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PMC:1482699 / 22780-33322 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T17718 11-16 NN denotes Speed
T17719 17-25 JJ denotes congenic
T17720 26-33 NNS denotes strains
T17721 34-41 VBP denotes provide
T17722 42-43 DT denotes a
T17724 44-52 JJ denotes powerful
T17723 53-61 NN denotes approach
T17725 62-64 TO denotes to
T17726 65-72 VB denotes confirm
T17727 73-76 CC denotes and
T17728 77-87 RB denotes physically
T17729 88-95 VB denotes confine
T17730 96-99 NN denotes QTL
T17731 100-106 IN denotes within
T17732 107-116 NNS denotes intervals
T17733 117-124 VBN denotes defined
T17734 125-127 IN denotes by
T17735 128-137 JJ denotes molecular
T17736 138-145 NNS denotes markers
T17737 145-146 . denotes .
T17738 146-367 sentence denotes In the current study, approximately 20% of the CAST genome harboring all previously detected growth and carcass composition QTL was isolated on an HG or B6 background through the development of 14 speed congenic strains.
T17739 147-149 IN denotes In
T17741 150-153 DT denotes the
T17743 154-161 JJ denotes current
T17742 162-167 NN denotes study
T17744 167-169 , denotes ,
T17745 169-182 RB denotes approximately
T17746 183-185 CD denotes 20
T17747 185-186 NN denotes %
T17748 187-189 IN denotes of
T17749 190-193 DT denotes the
T17751 194-198 NN denotes CAST
T17750 199-205 NN denotes genome
T17752 206-215 VBG denotes harboring
T17753 216-219 RB denotes all
T17755 220-230 RB denotes previously
T17756 231-239 VBN denotes detected
T17757 240-246 NN denotes growth
T17759 247-250 CC denotes and
T17760 251-258 NN denotes carcass
T17758 259-270 NN denotes composition
T17754 271-274 NN denotes QTL
T17761 275-278 VBD denotes was
T17740 279-287 VBN denotes isolated
T17762 288-290 IN denotes on
T17763 291-293 DT denotes an
T17765 294-296 NN denotes HG
T17766 297-299 CC denotes or
T17767 300-302 NN denotes B6
T17764 303-313 NN denotes background
T17768 314-321 IN denotes through
T17769 322-325 DT denotes the
T17770 326-337 NN denotes development
T17771 338-340 IN denotes of
T17772 341-343 CD denotes 14
T17774 344-349 NN denotes speed
T17775 350-358 JJ denotes congenic
T17773 359-366 NNS denotes strains
T17776 366-367 . denotes .
T17777 367-564 sentence denotes Two distinct speed congenic panels were developed, the first provided a comprehensive isolation of all MMU2 QTL between the B6, HG and CAST strains and the second targeted all QTL outside of MMU2.
T17778 368-371 CD denotes Two
T17780 372-380 JJ denotes distinct
T17781 381-386 NN denotes speed
T17782 387-395 JJ denotes congenic
T17779 396-402 NNS denotes panels
T17784 403-407 VBD denotes were
T17783 408-417 VBN denotes developed
T17786 417-419 , denotes ,
T17787 419-422 DT denotes the
T17788 423-428 JJ denotes first
T17785 429-437 VBD denotes provided
T17789 438-439 DT denotes a
T17791 440-453 JJ denotes comprehensive
T17790 454-463 NN denotes isolation
T17792 464-466 IN denotes of
T17793 467-470 DT denotes all
T17795 471-475 NN denotes MMU2
T17794 476-479 NN denotes QTL
T17796 480-487 IN denotes between
T17797 488-491 DT denotes the
T17799 492-494 NN denotes B6
T17800 494-496 , denotes ,
T17801 496-498 NN denotes HG
T17802 499-502 CC denotes and
T17803 503-507 NN denotes CAST
T17798 508-515 NNS denotes strains
T17804 516-519 CC denotes and
T17805 520-523 DT denotes the
T17806 524-530 NN denotes second
T17807 531-539 VBD denotes targeted
T17808 540-543 DT denotes all
T17809 544-547 NN denotes QTL
T17810 548-555 IN denotes outside
T17811 556-558 IN denotes of
T17812 559-563 NN denotes MMU2
T17813 563-564 . denotes .
T17814 564-662 sentence denotes Each successfully characterized strain exhibited phenotypic differences relative to control mice.
T17815 565-569 DT denotes Each
T17817 570-582 RB denotes successfully
T17818 583-596 VBN denotes characterized
T17816 597-603 NN denotes strain
T17819 604-613 VBD denotes exhibited
T17820 614-624 JJ denotes phenotypic
T17821 625-636 NNS denotes differences
T17822 637-645 JJ denotes relative
T17823 646-648 IN denotes to
T17824 649-656 NN denotes control
T17825 657-661 NNS denotes mice
T17826 661-662 . denotes .
T17827 662-796 sentence denotes These strains represent important resources and provide the genetic resource to positionally clone numerous quantitative trait genes.
T17828 663-668 DT denotes These
T17829 669-676 NNS denotes strains
T17830 677-686 VBP denotes represent
T17831 687-696 JJ denotes important
T17832 697-706 NNS denotes resources
T17833 707-710 CC denotes and
T17834 711-718 VB denotes provide
T17835 719-722 DT denotes the
T17837 723-730 JJ denotes genetic
T17836 731-739 NN denotes resource
T17838 740-742 TO denotes to
T17840 743-755 RB denotes positionally
T17839 756-761 VB denotes clone
T17841 762-770 JJ denotes numerous
T17843 771-783 JJ denotes quantitative
T17844 784-789 NN denotes trait
T17842 790-795 NNS denotes genes
T17845 795-796 . denotes .
T17846 796-941 sentence denotes One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing.
T17847 797-800 CD denotes One
T17848 801-810 NN denotes criticism
T17850 811-813 IN denotes of
T17851 814-817 DT denotes the
T17853 818-823 NN denotes speed
T17854 824-832 JJ denotes congenic
T17852 833-841 NN denotes approach
T17849 842-844 VBZ denotes is
T17855 845-848 DT denotes the
T17856 849-858 NN denotes potential
T17857 859-862 IN denotes for
T17859 863-866 NN denotes QTL
T17860 867-869 TO denotes to
T17858 870-876 VB denotes reside
T17861 877-882 IN denotes among
T17862 883-891 JJ denotes unwanted
T17864 892-897 NN denotes donor
T17863 898-905 NNS denotes alleles
T17865 906-909 RB denotes not
T17866 910-920 VBN denotes eliminated
T17867 921-927 IN denotes during
T17868 928-940 NN denotes backcrossing
T17869 940-941 . denotes .
T17870 941-1069 sentence denotes In this case differences between the congenic and control strains would be due in part or whole to these contaminating alleles.
T17871 942-944 IN denotes In
T17873 945-949 DT denotes this
T17874 950-954 NN denotes case
T17875 955-966 NNS denotes differences
T17876 967-974 IN denotes between
T17877 975-978 DT denotes the
T17879 979-987 JJ denotes congenic
T17880 988-991 CC denotes and
T17881 992-999 NN denotes control
T17878 1000-1007 NNS denotes strains
T17882 1008-1013 MD denotes would
T17872 1014-1016 VB denotes be
T17883 1017-1020 IN denotes due
T17884 1021-1023 IN denotes in
T17885 1024-1028 NN denotes part
T17886 1029-1031 CC denotes or
T17887 1032-1037 NN denotes whole
T17888 1038-1040 IN denotes to
T17889 1041-1046 DT denotes these
T17891 1047-1060 VBG denotes contaminating
T17890 1061-1068 NNS denotes alleles
T17892 1068-1069 . denotes .
T17893 1069-1143 sentence denotes We took several precautions to reduce the probability of this occurrence.
T17894 1070-1072 PRP denotes We
T17895 1073-1077 VBD denotes took
T17896 1078-1085 JJ denotes several
T17897 1086-1097 NNS denotes precautions
T17898 1098-1100 TO denotes to
T17899 1101-1107 VB denotes reduce
T17900 1108-1111 DT denotes the
T17901 1112-1123 NN denotes probability
T17902 1124-1126 IN denotes of
T17903 1127-1131 DT denotes this
T17904 1132-1142 NN denotes occurrence
T17905 1142-1143 . denotes .
T17906 1143-1256 sentence denotes First, our control strains were developed from mice undergoing the same selection as all of the other congenics.
T17907 1144-1149 RB denotes First
T17909 1149-1151 , denotes ,
T17910 1151-1154 PRP$ denotes our
T17912 1155-1162 NN denotes control
T17911 1163-1170 NNS denotes strains
T17913 1171-1175 VBD denotes were
T17908 1176-1185 VBN denotes developed
T17914 1186-1190 IN denotes from
T17915 1191-1195 NNS denotes mice
T17916 1196-1206 VBG denotes undergoing
T17917 1207-1210 DT denotes the
T17919 1211-1215 JJ denotes same
T17918 1216-1225 NN denotes selection
T17920 1226-1228 IN denotes as
T17921 1229-1232 DT denotes all
T17922 1233-1235 IN denotes of
T17923 1236-1239 DT denotes the
T17925 1240-1245 JJ denotes other
T17924 1246-1255 NNS denotes congenics
T17926 1255-1256 . denotes .
T17927 1256-1386 sentence denotes Therefore, it is possible that any unwanted QTL or mutations arising during congenic construction are shared between all strains.
T17928 1257-1266 RB denotes Therefore
T17930 1266-1268 , denotes ,
T17931 1268-1270 PRP denotes it
T17929 1271-1273 VBZ denotes is
T17932 1274-1282 JJ denotes possible
T17933 1283-1287 IN denotes that
T17935 1288-1291 DT denotes any
T17937 1292-1300 JJ denotes unwanted
T17936 1301-1304 NN denotes QTL
T17938 1305-1307 CC denotes or
T17939 1308-1317 NNS denotes mutations
T17940 1318-1325 VBG denotes arising
T17941 1326-1332 IN denotes during
T17942 1333-1341 JJ denotes congenic
T17943 1342-1354 NN denotes construction
T17944 1355-1358 VBP denotes are
T17934 1359-1365 VBN denotes shared
T17945 1366-1373 IN denotes between
T17946 1374-1377 DT denotes all
T17947 1378-1385 NNS denotes strains
T17948 1385-1386 . denotes .
T17949 1386-1505 sentence denotes More importantly, we have knowledge of all large previously detected growth and obesity QTL in the current cross [24].
T17950 1387-1391 RBR denotes More
T17951 1392-1403 RB denotes importantly
T17953 1403-1405 , denotes ,
T17954 1405-1407 PRP denotes we
T17952 1408-1412 VBP denotes have
T17955 1413-1422 NN denotes knowledge
T17956 1423-1425 IN denotes of
T17957 1426-1429 DT denotes all
T17959 1430-1435 JJ denotes large
T17960 1436-1446 RB denotes previously
T17961 1447-1455 VBN denotes detected
T17962 1456-1462 NN denotes growth
T17963 1463-1466 CC denotes and
T17964 1467-1474 NN denotes obesity
T17958 1475-1478 NN denotes QTL
T17965 1479-1481 IN denotes in
T17966 1482-1485 DT denotes the
T17968 1486-1493 JJ denotes current
T17967 1494-1499 NN denotes cross
T17969 1500-1501 -LRB- denotes [
T17970 1501-1503 CD denotes 24
T17971 1503-1504 -RRB- denotes ]
T17972 1504-1505 . denotes .
T17973 1505-1704 sentence denotes Using this information we increased the density of markers in each QTL region (MMU1, 2, 5, 8, 9, 11 and 17; Table 1 and Additional File 1), ensuring the absence of CAST alleles at each of these QTL.
T17974 1506-1511 VBG denotes Using
T17976 1512-1516 DT denotes this
T17977 1517-1528 NN denotes information
T17978 1529-1531 PRP denotes we
T17975 1532-1541 VBD denotes increased
T17979 1542-1545 DT denotes the
T17980 1546-1553 NN denotes density
T17981 1554-1556 IN denotes of
T17982 1557-1564 NNS denotes markers
T17983 1565-1567 IN denotes in
T17984 1568-1572 DT denotes each
T17986 1573-1576 NN denotes QTL
T17985 1577-1583 NN denotes region
T17987 1584-1585 -LRB- denotes (
T17989 1585-1588 NN denotes MMU
T17990 1588-1589 CD denotes 1
T17991 1589-1591 , denotes ,
T17992 1591-1592 CD denotes 2
T17993 1592-1594 , denotes ,
T17994 1594-1595 CD denotes 5
T17995 1595-1597 , denotes ,
T17996 1597-1598 CD denotes 8
T17997 1598-1600 , denotes ,
T17998 1600-1601 CD denotes 9
T17999 1601-1603 , denotes ,
T18000 1603-1605 CD denotes 11
T18001 1606-1609 CC denotes and
T18002 1610-1612 CD denotes 17
T18003 1612-1613 : denotes ;
T17988 1614-1619 NN denotes Table
T18004 1620-1621 CD denotes 1
T18005 1622-1625 CC denotes and
T18006 1626-1636 JJ denotes Additional
T18007 1637-1641 NN denotes File
T18008 1642-1643 CD denotes 1
T18009 1643-1644 -RRB- denotes )
T18010 1644-1646 , denotes ,
T18011 1646-1654 VBG denotes ensuring
T18012 1655-1658 DT denotes the
T18013 1659-1666 NN denotes absence
T18014 1667-1669 IN denotes of
T18015 1670-1674 NN denotes CAST
T18016 1675-1682 NNS denotes alleles
T18017 1683-1685 IN denotes at
T18018 1686-1690 DT denotes each
T18019 1691-1693 IN denotes of
T18020 1694-1699 DT denotes these
T18021 1700-1703 NN denotes QTL
T18022 1703-1704 . denotes .
T18023 1704-1863 sentence denotes This approach, termed "QTL-Marker-Assisted Counter Selection" or QMACS, has been previously used to characterize QTL for hypnotic sensitivity to ethanol [31].
T18024 1705-1709 DT denotes This
T18025 1710-1718 NN denotes approach
T18027 1718-1720 , denotes ,
T18028 1720-1726 VBN denotes termed
T18029 1727-1728 `` denotes "
T18030 1728-1731 NN denotes QTL
T18032 1731-1732 HYPH denotes -
T18031 1732-1738 NN denotes Marker
T18034 1738-1739 HYPH denotes -
T18033 1739-1747 VBN denotes Assisted
T18036 1748-1755 NN denotes Counter
T18035 1756-1765 NN denotes Selection
T18037 1765-1766 '' denotes "
T18038 1767-1769 CC denotes or
T18039 1770-1775 NN denotes QMACS
T18040 1775-1777 , denotes ,
T18041 1777-1780 VBZ denotes has
T18042 1781-1785 VBN denotes been
T18043 1786-1796 RB denotes previously
T18026 1797-1801 VBN denotes used
T18044 1802-1804 TO denotes to
T18045 1805-1817 VB denotes characterize
T18046 1818-1821 NN denotes QTL
T18047 1822-1825 IN denotes for
T18048 1826-1834 JJ denotes hypnotic
T18049 1835-1846 NN denotes sensitivity
T18050 1847-1849 IN denotes to
T18051 1850-1857 NN denotes ethanol
T18052 1858-1859 -LRB- denotes [
T18053 1859-1861 CD denotes 31
T18054 1861-1862 -RRB- denotes ]
T18055 1862-1863 . denotes .
T18056 1863-1941 sentence denotes In that study, only markers flanking QTL were typed, not genome-wide markers.
T18057 1864-1866 IN denotes In
T18059 1867-1871 DT denotes that
T18060 1872-1877 NN denotes study
T18061 1877-1879 , denotes ,
T18062 1879-1883 RB denotes only
T18063 1884-1891 NNS denotes markers
T18064 1892-1900 VBG denotes flanking
T18065 1901-1904 NN denotes QTL
T18066 1905-1909 VBD denotes were
T18058 1910-1915 VBN denotes typed
T18067 1915-1917 , denotes ,
T18068 1917-1920 CC denotes not
T18070 1921-1927 NN denotes genome
T18072 1927-1928 HYPH denotes -
T18071 1928-1932 JJ denotes wide
T18069 1933-1940 NNS denotes markers
T18073 1940-1941 . denotes .
T18074 1941-2146 sentence denotes In contrast, we selected not only against known QTL, we also screened for genome wide heterozygosity increasing the probability that effects observed are due to genetic variation within each donor region.
T18075 1942-1944 IN denotes In
T18077 1945-1953 NN denotes contrast
T18078 1953-1955 , denotes ,
T18079 1955-1957 PRP denotes we
T18080 1958-1966 VBD denotes selected
T18081 1967-1970 RB denotes not
T18082 1971-1975 RB denotes only
T18083 1976-1983 IN denotes against
T18084 1984-1989 VBN denotes known
T18085 1990-1993 NN denotes QTL
T18086 1993-1995 , denotes ,
T18087 1995-1997 PRP denotes we
T18088 1998-2002 RB denotes also
T18076 2003-2011 VBD denotes screened
T18089 2012-2015 IN denotes for
T18090 2016-2022 NN denotes genome
T18091 2023-2027 JJ denotes wide
T18092 2028-2042 NN denotes heterozygosity
T18093 2043-2053 VBG denotes increasing
T18094 2054-2057 DT denotes the
T18095 2058-2069 NN denotes probability
T18096 2070-2074 IN denotes that
T18098 2075-2082 NNS denotes effects
T18099 2083-2091 VBN denotes observed
T18097 2092-2095 VBP denotes are
T18100 2096-2099 IN denotes due
T18101 2100-2102 IN denotes to
T18102 2103-2110 JJ denotes genetic
T18103 2111-2120 NN denotes variation
T18104 2121-2127 IN denotes within
T18105 2128-2132 DT denotes each
T18107 2133-2138 NN denotes donor
T18106 2139-2145 NN denotes region
T18108 2145-2146 . denotes .
T18109 2146-2397 sentence denotes Although great effort was put forth to eliminate non-donor region direct genetic effects, other factors such as maternal genotype (maternal genotype for each congenic versus control dams differed) and environmental effects could confound our results.
T18110 2147-2155 IN denotes Although
T18112 2156-2161 JJ denotes great
T18113 2162-2168 NN denotes effort
T18114 2169-2172 VBD denotes was
T18111 2173-2176 VBN denotes put
T18116 2177-2182 RP denotes forth
T18117 2183-2185 TO denotes to
T18118 2186-2195 VB denotes eliminate
T18119 2196-2205 JJ denotes non-donor
T18120 2206-2212 NN denotes region
T18122 2213-2219 JJ denotes direct
T18123 2220-2227 JJ denotes genetic
T18121 2228-2235 NNS denotes effects
T18124 2235-2237 , denotes ,
T18125 2237-2242 JJ denotes other
T18126 2243-2250 NNS denotes factors
T18127 2251-2255 JJ denotes such
T18128 2256-2258 IN denotes as
T18129 2259-2267 JJ denotes maternal
T18130 2268-2276 NN denotes genotype
T18131 2277-2278 -LRB- denotes (
T18133 2278-2286 JJ denotes maternal
T18134 2287-2295 NN denotes genotype
T18135 2296-2299 IN denotes for
T18136 2300-2304 DT denotes each
T18137 2305-2313 JJ denotes congenic
T18138 2314-2320 CC denotes versus
T18139 2321-2328 NN denotes control
T18140 2329-2333 NNS denotes dams
T18132 2334-2342 VBD denotes differed
T18141 2342-2343 -RRB- denotes )
T18142 2344-2347 CC denotes and
T18143 2348-2361 JJ denotes environmental
T18144 2362-2369 NNS denotes effects
T18145 2370-2375 MD denotes could
T18115 2376-2384 VB denotes confound
T18146 2385-2388 PRP$ denotes our
T18147 2389-2396 NNS denotes results
T18148 2396-2397 . denotes .
T18149 2397-2566 sentence denotes Maternal genotype effects on growth and obesity have been observed in a number of mouse crosses [8,32-35] and their existence in the current cross cannot be discounted.
T18150 2398-2406 JJ denotes Maternal
T18151 2407-2415 NN denotes genotype
T18152 2416-2423 NNS denotes effects
T18154 2424-2426 IN denotes on
T18155 2427-2433 NN denotes growth
T18156 2434-2437 CC denotes and
T18157 2438-2445 NN denotes obesity
T18158 2446-2450 VBP denotes have
T18159 2451-2455 VBN denotes been
T18153 2456-2464 VBN denotes observed
T18160 2465-2467 IN denotes in
T18161 2468-2469 DT denotes a
T18162 2470-2476 NN denotes number
T18163 2477-2479 IN denotes of
T18164 2480-2485 NN denotes mouse
T18165 2486-2493 NNS denotes crosses
T18166 2494-2495 -LRB- denotes [
T18167 2495-2496 CD denotes 8
T18168 2496-2497 , denotes ,
T18169 2497-2499 CD denotes 32
T18170 2499-2500 SYM denotes -
T18171 2500-2502 CD denotes 35
T18172 2502-2503 -RRB- denotes ]
T18173 2504-2507 CC denotes and
T18174 2508-2513 PRP$ denotes their
T18175 2514-2523 NN denotes existence
T18177 2524-2526 IN denotes in
T18178 2527-2530 DT denotes the
T18180 2531-2538 JJ denotes current
T18179 2539-2544 NN denotes cross
T18181 2545-2548 MD denotes can
T18182 2548-2551 RB denotes not
T18183 2552-2554 VB denotes be
T18176 2555-2565 VBN denotes discounted
T18184 2565-2566 . denotes .
T18185 2566-2695 sentence denotes However, our congenics provide the ideal foundation genomic resource to test for the influence of any of these possible effects.
T18186 2567-2574 RB denotes However
T18188 2574-2576 , denotes ,
T18189 2576-2579 PRP$ denotes our
T18190 2580-2589 NNS denotes congenics
T18187 2590-2597 VBP denotes provide
T18191 2598-2601 DT denotes the
T18193 2602-2607 JJ denotes ideal
T18194 2608-2618 NN denotes foundation
T18195 2619-2626 JJ denotes genomic
T18192 2627-2635 NN denotes resource
T18196 2636-2638 TO denotes to
T18197 2639-2643 VB denotes test
T18198 2644-2647 IN denotes for
T18199 2648-2651 DT denotes the
T18200 2652-2661 NN denotes influence
T18201 2662-2664 IN denotes of
T18202 2665-2668 DT denotes any
T18203 2669-2671 IN denotes of
T18204 2672-2677 DT denotes these
T18206 2678-2686 JJ denotes possible
T18205 2687-2694 NNS denotes effects
T18207 2694-2695 . denotes .
T18208 2695-2884 sentence denotes Future fine mapping experiments can be designed to randomize the influences of any contaminating donor alleles and environmental differences, as well as test for maternal genotype effects.
T18209 2696-2702 JJ denotes Future
T18211 2703-2707 JJ denotes fine
T18212 2708-2715 NN denotes mapping
T18210 2716-2727 NNS denotes experiments
T18214 2728-2731 MD denotes can
T18215 2732-2734 VB denotes be
T18213 2735-2743 VBN denotes designed
T18216 2744-2746 TO denotes to
T18217 2747-2756 VB denotes randomize
T18218 2757-2760 DT denotes the
T18219 2761-2771 NNS denotes influences
T18220 2772-2774 IN denotes of
T18221 2775-2778 DT denotes any
T18223 2779-2792 VBG denotes contaminating
T18224 2793-2798 NN denotes donor
T18222 2799-2806 NNS denotes alleles
T18225 2807-2810 CC denotes and
T18226 2811-2824 JJ denotes environmental
T18227 2825-2836 NNS denotes differences
T18228 2836-2838 , denotes ,
T18229 2838-2840 RB denotes as
T18231 2841-2845 RB denotes well
T18230 2846-2848 IN denotes as
T18232 2849-2853 VB denotes test
T18233 2854-2857 IN denotes for
T18234 2858-2866 JJ denotes maternal
T18235 2867-2875 NN denotes genotype
T18236 2876-2883 NNS denotes effects
T18237 2883-2884 . denotes .
