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PMC:1482699 / 1604-46922 JSONTXT 4 Projects

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Id Subject Object Predicate Lexical cue
T2716 11-14 DT denotes The
T2717 15-18 NN denotes use
T2719 19-21 IN denotes of
T2720 22-27 NN denotes mouse
T2721 28-34 NNS denotes models
T2722 35-38 VBZ denotes has
T2718 39-47 VBN denotes provided
T2723 48-56 JJ denotes valuable
T2724 57-64 NN denotes insight
T2725 65-69 IN denotes into
T2726 70-73 DT denotes the
T2727 74-82 NN denotes etiology
T2728 83-85 IN denotes of
T2729 86-95 JJ denotes monogenic
T2730 96-105 NNS denotes syndromes
T2731 106-112 VBN denotes caused
T2732 113-115 IN denotes by
T2733 116-122 JJ denotes single
T2735 123-127 NN denotes gene
T2734 128-137 NNS denotes mutations
T2736 137-138 . denotes .
T2737 138-252 sentence denotes However, such models do not mimic the genetic complexity of disease traits commonly seen in the human population.
T2738 139-146 RB denotes However
T2740 146-148 , denotes ,
T2741 148-152 JJ denotes such
T2742 153-159 NNS denotes models
T2743 160-162 VBP denotes do
T2744 163-166 RB denotes not
T2739 167-172 VB denotes mimic
T2745 173-176 DT denotes the
T2747 177-184 JJ denotes genetic
T2746 185-195 NN denotes complexity
T2748 196-198 IN denotes of
T2749 199-206 NN denotes disease
T2750 207-213 NNS denotes traits
T2751 214-222 RB denotes commonly
T2752 223-227 VBN denotes seen
T2753 228-230 IN denotes in
T2754 231-234 DT denotes the
T2756 235-240 JJ denotes human
T2755 241-251 NN denotes population
T2757 251-252 . denotes .
T2758 252-487 sentence denotes Complex traits, such as polygenic growth and obesity are influenced by the small to moderate direct effects of quantitative trait loci (QTL), epistasis between QTL alleles, environmental perturbations and QTL-environment interactions.
T2759 253-260 NN denotes Complex
T2760 261-267 NNS denotes traits
T2762 267-269 , denotes ,
T2763 269-273 JJ denotes such
T2764 274-276 IN denotes as
T2765 277-286 JJ denotes polygenic
T2766 287-293 NN denotes growth
T2767 294-297 CC denotes and
T2768 298-305 NN denotes obesity
T2769 306-309 VBP denotes are
T2761 310-320 VBN denotes influenced
T2770 321-323 IN denotes by
T2771 324-327 DT denotes the
T2773 328-333 JJ denotes small
T2774 334-336 IN denotes to
T2775 337-345 JJ denotes moderate
T2776 346-352 JJ denotes direct
T2772 353-360 NNS denotes effects
T2777 361-363 IN denotes of
T2778 364-376 JJ denotes quantitative
T2780 377-382 NN denotes trait
T2779 383-387 NNS denotes loci
T2781 388-389 -LRB- denotes (
T2782 389-392 NN denotes QTL
T2783 392-393 -RRB- denotes )
T2784 393-395 , denotes ,
T2785 395-404 NN denotes epistasis
T2786 405-412 IN denotes between
T2787 413-416 NN denotes QTL
T2788 417-424 NNS denotes alleles
T2789 424-426 , denotes ,
T2790 426-439 JJ denotes environmental
T2791 440-453 NNS denotes perturbations
T2792 454-457 CC denotes and
T2793 458-461 NN denotes QTL
T2795 461-462 HYPH denotes -
T2794 462-473 NN denotes environment
T2796 474-486 NNS denotes interactions
T2797 486-487 . denotes .
T2798 487-670 sentence denotes To date numerous mouse growth and obesity QTL have been localized [1,2], however, little progress has been made in determining the specific nature of the underlying genetic variants.
T2799 488-490 IN denotes To
T2801 491-495 NN denotes date
T2802 496-504 JJ denotes numerous
T2804 505-510 NN denotes mouse
T2805 511-517 NN denotes growth
T2806 518-521 CC denotes and
T2807 522-529 NN denotes obesity
T2803 530-533 NN denotes QTL
T2808 534-538 VBP denotes have
T2809 539-543 VBN denotes been
T2800 544-553 VBN denotes localized
T2811 554-555 -LRB- denotes [
T2813 555-556 CD denotes 1
T2814 556-557 , denotes ,
T2812 557-558 CD denotes 2
T2815 558-559 -RRB- denotes ]
T2816 559-561 , denotes ,
T2817 561-568 RB denotes however
T2818 568-570 , denotes ,
T2819 570-576 JJ denotes little
T2820 577-585 NN denotes progress
T2821 586-589 VBZ denotes has
T2822 590-594 VBN denotes been
T2810 595-599 VBN denotes made
T2823 600-602 IN denotes in
T2824 603-614 VBG denotes determining
T2825 615-618 DT denotes the
T2827 619-627 JJ denotes specific
T2826 628-634 NN denotes nature
T2828 635-637 IN denotes of
T2829 638-641 DT denotes the
T2831 642-652 VBG denotes underlying
T2832 653-660 JJ denotes genetic
T2830 661-669 NNS denotes variants
T2833 669-670 . denotes .
T2834 670-819 sentence denotes One resource used to fine map QTL are congenic strains which are designed to convert a complex polygenic trait into one that is mono- or oligogenic.
T2835 671-674 CD denotes One
T2836 675-683 NN denotes resource
T2838 684-688 VBN denotes used
T2839 689-691 TO denotes to
T2841 692-696 RB denotes fine
T2840 697-700 VB denotes map
T2842 701-704 NN denotes QTL
T2837 705-708 VBP denotes are
T2843 709-717 JJ denotes congenic
T2844 718-725 NNS denotes strains
T2845 726-731 WDT denotes which
T2847 732-735 VBP denotes are
T2846 736-744 VBN denotes designed
T2848 745-747 TO denotes to
T2849 748-755 VB denotes convert
T2850 756-757 DT denotes a
T2852 758-765 JJ denotes complex
T2853 766-775 JJ denotes polygenic
T2851 776-781 NN denotes trait
T2854 782-786 IN denotes into
T2855 787-790 CD denotes one
T2856 791-795 WDT denotes that
T2857 796-798 VBZ denotes is
T2858 799-803 AFX denotes mono
T2860 803-804 HYPH denotes -
T2861 805-807 CC denotes or
T2859 808-818 JJ denotes oligogenic
T2862 818-819 . denotes .
T2863 819-1039 sentence denotes This is accomplished by eliminating segregating genetic variation outside the locus of interest and reducing the environmental variation influencing a trait by characterizing large numbers of genetically identical mice.
T2864 820-824 DT denotes This
T2866 825-827 VBZ denotes is
T2865 828-840 VBN denotes accomplished
T2867 841-843 IN denotes by
T2868 844-855 VBG denotes eliminating
T2869 856-867 VBG denotes segregating
T2870 868-875 JJ denotes genetic
T2871 876-885 NN denotes variation
T2872 886-893 IN denotes outside
T2873 894-897 DT denotes the
T2874 898-903 NN denotes locus
T2875 904-906 IN denotes of
T2876 907-915 NN denotes interest
T2877 916-919 CC denotes and
T2878 920-928 VBG denotes reducing
T2879 929-932 DT denotes the
T2881 933-946 JJ denotes environmental
T2880 947-956 NN denotes variation
T2882 957-968 VBG denotes influencing
T2883 969-970 DT denotes a
T2884 971-976 NN denotes trait
T2885 977-979 IN denotes by
T2886 980-994 VBG denotes characterizing
T2887 995-1000 JJ denotes large
T2888 1001-1008 NNS denotes numbers
T2889 1009-1011 IN denotes of
T2890 1012-1023 RB denotes genetically
T2891 1024-1033 JJ denotes identical
T2892 1034-1038 NNS denotes mice
T2893 1038-1039 . denotes .
T2894 1039-1168 sentence denotes The Complex Trait Consortium (CTC) considers congenic analysis an excellent method to confirm and subsequently fine map QTL [3].
T2895 1040-1043 DT denotes The
T2897 1044-1051 NNP denotes Complex
T2898 1052-1057 NNP denotes Trait
T2896 1058-1068 NNP denotes Consortium
T2900 1069-1070 -LRB- denotes (
T2901 1070-1073 NNP denotes CTC
T2902 1073-1074 -RRB- denotes )
T2899 1075-1084 VBZ denotes considers
T2903 1085-1093 JJ denotes congenic
T2904 1094-1102 NN denotes analysis
T2906 1103-1105 DT denotes an
T2907 1106-1115 JJ denotes excellent
T2905 1116-1122 NN denotes method
T2908 1123-1125 TO denotes to
T2909 1126-1133 VB denotes confirm
T2910 1134-1137 CC denotes and
T2911 1138-1150 RB denotes subsequently
T2913 1151-1155 RB denotes fine
T2912 1156-1159 VB denotes map
T2914 1160-1163 NN denotes QTL
T2915 1164-1165 -LRB- denotes [
T2916 1165-1166 CD denotes 3
T2917 1166-1167 -RRB- denotes ]
T2918 1167-1168 . denotes .
T2919 1168-1385 sentence denotes Traditionally, congenic strains are developed by introgressing QTL alleles from a donor strain, whose boundaries are defined by genetic markers, on the genetic background of a recipient strain via 10 backcrosses [4].
T2920 1169-1182 RB denotes Traditionally
T2922 1182-1184 , denotes ,
T2923 1184-1192 JJ denotes congenic
T2924 1193-1200 NNS denotes strains
T2925 1201-1204 VBP denotes are
T2921 1205-1214 VBN denotes developed
T2926 1215-1217 IN denotes by
T2927 1218-1231 VBG denotes introgressing
T2928 1232-1235 NN denotes QTL
T2929 1236-1243 NNS denotes alleles
T2930 1244-1248 IN denotes from
T2931 1249-1250 DT denotes a
T2933 1251-1256 NN denotes donor
T2932 1257-1263 NN denotes strain
T2934 1263-1265 , denotes ,
T2935 1265-1270 WP$ denotes whose
T2936 1271-1281 NNS denotes boundaries
T2938 1282-1285 VBP denotes are
T2937 1286-1293 VBN denotes defined
T2939 1294-1296 IN denotes by
T2940 1297-1304 JJ denotes genetic
T2941 1305-1312 NNS denotes markers
T2942 1312-1314 , denotes ,
T2943 1314-1316 IN denotes on
T2944 1317-1320 DT denotes the
T2946 1321-1328 JJ denotes genetic
T2945 1329-1339 NN denotes background
T2947 1340-1342 IN denotes of
T2948 1343-1344 DT denotes a
T2950 1345-1354 NN denotes recipient
T2949 1355-1361 NN denotes strain
T2951 1362-1365 IN denotes via
T2952 1366-1368 CD denotes 10
T2953 1369-1380 NNS denotes backcrosses
T2954 1381-1382 -LRB- denotes [
T2955 1382-1383 CD denotes 4
T2956 1383-1384 -RRB- denotes ]
T2957 1384-1385 . denotes .
T2958 1385-1507 sentence denotes While technically straightforward this is a time consuming endeavor taking over three years to construct a single strain.
T2959 1386-1391 IN denotes While
T2961 1392-1403 RB denotes technically
T2960 1404-1419 JJ denotes straightforward
T2963 1420-1424 NN denotes this
T2962 1425-1427 VBZ denotes is
T2964 1428-1429 DT denotes a
T2966 1430-1434 NN denotes time
T2967 1435-1444 VBG denotes consuming
T2965 1445-1453 NN denotes endeavor
T2968 1454-1460 VBG denotes taking
T2969 1461-1465 IN denotes over
T2970 1466-1471 CD denotes three
T2971 1472-1477 NNS denotes years
T2972 1478-1480 TO denotes to
T2973 1481-1490 VB denotes construct
T2974 1491-1492 DT denotes a
T2976 1493-1499 JJ denotes single
T2975 1500-1506 NN denotes strain
T2977 1506-1507 . denotes .
T2978 1507-1650 sentence denotes The speed congenic approach is an alternative to this lengthy process and can reduce the number of required backcrosses from 10 to five [5,6].
T2979 1508-1511 DT denotes The
T2981 1512-1517 NN denotes speed
T2982 1518-1526 JJ denotes congenic
T2980 1527-1535 NN denotes approach
T2983 1536-1538 VBZ denotes is
T2984 1539-1541 DT denotes an
T2985 1542-1553 NN denotes alternative
T2986 1554-1556 IN denotes to
T2987 1557-1561 DT denotes this
T2989 1562-1569 JJ denotes lengthy
T2988 1570-1577 NN denotes process
T2990 1578-1581 CC denotes and
T2991 1582-1585 MD denotes can
T2992 1586-1592 VB denotes reduce
T2993 1593-1596 DT denotes the
T2994 1597-1603 NN denotes number
T2995 1604-1606 IN denotes of
T2996 1607-1615 VBN denotes required
T2997 1616-1627 NNS denotes backcrosses
T2998 1628-1632 IN denotes from
T2999 1633-1635 CD denotes 10
T3000 1636-1638 IN denotes to
T3001 1639-1643 CD denotes five
T3002 1644-1645 -LRB- denotes [
T3004 1645-1646 CD denotes 5
T3005 1646-1647 , denotes ,
T3003 1647-1648 CD denotes 6
T3006 1648-1649 -RRB- denotes ]
T3007 1649-1650 . denotes .
T3008 1650-1798 sentence denotes This strategy uses marker-assisted selection to identify male mice inheriting fewer donor alleles, than expected on average, during each backcross.
T3009 1651-1655 DT denotes This
T3010 1656-1664 NN denotes strategy
T3011 1665-1669 VBZ denotes uses
T3012 1670-1676 NN denotes marker
T3014 1676-1677 HYPH denotes -
T3013 1677-1685 VBN denotes assisted
T3015 1686-1695 NN denotes selection
T3016 1696-1698 TO denotes to
T3017 1699-1707 VB denotes identify
T3018 1708-1712 JJ denotes male
T3019 1713-1717 NNS denotes mice
T3020 1718-1728 VBG denotes inheriting
T3021 1729-1734 JJR denotes fewer
T3023 1735-1740 NN denotes donor
T3022 1741-1748 NNS denotes alleles
T3024 1748-1750 , denotes ,
T3025 1750-1754 IN denotes than
T3026 1755-1763 VBN denotes expected
T3027 1764-1766 IN denotes on
T3028 1767-1774 JJ denotes average
T3029 1774-1776 , denotes ,
T3030 1776-1782 IN denotes during
T3031 1783-1787 DT denotes each
T3032 1788-1797 NN denotes backcross
T3033 1797-1798 . denotes .
T3034 1798-1965 sentence denotes Numerous traditionally developed and speed congenics have been used to successfully isolate mouse QTL for a wide array of traits, including growth and obesity [7-13].
T3035 1799-1807 JJ denotes Numerous
T3037 1808-1821 RB denotes traditionally
T3038 1822-1831 VBN denotes developed
T3039 1832-1835 CC denotes and
T3040 1836-1841 NN denotes speed
T3036 1842-1851 NNS denotes congenics
T3042 1852-1856 VBP denotes have
T3043 1857-1861 VBN denotes been
T3041 1862-1866 VBN denotes used
T3044 1867-1869 TO denotes to
T3046 1870-1882 RB denotes successfully
T3045 1883-1890 VB denotes isolate
T3047 1891-1896 NN denotes mouse
T3048 1897-1900 NN denotes QTL
T3049 1901-1904 IN denotes for
T3050 1905-1906 DT denotes a
T3052 1907-1911 JJ denotes wide
T3051 1912-1917 NN denotes array
T3053 1918-1920 IN denotes of
T3054 1921-1927 NNS denotes traits
T3055 1927-1929 , denotes ,
T3056 1929-1938 VBG denotes including
T3057 1939-1945 NN denotes growth
T3058 1946-1949 CC denotes and
T3059 1950-1957 NN denotes obesity
T3060 1958-1959 -LRB- denotes [
T3061 1959-1960 CD denotes 7
T3062 1960-1961 SYM denotes -
T3063 1961-1963 CD denotes 13
T3064 1963-1964 -RRB- denotes ]
T3065 1964-1965 . denotes .
T3066 1965-2169 sentence denotes The C57Bl/6J-hg/hg (HG) mouse is a model of systemic overgrowth resulting from a spontaneous deletion on MMU10, which eliminates expression of the Socs2 (suppressor of cytokine signaling 2) gene [14-16].
T3067 1966-1969 DT denotes The
T3069 1970-1975 NN denotes C57Bl
T3071 1975-1976 HYPH denotes /
T3072 1976-1978 NN denotes 6J
T3073 1978-1979 HYPH denotes -
T3074 1979-1981 NN denotes hg
T3075 1981-1982 HYPH denotes /
T3070 1982-1984 NN denotes hg
T3076 1985-1986 -LRB- denotes (
T3077 1986-1988 NN denotes HG
T3078 1988-1989 -RRB- denotes )
T3068 1990-1995 NN denotes mouse
T3079 1996-1998 VBZ denotes is
T3080 1999-2000 DT denotes a
T3081 2001-2006 NN denotes model
T3082 2007-2009 IN denotes of
T3083 2010-2018 JJ denotes systemic
T3084 2019-2029 NN denotes overgrowth
T3085 2030-2039 VBG denotes resulting
T3086 2040-2044 IN denotes from
T3087 2045-2046 DT denotes a
T3089 2047-2058 JJ denotes spontaneous
T3088 2059-2067 NN denotes deletion
T3090 2068-2070 IN denotes on
T3091 2071-2076 NN denotes MMU10
T3092 2076-2078 , denotes ,
T3093 2078-2083 WDT denotes which
T3094 2084-2094 VBZ denotes eliminates
T3095 2095-2105 NN denotes expression
T3096 2106-2108 IN denotes of
T3097 2109-2112 DT denotes the
T3099 2113-2118 NN denotes Socs2
T3100 2119-2120 -LRB- denotes (
T3101 2120-2130 NN denotes suppressor
T3102 2131-2133 IN denotes of
T3103 2134-2142 NN denotes cytokine
T3104 2143-2152 NN denotes signaling
T3105 2153-2154 CD denotes 2
T3106 2154-2155 -RRB- denotes )
T3098 2156-2160 NN denotes gene
T3107 2161-2162 -LRB- denotes [
T3108 2162-2164 CD denotes 14
T3109 2164-2165 SYM denotes -
T3110 2165-2167 CD denotes 16
T3111 2167-2168 -RRB- denotes ]
T3112 2168-2169 . denotes .
T3113 2169-2357 sentence denotes The role of Socs2 in the HG phenotype was confirmed by an independently engineered Socs2-/- knockout mouse which shared a number of phenotypes in common with HG, including gigantism [17].
T3114 2170-2173 DT denotes The
T3115 2174-2178 NN denotes role
T3117 2179-2181 IN denotes of
T3118 2182-2187 NN denotes Socs2
T3119 2188-2190 IN denotes in
T3120 2191-2194 DT denotes the
T3122 2195-2197 NN denotes HG
T3121 2198-2207 NN denotes phenotype
T3123 2208-2211 VBD denotes was
T3116 2212-2221 VBN denotes confirmed
T3124 2222-2224 IN denotes by
T3125 2225-2227 DT denotes an
T3127 2228-2241 RB denotes independently
T3128 2242-2252 VBN denotes engineered
T3129 2253-2258 NN denotes Socs2
T3131 2258-2259 SYM denotes -
T3132 2259-2260 HYPH denotes /
T3133 2260-2261 SYM denotes -
T3130 2262-2270 NN denotes knockout
T3126 2271-2276 NN denotes mouse
T3134 2277-2282 WDT denotes which
T3135 2283-2289 VBD denotes shared
T3136 2290-2291 DT denotes a
T3137 2292-2298 NN denotes number
T3138 2299-2301 IN denotes of
T3139 2302-2312 NNS denotes phenotypes
T3140 2313-2315 IN denotes in
T3141 2316-2322 NN denotes common
T3142 2323-2327 IN denotes with
T3143 2328-2330 NN denotes HG
T3144 2330-2332 , denotes ,
T3145 2332-2341 VBG denotes including
T3146 2342-2351 NN denotes gigantism
T3147 2352-2353 -LRB- denotes [
T3148 2353-2355 CD denotes 17
T3149 2355-2356 -RRB- denotes ]
T3150 2356-2357 . denotes .
T3151 2357-2451 sentence denotes QTL which alter the phenotypic effects of another locus are referred to as modifier QTL [18].
T3152 2358-2361 NN denotes QTL
T3154 2362-2367 WDT denotes which
T3155 2368-2373 VBP denotes alter
T3156 2374-2377 DT denotes the
T3158 2378-2388 JJ denotes phenotypic
T3157 2389-2396 NNS denotes effects
T3159 2397-2399 IN denotes of
T3160 2400-2407 DT denotes another
T3161 2408-2413 NN denotes locus
T3162 2414-2417 VBP denotes are
T3153 2418-2426 VBN denotes referred
T3163 2427-2429 IN denotes to
T3164 2430-2432 IN denotes as
T3165 2433-2441 NN denotes modifier
T3166 2442-2445 NN denotes QTL
T3167 2446-2447 -LRB- denotes [
T3168 2447-2449 CD denotes 18
T3169 2449-2450 -RRB- denotes ]
T3170 2450-2451 . denotes .
T3171 2451-2678 sentence denotes Modifier QTL have been mapped for numerous traits and in these studies the modified locus is typically a known gene containing a spontaneously arisen or engineered mutation with major phenotypic effects, such as hg [11,19-21].
T3172 2452-2460 NN denotes Modifier
T3173 2461-2464 NN denotes QTL
T3175 2465-2469 VBP denotes have
T3176 2470-2474 VBN denotes been
T3174 2475-2481 VBN denotes mapped
T3177 2482-2485 IN denotes for
T3178 2486-2494 JJ denotes numerous
T3179 2495-2501 NNS denotes traits
T3180 2502-2505 CC denotes and
T3181 2506-2508 IN denotes in
T3183 2509-2514 DT denotes these
T3184 2515-2522 NNS denotes studies
T3185 2523-2526 DT denotes the
T3187 2527-2535 VBN denotes modified
T3186 2536-2541 NN denotes locus
T3182 2542-2544 VBZ denotes is
T3188 2545-2554 RB denotes typically
T3189 2555-2556 DT denotes a
T3191 2557-2562 VBN denotes known
T3190 2563-2567 NN denotes gene
T3192 2568-2578 VBG denotes containing
T3193 2579-2580 DT denotes a
T3195 2581-2594 RB denotes spontaneously
T3196 2595-2601 VBN denotes arisen
T3197 2602-2604 CC denotes or
T3198 2605-2615 VBN denotes engineered
T3194 2616-2624 NN denotes mutation
T3199 2625-2629 IN denotes with
T3200 2630-2635 JJ denotes major
T3202 2636-2646 JJ denotes phenotypic
T3201 2647-2654 NNS denotes effects
T3203 2654-2656 , denotes ,
T3204 2656-2660 JJ denotes such
T3205 2661-2663 IN denotes as
T3206 2664-2666 NN denotes hg
T3207 2667-2668 -LRB- denotes [
T3208 2668-2670 CD denotes 11
T3209 2670-2671 , denotes ,
T3210 2671-2673 CD denotes 19
T3211 2673-2674 SYM denotes -
T3212 2674-2676 CD denotes 21
T3213 2676-2677 -RRB- denotes ]
T3214 2677-2678 . denotes .
T3215 2678-2832 sentence denotes Epistasis forms the basis of these interactions, implying that the known gene and its modifiers are members of the same biochemical or metabolic pathway.
T3216 2679-2688 NN denotes Epistasis
T3217 2689-2694 VBZ denotes forms
T3218 2695-2698 DT denotes the
T3219 2699-2704 NN denotes basis
T3220 2705-2707 IN denotes of
T3221 2708-2713 DT denotes these
T3222 2714-2726 NNS denotes interactions
T3223 2726-2728 , denotes ,
T3224 2728-2736 VBG denotes implying
T3225 2737-2741 IN denotes that
T3227 2742-2745 DT denotes the
T3229 2746-2751 VBN denotes known
T3228 2752-2756 NN denotes gene
T3230 2757-2760 CC denotes and
T3231 2761-2764 PRP$ denotes its
T3232 2765-2774 NNS denotes modifiers
T3226 2775-2778 VBP denotes are
T3233 2779-2786 NNS denotes members
T3234 2787-2789 IN denotes of
T3235 2790-2793 DT denotes the
T3237 2794-2798 JJ denotes same
T3238 2799-2810 JJ denotes biochemical
T3239 2811-2813 CC denotes or
T3240 2814-2823 JJ denotes metabolic
T3236 2824-2831 NN denotes pathway
T3241 2831-2832 . denotes .
T3242 2832-2932 sentence denotes Different genetic backgrounds have been shown to modify the growth-enhancing effects of hg [15,22].
T3243 2833-2842 JJ denotes Different
T3245 2843-2850 JJ denotes genetic
T3244 2851-2862 NNS denotes backgrounds
T3247 2863-2867 VBP denotes have
T3248 2868-2872 VBN denotes been
T3246 2873-2878 VBN denotes shown
T3249 2879-2881 TO denotes to
T3250 2882-2888 VB denotes modify
T3251 2889-2892 DT denotes the
T3253 2893-2899 NN denotes growth
T3255 2899-2900 HYPH denotes -
T3254 2900-2909 VBG denotes enhancing
T3252 2910-2917 NNS denotes effects
T3256 2918-2920 IN denotes of
T3257 2921-2923 NN denotes hg
T3258 2924-2925 -LRB- denotes [
T3260 2925-2927 CD denotes 15
T3261 2927-2928 , denotes ,
T3259 2928-2930 CD denotes 22
T3262 2930-2931 -RRB- denotes ]
T3263 2931-2932 . denotes .
T3264 2932-3159 sentence denotes Since the primary function of Socs2 is to negatively regulate growth hormone (Gh) [23], it is likely these background effects are the result of polymorphism influencing interactions between members of the Gh signaling pathway.
T3265 2933-2938 IN denotes Since
T3267 2939-2942 DT denotes the
T3269 2943-2950 JJ denotes primary
T3268 2951-2959 NN denotes function
T3270 2960-2962 IN denotes of
T3271 2963-2968 NN denotes Socs2
T3266 2969-2971 VBZ denotes is
T3273 2972-2974 TO denotes to
T3275 2975-2985 RB denotes negatively
T3274 2986-2994 VB denotes regulate
T3276 2995-3001 NN denotes growth
T3277 3002-3009 NN denotes hormone
T3278 3010-3011 -LRB- denotes (
T3279 3011-3013 NN denotes Gh
T3280 3013-3014 -RRB- denotes )
T3281 3015-3016 -LRB- denotes [
T3282 3016-3018 CD denotes 23
T3283 3018-3019 -RRB- denotes ]
T3284 3019-3021 , denotes ,
T3285 3021-3023 PRP denotes it
T3272 3024-3026 VBZ denotes is
T3286 3027-3033 JJ denotes likely
T3287 3034-3039 DT denotes these
T3289 3040-3050 NN denotes background
T3288 3051-3058 NNS denotes effects
T3290 3059-3062 VBP denotes are
T3291 3063-3066 DT denotes the
T3292 3067-3073 NN denotes result
T3293 3074-3076 IN denotes of
T3294 3077-3089 NN denotes polymorphism
T3295 3090-3101 VBG denotes influencing
T3296 3102-3114 NNS denotes interactions
T3297 3115-3122 IN denotes between
T3298 3123-3130 NNS denotes members
T3299 3131-3133 IN denotes of
T3300 3134-3137 DT denotes the
T3302 3138-3140 NN denotes Gh
T3303 3141-3150 NN denotes signaling
T3301 3151-3158 NN denotes pathway
T3304 3158-3159 . denotes .
T3305 3159-3328 sentence denotes Thus, identification of hg modifiers has the potential to uncover novel members of metabolically important pathways or previously unknown convergences between pathways.
T3306 3160-3164 RB denotes Thus
T3308 3164-3166 , denotes ,
T3309 3166-3180 NN denotes identification
T3310 3181-3183 IN denotes of
T3311 3184-3186 NN denotes hg
T3312 3187-3196 NNS denotes modifiers
T3307 3197-3200 VBZ denotes has
T3313 3201-3204 DT denotes the
T3314 3205-3214 NN denotes potential
T3315 3215-3217 TO denotes to
T3316 3218-3225 VB denotes uncover
T3317 3226-3231 JJ denotes novel
T3318 3232-3239 NNS denotes members
T3319 3240-3242 IN denotes of
T3320 3243-3256 RB denotes metabolically
T3321 3257-3266 JJ denotes important
T3322 3267-3275 NNS denotes pathways
T3323 3276-3278 CC denotes or
T3324 3279-3289 RB denotes previously
T3325 3290-3297 JJ denotes unknown
T3326 3298-3310 NNS denotes convergences
T3327 3311-3318 IN denotes between
T3328 3319-3327 NNS denotes pathways
T3329 3327-3328 . denotes .
T3330 3328-3447 sentence denotes As an initial step, growth and carcass composition QTL were identified in a cross between CAST/EiJ (CAST) and HG [24].
T3331 3329-3331 IN denotes As
T3333 3332-3334 DT denotes an
T3335 3335-3342 JJ denotes initial
T3334 3343-3347 NN denotes step
T3336 3347-3349 , denotes ,
T3337 3349-3355 NN denotes growth
T3339 3356-3359 CC denotes and
T3340 3360-3367 NN denotes carcass
T3341 3368-3379 NN denotes composition
T3338 3380-3383 NN denotes QTL
T3342 3384-3388 VBD denotes were
T3332 3389-3399 VBN denotes identified
T3343 3400-3402 IN denotes in
T3344 3403-3404 DT denotes a
T3345 3405-3410 NN denotes cross
T3346 3411-3418 IN denotes between
T3347 3419-3423 NN denotes CAST
T3349 3423-3424 HYPH denotes /
T3348 3424-3427 NN denotes EiJ
T3350 3428-3429 -LRB- denotes (
T3351 3429-3433 NN denotes CAST
T3352 3433-3434 -RRB- denotes )
T3353 3435-3438 CC denotes and
T3354 3439-3441 NN denotes HG
T3355 3442-3443 -LRB- denotes [
T3356 3443-3445 CD denotes 24
T3357 3445-3446 -RRB- denotes ]
T3358 3446-3447 . denotes .
T3359 3447-3686 sentence denotes In the F2, mice homozygous for the hg deletion (hg/hg) and wild type (+/+) were assayed and hg modifier QTL were defined as those either absent in +/+ mice and segregating in hg/hg or loci with altered gene action dependent on background.
T3360 3448-3450 IN denotes In
T3362 3451-3454 DT denotes the
T3363 3455-3457 NN denotes F2
T3364 3457-3459 , denotes ,
T3365 3459-3463 NNS denotes mice
T3366 3464-3474 JJ denotes homozygous
T3367 3475-3478 IN denotes for
T3368 3479-3482 DT denotes the
T3370 3483-3485 NN denotes hg
T3369 3486-3494 NN denotes deletion
T3371 3495-3496 -LRB- denotes (
T3373 3496-3498 NN denotes hg
T3374 3498-3499 HYPH denotes /
T3372 3499-3501 NN denotes hg
T3375 3501-3502 -RRB- denotes )
T3376 3503-3506 CC denotes and
T3377 3507-3511 JJ denotes wild
T3378 3512-3516 NN denotes type
T3379 3517-3518 -LRB- denotes (
T3380 3518-3519 SYM denotes +
T3382 3519-3520 HYPH denotes /
T3381 3520-3521 SYM denotes +
T3383 3521-3522 -RRB- denotes )
T3384 3523-3527 VBD denotes were
T3361 3528-3535 VBN denotes assayed
T3385 3536-3539 CC denotes and
T3386 3540-3542 NN denotes hg
T3387 3543-3551 NN denotes modifier
T3388 3552-3555 NN denotes QTL
T3390 3556-3560 VBD denotes were
T3389 3561-3568 VBN denotes defined
T3391 3569-3571 IN denotes as
T3392 3572-3577 DT denotes those
T3393 3578-3584 CC denotes either
T3394 3585-3591 JJ denotes absent
T3395 3592-3594 IN denotes in
T3396 3595-3596 SYM denotes +
T3398 3596-3597 HYPH denotes /
T3397 3597-3598 SYM denotes +
T3399 3599-3603 NNS denotes mice
T3400 3604-3607 CC denotes and
T3401 3608-3619 VBG denotes segregating
T3402 3620-3622 IN denotes in
T3403 3623-3625 NN denotes hg
T3405 3625-3626 HYPH denotes /
T3404 3626-3628 NN denotes hg
T3406 3629-3631 CC denotes or
T3407 3632-3636 NNS denotes loci
T3408 3637-3641 IN denotes with
T3409 3642-3649 VBN denotes altered
T3411 3650-3654 NN denotes gene
T3410 3655-3661 NN denotes action
T3412 3662-3671 JJ denotes dependent
T3413 3672-3674 IN denotes on
T3414 3675-3685 NN denotes background
T3415 3685-3686 . denotes .
T3416 3686-4089 sentence denotes Four hg modifier QTL (Wg2 on MMU2, Carfhg2 on MMU9, Carp2 on MMU11 and Feml3 on MMU17) were identified, along with 12 additional QTL (Q1Ucd1 on MMU1 (which only reached a suggestive level of statistical significance), Wg1, Carp1, Cara1 and Feml1 on MMU2, Carfhg1 on MMU5, Wg3 on MMU8, Feml2 on MMU9, Wg4 and Cara2 on MMU11 and Carp3 and Cara3 on MMU17) whose expression was independent of the hg locus.
T3417 3687-3691 CD denotes Four
T3418 3692-3694 NN denotes hg
T3420 3695-3703 NN denotes modifier
T3419 3704-3707 NN denotes QTL
T3422 3708-3709 -LRB- denotes (
T3423 3709-3712 NN denotes Wg2
T3424 3713-3715 IN denotes on
T3425 3716-3720 NN denotes MMU2
T3426 3720-3722 , denotes ,
T3427 3722-3729 NN denotes Carfhg2
T3428 3730-3732 IN denotes on
T3429 3733-3737 NN denotes MMU9
T3430 3737-3739 , denotes ,
T3431 3739-3744 NN denotes Carp2
T3432 3745-3747 IN denotes on
T3433 3748-3753 NN denotes MMU11
T3434 3754-3757 CC denotes and
T3435 3758-3763 NN denotes Feml3
T3436 3764-3766 IN denotes on
T3437 3767-3772 NN denotes MMU17
T3438 3772-3773 -RRB- denotes )
T3439 3774-3778 VBD denotes were
T3421 3779-3789 VBN denotes identified
T3440 3789-3791 , denotes ,
T3441 3791-3796 IN denotes along
T3442 3797-3801 IN denotes with
T3443 3802-3804 CD denotes 12
T3445 3805-3815 JJ denotes additional
T3444 3816-3819 NN denotes QTL
T3446 3820-3821 -LRB- denotes (
T3447 3821-3827 NN denotes Q1Ucd1
T3448 3828-3830 IN denotes on
T3449 3831-3835 NN denotes MMU1
T3450 3836-3837 -LRB- denotes (
T3451 3837-3842 WDT denotes which
T3453 3843-3847 RB denotes only
T3452 3848-3855 VBD denotes reached
T3454 3856-3857 DT denotes a
T3456 3858-3868 JJ denotes suggestive
T3455 3869-3874 NN denotes level
T3457 3875-3877 IN denotes of
T3458 3878-3889 JJ denotes statistical
T3459 3890-3902 NN denotes significance
T3460 3902-3903 -RRB- denotes )
T3461 3903-3905 , denotes ,
T3462 3905-3908 NN denotes Wg1
T3463 3908-3910 , denotes ,
T3464 3910-3915 NN denotes Carp1
T3465 3915-3917 , denotes ,
T3466 3917-3922 NN denotes Cara1
T3467 3923-3926 CC denotes and
T3468 3927-3932 NN denotes Feml1
T3469 3933-3935 IN denotes on
T3470 3936-3940 NN denotes MMU2
T3471 3940-3942 , denotes ,
T3472 3942-3949 NN denotes Carfhg1
T3473 3950-3952 IN denotes on
T3474 3953-3957 NN denotes MMU5
T3475 3957-3959 , denotes ,
T3476 3959-3962 NN denotes Wg3
T3477 3963-3965 IN denotes on
T3478 3966-3970 NN denotes MMU8
T3479 3970-3972 , denotes ,
T3480 3972-3977 NN denotes Feml2
T3481 3978-3980 IN denotes on
T3482 3981-3985 NN denotes MMU9
T3483 3985-3987 , denotes ,
T3484 3987-3990 NN denotes Wg4
T3485 3991-3994 CC denotes and
T3486 3995-4000 NN denotes Cara2
T3487 4001-4003 IN denotes on
T3488 4004-4009 NN denotes MMU11
T3489 4010-4013 CC denotes and
T3490 4014-4019 NN denotes Carp3
T3491 4020-4023 CC denotes and
T3492 4024-4029 NN denotes Cara3
T3493 4030-4032 IN denotes on
T3494 4033-4038 NN denotes MMU17
T3495 4038-4039 -RRB- denotes )
T3496 4040-4045 WP$ denotes whose
T3497 4046-4056 NN denotes expression
T3498 4057-4060 VBD denotes was
T3499 4061-4072 JJ denotes independent
T3500 4073-4075 IN denotes of
T3501 4076-4079 DT denotes the
T3503 4080-4082 NN denotes hg
T3502 4083-4088 NN denotes locus
T3504 4088-4089 . denotes .
T3505 4089-4190 sentence denotes In the current study we have developed speed congenic strains to isolate all the aforementioned QTL.
T3506 4090-4092 IN denotes In
T3508 4093-4096 DT denotes the
T3510 4097-4104 JJ denotes current
T3509 4105-4110 NN denotes study
T3511 4111-4113 PRP denotes we
T3512 4114-4118 VBP denotes have
T3507 4119-4128 VBN denotes developed
T3513 4129-4134 NN denotes speed
T3514 4135-4143 JJ denotes congenic
T3515 4144-4151 NNS denotes strains
T3516 4152-4154 TO denotes to
T3517 4155-4162 VB denotes isolate
T3518 4163-4166 PDT denotes all
T3520 4167-4170 DT denotes the
T3521 4171-4185 JJ denotes aforementioned
T3519 4186-4189 NN denotes QTL
T3522 4189-4190 . denotes .
T3523 4190-4418 sentence denotes Single strains on an HG background were created for each chromosomal region outside of MMU2, while a comprehensive panel of overlapping strains with identical donor regions on both B6 and HG backgrounds were developed for MMU2.
T3524 4191-4197 JJ denotes Single
T3525 4198-4205 NNS denotes strains
T3527 4206-4208 IN denotes on
T3528 4209-4211 DT denotes an
T3530 4212-4214 NN denotes HG
T3529 4215-4225 NN denotes background
T3531 4226-4230 VBD denotes were
T3526 4231-4238 VBN denotes created
T3532 4239-4242 IN denotes for
T3533 4243-4247 DT denotes each
T3535 4248-4259 JJ denotes chromosomal
T3534 4260-4266 NN denotes region
T3536 4267-4274 IN denotes outside
T3537 4275-4277 IN denotes of
T3538 4278-4282 NN denotes MMU2
T3539 4282-4284 , denotes ,
T3540 4284-4289 IN denotes while
T3542 4290-4291 DT denotes a
T3544 4292-4305 JJ denotes comprehensive
T3543 4306-4311 NN denotes panel
T3545 4312-4314 IN denotes of
T3546 4315-4326 VBG denotes overlapping
T3547 4327-4334 NNS denotes strains
T3548 4335-4339 IN denotes with
T3549 4340-4349 JJ denotes identical
T3551 4350-4355 NN denotes donor
T3550 4356-4363 NNS denotes regions
T3552 4364-4366 IN denotes on
T3553 4367-4371 CC denotes both
T3554 4372-4374 NN denotes B6
T3556 4375-4378 CC denotes and
T3557 4379-4381 NN denotes HG
T3555 4382-4393 NNS denotes backgrounds
T3558 4394-4398 VBD denotes were
T3541 4399-4408 VBN denotes developed
T3559 4409-4412 IN denotes for
T3560 4413-4417 NN denotes MMU2
T3561 4417-4418 . denotes .
T3562 4418-4521 sentence denotes The MMU2 panel was developed to confirm the presence of multiple QTL and test for QTL-hg interactions.
T3563 4419-4422 DT denotes The
T3565 4423-4427 NN denotes MMU2
T3564 4428-4433 NN denotes panel
T3567 4434-4437 VBD denotes was
T3566 4438-4447 VBN denotes developed
T3568 4448-4450 TO denotes to
T3569 4451-4458 VB denotes confirm
T3570 4459-4462 DT denotes the
T3571 4463-4471 NN denotes presence
T3572 4472-4474 IN denotes of
T3573 4475-4483 JJ denotes multiple
T3574 4484-4487 NN denotes QTL
T3575 4488-4491 CC denotes and
T3576 4492-4496 VB denotes test
T3577 4497-4500 IN denotes for
T3578 4501-4504 NN denotes QTL
T3580 4504-4505 HYPH denotes -
T3579 4505-4507 NN denotes hg
T3581 4508-4520 NNS denotes interactions
T3582 4520-4521 . denotes .
T3583 4521-4713 sentence denotes Additionally, based on the knowledge of potential QTL-hg interactions, genes involved in Gh signaling, whose genomic location overlapped hg modifier QTL on MMU2, 9, 11 and 17, were sequenced.
T3584 4522-4534 RB denotes Additionally
T3586 4534-4536 , denotes ,
T3587 4536-4541 VBN denotes based
T3588 4542-4544 IN denotes on
T3589 4545-4548 DT denotes the
T3590 4549-4558 NN denotes knowledge
T3591 4559-4561 IN denotes of
T3592 4562-4571 JJ denotes potential
T3594 4572-4575 NN denotes QTL
T3596 4575-4576 HYPH denotes -
T3595 4576-4578 NN denotes hg
T3593 4579-4591 NNS denotes interactions
T3597 4591-4593 , denotes ,
T3598 4593-4598 NNS denotes genes
T3599 4599-4607 VBN denotes involved
T3600 4608-4610 IN denotes in
T3601 4611-4613 NN denotes Gh
T3602 4614-4623 NN denotes signaling
T3603 4623-4625 , denotes ,
T3604 4625-4630 WP$ denotes whose
T3606 4631-4638 JJ denotes genomic
T3605 4639-4647 NN denotes location
T3607 4648-4658 VBD denotes overlapped
T3608 4659-4661 NN denotes hg
T3610 4662-4670 NN denotes modifier
T3609 4671-4674 NN denotes QTL
T3611 4675-4677 IN denotes on
T3612 4678-4681 NN denotes MMU
T3613 4681-4682 CD denotes 2
T3614 4682-4684 , denotes ,
T3615 4684-4685 CD denotes 9
T3616 4685-4687 , denotes ,
T3617 4687-4689 CD denotes 11
T3618 4690-4693 CC denotes and
T3619 4694-4696 CD denotes 17
T3620 4696-4698 , denotes ,
T3621 4698-4702 VBD denotes were
T3585 4703-4712 VBN denotes sequenced
T3622 4712-4713 . denotes .
T4080 4724-4729 NN denotes Speed
T4081 4730-4738 JJ denotes congenic
T4082 4739-4745 NN denotes strain
T4083 4746-4757 NN denotes development
T4084 4757-4907 sentence denotes Two speed congenic panels were created, the first comprehensively dissected MMU2 while the second isolated QTL on MMU1, 5, 8, 9, 11 and 17 (Table 1).
T4085 4758-4761 CD denotes Two
T4087 4762-4767 NN denotes speed
T4088 4768-4776 JJ denotes congenic
T4086 4777-4783 NNS denotes panels
T4090 4784-4788 VBD denotes were
T4089 4789-4796 VBN denotes created
T4091 4796-4798 , denotes ,
T4092 4798-4801 DT denotes the
T4093 4802-4807 JJ denotes first
T4095 4808-4823 RB denotes comprehensively
T4094 4824-4833 VBN denotes dissected
T4096 4834-4838 NN denotes MMU2
T4097 4839-4844 IN denotes while
T4099 4845-4848 DT denotes the
T4100 4849-4855 JJ denotes second
T4098 4856-4864 VBN denotes isolated
T4101 4865-4868 NN denotes QTL
T4102 4869-4871 IN denotes on
T4103 4872-4875 NN denotes MMU
T4104 4875-4876 CD denotes 1
T4105 4876-4878 , denotes ,
T4106 4878-4879 CD denotes 5
T4107 4879-4881 , denotes ,
T4108 4881-4882 CD denotes 8
T4109 4882-4884 , denotes ,
T4110 4884-4885 CD denotes 9
T4111 4885-4887 , denotes ,
T4112 4887-4889 CD denotes 11
T4113 4890-4893 CC denotes and
T4114 4894-4896 CD denotes 17
T4115 4897-4898 -LRB- denotes (
T4116 4898-4903 NN denotes Table
T4117 4904-4905 CD denotes 1
T4118 4905-4906 -RRB- denotes )
T4119 4906-4907 . denotes .
T4120 4907-5067 sentence denotes The MMU2 panel consisted of eight congenic strains developed by introgressing four overlapping donor regions onto both B6 and HG genetic backgrounds (Table 1).
T4121 4908-4911 DT denotes The
T4123 4912-4916 NN denotes MMU2
T4122 4917-4922 NN denotes panel
T4124 4923-4932 VBD denotes consisted
T4125 4933-4935 IN denotes of
T4126 4936-4941 CD denotes eight
T4128 4942-4950 JJ denotes congenic
T4127 4951-4958 NNS denotes strains
T4129 4959-4968 VBN denotes developed
T4130 4969-4971 IN denotes by
T4131 4972-4985 VBG denotes introgressing
T4132 4986-4990 CD denotes four
T4134 4991-5002 VBG denotes overlapping
T4135 5003-5008 NN denotes donor
T4133 5009-5016 NNS denotes regions
T4136 5017-5021 IN denotes onto
T4137 5022-5026 CC denotes both
T4138 5027-5029 NN denotes B6
T4140 5030-5033 CC denotes and
T4141 5034-5036 NN denotes HG
T4142 5037-5044 JJ denotes genetic
T4139 5045-5056 NNS denotes backgrounds
T4143 5057-5058 -LRB- denotes (
T4144 5058-5063 NN denotes Table
T4145 5064-5065 CD denotes 1
T4146 5065-5066 -RRB- denotes )
T4147 5066-5067 . denotes .
T4148 5067-5186 sentence denotes Single donor regions bred onto an HG background were created to isolate the remaining QTL on MMU1, 5, 8, 9, 11 and 17.
T4149 5068-5074 JJ denotes Single
T4151 5075-5080 NN denotes donor
T4150 5081-5088 NNS denotes regions
T4153 5089-5093 VBN denotes bred
T4154 5094-5098 IN denotes onto
T4155 5099-5101 DT denotes an
T4157 5102-5104 NN denotes HG
T4156 5105-5115 NN denotes background
T4158 5116-5120 VBD denotes were
T4152 5121-5128 VBN denotes created
T4159 5129-5131 TO denotes to
T4160 5132-5139 VB denotes isolate
T4161 5140-5143 DT denotes the
T4163 5144-5153 VBG denotes remaining
T4162 5154-5157 NN denotes QTL
T4164 5158-5160 IN denotes on
T4165 5161-5164 NN denotes MMU
T4166 5164-5165 CD denotes 1
T4167 5165-5167 , denotes ,
T4168 5167-5168 CD denotes 5
T4169 5168-5170 , denotes ,
T4170 5170-5171 CD denotes 8
T4171 5171-5173 , denotes ,
T4172 5173-5174 CD denotes 9
T4173 5174-5176 , denotes ,
T4174 5176-5178 CD denotes 11
T4175 5179-5182 CC denotes and
T4176 5183-5185 CD denotes 17
T4177 5185-5186 . denotes .
T4178 5186-5382 sentence denotes Implementation of a speed congenic approach using marker-assisted breeding with 79 genome-wide microsatellite markers accelerated production of all strains [5,6] (Additional File 1 and Figure 1).
T4179 5187-5201 NN denotes Implementation
T4181 5202-5204 IN denotes of
T4182 5205-5206 DT denotes a
T4184 5207-5212 NN denotes speed
T4185 5213-5221 JJ denotes congenic
T4183 5222-5230 NN denotes approach
T4186 5231-5236 VBG denotes using
T4187 5237-5243 NN denotes marker
T4189 5243-5244 HYPH denotes -
T4188 5244-5252 VBN denotes assisted
T4190 5253-5261 NN denotes breeding
T4191 5262-5266 IN denotes with
T4192 5267-5269 CD denotes 79
T4194 5270-5276 NN denotes genome
T4196 5276-5277 HYPH denotes -
T4195 5277-5281 JJ denotes wide
T4197 5282-5296 NN denotes microsatellite
T4193 5297-5304 NNS denotes markers
T4180 5305-5316 VBD denotes accelerated
T4198 5317-5327 NN denotes production
T4199 5328-5330 IN denotes of
T4200 5331-5334 DT denotes all
T4201 5335-5342 NNS denotes strains
T4202 5343-5344 -LRB- denotes [
T4204 5344-5345 CD denotes 5
T4205 5345-5346 , denotes ,
T4203 5346-5347 CD denotes 6
T4206 5347-5348 -RRB- denotes ]
T4207 5349-5350 -LRB- denotes (
T4209 5350-5360 JJ denotes Additional
T4208 5361-5365 NN denotes File
T4210 5366-5367 CD denotes 1
T4211 5368-5371 CC denotes and
T4212 5372-5378 NN denotes Figure
T4213 5379-5380 CD denotes 1
T4214 5380-5381 -RRB- denotes )
T4215 5381-5382 . denotes .
T4216 5382-5469 sentence denotes Strain abbreviations and genomic region isolated by each strain are listed in Table 1.
T4217 5383-5389 NN denotes Strain
T4218 5390-5403 NNS denotes abbreviations
T4220 5404-5407 CC denotes and
T4221 5408-5415 JJ denotes genomic
T4222 5416-5422 NN denotes region
T4223 5423-5431 VBN denotes isolated
T4224 5432-5434 IN denotes by
T4225 5435-5439 DT denotes each
T4226 5440-5446 NN denotes strain
T4227 5447-5450 VBP denotes are
T4219 5451-5457 VBN denotes listed
T4228 5458-5460 IN denotes in
T4229 5461-5466 NN denotes Table
T4230 5467-5468 CD denotes 1
T4231 5468-5469 . denotes .
T4232 5469-5713 sentence denotes In addition to both congenic panels, two control strains homozygous B6 (B6.CASTC; B6C) or HG (HG.CASTC; HGC) for all genome-wide markers genotyped were developed from the same cross (see Methods) and served as the basis for strain comparisons.
T4233 5470-5472 IN denotes In
T4235 5473-5481 NN denotes addition
T4236 5482-5484 IN denotes to
T4237 5485-5489 CC denotes both
T4239 5490-5498 JJ denotes congenic
T4238 5499-5505 NNS denotes panels
T4240 5505-5507 , denotes ,
T4241 5507-5510 CD denotes two
T4243 5511-5518 NN denotes control
T4242 5519-5526 NNS denotes strains
T4244 5527-5537 JJ denotes homozygous
T4245 5538-5540 NN denotes B6
T4246 5541-5542 -LRB- denotes (
T4247 5542-5550 NN denotes B6.CASTC
T4249 5550-5551 : denotes ;
T4248 5552-5555 NN denotes B6C
T4250 5555-5556 -RRB- denotes )
T4251 5557-5559 CC denotes or
T4252 5560-5562 NN denotes HG
T4253 5563-5564 -LRB- denotes (
T4254 5564-5572 NN denotes HG.CASTC
T4256 5572-5573 : denotes ;
T4255 5574-5577 NN denotes HGC
T4257 5577-5578 -RRB- denotes )
T4258 5579-5582 IN denotes for
T4259 5583-5586 DT denotes all
T4261 5587-5593 NN denotes genome
T4263 5593-5594 HYPH denotes -
T4262 5594-5598 JJ denotes wide
T4260 5599-5606 NNS denotes markers
T4264 5607-5616 VBN denotes genotyped
T4265 5617-5621 VBD denotes were
T4234 5622-5631 VBN denotes developed
T4266 5632-5636 IN denotes from
T4267 5637-5640 DT denotes the
T4269 5641-5645 JJ denotes same
T4268 5646-5651 NN denotes cross
T4270 5652-5653 -LRB- denotes (
T4271 5653-5656 VB denotes see
T4272 5657-5664 NNS denotes Methods
T4273 5664-5665 -RRB- denotes )
T4274 5666-5669 CC denotes and
T4275 5670-5676 VBD denotes served
T4276 5677-5679 IN denotes as
T4277 5680-5683 DT denotes the
T4278 5684-5689 NN denotes basis
T4279 5690-5693 IN denotes for
T4280 5694-5700 NN denotes strain
T4281 5701-5712 NNS denotes comparisons
T4282 5712-5713 . denotes .
T4283 5713-5815 sentence denotes After stabilizing each congenic, 12 of 14 were phenotypically characterized for growth and adiposity.
T4284 5714-5719 IN denotes After
T4286 5720-5731 VBG denotes stabilizing
T4287 5732-5736 DT denotes each
T4288 5737-5745 JJ denotes congenic
T4289 5745-5747 , denotes ,
T4290 5747-5749 CD denotes 12
T4292 5750-5752 IN denotes of
T4291 5753-5755 CD denotes 14
T4293 5756-5760 VBD denotes were
T4294 5761-5775 RB denotes phenotypically
T4285 5776-5789 VBN denotes characterized
T4295 5790-5793 IN denotes for
T4296 5794-5800 NN denotes growth
T4297 5801-5804 CC denotes and
T4298 5805-5814 NN denotes adiposity
T4299 5814-5815 . denotes .
T4300 5815-5893 sentence denotes The HG2D and HG5 strains were not characterized due to reproductive problems.
T4301 5816-5819 DT denotes The
T4303 5820-5824 NN denotes HG2D
T4304 5825-5828 CC denotes and
T4305 5829-5832 NN denotes HG5
T4302 5833-5840 NNS denotes strains
T4307 5841-5845 VBD denotes were
T4308 5846-5849 RB denotes not
T4306 5850-5863 VBN denotes characterized
T4309 5864-5867 IN denotes due
T4310 5868-5870 IN denotes to
T4311 5871-5883 JJ denotes reproductive
T4312 5884-5892 NNS denotes problems
T4313 5892-5893 . denotes .
T4314 5893-6026 sentence denotes The recombinant end points for all strains were refined using microsatellite markers flanking each donor region (Additional File 2).
T4315 5894-5897 DT denotes The
T4317 5898-5909 JJ denotes recombinant
T4318 5910-5913 NN denotes end
T4316 5914-5920 NNS denotes points
T4320 5921-5924 IN denotes for
T4321 5925-5928 DT denotes all
T4322 5929-5936 NNS denotes strains
T4323 5937-5941 VBD denotes were
T4319 5942-5949 VBN denotes refined
T4324 5950-5955 VBG denotes using
T4325 5956-5970 NN denotes microsatellite
T4326 5971-5978 NNS denotes markers
T4327 5979-5987 VBG denotes flanking
T4328 5988-5992 DT denotes each
T4330 5993-5998 NN denotes donor
T4329 5999-6005 NN denotes region
T4331 6006-6007 -LRB- denotes (
T4333 6007-6017 JJ denotes Additional
T4332 6018-6022 NN denotes File
T4334 6023-6024 CD denotes 2
T4335 6024-6025 -RRB- denotes )
T4336 6025-6026 . denotes .
