Id |
Subject |
Object |
Predicate |
Lexical cue |
T1246 |
0-1 |
DT |
denotes |
A |
T1248 |
2-6 |
RB |
denotes |
much |
T1249 |
7-14 |
JJR |
denotes |
broader |
T1247 |
15-20 |
NN |
denotes |
scope |
T1251 |
21-23 |
IN |
denotes |
of |
T1252 |
24-32 |
JJ |
denotes |
cellular |
T1253 |
33-42 |
NNS |
denotes |
functions |
T1254 |
43-45 |
IN |
denotes |
of |
T1255 |
46-51 |
NN |
denotes |
alpha |
T1257 |
51-52 |
HYPH |
denotes |
- |
T1256 |
52-62 |
NN |
denotes |
crystallin |
T1258 |
63-65 |
IN |
denotes |
in |
T1259 |
66-70 |
NN |
denotes |
lens |
T1260 |
71-73 |
VBZ |
denotes |
is |
T1250 |
74-82 |
VBN |
denotes |
inferred |
T1261 |
83-87 |
IN |
denotes |
from |
T1262 |
88-90 |
FW |
denotes |
in |
T1263 |
91-96 |
FW |
denotes |
vitro |
T1264 |
97-109 |
NNS |
denotes |
observations |
T1265 |
109-110 |
. |
denotes |
. |
T1266 |
110-197 |
sentence |
denotes |
Both alphaA and alphaB can bind specifically to actin, in vitro [13] and in vivo [14]. |
T1267 |
111-115 |
CC |
denotes |
Both |
T1268 |
116-122 |
NN |
denotes |
alphaA |
T1270 |
123-126 |
CC |
denotes |
and |
T1271 |
127-133 |
NN |
denotes |
alphaB |
T1272 |
134-137 |
MD |
denotes |
can |
T1269 |
138-142 |
VB |
denotes |
bind |
T1273 |
143-155 |
RB |
denotes |
specifically |
T1274 |
156-158 |
IN |
denotes |
to |
T1275 |
159-164 |
NN |
denotes |
actin |
T1276 |
164-166 |
, |
denotes |
, |
T1277 |
166-168 |
FW |
denotes |
in |
T1279 |
169-174 |
FW |
denotes |
vitro |
T1280 |
175-176 |
-LRB- |
denotes |
[ |
T1278 |
176-178 |
CD |
denotes |
13 |
T1281 |
178-179 |
-RRB- |
denotes |
] |
T1282 |
180-183 |
CC |
denotes |
and |
T1283 |
184-186 |
FW |
denotes |
in |
T1285 |
187-191 |
FW |
denotes |
vivo |
T1286 |
192-193 |
-LRB- |
denotes |
[ |
T1284 |
193-195 |
CD |
denotes |
14 |
T1287 |
195-196 |
-RRB- |
denotes |
] |
T1288 |
196-197 |
. |
denotes |
. |
T1289 |
197-408 |
sentence |
denotes |
Although actin filament formation has been shown to be necessary for differentiation of lens epithelial cells [15], the significance of alpha-crystallin's interaction with actin in differentiation is not known. |
T1290 |
198-206 |
IN |
denotes |
Although |
T1292 |
207-212 |
NN |
denotes |
actin |
T1293 |
213-221 |
NN |
denotes |
filament |
T1294 |
222-231 |
NN |
denotes |
formation |
T1295 |
232-235 |
VBZ |
denotes |
has |
T1296 |
236-240 |
VBN |
denotes |
been |
T1291 |
241-246 |
VBN |
denotes |
shown |
T1298 |
247-249 |
TO |
denotes |
to |
T1299 |
250-252 |
VB |
denotes |
be |
T1300 |
253-262 |
JJ |
denotes |
necessary |
T1301 |
263-266 |
IN |
denotes |
for |
T1302 |
267-282 |
NN |
denotes |
differentiation |
T1303 |
283-285 |
IN |
denotes |
of |
T1304 |
286-290 |
NN |
denotes |
lens |
T1306 |
291-301 |
JJ |
denotes |
epithelial |
T1305 |
302-307 |
NNS |
denotes |
cells |
T1307 |
308-309 |
-LRB- |
denotes |
[ |
T1308 |
309-311 |
CD |
denotes |
15 |
T1309 |
311-312 |
-RRB- |
denotes |
] |
T1310 |
312-314 |
, |
denotes |
, |
T1311 |
314-317 |
DT |
denotes |
the |
T1312 |
318-330 |
NN |
denotes |
significance |
T1313 |
331-333 |
IN |
denotes |
of |
T1314 |
334-339 |
NN |
denotes |
alpha |
T1316 |
339-340 |
HYPH |
denotes |
- |
T1315 |
340-350 |
NN |
denotes |
crystallin |
T1318 |
350-352 |
POS |
denotes |
's |
T1317 |
353-364 |
NN |
denotes |
interaction |
T1319 |
365-369 |
IN |
denotes |
