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PMC:1482699 / 23577-24926 JSONTXT 4 Projects

Annnotations TAB TSV DIC JSON TextAE

Id Subject Object Predicate Lexical cue
T17847 0-3 CD denotes One
T17848 4-13 NN denotes criticism
T17850 14-16 IN denotes of
T17851 17-20 DT denotes the
T17853 21-26 NN denotes speed
T17854 27-35 JJ denotes congenic
T17852 36-44 NN denotes approach
T17849 45-47 VBZ denotes is
T17855 48-51 DT denotes the
T17856 52-61 NN denotes potential
T17857 62-65 IN denotes for
T17859 66-69 NN denotes QTL
T17860 70-72 TO denotes to
T17858 73-79 VB denotes reside
T17861 80-85 IN denotes among
T17862 86-94 JJ denotes unwanted
T17864 95-100 NN denotes donor
T17863 101-108 NNS denotes alleles
T17865 109-112 RB denotes not
T17866 113-123 VBN denotes eliminated
T17867 124-130 IN denotes during
T17868 131-143 NN denotes backcrossing
T17869 143-144 . denotes .
T17870 144-272 sentence denotes In this case differences between the congenic and control strains would be due in part or whole to these contaminating alleles.
T17871 145-147 IN denotes In
T17873 148-152 DT denotes this
T17874 153-157 NN denotes case
T17875 158-169 NNS denotes differences
T17876 170-177 IN denotes between
T17877 178-181 DT denotes the
T17879 182-190 JJ denotes congenic
T17880 191-194 CC denotes and
T17881 195-202 NN denotes control
T17878 203-210 NNS denotes strains
T17882 211-216 MD denotes would
T17872 217-219 VB denotes be
T17883 220-223 IN denotes due
T17884 224-226 IN denotes in
T17885 227-231 NN denotes part
T17886 232-234 CC denotes or
T17887 235-240 NN denotes whole
T17888 241-243 IN denotes to
T17889 244-249 DT denotes these
T17891 250-263 VBG denotes contaminating
T17890 264-271 NNS denotes alleles
T17892 271-272 . denotes .
T17893 272-346 sentence denotes We took several precautions to reduce the probability of this occurrence.
T17894 273-275 PRP denotes We
T17895 276-280 VBD denotes took
T17896 281-288 JJ denotes several
T17897 289-300 NNS denotes precautions
T17898 301-303 TO denotes to
T17899 304-310 VB denotes reduce
T17900 311-314 DT denotes the
T17901 315-326 NN denotes probability
T17902 327-329 IN denotes of
T17903 330-334 DT denotes this
T17904 335-345 NN denotes occurrence
T17905 345-346 . denotes .
T17906 346-459 sentence denotes First, our control strains were developed from mice undergoing the same selection as all of the other congenics.
T17907 347-352 RB denotes First
T17909 352-354 , denotes ,
T17910 354-357 PRP$ denotes our
T17912 358-365 NN denotes control
T17911 366-373 NNS denotes strains
T17913 374-378 VBD denotes were
T17908 379-388 VBN denotes developed
T17914 389-393 IN denotes from
T17915 394-398 NNS denotes mice
T17916 399-409 VBG denotes undergoing
T17917 410-413 DT denotes the
T17919 414-418 JJ denotes same
T17918 419-428 NN denotes selection
T17920 429-431 IN denotes as
T17921 432-435 DT denotes all
T17922 436-438 IN denotes of
T17923 439-442 DT denotes the
T17925 443-448 JJ denotes other
T17924 449-458 NNS denotes congenics
T17926 458-459 . denotes .
T17927 459-589 sentence denotes Therefore, it is possible that any unwanted QTL or mutations arising during congenic construction are shared between all strains.