T6950 6028-6032 NN denotes MMU2
T6952 6033-6038 NN denotes speed
T6953 6039-6047 JJ denotes congenic
T6951 6048-6054 NN denotes strain
T6954 6055-6071 NN denotes characterization
T6955 6071-6221 sentence denotes Due to the overlapping nature of the MMU2 congenics, five distinct chromosomal regions (Regions I–V) were queried for the presence of QTL (Figure 2).
T6956 6072-6075 IN denotes Due
T6958 6076-6078 IN denotes to
T6959 6079-6082 DT denotes the
T6961 6083-6094 VBG denotes overlapping
T6960 6095-6101 NN denotes nature
T6962 6102-6104 IN denotes of
T6963 6105-6108 DT denotes the
T6965 6109-6113 NN denotes MMU2
T6964 6114-6123 NNS denotes congenics
T6966 6123-6125 , denotes ,
T6967 6125-6129 CD denotes five
T6969 6130-6138 JJ denotes distinct
T6970 6139-6150 JJ denotes chromosomal
T6968 6151-6158 NNS denotes regions
T6971 6159-6160 -LRB- denotes (
T6972 6160-6167 NNS denotes Regions
T6973 6168-6169 CD denotes I
T6974 6169-6170 SYM denotes –
T6975 6170-6171 CD denotes V
T6976 6171-6172 -RRB- denotes )
T6977 6173-6177 VBD denotes were
T6957 6178-6185 VBN denotes queried
T6978 6186-6189 IN denotes for
T6979 6190-6193 DT denotes the
T6980 6194-6202 NN denotes presence
T6981 6203-6205 IN denotes of
T6982 6206-6209 NN denotes QTL
T6983 6210-6211 -LRB- denotes (
T6984 6211-6217 NN denotes Figure
T6985 6218-6219 CD denotes 2
T6986 6219-6220 -RRB- denotes )
T6987 6220-6221 . denotes .
T6988 6221-6344 sentence denotes As a separate analysis we also tested for interactions between each donor region and the two distinct genetic backgrounds.
T6989 6222-6224 IN denotes As
T6991 6225-6226 DT denotes a
T6993 6227-6235 JJ denotes separate
T6992 6236-6244 NN denotes analysis
T6994 6245-6247 PRP denotes we
T6995 6248-6252 RB denotes also
T6990 6253-6259 VBN denotes tested
T6996 6260-6263 IN denotes for
T6997 6264-6276 NNS denotes interactions
T6998 6277-6284 IN denotes between
T6999 6285-6289 DT denotes each
T7001 6290-6295 NN denotes donor
T7000 6296-6302 NN denotes region
T7002 6303-6306 CC denotes and
T7003 6307-6310 DT denotes the
T7005 6311-6314 CD denotes two
T7006 6315-6323 JJ denotes distinct
T7007 6324-6331 JJ denotes genetic
T7004 6332-6343 NNS denotes backgrounds
T7008 6343-6344 . denotes .
T7009 6344-6494 sentence denotes The following sections describe the phenotypes for each B6.CAST and HG.CAST speed congenic strain as well as the results of the interaction analysis.
T7010 6345-6348 DT denotes The
T7012 6349-6358 JJ denotes following
T7011 6359-6367 NNS denotes sections
T7013 6368-6376 VBP denotes describe
T7014 6377-6380 DT denotes the
T7015 6381-6391 NNS denotes phenotypes
T7016 6392-6395 IN denotes for
T7017 6396-6400 DT denotes each
T7019 6401-6408 NN denotes B6.CAST
T7020 6409-6412 CC denotes and
T7021 6413-6420 NN denotes HG.CAST
T7022 6421-6426 NN denotes speed
T7023 6427-6435 JJ denotes congenic
T7018 6436-6442 NN denotes strain
T7024 6443-6445 RB denotes as
T7026 6446-6450 RB denotes well
T7025 6451-6453 IN denotes as
T7027 6454-6457 DT denotes the
T7028 6458-6465 NNS denotes results
T7029 6466-6468 IN denotes of
T7030 6469-6472 DT denotes the
T7032 6473-6484 NN denotes interaction
T7031 6485-6493 NN denotes analysis
T7033 6493-6494 . denotes .
T7034 6494-6531 sentence denotes B6.CAST MMU2 speed congenic strains
T7035 6496-6503 NN denotes B6.CAST
T7036 6504-6508 NN denotes MMU2
T7038 6509-6514 NN denotes speed
T7039 6515-6523 JJ denotes congenic
T7037 6524-6531 NNS denotes strains
T7040 6531-6652 sentence denotes The B62D strain exhibited the largest (P < 0.0001) decreases in body weight of any B6.CAST congenic (Additional File 3).
T7041 6532-6535 DT denotes The
T7043 6536-6540 NN denotes B62D
T7042 6541-6547 NN denotes strain
T7044 6548-6557 VBD denotes exhibited
T7045 6558-6561 DT denotes the
T7047 6562-6569 JJS denotes largest
T7048 6570-6571 -LRB- denotes (
T7050 6571-6572 NN denotes P
T7051 6573-6574 SYM denotes <
T7049 6575-6581 CD denotes 0.0001
T7052 6581-6582 -RRB- denotes )
T7046 6583-6592 NNS denotes decreases
T7053 6593-6595 IN denotes in
T7054 6596-6600 NN denotes body
T7055 6601-6607 NN denotes weight
T7056 6608-6610 IN denotes of
T7057 6611-6614 DT denotes any
T7058 6615-6622 NN denotes B6.CAST
T7059 6623-6631 JJ denotes congenic
T7060 6632-6633 -LRB- denotes (
T7062 6633-6643 JJ denotes Additional
T7061 6644-6648 NN denotes File
T7063 6649-6650 CD denotes 3
T7064 6650-6651 -RRB- denotes )
T7065 6651-6652 . denotes .
T7066 6652-6783 sentence denotes Both sexes had reductions in weight at 2 (2WK), 3 (3WK), 6 (6WK) and 9 (9WK) weeks of age compared to control B6C mice (Figure 3).
T7067 6653-6657 DT denotes Both
T7068 6658-6663 NNS denotes sexes
T7069 6664-6667 VBD denotes had
T7070 6668-6678 NNS denotes reductions
T7071 6679-6681 IN denotes in
T7072 6682-6688 NN denotes weight
T7073 6689-6691 IN denotes at
T7074 6692-6693 CD denotes 2
T7076 6694-6695 -LRB- denotes (
T7077 6695-6698 NN denotes 2WK
T7078 6698-6699 -RRB- denotes )
T7079 6699-6701 , denotes ,
T7080 6701-6702 CD denotes 3
T7081 6703-6704 -LRB- denotes (
T7082 6704-6707 NN denotes 3WK
T7083 6707-6708 -RRB- denotes )
T7084 6708-6710 , denotes ,
T7085 6710-6711 CD denotes 6
T7086 6712-6713 -LRB- denotes (
T7087 6713-6716 NN denotes 6WK
T7088 6716-6717 -RRB- denotes )
T7089 6718-6721 CC denotes and
T7090 6722-6723 CD denotes 9
T7091 6724-6725 -LRB- denotes (
T7092 6725-6728 NN denotes 9WK
T7093 6728-6729 -RRB- denotes )
T7075 6730-6735 NNS denotes weeks
T7094 6736-6738 IN denotes of
T7095 6739-6742 NN denotes age
T7096 6743-6751 VBN denotes compared
T7097 6752-6754 IN denotes to
T7098 6755-6762 NN denotes control
T7100 6763-6766 NN denotes B6C
T7099 6767-6771 NNS denotes mice
T7101 6772-6773 -LRB- denotes (
T7102 6773-6779 NN denotes Figure
T7103 6780-6781 CD denotes 3
T7104 6781-6782 -RRB- denotes )
T7105 6782-6783 . denotes .
T7106 6783-6965 sentence denotes Despite large decreases in body weight, no differences in growth rates (G26, weight gain from 2 to 6 weeks and G29, weight gain from 2 to 9 weeks) were observed (Additional File 3).
T7107 6784-6791 IN denotes Despite
T7109 6792-6797 JJ denotes large
T7110 6798-6807 NNS denotes decreases
T7111 6808-6810 IN denotes in
T7112 6811-6815 NN denotes body
T7113 6816-6822 NN denotes weight
T7114 6822-6824 , denotes ,
T7115 6824-6826 DT denotes no
T7116 6827-6838 NNS denotes differences
T7117 6839-6841 IN denotes in
T7118 6842-6848 NN denotes growth
T7119 6849-6854 NNS denotes rates
T7120 6855-6856 -LRB- denotes (
T7122 6856-6859 NN denotes G26
T7123 6859-6861 , denotes ,
T7124 6861-6867 NN denotes weight
T7121 6868-6872 NN denotes gain
T7125 6873-6877 IN denotes from
T7126 6878-6879 CD denotes 2
T7128 6880-6882 IN denotes to
T7127 6883-6884 CD denotes 6
T7129 6885-6890 NNS denotes weeks
T7130 6891-6894 CC denotes and
T7131 6895-6898 NN denotes G29
T7133 6898-6900 , denotes ,
T7134 6900-6906 NN denotes weight
T7132 6907-6911 NN denotes gain
T7135 6912-6916 IN denotes from
T7136 6917-6918 CD denotes 2
T7138 6919-6921 IN denotes to
T7137 6922-6923 CD denotes 9
T7139 6924-6929 NNS denotes weeks
T7140 6929-6930 -RRB- denotes )
T7141 6931-6935 VBD denotes were
T7108 6936-6944 VBN denotes observed
T7142 6945-6946 -LRB- denotes (
T7144 6946-6956 JJ denotes Additional
T7143 6957-6961 NN denotes File
T7145 6962-6963 CD denotes 3
T7146 6963-6964 -RRB- denotes )
T7147 6964-6965 . denotes .
T7148 6965-7137 sentence denotes Therefore, the B62D unique region (Region V) harbors either an early-growth QTL or maternal genotype effect which produces a distinct decrease in body weight prior to 2WK.
T7149 6966-6975 RB denotes Therefore
T7151 6975-6977 , denotes ,
T7152 6977-6980 DT denotes the
T7154 6981-6985 NN denotes B62D
T7155 6986-6992 JJ denotes unique
T7153 6993-6999 NN denotes region
T7156 7000-7001 -LRB- denotes (
T7157 7001-7007 NN denotes Region
T7158 7008-7009 CD denotes V
T7159 7009-7010 -RRB- denotes )
T7150 7011-7018 VBZ denotes harbors
T7160 7019-7025 CC denotes either
T7162 7026-7028 DT denotes an
T7163 7029-7034 JJ denotes early
T7165 7034-7035 HYPH denotes -
T7164 7035-7041 NN denotes growth
T7161 7042-7045 NN denotes QTL
T7166 7046-7048 CC denotes or
T7167 7049-7057 JJ denotes maternal
T7169 7058-7066 NN denotes genotype
T7168 7067-7073 NN denotes effect
T7170 7074-7079 WDT denotes which
T7171 7080-7088 VBZ denotes produces
T7172 7089-7090 DT denotes a
T7174 7091-7099 JJ denotes distinct
T7173 7100-7108 NN denotes decrease
T7175 7109-7111 IN denotes in
T7176 7112-7116 NN denotes body
T7177 7117-7123 NN denotes weight
T7178 7124-7129 JJ denotes prior
T7179 7130-7132 IN denotes to
T7180 7133-7136 NN denotes 2WK
T7181 7136-7137 . denotes .
T7182 7137-7226 sentence denotes These effects are evident in the growth curves for both sexes of each strain (Figure 3).
T7183 7138-7143 DT denotes These
T7184 7144-7151 NNS denotes effects
T7185 7152-7155 VBP denotes are
T7186 7156-7163 JJ denotes evident
T7187 7164-7166 IN denotes in
T7188 7167-7170 DT denotes the
T7190 7171-7177 NN denotes growth
T7189 7178-7184 NNS denotes curves
T7191 7185-7188 IN denotes for
T7192 7189-7193 DT denotes both
T7193 7194-7199 NNS denotes sexes
T7194 7200-7202 IN denotes of
T7195 7203-7207 DT denotes each
T7196 7208-7214 NN denotes strain
T7197 7215-7216 -LRB- denotes (
T7198 7216-7222 NN denotes Figure
T7199 7223-7224 CD denotes 3
T7200 7224-7225 -RRB- denotes )
T7201 7225-7226 . denotes .
T7202 7226-7353 sentence denotes Additionally, B62D mice displayed significantly shorter tail lengths despite no difference in naso-anal length (NA) (Table 2).
T7203 7227-7239 RB denotes Additionally
T7205 7239-7241 , denotes ,
T7206 7241-7245 NN denotes B62D
T7207 7246-7250 NNS denotes mice
T7204 7251-7260 VBD denotes displayed
T7208 7261-7274 RB denotes significantly
T7209 7275-7282 JJR denotes shorter
T7211 7283-7287 NN denotes tail
T7210 7288-7295 NNS denotes lengths
T7212 7296-7303 IN denotes despite
T7213 7304-7306 DT denotes no
T7214 7307-7317 NN denotes difference
T7215 7318-7320 IN denotes in
T7216 7321-7330 JJ denotes naso-anal
T7217 7331-7337 NN denotes length
T7218 7338-7339 -LRB- denotes (
T7219 7339-7341 NN denotes NA
T7220 7341-7342 -RRB- denotes )
T7221 7343-7344 -LRB- denotes (
T7222 7344-7349 NN denotes Table
T7223 7350-7351 CD denotes 2
T7224 7351-7352 -RRB- denotes )
T7225 7352-7353 . denotes .
T7226 7353-7603 sentence denotes In contrast, B62M mice displayed small decreases in body weights and growth (male 9WK was significant, female 6WK and 9WK were suggestive at P < 0.05) and significant decreases in NA (male P = 0.0152) and tail length (Additional File 3 and Table 2).
T7227 7354-7356 IN denotes In
T7229 7357-7365 NN denotes contrast
T7230 7365-7367 , denotes ,
T7231 7367-7371 NN denotes B62M
T7232 7372-7376 NNS denotes mice
T7228 7377-7386 VBD denotes displayed
T7233 7387-7392 JJ denotes small
T7234 7393-7402 NNS denotes decreases
T7235 7403-7405 IN denotes in
T7236 7406-7410 NN denotes body
T7237 7411-7418 NNS denotes weights
T7238 7419-7422 CC denotes and
T7239 7423-7429 NN denotes growth
T7240 7430-7431 -LRB- denotes (
T7242 7431-7435 JJ denotes male
T7243 7436-7439 NN denotes 9WK
T7244 7440-7443 VBD denotes was
T7245 7444-7455 JJ denotes significant
T7246 7455-7457 , denotes ,
T7247 7457-7463 JJ denotes female
T7248 7464-7467 NN denotes 6WK
T7249 7468-7471 CC denotes and
T7250 7472-7475 NN denotes 9WK
T7241 7476-7480 VBD denotes were
T7251 7481-7491 JJ denotes suggestive
T7252 7492-7494 IN denotes at
T7253 7495-7496 NN denotes P
T7255 7497-7498 SYM denotes <
T7254 7499-7503 CD denotes 0.05
T7256 7503-7504 -RRB- denotes )
T7257 7505-7508 CC denotes and
T7258 7509-7520 JJ denotes significant
T7259 7521-7530 NNS denotes decreases
T7260 7531-7533 IN denotes in
T7261 7534-7536 NN denotes NA
T7263 7537-7538 -LRB- denotes (
T7265 7538-7542 JJ denotes male
T7266 7543-7544 NN denotes P
T7267 7545-7546 SYM denotes =
T7264 7547-7553 CD denotes 0.0152
T7268 7553-7554 -RRB- denotes )
T7269 7555-7558 CC denotes and
T7270 7559-7563 NN denotes tail
T7262 7564-7570 NN denotes length
T7271 7571-7572 -LRB- denotes (
T7273 7572-7582 JJ denotes Additional
T7272 7583-7587 NN denotes File
T7274 7588-7589 CD denotes 3
T7275 7590-7593 CC denotes and
T7276 7594-7599 NN denotes Table
T7277 7600-7601 CD denotes 2
T7278 7601-7602 -RRB- denotes )
T7279 7602-7603 . denotes .
T7280 7603-7774 sentence denotes The decrease in NA in B62M mice is surprising since the 2M donor region is entirely nested within the 2D donor region and B62D mice showed no difference in NA (Figure 2).
T7281 7604-7607 DT denotes The
T7282 7608-7616 NN denotes decrease
T7284 7617-7619 IN denotes in
T7285 7620-7622 NN denotes NA
T7286 7623-7625 IN denotes in
T7287 7626-7630 NN denotes B62M
T7288 7631-7635 NNS denotes mice
T7283 7636-7638 VBZ denotes is
T7289 7639-7649 JJ denotes surprising
T7290 7650-7655 IN denotes since
T7292 7656-7659 DT denotes the
T7294 7660-7662 NN denotes 2M
T7295 7663-7668 NN denotes donor
T7293 7669-7675 NN denotes region
T7296 7676-7678 VBZ denotes is
T7297 7679-7687 RB denotes entirely
T7291 7688-7694 VBN denotes nested
T7298 7695-7701 IN denotes within
T7299 7702-7705 DT denotes the
T7301 7706-7708 NN denotes 2D
T7302 7709-7714 NN denotes donor
T7300 7715-7721 NN denotes region
T7303 7722-7725 CC denotes and
T7304 7726-7730 NN denotes B62D
T7305 7731-7735 NNS denotes mice
T7306 7736-7742 VBD denotes showed
T7307 7743-7745 DT denotes no
T7308 7746-7756 NN denotes difference
T7309 7757-7759 IN denotes in
T7310 7760-7762 NN denotes NA
T7311 7763-7764 -LRB- denotes (
T7312 7764-7770 NN denotes Figure
T7313 7771-7772 CD denotes 2
T7314 7772-7773 -RRB- denotes )
T7315 7773-7774 . denotes .
T7316 7774-7847 sentence denotes These data indicate the presence of three QTL with the 2D unique region.
T7317 7775-7780 DT denotes These
T7318 7781-7785 NNS denotes data
T7319 7786-7794 VBP denotes indicate
T7320 7795-7798 DT denotes the
T7321 7799-7807 NN denotes presence
T7322 7808-7810 IN denotes of
T7323 7811-7816 CD denotes three
T7324 7817-7820 NN denotes QTL
T7325 7821-7825 IN denotes with
T7326 7826-7829 DT denotes the
T7328 7830-7832 NN denotes 2D
T7329 7833-7839 JJ denotes unique
T7327 7840-7846 NN denotes region
T7330 7846-7847 . denotes .
T7331 7847-7968 sentence denotes Two of which are disjoined by the B62M and B62D strains and additively decrease body weight and tail length, but not NA.
T7332 7848-7851 CD denotes Two
T7334 7852-7854 IN denotes of
T7335 7855-7860 WDT denotes which
T7336 7861-7864 VBP denotes are
T7333 7865-7874 VBN denotes disjoined
T7337 7875-7877 IN denotes by
T7338 7878-7881 DT denotes the
T7340 7882-7886 NN denotes B62M
T7341 7887-7890 CC denotes and
T7342 7891-7895 NN denotes B62D
T7339 7896-7903 NNS denotes strains
T7343 7904-7907 CC denotes and
T7344 7908-7918 RB denotes additively
T7345 7919-7927 VBP denotes decrease
T7346 7928-7932 NN denotes body
T7347 7933-7939 NN denotes weight
T7348 7940-7943 CC denotes and
T7349 7944-7948 NN denotes tail
T7350 7949-7955 NN denotes length
T7351 7955-7957 , denotes ,
T7352 7957-7960 CC denotes but
T7353 7961-7964 RB denotes not
T7354 7965-7967 NN denotes NA
T7355 7967-7968 . denotes .
T7356 7968-8111 sentence denotes The third QTL, located within the B62D unique region (Region V), increases NA canceling the effects of the B62M QTL (Region IV) decreasing NA.
T7357 7969-7972 DT denotes The
T7359 7973-7978 JJ denotes third
T7358 7979-7982 NN denotes QTL
T7361 7982-7984 , denotes ,
T7362 7984-7991 VBN denotes located
T7363 7992-7998 IN denotes within
T7364 7999-8002 DT denotes the
T7366 8003-8007 NN denotes B62D
T7367 8008-8014 JJ denotes unique
T7365 8015-8021 NN denotes region
T7368 8022-8023 -LRB- denotes (
T7369 8023-8029 NN denotes Region
T7370 8030-8031 CD denotes V
T7371 8031-8032 -RRB- denotes )
T7372 8032-8034 , denotes ,
T7360 8034-8043 VBZ denotes increases
T7373 8044-8046 NN denotes NA
T7374 8047-8056 VBG denotes canceling
T7375 8057-8060 DT denotes the
T7376 8061-8068 NNS denotes effects
T7377 8069-8071 IN denotes of
T7378 8072-8075 DT denotes the
T7380 8076-8080 NN denotes B62M
T7379 8081-8084 NN denotes QTL
T7382 8085-8086 -LRB- denotes (
T7383 8086-8092 NN denotes Region
T7384 8093-8095 CD denotes IV
T7385 8095-8096 -RRB- denotes )
T7381 8097-8107 VBG denotes decreasing
T7386 8108-8110 NN denotes NA
T7387 8110-8111 . denotes .
T7388 8111-8249 sentence denotes B62PM females had decreases in all growth-related traits except 2WK and 3WK, while no differences were seen in males (Additional File 3).
T7389 8112-8117 NN denotes B62PM
T7390 8118-8125 NNS denotes females
T7391 8126-8129 VBD denotes had
T7392 8130-8139 NNS denotes decreases
T7393 8140-8142 IN denotes in
T7394 8143-8146 DT denotes all
T7396 8147-8153 NN denotes growth
T7398 8153-8154 HYPH denotes -
T7397 8154-8161 VBN denotes related
T7395 8162-8168 NNS denotes traits
T7399 8169-8175 IN denotes except
T7400 8176-8179 NN denotes 2WK
T7401 8180-8183 CC denotes and
T7402 8184-8187 NN denotes 3WK
T7403 8187-8189 , denotes ,
T7404 8189-8194 IN denotes while
T7406 8195-8197 DT denotes no
T7407 8198-8209 NNS denotes differences
T7408 8210-8214 VBD denotes were
T7405 8215-8219 VBN denotes seen
T7409 8220-8222 IN denotes in
T7410 8223-8228 NNS denotes males
T7411 8229-8230 -LRB- denotes (
T7413 8230-8240 JJ denotes Additional
T7412 8241-8245 NN denotes File
T7414 8246-8247 CD denotes 3
T7415 8247-8248 -RRB- denotes )
T7416 8248-8249 . denotes .
T7417 8249-8439 sentence denotes Similarly, only B62P females and not males showed significant decreases in 9WK, G26 and G29 (Additional File 3), indicating these two strains share a female specific growth QTL (Region II).
T7418 8250-8259 RB denotes Similarly
T7420 8259-8261 , denotes ,
T7421 8261-8265 RB denotes only
T7423 8266-8270 NN denotes B62P
T7422 8271-8278 NNS denotes females
T7424 8279-8282 CC denotes and
T7425 8283-8286 RB denotes not
T7426 8287-8292 NNS denotes males
T7419 8293-8299 VBD denotes showed
T7427 8300-8311 JJ denotes significant
T7428 8312-8321 NNS denotes decreases
T7429 8322-8324 IN denotes in
T7430 8325-8328 NN denotes 9WK
T7431 8328-8330 , denotes ,
T7432 8330-8333 NN denotes G26
T7433 8334-8337 CC denotes and
T7434 8338-8341 NN denotes G29
T7435 8342-8343 -LRB- denotes (
T7437 8343-8353 JJ denotes Additional
T7436 8354-8358 NN denotes File
T7438 8359-8360 CD denotes 3
T7439 8360-8361 -RRB- denotes )
T7440 8361-8363 , denotes ,
T7441 8363-8373 VBG denotes indicating
T7442 8374-8379 DT denotes these
T7444 8380-8383 CD denotes two
T7443 8384-8391 NNS denotes strains
T7445 8392-8397 VBP denotes share
T7446 8398-8399 DT denotes a
T7448 8400-8406 JJ denotes female
T7449 8407-8415 JJ denotes specific
T7450 8416-8422 NN denotes growth
T7447 8423-8426 NN denotes QTL
T7451 8427-8428 -LRB- denotes (
T7452 8428-8434 NN denotes Region
T7453 8435-8437 CD denotes II
T7454 8437-8438 -RRB- denotes )
T7455 8438-8439 . denotes .
T7456 8439-8576 sentence denotes In the original genome scan body fat percentage as determined by chemical compositional analysis was not linked to markers on MMU2 [24].
T7457 8440-8442 IN denotes In
T7459 8443-8446 DT denotes the
T7461 8447-8455 JJ denotes original
T7462 8456-8462 NN denotes genome
T7460 8463-8467 NN denotes scan
T7463 8468-8472 NN denotes body
T7464 8473-8476 NN denotes fat
T7465 8477-8487 NN denotes percentage
T7466 8488-8490 IN denotes as
T7467 8491-8501 VBN denotes determined
T7468 8502-8504 IN denotes by
T7469 8505-8513 JJ denotes chemical
T7471 8514-8527 JJ denotes compositional
T7470 8528-8536 NN denotes analysis
T7472 8537-8540 VBD denotes was
T7473 8541-8544 RB denotes not
T7458 8545-8551 VBN denotes linked
T7474 8552-8554 IN denotes to
T7475 8555-8562 NNS denotes markers
T7476 8563-8565 IN denotes on
T7477 8566-8570 NN denotes MMU2
T7478 8571-8572 -LRB- denotes [
T7479 8572-8574 CD denotes 24
T7480 8574-8575 -RRB- denotes ]
T7481 8575-8576 . denotes .
T7482 8576-8789 sentence denotes However, since numerous obesity QTL have been found on MMU2 [2], some of which were discovered in B6 by CAST crosses [9,25], we chose to measure dissected fat pad weights as a more sensitive measure of adiposity.
T7483 8577-8584 RB denotes However
T7485 8584-8586 , denotes ,
T7486 8586-8591 IN denotes since
T7488 8592-8600 JJ denotes numerous
T7490 8601-8608 NN denotes obesity
T7489 8609-8612 NN denotes QTL
T7491 8613-8617 VBP denotes have
T7492 8618-8622 VBN denotes been
T7487 8623-8628 VBN denotes found
T7493 8629-8631 IN denotes on
T7494 8632-8636 NN denotes MMU2
T7495 8637-8638 -LRB- denotes [
T7496 8638-8639 CD denotes 2
T7497 8639-8640 -RRB- denotes ]
T7498 8640-8642 , denotes ,
T7499 8642-8646 DT denotes some
T7501 8647-8649 IN denotes of
T7502 8650-8655 WDT denotes which
T7503 8656-8660 VBD denotes were
T7500 8661-8671 VBN denotes discovered
T7504 8672-8674 IN denotes in
T7505 8675-8677 NN denotes B6
T7506 8678-8680 IN denotes by
T7507 8681-8685 NN denotes CAST
T7508 8686-8693 NNS denotes crosses
T7509 8694-8695 -LRB- denotes [
T7511 8695-8696 CD denotes 9
T7512 8696-8697 , denotes ,
T7510 8697-8699 CD denotes 25
T7513 8699-8700 -RRB- denotes ]
T7514 8700-8702 , denotes ,
T7515 8702-8704 PRP denotes we
T7484 8705-8710 VBD denotes chose
T7516 8711-8713 TO denotes to
T7517 8714-8721 VB denotes measure
T7518 8722-8731 VBN denotes dissected
T7520 8732-8735 NN denotes fat
T7521 8736-8739 NN denotes pad
T7519 8740-8747 NNS denotes weights
T7522 8748-8750 IN denotes as
T7523 8751-8752 DT denotes a
T7525 8753-8757 RBR denotes more
T7526 8758-8767 JJ denotes sensitive
T7524 8768-8775 NN denotes measure
T7527 8776-8778 IN denotes of
T7528 8779-8788 NN denotes adiposity
T7529 8788-8789 . denotes .
T7530 8789-9087 sentence denotes Table 2 lists the weights of gonadal (GFP), femoral (FFP), mesenteric (MFP) and retroperitoneal (RFP) fat pads, along with total fat pad weight (sum of the four fat pads), adiposity index (AI = TF/weight at sacrifice (WSAC)) and body mass index (BMI = WSAC/NA2 *100) for each MMU2 congenic strain.
T7531 8790-8795 NN denotes Table
T7533 8796-8797 CD denotes 2
T7532 8798-8803 VBZ denotes lists
T7534 8804-8807 DT denotes the
T7535 8808-8815 NNS denotes weights
T7536 8816-8818 IN denotes of
T7537 8819-8826 JJ denotes gonadal
T7539 8827-8828 -LRB- denotes (
T7540 8828-8831 NN denotes GFP
T7541 8831-8832 -RRB- denotes )
T7542 8832-8834 , denotes ,
T7543 8834-8841 JJ denotes femoral
T7544 8842-8843 -LRB- denotes (
T7545 8843-8846 NN denotes FFP
T7546 8846-8847 -RRB- denotes )
T7547 8847-8849 , denotes ,
T7548 8849-8859 JJ denotes mesenteric
T7549 8860-8861 -LRB- denotes (
T7550 8861-8864 NN denotes MFP
T7551 8864-8865 -RRB- denotes )
T7552 8866-8869 CC denotes and
T7553 8870-8885 JJ denotes retroperitoneal
T7554 8886-8887 -LRB- denotes (
T7555 8887-8890 NN denotes RFP
T7556 8890-8891 -RRB- denotes )
T7557 8892-8895 NN denotes fat
T7538 8896-8900 NNS denotes pads
T7558 8900-8902 , denotes ,
T7559 8902-8907 IN denotes along
T7560 8908-8912 IN denotes with
T7561 8913-8918 JJ denotes total
T7563 8919-8922 NN denotes fat
T7564 8923-8926 NN denotes pad
T7562 8927-8933 NN denotes weight
T7565 8934-8935 -LRB- denotes (
T7566 8935-8938 NN denotes sum
T7567 8939-8941 IN denotes of
T7568 8942-8945 DT denotes the
T7570 8946-8950 CD denotes four
T7571 8951-8954 NN denotes fat
T7569 8955-8959 NNS denotes pads
T7572 8959-8960 -RRB- denotes )
T7573 8960-8962 , denotes ,
T7574 8962-8971 NN denotes adiposity
T7575 8972-8977 NN denotes index
T7576 8978-8979 -LRB- denotes (
T7578 8979-8981 NN denotes AI
T7580 8982-8983 SYM denotes =
T7579 8984-8986 NN denotes TF
T7581 8986-8987 SYM denotes /
T7582 8987-8993 NN denotes weight
T7583 8994-8996 IN denotes at
T7584 8997-9006 NN denotes sacrifice
T7585 9007-9008 -LRB- denotes (
T7577 9008-9012 NN denotes WSAC
T7586 9012-9013 -RRB- denotes )
T7587 9013-9014 -RRB- denotes )
T7588 9015-9018 CC denotes and
T7589 9019-9023 NN denotes body
T7591 9024-9028 NN denotes mass
T7590 9029-9034 NN denotes index
T7592 9035-9036 -LRB- denotes (
T7594 9036-9039 NN denotes BMI
T7595 9040-9041 SYM denotes =
T7593 9042-9046 NN denotes WSAC
T7596 9046-9047 SYM denotes /
T7597 9047-9050 NN denotes NA2
T7598 9051-9052 SYM denotes *
T7599 9052-9055 NN denotes 100
T7600 9055-9056 -RRB- denotes )
T7601 9057-9060 IN denotes for
T7602 9061-9065 DT denotes each
T7604 9066-9070 NN denotes MMU2
T7605 9071-9079 JJ denotes congenic
T7603 9080-9086 NN denotes strain
T7606 9086-9087 . denotes .
T7607 9087-9200 sentence denotes Similar to large differences in body weight the B62D strain displayed highly significant decreases in adiposity.
T7608 9088-9095 JJ denotes Similar
T7610 9096-9098 IN denotes to
T7611 9099-9104 JJ denotes large
T7612 9105-9116 NNS denotes differences
T7613 9117-9119 IN denotes in
T7614 9120-9124 NN denotes body
T7615 9125-9131 NN denotes weight
T7616 9132-9135 DT denotes the
T7618 9136-9140 NN denotes B62D
T7617 9141-9147 NN denotes strain
T7609 9148-9157 VBD denotes displayed
T7619 9158-9164 RB denotes highly
T7620 9165-9176 JJ denotes significant
T7621 9177-9186 NNS denotes decreases
T7622 9187-9189 IN denotes in
T7623 9190-9199 NN denotes adiposity
T7624 9199-9200 . denotes .
T7625 9200-9287 sentence denotes B62D was the only strain where both sexes had significant decreases in TF, AI and BMI.
T7626 9201-9205 NN denotes B62D
T7627 9206-9209 VBD denotes was
T7628 9210-9213 DT denotes the
T7630 9214-9218 JJ denotes only
T7629 9219-9225 NN denotes strain
T7631 9226-9231 WRB denotes where
T7633 9232-9236 DT denotes both
T7634 9237-9242 NNS denotes sexes
T7632 9243-9246 VBD denotes had
T7635 9247-9258 JJ denotes significant
T7636 9259-9268 NNS denotes decreases
T7637 9269-9271 IN denotes in
T7638 9272-9274 NN denotes TF
T7639 9274-9276 , denotes ,
T7640 9276-9278 NN denotes AI
T7641 9279-9282 CC denotes and
T7642 9283-9286 NN denotes BMI
T7643 9286-9287 . denotes .
T7644 9287-9352 sentence denotes Interestingly, no difference in adiposity was seen in B62M mice.
T7645 9288-9301 RB denotes Interestingly
T7647 9301-9303 , denotes ,
T7648 9303-9305 DT denotes no
T7649 9306-9316 NN denotes difference
T7650 9317-9319 IN denotes in
T7651 9320-9329 NN denotes adiposity
T7652 9330-9333 VBD denotes was
T7646 9334-9338 VBN denotes seen
T7653 9339-9341 IN denotes in
T7654 9342-9346 NN denotes B62M
T7655 9347-9351 NNS denotes mice
T7656 9351-9352 . denotes .
T7657 9352-9455 sentence denotes This discordance indicates the leanness promoting QTL is located in the B62D unique region (Region V).
T7658 9353-9357 DT denotes This
T7659 9358-9369 NN denotes discordance
T7660 9370-9379 VBZ denotes indicates
T7661 9380-9383 DT denotes the
T7663 9384-9392 NN denotes leanness
T7664 9393-9402 VBG denotes promoting
T7662 9403-9406 NN denotes QTL
T7666 9407-9409 VBZ denotes is
T7665 9410-9417 VBN denotes located
T7667 9418-9420 IN denotes in
T7668 9421-9424 DT denotes the
T7670 9425-9429 NN denotes B62D
T7671 9430-9436 JJ denotes unique
T7669 9437-9443 NN denotes region
T7672 9444-9445 -LRB- denotes (
T7673 9445-9451 NN denotes Region
T7674 9452-9453 CD denotes V
T7675 9453-9454 -RRB- denotes )
T7676 9454-9455 . denotes .
T7677 9455-9561 sentence denotes Only minor differences in various fat pad weights were observed for the B62P and B62PM strains (Table 2).
T7678 9456-9460 RB denotes Only
T7680 9461-9466 JJ denotes minor
T7679 9467-9478 NNS denotes differences
T7682 9479-9481 IN denotes in
T7683 9482-9489 JJ denotes various
T7685 9490-9493 NN denotes fat
T7686 9494-9497 NN denotes pad
T7684 9498-9505 NNS denotes weights
T7687 9506-9510 VBD denotes were
T7681 9511-9519 VBN denotes observed
T7688 9520-9523 IN denotes for
T7689 9524-9527 DT denotes the
T7691 9528-9532 NN denotes B62P
T7692 9533-9536 CC denotes and
T7693 9537-9542 NN denotes B62PM
T7690 9543-9550 NNS denotes strains
T7694 9551-9552 -LRB- denotes (
T7695 9552-9557 NN denotes Table
T7696 9558-9559 CD denotes 2
T7697 9559-9560 -RRB- denotes )
T7698 9560-9561 . denotes .
T7699 9561-9596 sentence denotes HG.CAST MMU2 speed congenic panel
T7700 9563-9570 NN denotes HG.CAST
T7701 9571-9575 NN denotes MMU2
T7703 9576-9581 NN denotes speed
T7704 9582-9590 JJ denotes congenic
T7702 9591-9596 NN denotes panel
T7705 9596-9730 sentence denotes HG2P and HG2PM mice of both sexes displayed significant decreases in post-weaning body weights and growth rates (Additional Table 3).
T7706 9597-9601 NN denotes HG2P
T7708 9602-9605 CC denotes and
T7709 9606-9611 NN denotes HG2PM
T7707 9612-9616 NNS denotes mice
T7711 9617-9619 IN denotes of
T7712 9620-9624 DT denotes both
T7713 9625-9630 NNS denotes sexes
T7710 9631-9640 VBD denotes displayed
T7714 9641-9652 JJ denotes significant
T7715 9653-9662 NNS denotes decreases
T7716 9663-9665 IN denotes in
T7717 9666-9678 JJ denotes post-weaning
T7719 9679-9683 NN denotes body
T7718 9684-9691 NNS denotes weights
T7720 9692-9695 CC denotes and
T7721 9696-9702 NN denotes growth
T7722 9703-9708 NNS denotes rates
T7723 9709-9710 -LRB- denotes (
T7725 9710-9720 JJ denotes Additional
T7724 9721-9726 NN denotes Table
T7726 9727-9728 CD denotes 3
T7727 9728-9729 -RRB- denotes )
T7728 9729-9730 . denotes .
T7729 9730-9841 sentence denotes In addition, the HG2M strain displayed highly significant decreases in length, similar to B62M mice (Table 2).
T7730 9731-9733 IN denotes In
T7732 9734-9742 NN denotes addition
T7733 9742-9744 , denotes ,
T7734 9744-9747 DT denotes the
T7736 9748-9752 NN denotes HG2M
T7735 9753-9759 NN denotes strain
T7731 9760-9769 VBD denotes displayed
T7737 9770-9776 RB denotes highly
T7738 9777-9788 JJ denotes significant
T7739 9789-9798 NNS denotes decreases
T7740 9799-9801 IN denotes in
T7741 9802-9808 NN denotes length
T7742 9808-9810 , denotes ,
T7743 9810-9817 JJ denotes similar
T7744 9818-9820 IN denotes to
T7745 9821-9825 NN denotes B62M
T7746 9826-9830 NNS denotes mice
T7747 9831-9832 -LRB- denotes (
T7748 9832-9837 NN denotes Table
T7749 9838-9839 CD denotes 2
T7750 9839-9840 -RRB- denotes )
T7751 9840-9841 . denotes .
T7752 9841-10053 sentence denotes These results indicate QTL within Region II shared between the HG2P and HG2PM strains decrease body size, weight gain and NA (only in females), while a QTL in the HG2M region significantly decreases tail length.
T7753 9842-9847 DT denotes These
T7754 9848-9855 NNS denotes results
T7755 9856-9864 VBP denotes indicate
T7756 9865-9868 NN denotes QTL
T7758 9869-9875 IN denotes within
T7759 9876-9882 NN denotes Region
T7760 9883-9885 CD denotes II
T7761 9886-9892 VBN denotes shared
T7762 9893-9900 IN denotes between
T7763 9901-9904 DT denotes the
T7765 9905-9909 NN denotes HG2P
T7766 9910-9913 CC denotes and
T7767 9914-9919 NN denotes HG2PM
T7764 9920-9927 NNS denotes strains
T7757 9928-9936 VBP denotes decrease
T7768 9937-9941 NN denotes body
T7769 9942-9946 NN denotes size
T7770 9946-9948 , denotes ,
T7771 9948-9954 NN denotes weight
T7772 9955-9959 NN denotes gain
T7773 9960-9963 CC denotes and
T7774 9964-9966 NN denotes NA
T7775 9967-9968 -LRB- denotes (
T7776 9968-9972 RB denotes only
T7777 9973-9975 IN denotes in
T7778 9976-9983 NNS denotes females
T7779 9983-9984 -RRB- denotes )
T7780 9984-9986 , denotes ,
T7781 9986-9991 IN denotes while
T7783 9992-9993 DT denotes a
T7784 9994-9997 NN denotes QTL
T7785 9998-10000 IN denotes in
T7786 10001-10004 DT denotes the
T7788 10005-10009 NN denotes HG2M
T7787 10010-10016 NN denotes region
T7789 10017-10030 RB denotes significantly
T7782 10031-10040 VBZ denotes decreases
T7790 10041-10045 NN denotes tail
T7791 10046-10052 NN denotes length
T7792 10052-10053 . denotes .
T7793 10053-10181 sentence denotes Similar to growth traits a general decrease in GFP, MFP, RFP, TF and AI were seen in HG2P and HG2PM mice (Region II) (Table 2).
T7794 10054-10061 JJ denotes Similar
T7796 10062-10064 IN denotes to
T7797 10065-10071 NN denotes growth
T7798 10072-10078 NNS denotes traits
T7799 10079-10080 DT denotes a
T7801 10081-10088 JJ denotes general
T7800 10089-10097 NN denotes decrease
T7802 10098-10100 IN denotes in
T7803 10101-10104 NN denotes GFP
T7804 10104-10106 , denotes ,
T7805 10106-10109 NN denotes MFP
T7806 10109-10111 , denotes ,
T7807 10111-10114 NN denotes RFP
T7808 10114-10116 , denotes ,
T7809 10116-10118 NN denotes TF
T7810 10119-10122 CC denotes and
T7811 10123-10125 NN denotes AI
T7812 10126-10130 VBD denotes were
T7795 10131-10135 VBN denotes seen
T7813 10136-10138 IN denotes in
T7814 10139-10143 NN denotes HG2P
T7816 10144-10147 CC denotes and
T7817 10148-10153 NN denotes HG2PM
T7815 10154-10158 NNS denotes mice
T7818 10159-10160 -LRB- denotes (
T7819 10160-10166 NN denotes Region
T7820 10167-10169 CD denotes II
T7821 10169-10170 -RRB- denotes )
T7822 10171-10172 -LRB- denotes (
T7823 10172-10177 NN denotes Table
T7824 10178-10179 CD denotes 2
T7825 10179-10180 -RRB- denotes )
T7826 10180-10181 . denotes .
T7827 10181-10295 sentence denotes These differences in adiposity are likely pleiotropic effects of the growth QTL shared between these two strains.
T7828 10182-10187 DT denotes These
T7829 10188-10199 NNS denotes differences
T7831 10200-10202 IN denotes in
T7832 10203-10212 NN denotes adiposity
T7830 10213-10216 VBP denotes are
T7833 10217-10223 RB denotes likely
T7834 10224-10235 JJ denotes pleiotropic
T7835 10236-10243 NNS denotes effects
T7836 10244-10246 IN denotes of
T7837 10247-10250 DT denotes the
T7839 10251-10257 NN denotes growth
T7838 10258-10261 NN denotes QTL
T7840 10262-10268 VBN denotes shared
T7841 10269-10276 IN denotes between
T7842 10277-10282 DT denotes these
T7844 10283-10286 CD denotes two
T7843 10287-10294 NNS denotes strains
T7845 10294-10295 . denotes .
T7846 10295-10368 sentence denotes Surprisingly, HG2M mice displayed striking sex differences in adiposity.
T7847 10296-10308 RB denotes Surprisingly
T7849 10308-10310 , denotes ,
T7850 10310-10314 NN denotes HG2M
T7851 10315-10319 NNS denotes mice
T7848 10320-10329 VBD denotes displayed
T7852 10330-10338 JJ denotes striking
T7854 10339-10342 NN denotes sex
T7853 10343-10354 NNS denotes differences
T7855 10355-10357 IN denotes in
T7856 10358-10367 NN denotes adiposity
T7857 10367-10368 . denotes .
T7858 10368-10539 sentence denotes Males exhibited an increase in AI (P = 0.0256) with a decrease in BMI (P = 0.0462) and the exact opposite was seen in females (AI, P < 0.0001; BMI, P = 0.0425) (Table 2).
T7859 10369-10374 NNS denotes Males
T7860 10375-10384 VBD denotes exhibited
T7861 10385-10387 DT denotes an
T7862 10388-10396 NN denotes increase
T7863 10397-10399 IN denotes in
T7864 10400-10402 NN denotes AI
T7865 10403-10404 -LRB- denotes (
T7867 10404-10405 NN denotes P
T7868 10406-10407 SYM denotes =
T7866 10408-10414 CD denotes 0.0256
T7869 10414-10415 -RRB- denotes )
T7870 10416-10420 IN denotes with
T7871 10421-10422 DT denotes a
T7872 10423-10431 NN denotes decrease
T7873 10432-10434 IN denotes in
T7874 10435-10438 NN denotes BMI
T7875 10439-10440 -LRB- denotes (
T7877 10440-10441 NN denotes P
T7878 10442-10443 SYM denotes =
T7876 10444-10450 CD denotes 0.0462
T7879 10450-10451 -RRB- denotes )
T7880 10452-10455 CC denotes and
T7881 10456-10459 DT denotes the
T7883 10460-10465 JJ denotes exact
T7882 10466-10474 NN denotes opposite
T7885 10475-10478 VBD denotes was
T7884 10479-10483 VBN denotes seen
T7886 10484-10486 IN denotes in
T7887 10487-10494 NNS denotes females
T7888 10495-10496 -LRB- denotes (
T7890 10496-10498 NN denotes AI
T7892 10498-10500 , denotes ,
T7893 10500-10501 NN denotes P
T7894 10502-10503 SYM denotes <
T7891 10504-10510 CD denotes 0.0001
T7895 10510-10511 : denotes ;
T7896 10512-10515 NN denotes BMI
T7897 10515-10517 , denotes ,
T7898 10517-10518 NN denotes P
T7899 10519-10520 SYM denotes =
T7889 10521-10527 CD denotes 0.0425
T7900 10527-10528 -RRB- denotes )
T7901 10529-10530 -LRB- denotes (
T7902 10530-10535 NN denotes Table
T7903 10536-10537 CD denotes 2
T7904 10537-10538 -RRB- denotes )
T7905 10538-10539 . denotes .
T7906 10539-10650 sentence denotes Therefore, the obesity QTL in the HG2M unique region (Region IV) is profoundly impacted by the presence of hg.
T7907 10540-10549 RB denotes Therefore
T7909 10549-10551 , denotes ,
T7910 10551-10554 DT denotes the
T7912 10555-10562 NN denotes obesity
T7911 10563-10566 NN denotes QTL
T7913 10567-10569 IN denotes in
T7914 10570-10573 DT denotes the
T7916 10574-10578 NN denotes HG2M
T7917 10579-10585 JJ denotes unique
T7915 10586-10592 NN denotes region
T7918 10593-10594 -LRB- denotes (
T7919 10594-10600 NN denotes Region
T7920 10601-10603 CD denotes IV
T7921 10603-10604 -RRB- denotes )
T7922 10605-10607 VBZ denotes is
T7923 10608-10618 RB denotes profoundly
T7908 10619-10627 VBN denotes impacted
T7924 10628-10630 IN denotes by
T7925 10631-10634 DT denotes the
T7926 10635-10643 NN denotes presence
T7927 10644-10646 IN denotes of
T7928 10647-10649 NN denotes hg
T7929 10649-10650 . denotes .
T7930 10650-10687 sentence denotes Confirmation of QTL-hg interactions
T7931 10652-10664 NN denotes Confirmation
T7932 10665-10667 IN denotes of
T7933 10668-10671 NN denotes QTL
T7935 10671-10672 HYPH denotes -
T7934 10672-10674 NN denotes hg
T7936 10675-10687 NNS denotes interactions
T7937 10687-10945 sentence denotes An important feature of our experimental design was the ability to test for interactions between QTL in each MMU2 donor region and genotype at the HG locus, since identical donor regions were introgressed on two genetic backgrounds, B6 (+/+) and HG (hg/hg).
T7938 10688-10690 DT denotes An
T7940 10691-10700 JJ denotes important
T7939 10701-10708 NN denotes feature
T7942 10709-10711 IN denotes of
T7943 10712-10715 PRP$ denotes our
T7945 10716-10728 JJ denotes experimental
T7944 10729-10735 NN denotes design
T7941 10736-10739 VBD denotes was
T7946 10740-10743 DT denotes the
T7947 10744-10751 NN denotes ability
T7948 10752-10754 TO denotes to
T7949 10755-10759 VB denotes test
T7950 10760-10763 IN denotes for
T7951 10764-10776 NNS denotes interactions
T7952 10777-10784 IN denotes between
T7953 10785-10788 NN denotes QTL
T7954 10789-10791 IN denotes in
T7955 10792-10796 DT denotes each
T7957 10797-10801 NN denotes MMU2
T7958 10802-10807 NN denotes donor
T7956 10808-10814 NN denotes region
T7959 10815-10818 CC denotes and
T7960 10819-10827 VB denotes genotype
T7961 10828-10830 IN denotes at
T7962 10831-10834 DT denotes the
T7964 10835-10837 NN denotes HG
T7963 10838-10843 NN denotes locus
T7965 10843-10845 , denotes ,
T7966 10845-10850 IN denotes since
T7968 10851-10860 JJ denotes identical
T7970 10861-10866 NN denotes donor
T7969 10867-10874 NNS denotes regions
T7971 10875-10879 VBD denotes were
T7967 10880-10892 VBN denotes introgressed
T7972 10893-10895 IN denotes on
T7973 10896-10899 CD denotes two
T7975 10900-10907 JJ denotes genetic
T7974 10908-10919 NNS denotes backgrounds
T7976 10919-10921 , denotes ,
T7977 10921-10923 NN denotes B6
T7978 10924-10925 -LRB- denotes (
T7980 10925-10926 SYM denotes +
T7981 10926-10927 HYPH denotes /
T7979 10927-10928 SYM denotes +
T7982 10928-10929 -RRB- denotes )
T7983 10930-10933 CC denotes and
T7984 10934-10936 NN denotes HG
T7985 10937-10938 -LRB- denotes (
T7987 10938-10940 NN denotes hg
T7988 10940-10941 HYPH denotes /
T7986 10941-10943 NN denotes hg
T7989 10943-10944 -RRB- denotes )
T7990 10944-10945 . denotes .
T7991 10945-11101 sentence denotes Significant interactions between donor region and HG genotype were viewed as strong evidence that hg modifier QTL reside within that unique genomic region.
T7992 10946-10957 JJ denotes Significant
T7993 10958-10970 NNS denotes interactions
T7995 10971-10978 IN denotes between
T7996 10979-10984 NN denotes donor
T7997 10985-10991 NN denotes region
T7998 10992-10995 CC denotes and
T7999 10996-10998 NN denotes HG
T8000 10999-11007 NN denotes genotype
T8001 11008-11012 VBD denotes were
T7994 11013-11019 VBN denotes viewed
T8002 11020-11022 IN denotes as
T8003 11023-11029 JJ denotes strong
T8004 11030-11038 NN denotes evidence
T8005 11039-11043 IN denotes that
T8007 11044-11046 NN denotes hg
T8009 11047-11055 NN denotes modifier
T8008 11056-11059 NN denotes QTL
T8006 11060-11066 VBP denotes reside
T8010 11067-11073 IN denotes within
T8011 11074-11078 DT denotes that
T8013 11079-11085 JJ denotes unique
T8014 11086-11093 JJ denotes genomic
T8012 11094-11100 NN denotes region
T8015 11100-11101 . denotes .
T8016 11101-11236 sentence denotes In the original linkage analysis the mode of gene action and peak location of Wg2 were dependent on the presence of hg [24] (Table 1).
T8017 11102-11104 IN denotes In
T8019 11105-11108 DT denotes the
T8021 11109-11117 JJ denotes original
T8022 11118-11125 NN denotes linkage
T8020 11126-11134 NN denotes analysis
T8023 11135-11138 DT denotes the
T8024 11139-11143 NN denotes mode
T8025 11144-11146 IN denotes of
T8026 11147-11151 NN denotes gene
T8027 11152-11158 NN denotes action
T8028 11159-11162 CC denotes and
T8029 11163-11167 JJ denotes peak
T8030 11168-11176 NN denotes location
T8031 11177-11179 IN denotes of
T8032 11180-11183 NN denotes Wg2
T8018 11184-11188 VBD denotes were
T8033 11189-11198 JJ denotes dependent
T8034 11199-11201 IN denotes on
T8035 11202-11205 DT denotes the
T8036 11206-11214 NN denotes presence
T8037 11215-11217 IN denotes of
T8038 11218-11220 NN denotes hg
T8039 11221-11222 -LRB- denotes [
T8040 11222-11224 CD denotes 24
T8041 11224-11225 -RRB- denotes ]
T8042 11226-11227 -LRB- denotes (
T8043 11227-11232 NN denotes Table
T8044 11233-11234 CD denotes 1
T8045 11234-11235 -RRB- denotes )
T8046 11235-11236 . denotes .
T8047 11236-11363 sentence denotes In the present study, only homozygous congenic mice were characterized, thus, the overdominant effects of Wg2 were not tested.
T8048 11237-11239 IN denotes In
T8050 11240-11243 DT denotes the
T8052 11244-11251 JJ denotes present
T8051 11252-11257 NN denotes study
T8053 11257-11259 , denotes ,
T8054 11259-11263 RB denotes only
T8056 11264-11274 JJ denotes homozygous
T8057 11275-11283 JJ denotes congenic
T8055 11284-11288 NNS denotes mice
T8059 11289-11293 VBD denotes were
T8058 11294-11307 VBN denotes characterized
T8060 11307-11309 , denotes ,
T8061 11309-11313 RB denotes thus
T8062 11313-11315 , denotes ,
T8063 11315-11318 DT denotes the
T8065 11319-11331 JJ denotes overdominant
T8064 11332-11339 NNS denotes effects
T8066 11340-11342 IN denotes of
T8067 11343-11346 NN denotes Wg2
T8068 11347-11351 VBD denotes were
T8069 11352-11355 RB denotes not
T8049 11356-11362 VBN denotes tested
T8070 11362-11363 . denotes .
T8071 11363-11604 sentence denotes However, since its original peak location differed dependent on background we hypothesized that Wg2 represents a set of linked QTL between 74.9 and 181.8 Mbp within the 2M and 2D donor regions (Region III–V), some of which interact with hg.
T8072 11364-11371 RB denotes However
T8074 11371-11373 , denotes ,
T8075 11373-11378 IN denotes since
T8077 11379-11382 PRP$ denotes its
T8079 11383-11391 JJ denotes original
T8080 11392-11396 NN denotes peak
T8078 11397-11405 NN denotes location
T8076 11406-11414 VBD denotes differed
T8081 11415-11424 RB denotes dependent
T8082 11425-11427 IN denotes on
T8083 11428-11438 NN denotes background
T8084 11439-11441 PRP denotes we
T8073 11442-11454 VBD denotes hypothesized
T8085 11455-11459 IN denotes that
T8087 11460-11463 NN denotes Wg2
T8086 11464-11474 VBZ denotes represents
T8088 11475-11476 DT denotes a
T8089 11477-11480 NN denotes set
T8090 11481-11483 IN denotes of
T8091 11484-11490 VBN denotes linked
T8092 11491-11494 NN denotes QTL
T8093 11495-11502 IN denotes between
T8094 11503-11507 CD denotes 74.9
T8096 11508-11511 CC denotes and
T8097 11512-11517 CD denotes 181.8
T8095 11518-11521 NN denotes Mbp
T8098 11522-11528 IN denotes within
T8099 11529-11532 DT denotes the
T8101 11533-11535 NN denotes 2M
T8102 11536-11539 CC denotes and
T8103 11540-11542 NN denotes 2D
T8104 11543-11548 NN denotes donor
T8100 11549-11556 NNS denotes regions
T8105 11557-11558 -LRB- denotes (
T8106 11558-11564 NN denotes Region
T8107 11565-11568 CD denotes III
T8108 11568-11569 SYM denotes –
T8109 11569-11570 CD denotes V
T8110 11570-11571 -RRB- denotes )
T8111 11571-11573 , denotes ,
T8112 11573-11577 DT denotes some
T8114 11578-11580 IN denotes of
T8115 11581-11586 WDT denotes which
T8113 11587-11595 VBP denotes interact
T8116 11596-11600 IN denotes with
T8117 11601-11603 NN denotes hg
T8118 11603-11604 . denotes .
