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PMC:1482699 / 32182-33322 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T19502 0-4 RBR denotes More
T19503 5-16 RB denotes importantly
T19505 16-18 , denotes ,
T19506 18-28 VBG denotes sequencing
T19507 29-31 NN denotes hg
T19508 32-40 NN denotes modifier
T19509 41-51 NNS denotes candidates
T19504 52-59 VBD denotes allowed
T19510 60-62 PRP denotes us
T19512 63-65 TO denotes to
T19511 66-74 VB denotes identify
T19513 75-88 JJ denotes nonsynonomous
T19514 89-101 NN denotes polymorphism
T19515 101-103 , denotes ,
T19516 103-108 WDT denotes which
T19518 109-112 MD denotes may
T19517 113-121 VB denotes underlie
T19519 122-125 NN denotes QTL
T19520 125-126 . denotes .
T19521 126-271 sentence denotes SIFT and/or PolyPhen predicted alterations in protein function for 15 of the 56 total nsSNP (27%) in nine of the 44 total genes (20%) (Table 7).
T19522 127-131 NNP denotes SIFT
T19524 132-135 CC denotes and
T19525 135-136 HYPH denotes /
T19526 136-138 CC denotes or
T19527 139-147 NNP denotes PolyPhen
T19523 148-157 VBN denotes predicted
T19528 158-169 NNS denotes alterations
T19529 170-172 IN denotes in
T19530 173-180 NN denotes protein
T19531 181-189 NN denotes function
T19532 190-193 IN denotes for
T19533 194-196 CD denotes 15
T19534 197-199 IN denotes of
T19535 200-203 DT denotes the
T19537 204-206 CD denotes 56
T19538 207-212 JJ denotes total
T19536 213-218 NN denotes nsSNP
T19539 219-220 -LRB- denotes (
T19541 220-222 CD denotes 27
T19540 222-223 NN denotes %
T19542 223-224 -RRB- denotes )
T19543 225-227 IN denotes in
T19544 228-232 CD denotes nine
T19545 233-235 IN denotes of
T19546 236-239 DT denotes the
T19548 240-242 CD denotes 44
T19549 243-248 JJ denotes total
T19547 249-254 NNS denotes genes
T19550 255-256 -LRB- denotes (
T19552 256-258 CD denotes 20
T19551 258-259 NN denotes %
T19553 259-260 -RRB- denotes )
T19554 261-262 -LRB- denotes (
T19555 262-267 NN denotes Table
T19556 268-269 CD denotes 7
T19557 269-270 -RRB- denotes )
T19558 270-271 . denotes .
T19559 271-413 sentence denotes It has been shown that predicting function based on evolutionary conservation using programs such as SIFT and PolyPhen is very accurate [49].
T19560 272-274 PRP denotes It
T19562 275-278 VBZ denotes has
T19563 279-283 VBN denotes been
T19561 284-289 VBN denotes shown
T19564 290-294 IN denotes that
T19566 295-305 VBG denotes predicting
T19567 306-314 NN denotes function
T19568 315-320 VBN denotes based
T19569 321-323 IN denotes on
T19570 324-336 JJ denotes evolutionary
T19571 337-349 NN denotes conservation
T19572 350-355 VBG denotes using
T19573 356-364 NNS denotes programs
T19574 365-369 JJ denotes such
T19575 370-372 IN denotes as
T19576 373-377 NNP denotes SIFT
T19577 378-381 CC denotes and
T19578 382-390 NNP denotes PolyPhen
T19565 391-393 VBZ denotes is
T19579 394-398 RB denotes very
T19580 399-407 JJ denotes accurate
T19581 408-409 -LRB- denotes [
T19582 409-411 CD denotes 49
T19583 411-412 -RRB- denotes ]
T19584 412-413 . denotes .
T19585 413-524 sentence denotes Four of the nine genes (Ubr1, Ptpns1, Ubce7ip5 and Mmp9; all of which are on MMU2) are of particular interest.
