	T8176	nummod	Four,ears
R5365	T8176	T8177	nsubjpass	ears,embedded
R5366	T8178	T8176	appos	each,ears
R5367	T8179	T8176	prep	of,ears
R5368	T8180	T8181	npadvmod	Brn3c,null
R5369	T8181	T8182	amod	null,mutants
R537	T1076	T1075	amod	embryonic,ear
R5370	T8182	T8179	pobj	mutants,of
R5371	T8183	T8184	punct	(,P0
R5372	T8184	T8182	parataxis	P0,mutants
R5373	T8185	T8184	cc	and,P0
R5374	T8186	T8184	conj	P8,P0
R5375	T8187	T8184	punct	),P0
R5376	T8188	T8182	cc	and,mutants
R5377	T8189	T8190	compound	control,littermates
R5378	T8190	T8182	conj	littermates,mutants
R5379	T8191	T8177	auxpass	were,embedded
R538	T1077	T1078	punct	[,5
R5380	T8192	T8177	prep	in,embedded
R5381	T8193	T8192	pobj	paraffin,in
R5382	T8194	T8177	punct	", ",embedded
R5383	T8195	T8177	conj	sectioned,embedded
R5384	T8196	T8195	cc	and,sectioned
R5385	T8197	T8195	conj	probed,sectioned
R5386	T8198	T8197	prep	for,probed
R5387	T8199	T8200	det	the,presence
R5388	T8200	T8198	pobj	presence,for
R5389	T8201	T8200	prep	of,presence
R539	T1078	T1048	parataxis	5,shown
R5390	T8202	T8203	nmod	BDNF,mRNA
R5391	T8203	T8201	pobj	mRNA,of
R5392	T8204	T8202	cc	and,BDNF
R5393	T8205	T8202	conj	NT,BDNF
R5394	T8206	T8205	punct	-,NT
R5395	T8207	T8205	nummod	3,NT
R5396	T8208	T8197	advcl	using,probed
R5397	T8209	T8210	det	the,technique
R5398	T8210	T8208	dobj	technique,using
R5399	T8211	T8212	advmod	in,situ
R54	T248	T246	dobj	neurons,sustain
R540	T1079	T1078	nummod	4,5
R5400	T8212	T8210	amod	situ,technique
R5401	T8213	T8214	advmod	previously,described
R5402	T8214	T8210	acl	described,technique
R5403	T8215	T8216	punct	[,7
R5404	T8216	T8197	parataxis	7,probed
R5405	T8217	T8216	punct	],7
R5406	T8218	T8177	punct	.,embedded
R5407	T8220	T8221	nsubjpass	Sections,counterstained
R5408	T8222	T8221	auxpass	were,counterstained
R5409	T8223	T8221	advmod	lightly,counterstained
R541	T1080	T1078	punct	",",5
R5410	T8224	T8221	cc	and,counterstained
R5411	T8225	T8221	conj	viewed,counterstained
R5412	T8226	T8225	prep	with,viewed
R5413	T8227	T8228	amod	bright,field
R5414	T8228	T8231	compound	field,microscopy
R5415	T8229	T8227	cc	and,bright
R5416	T8230	T8227	conj	dark,bright
R5417	T8231	T8226	pobj	microscopy,with
R5418	T8232	T8221	punct	.,counterstained
R5419	T8234	T8235	nsubjpass	Images,acquired
R542	T1081	T1078	punct	],5
R5420	T8236	T8235	auxpass	were,acquired
R5421	T8237	T8235	prep	with,acquired
R5422	T8238	T8239	det	a,camera
R5423	T8239	T8237	pobj	camera,with
R5424	T8240	T8239	compound	CCD,camera
R5425	T8241	T8235	cc	and,acquired
R5426	T8242	T8235	conj	displayed,acquired
R5427	T8243	T8242	prep	as,displayed
R5428	T8244	T8245	amod	false,images
R5429	T8245	T8243	pobj	images,as
R543	T1082	T1048	punct	.,shown
R5430	T8246	T8245	compound	color,images
R5431	T8247	T8248	mark	as,described
R5432	T8248	T8242	advcl	described,displayed
R5433	T8249	T8248	advmod	previously,described
R5434	T8250	T8251	punct	[,18
R5435	T8251	T8242	parataxis	18,displayed
R5436	T8252	T8251	punct	],18
R5437	T8253	T8235	punct	.,acquired
R5438	T8328	T8327	prep	of,Immunocytochemistry
R5439	T8329	T8330	compound	hair,cells
R544	T1084	T1085	amod	Such,loss
R5440	T8330	T8328	pobj	cells,of
R5441	T8331	T8327	cc	and,Immunocytochemistry
R5442	T8332	T8327	conj	quantification,Immunocytochemistry
R5443	T8333	T8332	prep	of,quantification
R5444	T8334	T8335	compound	hair,cells
R5445	T8335	T8333	pobj	cells,of
R5446	T8336	T8335	cc	and,cells
R5447	T8337	T8335	conj	neurons,cells
R5448	T8339	T8340	nsubjpass	Immunostaining,performed
R5449	T8341	T8339	prep	of,Immunostaining
R545	T1085	T1087	nsubj	loss,indicate
R5450	T8342	T8343	nmod	P7,mounts
R5451	T8343	T8341	pobj	mounts,of
R5452	T8344	T8343	amod	cochlear,mounts
R5453	T8345	T8343	amod	whole,mounts
R5454	T8346	T8339	acl	using,Immunostaining
R5455	T8347	T8348	det	the,antibody
R5456	T8348	T8346	dobj	antibody,using
R5457	T8349	T8350	compound	hair,cell
R5458	T8350	T8351	npadvmod	cell,specific
R5459	T8351	T8348	amod	specific,antibody
R546	T1086	T1085	amod	selective,loss
R5460	T8352	T8348	punct	-,antibody
R5461	T8353	T8348	nmod	myosin,antibody
R5462	T8354	T8353	nummod	VII,myosin
R5463	T8355	T8353	punct	(,myosin
R5464	T8356	T8353	appos	MyoVIIa,myosin
R5465	T8357	T8348	punct	),antibody
R5466	T8358	T8340	auxpass	was,performed
R5467	T8359	T8360	mark	as,described
R5468	T8360	T8340	advcl	described,performed
R5469	T8361	T8360	advmod	previously,described
R547	T1088	T1085	prep	in,loss
R5470	T8362	T8363	punct	[,2
R5471	T8363	T8340	parataxis	2,performed
R5472	T8364	T8363	punct	],2
R5473	T8365	T8340	punct	.,performed
R5474	T8367	T8368	nsubjpass	Images,acquired
R5475	T8369	T8367	prep	of,Images
R5476	T8370	T8371	amod	labeled,organs
R5477	T8371	T8369	pobj	organs,of
R5478	T8372	T8371	prep	of,organs
R5479	T8373	T8372	pobj	Corti,of
R548	T1089	T1090	nmod	Brn3c,mutants
R5480	T8374	T8368	auxpass	were,acquired
R5481	T8375	T8368	advmod	then,acquired
R5482	T8376	T8368	advcl	using,acquired
R5483	T8377	T8378	det	a,camera
R5484	T8378	T8376	dobj	camera,using
R5485	T8379	T8378	nmod	SPOT,camera
R5486	T8380	T8378	amod	digital,camera
R5487	T8381	T8382	punct	(,Inc.
R5488	T8382	T8378	parataxis	Inc.,camera
R5489	T8383	T8382	compound	Diagnostic,Inc.
R549	T1090	T1088	pobj	mutants,in
R5490	T8384	T8382	compound	Instruments,Inc.
R5491	T8385	T8382	punct	),Inc.
R5492	T8386	T8368	cc	and,acquired
R5493	T8387	T8388	det	the,number
R5494	T8388	T8389	nsubjpass	number,scored
R5495	T8389	T8368	conj	scored,acquired
R5496	T8390	T8388	prep	of,number
R5497	T8391	T8392	compound	hair,cells
R5498	T8392	T8390	pobj	cells,of
R5499	T8393	T8389	auxpass	was,scored
R55	T249	T246	prep	through,sustain
R550	T1091	T1090	amod	null,mutants
R5500	T8394	T8389	prep	from,scored
R5501	T8395	T8396	amod	acquired,images
R5502	T8396	T8394	pobj	images,from
R5503	T8397	T8389	punct	.,scored
R5504	T8399	T8400	aux	To,determine
R5505	T8400	T8401	advcl	determine,stained
R5506	T8402	T8403	det	the,number
R5507	T8403	T8400	dobj	number,determine
R5508	T8404	T8403	prep	of,number
R5509	T8405	T8406	compound	hair,cells
R551	T1092	T1087	aux	would,indicate
R5510	T8406	T8404	pobj	cells,of
R5511	T8407	T8406	cc	or,cells
R5512	T8408	T8406	conj	neurons,cells
R5513	T8409	T8400	prep	in,determine
R5514	T8410	T8411	amod	vestibular,endorgans
R5515	T8411	T8409	pobj	endorgans,in
R5516	T8412	T8411	cc	or,endorgans
R5517	T8413	T8414	amod	sensory,ganglia
R5518	T8414	T8411	conj	ganglia,endorgans
R5519	T8415	T8401	punct	", ",stained
R552	T1093	T1087	advmod	therefore,indicate
R5520	T8416	T8417	amod	serial,sections
R5521	T8417	T8401	nsubjpass	sections,stained
R5522	T8418	T8401	auxpass	were,stained
R5523	T8419	T8401	prep	with,stained
R5524	T8420	T8421	compound	Cresyl,Violet
R5525	T8421	T8419	pobj	Violet,with
R5526	T8422	T8401	cc	and,stained
R5527	T8423	T8424	nsubjpass	images,acquired
R5528	T8424	T8401	conj	acquired,stained
R5529	T8425	T8424	auxpass	were,acquired
R553	T1094	T1087	dobj	reduction,indicate
R5530	T8426	T8424	advmod	similarly,acquired
R5531	T8427	T8424	cc	and,acquired
R5532	T8428	T8424	conj	scored,acquired
R5533	T8429	T8401	punct	.,stained
R5534	T8431	T8432	det	Every,section
R5535	T8432	T8434	nsubjpass	section,scored
R5536	T8433	T8432	amod	other,section
R5537	T8435	T8434	auxpass	was,scored
R5538	T8436	T8434	prep	for,scored
R5539	T8437	T8438	det	each,epithelium
R554	T1095	T1094	prep	of,reduction
R5540	T8438	T8436	pobj	epithelium,for
R5541	T8439	T8438	amod	sensory,epithelium
R5542	T8440	T8434	cc	and,scored
R5543	T8441	T8442	det	every,section
R5544	T8442	T8444	nsubjpass	section,scored
R5545	T8443	T8442	amod	forth,section
R5546	T8444	T8434	conj	scored,scored
R5547	T8445	T8444	auxpass	was,scored
R5548	T8446	T8444	prep	for,scored
R5549	T8447	T8448	det	each,ganglion
R555	T1096	T1097	det	a,neurotrophin
R5550	T8448	T8446	pobj	ganglion,for
R5551	T8449	T8444	punct	.,scored
R5552	T8451	T8452	advmod	Only,neurons
R5553	T8452	T8453	nsubjpass	neurons,counted
R5554	T8454	T8452	cc	or,neurons
R5555	T8455	T8452	conj	cells,neurons
R5556	T8456	T8452	prep	with,neurons
R5557	T8457	T8458	det	a,nucleus
R5558	T8458	T8456	pobj	nucleus,with
R5559	T8459	T8458	amod	clear,nucleus
R556	T1097	T1095	pobj	neurotrophin,of
R5560	T8460	T8458	cc	and,nucleus
R5561	T8461	T8458	conj	nucleoli,nucleus
R5562	T8462	T8453	auxpass	were,counted
R5563	T8463	T8453	cc	and,counted
R5564	T8464	T8465	quantmod	4,6
R5565	T8465	T8467	nummod	6,samples
R5566	T8466	T8465	punct	–,6
R5567	T8467	T8468	nsubjpass	samples,counted
R5568	T8468	T8453	conj	counted,counted
R5569	T8469	T8468	auxpass	were,counted
R557	T1098	T1097	amod	specific,neurotrophin
R5570	T8470	T8468	prep	for,counted
R5571	T8471	T8472	det	each,epithelium
R5572	T8472	T8470	pobj	epithelium,for
R5573	T8473	T8472	cc	and,epithelium
R5574	T8474	T8472	conj	ganglion,epithelium
R5575	T8475	T8468	punct	.,counted
R5576	T8477	T8478	det	All,data
R5577	T8478	T8479	nsubjpass	data,tested
R5578	T8480	T8479	auxpass	were,tested
R5579	T8481	T8479	prep	for,tested
R558	T1099	T1094	prep	in,reduction
R5580	T8482	T8481	pobj	significance,for
R5581	T8483	T8479	advcl	using,tested
R5582	T8484	T8485	amod	two,Student
R5583	T8485	T8488	poss	Student,test
R5584	T8486	T8485	punct	-,Student
R5585	T8487	T8485	amod	sample,Student
R5586	T8488	T8483	dobj	test,using
R5587	T8489	T8485	case	's,Student
R5588	T8490	T8488	compound	t,test
R5589	T8491	T8488	punct	-,test
R559	T1100	T1101	amod	immature,cells
R5590	T8492	T8488	prep	with,test
R5591	T8493	T8494	amod	unequal,variances
R5592	T8494	T8492	pobj	variances,with
R5593	T8495	T8479	punct	.,tested
R56	T250	T251	amod	embryonic,development
R560	T1101	T1099	pobj	cells,in
R5602	T8591	T8592	compound	Size,variations
R5603	T8593	T8592	prep	of,variations
R5604	T8594	T8595	amod	vestibular,ganglia
R5605	T8595	T8593	pobj	ganglia,of
R5606	T8596	T8592	prep	in,variations
R5607	T8597	T8598	nmod	control,littermates
R5608	T8598	T8596	pobj	littermates,in
R5609	T8599	T8597	cc	and,control
R561	T1102	T1101	compound	hair,cells
R5610	T8600	T8597	conj	mutant,control
R5611	T8601	T8592	acl	labeled,variations
R5612	T8602	T8601	prep	with,labeled
R5613	T8603	T8602	pobj	DiI,with
R5614	T8604	T8592	punct	.,variations
R5615	T8606	T8607	prep	In,shows
R5616	T8608	T8609	amod	newborn,animals
R5617	T8609	T8606	pobj	animals,In
R5618	T8610	T8607	punct	", ",shows
R5619	T8611	T8612	det	the,ganglion
R562	T1103	T1087	punct	.,indicate
R5620	T8612	T8607	nsubj	ganglion,shows
R5621	T8613	T8612	amod	vestibular,ganglion
R5622	T8614	T8615	det	a,reduction
R5623	T8615	T8607	dobj	reduction,shows
R5624	T8616	T8615	amod	dramatic,reduction
R5625	T8617	T8615	prep	in,reduction
R5626	T8618	T8619	npadvmod	Brn3c,null
R5627	T8619	T8620	amod	null,mutants
R5628	T8620	T8617	pobj	mutants,in
R5629	T8621	T8622	punct	(,b
R563	T1105	T1106	advmod	Moreover,shows
R5630	T8622	T8620	parataxis	b,mutants
R5631	T8623	T8622	punct	),b
R5632	T8624	T8615	prep	compared,reduction
R5633	T8625	T8624	prep	to,compared
R5634	T8626	T8627	compound	control,littermates
R5635	T8627	T8625	pobj	littermates,to
R5636	T8628	T8629	punct	(,a
R5637	T8629	T8627	parataxis	a,littermates
R5638	T8630	T8629	punct	),a
R5639	T8631	T8607	punct	.,shows
R564	T1107	T1106	punct	", ",shows
R5640	T8633	T8634	dep	Abbreviations,AC
R5641	T8635	T8633	prep	for,Abbreviations
R5642	T8636	T8635	pobj	this,for
R5643	T8637	T8636	cc	and,this
R5644	T8638	T8639	nmod	other,figures
R5645	T8639	T8636	conj	figures,this
R5646	T8640	T8634	punct	: ,AC
R5647	T8641	T8634	punct	", ",AC
R5648	T8642	T8643	amod	anterior,crista
R5649	T8643	T8634	appos	crista,AC
R565	T1108	T1109	amod	recent,work
R5650	T8644	T8634	punct	;,AC
R5651	T8645	T8634	appos	ggl,AC
R5652	T8646	T8645	punct	", ",ggl
R5653	T8647	T8645	appos	ganglion,ggl
R5654	T8648	T8634	punct	;,AC
R5655	T8649	T8634	appos	c,AC
R5656	T8650	T8649	punct	", ",c
R5657	T8651	T8652	amod	spiral,capillary
R5658	T8652	T8649	appos	capillary,c
R5659	T8653	T8634	punct	;,AC
R566	T1109	T1106	nsubj	work,shows
R5660	T8654	T8655	compound	Genic.,ggl.
