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PMC:149350 / 32456-33743 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T7740 0-5 EX denotes There
T7741 6-8 VBZ denotes is
T7742 9-18 JJ denotes extensive
T7743 19-27 NN denotes evidence
T7744 28-32 IN denotes from
T7745 33-41 JJ denotes previous
T7746 42-49 NNS denotes studies
T7747 50-63 VBG denotes demonstrating
T7748 64-68 IN denotes that
T7750 69-74 NN denotes alpha
T7752 74-75 HYPH denotes -
T7751 75-85 NN denotes crystallin
T7749 86-91 VBZ denotes plays
T7753 92-93 DT denotes a
T7754 94-98 NN denotes role
T7755 99-101 IN denotes in
T7756 102-105 DT denotes the
T7758 106-118 JJ denotes cytoskeletal
T7757 119-131 NN denotes organization
T7759 131-132 . denotes .
T7760 132-224 sentence denotes Both alphaA and alphaB can bind specifically to actin, both in vitro [13] and in vivo [14].
T7761 133-137 CC denotes Both
T7762 138-144 NN denotes alphaA
T7764 145-148 CC denotes and
T7765 149-155 NN denotes alphaB
T7766 156-159 MD denotes can
T7763 160-164 VB denotes bind
T7767 165-177 RB denotes specifically
T7768 178-180 IN denotes to
T7769 181-186 NN denotes actin
T7770 186-188 , denotes ,
T7771 188-192 CC denotes both
T7773 193-195 FW denotes in
T7774 196-201 FW denotes vitro
T7775 202-203 -LRB- denotes [
T7772 203-205 CD denotes 13
T7776 205-206 -RRB- denotes ]
T7777 207-210 CC denotes and
T7778 211-213 FW denotes in
T7780 214-218 FW denotes vivo
T7781 219-220 -LRB- denotes [
T7779 220-222 CD denotes 14
T7782 222-223 -RRB- denotes ]
T7783 223-224 . denotes .
T7784 224-437 sentence denotes Actin filament formation has been shown to be necessary for the differentiation of lens epithelial cells [15], however, the significance of alpha-crystallin interaction with actin in differentiation is not known.
T7785 225-230 NN denotes Actin
T7786 231-239 NN denotes filament
T7787 240-249 NN denotes formation
T7789 250-253 VBZ denotes has
T7790 254-258 VBN denotes been
T7788 259-264 VBN denotes shown
T7792 265-267 TO denotes to
T7793 268-270 VB denotes be
T7794 271-280 JJ denotes necessary
T7795 281-284 IN denotes for
T7796 285-288 DT denotes the
T7797 289-304 NN denotes differentiation
T7798 305-307 IN denotes of
T7799 308-312 NN denotes lens
T7801 313-323 JJ denotes epithelial
T7800 324-329 NNS denotes cells
T7802 330-331 -LRB- denotes [
T7803 331-333 CD denotes 15
T7804 333-334 -RRB- denotes ]
T7805 334-336 , denotes ,
T7806 336-343 RB denotes however
T7807 343-345 , denotes ,
T7808 345-348 DT denotes the
T7809 349-361 NN denotes significance
T7810 362-364 IN denotes of
T7811 365-370 NN denotes alpha
T7813 370-371 HYPH denotes -
T7812 371-381 NN denotes crystallin
T7814 382-393 NN denotes interaction
T7815 394-398 IN denotes with
T7816 399-404 NN denotes actin
T7817 405-407 IN denotes in
T7818 408-423 NN denotes differentiation
T7819 424-426 VBZ denotes is
T7820 427-430 RB denotes not
T7791 431-436 VBN denotes known
T7821 436-437 . denotes .
T7822 437-653 sentence denotes In the lens, alpha-crystallin also forms a complex with type III intermediate filament proteins and the lens-specific beaded filament proteins CP49 and CP115, which may be critical for proper filament assembly [16].