T19586 414-418 CD denotes Four
T19588 419-421 IN denotes of
T19589 422-425 DT denotes the
T19591 426-430 CD denotes nine
T19590 431-436 NNS denotes genes
T19592 437-438 -LRB- denotes (
T19593 438-442 NN denotes Ubr1
T19594 442-444 , denotes ,
T19595 444-450 NN denotes Ptpns1
T19596 450-452 , denotes ,
T19597 452-460 NN denotes Ubce7ip5
T19598 461-464 CC denotes and
T19599 465-469 NN denotes Mmp9
T19600 469-470 : denotes ;
T19601 471-474 DT denotes all
T19603 475-477 IN denotes of
T19604 478-483 WDT denotes which
T19602 484-487 VBP denotes are
T19605 488-490 IN denotes on
T19606 491-495 NN denotes MMU2
T19607 495-496 -RRB- denotes )
T19587 497-500 VBP denotes are
T19608 501-503 IN denotes of
T19609 504-514 JJ denotes particular
T19610 515-523 NN denotes interest
T19611 523-524 . denotes .
T19612 524-647 sentence denotes It has been suggested the Socs2 may rely on ubiquitination dependent proteasomal degradation to inhibit Gh signaling [23].
T19613 525-527 PRP denotes It
T19615 528-531 VBZ denotes has
T19616 532-536 VBN denotes been
T19614 537-546 VBN denotes suggested
T19617 547-550 DT denotes the
T19618 551-556 NN denotes Socs2
T19620 557-560 MD denotes may
T19619 561-565 VB denotes rely
T19621 566-568 IN denotes on
T19622 569-583 NN denotes ubiquitination
T19623 584-593 JJ denotes dependent
T19625 594-605 JJ denotes proteasomal
T19624 606-617 NN denotes degradation
T19626 618-620 TO denotes to
T19627 621-628 VB denotes inhibit
T19628 629-631 NN denotes Gh
T19629 632-641 NN denotes signaling
T19630 642-643 -LRB- denotes [
T19631 643-645 CD denotes 23
T19632 645-646 -RRB- denotes ]
T19633 646-647 . denotes .
T19634 647-821 sentence denotes Ubr1 and Ubce7ip5 are both involved in protein ubiquitination and Ubr1 knockout mice show an 20% decrease in body weight partly due to a reduction in adipose tissue [50,51].
T19635 648-652 NN denotes Ubr1
T19637 653-656 CC denotes and
T19638 657-665 NN denotes Ubce7ip5
T19639 666-669 VBP denotes are
T19640 670-674 RB denotes both
T19636 675-683 VBN denotes involved
T19641 684-686 IN denotes in
T19642 687-694 NN denotes protein
T19643 695-709 NN denotes ubiquitination
T19644 710-713 CC denotes and
T19645 714-718 NN denotes Ubr1
T19646 719-727 NN denotes knockout
T19647 728-732 NNS denotes mice
T19648 733-737 VBP denotes show
T19649 738-740 DT denotes an
T19651 741-743 CD denotes 20
T19652 743-744 NN denotes %
T19650 745-753 NN denotes decrease
T19653 754-756 IN denotes in
T19654 757-761 NN denotes body
T19655 762-768 NN denotes weight
T19656 769-775 RB denotes partly
T19657 776-779 IN denotes due
T19658 780-782 IN denotes to
T19659 783-784 DT denotes a
T19660 785-794 NN denotes reduction
T19661 795-797 IN denotes in
T19662 798-805 NN denotes adipose
T19663 806-812 NN denotes tissue
T19664 813-814 -LRB- denotes [
T19666 814-816 CD denotes 50
T19667 816-817 , denotes ,
T19665 817-819 CD denotes 51
T19668 819-820 -RRB- denotes ]
T19669 820-821 . denotes .
T19670 821-978 sentence denotes Ptpns1 knockout mice displayed a 10% reduction in body weight [52] and Mmp9 knockout mice show a reduction in size and drastically reduced bone length [53].
T19671 822-828 NN denotes Ptpns1
T19673 829-837 NN denotes knockout
T19672 838-842 NNS denotes mice
T19674 843-852 VBD denotes displayed
T19675 853-854 DT denotes a
T19677 855-857 CD denotes 10
T19678 857-858 NN denotes %
T19676 859-868 NN denotes reduction
T19679 869-871 IN denotes in
T19680 872-876 NN denotes body
T19681 877-883 NN denotes weight
T19682 884-885 -LRB- denotes [
T19683 885-887 CD denotes 52
T19684 887-888 -RRB- denotes ]
T19685 889-892 CC denotes and
T19686 893-897 NN denotes Mmp9
T19688 898-906 NN denotes knockout
T19687 907-911 NNS denotes mice
T19689 912-916 VBP denotes show
T19690 917-918 DT denotes a
T19691 919-928 NN denotes reduction
T19692 929-931 IN denotes in
T19693 932-936 NN denotes size
T19694 937-940 CC denotes and
T19695 941-952 RB denotes drastically
T19696 953-960 VBN denotes reduced
T19698 961-965 NN denotes bone
T19697 966-972 NN denotes length
T19699 973-974 -LRB- denotes [
T19700 974-976 CD denotes 53
T19701 976-977 -RRB- denotes ]
T19702 977-978 . denotes .