T18238 2884-2930 sentence denotes MMU2 is a hotspot for growth and obesity QTL.
T18239 2885-2889 NN denotes MMU2
T18240 2890-2892 VBZ denotes is
T18241 2893-2894 DT denotes a
T18242 2895-2902 NN denotes hotspot
T18243 2903-2906 IN denotes for
T18244 2907-2913 NN denotes growth
T18246 2914-2917 CC denotes and
T18247 2918-2925 NN denotes obesity
T18245 2926-2929 NN denotes QTL
T18248 2929-2930 . denotes .
T18249 2930-2993 sentence denotes Over 30 QTL have been identified in various experiments [1,2].
T18250 2931-2935 IN denotes Over
T18251 2936-2938 CD denotes 30
T18252 2939-2942 NN denotes QTL
T18254 2943-2947 VBP denotes have
T18255 2948-2952 VBN denotes been
T18253 2953-2963 VBN denotes identified
T18256 2964-2966 IN denotes in
T18257 2967-2974 JJ denotes various
T18258 2975-2986 NNS denotes experiments
T18259 2987-2988 -LRB- denotes [
T18261 2988-2989 CD denotes 1
T18262 2989-2990 , denotes ,
T18260 2990-2991 CD denotes 2
T18263 2991-2992 -RRB- denotes ]
T18264 2992-2993 . denotes .
T18265 2993-3112 sentence denotes Several previously reported or novel MMU2 QTL have been isolated and characterized using congenic strains [7,9-11,36].
T18266 2994-3001 JJ denotes Several
T18268 3002-3012 RB denotes previously
T18269 3013-3021 VBN denotes reported
T18270 3022-3024 CC denotes or
T18271 3025-3030 JJ denotes novel
T18272 3031-3035 NN denotes MMU2
T18267 3036-3039 NN denotes QTL
T18274 3040-3044 VBP denotes have
T18275 3045-3049 VBN denotes been
T18273 3050-3058 VBN denotes isolated
T18276 3059-3062 CC denotes and
T18277 3063-3076 VBN denotes characterized
T18278 3077-3082 VBG denotes using
T18279 3083-3091 JJ denotes congenic
T18280 3092-3099 NNS denotes strains
T18281 3100-3101 -LRB- denotes [
T18282 3101-3102 CD denotes 7
T18283 3102-3103 , denotes ,
T18284 3103-3104 CD denotes 9
T18285 3104-3105 SYM denotes -
T18286 3105-3107 CD denotes 11
T18287 3107-3108 , denotes ,
T18288 3108-3110 CD denotes 36
T18289 3110-3111 -RRB- denotes ]
T18290 3111-3112 . denotes .
T18291 3112-3235 sentence denotes Our findings are no different and indicate that MMU2 is highly complex with regards to genes affecting growth and obesity.
T18292 3113-3116 PRP$ denotes Our
T18293 3117-3125 NNS denotes findings
T18294 3126-3129 VBP denotes are
T18295 3130-3132 DT denotes no
T18296 3133-3142 JJ denotes different
T18297 3143-3146 CC denotes and
T18298 3147-3155 VBP denotes indicate
T18299 3156-3160 IN denotes that
T18301 3161-3165 NN denotes MMU2
T18300 3166-3168 VBZ denotes is
T18302 3169-3175 RB denotes highly
T18303 3176-3183 JJ denotes complex
T18304 3184-3188 IN denotes with
T18305 3189-3196 NNS denotes regards
T18306 3197-3199 IN denotes to
T18307 3200-3205 NNS denotes genes
T18308 3206-3215 VBG denotes affecting
T18309 3216-3222 NN denotes growth
T18310 3223-3226 CC denotes and
T18311 3227-3234 NN denotes obesity
T18312 3234-3235 . denotes .
T18313 3235-3357 sentence denotes The overlapping nature of our MMU2 strains allowed us to parse the chromosome into five regions (Regions I–V) (Figure 2).
T18314 3236-3239 DT denotes The
T18316 3240-3251 VBG denotes overlapping
T18315 3252-3258 NN denotes nature
T18318 3259-3261 IN denotes of
T18319 3262-3265 PRP$ denotes our
T18321 3266-3270 NN denotes MMU2
T18320 3271-3278 NNS denotes strains
T18317 3279-3286 VBD denotes allowed
T18322 3287-3289 PRP denotes us
T18324 3290-3292 TO denotes to
T18323 3293-3298 VB denotes parse
T18325 3299-3302 DT denotes the
T18326 3303-3313 NN denotes chromosome
T18327 3314-3318 IN denotes into
T18328 3319-3323 CD denotes five
T18329 3324-3331 NNS denotes regions
T18330 3332-3333 -LRB- denotes (
T18331 3333-3340 NNS denotes Regions
T18332 3341-3342 CD denotes I
T18333 3342-3343 SYM denotes –
T18334 3343-3344 CD denotes V
T18335 3344-3345 -RRB- denotes )
T18336 3346-3347 -LRB- denotes (
T18337 3347-3353 NN denotes Figure
T18338 3354-3355 CD denotes 2
T18339 3355-3356 -RRB- denotes )
T18340 3356-3357 . denotes .
T18341 3357-3447 sentence denotes The data support the presence of at least one QTL in each of the five regions (Figure 2).
T18342 3358-3361 DT denotes The
T18343 3362-3366 NNS denotes data
T18344 3367-3374 VBP denotes support
T18345 3375-3378 DT denotes the
T18346 3379-3387 NN denotes presence
T18347 3388-3390 IN denotes of
T18348 3391-3393 RB denotes at
T18350 3394-3399 RBS denotes least
T18349 3400-3403 CD denotes one
T18351 3404-3407 NN denotes QTL
T18352 3408-3410 IN denotes in
T18353 3411-3415 DT denotes each
T18354 3416-3418 IN denotes of
T18355 3419-3422 DT denotes the
T18357 3423-3427 CD denotes five
T18356 3428-3435 NNS denotes regions
T18358 3436-3437 -LRB- denotes (
T18359 3437-3443 NN denotes Figure
T18360 3444-3445 CD denotes 2
T18361 3445-3446 -RRB- denotes )
T18362 3446-3447 . denotes .
T18363 3447-3541 sentence denotes Each of the five pleiotropically impact both growth and obesity, although to varying degrees.
T18364 3448-3452 DT denotes Each
T18366 3453-3455 IN denotes of
T18367 3456-3459 DT denotes the
T18368 3460-3464 CD denotes five
T18369 3465-3480 RB denotes pleiotropically
T18365 3481-3487 VBP denotes impact
T18370 3488-3492 CC denotes both
T18371 3493-3499 NN denotes growth
T18372 3500-3503 CC denotes and
T18373 3504-3511 NN denotes obesity
T18374 3511-3513 , denotes ,
T18375 3513-3521 IN denotes although
T18376 3522-3524 IN denotes to
T18377 3525-3532 VBG denotes varying
T18378 3533-3540 NNS denotes degrees
T18379 3540-3541 . denotes .
T18380 3541-3716 sentence denotes In addition to the large number of MMU2 QTL, the presence of hg adds complexity by either eliciting interactions with the same QTL or by inducing the expression of novel QTL.
T18381 3542-3544 IN denotes In
T18383 3545-3553 NN denotes addition
T18384 3554-3556 IN denotes to
T18385 3557-3560 DT denotes the
T18387 3561-3566 JJ denotes large
T18386 3567-3573 NN denotes number
T18388 3574-3576 IN denotes of
T18389 3577-3581 NN denotes MMU2
T18390 3582-3585 NN denotes QTL
T18391 3585-3587 , denotes ,
T18392 3587-3590 DT denotes the
T18393 3591-3599 NN denotes presence
T18394 3600-3602 IN denotes of
T18395 3603-3605 NN denotes hg
T18382 3606-3610 VBZ denotes adds
T18396 3611-3621 NN denotes complexity
T18397 3622-3624 IN denotes by
T18398 3625-3631 CC denotes either
T18399 3632-3641 VBG denotes eliciting
T18400 3642-3654 NNS denotes interactions
T18401 3655-3659 IN denotes with
T18402 3660-3663 DT denotes the
T18404 3664-3668 JJ denotes same
T18403 3669-3672 NN denotes QTL
T18405 3673-3675 CC denotes or
T18406 3676-3678 IN denotes by
T18407 3679-3687 VBG denotes inducing
T18408 3688-3691 DT denotes the
T18409 3692-3702 NN denotes expression
T18410 3703-3705 IN denotes of
T18411 3706-3711 JJ denotes novel
T18412 3712-3715 NN denotes QTL
T18413 3715-3716 . denotes .
T18414 3716-3843 sentence denotes The 2P unique region (Region I) contains an hg modifier with large effects on growth and smaller effects on obesity (Table 3).
T18415 3717-3720 DT denotes The
T18417 3721-3723 NN denotes 2P
T18418 3724-3730 JJ denotes unique
T18416 3731-3737 NN denotes region
T18420 3738-3739 -LRB- denotes (
T18421 3739-3745 NN denotes Region
T18422 3746-3747 CD denotes I
T18423 3747-3748 -RRB- denotes )
T18419 3749-3757 VBZ denotes contains
T18424 3758-3760 DT denotes an
T18426 3761-3763 NN denotes hg
T18425 3764-3772 NN denotes modifier
T18427 3773-3777 IN denotes with
T18428 3778-3783 JJ denotes large
T18429 3784-3791 NNS denotes effects
T18430 3792-3794 IN denotes on
T18431 3795-3801 NN denotes growth
T18432 3802-3805 CC denotes and
T18433 3806-3813 JJR denotes smaller
T18434 3814-3821 NNS denotes effects
T18435 3822-3824 IN denotes on
T18436 3825-3832 NN denotes obesity
T18437 3833-3834 -LRB- denotes (
T18438 3834-3839 NN denotes Table
T18439 3840-3841 CD denotes 3
T18440 3841-3842 -RRB- denotes )
T18441 3842-3843 . denotes .
T18442 3843-3938 sentence denotes In contrast, interactions between 2PM/2M QTL and hg primarily affect fat deposition (Table 3).
T18443 3844-3846 IN denotes In
T18445 3847-3855 NN denotes contrast
T18446 3855-3857 , denotes ,
T18447 3857-3869 NNS denotes interactions
T18448 3870-3877 IN denotes between
T18449 3878-3881 NN denotes 2PM
T18451 3881-3882 HYPH denotes /
T18450 3882-3884 NN denotes 2M
T18452 3885-3888 NN denotes QTL
T18453 3889-3892 CC denotes and
T18454 3893-3895 NN denotes hg
T18455 3896-3905 RB denotes primarily
T18444 3906-3912 VBP denotes affect
T18456 3913-3916 NN denotes fat
T18457 3917-3927 NN denotes deposition
T18458 3928-3929 -LRB- denotes (
T18459 3929-3934 NN denotes Table
T18460 3935-3936 CD denotes 3
T18461 3936-3937 -RRB- denotes )
T18462 3937-3938 . denotes .
T18463 3938-4068 sentence denotes As illustrated in Figure 4 the 2M donor region exhibits strong sex effects on the rate of lipid storage, dependent on background.
T18464 3939-3941 IN denotes As
T18465 3942-3953 VBN denotes illustrated
T18467 3954-3956 IN denotes in
T18468 3957-3963 NN denotes Figure
T18469 3964-3965 CD denotes 4
T18470 3966-3969 DT denotes the
T18472 3970-3972 NN denotes 2M
T18473 3973-3978 NN denotes donor
T18471 3979-3985 NN denotes region
T18466 3986-3994 VBZ denotes exhibits
T18474 3995-4001 JJ denotes strong
T18476 4002-4005 NN denotes sex
T18475 4006-4013 NNS denotes effects
T18477 4014-4016 IN denotes on
T18478 4017-4020 DT denotes the
T18479 4021-4025 NN denotes rate
T18480 4026-4028 IN denotes of
T18481 4029-4034 NN denotes lipid
T18482 4035-4042 NN denotes storage
T18483 4042-4044 , denotes ,
T18484 4044-4053 JJ denotes dependent
T18485 4054-4056 IN denotes on
T18486 4057-4067 NN denotes background
T18487 4067-4068 . denotes .
T18488 4068-4166 sentence denotes In control mice, HGC females have a higher AI than males, while the opposite is seen in B6C mice.
T18489 4069-4071 IN denotes In
T18491 4072-4079 NN denotes control
T18492 4080-4084 NNS denotes mice
T18493 4084-4086 , denotes ,
T18494 4086-4089 NN denotes HGC
T18495 4090-4097 NNS denotes females
T18490 4098-4102 VBP denotes have
T18496 4103-4104 DT denotes a
T18498 4105-4111 JJR denotes higher
T18497 4112-4114 NN denotes AI
T18499 4115-4119 IN denotes than
T18500 4120-4125 NNS denotes males
T18501 4125-4127 , denotes ,
T18502 4127-4132 IN denotes while
T18504 4133-4136 DT denotes the
T18505 4137-4145 NN denotes opposite
T18506 4146-4148 VBZ denotes is
T18503 4149-4153 VBN denotes seen
T18507 4154-4156 IN denotes in
T18508 4157-4160 NN denotes B6C
T18509 4161-4165 NNS denotes mice
T18510 4165-4166 . denotes .
T18511 4166-4272 sentence denotes Interestingly, the 2M hg modifier QTL abolished the hg induced sexual dimorphism in adiposity (Figure 4).
T18512 4167-4180 RB denotes Interestingly
T18514 4180-4182 , denotes ,
T18515 4182-4185 DT denotes the
T18517 4186-4188 NN denotes 2M
T18518 4189-4191 NN denotes hg
T18519 4192-4200 NN denotes modifier
T18516 4201-4204 NN denotes QTL
T18513 4205-4214 VBD denotes abolished
T18520 4215-4218 DT denotes the
T18522 4219-4221 NN denotes hg
T18523 4222-4229 VBN denotes induced
T18524 4230-4236 JJ denotes sexual
T18521 4237-4247 NN denotes dimorphism
T18525 4248-4250 IN denotes in
T18526 4251-4260 NN denotes adiposity
T18527 4261-4262 -LRB- denotes (
T18528 4262-4268 NN denotes Figure
T18529 4269-4270 CD denotes 4
T18530 4270-4271 -RRB- denotes )
T18531 4271-4272 . denotes .
T18532 4272-4437 sentence denotes Although these results provide insight into the nature of hg modifier QTL, it should be noted, that the actual number and precise location of loci is still unclear.
T18533 4273-4281 IN denotes Although
T18535 4282-4287 DT denotes these
T18536 4288-4295 NNS denotes results
T18534 4296-4303 VBP denotes provide
T18538 4304-4311 NN denotes insight
T18539 4312-4316 IN denotes into
T18540 4317-4320 DT denotes the
T18541 4321-4327 NN denotes nature
T18542 4328-4330 IN denotes of
T18543 4331-4333 NN denotes hg
T18544 4334-4342 NN denotes modifier
T18545 4343-4346 NN denotes QTL
T18546 4346-4348 , denotes ,
T18547 4348-4350 PRP denotes it
T18548 4351-4357 MD denotes should
T18549 4358-4360 VB denotes be
T18537 4361-4366 VBN denotes noted
T18550 4366-4368 , denotes ,
T18551 4368-4372 IN denotes that
T18553 4373-4376 DT denotes the
T18555 4377-4383 JJ denotes actual
T18554 4384-4390 NN denotes number
T18556 4391-4394 CC denotes and
T18557 4395-4402 JJ denotes precise
T18558 4403-4411 NN denotes location
T18559 4412-4414 IN denotes of
T18560 4415-4419 NNS denotes loci
T18552 4420-4422 VBZ denotes is
T18561 4423-4428 RB denotes still
T18562 4429-4436 JJ denotes unclear
T18563 4436-4437 . denotes .
T18564 4437-4527 sentence denotes In addition to MMU2, three other congenics (HG9, HG11 and HG17) captured hg modifier QTL.
T18565 4438-4440 IN denotes In
T18567 4441-4449 NN denotes addition
T18568 4450-4452 IN denotes to
T18569 4453-4457 NN denotes MMU2
T18570 4457-4459 , denotes ,
T18571 4459-4464 CD denotes three
T18573 4465-4470 JJ denotes other
T18572 4471-4480 NNS denotes congenics
T18574 4481-4482 -LRB- denotes (
T18575 4482-4485 NN denotes HG9
T18576 4485-4487 , denotes ,
T18577 4487-4491 NN denotes HG11
T18578 4492-4495 CC denotes and
T18579 4496-4500 NN denotes HG17
T18580 4500-4501 -RRB- denotes )
T18566 4502-4510 VBD denotes captured
T18581 4511-4513 NN denotes hg
T18582 4514-4522 NN denotes modifier
T18583 4523-4526 NN denotes QTL
T18584 4526-4527 . denotes .
T18585 4527-4629 sentence denotes In classical terms, they are QTL which modify the expressivity of growth and obesity in HG mice [18].
T18586 4528-4530 IN denotes In
T18588 4531-4540 JJ denotes classical
T18589 4541-4546 NNS denotes terms
T18590 4546-4548 , denotes ,
T18591 4548-4552 PRP denotes they
T18587 4553-4556 VBP denotes are
T18592 4557-4560 NN denotes QTL
T18593 4561-4566 WDT denotes which
T18594 4567-4573 VBP denotes modify
T18595 4574-4577 DT denotes the
T18596 4578-4590 NN denotes expressivity
T18597 4591-4593 IN denotes of
T18598 4594-4600 NN denotes growth
T18599 4601-4604 CC denotes and
T18600 4605-4612 NN denotes obesity
T18601 4613-4615 IN denotes in
T18602 4616-4618 NN denotes HG
T18603 4619-4623 NNS denotes mice
T18604 4624-4625 -LRB- denotes [
T18605 4625-4627 CD denotes 18
T18606 4627-4628 -RRB- denotes ]
T18607 4628-4629 . denotes .
T18608 4629-4714 sentence denotes These QTL are novel since they represent epistasis between hg and the modifier gene.
T18609 4630-4635 DT denotes These
T18610 4636-4639 NN denotes QTL
T18611 4640-4643 VBP denotes are
T18612 4644-4649 JJ denotes novel
T18613 4650-4655 IN denotes since
T18615 4656-4660 PRP denotes they
T18614 4661-4670 VBP denotes represent
T18616 4671-4680 NN denotes epistasis
T18617 4681-4688 IN denotes between
T18618 4689-4691 NN denotes hg
T18619 4692-4695 CC denotes and
T18620 4696-4699 DT denotes the
T18622 4700-4708 NN denotes modifier
T18621 4709-4713 NN denotes gene
T18623 4713-4714 . denotes .
T18624 4714-4807 sentence denotes QTL-hg epistasis implies that Socs2 and the hg modifiers are in the same biological pathway.
T18625 4715-4718 NN denotes QTL
T18627 4718-4719 HYPH denotes -
T18626 4719-4721 NN denotes hg
T18628 4722-4731 NN denotes epistasis
T18629 4732-4739 VBZ denotes implies
T18630 4740-4744 IN denotes that
T18632 4745-4750 NN denotes Socs2
T18633 4751-4754 CC denotes and
T18634 4755-4758 DT denotes the
T18636 4759-4761 NN denotes hg
T18635 4762-4771 NNS denotes modifiers
T18631 4772-4775 VBP denotes are
T18637 4776-4778 IN denotes in
T18638 4779-4782 DT denotes the
T18640 4783-4787 JJ denotes same
T18641 4788-4798 JJ denotes biological
T18639 4799-4806 NN denotes pathway
T18642 4806-4807 . denotes .
T18643 4807-4949 sentence denotes Therefore, these QTL are likely due to polymorphism in genes interacting with Gh, responsive to Gh or which in some way modulate Gh function.
T18644 4808-4817 RB denotes Therefore
T18646 4817-4819 , denotes ,
T18647 4819-4824 DT denotes these
T18648 4825-4828 NN denotes QTL
T18645 4829-4832 VBP denotes are
T18649 4833-4839 RB denotes likely
T18650 4840-4843 IN denotes due
T18651 4844-4846 IN denotes to
T18652 4847-4859 NN denotes polymorphism
T18653 4860-4862 IN denotes in
T18654 4863-4868 NNS denotes genes
T18655 4869-4880 VBG denotes interacting
T18656 4881-4885 IN denotes with
T18657 4886-4888 NN denotes Gh
T18658 4888-4890 , denotes ,
T18659 4890-4900 JJ denotes responsive
T18660 4901-4903 IN denotes to
T18661 4904-4906 NN denotes Gh
T18662 4907-4909 CC denotes or
T18663 4910-4915 WDT denotes which
T18665 4916-4918 IN denotes in
T18666 4919-4923 DT denotes some
T18667 4924-4927 NN denotes way
T18664 4928-4936 VBP denotes modulate
T18668 4937-4939 NN denotes Gh
T18669 4940-4948 NN denotes function
T18670 4948-4949 . denotes .
T18671 4949-5051 sentence denotes This information will significantly aid QTL cloning by providing another filter to screen candidates.
T18672 4950-4954 DT denotes This
T18673 4955-4966 NN denotes information
T18675 4967-4971 MD denotes will
T18676 4972-4985 RB denotes significantly
T18674 4986-4989 VB denotes aid
T18677 4990-4993 NN denotes QTL
T18678 4994-5001 NN denotes cloning
T18679 5002-5004 IN denotes by
T18680 5005-5014 VBG denotes providing
T18681 5015-5022 DT denotes another
T18682 5023-5029 NN denotes filter
T18683 5030-5032 TO denotes to
T18684 5033-5039 VB denotes screen
T18685 5040-5050 NNS denotes candidates
T18686 5050-5051 . denotes .
T18687 5051-5222 sentence denotes Cloning these QTL has major implications to improve our understanding of Gh and its regulation of growth and adiposity and in the administration of human Gh therapeutics.
T18688 5052-5059 VBG denotes Cloning
T18690 5060-5065 DT denotes these
T18689 5066-5069 NN denotes QTL
T18691 5070-5073 VBZ denotes has
T18692 5074-5079 JJ denotes major
T18693 5080-5092 NNS denotes implications
T18694 5093-5095 TO denotes to
T18695 5096-5103 VB denotes improve
T18696 5104-5107 PRP$ denotes our
T18697 5108-5121 NN denotes understanding
T18698 5122-5124 IN denotes of
T18699 5125-5127 NN denotes Gh
T18700 5128-5131 CC denotes and
T18701 5132-5135 PRP$ denotes its
T18702 5136-5146 NN denotes regulation
T18703 5147-5149 IN denotes of
T18704 5150-5156 NN denotes growth
T18705 5157-5160 CC denotes and
T18706 5161-5170 NN denotes adiposity
T18707 5171-5174 CC denotes and
T18708 5175-5177 IN denotes in
T18709 5178-5181 DT denotes the
T18710 5182-5196 NN denotes administration
T18711 5197-5199 IN denotes of
T18712 5200-5205 JJ denotes human
T18713 5206-5208 NN denotes Gh
T18714 5209-5221 NNS denotes therapeutics
T18715 5221-5222 . denotes .