T7823 438-440 IN denotes In
T7825 441-444 DT denotes the
T7826 445-449 NN denotes lens
T7827 449-451 , denotes ,
T7828 451-456 NN denotes alpha
T7830 456-457 HYPH denotes -
T7829 457-467 NN denotes crystallin
T7831 468-472 RB denotes also
T7824 473-478 VBZ denotes forms
T7832 479-480 DT denotes a
T7833 481-488 NN denotes complex
T7834 489-493 IN denotes with
T7835 494-498 NN denotes type
T7837 499-502 CD denotes III
T7838 503-515 JJ denotes intermediate
T7839 516-524 NN denotes filament
T7836 525-533 NN denotes proteins
T7840 534-537 CC denotes and
T7841 538-541 DT denotes the
T7843 542-546 NN denotes lens
T7845 546-547 HYPH denotes -
T7844 547-555 JJ denotes specific
T7846 556-562 VBN denotes beaded
T7847 563-571 NN denotes filament
T7842 572-580 NN denotes proteins
T7848 581-585 NN denotes CP49
T7849 586-589 CC denotes and
T7850 590-595 NN denotes CP115
T7851 595-597 , denotes ,
T7852 597-602 WDT denotes which
T7854 603-606 MD denotes may
T7853 607-609 VB denotes be
T7855 610-618 JJ denotes critical
T7856 619-622 IN denotes for
T7857 623-629 JJ denotes proper
T7859 630-638 NN denotes filament
T7858 639-647 NN denotes assembly
T7860 648-649 -LRB- denotes [
T7861 649-651 CD denotes 16
T7862 651-652 -RRB- denotes ]
T7863 652-653 . denotes .
T7864 653-816 sentence denotes Beaded filament mRNA levels increase greatly in differentiating lens epithelial cells, and have been suggested as a pan-specific marker for lens fiber cells [17].
T7865 654-660 VBN denotes Beaded
T7866 661-669 NN denotes filament
T7868 670-674 NN denotes mRNA
T7867 675-681 NNS denotes levels
T7869 682-690 VBP denotes increase
T7870 691-698 RB denotes greatly
T7871 699-701 IN denotes in
T7872 702-717 VBG denotes differentiating
T7874 718-722 NN denotes lens
T7875 723-733 JJ denotes epithelial
T7873 734-739 NNS denotes cells
T7876 739-741 , denotes ,
T7877 741-744 CC denotes and
T7878 745-749 VBP denotes have
T7880 750-754 VBN denotes been
T7879 755-764 VBN denotes suggested
T7881 765-767 IN denotes as
T7882 768-769 DT denotes a
T7884 770-782 JJ denotes pan-specific
T7883 783-789 NN denotes marker
T7885 790-793 IN denotes for
T7886 794-798 NN denotes lens
T7887 799-804 NN denotes fiber
T7888 805-810 NNS denotes cells
T7889 811-812 -LRB- denotes [
T7890 812-814 CD denotes 17
T7891 814-815 -RRB- denotes ]
T7892 815-816 . denotes .
T7893 816-1054 sentence denotes It is therefore possible that increased synthesis of alpha-crystallin in epithelial cells early in the differentiation process may have profound effects upon the cytoskeleton, which in turn may profoundly affect cell shape and migration.
T7894 817-819 PRP denotes It
T7895 820-822 VBZ denotes is
T7896 823-832 RB denotes therefore
T7897 833-841 JJ denotes possible
T7898 842-846 IN denotes that
T7900 847-856 VBN denotes increased
T7901 857-866 NN denotes synthesis
T7902 867-869 IN denotes of
T7903 870-875 NN denotes alpha
T7905 875-876 HYPH denotes -
T7904 876-886 NN denotes crystallin
T7906 887-889 IN denotes in
T7907 890-900 JJ denotes epithelial
T7908 901-906 NNS denotes cells
T7909 907-912 RB denotes early
T7910 913-915 IN denotes in
T7911 916-919 DT denotes the
T7913 920-935 NN denotes differentiation
T7912 936-943 NN denotes process
T7914 944-947 MD denotes may
T7899 948-952 VB denotes have
T7915 953-961 JJ denotes profound
T7916 962-969 NNS denotes effects
T7917 970-974 IN denotes upon
T7918 975-978 DT denotes the
T7919 979-991 NN denotes cytoskeleton
T7920 991-993 , denotes ,
T7921 993-998 WDT denotes which
T7923 999-1001 IN denotes in
T7924 1002-1006 NN denotes turn
T7925 1007-1010 MD denotes may
T7926 1011-1021 RB denotes profoundly
T7922 1022-1028 VB denotes affect
T7927 1029-1033 NN denotes cell
T7928 1034-1039 NN denotes shape
T7929 1040-1043 CC denotes and
T7930 1044-1053 NN denotes migration
T7931 1053-1054 . denotes .