T8119 11604-11722 sentence denotes Following this logic we expected one or both of these strains would exhibit donor region by HG genotype interactions.
T8120 11605-11614 VBG denotes Following
T8122 11615-11619 DT denotes this
T8123 11620-11625 NN denotes logic
T8124 11626-11628 PRP denotes we
T8121 11629-11637 VBD denotes expected
T8125 11638-11641 CD denotes one
T8127 11642-11644 CC denotes or
T8128 11645-11649 DT denotes both
T8129 11650-11652 IN denotes of
T8130 11653-11658 DT denotes these
T8131 11659-11666 NNS denotes strains
T8132 11667-11672 MD denotes would
T8126 11673-11680 VB denotes exhibit
T8133 11681-11686 NN denotes donor
T8134 11687-11693 NN denotes region
T8136 11694-11696 IN denotes by
T8137 11697-11699 NN denotes HG
T8138 11700-11708 NN denotes genotype
T8135 11709-11721 NNS denotes interactions
T8139 11721-11722 . denotes .
T8140 11722-11779 sentence denotes Unfortunately, we were unable to characterize HG2D mice.
T8141 11723-11736 RB denotes Unfortunately
T8143 11736-11738 , denotes ,
T8144 11738-11740 PRP denotes we
T8142 11741-11745 VBD denotes were
T8145 11746-11752 JJ denotes unable
T8146 11753-11755 TO denotes to
T8147 11756-11768 VB denotes characterize
T8148 11769-11773 NN denotes HG2D
T8149 11774-11778 NNS denotes mice
T8150 11778-11779 . denotes .
T8151 11779-11856 sentence denotes However, as noted above, strong sex-specific effects were seen in HG2M mice.
T8152 11780-11787 RB denotes However
T8154 11787-11789 , denotes ,
T8155 11789-11791 IN denotes as
T8156 11792-11797 VBN denotes noted
T8157 11798-11803 RB denotes above
T8158 11803-11805 , denotes ,
T8159 11805-11811 JJ denotes strong
T8161 11812-11815 NN denotes sex
T8163 11815-11816 HYPH denotes -
T8162 11816-11824 JJ denotes specific
T8160 11825-11832 NNS denotes effects
T8164 11833-11837 VBD denotes were
T8153 11838-11842 VBN denotes seen
T8165 11843-11845 IN denotes in
T8166 11846-11850 NN denotes HG2M
T8167 11851-11855 NNS denotes mice
T8168 11855-11856 . denotes .
T8169 11856-11993 sentence denotes Significant 2M donor region by HG genotype by sex three-way interactions for AI (P = 0.0004; Figure 4) and TF were identified (Table 3).
T8170 11857-11868 JJ denotes Significant
T8172 11869-11871 NN denotes 2M
T8174 11872-11877 NN denotes donor
T8173 11878-11884 NN denotes region
T8175 11885-11887 IN denotes by
T8176 11888-11890 NN denotes HG
T8177 11891-11899 NN denotes genotype
T8178 11900-11902 IN denotes by
T8179 11903-11906 NN denotes sex
T8180 11907-11912 CD denotes three
T8182 11912-11913 HYPH denotes -
T8181 11913-11916 NN denotes way
T8171 11917-11929 NNS denotes interactions
T8184 11930-11933 IN denotes for
T8185 11934-11936 NN denotes AI
T8186 11937-11938 -LRB- denotes (
T8188 11938-11939 NN denotes P
T8190 11940-11941 SYM denotes =
T8189 11942-11948 CD denotes 0.0004
T8191 11948-11949 : denotes ;
T8187 11950-11956 NN denotes Figure
T8192 11957-11958 CD denotes 4
T8193 11958-11959 -RRB- denotes )
T8194 11960-11963 CC denotes and
T8195 11964-11966 NN denotes TF
T8196 11967-11971 VBD denotes were
T8183 11972-11982 VBN denotes identified
T8197 11983-11984 -LRB- denotes (
T8198 11984-11989 NN denotes Table
T8199 11990-11991 CD denotes 3
T8200 11991-11992 -RRB- denotes )
T8201 11992-11993 . denotes .
T8202 11993-12154 sentence denotes The basis of these interactions was a decrease in HG2M female and an increase in HG2M male adiposity, with no differences in fat accumulation across B62M sexes.
T8203 11994-11997 DT denotes The
T8204 11998-12003 NN denotes basis
T8206 12004-12006 IN denotes of
T8207 12007-12012 DT denotes these
T8208 12013-12025 NNS denotes interactions
T8205 12026-12029 VBD denotes was
T8209 12030-12031 DT denotes a
T8210 12032-12040 NN denotes decrease
T8211 12041-12043 IN denotes in
T8212 12044-12048 NN denotes HG2M
T8213 12049-12055 NN denotes female
T8214 12056-12059 CC denotes and
T8215 12060-12062 DT denotes an
T8216 12063-12071 NN denotes increase
T8218 12072-12074 IN denotes in
T8219 12075-12079 NN denotes HG2M
T8220 12080-12084 JJ denotes male
T8217 12085-12094 NN denotes adiposity
T8221 12094-12096 , denotes ,
T8222 12096-12100 IN denotes with
T8223 12101-12103 DT denotes no
T8224 12104-12115 NNS denotes differences
T8225 12116-12118 IN denotes in
T8226 12119-12122 NN denotes fat
T8227 12123-12135 NN denotes accumulation
T8228 12136-12142 IN denotes across
T8229 12143-12147 NN denotes B62M
T8230 12148-12153 NNS denotes sexes
T8231 12153-12154 . denotes .
T8232 12154-12312 sentence denotes Significant 2PM donor region by HG genotype two-way and 2PM donor region by HG genotype by sex three-way interactions were also seen for TF and AI (Table 3).
T8233 12155-12166 JJ denotes Significant
T8235 12167-12170 NN denotes 2PM
T8237 12171-12176 NN denotes donor
T8236 12177-12183 NN denotes region
T8239 12184-12186 IN denotes by
T8240 12187-12189 NN denotes HG
T8241 12190-12198 NN denotes genotype
T8242 12199-12202 CD denotes two
T8243 12202-12203 HYPH denotes -
T8238 12203-12206 NN denotes way
T8244 12207-12210 CC denotes and
T8245 12211-12214 NN denotes 2PM
T8247 12215-12220 NN denotes donor
T8246 12221-12227 NN denotes region
T8249 12228-12230 IN denotes by
T8250 12231-12233 NN denotes HG
T8251 12234-12242 NN denotes genotype
T8252 12243-12245 IN denotes by
T8253 12246-12249 NN denotes sex
T8254 12250-12255 CD denotes three
T8255 12255-12256 HYPH denotes -
T8248 12256-12259 NN denotes way
T8234 12260-12272 NNS denotes interactions
T8257 12273-12277 VBD denotes were
T8258 12278-12282 RB denotes also
T8256 12283-12287 VBN denotes seen
T8259 12288-12291 IN denotes for
T8260 12292-12294 NN denotes TF
T8261 12295-12298 CC denotes and
T8262 12299-12301 NN denotes AI
T8263 12302-12303 -LRB- denotes (
T8264 12303-12308 NN denotes Table
T8265 12309-12310 CD denotes 3
T8266 12310-12311 -RRB- denotes )
T8267 12311-12312 . denotes .
T8268 12312-12501 sentence denotes In addition, significant 2P donor region × HG genotype interactions were observed for all traits listed, although some traits did reached significance at the critical P < 0.0071 (Table 3).
T8269 12313-12315 IN denotes In
T8271 12316-12324 NN denotes addition
T8272 12324-12326 , denotes ,
T8273 12326-12337 JJ denotes significant
T8275 12338-12340 NN denotes 2P
T8277 12341-12346 NN denotes donor
T8276 12347-12353 NN denotes region
T8278 12354-12355 SYM denotes ×
T8280 12356-12358 NN denotes HG
T8279 12359-12367 NN denotes genotype
T8274 12368-12380 NNS denotes interactions
T8281 12381-12385 VBD denotes were
T8270 12386-12394 VBN denotes observed
T8282 12395-12398 IN denotes for
T8283 12399-12402 DT denotes all
T8284 12403-12409 NNS denotes traits
T8285 12410-12416 VBN denotes listed
T8286 12416-12418 , denotes ,
T8287 12418-12426 IN denotes although
T8289 12427-12431 DT denotes some
T8290 12432-12438 NNS denotes traits
T8291 12439-12442 VBD denotes did
T8288 12443-12450 VBN denotes reached
T8292 12451-12463 NN denotes significance
T8293 12464-12466 IN denotes at
T8294 12467-12470 DT denotes the
T8296 12471-12479 JJ denotes critical
T8297 12480-12481 NN denotes P
T8298 12482-12483 SYM denotes <
T8295 12484-12490 CD denotes 0.0071
T8299 12491-12492 -LRB- denotes (
T8300 12492-12497 NN denotes Table
T8301 12498-12499 CD denotes 3
T8302 12499-12500 -RRB- denotes )
T8303 12500-12501 . denotes .
T8304 12501-12624 sentence denotes The basis for each interaction was a decrease in phenotype in HG2P compared to HGC and no difference between B62P and B6C.
T8305 12502-12505 DT denotes The
T8306 12506-12511 NN denotes basis
T8308 12512-12515 IN denotes for
T8309 12516-12520 DT denotes each
T8310 12521-12532 NN denotes interaction
T8307 12533-12536 VBD denotes was
T8311 12537-12538 DT denotes a
T8312 12539-12547 NN denotes decrease
T8313 12548-12550 IN denotes in
T8314 12551-12560 NN denotes phenotype
T8315 12561-12563 IN denotes in
T8316 12564-12568 NN denotes HG2P
T8317 12569-12577 VBN denotes compared
T8318 12578-12580 IN denotes to
T8319 12581-12584 NN denotes HGC
T8320 12585-12588 CC denotes and
T8321 12589-12591 DT denotes no
T8322 12592-12602 NN denotes difference
T8323 12603-12610 IN denotes between
T8324 12611-12615 NN denotes B62P
T8325 12616-12619 CC denotes and
T8326 12620-12623 NN denotes B6C
T8327 12623-12624 . denotes .
T8328 12624-12705 sentence denotes Together these data confirm that MMU2 QTL modify the effects of the hg deletion.
T8329 12625-12633 RB denotes Together
T8331 12634-12639 DT denotes these
T8332 12640-12644 NNS denotes data
T8330 12645-12652 VBP denotes confirm
T8333 12653-12657 IN denotes that
T8335 12658-12662 NN denotes MMU2
T8336 12663-12666 NN denotes QTL
T8334 12667-12673 VBP denotes modify
T8337 12674-12677 DT denotes the
T8338 12678-12685 NNS denotes effects
T8339 12686-12688 IN denotes of
T8340 12689-12692 DT denotes the
T8342 12693-12695 NN denotes hg
T8341 12696-12704 NN denotes deletion
T8343 12704-12705 . denotes .
T11091 12707-12712 NN denotes Speed
T11092 12713-12721 JJ denotes congenic
T11093 12722-12729 NNS denotes strains
T11094 12730-12733 IN denotes for
T11095 12734-12737 NN denotes QTL
T11096 12738-12740 IN denotes on
T11097 12741-12744 NN denotes MMU
T11098 12744-12745 CD denotes 1
T11099 12745-12747 , denotes ,
T11100 12747-12748 CD denotes 8
T11101 12748-12750 , denotes ,
T11102 12750-12751 CD denotes 9
T11103 12751-12753 , denotes ,
T11104 12753-12755 CD denotes 11
T11105 12756-12759 CC denotes and
T11106 12760-12762 CD denotes 17
T11107 12762-12767 sentence denotes HG1
T11108 12764-12767 NN denotes HG1
T11109 12767-12944 sentence denotes Q1Ucd1 affecting G26 was the least significant of any QTL identified in the original intercross and only reached a suggestive level of significance (LOD = 2.46, P < 0.05) [26].
T11110 12768-12774 NN denotes Q1Ucd1
T11112 12775-12784 VBG denotes affecting
T11113 12785-12788 NN denotes G26
T11111 12789-12792 VBD denotes was
T11114 12793-12796 DT denotes the
T11116 12797-12802 JJS denotes least
T11115 12803-12814 JJ denotes significant
T11117 12815-12817 IN denotes of
T11118 12818-12821 DT denotes any
T11119 12822-12825 NN denotes QTL
T11120 12826-12836 VBN denotes identified
T11121 12837-12839 IN denotes in
T11122 12840-12843 DT denotes the
T11124 12844-12852 JJ denotes original
T11123 12853-12863 NN denotes intercross
T11125 12864-12867 CC denotes and
T11126 12868-12872 RB denotes only
T11127 12873-12880 VBD denotes reached
T11128 12881-12882 DT denotes a
T11130 12883-12893 JJ denotes suggestive
T11129 12894-12899 NN denotes level
T11131 12900-12902 IN denotes of
T11132 12903-12915 NN denotes significance
T11133 12916-12917 -LRB- denotes (
T11135 12917-12920 NN denotes LOD
T11137 12921-12922 SYM denotes =
T11136 12923-12927 CD denotes 2.46
T11138 12927-12929 , denotes ,
T11139 12929-12930 NN denotes P
T11140 12931-12932 SYM denotes <
T11134 12933-12937 CD denotes 0.05
T11141 12937-12938 -RRB- denotes )
T11142 12939-12940 -LRB- denotes [
T11143 12940-12942 CD denotes 26
T11144 12942-12943 -RRB- denotes ]
T11145 12943-12944 . denotes .
T11146 12944-13023 sentence denotes In accordance, HG1 mice had small differences in all growth and length traits.
T11147 12945-12947 IN denotes In
T11149 12948-12958 NN denotes accordance
T11150 12958-12960 , denotes ,
T11151 12960-12963 NN denotes HG1
T11152 12964-12968 NNS denotes mice
T11148 12969-12972 VBD denotes had
T11153 12973-12978 JJ denotes small
T11154 12979-12990 NNS denotes differences
T11155 12991-12993 IN denotes in
T11156 12994-12997 DT denotes all
T11158 12998-13004 NN denotes growth
T11159 13005-13008 CC denotes and
T11160 13009-13015 NN denotes length
T11157 13016-13022 NNS denotes traits
T11161 13022-13023 . denotes .
T11162 13023-13136 sentence denotes NA in both sexes and 2WK, 3WK, 6WK and tail length in females was significant at a critical P < 0.005 (Table 4).
T11163 13024-13026 NN denotes NA
T11165 13027-13029 IN denotes in
T11166 13030-13034 CC denotes both
T11167 13035-13040 NNS denotes sexes
T11168 13041-13044 CC denotes and
T11169 13045-13048 NN denotes 2WK
T11171 13048-13050 , denotes ,
T11172 13050-13053 NN denotes 3WK
T11173 13053-13055 , denotes ,
T11170 13055-13058 NN denotes 6WK
T11174 13059-13062 CC denotes and
T11175 13063-13067 NN denotes tail
T11176 13068-13074 NN denotes length
T11177 13075-13077 IN denotes in
T11178 13078-13085 NNS denotes females
T11164 13086-13089 VBD denotes was
T11179 13090-13101 JJ denotes significant
T11180 13102-13104 IN denotes at
T11181 13105-13106 DT denotes a
T11183 13107-13115 JJ denotes critical
T11184 13116-13117 NN denotes P
T11185 13118-13119 SYM denotes <
T11182 13120-13125 CD denotes 0.005
T11186 13126-13127 -LRB- denotes (
T11187 13127-13132 NN denotes Table
T11188 13133-13134 CD denotes 4
T11189 13134-13135 -RRB- denotes )
T11190 13135-13136 . denotes .
T11191 13136-13219 sentence denotes The only difference in adiposity was a significant decrease in male MFP (Table 5).
T11192 13137-13140 DT denotes The
T11194 13141-13145 JJ denotes only
T11193 13146-13156 NN denotes difference
T11196 13157-13159 IN denotes in
T11197 13160-13169 NN denotes adiposity
T11195 13170-13173 VBD denotes was
T11198 13174-13175 DT denotes a
T11200 13176-13187 JJ denotes significant
T11199 13188-13196 NN denotes decrease
T11201 13197-13199 IN denotes in
T11202 13200-13204 JJ denotes male
T11203 13205-13208 NN denotes MFP
T11204 13209-13210 -LRB- denotes (
T11205 13210-13215 NN denotes Table
T11206 13216-13217 CD denotes 5
T11207 13217-13218 -RRB- denotes )
T11208 13218-13219 . denotes .
T11209 13219-13400 sentence denotes The successful capture and confirmation of the small effect Q1Ucd1-w26 QTL adds support to pursuing QTL identified at suggestive levels of statistical confidence from genome scans.
T11210 13220-13223 DT denotes The
T11212 13224-13234 JJ denotes successful
T11211 13235-13242 NN denotes capture
T11214 13243-13246 CC denotes and
T11215 13247-13259 NN denotes confirmation
T11216 13260-13262 IN denotes of
T11217 13263-13266 DT denotes the
T11219 13267-13272 JJ denotes small
T11220 13273-13279 NN denotes effect
T11221 13280-13286 NN denotes Q1Ucd1
T11223 13286-13287 HYPH denotes -
T11222 13287-13290 NN denotes w26
T11218 13291-13294 NN denotes QTL
T11213 13295-13299 VBZ denotes adds
T11224 13300-13307 NN denotes support
T11225 13308-13310 IN denotes to
T11226 13311-13319 VBG denotes pursuing
T11227 13320-13323 NN denotes QTL
T11228 13324-13334 VBN denotes identified
T11229 13335-13337 IN denotes at
T11230 13338-13348 JJ denotes suggestive
T11231 13349-13355 NNS denotes levels
T11232 13356-13358 IN denotes of
T11233 13359-13370 JJ denotes statistical
T11234 13371-13381 NN denotes confidence
T11235 13382-13386 IN denotes from
T11236 13387-13393 NN denotes genome
T11237 13394-13399 NNS denotes scans
T11238 13399-13400 . denotes .
T11239 13400-13405 sentence denotes HG8
T11240 13402-13405 NN denotes HG8
T11241 13405-13475 sentence denotes Markers on MMU8 were linked with G29 in the original intercross [24].
T11242 13406-13413 NNS denotes Markers
T11244 13414-13416 IN denotes on
T11245 13417-13421 NN denotes MMU8
T11246 13422-13426 VBD denotes were
T11243 13427-13433 VBN denotes linked
T11247 13434-13438 IN denotes with
T11248 13439-13442 NN denotes G29
T11249 13443-13445 IN denotes in
T11250 13446-13449 DT denotes the
T11252 13450-13458 JJ denotes original
T11251 13459-13469 NN denotes intercross
T11253 13470-13471 -LRB- denotes [
T11254 13471-13473 CD denotes 24
T11255 13473-13474 -RRB- denotes ]
T11256 13474-13475 . denotes .
T11257 13475-13548 sentence denotes This QTL was small, only accounting for 4.3% of the phenotypic variance.
T11258 13476-13480 DT denotes This
T11259 13481-13484 NN denotes QTL
T11260 13485-13488 VBD denotes was
T11261 13489-13494 JJ denotes small
T11262 13494-13496 , denotes ,
T11263 13496-13500 RB denotes only
T11264 13501-13511 VBG denotes accounting
T11265 13512-13515 IN denotes for
T11266 13516-13519 CD denotes 4.3
T11267 13519-13520 NN denotes %
T11268 13521-13523 IN denotes of
T11269 13524-13527 DT denotes the
T11271 13528-13538 JJ denotes phenotypic
T11270 13539-13547 NN denotes variance
T11272 13547-13548 . denotes .
T11273 13548-13680 sentence denotes Interestingly, in HG8 mice no differences in growth were detected; however, they were significantly leaner than controls (Table 5).
T11274 13549-13562 RB denotes Interestingly
T11276 13562-13564 , denotes ,
T11277 13564-13566 IN denotes in
T11278 13567-13570 NN denotes HG8
T11279 13571-13575 NNS denotes mice
T11280 13576-13578 DT denotes no
T11281 13579-13590 NNS denotes differences
T11282 13591-13593 IN denotes in
T11283 13594-13600 NN denotes growth
T11284 13601-13605 VBD denotes were
T11275 13606-13614 VBN denotes detected
T11286 13614-13615 : denotes ;
T11287 13616-13623 RB denotes however
T11288 13623-13625 , denotes ,
T11289 13625-13629 PRP denotes they
T11285 13630-13634 VBD denotes were
T11290 13635-13648 RB denotes significantly
T11291 13649-13655 JJR denotes leaner
T11292 13656-13660 IN denotes than
T11293 13661-13669 NNS denotes controls
T11294 13670-13671 -LRB- denotes (
T11295 13671-13676 NN denotes Table
T11296 13677-13678 CD denotes 5
T11297 13678-13679 -RRB- denotes )
T11298 13679-13680 . denotes .
T11299 13680-13808 sentence denotes In males a general decrease in fat pad mass, TF and AI was detected; however, only MFP was significant at a critical P < 0.005.
T11300 13681-13683 IN denotes In
T11302 13684-13689 NNS denotes males
T11303 13690-13691 DT denotes a
T11305 13692-13699 JJ denotes general
T11304 13700-13708 NN denotes decrease
T11307 13709-13711 IN denotes in
T11308 13712-13715 NN denotes fat
T11309 13716-13719 NN denotes pad
T11310 13720-13724 NN denotes mass
T11311 13724-13726 , denotes ,
T11312 13726-13728 NN denotes TF
T11313 13729-13732 CC denotes and
T11314 13733-13735 NN denotes AI
T11315 13736-13739 VBD denotes was
T11306 13740-13748 VBN denotes detected
T11316 13748-13749 : denotes ;
T11317 13750-13757 RB denotes however
T11318 13757-13759 , denotes ,
T11319 13759-13763 RB denotes only
T11320 13764-13767 NN denotes MFP
T11301 13768-13771 VBD denotes was
T11321 13772-13783 JJ denotes significant
T11322 13784-13786 IN denotes at
T11323 13787-13788 DT denotes a
T11325 13789-13797 JJ denotes critical
T11326 13798-13799 NN denotes P
T11327 13800-13801 SYM denotes <
T11324 13802-13807 CD denotes 0.005
T11328 13807-13808 . denotes .
T11329 13808-13864 sentence denotes Male AI was nearly significant at a nominal P = 0.0082.
T11330 13809-13813 JJ denotes Male
T11331 13814-13816 NN denotes AI
T11332 13817-13820 VBD denotes was
T11333 13821-13827 RB denotes nearly
T11334 13828-13839 JJ denotes significant
T11335 13840-13842 IN denotes at
T11336 13843-13844 DT denotes a
T11338 13845-13852 JJ denotes nominal
T11339 13853-13854 NN denotes P
T11340 13855-13856 SYM denotes =
T11337 13857-13863 CD denotes 0.0082
T11341 13863-13864 . denotes .
T11342 13864-13976 sentence denotes Larger decreases in fat mass were seen in HG8 females, with significant decreases detected for GFP, MFP and AI.
T11343 13865-13871 JJR denotes Larger
T11344 13872-13881 NNS denotes decreases
T11346 13882-13884 IN denotes in
T11347 13885-13888 NN denotes fat
T11348 13889-13893 NN denotes mass
T11349 13894-13898 VBD denotes were
T11345 13899-13903 VBN denotes seen
T11350 13904-13906 IN denotes in
T11351 13907-13910 NN denotes HG8
T11352 13911-13918 NNS denotes females
T11353 13918-13920 , denotes ,
T11354 13920-13924 IN denotes with
T11356 13925-13936 JJ denotes significant
T11357 13937-13946 NNS denotes decreases
T11355 13947-13955 VBN denotes detected
T11358 13956-13959 IN denotes for
T11359 13960-13963 NN denotes GFP
T11360 13963-13965 , denotes ,
T11361 13965-13968 NN denotes MFP
T11362 13969-13972 CC denotes and
T11363 13973-13975 NN denotes AI
T11364 13975-13976 . denotes .
T11365 13976-14083 sentence denotes Additionally, RFP and TF were nearly significant with nominal P values of 0.0208 and 0.0153, respectively.
T11366 13977-13989 RB denotes Additionally
T11368 13989-13991 , denotes ,
T11369 13991-13994 NN denotes RFP
T11370 13995-13998 CC denotes and
T11371 13999-14001 NN denotes TF
T11367 14002-14006 VBD denotes were
T11372 14007-14013 RB denotes nearly
T11373 14014-14025 JJ denotes significant
T11374 14026-14030 IN denotes with
T11375 14031-14038 JJ denotes nominal
T11377 14039-14040 NN denotes P
T11376 14041-14047 NNS denotes values
T11378 14048-14050 IN denotes of
T11379 14051-14057 CD denotes 0.0208
T11380 14058-14061 CC denotes and
T11381 14062-14068 CD denotes 0.0153
T11382 14068-14070 , denotes ,
T11383 14070-14082 RB denotes respectively
T11384 14082-14083 . denotes .
T11385 14083-14180 sentence denotes HG8 mice represent a lean congenic model in which CAST alleles protect against fat accumulation.
T11386 14084-14087 NN denotes HG8
T11387 14088-14092 NNS denotes mice
T11388 14093-14102 VBP denotes represent
T11389 14103-14104 DT denotes a
T11391 14105-14109 JJ denotes lean
T11392 14110-14118 JJ denotes congenic
T11390 14119-14124 NN denotes model
T11393 14125-14127 IN denotes in
T11395 14128-14133 WDT denotes which
T11396 14134-14138 NN denotes CAST
T11397 14139-14146 NNS denotes alleles
T11394 14147-14154 VBP denotes protect
T11398 14155-14162 IN denotes against
T11399 14163-14166 NN denotes fat
T11400 14167-14179 NN denotes accumulation
T11401 14179-14180 . denotes .
T11402 14180-14185 sentence denotes HG9
T11403 14182-14185 NN denotes HG9
T11404 14185-14341 sentence denotes CAST alleles in the proximal region of MMU9 were previously found to be linked with an increase in body fat percentage and a decrease in femur length [24].
T11405 14186-14190 NN denotes CAST
T11406 14191-14198 NNS denotes alleles
T11408 14199-14201 IN denotes in
T11409 14202-14205 DT denotes the
T11411 14206-14214 JJ denotes proximal
T11410 14215-14221 NN denotes region
T11412 14222-14224 IN denotes of
T11413 14225-14229 NN denotes MMU9
T11414 14230-14234 VBD denotes were
T11415 14235-14245 RB denotes previously
T11407 14246-14251 VBN denotes found
T11416 14252-14254 TO denotes to
T11418 14255-14257 VB denotes be
T11417 14258-14264 VBN denotes linked
T11419 14265-14269 IN denotes with
T11420 14270-14272 DT denotes an
T11421 14273-14281 NN denotes increase
T11422 14282-14284 IN denotes in
T11423 14285-14289 NN denotes body
T11424 14290-14293 NN denotes fat
T11425 14294-14304 NN denotes percentage
T11426 14305-14308 CC denotes and
T11427 14309-14310 DT denotes a
T11428 14311-14319 NN denotes decrease
T11429 14320-14322 IN denotes in
T11430 14323-14328 NN denotes femur
T11431 14329-14335 NN denotes length
T11432 14336-14337 -LRB- denotes [
T11433 14337-14339 CD denotes 24
T11434 14339-14340 -RRB- denotes ]
T11435 14340-14341 . denotes .
T11436 14341-14499 sentence denotes The effects appeared to be the result of two linked QTL, Carfhg2 at 10 cM and Feml2 at 20 cM, instead of one pleiotropically impacting both traits (Table 1).
T11437 14342-14345 DT denotes The
T11438 14346-14353 NNS denotes effects
T11439 14354-14362 VBD denotes appeared
T11440 14363-14365 TO denotes to
T11441 14366-14368 VB denotes be
T11442 14369-14372 DT denotes the
T11443 14373-14379 NN denotes result
T11444 14380-14382 IN denotes of
T11445 14383-14386 CD denotes two
T11447 14387-14393 VBN denotes linked
T11446 14394-14397 NN denotes QTL
T11448 14397-14399 , denotes ,
T11449 14399-14406 NN denotes Carfhg2
T11450 14407-14409 IN denotes at
T11451 14410-14412 CD denotes 10
T11452 14413-14415 NN denotes cM
T11453 14416-14419 CC denotes and
T11454 14420-14425 NN denotes Feml2
T11455 14426-14428 IN denotes at
T11456 14429-14431 CD denotes 20
T11457 14432-14434 NN denotes cM
T11458 14434-14436 , denotes ,
T11459 14436-14443 IN denotes instead
T11460 14444-14446 IN denotes of
T11461 14447-14450 CD denotes one
T11462 14451-14466 RB denotes pleiotropically
T11463 14467-14476 VBG denotes impacting
T11464 14477-14481 DT denotes both
T11465 14482-14488 NNS denotes traits
T11466 14489-14490 -LRB- denotes (
T11467 14490-14495 NN denotes Table
T11468 14496-14497 CD denotes 1
T11469 14497-14498 -RRB- denotes )
T11470 14498-14499 . denotes .
T11471 14499-14612 sentence denotes In support of this, the increase in fat was dependent on hg; however, differences in femur length were not [24].
T11472 14500-14502 IN denotes In
T11474 14503-14510 NN denotes support
T11475 14511-14513 IN denotes of
T11476 14514-14518 DT denotes this
T11477 14518-14520 , denotes ,
T11478 14520-14523 DT denotes the
T11479 14524-14532 NN denotes increase
T11480 14533-14535 IN denotes in
T11481 14536-14539 NN denotes fat
T11473 14540-14543 VBD denotes was
T11483 14544-14553 JJ denotes dependent
T11484 14554-14556 IN denotes on
T11485 14557-14559 NN denotes hg
T11486 14559-14560 : denotes ;
T11487 14561-14568 RB denotes however
T11488 14568-14570 , denotes ,
T11489 14570-14581 NNS denotes differences
T11490 14582-14584 IN denotes in
T11491 14585-14590 NN denotes femur
T11492 14591-14597 NN denotes length
T11482 14598-14602 VBD denotes were
T11493 14603-14606 RB denotes not
T11494 14607-14608 -LRB- denotes [
T11495 14608-14610 CD denotes 24
T11496 14610-14611 -RRB- denotes ]
T11497 14611-14612 . denotes .
T11498 14612-14771 sentence denotes In confirmation of Carfhg2 all measures of adiposity in HG9 mice were increased relative to control mice; except MFP in both sexes and BMI in males (Table 5).
T11499 14613-14615 IN denotes In
T11501 14616-14628 NN denotes confirmation
T11502 14629-14631 IN denotes of
T11503 14632-14639 NN denotes Carfhg2
T11504 14640-14643 DT denotes all
T11505 14644-14652 NNS denotes measures
T11506 14653-14655 IN denotes of
T11507 14656-14665 NN denotes adiposity
T11508 14666-14668 IN denotes in
T11509 14669-14672 NN denotes HG9
T11510 14673-14677 NNS denotes mice
T11511 14678-14682 VBD denotes were
T11500 14683-14692 VBN denotes increased
T11512 14693-14701 JJ denotes relative
T11513 14702-14704 IN denotes to
T11514 14705-14712 NN denotes control
T11515 14713-14717 NNS denotes mice
T11516 14717-14718 : denotes ;
T11517 14719-14725 IN denotes except
T11518 14726-14729 NN denotes MFP
T11519 14730-14732 IN denotes in
T11520 14733-14737 CC denotes both
T11521 14738-14743 NNS denotes sexes
T11522 14744-14747 CC denotes and
T11523 14748-14751 NN denotes BMI
T11524 14752-14754 IN denotes in
T11525 14755-14760 NNS denotes males
T11526 14761-14762 -LRB- denotes (
T11527 14762-14767 NN denotes Table
T11528 14768-14769 CD denotes 5
T11529 14769-14770 -RRB- denotes )
T11530 14770-14771 . denotes .
T11531 14771-14865 sentence denotes In males, GFP, RFP, FFP and AI were increased by 29.0%, 51.2%, 42.9% and 30.0%, respectively.
T11532 14772-14774 IN denotes In
T11534 14775-14780 NNS denotes males
T11535 14780-14782 , denotes ,
T11536 14782-14785 NN denotes GFP
T11537 14785-14787 , denotes ,
T11538 14787-14790 NN denotes RFP
T11539 14790-14792 , denotes ,
T11540 14792-14795 NN denotes FFP
T11541 14796-14799 CC denotes and
T11542 14800-14802 NN denotes AI
T11543 14803-14807 VBD denotes were
T11533 14808-14817 VBN denotes increased
T11544 14818-14820 IN denotes by
T11545 14821-14825 CD denotes 29.0
T11546 14825-14826 NN denotes %
T11547 14826-14828 , denotes ,
T11548 14828-14832 CD denotes 51.2
T11549 14832-14833 NN denotes %
T11550 14833-14835 , denotes ,
T11551 14835-14839 CD denotes 42.9
T11552 14839-14840 NN denotes %
T11553 14841-14844 CC denotes and
T11554 14845-14849 CD denotes 30.0
T11555 14849-14850 NN denotes %
T11556 14850-14852 , denotes ,
T11557 14852-14864 RB denotes respectively
T11558 14864-14865 . denotes .
T11559 14865-14910 sentence denotes In females these increases were much larger.
T11560 14866-14868 IN denotes In
T11562 14869-14876 NNS denotes females
T11563 14877-14882 DT denotes these
T11564 14883-14892 NNS denotes increases
T11561 14893-14897 VBD denotes were
T11565 14898-14902 RB denotes much
T11566 14903-14909 JJR denotes larger
T11567 14909-14910 . denotes .
T11568 14910-15006 sentence denotes The same measurements were increased by 68.8%, 99.4%, 69.7% and 57.3%, relative to HGC females.
T11569 14911-14914 DT denotes The
T11571 14915-14919 JJ denotes same
T11570 14920-14932 NNS denotes measurements
T11573 14933-14937 VBD denotes were
T11572 14938-14947 VBN denotes increased
T11574 14948-14950 IN denotes by
T11575 14951-14955 CD denotes 68.8
T11576 14955-14956 NN denotes %
T11577 14956-14958 , denotes ,
T11578 14958-14962 CD denotes 99.4
T11579 14962-14963 NN denotes %
T11580 14963-14965 , denotes ,
T11581 14965-14969 CD denotes 69.7
T11582 14969-14970 NN denotes %
T11583 14971-14974 CC denotes and
T11584 14975-14979 CD denotes 57.3
T11585 14979-14980 NN denotes %
T11586 14980-14982 , denotes ,
T11587 14982-14990 JJ denotes relative
T11588 14991-14993 IN denotes to
T11589 14994-14997 NN denotes HGC
T11590 14998-15005 NNS denotes females
T11591 15005-15006 . denotes .
T11592 15006-15088 sentence denotes A 2.9% and 3.6% reduction in male and female NA, respectively, was also detected.
T11593 15007-15008 DT denotes A
T11595 15009-15012 CD denotes 2.9
T11596 15012-15013 NN denotes %
T11597 15014-15017 CC denotes and
T11598 15018-15021 CD denotes 3.6
T11599 15021-15022 NN denotes %
T11594 15023-15032 NN denotes reduction
T11601 15033-15035 IN denotes in
T11602 15036-15040 JJ denotes male
T11604 15041-15044 CC denotes and
T11605 15045-15051 JJ denotes female
T11603 15052-15054 NN denotes NA
T11606 15054-15056 , denotes ,
T11607 15056-15068 RB denotes respectively
T11608 15068-15070 , denotes ,
T11609 15070-15073 VBD denotes was
T11610 15074-15078 RB denotes also
T11600 15079-15087 VBN denotes detected
T11611 15087-15088 . denotes .
T11612 15088-15269 sentence denotes This was expected since NA was previously found to be an excellent indicator of femur length (R2 = 0.88) in HG mice [27] and as noted above this region contains the Feml2 QTL [24].
T11613 15089-15093 DT denotes This
T11615 15094-15097 VBD denotes was
T11614 15098-15106 VBN denotes expected
T11616 15107-15112 IN denotes since
T11618 15113-15115 NN denotes NA
T11619 15116-15119 VBD denotes was
T11620 15120-15130 RB denotes previously
T11617 15131-15136 VBN denotes found
T11621 15137-15139 TO denotes to
T11622 15140-15142 VB denotes be
T11623 15143-15145 DT denotes an
T11625 15146-15155 JJ denotes excellent
T11624 15156-15165 NN denotes indicator
T11626 15166-15168 IN denotes of
T11627 15169-15174 NN denotes femur
T11628 15175-15181 NN denotes length
T11629 15182-15183 -LRB- denotes (
T11631 15183-15185 NN denotes R2
T11632 15186-15187 SYM denotes =
T11630 15188-15192 CD denotes 0.88
T11633 15192-15193 -RRB- denotes )
T11634 15194-15196 IN denotes in
T11635 15197-15199 NN denotes HG
T11636 15200-15204 NNS denotes mice
T11637 15205-15206 -LRB- denotes [
T11638 15206-15208 CD denotes 27
T11639 15208-15209 -RRB- denotes ]
T11640 15210-15213 CC denotes and
T11641 15214-15216 IN denotes as
T11642 15217-15222 VBN denotes noted
T11644 15223-15228 RB denotes above
T11645 15229-15233 DT denotes this
T11646 15234-15240 NN denotes region
T11643 15241-15249 VBZ denotes contains
T11647 15250-15253 DT denotes the
T11649 15254-15259 NN denotes Feml2
T11648 15260-15263 NN denotes QTL
T11650 15264-15265 -LRB- denotes [
T11651 15265-15267 CD denotes 24
T11652 15267-15268 -RRB- denotes ]
T11653 15268-15269 . denotes .
T11654 15269-15436 sentence denotes These data confirm the effects of Carfhg2 on adiposity and Feml2 on length and indicate the isolated effects of Carfhg2 are more significant than originally observed.
T11655 15270-15275 DT denotes These
T11656 15276-15280 NNS denotes data
T11657 15281-15288 VBP denotes confirm
T11658 15289-15292 DT denotes the
T11659 15293-15300 NNS denotes effects
T11660 15301-15303 IN denotes of
T11661 15304-15311 NN denotes Carfhg2
T11662 15312-15314 IN denotes on
T11663 15315-15324 NN denotes adiposity
T11664 15325-15328 CC denotes and
T11665 15329-15334 NN denotes Feml2
T11666 15335-15337 IN denotes on
T11667 15338-15344 NN denotes length
T11668 15345-15348 CC denotes and
T11669 15349-15357 VBP denotes indicate
T11670 15358-15361 DT denotes the
T11672 15362-15370 VBN denotes isolated
T11671 15371-15378 NNS denotes effects
T11674 15379-15381 IN denotes of
T11675 15382-15389 NN denotes Carfhg2
T11673 15390-15393 VBP denotes are
T11676 15394-15398 RBR denotes more
T11677 15399-15410 JJ denotes significant
T11678 15411-15415 IN denotes than
T11680 15416-15426 RB denotes originally
T11679 15427-15435 VBN denotes observed
T11681 15435-15436 . denotes .
T11682 15436-15442 sentence denotes HG11
T11683 15438-15442 NN denotes HG11
T11684 15442-15590 sentence denotes In the original intercross CAST alleles near 50 cM on MMU11 were linked with a reduction in G29, carcass ash (ASH) and carcass protein (PROT) [24].
T11685 15443-15445 IN denotes In
T11687 15446-15449 DT denotes the
T11689 15450-15458 JJ denotes original
T11688 15459-15469 NN denotes intercross
T11690 15470-15474 NN denotes CAST
T11691 15475-15482 NNS denotes alleles
T11692 15483-15487 IN denotes near
T11693 15488-15490 CD denotes 50
T11694 15491-15493 NN denotes cM
T11695 15494-15496 IN denotes on
T11696 15497-15502 NN denotes MMU11
T11697 15503-15507 VBD denotes were
T11686 15508-15514 VBN denotes linked
T11698 15515-15519 IN denotes with
T11699 15520-15521 DT denotes a
T11700 15522-15531 NN denotes reduction
T11701 15532-15534 IN denotes in
T11702 15535-15538 NN denotes G29
T11703 15538-15540 , denotes ,
T11704 15540-15547 NN denotes carcass
T11705 15548-15551 NN denotes ash
T11706 15552-15553 -LRB- denotes (
T11707 15553-15556 NN denotes ASH
T11708 15556-15557 -RRB- denotes )
T11709 15558-15561 CC denotes and
T11710 15562-15569 NN denotes carcass
T11711 15570-15577 NN denotes protein
T11712 15578-15579 -LRB- denotes (
T11713 15579-15583 NN denotes PROT
T11714 15583-15584 -RRB- denotes )
T11715 15585-15586 -LRB- denotes [
T11716 15586-15588 CD denotes 24
T11717 15588-15589 -RRB- denotes ]
T11718 15589-15590 . denotes .
T11719 15590-15709 sentence denotes Therefore, we measured each carcass component using chemical compositional analysis in the HGC, HG11 and HG17 strains.
T11720 15591-15600 RB denotes Therefore
T11722 15600-15602 , denotes ,
T11723 15602-15604 PRP denotes we
T11721 15605-15613 VBD denotes measured
T11724 15614-15618 DT denotes each
T11726 15619-15626 NN denotes carcass
T11725 15627-15636 NN denotes component
T11727 15637-15642 VBG denotes using
T11728 15643-15651 JJ denotes chemical
T11730 15652-15665 JJ denotes compositional
T11729 15666-15674 NN denotes analysis
T11731 15675-15677 IN denotes in
T11732 15678-15681 DT denotes the
T11734 15682-15685 NN denotes HGC
T11735 15685-15687 , denotes ,
T11736 15687-15691 NN denotes HG11
T11737 15692-15695 CC denotes and
T11738 15696-15700 NN denotes HG17
T11733 15701-15708 NNS denotes strains
T11739 15708-15709 . denotes .
T11740 15709-15814 sentence denotes Originally, Carp2 was dependent on the presence of hg and no significant sex effects were detected [24].
T11741 15710-15720 RB denotes Originally
T11743 15720-15722 , denotes ,
T11744 15722-15727 NN denotes Carp2
T11742 15728-15731 VBD denotes was
T11745 15732-15741 JJ denotes dependent
T11746 15742-15744 IN denotes on
T11747 15745-15748 DT denotes the
T11748 15749-15757 NN denotes presence
T11749 15758-15760 IN denotes of
T11750 15761-15763 NN denotes hg
T11751 15764-15767 CC denotes and
T11752 15768-15770 DT denotes no
T11754 15771-15782 JJ denotes significant
T11755 15783-15786 NN denotes sex
T11753 15787-15794 NNS denotes effects
T11757 15795-15799 VBD denotes were
T11756 15800-15808 VBN denotes detected
T11758 15809-15810 -LRB- denotes [
T11759 15810-15812 CD denotes 24
T11760 15812-15813 -RRB- denotes ]
T11761 15813-15814 . denotes .
T11762 15814-15929 sentence denotes In contrast to those results, HG11 mice displayed significant differences in growth and obesity between the sexes.
T11763 15815-15817 IN denotes In
T11765 15818-15826 NN denotes contrast
T11766 15827-15829 IN denotes to
T11767 15830-15835 DT denotes those
T11768 15836-15843 NNS denotes results
T11769 15843-15845 , denotes ,
T11770 15845-15849 NN denotes HG11
T11771 15850-15854 NNS denotes mice
T11764 15855-15864 VBD denotes displayed
T11772 15865-15876 JJ denotes significant
T11773 15877-15888 NNS denotes differences
T11774 15889-15891 IN denotes in
T11775 15892-15898 NN denotes growth
T11776 15899-15902 CC denotes and
T11777 15903-15910 NN denotes obesity
T11778 15911-15918 IN denotes between
T11779 15919-15922 DT denotes the
T11780 15923-15928 NNS denotes sexes
T11781 15928-15929 . denotes .
T11782 15929-16040 sentence denotes In general, males demonstrated a 5% increase and females a 5% decrease in all growth-related traits (Table 4).
T11783 15930-15932 IN denotes In
T11785 15933-15940 JJ denotes general
T11786 15940-15942 , denotes ,
T11787 15942-15947 NNS denotes males
T11784 15948-15960 VBD denotes demonstrated
T11788 15961-15962 DT denotes a
T11790 15963-15964 CD denotes 5
T11791 15964-15965 NN denotes %
T11789 15966-15974 NN denotes increase
T11792 15975-15978 CC denotes and
T11793 15979-15986 NNS denotes females
T11795 15987-15988 DT denotes a
T11796 15989-15990 CD denotes 5
T11797 15990-15991 NN denotes %
T11794 15992-16000 NN denotes decrease
T11798 16001-16003 IN denotes in
T11799 16004-16007 DT denotes all
T11801 16008-16014 NN denotes growth
T11803 16014-16015 HYPH denotes -
T11802 16015-16022 VBN denotes related
T11800 16023-16029 NNS denotes traits
T11804 16030-16031 -LRB- denotes (
T11805 16031-16036 NN denotes Table
T11806 16037-16038 CD denotes 4
T11807 16038-16039 -RRB- denotes )
T11808 16039-16040 . denotes .
T11809 16040-16170 sentence denotes Most of these differences, however, were not significant at a critical P < 0.005, although almost all were at a nominal P < 0.05.
T11810 16041-16045 JJS denotes Most
T11812 16046-16048 IN denotes of
T11813 16049-16054 DT denotes these
T11814 16055-16066 NNS denotes differences
T11815 16066-16068 , denotes ,
T11816 16068-16075 RB denotes however
T11817 16075-16077 , denotes ,
T11811 16077-16081 VBD denotes were
T11818 16082-16085 RB denotes not
T11819 16086-16097 JJ denotes significant
T11820 16098-16100 IN denotes at
T11821 16101-16102 DT denotes a
T11823 16103-16111 JJ denotes critical
T11824 16112-16113 NN denotes P
T11825 16114-16115 SYM denotes <
T11822 16116-16121 CD denotes 0.005
T11826 16121-16123 , denotes ,
T11827 16123-16131 IN denotes although
T11829 16132-16138 RB denotes almost
T11830 16139-16142 DT denotes all
T11828 16143-16147 VBD denotes were
T11831 16148-16150 IN denotes at
T11832 16151-16152 DT denotes a
T11834 16153-16160 JJ denotes nominal
T11835 16161-16162 NN denotes P
T11836 16163-16164 SYM denotes <
T11833 16165-16169 CD denotes 0.05
T11837 16169-16170 . denotes .
T11838 16170-16342 sentence denotes Following the same trend, males displayed an increase in tail length and a small suggestive increase in NA (P = 0.06), while females displayed significant decreases in NA.
T11839 16171-16180 VBG denotes Following
T11841 16181-16184 DT denotes the
T11843 16185-16189 JJ denotes same
T11842 16190-16195 NN denotes trend
T11844 16195-16197 , denotes ,
T11845 16197-16202 NNS denotes males
T11840 16203-16212 VBD denotes displayed
T11846 16213-16215 DT denotes an
T11847 16216-16224 NN denotes increase
T11848 16225-16227 IN denotes in
T11849 16228-16232 NN denotes tail
T11850 16233-16239 NN denotes length
T11851 16240-16243 CC denotes and
T11852 16244-16245 DT denotes a
T11854 16246-16251 JJ denotes small
T11855 16252-16262 JJ denotes suggestive
T11853 16263-16271 NN denotes increase
T11856 16272-16274 IN denotes in
T11857 16275-16277 NN denotes NA
T11858 16278-16279 -LRB- denotes (
T11860 16279-16280 NN denotes P
T11861 16281-16282 SYM denotes =
T11859 16283-16287 CD denotes 0.06
T11862 16287-16288 -RRB- denotes )
T11863 16288-16290 , denotes ,
T11864 16290-16295 IN denotes while
T11866 16296-16303 NNS denotes females
T11865 16304-16313 VBD denotes displayed
T11867 16314-16325 JJ denotes significant
T11868 16326-16335 NNS denotes decreases
T11869 16336-16338 IN denotes in
T11870 16339-16341 NN denotes NA
T11871 16341-16342 . denotes .
T11872 16342-16515 sentence denotes In support of the sex-specific QTL effects strain by sex interactions (P < 0.04) were seen for the following growth traits: 3WK, 6WK, 9WK, G26, G29 and NA (data not shown).
T11873 16343-16345 IN denotes In
T11875 16346-16353 NN denotes support
T11876 16354-16356 IN denotes of
T11877 16357-16360 DT denotes the
T11879 16361-16364 NN denotes sex
T11881 16364-16365 HYPH denotes -
T11880 16365-16373 JJ denotes specific
T11878 16374-16377 NN denotes QTL
T11882 16378-16385 NNS denotes effects
T11883 16386-16392 NN denotes strain
T11885 16393-16395 IN denotes by
T11886 16396-16399 NN denotes sex
T11884 16400-16412 NNS denotes interactions
T11887 16413-16414 -LRB- denotes (
T11889 16414-16415 NN denotes P
T11890 16416-16417 SYM denotes <
T11888 16418-16422 CD denotes 0.04
T11891 16422-16423 -RRB- denotes )
T11892 16424-16428 VBD denotes were
T11874 16429-16433 VBN denotes seen
T11893 16434-16437 IN denotes for
T11894 16438-16441 DT denotes the
T11896 16442-16451 JJ denotes following
T11897 16452-16458 NN denotes growth
T11895 16459-16465 NNS denotes traits
T11898 16465-16467 : denotes :
T11899 16467-16470 NN denotes 3WK
T11900 16470-16472 , denotes ,
T11901 16472-16475 NN denotes 6WK
T11902 16475-16477 , denotes ,
T11903 16477-16480 NN denotes 9WK
T11904 16480-16482 , denotes ,
T11905 16482-16485 NN denotes G26
T11906 16485-16487 , denotes ,
T11907 16487-16490 NN denotes G29
T11908 16491-16494 CC denotes and
T11909 16495-16497 NN denotes NA
T11910 16498-16499 -LRB- denotes (
T11912 16499-16503 NNS denotes data
T11913 16504-16507 RB denotes not
T11911 16508-16513 VBN denotes shown
T11914 16513-16514 -RRB- denotes )
T11915 16514-16515 . denotes .
T11916 16515-16601 sentence denotes The basis of each interaction was an increase in the males and a decrease in females.
T11917 16516-16519 DT denotes The
T11918 16520-16525 NN denotes basis
T11920 16526-16528 IN denotes of
T11921 16529-16533 DT denotes each
T11922 16534-16545 NN denotes interaction
T11919 16546-16549 VBD denotes was
T11923 16550-16552 DT denotes an
T11924 16553-16561 NN denotes increase
T11925 16562-16564 IN denotes in
T11926 16565-16568 DT denotes the
T11927 16569-16574 NNS denotes males
T11928 16575-16578 CC denotes and
T11929 16579-16580 DT denotes a
T11930 16581-16589 NN denotes decrease
T11931 16590-16592 IN denotes in
T11932 16593-16600 NNS denotes females
T11933 16600-16601 . denotes .
T11934 16601-16764 sentence denotes In our analysis of the HGC, HG11 and HG17 strains, concordant results were observed measuring adiposity using chemical lipid extraction and weighing fat pad mass.
T11935 16602-16604 IN denotes In
T11937 16605-16608 PRP$ denotes our
T11938 16609-16617 NN denotes analysis
T11939 16618-16620 IN denotes of
T11940 16621-16624 DT denotes the
T11942 16625-16628 NN denotes HGC
T11943 16628-16630 , denotes ,
T11944 16630-16634 NN denotes HG11
T11945 16635-16638 CC denotes and
T11946 16639-16643 NN denotes HG17
T11941 16644-16651 NNS denotes strains
T11947 16651-16653 , denotes ,
T11948 16653-16663 JJ denotes concordant
T11949 16664-16671 NNS denotes results
T11950 16672-16676 VBD denotes were
T11936 16677-16685 VBN denotes observed
T11951 16686-16695 VBG denotes measuring
T11952 16696-16705 NN denotes adiposity
T11953 16706-16711 VBG denotes using
T11954 16712-16720 JJ denotes chemical
T11956 16721-16726 NN denotes lipid
T11955 16727-16737 NN denotes extraction
T11957 16738-16741 CC denotes and
T11958 16742-16750 VBG denotes weighing
T11959 16751-16754 NN denotes fat
T11960 16755-16758 NN denotes pad
T11961 16759-16763 NN denotes mass
T11962 16763-16764 . denotes .
T11963 16764-17058 sentence denotes The phenotypic correlation between carcass fat (FAT) as a percent of the empty carcass weight (ECW; weight of total body (including organs) minus the head and gastrointestinal tract) (%FAT) determined by chemical analysis and AI, using data from all three lines (HGC, HG11 and HG17), was 0.92.
T11964 16765-16768 DT denotes The
T11966 16769-16779 JJ denotes phenotypic
T11965 16780-16791 NN denotes correlation
T11968 16792-16799 IN denotes between
T11969 16800-16807 NN denotes carcass
T11970 16808-16811 NN denotes fat
T11971 16812-16813 -LRB- denotes (
T11972 16813-16816 NN denotes FAT
T11973 16816-16817 -RRB- denotes )
T11974 16818-16820 IN denotes as
T11975 16821-16822 DT denotes a
T11976 16823-16830 NN denotes percent
T11977 16831-16833 IN denotes of
T11978 16834-16837 DT denotes the
T11980 16838-16843 JJ denotes empty
T11981 16844-16851 NN denotes carcass
T11979 16852-16858 NN denotes weight
T11982 16859-16860 -LRB- denotes (
T11983 16860-16863 NN denotes ECW
T11984 16863-16864 : denotes ;
T11985 16865-16871 NN denotes weight
T11986 16872-16874 IN denotes of
T11987 16875-16880 JJ denotes total
T11988 16881-16885 NN denotes body
T11989 16886-16887 -LRB- denotes (
T11990 16887-16896 VBG denotes including
T11991 16897-16903 NNS denotes organs
T11992 16903-16904 -RRB- denotes )
T11993 16905-16910 CC denotes minus
T11994 16911-16914 DT denotes the
T11995 16915-16919 NN denotes head
T11996 16920-16923 CC denotes and
T11997 16924-16940 JJ denotes gastrointestinal
T11998 16941-16946 NN denotes tract
T11999 16946-16947 -RRB- denotes )
T12000 16948-16949 -LRB- denotes (
T12001 16949-16950 NN denotes %
T12002 16950-16953 NN denotes FAT
T12003 16953-16954 -RRB- denotes )
T12004 16955-16965 VBN denotes determined
T12005 16966-16968 IN denotes by
T12006 16969-16977 JJ denotes chemical
T12007 16978-16986 NN denotes analysis
T12008 16987-16990 CC denotes and
T12009 16991-16993 NN denotes AI
T12010 16993-16995 , denotes ,
T12011 16995-17000 VBG denotes using
T12012 17001-17005 NNS denotes data
T12013 17006-17010 IN denotes from
T12014 17011-17014 DT denotes all
T12016 17015-17020 CD denotes three
T12015 17021-17026 NNS denotes lines
T12017 17027-17028 -LRB- denotes (
T12018 17028-17031 NN denotes HGC
T12019 17031-17033 , denotes ,
T12020 17033-17037 NN denotes HG11
T12021 17038-17041 CC denotes and
T12022 17042-17046 NN denotes HG17
T12023 17046-17047 -RRB- denotes )
T12024 17047-17049 , denotes ,
T11967 17049-17052 VBD denotes was
T12025 17053-17057 CD denotes 0.92
T12026 17057-17058 . denotes .