with |
T1320 |
370-375 |
NN |
denotes |
actin |
T1321 |
376-378 |
IN |
denotes |
in |
T1322 |
379-394 |
NN |
denotes |
differentiation |
T1323 |
395-397 |
VBZ |
denotes |
is |
T1324 |
398-401 |
RB |
denotes |
not |
T1297 |
402-407 |
VBN |
denotes |
known |
T1325 |
407-408 |
. |
denotes |
. |
T1326 |
408-649 |
sentence |
denotes |
In the lens, alpha-crystallin also associates with type III intermediate filament proteins and the beaded filament proteins CP49 and CP115, and correct beaded filament assembly has been shown depend on the presence of alpha-crystallin [16]. |
T1327 |
409-411 |
IN |
denotes |
In |
T1329 |
412-415 |
DT |
denotes |
the |
T1330 |
416-420 |
NN |
denotes |
lens |
T1331 |
420-422 |
, |
denotes |
, |
T1332 |
422-427 |
NN |
denotes |
alpha |
T1334 |
427-428 |
HYPH |
denotes |
- |
T1333 |
428-438 |
NN |
denotes |
crystallin |
T1335 |
439-443 |
RB |
denotes |
also |
T1328 |
444-454 |
VBZ |
denotes |
associates |
T1336 |
455-459 |
IN |
denotes |
with |
T1337 |
460-464 |
NN |
denotes |
type |
T1339 |
465-468 |
CD |
denotes |
III |
T1340 |
469-481 |
JJ |
denotes |
intermediate |
T1341 |
482-490 |
NN |
denotes |
filament |
T1338 |
491-499 |
NN |
denotes |
proteins |
T1342 |
500-503 |
CC |
denotes |
and |
T1343 |
504-507 |
DT |
denotes |
the |
T1345 |
508-514 |
VBN |
denotes |
beaded |
T1346 |
515-523 |
NN |
denotes |
filament |
T1344 |
524-532 |
NN |
denotes |
proteins |
T1347 |
533-537 |
NN |
denotes |
CP49 |
T1348 |
538-541 |
CC |
denotes |
and |
T1349 |
542-547 |
NN |
denotes |
CP115 |
T1350 |
547-549 |
, |
denotes |
, |
T1351 |
549-552 |
CC |
denotes |
and |
T1352 |
553-560 |
JJ |
denotes |
correct |
T1354 |
561-567 |
VBN |
denotes |
beaded |
T1355 |
568-576 |
NN |
denotes |
filament |
T1353 |
577-585 |
NN |
denotes |
assembly |
T1357 |
586-589 |
VBZ |
denotes |
has |
T1358 |
590-594 |
VBN |
denotes |
been |
T1356 |
595-600 |
VBN |
denotes |
shown |
T1359 |
601-607 |
VB |
denotes |
depend |
T1360 |
608-610 |
IN |
denotes |
on |
T1361 |
611-614 |
DT |
denotes |
the |
T1362 |
615-623 |
NN |
denotes |
presence |
T1363 |
624-626 |
IN |
denotes |
of |
T1364 |
627-632 |
NN |
denotes |
alpha |
T1366 |
632-633 |
HYPH |
denotes |
- |
T1365 |
633-643 |
NN |
denotes |
crystallin |
T1367 |
644-645 |
-LRB- |
denotes |
[ |
T1368 |
645-647 |
CD |
denotes |
16 |
T1369 |
647-648 |
-RRB- |
denotes |
] |
T1370 |
648-649 |
. |
denotes |
. |
T1371 |
649-816 |
sentence |
denotes |
Beaded filament mRNA levels are greatly increased in differentiating lens epithelium and have been suggested as a pan-specific marker for lens fiber development [17]. |
T1372 |
650-656 |
VBN |
denotes |
Beaded |
T1373 |
657-665 |
NN |
denotes |
filament |
T1375 |
666-670 |
NN |
denotes |
mRNA |
T1374 |
671-677 |
NNS |
denotes |
levels |
T1377 |
678-681 |
VBP |
denotes |
are |
T1378 |
682-689 |
RB |
denotes |
greatly |
T1376 |
690-699 |
VBN |
denotes |
increased |
T1379 |
700-702 |
IN |
denotes |
in |
T1380 |
703-718 |
VBG |
denotes |
differentiating |
T1382 |
719-723 |
NN |
denotes |
lens |
T1381 |
724-734 |
NN |
denotes |
epithelium |
T1383 |
735-738 |
CC |
denotes |
and |
T1384 |
739-743 |
VBP |
denotes |
have |
T1386 |
744-748 |
VBN |
denotes |
been |
T1385 |
749-758 |
VBN |
denotes |
suggested |
T1387 |
759-761 |
IN |
denotes |
as |
T1388 |
762-763 |