T7932 1054-1190 sentence denotes The lack of cellar organization and uniform cell shape at the equatorial region observed in alphaA/BKO lenses supports this hypothesis.
T7933 1055-1058 DT denotes The
T7934 1059-1063 NN denotes lack
T7936 1064-1066 IN denotes of
T7937 1067-1073 JJ denotes cellar
T7938 1074-1086 NN denotes organization
T7939 1087-1090 CC denotes and
T7940 1091-1098 JJ denotes uniform
T7942 1099-1103 NN denotes cell
T7941 1104-1109 NN denotes shape
T7943 1110-1112 IN denotes at
T7944 1113-1116 DT denotes the
T7946 1117-1127 JJ denotes equatorial
T7945 1128-1134 NN denotes region
T7947 1135-1143 VBN denotes observed
T7948 1144-1146 IN denotes in
T7949 1147-1153 NN denotes alphaA
T7951 1153-1154 HYPH denotes /
T7950 1154-1157 NN denotes BKO
T7952 1158-1164 NNS denotes lenses
T7935 1165-1173 VBZ denotes supports
T7953 1174-1178 DT denotes this
T7954 1179-1189 NN denotes hypothesis
T7955 1189-1190 . denotes .
T7956 1190-1287 sentence denotes Studies are currently underway to characterize cytoskeletal organization in the alphaA/BKO lens.
T7957 1191-1198 NNS denotes Studies
T7958 1199-1202 VBP denotes are
T7959 1203-1212 RB denotes currently
T7960 1213-1221 JJ denotes underway
T7961 1222-1224 TO denotes to
T7962 1225-1237 VB denotes characterize
T7963 1238-1250 JJ denotes cytoskeletal
T7964 1251-1263 NN denotes organization
T7965 1264-1266 IN denotes in
T7966 1267-1270 DT denotes the
T7968 1271-1277 NN denotes alphaA
T7970 1277-1278 HYPH denotes /
T7969 1278-1281 NN denotes BKO
T7967 1282-1286 NN denotes lens
T7971 1286-1287 . denotes .
R5325 T7828 T7829 compound alpha,crystallin
R5327 T7829 T7824 nsubj crystallin,forms
R5328 T7830 T7829 punct -,crystallin
R5329 T7831 T7824 advmod also,forms
R5331 T7832 T7833 det a,complex
R5332 T7833 T7824 dobj complex,forms
R5333 T7834 T7824 prep with,forms
R5335 T7835 T7836 nmod type,proteins
R5336 T7836 T7834 pobj proteins,with
R5337 T7837 T7835 nummod III,type
R5339 T7838 T7839 amod intermediate,filament
R5340 T7839 T7836 compound filament,proteins
R5341 T7840 T7836 cc and,proteins
R5343 T7841 T7842 det the,proteins
R5344 T7842 T7836 conj proteins,proteins
R5345 T7843 T7844 npadvmod lens,specific
R5347 T7844 T7842 amod specific,proteins
R5348 T7845 T7844 punct -,specific
R5350 T7846 T7847 amod beaded,filament
R5351 T7847 T7842 compound filament,proteins
R5352 T7848 T7842 appos CP49,proteins
R5353 T7740 T7741 expl There,is
R5354 T7849 T7848 cc and,CP49
R5355 T7850 T7848 conj CP115,CP49
R5356 T7851 T7824 punct ", ",forms
R5357 T7852 T7853 dep which,be
R5358 T7853 T7824 advcl be,forms
R5359 T7854 T7853 aux may,be
R5360 T7855 T7853 acomp critical,be
R5361 T7856 T7855 prep for,critical
R5362 T7742 T7743 amod extensive,evidence
R5363 T7857 T7858 amod proper,assembly
R5364 T7858 T7856 pobj assembly,for
R5365 T7859 T7858 compound filament,assembly
R5366 T7860 T7861 punct [,16
R5367 T7743 T7741 attr evidence,is
R5368 T7861 T7824 parataxis 16,forms
R5369 T7862 T7861 punct ],16
R5370 T7863 T7824 punct .,forms
R5371 T7744 T7743 prep from,evidence
R5372 T7865 T7866 amod Beaded,filament
R5373 T7866 T7867 compound filament,levels
R5374 T7745 T7746 amod previous,studies