T12027 17058-17268 sentence denotes These data suggest that individual fat pad dissection is an excellent proxy for measuring whole body adiposity and provides a much more sensitive technique to measure fat accumulation in specific body regions.
T12028 17059-17064 DT denotes These
T12029 17065-17069 NNS denotes data
T12030 17070-17077 VBP denotes suggest
T12031 17078-17082 IN denotes that
T12033 17083-17093 JJ denotes individual
T12035 17094-17097 NN denotes fat
T12036 17098-17101 NN denotes pad
T12034 17102-17112 NN denotes dissection
T12032 17113-17115 VBZ denotes is
T12037 17116-17118 DT denotes an
T12039 17119-17128 JJ denotes excellent
T12038 17129-17134 NN denotes proxy
T12040 17135-17138 IN denotes for
T12041 17139-17148 VBG denotes measuring
T12042 17149-17154 JJ denotes whole
T12043 17155-17159 NN denotes body
T12044 17160-17169 NN denotes adiposity
T12045 17170-17173 CC denotes and
T12046 17174-17182 VBZ denotes provides
T12047 17183-17184 DT denotes a
T12049 17185-17189 RB denotes much
T12050 17190-17194 RBR denotes more
T12051 17195-17204 JJ denotes sensitive
T12048 17205-17214 NN denotes technique
T12052 17215-17217 TO denotes to
T12053 17218-17225 VB denotes measure
T12054 17226-17229 NN denotes fat
T12055 17230-17242 NN denotes accumulation
T12056 17243-17245 IN denotes in
T12057 17246-17254 JJ denotes specific
T12059 17255-17259 NN denotes body
T12058 17260-17267 NNS denotes regions
T12060 17267-17268 . denotes .
T12061 17268-17412 sentence denotes HG11 females displayed slight increases in all fat pads (except MFP) and AI, although, only the 16.5% increase in AI was significant (Table 5).
T12062 17269-17273 NN denotes HG11
T12063 17274-17281 NNS denotes females
T12064 17282-17291 VBD denotes displayed
T12065 17292-17298 JJ denotes slight
T12066 17299-17308 NNS denotes increases
T12067 17309-17311 IN denotes in
T12068 17312-17315 DT denotes all
T12070 17316-17319 NN denotes fat
T12069 17320-17324 NNS denotes pads
T12071 17325-17326 -LRB- denotes (
T12072 17326-17332 IN denotes except
T12073 17333-17336 NN denotes MFP
T12074 17336-17337 -RRB- denotes )
T12075 17338-17341 CC denotes and
T12076 17342-17344 NN denotes AI
T12077 17344-17346 , denotes ,
T12078 17346-17354 IN denotes although
T12080 17354-17356 , denotes ,
T12081 17356-17360 RB denotes only
T12083 17361-17364 DT denotes the
T12084 17365-17369 CD denotes 16.5
T12085 17369-17370 NN denotes %
T12082 17371-17379 NN denotes increase
T12086 17380-17382 IN denotes in
T12087 17383-17385 NN denotes AI
T12079 17386-17389 VBD denotes was
T12088 17390-17401 JJ denotes significant
T12089 17402-17403 -LRB- denotes (
T12090 17403-17408 NN denotes Table
T12091 17409-17410 CD denotes 5
T12092 17410-17411 -RRB- denotes )
T12093 17411-17412 . denotes .
T12094 17412-17562 sentence denotes In contrast, HG11 males did not show a difference in fat mass leading to a significant strain by sex interaction (P = 0.008) for AI (data not shown).
T12095 17413-17415 IN denotes In
T12097 17416-17424 NN denotes contrast
T12098 17424-17426 , denotes ,
T12099 17426-17430 NN denotes HG11
T12100 17431-17436 NNS denotes males
T12101 17437-17440 VBD denotes did
T12102 17441-17444 RB denotes not
T12096 17445-17449 VB denotes show
T12103 17450-17451 DT denotes a
T12104 17452-17462 NN denotes difference
T12105 17463-17465 IN denotes in
T12106 17466-17469 NN denotes fat
T12107 17470-17474 NN denotes mass
T12108 17475-17482 VBG denotes leading
T12109 17483-17485 IN denotes to
T12110 17486-17487 DT denotes a
T12112 17488-17499 JJ denotes significant
T12113 17500-17506 NN denotes strain
T12114 17507-17509 IN denotes by
T12115 17510-17513 NN denotes sex
T12111 17514-17525 NN denotes interaction
T12116 17526-17527 -LRB- denotes (
T12118 17527-17528 NN denotes P
T12119 17529-17530 SYM denotes =
T12117 17531-17536 CD denotes 0.008
T12120 17536-17537 -RRB- denotes )
T12121 17538-17541 IN denotes for
T12122 17542-17544 NN denotes AI
T12123 17545-17546 -LRB- denotes (
T12125 17546-17550 NNS denotes data
T12126 17551-17554 RB denotes not
T12124 17555-17560 VBN denotes shown
T12127 17560-17561 -RRB- denotes )
T12128 17561-17562 . denotes .
T12129 17562-17682 sentence denotes Identical to the results obtained using fat pad weights; female HG11 carcasses displayed an increase in %FAT (Table 6).
T12130 17563-17572 JJ denotes Identical
T12132 17573-17575 IN denotes to
T12133 17576-17579 DT denotes the
T12134 17580-17587 NNS denotes results
T12135 17588-17596 VBN denotes obtained
T12136 17597-17602 VBG denotes using
T12137 17603-17606 NN denotes fat
T12138 17607-17610 NN denotes pad
T12139 17611-17618 NNS denotes weights
T12140 17618-17619 : denotes ;
T12141 17620-17626 JJ denotes female
T12143 17627-17631 NN denotes HG11
T12142 17632-17641 NNS denotes carcasses
T12131 17642-17651 VBD denotes displayed
T12144 17652-17654 DT denotes an
T12145 17655-17663 NN denotes increase
T12146 17664-17666 IN denotes in
T12147 17667-17668 NN denotes %
T12148 17668-17671 NN denotes FAT
T12149 17672-17673 -LRB- denotes (
T12150 17673-17678 NN denotes Table
T12151 17679-17680 CD denotes 6
T12152 17680-17681 -RRB- denotes )
T12153 17681-17682 . denotes .
T12154 17682-17835 sentence denotes HG11 male carcasses had higher levels carcass ash (ASH) as a percent of ECW (%ASH) and female carcasses displayed lower levels of H2O and ASH (Table 6).
T12155 17683-17687 NN denotes HG11
T12157 17688-17692 JJ denotes male
T12156 17693-17702 NNS denotes carcasses
T12158 17703-17706 VBD denotes had
T12159 17707-17713 JJR denotes higher
T12160 17714-17720 NNS denotes levels
T12161 17721-17728 NN denotes carcass
T12162 17729-17732 NN denotes ash
T12163 17733-17734 -LRB- denotes (
T12164 17734-17737 NN denotes ASH
T12165 17737-17738 -RRB- denotes )
T12166 17739-17741 IN denotes as
T12167 17742-17743 DT denotes a
T12168 17744-17751 NN denotes percent
T12169 17752-17754 IN denotes of
T12170 17755-17758 NN denotes ECW
T12171 17759-17760 -LRB- denotes (
T12172 17760-17761 NN denotes %
T12173 17761-17764 NN denotes ASH
T12174 17764-17765 -RRB- denotes )
T12175 17766-17769 CC denotes and
T12176 17770-17776 JJ denotes female
T12177 17777-17786 NNS denotes carcasses
T12178 17787-17796 VBD denotes displayed
T12179 17797-17802 JJR denotes lower
T12180 17803-17809 NNS denotes levels
T12181 17810-17812 IN denotes of
T12182 17813-17816 NN denotes H2O
T12183 17817-17820 CC denotes and
T12184 17821-17824 NN denotes ASH
T12185 17825-17826 -LRB- denotes (
T12186 17826-17831 NN denotes Table
T12187 17832-17833 CD denotes 6
T12188 17833-17834 -RRB- denotes )
T12189 17834-17835 . denotes .
T12190 17835-17943 sentence denotes Strains by sex interactions (P < 0.005) were identified for H2O, %H2O, %FAT, ASH and PROT (data not shown).
T12191 17836-17843 NNS denotes Strains
T12193 17844-17846 IN denotes by
T12194 17847-17850 NN denotes sex
T12192 17851-17863 NNS denotes interactions
T12196 17864-17865 -LRB- denotes (
T12198 17865-17866 NN denotes P
T12199 17867-17868 SYM denotes <
T12197 17869-17874 CD denotes 0.005
T12200 17874-17875 -RRB- denotes )
T12201 17876-17880 VBD denotes were
T12195 17881-17891 VBN denotes identified
T12202 17892-17895 IN denotes for
T12203 17896-17899 NN denotes H2O
T12204 17899-17901 , denotes ,
T12205 17901-17902 NN denotes %
T12206 17902-17905 NN denotes H2O
T12207 17905-17907 , denotes ,
T12208 17907-17908 NN denotes %
T12209 17908-17911 NN denotes FAT
T12210 17911-17913 , denotes ,
T12211 17913-17916 NN denotes ASH
T12212 17917-17920 CC denotes and
T12213 17921-17925 NN denotes PROT
T12214 17926-17927 -LRB- denotes (
T12216 17927-17931 NNS denotes data
T12217 17932-17935 RB denotes not
T12215 17936-17941 VBN denotes shown
T12218 17941-17942 -RRB- denotes )
T12219 17942-17943 . denotes .
T12220 17943-18188 sentence denotes If the aggregate phenotype in HG11 is due to a single locus, its function may be to disrupt energy partitioning by decreasing the deposition of lean tissue and increasing lipid accumulation in females, while having the opposite action in males.
T12221 17944-17946 IN denotes If
T12223 17947-17950 DT denotes the
T12225 17951-17960 JJ denotes aggregate
T12224 17961-17970 NN denotes phenotype
T12226 17971-17973 IN denotes in
T12227 17974-17978 NN denotes HG11
T12222 17979-17981 VBZ denotes is
T12229 17982-17985 IN denotes due
T12230 17986-17988 IN denotes to
T12231 17989-17990 DT denotes a
T12233 17991-17997 JJ denotes single
T12232 17998-18003 NN denotes locus
T12234 18003-18005 , denotes ,
T12235 18005-18008 PRP$ denotes its
T12236 18009-18017 NN denotes function
T12237 18018-18021 MD denotes may
T12228 18022-18024 VB denotes be
T12238 18025-18027 TO denotes to
T12239 18028-18035 VB denotes disrupt
T12240 18036-18042 NN denotes energy
T12241 18043-18055 NN denotes partitioning
T12242 18056-18058 IN denotes by
T12243 18059-18069 VBG denotes decreasing
T12244 18070-18073 DT denotes the
T12245 18074-18084 NN denotes deposition
T12246 18085-18087 IN denotes of
T12247 18088-18092 JJ denotes lean
T12248 18093-18099 NN denotes tissue
T12249 18100-18103 CC denotes and
T12250 18104-18114 VBG denotes increasing
T12251 18115-18120 NN denotes lipid
T12252 18121-18133 NN denotes accumulation
T12253 18134-18136 IN denotes in
T12254 18137-18144 NNS denotes females
T12255 18144-18146 , denotes ,
T12256 18146-18151 IN denotes while
T12257 18152-18158 VBG denotes having
T12258 18159-18162 DT denotes the
T12260 18163-18171 JJ denotes opposite
T12259 18172-18178 NN denotes action
T12261 18179-18181 IN denotes in
T12262 18182-18187 NNS denotes males
T12263 18187-18188 . denotes .
T12264 18188-18267 sentence denotes However, it may also be due to distinct sex-specific QTL with opposing action.
T12265 18189-18196 RB denotes However
T12267 18196-18198 , denotes ,
T12268 18198-18200 PRP denotes it
T12269 18201-18204 MD denotes may
T12270 18205-18209 RB denotes also
T12266 18210-18212 VB denotes be
T12271 18213-18216 IN denotes due
T12272 18217-18219 IN denotes to
T12273 18220-18228 JJ denotes distinct
T12275 18229-18232 NN denotes sex
T12277 18232-18233 HYPH denotes -
T12276 18233-18241 JJ denotes specific
T12274 18242-18245 NN denotes QTL
T12278 18246-18250 IN denotes with
T12279 18251-18259 VBG denotes opposing
T12280 18260-18266 NN denotes action
T12281 18266-18267 . denotes .
T12282 18267-18273 sentence denotes HG17
T12283 18269-18273 NN denotes HG17
T12284 18273-18440 sentence denotes In the original intercross CAST alleles at MMU17 markers were associated with decreases in femur length, ASH and PROT [24] and similar results were seen in HG17 mice.
T12285 18274-18276 IN denotes In
T12287 18277-18280 DT denotes the
T12289 18281-18289 JJ denotes original
T12288 18290-18300 NN denotes intercross
T12290 18301-18305 NN denotes CAST
T12291 18306-18313 NNS denotes alleles
T12292 18314-18316 IN denotes at
T12293 18317-18322 NN denotes MMU17
T12294 18323-18330 NNS denotes markers
T12295 18331-18335 VBD denotes were
T12286 18336-18346 VBN denotes associated
T12296 18347-18351 IN denotes with
T12297 18352-18361 NNS denotes decreases
T12298 18362-18364 IN denotes in
T12299 18365-18370 NN denotes femur
T12300 18371-18377 NN denotes length
T12301 18377-18379 , denotes ,
T12302 18379-18382 NN denotes ASH
T12303 18383-18386 CC denotes and
T12304 18387-18391 NN denotes PROT
T12305 18392-18393 -LRB- denotes [
T12306 18393-18395 CD denotes 24
T12307 18395-18396 -RRB- denotes ]
T12308 18397-18400 CC denotes and
T12309 18401-18408 JJ denotes similar
T12310 18409-18416 NNS denotes results
T12312 18417-18421 VBD denotes were
T12311 18422-18426 VBN denotes seen
T12313 18427-18429 IN denotes in
T12314 18430-18434 NN denotes HG17
T12315 18435-18439 NNS denotes mice
T12316 18439-18440 . denotes .
T12317 18440-18602 sentence denotes Interestingly, both sexes were heavier at 2WK (males, P = 0.0045; females, P = 0.0342), but lighter at 9WK, leading to substantially lower G26 and G29 (Table 4).
T12318 18441-18454 RB denotes Interestingly
T12320 18454-18456 , denotes ,
T12321 18456-18460 DT denotes both
T12322 18461-18466 NNS denotes sexes
T12319 18467-18471 VBD denotes were
T12323 18472-18479 JJR denotes heavier
T12324 18480-18482 IN denotes at
T12325 18483-18486 NN denotes 2WK
T12326 18487-18488 -LRB- denotes (
T12328 18488-18493 NNS denotes males
T12330 18493-18495 , denotes ,
T12331 18495-18496 NN denotes P
T12332 18497-18498 SYM denotes =
T12329 18499-18505 CD denotes 0.0045
T12333 18505-18506 : denotes ;
T12334 18507-18514 NNS denotes females
T12335 18514-18516 , denotes ,
T12336 18516-18517 NN denotes P
T12337 18518-18519 SYM denotes =
T12327 18520-18526 CD denotes 0.0342
T12338 18526-18527 -RRB- denotes )
T12339 18527-18529 , denotes ,
T12340 18529-18532 CC denotes but
T12341 18533-18540 JJR denotes lighter
T12342 18541-18543 IN denotes at
T12343 18544-18547 NN denotes 9WK
T12344 18547-18549 , denotes ,
T12345 18549-18556 VBG denotes leading
T12346 18557-18559 IN denotes to
T12347 18560-18573 RB denotes substantially
T12348 18574-18579 JJR denotes lower
T12349 18580-18583 NN denotes G26
T12350 18584-18587 CC denotes and
T12351 18588-18591 NN denotes G29
T12352 18592-18593 -LRB- denotes (
T12353 18593-18598 NN denotes Table
T12354 18599-18600 CD denotes 4
T12355 18600-18601 -RRB- denotes )
T12356 18601-18602 . denotes .
T12357 18602-18682 sentence denotes In general growth differences ranged between 5% and 15% lower in congenic mice.
T12358 18603-18605 IN denotes In
T12360 18606-18613 JJ denotes general
T12361 18614-18620 NN denotes growth
T12362 18621-18632 NNS denotes differences
T12359 18633-18639 VBD denotes ranged
T12363 18640-18647 IN denotes between
T12364 18648-18649 CD denotes 5
T12365 18649-18650 NN denotes %
T12366 18651-18654 CC denotes and
T12367 18655-18657 CD denotes 15
T12368 18657-18658 NN denotes %
T12369 18659-18664 JJR denotes lower
T12370 18665-18667 IN denotes in
T12371 18668-18676 JJ denotes congenic
T12372 18677-18681 NNS denotes mice
T12373 18681-18682 . denotes .
T12374 18682-18763 sentence denotes Both sexes had significant reductions in length traits relative to control mice.
T12375 18683-18687 DT denotes Both
T12376 18688-18693 NNS denotes sexes
T12377 18694-18697 VBD denotes had
T12378 18698-18709 JJ denotes significant
T12379 18710-18720 NNS denotes reductions
T12380 18721-18723 IN denotes in
T12381 18724-18730 NN denotes length
T12382 18731-18737 NNS denotes traits
T12383 18738-18746 JJ denotes relative
T12384 18747-18749 IN denotes to
T12385 18750-18757 NN denotes control
T12386 18758-18762 NNS denotes mice
T12387 18762-18763 . denotes .
T12388 18763-18854 sentence denotes NA was reduced by 2.7% (P = 0.0186) and 3.4% in males and females, respectively (Table 4).
T12389 18764-18766 NN denotes NA
T12391 18767-18770 VBD denotes was
T12390 18771-18778 VBN denotes reduced
T12392 18779-18781 IN denotes by
T12393 18782-18785 CD denotes 2.7
T12394 18785-18786 NN denotes %
T12395 18787-18788 -LRB- denotes (
T12397 18788-18789 NN denotes P
T12398 18790-18791 SYM denotes =
T12396 18792-18798 CD denotes 0.0186
T12399 18798-18799 -RRB- denotes )
T12400 18800-18803 CC denotes and
T12401 18804-18807 CD denotes 3.4
T12402 18807-18808 NN denotes %
T12403 18809-18811 IN denotes in
T12404 18812-18817 NNS denotes males
T12405 18818-18821 CC denotes and
T12406 18822-18829 NNS denotes females
T12407 18829-18831 , denotes ,
T12408 18831-18843 RB denotes respectively
T12409 18844-18845 -LRB- denotes (
T12410 18845-18850 NN denotes Table
T12411 18851-18852 CD denotes 4
T12412 18852-18853 -RRB- denotes )
T12413 18853-18854 . denotes .
T12414 18854-18929 sentence denotes In addition, tail was reduced by approximately 6% in both sexes (Table 4).
T12415 18855-18857 IN denotes In
T12417 18858-18866 NN denotes addition
T12418 18866-18868 , denotes ,
T12419 18868-18872 NN denotes tail
T12420 18873-18876 VBD denotes was
T12416 18877-18884 VBN denotes reduced
T12421 18885-18887 IN denotes by
T12422 18888-18901 RB denotes approximately
T12423 18902-18903 CD denotes 6
T12424 18903-18904 NN denotes %
T12425 18905-18907 IN denotes in
T12426 18908-18912 DT denotes both
T12427 18913-18918 NNS denotes sexes
T12428 18919-18920 -LRB- denotes (
T12429 18920-18925 NN denotes Table
T12430 18926-18927 CD denotes 4
T12431 18927-18928 -RRB- denotes )
T12432 18928-18929 . denotes .
T12433 18929-19022 sentence denotes In general, HG17 mice displayed increases in all fat pads (except MFP), TF and AI (Table 5).
T12434 18930-18932 IN denotes In
T12436 18933-18940 JJ denotes general
T12437 18940-18942 , denotes ,
T12438 18942-18946 NN denotes HG17
T12439 18947-18951 NNS denotes mice
T12435 18952-18961 VBD denotes displayed
T12440 18962-18971 NNS denotes increases
T12441 18972-18974 IN denotes in
T12442 18975-18978 DT denotes all
T12444 18979-18982 NN denotes fat
T12443 18983-18987 NNS denotes pads
T12445 18988-18989 -LRB- denotes (
T12446 18989-18995 IN denotes except
T12447 18996-18999 NN denotes MFP
T12448 18999-19000 -RRB- denotes )
T12449 19000-19002 , denotes ,
T12450 19002-19004 NN denotes TF
T12451 19005-19008 CC denotes and
T12452 19009-19011 NN denotes AI
T12453 19012-19013 -LRB- denotes (
T12454 19013-19018 NN denotes Table
T12455 19019-19020 CD denotes 5
T12456 19020-19021 -RRB- denotes )
T12457 19021-19022 . denotes .
T12458 19022-19097 sentence denotes However, none of these differences were significant at critical P < 0.005.
T12459 19023-19030 RB denotes However
T12461 19030-19032 , denotes ,
T12462 19032-19036 NN denotes none
T12463 19037-19039 IN denotes of
T12464 19040-19045 DT denotes these
T12465 19046-19057 NNS denotes differences
T12460 19058-19062 VBD denotes were
T12466 19063-19074 JJ denotes significant
T12467 19075-19077 IN denotes at
T12468 19078-19086 JJ denotes critical
T12470 19087-19088 NN denotes P
T12471 19089-19090 SYM denotes <
T12469 19091-19096 CD denotes 0.005
T12472 19096-19097 . denotes .
T12473 19097-19256 sentence denotes In addition, HG17 male carcasses possessed lower levels of H2O and ASH, while female carcasses contained lower levels of % H2O, ASH, %ASH and %PROT (Table 6).
T12474 19098-19100 IN denotes In
T12476 19101-19109 NN denotes addition
T12477 19109-19111 , denotes ,
T12478 19111-19115 NN denotes HG17
T12480 19116-19120 JJ denotes male
T12479 19121-19130 NNS denotes carcasses
T12475 19131-19140 VBD denotes possessed
T12481 19141-19146 JJR denotes lower
T12482 19147-19153 NNS denotes levels
T12483 19154-19156 IN denotes of
T12484 19157-19160 NN denotes H2O
T12485 19161-19164 CC denotes and
T12486 19165-19168 NN denotes ASH
T12487 19168-19170 , denotes ,
T12488 19170-19175 IN denotes while
T12490 19176-19182 JJ denotes female
T12491 19183-19192 NNS denotes carcasses
T12489 19193-19202 VBD denotes contained
T12492 19203-19208 JJR denotes lower
T12493 19209-19215 NNS denotes levels
T12494 19216-19218 IN denotes of
T12495 19219-19220 NN denotes %
T12496 19221-19224 NN denotes H2O
T12497 19224-19226 , denotes ,
T12498 19226-19229 NN denotes ASH
T12499 19229-19231 , denotes ,
T12500 19231-19232 NN denotes %
T12501 19232-19235 NN denotes ASH
T12502 19236-19239 CC denotes and
T12503 19240-19241 NN denotes %
T12504 19241-19245 NN denotes PROT
T12505 19246-19247 -LRB- denotes (
T12506 19247-19252 NN denotes Table
T12507 19253-19254 CD denotes 6
T12508 19254-19255 -RRB- denotes )
T12509 19255-19256 . denotes .
T13271 19258-19261 NN denotes MMU
T13272 19261-19262 CD denotes 2
T13274 19262-19264 , denotes ,
T13275 19264-19265 CD denotes 9
T13276 19265-19267 , denotes ,
T13277 19267-19269 CD denotes 11
T13278 19270-19273 CC denotes and
T13279 19274-19276 CD denotes 17
T13280 19277-19279 NN denotes hg
T13281 19280-19288 NN denotes modifier
T13282 19289-19298 NN denotes candidate
T13283 19299-19303 NN denotes gene
T13273 19304-19314 NN denotes sequencing
T13284 19314-19528 sentence denotes The HG phenotype is due to the deletion of Socs2, therefore we reasoned that QTL on MMU2, 9, 11 and 17 interacting with hg possibly represent variation within genes participating in various aspects of Gh function.
T13285 19315-19318 DT denotes The
T13287 19319-19321 NN denotes HG
T13286 19322-19331 NN denotes phenotype
T13288 19332-19334 VBZ denotes is
T13290 19335-19338 IN denotes due
T13291 19339-19341 IN denotes to
T13292 19342-19345 DT denotes the
T13293 19346-19354 NN denotes deletion
T13294 19355-19357 IN denotes of
T13295 19358-19363 NN denotes Socs2
T13296 19363-19365 , denotes ,
T13297 19365-19374 RB denotes therefore
T13298 19375-19377 PRP denotes we
T13289 19378-19386 VBD denotes reasoned
T13299 19387-19391 IN denotes that
T13301 19392-19395 NN denotes QTL
T13302 19396-19398 IN denotes on
T13303 19399-19402 NN denotes MMU
T13304 19402-19403 CD denotes 2
T13305 19403-19405 , denotes ,
T13306 19405-19406 CD denotes 9
T13307 19406-19408 , denotes ,
T13308 19408-19410 CD denotes 11
T13309 19411-19414 CC denotes and
T13310 19415-19417 CD denotes 17
T13311 19418-19429 VBG denotes interacting
T13312 19430-19434 IN denotes with
T13313 19435-19437 NN denotes hg
T13314 19438-19446 RB denotes possibly
T13300 19447-19456 VBP denotes represent
T13315 19457-19466 NN denotes variation
T13316 19467-19473 IN denotes within
T13317 19474-19479 NNS denotes genes
T13318 19480-19493 VBG denotes participating
T13319 19494-19496 IN denotes in
T13320 19497-19504 JJ denotes various
T13321 19505-19512 NNS denotes aspects
T13322 19513-19515 IN denotes of
T13323 19516-19518 NN denotes Gh
T13324 19519-19527 NN denotes function
T13325 19527-19528 . denotes .
T13326 19528-19706 sentence denotes To select candidate genes for sequencing we identified genes known to be or potentially involved in Gh signaling, are responsive to Gh or that propagate downstream Gh functions.
T13327 19529-19531 TO denotes To
T13328 19532-19538 VB denotes select
T13330 19539-19548 NN denotes candidate
T13331 19549-19554 NNS denotes genes
T13332 19555-19558 IN denotes for
T13333 19559-19569 NN denotes sequencing
T13334 19570-19572 PRP denotes we
T13329 19573-19583 VBD denotes identified
T13335 19584-19589 NNS denotes genes
T13336 19590-19595 VBN denotes known
T13337 19596-19598 TO denotes to
T13338 19599-19601 VB denotes be
T13339 19602-19604 CC denotes or
T13340 19605-19616 RB denotes potentially
T13341 19617-19625 VBN denotes involved
T13342 19626-19628 IN denotes in
T13343 19629-19631 NN denotes Gh
T13344 19632-19641 NN denotes signaling
T13345 19641-19643 , denotes ,
T13346 19643-19646 VBP denotes are
T13347 19647-19657 JJ denotes responsive
T13348 19658-19660 IN denotes to
T13349 19661-19663 NN denotes Gh
T13350 19664-19666 CC denotes or
T13351 19667-19671 WDT denotes that
T13352 19672-19681 VBP denotes propagate
T13353 19682-19692 JJ denotes downstream
T13355 19693-19695 NN denotes Gh
T13354 19696-19705 NNS denotes functions
T13356 19705-19706 . denotes .
T13357 19706-19919 sentence denotes Forty-four hg modifier candidate genes were identified from primary literature, reviews and book chapters and coordinated using the GenMAPP (Gene MicroArray Pathway Profiler) pathway building software (Figure 5).
T13358 19707-19712 CD denotes Forty
T13360 19712-19713 HYPH denotes -
T13359 19713-19717 CD denotes four
T13362 19718-19720 NN denotes hg
T13363 19721-19729 NN denotes modifier
T13364 19730-19739 NN denotes candidate
T13361 19740-19745 NNS denotes genes
T13366 19746-19750 VBD denotes were
T13365 19751-19761 VBN denotes identified
T13367 19762-19766 IN denotes from
T13368 19767-19774 JJ denotes primary
T13369 19775-19785 NN denotes literature
T13370 19785-19787 , denotes ,
T13371 19787-19794 NNS denotes reviews
T13372 19795-19798 CC denotes and
T13373 19799-19803 NN denotes book
T13374 19804-19812 NNS denotes chapters
T13375 19813-19816 CC denotes and
T13376 19817-19828 VBN denotes coordinated
T13377 19829-19834 VBG denotes using
T13378 19835-19838 DT denotes the
T13380 19839-19846 NNP denotes GenMAPP
T13381 19847-19848 -LRB- denotes (
T13382 19848-19852 NNP denotes Gene
T13383 19853-19863 NNP denotes MicroArray
T13385 19864-19871 NNP denotes Pathway
T13384 19872-19880 NNP denotes Profiler
T13386 19880-19881 -RRB- denotes )
T13387 19882-19889 NN denotes pathway
T13388 19890-19898 NN denotes building
T13379 19899-19907 NN denotes software
T13389 19908-19909 -LRB- denotes (
T13390 19909-19915 NN denotes Figure
T13391 19916-19917 CD denotes 5
T13392 19917-19918 -RRB- denotes )
T13393 19918-19919 . denotes .
T13394 19919-20083 sentence denotes The coding region of each gene was sequenced from the CAST strain and compared to the publicly available B6 sequence to identify polymorphisms (Additional File 4).
T13395 19920-19923 DT denotes The
T13397 19924-19930 NN denotes coding
T13396 19931-19937 NN denotes region
T13399 19938-19940 IN denotes of
T13400 19941-19945 DT denotes each
T13401 19946-19950 NN denotes gene
T13402 19951-19954 VBD denotes was
T13398 19955-19964 VBN denotes sequenced
T13403 19965-19969 IN denotes from
T13404 19970-19973 DT denotes the
T13406 19974-19978 NN denotes CAST
T13405 19979-19985 NN denotes strain
T13407 19986-19989 CC denotes and
T13408 19990-19998 VBN denotes compared
T13409 19999-20001 IN denotes to
T13410 20002-20005 DT denotes the
T13412 20006-20014 RB denotes publicly
T13413 20015-20024 JJ denotes available
T13414 20025-20027 NN denotes B6
T13411 20028-20036 NN denotes sequence
T13415 20037-20039 TO denotes to
T13416 20040-20048 VB denotes identify
T13417 20049-20062 NNS denotes polymorphisms
T13418 20063-20064 -LRB- denotes (
T13420 20064-20074 JJ denotes Additional
T13419 20075-20079 NN denotes File
T13421 20080-20081 CD denotes 4
T13422 20081-20082 -RRB- denotes )
T13423 20082-20083 . denotes .
T13424 20083-20221 sentence denotes A total of 94.492 kbp was sequenced (75.378 kbp CDS and 19.114 Kbp 5' and 3' untranslated region (UTR)), representing 25,083 amino acids.
T13425 20084-20085 DT denotes A
T13426 20086-20091 NN denotes total
T13428 20092-20094 IN denotes of
T13429 20095-20101 CD denotes 94.492
T13430 20102-20105 NN denotes kbp
T13431 20106-20109 VBD denotes was
T13427 20110-20119 VBN denotes sequenced
T13432 20120-20121 -LRB- denotes (
T13434 20121-20127 CD denotes 75.378
T13435 20128-20131 NN denotes kbp
T13433 20132-20135 NN denotes CDS
T13436 20136-20139 CC denotes and
T13437 20140-20146 CD denotes 19.114
T13438 20147-20150 NN denotes Kbp
T13440 20151-20152 CD denotes 5
T13441 20152-20153 SYM denotes '
T13442 20154-20157 CC denotes and
T13443 20158-20159 CD denotes 3
T13444 20159-20160 SYM denotes '
T13445 20161-20173 JJ denotes untranslated
T13439 20174-20180 NN denotes region
T13446 20181-20182 -LRB- denotes (
T13447 20182-20185 NN denotes UTR
T13448 20185-20186 -RRB- denotes )
T13449 20186-20187 -RRB- denotes )
T13450 20187-20189 , denotes ,
T13451 20189-20201 VBG denotes representing
T13452 20202-20208 CD denotes 25,083
T13454 20209-20214 NN denotes amino
T13453 20215-20220 NNS denotes acids
T13455 20220-20221 . denotes .
T13456 20221-20453 sentence denotes Comparison with the public B6 assembly (May 2004 University of California, Santa Cruz (UCSC [28]) mm5 genome assembly, National Center for Biotechnology Information (NCBI) Build 33) identified 307 polymorphisms between CAST and B6.
T13457 20222-20232 NN denotes Comparison
T13459 20233-20237 IN denotes with
T13460 20238-20241 DT denotes the
T13462 20242-20248 JJ denotes public
T13463 20249-20251 NN denotes B6
T13461 20252-20260 NN denotes assembly
T13464 20261-20262 -LRB- denotes (
T13466 20262-20265 NNP denotes May
T13468 20266-20270 CD denotes 2004
T13467 20271-20281 NNP denotes University
T13469 20282-20284 IN denotes of
T13470 20285-20295 NNP denotes California
T13471 20295-20297 , denotes ,
T13472 20297-20302 NNP denotes Santa
T13473 20303-20307 NNP denotes Cruz
T13474 20308-20309 -LRB- denotes (
T13476 20309-20313 NNP denotes UCSC
T13477 20314-20315 -LRB- denotes [
T13475 20315-20317 CD denotes 28
T13478 20317-20318 -RRB- denotes ]
T13479 20318-20319 -RRB- denotes )
T13480 20320-20323 NN denotes mm5
T13482 20324-20330 NN denotes genome
T13481 20331-20339 NN denotes assembly
T13483 20339-20341 , denotes ,
T13484 20341-20349 NNP denotes National
T13485 20350-20356 NNP denotes Center
T13486 20357-20360 IN denotes for
T13487 20361-20374 NNP denotes Biotechnology
T13488 20375-20386 NNP denotes Information
T13489 20387-20388 -LRB- denotes (
T13490 20388-20392 NNP denotes NCBI
T13491 20392-20393 -RRB- denotes )
T13465 20394-20399 NN denotes Build
T13492 20400-20402 CD denotes 33
T13493 20402-20403 -RRB- denotes )
T13458 20404-20414 VBN denotes identified
T13494 20415-20418 CD denotes 307
T13495 20419-20432 NNS denotes polymorphisms
T13496 20433-20440 IN denotes between
T13497 20441-20445 NN denotes CAST
T13498 20446-20449 CC denotes and
T13499 20450-20452 NN denotes B6
T13500 20452-20453 . denotes .
T13501 20453-20575 sentence denotes Of these, 295 were single nucleotide polymorphisms (SNP) and 12 were insertions or deletions in CAST (Additional File 4).
T13502 20454-20456 IN denotes Of
T13504 20457-20462 DT denotes these
T13505 20462-20464 , denotes ,
T13506 20464-20467 CD denotes 295
T13503 20468-20472 VBD denotes were
T13507 20473-20479 JJ denotes single
T13509 20480-20490 NN denotes nucleotide
T13508 20491-20504 NNS denotes polymorphisms
T13510 20505-20506 -LRB- denotes (
T13511 20506-20509 NN denotes SNP
T13512 20509-20510 -RRB- denotes )
T13513 20511-20514 CC denotes and
T13514 20515-20517 CD denotes 12
T13515 20518-20522 VBD denotes were
T13516 20523-20533 NNS denotes insertions
T13517 20534-20536 CC denotes or
T13518 20537-20546 NNS denotes deletions
T13519 20547-20549 IN denotes in
T13520 20550-20554 NN denotes CAST
T13521 20555-20556 -LRB- denotes (
T13523 20556-20566 JJ denotes Additional
T13522 20567-20571 NN denotes File
T13524 20572-20573 CD denotes 4
T13525 20573-20574 -RRB- denotes )
T13526 20574-20575 . denotes .
T13527 20575-20642 sentence denotes All 12 insertions or deletions were located within 5' and 3' UTRs.
T13528 20576-20579 PDT denotes All
T13530 20580-20582 CD denotes 12
T13529 20583-20593 NNS denotes insertions
T13532 20594-20596 CC denotes or
T13533 20597-20606 NNS denotes deletions
T13534 20607-20611 VBD denotes were
T13531 20612-20619 VBN denotes located
T13535 20620-20626 IN denotes within
T13536 20627-20628 CD denotes 5
T13538 20628-20629 SYM denotes '
T13539 20630-20633 CC denotes and
T13540 20634-20635 CD denotes 3
T13541 20635-20636 SYM denotes '
T13537 20637-20641 NNS denotes UTRs
T13542 20641-20642 . denotes .
T13543 20642-20737 sentence denotes Fifty-six nonsynonomous SNP (nsSNP) were identified in 14 different genes (Additional File 4).
T13544 20643-20648 CD denotes Fifty
T13546 20648-20649 HYPH denotes -
T13545 20649-20652 CD denotes six
T13548 20653-20666 JJ denotes nonsynonomous
T13547 20667-20670 NN denotes SNP
T13550 20671-20672 -LRB- denotes (
T13551 20672-20677 NN denotes nsSNP
T13552 20677-20678 -RRB- denotes )
T13553 20679-20683 VBD denotes were
T13549 20684-20694 VBN denotes identified
T13554 20695-20697 IN denotes in
T13555 20698-20700 CD denotes 14
T13557 20701-20710 JJ denotes different
T13556 20711-20716 NNS denotes genes
T13558 20717-20718 -LRB- denotes (
T13560 20718-20728 JJ denotes Additional
T13559 20729-20733 NN denotes File
T13561 20734-20735 CD denotes 4
T13562 20735-20736 -RRB- denotes )
T13563 20736-20737 . denotes .
T13564 20737-21009 sentence denotes PolyPhen [29] and SIFT [30] are software programs designed to identify nsSNP which potentially alter protein function by evaluating evolutionary conservation at specific amino acid residues using a multiple sequence alignment of protein sequences homologous to the query.
T13565 20738-20746 NNP denotes PolyPhen
T13567 20747-20748 -LRB- denotes [
T13568 20748-20750 CD denotes 29
T13569 20750-20751 -RRB- denotes ]
T13570 20752-20755 CC denotes and
T13571 20756-20760 NN denotes SIFT
T13572 20761-20762 -LRB- denotes [
T13573 20762-20764 CD denotes 30
T13574 20764-20765 -RRB- denotes ]
T13566 20766-20769 VBP denotes are
T13575 20770-20778 NN denotes software
T13576 20779-20787 NNS denotes programs
T13577 20788-20796 VBN denotes designed
T13578 20797-20799 TO denotes to
T13579 20800-20808 VB denotes identify
T13580 20809-20814 NN denotes nsSNP
T13581 20815-20820 WDT denotes which
T13583 20821-20832 RB denotes potentially
T13582 20833-20838 VBP denotes alter
T13584 20839-20846 NN denotes protein
T13585 20847-20855 NN denotes function
T13586 20856-20858 IN denotes by
T13587 20859-20869 VBG denotes evaluating
T13588 20870-20882 JJ denotes evolutionary
T13589 20883-20895 NN denotes conservation
T13590 20896-20898 IN denotes at
T13591 20899-20907 JJ denotes specific
T13593 20908-20913 NN denotes amino
T13594 20914-20918 NN denotes acid
T13592 20919-20927 NNS denotes residues
T13595 20928-20933 VBG denotes using
T13596 20934-20935 DT denotes a
T13598 20936-20944 JJ denotes multiple
T13599 20945-20953 NN denotes sequence
T13597 20954-20963 NN denotes alignment
T13600 20964-20966 IN denotes of
T13601 20967-20974 NN denotes protein
T13602 20975-20984 NNS denotes sequences
T13603 20985-20995 JJ denotes homologous
T13604 20996-20998 IN denotes to
T13605 20999-21002 DT denotes the
T13606 21003-21008 NN denotes query
T13607 21008-21009 . denotes .
T13608 21009-21174 sentence denotes When applied to our data set PolyPhen, SIFT or both programs predicted that 15 of the 56 nsSNP in 9 different genes would possibly alter protein function (Table 7).
T13609 21010-21014 WRB denotes When
T13610 21015-21022 VBN denotes applied
T13612 21023-21025 IN denotes to
T13613 21026-21029 PRP$ denotes our
T13615 21030-21034 NNS denotes data
T13614 21035-21038 NN denotes set
T13616 21039-21047 NNP denotes PolyPhen
T13617 21047-21049 , denotes ,
T13618 21049-21053 NNP denotes SIFT
T13619 21054-21056 CC denotes or
T13620 21057-21061 DT denotes both
T13621 21062-21070 NNS denotes programs
T13611 21071-21080 VBD denotes predicted
T13622 21081-21085 IN denotes that
T13624 21086-21088 CD denotes 15
T13626 21089-21091 IN denotes of
T13627 21092-21095 DT denotes the
T13625 21096-21098 CD denotes 56
T13628 21099-21104 NN denotes nsSNP
T13629 21105-21107 IN denotes in
T13630 21108-21109 CD denotes 9
T13632 21110-21119 JJ denotes different
T13631 21120-21125 NNS denotes genes
T13633 21126-21131 MD denotes would
T13634 21132-21140 RB denotes possibly
T13623 21141-21146 VB denotes alter
T13635 21147-21154 NN denotes protein
T13636 21155-21163 NN denotes function
T13637 21164-21165 -LRB- denotes (
T13638 21165-21170 NN denotes Table
T13639 21171-21172 CD denotes 7
T13640 21172-21173 -RRB- denotes )
T13641 21173-21174 . denotes .
T17718 21187-21192 NN denotes Speed
T17719 21193-21201 JJ denotes congenic
T17720 21202-21209 NNS denotes strains
T17721 21210-21217 VBP denotes provide
T17722 21218-21219 DT denotes a
T17724 21220-21228 JJ denotes powerful
T17723 21229-21237 NN denotes approach
T17725 21238-21240 TO denotes to
T17726 21241-21248 VB denotes confirm
T17727 21249-21252 CC denotes and
T17728 21253-21263 RB denotes physically
T17729 21264-21271 VB denotes confine
T17730 21272-21275 NN denotes QTL
T17731 21276-21282 IN denotes within
T17732 21283-21292 NNS denotes intervals
T17733 21293-21300 VBN denotes defined
T17734 21301-21303 IN denotes by
T17735 21304-21313 JJ denotes molecular
T17736 21314-21321 NNS denotes markers
T17737 21321-21322 . denotes .
T17738 21322-21543 sentence denotes In the current study, approximately 20% of the CAST genome harboring all previously detected growth and carcass composition QTL was isolated on an HG or B6 background through the development of 14 speed congenic strains.
T17739 21323-21325 IN denotes In
T17741 21326-21329 DT denotes the
T17743 21330-21337 JJ denotes current
T17742 21338-21343 NN denotes study
T17744 21343-21345 , denotes ,
T17745 21345-21358 RB denotes approximately
T17746 21359-21361 CD denotes 20
T17747 21361-21362 NN denotes %
T17748 21363-21365 IN denotes of
T17749 21366-21369 DT denotes the
T17751 21370-21374 NN denotes CAST
T17750 21375-21381 NN denotes genome
T17752 21382-21391 VBG denotes harboring
T17753 21392-21395 RB denotes all
T17755 21396-21406 RB denotes previously
T17756 21407-21415 VBN denotes detected
T17757 21416-21422 NN denotes growth
T17759 21423-21426 CC denotes and
T17760 21427-21434 NN denotes carcass
T17758 21435-21446 NN denotes composition
T17754 21447-21450 NN denotes QTL
T17761 21451-21454 VBD denotes was
T17740 21455-21463 VBN denotes isolated
T17762 21464-21466 IN denotes on
T17763 21467-21469 DT denotes an
T17765 21470-21472 NN denotes HG
T17766 21473-21475 CC denotes or
T17767 21476-21478 NN denotes B6
T17764 21479-21489 NN denotes background
T17768 21490-21497 IN denotes through
T17769 21498-21501 DT denotes the
T17770 21502-21513 NN denotes development
T17771 21514-21516 IN denotes of
T17772 21517-21519 CD denotes 14
T17774 21520-21525 NN denotes speed
T17775 21526-21534 JJ denotes congenic
T17773 21535-21542 NNS denotes strains
T17776 21542-21543 . denotes .
T17777 21543-21740 sentence denotes Two distinct speed congenic panels were developed, the first provided a comprehensive isolation of all MMU2 QTL between the B6, HG and CAST strains and the second targeted all QTL outside of MMU2.
T17778 21544-21547 CD denotes Two
T17780 21548-21556 JJ denotes distinct
T17781 21557-21562 NN denotes speed
T17782 21563-21571 JJ denotes congenic
T17779 21572-21578 NNS denotes panels
T17784 21579-21583 VBD denotes were
T17783 21584-21593 VBN denotes developed
T17786 21593-21595 , denotes ,
T17787 21595-21598 DT denotes the
T17788 21599-21604 JJ denotes first
T17785 21605-21613 VBD denotes provided
T17789 21614-21615 DT denotes a
T17791 21616-21629 JJ denotes comprehensive
T17790 21630-21639 NN denotes isolation
T17792 21640-21642 IN denotes of
T17793 21643-21646 DT denotes all
T17795 21647-21651 NN denotes MMU2
T17794 21652-21655 NN denotes QTL
T17796 21656-21663 IN denotes between
T17797 21664-21667 DT denotes the
T17799 21668-21670 NN denotes B6
T17800 21670-21672 , denotes ,
T17801 21672-21674 NN denotes HG
T17802 21675-21678 CC denotes and
T17803 21679-21683 NN denotes CAST
T17798 21684-21691 NNS denotes strains
T17804 21692-21695 CC denotes and
T17805 21696-21699 DT denotes the
T17806 21700-21706 NN denotes second
T17807 21707-21715 VBD denotes targeted
T17808 21716-21719 DT denotes all
T17809 21720-21723 NN denotes QTL
T17810 21724-21731 IN denotes outside
T17811 21732-21734 IN denotes of
T17812 21735-21739 NN denotes MMU2
T17813 21739-21740 . denotes .
T17814 21740-21838 sentence denotes Each successfully characterized strain exhibited phenotypic differences relative to control mice.
T17815 21741-21745 DT denotes Each
T17817 21746-21758 RB denotes successfully
T17818 21759-21772 VBN denotes characterized
T17816 21773-21779 NN denotes strain
T17819 21780-21789 VBD denotes exhibited
T17820 21790-21800 JJ denotes phenotypic
T17821 21801-21812 NNS denotes differences
T17822 21813-21821 JJ denotes relative
T17823 21822-21824 IN denotes to
T17824 21825-21832 NN denotes control
T17825 21833-21837 NNS denotes mice
T17826 21837-21838 . denotes .
T17827 21838-21972 sentence denotes These strains represent important resources and provide the genetic resource to positionally clone numerous quantitative trait genes.
T17828 21839-21844 DT denotes These
T17829 21845-21852 NNS denotes strains
T17830 21853-21862 VBP denotes represent
T17831 21863-21872 JJ denotes important
T17832 21873-21882 NNS denotes resources
T17833 21883-21886 CC denotes and
T17834 21887-21894 VB denotes provide
T17835 21895-21898 DT denotes the
T17837 21899-21906 JJ denotes genetic
T17836 21907-21915 NN denotes resource
T17838 21916-21918 TO denotes to
T17840 21919-21931 RB denotes positionally
T17839 21932-21937 VB denotes clone
T17841 21938-21946 JJ denotes numerous
T17843 21947-21959 JJ denotes quantitative
T17844 21960-21965 NN denotes trait
T17842 21966-21971 NNS denotes genes
T17845 21971-21972 . denotes .
T17846 21972-22117 sentence denotes One criticism of the speed congenic approach is the potential for QTL to reside among unwanted donor alleles not eliminated during backcrossing.
T17847 21973-21976 CD denotes One
T17848 21977-21986 NN denotes criticism
T17850 21987-21989 IN denotes of
T17851 21990-21993 DT denotes the
T17853 21994-21999 NN denotes speed
T17854 22000-22008 JJ denotes congenic
T17852 22009-22017 NN denotes approach
T17849 22018-22020 VBZ denotes is
T17855 22021-22024 DT denotes the
T17856 22025-22034 NN denotes potential
T17857 22035-22038 IN denotes for
T17859 22039-22042 NN denotes QTL
T17860 22043-22045 TO denotes to
T17858 22046-22052 VB denotes reside
T17861 22053-22058 IN denotes among
T17862 22059-22067 JJ denotes unwanted
T17864 22068-22073 NN denotes donor
T17863 22074-22081 NNS denotes alleles
T17865 22082-22085 RB denotes not
T17866 22086-22096 VBN denotes eliminated
T17867 22097-22103 IN denotes during
T17868 22104-22116 NN denotes backcrossing
T17869 22116-22117 . denotes .
T17870 22117-22245 sentence denotes In this case differences between the congenic and control strains would be due in part or whole to these contaminating alleles.
T17871 22118-22120 IN denotes In
T17873 22121-22125 DT denotes this
T17874 22126-22130 NN denotes case
T17875 22131-22142 NNS denotes differences
T17876 22143-22150 IN denotes between
T17877 22151-22154 DT denotes the
T17879 22155-22163 JJ denotes congenic
T17880 22164-22167 CC denotes and
T17881 22168-22175 NN denotes control
T17878 22176-22183 NNS denotes strains
T17882 22184-22189 MD denotes would
T17872 22190-22192 VB denotes be
T17883 22193-22196 IN denotes due
T17884 22197-22199 IN denotes in
T17885 22200-22204 NN denotes part
T17886 22205-22207 CC denotes or
T17887 22208-22213 NN denotes whole
T17888 22214-22216 IN denotes to
T17889 22217-22222 DT denotes these
T17891 22223-22236 VBG denotes contaminating
T17890 22237-22244 NNS denotes alleles
T17892 22244-22245 . denotes .
T17893 22245-22319 sentence denotes We took several precautions to reduce the probability of this occurrence.
T17894 22246-22248 PRP denotes We
T17895 22249-22253 VBD denotes took
T17896 22254-22261 JJ denotes several
T17897 22262-22273 NNS denotes precautions
T17898 22274-22276 TO denotes to
T17899 22277-22283 VB denotes reduce
T17900 22284-22287 DT denotes the
T17901 22288-22299 NN denotes probability
T17902 22300-22302 IN denotes of
T17903 22303-22307 DT denotes this
T17904 22308-22318 NN denotes occurrence
T17905 22318-22319 . denotes .
T17906 22319-22432 sentence denotes First, our control strains were developed from mice undergoing the same selection as all of the other congenics.
T17907 22320-22325 RB denotes First
T17909 22325-22327 , denotes ,
T17910 22327-22330 PRP$ denotes our
T17912 22331-22338 NN denotes control
T17911 22339-22346 NNS denotes strains
T17913 22347-22351 VBD denotes were
T17908 22352-22361 VBN denotes developed
T17914 22362-22366 IN denotes from
T17915 22367-22371 NNS denotes mice
T17916 22372-22382 VBG denotes undergoing
T17917 22383-22386 DT denotes the
T17919 22387-22391 JJ denotes same
T17918 22392-22401 NN denotes selection
T17920 22402-22404 IN denotes as
T17921 22405-22408 DT denotes all
T17922 22409-22411 IN denotes of
T17923 22412-22415 DT denotes the
T17925 22416-22421 JJ denotes other
T17924 22422-22431 NNS denotes congenics
T17926 22431-22432 . denotes .
T17927 22432-22562 sentence denotes Therefore, it is possible that any unwanted QTL or mutations arising during congenic construction are shared between all strains.
T17928 22433-22442 RB denotes Therefore
T17930 22442-22444 , denotes ,
T17931 22444-22446 PRP denotes it
T17929 22447-22449 VBZ denotes is
T17932 22450-22458 JJ denotes possible
T17933 22459-22463 IN denotes that
T17935 22464-22467 DT denotes any
T17937 22468-22476 JJ denotes unwanted
T17936 22477-22480 NN denotes QTL
T17938 22481-22483 CC denotes or
T17939 22484-22493 NNS denotes mutations
T17940 22494-22501 VBG denotes arising
T17941 22502-22508 IN denotes during
T17942 22509-22517 JJ denotes congenic
T17943 22518-22530 NN denotes construction
T17944 22531-22534 VBP denotes are
T17934 22535-22541 VBN denotes shared
T17945 22542-22549 IN denotes between
T17946 22550-22553 DT denotes all
T17947 22554-22561 NNS denotes strains
T17948 22561-22562 . denotes .
T17949 22562-22681 sentence denotes More importantly, we have knowledge of all large previously detected growth and obesity QTL in the current cross [24].
T17950 22563-22567 RBR denotes More
T17951 22568-22579 RB denotes importantly
T17953 22579-22581 , denotes ,
T17954 22581-22583 PRP denotes we
T17952 22584-22588 VBP denotes have
T17955 22589-22598 NN denotes knowledge
T17956 22599-22601 IN denotes of
T17957 22602-22605 DT denotes all
T17959 22606-22611 JJ denotes large
T17960 22612-22622 RB denotes previously
T17961 22623-22631 VBN denotes detected
T17962 22632-22638 NN denotes growth
T17963 22639-22642 CC denotes and
T17964 22643-22650 NN denotes obesity
T17958 22651-22654 NN denotes QTL
T17965 22655-22657 IN denotes in
T17966 22658-22661 DT denotes the
T17968 22662-22669 JJ denotes current
T17967 22670-22675 NN denotes cross
T17969 22676-22677 -LRB- denotes [
T17970 22677-22679 CD denotes 24
T17971 22679-22680 -RRB- denotes ]
T17972 22680-22681 . denotes .
T17973 22681-22880 sentence denotes Using this information we increased the density of markers in each QTL region (MMU1, 2, 5, 8, 9, 11 and 17; Table 1 and Additional File 1), ensuring the absence of CAST alleles at each of these QTL.
T17974 22682-22687 VBG denotes Using
T17976 22688-22692 DT denotes this
T17977 22693-22704 NN denotes information
T17978 22705-22707 PRP denotes we
T17975 22708-22717 VBD denotes increased
T17979 22718-22721 DT denotes the
T17980 22722-22729 NN denotes density
T17981 22730-22732 IN denotes of
T17982 22733-22740 NNS denotes markers
T17983 22741-22743 IN denotes in
T17984 22744-22748 DT denotes each
T17986 22749-22752 NN denotes QTL
T17985 22753-22759 NN denotes region
T17987 22760-22761 -LRB- denotes (
T17989 22761-22764 NN denotes MMU
T17990 22764-22765 CD denotes 1
T17991 22765-22767 , denotes ,
T17992 22767-22768 CD denotes 2
T17993 22768-22770 , denotes ,
T17994 22770-22771 CD denotes 5
T17995 22771-22773 , denotes ,
T17996 22773-22774 CD denotes 8
T17997 22774-22776 , denotes ,
T17998 22776-22777 CD denotes 9
T17999 22777-22779 , denotes ,
T18000 22779-22781 CD denotes 11
T18001 22782-22785 CC denotes and
T18002 22786-22788 CD denotes 17
T18003 22788-22789 : denotes ;
T17988 22790-22795 NN denotes Table
T18004 22796-22797 CD denotes 1
T18005 22798-22801 CC denotes and
T18006 22802-22812 JJ denotes Additional
T18007 22813-22817 NN denotes File
T18008 22818-22819 CD denotes 1
T18009 22819-22820 -RRB- denotes )
T18010 22820-22822 , denotes ,
T18011 22822-22830 VBG denotes ensuring
T18012 22831-22834 DT denotes the
T18013 22835-22842 NN denotes absence
T18014 22843-22845 IN denotes of
T18015 22846-22850 NN denotes CAST
T18016 22851-22858 NNS denotes alleles
T18017 22859-22861 IN denotes at
T18018 22862-22866 DT denotes each
T18019 22867-22869 IN denotes of
T18020 22870-22875 DT denotes these
T18021 22876-22879 NN denotes QTL
T18022 22879-22880 . denotes .