DT |
denotes |
a |
T1390 |
764-776 |
JJ |
denotes |
pan-specific |
T1389 |
777-783 |
NN |
denotes |
marker |
T1391 |
784-787 |
IN |
denotes |
for |
T1392 |
788-792 |
NN |
denotes |
lens |
T1393 |
793-798 |
NN |
denotes |
fiber |
T1394 |
799-810 |
NN |
denotes |
development |
T1395 |
811-812 |
-LRB- |
denotes |
[ |
T1396 |
812-814 |
CD |
denotes |
17 |
T1397 |
814-815 |
-RRB- |
denotes |
] |
T1398 |
815-816 |
. |
denotes |
. |
T1399 |
816-889 |
sentence |
denotes |
Alpha-crystallin has also been shown to interact directly with DNA [18]. |
T1400 |
817-822 |
NNP |
denotes |
Alpha |
T1402 |
822-823 |
HYPH |
denotes |
- |
T1401 |
823-833 |
NNP |
denotes |
crystallin |
T1404 |
834-837 |
VBZ |
denotes |
has |
T1405 |
838-842 |
RB |
denotes |
also |
T1406 |
843-847 |
VBN |
denotes |
been |
T1403 |
848-853 |
VBN |
denotes |
shown |
T1407 |
854-856 |
TO |
denotes |
to |
T1408 |
857-865 |
VB |
denotes |
interact |
T1409 |
866-874 |
RB |
denotes |
directly |
T1410 |
875-879 |
IN |
denotes |
with |
T1411 |
880-883 |
NN |
denotes |
DNA |
T1412 |
884-885 |
-LRB- |
denotes |
[ |
T1413 |
885-887 |
CD |
denotes |
18 |
T1414 |
887-888 |
-RRB- |
denotes |
] |
T1415 |
888-889 |
. |
denotes |
. |
T1416 |
889-1044 |
sentence |
denotes |
In transfected CHO cells, alphaB has also been shown to ectopically localize to interphase nuclei, suggesting a role for this protein in the nucleus [19]. |
T1417 |
890-892 |
IN |
denotes |
In |
T1419 |
893-904 |
JJ |
denotes |
transfected |
T1421 |
905-908 |
NN |
denotes |
CHO |
T1420 |
909-914 |
NNS |
denotes |
cells |
T1422 |
914-916 |
, |
denotes |
, |
T1423 |
916-922 |
NN |
denotes |
alphaB |
T1424 |
923-926 |
VBZ |
denotes |
has |
T1425 |
927-931 |
RB |
denotes |
also |
T1426 |
932-936 |
VBN |
denotes |
been |
T1418 |
937-942 |
VBN |
denotes |
shown |
T1427 |
943-945 |
TO |
denotes |
to |
T1429 |
946-957 |
RB |
denotes |
ectopically |
T1428 |
958-966 |
VB |
denotes |
localize |
T1430 |
967-969 |
IN |
denotes |
to |
T1431 |
970-980 |
NN |
denotes |
interphase |
T1432 |
981-987 |
NNS |
denotes |
nuclei |
T1433 |
987-989 |
, |
denotes |
, |
T1434 |
989-999 |
VBG |
denotes |
suggesting |
T1435 |
1000-1001 |
DT |
denotes |
a |
T1436 |
1002-1006 |
NN |
denotes |
role |
T1437 |
1007-1010 |
IN |
denotes |
for |
T1438 |
1011-1015 |
DT |
denotes |
this |
T1439 |
1016-1023 |
NN |
denotes |
protein |
T1440 |
1024-1026 |
IN |
denotes |
in |
T1441 |
1027-1030 |
DT |
denotes |
the |
T1442 |
1031-1038 |
NN |
denotes |
nucleus |
T1443 |
1039-1040 |
-LRB- |
denotes |
[ |
T1444 |
1040-1042 |
CD |
denotes |
19 |
T1445 |
1042-1043 |
-RRB- |
denotes |
] |
T1446 |
1043-1044 |
. |
denotes |
. |
T1447 |
1044-1247 |
sentence |
denotes |
A nuclear role for alphaB in the lens was supported by the findings that a subset of lens epithelial cells derived from alphaB knockout mice demonstrated hyperproliferation and genomic instability [20]. |
T1448 |
1045-1046 |
DT |
denotes |
A |
T1450 |
1047-1054 |
JJ |
denotes |
nuclear |
T1449 |
1055-1059 |
NN |
denotes |
role |
T1452 |
1060-1063 |
IN |
denotes |
for |
T1453 |
1064-1070 |
NN |
denotes |
alphaB |
T1454 |
1071-1073 |
IN |
denotes |
in |
T1455 |
1074-1077 |
DT |
denotes |
the |
T1456 |
1078-1082 |
NN |
denotes |
lens |
T1457 |
1083-1086 |
VBD |
denotes |
was |
T1451 |
1087-1096 |
VBN |