R5375 T7867 T7869 nsubj levels,increase
R5376 T7868 T7867 compound mRNA,levels
R5377 T7746 T7744 pobj studies,from
R5378 T7870 T7869 advmod greatly,increase
R5379 T7871 T7869 prep in,increase
R5380 T7747 T7743 acl demonstrating,evidence
R5381 T7872 T7873 amod differentiating,cells
R5382 T7748 T7749 mark that,plays
R5383 T7873 T7871 pobj cells,in
R5384 T7749 T7747 ccomp plays,demonstrating
R5385 T7874 T7873 nmod lens,cells
R5386 T7875 T7873 amod epithelial,cells
R5387 T7876 T7869 punct ", ",increase
R5388 T7750 T7751 compound alpha,crystallin
R5389 T7877 T7869 cc and,increase
R5390 T7878 T7879 aux have,suggested
R5391 T7879 T7869 conj suggested,increase
R5392 T7751 T7749 nsubj crystallin,plays
R5393 T7880 T7879 auxpass been,suggested
R5394 T7881 T7879 prep as,suggested
R5395 T7752 T7751 punct -,crystallin
R5396 T7882 T7883 det a,marker
R5397 T7883 T7881 pobj marker,as
R5398 T7753 T7754 det a,role
R5399 T7884 T7883 amod pan-specific,marker
R5400 T7885 T7883 prep for,marker
R5401 T7886 T7887 compound lens,fiber
R5402 T7754 T7749 dobj role,plays
R5403 T7887 T7888 compound fiber,cells
R5404 T7888 T7885 pobj cells,for
R5405 T7889 T7890 punct [,17
R5406 T7755 T7749 prep in,plays
R5407 T7890 T7879 parataxis 17,suggested
R5408 T7891 T7890 punct ],17
R5409 T7892 T7869 punct .,increase
R5410 T7894 T7895 nsubj It,is
R5411 T7756 T7757 det the,organization
R5412 T7896 T7895 advmod therefore,is
R5413 T7897 T7895 acomp possible,is
R5414 T7757 T7755 pobj organization,in
R5415 T7898 T7899 mark that,have
R5416 T7899 T7895 ccomp have,is
R5417 T7900 T7901 amod increased,synthesis
R5418 T7901 T7899 nsubj synthesis,have
R5419 T7758 T7757 amod cytoskeletal,organization
R5420 T7902 T7901 prep of,synthesis
R5421 T7903 T7904 compound alpha,crystallin
R5422 T7904 T7902 pobj crystallin,of
R5423 T7759 T7741 punct .,is
R5424 T7905 T7904 punct -,crystallin
R5425 T7906 T7901 prep in,synthesis
R5426 T7907 T7908 amod epithelial,cells
R5427 T7761 T7762 preconj Both,alphaA
R5428 T7908 T7906 pobj cells,in
R5429 T7909 T7901 advmod early,synthesis
R5430 T7910 T7909 prep in,early
R5431 T7762 T7763 nsubj alphaA,bind
R5432 T7911 T7912 det the,process
R5433 T7912 T7910 pobj process,in
R5434 T7913 T7912 compound differentiation,process
R5435 T7914 T7899 aux may,have
R5436 T7764 T7762 cc and,alphaA
R5437 T7915 T7916 amod profound,effects
R5438 T7916 T7899 dobj effects,have
R5439 T7917 T7899 prep upon,have
R5440 T7765 T7762 conj alphaB,alphaA
R5441 T7918 T7919 det the,cytoskeleton
R5442 T7919 T7917 pobj cytoskeleton,upon
R5443 T7920 T7919 punct ", ",cytoskeleton
R5444 T7766 T7763 aux can,bind
R5445 T7921 T7922 dep which,affect
R5446 T7922 T7919 relcl affect,cytoskeleton
R5447 T7923 T7922 prep in,affect
R5448 T7767 T7763 advmod specifically,bind
R5449 T7924 T7923 pobj turn,in
R5450 T7925 T7922 aux may,affect
R5451 T7768 T7763 prep to,bind
R5452 T7769 T7768 pobj actin,to
R5453 T7926 T7922 advmod profoundly,affect
R5454 T7770 T7763 punct ", ",bind
R5455 T7927 T7928 compound cell,shape
R5456 T7928 T7922 dobj shape,affect
R5457 T7771 T7772 preconj both,13
R5458 T7929 T7928 cc and,shape
R5459 T7930 T7928 conj migration,shape
R5460 T7772 T7763 advmod 13,bind