T18716 5222-5276 sentence denotes HG1 mice displayed differences only in growth traits.
T18717 5223-5226 NN denotes HG1
T18718 5227-5231 NNS denotes mice
T18719 5232-5241 VBD denotes displayed
T18720 5242-5253 NNS denotes differences
T18721 5254-5258 RB denotes only
T18722 5259-5261 IN denotes in
T18723 5262-5268 NN denotes growth
T18724 5269-5275 NNS denotes traits
T18725 5275-5276 . denotes .
T18726 5276-5515 sentence denotes Originally, Q1Ucd1 had small effects and these results illustrate the power of congenic strain analysis to isolate small effect QTL, although it is likely this QTL represents the lower boundary of detection using only 20–30 congenic mice.
T18727 5277-5287 RB denotes Originally
T18729 5287-5289 , denotes ,
T18730 5289-5295 NN denotes Q1Ucd1
T18728 5296-5299 VBD denotes had
T18731 5300-5305 JJ denotes small
T18732 5306-5313 NNS denotes effects
T18733 5314-5317 CC denotes and
T18734 5318-5323 DT denotes these
T18735 5324-5331 NNS denotes results
T18736 5332-5342 VBP denotes illustrate
T18737 5343-5346 DT denotes the
T18738 5347-5352 NN denotes power
T18739 5353-5355 IN denotes of
T18740 5356-5364 JJ denotes congenic
T18741 5365-5371 NN denotes strain
T18742 5372-5380 NN denotes analysis
T18743 5381-5383 TO denotes to
T18744 5384-5391 VB denotes isolate
T18745 5392-5397 JJ denotes small
T18746 5398-5404 NN denotes effect
T18747 5405-5408 NN denotes QTL
T18748 5408-5410 , denotes ,
T18749 5410-5418 IN denotes although
T18751 5419-5421 PRP denotes it
T18750 5422-5424 VBZ denotes is
T18752 5425-5431 JJ denotes likely
T18753 5432-5436 DT denotes this
T18754 5437-5440 NN denotes QTL
T18755 5441-5451 VBZ denotes represents
T18756 5452-5455 DT denotes the
T18758 5456-5461 JJR denotes lower
T18757 5462-5470 NN denotes boundary
T18759 5471-5473 IN denotes of
T18760 5474-5483 NN denotes detection
T18761 5484-5489 VBG denotes using
T18762 5490-5494 RB denotes only
T18764 5495-5497 CD denotes 20
T18765 5497-5498 SYM denotes –
T18763 5498-5500 CD denotes 30
T18767 5501-5509 JJ denotes congenic
T18766 5510-5514 NNS denotes mice
T18768 5514-5515 . denotes .
T18769 5515-5658 sentence denotes The most notable candidate genes located within the HG1 interval are the signal transducer and activator of transcription 1 (Stat1) and Stat4.
T18770 5516-5519 DT denotes The
T18772 5520-5524 RBS denotes most
T18773 5525-5532 JJ denotes notable
T18774 5533-5542 NN denotes candidate
T18771 5543-5548 NNS denotes genes
T18776 5549-5556 VBN denotes located
T18777 5557-5563 IN denotes within
T18778 5564-5567 DT denotes the
T18780 5568-5571 NN denotes HG1
T18779 5572-5580 NN denotes interval
T18775 5581-5584 VBP denotes are
T18781 5585-5588 DT denotes the
T18783 5589-5595 NN denotes signal
T18782 5596-5606 NN denotes transducer
T18784 5607-5610 CC denotes and
T18785 5611-5620 NN denotes activator
T18786 5621-5623 IN denotes of
T18787 5624-5637 NN denotes transcription
T18788 5638-5639 CD denotes 1
T18789 5640-5641 -LRB- denotes (
T18790 5641-5646 NN denotes Stat1
T18791 5646-5647 -RRB- denotes )
T18792 5648-5651 CC denotes and
T18793 5652-5657 NN denotes Stat4
T18794 5657-5658 . denotes .
T18795 5658-5751 sentence denotes Two of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9.
T18796 5659-5662 CD denotes Two
T18798 5663-5665 IN denotes of
T18799 5666-5669 DT denotes the
T18800 5670-5679 NNS denotes congenics
T18797 5680-5683 VBD denotes had
T18801 5684-5689 JJ denotes major
T18802 5690-5701 NNS denotes alterations
T18803 5702-5704 IN denotes in
T18804 5705-5708 DT denotes the
T18805 5709-5719 NN denotes deposition
T18806 5720-5722 IN denotes of
T18807 5723-5730 NN denotes adipose
T18808 5731-5737 NN denotes tissue
T18809 5737-5739 , denotes ,
T18810 5739-5742 NN denotes HG8
T18811 5743-5746 CC denotes and
T18812 5747-5750 NN denotes HG9
T18813 5750-5751 . denotes .
T18814 5751-5791 sentence denotes The HG8 donor region promotes leanness.
T18815 5752-5755 DT denotes The
T18817 5756-5759 NN denotes HG8
T18818 5760-5765 NN denotes donor
T18816 5766-5772 NN denotes region
T18819 5773-5781 VBZ denotes promotes
T18820 5782-5790 NN denotes leanness
T18821 5790-5791 . denotes .
T18822 5791-5849 sentence denotes Congenic females displayed a reduction of over 25% in AI.
T18823 5792-5800 JJ denotes Congenic
T18824 5801-5808 NNS denotes females
T18825 5809-5818 VBD denotes displayed
T18826 5819-5820 DT denotes a
T18827 5821-5830 NN denotes reduction
T18828 5831-5833 IN denotes of
T18829 5834-5838 IN denotes over
T18830 5839-5841 CD denotes 25
T18831 5841-5842 NN denotes %
T18832 5843-5845 IN denotes in
T18833 5846-5848 NN denotes AI
T18834 5848-5849 . denotes .
T18835 5849-5902 sentence denotes In contrast, the HG9 strain is an obese mouse model.
T18836 5850-5852 IN denotes In
T18838 5853-5861 NN denotes contrast
T18839 5861-5863 , denotes ,
T18840 5863-5866 DT denotes the
T18842 5867-5870 NN denotes HG9
T18841 5871-5877 NN denotes strain
T18837 5878-5880 VBZ denotes is
T18843 5881-5883 DT denotes an
T18845 5884-5889 JJ denotes obese
T18846 5890-5895 NN denotes mouse
T18844 5896-5901 NN denotes model
T18847 5901-5902 . denotes .
T18848 5902-5945 sentence denotes The strain is quite novel for two reasons.
T18849 5903-5906 DT denotes The
T18850 5907-5913 NN denotes strain
T18851 5914-5916 VBZ denotes is
T18852 5917-5922 RB denotes quite
T18853 5923-5928 JJ denotes novel
T18854 5929-5932 IN denotes for
T18855 5933-5936 CD denotes two
T18856 5937-5944 NNS denotes reasons
T18857 5944-5945 . denotes .
T18858 5945-6036 sentence denotes First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males.
T18859 5946-5951 RB denotes First
T18861 5951-5953 , denotes ,
T18862 5953-5956 DT denotes the
T18864 5957-5963 NN denotes effect
T18863 5964-5968 NN denotes size
T18865 5969-5971 VBZ denotes is
T18866 5972-5977 JJ denotes large
T18867 5977-5978 : denotes ;
T18868 5979-5981 NN denotes AI
T18860 5982-5985 VBD denotes was
T18869 5986-5988 CD denotes 57
T18870 5988-5989 NN denotes %
T18871 5990-5996 JJR denotes higher
T18872 5997-5999 IN denotes in
T18873 6000-6003 NN denotes HG9
T18874 6004-6011 NNS denotes females
T18875 6012-6015 CC denotes and
T18876 6016-6018 CD denotes 30
T18877 6018-6019 NN denotes %
T18878 6020-6026 JJR denotes higher
T18879 6027-6029 IN denotes in
T18880 6030-6035 NNS denotes males
T18881 6035-6036 . denotes .
T18882 6036-6088 sentence denotes Secondly, it is dependent on hg for its expression.
T18883 6037-6045 RB denotes Secondly
T18885 6045-6047 , denotes ,
T18886 6047-6049 PRP denotes it
T18884 6050-6052 VBZ denotes is
T18887 6053-6062 JJ denotes dependent
T18888 6063-6065 IN denotes on
T18889 6066-6068 NN denotes hg
T18890 6069-6072 IN denotes for
T18891 6073-6076 PRP$ denotes its
T18892 6077-6087 NN denotes expression
T18893 6087-6088 . denotes .
T18894 6088-6276 sentence denotes The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh.
T18895 6089-6092 DT denotes The
T18897 6093-6096 NN denotes HG9
T18896 6097-6103 NN denotes strain
T18898 6104-6114 VBZ denotes represents
T18899 6115-6116 DT denotes a
T18901 6117-6122 JJ denotes major
T18902 6123-6132 NN denotes epistasis
T18904 6132-6133 HYPH denotes -
T18903 6133-6138 VBN denotes based
T18905 6139-6144 JJ denotes obese
T18906 6145-6150 NN denotes mouse
T18900 6151-6156 NN denotes model
T18907 6157-6160 CC denotes and
T18908 6161-6169 VBZ denotes promises
T18909 6170-6172 TO denotes to
T18910 6173-6176 VB denotes aid
T18911 6177-6179 IN denotes in
T18912 6180-6183 DT denotes the
T18913 6184-6197 NN denotes understanding
T18914 6198-6200 IN denotes of
T18915 6201-6208 NN denotes obesity
T18916 6209-6212 CC denotes and
T18917 6213-6225 RB denotes specifically
T18919 6226-6229 DT denotes the
T18918 6230-6240 NN denotes modulation
T18920 6241-6243 IN denotes of
T18921 6244-6251 NN denotes adipose
T18922 6252-6258 NN denotes tissue
T18923 6259-6269 NN denotes deposition
T18924 6270-6272 IN denotes by
T18925 6273-6275 NN denotes Gh
T18926 6275-6276 . denotes .
T18927 6276-6532 sentence denotes Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity.
T18928 6277-6284 NNS denotes Studies
T18929 6285-6288 VBP denotes are
T18930 6289-6298 RB denotes currently
T18931 6299-6307 JJ denotes underway
T18932 6308-6310 TO denotes to
T18933 6311-6319 VB denotes identify
T18934 6320-6323 DT denotes the
T18936 6324-6333 JJ denotes causative
T18935 6334-6342 NN denotes mutation
T18937 6343-6346 CC denotes and
T18938 6347-6349 TO denotes to
T18939 6350-6362 VB denotes characterize
T18940 6363-6366 DT denotes the
T18941 6367-6374 NNS denotes effects
T18942 6375-6377 IN denotes of
T18943 6378-6381 NN denotes age
T18944 6382-6385 CC denotes and
T18945 6386-6390 NN denotes diet
T18946 6391-6393 IN denotes on
T18947 6394-6401 NN denotes obesity
T18948 6402-6404 IN denotes in
T18949 6405-6409 DT denotes this
T18950 6410-6416 NN denotes strain
T18951 6417-6419 RB denotes as
T18953 6420-6424 RB denotes well
T18952 6425-6427 IN denotes as
T18954 6428-6435 NN denotes testing
T18955 6436-6439 IN denotes for
T18956 6440-6445 JJ denotes other
T18958 6446-6459 JJ denotes physiological
T18957 6460-6472 NNS denotes consequences
T18959 6473-6477 JJ denotes such
T18960 6478-6480 IN denotes as
T18961 6481-6492 NNS denotes alterations
T18962 6493-6495 IN denotes in
T18963 6496-6500 NN denotes food
T18964 6501-6507 NN denotes intake
T18965 6508-6511 CC denotes and
T18966 6512-6519 NN denotes insulin
T18967 6520-6531 NN denotes sensitivity
T18968 6531-6532 . denotes .
T18969 6532-6599 sentence denotes The HG11 strain is of particular interest for a number of reasons.
T18970 6533-6536 DT denotes The
T18972 6537-6541 NN denotes HG11
T18971 6542-6548 NN denotes strain
T18973 6549-6551 VBZ denotes is
T18974 6552-6554 IN denotes of
T18975 6555-6565 JJ denotes particular
T18976 6566-6574 NN denotes interest
T18977 6575-6578 IN denotes for
T18978 6579-6580 DT denotes a
T18979 6581-6587 NN denotes number
T18980 6588-6590 IN denotes of
T18981 6591-6598 NNS denotes reasons
T18982 6598-6599 . denotes .
T18983 6599-6701 sentence denotes First, HG11 congenic mice demonstrated significant strain by sex interactions for a number of traits.
T18984 6600-6605 RB denotes First
T18986 6605-6607 , denotes ,
T18987 6607-6611 NN denotes HG11
T18988 6612-6620 JJ denotes congenic
T18989 6621-6625 NNS denotes mice
T18985 6626-6638 VBD denotes demonstrated
T18990 6639-6650 JJ denotes significant
T18992 6651-6657 NN denotes strain
T18993 6658-6660 IN denotes by
T18994 6661-6664 NN denotes sex
T18991 6665-6677 NNS denotes interactions
T18995 6678-6681 IN denotes for
T18996 6682-6683 DT denotes a
T18997 6684-6690 NN denotes number
T18998 6691-6693 IN denotes of
T18999 6694-6700 NNS denotes traits
T19000 6700-6701 . denotes .
T19001 6701-6794 sentence denotes Males were generally larger, faster growing and longer and the converse was seen in females.
T19002 6702-6707 NNS denotes Males
T19003 6708-6712 VBD denotes were
T19004 6713-6722 RB denotes generally
T19005 6723-6729 JJR denotes larger
T19006 6729-6731 , denotes ,
T19007 6731-6737 JJR denotes faster
T19008 6738-6745 VBG denotes growing
T19009 6746-6749 CC denotes and
T19010 6750-6756 JJR denotes longer
T19011 6757-6760 CC denotes and
T19012 6761-6764 DT denotes the
T19013 6765-6773 NN denotes converse
T19015 6774-6777 VBD denotes was
T19014 6778-6782 VBN denotes seen
T19016 6783-6785 IN denotes in
T19017 6786-6793 NNS denotes females
T19018 6793-6794 . denotes .
T19019 6794-6956 sentence denotes The confounding effects of sex are likely the reason for the discrepancies between the congenic and genome scan results, where both sexes were analyzed together.
T19020 6795-6798 DT denotes The
T19022 6799-6810 VBG denotes confounding
T19021 6811-6818 NNS denotes effects
T19024 6819-6821 IN denotes of
T19025 6822-6825 NN denotes sex
T19023 6826-6829 VBP denotes are
T19026 6830-6836 RB denotes likely
T19027 6837-6840 DT denotes the
T19028 6841-6847 NN denotes reason
T19029 6848-6851 IN denotes for
T19030 6852-6855 DT denotes the
T19031 6856-6869 NNS denotes discrepancies
T19032 6870-6877 IN denotes between
T19033 6878-6881 DT denotes the
T19035 6882-6890 JJ denotes congenic
T19037 6891-6894 CC denotes and
T19036 6895-6901 NN denotes genome
T19038 6902-6906 NN denotes scan
T19034 6907-6914 NNS denotes results
T19039 6914-6916 , denotes ,
T19040 6916-6921 WRB denotes where
T19042 6922-6926 DT denotes both
T19043 6927-6932 NNS denotes sexes
T19044 6933-6937 VBD denotes were
T19041 6938-6946 VBN denotes analyzed
T19045 6947-6955 RB denotes together
T19046 6955-6956 . denotes .
T19047 6956-7127 sentence denotes Secondly, Carp2 was found to interact with hg and MMU11 is saturated with genes involved in the central Gh intracellular signaling pathway, such as Gh, Stat5b and Stat5a.
T19048 6957-6965 RB denotes Secondly
T19050 6965-6967 , denotes ,
T19051 6967-6972 NN denotes Carp2
T19052 6973-6976 VBD denotes was
T19049 6977-6982 VBN denotes found
T19053 6983-6985 TO denotes to
T19054 6986-6994 VB denotes interact
T19055 6995-6999 IN denotes with
T19056 7000-7002 NN denotes hg
T19057 7003-7006 CC denotes and
T19058 7007-7012 NN denotes MMU11
T19060 7013-7015 VBZ denotes is
T19059 7016-7025 VBN denotes saturated
T19061 7026-7030 IN denotes with
T19062 7031-7036 NNS denotes genes
T19063 7037-7045 VBN denotes involved
T19064 7046-7048 IN denotes in
T19065 7049-7052 DT denotes the
T19067 7053-7060 JJ denotes central
T19068 7061-7063 NN denotes Gh
T19069 7064-7077 JJ denotes intracellular
T19070 7078-7087 NN denotes signaling
T19066 7088-7095 NN denotes pathway
T19071 7095-7097 , denotes ,
T19072 7097-7101 JJ denotes such
T19073 7102-7104 IN denotes as
T19074 7105-7107 NN denotes Gh
T19075 7107-7109 , denotes ,
T19076 7109-7115 NN denotes Stat5b
T19077 7116-7119 CC denotes and
T19078 7120-7126 NN denotes Stat5a
T19079 7126-7127 . denotes .
T19080 7127-7253 sentence denotes Thirdly, MMU11 growth QTL overlapping HG11 have been identified in a number of crosses using different mouse strains [37-41].
T19081 7128-7135 RB denotes Thirdly
T19083 7135-7137 , denotes ,
T19084 7137-7142 NN denotes MMU11
T19086 7143-7149 NN denotes growth
T19085 7150-7153 NN denotes QTL
T19087 7154-7165 VBG denotes overlapping
T19088 7166-7170 NN denotes HG11
T19089 7171-7175 VBP denotes have
T19090 7176-7180 VBN denotes been
T19082 7181-7191 VBN denotes identified
T19091 7192-7194 IN denotes in
T19092 7195-7196 DT denotes a
T19093 7197-7203 NN denotes number
T19094 7204-7206 IN denotes of
T19095 7207-7214 NNS denotes crosses
T19096 7215-7220 VBG denotes using
T19097 7221-7230 JJ denotes different
T19099 7231-7236 NN denotes mouse
T19098 7237-7244 NNS denotes strains
T19100 7245-7246 -LRB- denotes [
T19101 7246-7248 CD denotes 37
T19102 7248-7249 SYM denotes -
T19103 7249-7251 CD denotes 41
T19104 7251-7252 -RRB- denotes ]
T19105 7252-7253 . denotes .
T19106 7253-7490 sentence denotes Given the well documented sexually dimorphic nature of Gh secretion and Gh induced gene expression [42,43], it is probable that the underlying mutation in the HG11 congenic may reside in a gene enhancing Gh induced sex-specific effects.
T19107 7254-7259 VBN denotes Given
T19109 7260-7263 DT denotes the
T19111 7264-7268 RB denotes well
T19112 7269-7279 VBN denotes documented
T19113 7280-7288 RB denotes sexually
T19114 7289-7298 JJ denotes dimorphic
T19110 7299-7305 NN denotes nature
T19115 7306-7308 IN denotes of
T19116 7309-7311 NN denotes Gh
T19117 7312-7321 NN denotes secretion
T19118 7322-7325 CC denotes and
T19119 7326-7328 NN denotes Gh
T19120 7329-7336 VBN denotes induced
T19122 7337-7341 NN denotes gene
T19121 7342-7352 NN denotes expression
T19123 7353-7354 -LRB- denotes [
T19125 7354-7356 CD denotes 42
T19126 7356-7357 , denotes ,
T19124 7357-7359 CD denotes 43
T19127 7359-7360 -RRB- denotes ]
T19128 7360-7362 , denotes ,
T19129 7362-7364 PRP denotes it
T19108 7365-7367 VBZ denotes is
T19130 7368-7376 JJ denotes probable
T19131 7377-7381 IN denotes that
T19133 7382-7385 DT denotes the
T19135 7386-7396 VBG denotes underlying
T19134 7397-7405 NN denotes mutation
T19136 7406-7408 IN denotes in
T19137 7409-7412 DT denotes the
T19138 7413-7417 NN denotes HG11
T19139 7418-7426 JJ denotes congenic
T19140 7427-7430 MD denotes may
T19132 7431-7437 VB denotes reside
T19141 7438-7440 IN denotes in
T19142 7441-7442 DT denotes a
T19143 7443-7447 NN denotes gene
T19144 7448-7457 VBG denotes enhancing
T19145 7458-7460 NN denotes Gh
T19146 7461-7468 VBN denotes induced
T19148 7469-7472 NN denotes sex
T19150 7472-7473 HYPH denotes -
T19149 7473-7481 JJ denotes specific
T19147 7482-7489 NNS denotes effects
T19151 7489-7490 . denotes .
T19152 7490-7557 sentence denotes The structural Gh gene itself and Stat5b are excellent candidates.
T19153 7491-7494 DT denotes The
T19155 7495-7505 JJ denotes structural
T19156 7506-7508 NN denotes Gh
T19154 7509-7513 NN denotes gene
T19158 7514-7520 PRP denotes itself
T19159 7521-7524 CC denotes and
T19160 7525-7531 NN denotes Stat5b
T19157 7532-7535 VBP denotes are
T19161 7536-7545 JJ denotes excellent
T19162 7546-7556 NNS denotes candidates
T19163 7556-7557 . denotes .
T19164 7557-7713 sentence denotes The potential role of Gh would include polymorphism that alters protein function in the absence of Socs2 or that causes transcriptional deregulation of Gh.
T19165 7558-7561 DT denotes The
T19167 7562-7571 JJ denotes potential
T19166 7572-7576 NN denotes role
T19169 7577-7579 IN denotes of
T19170 7580-7582 NN denotes Gh
T19171 7583-7588 MD denotes would
T19168 7589-7596 VB denotes include
T19172 7597-7609 NN denotes polymorphism
T19173 7610-7614 WDT denotes that
T19174 7615-7621 VBZ denotes alters
T19175 7622-7629 NN denotes protein
T19176 7630-7638 NN denotes function
T19177 7639-7641 IN denotes in
T19178 7642-7645 DT denotes the
T19179 7646-7653 NN denotes absence
T19180 7654-7656 IN denotes of
T19181 7657-7662 NN denotes Socs2
T19182 7663-7665 CC denotes or
T19183 7666-7670 DT denotes that
T19184 7671-7677 VBZ denotes causes
T19185 7678-7693 JJ denotes transcriptional
T19186 7694-7706 NN denotes deregulation
T19187 7707-7709 IN denotes of
T19188 7710-7712 NN denotes Gh
T19189 7712-7713 . denotes .
T19190 7713-7924 sentence denotes Additionally, functional variation in Stat5b may explain the sex-specific phenotypes in HG11 mice since it is the primary transcription factor responsible for Gh induced sex-specific liver gene expression [44].
