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PMC:149350 / 26229-28915 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T6591 0-2 PRP denotes It
T6592 3-5 VBZ denotes is
T6593 6-14 JJ denotes unlikely
T6594 15-19 IN denotes that
T6596 20-25 DT denotes these
T6597 26-37 NNS denotes alterations
T6598 38-40 IN denotes in
T6599 41-47 NN denotes alphaA
T6601 47-48 HYPH denotes /
T6600 48-51 NN denotes BKO
T6603 52-57 NN denotes mouse
T6602 58-64 NNS denotes lenses
T6595 65-71 VBP denotes result
T6604 72-76 IN denotes from
T6605 77-86 VBN denotes increased
T6606 87-101 NN denotes susceptibility
T6607 102-104 IN denotes of
T6608 105-110 DT denotes these
T6609 111-117 NNS denotes lenses
T6610 118-120 IN denotes to
T6611 121-126 NN denotes light
T6613 126-127 HYPH denotes -
T6612 127-134 VBN denotes induced
T6614 135-141 NN denotes damage
T6615 142-144 IN denotes in
T6616 145-148 DT denotes the
T6617 149-156 NN denotes absence
T6618 157-159 IN denotes of
T6619 160-163 DT denotes the
T6621 164-173 JJ denotes molecular
T6622 174-183 NN denotes chaperone
T6620 184-194 NN denotes protection
T6623 195-203 VBN denotes afforded
T6624 204-206 IN denotes by
T6625 207-213 NN denotes alphaA
T6626 214-217 CC denotes and
T6627 218-224 NN denotes alphaB
T6628 225-227 IN denotes in
T6629 228-234 JJ denotes normal
T6630 235-241 NNS denotes lenses
T6631 241-242 . denotes .
T6632 242-438 sentence denotes With the normal time of eye opening at approximately 14 days after birth, the 5 wk old mice had their eyes open and lenses exposed to light for only about 3 weeks prior to morphological analysis.
T6633 243-247 IN denotes With
T6635 248-251 DT denotes the
T6637 252-258 JJ denotes normal
T6636 259-263 NN denotes time
T6638 264-266 IN denotes of
T6639 267-270 NN denotes eye
T6640 271-278 NN denotes opening
T6641 279-281 IN denotes at
T6642 282-295 RB denotes approximately
T6643 296-298 CD denotes 14
T6644 299-303 NNS denotes days
T6645 304-309 IN denotes after
T6646 310-315 NN denotes birth
T6647 315-317 , denotes ,
T6648 317-320 DT denotes the
T6650 321-322 CD denotes 5
T6651 323-325 NN denotes wk
T6652 326-329 JJ denotes old
T6649 330-334 NNS denotes mice
T6634 335-338 VBD denotes had
T6653 339-344 PRP$ denotes their
T6654 345-349 NNS denotes eyes
T6655 350-354 JJ denotes open
T6656 355-358 CC denotes and
T6657 359-365 NNS denotes lenses
T6658 366-373 VBN denotes exposed
T6659 374-376 IN denotes to
T6660 377-382 NN denotes light
T6661 383-386 IN denotes for
T6662 387-391 RB denotes only
T6664 392-397 RB denotes about
T6663 398-399 CD denotes 3
T6665 400-405 NNS denotes weeks
T6666 406-411 RB denotes prior
T6667 412-414 IN denotes to
T6668 415-428 JJ denotes morphological
T6669 429-437 NN denotes analysis
T6670 437-438 . denotes .
T6671 438-575 sentence denotes Moreover, these animals had been exposed to only animal facility fluorescent lighting and were protected from UV light by plastic cages.
T6672 439-447 RB denotes Moreover
T6674 447-449 , denotes ,
T6675 449-454 DT denotes these
T6676 455-462 NNS denotes animals
T6677 463-466 VBD denotes had
T6678 467-471 VBN denotes been
T6673 472-479 VBN denotes exposed
T6679 480-482 IN denotes to
T6680 483-487 RB denotes only
T6682 488-494 JJ denotes animal
T6683 495-503 NN denotes facility
T6684 504-515 JJ denotes fluorescent
T6681 516-524 NN denotes lighting
T6685 525-528 CC denotes and
T6687 529-533 VBD denotes were
T6686 534-543 VBN denotes protected
T6688 544-548 IN denotes from
T6689 549-551 NN denotes UV
T6690 552-557 NN denotes light
T6691 558-560 IN denotes by
T6692 561-568 JJ denotes plastic
T6693 569-574 NNS denotes cages
T6694 574-575 . denotes .
T6695 575-872 sentence denotes If lack of protection from light-induced damage was the major factor affecting the changes in these lenses, then the bulk of the damage should have resided along the visual axis, particularly in the central anterior epithelium and subcapsular cortex in the 5 wk lenses, but this was not the case.