R5461 T7931 T7895 punct .,is
R5462 T7933 T7934 det The,lack
R5463 T7773 T7772 advmod in,13
R5464 T7774 T7772 advmod vitro,13
R5465 T7934 T7935 nsubj lack,supports
R5466 T7775 T7772 punct [,13
R5467 T7936 T7934 prep of,lack
R5468 T7776 T7772 punct ],13
R5469 T7937 T7938 amod cellar,organization
R5470 T7938 T7936 pobj organization,of
R5471 T7939 T7938 cc and,organization
R5472 T7777 T7772 cc and,13
R5473 T7940 T7941 amod uniform,shape
R5474 T7941 T7938 conj shape,organization
R5475 T7778 T7779 advmod in,14
R5476 T7942 T7941 compound cell,shape
R5477 T7943 T7934 prep at,lack
R5478 T7944 T7945 det the,region
R5479 T7779 T7772 conj 14,13
R5480 T7945 T7943 pobj region,at
R5481 T7946 T7945 amod equatorial,region
R5482 T7947 T7934 acl observed,lack
R5483 T7780 T7779 advmod vivo,14
R5484 T7948 T7947 prep in,observed
R5485 T7949 T7950 compound alphaA,BKO
R5486 T7781 T7779 punct [,14
R5487 T7950 T7952 compound BKO,lenses
R5488 T7951 T7950 punct /,BKO
R5489 T7952 T7948 pobj lenses,in
R5490 T7782 T7779 punct ],14
R5491 T7953 T7954 det this,hypothesis
R5492 T7954 T7935 dobj hypothesis,supports
R5493 T7955 T7935 punct .,supports
R5494 T7783 T7763 punct .,bind
R5495 T7957 T7958 nsubj Studies,are
R5496 T7785 T7786 compound Actin,filament
R5497 T7959 T7960 advmod currently,underway
R5498 T7960 T7958 acomp underway,are
R5499 T7786 T7787 compound filament,formation
R5500 T7787 T7788 nsubjpass formation,shown
R5501 T7788 T7791 ccomp shown,known
R5502 T7961 T7962 aux to,characterize
R5503 T7789 T7788 aux has,shown
R5504 T7962 T7958 advcl characterize,are
R5505 T7963 T7964 amod cytoskeletal,organization
R5506 T7964 T7962 dobj organization,characterize
R5507 T7790 T7788 auxpass been,shown
R5508 T7965 T7962 prep in,characterize
R5509 T7966 T7967 det the,lens
R5510 T7792 T7793 aux to,be
R5511 T7967 T7965 pobj lens,in
R5512 T7968 T7969 compound alphaA,BKO
R5513 T7969 T7967 compound BKO,lens
R5514 T7970 T7969 punct /,BKO
R5515 T7971 T7958 punct .,are
R5516 T7793 T7788 xcomp be,shown
R5517 T7794 T7793 acomp necessary,be
R5518 T7795 T7794 prep for,necessary
R5519 T7796 T7797 det the,differentiation
R5520 T7797 T7795 pobj differentiation,for
R5521 T7798 T7797 prep of,differentiation
R5522 T7799 T7800 nmod lens,cells
R5523 T7800 T7798 pobj cells,of
R5524 T7801 T7800 amod epithelial,cells
R5525 T7802 T7803 punct [,15
R5526 T7803 T7788 parataxis 15,shown
R5527 T7804 T7803 punct ],15
R5528 T7805 T7791 punct ", ",known
R5529 T7806 T7791 advmod however,known
R5530 T7807 T7791 punct ", ",known
R5531 T7808 T7809 det the,significance
R5532 T7809 T7791 nsubjpass significance,known
R5533 T7810 T7809 prep of,significance
R5534 T7811 T7812 compound alpha,crystallin
R5535 T7812 T7814 compound crystallin,interaction
R5536 T7813 T7812 punct -,crystallin
R5537 T7814 T7810 pobj interaction,of
R5538 T7815 T7814 prep with,interaction
R5539 T7816 T7815 pobj actin,with
R5540 T7817 T7814 prep in,interaction
R5541 T7818 T7817 pobj differentiation,in
R5542 T7819 T7791 auxpass is,known
R5543 T7820 T7791 neg not,known
R5544 T7821 T7791 punct .,known
R5545 T7823 T7824 prep In,forms
R5546 T7825 T7826 det the,lens
R5547 T7826 T7823 pobj lens,In
R5548 T7827 T7824 punct ", ",forms