T19703 978-1140 sentence denotes All of these genes are excellent functional and positional hg modifier candidate genes and this information can be incorporated into future fine mapping studies.
T19704 979-982 DT denotes All
T19706 983-985 IN denotes of
T19707 986-991 DT denotes these
T19708 992-997 NNS denotes genes
T19705 998-1001 VBP denotes are
T19709 1002-1011 JJ denotes excellent
T19711 1012-1022 JJ denotes functional
T19712 1023-1026 CC denotes and
T19713 1027-1037 JJ denotes positional
T19714 1038-1040 NN denotes hg
T19715 1041-1049 NN denotes modifier
T19716 1050-1059 NN denotes candidate
T19710 1060-1065 NNS denotes genes
T19717 1066-1069 CC denotes and
T19718 1070-1074 DT denotes this
T19719 1075-1086 NN denotes information
T19721 1087-1090 MD denotes can
T19722 1091-1093 VB denotes be
T19720 1094-1106 VBN denotes incorporated
T19723 1107-1111 IN denotes into
T19724 1112-1118 JJ denotes future
T19726 1119-1123 JJ denotes fine
T19727 1124-1131 NN denotes mapping
T19725 1132-1139 NNS denotes studies
T19728 1139-1140 . denotes .
R5830 T19502 T19503 advmod More,importantly
R5831 T19503 T19504 advmod importantly,allowed
R5833 T19505 T19504 punct ", ",allowed
R5834 T19506 T19504 csubj sequencing,allowed
R5836 T19507 T19508 compound hg,modifier
R5837 T19508 T19509 compound modifier,candidates
R5838 T19509 T19506 dobj candidates,sequencing
R5840 T19510 T19511 nsubj us,identify
R5841 T19511 T19504 ccomp identify,allowed
R5842 T19512 T19511 aux to,identify
R5843 T19513 T19514 amod nonsynonomous,polymorphism
R5844 T19514 T19511 dobj polymorphism,identify
R5845 T19515 T19514 punct ", ",polymorphism
R5847 T19516 T19517 dep which,underlie
R5848 T19517 T19514 relcl underlie,polymorphism
R5849 T19518 T19517 aux may,underlie
R5851 T19519 T19517 dobj QTL,underlie
R5852 T19520 T19504 punct .,allowed
R5854 T19522 T19523 nsubj SIFT,predicted
R5855 T19524 T19522 cc and,SIFT
R5856 T19525 T19524 punct /,and
R5858 T19526 T19524 cc or,and
R5859 T19527 T19522 conj PolyPhen,SIFT
R5860 T19528 T19523 dobj alterations,predicted
R5861 T19529 T19528 prep in,alterations
R5863 T19530 T19531 compound protein,function
R5864 T19531 T19529 pobj function,in
R5866 T19532 T19528 prep for,alterations
R5867 T19533 T19532 pobj 15,for
R5868 T19534 T19533 prep of,15
R5870 T19535 T19536 det the,nsSNP
R5871 T19536 T19534 pobj nsSNP,of
R5877 T19537 T19536 nummod 56,nsSNP
R5878 T19538 T19536 amod total,nsSNP
R5884 T19539 T19540 punct (,%
R5886 T19540 T19533 parataxis %,15
R5887 T19541 T19540 nummod 27,%
R5889 T19542 T19540 punct ),%
R5890 T19543 T19533 prep in,15
R5892 T19544 T19543 pobj nine,in
R5893 T19545 T19544 prep of,nine
R5894 T19546 T19547 det the,genes
R5895 T19547 T19545 pobj genes,of
R5896 T19548 T19547 nummod 44,genes
R5898 T19549 T19547 amod total,genes
R5899 T19550 T19551 punct (,%
R5900 T19551 T19543 parataxis %,in
R5902 T19552 T19551 nummod 20,%
R5903 T19553 T19551 punct ),%
R5905 T19554 T19555 punct (,Table
R5906 T19555 T19523 parataxis Table,predicted
R5907 T19556 T19555 nummod 7,Table