T6696 576-578 IN denotes If
T6698 579-583 NN denotes lack
T6699 584-586 IN denotes of
T6700 587-597 NN denotes protection
T6701 598-602 IN denotes from
T6702 603-608 NN denotes light
T6704 608-609 HYPH denotes -
T6703 609-616 VBN denotes induced
T6705 617-623 NN denotes damage
T6697 624-627 VBD denotes was
T6707 628-631 DT denotes the
T6709 632-637 JJ denotes major
T6708 638-644 NN denotes factor
T6710 645-654 VBG denotes affecting
T6711 655-658 DT denotes the
T6712 659-666 NNS denotes changes
T6713 667-669 IN denotes in
T6714 670-675 DT denotes these
T6715 676-682 NNS denotes lenses
T6716 682-684 , denotes ,
T6717 684-688 RB denotes then
T6718 689-692 DT denotes the
T6719 693-697 NN denotes bulk
T6720 698-700 IN denotes of
T6721 701-704 DT denotes the
T6722 705-711 NN denotes damage
T6723 712-718 MD denotes should
T6724 719-723 VB denotes have
T6706 724-731 VBN denotes resided
T6725 732-737 IN denotes along
T6726 738-741 DT denotes the
T6728 742-748 JJ denotes visual
T6727 749-753 NN denotes axis
T6729 753-755 , denotes ,
T6730 755-767 RB denotes particularly
T6731 768-770 IN denotes in
T6732 771-774 DT denotes the
T6734 775-782 JJ denotes central
T6735 783-791 JJ denotes anterior
T6733 792-802 NN denotes epithelium
T6736 803-806 CC denotes and
T6737 807-818 JJ denotes subcapsular
T6738 819-825 NN denotes cortex
T6739 826-828 IN denotes in
T6740 829-832 DT denotes the
T6742 833-834 CD denotes 5
T6743 835-837 NN denotes wk
T6741 838-844 NNS denotes lenses
T6744 844-846 , denotes ,
T6745 846-849 CC denotes but
T6746 850-854 DT denotes this
T6747 855-858 VBD denotes was
T6748 859-862 RB denotes not
T6749 863-866 DT denotes the
T6750 867-871 NN denotes case
T6751 871-872 . denotes .
T6752 872-984 sentence denotes In these lenses, gross morphological changes were apparent in the equatorial and posterior subcapsular regions.
T6753 873-875 IN denotes In
T6755 876-881 DT denotes these
T6756 882-888 NNS denotes lenses
T6757 888-890 , denotes ,
T6758 890-895 JJ denotes gross
T6760 896-909 JJ denotes morphological
T6759 910-917 NNS denotes changes
T6754 918-922 VBD denotes were
T6761 923-931 JJ denotes apparent
T6762 932-934 IN denotes in
T6763 935-938 DT denotes the
T6765 939-949 JJ denotes equatorial
T6766 950-953 CC denotes and
T6767 954-963 JJ denotes posterior
T6768 964-975 JJ denotes subcapsular
T6764 976-983 NNS denotes regions
T6769 983-984 . denotes .
T6770 984-1189 sentence denotes These changes included posterior subcapsular nucleic acid staining, absence of posterior sutures, and small irregularly shaped cells, not arranged in any discernable pattern, in the equatorial/bow region.
T6771 985-990 DT denotes These
T6772 991-998 NNS denotes changes
T6773 999-1007 VBD denotes included
T6774 1008-1017 JJ denotes posterior
T6776 1018-1029 JJ denotes subcapsular
T6777 1030-1037 JJ denotes nucleic
T6778 1038-1042 NN denotes acid
T6775 1043-1051 NN denotes staining
T6779 1051-1053 , denotes ,
T6780 1053-1060 NN denotes absence
T6781 1061-1063 IN denotes of
T6782 1064-1073 JJ denotes posterior
T6783 1074-1081 NNS denotes sutures
T6784 1081-1083 , denotes ,
T6785 1083-1086 CC denotes and
T6786 1087-1092 JJ denotes small
T6788 1093-1104 RB denotes irregularly
T6789 1105-1111 VBN denotes shaped
T6787 1112-1117 NNS denotes cells
T6790 1117-1119 , denotes ,
T6791 1119-1122 RB denotes not
T6792 1123-1131 VBN denotes arranged
T6793 1132-1134 IN denotes in
T6794 1135-1138 DT denotes any
T6796 1139-1150 JJ denotes discernable
T6795 1151-1158 NN denotes pattern
T6797 1158-1160 , denotes ,
T6798 1160-1162 IN denotes in
T6799 1163-1166 DT denotes the
T6801 1167-1177 JJ denotes equatorial
T6803 1177-1178 HYPH denotes /
T6802 1178-1181 JJ denotes bow
T6800 1182-1188 NN denotes region
T6804 1188-1189 . denotes .
T6805 1189-1401 sentence denotes Systemic stress factors crossing the blood/aqueous barrier might explain some morphological changes at the equatorial region, but this would not explain nucleic acid staining in the posterior subcapsular region.
T6806 1190-1198 JJ denotes Systemic
T6807 1199-1205 NN denotes stress
T6808 1206-1213 NNS denotes factors
T6810 1214-1222 VBG denotes crossing
T6811 1223-1226 DT denotes the
T6813 1227-1232 NN denotes blood
T6815 1232-1233 HYPH denotes /
T6814 1233-1240 JJ denotes aqueous
T6812 1241-1248 NN denotes barrier
T6816 1249-1254 MD denotes might
T6809 1255-1262 VB denotes explain
T6817 1263-1267 DT denotes some
T6819 1268-1281 JJ denotes morphological
T6818 1282-1289 NNS denotes changes
T6820 1290-1292 IN denotes at
T6821 1293-1296 DT denotes the
T6823 1297-1307 JJ denotes equatorial
T6822 1308-1314 NN denotes region
T6824 1314-1316 , denotes ,
T6825 1316-1319 CC denotes but
T6826 1320-1324 DT denotes this
T6828 1325-1330 MD denotes would
T6829 1331-1334 RB denotes not
T6827 1335-1342 VB denotes explain
T6830 1343-1350 JJ denotes nucleic
T6831 1351-1355 NN denotes acid
T6832 1356-1364 NN denotes staining
T6833 1365-1367 IN denotes in
T6834 1368-1371 DT denotes the
T6836 1372-1381 JJ denotes posterior
T6837 1382-1393 JJ denotes subcapsular
T6835 1394-1400 NN denotes region
T6838 1400-1401 . denotes .