R5661	T8655	T8634	appos	ggl.,AC
R5662	T8656	T8655	punct	", ",ggl.
R5663	T8657	T8658	amod	geniculate,ganglion
R5664	T8658	T8655	appos	ganglion,ggl.
R5665	T8659	T8660	punct	;,GER
R5666	T8660	T8634	appos	GER,AC
R5667	T8661	T8660	punct	", ",GER
R5668	T8662	T8663	amod	greater,ridge
R5669	T8663	T8660	appos	ridge,GER
R567	T1110	T1111	mark	that,expressed
R5670	T8664	T8663	amod	epithelial,ridge
R5671	T8665	T8634	punct	;,AC
R5672	T8666	T8634	appos	HC,AC
R5673	T8667	T8666	punct	", ",HC
R5674	T8668	T8669	amod	horizontal,crista
R5675	T8669	T8666	appos	crista,HC
R5676	T8670	T8634	punct	;,AC
R5677	T8671	T8634	appos	HaC,AC
R5678	T8672	T8671	punct	", ",HaC
R5679	T8673	T8674	amod	vestibular,cell
R568	T1111	T1106	ccomp	expressed,shows
R5680	T8674	T8671	appos	cell,HaC
R5681	T8675	T8674	compound	hair,cell
R5682	T8676	T8634	punct	;,AC
R5683	T8677	T8634	appos	IHC,AC
R5684	T8678	T8677	punct	", ",IHC
R5685	T8679	T8680	amod	inner,cell
R5686	T8680	T8677	appos	cell,IHC
R5687	T8681	T8680	compound	hair,cell
R5688	T8682	T8634	punct	;,AC
R5689	T8683	T8634	appos	iHC,AC
R569	T1112	T1111	prep	in,expressed
R5690	T8684	T8683	punct	", ",iHC
R5691	T8685	T8686	amod	immature,cell
R5692	T8686	T8683	appos	cell,iHC
R5693	T8687	T8686	compound	hair,cell
R5694	T8688	T8634	punct	;,AC
R5695	T8689	T8634	appos	IGSB,AC
R5696	T8690	T8689	punct	", ",IGSB
R5697	T8691	T8692	amod	intraganglionic,bundle
R5698	T8692	T8689	appos	bundle,IGSB
R5699	T8693	T8692	amod	spiral,bundle
R57	T251	T249	pobj	development,through
R570	T1113	T1112	pobj	embryos,in
R5700	T8694	T8634	punct	;,AC
R5701	T8695	T8634	appos	OHC,AC
R5702	T8696	T8695	punct	", ",OHC
R5703	T8697	T8698	amod	outer,cell
R5704	T8698	T8695	appos	cell,OHC
R5705	T8699	T8698	compound	hair,cell
R5706	T8700	T8634	punct	;,AC
R5707	T8701	T8634	appos	PC,AC
R5708	T8702	T8701	punct	", ",PC
R5709	T8703	T8704	amod	posterior,crista
R571	T1114	T1111	nsubjpass	NT,expressed
R5710	T8704	T8701	appos	crista,PC
R5711	T8705	T8634	punct	;,AC
R5712	T8706	T8634	appos	S,AC
R5713	T8707	T8706	punct	", ",S
R5714	T8708	T8706	appos	saccule,S
R5715	T8709	T8634	punct	;,AC
R5716	T8710	T8634	appos	SG,AC
R5717	T8711	T8710	punct	", ",SG
R5718	T8712	T8713	amod	spiral,ganglion
R5719	T8713	T8710	appos	ganglion,SG
R572	T1115	T1114	punct	-,NT
R5720	T8714	T8634	punct	;,AC
R5721	T8715	T8634	appos	TM,AC
R5722	T8716	T8715	punct	", ",TM
R5723	T8717	T8718	amod	tectorial,membrane
R5724	T8718	T8715	appos	membrane,TM
R5725	T8719	T8634	punct	;,AC
R5726	T8720	T8634	appos	U,AC
R5727	T8721	T8720	punct	", ",U
R5728	T8722	T8720	appos	utricle,U
R5729	T8723	T8634	punct	;,AC
R573	T1116	T1114	nummod	3,NT
R5730	T8724	T8634	appos	VCN,AC
R5731	T8725	T8724	punct	", ",VCN
R5732	T8726	T8727	amod	ventral,nucleus
R5733	T8727	T8724	appos	nucleus,VCN
R5734	T8728	T8727	amod	cochlear,nucleus
R5735	T8729	T8634	punct	;,AC
R5736	T8730	T8634	appos	VG,AC
R5737	T8731	T8730	punct	", ",VG
R5738	T8732	T8733	amod	vestibular,ganglion
R5739	T8733	T8730	appos	ganglion,VG
R574	T1117	T1111	auxpass	is,expressed
R5740	T8734	T8634	punct	.,AC
R5741	T8736	T8737	nsubj	Bar,indicates
R5742	T8738	T8739	nummod	1000,μm
R5743	T8739	T8737	dobj	μm,indicates
R5744	T8740	T8737	punct	.,indicates
R5745	T8782	T8783	nsubjpass	Innervation,shown
R5746	T8784	T8782	prep	of,Innervation
R5747	T8785	T8786	nmod	Brn3c,ears
R5748	T8786	T8784	pobj	ears,of
R5749	T8787	T8788	amod	null,control
R575	T1118	T1111	advmod	primarily,expressed
R5750	T8788	T8786	compound	control,ears
R5751	T8789	T8788	cc	and,control
R5752	T8790	T8783	auxpass	are,shown
R5753	T8791	T8783	prep	for,shown
R5754	T8792	T8793	amod	newborn,mice
R5755	T8793	T8791	pobj	mice,for
R5756	T8794	T8783	punct	.,shown
R5757	T8796	T8797	expl	There,is
R5758	T8798	T8799	det	no,loss
R5759	T8799	T8797	attr	loss,is
R576	T1119	T1111	prep	in,expressed
R5760	T8800	T8799	amod	specific,loss
R5761	T8801	T8799	prep	of,loss
R5762	T8802	T8801	pobj	fibers,of
R5763	T8803	T8799	prep	to,loss
R5764	T8804	T8805	det	any,endorgan
R5765	T8805	T8803	pobj	endorgan,to
R5766	T8806	T8805	amod	vestibular,endorgan
R5767	T8807	T8797	punct	", ",is
R5768	T8808	T8809	mark	as,visualized
R5769	T8809	T8797	advcl	visualized,is
R577	T1120	T1121	amod	supporting,cells
R5770	T8810	T8809	agent	by,visualized
R5771	T8811	T8812	compound	DiI,labeling
R5772	T8812	T8810	pobj	labeling,by
R5773	T8813	T8814	punct	(,a
R5774	T8814	T8812	parataxis	a,labeling
R5775	T8815	T8814	punct	),a
R5776	T8816	T8812	cc	or,labeling
R5777	T8817	T8818	amod	acetylated,tubulin
R5778	T8818	T8819	compound	tubulin,immunoreactivity
R5779	T8819	T8812	conj	immunoreactivity,labeling
R578	T1121	T1119	pobj	cells,in
R5780	T8820	T8821	punct	(,b
R5781	T8821	T8797	parataxis	b,is
R5782	T8822	T8821	punct	),b
R5783	T8823	T8797	punct	.,is
R5784	T8825	T8826	det	No,differences
R5785	T8826	T8828	nsubjpass	differences,found
R5786	T8827	T8826	amod	major,differences
R5787	T8829	T8826	prep	in,differences
R5788	T8830	T8829	pobj	pattern,in
R5789	T8831	T8830	prep	of,pattern
R579	T1122	T1111	punct	", ",expressed
R5790	T8832	T8831	pobj	projection,of
R5791	T8833	T8832	prep	through,projection
R5792	T8834	T8835	compound	radial,fibers
R5793	T8835	T8833	pobj	fibers,through
R5794	T8836	T8828	auxpass	are,found
R5795	T8837	T8828	prep	in,found
R5796	T8838	T8839	det	the,cochlea
R5797	T8839	T8837	pobj	cochlea,in
R5798	T8840	T8839	prep	of,cochlea
R5799	T8841	T8842	nmod	Brn3c,mutants
R58	T252	T236	punct	.,lead
R580	T1123	T1111	advcl	moving,expressed
R5800	T8842	T8840	pobj	mutants,of
R5801	T8843	T8842	amod	null,mutants
R5802	T8844	T8845	punct	(,f
R5803	T8845	T8842	parataxis	f,mutants
R5804	T8846	T8845	nmod	d,f
R5805	T8847	T8845	punct	",",f
R5806	T8848	T8845	punct	),f
R5807	T8849	T8828	prep	as,found
R5808	T8850	T8849	prep	compared,as
R5809	T8851	T8850	prep	to,compared
R581	T1124	T1125	advmod	only,around
R5810	T8852	T8853	compound	control,littermates
R5811	T8853	T8851	pobj	littermates,to
R5812	T8854	T8855	punct	(,c
R5813	T8855	T8853	parataxis	c,littermates
R5814	T8856	T8855	punct	),c
R5815	T8857	T8828	punct	.,found
R5816	T8860	T8859	punct	", ",Note
R5817	T8861	T8859	advmod	however,Note
R5818	T8862	T8859	punct	", ",Note
R5819	T8863	T8864	det	the,lack
R582	T1125	T1123	prep	around,moving
R5820	T8864	T8859	dobj	lack,Note
R5821	T8865	T8864	prep	of,lack
R5822	T8866	T8867	amod	orderly,outgrowth
R5823	T8867	T8865	pobj	outgrowth,of
R5824	T8868	T8867	compound	fiber,outgrowth
R5825	T8869	T8867	prep	to,outgrowth
R5826	T8870	T8871	det	the,cells
R5827	T8871	T8869	pobj	cells,to
R5828	T8872	T8871	amod	outer,cells
R5829	T8873	T8871	compound	hair,cells
R583	T1126	T1125	pobj	birth,around
R5830	T8874	T8875	punct	(,d
R5831	T8875	T8859	parataxis	d,Note
R5832	T8876	T8875	nmod	c,d
R5833	T8877	T8875	punct	", ",d
R5834	T8878	T8875	punct	),d
R5835	T8879	T8859	punct	.,Note
R5836	T8881	T8882	amod	Efferent,fibers
R5837	T8882	T8883	nsubj	fibers,show
R5838	T8884	T8882	prep	to,fibers
R5839	T8885	T8886	det	the,ear
R584	T1127	T1123	prep	into,moving
R5840	T8886	T8884	pobj	ear,to
R5841	T8887	T8888	det	a,bundle
R5842	T8888	T8883	dobj	bundle,show
R5843	T8889	T8890	advmod	well,developed
R5844	T8890	T8888	amod	developed,bundle
R5845	T8891	T8888	amod	intraganglionic,bundle
R5846	T8892	T8888	amod	spiral,bundle
R5847	T8893	T8888	punct	(,bundle
R5848	T8894	T8888	appos	IGSB,bundle
R5849	T8895	T8888	punct	),bundle
R585	T1128	T1129	compound	hair,cells
R5850	T8896	T8888	prep	with,bundle
R5851	T8897	T8898	det	no,differences
R5852	T8898	T8896	pobj	differences,with
R5853	T8899	T8898	amod	detectable,differences
R5854	T8900	T8898	prep	compared,differences
R5855	T8901	T8900	prep	to,compared
R5856	T8902	T8901	pobj	controls,to
R5857	T8903	T8904	punct	(,e
R5858	T8904	T8883	parataxis	e,show
R5859	T8905	T8904	punct	),e
R586	T1129	T1127	pobj	cells,into
R5860	T8906	T8883	punct	.,show
R5861	T8908	T8909	nsubj	Bar,indicates
R5862	T8910	T8911	nummod	100,μm
R5863	T8911	T8909	dobj	μm,indicates
R5864	T8912	T8909	punct	.,indicates
R5865	T8959	T8960	nsubjpass	Reduction,shown
R5866	T8961	T8959	prep	of,Reduction
R5867	T8962	T8961	pobj	innervation,of
R5868	T8963	T8962	prep	of,innervation
R5869	T8964	T8965	det	the,ear
R587	T1130	T1131	punct	[,7
R5870	T8965	T8963	pobj	ear,of
R5871	T8966	T8960	auxpass	is,shown
R5872	T8967	T8960	prep	in,shown
R5873	T8968	T8969	amod	8,day
R5874	T8969	T8971	amod	day,old
R5875	T8970	T8969	punct	-,day
R5876	T8971	T8972	amod	old,mice
R5877	T8972	T8967	pobj	mice,in
R5878	T8973	T8960	punct	.,shown
R5879	T8975	T8976	mark	While,retain
R588	T1131	T1106	parataxis	7,shows
R5880	T8976	T8981	advcl	retain,is
R5881	T8977	T8978	det	all,epithelia
R5882	T8978	T8976	nsubj	epithelia,retain
R5883	T8979	T8978	amod	vestibular,epithelia
R5884	T8980	T8978	amod	sensory,epithelia
R5885	T8982	T8983	det	some,innervation
R5886	T8983	T8976	dobj	innervation,retain
R5887	T8984	T8983	amod	afferent,innervation
R5888	T8985	T8986	punct	(,a