R5909 T19557 T19555 punct ),Table
R5910 T19558 T19523 punct .,predicted
R5912 T19560 T19561 nsubjpass It,shown
R5914 T19562 T19561 aux has,shown
R5915 T19563 T19561 auxpass been,shown
R5917 T19564 T19565 mark that,is
R5918 T19565 T19561 ccomp is,shown
R5919 T19566 T19565 csubj predicting,is
R5924 T19567 T19566 dobj function,predicting
R5925 T19568 T19566 prep based,predicting
R5927 T19569 T19568 prep on,based
R5928 T19570 T19571 amod evolutionary,conservation
R5929 T19571 T19569 pobj conservation,on
R5931 T19572 T19566 advcl using,predicting
R5932 T19573 T19572 dobj programs,using
R5933 T19574 T19575 amod such,as
R5935 T19575 T19573 prep as,programs
R5936 T19576 T19575 pobj SIFT,as
R5937 T19577 T19576 cc and,SIFT
R5939 T19578 T19576 conj PolyPhen,SIFT
R5940 T19579 T19580 advmod very,accurate
R5941 T19580 T19565 acomp accurate,is
R5942 T19581 T19582 punct [,49
R5944 T19582 T19561 parataxis 49,shown
R5945 T19583 T19582 punct ],49
R5947 T19584 T19561 punct .,shown
R5948 T19586 T19587 nsubj Four,are
R5950 T19588 T19586 prep of,Four
R5951 T19589 T19590 det the,genes
R5953 T19590 T19588 pobj genes,of
R5954 T19591 T19590 nummod nine,genes
R5956 T19592 T19586 punct (,Four
R5957 T19593 T19586 appos Ubr1,Four
R5958 T19594 T19593 punct ", ",Ubr1
R5960 T19595 T19593 conj Ptpns1,Ubr1
R5961 T19596 T19595 punct ", ",Ptpns1
R5963 T19597 T19595 conj Ubce7ip5,Ptpns1
R5964 T19598 T19597 cc and,Ubce7ip5
R5966 T19599 T19597 conj Mmp9,Ubce7ip5
R5967 T19600 T19593 punct ;,Ubr1
R5969 T19601 T19602 dep all,are
R5970 T19602 T19593 relcl are,Ubr1
R5971 T19603 T19601 prep of,all
R5973 T19604 T19603 pobj which,of
R5974 T19605 T19602 prep on,are
R5975 T19606 T19605 pobj MMU2,on
R5977 T19607 T19587 punct ),are
R5978 T19608 T19587 prep of,are
R5979 T19609 T19610 amod particular,interest
R5981 T19610 T19608 pobj interest,of
R5982 T19611 T19587 punct .,are
R5984 T19613 T19614 nsubjpass It,suggested
R5986 T19615 T19614 aux has,suggested
R5987 T19616 T19614 auxpass been,suggested
R5989 T19617 T19618 det the,Socs2
R5990 T19618 T19619 nsubj Socs2,rely
R5991 T19619 T19614 advcl rely,suggested
R5993 T19620 T19619 aux may,rely
R5994 T19621 T19619 prep on,rely
R5996 T19622 T19623 npadvmod ubiquitination,dependent
R5997 T19623 T19624 amod dependent,degradation
R5998 T19624 T19621 pobj degradation,on
R5999 T19625 T19624 amod proteasomal,degradation
R6002 T19626 T19627 aux to,inhibit
R6003 T19627 T19619 advcl inhibit,rely
R6004 T19628 T19629 compound Gh,signaling
R6005 T19629 T19627 dobj signaling,inhibit
R6006 T19630 T19631 punct [,23
R6008 T19631 T19614 parataxis 23,suggested
R6009 T19632 T19631 punct ],23
R6010 T19633 T19614 punct .,suggested
R6012 T19635 T19636 nsubjpass Ubr1,involved
R6014 T19637 T19635 cc and,Ubr1
R6015 T19638 T19635 conj Ubce7ip5,Ubr1
R6017 T19639 T19636 auxpass are,involved
R6018 T19640 T19636 advmod both,involved
R6019 T19641 T19636 prep in,involved
R6020 T19642 T19643 compound protein,ubiquitination
R6022 T19643 T19641 pobj ubiquitination,in
R6023 T19644 T19636 cc and,involved
R6024 T19645 T19646 compound Ubr1,knockout
