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PMC:149350 / 105-1649 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T153 0-10 sentence denotes Background
T154 0-10 NN denotes Background
T155 10-193 sentence denotes One approach to resolving some of the in vivo functions of alpha-crystallin is to generate animal models where one or both of the alpha-crystallin gene products have been eliminated.
T156 11-14 CD denotes One
T157 15-23 NN denotes approach
T159 24-26 IN denotes to
T160 27-36 VBG denotes resolving
T161 37-41 DT denotes some
T162 42-44 IN denotes of
T163 45-48 DT denotes the
T165 49-51 FW denotes in
T166 52-56 FW denotes vivo
T164 57-66 NNS denotes functions
T167 67-69 IN denotes of
T168 70-75 NN denotes alpha
T170 75-76 HYPH denotes -
T169 76-86 NN denotes crystallin
T158 87-89 VBZ denotes is
T171 90-92 TO denotes to
T172 93-101 VB denotes generate
T173 102-108 NN denotes animal
T174 109-115 NNS denotes models
T175 116-121 WRB denotes where
T177 122-125 CD denotes one
T178 126-128 CC denotes or
T179 129-133 DT denotes both
T180 134-136 IN denotes of
T181 137-140 DT denotes the
T183 141-146 NN denotes alpha
T185 146-147 HYPH denotes -
T184 147-157 NN denotes crystallin
T186 158-162 NN denotes gene
T182 163-171 NNS denotes products
T187 172-176 VBP denotes have
T188 177-181 VBN denotes been
T176 182-192 VBN denotes eliminated
T189 192-193 . denotes .
T190 193-446 sentence denotes In the single alpha-crystallin knockout mice, the remaining alpha-crystallin may fully or partially compensate for some of the functions of the missing protein, especially in the lens, where both alphaA and alphaB are normally expressed at high levels.
T191 194-196 IN denotes In
T193 197-200 DT denotes the
T195 201-207 JJ denotes single
T197 208-213 NN denotes alpha
T199 213-214 HYPH denotes -
T198 214-224 NN denotes crystallin
T196 225-233 NN denotes knockout
T194 234-238 NNS denotes mice
T200 238-240 , denotes ,
T201 240-243 DT denotes the
T203 244-253 VBG denotes remaining
T204 254-259 NN denotes alpha
T205 259-260 HYPH denotes -
T202 260-270 NN denotes crystallin
T206 271-274 MD denotes may
T207 275-280 RB denotes fully
T208 281-283 CC denotes or
T209 284-293 RB denotes partially
T192 294-304 VB denotes compensate
T210 305-308 IN denotes for
T211 309-313 DT denotes some
T212 314-316 IN denotes of
T213 317-320 DT denotes the
T214 321-330 NNS denotes functions
T215 331-333 IN denotes of
T216 334-337 DT denotes the
T218 338-345 VBG denotes missing
T217 346-353 NN denotes protein
T219 353-355 , denotes ,
T220 355-365 RB denotes especially
T221 366-368 IN denotes in
T222 369-372 DT denotes the
T223 373-377 NN denotes lens
T224 377-379 , denotes ,
T225 379-384 WRB denotes where
T227 385-389 CC denotes both
T228 390-396 NN denotes alphaA
T229 397-400 CC denotes and
T230 401-407 NN denotes alphaB
T231 408-411 VBP denotes are
T232 412-420 RB denotes normally
T226 421-430 VBN denotes expressed
T233 431-433 IN denotes at
T234 434-438 JJ denotes high
T235 439-445 NNS denotes levels
T236 445-446 . denotes .
T237 446-626 sentence denotes The purpose of this study was to characterize gross lenticular morphology in normal mice and mice with the targeted disruption of alphaA- and alphaB-crystallin genes (alphaA/BKO).