T6839 1401-1657 sentence denotes In the 5 wk alphaA/BKO lenses, nucleic acid staining in the posterior subcapsular region is consistent with either anterior epithelial cells migrating aberrantly to the posterior pole, or primary fiber cells failing to fully differentiate by 5 wks of age.
T6840 1402-1404 IN denotes In
T6842 1405-1408 DT denotes the
T6844 1409-1410 CD denotes 5
T6845 1411-1413 NN denotes wk
T6846 1414-1420 NN denotes alphaA
T6848 1420-1421 HYPH denotes /
T6847 1421-1424 NN denotes BKO
T6843 1425-1431 NNS denotes lenses
T6849 1431-1433 , denotes ,
T6850 1433-1440 JJ denotes nucleic
T6851 1441-1445 NN denotes acid
T6852 1446-1454 NN denotes staining
T6853 1455-1457 IN denotes in
T6854 1458-1461 DT denotes the
T6856 1462-1471 JJ denotes posterior
T6857 1472-1483 JJ denotes subcapsular
T6855 1484-1490 NN denotes region
T6841 1491-1493 VBZ denotes is
T6858 1494-1504 JJ denotes consistent
T6859 1505-1509 IN denotes with
T6860 1510-1516 CC denotes either
T6862 1517-1525 JJ denotes anterior
T6863 1526-1536 JJ denotes epithelial
T6861 1537-1542 NNS denotes cells
T6864 1543-1552 VBG denotes migrating
T6865 1553-1563 RB denotes aberrantly
T6866 1564-1566 IN denotes to
T6867 1567-1570 DT denotes the
T6869 1571-1580 JJ denotes posterior
T6868 1581-1585 NN denotes pole
T6870 1585-1587 , denotes ,
T6871 1587-1589 CC denotes or
T6872 1590-1597 JJ denotes primary
T6874 1598-1603 NN denotes fiber
T6873 1604-1609 NNS denotes cells
T6875 1610-1617 VBG denotes failing
T6876 1618-1620 TO denotes to
T6878 1621-1626 RB denotes fully
T6877 1627-1640 VB denotes differentiate
T6879 1641-1643 IN denotes by
T6880 1644-1645 CD denotes 5
T6881 1646-1649 NNS denotes wks
T6882 1650-1652 IN denotes of
T6883 1653-1656 NN denotes age
T6884 1656-1657 . denotes .
T6885 1657-1787 sentence denotes These two possibilities could not be differentiated in the methods employed, and were beyond the objectives of the current study.
T6886 1658-1663 DT denotes These
T6888 1664-1667 CD denotes two
T6887 1668-1681 NNS denotes possibilities
T6890 1682-1687 MD denotes could
T6891 1688-1691 RB denotes not
T6892 1692-1694 VB denotes be
T6889 1695-1709 VBN denotes differentiated
T6893 1710-1712 IN denotes in
T6894 1713-1716 DT denotes the
T6895 1717-1724 NNS denotes methods
T6896 1725-1733 VBN denotes employed
T6897 1733-1735 , denotes ,
T6898 1735-1738 CC denotes and
T6899 1739-1743 VBD denotes were
T6900 1744-1750 IN denotes beyond
T6901 1751-1754 DT denotes the
T6902 1755-1765 NNS denotes objectives
T6903 1766-1768 IN denotes of
T6904 1769-1772 DT denotes the
T6906 1773-1780 JJ denotes current
T6905 1781-1786 NN denotes study
T6907 1786-1787 . denotes .
T6908 1787-1934 sentence denotes Future studies are being designed to address which of these two processes might explain nucleic acid staining in the posterior subcapsular region.
T6909 1788-1794 JJ denotes Future
T6910 1795-1802 NNS denotes studies
T6912 1803-1806 VBP denotes are
T6913 1807-1812 VBG denotes being
T6911 1813-1821 VBN denotes designed
T6914 1822-1824 TO denotes to
T6915 1825-1832 VB denotes address
T6916 1833-1838 WDT denotes which
T6918 1839-1841 IN denotes of
T6919 1842-1847 DT denotes these
T6921 1848-1851 CD denotes two
T6920 1852-1861 NNS denotes processes
T6922 1862-1867 MD denotes might
T6917 1868-1875 VB denotes explain
T6923 1876-1883 JJ denotes nucleic
T6924 1884-1888 NN denotes acid
T6925 1889-1897 NN denotes staining
T6926 1898-1900 IN denotes in
T6927 1901-1904 DT denotes the
T6929 1905-1914 JJ denotes posterior
T6930 1915-1926 JJ denotes subcapsular
T6928 1927-1933 NN denotes region
T6931 1933-1934 . denotes .
T6932 1934-2047 sentence denotes Staining in this region was not observed in older alphaA/BKO lenses, suggesting that this pattern was transient.
T6933 1935-1943 VBG denotes Staining
T6935 1944-1946 IN denotes in
T6936 1947-1951 DT denotes this
T6937 1952-1958 NN denotes region
T6938 1959-1962 VBD denotes was
T6939 1963-1966 RB denotes not
T6934 1967-1975 VBN denotes observed
T6940 1976-1978 IN denotes in
T6941 1979-1984 JJR denotes older
T6943 1985-1991 NN denotes alphaA
T6945 1991-1992 HYPH denotes /
T6944 1992-1995 NN denotes BKO
T6942 1996-2002 NNS denotes lenses
T6946 2002-2004 , denotes ,
T6947 2004-2014 VBG denotes suggesting
T6948 2015-2019 IN denotes that
T6950 2020-2024 DT denotes this
T6951 2025-2032 NN denotes pattern
T6949 2033-2036 VBD denotes was
T6952 2037-2046 JJ denotes transient
T6953 2046-2047 . denotes .