R6025 T19646 T19647 compound knockout,mice
R6027 T19647 T19648 nsubj mice,show
R6028 T19648 T19636 conj show,involved
R6030 T19649 T19650 det an,decrease
R6031 T19650 T19648 dobj decrease,show
R6032 T19651 T19652 nummod 20,%
R6034 T19652 T19650 compound %,decrease
R6035 T19653 T19650 prep in,decrease
R6036 T19654 T19655 compound body,weight
R6038 T19655 T19653 pobj weight,in
R6039 T19656 T19657 advmod partly,due
R6041 T19657 T19648 prep due,show
R6042 T19658 T19657 pcomp to,due
R6043 T19659 T19660 det a,reduction
R6045 T19660 T19657 pobj reduction,due
R6046 T19661 T19660 prep in,reduction
R6048 T19662 T19663 compound adipose,tissue
R6049 T19663 T19661 pobj tissue,in
R6050 T19664 T19665 punct [,51
R6051 T19665 T19648 parataxis 51,show
R6052 T19666 T19665 nummod 50,51
R6053 T19667 T19665 punct ",",51
R6055 T19668 T19665 punct ],51
R6056 T19669 T19648 punct .,show
R6058 T19671 T19672 compound Ptpns1,mice
R6059 T19672 T19674 nsubj mice,displayed
R6061 T19673 T19672 compound knockout,mice
R6063 T19675 T19676 det a,reduction
R6064 T19676 T19674 dobj reduction,displayed
R6065 T19677 T19678 nummod 10,%
R6067 T19678 T19676 compound %,reduction
R6068 T19679 T19676 prep in,reduction
R6069 T19680 T19681 compound body,weight
R6071 T19681 T19679 pobj weight,in
R6072 T19682 T19683 punct [,52
R6074 T19683 T19674 parataxis 52,displayed
R6075 T19684 T19683 punct ],52
R6076 T19685 T19674 cc and,displayed
R6078 T19686 T19687 compound Mmp9,mice
R6079 T19687 T19689 nsubj mice,show
R6081 T19688 T19687 compound knockout,mice
R6082 T19689 T19674 conj show,displayed
R6085 T19690 T19691 det a,reduction
R6086 T19691 T19689 dobj reduction,show
R6088 T19692 T19691 prep in,reduction
R6089 T19693 T19692 pobj size,in
R6090 T19694 T19691 cc and,reduction
R6092 T19695 T19696 advmod drastically,reduced
R6093 T19696 T19697 amod reduced,length
R6095 T19697 T19691 conj length,reduction
R6096 T19698 T19697 compound bone,length
R6097 T19699 T19700 punct [,53
R6099 T19700 T19689 parataxis 53,show
R6100 T19701 T19700 punct ],53
R6101 T19702 T19689 punct .,show
R6103 T19704 T19705 nsubj All,are
R6104 T19706 T19704 prep of,All
R6106 T19707 T19708 det these,genes
R6107 T19708 T19706 pobj genes,of
R6109 T19709 T19710 amod excellent,genes
R6112 T19710 T19705 attr genes,are
R6114 T19711 T19710 amod functional,genes
R6115 T19712 T19711 cc and,functional
R6117 T19713 T19711 conj positional,functional
R6118 T19714 T19715 compound hg,modifier
R6120 T19715 T19710 compound modifier,genes
R6121 T19716 T19710 compound candidate,genes
R6122 T19717 T19705 cc and,are
R6124 T19718 T19719 det this,information
R6125 T19719 T19720 nsubjpass information,incorporated
R6127 T19720 T19705 conj incorporated,are
R6128 T19721 T19720 aux can,incorporated
R6129 T19722 T19720 auxpass be,incorporated
R6130 T19723 T19720 prep into,incorporated
R6131 T19724 T19725 amod future,studies
R6133 T19725 T19723 pobj studies,into
R6134 T19726 T19727 amod fine,mapping
R6135 T19727 T19725 compound mapping,studies
R6136 T19728 T19720 punct .,incorporated