R5889	T8986	T8984	parataxis	a,afferent
R589	T1132	T1131	nummod	6,7
R5890	T8987	T8986	punct	),a
R5891	T8988	T8984	cc	and,afferent
R5892	T8989	T8984	conj	efferent,afferent
R5893	T8990	T8991	punct	(,b
R5894	T8991	T8989	parataxis	b,efferent
R5895	T8992	T8991	punct	),b
R5896	T8993	T8981	punct	", ",is
R5897	T8994	T8981	expl	there,is
R5898	T8995	T8996	det	a,reduction
R5899	T8996	T8981	attr	reduction,is
R59	T254	T255	nsubj	We,investigated
R590	T1133	T1131	punct	",",7
R5900	T8997	T8998	advmod	more,pronounced
R5901	T8998	T8996	amod	pronounced,reduction
R5902	T8999	T8996	punct	", ",reduction
R5903	T9000	T9001	prep	in,of
R5904	T9001	T8996	prep	of,reduction
R5905	T9002	T9000	amod	particular,in
R5906	T9003	T9004	amod	efferent,fibers
R5907	T9004	T9001	pobj	fibers,of
R5908	T9005	T8996	punct	", ",reduction
R5909	T9006	T8996	prep	to,reduction
R591	T1134	T1131	punct	],7
R5910	T9007	T9008	det	the,utricle
R5911	T9008	T9006	pobj	utricle,to
R5912	T9009	T9010	punct	(,b
R5913	T9010	T8996	parataxis	b,reduction
R5914	T9011	T9010	nmod	a,b
R5915	T9012	T9010	punct	",",b
R5916	T9013	T9010	punct	),b
R5917	T9014	T8996	prep	as,reduction
R5918	T9015	T9014	prep	compared,as
R5919	T9016	T9015	prep	to,compared
R592	T1135	T1106	punct	.,shows
R5920	T9017	T9018	det	the,canals
R5921	T9018	T9016	pobj	canals,to
R5922	T9019	T8981	punct	.,is
R5923	T9021	T9022	prep	In,is
R5924	T9023	T9024	det	the,cochlea
R5925	T9024	T9021	pobj	cochlea,In
R5926	T9025	T9022	expl	there,is
R5927	T9026	T9027	det	an,spacing
R5928	T9027	T9022	attr	spacing,is
R5929	T9028	T9027	amod	increased,spacing
R593	T1137	T1138	prep	In,suggests
R5930	T9029	T9022	prep	between,is
R5931	T9030	T9031	amod	radial,bundles
R5932	T9031	T9029	pobj	bundles,between
R5933	T9032	T9031	compound	fiber,bundles
R5934	T9033	T9022	prep	in,is
R5935	T9034	T9035	det	the,turn
R5936	T9035	T9033	pobj	turn,in
R5937	T9036	T9035	amod	basal,turn
R5938	T9037	T9038	punct	(,e
R5939	T9038	T9022	parataxis	e,is
R594	T1139	T1137	pobj	fact,In
R5940	T9039	T9038	nmod	c,e
R5941	T9040	T9038	punct	",",e
R5942	T9041	T9038	punct	),e
R5943	T9042	T9022	punct	.,is
R5944	T9044	T9045	det	No,afferents
R5945	T9045	T9046	nsubjpass	afferents,traced
R5946	T9047	T9046	aux	can,traced
R5947	T9048	T9046	auxpass	be,traced
R5948	T9049	T9046	prep	to,traced
R5949	T9050	T9051	det	the,bundles
R595	T1140	T1138	punct	", ",suggests
R5950	T9051	T9049	pobj	bundles,to
R5951	T9052	T9051	nummod	three,bundles
R5952	T9053	T9051	amod	outer,bundles
R5953	T9054	T9051	amod	spiral,bundles
R5954	T9055	T9051	prep	along,bundles
R5955	T9056	T9057	amod	outer,cells
R5956	T9057	T9055	pobj	cells,along
R5957	T9058	T9057	compound	hair,cells
R5958	T9059	T9051	prep	of,bundles
R5959	T9060	T9061	amod	mutant,littermates
R596	T1141	T1142	det	the,loss
R5960	T9061	T9059	pobj	littermates,of
R5961	T9062	T9063	punct	(,e
R5962	T9063	T9046	parataxis	e,traced
R5963	T9064	T9063	nmod	c,e
R5964	T9065	T9063	punct	", ",e
R5965	T9066	T9063	punct	),e
R5966	T9067	T9046	punct	.,traced
R5967	T9069	T9070	det	The,apex
R5968	T9070	T9071	nsubj	apex,shows
R5969	T9072	T9073	amod	little,change
R597	T1142	T1138	nsubj	loss,suggests
R5970	T9073	T9071	dobj	change,shows
R5971	T9074	T9071	punct	", ",shows
R5972	T9075	T9071	prep	except,shows
R5973	T9076	T9075	prep	for,except
R5974	T9077	T9078	det	the,absence
R5975	T9078	T9076	pobj	absence,for
R5976	T9079	T9078	prep	of,absence
R5977	T9080	T9079	pobj	fibers,of
R5978	T9081	T9080	prep	to,fibers
R5979	T9082	T9083	det	the,area
R598	T1143	T1142	amod	selective,loss
R5980	T9083	T9081	pobj	area,to
R5981	T9084	T9083	prep	of,area
R5982	T9085	T9086	amod	outer,cells
R5983	T9086	T9084	pobj	cells,of
R5984	T9087	T9086	compound	hair,cells
R5985	T9088	T9078	cc	and,absence
R5986	T9089	T9090	det	the,formation
R5987	T9090	T9078	conj	formation,absence
R5988	T9091	T9090	prep	of,formation
R5989	T9092	T9093	amod	inner,bundles
R599	T1144	T1142	prep	of,loss
R5990	T9093	T9091	pobj	bundles,of
R5991	T9094	T9093	amod	spiral,bundles
R5992	T9095	T9093	acl	passing,bundles
R5993	T9096	T9095	prep	along,passing
R5994	T9097	T9098	det	the,cells
R5995	T9098	T9096	pobj	cells,along
R5996	T9099	T9098	amod	few,cells
R5997	T9100	T9098	amod	immature,cells
R5998	T9101	T9098	compound	hair,cells
R5999	T9102	T9103	punct	(,g
R6	T193	T194	amod	long,term
R60	T256	T255	aux	have,investigated
R600	T1145	T1144	pobj	vestibular,of
R6000	T9103	T9071	parataxis	g,shows
R6001	T9104	T9103	nmod	d,g
R6002	T9105	T9103	punct	",",g
R6003	T9106	T9103	nmod	f,g
R6004	T9107	T9103	punct	",",g
R6005	T9108	T9103	punct	),g
R6006	T9109	T9071	punct	.,shows
R6007	T9111	T9112	det	The,pattern
R6008	T9112	T9113	nsubj	pattern,is
R6009	T9114	T9112	acl	obtained,pattern
R601	T1146	T1145	prep	as,vestibular
R6010	T9115	T9114	prep	with,obtained
R6011	T9116	T9117	compound	DiI,tracing
R6012	T9117	T9115	pobj	tracing,with
R6013	T9118	T9113	acomp	identical,is
R6014	T9119	T9118	prep	to,identical
R6015	T9120	T9119	pobj	that,to
R6016	T9121	T9120	acl	obtained,that
R6017	T9122	T9121	prep	by,obtained
R6018	T9123	T9124	amod	acetylated,tubulin
R6019	T9124	T9125	compound	tubulin,immunoreactivity
R602	T1147	T1146	prep	compared,as
R6020	T9125	T9122	pobj	immunoreactivity,by
R6021	T9126	T9127	punct	(,g
R6022	T9127	T9113	parataxis	g,is
R6023	T9128	T9127	nmod	f,g
R6024	T9129	T9127	punct	",",g
R6025	T9130	T9127	punct	),g
R6026	T9131	T9113	punct	.,is
R6027	T9133	T9134	nsubj	Bar,indicates
R6028	T9135	T9136	nummod	1000,μm
R6029	T9136	T9134	dobj	μm,indicates
R603	T1148	T1147	prep	to,compared
R6030	T9137	T9134	prep	in,indicates
R6031	T9138	T9137	pobj	a,in
R6032	T9139	T9134	punct	", ",indicates
R6033	T9140	T9141	nummod	100,μm
R6034	T9141	T9134	dep	μm,indicates
R6035	T9142	T9141	prep	in,μm
R6036	T9143	T9142	pobj	b,in
R6037	T9144	T9145	punct	-,g
R6038	T9145	T9143	prep	g,b
R6039	T9146	T9134	punct	.,indicates
R604	T1149	T1148	pobj	cochlear,to
R6048	T9258	T9259	det	The,distribution
R6049	T9259	T9260	nsubjpass	distribution,shown
R605	T1150	T1151	amod	sensory,neurons
R6050	T9261	T9259	prep	of,distribution
R6051	T9262	T9263	compound	hair,cells
R6052	T9263	T9261	pobj	cells,of
R6053	T9264	T9265	mark	as,identified
R6054	T9265	T9259	advcl	identified,distribution
R6055	T9266	T9265	prep	with,identified
R6056	T9267	T9268	compound	MyoVII,immunocytochemistry
R6057	T9268	T9266	pobj	immunocytochemistry,with
R6058	T9269	T9260	auxpass	is,shown
R6059	T9270	T9260	prep	for,shown
R606	T1151	T1145	appos	neurons,vestibular
R6060	T9271	T9272	amod	7,day
R6061	T9272	T9274	amod	day,old
R6062	T9273	T9272	punct	-,day
R6063	T9274	T9275	amod	old,cochlea
R6064	T9275	T9270	pobj	cochlea,for
R6065	T9276	T9277	amod	whole,mounted
R6066	T9277	T9275	amod	mounted,cochlea
R6067	T9278	T9279	punct	(,a
R6068	T9279	T9260	parataxis	a,shown
R6069	T9280	T9281	punct	-,d
R607	T1152	T1153	punct	(,%
R6070	T9281	T9279	prep	d,a
R6071	T9282	T9279	punct	),a
R6072	T9283	T9260	cc	and,shown
R6073	T9284	T9285	det	the,appearance
R6074	T9285	T9286	nsubjpass	appearance,shown
R6075	T9286	T9260	conj	shown,shown
R6076	T9287	T9285	prep	of,appearance
R6077	T9288	T9289	amod	cytological,differentiation
R6078	T9289	T9287	pobj	differentiation,of
R6079	T9290	T9286	auxpass	is,shown
R608	T1153	T1145	parataxis	%,vestibular
R6080	T9291	T9292	mark	as,revealed
R6081	T9292	T9286	advcl	revealed,shown
R6082	T9293	T9292	prep	with,revealed
R6083	T9294	T9295	compound	epoxy,resin
R6084	T9295	T9296	compound	resin,sections
R6085	T9296	T9293	pobj	sections,with
R6086	T9297	T9296	prep	in,sections
R6087	T9298	T9299	nummod	7,day
R6088	T9299	T9301	npadvmod	day,old
R6089	T9300	T9299	punct	-,day
R609	T1154	T1153	nummod	77,%
R6090	T9301	T9302	amod	old,cochleae
R6091	T9302	T9297	pobj	cochleae,in
R6092	T9303	T9304	punct	(,e
R6093	T9304	T9301	parataxis	e,old
R6094	T9305	T9306	punct	-,g
R6095	T9306	T9304	prep	g,e
R6096	T9307	T9304	punct	),e
R6097	T9308	T9301	cc	and,old
R6098	T9309	T9310	nummod	6,month
R6099	T9310	T9312	npadvmod	month,old
R61	T257	T255	advmod	therefore,investigated
R610	T1155	T1153	cc	versus,%
R6100	T9311	T9310	punct	-,month
R6101	T9312	T9313	amod	old,control
R6102	T9313	T9301	conj	control,old
R6103	T9314	T9315	punct	(,h
R6104	T9315	T9312	parataxis	h,old
R6105	T9316	T9315	punct	),h
R6106	T9317	T9318	punct	(,e
R6107	T9318	T9313	parataxis	e,control
R6108	T9319	T9318	nmod	a,e
R6109	T9320	T9318	punct	",",e
R611	T1156	T1157	nummod	29,%
R6110	T9321	T9318	nmod	c,e
R6111	T9322	T9318	punct	",",e
R6112	T9323	T9318	punct	),e
R6113	T9324	T9313	cc	and,control
R6114	T9325	T9326	npadvmod	Brn3c,mutant
R6115	T9326	T9313	conj	mutant,control
R6116	T9327	T9328	punct	(,b
R6117	T9328	T9302	parataxis	b,cochleae
R6118	T9329	T9328	punct	",",b
R6119	T9330	T9328	appos	d,b
R612	T1157	T1153	conj	%,%
R6120	T9331	T9328	punct	",",b
R6121	T9332	T9328	appos	f,b
R6122	T9333	T9334	punct	-,h
R6123	T9334	T9332	prep	h,f
R6124	T9335	T9328	punct	),b
R6125	T9336	T9286	punct	.,shown