T6954 2047-2218 sentence denotes The fate of the nucleic acid-containing cells in the posterior capsular region of younger lenses is not known at this time, nor is the morphology of earlier stage lenses.
T6955 2048-2051 DT denotes The
T6956 2052-2056 NN denotes fate
T6958 2057-2059 IN denotes of
T6959 2060-2063 DT denotes the
T6961 2064-2071 JJ denotes nucleic
T6962 2072-2076 NN denotes acid
T6964 2076-2077 HYPH denotes -
T6963 2077-2087 VBG denotes containing
T6960 2088-2093 NNS denotes cells
T6965 2094-2096 IN denotes in
T6966 2097-2100 DT denotes the
T6968 2101-2110 JJ denotes posterior
T6969 2111-2119 JJ denotes capsular
T6967 2120-2126 NN denotes region
T6970 2127-2129 IN denotes of
T6971 2130-2137 JJR denotes younger
T6972 2138-2144 NNS denotes lenses
T6973 2145-2147 VBZ denotes is
T6974 2148-2151 RB denotes not
T6957 2152-2157 VBN denotes known
T6975 2158-2160 IN denotes at
T6976 2161-2165 DT denotes this
T6977 2166-2170 NN denotes time
T6978 2170-2172 , denotes ,
T6979 2172-2175 CC denotes nor
T6980 2176-2178 VBZ denotes is
T6981 2179-2182 DT denotes the
T6982 2183-2193 NN denotes morphology
T6983 2194-2196 IN denotes of
T6984 2197-2204 JJR denotes earlier
T6985 2205-2210 NN denotes stage
T6986 2211-2217 NNS denotes lenses
T6987 2217-2218 . denotes .
T6988 2218-2364 sentence denotes Future studies with defined objectives to address the development and progression of morphological changes seen in this study are being designed.
T6989 2219-2225 JJ denotes Future
T6990 2226-2233 NNS denotes studies
T6992 2234-2238 IN denotes with
T6993 2239-2246 VBN denotes defined
T6994 2247-2257 NNS denotes objectives
T6995 2258-2260 TO denotes to
T6996 2261-2268 VB denotes address
T6997 2269-2272 DT denotes the
T6998 2273-2284 NN denotes development
T6999 2285-2288 CC denotes and
T7000 2289-2300 NN denotes progression
T7001 2301-2303 IN denotes of
T7002 2304-2317 JJ denotes morphological
T7003 2318-2325 NNS denotes changes
T7004 2326-2330 VBN denotes seen
T7005 2331-2333 IN denotes in
T7006 2334-2338 DT denotes this
T7007 2339-2344 NN denotes study
T7008 2345-2348 VBP denotes are
T7009 2349-2354 VBG denotes being
T6991 2355-2363 VBN denotes designed
T7010 2363-2364 . denotes .
T7011 2364-2592 sentence denotes The morphological differences in alphaA/BKO lenses, compared to age matched wild type lenses, were consistent with the hypothesis that alpha-crystallin plays an active role in the differentiation and growth of lens fiber cells.
T7012 2365-2368 DT denotes The
T7014 2369-2382 JJ denotes morphological
T7013 2383-2394 NNS denotes differences
T7016 2395-2397 IN denotes in
T7017 2398-2404 NN denotes alphaA
T7019 2404-2405 HYPH denotes /
T7018 2405-2408 NN denotes BKO
T7020 2409-2415 NNS denotes lenses
T7021 2415-2417 , denotes ,
T7022 2417-2425 VBN denotes compared
T7023 2426-2428 IN denotes to
T7024 2429-2432 NN denotes age
T7025 2433-2440 VBN denotes matched
T7027 2441-2445 JJ denotes wild
T7028 2446-2450 NN denotes type
T7026 2451-2457 NNS denotes lenses
T7029 2457-2459 , denotes ,
T7015 2459-2463 VBD denotes were
T7030 2464-2474 JJ denotes consistent
T7031 2475-2479 IN denotes with
T7032 2480-2483 DT denotes the
T7033 2484-2494 NN denotes hypothesis
T7034 2495-2499 IN denotes that
T7036 2500-2505 NN denotes alpha
T7038 2505-2506 HYPH denotes -
T7037 2506-2516 NN denotes crystallin
T7035 2517-2522 VBZ denotes plays
T7039 2523-2525 DT denotes an
T7041 2526-2532 JJ denotes active
T7040 2533-2537 NN denotes role
T7042 2538-2540 IN denotes in
T7043 2541-2544 DT denotes the
T7044 2545-2560 NN denotes differentiation
T7045 2561-2564 CC denotes and
T7046 2565-2571 NN denotes growth
T7047 2572-2574 IN denotes of
T7048 2575-2579 NN denotes lens
T7049 2580-2585 NN denotes fiber
T7050 2586-2591 NNS denotes cells
T7051 2591-2592 . denotes .
T7052 2592-2686 sentence denotes In addition, it was clearly evident that alpha-crystallin is necessary for lens transparency.
T7053 2593-2595 IN denotes In
T7055 2596-2604 NN denotes addition
T7056 2604-2606 , denotes ,
T7057 2606-2608 PRP denotes it
T7054 2609-2612 VBD denotes was
T7058 2613-2620 RB denotes clearly
T7059 2621-2628 JJ denotes evident
T7060 2629-2633 IN denotes that
T7062 2634-2639 NN denotes alpha
T7064 2639-2640 HYPH denotes -
T7063 2640-2650 NN denotes crystallin
T7061 2651-2653 VBZ denotes is
T7065 2654-2663 JJ denotes necessary
T7066 2664-2667 IN denotes for
T7067 2668-2672 NN denotes lens
T7068 2673-2685 NN denotes transparency
T7069 2685-2686 . denotes .