T18023 22880-23039 sentence denotes This approach, termed "QTL-Marker-Assisted Counter Selection" or QMACS, has been previously used to characterize QTL for hypnotic sensitivity to ethanol [31].
T18024 22881-22885 DT denotes This
T18025 22886-22894 NN denotes approach
T18027 22894-22896 , denotes ,
T18028 22896-22902 VBN denotes termed
T18029 22903-22904 `` denotes "
T18030 22904-22907 NN denotes QTL
T18032 22907-22908 HYPH denotes -
T18031 22908-22914 NN denotes Marker
T18034 22914-22915 HYPH denotes -
T18033 22915-22923 VBN denotes Assisted
T18036 22924-22931 NN denotes Counter
T18035 22932-22941 NN denotes Selection
T18037 22941-22942 '' denotes "
T18038 22943-22945 CC denotes or
T18039 22946-22951 NN denotes QMACS
T18040 22951-22953 , denotes ,
T18041 22953-22956 VBZ denotes has
T18042 22957-22961 VBN denotes been
T18043 22962-22972 RB denotes previously
T18026 22973-22977 VBN denotes used
T18044 22978-22980 TO denotes to
T18045 22981-22993 VB denotes characterize
T18046 22994-22997 NN denotes QTL
T18047 22998-23001 IN denotes for
T18048 23002-23010 JJ denotes hypnotic
T18049 23011-23022 NN denotes sensitivity
T18050 23023-23025 IN denotes to
T18051 23026-23033 NN denotes ethanol
T18052 23034-23035 -LRB- denotes [
T18053 23035-23037 CD denotes 31
T18054 23037-23038 -RRB- denotes ]
T18055 23038-23039 . denotes .
T18056 23039-23117 sentence denotes In that study, only markers flanking QTL were typed, not genome-wide markers.
T18057 23040-23042 IN denotes In
T18059 23043-23047 DT denotes that
T18060 23048-23053 NN denotes study
T18061 23053-23055 , denotes ,
T18062 23055-23059 RB denotes only
T18063 23060-23067 NNS denotes markers
T18064 23068-23076 VBG denotes flanking
T18065 23077-23080 NN denotes QTL
T18066 23081-23085 VBD denotes were
T18058 23086-23091 VBN denotes typed
T18067 23091-23093 , denotes ,
T18068 23093-23096 CC denotes not
T18070 23097-23103 NN denotes genome
T18072 23103-23104 HYPH denotes -
T18071 23104-23108 JJ denotes wide
T18069 23109-23116 NNS denotes markers
T18073 23116-23117 . denotes .
T18074 23117-23322 sentence denotes In contrast, we selected not only against known QTL, we also screened for genome wide heterozygosity increasing the probability that effects observed are due to genetic variation within each donor region.
T18075 23118-23120 IN denotes In
T18077 23121-23129 NN denotes contrast
T18078 23129-23131 , denotes ,
T18079 23131-23133 PRP denotes we
T18080 23134-23142 VBD denotes selected
T18081 23143-23146 RB denotes not
T18082 23147-23151 RB denotes only
T18083 23152-23159 IN denotes against
T18084 23160-23165 VBN denotes known
T18085 23166-23169 NN denotes QTL
T18086 23169-23171 , denotes ,
T18087 23171-23173 PRP denotes we
T18088 23174-23178 RB denotes also
T18076 23179-23187 VBD denotes screened
T18089 23188-23191 IN denotes for
T18090 23192-23198 NN denotes genome
T18091 23199-23203 JJ denotes wide
T18092 23204-23218 NN denotes heterozygosity
T18093 23219-23229 VBG denotes increasing
T18094 23230-23233 DT denotes the
T18095 23234-23245 NN denotes probability
T18096 23246-23250 IN denotes that
T18098 23251-23258 NNS denotes effects
T18099 23259-23267 VBN denotes observed
T18097 23268-23271 VBP denotes are
T18100 23272-23275 IN denotes due
T18101 23276-23278 IN denotes to
T18102 23279-23286 JJ denotes genetic
T18103 23287-23296 NN denotes variation
T18104 23297-23303 IN denotes within
T18105 23304-23308 DT denotes each
T18107 23309-23314 NN denotes donor
T18106 23315-23321 NN denotes region
T18108 23321-23322 . denotes .
T18109 23322-23573 sentence denotes Although great effort was put forth to eliminate non-donor region direct genetic effects, other factors such as maternal genotype (maternal genotype for each congenic versus control dams differed) and environmental effects could confound our results.
T18110 23323-23331 IN denotes Although
T18112 23332-23337 JJ denotes great
T18113 23338-23344 NN denotes effort
T18114 23345-23348 VBD denotes was
T18111 23349-23352 VBN denotes put
T18116 23353-23358 RP denotes forth
T18117 23359-23361 TO denotes to
T18118 23362-23371 VB denotes eliminate
T18119 23372-23381 JJ denotes non-donor
T18120 23382-23388 NN denotes region
T18122 23389-23395 JJ denotes direct
T18123 23396-23403 JJ denotes genetic
T18121 23404-23411 NNS denotes effects
T18124 23411-23413 , denotes ,
T18125 23413-23418 JJ denotes other
T18126 23419-23426 NNS denotes factors
T18127 23427-23431 JJ denotes such
T18128 23432-23434 IN denotes as
T18129 23435-23443 JJ denotes maternal
T18130 23444-23452 NN denotes genotype
T18131 23453-23454 -LRB- denotes (
T18133 23454-23462 JJ denotes maternal
T18134 23463-23471 NN denotes genotype
T18135 23472-23475 IN denotes for
T18136 23476-23480 DT denotes each
T18137 23481-23489 JJ denotes congenic
T18138 23490-23496 CC denotes versus
T18139 23497-23504 NN denotes control
T18140 23505-23509 NNS denotes dams
T18132 23510-23518 VBD denotes differed
T18141 23518-23519 -RRB- denotes )
T18142 23520-23523 CC denotes and
T18143 23524-23537 JJ denotes environmental
T18144 23538-23545 NNS denotes effects
T18145 23546-23551 MD denotes could
T18115 23552-23560 VB denotes confound
T18146 23561-23564 PRP$ denotes our
T18147 23565-23572 NNS denotes results
T18148 23572-23573 . denotes .
T18149 23573-23742 sentence denotes Maternal genotype effects on growth and obesity have been observed in a number of mouse crosses [8,32-35] and their existence in the current cross cannot be discounted.
T18150 23574-23582 JJ denotes Maternal
T18151 23583-23591 NN denotes genotype
T18152 23592-23599 NNS denotes effects
T18154 23600-23602 IN denotes on
T18155 23603-23609 NN denotes growth
T18156 23610-23613 CC denotes and
T18157 23614-23621 NN denotes obesity
T18158 23622-23626 VBP denotes have
T18159 23627-23631 VBN denotes been
T18153 23632-23640 VBN denotes observed
T18160 23641-23643 IN denotes in
T18161 23644-23645 DT denotes a
T18162 23646-23652 NN denotes number
T18163 23653-23655 IN denotes of
T18164 23656-23661 NN denotes mouse
T18165 23662-23669 NNS denotes crosses
T18166 23670-23671 -LRB- denotes [
T18167 23671-23672 CD denotes 8
T18168 23672-23673 , denotes ,
T18169 23673-23675 CD denotes 32
T18170 23675-23676 SYM denotes -
T18171 23676-23678 CD denotes 35
T18172 23678-23679 -RRB- denotes ]
T18173 23680-23683 CC denotes and
T18174 23684-23689 PRP$ denotes their
T18175 23690-23699 NN denotes existence
T18177 23700-23702 IN denotes in
T18178 23703-23706 DT denotes the
T18180 23707-23714 JJ denotes current
T18179 23715-23720 NN denotes cross
T18181 23721-23724 MD denotes can
T18182 23724-23727 RB denotes not
T18183 23728-23730 VB denotes be
T18176 23731-23741 VBN denotes discounted
T18184 23741-23742 . denotes .
T18185 23742-23871 sentence denotes However, our congenics provide the ideal foundation genomic resource to test for the influence of any of these possible effects.
T18186 23743-23750 RB denotes However
T18188 23750-23752 , denotes ,
T18189 23752-23755 PRP$ denotes our
T18190 23756-23765 NNS denotes congenics
T18187 23766-23773 VBP denotes provide
T18191 23774-23777 DT denotes the
T18193 23778-23783 JJ denotes ideal
T18194 23784-23794 NN denotes foundation
T18195 23795-23802 JJ denotes genomic
T18192 23803-23811 NN denotes resource
T18196 23812-23814 TO denotes to
T18197 23815-23819 VB denotes test
T18198 23820-23823 IN denotes for
T18199 23824-23827 DT denotes the
T18200 23828-23837 NN denotes influence
T18201 23838-23840 IN denotes of
T18202 23841-23844 DT denotes any
T18203 23845-23847 IN denotes of
T18204 23848-23853 DT denotes these
T18206 23854-23862 JJ denotes possible
T18205 23863-23870 NNS denotes effects
T18207 23870-23871 . denotes .
T18208 23871-24060 sentence denotes Future fine mapping experiments can be designed to randomize the influences of any contaminating donor alleles and environmental differences, as well as test for maternal genotype effects.
T18209 23872-23878 JJ denotes Future
T18211 23879-23883 JJ denotes fine
T18212 23884-23891 NN denotes mapping
T18210 23892-23903 NNS denotes experiments
T18214 23904-23907 MD denotes can
T18215 23908-23910 VB denotes be
T18213 23911-23919 VBN denotes designed
T18216 23920-23922 TO denotes to
T18217 23923-23932 VB denotes randomize
T18218 23933-23936 DT denotes the
T18219 23937-23947 NNS denotes influences
T18220 23948-23950 IN denotes of
T18221 23951-23954 DT denotes any
T18223 23955-23968 VBG denotes contaminating
T18224 23969-23974 NN denotes donor
T18222 23975-23982 NNS denotes alleles
T18225 23983-23986 CC denotes and
T18226 23987-24000 JJ denotes environmental
T18227 24001-24012 NNS denotes differences
T18228 24012-24014 , denotes ,
T18229 24014-24016 RB denotes as
T18231 24017-24021 RB denotes well
T18230 24022-24024 IN denotes as
T18232 24025-24029 VB denotes test
T18233 24030-24033 IN denotes for
T18234 24034-24042 JJ denotes maternal
T18235 24043-24051 NN denotes genotype
T18236 24052-24059 NNS denotes effects
T18237 24059-24060 . denotes .
T18238 24060-24106 sentence denotes MMU2 is a hotspot for growth and obesity QTL.
T18239 24061-24065 NN denotes MMU2
T18240 24066-24068 VBZ denotes is
T18241 24069-24070 DT denotes a
T18242 24071-24078 NN denotes hotspot
T18243 24079-24082 IN denotes for
T18244 24083-24089 NN denotes growth
T18246 24090-24093 CC denotes and
T18247 24094-24101 NN denotes obesity
T18245 24102-24105 NN denotes QTL
T18248 24105-24106 . denotes .
T18249 24106-24169 sentence denotes Over 30 QTL have been identified in various experiments [1,2].
T18250 24107-24111 IN denotes Over
T18251 24112-24114 CD denotes 30
T18252 24115-24118 NN denotes QTL
T18254 24119-24123 VBP denotes have
T18255 24124-24128 VBN denotes been
T18253 24129-24139 VBN denotes identified
T18256 24140-24142 IN denotes in
T18257 24143-24150 JJ denotes various
T18258 24151-24162 NNS denotes experiments
T18259 24163-24164 -LRB- denotes [
T18261 24164-24165 CD denotes 1
T18262 24165-24166 , denotes ,
T18260 24166-24167 CD denotes 2
T18263 24167-24168 -RRB- denotes ]
T18264 24168-24169 . denotes .
T18265 24169-24288 sentence denotes Several previously reported or novel MMU2 QTL have been isolated and characterized using congenic strains [7,9-11,36].
T18266 24170-24177 JJ denotes Several
T18268 24178-24188 RB denotes previously
T18269 24189-24197 VBN denotes reported
T18270 24198-24200 CC denotes or
T18271 24201-24206 JJ denotes novel
T18272 24207-24211 NN denotes MMU2
T18267 24212-24215 NN denotes QTL
T18274 24216-24220 VBP denotes have
T18275 24221-24225 VBN denotes been
T18273 24226-24234 VBN denotes isolated
T18276 24235-24238 CC denotes and
T18277 24239-24252 VBN denotes characterized
T18278 24253-24258 VBG denotes using
T18279 24259-24267 JJ denotes congenic
T18280 24268-24275 NNS denotes strains
T18281 24276-24277 -LRB- denotes [
T18282 24277-24278 CD denotes 7
T18283 24278-24279 , denotes ,
T18284 24279-24280 CD denotes 9
T18285 24280-24281 SYM denotes -
T18286 24281-24283 CD denotes 11
T18287 24283-24284 , denotes ,
T18288 24284-24286 CD denotes 36
T18289 24286-24287 -RRB- denotes ]
T18290 24287-24288 . denotes .
T18291 24288-24411 sentence denotes Our findings are no different and indicate that MMU2 is highly complex with regards to genes affecting growth and obesity.
T18292 24289-24292 PRP$ denotes Our
T18293 24293-24301 NNS denotes findings
T18294 24302-24305 VBP denotes are
T18295 24306-24308 DT denotes no
T18296 24309-24318 JJ denotes different
T18297 24319-24322 CC denotes and
T18298 24323-24331 VBP denotes indicate
T18299 24332-24336 IN denotes that
T18301 24337-24341 NN denotes MMU2
T18300 24342-24344 VBZ denotes is
T18302 24345-24351 RB denotes highly
T18303 24352-24359 JJ denotes complex
T18304 24360-24364 IN denotes with
T18305 24365-24372 NNS denotes regards
T18306 24373-24375 IN denotes to
T18307 24376-24381 NNS denotes genes
T18308 24382-24391 VBG denotes affecting
T18309 24392-24398 NN denotes growth
T18310 24399-24402 CC denotes and
T18311 24403-24410 NN denotes obesity
T18312 24410-24411 . denotes .
T18313 24411-24533 sentence denotes The overlapping nature of our MMU2 strains allowed us to parse the chromosome into five regions (Regions I–V) (Figure 2).
T18314 24412-24415 DT denotes The
T18316 24416-24427 VBG denotes overlapping
T18315 24428-24434 NN denotes nature
T18318 24435-24437 IN denotes of
T18319 24438-24441 PRP$ denotes our
T18321 24442-24446 NN denotes MMU2
T18320 24447-24454 NNS denotes strains
T18317 24455-24462 VBD denotes allowed
T18322 24463-24465 PRP denotes us
T18324 24466-24468 TO denotes to
T18323 24469-24474 VB denotes parse
T18325 24475-24478 DT denotes the
T18326 24479-24489 NN denotes chromosome
T18327 24490-24494 IN denotes into
T18328 24495-24499 CD denotes five
T18329 24500-24507 NNS denotes regions
T18330 24508-24509 -LRB- denotes (
T18331 24509-24516 NNS denotes Regions
T18332 24517-24518 CD denotes I
T18333 24518-24519 SYM denotes –
T18334 24519-24520 CD denotes V
T18335 24520-24521 -RRB- denotes )
T18336 24522-24523 -LRB- denotes (
T18337 24523-24529 NN denotes Figure
T18338 24530-24531 CD denotes 2
T18339 24531-24532 -RRB- denotes )
T18340 24532-24533 . denotes .
T18341 24533-24623 sentence denotes The data support the presence of at least one QTL in each of the five regions (Figure 2).
T18342 24534-24537 DT denotes The
T18343 24538-24542 NNS denotes data
T18344 24543-24550 VBP denotes support
T18345 24551-24554 DT denotes the
T18346 24555-24563 NN denotes presence
T18347 24564-24566 IN denotes of
T18348 24567-24569 RB denotes at
T18350 24570-24575 RBS denotes least
T18349 24576-24579 CD denotes one
T18351 24580-24583 NN denotes QTL
T18352 24584-24586 IN denotes in
T18353 24587-24591 DT denotes each
T18354 24592-24594 IN denotes of
T18355 24595-24598 DT denotes the
T18357 24599-24603 CD denotes five
T18356 24604-24611 NNS denotes regions
T18358 24612-24613 -LRB- denotes (
T18359 24613-24619 NN denotes Figure
T18360 24620-24621 CD denotes 2
T18361 24621-24622 -RRB- denotes )
T18362 24622-24623 . denotes .
T18363 24623-24717 sentence denotes Each of the five pleiotropically impact both growth and obesity, although to varying degrees.
T18364 24624-24628 DT denotes Each
T18366 24629-24631 IN denotes of
T18367 24632-24635 DT denotes the
T18368 24636-24640 CD denotes five
T18369 24641-24656 RB denotes pleiotropically
T18365 24657-24663 VBP denotes impact
T18370 24664-24668 CC denotes both
T18371 24669-24675 NN denotes growth
T18372 24676-24679 CC denotes and
T18373 24680-24687 NN denotes obesity
T18374 24687-24689 , denotes ,
T18375 24689-24697 IN denotes although
T18376 24698-24700 IN denotes to
T18377 24701-24708 VBG denotes varying
T18378 24709-24716 NNS denotes degrees
T18379 24716-24717 . denotes .
T18380 24717-24892 sentence denotes In addition to the large number of MMU2 QTL, the presence of hg adds complexity by either eliciting interactions with the same QTL or by inducing the expression of novel QTL.
T18381 24718-24720 IN denotes In
T18383 24721-24729 NN denotes addition
T18384 24730-24732 IN denotes to
T18385 24733-24736 DT denotes the
T18387 24737-24742 JJ denotes large
T18386 24743-24749 NN denotes number
T18388 24750-24752 IN denotes of
T18389 24753-24757 NN denotes MMU2
T18390 24758-24761 NN denotes QTL
T18391 24761-24763 , denotes ,
T18392 24763-24766 DT denotes the
T18393 24767-24775 NN denotes presence
T18394 24776-24778 IN denotes of
T18395 24779-24781 NN denotes hg
T18382 24782-24786 VBZ denotes adds
T18396 24787-24797 NN denotes complexity
T18397 24798-24800 IN denotes by
T18398 24801-24807 CC denotes either
T18399 24808-24817 VBG denotes eliciting
T18400 24818-24830 NNS denotes interactions
T18401 24831-24835 IN denotes with
T18402 24836-24839 DT denotes the
T18404 24840-24844 JJ denotes same
T18403 24845-24848 NN denotes QTL
T18405 24849-24851 CC denotes or
T18406 24852-24854 IN denotes by
T18407 24855-24863 VBG denotes inducing
T18408 24864-24867 DT denotes the
T18409 24868-24878 NN denotes expression
T18410 24879-24881 IN denotes of
T18411 24882-24887 JJ denotes novel
T18412 24888-24891 NN denotes QTL
T18413 24891-24892 . denotes .
T18414 24892-25019 sentence denotes The 2P unique region (Region I) contains an hg modifier with large effects on growth and smaller effects on obesity (Table 3).
T18415 24893-24896 DT denotes The
T18417 24897-24899 NN denotes 2P
T18418 24900-24906 JJ denotes unique
T18416 24907-24913 NN denotes region
T18420 24914-24915 -LRB- denotes (
T18421 24915-24921 NN denotes Region
T18422 24922-24923 CD denotes I
T18423 24923-24924 -RRB- denotes )
T18419 24925-24933 VBZ denotes contains
T18424 24934-24936 DT denotes an
T18426 24937-24939 NN denotes hg
T18425 24940-24948 NN denotes modifier
T18427 24949-24953 IN denotes with
T18428 24954-24959 JJ denotes large
T18429 24960-24967 NNS denotes effects
T18430 24968-24970 IN denotes on
T18431 24971-24977 NN denotes growth
T18432 24978-24981 CC denotes and
T18433 24982-24989 JJR denotes smaller
T18434 24990-24997 NNS denotes effects
T18435 24998-25000 IN denotes on
T18436 25001-25008 NN denotes obesity
T18437 25009-25010 -LRB- denotes (
T18438 25010-25015 NN denotes Table
T18439 25016-25017 CD denotes 3
T18440 25017-25018 -RRB- denotes )
T18441 25018-25019 . denotes .
T18442 25019-25114 sentence denotes In contrast, interactions between 2PM/2M QTL and hg primarily affect fat deposition (Table 3).
T18443 25020-25022 IN denotes In
T18445 25023-25031 NN denotes contrast
T18446 25031-25033 , denotes ,
T18447 25033-25045 NNS denotes interactions
T18448 25046-25053 IN denotes between
T18449 25054-25057 NN denotes 2PM
T18451 25057-25058 HYPH denotes /
T18450 25058-25060 NN denotes 2M
T18452 25061-25064 NN denotes QTL
T18453 25065-25068 CC denotes and
T18454 25069-25071 NN denotes hg
T18455 25072-25081 RB denotes primarily
T18444 25082-25088 VBP denotes affect
T18456 25089-25092 NN denotes fat
T18457 25093-25103 NN denotes deposition
T18458 25104-25105 -LRB- denotes (
T18459 25105-25110 NN denotes Table
T18460 25111-25112 CD denotes 3
T18461 25112-25113 -RRB- denotes )
T18462 25113-25114 . denotes .
T18463 25114-25244 sentence denotes As illustrated in Figure 4 the 2M donor region exhibits strong sex effects on the rate of lipid storage, dependent on background.
T18464 25115-25117 IN denotes As
T18465 25118-25129 VBN denotes illustrated
T18467 25130-25132 IN denotes in
T18468 25133-25139 NN denotes Figure
T18469 25140-25141 CD denotes 4
T18470 25142-25145 DT denotes the
T18472 25146-25148 NN denotes 2M
T18473 25149-25154 NN denotes donor
T18471 25155-25161 NN denotes region
T18466 25162-25170 VBZ denotes exhibits
T18474 25171-25177 JJ denotes strong
T18476 25178-25181 NN denotes sex
T18475 25182-25189 NNS denotes effects
T18477 25190-25192 IN denotes on
T18478 25193-25196 DT denotes the
T18479 25197-25201 NN denotes rate
T18480 25202-25204 IN denotes of
T18481 25205-25210 NN denotes lipid
T18482 25211-25218 NN denotes storage
T18483 25218-25220 , denotes ,
T18484 25220-25229 JJ denotes dependent
T18485 25230-25232 IN denotes on
T18486 25233-25243 NN denotes background
T18487 25243-25244 . denotes .
T18488 25244-25342 sentence denotes In control mice, HGC females have a higher AI than males, while the opposite is seen in B6C mice.
T18489 25245-25247 IN denotes In
T18491 25248-25255 NN denotes control
T18492 25256-25260 NNS denotes mice
T18493 25260-25262 , denotes ,
T18494 25262-25265 NN denotes HGC
T18495 25266-25273 NNS denotes females
T18490 25274-25278 VBP denotes have
T18496 25279-25280 DT denotes a
T18498 25281-25287 JJR denotes higher
T18497 25288-25290 NN denotes AI
T18499 25291-25295 IN denotes than
T18500 25296-25301 NNS denotes males
T18501 25301-25303 , denotes ,
T18502 25303-25308 IN denotes while
T18504 25309-25312 DT denotes the
T18505 25313-25321 NN denotes opposite
T18506 25322-25324 VBZ denotes is
T18503 25325-25329 VBN denotes seen
T18507 25330-25332 IN denotes in
T18508 25333-25336 NN denotes B6C
T18509 25337-25341 NNS denotes mice
T18510 25341-25342 . denotes .
T18511 25342-25448 sentence denotes Interestingly, the 2M hg modifier QTL abolished the hg induced sexual dimorphism in adiposity (Figure 4).
T18512 25343-25356 RB denotes Interestingly
T18514 25356-25358 , denotes ,
T18515 25358-25361 DT denotes the
T18517 25362-25364 NN denotes 2M
T18518 25365-25367 NN denotes hg
T18519 25368-25376 NN denotes modifier
T18516 25377-25380 NN denotes QTL
T18513 25381-25390 VBD denotes abolished
T18520 25391-25394 DT denotes the
T18522 25395-25397 NN denotes hg
T18523 25398-25405 VBN denotes induced
T18524 25406-25412 JJ denotes sexual
T18521 25413-25423 NN denotes dimorphism
T18525 25424-25426 IN denotes in
T18526 25427-25436 NN denotes adiposity
T18527 25437-25438 -LRB- denotes (
T18528 25438-25444 NN denotes Figure
T18529 25445-25446 CD denotes 4
T18530 25446-25447 -RRB- denotes )
T18531 25447-25448 . denotes .
T18532 25448-25613 sentence denotes Although these results provide insight into the nature of hg modifier QTL, it should be noted, that the actual number and precise location of loci is still unclear.
T18533 25449-25457 IN denotes Although
T18535 25458-25463 DT denotes these
T18536 25464-25471 NNS denotes results
T18534 25472-25479 VBP denotes provide
T18538 25480-25487 NN denotes insight
T18539 25488-25492 IN denotes into
T18540 25493-25496 DT denotes the
T18541 25497-25503 NN denotes nature
T18542 25504-25506 IN denotes of
T18543 25507-25509 NN denotes hg
T18544 25510-25518 NN denotes modifier
T18545 25519-25522 NN denotes QTL
T18546 25522-25524 , denotes ,
T18547 25524-25526 PRP denotes it
T18548 25527-25533 MD denotes should
T18549 25534-25536 VB denotes be
T18537 25537-25542 VBN denotes noted
T18550 25542-25544 , denotes ,
T18551 25544-25548 IN denotes that
T18553 25549-25552 DT denotes the
T18555 25553-25559 JJ denotes actual
T18554 25560-25566 NN denotes number
T18556 25567-25570 CC denotes and
T18557 25571-25578 JJ denotes precise
T18558 25579-25587 NN denotes location
T18559 25588-25590 IN denotes of
T18560 25591-25595 NNS denotes loci
T18552 25596-25598 VBZ denotes is
T18561 25599-25604 RB denotes still
T18562 25605-25612 JJ denotes unclear
T18563 25612-25613 . denotes .
T18564 25613-25703 sentence denotes In addition to MMU2, three other congenics (HG9, HG11 and HG17) captured hg modifier QTL.
T18565 25614-25616 IN denotes In
T18567 25617-25625 NN denotes addition
T18568 25626-25628 IN denotes to
T18569 25629-25633 NN denotes MMU2
T18570 25633-25635 , denotes ,
T18571 25635-25640 CD denotes three
T18573 25641-25646 JJ denotes other
T18572 25647-25656 NNS denotes congenics
T18574 25657-25658 -LRB- denotes (
T18575 25658-25661 NN denotes HG9
T18576 25661-25663 , denotes ,
T18577 25663-25667 NN denotes HG11
T18578 25668-25671 CC denotes and
T18579 25672-25676 NN denotes HG17
T18580 25676-25677 -RRB- denotes )
T18566 25678-25686 VBD denotes captured
T18581 25687-25689 NN denotes hg
T18582 25690-25698 NN denotes modifier
T18583 25699-25702 NN denotes QTL
T18584 25702-25703 . denotes .
T18585 25703-25805 sentence denotes In classical terms, they are QTL which modify the expressivity of growth and obesity in HG mice [18].
T18586 25704-25706 IN denotes In
T18588 25707-25716 JJ denotes classical
T18589 25717-25722 NNS denotes terms
T18590 25722-25724 , denotes ,
T18591 25724-25728 PRP denotes they
T18587 25729-25732 VBP denotes are
T18592 25733-25736 NN denotes QTL
T18593 25737-25742 WDT denotes which
T18594 25743-25749 VBP denotes modify
T18595 25750-25753 DT denotes the
T18596 25754-25766 NN denotes expressivity
T18597 25767-25769 IN denotes of
T18598 25770-25776 NN denotes growth
T18599 25777-25780 CC denotes and
T18600 25781-25788 NN denotes obesity
T18601 25789-25791 IN denotes in
T18602 25792-25794 NN denotes HG
T18603 25795-25799 NNS denotes mice
T18604 25800-25801 -LRB- denotes [
T18605 25801-25803 CD denotes 18
T18606 25803-25804 -RRB- denotes ]
T18607 25804-25805 . denotes .
T18608 25805-25890 sentence denotes These QTL are novel since they represent epistasis between hg and the modifier gene.
T18609 25806-25811 DT denotes These
T18610 25812-25815 NN denotes QTL
T18611 25816-25819 VBP denotes are
T18612 25820-25825 JJ denotes novel
T18613 25826-25831 IN denotes since
T18615 25832-25836 PRP denotes they
T18614 25837-25846 VBP denotes represent
T18616 25847-25856 NN denotes epistasis
T18617 25857-25864 IN denotes between
T18618 25865-25867 NN denotes hg
T18619 25868-25871 CC denotes and
T18620 25872-25875 DT denotes the
T18622 25876-25884 NN denotes modifier
T18621 25885-25889 NN denotes gene
T18623 25889-25890 . denotes .
T18624 25890-25983 sentence denotes QTL-hg epistasis implies that Socs2 and the hg modifiers are in the same biological pathway.
T18625 25891-25894 NN denotes QTL
T18627 25894-25895 HYPH denotes -
T18626 25895-25897 NN denotes hg
T18628 25898-25907 NN denotes epistasis
T18629 25908-25915 VBZ denotes implies
T18630 25916-25920 IN denotes that
T18632 25921-25926 NN denotes Socs2
T18633 25927-25930 CC denotes and
T18634 25931-25934 DT denotes the
T18636 25935-25937 NN denotes hg
T18635 25938-25947 NNS denotes modifiers
T18631 25948-25951 VBP denotes are
T18637 25952-25954 IN denotes in
T18638 25955-25958 DT denotes the
T18640 25959-25963 JJ denotes same
T18641 25964-25974 JJ denotes biological
T18639 25975-25982 NN denotes pathway
T18642 25982-25983 . denotes .
T18643 25983-26125 sentence denotes Therefore, these QTL are likely due to polymorphism in genes interacting with Gh, responsive to Gh or which in some way modulate Gh function.
T18644 25984-25993 RB denotes Therefore
T18646 25993-25995 , denotes ,
T18647 25995-26000 DT denotes these
T18648 26001-26004 NN denotes QTL
T18645 26005-26008 VBP denotes are
T18649 26009-26015 RB denotes likely
T18650 26016-26019 IN denotes due
T18651 26020-26022 IN denotes to
T18652 26023-26035 NN denotes polymorphism
T18653 26036-26038 IN denotes in
T18654 26039-26044 NNS denotes genes
T18655 26045-26056 VBG denotes interacting
T18656 26057-26061 IN denotes with
T18657 26062-26064 NN denotes Gh
T18658 26064-26066 , denotes ,
T18659 26066-26076 JJ denotes responsive
T18660 26077-26079 IN denotes to
T18661 26080-26082 NN denotes Gh
T18662 26083-26085 CC denotes or
T18663 26086-26091 WDT denotes which
T18665 26092-26094 IN denotes in
T18666 26095-26099 DT denotes some
T18667 26100-26103 NN denotes way
T18664 26104-26112 VBP denotes modulate
T18668 26113-26115 NN denotes Gh
T18669 26116-26124 NN denotes function
T18670 26124-26125 . denotes .
T18671 26125-26227 sentence denotes This information will significantly aid QTL cloning by providing another filter to screen candidates.
T18672 26126-26130 DT denotes This
T18673 26131-26142 NN denotes information
T18675 26143-26147 MD denotes will
T18676 26148-26161 RB denotes significantly
T18674 26162-26165 VB denotes aid
T18677 26166-26169 NN denotes QTL
T18678 26170-26177 NN denotes cloning
T18679 26178-26180 IN denotes by
T18680 26181-26190 VBG denotes providing
T18681 26191-26198 DT denotes another
T18682 26199-26205 NN denotes filter
T18683 26206-26208 TO denotes to
T18684 26209-26215 VB denotes screen
T18685 26216-26226 NNS denotes candidates
T18686 26226-26227 . denotes .
T18687 26227-26398 sentence denotes Cloning these QTL has major implications to improve our understanding of Gh and its regulation of growth and adiposity and in the administration of human Gh therapeutics.
T18688 26228-26235 VBG denotes Cloning
T18690 26236-26241 DT denotes these
T18689 26242-26245 NN denotes QTL
T18691 26246-26249 VBZ denotes has
T18692 26250-26255 JJ denotes major
T18693 26256-26268 NNS denotes implications
T18694 26269-26271 TO denotes to
T18695 26272-26279 VB denotes improve
T18696 26280-26283 PRP$ denotes our
T18697 26284-26297 NN denotes understanding
T18698 26298-26300 IN denotes of
T18699 26301-26303 NN denotes Gh
T18700 26304-26307 CC denotes and
T18701 26308-26311 PRP$ denotes its
T18702 26312-26322 NN denotes regulation
T18703 26323-26325 IN denotes of
T18704 26326-26332 NN denotes growth
T18705 26333-26336 CC denotes and
T18706 26337-26346 NN denotes adiposity
T18707 26347-26350 CC denotes and
T18708 26351-26353 IN denotes in
T18709 26354-26357 DT denotes the
T18710 26358-26372 NN denotes administration
T18711 26373-26375 IN denotes of
T18712 26376-26381 JJ denotes human
T18713 26382-26384 NN denotes Gh
T18714 26385-26397 NNS denotes therapeutics
T18715 26397-26398 . denotes .
T18716 26398-26452 sentence denotes HG1 mice displayed differences only in growth traits.
T18717 26399-26402 NN denotes HG1
T18718 26403-26407 NNS denotes mice
T18719 26408-26417 VBD denotes displayed
T18720 26418-26429 NNS denotes differences
T18721 26430-26434 RB denotes only
T18722 26435-26437 IN denotes in
T18723 26438-26444 NN denotes growth
T18724 26445-26451 NNS denotes traits
T18725 26451-26452 . denotes .
T18726 26452-26691 sentence denotes Originally, Q1Ucd1 had small effects and these results illustrate the power of congenic strain analysis to isolate small effect QTL, although it is likely this QTL represents the lower boundary of detection using only 20–30 congenic mice.
T18727 26453-26463 RB denotes Originally
T18729 26463-26465 , denotes ,
T18730 26465-26471 NN denotes Q1Ucd1
T18728 26472-26475 VBD denotes had
T18731 26476-26481 JJ denotes small
T18732 26482-26489 NNS denotes effects
T18733 26490-26493 CC denotes and
T18734 26494-26499 DT denotes these
T18735 26500-26507 NNS denotes results
T18736 26508-26518 VBP denotes illustrate
T18737 26519-26522 DT denotes the
T18738 26523-26528 NN denotes power
T18739 26529-26531 IN denotes of
T18740 26532-26540 JJ denotes congenic
T18741 26541-26547 NN denotes strain
T18742 26548-26556 NN denotes analysis
T18743 26557-26559 TO denotes to
T18744 26560-26567 VB denotes isolate
T18745 26568-26573 JJ denotes small
T18746 26574-26580 NN denotes effect
T18747 26581-26584 NN denotes QTL
T18748 26584-26586 , denotes ,
T18749 26586-26594 IN denotes although
T18751 26595-26597 PRP denotes it
T18750 26598-26600 VBZ denotes is
T18752 26601-26607 JJ denotes likely
T18753 26608-26612 DT denotes this
T18754 26613-26616 NN denotes QTL
T18755 26617-26627 VBZ denotes represents
T18756 26628-26631 DT denotes the
T18758 26632-26637 JJR denotes lower
T18757 26638-26646 NN denotes boundary
T18759 26647-26649 IN denotes of
T18760 26650-26659 NN denotes detection
T18761 26660-26665 VBG denotes using
T18762 26666-26670 RB denotes only
T18764 26671-26673 CD denotes 20
T18765 26673-26674 SYM denotes –
T18763 26674-26676 CD denotes 30
T18767 26677-26685 JJ denotes congenic
T18766 26686-26690 NNS denotes mice
T18768 26690-26691 . denotes .
T18769 26691-26834 sentence denotes The most notable candidate genes located within the HG1 interval are the signal transducer and activator of transcription 1 (Stat1) and Stat4.
T18770 26692-26695 DT denotes The
T18772 26696-26700 RBS denotes most
T18773 26701-26708 JJ denotes notable
T18774 26709-26718 NN denotes candidate
T18771 26719-26724 NNS denotes genes
T18776 26725-26732 VBN denotes located
T18777 26733-26739 IN denotes within
T18778 26740-26743 DT denotes the
T18780 26744-26747 NN denotes HG1
T18779 26748-26756 NN denotes interval
T18775 26757-26760 VBP denotes are
T18781 26761-26764 DT denotes the
T18783 26765-26771 NN denotes signal
T18782 26772-26782 NN denotes transducer
T18784 26783-26786 CC denotes and
T18785 26787-26796 NN denotes activator
T18786 26797-26799 IN denotes of
T18787 26800-26813 NN denotes transcription
T18788 26814-26815 CD denotes 1
T18789 26816-26817 -LRB- denotes (
T18790 26817-26822 NN denotes Stat1
T18791 26822-26823 -RRB- denotes )
T18792 26824-26827 CC denotes and
T18793 26828-26833 NN denotes Stat4
T18794 26833-26834 . denotes .
T18795 26834-26927 sentence denotes Two of the congenics had major alterations in the deposition of adipose tissue, HG8 and HG9.
T18796 26835-26838 CD denotes Two
T18798 26839-26841 IN denotes of
T18799 26842-26845 DT denotes the
T18800 26846-26855 NNS denotes congenics
T18797 26856-26859 VBD denotes had
T18801 26860-26865 JJ denotes major
T18802 26866-26877 NNS denotes alterations
T18803 26878-26880 IN denotes in
T18804 26881-26884 DT denotes the
T18805 26885-26895 NN denotes deposition
T18806 26896-26898 IN denotes of
T18807 26899-26906 NN denotes adipose
T18808 26907-26913 NN denotes tissue
T18809 26913-26915 , denotes ,
T18810 26915-26918 NN denotes HG8
T18811 26919-26922 CC denotes and
T18812 26923-26926 NN denotes HG9
T18813 26926-26927 . denotes .
T18814 26927-26967 sentence denotes The HG8 donor region promotes leanness.
T18815 26928-26931 DT denotes The
T18817 26932-26935 NN denotes HG8
T18818 26936-26941 NN denotes donor
T18816 26942-26948 NN denotes region
T18819 26949-26957 VBZ denotes promotes
T18820 26958-26966 NN denotes leanness
T18821 26966-26967 . denotes .
T18822 26967-27025 sentence denotes Congenic females displayed a reduction of over 25% in AI.
T18823 26968-26976 JJ denotes Congenic
T18824 26977-26984 NNS denotes females
T18825 26985-26994 VBD denotes displayed
T18826 26995-26996 DT denotes a
T18827 26997-27006 NN denotes reduction
T18828 27007-27009 IN denotes of
T18829 27010-27014 IN denotes over
T18830 27015-27017 CD denotes 25
T18831 27017-27018 NN denotes %
T18832 27019-27021 IN denotes in
T18833 27022-27024 NN denotes AI
T18834 27024-27025 . denotes .
T18835 27025-27078 sentence denotes In contrast, the HG9 strain is an obese mouse model.
T18836 27026-27028 IN denotes In
T18838 27029-27037 NN denotes contrast
T18839 27037-27039 , denotes ,
T18840 27039-27042 DT denotes the
T18842 27043-27046 NN denotes HG9
T18841 27047-27053 NN denotes strain
T18837 27054-27056 VBZ denotes is
T18843 27057-27059 DT denotes an
T18845 27060-27065 JJ denotes obese
T18846 27066-27071 NN denotes mouse
T18844 27072-27077 NN denotes model
T18847 27077-27078 . denotes .
T18848 27078-27121 sentence denotes The strain is quite novel for two reasons.
T18849 27079-27082 DT denotes The
T18850 27083-27089 NN denotes strain
T18851 27090-27092 VBZ denotes is
T18852 27093-27098 RB denotes quite
T18853 27099-27104 JJ denotes novel
T18854 27105-27108 IN denotes for
T18855 27109-27112 CD denotes two
T18856 27113-27120 NNS denotes reasons
T18857 27120-27121 . denotes .
T18858 27121-27212 sentence denotes First, the effect size is large; AI was 57% higher in HG9 females and 30% higher in males.
T18859 27122-27127 RB denotes First
T18861 27127-27129 , denotes ,
T18862 27129-27132 DT denotes the
T18864 27133-27139 NN denotes effect
T18863 27140-27144 NN denotes size
T18865 27145-27147 VBZ denotes is
T18866 27148-27153 JJ denotes large
T18867 27153-27154 : denotes ;
T18868 27155-27157 NN denotes AI
T18860 27158-27161 VBD denotes was
T18869 27162-27164 CD denotes 57
T18870 27164-27165 NN denotes %
T18871 27166-27172 JJR denotes higher
T18872 27173-27175 IN denotes in
T18873 27176-27179 NN denotes HG9
T18874 27180-27187 NNS denotes females
T18875 27188-27191 CC denotes and
T18876 27192-27194 CD denotes 30
T18877 27194-27195 NN denotes %
T18878 27196-27202 JJR denotes higher
T18879 27203-27205 IN denotes in
T18880 27206-27211 NNS denotes males
T18881 27211-27212 . denotes .
T18882 27212-27264 sentence denotes Secondly, it is dependent on hg for its expression.
T18883 27213-27221 RB denotes Secondly
T18885 27221-27223 , denotes ,
T18886 27223-27225 PRP denotes it
T18884 27226-27228 VBZ denotes is
T18887 27229-27238 JJ denotes dependent
T18888 27239-27241 IN denotes on
T18889 27242-27244 NN denotes hg
T18890 27245-27248 IN denotes for
T18891 27249-27252 PRP$ denotes its
T18892 27253-27263 NN denotes expression
T18893 27263-27264 . denotes .
T18894 27264-27452 sentence denotes The HG9 strain represents a major epistasis-based obese mouse model and promises to aid in the understanding of obesity and specifically the modulation of adipose tissue deposition by Gh.
T18895 27265-27268 DT denotes The
T18897 27269-27272 NN denotes HG9
T18896 27273-27279 NN denotes strain
T18898 27280-27290 VBZ denotes represents
T18899 27291-27292 DT denotes a
T18901 27293-27298 JJ denotes major
T18902 27299-27308 NN denotes epistasis
T18904 27308-27309 HYPH denotes -
T18903 27309-27314 VBN denotes based
T18905 27315-27320 JJ denotes obese
T18906 27321-27326 NN denotes mouse
T18900 27327-27332 NN denotes model
T18907 27333-27336 CC denotes and
T18908 27337-27345 VBZ denotes promises
T18909 27346-27348 TO denotes to
T18910 27349-27352 VB denotes aid
T18911 27353-27355 IN denotes in
T18912 27356-27359 DT denotes the
T18913 27360-27373 NN denotes understanding
T18914 27374-27376 IN denotes of
T18915 27377-27384 NN denotes obesity
T18916 27385-27388 CC denotes and
T18917 27389-27401 RB denotes specifically
T18919 27402-27405 DT denotes the
T18918 27406-27416 NN denotes modulation
T18920 27417-27419 IN denotes of
T18921 27420-27427 NN denotes adipose
T18922 27428-27434 NN denotes tissue
T18923 27435-27445 NN denotes deposition
T18924 27446-27448 IN denotes by
T18925 27449-27451 NN denotes Gh
T18926 27451-27452 . denotes .
T18927 27452-27708 sentence denotes Studies are currently underway to identify the causative mutation and to characterize the effects of age and diet on obesity in this strain as well as testing for other physiological consequences such as alterations in food intake and insulin sensitivity.
T18928 27453-27460 NNS denotes Studies
T18929 27461-27464 VBP denotes are
T18930 27465-27474 RB denotes currently
T18931 27475-27483 JJ denotes underway
T18932 27484-27486 TO denotes to
T18933 27487-27495 VB denotes identify
T18934 27496-27499 DT denotes the
T18936 27500-27509 JJ denotes causative
T18935 27510-27518 NN denotes mutation
T18937 27519-27522 CC denotes and
T18938 27523-27525 TO denotes to
T18939 27526-27538 VB denotes characterize
T18940 27539-27542 DT denotes the
T18941 27543-27550 NNS denotes effects
T18942 27551-27553 IN denotes of
T18943 27554-27557 NN denotes age
T18944 27558-27561 CC denotes and
T18945 27562-27566 NN denotes diet
T18946 27567-27569 IN denotes on
T18947 27570-27577 NN denotes obesity
T18948 27578-27580 IN denotes in
T18949 27581-27585 DT denotes this
T18950 27586-27592 NN denotes strain
T18951 27593-27595 RB denotes as
T18953 27596-27600 RB denotes well
T18952 27601-27603 IN denotes as
T18954 27604-27611 NN denotes testing
T18955 27612-27615 IN denotes for
T18956 27616-27621 JJ denotes other
T18958 27622-27635 JJ denotes physiological
T18957 27636-27648 NNS denotes consequences
T18959 27649-27653 JJ denotes such
T18960 27654-27656 IN denotes as
T18961 27657-27668 NNS denotes alterations
T18962 27669-27671 IN denotes in
T18963 27672-27676 NN denotes food
T18964 27677-27683 NN denotes intake
T18965 27684-27687 CC denotes and
T18966 27688-27695 NN denotes insulin
T18967 27696-27707 NN denotes sensitivity
T18968 27707-27708 . denotes .
T18969 27708-27775 sentence denotes The HG11 strain is of particular interest for a number of reasons.
T18970 27709-27712 DT denotes The
T18972 27713-27717 NN denotes HG11
T18971 27718-27724 NN denotes strain
T18973 27725-27727 VBZ denotes is
T18974 27728-27730 IN denotes of
T18975 27731-27741 JJ denotes particular
T18976 27742-27750 NN denotes interest
T18977 27751-27754 IN denotes for
T18978 27755-27756 DT denotes a
T18979 27757-27763 NN denotes number
T18980 27764-27766 IN denotes of
T18981 27767-27774 NNS denotes reasons
T18982 27774-27775 . denotes .
T18983 27775-27877 sentence denotes First, HG11 congenic mice demonstrated significant strain by sex interactions for a number of traits.
T18984 27776-27781 RB denotes First
T18986 27781-27783 , denotes ,
T18987 27783-27787 NN denotes HG11
T18988 27788-27796 JJ denotes congenic
T18989 27797-27801 NNS denotes mice
T18985 27802-27814 VBD denotes demonstrated
T18990 27815-27826 JJ denotes significant
T18992 27827-27833 NN denotes strain
T18993 27834-27836 IN denotes by
T18994 27837-27840 NN denotes sex
T18991 27841-27853 NNS denotes interactions
T18995 27854-27857 IN denotes for
T18996 27858-27859 DT denotes a
T18997 27860-27866 NN denotes number
T18998 27867-27869 IN denotes of
T18999 27870-27876 NNS denotes traits
T19000 27876-27877 . denotes .
T19001 27877-27970 sentence denotes Males were generally larger, faster growing and longer and the converse was seen in females.
T19002 27878-27883 NNS denotes Males
T19003 27884-27888 VBD denotes were
T19004 27889-27898 RB denotes generally
T19005 27899-27905 JJR denotes larger
T19006 27905-27907 , denotes ,
T19007 27907-27913 JJR denotes faster
T19008 27914-27921 VBG denotes growing
T19009 27922-27925 CC denotes and
T19010 27926-27932 JJR denotes longer
T19011 27933-27936 CC denotes and
T19012 27937-27940 DT denotes the
T19013 27941-27949 NN denotes converse
T19015 27950-27953 VBD denotes was
T19014 27954-27958 VBN denotes seen
T19016 27959-27961 IN denotes in
T19017 27962-27969 NNS denotes females
T19018 27969-27970 . denotes .
T19019 27970-28132 sentence denotes The confounding effects of sex are likely the reason for the discrepancies between the congenic and genome scan results, where both sexes were analyzed together.
T19020 27971-27974 DT denotes The
T19022 27975-27986 VBG denotes confounding
T19021 27987-27994 NNS denotes effects
T19024 27995-27997 IN denotes of
T19025 27998-28001 NN denotes sex
T19023 28002-28005 VBP denotes are
T19026 28006-28012 RB denotes likely
T19027 28013-28016 DT denotes the
T19028 28017-28023 NN denotes reason
T19029 28024-28027 IN denotes for
T19030 28028-28031 DT denotes the
T19031 28032-28045 NNS denotes discrepancies
T19032 28046-28053 IN denotes between
T19033 28054-28057 DT denotes the
T19035 28058-28066 JJ denotes congenic
T19037 28067-28070 CC denotes and
T19036 28071-28077 NN denotes genome
T19038 28078-28082 NN denotes scan
T19034 28083-28090 NNS denotes results
T19039 28090-28092 , denotes ,
T19040 28092-28097 WRB denotes where
T19042 28098-28102 DT denotes both
T19043 28103-28108 NNS denotes sexes
T19044 28109-28113 VBD denotes were
T19041 28114-28122 VBN denotes analyzed
T19045 28123-28131 RB denotes together
T19046 28131-28132 . denotes .
T19047 28132-28303 sentence denotes Secondly, Carp2 was found to interact with hg and MMU11 is saturated with genes involved in the central Gh intracellular signaling pathway, such as Gh, Stat5b and Stat5a.
T19048 28133-28141 RB denotes Secondly
T19050 28141-28143 , denotes ,
T19051 28143-28148 NN denotes Carp2
T19052 28149-28152 VBD denotes was
T19049 28153-28158 VBN denotes found
T19053 28159-28161 TO denotes to
T19054 28162-28170 VB denotes interact
T19055 28171-28175 IN denotes with
T19056 28176-28178 NN denotes hg
T19057 28179-28182 CC denotes and
T19058 28183-28188 NN denotes MMU11
T19060 28189-28191 VBZ denotes is
T19059 28192-28201 VBN denotes saturated
T19061 28202-28206 IN denotes with
T19062 28207-28212 NNS denotes genes
T19063 28213-28221 VBN denotes involved
T19064 28222-28224 IN denotes in
T19065 28225-28228 DT denotes the
T19067 28229-28236 JJ denotes central
T19068 28237-28239 NN denotes Gh
T19069 28240-28253 JJ denotes intracellular
T19070 28254-28263 NN denotes signaling
T19066 28264-28271 NN denotes pathway
T19071 28271-28273 , denotes ,
T19072 28273-28277 JJ denotes such
T19073 28278-28280 IN denotes as
T19074 28281-28283 NN denotes Gh
T19075 28283-28285 , denotes ,
T19076 28285-28291 NN denotes Stat5b
T19077 28292-28295 CC denotes and
T19078 28296-28302 NN denotes Stat5a
T19079 28302-28303 . denotes .
T19080 28303-28429 sentence denotes Thirdly, MMU11 growth QTL overlapping HG11 have been identified in a number of crosses using different mouse strains [37-41].
T19081 28304-28311 RB denotes Thirdly
T19083 28311-28313 , denotes ,
T19084 28313-28318 NN denotes MMU11
T19086 28319-28325 NN denotes growth
T19085 28326-28329 NN denotes QTL
T19087 28330-28341 VBG denotes overlapping
T19088 28342-28346 NN denotes HG11
T19089 28347-28351 VBP denotes have
T19090 28352-28356 VBN denotes been
T19082 28357-28367 VBN denotes identified
T19091 28368-28370 IN denotes in
T19092 28371-28372 DT denotes a
T19093 28373-28379 NN denotes number
T19094 28380-28382 IN denotes of
T19095 28383-28390 NNS denotes crosses
T19096 28391-28396 VBG denotes using
T19097 28397-28406 JJ denotes different
T19099 28407-28412 NN denotes mouse
T19098 28413-28420 NNS denotes strains
T19100 28421-28422 -LRB- denotes [
T19101 28422-28424 CD denotes 37
T19102 28424-28425 SYM denotes -
T19103 28425-28427 CD denotes 41
T19104 28427-28428 -RRB- denotes ]
T19105 28428-28429 . denotes .
T19106 28429-28666 sentence denotes Given the well documented sexually dimorphic nature of Gh secretion and Gh induced gene expression [42,43], it is probable that the underlying mutation in the HG11 congenic may reside in a gene enhancing Gh induced sex-specific effects.
T19107 28430-28435 VBN denotes Given
T19109 28436-28439 DT denotes the
T19111 28440-28444 RB denotes well
T19112 28445-28455 VBN denotes documented
T19113 28456-28464 RB denotes sexually
T19114 28465-28474 JJ denotes dimorphic
T19110 28475-28481 NN denotes nature
T19115 28482-28484 IN denotes of
T19116 28485-28487 NN denotes Gh
T19117 28488-28497 NN denotes secretion
T19118 28498-28501 CC denotes and
T19119 28502-28504 NN denotes Gh
T19120 28505-28512 VBN denotes induced
T19122 28513-28517 NN denotes gene
T19121 28518-28528 NN denotes expression
T19123 28529-28530 -LRB- denotes [
T19125 28530-28532 CD denotes 42
T19126 28532-28533 , denotes ,
T19124 28533-28535 CD denotes 43
T19127 28535-28536 -RRB- denotes ]
T19128 28536-28538 , denotes ,
T19129 28538-28540 PRP denotes it
T19108 28541-28543 VBZ denotes is
T19130 28544-28552 JJ denotes probable
T19131 28553-28557 IN denotes that
T19133 28558-28561 DT denotes the
T19135 28562-28572 VBG denotes underlying
T19134 28573-28581 NN denotes mutation
T19136 28582-28584 IN denotes in
T19137 28585-28588 DT denotes the
T19138 28589-28593 NN denotes HG11
T19139 28594-28602 JJ denotes congenic
T19140 28603-28606 MD denotes may
T19132 28607-28613 VB denotes reside
T19141 28614-28616 IN denotes in
T19142 28617-28618 DT denotes a
T19143 28619-28623 NN denotes gene
T19144 28624-28633 VBG denotes enhancing
T19145 28634-28636 NN denotes Gh
T19146 28637-28644 VBN denotes induced
T19148 28645-28648 NN denotes sex
T19150 28648-28649 HYPH denotes -
T19149 28649-28657 JJ denotes specific
T19147 28658-28665 NNS denotes effects
T19151 28665-28666 . denotes .
T19152 28666-28733 sentence denotes The structural Gh gene itself and Stat5b are excellent candidates.
T19153 28667-28670 DT denotes The
T19155 28671-28681 JJ denotes structural
T19156 28682-28684 NN denotes Gh
T19154 28685-28689 NN denotes gene
T19158 28690-28696 PRP denotes itself
T19159 28697-28700 CC denotes and
T19160 28701-28707 NN denotes Stat5b
T19157 28708-28711 VBP denotes are
T19161 28712-28721 JJ denotes excellent
T19162 28722-28732 NNS denotes candidates
T19163 28732-28733 . denotes .
T19164 28733-28889 sentence denotes The potential role of Gh would include polymorphism that alters protein function in the absence of Socs2 or that causes transcriptional deregulation of Gh.
T19165 28734-28737 DT denotes The
T19167 28738-28747 JJ denotes potential
T19166 28748-28752 NN denotes role
T19169 28753-28755 IN denotes of
T19170 28756-28758 NN denotes Gh
T19171 28759-28764 MD denotes would
T19168 28765-28772 VB denotes include
T19172 28773-28785 NN denotes polymorphism
T19173 28786-28790 WDT denotes that
T19174 28791-28797 VBZ denotes alters
T19175 28798-28805 NN denotes protein
T19176 28806-28814 NN denotes function
T19177 28815-28817 IN denotes in
T19178 28818-28821 DT denotes the
T19179 28822-28829 NN denotes absence
T19180 28830-28832 IN denotes of
T19181 28833-28838 NN denotes Socs2
T19182 28839-28841 CC denotes or
T19183 28842-28846 DT denotes that
T19184 28847-28853 VBZ denotes causes
T19185 28854-28869 JJ denotes transcriptional
T19186 28870-28882 NN denotes deregulation
T19187 28883-28885 IN denotes of
T19188 28886-28888 NN denotes Gh
T19189 28888-28889 . denotes .