R6126	T9339	T9340	det	the,staining
R6127	T9340	T9338	dobj	staining,Note
R6128	T9341	T9340	amod	uniform,staining
R6129	T9342	T9340	prep	with,staining
R613	T1158	T1153	punct	;,%
R6130	T9343	T9344	det	this,antibody
R6131	T9344	T9342	pobj	antibody,with
R6132	T9345	T9340	prep	of,staining
R6133	T9346	T9347	det	all,rows
R6134	T9347	T9345	pobj	rows,of
R6135	T9348	T9347	nummod	three,rows
R6136	T9349	T9347	prep	of,rows
R6137	T9350	T9351	amod	outer,cells
R6138	T9351	T9349	pobj	cells,of
R6139	T9352	T9351	compound	hair,cells
R614	T1159	T1160	punct	[,3
R6140	T9353	T9351	punct	(,cells
R6141	T9354	T9351	appos	OHC,cells
R6142	T9355	T9340	punct	),staining
R6143	T9356	T9340	cc	and,staining
R6144	T9357	T9358	det	the,row
R6145	T9358	T9340	conj	row,staining
R6146	T9359	T9358	amod	single,row
R6147	T9360	T9358	prep	of,row
R6148	T9361	T9362	amod	inner,cells
R6149	T9362	T9360	pobj	cells,of
R615	T1160	T1153	parataxis	3,%
R6150	T9363	T9362	compound	hair,cells
R6151	T9364	T9362	punct	(,cells
R6152	T9365	T9362	appos	IHC,cells
R6153	T9366	T9358	punct	),row
R6154	T9367	T9358	prep	in,row
R6155	T9368	T9369	det	the,wildtype
R6156	T9369	T9367	pobj	wildtype,in
R6157	T9370	T9371	punct	(,c
R6158	T9371	T9338	parataxis	c,Note
R6159	T9372	T9371	nmod	a,c
R616	T1161	T1160	punct	],3
R6160	T9373	T9371	punct	",",c
R6161	T9374	T9371	punct	),c
R6162	T9375	T9338	punct	.,Note
R6163	T9377	T9378	prep	In,found
R6164	T9379	T9377	pobj	contrast,In
R6165	T9380	T9378	punct	", ",found
R6166	T9381	T9382	advmod	only,cells
R6167	T9382	T9378	nsubjpass	cells,found
R6168	T9383	T9382	amod	few,cells
R6169	T9384	T9382	amod	immature,cells
R617	T1162	T1153	punct	),%
R6170	T9385	T9382	compound	hair,cells
R6171	T9386	T9382	punct	(,cells
R6172	T9387	T9382	appos	iHC,cells
R6173	T9388	T9378	punct	),found
R6174	T9389	T9378	auxpass	are,found
R6175	T9390	T9378	prep	in,found
R6176	T9391	T9392	det	the,turn
R6177	T9392	T9390	pobj	turn,in
R6178	T9393	T9392	amod	basal,turn
R6179	T9394	T9392	prep	of,turn
R618	T1163	T1164	mark	that,be
R6180	T9395	T9396	det	the,littermate
R6181	T9396	T9394	pobj	littermate,of
R6182	T9397	T9396	amod	mutant,littermate
R6183	T9398	T9399	punct	(,b
R6184	T9399	T9378	parataxis	b,found
R6185	T9400	T9399	punct	),b
R6186	T9401	T9378	cc	and,found
R6187	T9402	T9403	advmod	only,cell
R6188	T9403	T9406	nsubj	cell,is
R6189	T9404	T9403	det	an,cell
R619	T1164	T1138	ccomp	be,suggests
R6190	T9405	T9403	amod	occasional,cell
R6191	T9406	T9378	conj	is,found
R6192	T9407	T9408	npadvmod	MyoVII,immunopositive
R6193	T9408	T9406	acomp	immunopositive,is
R6194	T9409	T9406	prep	in,is
R6195	T9410	T9411	det	the,turn
R6196	T9411	T9409	pobj	turn,in
R6197	T9412	T9411	amod	middle,turn
R6198	T9413	T9414	punct	(,d
R6199	T9414	T9406	parataxis	d,is
R62	T258	T255	prep	in,investigated
R620	T1165	T1166	nmod	NT,expression
R6200	T9415	T9414	punct	),d
R6201	T9416	T9378	punct	.,found
R6202	T9418	T9419	det	No,cells
R6203	T9419	T9424	nsubj	cells,exist
R6204	T9420	T9421	npadvmod	MyoVII,positive
R6205	T9421	T9419	amod	positive,cells
R6206	T9422	T9419	amod	immature,cells
R6207	T9423	T9419	compound	hair,cells
R6208	T9425	T9424	prep	in,exist
R6209	T9426	T9427	det	the,apex
R621	T1166	T1164	nsubj	expression,be
R6210	T9427	T9425	pobj	apex,in
R6211	T9428	T9424	punct	.,exist
R6212	T9430	T9431	nsubj	Sections,show
R6213	T9432	T9433	det	the,degree
R6214	T9433	T9431	dobj	degree,show
R6215	T9434	T9433	prep	of,degree
R6216	T9435	T9434	pobj	differentiation,of
R6217	T9436	T9435	prep	of,differentiation
R6218	T9437	T9438	compound	hair,cells
R6219	T9438	T9436	pobj	cells,of
R622	T1167	T1165	punct	-,NT
R6220	T9439	T9433	cc	and,degree
R6221	T9440	T9441	poss	their,fibers
R6222	T9441	T9433	conj	fibers,degree
R6223	T9442	T9441	amod	innervating,fibers
R6224	T9443	T9441	acl	stained,fibers
R6225	T9444	T9443	prep	with,stained
R6226	T9445	T9446	compound	tubulin,immunocytochemistry
R6227	T9446	T9444	pobj	immunocytochemistry,with
R6228	T9447	T9448	punct	(,arrow
R6229	T9448	T9431	parataxis	arrow,show
R623	T1168	T1165	nummod	3,NT
R6230	T9449	T9448	punct	;,arrow
R6231	T9450	T9448	appos	e,arrow
R6232	T9451	T9452	punct	-,h
R6233	T9452	T9450	prep	h,e
R6234	T9453	T9448	punct	),arrow
R6235	T9454	T9431	punct	.,show
R6236	T9457	T9458	det	the,presence
R6237	T9458	T9456	dobj	presence,Note
R6238	T9459	T9458	prep	of,presence
R6239	T9460	T9461	det	a,capillary
R624	T1169	T1164	aux	may,be
R6240	T9461	T9459	pobj	capillary,of
R6241	T9462	T9461	amod	spiral,capillary
R6242	T9463	T9464	punct	(,C
R6243	T9464	T9461	parataxis	C,capillary
R6244	T9465	T9464	punct	),C
R6245	T9466	T9458	prep	under,presence
R6246	T9467	T9468	det	the,tunnel
R6247	T9468	T9466	pobj	tunnel,under
R6248	T9469	T9468	prep	of,tunnel
R6249	T9470	T9469	pobj	Corti,of
R625	T1170	T1171	advmod	less,downregulated
R6250	T9471	T9458	acl	separating,presence
R6251	T9472	T9473	det	the,cells
R6252	T9473	T9471	dobj	cells,separating
R6253	T9474	T9473	amod	inner,cells
R6254	T9475	T9474	cc	and,inner
R6255	T9476	T9474	conj	outer,inner
R6256	T9477	T9473	compound	hair,cells
R6257	T9478	T9473	prep	in,cells
R6258	T9479	T9480	det	the,wildtype
R6259	T9480	T9478	pobj	wildtype,in
R626	T1171	T1164	acomp	downregulated,be
R6260	T9481	T9480	compound	P7,wildtype
R6261	T9482	T9483	punct	(,e
R6262	T9483	T9471	parataxis	e,separating
R6263	T9484	T9483	punct	),e
R6264	T9485	T9456	punct	.,Note
R6265	T9487	T9488	prep	In,is
R6266	T9489	T9487	pobj	contrast,In
R6267	T9490	T9488	punct	", ",is
R6268	T9491	T9492	det	no,capillary
R6269	T9492	T9488	nsubj	capillary,is
R627	T1172	T1164	prep	in,be
R6270	T9493	T9492	amod	such,capillary
R6271	T9494	T9488	acomp	present,is
R6272	T9495	T9488	prep	underneath,is
R6273	T9496	T9497	det	the,organ
R6274	T9497	T9495	pobj	organ,underneath
R6275	T9498	T9497	prep	of,organ
R6276	T9499	T9498	pobj	Corti,of
R6277	T9500	T9488	prep	in,is
R6278	T9501	T9500	pobj	mutants,in
R6279	T9502	T9503	punct	(,f
R628	T1173	T1174	nmod	Brn3c,mutants
R6280	T9503	T9488	parataxis	f,is
R6281	T9504	T9505	punct	-,h
R6282	T9505	T9503	prep	h,f
R6283	T9506	T9503	punct	),f
R6284	T9507	T9488	cc	and,is
R6285	T9508	T9509	det	no,tunnel
R6286	T9509	T9510	nsubjpass	tunnel,found
R6287	T9510	T9488	conj	found,is
R6288	T9511	T9509	prep	of,tunnel
R6289	T9512	T9511	pobj	Corti,of
R629	T1174	T1172	pobj	mutants,in
R6290	T9513	T9510	auxpass	is,found
R6291	T9514	T9510	advmod	either,found
R6292	T9515	T9488	punct	.,is
R6293	T9517	T9518	det	A,membrane
R6294	T9518	T9520	nsubj	membrane,forms
R6295	T9519	T9518	amod	tectorial,membrane
R6296	T9521	T9520	punct	(,forms
R6297	T9522	T9520	dobj	TM,forms
R6298	T9523	T9520	punct	),forms
R6299	T9524	T9520	cc	but,forms
R63	T259	T260	det	these,mutants
R630	T1175	T1174	amod	null,mutants
R6300	T9525	T9526	advmod	otherwise,is
R6301	T9526	T9520	conj	is,forms
R6302	T9527	T9526	expl	there,is
R6303	T9528	T9529	amod	little,differentiation
R6304	T9529	T9526	attr	differentiation,is
R6305	T9530	T9529	amod	cyotological,differentiation
R6306	T9531	T9526	punct	.,is
R6307	T9534	T9535	mark	that,traced
R6308	T9535	T9533	ccomp	traced,Note
R6309	T9536	T9537	amod	tubulin,positive
R631	T1176	T1164	prep	than,be
R6310	T9537	T9539	amod	positive,fibers
R6311	T9538	T9537	punct	-,positive
R6312	T9539	T9535	nsubjpass	fibers,traced
R6313	T9540	T9535	aux	can,traced
R6314	T9541	T9535	auxpass	be,traced
R6315	T9542	T9535	prep	to,traced
R6316	T9543	T9544	det	the,cells
R6317	T9544	T9542	pobj	cells,to
R6318	T9545	T9544	amod	immature,cells
R6319	T9546	T9535	prep	until,traced
R632	T1177	T1176	pobj	BDNF,than
R6320	T9547	T9548	nummod	6,months
R6321	T9548	T9546	pobj	months,until
R6322	T9549	T9550	punct	(,h
R6323	T9550	T9533	parataxis	h,Note
R6324	T9551	T9550	punct	),h
R6325	T9552	T9533	punct	.,Note
R6326	T9554	T9555	nsubj	Bar,indicates
R6327	T9556	T9554	prep	in,Bar
R6328	T9557	T9556	pobj	c,in
R6329	T9558	T9559	nummod	100,μm
R633	T1178	T1179	punct	[,9
R6330	T9559	T9555	dobj	μm,indicates
R6331	T9560	T9555	punct	.,indicates
R6334	T9610	T9611	det	This,graph
R6335	T9611	T9612	nsubj	graph,shows
R6336	T9613	T9614	det	the,reduction
R6337	T9614	T9612	dobj	reduction,shows
R6338	T9615	T9614	prep	in,reduction
R6339	T9616	T9617	amod	sensory,neurons
R634	T1179	T1164	parataxis	9,be
R6340	T9617	T9615	pobj	neurons,in
R6341	T9618	T9619	punct	(,top
R6342	T9619	T9617	parataxis	top,neurons
R6343	T9620	T9619	punct	),top
R6344	T9621	T9615	cc	and,in
R6345	T9622	T9615	conj	in,in
R6346	T9623	T9624	compound	hair,cells
R6347	T9624	T9622	pobj	cells,in
R6348	T9625	T9626	punct	(,bottom
R6349	T9626	T9624	parataxis	bottom,cells
R635	T1180	T1179	nummod	6,9
R6350	T9627	T9626	punct	),bottom
R6351	T9628	T9614	prep	between,reduction
R6352	T9629	T9630	amod	7,day
R6353	T9630	T9632	amod	day,old
R6354	T9631	T9630	punct	-,day
R6355	T9632	T9633	amod	old,wildtype
R6356	T9633	T9634	nmod	wildtype,littermates
R6357	T9634	T9628	pobj	littermates,between
R6358	T9635	T9633	cc	and,wildtype