denotes |
supported |
T1458 |
1097-1099 |
IN |
denotes |
by |
T1459 |
1100-1103 |
DT |
denotes |
the |
T1460 |
1104-1112 |
NNS |
denotes |
findings |
T1461 |
1113-1117 |
IN |
denotes |
that |
T1463 |
1118-1119 |
DT |
denotes |
a |
T1464 |
1120-1126 |
NN |
denotes |
subset |
T1465 |
1127-1129 |
IN |
denotes |
of |
T1466 |
1130-1134 |
NN |
denotes |
lens |
T1468 |
1135-1145 |
JJ |
denotes |
epithelial |
T1467 |
1146-1151 |
NNS |
denotes |
cells |
T1469 |
1152-1159 |
VBN |
denotes |
derived |
T1470 |
1160-1164 |
IN |
denotes |
from |
T1471 |
1165-1171 |
NN |
denotes |
alphaB |
T1473 |
1172-1180 |
NN |
denotes |
knockout |
T1472 |
1181-1185 |
NNS |
denotes |
mice |
T1462 |
1186-1198 |
VBD |
denotes |
demonstrated |
T1474 |
1199-1217 |
NN |
denotes |
hyperproliferation |
T1475 |
1218-1221 |
CC |
denotes |
and |
T1476 |
1222-1229 |
JJ |
denotes |
genomic |
T1477 |
1230-1241 |
NN |
denotes |
instability |
T1478 |
1242-1243 |
-LRB- |
denotes |
[ |
T1479 |
1243-1245 |
CD |
denotes |
20 |
T1480 |
1245-1246 |
-RRB- |
denotes |
] |
T1481 |
1246-1247 |
. |
denotes |
. |
T1482 |
1247-1474 |
sentence |
denotes |
In addition, the administration of exogenous alpha-crystallin to primary bovine lens epithelial cell cultures resulted in the formation of lentoid bodies, consistent with a role for these proteins in lens differentiation [21]. |
T1483 |
1248-1250 |
IN |
denotes |
In |
T1485 |
1251-1259 |
NN |
denotes |
addition |
T1486 |
1259-1261 |
, |
denotes |
, |
T1487 |
1261-1264 |
DT |
denotes |
the |
T1488 |
1265-1279 |
NN |
denotes |
administration |
T1489 |
1280-1282 |
IN |
denotes |
of |
T1490 |
1283-1292 |
JJ |
denotes |
exogenous |
T1492 |
1293-1298 |
NN |
denotes |
alpha |
T1493 |
1298-1299 |
HYPH |
denotes |
- |
T1491 |
1299-1309 |
NN |
denotes |
crystallin |
T1494 |
1310-1312 |
IN |
denotes |
to |
T1495 |
1313-1320 |
JJ |
denotes |
primary |
T1497 |
1321-1327 |
JJ |
denotes |
bovine |
T1498 |
1328-1332 |
NN |
denotes |
lens |
T1500 |
1333-1343 |
JJ |
denotes |
epithelial |
T1499 |
1344-1348 |
NN |
denotes |
cell |
T1496 |
1349-1357 |
NNS |
denotes |
cultures |
T1484 |
1358-1366 |
VBD |
denotes |
resulted |
T1501 |
1367-1369 |
IN |
denotes |
in |
T1502 |
1370-1373 |
DT |
denotes |
the |
T1503 |
1374-1383 |
NN |
denotes |
formation |
T1504 |
1384-1386 |
IN |
denotes |
of |
T1505 |
1387-1394 |
JJ |
denotes |
lentoid |
T1506 |
1395-1401 |
NNS |
denotes |
bodies |
T1507 |
1401-1403 |
, |
denotes |
, |
T1508 |
1403-1413 |
JJ |
denotes |
consistent |
T1509 |
1414-1418 |
IN |
denotes |
with |
T1510 |
1419-1420 |
DT |
denotes |
a |
T1511 |
1421-1425 |
NN |
denotes |
role |
T1512 |
1426-1429 |
IN |
denotes |
for |
T1513 |
1430-1435 |
DT |
denotes |
these |
T1514 |
1436-1444 |
NN |
denotes |
proteins |
T1515 |
1445-1447 |
IN |
denotes |
in |
T1516 |
1448-1452 |
NN |
denotes |
lens |
T1517 |
1453-1468 |
NN |
denotes |
differentiation |
T1518 |
1469-1470 |
-LRB- |
denotes |
[ |
T1519 |
1470-1472 |
CD |
denotes |
21 |
T1520 |
1472-1473 |
-RRB- |
denotes |
] |
T1521 |
1473-1474 |
. |
denotes |
. |
T1522 |
1474-1563 |
sentence |
denotes |
These findings indicate that alpha-crystallin may have a multitude of in vivo functions. |
T1523 |
1475-1480 |
DT |
denotes |
These |
T1524 |
1481-1489 |
NNS |
denotes |
findings |
T1525 |
1490-1498 |
VBP |
denotes |