R4257 T6591 T6592 nsubj It,is
R4258 T6593 T6592 acomp unlikely,is
R4259 T6594 T6595 mark that,result
R4260 T6595 T6592 ccomp result,is
R4261 T6596 T6597 det these,alterations
R4262 T6597 T6595 nsubj alterations,result
R4263 T6598 T6597 prep in,alterations
R4264 T6599 T6600 compound alphaA,BKO
R4265 T6600 T6602 compound BKO,lenses
R4266 T6601 T6600 punct /,BKO
R4267 T6602 T6598 pobj lenses,in
R4268 T6603 T6602 compound mouse,lenses
R4269 T6604 T6595 prep from,result
R4270 T6605 T6606 amod increased,susceptibility
R4271 T6606 T6604 pobj susceptibility,from
R4272 T6607 T6606 prep of,susceptibility
R4273 T6608 T6609 det these,lenses
R4274 T6609 T6607 pobj lenses,of
R4275 T6610 T6606 prep to,susceptibility
R4276 T6611 T6612 npadvmod light,induced
R4277 T6612 T6614 amod induced,damage
R4278 T6613 T6612 punct -,induced
R4279 T6614 T6610 pobj damage,to
R4280 T6615 T6606 prep in,susceptibility
R4281 T6616 T6617 det the,absence
R4282 T6617 T6615 pobj absence,in
R4283 T6618 T6617 prep of,absence
R4284 T6619 T6620 det the,protection
R4285 T6620 T6618 pobj protection,of
R4286 T6621 T6620 amod molecular,protection
R4287 T6622 T6620 compound chaperone,protection
R4288 T6623 T6620 acl afforded,protection
R4289 T6624 T6623 agent by,afforded
R4290 T6625 T6624 pobj alphaA,by
R4291 T6626 T6625 cc and,alphaA
R4292 T6627 T6625 conj alphaB,alphaA
R4293 T6628 T6623 prep in,afforded
R4294 T6629 T6630 amod normal,lenses
R4295 T6630 T6628 pobj lenses,in
R4296 T6631 T6592 punct .,is
R4297 T6633 T6634 prep With,had
R4298 T6635 T6636 det the,time
R4299 T6636 T6633 pobj time,With
R4300 T6637 T6636 amod normal,time
R4301 T6638 T6636 prep of,time
R4302 T6639 T6640 compound eye,opening
R4303 T6640 T6638 pobj opening,of
R4304 T6641 T6636 prep at,time
R4305 T6642 T6643 advmod approximately,14
R4306 T6643 T6644 nummod 14,days
R4307 T6644 T6641 pobj days,at
R4308 T6645 T6644 prep after,days
R4309 T6646 T6645 pobj birth,after
R4310 T6647 T6634 punct ", ",had
R4311 T6648 T6649 det the,mice
R4312 T6649 T6634 nsubj mice,had
R4313 T6650 T6651 nummod 5,wk
R4314 T6651 T6652 npadvmod wk,old
R4315 T6652 T6649 amod old,mice
R4316 T6653 T6654 poss their,eyes
R4317 T6654 T6655 nsubj eyes,open
R4318 T6655 T6634 ccomp open,had
R4319 T6656 T6655 cc and,open
R4320 T6657 T6658 nsubj lenses,exposed
R4321 T6658 T6655 conj exposed,open
R4322 T6659 T6658 prep to,exposed
R4323 T6660 T6659 pobj light,to
R4324 T6661 T6655 prep for,open
R4325 T6662 T6663 advmod only,3
R4326 T6663 T6665 nummod 3,weeks
R4327 T6664 T6663 advmod about,3
R4328 T6665 T6661 pobj weeks,for
R4329 T6666 T6655 advmod prior,open
R4330 T6667 T6666 prep to,prior
R4331 T6668 T6669 amod morphological,analysis
R4332 T6669 T6667 pobj analysis,to
R4333 T6670 T6634 punct .,had
R4334 T6672 T6673 advmod Moreover,exposed
R4335 T6674 T6673 punct ", ",exposed
R4336 T6675 T6676 det these,animals
R4337 T6676 T6673 nsubjpass animals,exposed
R4338 T6677 T6673 aux had,exposed
R4339 T6678 T6673 auxpass been,exposed
R4340 T6679 T6673 prep to,exposed
R4341 T6680 T6681 advmod only,lighting
R4342 T6681 T6679 pobj lighting,to
R4343 T6682 T6683 amod animal,facility
R4344 T6683 T6681 nmod facility,lighting
R4345 T6684 T6681 amod fluorescent,lighting
R4346 T6685 T6686 cc and,protected
R4347 T6686 T6673 dep protected,exposed
R4348 T6687 T6686 auxpass were,protected
R4349 T6688 T6686 prep from,protected
R4350 T6689 T6690 compound UV,light
R4351 T6690 T6688 pobj light,from
R4352 T6691 T6686 prep by,protected
R4353 T6692 T6693 amod plastic,cages
R4354 T6693 T6691 pobj cages,by
R4355 T6694 T6673 punct .,exposed
R4356 T6696 T6697 mark If,was
R4357 T6697 T6706 advcl was,resided
R4358 T6698 T6697 nsubj lack,was
R4359 T6699 T6698 prep of,lack
R4360 T6700 T6699 pobj protection,of
R4361 T6701 T6700 prep from,protection
R4362 T6702 T6703 npadvmod light,induced
R4363 T6703 T6705 amod induced,damage
R4364 T6704 T6703 punct -,induced
R4365 T6705 T6701 pobj damage,from
R4366 T6707 T6708 det the,factor
R4367 T6708 T6697 attr factor,was
R4368 T6709 T6708 amod major,factor
R4369 T6710 T6708 acl affecting,factor
R4370 T6711 T6712 det the,changes
R4371 T6712 T6710 dobj changes,affecting