T238 447-450 DT denotes The
T239 451-458 NN denotes purpose
T241 459-461 IN denotes of
T242 462-466 DT denotes this
T243 467-472 NN denotes study
T240 473-476 VBD denotes was
T244 477-479 TO denotes to
T245 480-492 VB denotes characterize
T246 493-498 JJ denotes gross
T248 499-509 JJ denotes lenticular
T247 510-520 NN denotes morphology
T249 521-523 IN denotes in
T250 524-530 JJ denotes normal
T251 531-535 NNS denotes mice
T252 536-539 CC denotes and
T253 540-544 NNS denotes mice
T254 545-549 IN denotes with
T255 550-553 DT denotes the
T257 554-562 VBN denotes targeted
T256 563-573 NN denotes disruption
T258 574-576 IN denotes of
T259 577-583 NN denotes alphaA
T261 583-584 HYPH denotes -
T262 585-588 CC denotes and
T263 589-595 NN denotes alphaB
T264 595-596 HYPH denotes -
T260 596-606 NN denotes crystallin
T265 607-612 NNS denotes genes
T266 613-614 -LRB- denotes (
T267 614-620 NN denotes alphaA
T269 620-621 HYPH denotes /
T268 621-624 NN denotes BKO
T270 624-625 -RRB- denotes )
T271 625-626 . denotes .
T272 626-635 sentence denotes Methods
T273 628-635 NNS denotes Methods
T274 635-777 sentence denotes Lenses from 129SvEvTac mice and alphaA/BKO mice were examined by standard scanning electron microscopy and confocal microscopy methodologies.
T275 636-642 NNS denotes Lenses
T277 643-647 IN denotes from
T278 648-658 NN denotes 129SvEvTac
T279 659-663 NNS denotes mice
T280 664-667 CC denotes and
T281 668-674 NN denotes alphaA
T283 674-675 HYPH denotes /
T282 675-678 NN denotes BKO
T284 679-683 NNS denotes mice
T285 684-688 VBD denotes were
T276 689-697 VBN denotes examined
T286 698-700 IN denotes by
T287 701-709 JJ denotes standard
T289 710-718 NN denotes scanning
T290 719-727 NN denotes electron
T288 728-738 NN denotes microscopy
T292 739-742 CC denotes and
T293 743-751 JJ denotes confocal
T294 752-762 NN denotes microscopy
T291 763-776 NNS denotes methodologies
T295 776-777 . denotes .
T296 777-786 sentence denotes Results
T297 779-786 NNS denotes Results
T298 786-921 sentence denotes Equatorial and axial (sagittal) dimensions of lenses for alphaA/BKO mice were significantly smaller than age-matched wild type lenses.
T299 787-797 JJ denotes Equatorial
T3289 787-797 JJ denotes Equatorial
T301 798-801 CC denotes and
T3291 798-801 CC denotes and
T302 802-807 JJ denotes axial
T3292 802-807 JJ denotes axial
T304 808-809 -LRB- denotes (
T3294 808-809 -LRB- denotes (
T303 809-817 JJ denotes sagittal
T3293 809-817 JJ denotes sagittal
T305 817-818 -RRB- denotes )
T3295 817-818 -RRB- denotes )
T300 819-829 NNS denotes dimensions
T3290 819-829 NNS denotes dimensions
T307 830-832 IN denotes of
T3297 830-832 IN denotes of
T308 833-839 NNS denotes lenses
T3298 833-839 NNS denotes lenses
T309 840-843 IN denotes for
T310 844-850 NN denotes alphaA
T312 850-851 HYPH denotes /
T311 851-854 NN denotes BKO
T313 855-859 NNS denotes mice
T306 860-864 VBD denotes were
T314 865-878 RB denotes significantly
T315 879-886 JJR denotes smaller
T316 887-891 IN denotes than
T317 892-895 NN denotes age
T319 895-896 HYPH denotes -
T318 896-903 VBN denotes matched
T321 904-908 JJ denotes wild
T322 909-913 NN denotes type
T320 914-920 NNS denotes lenses
T323 920-921 . denotes .
T324 921-1037 sentence denotes No posterior sutures or fiber cells extending to the posterior capsule of the lens were found in alphaA/BKO lenses.
T325 922-924 DT denotes No
T327 925-934 JJ denotes posterior
T326 935-942 NNS denotes sutures
T329 943-945 CC denotes or
T330 946-951 NN denotes fiber
T331 952-957 NNS denotes cells
T332 958-967 VBG denotes extending
T333 968-970 IN denotes to
T334 971-974 DT denotes the
T336 975-984 JJ denotes posterior
T335 985-992 NN denotes capsule
T337 993-995 IN denotes of
T338 996-999 DT denotes the
T339 1000-1004 NN denotes lens
T340 1005-1009 VBD denotes were
T328 1010-1015 VBN denotes found
T341 1016-1018 IN denotes in
T342 1019-1025 NN denotes alphaA
T344 1025-1026 HYPH denotes /
T343 1026-1029 NN denotes BKO
T345 1030-1036 NNS denotes lenses
T346 1036-1037 . denotes .