indicate |
T1526 |
1499-1503 |
IN |
denotes |
that |
T1528 |
1504-1509 |
NN |
denotes |
alpha |
T1530 |
1509-1510 |
HYPH |
denotes |
- |
T1529 |
1510-1520 |
NN |
denotes |
crystallin |
T1531 |
1521-1524 |
MD |
denotes |
may |
T1527 |
1525-1529 |
VB |
denotes |
have |
T1532 |
1530-1531 |
DT |
denotes |
a |
T1533 |
1532-1541 |
NN |
denotes |
multitude |
T1534 |
1542-1544 |
IN |
denotes |
of |
T1535 |
1545-1547 |
FW |
denotes |
in |
T1536 |
1548-1552 |
FW |
denotes |
vivo |
T1537 |
1553-1562 |
NNS |
denotes |
functions |
T1538 |
1562-1563 |
. |
denotes |
. |
R694 |
T1246 |
T1247 |
det |
A,scope |
R695 |
T1247 |
T1250 |
nsubjpass |
scope,inferred |
R696 |
T1248 |
T1249 |
advmod |
much,broader |
R697 |
T1249 |
T1247 |
amod |
broader,scope |
R698 |
T1251 |
T1247 |
prep |
of,scope |
R699 |
T1252 |
T1253 |
amod |
cellular,functions |
R700 |
T1253 |
T1251 |
pobj |
functions,of |
R701 |
T1254 |
T1253 |
prep |
of,functions |
R702 |
T1255 |
T1256 |
compound |
alpha,crystallin |
R703 |
T1256 |
T1254 |
pobj |
crystallin,of |
R704 |
T1257 |
T1256 |
punct |
-,crystallin |
R705 |
T1258 |
T1253 |
prep |
in,functions |
R706 |
T1259 |
T1258 |
pobj |
lens,in |
R707 |
T1260 |
T1250 |
auxpass |
is,inferred |
R708 |
T1261 |
T1250 |
prep |
from,inferred |
R709 |
T1262 |
T1263 |
advmod |
in,vitro |
R710 |
T1263 |
T1264 |
amod |
vitro,observations |
R711 |
T1264 |
T1261 |
pobj |
observations,from |
R712 |
T1265 |
T1250 |
punct |
.,inferred |
R713 |
T1267 |
T1268 |
preconj |
Both,alphaA |
R714 |
T1268 |
T1269 |
nsubj |
alphaA,bind |
R715 |
T1270 |
T1268 |
cc |
and,alphaA |
R716 |
T1271 |
T1268 |
conj |
alphaB,alphaA |
R717 |
T1272 |
T1269 |
aux |
can,bind |
R718 |
T1273 |
T1269 |
advmod |
specifically,bind |
R719 |
T1274 |
T1269 |
prep |
to,bind |
R720 |
T1275 |
T1274 |
pobj |
actin,to |
R721 |
T1276 |
T1269 |
punct |
", ",bind |
R722 |
T1277 |
T1278 |
advmod |
in,13 |
R723 |
T1278 |
T1269 |
advmod |
13,bind |
R724 |
T1279 |
T1278 |
advmod |
vitro,13 |
R725 |
T1280 |
T1278 |
punct |
[,13 |
R726 |
T1281 |
T1278 |
punct |
],13 |
R727 |
T1282 |
T1278 |
cc |
and,13 |
R728 |
T1283 |
T1284 |
advmod |
in,14 |
R729 |
T1284 |
T1278 |
conj |
14,13 |
R730 |
T1285 |
T1284 |
advmod |
vivo,14 |
R731 |
T1286 |
T1284 |
punct |
[,14 |
R732 |
T1287 |
T1284 |
punct |
],14 |
R733 |
T1288 |
T1269 |
punct |
.,bind |
R734 |
T1290 |
T1291 |
mark |
Although,shown |
R735 |
T1291 |
T1297 |
advcl |
shown,known |
R736 |
T1292 |
T1293 |
compound |
actin,filament |
R737 |
T1293 |
T1294 |
compound |
filament,formation |
R738 |
T1294 |
T1291 |
nsubjpass |
formation,shown |
R739 |
T1295 |
T1291 |
aux |
has,shown |
R740 |
T1296 |
T1291 |
auxpass |
been,shown |
R741 |
T1298 |
T1299 |
aux |
to,be |
R742 |
T1299 |
T1291 |
xcomp |
be,shown |
R743 |
T1300 |
T1299 |
acomp |
necessary,be |
R744 |
T1301 |
T1300 |
prep |
for,necessary |
R745 |
T1302 |
T1301 |
pobj |
differentiation,for |
R746 |
T1303 |
T1302 |
prep |
of,differentiation |
R747 |
T1304 |
T1305 |
nmod |
lens,cells |
R748 |
T1305 |
T1303 |
pobj |
cells,of |
R749 |
T1306 |
T1305 |
amod |
epithelial,cells |
R750 |
T1307 |
T1308 |
punct |
[,15 |
R751 |
T1308 |
T1291 |
parataxis |
15,shown |
R752 |
T1309 |
T1308 |
punct |
],15 |
R753 |
T1310 |
T1297 |
punct |
", ",known |
R754 |
T1311 |
T1312 |
det |
the,significance |
R755 |