T19190 28889-29100 sentence denotes Additionally, functional variation in Stat5b may explain the sex-specific phenotypes in HG11 mice since it is the primary transcription factor responsible for Gh induced sex-specific liver gene expression [44].
T19191 28890-28902 RB denotes Additionally
T19193 28902-28904 , denotes ,
T19194 28904-28914 JJ denotes functional
T19195 28915-28924 NN denotes variation
T19196 28925-28927 IN denotes in
T19197 28928-28934 NN denotes Stat5b
T19198 28935-28938 MD denotes may
T19192 28939-28946 VB denotes explain
T19199 28947-28950 DT denotes the
T19201 28951-28954 NN denotes sex
T19203 28954-28955 HYPH denotes -
T19202 28955-28963 JJ denotes specific
T19200 28964-28974 NNS denotes phenotypes
T19204 28975-28977 IN denotes in
T19205 28978-28982 NN denotes HG11
T19206 28983-28987 NNS denotes mice
T19207 28988-28993 IN denotes since
T19209 28994-28996 PRP denotes it
T19208 28997-28999 VBZ denotes is
T19210 29000-29003 DT denotes the
T19212 29004-29011 JJ denotes primary
T19213 29012-29025 NN denotes transcription
T19211 29026-29032 NN denotes factor
T19214 29033-29044 JJ denotes responsible
T19215 29045-29048 IN denotes for
T19216 29049-29051 NN denotes Gh
T19217 29052-29059 VBN denotes induced
T19219 29060-29063 NN denotes sex
T19221 29063-29064 HYPH denotes -
T19220 29064-29072 JJ denotes specific
T19222 29073-29078 NN denotes liver
T19223 29079-29083 NN denotes gene
T19218 29084-29094 NN denotes expression
T19224 29095-29096 -LRB- denotes [
T19225 29096-29098 CD denotes 44
T19226 29098-29099 -RRB- denotes ]
T19227 29099-29100 . denotes .
T19228 29100-29269 sentence denotes Future studies aimed at identifying the HG11 QTG, will certainly include a thorough characterization of Gh and Stat5b sequence and expression patterns in congenic mice.
T19229 29101-29107 JJ denotes Future
T19230 29108-29115 NNS denotes studies
T19232 29116-29121 VBN denotes aimed
T19233 29122-29124 IN denotes at
T19234 29125-29136 VBG denotes identifying
T19235 29137-29140 DT denotes the
T19237 29141-29145 NN denotes HG11
T19236 29146-29149 NN denotes QTG
T19238 29149-29151 , denotes ,
T19239 29151-29155 MD denotes will
T19240 29156-29165 RB denotes certainly
T19231 29166-29173 VB denotes include
T19241 29174-29175 DT denotes a
T19243 29176-29184 JJ denotes thorough
T19242 29185-29201 NN denotes characterization
T19244 29202-29204 IN denotes of
T19245 29205-29207 NN denotes Gh
T19247 29208-29211 CC denotes and
T19248 29212-29218 NN denotes Stat5b
T19249 29219-29227 NN denotes sequence
T19250 29228-29231 CC denotes and
T19251 29232-29242 NN denotes expression
T19246 29243-29251 NNS denotes patterns
T19252 29252-29254 IN denotes in
T19253 29255-29263 JJ denotes congenic
T19254 29264-29268 NNS denotes mice
T19255 29268-29269 . denotes .
T19256 29269-29385 sentence denotes The hg modifier QTL located within the HG17 strain had large effects on growth, body length and carcass components.
T19257 29270-29273 DT denotes The
T19259 29274-29276 NN denotes hg
T19260 29277-29285 NN denotes modifier
T19258 29286-29289 NN denotes QTL
T19262 29290-29297 VBN denotes located
T19263 29298-29304 IN denotes within
T19264 29305-29308 DT denotes the
T19266 29309-29313 NN denotes HG17
T19265 29314-29320 NN denotes strain
T19261 29321-29324 VBD denotes had
T19267 29325-29330 JJ denotes large
T19268 29331-29338 NNS denotes effects
T19269 29339-29341 IN denotes on
T19270 29342-29348 NN denotes growth
T19271 29348-29350 , denotes ,
T19272 29350-29354 NN denotes body
T19273 29355-29361 NN denotes length
T19274 29362-29365 CC denotes and
T19275 29366-29373 NN denotes carcass
T19276 29374-29384 NNS denotes components
T19277 29384-29385 . denotes .
T19278 29385-29454 sentence denotes The most intriguing candidate gene located in the congenic is Sstr5.
T19279 29386-29389 DT denotes The
T19281 29390-29394 RBS denotes most
T19282 29395-29405 JJ denotes intriguing
T19283 29406-29415 NN denotes candidate
T19280 29416-29420 NN denotes gene
T19285 29421-29428 VBN denotes located
T19286 29429-29431 IN denotes in
T19287 29432-29435 DT denotes the
T19288 29436-29444 JJ denotes congenic
T19284 29445-29447 VBZ denotes is
T19289 29448-29453 NN denotes Sstr5
T19290 29453-29454 . denotes .
T19291 29454-29567 sentence denotes Somatostatin is a potent inhibitor of Gh and Sstr5 is one of five receptors which mediate these effects [45,46].
T19292 29455-29467 NN denotes Somatostatin
T19293 29468-29470 VBZ denotes is
T19294 29471-29472 DT denotes a
T19296 29473-29479 JJ denotes potent
T19295 29480-29489 NN denotes inhibitor
T19297 29490-29492 IN denotes of
T19298 29493-29495 NN denotes Gh
T19299 29496-29499 CC denotes and
T19300 29500-29505 NN denotes Sstr5
T19301 29506-29508 VBZ denotes is
T19302 29509-29512 CD denotes one
T19303 29513-29515 IN denotes of
T19304 29516-29520 CD denotes five
T19305 29521-29530 NNS denotes receptors
T19306 29531-29536 WDT denotes which
T19307 29537-29544 VBP denotes mediate
T19308 29545-29550 DT denotes these
T19309 29551-29558 NNS denotes effects
T19310 29559-29560 -LRB- denotes [
T19312 29560-29562 CD denotes 45
T19313 29562-29563 , denotes ,
T19311 29563-29565 CD denotes 46
T19314 29565-29566 -RRB- denotes ]
T19315 29566-29567 . denotes .
T19316 29567-29705 sentence denotes Ubiquitous and pancreatic beta cell specific knockout of Sstr5 leads to alterations in insulin secretion and glucose homeostasis [47,48].
T19317 29568-29578 JJ denotes Ubiquitous
T19319 29579-29582 CC denotes and
T19320 29583-29593 JJ denotes pancreatic
T19322 29594-29598 NN denotes beta
T19321 29599-29603 NN denotes cell
T19323 29604-29612 JJ denotes specific
T19318 29613-29621 NN denotes knockout
T19325 29622-29624 IN denotes of
T19326 29625-29630 NN denotes Sstr5
T19324 29631-29636 VBZ denotes leads
T19327 29637-29639 IN denotes to
T19328 29640-29651 NNS denotes alterations
T19329 29652-29654 IN denotes in
T19330 29655-29662 NN denotes insulin
T19331 29663-29672 NN denotes secretion
T19332 29673-29676 CC denotes and
T19333 29677-29684 NN denotes glucose
T19334 29685-29696 NN denotes homeostasis
T19335 29697-29698 -LRB- denotes [
T19337 29698-29700 CD denotes 47
T19338 29700-29701 , denotes ,
T19336 29701-29703 CD denotes 48
T19339 29703-29704 -RRB- denotes ]
T19340 29704-29705 . denotes .
T19341 29705-29827 sentence denotes We sequenced candidate hg modifier genes to complement the characterization of the speed congenics on MMU2, 9, 11 and 17.
T19342 29706-29708 PRP denotes We
T19343 29709-29718 VBD denotes sequenced
T19344 29719-29728 NN denotes candidate
T19346 29729-29731 NN denotes hg
T19347 29732-29740 NN denotes modifier
T19345 29741-29746 NNS denotes genes
T19348 29747-29749 TO denotes to
T19349 29750-29760 VB denotes complement
T19350 29761-29764 DT denotes the
T19351 29765-29781 NN denotes characterization
T19352 29782-29784 IN denotes of
T19353 29785-29788 DT denotes the
T19355 29789-29794 NN denotes speed
T19354 29795-29804 NNS denotes congenics
T19356 29805-29807 IN denotes on
T19357 29808-29811 NN denotes MMU
T19358 29811-29812 CD denotes 2
T19359 29812-29814 , denotes ,
T19360 29814-29815 CD denotes 9
T19361 29815-29817 , denotes ,
T19362 29817-29819 CD denotes 11
T19363 29820-29823 CC denotes and
T19364 29824-29826 CD denotes 17
T19365 29826-29827 . denotes .
T19366 29827-30024 sentence denotes A limited number of studies have identified variation within CAST coding sequence; so sequencing candidates gave us the opportunity to estimate the SNP frequency in coding sequence relative to B6.
T19367 29828-29829 DT denotes A
T19369 29830-29837 JJ denotes limited
T19368 29838-29844 NN denotes number
T19371 29845-29847 IN denotes of
T19372 29848-29855 NNS denotes studies
T19373 29856-29860 VBP denotes have
T19370 29861-29871 VBN denotes identified
T19374 29872-29881 NN denotes variation
T19375 29882-29888 IN denotes within
T19376 29889-29893 NN denotes CAST
T19378 29894-29900 NN denotes coding
T19377 29901-29909 NN denotes sequence
T19379 29909-29910 : denotes ;
T19380 29911-29913 CC denotes so
T19381 29914-29924 VBG denotes sequencing
T19382 29925-29935 NNS denotes candidates
T19383 29936-29940 VBD denotes gave
T19384 29941-29943 PRP denotes us
T19385 29944-29947 DT denotes the
T19386 29948-29959 NN denotes opportunity
T19387 29960-29962 TO denotes to
T19388 29963-29971 VB denotes estimate
T19389 29972-29975 DT denotes the
T19391 29976-29979 NN denotes SNP
T19390 29980-29989 NN denotes frequency
T19392 29990-29992 IN denotes in
T19393 29993-29999 NN denotes coding
T19394 30000-30008 NN denotes sequence
T19395 30009-30017 JJ denotes relative
T19396 30018-30020 IN denotes to
T19397 30021-30023 NN denotes B6
T19398 30023-30024 . denotes .
T19399 30024-30132 sentence denotes This information will be vital to future fine mapping studies, which will include gene expression analysis.
T19400 30025-30029 DT denotes This
T19401 30030-30041 NN denotes information
T19403 30042-30046 MD denotes will
T19402 30047-30049 VB denotes be
T19404 30050-30055 JJ denotes vital
T19405 30056-30058 IN denotes to
T19406 30059-30065 JJ denotes future
T19408 30066-30070 JJ denotes fine
T19409 30071-30078 NN denotes mapping
T19407 30079-30086 NNS denotes studies
T19410 30086-30088 , denotes ,
T19411 30088-30093 WDT denotes which
T19413 30094-30098 MD denotes will
T19412 30099-30106 VB denotes include
T19414 30107-30111 NN denotes gene
T19415 30112-30122 NN denotes expression
T19416 30123-30131 NN denotes analysis
T19417 30131-30132 . denotes .
T19418 30132-30346 sentence denotes The high SNP frequency (0.312%; 295 SNP in 94.492 kbp) in CAST genes may lead to a higher rate of false positives using DNA microarrays or quantitative real-time PCR assays, most of which are based on B6 sequence.
T19419 30133-30136 DT denotes The
T19421 30137-30141 JJ denotes high
T19422 30142-30145 NN denotes SNP
T19420 30146-30155 NN denotes frequency
T19424 30156-30157 -LRB- denotes (
T19426 30157-30162 CD denotes 0.312
T19427 30162-30163 NN denotes %
T19428 30163-30164 : denotes ;
T19429 30165-30168 CD denotes 295
T19425 30169-30172 NN denotes SNP
T19430 30173-30175 IN denotes in
T19431 30176-30182 CD denotes 94.492
T19432 30183-30186 NN denotes kbp
T19433 30186-30187 -RRB- denotes )
T19434 30188-30190 IN denotes in
T19435 30191-30195 NN denotes CAST
T19436 30196-30201 NNS denotes genes
T19437 30202-30205 MD denotes may
T19423 30206-30210 VB denotes lead
T19438 30211-30213 IN denotes to
T19439 30214-30215 DT denotes a
T19441 30216-30222 JJR denotes higher
T19440 30223-30227 NN denotes rate
T19442 30228-30230 IN denotes of
T19443 30231-30236 JJ denotes false
T19444 30237-30246 NNS denotes positives
T19445 30247-30252 VBG denotes using
T19446 30253-30256 NN denotes DNA
T19447 30257-30268 NNS denotes microarrays
T19448 30269-30271 CC denotes or
T19449 30272-30284 JJ denotes quantitative
T19451 30285-30289 JJ denotes real
T19453 30289-30290 HYPH denotes -
T19452 30290-30294 NN denotes time
T19454 30295-30298 NN denotes PCR
T19450 30299-30305 NNS denotes assays
T19455 30305-30307 , denotes ,
T19456 30307-30311 JJS denotes most
T19458 30312-30314 IN denotes of
T19459 30315-30320 WDT denotes which
T19460 30321-30324 VBP denotes are
T19457 30325-30330 VBN denotes based
T19461 30331-30333 IN denotes on
T19462 30334-30336 NN denotes B6
T19463 30337-30345 NN denotes sequence
T19464 30345-30346 . denotes .
T19465 30346-30577 sentence denotes Therefore, these sequence data can be used to guide the development of gene expression assays to confirm differential expression for candidates and suggests that genes identified by downstream experiments should also be sequenced.
T19466 30347-30356 RB denotes Therefore
T19468 30356-30358 , denotes ,
T19469 30358-30363 DT denotes these
T19471 30364-30372 NN denotes sequence
T19470 30373-30377 NNS denotes data
T19472 30378-30381 MD denotes can
T19473 30382-30384 VB denotes be
T19467 30385-30389 VBN denotes used
T19474 30390-30392 TO denotes to
T19475 30393-30398 VB denotes guide
T19476 30399-30402 DT denotes the
T19477 30403-30414 NN denotes development
T19478 30415-30417 IN denotes of
T19479 30418-30422 NN denotes gene
T19480 30423-30433 NN denotes expression
T19481 30434-30440 NNS denotes assays
T19482 30441-30443 TO denotes to
T19483 30444-30451 VB denotes confirm
T19484 30452-30464 JJ denotes differential
T19485 30465-30475 NN denotes expression
T19486 30476-30479 IN denotes for
T19487 30480-30490 NNS denotes candidates
T19488 30491-30494 CC denotes and
T19489 30495-30503 VBZ denotes suggests
T19490 30504-30508 IN denotes that
T19492 30509-30514 NNS denotes genes
T19493 30515-30525 VBN denotes identified
T19494 30526-30528 IN denotes by
T19495 30529-30539 JJ denotes downstream
T19496 30540-30551 NNS denotes experiments
T19497 30552-30558 MD denotes should
T19498 30559-30563 RB denotes also
T19499 30564-30566 VB denotes be
T19491 30567-30576 VBN denotes sequenced
T19500 30576-30577 . denotes .
T19501 30577-30704 sentence denotes More importantly, sequencing hg modifier candidates allowed us to identify nonsynonomous polymorphism, which may underlie QTL.
T19502 30578-30582 RBR denotes More
T19503 30583-30594 RB denotes importantly
T19505 30594-30596 , denotes ,
T19506 30596-30606 VBG denotes sequencing
T19507 30607-30609 NN denotes hg
T19508 30610-30618 NN denotes modifier
T19509 30619-30629 NNS denotes candidates
T19504 30630-30637 VBD denotes allowed
T19510 30638-30640 PRP denotes us
T19512 30641-30643 TO denotes to
T19511 30644-30652 VB denotes identify
T19513 30653-30666 JJ denotes nonsynonomous
T19514 30667-30679 NN denotes polymorphism
T19515 30679-30681 , denotes ,
T19516 30681-30686 WDT denotes which
T19518 30687-30690 MD denotes may
T19517 30691-30699 VB denotes underlie
T19519 30700-30703 NN denotes QTL
T19520 30703-30704 . denotes .
T19521 30704-30849 sentence denotes SIFT and/or PolyPhen predicted alterations in protein function for 15 of the 56 total nsSNP (27%) in nine of the 44 total genes (20%) (Table 7).
T19522 30705-30709 NNP denotes SIFT
T19524 30710-30713 CC denotes and
T19525 30713-30714 HYPH denotes /
T19526 30714-30716 CC denotes or
T19527 30717-30725 NNP denotes PolyPhen
T19523 30726-30735 VBN denotes predicted
T19528 30736-30747 NNS denotes alterations
T19529 30748-30750 IN denotes in
T19530 30751-30758 NN denotes protein
T19531 30759-30767 NN denotes function
T19532 30768-30771 IN denotes for
T19533 30772-30774 CD denotes 15
T19534 30775-30777 IN denotes of
T19535 30778-30781 DT denotes the
T19537 30782-30784 CD denotes 56
T19538 30785-30790 JJ denotes total
T19536 30791-30796 NN denotes nsSNP
T19539 30797-30798 -LRB- denotes (
T19541 30798-30800 CD denotes 27
T19540 30800-30801 NN denotes %
T19542 30801-30802 -RRB- denotes )
T19543 30803-30805 IN denotes in
T19544 30806-30810 CD denotes nine
T19545 30811-30813 IN denotes of
T19546 30814-30817 DT denotes the
T19548 30818-30820 CD denotes 44
T19549 30821-30826 JJ denotes total
T19547 30827-30832 NNS denotes genes
T19550 30833-30834 -LRB- denotes (
T19552 30834-30836 CD denotes 20
T19551 30836-30837 NN denotes %
T19553 30837-30838 -RRB- denotes )
T19554 30839-30840 -LRB- denotes (
T19555 30840-30845 NN denotes Table
T19556 30846-30847 CD denotes 7
T19557 30847-30848 -RRB- denotes )
T19558 30848-30849 . denotes .
T19559 30849-30991 sentence denotes It has been shown that predicting function based on evolutionary conservation using programs such as SIFT and PolyPhen is very accurate [49].
T19560 30850-30852 PRP denotes It
T19562 30853-30856 VBZ denotes has
T19563 30857-30861 VBN denotes been
T19561 30862-30867 VBN denotes shown
T19564 30868-30872 IN denotes that
T19566 30873-30883 VBG denotes predicting
T19567 30884-30892 NN denotes function
T19568 30893-30898 VBN denotes based
T19569 30899-30901 IN denotes on
T19570 30902-30914 JJ denotes evolutionary
T19571 30915-30927 NN denotes conservation
T19572 30928-30933 VBG denotes using
T19573 30934-30942 NNS denotes programs
T19574 30943-30947 JJ denotes such
T19575 30948-30950 IN denotes as
T19576 30951-30955 NNP denotes SIFT
T19577 30956-30959 CC denotes and
T19578 30960-30968 NNP denotes PolyPhen
T19565 30969-30971 VBZ denotes is
T19579 30972-30976 RB denotes very
T19580 30977-30985 JJ denotes accurate
T19581 30986-30987 -LRB- denotes [
T19582 30987-30989 CD denotes 49
T19583 30989-30990 -RRB- denotes ]
T19584 30990-30991 . denotes .
T19585 30991-31102 sentence denotes Four of the nine genes (Ubr1, Ptpns1, Ubce7ip5 and Mmp9; all of which are on MMU2) are of particular interest.
T19586 30992-30996 CD denotes Four
T19588 30997-30999 IN denotes of
T19589 31000-31003 DT denotes the
T19591 31004-31008 CD denotes nine
T19590 31009-31014 NNS denotes genes
T19592 31015-31016 -LRB- denotes (
T19593 31016-31020 NN denotes Ubr1
T19594 31020-31022 , denotes ,
T19595 31022-31028 NN denotes Ptpns1
T19596 31028-31030 , denotes ,
T19597 31030-31038 NN denotes Ubce7ip5
T19598 31039-31042 CC denotes and
T19599 31043-31047 NN denotes Mmp9
T19600 31047-31048 : denotes ;
T19601 31049-31052 DT denotes all
T19603 31053-31055 IN denotes of
T19604 31056-31061 WDT denotes which
T19602 31062-31065 VBP denotes are
T19605 31066-31068 IN denotes on
T19606 31069-31073 NN denotes MMU2
T19607 31073-31074 -RRB- denotes )
T19587 31075-31078 VBP denotes are
T19608 31079-31081 IN denotes of
T19609 31082-31092 JJ denotes particular
T19610 31093-31101 NN denotes interest
T19611 31101-31102 . denotes .
T19612 31102-31225 sentence denotes It has been suggested the Socs2 may rely on ubiquitination dependent proteasomal degradation to inhibit Gh signaling [23].
T19613 31103-31105 PRP denotes It
T19615 31106-31109 VBZ denotes has
T19616 31110-31114 VBN denotes been
T19614 31115-31124 VBN denotes suggested
T19617 31125-31128 DT denotes the
T19618 31129-31134 NN denotes Socs2
T19620 31135-31138 MD denotes may
T19619 31139-31143 VB denotes rely
T19621 31144-31146 IN denotes on
T19622 31147-31161 NN denotes ubiquitination
T19623 31162-31171 JJ denotes dependent
T19625 31172-31183 JJ denotes proteasomal
T19624 31184-31195 NN denotes degradation
T19626 31196-31198 TO denotes to
T19627 31199-31206 VB denotes inhibit
T19628 31207-31209 NN denotes Gh
T19629 31210-31219 NN denotes signaling
T19630 31220-31221 -LRB- denotes [
T19631 31221-31223 CD denotes 23
T19632 31223-31224 -RRB- denotes ]
T19633 31224-31225 . denotes .
T19634 31225-31399 sentence denotes Ubr1 and Ubce7ip5 are both involved in protein ubiquitination and Ubr1 knockout mice show an 20% decrease in body weight partly due to a reduction in adipose tissue [50,51].
T19635 31226-31230 NN denotes Ubr1
T19637 31231-31234 CC denotes and
T19638 31235-31243 NN denotes Ubce7ip5
T19639 31244-31247 VBP denotes are
T19640 31248-31252 RB denotes both
T19636 31253-31261 VBN denotes involved
T19641 31262-31264 IN denotes in
T19642 31265-31272 NN denotes protein
T19643 31273-31287 NN denotes ubiquitination
T19644 31288-31291 CC denotes and
T19645 31292-31296 NN denotes Ubr1
T19646 31297-31305 NN denotes knockout
T19647 31306-31310 NNS denotes mice
T19648 31311-31315 VBP denotes show
T19649 31316-31318 DT denotes an
T19651 31319-31321 CD denotes 20
T19652 31321-31322 NN denotes %
T19650 31323-31331 NN denotes decrease
T19653 31332-31334 IN denotes in
T19654 31335-31339 NN denotes body
T19655 31340-31346 NN denotes weight
T19656 31347-31353 RB denotes partly
T19657 31354-31357 IN denotes due
T19658 31358-31360 IN denotes to
T19659 31361-31362 DT denotes a
T19660 31363-31372 NN denotes reduction
T19661 31373-31375 IN denotes in
T19662 31376-31383 NN denotes adipose
T19663 31384-31390 NN denotes tissue
T19664 31391-31392 -LRB- denotes [
T19666 31392-31394 CD denotes 50
T19667 31394-31395 , denotes ,
T19665 31395-31397 CD denotes 51
T19668 31397-31398 -RRB- denotes ]
T19669 31398-31399 . denotes .
T19670 31399-31556 sentence denotes Ptpns1 knockout mice displayed a 10% reduction in body weight [52] and Mmp9 knockout mice show a reduction in size and drastically reduced bone length [53].
T19671 31400-31406 NN denotes Ptpns1
T19673 31407-31415 NN denotes knockout
T19672 31416-31420 NNS denotes mice
T19674 31421-31430 VBD denotes displayed
T19675 31431-31432 DT denotes a
T19677 31433-31435 CD denotes 10
T19678 31435-31436 NN denotes %
T19676 31437-31446 NN denotes reduction
T19679 31447-31449 IN denotes in
T19680 31450-31454 NN denotes body
T19681 31455-31461 NN denotes weight
T19682 31462-31463 -LRB- denotes [
T19683 31463-31465 CD denotes 52
T19684 31465-31466 -RRB- denotes ]
T19685 31467-31470 CC denotes and
T19686 31471-31475 NN denotes Mmp9
T19688 31476-31484 NN denotes knockout
T19687 31485-31489 NNS denotes mice
T19689 31490-31494 VBP denotes show
T19690 31495-31496 DT denotes a
T19691 31497-31506 NN denotes reduction
T19692 31507-31509 IN denotes in
T19693 31510-31514 NN denotes size
T19694 31515-31518 CC denotes and
T19695 31519-31530 RB denotes drastically
T19696 31531-31538 VBN denotes reduced
T19698 31539-31543 NN denotes bone
T19697 31544-31550 NN denotes length
T19699 31551-31552 -LRB- denotes [
T19700 31552-31554 CD denotes 53
T19701 31554-31555 -RRB- denotes ]
T19702 31555-31556 . denotes .
T19703 31556-31718 sentence denotes All of these genes are excellent functional and positional hg modifier candidate genes and this information can be incorporated into future fine mapping studies.
T19704 31557-31560 DT denotes All
T19706 31561-31563 IN denotes of
T19707 31564-31569 DT denotes these
T19708 31570-31575 NNS denotes genes
T19705 31576-31579 VBP denotes are
T19709 31580-31589 JJ denotes excellent
T19711 31590-31600 JJ denotes functional
T19712 31601-31604 CC denotes and
T19713 31605-31615 JJ denotes positional
T19714 31616-31618 NN denotes hg
T19715 31619-31627 NN denotes modifier
T19716 31628-31637 NN denotes candidate
T19710 31638-31643 NNS denotes genes
T19717 31644-31647 CC denotes and
T19718 31648-31652 DT denotes this
T19719 31653-31664 NN denotes information
T19721 31665-31668 MD denotes can
T19722 31669-31671 VB denotes be
T19720 31672-31684 VBN denotes incorporated
T19723 31685-31689 IN denotes into
T19724 31690-31696 JJ denotes future
T19726 31697-31701 JJ denotes fine
T19727 31702-31709 NN denotes mapping
T19725 31710-31717 NNS denotes studies
T19728 31717-31718 . denotes .
T19896 31731-31734 DT denotes The
T19898 31735-31740 NN denotes speed
T19899 31741-31749 JJ denotes congenic
T19897 31750-31757 NNS denotes strains
T19901 31758-31767 VBN denotes developed
T19902 31768-31774 RB denotes herein
T19900 31775-31782 VBP denotes confirm
T19903 31783-31793 RB denotes previously
T19904 31794-31804 VBN denotes identified
T19906 31805-31811 NN denotes genome
T19908 31811-31812 HYPH denotes -
T19907 31812-31816 JJ denotes wide
T19905 31817-31820 NN denotes QTL
T19909 31821-31830 VBG denotes affecting
T19910 31831-31837 NN denotes growth
T19911 31837-31839 , denotes ,
T19912 31839-31846 NN denotes obesity
T19913 31847-31850 CC denotes and
T19914 31851-31858 NN denotes carcass
T19915 31859-31870 NN denotes composition
T19916 31870-31871 . denotes .
T19917 31871-32030 sentence denotes Our novel congenic development approach on MMU2 provided confirmation of QTL-hg interactions, which will significantly aid in future fine mapping experiments.
T19918 31872-31875 PRP$ denotes Our
T19920 31876-31881 JJ denotes novel
T19921 31882-31890 JJ denotes congenic
T19922 31891-31902 NN denotes development
T19919 31903-31911 NN denotes approach
T19924 31912-31914 IN denotes on
T19925 31915-31919 NN denotes MMU2
T19923 31920-31928 VBD denotes provided
T19926 31929-31941 NN denotes confirmation
T19927 31942-31944 IN denotes of
T19928 31945-31948 NN denotes QTL
T19930 31948-31949 HYPH denotes -
T19929 31949-31951 NN denotes hg
T19931 31952-31964 NNS denotes interactions
T19932 31964-31966 , denotes ,
T19933 31966-31971 WDT denotes which
T19935 31972-31976 MD denotes will
T19936 31977-31990 RB denotes significantly
T19934 31991-31994 VB denotes aid
T19937 31995-31997 IN denotes in
T19938 31998-32004 JJ denotes future
T19940 32005-32009 JJ denotes fine
T19941 32010-32017 NN denotes mapping
T19939 32018-32029 NNS denotes experiments
T19942 32029-32030 . denotes .
T19943 32030-32239 sentence denotes The identification of the molecular mediators of QTL-hg epistasis as well as the QTG for the remaining congenics will provide essential information on the molecular genetic architecture of growth and obesity.
T19944 32031-32034 DT denotes The
T19945 32035-32049 NN denotes identification
T19947 32050-32052 IN denotes of
T19948 32053-32056 DT denotes the
T19950 32057-32066 JJ denotes molecular
T19949 32067-32076 NNS denotes mediators
T19951 32077-32079 IN denotes of
T19952 32080-32083 NN denotes QTL
T19954 32083-32084 HYPH denotes -
T19953 32084-32086 NN denotes hg
T19955 32087-32096 NN denotes epistasis
T19956 32097-32099 RB denotes as
T19958 32100-32104 RB denotes well
T19957 32105-32107 IN denotes as
T19959 32108-32111 DT denotes the
T19960 32112-32115 NN denotes QTG
T19961 32116-32119 IN denotes for
T19962 32120-32123 DT denotes the
T19964 32124-32133 VBG denotes remaining
T19963 32134-32143 NNS denotes congenics
T19965 32144-32148 MD denotes will
T19946 32149-32156 VB denotes provide
T19966 32157-32166 JJ denotes essential
T19967 32167-32178 NN denotes information
T19968 32179-32181 IN denotes on
T19969 32182-32185 DT denotes the
T19971 32186-32195 JJ denotes molecular
T19972 32196-32203 JJ denotes genetic
T19970 32204-32216 NN denotes architecture
T19973 32217-32219 IN denotes of
T19974 32220-32226 NN denotes growth
T19975 32227-32230 CC denotes and
T19976 32231-32238 NN denotes obesity
T19977 32238-32239 . denotes .
T20228 32250-32255 NN denotes Mouse
T20229 32256-32263 NNS denotes strains
T20230 32264-32267 CC denotes and
T20231 32268-32277 JJ denotes husbandry
T20232 32277-32351 sentence denotes CAST/EiJ (stock #000928) mice were purchased from the Jackson Laboratory.
T20233 32278-32282 NN denotes CAST
T20235 32282-32283 HYPH denotes /
T20234 32283-32286 NN denotes EiJ
T20237 32287-32288 -LRB- denotes (
T20239 32288-32293 NN denotes stock
T20238 32294-32295 NN denotes #
T20240 32295-32301 CD denotes 000928
T20241 32301-32302 -RRB- denotes )
T20236 32303-32307 NNS denotes mice
T20243 32308-32312 VBD denotes were
T20242 32313-32322 VBN denotes purchased
T20244 32323-32327 IN denotes from
T20245 32328-32331 DT denotes the
T20247 32332-32339 NNP denotes Jackson
T20246 32340-32350 NNP denotes Laboratory
T20248 32350-32351 . denotes .
T20249 32351-32519 sentence denotes The hg mutation was originally identified in a selected outcross line [22] and has been introgressed onto a B6 background via nine backcrosses to create the HG strain.
T20250 32352-32355 DT denotes The
T20252 32356-32358 NN denotes hg
T20251 32359-32367 NN denotes mutation
T20254 32368-32371 VBD denotes was
T20255 32372-32382 RB denotes originally
T20253 32383-32393 VBN denotes identified
T20256 32394-32396 IN denotes in
T20257 32397-32398 DT denotes a
T20259 32399-32407 VBN denotes selected
T20260 32408-32416 NN denotes outcross
T20258 32417-32421 NN denotes line
T20261 32422-32423 -LRB- denotes [
T20262 32423-32425 CD denotes 22
T20263 32425-32426 -RRB- denotes ]
T20264 32427-32430 CC denotes and
T20265 32431-32434 VBZ denotes has
T20267 32435-32439 VBN denotes been
T20266 32440-32452 VBN denotes introgressed
T20268 32453-32457 IN denotes onto
T20269 32458-32459 DT denotes a
T20271 32460-32462 NN denotes B6
T20270 32463-32473 NN denotes background
T20272 32474-32477 IN denotes via
T20273 32478-32482 CD denotes nine
T20274 32483-32494 NNS denotes backcrosses
T20275 32495-32497 TO denotes to
T20276 32498-32504 VB denotes create
T20277 32505-32508 DT denotes the
T20279 32509-32511 NN denotes HG
T20278 32512-32518 NN denotes strain
T20280 32518-32519 . denotes .
T20281 32519-32605 sentence denotes HG mice used in this experiment were from the 17th or later generation of inbreeding.
T20282 32520-32522 NN denotes HG
T20283 32523-32527 NNS denotes mice
T20285 32528-32532 VBN denotes used
T20286 32533-32535 IN denotes in
T20287 32536-32540 DT denotes this
T20288 32541-32551 NN denotes experiment
T20284 32552-32556 VBD denotes were
T20289 32557-32561 IN denotes from
T20290 32562-32565 DT denotes the
T20292 32566-32570 JJ denotes 17th
T20293 32571-32573 CC denotes or
T20294 32574-32579 JJ denotes later
T20291 32580-32590 NN denotes generation
T20295 32591-32593 IN denotes of
T20296 32594-32604 NN denotes inbreeding
T20297 32604-32605 . denotes .
T20298 32605-32899 sentence denotes Mice were housed in polycarbonate cages under controlled conditions of temperature (21°C ± 2°C), humidity (40–70%) and lighting (14 h light, 10 h dark, lights on at 7 AM), and managed according to the guidelines of the American Association for Accreditation of Laboratory Animal Care (AAALAC).
T20299 32606-32610 NNS denotes Mice
T20301 32611-32615 VBD denotes were
T20300 32616-32622 VBN denotes housed
T20302 32623-32625 IN denotes in
T20303 32626-32639 NN denotes polycarbonate
T20304 32640-32645 NNS denotes cages
T20305 32646-32651 IN denotes under
T20306 32652-32662 VBN denotes controlled
T20307 32663-32673 NNS denotes conditions
T20308 32674-32676 IN denotes of
T20309 32677-32688 NN denotes temperature
T20310 32689-32690 -LRB- denotes (
T20312 32690-32692 CD denotes 21
T20311 32692-32694 NN denotes °C
T20313 32695-32696 SYM denotes ±
T20314 32697-32698 CD denotes 2
T20315 32698-32700 NN denotes °C
T20316 32700-32701 -RRB- denotes )
T20317 32701-32703 , denotes ,
T20318 32703-32711 NN denotes humidity
T20319 32712-32713 -LRB- denotes (
T20321 32713-32715 CD denotes 40
T20323 32715-32716 SYM denotes –
T20322 32716-32718 CD denotes 70
T20320 32718-32719 NN denotes %
T20324 32719-32720 -RRB- denotes )
T20325 32721-32724 CC denotes and
T20326 32725-32733 NN denotes lighting
T20327 32734-32735 -LRB- denotes (
T20329 32735-32737 CD denotes 14
T20330 32738-32739 NN denotes h
T20331 32740-32745 NN denotes light
T20332 32745-32747 , denotes ,
T20333 32747-32749 CD denotes 10
T20334 32750-32751 NN denotes h
T20328 32752-32756 NN denotes dark
T20335 32756-32758 , denotes ,
T20336 32758-32764 NNS denotes lights
T20337 32765-32767 RB denotes on
T20338 32768-32770 IN denotes at
T20339 32771-32772 CD denotes 7
T20340 32773-32775 NN denotes AM
T20341 32775-32776 -RRB- denotes )
T20342 32776-32778 , denotes ,
T20343 32778-32781 CC denotes and
T20344 32782-32789 VBD denotes managed
T20345 32790-32799 VBG denotes according
T20346 32800-32802 IN denotes to
T20347 32803-32806 DT denotes the
T20348 32807-32817 NNS denotes guidelines
T20349 32818-32820 IN denotes of
T20350 32821-32824 DT denotes the
T20352 32825-32833 NNP denotes American
T20351 32834-32845 NNP denotes Association
T20353 32846-32849 IN denotes for
T20354 32850-32863 NNP denotes Accreditation
T20355 32864-32866 IN denotes of
T20356 32867-32877 NNP denotes Laboratory
T20357 32878-32884 NNP denotes Animal
T20358 32885-32889 NNP denotes Care
T20359 32890-32891 -LRB- denotes (
T20360 32891-32897 NNP denotes AAALAC
T20361 32897-32898 -RRB- denotes )
T20362 32898-32899 . denotes .
T20779 32901-32911 NN denotes Genotyping
T20780 32911-33115 sentence denotes DNA for genotyping was isolated from 1.0–2.0 mm tail clips by digesting with Proteinase K (Fisher) at 55°C in a buffer composed of 0.45% NP40 (Sigma), 0.45% Tween 20 (Fisher) and 1X PCR buffer (Promega).
T20781 32912-32915 NN denotes DNA
T20783 32916-32919 IN denotes for
T20784 32920-32930 NN denotes genotyping
T20785 32931-32934 VBD denotes was
T20782 32935-32943 VBN denotes isolated
T20786 32944-32948 IN denotes from
T20787 32949-32952 CD denotes 1.0
T20789 32952-32953 SYM denotes –
T20788 32953-32956 CD denotes 2.0
T20790 32957-32959 NN denotes mm
T20792 32960-32964 NN denotes tail
T20791 32965-32970 NNS denotes clips
T20793 32971-32973 IN denotes by
T20794 32974-32983 VBG denotes digesting
T20795 32984-32988 IN denotes with
T20796 32989-32999 NN denotes Proteinase
T20797 33000-33001 NN denotes K
T20798 33002-33003 -LRB- denotes (
T20799 33003-33009 NNP denotes Fisher
T20800 33009-33010 -RRB- denotes )
T20801 33011-33013 IN denotes at
T20802 33014-33016 CD denotes 55
T20803 33016-33018 NN denotes °C
T20804 33019-33021 IN denotes in
T20805 33022-33023 DT denotes a
T20806 33024-33030 NN denotes buffer
T20807 33031-33039 VBN denotes composed
T20808 33040-33042 IN denotes of
T20809 33043-33047 CD denotes 0.45
T20810 33047-33048 NN denotes %
T20811 33049-33053 NN denotes NP40
T20812 33054-33055 -LRB- denotes (
T20813 33055-33060 NNP denotes Sigma
T20814 33060-33061 -RRB- denotes )
T20815 33061-33063 , denotes ,
T20816 33063-33067 CD denotes 0.45
T20817 33067-33068 NN denotes %
T20818 33069-33074 NN denotes Tween
T20819 33075-33077 CD denotes 20
T20820 33078-33079 -LRB- denotes (
T20821 33079-33085 NNP denotes Fisher
T20822 33085-33086 -RRB- denotes )
T20823 33087-33090 CC denotes and
T20824 33091-33093 NN denotes 1X
T20826 33094-33097 NN denotes PCR
T20825 33098-33104 NN denotes buffer
T20827 33105-33106 -LRB- denotes (
T20828 33106-33113 NNP denotes Promega
T20829 33113-33114 -RRB- denotes )
T20830 33114-33115 . denotes .
T20831 33115-33233 sentence denotes The product of this digestion was diluted (1:10) in sterile H2O and used for genotyping without further purification.
T20832 33116-33119 DT denotes The
T20833 33120-33127 NN denotes product
T20835 33128-33130 IN denotes of
T20836 33131-33135 DT denotes this
T20837 33136-33145 NN denotes digestion
T20838 33146-33149 VBD denotes was
T20834 33150-33157 VBN denotes diluted
T20839 33158-33159 -LRB- denotes (
T20840 33159-33160 CD denotes 1
T20841 33160-33161 SYM denotes :
T20842 33161-33163 CD denotes 10
T20843 33163-33164 -RRB- denotes )
T20844 33165-33167 IN denotes in
T20845 33168-33175 JJ denotes sterile
T20846 33176-33179 NN denotes H2O
T20847 33180-33183 CC denotes and
T20848 33184-33188 VBN denotes used
T20849 33189-33192 IN denotes for
T20850 33193-33203 NN denotes genotyping
T20851 33204-33211 IN denotes without
T20852 33212-33219 JJ denotes further
T20853 33220-33232 NN denotes purification
T20854 33232-33233 . denotes .
T20855 33233-33327 sentence denotes Microsatellite genotyping was performed using standard PCR and gel electrophoresis protocols.
T20856 33234-33248 NN denotes Microsatellite
T20857 33249-33259 NN denotes genotyping
T20859 33260-33263 VBD denotes was
T20858 33264-33273 VBN denotes performed
T20860 33274-33279 VBG denotes using
T20861 33280-33288 JJ denotes standard
T20863 33289-33292 NN denotes PCR
T20864 33293-33296 CC denotes and
T20865 33297-33300 NN denotes gel
T20866 33301-33316 NN denotes electrophoresis
T20862 33317-33326 NNS denotes protocols
T20867 33326-33327 . denotes .
T20868 33327-33402 sentence denotes Reaction conditions for each marker are listed in Additional File 1 and 2.
T20869 33328-33336 NN denotes Reaction
T20870 33337-33347 NNS denotes conditions
T20872 33348-33351 IN denotes for
T20873 33352-33356 DT denotes each
T20874 33357-33363 NN denotes marker
T20875 33364-33367 VBP denotes are
T20871 33368-33374 VBN denotes listed
T20876 33375-33377 IN denotes in
T20877 33378-33388 JJ denotes Additional
T20879 33389-33393 NN denotes File
T20878 33394-33395 CD denotes 1
T20880 33396-33399 CC denotes and
T20881 33400-33401 CD denotes 2
T20882 33401-33402 . denotes .
T20883 33402-33480 sentence denotes MMU2 congenic mice were genotyped for hg using a two primer genotyping assay.
T20884 33403-33407 NN denotes MMU2
T20885 33408-33416 JJ denotes congenic
T20886 33417-33421 NNS denotes mice
T20888 33422-33426 VBD denotes were
T20887 33427-33436 VBN denotes genotyped
T20889 33437-33440 IN denotes for
T20890 33441-33443 NN denotes hg
T20891 33444-33449 VBG denotes using
T20892 33450-33451 DT denotes a
T20894 33452-33455 CD denotes two
T20895 33456-33462 NN denotes primer
T20896 33463-33473 NN denotes genotyping
T20893 33474-33479 NN denotes assay
T20897 33479-33480 . denotes .
T20898 33480-33629 sentence denotes One primer set (HG-F, ctcctgtctgggctgtgag and HG-R, caaaggcagaagtggggtaa) spanned the hg deletion producing a 447 bp product in hg/hg and +/hg mice.
T20899 33481-33484 CD denotes One
T20901 33485-33491 NN denotes primer
T20900 33492-33495 NN denotes set
T20903 33496-33497 -LRB- denotes (
T20904 33497-33499 NN denotes HG
T20906 33499-33500 HYPH denotes -
T20905 33500-33501 NN denotes F
T20907 33501-33503 , denotes ,
T20908 33503-33522 NN denotes ctcctgtctgggctgtgag
T20909 33523-33526 CC denotes and
T20910 33527-33529 NN denotes HG
T20912 33529-33530 HYPH denotes -
T20911 33530-33531 NN denotes R
T20913 33531-33533 , denotes ,
T20914 33533-33553 NN denotes caaaggcagaagtggggtaa
T20915 33553-33554 -RRB- denotes )
T20902 33555-33562 VBD denotes spanned
T20916 33563-33566 DT denotes the
T20918 33567-33569 NN denotes hg
T20917 33570-33578 NN denotes deletion
T20919 33579-33588 VBG denotes producing
T20920 33589-33590 DT denotes a
T20922 33591-33594 CD denotes 447
T20923 33595-33597 NN denotes bp
T20921 33598-33605 NN denotes product
T20924 33606-33608 IN denotes in
T20925 33609-33611 NN denotes hg
T20927 33611-33612 HYPH denotes /
T20926 33612-33614 NN denotes hg
T20929 33615-33618 CC denotes and
T20930 33619-33620 SYM denotes +
T20932 33620-33621 HYPH denotes /
T20931 33621-33623 NN denotes hg
T20928 33624-33628 NNS denotes mice
T20933 33628-33629 . denotes .
T20934 33629-33806 sentence denotes The other set (CRADD3a.F, gtccatcagcattcctgaaa and CRADD3.R, tgtccagcaacagcattgtc) amplified a 232 bp Cradd amplicon (located within the hg deletion) in +/+ and +/hg mice [54].
T20935 33630-33633 DT denotes The
T20937 33634-33639 JJ denotes other
T20936 33640-33643 NN denotes set
T20939 33644-33645 -LRB- denotes (
T20940 33645-33654 NN denotes CRADD3a.F
T20941 33654-33656 , denotes ,
T20942 33656-33676 NN denotes gtccatcagcattcctgaaa
T20943 33677-33680 CC denotes and
T20944 33681-33689 NN denotes CRADD3.R
T20945 33689-33691 , denotes ,
T20946 33691-33711 NN denotes tgtccagcaacagcattgtc
T20947 33711-33712 -RRB- denotes )
T20938 33713-33722 VBD denotes amplified
T20948 33723-33724 DT denotes a
T20950 33725-33728 CD denotes 232
T20951 33729-33731 NN denotes bp
T20952 33732-33737 NN denotes Cradd
T20949 33738-33746 NN denotes amplicon
T20953 33747-33748 -LRB- denotes (
T20954 33748-33755 VBN denotes located
T20955 33756-33762 IN denotes within
T20956 33763-33766 DT denotes the
T20958 33767-33769 NN denotes hg
T20957 33770-33778 NN denotes deletion
T20959 33778-33779 -RRB- denotes )
T20960 33780-33782 IN denotes in
T20961 33783-33784 SYM denotes +
T20963 33784-33785 HYPH denotes /
T20962 33785-33786 SYM denotes +
T20965 33787-33790 CC denotes and
T20966 33791-33792 SYM denotes +
T20968 33792-33793 HYPH denotes /
T20967 33793-33795 NN denotes hg
T20964 33796-33800 NNS denotes mice
T20969 33801-33802 -LRB- denotes [
T20970 33802-33804 CD denotes 54
T20971 33804-33805 -RRB- denotes ]
T20972 33805-33806 . denotes .
T20973 33806-33885 sentence denotes The PCR annealing temperature was 55°C and the MgCl2 concentration was 1.5 mM.
T20974 33807-33810 DT denotes The
T20976 33811-33814 NN denotes PCR
T20977 33815-33824 VBG denotes annealing
T20975 33825-33836 NN denotes temperature
T20978 33837-33840 VBD denotes was
T20979 33841-33843 CD denotes 55
T20980 33843-33845 NN denotes °C
T20981 33846-33849 CC denotes and
T20982 33850-33853 DT denotes the
T20984 33854-33859 NN denotes MgCl2
T20983 33860-33873 NN denotes concentration
T20985 33874-33877 VBD denotes was
T20986 33878-33881 CD denotes 1.5
T20987 33882-33884 NN denotes mM
T20988 33884-33885 . denotes .
T21607 33887-33898 NN denotes Development
T21608 33899-33901 IN denotes of
T21609 33902-33909 NN denotes B6.CAST
T21611 33910-33913 CC denotes and
T21612 33914-33921 NN denotes HG.CAST
T21610 33922-33926 NN denotes MMU2
T21614 33927-33932 NN denotes speed
T21615 33933-33941 JJ denotes congenic
T21613 33942-33949 NNS denotes strains
T21616 33949-34075 sentence denotes All speed congenic strains were developed starting with an initial cross between a CAST male and HG females (Figure 1) [5,6].
T21617 33950-33953 DT denotes All
T21619 33954-33959 NN denotes speed
T21620 33960-33968 JJ denotes congenic
T21618 33969-33976 NNS denotes strains
T21622 33977-33981 VBD denotes were
T21621 33982-33991 VBN denotes developed
T21623 33992-34000 VBG denotes starting
T21624 34001-34005 IN denotes with
T21625 34006-34008 DT denotes an
T21627 34009-34016 JJ denotes initial
T21626 34017-34022 NN denotes cross
T21628 34023-34030 IN denotes between
T21629 34031-34032 DT denotes a
T21631 34033-34037 NN denotes CAST
T21630 34038-34042 NN denotes male
T21632 34043-34046 CC denotes and
T21633 34047-34049 NN denotes HG
T21634 34050-34057 NNS denotes females
T21635 34058-34059 -LRB- denotes (
T21636 34059-34065 NN denotes Figure
T21637 34066-34067 CD denotes 1
T21638 34067-34068 -RRB- denotes )
T21639 34069-34070 -LRB- denotes [
T21641 34070-34071 CD denotes 5
T21642 34071-34072 , denotes ,
T21640 34072-34073 CD denotes 6
T21643 34073-34074 -RRB- denotes ]
T21644 34074-34075 . denotes .
T21645 34075-34125 sentence denotes Male F1 mice were then backcrossed to HG females.
T21646 34076-34080 JJ denotes Male
T21648 34081-34083 NN denotes F1
T21647 34084-34088 NNS denotes mice
T21650 34089-34093 VBD denotes were
T21651 34094-34098 RB denotes then
T21649 34099-34110 VBN denotes backcrossed
T21652 34111-34113 IN denotes to
T21653 34114-34116 NN denotes HG
T21654 34117-34124 NNS denotes females
T21655 34124-34125 . denotes .
T21656 34125-34278 sentence denotes All agouti (the dominant nonagouti (a) locus is located at 154.8 Mbp on MMU2) N2 males were genotyped for 79 microsatellite markers (Additional File 1).
T21657 34126-34129 DT denotes All
T21659 34130-34136 NN denotes agouti
T21660 34137-34138 -LRB- denotes (
T21662 34138-34141 DT denotes the
T21664 34142-34150 JJ denotes dominant
T21665 34151-34160 JJ denotes nonagouti
T21667 34161-34162 -LRB- denotes (
T21666 34162-34163 NN denotes a
T21668 34163-34164 -RRB- denotes )
T21663 34165-34170 NN denotes locus
T21669 34171-34173 VBZ denotes is
T21661 34174-34181 VBN denotes located
T21670 34182-34184 IN denotes at
T21671 34185-34190 CD denotes 154.8
T21672 34191-34194 NN denotes Mbp
T21673 34195-34197 IN denotes on
T21674 34198-34202 NN denotes MMU2
T21675 34202-34203 -RRB- denotes )
T21676 34204-34206 NN denotes N2
T21658 34207-34212 NNS denotes males
T21678 34213-34217 VBD denotes were
T21677 34218-34227 VBN denotes genotyped
T21679 34228-34231 IN denotes for
T21680 34232-34234 CD denotes 79
T21682 34235-34249 NN denotes microsatellite
T21681 34250-34257 NNS denotes markers
T21683 34258-34259 -LRB- denotes (
T21685 34259-34269 JJ denotes Additional
T21684 34270-34274 NN denotes File
T21686 34275-34276 CD denotes 1
T21687 34276-34277 -RRB- denotes )
T21688 34277-34278 . denotes .
T21689 34278-34426 sentence denotes These markers were evenly spaced across the genome, except in regions previously identified as harboring QTL [1], which were more densely screened.
T21690 34279-34284 DT denotes These
T21691 34285-34292 NNS denotes markers
T21693 34293-34297 VBD denotes were
T21694 34298-34304 RB denotes evenly
T21692 34305-34311 VBN denotes spaced
T21695 34312-34318 IN denotes across
T21696 34319-34322 DT denotes the
T21697 34323-34329 NN denotes genome
T21698 34329-34331 , denotes ,
T21699 34331-34337 RB denotes except
T21700 34338-34340 IN denotes in
T21701 34341-34348 NNS denotes regions
T21702 34349-34359 RB denotes previously
T21703 34360-34370 VBN denotes identified
T21704 34371-34373 IN denotes as
T21705 34374-34383 VBG denotes harboring
T21706 34384-34387 NN denotes QTL
T21707 34388-34389 -LRB- denotes [
T21708 34389-34390 CD denotes 1
T21709 34390-34391 -RRB- denotes ]
T21710 34391-34393 , denotes ,
T21711 34393-34398 WDT denotes which
T21713 34399-34403 VBD denotes were
T21714 34404-34408 RBR denotes more
T21715 34409-34416 RB denotes densely
T21712 34417-34425 VBN denotes screened
T21716 34425-34426 . denotes .
T21717 34426-34592 sentence denotes The "best" N2 agouti male with the lowest level of genome-wide unwanted heterozygosity while maintaining CAST alleles for all MMU2 markers was selected for breeding.
T21718 34427-34430 DT denotes The
T21720 34431-34432 `` denotes "
T21721 34432-34436 JJS denotes best
T21722 34436-34437 '' denotes "
T21723 34438-34440 NN denotes N2
T21724 34441-34447 NN denotes agouti
T21719 34448-34452 NN denotes male
T21726 34453-34457 IN denotes with
T21727 34458-34461 DT denotes the
T21729 34462-34468 JJS denotes lowest
T21728 34469-34474 NN denotes level
T21730 34475-34477 IN denotes of
T21731 34478-34484 NN denotes genome
T21733 34484-34485 HYPH denotes -
T21732 34485-34489 JJ denotes wide
T21735 34490-34498 JJ denotes unwanted
T21734 34499-34513 NN denotes heterozygosity
T21736 34514-34519 IN denotes while
T21737 34520-34531 VBG denotes maintaining
T21738 34532-34536 NN denotes CAST
T21739 34537-34544 NNS denotes alleles
T21740 34545-34548 IN denotes for
T21741 34549-34552 DT denotes all
T21743 34553-34557 NN denotes MMU2
T21742 34558-34565 NNS denotes markers
T21744 34566-34569 VBD denotes was
T21725 34570-34578 VBN denotes selected
T21745 34579-34582 IN denotes for
T21746 34583-34591 NN denotes breeding
T21747 34591-34592 . denotes .
T21748 34592-34726 sentence denotes This selection scheme was used at each generation until a N4 male was identified as homozygous HG for all markers typed outside MMU2.
T21749 34593-34597 DT denotes This
T21751 34598-34607 NN denotes selection
T21750 34608-34614 NN denotes scheme
T21753 34615-34618 VBD denotes was
T21752 34619-34623 VBN denotes used
T21754 34624-34626 IN denotes at
T21755 34627-34631 DT denotes each
T21756 34632-34642 NN denotes generation
T21757 34643-34648 IN denotes until
T21759 34649-34650 DT denotes a
T21761 34651-34653 NN denotes N4
T21760 34654-34658 NN denotes male
T21762 34659-34662 VBD denotes was
T21758 34663-34673 VBN denotes identified
T21763 34674-34676 IN denotes as
T21764 34677-34687 JJ denotes homozygous
T21765 34688-34690 NN denotes HG
T21766 34691-34694 IN denotes for
T21767 34695-34698 DT denotes all
T21768 34699-34706 NNS denotes markers
T21769 34707-34712 VBN denotes typed
T21770 34713-34720 IN denotes outside
T21771 34721-34725 NN denotes MMU2
T21772 34725-34726 . denotes .
T21773 34726-34870 sentence denotes After an additional backcross to HG females, recombinant males were identified providing the foundation for the four overlapping donor regions.