R4372 T6713 T6710 prep in,affecting
R4373 T6714 T6715 det these,lenses
R4374 T6715 T6713 pobj lenses,in
R4375 T6716 T6706 punct ", ",resided
R4376 T6717 T6706 advmod then,resided
R4377 T6718 T6719 det the,bulk
R4378 T6719 T6706 nsubj bulk,resided
R4379 T6720 T6719 prep of,bulk
R4380 T6721 T6722 det the,damage
R4381 T6722 T6720 pobj damage,of
R4382 T6723 T6706 aux should,resided
R4383 T6724 T6706 aux have,resided
R4384 T6725 T6706 prep along,resided
R4385 T6726 T6727 det the,axis
R4386 T6727 T6725 pobj axis,along
R4387 T6728 T6727 amod visual,axis
R4388 T6729 T6706 punct ", ",resided
R4389 T6730 T6731 advmod particularly,in
R4390 T6731 T6706 prep in,resided
R4391 T6732 T6733 det the,epithelium
R4392 T6733 T6731 pobj epithelium,in
R4393 T6734 T6733 amod central,epithelium
R4394 T6735 T6733 amod anterior,epithelium
R4395 T6736 T6733 cc and,epithelium
R4396 T6737 T6738 amod subcapsular,cortex
R4397 T6738 T6733 conj cortex,epithelium
R4398 T6739 T6706 prep in,resided
R4399 T6740 T6741 det the,lenses
R4400 T6741 T6739 pobj lenses,in
R4401 T6742 T6743 nummod 5,wk
R4402 T6743 T6741 npadvmod wk,lenses
R4403 T6744 T6706 punct ", ",resided
R4404 T6745 T6706 cc but,resided
R4405 T6746 T6747 nsubj this,was
R4406 T6747 T6706 conj was,resided
R4407 T6748 T6747 neg not,was
R4408 T6749 T6750 det the,case
R4409 T6750 T6747 attr case,was
R4410 T6751 T6747 punct .,was
R4411 T6753 T6754 prep In,were
R4412 T6755 T6756 det these,lenses
R4413 T6756 T6753 pobj lenses,In
R4414 T6757 T6754 punct ", ",were
R4415 T6758 T6759 amod gross,changes
R4416 T6759 T6754 nsubj changes,were
R4417 T6760 T6759 amod morphological,changes
R4418 T6761 T6754 acomp apparent,were
R4419 T6762 T6754 prep in,were
R4420 T6763 T6764 det the,regions
R4421 T6764 T6762 pobj regions,in
R4422 T6765 T6764 amod equatorial,regions
R4423 T6766 T6765 cc and,equatorial
R4424 T6767 T6765 conj posterior,equatorial
R4425 T6768 T6764 amod subcapsular,regions
R4426 T6769 T6754 punct .,were
R4427 T6771 T6772 det These,changes
R4428 T6772 T6773 nsubj changes,included
R4429 T6774 T6775 amod posterior,staining
R4430 T6775 T6773 dobj staining,included
R4431 T6776 T6775 amod subcapsular,staining
R4432 T6777 T6778 amod nucleic,acid
R4433 T6778 T6775 compound acid,staining
R4434 T6779 T6775 punct ", ",staining
R4435 T6780 T6775 conj absence,staining
R4436 T6781 T6780 prep of,absence
R4437 T6782 T6783 amod posterior,sutures
R4438 T6783 T6781 pobj sutures,of
R4439 T6784 T6780 punct ", ",absence
R4440 T6785 T6780 cc and,absence
R4441 T6786 T6787 amod small,cells
R4442 T6787 T6780 conj cells,absence
R4443 T6788 T6789 advmod irregularly,shaped
R4444 T6789 T6787 amod shaped,cells
R4445 T6790 T6787 punct ", ",cells
R4446 T6791 T6792 neg not,arranged
R4447 T6792 T6787 acl arranged,cells
R4448 T6793 T6792 prep in,arranged
R4449 T6794 T6795 det any,pattern
R4450 T6795 T6793 pobj pattern,in
R4451 T6796 T6795 amod discernable,pattern
R4452 T6797 T6792 punct ", ",arranged
R4453 T6798 T6792 prep in,arranged
R4454 T6799 T6800 det the,region
R4455 T6800 T6798 pobj region,in
R4456 T6801 T6802 amod equatorial,bow
R4457 T6802 T6800 amod bow,region
R4458 T6803 T6802 punct /,bow
R4459 T6804 T6773 punct .,included
R4460 T6806 T6807 amod Systemic,stress
R4461 T6807 T6808 compound stress,factors
R4462 T6808 T6809 nsubj factors,explain
R4463 T6810 T6808 acl crossing,factors
R4464 T6811 T6812 det the,barrier
R4465 T6812 T6810 dobj barrier,crossing
R4466 T6813 T6814 npadvmod blood,aqueous
R4467 T6814 T6812 amod aqueous,barrier
R4468 T6815 T6814 punct /,aqueous
R4469 T6816 T6809 aux might,explain
R4470 T6817 T6818 det some,changes
R4471 T6818 T6809 dobj changes,explain
R4472 T6819 T6818 amod morphological,changes
R4473 T6820 T6818 prep at,changes
R4474 T6821 T6822 det the,region
R4475 T6822 T6820 pobj region,at
R4476 T6823 T6822 amod equatorial,region
R4477 T6824 T6809 punct ", ",explain
R4478 T6825 T6809 cc but,explain
R4479 T6826 T6827 nsubj this,explain
R4480 T6827 T6809 conj explain,explain
R4481 T6828 T6827 aux would,explain
R4482 T6829 T6827 neg not,explain
R4483 T6830 T6831 amod nucleic,acid