T1312 |
T1297 |
nsubjpass |
significance,known |
R756 |
T1313 |
T1312 |
prep |
of,significance |
R757 |
T1314 |
T1315 |
compound |
alpha,crystallin |
R758 |
T1315 |
T1317 |
poss |
crystallin,interaction |
R759 |
T1316 |
T1315 |
punct |
-,crystallin |
R760 |
T1317 |
T1313 |
pobj |
interaction,of |
R761 |
T1318 |
T1315 |
case |
's,crystallin |
R762 |
T1319 |
T1317 |
prep |
with,interaction |
R763 |
T1320 |
T1319 |
pobj |
actin,with |
R764 |
T1321 |
T1317 |
prep |
in,interaction |
R765 |
T1322 |
T1321 |
pobj |
differentiation,in |
R766 |
T1323 |
T1297 |
auxpass |
is,known |
R767 |
T1324 |
T1297 |
neg |
not,known |
R768 |
T1325 |
T1297 |
punct |
.,known |
R769 |
T1327 |
T1328 |
prep |
In,associates |
R770 |
T1329 |
T1330 |
det |
the,lens |
R771 |
T1330 |
T1327 |
pobj |
lens,In |
R772 |
T1331 |
T1328 |
punct |
", ",associates |
R773 |
T1332 |
T1333 |
compound |
alpha,crystallin |
R774 |
T1333 |
T1328 |
nsubj |
crystallin,associates |
R775 |
T1334 |
T1333 |
punct |
-,crystallin |
R776 |
T1335 |
T1328 |
advmod |
also,associates |
R777 |
T1336 |
T1328 |
prep |
with,associates |
R778 |
T1337 |
T1338 |
nmod |
type,proteins |
R779 |
T1338 |
T1336 |
pobj |
proteins,with |
R780 |
T1339 |
T1337 |
nummod |
III,type |
R781 |
T1340 |
T1341 |
amod |
intermediate,filament |
R782 |
T1341 |
T1338 |
compound |
filament,proteins |
R783 |
T1342 |
T1338 |
cc |
and,proteins |
R784 |
T1343 |
T1344 |
det |
the,proteins |
R785 |
T1344 |
T1338 |
conj |
proteins,proteins |
R786 |
T1345 |
T1346 |
amod |
beaded,filament |
R787 |
T1346 |
T1344 |
compound |
filament,proteins |
R788 |
T1347 |
T1344 |
appos |
CP49,proteins |
R789 |
T1348 |
T1347 |
cc |
and,CP49 |
R790 |
T1349 |
T1347 |
conj |
CP115,CP49 |
R791 |
T1350 |
T1328 |
punct |
", ",associates |
R792 |
T1351 |
T1328 |
cc |
and,associates |
R793 |
T1352 |
T1353 |
amod |
correct,assembly |
R794 |
T1353 |
T1356 |
nsubjpass |
assembly,shown |
R795 |
T1354 |
T1355 |
amod |
beaded,filament |
R796 |
T1355 |
T1353 |
compound |
filament,assembly |
R797 |
T1356 |
T1328 |
conj |
shown,associates |
R798 |
T1357 |
T1356 |
aux |
has,shown |
R799 |
T1358 |
T1356 |
auxpass |
been,shown |
R800 |
T1359 |
T1356 |
xcomp |
depend,shown |
R801 |
T1360 |
T1359 |
prep |
on,depend |
R802 |
T1361 |
T1362 |
det |
the,presence |
R803 |
T1362 |
T1360 |
pobj |
presence,on |
R804 |
T1363 |
T1362 |
prep |
of,presence |
R805 |
T1364 |
T1365 |
compound |
alpha,crystallin |
R806 |
T1365 |
T1363 |
pobj |
crystallin,of |
R807 |
T1366 |
T1365 |
punct |
-,crystallin |
R808 |
T1367 |
T1368 |
punct |
[,16 |
R809 |
T1368 |
T1356 |
parataxis |
16,shown |
R810 |
T1369 |
T1368 |
punct |
],16 |
R811 |
T1370 |
T1328 |
punct |
.,associates |
R812 |
T1372 |
T1373 |
amod |
Beaded,filament |
R813 |
T1373 |
T1374 |
compound |
filament,levels |
R814 |
T1374 |
T1376 |
nsubjpass |
levels,increased |
R815 |
T1375 |
T1374 |
compound |
mRNA,levels |
R816 |
T1377 |
T1376 |
auxpass |
are,increased |
R817 |
T1378 |
T1376 |
advmod |
greatly,increased |
R818 |
T1379 |
T1376 |
prep |
in,increased |
R819 |
T1380 |
T1381 |
amod |
differentiating,epithelium |
R820 |
T1381 |
T1379 |
pobj |
epithelium,in |
R821 |
T1382 |
T1381 |
compound |
lens,epithelium |
R822 |
T1383 |
T1376 |
cc |
and,increased |
R823 |
T1384 |
T1385 |
aux |
have,suggested |
R824 |
T1385 |
T1376 |