T21774 34727-34732 IN denotes After
T21776 34733-34735 DT denotes an
T21778 34736-34746 JJ denotes additional
T21777 34747-34756 NN denotes backcross
T21779 34757-34759 IN denotes to
T21780 34760-34762 NN denotes HG
T21781 34763-34770 NNS denotes females
T21782 34770-34772 , denotes ,
T21783 34772-34783 JJ denotes recombinant
T21784 34784-34789 NNS denotes males
T21785 34790-34794 VBD denotes were
T21775 34795-34805 VBN denotes identified
T21786 34806-34815 VBG denotes providing
T21787 34816-34819 DT denotes the
T21788 34820-34830 NN denotes foundation
T21789 34831-34834 IN denotes for
T21790 34835-34838 DT denotes the
T21792 34839-34843 CD denotes four
T21793 34844-34855 VBG denotes overlapping
T21794 34856-34861 NN denotes donor
T21791 34862-34869 NNS denotes regions
T21795 34869-34870 . denotes .
T21796 34870-35025 sentence denotes Selected recombinant males were then backcrossed to both B6 and HG females to create strains, which were B6 (+/+) or HG (hg/hg) and heterozygous congenic.
T21797 34871-34879 VBN denotes Selected
T21799 34880-34891 JJ denotes recombinant
T21798 34892-34897 NNS denotes males
T21801 34898-34902 VBD denotes were
T21802 34903-34907 RB denotes then
T21800 34908-34919 VBN denotes backcrossed
T21803 34920-34922 IN denotes to
T21804 34923-34927 CC denotes both
T21805 34928-34930 NN denotes B6
T21807 34931-34934 CC denotes and
T21808 34935-34937 NN denotes HG
T21806 34938-34945 NNS denotes females
T21809 34946-34948 TO denotes to
T21810 34949-34955 VB denotes create
T21811 34956-34963 NNS denotes strains
T21812 34963-34965 , denotes ,
T21813 34965-34970 WDT denotes which
T21814 34971-34975 VBD denotes were
T21815 34976-34978 NN denotes B6
T21817 34979-34980 -LRB- denotes (
T21819 34980-34981 SYM denotes +
T21820 34981-34982 HYPH denotes /
T21818 34982-34983 SYM denotes +
T21821 34983-34984 -RRB- denotes )
T21822 34985-34987 CC denotes or
T21823 34988-34990 NN denotes HG
T21824 34991-34992 -LRB- denotes (
T21826 34992-34994 NN denotes hg
T21827 34994-34995 HYPH denotes /
T21825 34995-34997 NN denotes hg
T21828 34997-34998 -RRB- denotes )
T21829 34999-35002 CC denotes and
T21830 35003-35015 JJ denotes heterozygous
T21816 35016-35024 JJ denotes congenic
T21831 35024-35025 . denotes .
T21832 35025-35100 sentence denotes These mice were intermated to produce homozygous founders for each strain.
T21833 35026-35031 DT denotes These
T21834 35032-35036 NNS denotes mice
T21836 35037-35041 VBD denotes were
T21835 35042-35052 VBN denotes intermated
T21837 35053-35055 TO denotes to
T21838 35056-35063 VB denotes produce
T21839 35064-35074 JJ denotes homozygous
T21840 35075-35083 NNS denotes founders
T21841 35084-35087 IN denotes for
T21842 35088-35092 DT denotes each
T21843 35093-35099 NN denotes strain
T21844 35099-35100 . denotes .
T21845 35100-35314 sentence denotes This novel breeding scheme created four identical founder congenics on two backgrounds B6 (+/+) and HG (hg/hg), which formed the basis for our examination of interactions caused by the presence of the hg deletion.
T21846 35101-35105 DT denotes This
T21848 35106-35111 JJ denotes novel
T21849 35112-35120 VBG denotes breeding
T21847 35121-35127 NN denotes scheme
T21850 35128-35135 VBD denotes created
T21851 35136-35140 CD denotes four
T21853 35141-35150 JJ denotes identical
T21854 35151-35158 NN denotes founder
T21852 35159-35168 NNS denotes congenics
T21855 35169-35171 IN denotes on
T21856 35172-35175 CD denotes two
T21857 35176-35187 NNS denotes backgrounds
T21858 35188-35190 NN denotes B6
T21859 35191-35192 -LRB- denotes (
T21861 35192-35193 SYM denotes +
T21862 35193-35194 HYPH denotes /
T21860 35194-35195 SYM denotes +
T21863 35195-35196 -RRB- denotes )
T21864 35197-35200 CC denotes and
T21865 35201-35203 NN denotes HG
T21866 35204-35205 -LRB- denotes (
T21868 35205-35207 NN denotes hg
T21869 35207-35208 HYPH denotes /
T21867 35208-35210 NN denotes hg
T21870 35210-35211 -RRB- denotes )
T21871 35211-35213 , denotes ,
T21872 35213-35218 WDT denotes which
T21873 35219-35225 VBD denotes formed
T21874 35226-35229 DT denotes the
T21875 35230-35235 NN denotes basis
T21876 35236-35239 IN denotes for
T21877 35240-35243 PRP$ denotes our
T21878 35244-35255 NN denotes examination
T21879 35256-35258 IN denotes of
T21880 35259-35271 NNS denotes interactions
T21881 35272-35278 VBN denotes caused
T21882 35279-35281 IN denotes by
T21883 35282-35285 DT denotes the
T21884 35286-35294 NN denotes presence
T21885 35295-35297 IN denotes of
T21886 35298-35301 DT denotes the
T21888 35302-35304 NN denotes hg
T21887 35305-35313 NN denotes deletion
T21889 35313-35314 . denotes .
T21890 35314-35389 sentence denotes MMU2 speed congenic strains were maintained through brother-sister mating.
T21891 35315-35319 NN denotes MMU2
T21893 35320-35325 NN denotes speed
T21894 35326-35334 JJ denotes congenic
T21892 35335-35342 NNS denotes strains
T21896 35343-35347 VBD denotes were
T21895 35348-35358 VBN denotes maintained
T21897 35359-35366 IN denotes through
T21898 35367-35374 NN denotes brother
T21900 35374-35375 HYPH denotes -
T21899 35375-35381 NN denotes sister
T21901 35382-35388 NN denotes mating
T21902 35388-35389 . denotes .
T21903 35389-35554 sentence denotes Once each congenic was stabilized, 20 additional microsatellite markers were used to refine the position of each congenic recombinant end point (Additional File 2).
T21904 35390-35394 RB denotes Once
T21906 35395-35399 DT denotes each
T21907 35400-35408 JJ denotes congenic
T21908 35409-35412 VBD denotes was
T21905 35413-35423 VBN denotes stabilized
T21910 35423-35425 , denotes ,
T21911 35425-35427 CD denotes 20
T21913 35428-35438 JJ denotes additional
T21914 35439-35453 NN denotes microsatellite
T21912 35454-35461 NNS denotes markers
T21915 35462-35466 VBD denotes were
T21909 35467-35471 VBN denotes used
T21916 35472-35474 TO denotes to
T21917 35475-35481 VB denotes refine
T21918 35482-35485 DT denotes the
T21919 35486-35494 NN denotes position
T21920 35495-35497 IN denotes of
T21921 35498-35502 DT denotes each
T21923 35503-35511 JJ denotes congenic
T21924 35512-35523 JJ denotes recombinant
T21925 35524-35527 NN denotes end
T21922 35528-35533 NN denotes point
T21926 35534-35535 -LRB- denotes (
T21928 35535-35545 JJ denotes Additional
T21927 35546-35550 NN denotes File
T21929 35551-35552 CD denotes 2
T21930 35552-35553 -RRB- denotes )
T21931 35553-35554 . denotes .
T22598 35556-35567 NN denotes Development
T22599 35568-35570 IN denotes of
T22600 35571-35578 NN denotes HG.CAST
T22602 35579-35584 NN denotes speed
T22603 35585-35593 JJ denotes congenic
T22601 35594-35601 NNS denotes strains
T22604 35602-35605 IN denotes for
T22605 35606-35609 NN denotes MMU
T22606 35609-35610 CD denotes 1
T22607 35610-35612 , denotes ,
T22608 35612-35613 CD denotes 5
T22609 35613-35615 , denotes ,
T22610 35615-35616 CD denotes 8
T22611 35616-35618 , denotes ,
T22612 35618-35619 CD denotes 9
T22613 35619-35621 , denotes ,
T22614 35621-35623 CD denotes 11
T22615 35624-35627 CC denotes and
T22616 35628-35630 CD denotes 17
T22617 35630-35933 sentence denotes All black N2 males from the first two crosses described above were genotyped for 12 markers (D1Mit432, -480, D5Mit353, -311, D9Mit60, -262, D11Mit5, -67, D8Mit234, -211 and D17Mit28 and -142), two spanning each of the six QTL harboring regions (MMU1, 5, 8, 9, 11 and 17; Table 1 and Additional File 1).
T22618 35631-35634 DT denotes All
T22620 35635-35640 JJ denotes black
T22621 35641-35643 NN denotes N2
T22619 35644-35649 NNS denotes males
T22623 35650-35654 IN denotes from
T22624 35655-35658 DT denotes the
T22626 35659-35664 JJ denotes first
T22627 35665-35668 CD denotes two
T22625 35669-35676 NNS denotes crosses
T22628 35677-35686 VBN denotes described
T22629 35687-35692 RB denotes above
T22630 35693-35697 VBD denotes were
T22622 35698-35707 VBN denotes genotyped
T22631 35708-35711 IN denotes for
T22632 35712-35714 CD denotes 12
T22633 35715-35722 NNS denotes markers
T22634 35723-35724 -LRB- denotes (
T22635 35724-35732 NN denotes D1Mit432
T22636 35732-35734 , denotes ,
T22637 35734-35735 SYM denotes -
T22638 35735-35738 CD denotes 480
T22639 35738-35740 , denotes ,
T22640 35740-35748 NN denotes D5Mit353
T22641 35748-35750 , denotes ,
T22642 35750-35751 SYM denotes -
T22643 35751-35754 CD denotes 311
T22644 35754-35756 , denotes ,
T22645 35756-35763 NN denotes D9Mit60
T22646 35763-35765 , denotes ,
T22647 35765-35766 SYM denotes -
T22648 35766-35769 CD denotes 262
T22649 35769-35771 , denotes ,
T22650 35771-35778 NN denotes D11Mit5
T22651 35778-35780 , denotes ,
T22652 35780-35781 SYM denotes -
T22653 35781-35783 CD denotes 67
T22654 35783-35785 , denotes ,
T22655 35785-35793 NN denotes D8Mit234
T22656 35793-35795 , denotes ,
T22657 35795-35796 SYM denotes -
T22658 35796-35799 CD denotes 211
T22659 35800-35803 CC denotes and
T22660 35804-35812 NN denotes D17Mit28
T22661 35813-35816 CC denotes and
T22662 35817-35818 SYM denotes -
T22663 35818-35821 CD denotes 142
T22664 35821-35822 -RRB- denotes )
T22665 35822-35824 , denotes ,
T22666 35824-35827 CD denotes two
T22667 35828-35836 VBG denotes spanning
T22668 35837-35841 DT denotes each
T22669 35842-35844 IN denotes of
T22670 35845-35848 DT denotes the
T22672 35849-35852 CD denotes six
T22673 35853-35856 NNS denotes QTL
T22674 35857-35866 VBG denotes harboring
T22671 35867-35874 NNS denotes regions
T22675 35875-35876 -LRB- denotes (
T22676 35876-35879 NN denotes MMU
T22677 35879-35880 CD denotes 1
T22678 35880-35882 , denotes ,
T22679 35882-35883 CD denotes 5
T22680 35883-35885 , denotes ,
T22681 35885-35886 CD denotes 8
T22682 35886-35888 , denotes ,
T22683 35888-35889 CD denotes 9
T22684 35889-35891 , denotes ,
T22685 35891-35893 CD denotes 11
T22686 35894-35897 CC denotes and
T22687 35898-35900 CD denotes 17
T22688 35900-35901 : denotes ;
T22689 35902-35907 NN denotes Table
T22690 35908-35909 CD denotes 1
T22691 35910-35913 CC denotes and
T22692 35914-35924 JJ denotes Additional
T22693 35925-35929 NN denotes File
T22694 35930-35931 CD denotes 1
T22695 35931-35932 -RRB- denotes )
T22696 35932-35933 . denotes .
T22697 35933-36009 sentence denotes Markers were selected to capture, at a minimum, the 2-LOD support interval.
T22698 35934-35941 NNS denotes Markers
T22700 35942-35946 VBD denotes were
T22699 35947-35955 VBN denotes selected
T22701 35956-35958 TO denotes to
T22702 35959-35966 VB denotes capture
T22703 35966-35968 , denotes ,
T22704 35968-35970 IN denotes at
T22705 35971-35972 DT denotes a
T22706 35973-35980 NN denotes minimum
T22707 35980-35982 , denotes ,
T22708 35982-35985 DT denotes the
T22710 35986-35987 CD denotes 2
T22712 35987-35988 HYPH denotes -
T22711 35988-35991 NN denotes LOD
T22713 35992-35999 NN denotes support
T22709 36000-36008 NN denotes interval
T22714 36008-36009 . denotes .
T22715 36009-36176 sentence denotes Two N2 males were selected to propagate the N3 generation; one heterozygous for QTL on MMU1 and 9 and the other heterozygous for QTL on MMU5, 8, 11 and 17 (Figure 1).
T22716 36010-36013 CD denotes Two
T22718 36014-36016 NN denotes N2
T22717 36017-36022 NNS denotes males
T22720 36023-36027 VBD denotes were
T22719 36028-36036 VBN denotes selected
T22721 36037-36039 TO denotes to
T22722 36040-36049 VB denotes propagate
T22723 36050-36053 DT denotes the
T22725 36054-36056 NN denotes N3
T22724 36057-36067 NN denotes generation
T22726 36067-36068 : denotes ;
T22727 36069-36072 CD denotes one
T22728 36073-36085 JJ denotes heterozygous
T22729 36086-36089 IN denotes for
T22730 36090-36093 NN denotes QTL
T22731 36094-36096 IN denotes on
T22732 36097-36100 NN denotes MMU
T22733 36100-36101 CD denotes 1
T22734 36102-36105 CC denotes and
T22735 36106-36107 CD denotes 9
T22736 36108-36111 CC denotes and
T22737 36112-36115 DT denotes the
T22738 36116-36121 JJ denotes other
T22739 36122-36134 NN denotes heterozygous
T22740 36135-36138 IN denotes for
T22741 36139-36142 NN denotes QTL
T22742 36143-36145 IN denotes on
T22743 36146-36149 NN denotes MMU
T22744 36149-36150 CD denotes 5
T22745 36150-36152 , denotes ,
T22746 36152-36153 CD denotes 8
T22747 36153-36155 , denotes ,
T22748 36155-36157 CD denotes 11
T22749 36158-36161 CC denotes and
T22750 36162-36164 CD denotes 17
T22751 36165-36166 -LRB- denotes (
T22752 36166-36172 NN denotes Figure
T22753 36173-36174 CD denotes 1
T22754 36174-36175 -RRB- denotes )
T22755 36175-36176 . denotes .
T22756 36176-36242 sentence denotes Both males were homozygous for HG alleles at all other known QTL.
T22757 36177-36181 DT denotes Both
T22758 36182-36187 NNS denotes males
T22759 36188-36192 VBD denotes were
T22760 36193-36203 JJ denotes homozygous
T22761 36204-36207 IN denotes for
T22762 36208-36210 NN denotes HG
T22763 36211-36218 NNS denotes alleles
T22764 36219-36221 IN denotes at
T22765 36222-36225 DT denotes all
T22767 36226-36231 JJ denotes other
T22768 36232-36237 VBN denotes known
T22766 36238-36241 NN denotes QTL
T22769 36241-36242 . denotes .
T22770 36242-36393 sentence denotes These males were backcrossed to HG females and two of the resulting N3 males inheriting the same sets of QTL as their sire were selected for breeding.
T22771 36243-36248 DT denotes These
T22772 36249-36254 NNS denotes males
T22774 36255-36259 VBD denotes were
T22773 36260-36271 VBN denotes backcrossed
T22775 36272-36274 IN denotes to
T22776 36275-36277 NN denotes HG
T22777 36278-36285 NNS denotes females
T22778 36286-36289 CC denotes and
T22779 36290-36293 CD denotes two
T22781 36294-36296 IN denotes of
T22782 36297-36300 DT denotes the
T22784 36301-36310 VBG denotes resulting
T22785 36311-36313 NN denotes N3
T22783 36314-36319 NNS denotes males
T22786 36320-36330 VBG denotes inheriting
T22787 36331-36334 DT denotes the
T22789 36335-36339 JJ denotes same
T22788 36340-36344 NNS denotes sets
T22790 36345-36347 IN denotes of
T22791 36348-36351 NN denotes QTL
T22792 36352-36354 IN denotes as
T22793 36355-36360 PRP$ denotes their
T22794 36361-36365 NN denotes sire
T22795 36366-36370 VBD denotes were
T22780 36371-36379 VBN denotes selected
T22796 36380-36383 IN denotes for
T22797 36384-36392 NN denotes breeding
T22798 36392-36393 . denotes .
T22799 36393-36586 sentence denotes These males were subsequently backcrossed to HG females and three N4 males were identified heterozygous for the following regions: 1) MMU1 and 9; 2) MMU5 and 11; 3) MMU8, 11 and 17 (Figure 1).
T22800 36394-36399 DT denotes These
T22801 36400-36405 NNS denotes males
T22803 36406-36410 VBD denotes were
T22804 36411-36423 RB denotes subsequently
T22802 36424-36435 VBN denotes backcrossed
T22805 36436-36438 IN denotes to
T22806 36439-36441 NN denotes HG
T22807 36442-36449 NNS denotes females
T22808 36450-36453 CC denotes and
T22809 36454-36459 CD denotes three
T22811 36460-36462 NN denotes N4
T22810 36463-36468 NNS denotes males
T22813 36469-36473 VBD denotes were
T22812 36474-36484 VBN denotes identified
T22814 36485-36497 JJ denotes heterozygous
T22815 36498-36501 IN denotes for
T22816 36502-36505 DT denotes the
T22818 36506-36515 VBG denotes following
T22817 36516-36523 NNS denotes regions
T22819 36523-36525 : denotes :
T22820 36525-36526 LS denotes 1
T22822 36526-36527 -RRB- denotes )
T22823 36528-36531 NN denotes MMU
T22821 36531-36532 CD denotes 1
T22824 36533-36536 CC denotes and
T22825 36537-36538 CD denotes 9
T22826 36538-36539 : denotes ;
T22827 36540-36541 LS denotes 2
T22829 36541-36542 -RRB- denotes )
T22830 36543-36546 NN denotes MMU
T22828 36546-36547 CD denotes 5
T22831 36548-36551 CC denotes and
T22832 36552-36554 CD denotes 11
T22833 36554-36555 : denotes ;
T22834 36556-36557 LS denotes 3
T22836 36557-36558 -RRB- denotes )
T22837 36559-36562 NN denotes MMU
T22835 36562-36563 CD denotes 8
T22838 36563-36565 , denotes ,
T22839 36565-36567 CD denotes 11
T22840 36568-36571 CC denotes and
T22841 36572-36574 CD denotes 17
T22842 36575-36576 -LRB- denotes (
T22843 36576-36582 NN denotes Figure
T22844 36583-36584 CD denotes 1
T22845 36584-36585 -RRB- denotes )
T22846 36585-36586 . denotes .
T22847 36586-36893 sentence denotes Starting at N4 and continuing through N6, the "best" male with the lowest percent of unwanted donor alleles was selected after performing a genome scan using the remaining 67 genome-wide markers (79 total markers minus the 12 markers genotyped in the first two backcrosses spanning the know QTL intervals).
T22848 36587-36595 VBG denotes Starting
T22850 36596-36598 IN denotes at
T22851 36599-36601 NN denotes N4
T22852 36602-36605 CC denotes and
T22853 36606-36616 VBG denotes continuing
T22854 36617-36624 IN denotes through
T22855 36625-36627 NN denotes N6
T22856 36627-36629 , denotes ,
T22857 36629-36632 DT denotes the
T22859 36633-36634 `` denotes "
T22860 36634-36638 JJS denotes best
T22861 36638-36639 '' denotes "
T22858 36640-36644 JJ denotes male
T22862 36645-36649 IN denotes with
T22863 36650-36653 DT denotes the
T22865 36654-36660 JJS denotes lowest
T22864 36661-36668 NN denotes percent
T22866 36669-36671 IN denotes of
T22867 36672-36680 JJ denotes unwanted
T22869 36681-36686 NN denotes donor
T22868 36687-36694 NNS denotes alleles
T22870 36695-36698 VBD denotes was
T22849 36699-36707 VBN denotes selected
T22871 36708-36713 IN denotes after
T22872 36714-36724 VBG denotes performing
T22873 36725-36726 DT denotes a
T22875 36727-36733 NN denotes genome
T22874 36734-36738 NN denotes scan
T22876 36739-36744 VBG denotes using
T22877 36745-36748 DT denotes the
T22879 36749-36758 VBG denotes remaining
T22880 36759-36761 CD denotes 67
T22881 36762-36768 NN denotes genome
T22883 36768-36769 HYPH denotes -
T22882 36769-36773 JJ denotes wide
T22878 36774-36781 NNS denotes markers
T22884 36782-36783 -LRB- denotes (
T22886 36783-36785 CD denotes 79
T22887 36786-36791 JJ denotes total
T22885 36792-36799 NNS denotes markers
T22888 36800-36805 CC denotes minus
T22889 36806-36809 DT denotes the
T22891 36810-36812 CD denotes 12
T22890 36813-36820 NNS denotes markers
T22892 36821-36830 VBN denotes genotyped
T22893 36831-36833 IN denotes in
T22894 36834-36837 DT denotes the
T22896 36838-36843 JJ denotes first
T22897 36844-36847 CD denotes two
T22895 36848-36859 NNS denotes backcrosses
T22898 36860-36868 VBG denotes spanning
T22899 36869-36872 DT denotes the
T22901 36873-36877 JJ denotes know
T22902 36878-36881 NN denotes QTL
T22900 36882-36891 NNS denotes intervals
T22903 36891-36892 -RRB- denotes )
T22904 36892-36893 . denotes .
T22905 36893-37024 sentence denotes At N5 a distinct strain was created for each of the six individual donor regions and heterozygous mice were intermated (Figure 1).
T22906 36894-36896 IN denotes At
T22908 36897-36899 NN denotes N5
T22909 36900-36901 DT denotes a
T22911 36902-36910 JJ denotes distinct
T22910 36911-36917 NN denotes strain
T22912 36918-36921 VBD denotes was
T22907 36922-36929 VBN denotes created
T22913 36930-36933 IN denotes for
T22914 36934-36938 DT denotes each
T22915 36939-36941 IN denotes of
T22916 36942-36945 DT denotes the
T22918 36946-36949 CD denotes six
T22919 36950-36960 JJ denotes individual
T22920 36961-36966 NN denotes donor
T22917 36967-36974 NNS denotes regions
T22921 36975-36978 CC denotes and
T22922 36979-36991 JJ denotes heterozygous
T22923 36992-36996 NNS denotes mice
T22925 36997-37001 VBD denotes were
T22924 37002-37012 VBN denotes intermated
T22926 37013-37014 -LRB- denotes (
T22927 37014-37020 NN denotes Figure
T22928 37021-37022 CD denotes 1
T22929 37022-37023 -RRB- denotes )
T22930 37023-37024 . denotes .
T22931 37024-37113 sentence denotes Homozygous HG.CAST speed congenic strains were maintained through brother-sister mating.
T22932 37025-37035 JJ denotes Homozygous
T22934 37036-37043 NN denotes HG.CAST
T22935 37044-37049 NN denotes speed
T22936 37050-37058 JJ denotes congenic
T22933 37059-37066 NNS denotes strains
T22938 37067-37071 VBD denotes were
T22937 37072-37082 VBN denotes maintained
T22939 37083-37090 IN denotes through
T22940 37091-37098 NN denotes brother
T22942 37098-37099 HYPH denotes -
T22941 37099-37105 NN denotes sister
T22943 37106-37112 NN denotes mating
T22944 37112-37113 . denotes .
T22945 37113-37278 sentence denotes Once each congenic was stabilized, 19 additional microsatellite markers were used to refine the position of each congenic recombinant end point (Additional File 2).
T22946 37114-37118 IN denotes Once
T22948 37119-37123 DT denotes each
T22949 37124-37132 JJ denotes congenic
T22950 37133-37136 VBD denotes was
T22947 37137-37147 VBN denotes stabilized
T22952 37147-37149 , denotes ,
T22953 37149-37151 CD denotes 19
T22955 37152-37162 JJ denotes additional
T22956 37163-37177 NN denotes microsatellite
T22954 37178-37185 NNS denotes markers
T22957 37186-37190 VBD denotes were
T22951 37191-37195 VBN denotes used
T22958 37196-37198 TO denotes to
T22959 37199-37205 VB denotes refine
T22960 37206-37209 DT denotes the
T22961 37210-37218 NN denotes position
T22962 37219-37221 IN denotes of
T22963 37222-37226 DT denotes each
T22965 37227-37235 JJ denotes congenic
T22966 37236-37247 JJ denotes recombinant
T22967 37248-37251 NN denotes end
T22964 37252-37257 NN denotes point
T22968 37258-37259 -LRB- denotes (
T22970 37259-37269 JJ denotes Additional
T22969 37270-37274 NN denotes File
T22971 37275-37276 CD denotes 2
T22972 37276-37277 -RRB- denotes )
T22973 37277-37278 . denotes .
T23420 37280-37291 NN denotes Development
T23421 37292-37294 IN denotes of
T23422 37295-37303 NN denotes B6.CASTC
T23424 37304-37307 CC denotes and
T23425 37308-37316 NN denotes HG.CASTC
T23426 37317-37324 NN denotes control
T23423 37325-37332 NNS denotes strains
T23427 37332-37655 sentence denotes HG is a strain in which the hg deletion has been introgressed onto a B6 background, therefore the only genetic differences between the strains would be the hg locus, tightly linked alleles from the outbred strain on which hg arose and contaminating alleles remaining after the nine backcrosses and fixed during inbreeding.
T23428 37333-37335 NN denotes HG
T23429 37336-37338 VBZ denotes is
T23431 37339-37340 DT denotes a
T23432 37341-37347 NN denotes strain
T23433 37348-37350 IN denotes in
T23435 37351-37356 WDT denotes which
T23436 37357-37360 DT denotes the
T23438 37361-37363 NN denotes hg
T23437 37364-37372 NN denotes deletion
T23439 37373-37376 VBZ denotes has
T23440 37377-37381 VBN denotes been
T23434 37382-37394 VBN denotes introgressed
T23441 37395-37399 IN denotes onto
T23442 37400-37401 DT denotes a
T23444 37402-37404 NN denotes B6
T23443 37405-37415 NN denotes background
T23445 37415-37417 , denotes ,
T23446 37417-37426 RB denotes therefore
T23447 37427-37430 DT denotes the
T23449 37431-37435 JJ denotes only
T23450 37436-37443 JJ denotes genetic
T23448 37444-37455 NNS denotes differences
T23451 37456-37463 IN denotes between
T23452 37464-37467 DT denotes the
T23453 37468-37475 NNS denotes strains
T23454 37476-37481 MD denotes would
T23430 37482-37484 VB denotes be
T23455 37485-37488 DT denotes the
T23457 37489-37491 NN denotes hg
T23456 37492-37497 NN denotes locus
T23458 37497-37499 , denotes ,
T23459 37499-37506 RB denotes tightly
T23460 37507-37513 VBN denotes linked
T23461 37514-37521 NNS denotes alleles
T23462 37522-37526 IN denotes from
T23463 37527-37530 DT denotes the
T23465 37531-37538 VBN denotes outbred
T23464 37539-37545 NN denotes strain
T23466 37546-37548 IN denotes on
T23468 37549-37554 WDT denotes which
T23469 37555-37557 NN denotes hg
T23467 37558-37563 VBD denotes arose
T23470 37564-37567 CC denotes and
T23471 37568-37581 VBG denotes contaminating
T23472 37582-37589 NNS denotes alleles
T23473 37590-37599 VBG denotes remaining
T23474 37600-37605 IN denotes after
T23475 37606-37609 DT denotes the
T23477 37610-37614 CD denotes nine
T23476 37615-37626 NNS denotes backcrosses
T23478 37627-37630 CC denotes and
T23479 37631-37636 VBN denotes fixed
T23480 37637-37643 IN denotes during
T23481 37644-37654 NN denotes inbreeding
T23482 37654-37655 . denotes .
T23483 37655-37869 sentence denotes Instead of using parental B6 and HG strains as controls for phenotypic comparisons with each speed congenic, we choose to develop independent control strains originating from the same cross as the congenic panels.
T23484 37656-37663 RB denotes Instead
T23485 37664-37666 IN denotes of
T23487 37667-37672 VBG denotes using
T23488 37673-37681 JJ denotes parental
T23490 37682-37684 NN denotes B6
T23491 37685-37688 CC denotes and
T23492 37689-37691 NN denotes HG
T23489 37692-37699 NNS denotes strains
T23493 37700-37702 IN denotes as
T23494 37703-37711 NNS denotes controls
T23495 37712-37715 IN denotes for
T23496 37716-37726 JJ denotes phenotypic
T23497 37727-37738 NNS denotes comparisons
T23498 37739-37743 IN denotes with
T23499 37744-37748 DT denotes each
T23500 37749-37754 NN denotes speed
T23501 37755-37763 JJ denotes congenic
T23502 37763-37765 , denotes ,
T23503 37765-37767 PRP denotes we
T23486 37768-37774 VBP denotes choose
T23504 37775-37777 TO denotes to
T23505 37778-37785 VB denotes develop
T23506 37786-37797 JJ denotes independent
T23508 37798-37805 NN denotes control
T23507 37806-37813 NNS denotes strains
T23509 37814-37825 VBG denotes originating
T23510 37826-37830 IN denotes from
T23511 37831-37834 DT denotes the
T23513 37835-37839 JJ denotes same
T23512 37840-37845 NN denotes cross
T23514 37846-37848 IN denotes as
T23515 37849-37852 DT denotes the
T23517 37853-37861 JJ denotes congenic
T23516 37862-37868 NNS denotes panels
T23518 37868-37869 . denotes .
T23519 37869-37986 sentence denotes Separate B6.CAST control (B6C) and HG.CAST control (HGC) strains were developed using mice from the MMU2 experiment.
T23520 37870-37878 JJ denotes Separate
T23522 37879-37886 NN denotes B6.CAST
T23523 37887-37894 NN denotes control
T23524 37895-37896 -LRB- denotes (
T23525 37896-37899 NN denotes B6C
T23526 37899-37900 -RRB- denotes )
T23527 37901-37904 CC denotes and
T23528 37905-37912 NN denotes HG.CAST
T23529 37913-37920 NN denotes control
T23530 37921-37922 -LRB- denotes (
T23531 37922-37925 NN denotes HGC
T23532 37925-37926 -RRB- denotes )
T23521 37927-37934 NNS denotes strains
T23534 37935-37939 VBD denotes were
T23533 37940-37949 VBN denotes developed
T23535 37950-37955 VBG denotes using
T23536 37956-37960 NNS denotes mice
T23537 37961-37965 IN denotes from
T23538 37966-37969 DT denotes the
T23540 37970-37974 NN denotes MMU2
T23539 37975-37985 NN denotes experiment
T23541 37985-37986 . denotes .
T23542 37986-38134 sentence denotes Mice from the last backcross inheriting only B6 or HG MMU2 alleles at markers spanning MMU2 were intermated to serve as the basis for each control.
T23543 37987-37991 NNS denotes Mice
T23545 37992-37996 IN denotes from
T23546 37997-38000 DT denotes the
T23548 38001-38005 JJ denotes last
T23547 38006-38015 NN denotes backcross
T23549 38016-38026 VBG denotes inheriting
T23550 38027-38031 RB denotes only
T23552 38032-38034 NN denotes B6
T23553 38035-38037 CC denotes or
T23554 38038-38040 NN denotes HG
T23555 38041-38045 NN denotes MMU2
T23551 38046-38053 NNS denotes alleles
T23556 38054-38056 IN denotes at
T23557 38057-38064 NNS denotes markers
T23558 38065-38073 VBG denotes spanning
T23559 38074-38078 NN denotes MMU2
T23560 38079-38083 VBD denotes were
T23544 38084-38094 VBN denotes intermated
T23561 38095-38097 TO denotes to
T23562 38098-38103 VB denotes serve
T23563 38104-38106 IN denotes as
T23564 38107-38110 DT denotes the
T23565 38111-38116 NN denotes basis
T23566 38117-38120 IN denotes for
T23567 38121-38125 DT denotes each
T23568 38126-38133 NN denotes control
T23569 38133-38134 . denotes .
T23570 38134-38215 sentence denotes Both control strains were subsequently maintained through brother-sister mating.
T23571 38135-38139 DT denotes Both
T23573 38140-38147 NN denotes control
T23572 38148-38155 NNS denotes strains
T23575 38156-38160 VBD denotes were
T23576 38161-38173 RB denotes subsequently
T23574 38174-38184 VBN denotes maintained
T23577 38185-38192 IN denotes through
T23578 38193-38200 NN denotes brother
T23580 38200-38201 HYPH denotes -
T23579 38201-38207 NN denotes sister
T23581 38208-38214 NN denotes mating
T23582 38214-38215 . denotes .
T23583 38215-38439 sentence denotes The control strains were coisogenic with the parental B6 or HG strain with the exception of mutations that arose during congenic construction and a small percentage of contaminating donor alleles missed after 6 backcrosses.
T23584 38216-38219 DT denotes The
T23586 38220-38227 NN denotes control
T23585 38228-38235 NNS denotes strains
T23587 38236-38240 VBD denotes were
T23588 38241-38251 JJ denotes coisogenic
T23589 38252-38256 IN denotes with
T23590 38257-38260 DT denotes the
T23592 38261-38269 JJ denotes parental
T23593 38270-38272 NN denotes B6
T23594 38273-38275 CC denotes or
T23595 38276-38278 NN denotes HG
T23591 38279-38285 NN denotes strain
T23596 38286-38290 IN denotes with
T23597 38291-38294 DT denotes the
T23598 38295-38304 NN denotes exception
T23599 38305-38307 IN denotes of
T23600 38308-38317 NNS denotes mutations
T23601 38318-38322 WDT denotes that
T23602 38323-38328 VBD denotes arose
T23603 38329-38335 IN denotes during
T23604 38336-38344 JJ denotes congenic
T23605 38345-38357 NN denotes construction
T23606 38358-38361 CC denotes and
T23607 38362-38363 DT denotes a
T23609 38364-38369 JJ denotes small
T23608 38370-38380 NN denotes percentage
T23610 38381-38383 IN denotes of
T23611 38384-38397 VBG denotes contaminating
T23613 38398-38403 NN denotes donor
T23612 38404-38411 NNS denotes alleles
T23614 38412-38418 VBN denotes missed
T23615 38419-38424 IN denotes after
T23616 38425-38426 CD denotes 6
T23617 38427-38438 NNS denotes backcrosses
T23618 38438-38439 . denotes .
T23619 38439-38658 sentence denotes Therefore, since the congenics and controls were developed through the same selection scheme and possibly share common contaminating regions, the B6C and HGC strains are the most ideal control to compare each congenic.
T23620 38440-38449 RB denotes Therefore
T23622 38449-38451 , denotes ,
T23623 38451-38456 IN denotes since
T23625 38457-38460 DT denotes the
T23626 38461-38470 NNS denotes congenics
T23627 38471-38474 CC denotes and
T23628 38475-38483 NNS denotes controls
T23629 38484-38488 VBD denotes were
T23624 38489-38498 VBN denotes developed
T23630 38499-38506 IN denotes through
T23631 38507-38510 DT denotes the
T23633 38511-38515 JJ denotes same
T23634 38516-38525 NN denotes selection
T23632 38526-38532 NN denotes scheme
T23635 38533-38536 CC denotes and
T23636 38537-38545 RB denotes possibly
T23637 38546-38551 VBP denotes share
T23638 38552-38558 JJ denotes common
T23640 38559-38572 VBG denotes contaminating
T23639 38573-38580 NNS denotes regions
T23641 38580-38582 , denotes ,
T23642 38582-38585 DT denotes the
T23644 38586-38589 NN denotes B6C
T23645 38590-38593 CC denotes and
T23646 38594-38597 NN denotes HGC
T23643 38598-38605 NNS denotes strains
T23621 38606-38609 VBP denotes are
T23647 38610-38613 DT denotes the
T23649 38614-38618 RBS denotes most
T23650 38619-38624 JJ denotes ideal
T23648 38625-38632 NN denotes control
T23651 38633-38635 TO denotes to
T23652 38636-38643 VB denotes compare
T23653 38644-38648 DT denotes each
T23654 38649-38657 NN denotes congenic
T23655 38657-38658 . denotes .
T24427 38660-38670 JJ denotes Phenotypic
T24428 38671-38687 NN denotes characterization
T24429 38687-38794 sentence denotes Trait data were collected on approximately 40 mice (20 of each sex) from each congenic and control strain.
T24430 38688-38693 NN denotes Trait
T24431 38694-38698 NNS denotes data
T24433 38699-38703 VBD denotes were
T24432 38704-38713 VBN denotes collected
T24434 38714-38716 IN denotes on
T24435 38717-38730 RB denotes approximately
T24436 38731-38733 CD denotes 40
T24437 38734-38738 NNS denotes mice
T24438 38739-38740 -LRB- denotes (
T24439 38740-38742 CD denotes 20
T24440 38743-38745 IN denotes of
T24441 38746-38750 DT denotes each
T24442 38751-38754 NN denotes sex
T24443 38754-38755 -RRB- denotes )
T24444 38756-38760 IN denotes from
T24445 38761-38765 DT denotes each
T24447 38766-38774 JJ denotes congenic
T24448 38775-38778 CC denotes and
T24449 38779-38786 NN denotes control
T24446 38787-38793 NN denotes strain
T24450 38793-38794 . denotes .
T24451 38794-38951 sentence denotes To eliminate parity and reduce litter size effects only progeny from uniparous dams were characterized and all litters were standardized to 5–7 pups/litter.
T24452 38795-38797 TO denotes To
T24453 38798-38807 VB denotes eliminate
T24455 38808-38814 NN denotes parity
T24456 38815-38818 CC denotes and
T24457 38819-38825 VB denotes reduce
T24458 38826-38832 NN denotes litter
T24459 38833-38837 NN denotes size
T24460 38838-38845 NNS denotes effects
T24461 38846-38850 RB denotes only
T24462 38851-38858 NN denotes progeny
T24463 38859-38863 IN denotes from
T24464 38864-38873 JJ denotes uniparous
T24465 38874-38878 NNS denotes dams
T24466 38879-38883 VBD denotes were
T24454 38884-38897 VBN denotes characterized
T24467 38898-38901 CC denotes and
T24468 38902-38905 DT denotes all
T24469 38906-38913 NNS denotes litters
T24471 38914-38918 VBD denotes were
T24470 38919-38931 VBN denotes standardized
T24472 38932-38934 IN denotes to
T24473 38935-38936 CD denotes 5
T24475 38936-38937 SYM denotes –
T24474 38937-38938 CD denotes 7
T24476 38939-38943 NNS denotes pups
T24477 38943-38944 SYM denotes /
T24478 38944-38950 NN denotes litter
T24479 38950-38951 . denotes .
T24480 38951-38987 sentence denotes Mice were weaned at 3 weeks of age.
T24481 38952-38956 NNS denotes Mice
T24483 38957-38961 VBD denotes were
T24482 38962-38968 VBN denotes weaned
T24484 38969-38971 IN denotes at
T24485 38972-38973 CD denotes 3
T24486 38974-38979 NNS denotes weeks
T24487 38980-38982 IN denotes of
T24488 38983-38986 NN denotes age
T24489 38986-38987 . denotes .
T24490 38987-39078 sentence denotes Feed (Purina 5008; 23.5% protein, 6.5% fat, 3.3 Kcal/g) and water were offered ad libitum.
T24491 38988-38992 NN denotes Feed
T24493 38993-38994 -LRB- denotes (
T24495 38994-39000 NNP denotes Purina
T24496 39001-39005 CD denotes 5008
T24497 39005-39006 : denotes ;
T24498 39007-39011 CD denotes 23.5
T24499 39011-39012 NN denotes %
T24494 39013-39020 NN denotes protein
T24500 39020-39022 , denotes ,
T24501 39022-39025 CD denotes 6.5
T24502 39025-39026 NN denotes %
T24503 39027-39030 NN denotes fat
T24504 39030-39032 , denotes ,
T24505 39032-39035 CD denotes 3.3
T24506 39036-39040 NN denotes Kcal
T24507 39040-39041 SYM denotes /
T24508 39041-39042 NN denotes g
T24509 39042-39043 -RRB- denotes )
T24510 39044-39047 CC denotes and
T24511 39048-39053 NN denotes water
T24512 39054-39058 VBD denotes were
T24492 39059-39066 VBN denotes offered
T24513 39067-39069 FW denotes ad
T24514 39070-39077 FW denotes libitum
T24515 39077-39078 . denotes .
T24516 39078-39151 sentence denotes Mice were weighed to the nearest 0.1 g at 2WK, 3WK, 6WK, and 9WK of age.
T24517 39079-39083 NNS denotes Mice
T24519 39084-39088 VBD denotes were
T24518 39089-39096 VBN denotes weighed
T24520 39097-39099 IN denotes to
T24521 39100-39103 DT denotes the
T24523 39104-39111 JJS denotes nearest
T24524 39112-39115 CD denotes 0.1
T24522 39116-39117 NN denotes g
T24525 39118-39120 IN denotes at
T24526 39121-39124 NN denotes 2WK
T24527 39124-39126 , denotes ,
T24528 39126-39129 NN denotes 3WK
T24529 39129-39131 , denotes ,
T24530 39131-39134 NN denotes 6WK
T24531 39134-39136 , denotes ,
T24532 39136-39139 CC denotes and
T24533 39140-39143 NN denotes 9WK
T24534 39144-39146 IN denotes of
T24535 39147-39150 NN denotes age
T24536 39150-39151 . denotes .
T24537 39151-39290 sentence denotes At 9WK ( ± 5 days) mice were anesthetized under isoflurane and nasal-anal length (NA) and nasal-tail (NT) were measured to the nearest mm.
T24538 39152-39154 IN denotes At
T24540 39155-39158 NN denotes 9WK
T24541 39159-39160 -LRB- denotes (
T24542 39161-39162 SYM denotes ±
T24543 39163-39164 CD denotes 5
T24544 39165-39169 NNS denotes days
T24545 39169-39170 -RRB- denotes )
T24546 39171-39175 NNS denotes mice
T24547 39176-39180 VBD denotes were
T24539 39181-39193 VBN denotes anesthetized
T24548 39194-39199 IN denotes under
T24549 39200-39210 NN denotes isoflurane
T24550 39211-39214 CC denotes and
T24551 39215-39220 JJ denotes nasal
T24553 39220-39221 HYPH denotes -
T24552 39221-39225 JJ denotes anal
T24554 39226-39232 NN denotes length
T24556 39233-39234 -LRB- denotes (
T24557 39234-39236 NN denotes NA
T24558 39236-39237 -RRB- denotes )
T24559 39238-39241 CC denotes and
T24560 39242-39247 JJ denotes nasal
T24562 39247-39248 HYPH denotes -
T24561 39248-39252 NN denotes tail
T24563 39253-39254 -LRB- denotes (
T24564 39254-39256 NN denotes NT
T24565 39256-39257 -RRB- denotes )
T24566 39258-39262 VBD denotes were
T24555 39263-39271 VBN denotes measured
T24567 39272-39274 IN denotes to
T24568 39275-39278 DT denotes the
T24570 39279-39286 JJS denotes nearest
T24569 39287-39289 NN denotes mm
T24571 39289-39290 . denotes .
T24572 39290-39333 sentence denotes Tail length was calculated as NA minus NT.
T24573 39291-39295 NN denotes Tail
T24574 39296-39302 NN denotes length
T24576 39303-39306 VBD denotes was
T24575 39307-39317 VBN denotes calculated
T24577 39318-39320 IN denotes as
T24578 39321-39323 NN denotes NA
T24579 39324-39329 CC denotes minus
T24580 39330-39332 NN denotes NT
T24581 39332-39333 . denotes .
T24582 39333-39407 sentence denotes Anesthetized mice were then sacrificed by decapitation and exsanguinated.
T24583 39334-39346 VBN denotes Anesthetized
T24584 39347-39351 NNS denotes mice
T24586 39352-39356 VBD denotes were
T24587 39357-39361 RB denotes then
T24585 39362-39372 VBN denotes sacrificed
T24588 39373-39375 IN denotes by
T24589 39376-39388 NN denotes decapitation
T24590 39389-39392 CC denotes and
T24591 39393-39406 VBN denotes exsanguinated
T24592 39406-39407 . denotes .
T24593 39407-39556 sentence denotes Femoral fat pad (FFP), gonadal fat pad (GFP), mesenteric fat pad (MFP) and retroperitoneal fat pad (RFP) were removed and weighed to the nearest mg.
T24594 39408-39415 JJ denotes Femoral
T24596 39416-39419 NN denotes fat
T24595 39420-39423 NN denotes pad
T24598 39424-39425 -LRB- denotes (
T24599 39425-39428 NN denotes FFP
T24600 39428-39429 -RRB- denotes )
T24601 39429-39431 , denotes ,
T24602 39431-39438 JJ denotes gonadal
T24604 39439-39442 NN denotes fat
T24603 39443-39446 NN denotes pad
T24605 39447-39448 -LRB- denotes (
T24606 39448-39451 NN denotes GFP
T24607 39451-39452 -RRB- denotes )
T24608 39452-39454 , denotes ,
T24609 39454-39464 JJ denotes mesenteric
T24611 39465-39468 NN denotes fat
T24610 39469-39472 NN denotes pad
T24612 39473-39474 -LRB- denotes (
T24613 39474-39477 NN denotes MFP
T24614 39477-39478 -RRB- denotes )
T24615 39479-39482 CC denotes and
T24616 39483-39498 JJ denotes retroperitoneal
T24618 39499-39502 NN denotes fat
T24617 39503-39506 NN denotes pad
T24619 39507-39508 -LRB- denotes (
T24620 39508-39511 NN denotes RFP
T24621 39511-39512 -RRB- denotes )
T24622 39513-39517 VBD denotes were
T24597 39518-39525 VBN denotes removed
T24623 39526-39529 CC denotes and
T24624 39530-39537 VBN denotes weighed
T24625 39538-39540 IN denotes to
T24626 39541-39544 DT denotes the
T24628 39545-39552 JJS denotes nearest
T24627 39553-39555 NN denotes mg
T24629 39555-39556 . denotes .
T24630 39556-39691 sentence denotes Chemical compositional analysis was performed for HGC, HG11 and HG17 carcasses as previously described with slight modifications [24].
T24631 39557-39565 JJ denotes Chemical
T24633 39566-39579 JJ denotes compositional
T24632 39580-39588 NN denotes analysis
T24635 39589-39592 VBD denotes was
T24634 39593-39602 VBN denotes performed
T24636 39603-39606 IN denotes for
T24637 39607-39610 NN denotes HGC
T24639 39610-39612 , denotes ,
T24640 39612-39616 NN denotes HG11
T24641 39617-39620 CC denotes and
T24642 39621-39625 NN denotes HG17
T24638 39626-39635 NNS denotes carcasses
T24643 39636-39638 IN denotes as
T24645 39639-39649 RB denotes previously
T24644 39650-39659 VBN denotes described
T24646 39660-39664 IN denotes with
T24647 39665-39671 JJ denotes slight
T24648 39672-39685 NNS denotes modifications
T24649 39686-39687 -LRB- denotes [
T24650 39687-39689 CD denotes 24
T24651 39689-39690 -RRB- denotes ]
T24652 39690-39691 . denotes .
T24653 39691-39757 sentence denotes Briefly, after weighing each fat pad was returned to the carcass.
T24654 39692-39699 RB denotes Briefly
T24656 39699-39701 , denotes ,
T24657 39701-39706 IN denotes after
T24658 39707-39715 VBG denotes weighing
T24659 39716-39720 DT denotes each
T24661 39721-39724 NN denotes fat
T24660 39725-39728 NN denotes pad
T24662 39729-39732 VBD denotes was
T24655 39733-39741 VBN denotes returned
T24663 39742-39744 IN denotes to
T24664 39745-39748 DT denotes the
T24665 39749-39756 NN denotes carcass
T24666 39756-39757 . denotes .
T24667 39757-39855 sentence denotes The entire gastrointestinal (GI) tract was subsequently removed and carcasses were again weighed.
T24668 39758-39761 DT denotes The
T24670 39762-39768 JJ denotes entire
T24671 39769-39785 JJ denotes gastrointestinal
T24672 39786-39787 -LRB- denotes (
T24673 39787-39789 NN denotes GI
T24674 39789-39790 -RRB- denotes )
T24669 39791-39796 NN denotes tract
T24676 39797-39800 VBD denotes was
T24677 39801-39813 RB denotes subsequently
T24675 39814-39821 VBN denotes removed
T24678 39822-39825 CC denotes and
T24679 39826-39835 NNS denotes carcasses
T24681 39836-39840 VBD denotes were
T24682 39841-39846 RB denotes again
T24680 39847-39854 VBN denotes weighed
T24683 39854-39855 . denotes .
T24684 39855-39904 sentence denotes This represented the empty carcass weight (ECW).
T24685 39856-39860 DT denotes This
T24686 39861-39872 VBD denotes represented
T24687 39873-39876 DT denotes the
T24689 39877-39882 JJ denotes empty
T24690 39883-39890 NN denotes carcass
T24688 39891-39897 NN denotes weight
T24691 39898-39899 -LRB- denotes (
T24692 39899-39902 NN denotes ECW
T24693 39902-39903 -RRB- denotes )
T24694 39903-39904 . denotes .
T24695 39904-40013 sentence denotes Carcasses were labeled and secured in two layers of cheesecloth (Fisher) and frozen at -20°C until analysis.
T24696 39905-39914 NNS denotes Carcasses
T24698 39915-39919 VBD denotes were
T24697 39920-39927 VBN denotes labeled
T24699 39928-39931 CC denotes and
T24700 39932-39939 VBN denotes secured
T24701 39940-39942 IN denotes in
T24702 39943-39946 CD denotes two
T24703 39947-39953 NNS denotes layers
T24704 39954-39956 IN denotes of
T24705 39957-39968 NN denotes cheesecloth
T24706 39969-39970 -LRB- denotes (
T24707 39970-39976 NNP denotes Fisher
T24708 39976-39977 -RRB- denotes )
T24709 39978-39981 CC denotes and
T24710 39982-39988 VBN denotes frozen
T24711 39989-39991 IN denotes at
T24712 39992-39993 SYM denotes -
T24713 39993-39995 CD denotes 20
T24714 39995-39997 NN denotes °C
T24715 39998-40003 IN denotes until
T24716 40004-40012 NN denotes analysis
T24717 40012-40013 . denotes .
T24718 40013-40152 sentence denotes At this time, carcasses were freeze-dried for seven days and water content was determined by subtracting the freeze-dried weight from ECW.
T24719 40014-40016 IN denotes At
T24721 40017-40021 DT denotes this
T24722 40022-40026 NN denotes time
T24723 40026-40028 , denotes ,
T24724 40028-40037 NNS denotes carcasses
T24725 40038-40042 VBD denotes were
T24726 40043-40049 NN denotes freeze
T24727 40049-40050 HYPH denotes -
T24720 40050-40055 VBN denotes dried
T24728 40056-40059 IN denotes for
T24729 40060-40065 CD denotes seven
T24730 40066-40070 NNS denotes days
T24731 40071-40074 CC denotes and
T24732 40075-40080 NN denotes water
T24733 40081-40088 NN denotes content
T24735 40089-40092 VBD denotes was
T24734 40093-40103 VBN denotes determined
T24736 40104-40106 IN denotes by
T24737 40107-40118 VBG denotes subtracting
T24738 40119-40122 DT denotes the
T24740 40123-40129 NN denotes freeze
T24742 40129-40130 HYPH denotes -
T24741 40130-40135 VBN denotes dried
T24739 40136-40142 NN denotes weight
T24743 40143-40147 IN denotes from
T24744 40148-40151 NNP denotes ECW
T24745 40151-40152 . denotes .
T24746 40152-40267 sentence denotes FAT was then extracted with ether for 7 days, followed by acetone for an additional 7 days in a Soxhlet apparatus.
T24747 40153-40156 NN denotes FAT
T24749 40157-40160 VBD denotes was
T24750 40161-40165 RB denotes then
T24751 40166-40175 VBN denotes extracted
T24752 40176-40180 IN denotes with
T24753 40181-40186 NN denotes ether
T24754 40187-40190 IN denotes for
T24755 40191-40192 CD denotes 7
T24756 40193-40197 NNS denotes days
T24757 40197-40199 , denotes ,
T24748 40199-40207 VBN denotes followed
T24758 40208-40210 IN denotes by
T24759 40211-40218 NN denotes acetone
T24760 40219-40222 IN denotes for
T24761 40223-40225 DT denotes an
T24763 40226-40236 JJ denotes additional
T24764 40237-40238 CD denotes 7
T24762 40239-40243 NNS denotes days
T24765 40244-40246 IN denotes in
T24766 40247-40248 DT denotes a
T24768 40249-40256 NNP denotes Soxhlet
T24767 40257-40266 NN denotes apparatus
T24769 40266-40267 . denotes .
T24770 40267-40361 sentence denotes Carcass ash (ASH) was determined measuring the remains after a 16 hour incineration at 575°C.
T24771 40268-40275 NN denotes Carcass
T24772 40276-40279 NN denotes ash
T24774 40280-40281 -LRB- denotes (
T24775 40281-40284 NN denotes ASH
T24776 40284-40285 -RRB- denotes )
T24777 40286-40289 VBD denotes was
T24773 40290-40300 VBN denotes determined
T24778 40301-40310 VBG denotes measuring
T24779 40311-40314 DT denotes the
T24780 40315-40322 NNS denotes remains
T24781 40323-40328 IN denotes after
T24782 40329-40330 DT denotes a
T24784 40331-40333 CD denotes 16
T24785 40334-40338 NN denotes hour
T24783 40339-40351 NN denotes incineration
T24786 40352-40354 IN denotes at
T24787 40355-40358 CD denotes 575
T24788 40358-40360 NN denotes °C
T24789 40360-40361 . denotes .
T24790 40361-40482 sentence denotes Carcass protein (PROT) was calculated as the remaining portion after carcass fat (FAT) and ASH were subtracted from ECW.
T24791 40362-40369 NN denotes Carcass
T24792 40370-40377 NN denotes protein
T24794 40378-40379 -LRB- denotes (
T24795 40379-40383 NN denotes PROT
T24796 40383-40384 -RRB- denotes )
T24797 40385-40388 VBD denotes was
T24793 40389-40399 VBN denotes calculated
T24798 40400-40402 IN denotes as
T24799 40403-40406 DT denotes the
T24801 40407-40416 VBG denotes remaining
T24800 40417-40424 NN denotes portion
T24802 40425-40430 IN denotes after
T24804 40431-40438 NN denotes carcass
T24805 40439-40442 NN denotes fat
T24806 40443-40444 -LRB- denotes (
T24807 40444-40447 NN denotes FAT
T24808 40447-40448 -RRB- denotes )
T24809 40449-40452 CC denotes and
T24810 40453-40456 NN denotes ASH
T24811 40457-40461 VBD denotes were
T24803 40462-40472 VBN denotes subtracted
T24812 40473-40477 IN denotes from
T24813 40478-40481 NN denotes ECW
T24814 40481-40482 . denotes .