R4484 T6831 T6832 compound acid,staining
R4485 T6832 T6827 dobj staining,explain
R4486 T6833 T6832 prep in,staining
R4487 T6834 T6835 det the,region
R4488 T6835 T6833 pobj region,in
R4489 T6836 T6835 amod posterior,region
R4490 T6837 T6835 amod subcapsular,region
R4491 T6838 T6827 punct .,explain
R4492 T6873 T6861 conj cells,cells
R4493 T6840 T6841 prep In,is
R4494 T6874 T6873 compound fiber,cells
R4495 T6875 T6873 acl failing,cells
R4496 T6842 T6843 det the,lenses
R4497 T6876 T6877 aux to,differentiate
R4498 T6877 T6875 xcomp differentiate,failing
R4499 T6878 T6877 advmod fully,differentiate
R4500 T6843 T6840 pobj lenses,In
R4501 T6879 T6877 prep by,differentiate
R4502 T6880 T6881 nummod 5,wks
R4503 T6881 T6879 pobj wks,by
R4504 T6844 T6845 nummod 5,wk
R4505 T6882 T6881 prep of,wks
R4506 T6883 T6882 pobj age,of
R4507 T6845 T6843 compound wk,lenses
R4508 T6884 T6841 punct .,is
R4509 T6886 T6887 det These,possibilities
R4510 T6846 T6847 compound alphaA,BKO
R4511 T6887 T6889 nsubjpass possibilities,differentiated
R4512 T6888 T6887 nummod two,possibilities
R4513 T6847 T6843 compound BKO,lenses
R4514 T6890 T6889 aux could,differentiated
R4515 T6891 T6889 neg not,differentiated
R4516 T6848 T6847 punct /,BKO
R4517 T6892 T6889 auxpass be,differentiated
R4518 T6893 T6889 prep in,differentiated
R4519 T6894 T6895 det the,methods
R4520 T6895 T6893 pobj methods,in
R4521 T6896 T6895 acl employed,methods
R4522 T6849 T6841 punct ", ",is
R4523 T6897 T6889 punct ", ",differentiated
R4524 T6898 T6889 cc and,differentiated
R4525 T6899 T6889 conj were,differentiated
R4526 T6900 T6899 prep beyond,were
R4527 T6850 T6851 amod nucleic,acid
R4528 T6901 T6902 det the,objectives
R4529 T6902 T6900 pobj objectives,beyond
R4530 T6851 T6852 compound acid,staining
R4531 T6903 T6902 prep of,objectives
R4532 T6904 T6905 det the,study
R4533 T6852 T6841 nsubj staining,is
R4534 T6905 T6903 pobj study,of
R4535 T6906 T6905 amod current,study
R4536 T6907 T6889 punct .,differentiated
R4537 T6909 T6910 amod Future,studies
R4538 T6853 T6852 prep in,staining
R4539 T6910 T6911 nsubjpass studies,designed
R4540 T6854 T6855 det the,region
R4541 T6912 T6911 aux are,designed
R4542 T6913 T6911 auxpass being,designed
R4543 T6914 T6915 aux to,address
R4544 T6855 T6853 pobj region,in
R4545 T6915 T6911 advcl address,designed
R4546 T6916 T6917 dep which,explain
R4547 T6856 T6855 amod posterior,region
R4548 T6857 T6855 amod subcapsular,region
R4549 T6917 T6915 ccomp explain,address
R4550 T6918 T6916 prep of,which
R4551 T6858 T6841 acomp consistent,is
R4552 T6919 T6920 det these,processes
R4553 T6920 T6918 pobj processes,of
R4554 T6921 T6920 nummod two,processes
R4555 T6859 T6858 prep with,consistent
R4556 T6922 T6917 aux might,explain
R4557 T6923 T6924 amod nucleic,acid
R4558 T6860 T6861 preconj either,cells
R4559 T6924 T6925 compound acid,staining
R4560 T6925 T6917 dobj staining,explain
R4561 T6926 T6925 prep in,staining
R4562 T6861 T6859 pobj cells,with
R4563 T6927 T6928 det the,region
R4564 T6928 T6926 pobj region,in
R4565 T6862 T6861 amod anterior,cells
R4566 T6929 T6928 amod posterior,region
R4567 T6930 T6928 amod subcapsular,region
R4568 T6931 T6911 punct .,designed
R4569 T6863 T6861 amod epithelial,cells
R4570 T6933 T6934 nsubjpass Staining,observed
R4571 T6864 T6861 acl migrating,cells
R4572 T6935 T6933 prep in,Staining
R4573 T6936 T6937 det this,region
R4574 T6937 T6935 pobj region,in
R4575 T6938 T6934 auxpass was,observed
R4576 T6865 T6864 advmod aberrantly,migrating
R4577 T6939 T6934 neg not,observed
R4578 T6940 T6934 prep in,observed
R4579 T6941 T6942 amod older,lenses
R4580 T6866 T6864 prep to,migrating
R4581 T6942 T6940 pobj lenses,in
R4582 T6943 T6944 compound alphaA,BKO
R4583 T6944 T6942 compound BKO,lenses
R4584 T6867 T6868 det the,pole
R4585 T6945 T6944 punct /,BKO
R4586 T6946 T6934 punct ", ",observed
R4587 T6947 T6934 advcl suggesting,observed
R4588 T6868 T6866 pobj pole,to
R4589 T6948 T6949 mark that,was
R4590 T6949 T6947 ccomp was,suggesting
R4591 T6869 T6868 amod posterior,pole
R4592 T6950 T6951 det this,pattern
R4593 T6951 T6949 nsubj pattern,was
R4594 T6952 T6949 acomp transient,was