T17928 460-469 RB denotes Therefore
T17930 469-471 , denotes ,
T17931 471-473 PRP denotes it
T17929 474-476 VBZ denotes is
T17932 477-485 JJ denotes possible
T17933 486-490 IN denotes that
T17935 491-494 DT denotes any
T17937 495-503 JJ denotes unwanted
T17936 504-507 NN denotes QTL
T17938 508-510 CC denotes or
T17939 511-520 NNS denotes mutations
T17940 521-528 VBG denotes arising
T17941 529-535 IN denotes during
T17942 536-544 JJ denotes congenic
T17943 545-557 NN denotes construction
T17944 558-561 VBP denotes are
T17934 562-568 VBN denotes shared
T17945 569-576 IN denotes between
T17946 577-580 DT denotes all
T17947 581-588 NNS denotes strains
T17948 588-589 . denotes .
T17949 589-708 sentence denotes More importantly, we have knowledge of all large previously detected growth and obesity QTL in the current cross [24].
T17950 590-594 RBR denotes More
T17951 595-606 RB denotes importantly
T17953 606-608 , denotes ,
T17954 608-610 PRP denotes we
T17952 611-615 VBP denotes have
T17955 616-625 NN denotes knowledge
T17956 626-628 IN denotes of
T17957 629-632 DT denotes all
T17959 633-638 JJ denotes large
T17960 639-649 RB denotes previously
T17961 650-658 VBN denotes detected
T17962 659-665 NN denotes growth
T17963 666-669 CC denotes and
T17964 670-677 NN denotes obesity
T17958 678-681 NN denotes QTL
T17965 682-684 IN denotes in
T17966 685-688 DT denotes the
T17968 689-696 JJ denotes current
T17967 697-702 NN denotes cross
T17969 703-704 -LRB- denotes [
T17970 704-706 CD denotes 24
T17971 706-707 -RRB- denotes ]
T17972 707-708 . denotes .
T17973 708-907 sentence denotes Using this information we increased the density of markers in each QTL region (MMU1, 2, 5, 8, 9, 11 and 17; Table 1 and Additional File 1), ensuring the absence of CAST alleles at each of these QTL.
T17974 709-714 VBG denotes Using
T17976 715-719 DT denotes this
T17977 720-731 NN denotes information
T17978 732-734 PRP denotes we
T17975 735-744 VBD denotes increased
T17979 745-748 DT denotes the
T17980 749-756 NN denotes density
T17981 757-759 IN denotes of
T17982 760-767 NNS denotes markers
T17983 768-770 IN denotes in
T17984 771-775 DT denotes each
T17986 776-779 NN denotes QTL
T17985 780-786 NN denotes region
T17987 787-788 -LRB- denotes (
T17989 788-791 NN denotes MMU
T17990 791-792 CD denotes 1
T17991 792-794 , denotes ,
T17992 794-795 CD denotes 2
T17993 795-797 , denotes ,
T17994 797-798 CD denotes 5
T17995 798-800 , denotes ,
T17996 800-801 CD denotes 8
T17997 801-803 , denotes ,
T17998 803-804 CD denotes 9
T17999 804-806 , denotes ,
T18000 806-808 CD denotes 11
T18001 809-812 CC denotes and
T18002 813-815 CD denotes 17
T18003 815-816 : denotes ;
T17988 817-822 NN denotes Table
T18004 823-824 CD denotes 1
T18005 825-828 CC denotes and
T18006 829-839 JJ denotes Additional
T18007 840-844 NN denotes File
T18008 845-846 CD denotes 1
T18009 846-847 -RRB- denotes )
T18010 847-849 , denotes ,
T18011 849-857 VBG denotes ensuring
T18012 858-861 DT denotes the
T18013 862-869 NN denotes absence
T18014 870-872 IN denotes of
T18015 873-877 NN denotes CAST
T18016 878-885 NNS denotes alleles
T18017 886-888 IN denotes at
T18018 889-893 DT denotes each
T18019 894-896 IN denotes of
T18020 897-902 DT denotes these
T18021 903-906 NN denotes QTL
T18022 906-907 . denotes .
T18023 907-1066 sentence denotes This approach, termed "QTL-Marker-Assisted Counter Selection" or QMACS, has been previously used to characterize QTL for hypnotic sensitivity to ethanol [31].