T19191 7714-7726 RB denotes Additionally
T19193 7726-7728 , denotes ,
T19194 7728-7738 JJ denotes functional
T19195 7739-7748 NN denotes variation
T19196 7749-7751 IN denotes in
T19197 7752-7758 NN denotes Stat5b
T19198 7759-7762 MD denotes may
T19192 7763-7770 VB denotes explain
T19199 7771-7774 DT denotes the
T19201 7775-7778 NN denotes sex
T19203 7778-7779 HYPH denotes -
T19202 7779-7787 JJ denotes specific
T19200 7788-7798 NNS denotes phenotypes
T19204 7799-7801 IN denotes in
T19205 7802-7806 NN denotes HG11
T19206 7807-7811 NNS denotes mice
T19207 7812-7817 IN denotes since
T19209 7818-7820 PRP denotes it
T19208 7821-7823 VBZ denotes is
T19210 7824-7827 DT denotes the
T19212 7828-7835 JJ denotes primary
T19213 7836-7849 NN denotes transcription
T19211 7850-7856 NN denotes factor
T19214 7857-7868 JJ denotes responsible
T19215 7869-7872 IN denotes for
T19216 7873-7875 NN denotes Gh
T19217 7876-7883 VBN denotes induced
T19219 7884-7887 NN denotes sex
T19221 7887-7888 HYPH denotes -
T19220 7888-7896 JJ denotes specific
T19222 7897-7902 NN denotes liver
T19223 7903-7907 NN denotes gene
T19218 7908-7918 NN denotes expression
T19224 7919-7920 -LRB- denotes [
T19225 7920-7922 CD denotes 44
T19226 7922-7923 -RRB- denotes ]
T19227 7923-7924 . denotes .
T19228 7924-8093 sentence denotes Future studies aimed at identifying the HG11 QTG, will certainly include a thorough characterization of Gh and Stat5b sequence and expression patterns in congenic mice.
T19229 7925-7931 JJ denotes Future
T19230 7932-7939 NNS denotes studies
T19232 7940-7945 VBN denotes aimed
T19233 7946-7948 IN denotes at
T19234 7949-7960 VBG denotes identifying
T19235 7961-7964 DT denotes the
T19237 7965-7969 NN denotes HG11
T19236 7970-7973 NN denotes QTG
T19238 7973-7975 , denotes ,
T19239 7975-7979 MD denotes will
T19240 7980-7989 RB denotes certainly
T19231 7990-7997 VB denotes include
T19241 7998-7999 DT denotes a
T19243 8000-8008 JJ denotes thorough
T19242 8009-8025 NN denotes characterization
T19244 8026-8028 IN denotes of
T19245 8029-8031 NN denotes Gh
T19247 8032-8035 CC denotes and
T19248 8036-8042 NN denotes Stat5b
T19249 8043-8051 NN denotes sequence
T19250 8052-8055 CC denotes and
T19251 8056-8066 NN denotes expression
T19246 8067-8075 NNS denotes patterns
T19252 8076-8078 IN denotes in
T19253 8079-8087 JJ denotes congenic
T19254 8088-8092 NNS denotes mice
T19255 8092-8093 . denotes .
T19256 8093-8209 sentence denotes The hg modifier QTL located within the HG17 strain had large effects on growth, body length and carcass components.
T19257 8094-8097 DT denotes The
T19259 8098-8100 NN denotes hg
T19260 8101-8109 NN denotes modifier
T19258 8110-8113 NN denotes QTL
T19262 8114-8121 VBN denotes located
T19263 8122-8128 IN denotes within
T19264 8129-8132 DT denotes the
T19266 8133-8137 NN denotes HG17
T19265 8138-8144 NN denotes strain
T19261 8145-8148 VBD denotes had
T19267 8149-8154 JJ denotes large
T19268 8155-8162 NNS denotes effects
T19269 8163-8165 IN denotes on
T19270 8166-8172 NN denotes growth
T19271 8172-8174 , denotes ,
T19272 8174-8178 NN denotes body
T19273 8179-8185 NN denotes length
T19274 8186-8189 CC denotes and
T19275 8190-8197 NN denotes carcass
T19276 8198-8208 NNS denotes components
T19277 8208-8209 . denotes .
T19278 8209-8278 sentence denotes The most intriguing candidate gene located in the congenic is Sstr5.
T19279 8210-8213 DT denotes The
T19281 8214-8218 RBS denotes most
T19282 8219-8229 JJ denotes intriguing
T19283 8230-8239 NN denotes candidate
T19280 8240-8244 NN denotes gene
T19285 8245-8252 VBN denotes located
T19286 8253-8255 IN denotes in
T19287 8256-8259 DT denotes the
T19288 8260-8268 JJ denotes congenic
T19284 8269-8271 VBZ denotes is
T19289 8272-8277 NN denotes Sstr5
T19290 8277-8278 . denotes .
T19291 8278-8391 sentence denotes Somatostatin is a potent inhibitor of Gh and Sstr5 is one of five receptors which mediate these effects [45,46].
T19292 8279-8291 NN denotes Somatostatin
T19293 8292-8294 VBZ denotes is
T19294 8295-8296 DT denotes a
T19296 8297-8303 JJ denotes potent
T19295 8304-8313 NN denotes inhibitor
T19297 8314-8316 IN denotes of
T19298 8317-8319 NN denotes Gh
T19299 8320-8323 CC denotes and
T19300 8324-8329 NN denotes Sstr5
T19301 8330-8332 VBZ denotes is
T19302 8333-8336 CD denotes one
T19303 8337-8339 IN denotes of
T19304 8340-8344 CD denotes five
T19305 8345-8354 NNS denotes receptors
T19306 8355-8360 WDT denotes which
T19307 8361-8368 VBP denotes mediate
T19308 8369-8374 DT denotes these
T19309 8375-8382 NNS denotes effects
T19310 8383-8384 -LRB- denotes [
T19312 8384-8386 CD denotes 45
T19313 8386-8387 , denotes ,
T19311 8387-8389 CD denotes 46
T19314 8389-8390 -RRB- denotes ]
T19315 8390-8391 . denotes .
T19316 8391-8529 sentence denotes Ubiquitous and pancreatic beta cell specific knockout of Sstr5 leads to alterations in insulin secretion and glucose homeostasis [47,48].
T19317 8392-8402 JJ denotes Ubiquitous
T19319 8403-8406 CC denotes and
T19320 8407-8417 JJ denotes pancreatic
T19322 8418-8422 NN denotes beta
T19321 8423-8427 NN denotes cell
T19323 8428-8436 JJ denotes specific
T19318 8437-8445 NN denotes knockout
T19325 8446-8448 IN denotes of
T19326 8449-8454 NN denotes Sstr5
T19324 8455-8460 VBZ denotes leads
T19327 8461-8463 IN denotes to
T19328 8464-8475 NNS denotes alterations
T19329 8476-8478 IN denotes in
T19330 8479-8486 NN denotes insulin
T19331 8487-8496 NN denotes secretion
T19332 8497-8500 CC denotes and
T19333 8501-8508 NN denotes glucose
T19334 8509-8520 NN denotes homeostasis
T19335 8521-8522 -LRB- denotes [
T19337 8522-8524 CD denotes 47
T19338 8524-8525 , denotes ,
T19336 8525-8527 CD denotes 48
T19339 8527-8528 -RRB- denotes ]
T19340 8528-8529 . denotes .
T19341 8529-8651 sentence denotes We sequenced candidate hg modifier genes to complement the characterization of the speed congenics on MMU2, 9, 11 and 17.
T19342 8530-8532 PRP denotes We
T19343 8533-8542 VBD denotes sequenced
T19344 8543-8552 NN denotes candidate
T19346 8553-8555 NN denotes hg
T19347 8556-8564 NN denotes modifier
T19345 8565-8570 NNS denotes genes
T19348 8571-8573 TO denotes to
T19349 8574-8584 VB denotes complement
T19350 8585-8588 DT denotes the
T19351 8589-8605 NN denotes characterization
T19352 8606-8608 IN denotes of
T19353 8609-8612 DT denotes the
T19355 8613-8618 NN denotes speed
T19354 8619-8628 NNS denotes congenics
T19356 8629-8631 IN denotes on
T19357 8632-8635 NN denotes MMU
T19358 8635-8636 CD denotes 2
T19359 8636-8638 , denotes ,
T19360 8638-8639 CD denotes 9
T19361 8639-8641 , denotes ,
T19362 8641-8643 CD denotes 11
T19363 8644-8647 CC denotes and
T19364 8648-8650 CD denotes 17
T19365 8650-8651 . denotes .
T19366 8651-8848 sentence denotes A limited number of studies have identified variation within CAST coding sequence; so sequencing candidates gave us the opportunity to estimate the SNP frequency in coding sequence relative to B6.
T19367 8652-8653 DT denotes A
T19369 8654-8661 JJ denotes limited
T19368 8662-8668 NN denotes number
T19371 8669-8671 IN denotes of
T19372 8672-8679 NNS denotes studies
T19373 8680-8684 VBP denotes have
T19370 8685-8695 VBN denotes identified
T19374 8696-8705 NN denotes variation
T19375 8706-8712 IN denotes within
T19376 8713-8717 NN denotes CAST
T19378 8718-8724 NN denotes coding
T19377 8725-8733 NN denotes sequence
T19379 8733-8734 : denotes ;
T19380 8735-8737 CC denotes so
T19381 8738-8748 VBG denotes sequencing
T19382 8749-8759 NNS denotes candidates
T19383 8760-8764 VBD denotes gave
T19384 8765-8767 PRP denotes us
T19385 8768-8771 DT denotes the
T19386 8772-8783 NN denotes opportunity
T19387 8784-8786 TO denotes to
T19388 8787-8795 VB denotes estimate
T19389 8796-8799 DT denotes the
T19391 8800-8803 NN denotes SNP
T19390 8804-8813 NN denotes frequency
T19392 8814-8816 IN denotes in
T19393 8817-8823 NN denotes coding
T19394 8824-8832 NN denotes sequence
T19395 8833-8841 JJ denotes relative
T19396 8842-8844 IN denotes to
T19397 8845-8847 NN denotes B6
T19398 8847-8848 . denotes .
T19399 8848-8956 sentence denotes This information will be vital to future fine mapping studies, which will include gene expression analysis.
T19400 8849-8853 DT denotes This
T19401 8854-8865 NN denotes information
T19403 8866-8870 MD denotes will
T19402 8871-8873 VB denotes be
T19404 8874-8879 JJ denotes vital
T19405 8880-8882 IN denotes to
T19406 8883-8889 JJ denotes future
T19408 8890-8894 JJ denotes fine
T19409 8895-8902 NN denotes mapping
T19407 8903-8910 NNS denotes studies
T19410 8910-8912 , denotes ,
T19411 8912-8917 WDT denotes which
T19413 8918-8922 MD denotes will
T19412 8923-8930 VB denotes include
T19414 8931-8935 NN denotes gene
T19415 8936-8946 NN denotes expression
T19416 8947-8955 NN denotes analysis
T19417 8955-8956 . denotes .
T19418 8956-9170 sentence denotes The high SNP frequency (0.312%; 295 SNP in 94.492 kbp) in CAST genes may lead to a higher rate of false positives using DNA microarrays or quantitative real-time PCR assays, most of which are based on B6 sequence.
T19419 8957-8960 DT denotes The
T19421 8961-8965 JJ denotes high
T19422 8966-8969 NN denotes SNP
T19420 8970-8979 NN denotes frequency
T19424 8980-8981 -LRB- denotes (
T19426 8981-8986 CD denotes 0.312
T19427 8986-8987 NN denotes %
T19428 8987-8988 : denotes ;
T19429 8989-8992 CD denotes 295
T19425 8993-8996 NN denotes SNP
T19430 8997-8999 IN denotes in
T19431 9000-9006 CD denotes 94.492
T19432 9007-9010 NN denotes kbp
T19433 9010-9011 -RRB- denotes )
T19434 9012-9014 IN denotes in
T19435 9015-9019 NN denotes CAST
T19436 9020-9025 NNS denotes genes
T19437 9026-9029 MD denotes may
T19423 9030-9034 VB denotes lead
T19438 9035-9037 IN denotes to
T19439 9038-9039 DT denotes a
T19441 9040-9046 JJR denotes higher
T19440 9047-9051 NN denotes rate
T19442 9052-9054 IN denotes of
T19443 9055-9060 JJ denotes false
T19444 9061-9070 NNS denotes positives
T19445 9071-9076 VBG denotes using
T19446 9077-9080 NN denotes DNA
T19447 9081-9092 NNS denotes microarrays
T19448 9093-9095 CC denotes or
T19449 9096-9108 JJ denotes quantitative
T19451 9109-9113 JJ denotes real
T19453 9113-9114 HYPH denotes -
T19452 9114-9118 NN denotes time
T19454 9119-9122 NN denotes PCR
T19450 9123-9129 NNS denotes assays
T19455 9129-9131 , denotes ,
T19456 9131-9135 JJS denotes most
T19458 9136-9138 IN denotes of
T19459 9139-9144 WDT denotes which
T19460 9145-9148 VBP denotes are
T19457 9149-9154 VBN denotes based
T19461 9155-9157 IN denotes on
T19462 9158-9160 NN denotes B6
T19463 9161-9169 NN denotes sequence
T19464 9169-9170 . denotes .
T19465 9170-9401 sentence denotes Therefore, these sequence data can be used to guide the development of gene expression assays to confirm differential expression for candidates and suggests that genes identified by downstream experiments should also be sequenced.
T19466 9171-9180 RB denotes Therefore
T19468 9180-9182 , denotes ,
T19469 9182-9187 DT denotes these
T19471 9188-9196 NN denotes sequence
T19470 9197-9201 NNS denotes data
T19472 9202-9205 MD denotes can
T19473 9206-9208 VB denotes be
T19467 9209-9213 VBN denotes used
T19474 9214-9216 TO denotes to
T19475 9217-9222 VB denotes guide
T19476 9223-9226 DT denotes the
T19477 9227-9238 NN denotes development
T19478 9239-9241 IN denotes of
T19479 9242-9246 NN denotes gene
T19480 9247-9257 NN denotes expression
T19481 9258-9264 NNS denotes assays
T19482 9265-9267 TO denotes to
T19483 9268-9275 VB denotes confirm
T19484 9276-9288 JJ denotes differential
T19485 9289-9299 NN denotes expression
T19486 9300-9303 IN denotes for
T19487 9304-9314 NNS denotes candidates
T19488 9315-9318 CC denotes and
T19489 9319-9327 VBZ denotes suggests
T19490 9328-9332 IN denotes that
T19492 9333-9338 NNS denotes genes
T19493 9339-9349 VBN denotes identified
T19494 9350-9352 IN denotes by
T19495 9353-9363 JJ denotes downstream
T19496 9364-9375 NNS denotes experiments
T19497 9376-9382 MD denotes should
T19498 9383-9387 RB denotes also
T19499 9388-9390 VB denotes be
T19491 9391-9400 VBN denotes sequenced
T19500 9400-9401 . denotes .
T19501 9401-9528 sentence denotes More importantly, sequencing hg modifier candidates allowed us to identify nonsynonomous polymorphism, which may underlie QTL.
T19502 9402-9406 RBR denotes More
T19503 9407-9418 RB denotes importantly
T19505 9418-9420 , denotes ,
T19506 9420-9430 VBG denotes sequencing
T19507 9431-9433 NN denotes hg
T19508 9434-9442 NN denotes modifier
T19509 9443-9453 NNS denotes candidates
T19504 9454-9461 VBD denotes allowed
T19510 9462-9464 PRP denotes us
T19512 9465-9467 TO denotes to
T19511 9468-9476 VB denotes identify
T19513 9477-9490 JJ denotes nonsynonomous
T19514 9491-9503 NN denotes polymorphism
T19515 9503-9505 , denotes ,
T19516 9505-9510 WDT denotes which
T19518 9511-9514 MD denotes may
T19517 9515-9523 VB denotes underlie
T19519 9524-9527 NN denotes QTL
T19520 9527-9528 . denotes .
T19521 9528-9673 sentence denotes SIFT and/or PolyPhen predicted alterations in protein function for 15 of the 56 total nsSNP (27%) in nine of the 44 total genes (20%) (Table 7).
T19522 9529-9533 NNP denotes SIFT
T19524 9534-9537 CC denotes and
T19525 9537-9538 HYPH denotes /
T19526 9538-9540 CC denotes or
T19527 9541-9549 NNP denotes PolyPhen
T19523 9550-9559 VBN denotes predicted
T19528 9560-9571 NNS denotes alterations
T19529 9572-9574 IN denotes in
T19530 9575-9582 NN denotes protein
T19531 9583-9591 NN denotes function
T19532 9592-9595 IN denotes for
T19533 9596-9598 CD denotes 15
T19534 9599-9601 IN denotes of
T19535 9602-9605 DT denotes the
T19537 9606-9608 CD denotes 56
T19538 9609-9614 JJ denotes total
T19536 9615-9620 NN denotes nsSNP
T19539 9621-9622 -LRB- denotes (
T19541 9622-9624 CD denotes 27
T19540 9624-9625 NN denotes %
T19542 9625-9626 -RRB- denotes )
T19543 9627-9629 IN denotes in
T19544 9630-9634 CD denotes nine
T19545 9635-9637 IN denotes of
T19546 9638-9641 DT denotes the
T19548 9642-9644 CD denotes 44
T19549 9645-9650 JJ denotes total
T19547 9651-9656 NNS denotes genes
T19550 9657-9658 -LRB- denotes (
T19552 9658-9660 CD denotes 20
T19551 9660-9661 NN denotes %
T19553 9661-9662 -RRB- denotes )
T19554 9663-9664 -LRB- denotes (
T19555 9664-9669 NN denotes Table
T19556 9670-9671 CD denotes 7
T19557 9671-9672 -RRB- denotes )
T19558 9672-9673 . denotes .
T19559 9673-9815 sentence denotes It has been shown that predicting function based on evolutionary conservation using programs such as SIFT and PolyPhen is very accurate [49].
T19560 9674-9676 PRP denotes It
T19562 9677-9680 VBZ denotes has
T19563 9681-9685 VBN denotes been
T19561 9686-9691 VBN denotes shown
T19564 9692-9696 IN denotes that
T19566 9697-9707 VBG denotes predicting
T19567 9708-9716 NN denotes function
T19568 9717-9722 VBN denotes based
T19569 9723-9725 IN denotes on
T19570 9726-9738 JJ denotes evolutionary
T19571 9739-9751 NN denotes conservation
T19572 9752-9757 VBG denotes using
T19573 9758-9766 NNS denotes programs
T19574 9767-9771 JJ denotes such
T19575 9772-9774 IN denotes as
T19576 9775-9779 NNP denotes SIFT
T19577 9780-9783 CC denotes and
T19578 9784-9792 NNP denotes PolyPhen
T19565 9793-9795 VBZ denotes is
T19579 9796-9800 RB denotes very
T19580 9801-9809 JJ denotes accurate
T19581 9810-9811 -LRB- denotes [
T19582 9811-9813 CD denotes 49
T19583 9813-9814 -RRB- denotes ]
T19584 9814-9815 . denotes .
T19585 9815-9926 sentence denotes Four of the nine genes (Ubr1, Ptpns1, Ubce7ip5 and Mmp9; all of which are on MMU2) are of particular interest.
T19586 9816-9820 CD denotes Four
T19588 9821-9823 IN denotes of
T19589 9824-9827 DT denotes the
T19591 9828-9832 CD denotes nine
T19590 9833-9838 NNS denotes genes
T19592 9839-9840 -LRB- denotes (
T19593 9840-9844 NN denotes Ubr1
T19594 9844-9846 , denotes ,
T19595 9846-9852 NN denotes Ptpns1
T19596 9852-9854 , denotes ,
T19597 9854-9862 NN denotes Ubce7ip5
T19598 9863-9866 CC denotes and
T19599 9867-9871 NN denotes Mmp9
T19600 9871-9872 : denotes ;
T19601 9873-9876 DT denotes all
T19603 9877-9879 IN denotes of
T19604 9880-9885 WDT denotes which
T19602 9886-9889 VBP denotes are
T19605 9890-9892 IN denotes on
T19606 9893-9897 NN denotes MMU2
T19607 9897-9898 -RRB- denotes )
T19587 9899-9902 VBP denotes are
T19608 9903-9905 IN denotes of
T19609 9906-9916 JJ denotes particular
T19610 9917-9925 NN denotes interest
T19611 9925-9926 . denotes .
T19612 9926-10049 sentence denotes It has been suggested the Socs2 may rely on ubiquitination dependent proteasomal degradation to inhibit Gh signaling [23].
T19613 9927-9929 PRP denotes It
T19615 9930-9933 VBZ denotes has
T19616 9934-9938 VBN denotes been
T19614 9939-9948 VBN denotes suggested
T19617 9949-9952 DT denotes the
T19618 9953-9958 NN denotes Socs2
T19620 9959-9962 MD denotes may
T19619 9963-9967 VB denotes rely
T19621 9968-9970 IN denotes on
T19622 9971-9985 NN denotes ubiquitination
T19623 9986-9995 JJ denotes dependent
T19625 9996-10007 JJ denotes proteasomal
T19624 10008-10019 NN denotes degradation
T19626 10020-10022 TO denotes to
T19627 10023-10030 VB denotes inhibit
T19628 10031-10033 NN denotes Gh
T19629 10034-10043 NN denotes signaling
T19630 10044-10045 -LRB- denotes [
T19631 10045-10047 CD denotes 23
T19632 10047-10048 -RRB- denotes ]
T19633 10048-10049 . denotes .
T19634 10049-10223 sentence denotes Ubr1 and Ubce7ip5 are both involved in protein ubiquitination and Ubr1 knockout mice show an 20% decrease in body weight partly due to a reduction in adipose tissue [50,51].
T19635 10050-10054 NN denotes Ubr1
T19637 10055-10058 CC denotes and
T19638 10059-10067 NN denotes Ubce7ip5
T19639 10068-10071 VBP denotes are
T19640 10072-10076 RB denotes both
T19636 10077-10085 VBN denotes involved
T19641 10086-10088 IN denotes in
T19642 10089-10096 NN denotes protein
T19643 10097-10111 NN denotes ubiquitination
T19644 10112-10115 CC denotes and
T19645 10116-10120 NN denotes Ubr1
T19646 10121-10129 NN denotes knockout
T19647 10130-10134 NNS denotes mice
T19648 10135-10139 VBP denotes show
T19649 10140-10142 DT denotes an
T19651 10143-10145 CD denotes 20
T19652 10145-10146 NN denotes %
T19650 10147-10155 NN denotes decrease
T19653 10156-10158 IN denotes in
T19654 10159-10163 NN denotes body
T19655 10164-10170 NN denotes weight
T19656 10171-10177 RB denotes partly
T19657 10178-10181 IN denotes due
T19658 10182-10184 IN denotes to
T19659 10185-10186 DT denotes a
T19660 10187-10196 NN denotes reduction
T19661 10197-10199 IN denotes in
T19662 10200-10207 NN denotes adipose
T19663 10208-10214 NN denotes tissue
T19664 10215-10216 -LRB- denotes [
T19666 10216-10218 CD denotes 50
T19667 10218-10219 , denotes ,
T19665 10219-10221 CD denotes 51
T19668 10221-10222 -RRB- denotes ]
T19669 10222-10223 . denotes .
T19670 10223-10380 sentence denotes Ptpns1 knockout mice displayed a 10% reduction in body weight [52] and Mmp9 knockout mice show a reduction in size and drastically reduced bone length [53].