R4595 T6870 T6861 punct ", ",cells
R4596 T6953 T6934 punct .,observed
R4597 T6955 T6956 det The,fate
R4598 T6871 T6861 cc or,cells
R4599 T6956 T6957 nsubjpass fate,known
R4600 T6958 T6956 prep of,fate
R4601 T6872 T6873 amod primary,cells
R4602 T6959 T6960 det the,cells
R4603 T6960 T6958 pobj cells,of
R4604 T6961 T6962 amod nucleic,acid
R4605 T6979 T6957 cc nor,known
R4606 T6962 T6963 npadvmod acid,containing
R4607 T6963 T6960 amod containing,cells
R4608 T6980 T6957 conj is,known
R4609 T6964 T6963 punct -,containing
R4610 T6965 T6960 prep in,cells
R4611 T6966 T6967 det the,region
R4612 T6981 T6982 det the,morphology
R4613 T6967 T6965 pobj region,in
R4614 T6968 T6967 amod posterior,region
R4615 T6969 T6967 amod capsular,region
R4616 T6982 T6980 nsubj morphology,is
R4617 T6970 T6967 prep of,region
R4618 T6971 T6972 amod younger,lenses
R4619 T6972 T6970 pobj lenses,of
R4620 T6983 T6982 prep of,morphology
R4621 T6973 T6957 auxpass is,known
R4622 T6974 T6957 neg not,known
R4623 T6975 T6957 prep at,known
R4624 T6976 T6977 det this,time
R4625 T6977 T6975 pobj time,at
R4626 T6978 T6957 punct ", ",known
R4627 T6984 T6985 amod earlier,stage
R4628 T6985 T6986 compound stage,lenses
R4629 T6986 T6983 pobj lenses,of
R4630 T6987 T6980 punct .,is
R4632 T6989 T6990 amod Future,studies
R4637 T6990 T6991 nsubjpass studies,designed
R4641 T6992 T6990 prep with,studies
R4642 T6993 T6994 amod defined,objectives
R4646 T6994 T6992 pobj objectives,with
R4649 T6995 T6996 aux to,address
R4653 T6996 T6994 acl address,objectives
R4656 T6997 T6998 det the,development
R4659 T6998 T6996 dobj development,address
R4662 T6999 T6998 cc and,development
R4666 T7000 T6998 conj progression,development
R4668 T7001 T6998 prep of,development
R4673 T7002 T7003 amod morphological,changes
R4679 T7003 T7001 pobj changes,of
R4684 T7004 T7003 acl seen,changes
R4688 T7005 T7004 prep in,seen
R4691 T7006 T7007 det this,study
R4697 T7007 T7005 pobj study,in
R4700 T7008 T6991 aux are,designed
R4704 T7009 T6991 auxpass being,designed
R4706 T7010 T6991 punct .,designed
R4708 T7012 T7013 det The,differences
R4712 T7013 T7015 nsubj differences,were
R4716 T7014 T7013 amod morphological,differences
R4720 T7016 T7013 prep in,differences
R4725 T7017 T7018 compound alphaA,BKO
R4731 T7018 T7020 compound BKO,lenses
R4736 T7019 T7018 punct /,BKO
R4740 T7020 T7016 pobj lenses,in
R4744 T7021 T7013 punct ", ",differences
R4747 T7022 T7013 prep compared,differences
R4751 T7023 T7022 prep to,compared
R4752 T7024 T7025 npadvmod age,matched
R4755 T7025 T7026 amod matched,lenses
R4759 T7026 T7023 pobj lenses,to
R4762 T7027 T7028 amod wild,type
R4766 T7028 T7026 compound type,lenses
R4769 T7029 T7015 punct ", ",were
R4770 T7030 T7015 acomp consistent,were
R4771 T7031 T7030 prep with,consistent
R4773 T7032 T7033 det the,hypothesis
R4777 T7033 T7031 pobj hypothesis,with
R4783 T7034 T7035 mark that,plays
R4786 T7035 T7033 acl plays,hypothesis
R4789 T7036 T7037 compound alpha,crystallin
R4793 T7037 T7035 nsubj crystallin,plays
R4796 T7038 T7037 punct -,crystallin
R4800 T7039 T7040 det an,role
R4803 T7040 T7035 dobj role,plays
R4807 T7041 T7040 amod active,role
R4810 T7042 T7035 prep in,plays
R4814 T7043 T7044 det the,differentiation
R4818 T7044 T7042 pobj differentiation,in
R4822 T7045 T7044 cc and,differentiation
R4826 T7046 T7044 conj growth,differentiation
R4830 T7047 T7044 prep of,differentiation
R4833 T7048 T7049 compound lens,fiber
R4838 T7049 T7050 compound fiber,cells
R4843 T7050 T7047 pobj cells,of
R4846 T7051 T7015 punct .,were
R4849 T7053 T7054 prep In,was
R4853 T7055 T7053 pobj addition,In
R4858 T7056 T7054 punct ", ",was
R4861 T7057 T7054 nsubj it,was
R4865 T7058 T7059 advmod clearly,evident
R4866 T7059 T7054 acomp evident,was
R4869 T7060 T7061 mark that,is
R4873 T7061 T7054 ccomp is,was
R4877 T7062 T7063 compound alpha,crystallin
R4880 T7063 T7061 nsubj crystallin,is
R4884 T7064 T7063 punct -,crystallin
R4890 T7065 T7061 acomp necessary,is
R4895 T7066 T7065 prep for,necessary
R4898 T7067 T7068 compound lens,transparency
R4901 T7068 T7066 pobj transparency,for
R4904 T7069 T7054 punct .,was