T347 1037-1186 sentence denotes Ectopical nucleic acid staining was observed in the posterior subcapsular region of 5 wk and anterior subcapsular cortex of 54 wk alphaA/BKO lenses.
T348 1038-1047 JJ denotes Ectopical
T350 1048-1055 JJ denotes nucleic
T351 1056-1060 NN denotes acid
T349 1061-1069 NN denotes staining
T353 1070-1073 VBD denotes was
T352 1074-1082 VBN denotes observed
T354 1083-1085 IN denotes in
T355 1086-1089 DT denotes the
T357 1090-1099 JJ denotes posterior
T358 1100-1111 JJ denotes subcapsular
T356 1112-1118 NN denotes region
T359 1119-1121 IN denotes of
T360 1122-1123 CD denotes 5
T361 1124-1126 NN denotes wk
T362 1127-1130 CC denotes and
T363 1131-1139 JJ denotes anterior
T365 1140-1151 JJ denotes subcapsular
T364 1152-1158 NN denotes cortex
T367 1159-1161 IN denotes of
T368 1162-1164 CD denotes 54
T369 1165-1167 NN denotes wk
T370 1168-1174 NN denotes alphaA
T372 1174-1175 HYPH denotes /
T371 1175-1178 NN denotes BKO
T366 1179-1185 NNS denotes lenses
T373 1185-1186 . denotes .
T374 1186-1348 sentence denotes Gross morphological differences were also observed in the equatorial/bow, posterior and anterior regions of lenses from alphaA/BKO mice as compared to wild mice.
T375 1187-1192 JJ denotes Gross
T377 1193-1206 JJ denotes morphological
T376 1207-1218 NNS denotes differences
T379 1219-1223 VBD denotes were
T380 1224-1228 RB denotes also
T378 1229-1237 VBN denotes observed
T381 1238-1240 IN denotes in
T382 1241-1244 DT denotes the
T384 1245-1255 JJ denotes equatorial
T386 1255-1256 HYPH denotes /
T385 1256-1259 JJ denotes bow
T387 1259-1261 , denotes ,
T388 1261-1270 JJ denotes posterior
T389 1271-1274 CC denotes and
T390 1275-1283 JJ denotes anterior
T383 1284-1291 NNS denotes regions
T391 1292-1294 IN denotes of
T392 1295-1301 NNS denotes lenses
T393 1302-1306 IN denotes from
T394 1307-1313 NN denotes alphaA
T396 1313-1314 HYPH denotes /
T395 1314-1317 NN denotes BKO
T397 1318-1322 NNS denotes mice
T398 1323-1325 IN denotes as
T399 1326-1334 VBN denotes compared
T400 1335-1337 IN denotes to
T401 1338-1342 JJ denotes wild
T402 1343-1347 NNS denotes mice
T403 1347-1348 . denotes .
T404 1348-1360 sentence denotes Conclusion
T405 1350-1360 NN denotes Conclusion
T406 1360-1544 sentence denotes These results indicated that both alphaA- and alphaB-crystallin are necessary for proper fiber cell formation, and that the absence of alpha-crystallin can lead to cataract formation.
T407 1361-1366 DT denotes These
T408 1367-1374 NNS denotes results
T409 1375-1384 VBD denotes indicated
T410 1385-1389 IN denotes that
T412 1390-1394 CC denotes both
T413 1395-1401 NN denotes alphaA
T415 1401-1402 HYPH denotes -
T416 1403-1406 CC denotes and
T417 1407-1413 NN denotes alphaB
T418 1413-1414 HYPH denotes -
T414 1414-1424 NN denotes crystallin
T411 1425-1428 VBP denotes are
T419 1429-1438 JJ denotes necessary
T420 1439-1442 IN denotes for
T421 1443-1449 JJ denotes proper
T423 1450-1455 NN denotes fiber
T424 1456-1460 NN denotes cell
T422 1461-1470 NN denotes formation
T425 1470-1472 , denotes ,
T426 1472-1475 CC denotes and
T427 1476-1480 IN denotes that
T429 1481-1484 DT denotes the
T430 1485-1492 NN denotes absence
T431 1493-1495 IN denotes of
T432 1496-1501 NN denotes alpha
T434 1501-1502 HYPH denotes -
T433 1502-1512 NN denotes crystallin
T435 1513-1516 MD denotes can
T428 1517-1521 VB denotes lead
T436 1522-1524 IN denotes to
T437 1525-1533 NN denotes cataract
T438 1534-1543 NN denotes formation
T439 1543-1544 . denotes .