T19671 10224-10230 NN denotes Ptpns1
T19673 10231-10239 NN denotes knockout
T19672 10240-10244 NNS denotes mice
T19674 10245-10254 VBD denotes displayed
T19675 10255-10256 DT denotes a
T19677 10257-10259 CD denotes 10
T19678 10259-10260 NN denotes %
T19676 10261-10270 NN denotes reduction
T19679 10271-10273 IN denotes in
T19680 10274-10278 NN denotes body
T19681 10279-10285 NN denotes weight
T19682 10286-10287 -LRB- denotes [
T19683 10287-10289 CD denotes 52
T19684 10289-10290 -RRB- denotes ]
T19685 10291-10294 CC denotes and
T19686 10295-10299 NN denotes Mmp9
T19688 10300-10308 NN denotes knockout
T19687 10309-10313 NNS denotes mice
T19689 10314-10318 VBP denotes show
T19690 10319-10320 DT denotes a
T19691 10321-10330 NN denotes reduction
T19692 10331-10333 IN denotes in
T19693 10334-10338 NN denotes size
T19694 10339-10342 CC denotes and
T19695 10343-10354 RB denotes drastically
T19696 10355-10362 VBN denotes reduced
T19698 10363-10367 NN denotes bone
T19697 10368-10374 NN denotes length
T19699 10375-10376 -LRB- denotes [
T19700 10376-10378 CD denotes 53
T19701 10378-10379 -RRB- denotes ]
T19702 10379-10380 . denotes .
T19703 10380-10542 sentence denotes All of these genes are excellent functional and positional hg modifier candidate genes and this information can be incorporated into future fine mapping studies.
T19704 10381-10384 DT denotes All
T19706 10385-10387 IN denotes of
T19707 10388-10393 DT denotes these
T19708 10394-10399 NNS denotes genes
T19705 10400-10403 VBP denotes are
T19709 10404-10413 JJ denotes excellent
T19711 10414-10424 JJ denotes functional
T19712 10425-10428 CC denotes and
T19713 10429-10439 JJ denotes positional
T19714 10440-10442 NN denotes hg
T19715 10443-10451 NN denotes modifier
T19716 10452-10461 NN denotes candidate
T19710 10462-10467 NNS denotes genes
T19717 10468-10471 CC denotes and
T19718 10472-10476 DT denotes this
T19719 10477-10488 NN denotes information
T19721 10489-10492 MD denotes can
T19722 10493-10495 VB denotes be
T19720 10496-10508 VBN denotes incorporated
T19723 10509-10513 IN denotes into
T19724 10514-10520 JJ denotes future
T19726 10521-10525 JJ denotes fine
T19727 10526-10533 NN denotes mapping
T19725 10534-10541 NNS denotes studies
T19728 10541-10542 . denotes .
R4337 T17718 T17719 npadvmod Speed,congenic
R4338 T17719 T17720 amod congenic,strains
R4339 T17720 T17721 nsubj strains,provide
R4340 T17722 T17723 det a,approach
R4341 T17723 T17721 dobj approach,provide
R4342 T17724 T17723 amod powerful,approach
R4343 T17725 T17726 aux to,confirm
R4344 T17726 T17723 acl confirm,approach
R4345 T17727 T17726 cc and,confirm
R4346 T17728 T17729 advmod physically,confine
R4347 T17729 T17726 conj confine,confirm
R4348 T17730 T17729 dobj QTL,confine
R4349 T17731 T17729 prep within,confine
R4350 T17732 T17731 pobj intervals,within
R4351 T17733 T17732 acl defined,intervals
R4352 T17734 T17733 prep by,defined
R4353 T17735 T17736 amod molecular,markers
R4354 T17736 T17734 pobj markers,by
R4355 T17737 T17721 punct .,provide
R4356 T17739 T17740 prep In,isolated
R4357 T17741 T17742 det the,study
R4358 T17742 T17739 pobj study,In
R4359 T17743 T17742 amod current,study
R4360 T17744 T17740 punct ", ",isolated
R4361 T17745 T17746 advmod approximately,20
R4362 T17746 T17747 nummod 20,%
R4363 T17747 T17740 nsubjpass %,isolated
R4364 T17748 T17747 prep of,%
R4365 T17749 T17750 det the,genome
R4366 T17750 T17748 pobj genome,of
R4367 T17751 T17750 compound CAST,genome
R4368 T17752 T17750 acl harboring,genome
R4369 T17753 T17754 advmod all,QTL
R4370 T17754 T17752 dobj QTL,harboring
R4371 T17755 T17756 advmod previously,detected
R4372 T17756 T17754 amod detected,QTL
R4373 T17757 T17758 nmod growth,composition
R4374 T17758 T17754 compound composition,QTL
R4375 T17759 T17757 cc and,growth
R4376 T17760 T17757 conj carcass,growth
R4377 T17761 T17740 auxpass was,isolated
R4378 T17762 T17740 prep on,isolated
R4379 T17763 T17764 det an,background
R4380 T17764 T17762 pobj background,on
R4381 T17765 T17764 nmod HG,background
R4382 T17766 T17765 cc or,HG
R4383 T17767 T17765 conj B6,HG
R4384 T17768 T17740 prep through,isolated
R4385 T17769 T17770 det the,development
R4386 T17770 T17768 pobj development,through
R4387 T17771 T17770 prep of,development
R4388 T17772 T17773 nummod 14,strains
R4389 T17773 T17771 pobj strains,of
R4390 T17774 T17775 npadvmod speed,congenic
R4391 T17775 T17773 amod congenic,strains
R4392 T17776 T17740 punct .,isolated
R4393 T17778 T17779 nummod Two,panels
R4394 T17779 T17783 nsubjpass panels,developed
R4395 T17780 T17779 amod distinct,panels
R4396 T17781 T17782 npadvmod speed,congenic
R4397 T17782 T17779 amod congenic,panels
R4398 T17783 T17785 ccomp developed,provided
R4399 T17784 T17783 auxpass were,developed
R4400 T17786 T17785 punct ", ",provided
R4401 T17787 T17788 det the,first
R4402 T17788 T17785 nsubj first,provided
R4403 T17789 T17790 det a,isolation
R4404 T17790 T17785 dobj isolation,provided
R4405 T17791 T17790 amod comprehensive,isolation
R4406 T17792 T17790 prep of,isolation
R4407 T17793 T17794 det all,QTL
R4408 T17794 T17792 pobj QTL,of
R4409 T17795 T17794 compound MMU2,QTL
R4410 T17796 T17794 prep between,QTL
R4411 T17797 T17798 det the,strains
R4412 T17798 T17796 pobj strains,between
R4413 T17799 T17798 nmod B6,strains
R4414 T17800 T17799 punct ", ",B6
R4415 T17801 T17799 conj HG,B6
R4416 T17802 T17801 cc and,HG
R4417 T17803 T17801 conj CAST,HG
R4418 T17804 T17785 cc and,provided
R4419 T17805 T17806 det the,second
R4420 T17806 T17807 nsubj second,targeted
R4421 T17807 T17785 conj targeted,provided
R4422 T17808 T17809 det all,QTL
R4423 T17809 T17807 dobj QTL,targeted
R4424 T17810 T17809 prep outside,QTL
R4425 T17811 T17810 prep of,outside
R4426 T17812 T17811 pobj MMU2,of
R4427 T17813 T17785 punct .,provided
R4428 T17815 T17816 det Each,strain
R4429 T17816 T17819 nsubj strain,exhibited
R4430 T17817 T17818 advmod successfully,characterized
R4431 T17818 T17816 amod characterized,strain
R4432 T17820 T17821 amod phenotypic,differences
R4433 T17821 T17819 dobj differences,exhibited
R4434 T17822 T17819 advcl relative,exhibited
R4435 T17823 T17822 prep to,relative
R4436 T17824 T17825 compound control,mice
R4437 T17825 T17823 pobj mice,to
R4438 T17826 T17819 punct .,exhibited
R4439 T17828 T17829 det These,strains
R4440 T17829 T17830 nsubj strains,represent
R4441 T17831 T17832 amod important,resources
R4442 T17832 T17830 dobj resources,represent
R4443 T17833 T17830 cc and,represent
R4444 T17834 T17830 conj provide,represent
R4445 T17835 T17836 det the,resource
R4446 T17836 T17834 dobj resource,provide
R4447 T17837 T17836 amod genetic,resource
R4448 T17838 T17839 aux to,clone
R4449 T17839 T17836 advcl clone,resource
R4450 T17840 T17839 advmod positionally,clone
R4451 T17841 T17842 amod numerous,genes
R4452 T17842 T17839 dobj genes,clone
R4453 T17843 T17844 amod quantitative,trait
R4454 T18103 T18100 pobj variation,due
R4455 T17844 T17842 compound trait,genes
R4456 T18104 T18103 prep within,variation
R4457 T17845 T17830 punct .,represent
R4458 T18105 T18106 det each,region
R4459 T18106 T18104 pobj region,within
R4460 T17847 T17848 nummod One,criticism
R4461 T18107 T18106 compound donor,region
R4462 T18108 T18076 punct .,screened
R4463 T17848 T17849 nsubj criticism,is
R4464 T18110 T18111 mark Although,put
R4465 T18111 T18115 advcl put,confound
R4466 T17850 T17848 prep of,criticism
R4467 T18112 T18113 amod great,effort
R4468 T18113 T18111 nsubjpass effort,put
R4469 T18114 T18111 auxpass was,put
R4470 T17851 T17852 det the,approach
R4471 T18116 T18111 prt forth,put
R4472 T18117 T18118 aux to,eliminate
R4473 T17852 T17850 pobj approach,of
R4474 T18118 T18111 advcl eliminate,put
R4475 T18119 T18120 amod non-donor,region
R4476 T17853 T17854 npadvmod speed,congenic
R4477 T18120 T18121 nmod region,effects
R4478 T18121 T18118 dobj effects,eliminate
R4479 T18122 T18121 amod direct,effects
R4480 T17854 T17852 amod congenic,approach
R4481 T18123 T18121 amod genetic,effects
R4482 T18124 T18115 punct ", ",confound
R4483 T18125 T18126 amod other,factors
R4484 T17855 T17856 det the,potential
R4485 T18126 T18115 nsubj factors,confound
R4486 T17856 T17849 attr potential,is
R4487 T17857 T17858 mark for,reside
R4488 T17858 T17856 advcl reside,potential
R4489 T17859 T17858 nsubj QTL,reside
R4490 T18127 T18128 amod such,as
R4491 T18128 T18126 prep as,factors
R4492 T18129 T18130 amod maternal,genotype
R4493 T18130 T18128 pobj genotype,as
R4494 T17860 T17858 aux to,reside
R4495 T18131 T18132 punct (,differed
R4496 T18132 T18130 parataxis differed,genotype
R4497 T18133 T18134 amod maternal,genotype
R4498 T17861 T17858 prep among,reside
R4499 T18134 T18132 nsubj genotype,differed
R4500 T17862 T17863 amod unwanted,alleles
R4501 T18135 T18134 prep for,genotype
R4502 T18136 T18137 det each,congenic
R4503 T18137 T18135 pobj congenic,for
R4504 T18138 T18134 cc versus,genotype
R4505 T18139 T18140 compound control,dams
R4506 T17863 T17861 pobj alleles,among
R4507 T18140 T18134 conj dams,genotype
R4508 T18141 T18132 punct ),differed
R4509 T18142 T18126 cc and,factors
R4510 T18143 T18144 amod environmental,effects
R4511 T18144 T18126 conj effects,factors
R4512 T18145 T18115 aux could,confound
R4513 T18146 T18147 poss our,results
R4514 T18147 T18115 dobj results,confound
R4515 T18148 T18115 punct .,confound
R4516 T17864 T17863 compound donor,alleles
R4517 T18150 T18151 amod Maternal,genotype
R4518 T18151 T18152 compound genotype,effects
R4519 T17865 T17866 neg not,eliminated
R4520 T18152 T18153 nsubjpass effects,observed
R4521 T18154 T18152 prep on,effects
R4522 T17866 T17863 acl eliminated,alleles
R4523 T18155 T18154 pobj growth,on
R4524 T18156 T18155 cc and,growth
R4525 T17867 T17866 prep during,eliminated
R4526 T18157 T18155 conj obesity,growth
R4527 T18158 T18153 aux have,observed
R4528 T18159 T18153 auxpass been,observed
R4529 T17868 T17867 pobj backcrossing,during
R4530 T18160 T18153 prep in,observed
R4531 T18161 T18162 det a,number
R4532 T18162 T18160 pobj number,in
R4533 T17869 T17849 punct .,is
R4534 T18163 T18162 prep of,number
R4535 T18164 T18165 compound mouse,crosses
R4536 T17871 T17872 prep In,be
R4537 T18165 T18163 pobj crosses,of
R4538 T18166 T18167 punct [,8
R4539 T18167 T18153 parataxis 8,observed
R4540 T18168 T18167 punct ",",8
R4541 T17873 T17874 det this,case
R4542 T18169 T18167 appos 32,8
R4543 T18170 T18171 punct -,35
R4544 T18171 T18169 prep 35,32
R4545 T18172 T18167 punct ],8
R4546 T18173 T18153 cc and,observed
R4547 T18174 T18175 poss their,existence
R4548 T18175 T18176 nsubjpass existence,discounted
R4549 T17874 T17871 pobj case,In
R4550 T18176 T18153 conj discounted,observed
R4551 T18177 T18175 prep in,existence
R4552 T18178 T18179 det the,cross
R4553 T17875 T17872 nsubj differences,be
R4554 T18179 T18177 pobj cross,in
R4555 T18180 T18179 amod current,cross
R4556 T18181 T18176 aux can,discounted
R4557 T17876 T17875 prep between,differences
R4558 T18182 T18176 neg not,discounted
R4559 T18183 T18176 auxpass be,discounted
R4560 T18184 T18176 punct .,discounted
R4561 T17877 T17878 det the,strains
R4562 T18186 T18187 advmod However,provide
R4563 T17878 T17876 pobj strains,between
R4564 T18188 T18187 punct ", ",provide
R4565 T18189 T18190 poss our,congenics
R4566 T17879 T17878 amod congenic,strains
R4567 T18190 T18187 nsubj congenics,provide
R4568 T18191 T18192 det the,resource
R4569 T17880 T17879 cc and,congenic
R4570 T18192 T18187 dobj resource,provide
R4571 T18193 T18192 amod ideal,resource
R4572 T18194 T18192 nmod foundation,resource
R4573 T17881 T17879 conj control,congenic
R4574 T18195 T18192 amod genomic,resource
R4575 T18196 T18197 aux to,test
R4576 T18197 T18192 advcl test,resource
R4577 T17882 T17872 aux would,be
R4578 T18198 T18197 prep for,test
R4579 T18199 T18200 det the,influence
R4580 T18200 T18198 pobj influence,for
R4581 T17883 T17872 prep due,be
R4582 T18201 T18200 prep of,influence
R4583 T18202 T18201 pobj any,of
R4584 T18203 T18202 prep of,any
R4585 T17884 T17883 prep in,due
R4586 T18204 T18205 det these,effects
R4587 T18205 T18203 pobj effects,of
R4588 T17885 T17884 pobj part,in
R4589 T17886 T17885 cc or,part
R4590 T18206 T18205 amod possible,effects
R4591 T18207 T18187 punct .,provide
R4592 T17887 T17885 conj whole,part
R4593 T18209 T18210 amod Future,experiments
R4594 T18210 T18213 nsubjpass experiments,designed
R4595 T18211 T18212 amod fine,mapping
R4596 T17888 T17883 pcomp to,due
R4597 T18212 T18210 compound mapping,experiments
R4598 T17889 T17890 det these,alleles
R4599 T17890 T17883 pobj alleles,due
R4600 T17891 T17890 amod contaminating,alleles
R4601 T17892 T17872 punct .,be
R4602 T17894 T17895 nsubj We,took
R4603 T18214 T18213 aux can,designed
R4604 T18215 T18213 auxpass be,designed
R4605 T18216 T18217 aux to,randomize
R4606 T17896 T17897 amod several,precautions
R4607 T18217 T18213 advcl randomize,designed
R4608 T18218 T18219 det the,influences
R4609 T17897 T17895 dobj precautions,took
R4610 T18219 T18217 dobj influences,randomize
R4611 T18220 T18219 prep of,influences
R4612 T18221 T18222 det any,alleles
R4613 T17898 T17899 aux to,reduce
R4614 T18222 T18220 pobj alleles,of
R4615 T18223 T18222 amod contaminating,alleles
R4616 T17899 T17895 advcl reduce,took
R4617 T18224 T18222 compound donor,alleles
R4618 T18225 T18222 cc and,alleles
R4619 T18226 T18227 amod environmental,differences
R4620 T17900 T17901 det the,probability
R4621 T18227 T18222 conj differences,alleles
R4622 T18228 T18217 punct ", ",randomize
R4623 T18229 T18230 advmod as,as
R4624 T17901 T17899 dobj probability,reduce
R4625 T18230 T18217 cc as,randomize
R4626 T18231 T18230 advmod well,as
R4627 T18232 T18217 conj test,randomize
R4628 T17902 T17901 prep of,probability
R4629 T18233 T18232 prep for,test
R4630 T18234 T18235 amod maternal,genotype
R4631 T17903 T17904 det this,occurrence
R4632 T18235 T18236 compound genotype,effects
R4633 T18236 T18233 pobj effects,for
R4634 T18237 T18213 punct .,designed
R4635 T17904 T17902 pobj occurrence,of
R4636 T18239 T18240 nsubj MMU2,is
R4637 T17905 T17895 punct .,took
R4638 T18241 T18242 det a,hotspot
R4639 T18242 T18240 attr hotspot,is
R4640 T17907 T17908 advmod First,developed
R4641 T18243 T18242 prep for,hotspot
R4642 T18244 T18245 nmod growth,QTL
R4643 T18245 T18243 pobj QTL,for
R4644 T18246 T18244 cc and,growth
R4645 T17909 T17908 punct ", ",developed
R4646 T18247 T18244 conj obesity,growth
R4647 T18248 T18240 punct .,is
R4648 T18250 T18251 quantmod Over,30
R4649 T18251 T18252 nummod 30,QTL
R4650 T18252 T18253 nsubjpass QTL,identified
R4651 T17910 T17911 poss our,strains
R4652 T18254 T18253 aux have,identified
R4653 T18255 T18253 auxpass been,identified
R4654 T17911 T17908 nsubjpass strains,developed
R4655 T18256 T18253 prep in,identified
R4656 T18257 T18258 amod various,experiments
R4657 T18258 T18256 pobj experiments,in
R4658 T17912 T17911 compound control,strains
R4659 T18259 T18260 punct [,2
R4660 T18260 T18253 parataxis 2,identified
R4661 T17913 T17908 auxpass were,developed
R4662 T18261 T18260 nummod 1,2
R4663 T18262 T18260 punct ",",2
R4664 T17914 T17908 prep from,developed
R4665 T18263 T18260 punct ],2
R4666 T18264 T18253 punct .,identified
R4667 T17915 T17914 pobj mice,from
R4668 T18266 T18267 amod Several,QTL
R4669 T18267 T18273 nsubjpass QTL,isolated
R4670 T18268 T18269 advmod previously,reported
R4671 T17916 T17915 acl undergoing,mice
R4672 T18269 T18267 amod reported,QTL
R4673 T18270 T18269 cc or,reported
R4674 T18271 T18269 conj novel,reported
R4675 T17917 T17918 det the,selection
R4676 T18272 T18267 compound MMU2,QTL
R4677 T18274 T18273 aux have,isolated
R4678 T17918 T17916 dobj selection,undergoing
R4679 T18275 T18273 auxpass been,isolated
R4680 T18276 T18273 cc and,isolated
R4681 T17919 T17918 amod same,selection
R4682 T18277 T18273 conj characterized,isolated
R4683 T18278 T18277 advcl using,characterized
R4684 T18279 T18280 amod congenic,strains
R4685 T17920 T17918 prep as,selection
R4686 T18280 T18278 dobj strains,using
R4687 T18281 T18282 punct [,7
R4688 T18282 T18277 parataxis 7,characterized
R4689 T17921 T17920 pobj all,as
R4690 T18283 T18282 punct ",",7
R4691 T18284 T18282 appos 9,7
R4692 T18285 T18286 punct -,11
R4693 T17922 T17921 prep of,all
R4694 T18286 T18284 prep 11,9
R4695 T18287 T18282 punct ",",7
R4696 T18288 T18282 appos 36,7
R4697 T17923 T17924 det the,congenics
R4698 T18289 T18282 punct ],7
R4699 T18290 T18273 punct .,isolated
R4700 T18292 T18293 poss Our,findings
R4701 T18293 T18294 nsubj findings,are
R4702 T17924 T17922 pobj congenics,of
R4703 T18295 T18296 neg no,different
R4704 T18296 T18294 acomp different,are
R4705 T17925 T17924 amod other,congenics
R4706 T18297 T18296 cc and,different
R4707 T18298 T18296 conj indicate,different
R4708 T18299 T18300 mark that,is
R4709 T17926 T17908 punct .,developed
R4710 T18300 T18298 ccomp is,indicate
R4711 T18301 T18300 nsubj MMU2,is
R4712 T17928 T17929 advmod Therefore,is
R4713 T18302 T18303 advmod highly,complex
R4714 T17930 T17929 punct ", ",is
R4715 T17931 T17929 nsubj it,is
R4716 T17932 T17929 acomp possible,is
R4717 T18303 T18300 acomp complex,is
R4718 T17933 T17934 mark that,shared
R4719 T18304 T18300 prep with,is
R4720 T18305 T18304 pobj regards,with
R4721 T17934 T17929 ccomp shared,is
R4722 T18306 T18305 prep to,regards
R4723 T18307 T18308 nsubj genes,affecting
R4724 T18308 T18306 pcomp affecting,to
R4725 T17935 T17936 det any,QTL
R4726 T18309 T18308 dobj growth,affecting
R4727 T18310 T18309 cc and,growth
R4728 T18311 T18309 conj obesity,growth
R4729 T17936 T17934 nsubjpass QTL,shared
R4730 T17937 T17936 amod unwanted,QTL
R4731 T18312 T18294 punct .,are
R4732 T17938 T17936 cc or,QTL
R4733 T18314 T18315 det The,nature
R4734 T18315 T18317 nsubj nature,allowed
R4735 T17939 T17936 conj mutations,QTL
R4736 T18316 T18315 amod overlapping,nature
R4737 T17940 T17939 acl arising,mutations
R4738 T18318 T18315 prep of,nature
R4739 T18319 T18320 poss our,strains
R4740 T18320 T18318 pobj strains,of
R4741 T17941 T17940 prep during,arising
R4742 T18321 T18320 compound MMU2,strains
R4743 T18322 T18323 nsubj us,parse
R4744 T17942 T17943 amod congenic,construction
R4745 T18323 T18317 ccomp parse,allowed
R4746 T18324 T18323 aux to,parse
R4747 T17943 T17941 pobj construction,during
R4748 T18325 T18326 det the,chromosome
R4749 T18326 T18323 dobj chromosome,parse