T18024 908-912 DT denotes This
T18025 913-921 NN denotes approach
T18027 921-923 , denotes ,
T18028 923-929 VBN denotes termed
T18029 930-931 `` denotes "
T18030 931-934 NN denotes QTL
T18032 934-935 HYPH denotes -
T18031 935-941 NN denotes Marker
T18034 941-942 HYPH denotes -
T18033 942-950 VBN denotes Assisted
T18036 951-958 NN denotes Counter
T18035 959-968 NN denotes Selection
T18037 968-969 '' denotes "
T18038 970-972 CC denotes or
T18039 973-978 NN denotes QMACS
T18040 978-980 , denotes ,
T18041 980-983 VBZ denotes has
T18042 984-988 VBN denotes been
T18043 989-999 RB denotes previously
T18026 1000-1004 VBN denotes used
T18044 1005-1007 TO denotes to
T18045 1008-1020 VB denotes characterize
T18046 1021-1024 NN denotes QTL
T18047 1025-1028 IN denotes for
T18048 1029-1037 JJ denotes hypnotic
T18049 1038-1049 NN denotes sensitivity
T18050 1050-1052 IN denotes to
T18051 1053-1060 NN denotes ethanol
T18052 1061-1062 -LRB- denotes [
T18053 1062-1064 CD denotes 31
T18054 1064-1065 -RRB- denotes ]
T18055 1065-1066 . denotes .
T18056 1066-1144 sentence denotes In that study, only markers flanking QTL were typed, not genome-wide markers.
T18057 1067-1069 IN denotes In
T18059 1070-1074 DT denotes that
T18060 1075-1080 NN denotes study
T18061 1080-1082 , denotes ,
T18062 1082-1086 RB denotes only
T18063 1087-1094 NNS denotes markers
T18064 1095-1103 VBG denotes flanking
T18065 1104-1107 NN denotes QTL
T18066 1108-1112 VBD denotes were
T18058 1113-1118 VBN denotes typed
T18067 1118-1120 , denotes ,
T18068 1120-1123 CC denotes not
T18070 1124-1130 NN denotes genome
T18072 1130-1131 HYPH denotes -
T18071 1131-1135 JJ denotes wide
T18069 1136-1143 NNS denotes markers
T18073 1143-1144 . denotes .
T18074 1144-1349 sentence denotes In contrast, we selected not only against known QTL, we also screened for genome wide heterozygosity increasing the probability that effects observed are due to genetic variation within each donor region.
T18075 1145-1147 IN denotes In
T18077 1148-1156 NN denotes contrast
T18078 1156-1158 , denotes ,
T18079 1158-1160 PRP denotes we
T18080 1161-1169 VBD denotes selected
T18081 1170-1173 RB denotes not
T18082 1174-1178 RB denotes only
T18083 1179-1186 IN denotes against
T18084 1187-1192 VBN denotes known
T18085 1193-1196 NN denotes QTL
T18086 1196-1198 , denotes ,
T18087 1198-1200 PRP denotes we
T18088 1201-1205 RB denotes also
T18076 1206-1214 VBD denotes screened
T18089 1215-1218 IN denotes for
T18090 1219-1225 NN denotes genome
T18091 1226-1230 JJ denotes wide
T18092 1231-1245 NN denotes heterozygosity
T18093 1246-1256 VBG denotes increasing
T18094 1257-1260 DT denotes the
T18095 1261-1272 NN denotes probability
T18096 1273-1277 IN denotes that
T18098 1278-1285 NNS denotes effects
T18099 1286-1294 VBN denotes observed
T18097 1295-1298 VBP denotes are
T18100 1299-1302 IN denotes due
T18101 1303-1305 IN denotes to
T18102 1306-1313 JJ denotes genetic
T18103 1314-1323 NN denotes variation
T18104 1324-1330 IN denotes within
T18105 1331-1335 DT denotes each
T18107 1336-1341 NN denotes donor
T18106 1342-1348 NN denotes region
T18108 1348-1349 . denotes .