R100 T241 T239 prep of,purpose
R101 T242 T243 det this,study
R102 T243 T241 pobj study,of
R103 T244 T245 aux to,characterize
R104 T245 T240 xcomp characterize,was
R105 T246 T247 amod gross,morphology
R106 T247 T245 dobj morphology,characterize
R107 T248 T247 amod lenticular,morphology
R108 T249 T245 prep in,characterize
R109 T250 T251 amod normal,mice
R110 T251 T249 pobj mice,in
R111 T252 T251 cc and,mice
R112 T253 T251 conj mice,mice
R113 T254 T253 prep with,mice
R114 T255 T256 det the,disruption
R115 T256 T254 pobj disruption,with
R116 T257 T256 amod targeted,disruption
R117 T258 T256 prep of,disruption
R118 T259 T260 nmod alphaA,crystallin
R119 T260 T265 compound crystallin,genes
R120 T261 T259 punct -,alphaA
R121 T262 T259 cc and,alphaA
R122 T263 T259 conj alphaB,alphaA
R123 T264 T260 punct -,crystallin
R124 T265 T258 pobj genes,of
R125 T266 T265 punct (,genes
R126 T267 T268 compound alphaA,BKO
R127 T268 T265 parataxis BKO,genes
R128 T269 T268 punct /,BKO
R129 T270 T268 punct ),BKO
R130 T271 T240 punct .,was
R131 T275 T276 nsubjpass Lenses,examined
R132 T277 T275 prep from,Lenses
R133 T278 T279 compound 129SvEvTac,mice
R134 T279 T277 pobj mice,from
R135 T280 T279 cc and,mice
R136 T281 T282 compound alphaA,BKO
R137 T282 T284 compound BKO,mice
R138 T283 T282 punct /,BKO
R139 T284 T279 conj mice,mice
R140 T285 T276 auxpass were,examined
R141 T286 T276 prep by,examined
R142 T287 T288 amod standard,microscopy
R143 T288 T291 nmod microscopy,methodologies
R144 T289 T288 nmod scanning,microscopy
R145 T290 T288 nmod electron,microscopy
R146 T291 T286 pobj methodologies,by
R147 T292 T288 cc and,microscopy
R148 T293 T294 amod confocal,microscopy
R149 T294 T288 conj microscopy,microscopy
R150 T295 T276 punct .,examined
R151 T299 T300 amod Equatorial,dimensions
R152 T300 T306 nsubj dimensions,were
R153 T301 T299 cc and,Equatorial
R154 T302 T303 amod axial,sagittal
R155 T303 T299 conj sagittal,Equatorial
R156 T304 T303 punct (,sagittal
R157 T305 T303 punct ),sagittal
R158 T307 T300 prep of,dimensions
R159 T308 T307 pobj lenses,of
R160 T309 T308 prep for,lenses
R161 T310 T311 compound alphaA,BKO
R162 T311 T313 compound BKO,mice
R163 T312 T311 punct /,BKO
R164 T313 T309 pobj mice,for
R165 T314 T315 advmod significantly,smaller
R166 T315 T306 acomp smaller,were
R167 T316 T315 prep than,smaller
R168 T317 T318 npadvmod age,matched
R169 T318 T320 amod matched,lenses
R170 T319 T318 punct -,matched
R171 T320 T316 pobj lenses,than
R172 T321 T322 amod wild,type
R173 T322 T320 compound type,lenses
R174 T323 T306 punct .,were
R175 T325 T326 det No,sutures
R176 T326 T328 nsubjpass sutures,found
R177 T327 T326 amod posterior,sutures
R178 T329 T326 cc or,sutures
R179 T330 T331 compound fiber,cells
R180 T331 T326 conj cells,sutures
R181 T332 T326 acl extending,sutures
R182 T333 T332 prep to,extending
R183 T334 T335 det the,capsule
R184 T335 T333 pobj capsule,to
R185 T336 T335 amod posterior,capsule
R186 T337 T335 prep of,capsule
R187 T338 T339 det the,lens
R188 T339 T337 pobj lens,of