R4750 T18327 T18323 prep into,parse
R4751 T18328 T18329 nummod five,regions
R4752 T18329 T18327 pobj regions,into
R4753 T17944 T17934 auxpass are,shared
R4754 T18330 T18329 punct (,regions
R4755 T18331 T18332 nmod Regions,I
R4756 T18332 T18329 appos I,regions
R4757 T17945 T17934 prep between,shared
R4758 T18333 T18334 punct –,V
R4759 T18334 T18332 prep V,I
R4760 T18335 T18317 punct ),allowed
R4761 T18336 T18337 punct (,Figure
R4762 T17946 T17947 det all,strains
R4763 T18337 T18317 parataxis Figure,allowed
R4764 T18338 T18337 nummod 2,Figure
R4765 T17947 T17945 pobj strains,between
R4766 T17948 T17929 punct .,is
R4767 T17950 T17951 advmod More,importantly
R4768 T17951 T17952 advmod importantly,have
R4769 T17953 T17952 punct ", ",have
R4770 T17954 T17952 nsubj we,have
R4771 T18339 T18337 punct ),Figure
R4772 T17955 T17952 dobj knowledge,have
R4773 T18340 T18317 punct .,allowed
R4774 T18342 T18343 det The,data
R4775 T18343 T18344 nsubj data,support
R4776 T18345 T18346 det the,presence
R4777 T18346 T18344 dobj presence,support
R4778 T18347 T18346 prep of,presence
R4779 T18348 T18349 advmod at,one
R4780 T17956 T17955 prep of,knowledge
R4781 T18349 T18351 nummod one,QTL
R4782 T18350 T18349 advmod least,one
R4783 T18351 T18347 pobj QTL,of
R4784 T18352 T18346 prep in,presence
R4785 T17957 T17958 det all,QTL
R4786 T18353 T18352 pobj each,in
R4787 T18354 T18353 prep of,each
R4788 T18355 T18356 det the,regions
R4789 T17958 T17956 pobj QTL,of
R4790 T18356 T18354 pobj regions,of
R4791 T18357 T18356 nummod five,regions
R4792 T17959 T17958 amod large,QTL
R4793 T18358 T18359 punct (,Figure
R4794 T18359 T18344 parataxis Figure,support
R4795 T18360 T18359 nummod 2,Figure
R4796 T17960 T17961 advmod previously,detected
R4797 T18361 T18359 punct ),Figure
R4798 T18362 T18344 punct .,support
R4799 T17961 T17958 amod detected,QTL
R4800 T18364 T18365 nsubj Each,impact
R4801 T17962 T17958 nmod growth,QTL
R4802 T18366 T18364 prep of,Each
R4803 T18367 T18368 det the,five
R4804 T18368 T18366 pobj five,of
R4805 T18369 T18365 advmod pleiotropically,impact
R4806 T18370 T18371 preconj both,growth
R4807 T17963 T17962 cc and,growth
R4808 T18371 T18365 dobj growth,impact
R4809 T18372 T18371 cc and,growth
R4810 T18373 T18371 conj obesity,growth
R4811 T17964 T17962 conj obesity,growth
R4812 T18374 T18365 punct ", ",impact
R4813 T18375 T18376 mark although,to
R4814 T17965 T17958 prep in,QTL
R4815 T18376 T18365 advcl to,impact
R4816 T18377 T18378 amod varying,degrees
R4817 T18378 T18376 pobj degrees,to
R4818 T17966 T17967 det the,cross
R4819 T18379 T18365 punct .,impact
R4820 T17967 T17965 pobj cross,in
R4821 T18381 T18382 prep In,adds
R4822 T18383 T18381 pobj addition,In
R4823 T17968 T17967 amod current,cross
R4824 T18384 T18383 prep to,addition
R4825 T18385 T18386 det the,number
R4826 T17969 T17970 punct [,24
R4827 T18386 T18384 pobj number,to
R4828 T18387 T18386 amod large,number
R4829 T18388 T18386 prep of,number
R4830 T17970 T17952 parataxis 24,have
R4831 T18389 T18390 compound MMU2,QTL
R4832 T18390 T18388 pobj QTL,of
R4833 T18391 T18382 punct ", ",adds
R4834 T17971 T17970 punct ],24
R4835 T17972 T17952 punct .,have
R4836 T17974 T17975 advcl Using,increased
R4837 T17976 T17977 det this,information
R4838 T18392 T18393 det the,presence
R4839 T17977 T17974 dobj information,Using
R4840 T18393 T18382 nsubj presence,adds
R4841 T18394 T18393 prep of,presence
R4842 T17978 T17975 nsubj we,increased
R4843 T18395 T18394 pobj hg,of
R4844 T18396 T18382 dobj complexity,adds
R4845 T17979 T17980 det the,density
R4846 T18397 T18382 prep by,adds
R4847 T18398 T18397 preconj either,by
R4848 T18399 T18397 conj eliciting,by
R4849 T17980 T17975 dobj density,increased
R4850 T18400 T18399 dobj interactions,eliciting
R4851 T18401 T18400 prep with,interactions
R4852 T17981 T17980 prep of,density
R4853 T18402 T18403 det the,QTL
R4854 T18403 T18401 pobj QTL,with
R4855 T18404 T18403 amod same,QTL
R4856 T18405 T18397 cc or,by
R4857 T18406 T18397 conj by,by
R4858 T17982 T17981 pobj markers,of
R4859 T18407 T18406 pcomp inducing,by
R4860 T18408 T18409 det the,expression
R4861 T18409 T18407 dobj expression,inducing
R4862 T17983 T17980 prep in,density
R4863 T18410 T18409 prep of,expression
R4864 T18411 T18412 amod novel,QTL
R4865 T18412 T18410 pobj QTL,of
R4866 T17984 T17985 det each,region
R4867 T18413 T18382 punct .,adds
R4868 T17985 T17983 pobj region,in
R4869 T18415 T18416 det The,region
R4870 T18416 T18419 nsubj region,contains
R4871 T18417 T18416 nmod 2P,region
R4872 T17986 T17985 compound QTL,region
R4873 T17987 T17988 punct (,Table
R4874 T18418 T18416 amod unique,region
R4875 T17988 T17975 parataxis Table,increased
R4876 T18420 T18416 punct (,region
R4877 T17989 T17990 nmod MMU,1
R4878 T18421 T18416 appos Region,region
R4879 T18422 T18421 nummod I,Region
R4880 T17990 T17988 dep 1,Table
R4881 T18423 T18419 punct ),contains
R4882 T18424 T18425 det an,modifier
R4883 T18425 T18419 dobj modifier,contains
R4884 T17991 T17990 punct ", ",1
R4885 T18426 T18425 compound hg,modifier
R4886 T18427 T18425 prep with,modifier
R4887 T17992 T17990 conj 2,1
R4888 T18428 T18429 amod large,effects
R4889 T18429 T18427 pobj effects,with
R4890 T17993 T17992 punct ", ",2
R4891 T18430 T18429 prep on,effects
R4892 T18431 T18430 pobj growth,on
R4893 T17994 T17992 conj 5,2
R4894 T18432 T18429 cc and,effects
R4895 T18433 T18434 amod smaller,effects
R4896 T17995 T17994 punct ", ",5
R4897 T18434 T18429 conj effects,effects
R4898 T18435 T18434 prep on,effects
R4899 T18436 T18435 pobj obesity,on
R4900 T17996 T17994 conj 8,5
R4901 T18437 T18438 punct (,Table
R4902 T18438 T18419 parataxis Table,contains
R4903 T18439 T18438 nummod 3,Table
R4904 T17997 T17996 punct ", ",8
R4905 T18440 T18438 punct ),Table
R4906 T18441 T18419 punct .,contains
R4907 T18443 T18444 prep In,affect
R4908 T17998 T17996 conj 9,8
R4909 T18445 T18443 pobj contrast,In
R4910 T18446 T18444 punct ", ",affect
R4911 T18447 T18444 nsubj interactions,affect
R4912 T17999 T17998 punct ", ",9
R4913 T18448 T18447 prep between,interactions
R4914 T18449 T18450 compound 2PM,2M
R4915 T18450 T18452 compound 2M,QTL
R4916 T18000 T17998 conj 11,9
R4917 T18451 T18450 punct /,2M
R4918 T18452 T18448 pobj QTL,between
R4919 T18001 T18000 cc and,11
R4920 T18453 T18452 cc and,QTL
R4921 T18454 T18452 conj hg,QTL
R4922 T18455 T18444 advmod primarily,affect
R4923 T18002 T18000 conj 17,11
R4924 T18456 T18457 compound fat,deposition
R4925 T18457 T18444 dobj deposition,affect
R4926 T18003 T17988 punct ;,Table
R4927 T18458 T18459 punct (,Table
R4928 T18459 T18444 parataxis Table,affect
R4929 T18460 T18459 nummod 3,Table
R4930 T18004 T17988 nummod 1,Table
R4931 T18461 T18459 punct ),Table
R4932 T18462 T18444 punct .,affect
R4933 T18005 T17988 cc and,Table
R4934 T18464 T18465 mark As,illustrated
R4935 T18465 T18466 advcl illustrated,exhibits
R4936 T18006 T18007 amod Additional,File
R4937 T18467 T18465 prep in,illustrated
R4938 T18007 T17988 conj File,Table
R4939 T18468 T18467 pobj Figure,in
R4940 T18008 T18007 nummod 1,File
R4941 T18009 T17988 punct ),Table
R4942 T18010 T17975 punct ", ",increased
R4943 T18011 T17975 advcl ensuring,increased
R4944 T18012 T18013 det the,absence
R4945 T18469 T18468 nummod 4,Figure
R4946 T18470 T18471 det the,region
R4947 T18471 T18466 nsubj region,exhibits
R4948 T18013 T18011 dobj absence,ensuring
R4949 T18472 T18471 compound 2M,region
R4950 T18473 T18471 compound donor,region
R4951 T18474 T18475 amod strong,effects
R4952 T18014 T18013 prep of,absence
R4953 T18475 T18466 dobj effects,exhibits
R4954 T18476 T18475 compound sex,effects
R4955 T18015 T18016 compound CAST,alleles
R4956 T18477 T18475 prep on,effects
R4957 T18478 T18479 det the,rate
R4958 T18016 T18014 pobj alleles,of
R4959 T18017 T18013 prep at,absence
R4960 T18018 T18017 pobj each,at
R4961 T18479 T18477 pobj rate,on
R4962 T18019 T18018 prep of,each
R4963 T18480 T18479 prep of,rate
R4964 T18481 T18482 compound lipid,storage
R4965 T18482 T18480 pobj storage,of
R4966 T18020 T18021 det these,QTL
R4967 T18483 T18466 punct ", ",exhibits
R4968 T18484 T18466 advcl dependent,exhibits
R4969 T18485 T18484 prep on,dependent
R4970 T18021 T18019 pobj QTL,of
R4971 T18486 T18485 pobj background,on
R4972 T18487 T18466 punct .,exhibits
R4973 T18022 T17975 punct .,increased
R4974 T18489 T18490 prep In,have
R4975 T18024 T18025 det This,approach
R4976 T18491 T18492 compound control,mice
R4977 T18492 T18489 pobj mice,In
R4978 T18493 T18490 punct ", ",have
R4979 T18025 T18026 nsubjpass approach,used
R4980 T18494 T18495 compound HGC,females
R4981 T18495 T18490 nsubj females,have
R4982 T18027 T18025 punct ", ",approach
R4983 T18496 T18497 det a,AI
R4984 T18497 T18490 dobj AI,have
R4985 T18498 T18497 amod higher,AI
R4986 T18499 T18497 prep than,AI
R4987 T18500 T18499 pobj males,than
R4988 T18028 T18025 acl termed,approach
R4989 T18501 T18490 punct ", ",have
R4990 T18502 T18503 mark while,seen
R4991 T18029 T18028 punct """",termed
R4992 T18503 T18490 advcl seen,have
R4993 T18504 T18505 det the,opposite
R4994 T18505 T18503 nsubjpass opposite,seen
R4995 T18030 T18031 compound QTL,Marker
R4996 T18506 T18503 auxpass is,seen
R4997 T18507 T18503 prep in,seen
R4998 T18031 T18033 npadvmod Marker,Assisted
R4999 T18508 T18509 compound B6C,mice
R5000 T18509 T18507 pobj mice,in
R5001 T18510 T18490 punct .,have
R5002 T18032 T18031 punct -,Marker
R5003 T18512 T18513 advmod Interestingly,abolished
R5004 T18033 T18035 amod Assisted,Selection
R5005 T18514 T18513 punct ", ",abolished
R5006 T18515 T18516 det the,QTL
R5007 T18034 T18033 punct -,Assisted
R5008 T18516 T18513 nsubj QTL,abolished
R5009 T18517 T18516 compound 2M,QTL
R5010 T18518 T18519 compound hg,modifier
R5011 T18519 T18516 compound modifier,QTL
R5012 T18035 T18028 oprd Selection,termed
R5013 T18520 T18521 det the,dimorphism
R5014 T18521 T18513 dobj dimorphism,abolished
R5015 T18522 T18523 npadvmod hg,induced
R5016 T18523 T18521 amod induced,dimorphism
R5017 T18036 T18035 compound Counter,Selection
R5018 T18037 T18035 punct """",Selection
R5019 T18524 T18521 amod sexual,dimorphism
R5020 T18038 T18035 cc or,Selection
R5021 T18525 T18521 prep in,dimorphism
R5022 T18526 T18525 pobj adiposity,in
R5023 T18039 T18035 conj QMACS,Selection
R5024 T18527 T18528 punct (,Figure
R5025 T18528 T18513 parataxis Figure,abolished
R5026 T18040 T18026 punct ", ",used
R5027 T18529 T18528 nummod 4,Figure
R5028 T18530 T18528 punct ),Figure
R5029 T18531 T18513 punct .,abolished
R5030 T18533 T18534 mark Although,provide
R5031 T18041 T18026 aux has,used
R5032 T18534 T18537 advcl provide,noted
R5033 T18535 T18536 det these,results
R5034 T18042 T18026 auxpass been,used
R5035 T18536 T18534 nsubj results,provide
R5036 T18043 T18026 advmod previously,used
R5037 T18538 T18534 dobj insight,provide
R5038 T18539 T18538 prep into,insight
R5039 T18540 T18541 det the,nature
R5040 T18044 T18045 aux to,characterize
R5041 T18541 T18539 pobj nature,into
R5042 T18542 T18541 prep of,nature
R5043 T18045 T18026 advcl characterize,used
R5044 T18543 T18544 compound hg,modifier
R5045 T18544 T18545 compound modifier,QTL
R5046 T18046 T18045 dobj QTL,characterize
R5047 T18545 T18542 pobj QTL,of
R5048 T18546 T18537 punct ", ",noted
R5049 T18547 T18537 nsubjpass it,noted
R5050 T18047 T18045 prep for,characterize
R5051 T18548 T18537 aux should,noted
R5052 T18549 T18537 auxpass be,noted
R5053 T18048 T18049 amod hypnotic,sensitivity
R5054 T18550 T18537 punct ", ",noted
R5055 T18551 T18552 mark that,is
R5056 T18552 T18537 ccomp is,noted
R5057 T18049 T18047 pobj sensitivity,for
R5058 T18553 T18554 det the,number
R5059 T18554 T18552 nsubj number,is
R5060 T18555 T18554 amod actual,number
R5061 T18556 T18554 cc and,number
R5062 T18557 T18558 amod precise,location
R5063 T18558 T18554 conj location,number
R5064 T18050 T18049 prep to,sensitivity
R5065 T18559 T18554 prep of,number
R5066 T18560 T18559 pobj loci,of
R5067 T18561 T18552 advmod still,is
R5068 T18051 T18050 pobj ethanol,to
R5069 T18562 T18552 acomp unclear,is
R5070 T18563 T18537 punct .,noted
R5071 T18052 T18053 punct [,31
R5072 T18565 T18566 prep In,captured
R5073 T18053 T18026 parataxis 31,used
R5074 T18567 T18565 pobj addition,In
R5075 T18054 T18053 punct ],31
R5076 T18055 T18026 punct .,used
R5077 T18057 T18058 prep In,typed
R5078 T18059 T18060 det that,study
R5079 T18060 T18057 pobj study,In
R5080 T18568 T18567 prep to,addition
R5081 T18061 T18058 punct ", ",typed
R5082 T18569 T18568 pobj MMU2,to
R5083 T18570 T18566 punct ", ",captured
R5084 T18062 T18063 advmod only,markers
R5085 T18571 T18572 nummod three,congenics
R5086 T18572 T18566 nsubj congenics,captured
R5087 T18573 T18572 amod other,congenics
R5088 T18063 T18058 nsubjpass markers,typed
R5089 T18574 T18572 punct (,congenics
R5090 T18575 T18572 appos HG9,congenics
R5091 T18064 T18063 acl flanking,markers
R5092 T18576 T18575 punct ", ",HG9
R5093 T18577 T18575 conj HG11,HG9
R5094 T18578 T18577 cc and,HG11
R5095 T18065 T18064 dobj QTL,flanking
R5096 T18579 T18577 conj HG17,HG11
R5097 T18580 T18566 punct ),captured
R5098 T18581 T18582 compound hg,modifier
R5099 T18066 T18058 auxpass were,typed
R5100 T18582 T18583 compound modifier,QTL
R5101 T18583 T18566 dobj QTL,captured
R5102 T18584 T18566 punct .,captured
R5103 T18067 T18058 punct ", ",typed
R5104 T18586 T18587 prep In,are
R5105 T18068 T18069 cc not,markers
R5106 T18588 T18589 amod classical,terms
R5107 T18589 T18586 pobj terms,In
R5108 T18069 T18058 dep markers,typed
R5109 T18590 T18587 punct ", ",are
R5110 T18591 T18587 nsubj they,are
R5111 T18070 T18071 npadvmod genome,wide
R5112 T18592 T18587 attr QTL,are
R5113 T18593 T18594 dep which,modify
R5114 T18594 T18592 relcl modify,QTL
R5115 T18595 T18596 det the,expressivity
R5116 T18596 T18594 dobj expressivity,modify
R5117 T18071 T18069 amod wide,markers
R5118 T18597 T18596 prep of,expressivity
R5119 T18598 T18597 pobj growth,of
R5120 T18599 T18598 cc and,growth
R5121 T18072 T18071 punct -,wide
R5122 T18600 T18598 conj obesity,growth
R5123 T18601 T18596 prep in,expressivity
R5124 T18073 T18058 punct .,typed
R5125 T18602 T18603 compound HG,mice
R5126 T18603 T18601 pobj mice,in
R5127 T18604 T18605 punct [,18
R5128 T18075 T18076 prep In,screened
R5129 T18605 T18587 parataxis 18,are
R5130 T18606 T18605 punct ],18
R5131 T18607 T18587 punct .,are
R5132 T18077 T18075 pobj contrast,In
R5133 T18609 T18610 det These,QTL
R5134 T18610 T18611 nsubj QTL,are
R5135 T18078 T18076 punct ", ",screened
R5136 T18612 T18611 acomp novel,are
R5137 T18613 T18614 mark since,represent
R5138 T18614 T18611 advcl represent,are
R5139 T18079 T18080 nsubj we,selected
R5140 T18615 T18614 nsubj they,represent
R5141 T18616 T18614 dobj epistasis,represent
R5142 T18080 T18076 ccomp selected,screened
R5143 T18617 T18616 prep between,epistasis
R5144 T18618 T18617 pobj hg,between
R5145 T18619 T18618 cc and,hg
R5146 T18081 T18080 preconj not,selected
R5147 T18620 T18621 det the,gene
R5148 T18621 T18618 conj gene,hg
R5149 T18622 T18621 compound modifier,gene
R5150 T18082 T18081 advmod only,not
R5151 T18623 T18611 punct .,are
R5152 T18083 T18080 conj against,selected
R5153 T18625 T18626 compound QTL,hg
R5154 T18626 T18628 compound hg,epistasis
R5155 T18627 T18626 punct -,hg
R5156 T18084 T18085 amod known,QTL
R5157 T18628 T18629 nsubj epistasis,implies
R5158 T18085 T18083 pobj QTL,against
R5159 T18086 T18076 punct ", ",screened
R5160 T18630 T18631 mark that,are
R5161 T18631 T18629 ccomp are,implies
R5162 T18087 T18076 nsubj we,screened
R5163 T18632 T18631 nsubj Socs2,are
R5164 T18633 T18632 cc and,Socs2
R5165 T18634 T18635 det the,modifiers
R5166 T18635 T18632 conj modifiers,Socs2
R5167 T18636 T18635 compound hg,modifiers
R5168 T18088 T18076 advmod also,screened
R5169 T18637 T18631 prep in,are
R5170 T18638 T18639 det the,pathway
R5171 T18639 T18637 pobj pathway,in
R5172 T18089 T18076 prep for,screened
R5173 T18640 T18639 amod same,pathway
R5174 T18641 T18639 amod biological,pathway
R5175 T18090 T18091 npadvmod genome,wide
R5176 T18642 T18629 punct .,implies
R5177 T18091 T18092 amod wide,heterozygosity
R5178 T18644 T18645 advmod Therefore,are
R5179 T18646 T18645 punct ", ",are
R5180 T18092 T18089 pobj heterozygosity,for
R5181 T18647 T18648 det these,QTL
R5182 T18648 T18645 nsubj QTL,are
R5183 T18093 T18076 advcl increasing,screened
R5184 T18649 T18645 advmod likely,are
R5185 T18650 T18645 prep due,are
R5186 T18651 T18650 pcomp to,due
R5187 T18094 T18095 det the,probability
R5188 T18652 T18650 pobj polymorphism,due
R5189 T18653 T18652 prep in,polymorphism
R5190 T18654 T18653 pobj genes,in
R5191 T18095 T18093 dobj probability,increasing
R5192 T18655 T18654 acl interacting,genes
R5193 T18656 T18655 prep with,interacting
R5194 T18096 T18097 mark that,are
R5195 T18097 T18095 acl are,probability
R5196 T18098 T18097 nsubj effects,are
R5197 T18099 T18098 acl observed,effects
R5198 T18657 T18656 pobj Gh,with
R5199 T18100 T18097 prep due,are
R5200 T18658 T18655 punct ", ",interacting
R5201 T18659 T18655 conj responsive,interacting
R5202 T18660 T18659 prep to,responsive
R5203 T18101 T18100 pcomp to,due
R5204 T18661 T18660 pobj Gh,to
R5205 T18662 T18659 cc or,responsive
R5206 T18102 T18103 amod genetic,variation
R5207 T18663 T18664 dep which,modulate
R5208 T18664 T18659 conj modulate,responsive
R5209 T18665 T18664 prep in,modulate
R5210 T18836 T18837 prep In,is
R5211 T18666 T18667 det some,way
R5212 T18667 T18665 pobj way,in
R5213 T18668 T18669 compound Gh,function
R5214 T18669 T18664 dobj function,modulate
R5215 T18670 T18645 punct .,are
R5216 T18672 T18673 det This,information
R5217 T18673 T18674 nsubj information,aid
R5218 T18675 T18674 aux will,aid
R5219 T18676 T18674 advmod significantly,aid
R5220 T18677 T18678 compound QTL,cloning
R5221 T18678 T18674 dobj cloning,aid
R5222 T18679 T18674 prep by,aid
R5223 T18680 T18679 pcomp providing,by
R5224 T18681 T18682 det another,filter
R5225 T18682 T18680 dobj filter,providing
R5226 T18683 T18684 aux to,screen
R5227 T18684 T18682 advcl screen,filter
R5228 T18685 T18684 dobj candidates,screen
R5229 T18686 T18674 punct .,aid
R5230 T18688 T18689 amod Cloning,QTL
R5231 T18689 T18691 nsubj QTL,has
R5232 T18690 T18689 det these,QTL
R5233 T18692 T18693 amod major,implications
R5234 T18693 T18691 dobj implications,has
R5235 T18694 T18695 aux to,improve