R4454 T18103 T18100 pobj variation,due
R4456 T18104 T18103 prep within,variation
R4458 T18105 T18106 det each,region
R4459 T18106 T18104 pobj region,within
R4460 T17847 T17848 nummod One,criticism
R4461 T18107 T18106 compound donor,region
R4462 T18108 T18076 punct .,screened
R4463 T17848 T17849 nsubj criticism,is
R4466 T17850 T17848 prep of,criticism
R4470 T17851 T17852 det the,approach
R4473 T17852 T17850 pobj approach,of
R4476 T17853 T17854 npadvmod speed,congenic
R4480 T17854 T17852 amod congenic,approach
R4484 T17855 T17856 det the,potential
R4486 T17856 T17849 attr potential,is
R4487 T17857 T17858 mark for,reside
R4488 T17858 T17856 advcl reside,potential
R4489 T17859 T17858 nsubj QTL,reside
R4494 T17860 T17858 aux to,reside
R4498 T17861 T17858 prep among,reside
R4500 T17862 T17863 amod unwanted,alleles
R4506 T17863 T17861 pobj alleles,among
R4516 T17864 T17863 compound donor,alleles
R4519 T17865 T17866 neg not,eliminated
R4522 T17866 T17863 acl eliminated,alleles
R4525 T17867 T17866 prep during,eliminated
R4529 T17868 T17867 pobj backcrossing,during
R4533 T17869 T17849 punct .,is
R4536 T17871 T17872 prep In,be
R4541 T17873 T17874 det this,case
R4549 T17874 T17871 pobj case,In
R4553 T17875 T17872 nsubj differences,be
R4557 T17876 T17875 prep between,differences
R4561 T17877 T17878 det the,strains
R4563 T17878 T17876 pobj strains,between
R4566 T17879 T17878 amod congenic,strains
R4569 T17880 T17879 cc and,congenic
R4573 T17881 T17879 conj control,congenic
R4577 T17882 T17872 aux would,be
R4581 T17883 T17872 prep due,be
R4585 T17884 T17883 prep in,due
R4588 T17885 T17884 pobj part,in
R4589 T17886 T17885 cc or,part
R4592 T17887 T17885 conj whole,part
R4596 T17888 T17883 pcomp to,due
R4598 T17889 T17890 det these,alleles
R4599 T17890 T17883 pobj alleles,due
R4600 T17891 T17890 amod contaminating,alleles
R4601 T17892 T17872 punct .,be
R4602 T17894 T17895 nsubj We,took
R4606 T17896 T17897 amod several,precautions
R4609 T17897 T17895 dobj precautions,took
R4613 T17898 T17899 aux to,reduce
R4616 T17899 T17895 advcl reduce,took
R4620 T17900 T17901 det the,probability
R4624 T17901 T17899 dobj probability,reduce
R4628 T17902 T17901 prep of,probability
R4631 T17903 T17904 det this,occurrence
R4635 T17904 T17902 pobj occurrence,of
R4637 T17905 T17895 punct .,took
R4640 T17907 T17908 advmod First,developed
R4645 T17909 T17908 punct ", ",developed
R4651 T17910 T17911 poss our,strains
R4654 T17911 T17908 nsubjpass strains,developed
R4658 T17912 T17911 compound control,strains
R4661 T17913 T17908 auxpass were,developed
R4664 T17914 T17908 prep from,developed
R4667 T17915 T17914 pobj mice,from
R4671 T17916 T17915 acl undergoing,mice
R4675 T17917 T17918 det the,selection
R4678 T17918 T17916 dobj selection,undergoing
R4681 T17919 T17918 amod same,selection
R4685 T17920 T17918 prep as,selection
R4689 T17921 T17920 pobj all,as
R4693 T17922 T17921 prep of,all
R4697 T17923 T17924 det the,congenics
R4702 T17924 T17922 pobj congenics,of
R4705 T17925 T17924 amod other,congenics
R4709 T17926 T17908 punct .,developed