R189 T340 T328 auxpass were,found
R190 T341 T328 prep in,found
R191 T342 T343 compound alphaA,BKO
R192 T343 T345 compound BKO,lenses
R193 T344 T343 punct /,BKO
R194 T345 T341 pobj lenses,in
R195 T346 T328 punct .,found
R196 T348 T349 amod Ectopical,staining
R197 T349 T352 nsubjpass staining,observed
R1977 T3289 T3290 amod Equatorial,dimensions
R1979 T3291 T3289 cc and,Equatorial
R198 T350 T351 amod nucleic,acid
R1980 T3292 T3293 amod axial,sagittal
R1981 T3293 T3289 conj sagittal,Equatorial
R1982 T3294 T3293 punct (,sagittal
R1983 T3295 T3290 punct ),dimensions
R1984 T3297 T3290 prep of,dimensions
R1985 T3298 T3297 pobj lenses,of
R199 T351 T349 compound acid,staining
R20 T156 T157 nummod One,approach
R200 T353 T352 auxpass was,observed
R201 T354 T352 prep in,observed
R202 T355 T356 det the,region
R203 T356 T354 pobj region,in
R204 T357 T356 amod posterior,region
R205 T358 T356 amod subcapsular,region
R206 T359 T356 prep of,region
R207 T360 T361 nummod 5,wk
R208 T361 T359 pobj wk,of
R209 T362 T356 cc and,region
R21 T157 T158 nsubj approach,is
R210 T363 T364 amod anterior,cortex
R211 T364 T366 nmod cortex,lenses
R212 T365 T364 amod subcapsular,cortex
R213 T366 T356 conj lenses,region
R214 T367 T364 prep of,cortex
R215 T368 T369 nummod 54,wk
R216 T369 T367 pobj wk,of
R217 T370 T371 compound alphaA,BKO
R218 T371 T366 compound BKO,lenses
R219 T372 T371 punct /,BKO
R22 T159 T157 prep to,approach
R220 T373 T352 punct .,observed
R221 T375 T376 amod Gross,differences
R222 T376 T378 nsubjpass differences,observed
R223 T377 T376 amod morphological,differences
R224 T379 T378 auxpass were,observed
R225 T380 T378 advmod also,observed
R226 T381 T378 prep in,observed
R227 T382 T383 det the,regions
R228 T383 T381 pobj regions,in
R229 T384 T385 amod equatorial,bow
R23 T160 T159 pcomp resolving,to
R230 T385 T383 amod bow,regions
R231 T386 T385 punct /,bow
R232 T387 T385 punct ", ",bow
R233 T388 T385 conj posterior,bow
R234 T389 T388 cc and,posterior
R235 T390 T388 conj anterior,posterior
R236 T391 T383 prep of,regions
R237 T392 T391 pobj lenses,of
R238 T393 T392 prep from,lenses
R239 T394 T395 compound alphaA,BKO
R24 T161 T160 dobj some,resolving
R240 T395 T397 compound BKO,mice
R241 T396 T395 punct /,BKO
R242 T397 T393 pobj mice,from
R243 T398 T399 mark as,compared
R244 T399 T383 advcl compared,regions
R245 T400 T399 prep to,compared
R246 T401 T402 amod wild,mice
R247 T402 T400 pobj mice,to
R248 T403 T378 punct .,observed
R249 T407 T408 det These,results
R25 T162 T161 prep of,some
R250 T408 T409 nsubj results,indicated
R251 T410 T411 mark that,are
R252 T411 T409 advcl are,indicated
R253 T412 T413 preconj both,alphaA
R254 T413 T414 nmod alphaA,crystallin
R255 T414 T411 nsubj crystallin,are
R256 T415 T413 punct -,alphaA
R257 T416 T413 cc and,alphaA
R258 T417 T413 conj alphaB,alphaA
R259 T418 T414 punct -,crystallin
R26 T163 T164 det the,functions
R260 T419 T411 acomp necessary,are
R261 T420 T419 prep for,necessary
R262 T421 T422 amod proper,formation
R263 T422 T420 pobj formation,for