R6359	T9636	T9637	npadvmod	Brn3c,null
R636	T1181	T1179	punct	",",9
R6360	T9637	T9633	conj	null,wildtype
R6361	T9638	T9634	amod	mutant,littermates
R6362	T9639	T9612	punct	.,shows
R6363	T9642	T9643	det	the,reduction
R6364	T9643	T9641	dobj	reduction,Note
R6365	T9644	T9643	amod	sharp,reduction
R6366	T9645	T9643	prep	to,reduction
R6367	T9646	T9647	nummod	1,%
R6368	T9647	T9645	pobj	%,to
R6369	T9648	T9643	prep	in,reduction
R637	T1182	T1179	nummod	8,9
R6370	T9649	T9650	det	the,cells
R6371	T9650	T9648	pobj	cells,in
R6372	T9651	T9650	amod	cochlear,cells
R6373	T9652	T9650	amod	immature,cells
R6374	T9653	T9650	compound	hair,cells
R6375	T9654	T9655	punct	(,bottom
R6376	T9655	T9643	parataxis	bottom,reduction
R6377	T9656	T9655	punct	),bottom
R6378	T9657	T9658	mark	whereas,reduced
R6379	T9658	T9641	advcl	reduced,Note
R638	T1183	T1179	punct	",",9
R6380	T9659	T9660	amod	spiral,neurons
R6381	T9660	T9658	nsubjpass	neurons,reduced
R6382	T9661	T9660	amod	sensory,neurons
R6383	T9662	T9660	punct	(,neurons
R6384	T9663	T9660	appos	SG,neurons
R6385	T9664	T9658	punct	),reduced
R6386	T9665	T9658	auxpass	are,reduced
R6387	T9666	T9658	advmod	only,reduced
R6388	T9667	T9658	prep	by,reduced
R6389	T9668	T9669	nummod	50,%
R639	T1184	T1179	punct	],9
R6390	T9669	T9667	pobj	%,by
R6391	T9670	T9671	punct	(,top
R6392	T9671	T9658	parataxis	top,reduced
R6393	T9672	T9671	punct	),top
R6394	T9673	T9641	punct	.,Note
R6395	T9675	T9676	prep	In,identified
R6396	T9677	T9675	pobj	contrast,In
R6397	T9678	T9676	punct	", ",identified
R6398	T9679	T9680	nummod	20,%
R6399	T9680	T9681	nmod	%,cells
R64	T260	T258	pobj	mutants,in
R640	T1185	T1164	punct	", ",be
R6400	T9681	T9676	nsubjpass	cells,identified
R6401	T9682	T9681	amod	immature,cells
R6402	T9683	T9681	compound	hair,cells
R6403	T9684	T9676	aux	could,identified
R6404	T9685	T9676	auxpass	be,identified
R6405	T9686	T9676	prep	in,identified
R6406	T9687	T9688	amod	vestibular,epithelia
R6407	T9688	T9686	pobj	epithelia,in
R6408	T9689	T9688	amod	sensory,epithelia
R6409	T9690	T9691	punct	(,bottom
R641	T1186	T1164	prep	provided,be
R6410	T9691	T9676	parataxis	bottom,identified
R6411	T9692	T9693	nsubjpass	saccule,selected
R6412	T9693	T9691	ccomp	selected,bottom
R6413	T9694	T9693	aux	has,selected
R6414	T9695	T9693	auxpass	been,selected
R6415	T9696	T9691	punct	;,bottom
R6416	T9697	T9691	punct	),bottom
R6417	T9698	T9699	mark	whereas,survive
R6418	T9699	T9676	advcl	survive,identified
R6419	T9700	T9701	advmod	only,15
R642	T1187	T1188	mark	that,takes
R6420	T9701	T9703	nummod	15,%
R6421	T9702	T9701	quantmod	around,15
R6422	T9703	T9699	nsubj	%,survive
R6423	T9704	T9703	prep	of,%
R6424	T9705	T9706	det	the,neurons
R6425	T9706	T9704	pobj	neurons,of
R6426	T9707	T9706	amod	vestibular,neurons
R6427	T9708	T9706	amod	sensory,neurons
R6428	T9709	T9699	prep	to,survive
R6429	T9710	T9711	det	this,age
R643	T1188	T1186	pcomp	takes,provided
R6430	T9711	T9709	pobj	age,to
R6431	T9712	T9713	punct	(,top
R6432	T9713	T9699	parataxis	top,survive
R6433	T9714	T9713	dep	VG,top
R6434	T9715	T9713	punct	;,top
R6435	T9716	T9713	punct	),top
R6436	T9717	T9676	punct	.,identified
R6437	T9719	T9720	prep	For,see
R6438	T9721	T9719	pobj	details,For
R6439	T9722	T9721	prep	on,details
R644	T1189	T1190	advmod	at,least
R6440	T9723	T9724	det	the,data
R6441	T9724	T9722	pobj	data,on
R6442	T9725	T9720	dobj	Table,see
R6443	T9726	T9725	nummod	1,Table
R6444	T9727	T9720	punct	.,see
R6447	T9768	T9769	det	These,images
R6448	T9769	T9771	nsubj	images,show
R6449	T9770	T9769	amod	confocal,images
R645	T1190	T1191	advmod	least,differentiation
R6450	T9772	T9773	det	the,pattern
R6451	T9773	T9771	dobj	pattern,show
R6452	T9774	T9773	compound	projection,pattern
R6453	T9775	T9773	prep	of,pattern
R6454	T9776	T9777	det	a,mouse
R6455	T9777	T9775	pobj	mouse,of
R6456	T9778	T9777	nmod	P8,mouse
R6457	T9779	T9777	nmod	Brn3c,mouse
R6458	T9780	T9777	amod	null,mouse
R6459	T9781	T9777	amod	mutant,mouse
R646	T1191	T1188	nsubj	differentiation,takes
R6460	T9782	T9771	punct	.,show
R6461	T9784	T9785	nsubjpass	DiI,inserted
R6462	T9785	T9790	ccomp	inserted,inserted
R6463	T9786	T9787	punct	(,red
R6464	T9787	T9784	parataxis	red,DiI
R6465	T9788	T9787	punct	),red
R6466	T9789	T9785	auxpass	was,inserted
R6467	T9791	T9785	prep	into,inserted
R6468	T9792	T9793	det	the,turn
R6469	T9793	T9791	pobj	turn,into
R647	T1192	T1191	det	some,differentiation
R6470	T9794	T9793	amod	basal,turn
R6471	T9795	T9790	punct	", ",inserted
R6472	T9796	T9790	nsubjpass	DiA,inserted
R6473	T9797	T9798	punct	(,green
R6474	T9798	T9796	parataxis	green,DiA
R6475	T9799	T9798	punct	),green
R6476	T9800	T9790	auxpass	was,inserted
R6477	T9801	T9790	prep	into,inserted
R6478	T9802	T9803	det	the,turn
R6479	T9803	T9801	pobj	turn,into
R648	T1193	T1191	prep	of,differentiation
R6480	T9804	T9803	amod	apical,turn
R6481	T9805	T9790	punct	.,inserted
R6482	T9808	T9809	mark	that,run
R6483	T9809	T9807	ccomp	run,Note
R6484	T9810	T9811	det	the,fibers
R6485	T9811	T9809	nsubj	fibers,run
R6486	T9812	T9809	prep	in,run
R6487	T9813	T9814	amod	discrete,bundles
R6488	T9814	T9812	pobj	bundles,in
R6489	T9815	T9809	prep	inside,run
R649	T1194	T1195	amod	supporting,cells
R6490	T9816	T9817	det	the,nerve
R6491	T9817	T9815	pobj	nerve,inside
R6492	T9818	T9817	amod	cochlear,nerve
R6493	T9819	T9820	punct	(,a
R6494	T9820	T9809	parataxis	a,run
R6495	T9821	T9820	punct	),a
R6496	T9822	T9809	punct	", ",run
R6497	T9823	T9809	conj	spiral,run
R6498	T9824	T9823	prep	around,spiral
R6499	T9825	T9826	det	each,other
R65	T261	T262	det	the,patterns
R650	T1195	T1193	pobj	cells,of
R6500	T9826	T9824	pobj	other,around
R6501	T9827	T9823	prep	near,spiral
R6502	T9828	T9829	det	the,root
R6503	T9829	T9827	pobj	root,near
R6504	T9830	T9823	cc	and,spiral
R6505	T9831	T9823	conj	project,spiral
R6506	T9832	T9831	prep	to,project
R6507	T9833	T9834	amod	distinct,divisions
R6508	T9834	T9832	pobj	divisions,to
R6509	T9835	T9834	amod	medial,divisions
R651	T1196	T1188	dobj	place,takes
R6510	T9836	T9835	cc	and,medial
R6511	T9837	T9835	conj	lateral,medial
R6512	T9838	T9834	prep	of,divisions
R6513	T9839	T9840	det	the,nucleus
R6514	T9840	T9838	pobj	nucleus,of
R6515	T9841	T9840	amod	ventral,nucleus
R6516	T9842	T9840	amod	cochlear,nucleus
R6517	T9843	T9844	punct	(,b
R6518	T9844	T9831	parataxis	b,project
R6519	T9845	T9844	punct	),b
R652	T1197	T1138	punct	.,suggests
R6520	T9846	T9807	punct	.,Note
R6521	T9848	T9849	det	These,data
R6522	T9849	T9850	nsubj	data,suggest
R6523	T9851	T9852	mark	that,form
R6524	T9852	T9850	ccomp	form,suggest
R6525	T9853	T9854	det	a,projection
R6526	T9854	T9852	nsubj	projection,form
R6527	T9855	T9854	amod	crude,projection
R6528	T9856	T9854	amod	cochleotopic,projection
R6529	T9857	T9852	aux	can,form
R653	T1199	T1200	prep	In,downregulated
R6530	T9858	T9852	advmod	independently,form
R6531	T9859	T9858	prep	of,independently
R6532	T9860	T9861	det	any,signaling
R6533	T9861	T9859	pobj	signaling,of
R6534	T9862	T9861	prep	from,signaling
R6535	T9863	T9864	det	the,cells
R6536	T9864	T9862	pobj	cells,from
R6537	T9865	T9864	amod	immature,cells
R6538	T9866	T9864	compound	hair,cells
R6539	T9867	T9864	prep	of,cells
R654	T1201	T1202	det	the,ear
R6540	T9868	T9869	det	the,cochlea
R6541	T9869	T9867	pobj	cochlea,of
R6542	T9870	T9850	punct	.,suggest
R6543	T9872	T9873	nsubj	Arrow,indicates
R6544	T9874	T9875	det	the,bundle
R6545	T9875	T9873	dobj	bundle,indicates
R6546	T9876	T9875	amod	efferent,bundle
R6547	T9877	T9878	mark	as,leaves
R6548	T9878	T9873	advcl	leaves,indicates
R6549	T9879	T9878	nsubj	it,leaves
R655	T1202	T1199	pobj	ear,In
R6550	T9880	T9881	det	the,tract
R6551	T9881	T9878	dobj	tract,leaves
R6552	T9882	T9881	amod	afferent,tract
R6553	T9883	T9881	compound	fiber,tract
R6554	T9884	T9873	punct	.,indicates
R6555	T9886	T9887	nsubj	Bar,indicates
R6556	T9888	T9889	nummod	100,μm
R6557	T9889	T9887	dobj	μm,indicates
R6558	T9890	T9887	punct	.,indicates
R656	T1203	T1204	punct	[,4
R6561	T9944	T9945	det	The,innervation
R6562	T9945	T9946	nsubjpass	innervation,shown
R6563	T9947	T9945	prep	of,innervation
R6564	T9948	T9949	amod	sensory,epithelia
R6565	T9949	T9947	pobj	epithelia,of
R6566	T9950	T9946	auxpass	is,shown
R6567	T9951	T9946	prep	in,shown
R6568	T9952	T9953	amod	6,month
R6569	T9953	T9955	amod	month,old
R657	T1204	T1199	parataxis	4,In
R6570	T9954	T9953	punct	-,month
R6571	T9955	T9956	amod	old,mice
R6572	T9956	T9951	pobj	mice,in
R6573	T9957	T9956	nmod	Brn3c,mice
R6574	T9958	T9956	amod	null,mice
R6575	T9959	T9956	amod	mutant,mice
R6576	T9960	T9946	punct	.,shown
R6577	T9962	T9963	prep	Compared,is
R6578	T9964	T9962	prep	to,Compared
R6579	T9965	T9966	compound	P8,animals
R658	T1205	T1204	punct	],4
R6580	T9966	T9964	pobj	animals,to
R6581	T9967	T9963	expl	there,is
R6582	T9968	T9969	det	a,reduction
R6583	T9969	T9963	attr	reduction,is
R6584	T9970	T9969	amod	further,reduction
R6585	T9971	T9969	prep	of,reduction