conj |
suggested,increased |
R825 |
T1386 |
T1385 |
auxpass |
been,suggested |
R826 |
T1387 |
T1385 |
prep |
as,suggested |
R827 |
T1388 |
T1389 |
det |
a,marker |
R828 |
T1389 |
T1387 |
pobj |
marker,as |
R829 |
T1390 |
T1389 |
amod |
pan-specific,marker |
R830 |
T1391 |
T1389 |
prep |
for,marker |
R831 |
T1392 |
T1393 |
compound |
lens,fiber |
R832 |
T1393 |
T1394 |
compound |
fiber,development |
R833 |
T1394 |
T1391 |
pobj |
development,for |
R834 |
T1395 |
T1396 |
punct |
[,17 |
R835 |
T1396 |
T1376 |
parataxis |
17,increased |
R836 |
T1397 |
T1396 |
punct |
],17 |
R837 |
T1398 |
T1376 |
punct |
.,increased |
R838 |
T1400 |
T1401 |
compound |
Alpha,crystallin |
R839 |
T1401 |
T1403 |
nsubjpass |
crystallin,shown |
R840 |
T1402 |
T1401 |
punct |
-,crystallin |
R841 |
T1404 |
T1403 |
aux |
has,shown |
R842 |
T1405 |
T1403 |
advmod |
also,shown |
R843 |
T1406 |
T1403 |
auxpass |
been,shown |
R844 |
T1407 |
T1408 |
aux |
to,interact |
R845 |
T1408 |
T1403 |
xcomp |
interact,shown |
R846 |
T1409 |
T1408 |
advmod |
directly,interact |
R847 |
T1410 |
T1408 |
prep |
with,interact |
R848 |
T1411 |
T1410 |
pobj |
DNA,with |
R849 |
T1412 |
T1413 |
punct |
[,18 |
R850 |
T1413 |
T1403 |
parataxis |
18,shown |
R851 |
T1414 |
T1413 |
punct |
],18 |
R852 |
T1415 |
T1403 |
punct |
.,shown |
R853 |
T1417 |
T1418 |
prep |
In,shown |
R854 |
T1419 |
T1420 |
amod |
transfected,cells |
R855 |
T1420 |
T1417 |
pobj |
cells,In |
R856 |
T1421 |
T1420 |
compound |
CHO,cells |
R857 |
T1422 |
T1418 |
punct |
", ",shown |
R858 |
T1423 |
T1418 |
nsubjpass |
alphaB,shown |
R859 |
T1424 |
T1418 |
aux |
has,shown |
R860 |
T1425 |
T1418 |
advmod |
also,shown |
R861 |
T1426 |
T1418 |
auxpass |
been,shown |
R862 |
T1427 |
T1428 |
aux |
to,localize |
R863 |
T1428 |
T1418 |
xcomp |
localize,shown |
R864 |
T1429 |
T1428 |
advmod |
ectopically,localize |
R865 |
T1430 |
T1428 |
prep |
to,localize |
R866 |
T1431 |
T1432 |
compound |
interphase,nuclei |
R867 |
T1432 |
T1430 |
pobj |
nuclei,to |
R868 |
T1433 |
T1428 |
punct |
", ",localize |
R869 |
T1434 |
T1428 |
advcl |
suggesting,localize |
R870 |
T1435 |
T1436 |
det |
a,role |
R871 |
T1436 |
T1434 |
dobj |
role,suggesting |
R872 |
T1437 |
T1436 |
prep |
for,role |
R873 |
T1438 |
T1439 |
det |
this,protein |
R874 |
T1439 |
T1437 |
pobj |
protein,for |
R875 |
T1440 |
T1436 |
prep |
in,role |
R876 |
T1441 |
T1442 |
det |
the,nucleus |
R877 |
T1442 |
T1440 |
pobj |
nucleus,in |
R878 |
T1443 |
T1444 |
punct |
[,19 |
R879 |
T1444 |
T1418 |
parataxis |
19,shown |
R880 |
T1445 |
T1444 |
punct |
],19 |
R881 |
T1446 |
T1418 |
punct |
.,shown |
R882 |
T1448 |
T1449 |
det |
A,role |
R883 |
T1449 |
T1451 |
nsubjpass |
role,supported |
R884 |
T1450 |
T1449 |
amod |
nuclear,role |
R885 |
T1452 |
T1449 |
prep |
for,role |
R886 |
T1453 |
T1452 |
pobj |
alphaB,for |
R887 |
T1454 |
T1449 |
prep |
in,role |
R888 |
T1455 |
T1456 |
det |
the,lens |
R889 |
T1456 |
T1454 |
pobj |
lens,in |
R890 |
T1457 |
T1451 |
auxpass |
was,supported |
R891 |
T1458 |
T1451 |
agent |
by,supported |
R892 |
T1459 |
T1460 |
det |
the,findings |
R893 |
T1460 |
T1458 |
pobj |
findings,by |
R894 |
T1461 |
T1462 |
mark |
that,demonstrated |
R895 |
T1462 |
T1460 |
acl |
demonstrated,findings |
R896 |
T1463 |
T1464 |
det |
a,subset |
R897 |
T1464 |
T1462 |
nsubj |