R4712 T17928 T17929 advmod Therefore,is
R4714 T17930 T17929 punct ", ",is
R4715 T17931 T17929 nsubj it,is
R4716 T17932 T17929 acomp possible,is
R4718 T17933 T17934 mark that,shared
R4721 T17934 T17929 ccomp shared,is
R4725 T17935 T17936 det any,QTL
R4729 T17936 T17934 nsubjpass QTL,shared
R4730 T17937 T17936 amod unwanted,QTL
R4732 T17938 T17936 cc or,QTL
R4735 T17939 T17936 conj mutations,QTL
R4737 T17940 T17939 acl arising,mutations
R4741 T17941 T17940 prep during,arising
R4744 T17942 T17943 amod congenic,construction
R4747 T17943 T17941 pobj construction,during
R4753 T17944 T17934 auxpass are,shared
R4757 T17945 T17934 prep between,shared
R4762 T17946 T17947 det all,strains
R4765 T17947 T17945 pobj strains,between
R4766 T17948 T17929 punct .,is
R4767 T17950 T17951 advmod More,importantly
R4768 T17951 T17952 advmod importantly,have
R4769 T17953 T17952 punct ", ",have
R4770 T17954 T17952 nsubj we,have
R4772 T17955 T17952 dobj knowledge,have
R4780 T17956 T17955 prep of,knowledge
R4785 T17957 T17958 det all,QTL
R4789 T17958 T17956 pobj QTL,of
R4792 T17959 T17958 amod large,QTL
R4796 T17960 T17961 advmod previously,detected
R4799 T17961 T17958 amod detected,QTL
R4801 T17962 T17958 nmod growth,QTL
R4807 T17963 T17962 cc and,growth
R4811 T17964 T17962 conj obesity,growth
R4814 T17965 T17958 prep in,QTL
R4818 T17966 T17967 det the,cross
R4820 T17967 T17965 pobj cross,in
R4823 T17968 T17967 amod current,cross
R4826 T17969 T17970 punct [,24
R4830 T17970 T17952 parataxis 24,have
R4834 T17971 T17970 punct ],24
R4835 T17972 T17952 punct .,have
R4836 T17974 T17975 advcl Using,increased
R4837 T17976 T17977 det this,information
R4839 T17977 T17974 dobj information,Using
R4842 T17978 T17975 nsubj we,increased
R4845 T17979 T17980 det the,density
R4849 T17980 T17975 dobj density,increased
R4852 T17981 T17980 prep of,density
R4858 T17982 T17981 pobj markers,of
R4862 T17983 T17980 prep in,density
R4866 T17984 T17985 det each,region
R4868 T17985 T17983 pobj region,in
R4872 T17986 T17985 compound QTL,region
R4873 T17987 T17988 punct (,Table
R4875 T17988 T17975 parataxis Table,increased
R4877 T17989 T17990 nmod MMU,1
R4880 T17990 T17988 dep 1,Table
R4884 T17991 T17990 punct ", ",1
R4887 T17992 T17990 conj 2,1
R4890 T17993 T17992 punct ", ",2
R4893 T17994 T17992 conj 5,2
R4896 T17995 T17994 punct ", ",5
R4900 T17996 T17994 conj 8,5
R4904 T17997 T17996 punct ", ",8
R4908 T17998 T17996 conj 9,8
R4912 T17999 T17998 punct ", ",9
R4916 T18000 T17998 conj 11,9
R4919 T18001 T18000 cc and,11
R4923 T18002 T18000 conj 17,11
R4926 T18003 T17988 punct ;,Table
R4930 T18004 T17988 nummod 1,Table
R4933 T18005 T17988 cc and,Table
R4936 T18006 T18007 amod Additional,File
R4938 T18007 T17988 conj File,Table
R4940 T18008 T18007 nummod 1,File
R4941 T18009 T17988 punct ),Table
R4942 T18010 T17975 punct ", ",increased
R4943 T18011 T17975 advcl ensuring,increased
R4944 T18012 T18013 det the,absence
R4948 T18013 T18011 dobj absence,ensuring
R4952 T18014 T18013 prep of,absence
R4955 T18015 T18016 compound CAST,alleles
R4958 T18016 T18014 pobj alleles,of
R4959 T18017 T18013 prep at,absence