R6586	T9972	T9973	compound	fiber,density
R6587	T9973	T9971	pobj	density,of
R6588	T9974	T9973	prep	to,density
R6589	T9975	T9976	amod	vestibular,epithelia
R659	T1206	T1207	advmod	as,as
R6590	T9976	T9974	pobj	epithelia,to
R6591	T9977	T9976	amod	sensory,epithelia
R6592	T9978	T9963	punct	", ",is
R6593	T9979	T9963	cc	but,is
R6594	T9980	T9981	nsubjpass	fibers,traced
R6595	T9981	T9963	conj	traced,is
R6596	T9982	T9981	aux	can,traced
R6597	T9983	T9981	auxpass	be,traced
R6598	T9984	T9981	prep	to,traced
R6599	T9985	T9986	det	all,epithelia
R66	T262	T255	dobj	patterns,investigated
R660	T1207	T1199	cc	as,In
R6600	T9986	T9984	pobj	epithelia,to
R6601	T9987	T9986	amod	sensory,epithelia
R6602	T9988	T9989	punct	(,b
R6603	T9989	T9981	parataxis	b,traced
R6604	T9990	T9989	nmod	a,b
R6605	T9991	T9989	punct	",",b
R6606	T9992	T9989	punct	),b
R6607	T9993	T9981	punct	.,traced
R6608	T9995	T9996	amod	Transcellular,labeling
R6609	T9996	T9997	nsubj	labeling,suggest
R661	T1208	T1207	advmod	well,as
R6610	T9998	T9996	prep	with,labeling
R6611	T9999	T9998	pobj	DiI,with
R6612	T10000	T10001	punct	(,b
R6613	T10001	T9996	parataxis	b,labeling
R6614	T10002	T10001	punct	),b
R6615	T10003	T9997	dobj	contacts,suggest
R6616	T10004	T10003	prep	between,contacts
R6617	T10005	T10006	det	these,afferents
R6618	T10006	T10004	pobj	afferents,between
R6619	T10007	T10006	cc	and,afferents
R662	T1209	T1210	advmod	elsewhere,10
R6620	T10008	T10009	amod	immature,cells
R6621	T10009	T10006	conj	cells,afferents
R6622	T10010	T10009	compound	hair,cells
R6623	T10011	T9997	punct	.,suggest
R6624	T10013	T10014	det	The,cochlea
R6625	T10014	T10015	nsubj	cochlea,shows
R6626	T10016	T10017	det	a,density
R6627	T10017	T10015	dobj	density,shows
R6628	T10018	T10019	advmod	much,reduced
R6629	T10019	T10017	amod	reduced,density
R663	T1210	T1199	conj	10,In
R6630	T10020	T10017	prep	of,density
R6631	T10021	T10022	amod	radial,bundles
R6632	T10022	T10020	pobj	bundles,of
R6633	T10023	T10015	punct	", ",shows
R6634	T10024	T10025	advmod	even,in
R6635	T10025	T10015	prep	in,shows
R6636	T10026	T10027	det	the,apex
R6637	T10027	T10025	pobj	apex,in
R6638	T10028	T10029	punct	(,d
R6639	T10029	T10015	parataxis	d,shows
R664	T1211	T1210	punct	[,10
R6640	T10030	T10029	nmod	c,d
R6641	T10031	T10029	punct	",",d
R6642	T10032	T10029	punct	),d
R6643	T10033	T10015	punct	.,shows
R6644	T10035	T10036	advmod	However,are
R6645	T10037	T10036	punct	", ",are
R6646	T10038	T10039	amod	spiral,neurons
R6647	T10039	T10036	nsubj	neurons,are
R6648	T10040	T10039	amod	sensory,neurons
R6649	T10041	T10036	acomp	present,are
R665	T1212	T1210	punct	],10
R6650	T10042	T10036	prep	in,are
R6651	T10043	T10044	poss	Rosenthal,canal
R6652	T10044	T10042	pobj	canal,in
R6653	T10045	T10043	case	's,Rosenthal
R6654	T10046	T10047	punct	(,d
R6655	T10047	T10036	parataxis	d,are
R6656	T10048	T10047	nmod	c,d
R6657	T10049	T10047	punct	",",d
R6658	T10050	T10047	punct	),d
R6659	T10051	T10036	cc	and,are
R666	T1213	T1200	nsubjpass	neurotrophins,downregulated
R6660	T10052	T10053	nsubj	fibers,extend
R6661	T10053	T10036	conj	extend,are
R6662	T10054	T10053	prep	to,extend
R6663	T10055	T10056	det	the,organ
R6664	T10056	T10054	pobj	organ,to
R6665	T10057	T10056	prep	of,organ
R6666	T10058	T10057	pobj	Corti,of
R6667	T10059	T10060	advmod	where,form
R6668	T10060	T10056	relcl	form,organ
R6669	T10061	T10060	nsubj	they,form
R667	T1214	T1200	auxpass	are,downregulated
R6670	T10062	T10063	amod	longitudinal,tracts
R6671	T10063	T10060	dobj	tracts,form
R6672	T10064	T10060	prep	in,form
R6673	T10065	T10066	det	the,epithelium
R6674	T10066	T10064	pobj	epithelium,in
R6675	T10067	T10066	amod	immature,epithelium
R6676	T10068	T10036	punct	.,are
R6677	T10070	T10071	nsubj	Bar,indicates
R6678	T10072	T10073	nummod	100,μm
R6679	T10073	T10071	dobj	μm,indicates
R668	T1215	T1200	advmod	progressively,downregulated
R6680	T10074	T10071	punct	.,indicates
R6681	T10148	T10149	det	The,expression
R6682	T10149	T10150	nsubjpass	expression,shown
R6683	T10151	T10149	prep	of,expression
R6684	T10152	T10153	nmod	BDNF,mRNA
R6685	T10153	T10151	pobj	mRNA,of
R6686	T10154	T10152	cc	and,BDNF
R6687	T10155	T10152	conj	NT,BDNF
R6688	T10156	T10155	punct	-,NT
R6689	T10157	T10155	nummod	3,NT
R669	T1216	T1200	prep	in,downregulated
R6690	T10158	T10150	auxpass	is,shown
R6691	T10159	T10150	prep	in,shown
R6692	T10160	T10161	det	the,epithelia
R6693	T10161	T10159	pobj	epithelia,in
R6694	T10162	T10161	nmod	P0,epithelia
R6695	T10163	T10161	amod	vestibular,epithelia
R6696	T10164	T10161	amod	sensory,epithelia
R6697	T10165	T10150	punct	.,shown
R6698	T10167	T10168	compound	Silver,grains
R6699	T10168	T10169	nsubjpass	grains,colored
R67	T263	T262	prep	of,patterns
R670	T1217	T1218	amod	postnatal,mammals
R6700	T10170	T10169	auxpass	are,colored
R6701	T10171	T10169	amod	false,colored
R6702	T10172	T10169	prep	as,colored
R6703	T10173	T10172	pobj	red,as
R6704	T10174	T10175	aux	to,enhance
R6705	T10175	T10169	advcl	enhance,colored
R6706	T10176	T10175	dobj	visibility,enhance
R6707	T10177	T10175	prep	against,enhance
R6708	T10178	T10179	det	the,background
R6709	T10179	T10177	pobj	background,against
R671	T1218	T1216	pobj	mammals,in
R6710	T10180	T10179	amod	grey,background
R6711	T10181	T10182	npadvmod	Nissl,stained
R6712	T10182	T10179	amod	stained,background
R6713	T10183	T10182	punct	-,stained
R6714	T10184	T10169	punct	.,colored
R6715	T10186	T10187	amod	Canal,cristae
R6716	T10187	T10188	nsubj	cristae,contain
R6717	T10189	T10190	advmod	only,BDNF
R6718	T10190	T10188	dobj	BDNF,contain
R6719	T10191	T10192	punct	(,b
R672	T1219	T1200	cc	and,downregulated
R6720	T10192	T10188	parataxis	b,contain
R6721	T10193	T10192	nmod	a,b
R6722	T10194	T10192	punct	",",b
R6723	T10195	T10192	punct	),b
R6724	T10196	T10188	punct	", ",contain
R6725	T10197	T10188	cc	but,contain
R6726	T10198	T10199	amod	gravistatic,endorgans
R6727	T10199	T10200	nsubj	endorgans,contain
R6728	T10200	T10188	conj	contain,contain
R6729	T10201	T10199	punct	", ",endorgans
R673	T1220	T1221	advmod	possibly,replaced
R6730	T10202	T10203	amod	such,as
R6731	T10203	T10199	prep	as,endorgans
R6732	T10204	T10203	pobj	saccule,as
R6733	T10205	T10204	cc	and,saccule
R6734	T10206	T10204	conj	utricle,saccule
R6735	T10207	T10200	punct	", ",contain
R6736	T10208	T10209	preconj	both,BDNF
R6737	T10209	T10200	dobj	BDNF,contain
R6738	T10210	T10209	cc	and,BDNF
R6739	T10211	T10209	conj	NT,BDNF
R674	T1221	T1200	conj	replaced,downregulated
R6740	T10212	T10211	punct	-,NT
R6741	T10213	T10211	nummod	3,NT
R6742	T10214	T10215	punct	(,c
R6743	T10215	T10200	parataxis	c,contain
R6744	T10216	T10217	punct	-,f
R6745	T10217	T10215	prep	f,c
R6746	T10218	T10215	punct	),c
R6747	T10219	T10200	punct	.,contain
R6748	T10222	T10223	det	the,expression
R6749	T10223	T10221	dobj	expression,Note
R675	T1222	T1221	agent	by,replaced
R6750	T10224	T10223	amod	prominent,expression
R6751	T10225	T10223	compound	BDNF,expression
R6752	T10226	T10223	prep	in,expression
R6753	T10227	T10228	det	the,region
R6754	T10228	T10226	pobj	region,in
R6755	T10229	T10228	compound	hair,region
R6756	T10230	T10228	compound	cell,region
R6757	T10231	T10228	punct	(,region
R6758	T10232	T10228	appos	HaC,region
R6759	T10233	T10228	punct	),region
R676	T1223	T1224	amod	other,factors
R6760	T10234	T10228	prep	of,region
R6761	T10235	T10236	compound	control,canal
R6762	T10236	T10234	pobj	canal,of
R6763	T10237	T10238	punct	(,b
R6764	T10238	T10236	parataxis	b,canal
R6765	T10239	T10238	punct	),b
R6766	T10240	T10236	cc	and,canal
R6767	T10241	T10236	conj	saccule,canal
R6768	T10242	T10243	punct	(,d
R6769	T10243	T10241	parataxis	d,saccule
R677	T1224	T1222	pobj	factors,by
R6770	T10244	T10243	punct	),d
R6771	T10245	T10223	cc	and,expression
R6772	T10246	T10247	amod	low,levels
R6773	T10247	T10223	conj	levels,expression
R6774	T10248	T10247	prep	of,levels
R6775	T10249	T10248	pobj	expression,of
R6776	T10250	T10247	prep	in,levels
R6777	T10251	T10252	det	the,mice
R6778	T10252	T10250	pobj	mice,in
R6779	T10253	T10252	nmod	Brn3c,mice
R678	T1225	T1226	punct	[,11
R6780	T10254	T10252	amod	null,mice
R6781	T10255	T10256	punct	(,c
R6782	T10256	T10250	parataxis	c,in
R6783	T10257	T10256	nmod	a,c
R6784	T10258	T10256	punct	",",c
R6785	T10259	T10256	punct	),c
R6786	T10260	T10247	prep	over,levels
R6787	T10261	T10262	amod	immature,cells
R6788	T10262	T10260	pobj	cells,over
R6789	T10263	T10262	compound	hair,cells
R679	T1226	T1221	parataxis	11,replaced
R6790	T10264	T10262	punct	(,cells
R6791	T10265	T10262	appos	iHC,cells
R6792	T10266	T10221	punct	),Note
R6793	T10267	T10221	punct	.,Note
R6794	T10269	T10270	det	The,expression
R6795	T10270	T10274	nsubj	expression,is
R6796	T10271	T10270	nmod	NT,expression
R6797	T10272	T10271	punct	-,NT
R6798	T10273	T10271	nummod	3,NT
R6799	T10275	T10276	advmod	much,diffuse
R68	T264	T263	pobj	innervation,of
R680	T1227	T1226	punct	],11
R6800	T10276	T10274	acomp	diffuse,is