R5236 T18695 T18693 advcl improve,implications
R5237 T18696 T18697 poss our,understanding
R5238 T18838 T18836 pobj contrast,In
R5239 T18697 T18695 dobj understanding,improve
R5240 T18698 T18697 prep of,understanding
R5241 T18699 T18698 pobj Gh,of
R5242 T18700 T18699 cc and,Gh
R5243 T18701 T18702 poss its,regulation
R5244 T18702 T18699 conj regulation,Gh
R5245 T18839 T18837 punct ", ",is
R5246 T18703 T18702 prep of,regulation
R5247 T18704 T18703 pobj growth,of
R5248 T18840 T18841 det the,strain
R5249 T18705 T18704 cc and,growth
R5250 T18706 T18704 conj adiposity,growth
R5251 T18707 T18695 cc and,improve
R5252 T18841 T18837 nsubj strain,is
R5253 T18708 T18695 conj in,improve
R5254 T18709 T18710 det the,administration
R5255 T18842 T18841 compound HG9,strain
R5256 T18710 T18708 pobj administration,in
R5257 T18711 T18710 prep of,administration
R5258 T18712 T18713 amod human,Gh
R5259 T18843 T18844 det an,model
R5260 T18713 T18714 compound Gh,therapeutics
R5261 T18714 T18711 pobj therapeutics,of
R5262 T18715 T18691 punct .,has
R5263 T18844 T18837 attr model,is
R5264 T18717 T18718 compound HG1,mice
R5265 T18845 T18846 amod obese,mouse
R5266 T18718 T18719 nsubj mice,displayed
R5267 T18720 T18719 dobj differences,displayed
R5268 T18846 T18844 compound mouse,model
R5269 T18721 T18722 advmod only,in
R5270 T18722 T18720 prep in,differences
R5271 T18723 T18724 compound growth,traits
R5272 T18724 T18722 pobj traits,in
R5273 T18725 T18719 punct .,displayed
R5274 T18847 T18837 punct .,is
R5275 T18727 T18728 advmod Originally,had
R5276 T18849 T18850 det The,strain
R5277 T18729 T18728 punct ", ",had
R5278 T18730 T18728 nsubj Q1Ucd1,had
R5279 T18731 T18732 amod small,effects
R5280 T18732 T18728 dobj effects,had
R5281 T18850 T18851 nsubj strain,is
R5282 T18733 T18728 cc and,had
R5283 T18734 T18735 det these,results
R5284 T18852 T18853 advmod quite,novel
R5285 T18735 T18736 nsubj results,illustrate
R5286 T18853 T18851 acomp novel,is
R5287 T18736 T18728 conj illustrate,had
R5288 T18854 T18851 prep for,is
R5289 T18737 T18738 det the,power
R5290 T18738 T18736 dobj power,illustrate
R5291 T18739 T18738 prep of,power
R5292 T18740 T18741 amod congenic,strain
R5293 T18855 T18856 nummod two,reasons
R5294 T18856 T18854 pobj reasons,for
R5295 T18857 T18851 punct .,is
R5296 T18741 T18742 compound strain,analysis
R5297 T18859 T18860 advmod First,was
R5298 T18742 T18739 pobj analysis,of
R5299 T18743 T18744 aux to,isolate
R5300 T18861 T18860 punct ", ",was
R5301 T18744 T18738 acl isolate,power
R5302 T18745 T18746 amod small,effect
R5303 T18862 T18863 det the,size
R5304 T18863 T18865 nsubj size,is
R5305 T18864 T18863 compound effect,size
R5306 T18865 T18860 ccomp is,was
R5307 T18746 T18747 compound effect,QTL
R5308 T18866 T18865 acomp large,is
R5309 T18747 T18744 dobj QTL,isolate
R5310 T18867 T18860 punct ;,was
R5311 T18748 T18736 punct ", ",illustrate
R5312 T18749 T18750 mark although,is
R5313 T18750 T18736 advcl is,illustrate
R5314 T18868 T18860 nsubj AI,was
R5315 T18751 T18750 nsubj it,is
R5316 T18752 T18750 acomp likely,is
R5317 T18869 T18870 nummod 57,%
R5318 T18753 T18754 det this,QTL
R5319 T18754 T18755 nsubj QTL,represents
R5320 T18755 T18752 advcl represents,likely
R5321 T18756 T18757 det the,boundary
R5322 T18757 T18755 dobj boundary,represents
R5323 T18870 T18871 npadvmod %,higher
R5324 T18758 T18757 amod lower,boundary
R5325 T18759 T18757 prep of,boundary
R5326 T18760 T18759 pobj detection,of
R5327 T18871 T18860 acomp higher,was
R5328 T18761 T18757 acl using,boundary
R5329 T18762 T18763 advmod only,30
R5330 T18872 T18871 prep in,higher
R5331 T18763 T18766 nummod 30,mice
R5332 T18764 T18763 quantmod 20,30
R5333 T18765 T18763 punct –,30
R5334 T18873 T18874 compound HG9,females
R5335 T18766 T18761 dobj mice,using
R5336 T18767 T18766 amod congenic,mice
R5337 T18768 T18736 punct .,illustrate
R5338 T18874 T18872 pobj females,in
R5339 T18770 T18771 det The,genes
R5340 T18771 T18775 nsubj genes,are
R5341 T18875 T18871 cc and,higher
R5342 T18772 T18773 advmod most,notable
R5343 T18773 T18771 amod notable,genes
R5344 T18774 T18771 compound candidate,genes
R5345 T18876 T18877 nummod 30,%
R5346 T18776 T18771 acl located,genes
R5347 T18877 T18878 npadvmod %,higher
R5348 T18777 T18776 prep within,located
R5349 T18778 T18779 det the,interval
R5350 T18878 T18871 conj higher,higher
R5351 T18779 T18777 pobj interval,within
R5352 T18780 T18779 compound HG1,interval
R5353 T18879 T18878 prep in,higher
R5354 T18781 T18782 det the,transducer
R5355 T18782 T18775 attr transducer,are
R5356 T18783 T18782 compound signal,transducer
R5357 T18880 T18879 pobj males,in
R5358 T18784 T18782 cc and,transducer
R5359 T18785 T18782 conj activator,transducer
R5360 T18881 T18860 punct .,was
R5361 T18786 T18785 prep of,activator
R5362 T18787 T18786 pobj transcription,of
R5363 T18788 T18787 nummod 1,transcription
R5364 T18883 T18884 advmod Secondly,is
R5365 T18789 T18787 punct (,transcription
R5366 T18790 T18787 appos Stat1,transcription
R5367 T18791 T18787 punct ),transcription
R5368 T18885 T18884 punct ", ",is
R5369 T18792 T18787 cc and,transcription
R5370 T18793 T18787 conj Stat4,transcription
R5371 T18794 T18775 punct .,are
R5372 T18886 T18884 nsubj it,is
R5373 T18796 T18797 nsubj Two,had
R5374 T18798 T18796 prep of,Two
R5375 T18799 T18800 det the,congenics
R5376 T18800 T18798 pobj congenics,of
R5377 T18887 T18884 acomp dependent,is
R5378 T18801 T18802 amod major,alterations
R5379 T18802 T18797 dative alterations,had
R5380 T18888 T18887 prep on,dependent
R5381 T18803 T18802 prep in,alterations
R5382 T18804 T18805 det the,deposition
R5383 T18805 T18803 pobj deposition,in
R5384 T18889 T18888 pobj hg,on
R5385 T18806 T18805 prep of,deposition
R5386 T18807 T18808 compound adipose,tissue
R5387 T18808 T18806 pobj tissue,of
R5388 T18890 T18884 prep for,is
R5389 T18809 T18797 punct ", ",had
R5390 T18810 T18797 dobj HG8,had
R5391 T18811 T18810 cc and,HG8
R5392 T18891 T18892 poss its,expression
R5393 T18812 T18810 conj HG9,HG8
R5394 T18813 T18797 punct .,had
R5395 T18892 T18890 pobj expression,for
R5396 T18815 T18816 det The,region
R5397 T18893 T18884 punct .,is
R5398 T18816 T18819 nsubj region,promotes
R5399 T18817 T18816 compound HG8,region
R5400 T18895 T18896 det The,strain
R5401 T18818 T18816 compound donor,region
R5402 T18820 T18819 dobj leanness,promotes
R5403 T18821 T18819 punct .,promotes
R5404 T18896 T18898 nsubj strain,represents
R5405 T18823 T18824 amod Congenic,females
R5406 T18897 T18896 compound HG9,strain
R5407 T18824 T18825 nsubj females,displayed
R5408 T18826 T18827 det a,reduction
R5409 T18899 T18900 det a,model
R5410 T18827 T18825 dobj reduction,displayed
R5411 T18828 T18827 prep of,reduction
R5412 T18829 T18830 quantmod over,25
R5413 T18900 T18898 dobj model,represents
R5414 T18830 T18831 nummod 25,%
R5415 T18831 T18828 pobj %,of
R5416 T18901 T18900 amod major,model
R5417 T18832 T18827 prep in,reduction
R5418 T18833 T18832 pobj AI,in
R5419 T18834 T18825 punct .,displayed
R5420 T18902 T18903 npadvmod epistasis,based
R5421 T18903 T18900 amod based,model
R5422 T18904 T18903 punct -,based
R5423 T18905 T18906 amod obese,mouse
R5424 T18906 T18900 compound mouse,model
R5425 T18907 T18898 cc and,represents
R5426 T18908 T18898 conj promises,represents
R5427 T18909 T18910 aux to,aid
R5428 T18910 T18908 xcomp aid,promises
R5429 T18911 T18910 prep in,aid
R5430 T18912 T18913 det the,understanding
R5431 T18913 T18911 pobj understanding,in
R5432 T18914 T18913 prep of,understanding
R5433 T18915 T18914 pobj obesity,of
R5434 T19201 T19202 npadvmod sex,specific
R5435 T18916 T18913 cc and,understanding
R5436 T19202 T19200 amod specific,phenotypes
R5437 T19203 T19202 punct -,specific
R5438 T18917 T18918 advmod specifically,modulation
R5439 T19204 T19200 prep in,phenotypes
R5440 T19205 T19206 compound HG11,mice
R5441 T19206 T19204 pobj mice,in
R5442 T18918 T18913 conj modulation,understanding
R5443 T19207 T19208 mark since,is
R5444 T19208 T19192 advcl is,explain
R5445 T18919 T18918 det the,modulation
R5446 T19209 T19208 nsubj it,is
R5447 T19210 T19211 det the,factor
R5448 T19211 T19208 attr factor,is
R5449 T18920 T18918 prep of,modulation
R5450 T19212 T19211 amod primary,factor
R5451 T19213 T19211 compound transcription,factor
R5452 T19214 T19211 amod responsible,factor
R5453 T18921 T18922 compound adipose,tissue
R5454 T19215 T19214 prep for,responsible
R5455 T19216 T19217 npadvmod Gh,induced
R5456 T19217 T19218 amod induced,expression
R5457 T18922 T18923 compound tissue,deposition
R5458 T19218 T19215 pobj expression,for
R5459 T19219 T19220 npadvmod sex,specific
R5460 T19220 T19218 amod specific,expression
R5461 T18923 T18920 pobj deposition,of
R5462 T19221 T19220 punct -,specific
R5463 T19222 T19223 compound liver,gene
R5464 T18924 T18918 prep by,modulation
R5465 T19223 T19218 compound gene,expression
R5466 T19224 T19225 punct [,44
R5467 T19225 T19192 parataxis 44,explain
R5468 T18925 T18924 pobj Gh,by
R5469 T19226 T19225 punct ],44
R5470 T19227 T19192 punct .,explain
R5471 T18926 T18898 punct .,represents
R5472 T19229 T19230 amod Future,studies
R5473 T19230 T19231 nsubj studies,include
R5474 T19232 T19230 acl aimed,studies
R5475 T19233 T19232 prep at,aimed
R5476 T19234 T19233 pcomp identifying,at
R5477 T19235 T19236 det the,QTG
R5478 T19236 T19234 dobj QTG,identifying
R5479 T19237 T19236 compound HG11,QTG
R5480 T19238 T19231 punct ", ",include
R5481 T19239 T19231 aux will,include
R5482 T19240 T19231 advmod certainly,include
R5483 T19241 T19242 det a,characterization
R5484 T18928 T18929 nsubj Studies,are
R5485 T19242 T19231 dobj characterization,include
R5486 T19243 T19242 amod thorough,characterization
R5487 T19244 T19242 prep of,characterization
R5488 T19245 T19246 nmod Gh,patterns
R5489 T18930 T18929 advmod currently,are
R5490 T19246 T19244 pobj patterns,of
R5491 T19247 T19245 cc and,Gh
R5492 T19248 T19245 conj Stat5b,Gh
R5493 T19249 T19246 nmod sequence,patterns
R5494 T18931 T18929 acomp underway,are
R5495 T19250 T19249 cc and,sequence
R5496 T19251 T19249 conj expression,sequence
R5497 T18932 T18933 aux to,identify
R5498 T19252 T19246 prep in,patterns
R5499 T19253 T19254 amod congenic,mice
R5500 T19254 T19252 pobj mice,in
R5501 T18933 T18929 advcl identify,are
R5502 T19255 T19231 punct .,include
R5503 T18934 T18935 det the,mutation
R5504 T19257 T19258 det The,QTL
R5505 T19258 T19261 nsubj QTL,had
R5506 T19259 T19260 compound hg,modifier
R5507 T18935 T18933 dobj mutation,identify
R5508 T19260 T19258 compound modifier,QTL
R5509 T19262 T19258 acl located,QTL
R5510 T18936 T18935 amod causative,mutation
R5511 T19263 T19262 prep within,located
R5512 T19264 T19265 det the,strain
R5513 T19265 T19263 pobj strain,within
R5514 T18937 T18933 cc and,identify
R5515 T18938 T18939 aux to,characterize
R5516 T19266 T19265 compound HG17,strain
R5517 T18939 T18933 conj characterize,identify
R5518 T19267 T19268 amod large,effects
R5519 T19268 T19261 dobj effects,had
R5520 T18940 T18941 det the,effects
R5521 T19269 T19268 prep on,effects
R5522 T19270 T19269 pobj growth,on
R5523 T19271 T19270 punct ", ",growth
R5524 T18941 T18939 dobj effects,characterize
R5525 T19272 T19273 compound body,length
R5526 T19273 T19270 conj length,growth
R5527 T18942 T18941 prep of,effects
R5528 T19274 T19273 cc and,length
R5529 T19275 T19276 compound carcass,components
R5530 T18943 T18942 pobj age,of
R5531 T18944 T18943 cc and,age
R5532 T18945 T18943 conj diet,age
R5533 T19276 T19273 conj components,length
R5534 T18946 T18941 prep on,effects
R5535 T19277 T19261 punct .,had
R5536 T18947 T18946 pobj obesity,on
R5537 T19279 T19280 det The,gene
R5538 T18948 T18947 prep in,obesity
R5539 T19280 T19284 nsubj gene,is
R5540 T19281 T19282 advmod most,intriguing
R5541 T19282 T19280 amod intriguing,gene
R5542 T18949 T18950 det this,strain
R5543 T19283 T19280 compound candidate,gene
R5544 T18950 T18948 pobj strain,in
R5545 T19285 T19280 acl located,gene
R5546 T19286 T19285 prep in,located
R5547 T19287 T19288 det the,congenic
R5548 T18951 T18952 advmod as,as
R5549 T19288 T19286 pobj congenic,in
R5550 T19289 T19284 attr Sstr5,is
R5551 T19290 T19284 punct .,is
R5552 T18952 T18941 cc as,effects
R5553 T19292 T19293 nsubj Somatostatin,is
R5554 T18953 T18952 advmod well,as
R5555 T19294 T19295 det a,inhibitor
R5556 T18954 T18941 conj testing,effects
R5557 T19295 T19293 attr inhibitor,is
R5558 T19296 T19295 amod potent,inhibitor
R5559 T18955 T18954 prep for,testing
R5560 T19297 T19295 prep of,inhibitor
R5561 T19298 T19297 pobj Gh,of
R5562 T19299 T19293 cc and,is
R5563 T18956 T18957 amod other,consequences
R5564 T19300 T19301 nsubj Sstr5,is
R5565 T19301 T19293 conj is,is
R5566 T19302 T19301 attr one,is
R5567 T18957 T18955 pobj consequences,for
R5568 T19303 T19302 prep of,one
R5569 T19304 T19305 nummod five,receptors
R5570 T18958 T18957 amod physiological,consequences
R5571 T19305 T19303 pobj receptors,of
R5572 T19306 T19307 dep which,mediate
R5573 T19307 T19305 relcl mediate,receptors
R5574 T18959 T18960 amod such,as
R5575 T19308 T19309 det these,effects
R5576 T19309 T19307 dobj effects,mediate
R5577 T18960 T18957 prep as,consequences
R5578 T19310 T19311 punct [,46
R5579 T19311 T19301 parataxis 46,is
R5580 T19312 T19311 nummod 45,46
R5581 T19313 T19311 punct ",",46
R5582 T19314 T19311 punct ],46
R5583 T19315 T19301 punct .,is
R5584 T18961 T18960 pobj alterations,as
R5585 T19317 T19318 amod Ubiquitous,knockout
R5586 T18962 T18961 prep in,alterations
R5587 T19318 T19324 nsubj knockout,leads
R5588 T19319 T19317 cc and,Ubiquitous
R5589 T19320 T19321 amod pancreatic,cell
R5590 T18963 T18964 compound food,intake
R5591 T19321 T19323 npadvmod cell,specific
R5592 T19322 T19321 compound beta,cell
R5593 T19323 T19317 conj specific,Ubiquitous
R5594 T18964 T18962 pobj intake,in
R5595 T19325 T19318 prep of,knockout
R5596 T19326 T19325 pobj Sstr5,of
R5597 T18965 T18964 cc and,intake
R5598 T19327 T19324 prep to,leads
R5599 T19328 T19327 pobj alterations,to
R5600 T18966 T18967 compound insulin,sensitivity
R5601 T19329 T19328 prep in,alterations
R5602 T19330 T19331 compound insulin,secretion
R5603 T19331 T19329 pobj secretion,in
R5604 T18967 T18964 conj sensitivity,intake
R5605 T19332 T19331 cc and,secretion
R5606 T19333 T19334 compound glucose,homeostasis
R5607 T18968 T18929 punct .,are
R5608 T19334 T19331 conj homeostasis,secretion
R5609 T19335 T19336 punct [,48
R5610 T19336 T19324 parataxis 48,leads
R5611 T18970 T18971 det The,strain
R5612 T19337 T19336 nummod 47,48
R5613 T19338 T19336 punct ",",48
R5614 T19339 T19336 punct ],48
R5615 T19340 T19324 punct .,leads
R5616 T18971 T18973 nsubj strain,is
R5617 T19342 T19343 nsubj We,sequenced
R5618 T18972 T18971 compound HG11,strain
R5619 T19344 T19345 compound candidate,genes
R5620 T19345 T19343 dobj genes,sequenced
R5621 T18974 T18973 prep of,is
R5622 T19346 T19347 compound hg,modifier
R5623 T19347 T19345 compound modifier,genes
R5624 T19348 T19349 aux to,complement
R5625 T19349 T19343 advcl complement,sequenced
R5626 T18975 T18976 amod particular,interest
R5627 T19350 T19351 det the,characterization
R5628 T19351 T19349 dobj characterization,complement
R5629 T18976 T18974 pobj interest,of
R5630 T19352 T19351 prep of,characterization
R5631 T19353 T19354 det the,congenics
R5632 T19354 T19352 pobj congenics,of
R5633 T19355 T19354 compound speed,congenics
R5634 T19356 T19354 prep on,congenics
R5635 T19357 T19358 nmod MMU,2
R5636 T18977 T18973 prep for,is
R5637 T19358 T19356 pobj 2,on
R5638 T19359 T19358 punct ", ",2
R5639 T19360 T19358 conj 9,2
R5640 T18978 T18979 det a,number
R5641 T19361 T19360 punct ", ",9
R5642 T19362 T19360 conj 11,9
R5643 T18979 T18977 pobj number,for
R5644 T19363 T19362 cc and,11
R5645 T19364 T19362 conj 17,11
R5646 T18980 T18979 prep of,number
R5647 T18981 T18980 pobj reasons,of
R5648 T18982 T18973 punct .,is
R5649 T18984 T18985 advmod First,demonstrated
R5650 T19365 T19343 punct .,sequenced
R5651 T18986 T18985 punct ", ",demonstrated
R5652 T19367 T19368 det A,number
R5653 T19368 T19370 nsubj number,identified
R5654 T19369 T19368 amod limited,number
R5655 T18987 T18988 npadvmod HG11,congenic
R5656 T19371 T19368 prep of,number
R5657 T18988 T18989 amod congenic,mice
R5658 T18989 T18985 nsubj mice,demonstrated
R5659 T19372 T19371 pobj studies,of
R5660 T19373 T19370 aux have,identified
R5661 T18990 T18991 amod significant,interactions
R5662 T19374 T19370 dobj variation,identified
R5663 T19375 T19374 prep within,variation
R5664 T18991 T18985 dobj interactions,demonstrated
R5665 T19376 T19377 compound CAST,sequence
R5666 T19377 T19375 pobj sequence,within
R5667 T19378 T19377 compound coding,sequence
R5668 T18992 T18991 nmod strain,interactions
R5669 T19379 T19370 punct ;,identified
R5670 T19380 T19370 cc so,identified
R5671 T18993 T18992 prep by,strain
R5672 T19381 T19382 amod sequencing,candidates
R5673 T19382 T19383 nsubj candidates,gave
R5674 T19383 T19370 conj gave,identified
R5675 T18994 T18993 pobj sex,by
R5676 T19384 T19383 dative us,gave
R5677 T19385 T19386 det the,opportunity
R5678 T18995 T18985 prep for,demonstrated
R5679 T19386 T19383 dobj opportunity,gave
R5680 T19387 T19388 aux to,estimate
R5681 T18996 T18997 det a,number
R5682 T19388 T19386 acl estimate,opportunity
R5683 T19389 T19390 det the,frequency
R5684 T19390 T19388 dobj frequency,estimate
R5685 T19391 T19390 compound SNP,frequency
R5686 T19392 T19390 prep in,frequency
R5687 T18997 T18995 pobj number,for
R5688 T19393 T19394 compound coding,sequence
R5689 T19394 T19392 pobj sequence,in
R5690 T19395 T19388 advcl relative,estimate
R5691 T18998 T18997 prep of,number
R5692 T19396 T19395 prep to,relative
R5693 T19397 T19396 pobj B6,to
R5694 T19398 T19383 punct .,gave
R5695 T18999 T18998 pobj traits,of
R5696 T19400 T19401 det This,information
R5697 T19000 T18985 punct .,demonstrated
R5698 T19401 T19402 nsubj information,be
R5699 T19403 T19402 aux will,be
R5700 T19002 T19003 nsubj Males,were
R5701 T19404 T19402 acomp vital,be
R5702 T19405 T19404 prep to,vital
R5703 T19406 T19407 amod future,studies
R5704 T19004 T19005 advmod generally,larger
R5705 T19407 T19405 pobj studies,to
R5706 T19408 T19409 amod fine,mapping
R5707 T19409 T19407 compound mapping,studies
R5708 T19410 T19407 punct ", ",studies
R5709 T19005 T19003 acomp larger,were
R5710 T19411 T19412 dep which,include
R5711 T19412 T19407 relcl include,studies