R4960 T18018 T18017 pobj each,at
R4962 T18019 T18018 prep of,each
R4966 T18020 T18021 det these,QTL
R4970 T18021 T18019 pobj QTL,of
R4973 T18022 T17975 punct .,increased
R4975 T18024 T18025 det This,approach
R4979 T18025 T18026 nsubjpass approach,used
R4982 T18027 T18025 punct ", ",approach
R4988 T18028 T18025 acl termed,approach
R4991 T18029 T18028 punct """",termed
R4995 T18030 T18031 compound QTL,Marker
R4998 T18031 T18033 npadvmod Marker,Assisted
R5002 T18032 T18031 punct -,Marker
R5004 T18033 T18035 amod Assisted,Selection
R5007 T18034 T18033 punct -,Assisted
R5012 T18035 T18028 oprd Selection,termed
R5017 T18036 T18035 compound Counter,Selection
R5018 T18037 T18035 punct """",Selection
R5020 T18038 T18035 cc or,Selection
R5023 T18039 T18035 conj QMACS,Selection
R5026 T18040 T18026 punct ", ",used
R5031 T18041 T18026 aux has,used
R5034 T18042 T18026 auxpass been,used
R5036 T18043 T18026 advmod previously,used
R5040 T18044 T18045 aux to,characterize
R5043 T18045 T18026 advcl characterize,used
R5046 T18046 T18045 dobj QTL,characterize
R5050 T18047 T18045 prep for,characterize
R5053 T18048 T18049 amod hypnotic,sensitivity
R5057 T18049 T18047 pobj sensitivity,for
R5064 T18050 T18049 prep to,sensitivity
R5068 T18051 T18050 pobj ethanol,to
R5071 T18052 T18053 punct [,31
R5073 T18053 T18026 parataxis 31,used
R5075 T18054 T18053 punct ],31
R5076 T18055 T18026 punct .,used
R5077 T18057 T18058 prep In,typed
R5078 T18059 T18060 det that,study
R5079 T18060 T18057 pobj study,In
R5081 T18061 T18058 punct ", ",typed
R5084 T18062 T18063 advmod only,markers
R5088 T18063 T18058 nsubjpass markers,typed
R5091 T18064 T18063 acl flanking,markers
R5095 T18065 T18064 dobj QTL,flanking
R5099 T18066 T18058 auxpass were,typed
R5103 T18067 T18058 punct ", ",typed
R5105 T18068 T18069 cc not,markers
R5108 T18069 T18058 dep markers,typed
R5111 T18070 T18071 npadvmod genome,wide
R5117 T18071 T18069 amod wide,markers
R5121 T18072 T18071 punct -,wide
R5124 T18073 T18058 punct .,typed
R5128 T18075 T18076 prep In,screened
R5132 T18077 T18075 pobj contrast,In
R5135 T18078 T18076 punct ", ",screened
R5139 T18079 T18080 nsubj we,selected
R5142 T18080 T18076 ccomp selected,screened
R5146 T18081 T18080 preconj not,selected
R5150 T18082 T18081 advmod only,not
R5152 T18083 T18080 conj against,selected
R5156 T18084 T18085 amod known,QTL
R5158 T18085 T18083 pobj QTL,against
R5159 T18086 T18076 punct ", ",screened
R5162 T18087 T18076 nsubj we,screened
R5168 T18088 T18076 advmod also,screened
R5172 T18089 T18076 prep for,screened
R5175 T18090 T18091 npadvmod genome,wide
R5177 T18091 T18092 amod wide,heterozygosity
R5180 T18092 T18089 pobj heterozygosity,for
R5183 T18093 T18076 advcl increasing,screened
R5187 T18094 T18095 det the,probability
R5191 T18095 T18093 dobj probability,increasing
R5194 T18096 T18097 mark that,are
R5195 T18097 T18095 acl are,probability
R5196 T18098 T18097 nsubj effects,are
R5197 T18099 T18098 acl observed,effects
R5199 T18100 T18097 prep due,are
R5203 T18101 T18100 pcomp to,due
R5206 T18102 T18103 amod genetic,variation