R6801	T10277	T10276	advmod	more,diffuse
R6802	T10278	T10274	prep	in,is
R6803	T10279	T10280	preconj	both,control
R6804	T10280	T10281	nmod	control,littermates
R6805	T10281	T10278	pobj	littermates,in
R6806	T10282	T10280	cc	and,control
R6807	T10283	T10280	conj	Brn3c,control
R6808	T10284	T10283	amod	mutant,Brn3c
R6809	T10285	T10274	punct	.,is
R681	T1228	T1200	punct	.,downregulated
R6810	T10287	T10288	nsubj	Bar,indicates
R6811	T10289	T10290	nummod	100,μm
R6812	T10290	T10288	dobj	μm,indicates
R6813	T10291	T10288	punct	.,indicates
R6814	T10350	T10351	nmod	BDNF,expression
R6815	T10351	T10357	nsubjpass	expression,shown
R6816	T10352	T10350	cc	and,BDNF
R6817	T10353	T10350	conj	NT,BDNF
R6818	T10354	T10353	punct	-,NT
R6819	T10355	T10353	nummod	3,NT
R682	T1230	T1231	nsubj	We,investigated
R6820	T10356	T10351	compound	mRNA,expression
R6821	T10358	T10357	auxpass	is,shown
R6822	T10359	T10357	prep	in,shown
R6823	T10360	T10361	det	the,cochlea
R6824	T10361	T10359	pobj	cochlea,in
R6825	T10362	T10361	prep	of,cochlea
R6826	T10363	T10364	nmod	P0,littermates
R6827	T10364	T10362	pobj	littermates,of
R6828	T10365	T10366	punct	(,a
R6829	T10366	T10363	parataxis	a,P0
R683	T1232	T1231	aux	have,investigated
R6830	T10367	T10368	punct	-,d
R6831	T10368	T10366	prep	d,a
R6832	T10369	T10366	punct	),a
R6833	T10370	T10363	cc	and,P0
R6834	T10371	T10363	conj	P8,P0
R6835	T10372	T10373	punct	(,f
R6836	T10373	T10371	parataxis	f,P8
R6837	T10374	T10373	nmod	e,f
R6838	T10375	T10373	punct	",",f
R6839	T10376	T10373	punct	),f
R684	T1233	T1231	prep	in,investigated
R6840	T10377	T10364	nmod	Brn3c,littermates
R6841	T10378	T10364	amod	null,littermates
R6842	T10379	T10378	cc	and,null
R6843	T10380	T10378	conj	control,null
R6844	T10381	T10357	punct	.,shown
R6845	T10384	T10385	det	the,expression
R6846	T10385	T10383	dobj	expression,Note
R6847	T10386	T10385	amod	limited,expression
R6848	T10387	T10385	prep	of,expression
R6849	T10388	T10387	pobj	BDNF,of
R685	T1234	T1233	pobj	detail,in
R6850	T10389	T10385	prep	in,expression
R6851	T10390	T10391	det	the,turn
R6852	T10391	T10389	pobj	turn,in
R6853	T10392	T10391	amod	basal,turn
R6854	T10393	T10391	prep	of,turn
R6855	T10394	T10395	preconj	both,wildtype
R6856	T10395	T10396	amod	wildtype,littermates
R6857	T10396	T10393	pobj	littermates,of
R6858	T10397	T10395	cc	and,wildtype
R6859	T10398	T10395	conj	mutant,wildtype
R686	T1235	T1236	det	the,pattern
R6860	T10399	T10400	punct	(,b
R6861	T10400	T10385	parataxis	b,expression
R6862	T10401	T10400	nmod	a,b
R6863	T10402	T10400	punct	",",b
R6864	T10403	T10400	punct	),b
R6865	T10404	T10385	cc	and,expression
R6866	T10405	T10406	det	the,expression
R6867	T10406	T10385	conj	expression,expression
R6868	T10407	T10408	advmod	much,stronger
R6869	T10408	T10406	amod	stronger,expression
R687	T1236	T1231	dobj	pattern,investigated
R6870	T10409	T10406	prep	of,expression
R6871	T10410	T10409	pobj	NT,of
R6872	T10411	T10410	punct	-,NT
R6873	T10412	T10410	nummod	3,NT
R6874	T10413	T10406	prep	in,expression
R6875	T10414	T10415	det	the,apex
R6876	T10415	T10413	pobj	apex,in
R6877	T10416	T10406	prep	over,expression
R6878	T10417	T10418	det	the,region
R6879	T10418	T10416	pobj	region,over
R688	T1237	T1236	prep	of,pattern
R6880	T10419	T10418	prep	of,region
R6881	T10420	T10421	det	the,cells
R6882	T10421	T10419	pobj	cells,of
R6883	T10422	T10421	amod	inner,cells
R6884	T10423	T10421	compound	hair,cells
R6885	T10424	T10406	prep	in,expression
R6886	T10425	T10426	preconj	both,wildtype
R6887	T10426	T10427	nmod	wildtype,littermates
R6888	T10427	T10424	pobj	littermates,in
R6889	T10428	T10426	cc	and,wildtype
R689	T1238	T1237	pobj	innervation,of
R6890	T10429	T10426	conj	control,wildtype
R6891	T10430	T10431	punct	(,d
R6892	T10431	T10406	parataxis	d,expression
R6893	T10432	T10431	nmod	c,d
R6894	T10433	T10431	punct	",",d
R6895	T10434	T10431	punct	),d
R6896	T10435	T10383	punct	.,Note
R6897	T10437	T10438	nmod	NT,expression
R6898	T10438	T10441	nsubj	expression,persists
R6899	T10439	T10437	punct	-,NT
R69	T265	T263	cc	and,of
R690	T1239	T1236	prep	in,pattern
R6900	T10440	T10437	nummod	3,NT
R6901	T10442	T10443	advmod	at,least
R6902	T10443	T10444	advmod	least,until
R6903	T10444	T10441	prep	until,persists
R6904	T10445	T10444	pobj	P8,until
R6905	T10446	T10441	prep	in,persists
R6906	T10447	T10448	det	the,apex
R6907	T10448	T10446	pobj	apex,in
R6908	T10449	T10448	prep	of,apex
R6909	T10450	T10451	npadvmod	Brn3c,null
R691	T1240	T1241	det	the,mutants
R6910	T10451	T10452	amod	null,mice
R6911	T10452	T10449	pobj	mice,of
R6912	T10453	T10441	prep	in,persists
R6913	T10454	T10455	det	an,area
R6914	T10455	T10453	pobj	area,in
R6915	T10456	T10457	dep	that,compares
R6916	T10457	T10455	relcl	compares,area
R6917	T10458	T10457	advmod	topologically,compares
R6918	T10459	T10457	prep	to,compares
R6919	T10460	T10461	det	the,cells
R692	T1241	T1239	pobj	mutants,in
R6920	T10461	T10459	pobj	cells,to
R6921	T10462	T10461	amod	inner,cells
R6922	T10463	T10461	compound	hair,cells
R6923	T10464	T10461	prep	of,cells
R6924	T10465	T10466	compound	control,animals
R6925	T10466	T10464	pobj	animals,of
R6926	T10467	T10468	punct	(,arrows
R6927	T10468	T10441	parataxis	arrows,persists
R6928	T10469	T10470	nmod	e,f
R6929	T10470	T10468	dep	f,arrows
R693	T1242	T1241	compound	Brn3c,mutants
R6930	T10471	T10470	punct	",",f
R6931	T10472	T10468	punct	", ",arrows
R6932	T10473	T10468	punct	),arrows
R6933	T10474	T10441	punct	.,persists
R6934	T10476	T10477	nsubj	Bar,indicates
R6935	T10478	T10479	nummod	100,μm
R6936	T10479	T10477	dobj	μm,indicates
R6937	T10480	T10477	punct	.,indicates
R6938	T10497	T10496	prep	of,Numbers
R6939	T10498	T10499	compound	hair,cells
R694	T1243	T1236	punct	", ",pattern
R6940	T10499	T10497	pobj	cells,of
R6941	T10500	T10499	cc	and,cells
R6942	T10501	T10502	amod	sensory,neurons
R6943	T10502	T10499	conj	neurons,cells
R6944	T10503	T10496	prep	in,Numbers
R6945	T10504	T10505	nmod	P7,wildtype
R6946	T10505	T10506	nmod	wildtype,littermates
R6947	T10506	T10503	pobj	littermates,in
R6948	T10507	T10505	cc	and,wildtype
R6949	T10508	T10509	npadvmod	Brn3c,mutant
R695	T1244	T1245	advmod	as,as
R6950	T10509	T10505	conj	mutant,wildtype
R696	T1245	T1236	cc	as,pattern
R697	T1246	T1245	advmod	well,as
R698	T1247	T1248	det	the,expression
R699	T1248	T1236	conj	expression,pattern
R7	T194	T196	nmod	term,retention
R70	T266	T263	conj	of,of
R700	T1249	T1248	prep	of,expression
R701	T1250	T1249	pobj	NT,of
R702	T1251	T1250	punct	-,NT
R703	T1252	T1250	nummod	3,NT
R704	T1253	T1250	cc	and,NT
R705	T1254	T1250	conj	BDNF,NT
R706	T1255	T1231	punct	.,investigated
R707	T1257	T1258	nsubj	We,want
R708	T1259	T1260	aux	to,evaluate
R709	T1260	T1258	xcomp	evaluate,want
R71	T267	T266	pobj	expression,of
R710	T1261	T1262	det	a,correlation
R711	T1262	T1260	dobj	correlation,evaluate
R712	T1263	T1262	amod	possible,correlation
R713	T1264	T1262	prep	between,correlation
R714	T1265	T1266	det	the,topology
R715	T1266	T1264	pobj	topology,between
R716	T1267	T1266	prep	of,topology
R717	T1268	T1269	amod	sensory,neuron
R718	T1269	T1270	compound	neuron,loss
R719	T1270	T1267	pobj	loss,of
R72	T268	T266	prep	of,of
R720	T1271	T1266	cc	and,topology
R721	T1272	T1266	conj	absence,topology
R722	T1273	T1272	prep	of,absence
R723	T1274	T1275	det	a,neurotrophin
R724	T1275	T1273	pobj	neurotrophin,of
R725	T1276	T1275	amod	specific,neurotrophin
R726	T1277	T1275	cc	or,neurotrophin
R727	T1278	T1279	amod	topological,loss
R728	T1279	T1275	conj	loss,neurotrophin
R729	T1280	T1279	prep	of,loss
R73	T269	T270	amod	known,neurotrophins
R730	T1281	T1282	compound	hair,cells
R731	T1282	T1280	pobj	cells,of
R732	T1283	T1262	prep	at,correlation
R733	T1284	T1283	pobj	birth,at
R734	T1285	T1283	cc	and,at
R735	T1286	T1283	conj	in,at
R736	T1287	T1288	amod	older,animals
R737	T1288	T1286	pobj	animals,in
R738	T1289	T1258	punct	.,want
R739	T1291	T1292	det	This,information
R74	T270	T268	pobj	neurotrophins,of
R740	T1292	T1293	nsubj	information,be
R741	T1294	T1293	aux	could,be
R742	T1295	T1293	acomp	important,be
R743	T1296	T1295	prep	for,important
R744	T1297	T1298	det	an,evaluation
R745	T1298	T1296	pobj	evaluation,for
R746	T1299	T1298	nmod	in,evaluation
R747	T1300	T1299	punct	-,in
R748	T1301	T1299	pobj	depth,in
R749	T1302	T1298	prep	of,evaluation
R75	T271	T255	punct	.,investigated
R750	T1303	T1304	det	the,deafness
R751	T1304	T1302	pobj	deafness,of
R752	T1305	T1304	amod	human,deafness
R753	T1306	T1304	acl	related,deafness
R754	T1307	T1306	prep	to,related
R755	T1308	T1309	det	the,gene
R756	T1309	T1307	pobj	gene,to
R757	T1310	T1309	compound	Pou4f3,gene
R758	T1311	T1309	punct	", ",gene
R759	T1312	T1309	appos	DFNA15,gene
R76	T275	T276	prep	At,is
R760	T1313	T1314	punct	[,12
R761	T1314	T1293	parataxis	12,be
R762	T1315	T1314	punct	],12
R763	T1316	T1293	punct	.,be
R764	T1318	T1319	nsubj	We,report
R765	T1320	T1319	advmod	here,report