R5712 T19413 T19412 aux will,include
R5713 T19006 T19005 punct ", ",larger
R5714 T19414 T19415 compound gene,expression
R5715 T19415 T19416 compound expression,analysis
R5716 T19416 T19412 dobj analysis,include
R5717 T19007 T19008 amod faster,growing
R5718 T19417 T19402 punct .,be
R5719 T19008 T19005 conj growing,larger
R5720 T19419 T19420 det The,frequency
R5721 T19420 T19423 nsubj frequency,lead
R5722 T19421 T19420 amod high,frequency
R5723 T19009 T19008 cc and,growing
R5724 T19422 T19420 compound SNP,frequency
R5725 T19424 T19425 punct (,SNP
R5726 T19010 T19008 conj longer,growing
R5727 T19425 T19420 parataxis SNP,frequency
R5728 T19426 T19427 nummod 0.312,%
R5729 T19427 T19425 dep %,SNP
R5730 T19011 T19003 cc and,were
R5731 T19428 T19425 punct ;,SNP
R5732 T19429 T19425 nummod 295,SNP
R5733 T19012 T19013 det the,converse
R5734 T19430 T19425 prep in,SNP
R5735 T19431 T19432 nummod 94.492,kbp
R5736 T19432 T19430 pobj kbp,in
R5737 T19433 T19425 punct ),SNP
R5738 T19434 T19420 prep in,frequency
R5739 T19435 T19436 compound CAST,genes
R5740 T19013 T19014 nsubjpass converse,seen
R5741 T19436 T19434 pobj genes,in
R5742 T19437 T19423 aux may,lead
R5743 T19438 T19423 prep to,lead
R5744 T19014 T19003 conj seen,were
R5745 T19439 T19440 det a,rate
R5746 T19440 T19438 pobj rate,to
R5747 T19441 T19440 amod higher,rate
R5748 T19442 T19440 prep of,rate
R5749 T19443 T19444 amod false,positives
R5750 T19444 T19442 pobj positives,of
R5751 T19445 T19444 acl using,positives
R5752 T19446 T19447 compound DNA,microarrays
R5753 T19447 T19445 dobj microarrays,using
R5754 T19448 T19447 cc or,microarrays
R5755 T19015 T19014 auxpass was,seen
R5756 T19449 T19450 amod quantitative,assays
R5757 T19016 T19014 prep in,seen
R5758 T19017 T19016 pobj females,in
R5759 T19018 T19014 punct .,seen
R5760 T19020 T19021 det The,effects
R5761 T19450 T19447 conj assays,microarrays
R5762 T19021 T19023 nsubj effects,are
R5763 T19451 T19452 amod real,time
R5764 T19452 T19450 compound time,assays
R5765 T19453 T19452 punct -,time
R5766 T19022 T19021 amod confounding,effects
R5767 T19454 T19450 compound PCR,assays
R5768 T19455 T19447 punct ", ",microarrays
R5769 T19024 T19021 prep of,effects
R5770 T19456 T19457 dep most,based
R5771 T19457 T19447 relcl based,microarrays
R5772 T19458 T19456 prep of,most
R5773 T19459 T19458 pobj which,of
R5774 T19025 T19024 pobj sex,of
R5775 T19460 T19457 auxpass are,based
R5776 T19461 T19457 prep on,based
R5777 T19462 T19463 compound B6,sequence
R5778 T19026 T19023 advmod likely,are
R5779 T19463 T19461 pobj sequence,on
R5780 T19464 T19423 punct .,lead
R5781 T19027 T19028 det the,reason
R5782 T19466 T19467 advmod Therefore,used
R5783 T19028 T19023 attr reason,are
R5784 T19468 T19467 punct ", ",used
R5785 T19469 T19470 det these,data
R5786 T19470 T19467 nsubjpass data,used
R5787 T19029 T19028 prep for,reason
R5788 T19471 T19470 compound sequence,data
R5789 T19472 T19467 aux can,used
R5790 T19473 T19467 auxpass be,used
R5791 T19474 T19475 aux to,guide
R5792 T19475 T19467 advcl guide,used
R5793 T19476 T19477 det the,development
R5794 T19030 T19031 det the,discrepancies
R5795 T19477 T19475 dobj development,guide
R5796 T19031 T19029 pobj discrepancies,for
R5797 T19032 T19031 prep between,discrepancies
R5798 T19478 T19477 prep of,development
R5799 T19479 T19480 compound gene,expression
R5800 T19480 T19481 compound expression,assays
R5801 T19033 T19034 det the,results
R5802 T19481 T19478 pobj assays,of
R5803 T19482 T19483 aux to,confirm
R5804 T19034 T19032 pobj results,between
R5805 T19483 T19475 advcl confirm,guide
R5806 T19484 T19485 amod differential,expression
R5807 T19485 T19483 dobj expression,confirm
R5808 T19035 T19036 amod congenic,genome
R5809 T19486 T19483 prep for,confirm
R5810 T19487 T19486 pobj candidates,for
R5811 T19036 T19038 compound genome,scan
R5812 T19488 T19467 cc and,used
R5813 T19489 T19467 conj suggests,used
R5814 T19037 T19036 cc and,genome
R5815 T19490 T19491 mark that,sequenced
R5816 T19491 T19489 ccomp sequenced,suggests
R5817 T19492 T19491 nsubjpass genes,sequenced
R5818 T19493 T19492 acl identified,genes
R5819 T19038 T19034 compound scan,results
R5820 T19494 T19493 prep by,identified
R5821 T19495 T19496 amod downstream,experiments
R5822 T19039 T19034 punct ", ",results
R5823 T19496 T19494 pobj experiments,by
R5824 T19497 T19491 aux should,sequenced
R5825 T19498 T19491 advmod also,sequenced
R5826 T19040 T19041 advmod where,analyzed
R5827 T19499 T19491 auxpass be,sequenced
R5828 T19500 T19467 punct .,used
R5829 T19041 T19034 relcl analyzed,results
R5830 T19502 T19503 advmod More,importantly
R5831 T19503 T19504 advmod importantly,allowed
R5832 T19042 T19043 det both,sexes
R5833 T19505 T19504 punct ", ",allowed
R5834 T19506 T19504 csubj sequencing,allowed
R5835 T19043 T19041 nsubjpass sexes,analyzed
R5836 T19507 T19508 compound hg,modifier
R5837 T19508 T19509 compound modifier,candidates
R5838 T19509 T19506 dobj candidates,sequencing
R5839 T19044 T19041 auxpass were,analyzed
R5840 T19510 T19511 nsubj us,identify
R5841 T19511 T19504 ccomp identify,allowed
R5842 T19512 T19511 aux to,identify
R5843 T19513 T19514 amod nonsynonomous,polymorphism
R5844 T19514 T19511 dobj polymorphism,identify
R5845 T19515 T19514 punct ", ",polymorphism
R5846 T19045 T19041 advmod together,analyzed
R5847 T19516 T19517 dep which,underlie
R5848 T19517 T19514 relcl underlie,polymorphism
R5849 T19518 T19517 aux may,underlie
R5850 T19046 T19023 punct .,are
R5851 T19519 T19517 dobj QTL,underlie
R5852 T19520 T19504 punct .,allowed
R5853 T19048 T19049 advmod Secondly,found
R5854 T19522 T19523 nsubj SIFT,predicted
R5855 T19524 T19522 cc and,SIFT
R5856 T19525 T19524 punct /,and
R5857 T19050 T19049 punct ", ",found
R5858 T19526 T19524 cc or,and
R5859 T19527 T19522 conj PolyPhen,SIFT
R5860 T19528 T19523 dobj alterations,predicted
R5861 T19529 T19528 prep in,alterations
R5862 T19051 T19049 nsubjpass Carp2,found
R5863 T19530 T19531 compound protein,function
R5864 T19531 T19529 pobj function,in
R5865 T19052 T19049 auxpass was,found
R5866 T19532 T19528 prep for,alterations
R5867 T19533 T19532 pobj 15,for
R5868 T19534 T19533 prep of,15
R5869 T19053 T19054 aux to,interact
R5870 T19535 T19536 det the,nsSNP
R5871 T19536 T19534 pobj nsSNP,of
R5872 T19054 T19049 xcomp interact,found
R5873 T19055 T19054 prep with,interact
R5874 T19056 T19055 pobj hg,with
R5875 T19057 T19049 cc and,found
R5876 T19058 T19059 nsubjpass MMU11,saturated
R5877 T19537 T19536 nummod 56,nsSNP
R5878 T19538 T19536 amod total,nsSNP
R5879 T19059 T19049 conj saturated,found
R5880 T19060 T19059 auxpass is,saturated
R5881 T19061 T19059 prep with,saturated
R5882 T19062 T19061 pobj genes,with
R5883 T19063 T19062 acl involved,genes
R5884 T19539 T19540 punct (,%
R5885 T19064 T19063 prep in,involved
R5886 T19540 T19533 parataxis %,15
R5887 T19541 T19540 nummod 27,%
R5888 T19065 T19066 det the,pathway
R5889 T19542 T19540 punct ),%
R5890 T19543 T19533 prep in,15
R5891 T19066 T19064 pobj pathway,in
R5892 T19544 T19543 pobj nine,in
R5893 T19545 T19544 prep of,nine
R5894 T19546 T19547 det the,genes
R5895 T19547 T19545 pobj genes,of
R5896 T19548 T19547 nummod 44,genes
R5897 T19067 T19066 amod central,pathway
R5898 T19549 T19547 amod total,genes
R5899 T19550 T19551 punct (,%
R5900 T19551 T19543 parataxis %,in
R5901 T19068 T19066 nmod Gh,pathway
R5902 T19552 T19551 nummod 20,%
R5903 T19553 T19551 punct ),%
R5904 T19069 T19066 amod intracellular,pathway
R5905 T19554 T19555 punct (,Table
R5906 T19555 T19523 parataxis Table,predicted
R5907 T19556 T19555 nummod 7,Table
R5908 T19070 T19066 compound signaling,pathway
R5909 T19557 T19555 punct ),Table
R5910 T19558 T19523 punct .,predicted
R5911 T19071 T19062 punct ", ",genes
R5912 T19560 T19561 nsubjpass It,shown
R5913 T19072 T19073 amod such,as
R5914 T19562 T19561 aux has,shown
R5915 T19563 T19561 auxpass been,shown
R5916 T19073 T19062 prep as,genes
R5917 T19564 T19565 mark that,is
R5918 T19565 T19561 ccomp is,shown
R5919 T19566 T19565 csubj predicting,is
R5920 T19074 T19073 pobj Gh,as
R5921 T19075 T19074 punct ", ",Gh
R5922 T19076 T19074 conj Stat5b,Gh
R5923 T19077 T19076 cc and,Stat5b
R5924 T19567 T19566 dobj function,predicting
R5925 T19568 T19566 prep based,predicting
R5926 T19078 T19076 conj Stat5a,Stat5b
R5927 T19569 T19568 prep on,based
R5928 T19570 T19571 amod evolutionary,conservation
R5929 T19571 T19569 pobj conservation,on
R5930 T19079 T19049 punct .,found
R5931 T19572 T19566 advcl using,predicting
R5932 T19573 T19572 dobj programs,using
R5933 T19574 T19575 amod such,as
R5934 T19081 T19082 advmod Thirdly,identified
R5935 T19575 T19573 prep as,programs
R5936 T19576 T19575 pobj SIFT,as
R5937 T19577 T19576 cc and,SIFT
R5938 T19083 T19082 punct ", ",identified
R5939 T19578 T19576 conj PolyPhen,SIFT
R5940 T19579 T19580 advmod very,accurate
R5941 T19580 T19565 acomp accurate,is
R5942 T19581 T19582 punct [,49
R5943 T19084 T19085 compound MMU11,QTL
R5944 T19582 T19561 parataxis 49,shown
R5945 T19583 T19582 punct ],49
R5946 T19085 T19082 nsubjpass QTL,identified
R5947 T19584 T19561 punct .,shown
R5948 T19586 T19587 nsubj Four,are
R5949 T19086 T19085 compound growth,QTL
R5950 T19588 T19586 prep of,Four
R5951 T19589 T19590 det the,genes
R5952 T19087 T19085 acl overlapping,QTL
R5953 T19590 T19588 pobj genes,of
R5954 T19591 T19590 nummod nine,genes
R5955 T19088 T19087 dobj HG11,overlapping
R5956 T19592 T19586 punct (,Four
R5957 T19593 T19586 appos Ubr1,Four
R5958 T19594 T19593 punct ", ",Ubr1
R5959 T19089 T19082 aux have,identified
R5960 T19595 T19593 conj Ptpns1,Ubr1
R5961 T19596 T19595 punct ", ",Ptpns1
R5962 T19090 T19082 auxpass been,identified
R5963 T19597 T19595 conj Ubce7ip5,Ptpns1
R5964 T19598 T19597 cc and,Ubce7ip5
R5965 T19091 T19082 prep in,identified
R5966 T19599 T19597 conj Mmp9,Ubce7ip5
R5967 T19600 T19593 punct ;,Ubr1
R5968 T19092 T19093 det a,number
R5969 T19601 T19602 dep all,are
R5970 T19602 T19593 relcl are,Ubr1
R5971 T19603 T19601 prep of,all
R5972 T19093 T19091 pobj number,in
R5973 T19604 T19603 pobj which,of
R5974 T19605 T19602 prep on,are
R5975 T19606 T19605 pobj MMU2,on
R5976 T19094 T19093 prep of,number
R5977 T19607 T19587 punct ),are
R5978 T19608 T19587 prep of,are
R5979 T19609 T19610 amod particular,interest
R5980 T19095 T19094 pobj crosses,of
R5981 T19610 T19608 pobj interest,of
R5982 T19611 T19587 punct .,are
R5983 T19096 T19082 advcl using,identified
R5984 T19613 T19614 nsubjpass It,suggested
R5985 T19097 T19098 amod different,strains
R5986 T19615 T19614 aux has,suggested
R5987 T19616 T19614 auxpass been,suggested
R5988 T19098 T19096 dobj strains,using
R5989 T19617 T19618 det the,Socs2
R5990 T19618 T19619 nsubj Socs2,rely
R5991 T19619 T19614 advcl rely,suggested
R5992 T19099 T19098 compound mouse,strains
R5993 T19620 T19619 aux may,rely
R5994 T19621 T19619 prep on,rely
R5995 T19100 T19101 punct [,37
R5996 T19622 T19623 npadvmod ubiquitination,dependent
R5997 T19623 T19624 amod dependent,degradation
R5998 T19624 T19621 pobj degradation,on
R5999 T19625 T19624 amod proteasomal,degradation
R6000 T19101 T19082 parataxis 37,identified
R6001 T19102 T19103 punct -,41
R6002 T19626 T19627 aux to,inhibit
R6003 T19627 T19619 advcl inhibit,rely
R6004 T19628 T19629 compound Gh,signaling
R6005 T19629 T19627 dobj signaling,inhibit
R6006 T19630 T19631 punct [,23
R6007 T19103 T19101 prep 41,37
R6008 T19631 T19614 parataxis 23,suggested
R6009 T19632 T19631 punct ],23
R6010 T19633 T19614 punct .,suggested
R6011 T19104 T19101 punct ],37
R6012 T19635 T19636 nsubjpass Ubr1,involved
R6013 T19105 T19082 punct .,identified
R6014 T19637 T19635 cc and,Ubr1
R6015 T19638 T19635 conj Ubce7ip5,Ubr1
R6016 T19107 T19108 advcl Given,is
R6017 T19639 T19636 auxpass are,involved
R6018 T19640 T19636 advmod both,involved
R6019 T19641 T19636 prep in,involved
R6020 T19642 T19643 compound protein,ubiquitination
R6021 T19109 T19110 det the,nature
R6022 T19643 T19641 pobj ubiquitination,in
R6023 T19644 T19636 cc and,involved
R6024 T19645 T19646 compound Ubr1,knockout
R6025 T19646 T19647 compound knockout,mice
R6026 T19110 T19107 dobj nature,Given
R6027 T19647 T19648 nsubj mice,show
R6028 T19648 T19636 conj show,involved
R6029 T19111 T19112 advmod well,documented
R6030 T19649 T19650 det an,decrease
R6031 T19650 T19648 dobj decrease,show
R6032 T19651 T19652 nummod 20,%
R6033 T19112 T19110 amod documented,nature
R6034 T19652 T19650 compound %,decrease
R6035 T19653 T19650 prep in,decrease
R6036 T19654 T19655 compound body,weight
R6037 T19113 T19114 advmod sexually,dimorphic
R6038 T19655 T19653 pobj weight,in
R6039 T19656 T19657 advmod partly,due
R6040 T19114 T19110 amod dimorphic,nature
R6041 T19657 T19648 prep due,show
R6042 T19658 T19657 pcomp to,due
R6043 T19659 T19660 det a,reduction
R6044 T19115 T19110 prep of,nature
R6045 T19660 T19657 pobj reduction,due
R6046 T19661 T19660 prep in,reduction
R6047 T19116 T19117 compound Gh,secretion
R6048 T19662 T19663 compound adipose,tissue
R6049 T19663 T19661 pobj tissue,in
R6050 T19664 T19665 punct [,51
R6051 T19665 T19648 parataxis 51,show
R6052 T19666 T19665 nummod 50,51
R6053 T19667 T19665 punct ",",51
R6054 T19117 T19115 pobj secretion,of
R6055 T19668 T19665 punct ],51
R6056 T19669 T19648 punct .,show
R6057 T19118 T19117 cc and,secretion
R6058 T19671 T19672 compound Ptpns1,mice
R6059 T19672 T19674 nsubj mice,displayed
R6060 T19119 T19120 npadvmod Gh,induced
R6061 T19673 T19672 compound knockout,mice
R6062 T19120 T19121 amod induced,expression
R6063 T19675 T19676 det a,reduction
R6064 T19676 T19674 dobj reduction,displayed
R6065 T19677 T19678 nummod 10,%
R6066 T19121 T19117 conj expression,secretion
R6067 T19678 T19676 compound %,reduction
R6068 T19679 T19676 prep in,reduction
R6069 T19680 T19681 compound body,weight
R6070 T19122 T19121 compound gene,expression
R6071 T19681 T19679 pobj weight,in
R6072 T19682 T19683 punct [,52
R6073 T19123 T19124 punct [,43
R6074 T19683 T19674 parataxis 52,displayed
R6075 T19684 T19683 punct ],52
R6076 T19685 T19674 cc and,displayed
R6077 T19124 T19107 parataxis 43,Given
R6078 T19686 T19687 compound Mmp9,mice
R6079 T19687 T19689 nsubj mice,show
R6080 T19125 T19124 nummod 42,43
R6081 T19688 T19687 compound knockout,mice
R6082 T19689 T19674 conj show,displayed
R6083 T19126 T19124 punct ",",43
R6084 T19127 T19124 punct ],43
R6085 T19690 T19691 det a,reduction
R6086 T19691 T19689 dobj reduction,show
R6087 T19128 T19108 punct ", ",is
R6088 T19692 T19691 prep in,reduction
R6089 T19693 T19692 pobj size,in
R6090 T19694 T19691 cc and,reduction
R6091 T19129 T19108 nsubj it,is
R6092 T19695 T19696 advmod drastically,reduced
R6093 T19696 T19697 amod reduced,length
R6094 T19130 T19108 acomp probable,is
R6095 T19697 T19691 conj length,reduction
R6096 T19698 T19697 compound bone,length
R6097 T19699 T19700 punct [,53
R6098 T19131 T19132 mark that,reside
R6099 T19700 T19689 parataxis 53,show
R6100 T19701 T19700 punct ],53
R6101 T19702 T19689 punct .,show
R6102 T19132 T19108 ccomp reside,is
R6103 T19704 T19705 nsubj All,are
R6104 T19706 T19704 prep of,All
R6105 T19133 T19134 det the,mutation
R6106 T19707 T19708 det these,genes
R6107 T19708 T19706 pobj genes,of
R6108 T19134 T19132 nsubj mutation,reside
R6109 T19709 T19710 amod excellent,genes
R6110 T19135 T19134 amod underlying,mutation
R6111 T19136 T19134 prep in,mutation
R6112 T19710 T19705 attr genes,are
R6113 T19137 T19138 det the,HG11
R6114 T19711 T19710 amod functional,genes
R6115 T19712 T19711 cc and,functional
R6116 T19138 T19136 pobj HG11,in
R6117 T19713 T19711 conj positional,functional
R6118 T19714 T19715 compound hg,modifier
R6119 T19139 T19138 amod congenic,HG11
R6120 T19715 T19710 compound modifier,genes
R6121 T19716 T19710 compound candidate,genes
R6122 T19717 T19705 cc and,are
R6123 T19140 T19132 aux may,reside
R6124 T19718 T19719 det this,information
R6125 T19719 T19720 nsubjpass information,incorporated
R6126 T19141 T19132 prep in,reside
R6127 T19720 T19705 conj incorporated,are
R6128 T19721 T19720 aux can,incorporated
R6129 T19722 T19720 auxpass be,incorporated
R6130 T19723 T19720 prep into,incorporated
R6131 T19724 T19725 amod future,studies
R6132 T19142 T19143 det a,gene
R6133 T19725 T19723 pobj studies,into
R6134 T19726 T19727 amod fine,mapping
R6135 T19727 T19725 compound mapping,studies
R6136 T19728 T19720 punct .,incorporated
R6137 T19143 T19141 pobj gene,in
R6138 T19144 T19143 acl enhancing,gene
R6139 T19145 T19146 npadvmod Gh,induced
R6140 T19146 T19147 amod induced,effects
R6141 T19147 T19144 dobj effects,enhancing
R6142 T19148 T19149 npadvmod sex,specific
R6143 T19149 T19147 amod specific,effects
R6144 T19150 T19149 punct -,specific
R6145 T19151 T19108 punct .,is
R6146 T19153 T19154 det The,gene
R6147 T19154 T19157 nsubj gene,are
R6148 T19155 T19154 amod structural,gene
R6149 T19156 T19154 compound Gh,gene
R6150 T19158 T19154 appos itself,gene
R6151 T19159 T19154 cc and,gene
R6152 T19160 T19154 conj Stat5b,gene
R6153 T19161 T19162 amod excellent,candidates
R6154 T19162 T19157 attr candidates,are
R6155 T19163 T19157 punct .,are
R6156 T19165 T19166 det The,role
R6157 T19166 T19168 nsubj role,include
R6158 T19167 T19166 amod potential,role
R6159 T19169 T19166 prep of,role
R6160 T19170 T19169 pobj Gh,of
R6161 T19171 T19168 aux would,include
R6162 T19172 T19168 dobj polymorphism,include
R6163 T19173 T19174 dep that,alters
R6164 T19174 T19172 advcl alters,polymorphism
R6165 T19175 T19176 compound protein,function
R6166 T19176 T19174 dobj function,alters
R6167 T19177 T19174 prep in,alters
R6168 T19178 T19179 det the,absence
R6169 T19179 T19177 pobj absence,in
R6170 T19180 T19179 prep of,absence
R6171 T19181 T19180 pobj Socs2,of
R6172 T19182 T19174 cc or,alters
R6173 T19183 T19184 dep that,causes
R6174 T19184 T19174 conj causes,alters
R6175 T19185 T19186 amod transcriptional,deregulation
R6176 T19186 T19184 dobj deregulation,causes
R6177 T19187 T19186 prep of,deregulation
R6178 T19188 T19187 pobj Gh,of
R6179 T19189 T19168 punct .,include
R6180 T19191 T19192 advmod Additionally,explain
R6181 T19193 T19192 punct ", ",explain
R6182 T19194 T19195 amod functional,variation
R6183 T19195 T19192 nsubj variation,explain
R6184 T19196 T19195 prep in,variation
R6185 T19197 T19196 pobj Stat5b,in
R6186 T19198 T19192 aux may,explain
R6187 T19199 T19200 det the,phenotypes
R6188 T19200 T19192 dobj phenotypes,explain