subset,demonstrated |
R898 |
T1465 |
T1464 |
prep |
of,subset |
R899 |
T1466 |
T1467 |
nmod |
lens,cells |
R900 |
T1467 |
T1465 |
pobj |
cells,of |
R901 |
T1468 |
T1467 |
amod |
epithelial,cells |
R902 |
T1469 |
T1467 |
acl |
derived,cells |
R903 |
T1470 |
T1469 |
prep |
from,derived |
R904 |
T1471 |
T1472 |
compound |
alphaB,mice |
R905 |
T1472 |
T1470 |
pobj |
mice,from |
R906 |
T1473 |
T1472 |
compound |
knockout,mice |
R907 |
T1474 |
T1462 |
dobj |
hyperproliferation,demonstrated |
R908 |
T1475 |
T1474 |
cc |
and,hyperproliferation |
R909 |
T1476 |
T1477 |
amod |
genomic,instability |
R910 |
T1477 |
T1474 |
conj |
instability,hyperproliferation |
R911 |
T1478 |
T1479 |
punct |
[,20 |
R912 |
T1479 |
T1451 |
parataxis |
20,supported |
R913 |
T1480 |
T1479 |
punct |
],20 |
R914 |
T1481 |
T1451 |
punct |
.,supported |
R915 |
T1483 |
T1484 |
prep |
In,resulted |
R916 |
T1485 |
T1483 |
pobj |
addition,In |
R917 |
T1486 |
T1484 |
punct |
", ",resulted |
R918 |
T1487 |
T1488 |
det |
the,administration |
R919 |
T1488 |
T1484 |
nsubj |
administration,resulted |
R920 |
T1489 |
T1488 |
prep |
of,administration |
R921 |
T1490 |
T1491 |
amod |
exogenous,crystallin |
R922 |
T1491 |
T1489 |
pobj |
crystallin,of |
R923 |
T1492 |
T1491 |
compound |
alpha,crystallin |
R924 |
T1493 |
T1491 |
punct |
-,crystallin |
R925 |
T1494 |
T1488 |
prep |
to,administration |
R926 |
T1495 |
T1496 |
amod |
primary,cultures |
R927 |
T1496 |
T1494 |
pobj |
cultures,to |
R928 |
T1497 |
T1498 |
amod |
bovine,lens |
R929 |
T1498 |
T1499 |
nmod |
lens,cell |
R930 |
T1499 |
T1496 |
compound |
cell,cultures |
R931 |
T1500 |
T1499 |
amod |
epithelial,cell |
R932 |
T1501 |
T1484 |
prep |
in,resulted |
R933 |
T1502 |
T1503 |
det |
the,formation |
R934 |
T1503 |
T1501 |
pobj |
formation,in |
R935 |
T1504 |
T1503 |
prep |
of,formation |
R936 |
T1505 |
T1506 |
amod |
lentoid,bodies |
R937 |
T1506 |
T1504 |
pobj |
bodies,of |
R938 |
T1507 |
T1484 |
punct |
", ",resulted |
R939 |
T1508 |
T1484 |
advcl |
consistent,resulted |
R940 |
T1509 |
T1508 |
prep |
with,consistent |
R941 |
T1510 |
T1511 |
det |
a,role |
R942 |
T1511 |
T1509 |
pobj |
role,with |
R943 |
T1512 |
T1511 |
prep |
for,role |
R944 |
T1513 |
T1514 |
det |
these,proteins |
R945 |
T1514 |
T1512 |
pobj |
proteins,for |
R946 |
T1515 |
T1511 |
prep |
in,role |
R947 |
T1516 |
T1517 |
compound |
lens,differentiation |
R948 |
T1517 |
T1515 |
pobj |
differentiation,in |
R949 |
T1518 |
T1519 |
punct |
[,21 |
R950 |
T1519 |
T1484 |
parataxis |
21,resulted |
R951 |
T1520 |
T1519 |
punct |
],21 |
R952 |
T1521 |
T1484 |
punct |
.,resulted |
R953 |
T1523 |
T1524 |
det |
These,findings |
R954 |
T1524 |
T1525 |
nsubj |
findings,indicate |
R955 |
T1526 |
T1527 |
mark |
that,have |
R957 |
T1527 |
T1525 |
ccomp |
have,indicate |
R959 |
T1528 |
T1529 |
compound |
alpha,crystallin |
R963 |
T1529 |
T1527 |
nsubj |
crystallin,have |
R969 |
T1530 |
T1529 |
punct |
-,crystallin |
R972 |
T1531 |
T1527 |
aux |
may,have |
R974 |
T1532 |
T1533 |
det |
a,multitude |
R978 |
T1533 |
T1527 |
dobj |
multitude,have |
R983 |
T1534 |
T1533 |
prep |
of,multitude |
R987 |
T1535 |
T1536 |
advmod |
in,vivo |
R990 |
T1536 |
T1537 |
amod |
vivo,functions |
R994 |
T1537 |
T1534 |
pobj |
functions,of |
R997 |
T1538 |
T1525 |
punct |
.,indicate |