R766	T1321	T1322	amod	long,term
R767	T1322	T1323	compound	term,retention
R768	T1323	T1319	dobj	retention,report
R769	T1324	T1323	prep	of,retention
R77	T277	T275	pobj	birth,At
R770	T1325	T1326	amod	cochlear,neurons
R771	T1326	T1324	pobj	neurons,of
R772	T1327	T1326	amod	sensory,neurons
R773	T1328	T1323	prep	for,retention
R774	T1329	T1330	advmod	at,6
R775	T1330	T1332	nummod	6,months
R776	T1331	T1330	advmod	least,6
R777	T1332	T1328	pobj	months,for
R778	T1333	T1323	punct	", ",retention
R779	T1334	T1335	prep	in,in
R78	T278	T276	expl	there,is
R780	T1335	T1323	prep	in,retention
R781	T1336	T1334	amod	particular,in
R782	T1337	T1338	det	the,apex
R783	T1338	T1335	pobj	apex,in
R784	T1339	T1338	amod	cochlear,apex
R785	T1340	T1323	punct	", ",retention
R786	T1341	T1323	prep	in,retention
R787	T1342	T1343	npadvmod	Brn3c,null
R788	T1343	T1344	amod	null,mice
R789	T1344	T1341	pobj	mice,in
R79	T279	T280	det	a,expression
R790	T1345	T1344	amod	mutant,mice
R791	T1346	T1319	punct	.,report
R792	T1348	T1349	det	This,retention
R793	T1349	T1350	nsubj	retention,is
R794	T1351	T1349	prep	of,retention
R795	T1352	T1351	pobj	afferents,of
R796	T1353	T1352	cc	and,afferents
R797	T1354	T1352	conj	efferents,afferents
R798	T1355	T1350	acomp	unrelated,is
R799	T1356	T1355	prep	to,unrelated
R8	T195	T194	punct	-,term
R80	T280	T276	attr	expression,is
R800	T1357	T1358	compound	hair,cell
R801	T1358	T1359	compound	cell,differentiation
R802	T1359	T1356	pobj	differentiation,to
R803	T1360	T1361	mark	as,detected
R804	T1361	T1350	advcl	detected,is
R805	T1362	T1363	neg	not,cells
R806	T1363	T1361	nsubjpass	cells,detected
R807	T1364	T1363	advmod	even,cells
R808	T1365	T1363	amod	immature,cells
R809	T1366	T1363	compound	hair,cells
R81	T281	T280	amod	limited,expression
R810	T1367	T1361	aux	can,detected
R811	T1368	T1361	auxpass	be,detected
R812	T1369	T1361	prep	at,detected
R813	T1370	T1371	amod	early,stages
R814	T1371	T1369	pobj	stages,at
R815	T1372	T1371	amod	postnatal,stages
R816	T1373	T1361	prep	with,detected
R817	T1374	T1375	compound	MyoVII,immunocytochemistry
R818	T1375	T1373	pobj	immunocytochemistry,with
R819	T1376	T1361	prep	in,detected
R82	T282	T280	prep	of,expression
R820	T1377	T1378	det	this,part
R821	T1378	T1376	pobj	part,in
R822	T1379	T1378	prep	of,part
R823	T1380	T1381	det	the,cochlea
R824	T1381	T1379	pobj	cochlea,of
R825	T1382	T1350	punct	.,is
R826	T1384	T1385	det	This,retention
R827	T1385	T1386	nsubj	retention,is
R828	T1387	T1385	prep	of,retention
R829	T1388	T1389	amod	apical,neurons
R83	T283	T282	pobj	BDNF,of
R830	T1389	T1387	pobj	neurons,of
R831	T1390	T1389	amod	spiral,neurons
R832	T1391	T1386	advmod	also,is
R833	T1392	T1393	advmod	largely,unrelated
R834	T1393	T1386	acomp	unrelated,is
R835	T1394	T1393	prep	to,unrelated
R836	T1395	T1394	pobj	neurotrophins,to
R837	T1396	T1397	dep	which,known
R838	T1397	T1395	relcl	known,neurotrophins
R839	T1398	T1397	auxpass	are,known
R84	T284	T283	cc	and,BDNF
R840	T1399	T1400	aux	to,reduced
R841	T1400	T1397	xcomp	reduced,known
R842	T1401	T1400	auxpass	be,reduced
R843	T1402	T1400	prep	in,reduced
R844	T1403	T1404	poss	their,expression
R845	T1404	T1402	pobj	expression,in
R846	T1405	T1397	prep	in,known
R847	T1406	T1407	amod	neonatal,rodents
R848	T1407	T1405	pobj	rodents,in
R849	T1408	T1409	punct	[,4
R85	T285	T283	conj	NT,BDNF
R850	T1409	T1386	parataxis	4,is
R851	T1410	T1409	punct	],4
R852	T1411	T1386	punct	.,is
R854	T1476	T1477	aux	To,appreciate
R855	T1477	T1478	advcl	appreciate,want
R856	T1479	T1480	det	the,effects
R857	T1480	T1477	dobj	effects,appreciate
R858	T1481	T1480	prep	of,effects
R859	T1482	T1483	det	the,mutation
R86	T286	T285	punct	-,NT
R860	T1483	T1481	pobj	mutation,of
R861	T1484	T1483	nmod	Brn3c,mutation
R862	T1485	T1483	amod	null,mutation
R863	T1486	T1480	prep	on,effects
R864	T1487	T1488	det	the,pattern
R865	T1488	T1486	pobj	pattern,on
R866	T1489	T1488	prep	of,pattern
R867	T1490	T1491	det	the,innervation
R868	T1491	T1489	pobj	innervation,of
R869	T1492	T1493	amod	inner,ear
R87	T287	T285	nummod	3,NT
R870	T1493	T1491	compound	ear,innervation
R871	T1494	T1478	punct	", ",want
R872	T1495	T1478	nsubj	we,want
R873	T1496	T1478	advmod	first,want
R874	T1497	T1498	aux	to,present
R875	T1498	T1478	xcomp	present,want
R876	T1499	T1500	det	the,effects
R877	T1500	T1498	dobj	effects,present
R878	T1501	T1500	prep	of,effects
R879	T1502	T1503	nmod	BDNF,mutations
R88	T288	T276	prep	in,is
R880	T1503	T1501	pobj	mutations,of
R881	T1504	T1502	cc	and,BDNF
R882	T1505	T1502	conj	NT,BDNF
R883	T1506	T1505	punct	-,NT
R884	T1507	T1505	nummod	3,NT
R885	T1508	T1503	amod	null,mutations
R886	T1509	T1503	prep	at,mutations
R887	T1510	T1509	pobj	birth,at
R888	T1511	T1512	punct	[,14
R889	T1512	T1478	parataxis	14,want
R89	T289	T290	det	the,epithelia
R890	T1513	T1512	nummod	6,14
R891	T1514	T1512	punct	",",14
R892	T1515	T1512	nummod	13,14
R893	T1516	T1512	punct	",",14
R894	T1517	T1512	punct	],14
R895	T1518	T1478	punct	.,want
R896	T1520	T1521	amod	Null,mutants
R897	T1521	T1522	nsubj	mutants,lose
R898	T1523	T1521	prep	of,mutants
R899	T1524	T1523	pobj	BDNF,of
R9	T196	T192	dobj	retention,show
R90	T290	T288	pobj	epithelia,in
R900	T1525	T1524	cc	or,BDNF
R901	T1526	T1527	poss	its,receptor
R902	T1527	T1524	conj	receptor,BDNF
R903	T1528	T1527	appos	trkB,receptor
R904	T1529	T1530	det	all,innervation
R905	T1530	T1522	dobj	innervation,lose
R906	T1531	T1530	prep	to,innervation
R907	T1532	T1533	det	the,canals
R908	T1533	T1531	pobj	canals,to
R909	T1534	T1533	amod	semicircular,canals
R91	T291	T290	amod	mutant,epithelia
R910	T1535	T1522	cc	and,lose
R911	T1536	T1522	conj	have,lose
R912	T1537	T1538	det	a,innervation
R913	T1538	T1536	dobj	innervation,have
R914	T1539	T1538	amod	reduced,innervation
R915	T1540	T1538	prep	to,innervation
R916	T1541	T1542	det	the,utricle
R917	T1542	T1540	pobj	utricle,to
R918	T1543	T1542	punct	", ",utricle
R919	T1544	T1542	conj	saccule,utricle
R92	T292	T290	amod	sensory,epithelia
R920	T1545	T1544	cc	and,saccule
R921	T1546	T1547	amod	apical,turn
R922	T1547	T1544	conj	turn,saccule
R923	T1548	T1547	prep	of,turn
R924	T1549	T1550	det	the,cochlea
R925	T1550	T1548	pobj	cochlea,of
R926	T1551	T1522	punct	.,lose
R927	T1553	T1554	prep	In,result
R928	T1555	T1553	pobj	contrast,In
R929	T1556	T1554	punct	", ",result
R93	T293	T276	cc	and,is
R930	T1557	T1558	amod	null,mutations
R931	T1558	T1554	nsubj	mutations,result
R932	T1559	T1558	prep	of,mutations
R933	T1560	T1561	preconj	either,NT
R934	T1561	T1559	pobj	NT,of
R935	T1562	T1561	punct	-,NT
R936	T1563	T1561	nummod	3,NT
R937	T1564	T1561	cc	or,NT
R938	T1565	T1566	poss	its,receptor
R939	T1566	T1561	conj	receptor,NT
R94	T294	T295	compound	DiI,tracing
R940	T1567	T1566	appos	trkC,receptor
R941	T1568	T1554	prep	in,result
R942	T1569	T1568	pobj	loss,in
R943	T1570	T1569	prep	of,loss
R944	T1571	T1572	amod	spiral,neurons
R945	T1572	T1570	pobj	neurons,of
R946	T1573	T1569	prep	in,loss
R947	T1574	T1575	det	the,turn
R948	T1575	T1573	pobj	turn,in
R949	T1576	T1575	amod	basal,turn
R95	T295	T296	nsubj	tracing,shows
R950	T1577	T1569	prep	with,loss
R951	T1578	T1577	pobj	formation,with
R952	T1579	T1578	prep	of,formation
R953	T1580	T1581	det	an,bundle
R954	T1581	T1579	pobj	bundle,of
R955	T1582	T1583	amod	inner,spiral
R956	T1583	T1581	nmod	spiral,bundle
R957	T1584	T1581	prep	of,bundle
R958	T1585	T1584	pobj	afferents,of
R959	T1586	T1581	acl	extending,bundle
R96	T296	T276	conj	shows,is
R960	T1587	T1586	prep	to,extending
R961	T1588	T1589	det	the,tip
R962	T1589	T1587	pobj	tip,to
R963	T1590	T1589	amod	basal,tip
R964	T1591	T1554	punct	.,result
R965	T1593	T1594	poss	Our,hypothesis
R966	T1594	T1596	nsubj	hypothesis,be
R967	T1595	T1594	amod	null,hypothesis
R968	T1597	T1594	prep	for,hypothesis
R969	T1598	T1599	det	this,study
R97	T297	T298	det	no,reduction
R970	T1599	T1597	pobj	study,for
R971	T1600	T1596	aux	would,be
R972	T1601	T1602	mark	that,show
R973	T1602	T1596	ccomp	show,be
R974	T1603	T1604	nmod	Brn3c,mice
R975	T1604	T1602	nsubj	mice,show
R976	T1605	T1604	amod	null,mice
R977	T1606	T1607	amod	severe,production
R978	T1607	T1602	dobj	production,show
R979	T1608	T1607	amod	compromised,production
R98	T298	T296	dobj	reduction,shows
R980	T1609	T1607	prep	of,production
R981	T1610	T1611	det	these,neurotrophins
R982	T1611	T1609	pobj	neurotrophins,of
R983	T1612	T1602	cc	and,show
R984	T1613	T1614	aux	should,show
R985	T1614	T1602	conj	show,show
R986	T1615	T1614	advmod	therefore,show
R987	T1616	T1617	det	a,pattern
R988	T1617	T1614	dobj	pattern,show
R989	T1618	T1617	amod	comparable,pattern
R99	T299	T298	amod	specific,reduction
R990	T1619	T1617	prep	of,pattern
R991	T1620	T1621	compound	nerve,fiber
R992	T1621	T1622	compound	fiber,loss
R993	T1622	T1619	pobj	loss,of
R994	T1623	T1596	punct	.,be
R999	T1846	T1847	npadvmod	Brn3c,null

PMC:149366 JSONTXT 7 Projects

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PMC:149366 JSON TXT 7 Projects