R264 T423 T424 compound fiber,cell
R265 T424 T422 compound cell,formation
R266 T425 T411 punct ", ",are
R267 T426 T411 cc and,are
R268 T427 T428 mark that,lead
R269 T428 T411 conj lead,are
R27 T164 T162 pobj functions,of
R270 T429 T430 det the,absence
R271 T430 T428 nsubj absence,lead
R272 T431 T430 prep of,absence
R273 T432 T433 compound alpha,crystallin
R274 T433 T431 pobj crystallin,of
R275 T434 T433 punct -,crystallin
R276 T435 T428 aux can,lead
R277 T436 T428 prep to,lead
R278 T437 T438 compound cataract,formation
R279 T438 T436 pobj formation,to
R28 T165 T166 advmod in,vivo
R280 T439 T409 punct .,indicated
R29 T166 T164 amod vivo,functions
R30 T167 T164 prep of,functions
R31 T168 T169 compound alpha,crystallin
R32 T169 T167 pobj crystallin,of
R33 T170 T169 punct -,crystallin
R34 T171 T172 aux to,generate
R35 T172 T158 xcomp generate,is
R36 T173 T174 compound animal,models
R37 T174 T172 dobj models,generate
R38 T175 T176 advmod where,eliminated
R39 T176 T174 relcl eliminated,models
R40 T177 T176 nsubjpass one,eliminated
R41 T178 T177 cc or,one
R42 T179 T177 conj both,one
R43 T180 T177 prep of,one
R44 T181 T182 det the,products
R45 T182 T180 pobj products,of
R46 T183 T184 compound alpha,crystallin
R47 T184 T182 compound crystallin,products
R48 T185 T184 punct -,crystallin
R49 T186 T182 compound gene,products
R50 T187 T176 aux have,eliminated
R51 T188 T176 auxpass been,eliminated
R52 T189 T158 punct .,is
R53 T191 T192 prep In,compensate
R54 T193 T194 det the,mice
R55 T194 T191 pobj mice,In
R56 T195 T196 amod single,knockout
R57 T196 T194 compound knockout,mice
R58 T197 T198 compound alpha,crystallin
R59 T198 T196 compound crystallin,knockout
R60 T199 T198 punct -,crystallin
R61 T200 T192 punct ", ",compensate
R62 T201 T202 det the,crystallin
R63 T202 T192 nsubj crystallin,compensate
R64 T203 T202 amod remaining,crystallin
R65 T204 T202 compound alpha,crystallin
R66 T205 T202 punct -,crystallin
R67 T206 T192 aux may,compensate
R68 T207 T192 advmod fully,compensate
R69 T208 T207 cc or,fully
R70 T209 T207 conj partially,fully
R71 T210 T192 prep for,compensate
R72 T211 T210 pobj some,for
R73 T212 T211 prep of,some
R74 T213 T214 det the,functions
R75 T214 T212 pobj functions,of
R76 T215 T214 prep of,functions
R77 T216 T217 det the,protein
R78 T217 T215 pobj protein,of
R79 T218 T217 amod missing,protein
R80 T219 T192 punct ", ",compensate
R81 T220 T221 advmod especially,in
R82 T221 T192 prep in,compensate
R83 T222 T223 det the,lens
R84 T223 T221 pobj lens,in
R85 T224 T223 punct ", ",lens
R86 T225 T226 advmod where,expressed
R87 T226 T223 relcl expressed,lens
R88 T227 T228 preconj both,alphaA
R89 T228 T226 nsubjpass alphaA,expressed
R90 T229 T228 cc and,alphaA
R91 T230 T228 conj alphaB,alphaA
R92 T231 T226 auxpass are,expressed
R93 T232 T226 advmod normally,expressed
R94 T233 T226 prep at,expressed
R95 T234 T235 amod high,levels
R96 T235 T233 pobj levels,at
R97 T236 T192 punct .,compensate
R98 T238 T239 det The,purpose
R99 T239 T240 nsubj purpose,was