T25106 40484-40495 JJ denotes Statistical
T25107 40496-40504 NN denotes analysis
T25108 40504-40644 sentence denotes The MEANS and UNIVARIATE procedures of SAS were used to generate descriptive statistics and test normality assumptions for each trait [55].
T25109 40505-40508 DT denotes The
T25111 40509-40514 NN denotes MEANS
T25112 40515-40518 CC denotes and
T25113 40519-40529 NN denotes UNIVARIATE
T25110 40530-40540 NNS denotes procedures
T25115 40541-40543 IN denotes of
T25116 40544-40547 NNP denotes SAS
T25117 40548-40552 VBD denotes were
T25114 40553-40557 VBN denotes used
T25118 40558-40560 TO denotes to
T25119 40561-40569 VB denotes generate
T25120 40570-40581 JJ denotes descriptive
T25121 40582-40592 NNS denotes statistics
T25122 40593-40596 CC denotes and
T25123 40597-40601 VB denotes test
T25124 40602-40611 NN denotes normality
T25125 40612-40623 NNS denotes assumptions
T25126 40624-40627 IN denotes for
T25127 40628-40632 DT denotes each
T25128 40633-40638 NN denotes trait
T25129 40639-40640 -LRB- denotes [
T25130 40640-40642 CD denotes 55
T25131 40642-40643 -RRB- denotes ]
T25132 40643-40644 . denotes .
T25133 40644-40866 sentence denotes All data were then analyzed using the GLM procedure of SAS [55] with a linear model that included the fixed effects of strain, sex and strain by sex interaction; dam's weight at breeding by strain was used as a covariate.
T25134 40645-40648 DT denotes All
T25135 40649-40653 NNS denotes data
T25137 40654-40658 VBD denotes were
T25138 40659-40663 RB denotes then
T25136 40664-40672 VBN denotes analyzed
T25140 40673-40678 VBG denotes using
T25141 40679-40682 DT denotes the
T25143 40683-40686 NN denotes GLM
T25142 40687-40696 NN denotes procedure
T25144 40697-40699 IN denotes of
T25145 40700-40703 NN denotes SAS
T25146 40704-40705 -LRB- denotes [
T25147 40705-40707 CD denotes 55
T25148 40707-40708 -RRB- denotes ]
T25149 40709-40713 IN denotes with
T25150 40714-40715 DT denotes a
T25152 40716-40722 JJ denotes linear
T25151 40723-40728 NN denotes model
T25153 40729-40733 WDT denotes that
T25154 40734-40742 VBD denotes included
T25155 40743-40746 DT denotes the
T25157 40747-40752 VBN denotes fixed
T25156 40753-40760 NNS denotes effects
T25158 40761-40763 IN denotes of
T25159 40764-40770 NN denotes strain
T25160 40770-40772 , denotes ,
T25161 40772-40775 NN denotes sex
T25162 40776-40779 CC denotes and
T25163 40780-40786 NN denotes strain
T25165 40787-40789 IN denotes by
T25166 40790-40793 NN denotes sex
T25164 40794-40805 NN denotes interaction
T25167 40805-40806 : denotes ;
T25168 40807-40810 NN denotes dam
T25170 40810-40812 POS denotes 's
T25169 40813-40819 NN denotes weight
T25171 40820-40822 IN denotes at
T25172 40823-40831 NN denotes breeding
T25173 40832-40834 IN denotes by
T25174 40835-40841 NN denotes strain
T25175 40842-40845 VBD denotes was
T25139 40846-40850 VBN denotes used
T25176 40851-40853 IN denotes as
T25177 40854-40855 DT denotes a
T25178 40856-40865 NN denotes covariate
T25179 40865-40866 . denotes .
T25180 40866-40960 sentence denotes A second linear model was used to test for strain by hg genotype (+/+ or hg/hg) interactions.
T25181 40867-40868 DT denotes A
T25183 40869-40875 JJ denotes second
T25184 40876-40882 JJ denotes linear
T25182 40883-40888 NN denotes model
T25186 40889-40892 VBD denotes was
T25185 40893-40897 VBN denotes used
T25187 40898-40900 TO denotes to
T25188 40901-40905 VB denotes test
T25189 40906-40909 IN denotes for
T25190 40910-40916 NN denotes strain
T25192 40917-40919 IN denotes by
T25193 40920-40922 NN denotes hg
T25194 40923-40931 NN denotes genotype
T25195 40932-40933 -LRB- denotes (
T25197 40933-40934 SYM denotes +
T25198 40934-40935 HYPH denotes /
T25196 40935-40936 SYM denotes +
T25199 40937-40939 CC denotes or
T25200 40940-40942 NN denotes hg
T25202 40942-40943 HYPH denotes /
T25201 40943-40945 NN denotes hg
T25203 40945-40946 -RRB- denotes )
T25191 40947-40959 NNS denotes interactions
T25204 40959-40960 . denotes .
T25205 40960-41084 sentence denotes This model included the fixed effects of donor region, sex and HG genotype and all possible two and three-way interactions.
T25206 40961-40965 DT denotes This
T25207 40966-40971 NN denotes model
T25208 40972-40980 VBD denotes included
T25209 40981-40984 DT denotes the
T25211 40985-40990 VBN denotes fixed
T25210 40991-40998 NNS denotes effects
T25212 40999-41001 IN denotes of
T25213 41002-41007 NN denotes donor
T25214 41008-41014 NN denotes region
T25215 41014-41016 , denotes ,
T25216 41016-41019 NN denotes sex
T25217 41020-41023 CC denotes and
T25218 41024-41026 NN denotes HG
T25219 41027-41035 NN denotes genotype
T25220 41036-41039 CC denotes and
T25221 41040-41043 DT denotes all
T25223 41044-41052 JJ denotes possible
T25224 41053-41056 CD denotes two
T25226 41057-41060 CC denotes and
T25227 41061-41066 CD denotes three
T25228 41066-41067 HYPH denotes -
T25225 41067-41070 NN denotes way
T25222 41071-41083 NNS denotes interactions
T25229 41083-41084 . denotes .
T25230 41084-41235 sentence denotes Choosing a nominal P value of 0.05 and applying the Bonferroni correction for multiple comparisons established significant differences in the ANOVA's.
T25231 41085-41093 VBG denotes Choosing
T25233 41094-41095 DT denotes a
T25235 41096-41103 JJ denotes nominal
T25236 41104-41105 NN denotes P
T25234 41106-41111 NN denotes value
T25237 41112-41114 IN denotes of
T25238 41115-41119 CD denotes 0.05
T25239 41120-41123 CC denotes and
T25240 41124-41132 VBG denotes applying
T25241 41133-41136 DT denotes the
T25243 41137-41147 NNP denotes Bonferroni
T25242 41148-41158 NN denotes correction
T25244 41159-41162 IN denotes for
T25245 41163-41171 JJ denotes multiple
T25246 41172-41183 NNS denotes comparisons
T25232 41184-41195 VBD denotes established
T25247 41196-41207 JJ denotes significant
T25248 41208-41219 NNS denotes differences
T25249 41220-41222 IN denotes in
T25250 41223-41226 DT denotes the
T25251 41227-41232 NNP denotes ANOVA
T25252 41232-41234 AFX denotes 's
T25253 41234-41235 . denotes .
T25254 41235-41291 sentence denotes The critical P values used are indicated in each table.
T25255 41236-41239 DT denotes The
T25257 41240-41248 JJ denotes critical
T25258 41249-41250 NN denotes P
T25256 41251-41257 NNS denotes values
T25260 41258-41262 VBN denotes used
T25261 41263-41266 VBP denotes are
T25259 41267-41276 VBN denotes indicated
T25262 41277-41279 IN denotes in
T25263 41280-41284 DT denotes each
T25264 41285-41290 NN denotes table
T25265 41290-41291 . denotes .
T25440 41293-41307 NN denotes Identification
T25441 41308-41310 IN denotes of
T25442 41311-41320 NN denotes candidate
T25443 41321-41326 NNS denotes genes
T25444 41326-41420 sentence denotes Genes were identified by manual data mining of primary literature, reviews and book chapters.
T25445 41327-41332 NNS denotes Genes
T25447 41333-41337 VBD denotes were
T25446 41338-41348 VBN denotes identified
T25448 41349-41351 IN denotes by
T25449 41352-41358 JJ denotes manual
T25451 41359-41363 NNS denotes data
T25450 41364-41370 NN denotes mining
T25452 41371-41373 IN denotes of
T25453 41374-41381 JJ denotes primary
T25454 41382-41392 NN denotes literature
T25455 41392-41394 , denotes ,
T25456 41394-41401 NNS denotes reviews
T25457 41402-41405 CC denotes and
T25458 41406-41410 NN denotes book
T25459 41411-41419 NNS denotes chapters
T25460 41419-41420 . denotes .
T25461 41420-41601 sentence denotes To organize and collate genomic and functional information for each gene we created a custom Gh signaling Gene Map Annotator and Pathway Profiler (GenMAPP) pathway [56] (Figure 5).
T25462 41421-41423 TO denotes To
T25463 41424-41432 VB denotes organize
T25465 41433-41436 CC denotes and
T25466 41437-41444 VB denotes collate
T25467 41445-41452 JJ denotes genomic
T25469 41453-41456 CC denotes and
T25470 41457-41467 JJ denotes functional
T25468 41468-41479 NN denotes information
T25471 41480-41483 IN denotes for
T25472 41484-41488 DT denotes each
T25473 41489-41493 NN denotes gene
T25474 41494-41496 PRP denotes we
T25464 41497-41504 VBD denotes created
T25475 41505-41506 DT denotes a
T25477 41507-41513 NN denotes custom
T25478 41514-41516 NN denotes Gh
T25479 41517-41526 NN denotes signaling
T25480 41527-41531 NN denotes Gene
T25481 41532-41535 NN denotes Map
T25476 41536-41545 NN denotes Annotator
T25482 41546-41549 CC denotes and
T25483 41550-41557 NN denotes Pathway
T25484 41558-41566 NN denotes Profiler
T25486 41567-41568 -LRB- denotes (
T25487 41568-41575 NNP denotes GenMAPP
T25488 41575-41576 -RRB- denotes )
T25485 41577-41584 NN denotes pathway
T25489 41585-41586 -LRB- denotes [
T25490 41586-41588 CD denotes 56
T25491 41588-41589 -RRB- denotes ]
T25492 41590-41591 -LRB- denotes (
T25493 41591-41597 NN denotes Figure
T25494 41598-41599 CD denotes 5
T25495 41599-41600 -RRB- denotes )
T25496 41600-41601 . denotes .
T25497 41601-41744 sentence denotes Visualization and color-coding of genes using GenMAPP aided the selection of candidate genes mapping within QTL regions on MMU2, 9, 11 and 17.
T25498 41602-41615 NN denotes Visualization
T25500 41616-41619 CC denotes and
T25501 41620-41625 NN denotes color
T25502 41625-41626 HYPH denotes -
T25503 41626-41632 VBG denotes coding
T25504 41633-41635 IN denotes of
T25505 41636-41641 NNS denotes genes
T25506 41642-41647 VBG denotes using
T25507 41648-41655 NNP denotes GenMAPP
T25499 41656-41661 VBD denotes aided
T25508 41662-41665 DT denotes the
T25509 41666-41675 NN denotes selection
T25510 41676-41678 IN denotes of
T25511 41679-41688 NN denotes candidate
T25512 41689-41694 NNS denotes genes
T25513 41695-41702 VBG denotes mapping
T25514 41703-41709 IN denotes within
T25515 41710-41713 NNS denotes QTL
T25516 41714-41721 NNS denotes regions
T25517 41722-41724 IN denotes on
T25518 41725-41728 NN denotes MMU
T25519 41728-41729 CD denotes 2
T25520 41729-41731 , denotes ,
T25521 41731-41732 CD denotes 9
T25522 41732-41734 , denotes ,
T25523 41734-41736 CD denotes 11
T25524 41737-41740 CC denotes and
T25525 41741-41743 CD denotes 17
T25526 41743-41744 . denotes .
T26350 41746-41755 NN denotes Candidate
T26351 41756-41760 NN denotes gene
T26352 41761-41771 NN denotes sequencing
T26353 41771-42010 sentence denotes PCR amplicons covering the coding sequence and partial 5' and 3' untranslated regions for each selected candidate gene were amplified, purified and sequenced from the CAST strain using protocols outlined in [57] with slight modifications.
T26354 41772-41775 NN denotes PCR
T26355 41776-41785 NNS denotes amplicons
T26357 41786-41794 VBG denotes covering
T26358 41795-41798 DT denotes the
T26360 41799-41805 NN denotes coding
T26359 41806-41814 NN denotes sequence
T26361 41815-41818 CC denotes and
T26362 41819-41826 JJ denotes partial
T26364 41827-41828 CD denotes 5
T26365 41828-41829 SYM denotes '
T26366 41830-41833 CC denotes and
T26367 41834-41835 CD denotes 3
T26368 41835-41836 SYM denotes '
T26369 41837-41849 JJ denotes untranslated
T26363 41850-41857 NNS denotes regions
T26370 41858-41861 IN denotes for
T26371 41862-41866 DT denotes each
T26373 41867-41875 VBN denotes selected
T26374 41876-41885 NN denotes candidate
T26372 41886-41890 NN denotes gene
T26375 41891-41895 VBD denotes were
T26356 41896-41905 VBN denotes amplified
T26376 41905-41907 , denotes ,
T26377 41907-41915 VBN denotes purified
T26378 41916-41919 CC denotes and
T26379 41920-41929 VBN denotes sequenced
T26380 41930-41934 IN denotes from
T26381 41935-41938 DT denotes the
T26383 41939-41943 NN denotes CAST
T26382 41944-41950 NN denotes strain
T26384 41951-41956 VBG denotes using
T26385 41957-41966 NNS denotes protocols
T26386 41967-41975 VBN denotes outlined
T26387 41976-41978 IN denotes in
T26388 41979-41980 -LRB- denotes [
T26389 41980-41982 CD denotes 57
T26390 41982-41983 -RRB- denotes ]
T26391 41984-41988 IN denotes with
T26392 41989-41995 JJ denotes slight
T26393 41996-42009 NNS denotes modifications
T26394 42009-42010 . denotes .
T26395 42010-42129 sentence denotes Total RNA from brain, liver, spleen, lung and testis was isolated from an adult CAST male mouse using Trizol (Ambion).
T26396 42011-42016 JJ denotes Total
T26397 42017-42020 NN denotes RNA
T26399 42021-42025 IN denotes from
T26400 42026-42031 NN denotes brain
T26401 42031-42033 , denotes ,
T26402 42033-42038 NN denotes liver
T26403 42038-42040 , denotes ,
T26404 42040-42046 NN denotes spleen
T26405 42046-42048 , denotes ,
T26406 42048-42052 NN denotes lung
T26407 42053-42056 CC denotes and
T26408 42057-42063 NN denotes testis
T26409 42064-42067 VBD denotes was
T26398 42068-42076 VBN denotes isolated
T26410 42077-42081 IN denotes from
T26411 42082-42084 DT denotes an
T26413 42085-42090 JJ denotes adult
T26414 42091-42095 NN denotes CAST
T26415 42096-42100 JJ denotes male
T26412 42101-42106 NN denotes mouse
T26416 42107-42112 VBG denotes using
T26417 42113-42119 NN denotes Trizol
T26418 42120-42121 -LRB- denotes (
T26419 42121-42127 NNP denotes Ambion
T26420 42127-42128 -RRB- denotes )
T26421 42128-42129 . denotes .
T26422 42129-42189 sentence denotes cDNA was produced from total RNA using standard procedures.
T26423 42130-42134 NN denotes cDNA
T26425 42135-42138 VBD denotes was
T26424 42139-42147 VBN denotes produced
T26426 42148-42152 IN denotes from
T26427 42153-42158 JJ denotes total
T26428 42159-42162 NN denotes RNA
T26429 42163-42168 VBG denotes using
T26430 42169-42177 JJ denotes standard
T26431 42178-42188 NNS denotes procedures
T26432 42188-42189 . denotes .
T26433 42189-42273 sentence denotes PCR primer sets for each gene were designed using Primer3 [58] (Additional File 5).
T26434 42190-42193 NN denotes PCR
T26436 42194-42200 NN denotes primer
T26435 42201-42205 NNS denotes sets
T26438 42206-42209 IN denotes for
T26439 42210-42214 DT denotes each
T26440 42215-42219 NN denotes gene
T26441 42220-42224 VBD denotes were
T26437 42225-42233 VBN denotes designed
T26442 42234-42239 VBG denotes using
T26443 42240-42247 NN denotes Primer3
T26444 42248-42249 -LRB- denotes [
T26445 42249-42251 CD denotes 58
T26446 42251-42252 -RRB- denotes ]
T26447 42253-42254 -LRB- denotes (
T26449 42254-42264 JJ denotes Additional
T26448 42265-42269 NN denotes File
T26450 42270-42271 CD denotes 5
T26451 42271-42272 -RRB- denotes )
T26452 42272-42273 . denotes .
T26453 42273-42409 sentence denotes The initial amplification was performed in 10 μl PCR reactions using the Invitrogen Platinum TaqPCRx amplification system (Invitrogen).
T26454 42274-42277 DT denotes The
T26456 42278-42285 JJ denotes initial
T26455 42286-42299 NN denotes amplification
T26458 42300-42303 VBD denotes was
T26457 42304-42313 VBN denotes performed
T26459 42314-42316 IN denotes in
T26460 42317-42319 CD denotes 10
T26461 42320-42322 NN denotes μl
T26463 42323-42326 NN denotes PCR
T26462 42327-42336 NNS denotes reactions
T26464 42337-42342 VBG denotes using
T26465 42343-42346 DT denotes the
T26467 42347-42357 NNP denotes Invitrogen
T26468 42358-42366 NN denotes Platinum
T26469 42367-42374 NN denotes TaqPCRx
T26470 42375-42388 NN denotes amplification
T26466 42389-42395 NN denotes system
T26471 42396-42397 -LRB- denotes (
T26472 42397-42407 NNP denotes Invitrogen
T26473 42407-42408 -RRB- denotes )
T26474 42408-42409 . denotes .
T26475 42409-42588 sentence denotes The reactions contained 1X PCR buffer, 1X Enhancer solution, 1.5 mM MgSO4, 0.17 mM dNTPs, 1 μM each primer, 0.1 unit of Platinum Taq (Invitrogen) and approximately 25 ng of cDNA.
T26476 42410-42413 DT denotes The
T26477 42414-42423 NNS denotes reactions
T26478 42424-42433 VBD denotes contained
T26479 42434-42436 NN denotes 1X
T26481 42437-42440 NN denotes PCR
T26480 42441-42447 NN denotes buffer
T26482 42447-42449 , denotes ,
T26483 42449-42451 NN denotes 1X
T26485 42452-42460 NN denotes Enhancer
T26484 42461-42469 NN denotes solution
T26486 42469-42471 , denotes ,
T26487 42471-42474 CD denotes 1.5
T26488 42475-42477 NN denotes mM
T26489 42478-42483 NN denotes MgSO4
T26490 42483-42485 , denotes ,
T26491 42485-42489 CD denotes 0.17
T26492 42490-42492 NN denotes mM
T26493 42493-42498 NNS denotes dNTPs
T26494 42498-42500 , denotes ,
T26495 42500-42501 CD denotes 1
T26496 42502-42504 NN denotes μM
T26498 42505-42509 DT denotes each
T26497 42510-42516 NN denotes primer
T26499 42516-42518 , denotes ,
T26500 42518-42521 CD denotes 0.1
T26501 42522-42526 NN denotes unit
T26502 42527-42529 IN denotes of
T26503 42530-42538 NN denotes Platinum
T26504 42539-42542 NN denotes Taq
T26505 42543-42544 -LRB- denotes (
T26506 42544-42554 NNP denotes Invitrogen
T26507 42554-42555 -RRB- denotes )
T26508 42556-42559 CC denotes and
T26509 42560-42573 RB denotes approximately
T26510 42574-42576 CD denotes 25
T26511 42577-42579 NN denotes ng
T26512 42580-42582 IN denotes of
T26513 42583-42587 NN denotes cDNA
T26514 42587-42588 . denotes .
T26515 42588-42769 sentence denotes Reactions were incubated for 5 min at 95°C, then cycled for 45 s at 95°C, 45 s at 55°C, 1 min at 72°C for 35 cycles with a final 72°C extension for 10 min on a MJ Research PTC-200.
T26516 42589-42598 NNS denotes Reactions
T26518 42599-42603 VBD denotes were
T26517 42604-42613 VBN denotes incubated
T26519 42614-42617 IN denotes for
T26520 42618-42619 CD denotes 5
T26521 42620-42623 NN denotes min
T26522 42624-42626 IN denotes at
T26523 42627-42629 CD denotes 95
T26524 42629-42631 NN denotes °C
T26525 42631-42633 , denotes ,
T26526 42633-42637 RB denotes then
T26527 42638-42644 VBN denotes cycled
T26528 42645-42648 IN denotes for
T26529 42649-42651 CD denotes 45
T26530 42652-42653 NN denotes s
T26531 42654-42656 IN denotes at
T26532 42657-42659 CD denotes 95
T26533 42659-42661 NN denotes °C
T26534 42661-42663 , denotes ,
T26535 42663-42665 CD denotes 45
T26536 42666-42667 NN denotes s
T26537 42668-42670 IN denotes at
T26538 42671-42673 CD denotes 55
T26539 42673-42675 NN denotes °C
T26540 42675-42677 , denotes ,
T26541 42677-42678 CD denotes 1
T26542 42679-42682 NN denotes min
T26543 42683-42685 IN denotes at
T26544 42686-42688 CD denotes 72
T26545 42688-42690 NN denotes °C
T26546 42691-42694 IN denotes for
T26547 42695-42697 CD denotes 35
T26548 42698-42704 NNS denotes cycles
T26549 42705-42709 IN denotes with
T26550 42710-42711 DT denotes a
T26552 42712-42717 JJ denotes final
T26553 42718-42720 CD denotes 72
T26554 42720-42722 NN denotes °C
T26551 42723-42732 NN denotes extension
T26555 42733-42736 IN denotes for
T26556 42737-42739 CD denotes 10
T26557 42740-42743 NN denotes min
T26558 42744-42746 IN denotes on
T26559 42747-42748 DT denotes a
T26561 42749-42751 NNP denotes MJ
T26562 42752-42760 NNP denotes Research
T26560 42761-42764 NNP denotes PTC
T26563 42764-42765 HYPH denotes -
T26564 42765-42768 CD denotes 200
T26565 42768-42769 . denotes .
T26566 42769-42847 sentence denotes The products were visualized on 1.5% agarose gels containing 0.06 μg/ml EtBr.
T26567 42770-42773 DT denotes The
T26568 42774-42782 NNS denotes products
T26570 42783-42787 VBD denotes were
T26569 42788-42798 VBN denotes visualized
T26571 42799-42801 IN denotes on
T26572 42802-42805 CD denotes 1.5
T26573 42805-42806 NN denotes %
T26574 42807-42814 NN denotes agarose
T26575 42815-42819 NNS denotes gels
T26576 42820-42830 VBG denotes containing
T26577 42831-42835 CD denotes 0.06
T26578 42836-42838 NN denotes μg
T26580 42838-42839 SYM denotes /
T26581 42839-42841 NN denotes ml
T26579 42842-42846 NN denotes EtBr
T26582 42846-42847 . denotes .
T26583 42847-42958 sentence denotes Bands of the correct size were excised and incubated in 100 μl of sterile H2O at 80°C for 10 min to elute DNA.
T26584 42848-42853 NNS denotes Bands
T26586 42854-42856 IN denotes of
T26587 42857-42860 DT denotes the
T26589 42861-42868 JJ denotes correct
T26588 42869-42873 NN denotes size
T26590 42874-42878 VBD denotes were
T26585 42879-42886 VBN denotes excised
T26591 42887-42890 CC denotes and
T26592 42891-42900 VBN denotes incubated
T26593 42901-42903 IN denotes in
T26594 42904-42907 CD denotes 100
T26595 42908-42910 NN denotes μl
T26596 42911-42913 IN denotes of
T26597 42914-42921 JJ denotes sterile
T26598 42922-42925 NN denotes H2O
T26599 42926-42928 IN denotes at
T26600 42929-42931 CD denotes 80
T26601 42931-42933 NN denotes °C
T26602 42934-42937 IN denotes for
T26603 42938-42940 CD denotes 10
T26604 42941-42944 NN denotes min
T26605 42945-42947 TO denotes to
T26606 42948-42953 VB denotes elute
T26607 42954-42957 NN denotes DNA
T26608 42957-42958 . denotes .
T26609 42958-43133 sentence denotes Reamplification reactions consisted of 1X PCR buffer, 1.5 mM MgCl2, 0.17 mM dNTPs, 1 μM each primer, 0.1 unit of Taq (Promega) and 10 μl of eluate in a total volume of 50 μl.
T26610 42959-42974 NN denotes Reamplification
T26611 42975-42984 NNS denotes reactions
T26612 42985-42994 VBD denotes consisted
T26613 42995-42997 IN denotes of
T26614 42998-43000 NN denotes 1X
T26616 43001-43004 NN denotes PCR
T26615 43005-43011 NN denotes buffer
T26617 43011-43013 , denotes ,
T26618 43013-43016 CD denotes 1.5
T26619 43017-43019 NN denotes mM
T26620 43020-43025 NN denotes MgCl2
T26621 43025-43027 , denotes ,
T26622 43027-43031 CD denotes 0.17
T26623 43032-43034 NN denotes mM
T26624 43035-43040 NNS denotes dNTPs
T26625 43040-43042 , denotes ,
T26626 43042-43043 CD denotes 1
T26627 43044-43046 NN denotes μM
T26629 43047-43051 DT denotes each
T26628 43052-43058 NN denotes primer
T26630 43058-43060 , denotes ,
T26631 43060-43063 CD denotes 0.1
T26632 43064-43068 NN denotes unit
T26633 43069-43071 IN denotes of
T26634 43072-43075 NN denotes Taq
T26635 43076-43077 -LRB- denotes (
T26636 43077-43084 NNP denotes Promega
T26637 43084-43085 -RRB- denotes )
T26638 43086-43089 CC denotes and
T26639 43090-43092 CD denotes 10
T26640 43093-43095 NN denotes μl
T26641 43096-43098 IN denotes of
T26642 43099-43105 NN denotes eluate
T26643 43106-43108 IN denotes in
T26644 43109-43110 DT denotes a
T26646 43111-43116 JJ denotes total
T26645 43117-43123 NN denotes volume
T26647 43124-43126 IN denotes of
T26648 43127-43129 CD denotes 50
T26649 43130-43132 NN denotes μl
T26650 43132-43133 . denotes .
T26651 43133-43202 sentence denotes The same cycling parameters were used for reamplification reactions.
T26652 43134-43137 DT denotes The
T26654 43138-43142 JJ denotes same
T26655 43143-43150 NN denotes cycling
T26653 43151-43161 NNS denotes parameters
T26657 43162-43166 VBD denotes were
T26656 43167-43171 VBN denotes used
T26658 43172-43175 IN denotes for
T26659 43176-43191 NN denotes reamplification
T26660 43192-43201 NNS denotes reactions
T26661 43201-43202 . denotes .
T26662 43202-43345 sentence denotes Products were visualized on 1% 0.5X TBE agarose gels containing 0.06 μg/ml EtBr, excised and purfied using PCR purification columns (Promega).
T26663 43203-43211 NNS denotes Products
T26665 43212-43216 VBD denotes were
T26664 43217-43227 VBN denotes visualized
T26666 43228-43230 IN denotes on
T26667 43231-43232 CD denotes 1
T26668 43232-43233 NN denotes %
T26670 43234-43238 NN denotes 0.5X
T26671 43239-43242 NN denotes TBE
T26672 43243-43250 NN denotes agarose
T26669 43251-43255 NNS denotes gels
T26673 43256-43266 VBG denotes containing
T26674 43267-43271 CD denotes 0.06
T26675 43272-43274 NN denotes μg
T26677 43274-43275 SYM denotes /
T26678 43275-43277 NN denotes ml
T26676 43278-43282 NN denotes EtBr
T26679 43282-43284 , denotes ,
T26680 43284-43291 VBN denotes excised
T26681 43292-43295 CC denotes and
T26682 43296-43303 VBN denotes purfied
T26683 43304-43309 VBG denotes using
T26684 43310-43313 NN denotes PCR
T26685 43314-43326 NN denotes purification
T26686 43327-43334 NNS denotes columns
T26687 43335-43336 -LRB- denotes (
T26688 43336-43343 NNP denotes Promega
T26689 43343-43344 -RRB- denotes )
T26690 43344-43345 . denotes .
T26691 43345-43502 sentence denotes To quantity each fragment 1 μl of each purified product was run on a 1.0% agarose gel containing 0.06 μg/ml EtBr, along with a DNA mass ladder (Invitrogen).
T26692 43346-43348 TO denotes To
T26693 43349-43357 VB denotes quantity
T26695 43358-43362 DT denotes each
T26696 43363-43371 NN denotes fragment
T26697 43372-43373 CD denotes 1
T26698 43374-43376 NN denotes μl
T26699 43377-43379 IN denotes of
T26700 43380-43384 DT denotes each
T26702 43385-43393 VBN denotes purified
T26701 43394-43401 NN denotes product
T26703 43402-43405 VBD denotes was
T26694 43406-43409 VBN denotes run
T26704 43410-43412 IN denotes on
T26705 43413-43414 DT denotes a
T26707 43415-43418 CD denotes 1.0
T26708 43418-43419 NN denotes %
T26709 43420-43427 NN denotes agarose
T26706 43428-43431 NN denotes gel
T26710 43432-43442 VBG denotes containing
T26711 43443-43447 CD denotes 0.06
T26712 43448-43450 NN denotes μg
T26714 43450-43451 SYM denotes /
T26715 43451-43453 NN denotes ml
T26713 43454-43458 NN denotes EtBr
T26716 43458-43460 , denotes ,
T26717 43460-43465 IN denotes along
T26718 43466-43470 IN denotes with
T26719 43471-43472 DT denotes a
T26721 43473-43476 NN denotes DNA
T26722 43477-43481 NN denotes mass
T26720 43482-43488 NN denotes ladder
T26723 43489-43490 -LRB- denotes (
T26724 43490-43500 NNP denotes Invitrogen
T26725 43500-43501 -RRB- denotes )
T26726 43501-43502 . denotes .
T26727 43502-43592 sentence denotes In a 96 well plate, 15 ng of each PCR product was added to 5 pM of primer for sequencing.
T26728 43503-43505 IN denotes In
T26730 43506-43507 DT denotes a
T26732 43508-43510 CD denotes 96
T26733 43511-43515 NN denotes well
T26731 43516-43521 NN denotes plate
T26734 43521-43523 , denotes ,
T26735 43523-43525 CD denotes 15
T26736 43526-43528 NN denotes ng
T26737 43529-43531 IN denotes of
T26738 43532-43536 DT denotes each
T26740 43537-43540 NN denotes PCR
T26739 43541-43548 NN denotes product
T26741 43549-43552 VBD denotes was
T26729 43553-43558 VBN denotes added
T26742 43559-43561 IN denotes to
T26743 43562-43563 CD denotes 5
T26744 43564-43566 NN denotes pM
T26745 43567-43569 IN denotes of
T26746 43570-43576 NN denotes primer
T26747 43577-43580 IN denotes for
T26748 43581-43591 NN denotes sequencing
T26749 43591-43592 . denotes .
T26750 43592-43764 sentence denotes The College of Agriculture and Environmental Sciences (CAES) Genomics Facility at the University of California, Davis, performed bidirectional sequencing of each amplicon.
T26751 43593-43596 DT denotes The
T26752 43597-43604 NNP denotes College
T26754 43605-43607 IN denotes of
T26755 43608-43619 NNP denotes Agriculture
T26757 43620-43623 CC denotes and
T26758 43624-43637 NNP denotes Environmental
T26756 43638-43646 NNPS denotes Sciences
T26759 43647-43648 -LRB- denotes (
T26760 43648-43652 NNP denotes CAES
T26761 43652-43653 -RRB- denotes )
T26762 43654-43662 NNP denotes Genomics
T26753 43663-43671 NN denotes Facility
T26764 43672-43674 IN denotes at
T26765 43675-43678 DT denotes the
T26766 43679-43689 NNP denotes University
T26767 43690-43692 IN denotes of
T26768 43693-43703 NNP denotes California
T26769 43703-43705 , denotes ,
T26770 43705-43710 NNP denotes Davis
T26771 43710-43712 , denotes ,
T26763 43712-43721 VBD denotes performed
T26772 43722-43735 JJ denotes bidirectional
T26773 43736-43746 NN denotes sequencing
T26774 43747-43749 IN denotes of
T26775 43750-43754 DT denotes each
T26776 43755-43763 NN denotes amplicon
T26777 43763-43764 . denotes .
T26935 43766-43774 NN denotes Sequence
T26936 43775-43783 NN denotes analysis
T26937 43783-43898 sentence denotes B6 mRNA sequences for each gene were downloaded from the May 2004 (mm5) UCSC (NCBI Build 33) genome assembly [28].
T26938 43784-43786 NN denotes B6
T26940 43787-43791 NN denotes mRNA
T26939 43792-43801 NNS denotes sequences
T26942 43802-43805 IN denotes for
T26943 43806-43810 DT denotes each
T26944 43811-43815 NN denotes gene
T26945 43816-43820 VBD denotes were
T26941 43821-43831 VBN denotes downloaded
T26946 43832-43836 IN denotes from
T26947 43837-43840 DT denotes the
T26949 43841-43844 NNP denotes May
T26950 43845-43849 CD denotes 2004
T26951 43850-43851 -LRB- denotes (
T26952 43851-43854 NN denotes mm5
T26953 43854-43855 -RRB- denotes )
T26954 43856-43860 NNP denotes UCSC
T26955 43861-43862 -LRB- denotes (
T26957 43862-43866 NNP denotes NCBI
T26956 43867-43872 NNP denotes Build
T26958 43873-43875 CD denotes 33
T26959 43875-43876 -RRB- denotes )
T26960 43877-43883 NN denotes genome
T26948 43884-43892 NN denotes assembly
T26961 43893-43894 -LRB- denotes [
T26962 43894-43896 CD denotes 28
T26963 43896-43897 -RRB- denotes ]
T26964 43897-43898 . denotes .
T26965 43898-44050 sentence denotes These sequences were imported along with all CAST sequence traces into the SeqMan sequence assembly program (DNASTAR) and manually curated for quality.
T26966 43899-43904 DT denotes These
T26967 43905-43914 NNS denotes sequences
T26969 43915-43919 VBD denotes were
T26968 43920-43928 VBN denotes imported
T26970 43929-43934 IN denotes along
T26971 43935-43939 IN denotes with
T26972 43940-43943 DT denotes all
T26974 43944-43948 NN denotes CAST
T26975 43949-43957 NN denotes sequence
T26973 43958-43964 NNS denotes traces
T26976 43965-43969 IN denotes into
T26977 43970-43973 DT denotes the
T26979 43974-43980 NNP denotes SeqMan
T26980 43981-43989 NN denotes sequence
T26981 43990-43998 NN denotes assembly
T26978 43999-44006 NN denotes program
T26982 44007-44008 -LRB- denotes (
T26983 44008-44015 NNP denotes DNASTAR
T26984 44015-44016 -RRB- denotes )
T26985 44017-44020 CC denotes and
T26986 44021-44029 RB denotes manually
T26987 44030-44037 VBN denotes curated
T26988 44038-44041 IN denotes for
T26989 44042-44049 NN denotes quality
T26990 44049-44050 . denotes .
T26991 44050-44087 sentence denotes Poor quality reads were resequenced.
T26992 44051-44055 JJ denotes Poor
T26993 44056-44063 NN denotes quality
T26994 44064-44069 NNS denotes reads
T26996 44070-44074 VBD denotes were
T26995 44075-44086 VBN denotes resequenced
T26997 44086-44087 . denotes .
T26998 44087-44199 sentence denotes Individual contigs were created for each gene and polymorphisms were detected and curated by manual inspection.
T26999 44088-44098 JJ denotes Individual
T27000 44099-44106 NNS denotes contigs
T27002 44107-44111 VBD denotes were
T27001 44112-44119 VBN denotes created
T27003 44120-44123 IN denotes for
T27004 44124-44128 DT denotes each
T27005 44129-44133 NN denotes gene
T27006 44134-44137 CC denotes and
T27007 44138-44151 NNS denotes polymorphisms
T27009 44152-44156 VBD denotes were
T27008 44157-44165 VBN denotes detected
T27010 44166-44169 CC denotes and
T27011 44170-44177 VBN denotes curated
T27012 44178-44180 IN denotes by
T27013 44181-44187 JJ denotes manual
T27014 44188-44198 NN denotes inspection
T27015 44198-44199 . denotes .
R1000 T3473 T3472 prep on,Carfhg1
R1001 T3474 T3473 pobj MMU5,on
R1002 T3547 T3545 pobj strains,of
R1003 T3475 T3472 punct ", ",Carfhg1
R1004 T3476 T3472 conj Wg3,Carfhg1
R1005 T3477 T3476 prep on,Wg3
R1006 T3548 T3547 prep with,strains
R1007 T3478 T3477 pobj MMU8,on
R1008 T3479 T3476 punct ", ",Wg3
R1009 T3480 T3476 conj Feml2,Wg3
R1010 T3481 T3480 prep on,Feml2
R1011 T3482 T3481 pobj MMU9,on
R1012 T3483 T3480 punct ", ",Feml2
R1013 T3549 T3550 amod identical,regions
R1014 T3484 T3480 conj Wg4,Feml2
R1015 T3485 T3484 cc and,Wg4
R1016 T3486 T3484 conj Cara2,Wg4
R1017 T3550 T3548 pobj regions,with
R1018 T3487 T3484 prep on,Wg4
R1019 T3488 T3487 pobj MMU11,on
R1020 T3489 T3484 cc and,Wg4
R1021 T3490 T3484 conj Carp3,Wg4
R1022 T3551 T3550 compound donor,regions
R1023 T3491 T3490 cc and,Carp3
R1024 T3492 T3490 conj Cara3,Carp3
R1025 T3552 T3543 prep on,panel
R1026 T3493 T3490 prep on,Carp3
R1027 T3494 T3493 pobj MMU17,on
R1028 T3495 T3490 punct ),Carp3
R1029 T3553 T3554 preconj both,B6
R1030 T3554 T3555 nmod B6,backgrounds
R1031 T3496 T3497 poss whose,expression
R1032 T3555 T3552 pobj backgrounds,on
R1033 T3497 T3498 dep expression,was
R1034 T3498 T3490 relcl was,Carp3
R1035 T3499 T3498 acomp independent,was
R1036 T3556 T3554 cc and,B6
R1037 T3500 T3499 prep of,independent
R1038 T3501 T3502 det the,locus
R1039 T3502 T3500 pobj locus,of
R1040 T3557 T3554 conj HG,B6
R1041 T3503 T3502 compound hg,locus
R1042 T3504 T3421 punct .,identified
R1043 T3558 T3541 auxpass were,developed
R1044 T3506 T3507 prep In,developed
R1045 T3559 T3541 prep for,developed
R1046 T3508 T3509 det the,study
R1047 T3509 T3506 pobj study,In
R1048 T3510 T3509 amod current,study
R1049 T3511 T3507 nsubj we,developed
R1050 T3560 T3559 pobj MMU2,for
R1051 T3512 T3507 aux have,developed
R1052 T3513 T3514 npadvmod speed,congenic
R1053 T3514 T3515 amod congenic,strains
R1054 T3561 T3526 punct .,created
R1055 T3515 T3507 dobj strains,developed
R1056 T3516 T3517 aux to,isolate
R1057 T3517 T3507 advcl isolate,developed
R1058 T3563 T3564 det The,panel
R1059 T3518 T3519 predet all,QTL
R1060 T3519 T3517 dobj QTL,isolate
R1061 T3520 T3519 det the,QTL
R1062 T3521 T3519 amod aforementioned,QTL
R1063 T3522 T3507 punct .,developed
R1064 T3524 T3525 amod Single,strains
R1065 T3564 T3566 nsubjpass panel,developed
R1066 T3525 T3526 nsubjpass strains,created
R1067 T3527 T3525 prep on,strains
R1068 T3565 T3564 compound MMU2,panel
R1069 T3528 T3529 det an,background
R1070 T3529 T3527 pobj background,on
R1071 T3530 T3529 compound HG,background
R1072 T3567 T3566 auxpass was,developed
R1073 T3531 T3526 auxpass were,created
R1074 T3532 T3526 prep for,created
R1075 T3568 T3569 aux to,confirm
R1076 T3533 T3534 det each,region
R1077 T3569 T3566 advcl confirm,developed
R1078 T3534 T3532 pobj region,for
R1079 T3535 T3534 amod chromosomal,region
R1080 T3536 T3534 prep outside,region
R1081 T3570 T3571 det the,presence
R1082 T3571 T3569 dobj presence,confirm
R1083 T3572 T3571 prep of,presence
R1084 T3573 T3574 amod multiple,QTL
R1085 T3574 T3572 pobj QTL,of
R1086 T3575 T3569 cc and,confirm
R1087 T3576 T3569 conj test,confirm
R1088 T3577 T3576 prep for,test
R1089 T3578 T3579 compound QTL,hg
R1090 T3579 T3581 compound hg,interactions
R1091 T3580 T3579 punct -,hg
R1092 T3581 T3577 pobj interactions,for
R1093 T3582 T3566 punct .,developed
R1094 T3584 T3585 advmod Additionally,sequenced
R1095 T3586 T3585 punct ", ",sequenced
R1096 T3587 T3585 prep based,sequenced
R1097 T3588 T3587 prep on,based
R1098 T3589 T3590 det the,knowledge
R1099 T3590 T3588 pobj knowledge,on
R1100 T3591 T3590 prep of,knowledge
R1101 T3592 T3593 amod potential,interactions
R1102 T3593 T3591 pobj interactions,of
R1103 T3594 T3595 compound QTL,hg
R1104 T3595 T3593 compound hg,interactions
R1105 T3596 T3595 punct -,hg
R1106 T3597 T3585 punct ", ",sequenced
R1107 T3598 T3585 nsubjpass genes,sequenced
R1108 T3599 T3598 acl involved,genes
R1109 T3600 T3599 prep in,involved
R1110 T3601 T3602 compound Gh,signaling
R1111 T3602 T3600 pobj signaling,in
R1112 T3603 T3598 punct ", ",genes
R1113 T3604 T3605 poss whose,location
R1114 T3605 T3607 dep location,overlapped
R1115 T3606 T3605 amod genomic,location
R1116 T3607 T3598 relcl overlapped,genes
R1117 T3608 T3609 compound hg,QTL
R1118 T3609 T3607 dobj QTL,overlapped
R1119 T3610 T3609 compound modifier,QTL
R1120 T3611 T3609 prep on,QTL
R1121 T3612 T3613 nmod MMU,2
R1122 T3613 T3611 pobj 2,on
R1123 T3614 T3613 punct ", ",2
R1124 T3615 T3613 conj 9,2
R1125 T3616 T3615 punct ", ",9
R1126 T3617 T3615 conj 11,9
R1127 T3618 T3617 cc and,11
R1128 T3619 T3617 conj 17,11
R1129 T3620 T3585 punct ", ",sequenced
R1130 T3621 T3585 auxpass were,sequenced
R1131 T3622 T3585 punct .,sequenced
R1132 T4080 T4081 npadvmod Speed,congenic
R1133 T4081 T4082 amod congenic,strain
R1134 T4082 T4083 compound strain,development
R1135 T4085 T4086 nummod Two,panels
R1136 T4086 T4089 nsubjpass panels,created
R1137 T4087 T4088 npadvmod speed,congenic
R1138 T4088 T4086 amod congenic,panels
R1139 T4090 T4089 auxpass were,created
R1140 T4091 T4089 punct ", ",created
R1141 T4092 T4093 det the,first
R1142 T4093 T4094 nsubj first,dissected
R1143 T4094 T4089 advcl dissected,created
R1144 T4095 T4094 advmod comprehensively,dissected
R1145 T4096 T4094 dobj MMU2,dissected
R1146 T4097 T4098 mark while,isolated
R1147 T4098 T4094 advcl isolated,dissected
R1148 T4099 T4100 det the,second
R1149 T4100 T4098 nsubj second,isolated
R1150 T4101 T4098 dobj QTL,isolated
R1151 T4102 T4098 prep on,isolated
R1152 T4103 T4104 nmod MMU,1
R1153 T4104 T4102 pobj 1,on
R1154 T4105 T4104 punct ", ",1
R1155 T4106 T4104 conj 5,1
R1156 T4107 T4106 punct ", ",5
R1157 T4108 T4106 conj 8,5
R1158 T4109 T4108 punct ", ",8
R1159 T4110 T4108 conj 9,8
R1160 T4111 T4110 punct ", ",9
R1161 T4112 T4110 conj 11,9
R1162 T4113 T4112 cc and,11
R1163 T4114 T4112 conj 17,11
R1164 T4115 T4116 punct (,Table
R1165 T4116 T4098 parataxis Table,isolated
R1166 T4117 T4116 nummod 1,Table
R1167 T4118 T4116 punct ),Table
R1168 T4119 T4089 punct .,created
R1169 T4121 T4122 det The,panel
R1170 T4122 T4124 nsubj panel,consisted
R1171 T4123 T4122 compound MMU2,panel
R1172 T4125 T4124 prep of,consisted
R1173 T4126 T4127 nummod eight,strains
R1174 T4127 T4125 pobj strains,of
R1175 T4128 T4127 amod congenic,strains
R1176 T4129 T4127 acl developed,strains
R1177 T4130 T4129 prep by,developed
R1178 T4131 T4130 pcomp introgressing,by
R1179 T4132 T4133 nummod four,regions
R1180 T4133 T4131 dobj regions,introgressing
R1181 T4134 T4133 amod overlapping,regions
R1182 T4135 T4133 compound donor,regions
R1183 T4136 T4131 prep onto,introgressing
R1184 T4137 T4138 preconj both,B6
R1185 T4138 T4139 nmod B6,backgrounds
R1186 T4139 T4136 pobj backgrounds,onto
R1187 T4140 T4138 cc and,B6
R1188 T4141 T4138 conj HG,B6
R1189 T4142 T4139 amod genetic,backgrounds
R1190 T4143 T4144 punct (,Table
R1191 T4144 T4129 parataxis Table,developed
R1192 T4145 T4144 nummod 1,Table
R1193 T4146 T4144 punct ),Table
R1194 T4147 T4124 punct .,consisted
R1195 T4149 T4150 amod Single,regions
R1196 T4150 T4152 nsubjpass regions,created
R1197 T4151 T4150 compound donor,regions
R1198 T4153 T4150 acl bred,regions
R1199 T4154 T4153 prep onto,bred
R1200 T4155 T4156 det an,background
R1201 T4156 T4154 pobj background,onto
R1202 T4157 T4156 compound HG,background
R1203 T4158 T4152 auxpass were,created
R1204 T4159 T4160 aux to,isolate
R1205 T4160 T4152 advcl isolate,created
R1206 T4161 T4162 det the,QTL
R1207 T4162 T4160 dobj QTL,isolate
R1208 T4163 T4162 amod remaining,QTL
R1209 T4164 T4162 prep on,QTL
R1210 T4165 T4166 nmod MMU,1
R1211 T4166 T4164 pobj 1,on
R1212 T4167 T4166 punct ", ",1
R1213 T4168 T4166 conj 5,1
R1214 T4169 T4168 punct ", ",5
R1215 T4170 T4168 conj 8,5
R1216 T4171 T4170 punct ", ",8
R1217 T4172 T4170 conj 9,8
R1218 T4173 T4172 punct ", ",9
R1219 T4174 T4172 conj 11,9
R1220 T4175 T4174 cc and,11
R1221 T4176 T4174 conj 17,11
R1222 T4177 T4152 punct .,created
R1223 T4179 T4180 nsubj Implementation,accelerated
R1224 T4181 T4179 prep of,Implementation
R1225 T4182 T4183 det a,approach
R1226 T4183 T4181 pobj approach,of
R1227 T4184 T4185 npadvmod speed,congenic
R1228 T4185 T4183 amod congenic,approach
R1229 T4186 T4179 acl using,Implementation
R1230 T4187 T4188 npadvmod marker,assisted
R1231 T4188 T4190 amod assisted,breeding
R1232 T4189 T4188 punct -,assisted
R1233 T4190 T4186 dobj breeding,using
R1234 T4191 T4186 prep with,using
R1235 T4192 T4193 nummod 79,markers
R1236 T4193 T4191 pobj markers,with
R1237 T4194 T4195 npadvmod genome,wide
R1238 T4195 T4193 amod wide,markers
R1239 T4196 T4195 punct -,wide
R1240 T4197 T4193 compound microsatellite,markers
R1241 T4198 T4180 dobj production,accelerated
R1242 T4199 T4198 prep of,production
R1243 T4200 T4201 det all,strains
R1244 T4201 T4199 pobj strains,of
R1245 T4202 T4203 punct [,6
R1246 T4203 T4180 parataxis 6,accelerated
R1247 T4204 T4203 nummod 5,6
R1248 T4205 T4203 punct ",",6
R1249 T4206 T4203 punct ],6
R1250 T4207 T4208 punct (,File
R1251 T4208 T4180 parataxis File,accelerated
R1252 T4209 T4208 amod Additional,File
R1253 T4210 T4208 nummod 1,File
R1254 T4211 T4208 cc and,File
R1255 T4212 T4208 conj Figure,File
R1256 T4213 T4212 nummod 1,Figure
R1257 T4214 T4208 punct ),File
R1258 T4215 T4180 punct .,accelerated
R1259 T4217 T4218 compound Strain,abbreviations
R1260 T4218 T4219 nsubjpass abbreviations,listed
R1261 T4220 T4218 cc and,abbreviations
R1262 T4221 T4222 amod genomic,region
R1263 T4222 T4218 conj region,abbreviations
R1264 T4223 T4222 acl isolated,region
R1265 T4224 T4223 prep by,isolated
R1266 T4225 T4226 det each,strain
R1267 T4226 T4224 pobj strain,by
R1268 T4227 T4219 auxpass are,listed
R1269 T4228 T4219 prep in,listed
R1270 T4229 T4228 pobj Table,in
R1271 T4230 T4229 nummod 1,Table
R1272 T4231 T4219 punct .,listed
R1273 T4233 T4234 prep In,developed
R1274 T4235 T4233 pobj addition,In
R1275 T4236 T4235 prep to,addition
R1276 T4237 T4238 preconj both,panels
R1277 T4238 T4236 pobj panels,to
R1278 T4239 T4238 amod congenic,panels
R1279 T4240 T4234 punct ", ",developed
R1280 T4241 T4242 nummod two,strains
R1281 T4242 T4234 nsubjpass strains,developed
R1282 T4243 T4242 compound control,strains
R1283 T4244 T4245 amod homozygous,B6
R1284 T4245 T4242 appos B6,strains
R1285 T4246 T4245 punct (,B6
R1286 T4247 T4248 nmod B6.CASTC,B6C
R1287 T4248 T4245 appos B6C,B6
R1288 T4249 T4248 punct ;,B6C
R1289 T4250 T4245 punct ),B6
R1290 T4251 T4245 cc or,B6
R1291 T4252 T4245 conj HG,B6
R1292 T4253 T4252 punct (,HG
R1293 T4254 T4255 nmod HG.CASTC,HGC
R1294 T4255 T4252 appos HGC,HG
R1295 T4256 T4255 punct ;,HGC
R1296 T4257 T4245 punct ),B6
R1297 T4258 T4245 prep for,B6
R1298 T4259 T4260 det all,markers
R1299 T4260 T4258 pobj markers,for
R1300 T4261 T4262 npadvmod genome,wide
R1301 T4262 T4260 amod wide,markers
R1302 T4263 T4262 punct -,wide
R1303 T4264 T4242 acl genotyped,strains
R1304 T4265 T4234 auxpass were,developed
R1305 T4266 T4234 prep from,developed
R1306 T4267 T4268 det the,cross
R1307 T4268 T4266 pobj cross,from
R1308 T4269 T4268 amod same,cross
R1309 T4270 T4234 punct (,developed
R1310 T4271 T4234 xcomp see,developed
R1311 T4272 T4271 dobj Methods,see
R1312 T4273 T4234 punct ),developed
R1313 T4274 T4234 cc and,developed
R1314 T4275 T4234 conj served,developed
R1315 T4276 T4275 prep as,served
R1316 T4277 T4278 det the,basis
R1317 T4278 T4276 pobj basis,as
R1318 T4279 T4278 prep for,basis
R1319 T4280 T4281 compound strain,comparisons
R1320 T4281 T4279 pobj comparisons,for
R1321 T4282 T4234 punct .,developed
R1322 T4284 T4285 prep After,characterized
R1323 T4286 T4284 pcomp stabilizing,After
R1324 T4287 T4288 det each,congenic
R1325 T4288 T4286 dobj congenic,stabilizing
R1326 T4289 T4285 punct ", ",characterized
R1327 T4290 T4291 quantmod 12,14
R1328 T4291 T4285 nsubjpass 14,characterized
R1329 T4292 T4291 quantmod of,14
R1330 T4293 T4285 auxpass were,characterized
R1331 T4294 T4285 advmod phenotypically,characterized
R1332 T4295 T4285 prep for,characterized
R1333 T4296 T4295 pobj growth,for
R1334 T4297 T4296 cc and,growth
R1335 T4298 T4296 conj adiposity,growth
R1336 T4299 T4285 punct .,characterized
R1337 T4301 T4302 det The,strains
R1338 T4302 T4306 nsubjpass strains,characterized
R1339 T4303 T4302 nmod HG2D,strains
R1340 T4304 T4303 cc and,HG2D
R1341 T4305 T4303 conj HG5,HG2D
R1342 T4307 T4306 auxpass were,characterized
R1343 T4308 T4306 neg not,characterized
R1344 T4309 T4306 prep due,characterized
R1345 T4310 T4309 pcomp to,due
R1346 T4311 T4312 amod reproductive,problems
R1347 T4312 T4309 pobj problems,due
R1348 T4313 T4306 punct .,characterized
R1349 T4315 T4316 det The,points
R1350 T4316 T4319 nsubjpass points,refined
R1351 T4317 T4316 amod recombinant,points
R1352 T4318 T4316 compound end,points
R1353 T4320 T4316 prep for,points
R1354 T4321 T4322 det all,strains
R1355 T4322 T4320 pobj strains,for
R1356 T4323 T4319 auxpass were,refined
R1357 T4324 T4319 advcl using,refined
R1358 T4325 T4326 compound microsatellite,markers
R1359 T4326 T4324 dobj markers,using
R1360 T4327 T4326 acl flanking,markers
R1361 T4328 T4329 det each,region
R1362 T4329 T4327 dobj region,flanking
R1363 T4330 T4329 compound donor,region
R1364 T4331 T4332 punct (,File
R1365 T4332 T4319 parataxis File,refined
R1366 T4333 T4332 amod Additional,File
R1367 T4334 T4332 nummod 2,File
R1368 T4335 T4332 punct ),File
R1369 T4336 T4319 punct .,refined
R1378 T6950 T6951 nmod MMU2,strain
R1379 T6951 T6954 compound strain,characterization
R1380 T6952 T6953 npadvmod speed,congenic
R1381 T6953 T6951 amod congenic,strain
R1382 T6956 T6957 prep Due,queried
R1383 T6958 T6956 pcomp to,Due
R1384 T6959 T6960 det the,nature
R1385 T6960 T6956 pobj nature,Due
R1386 T6961 T6960 amod overlapping,nature
R1387 T6962 T6960 prep of,nature
R1388 T6963 T6964 det the,congenics
R1389 T6964 T6962 pobj congenics,of
R1390 T6965 T6964 compound MMU2,congenics
R1391 T6966 T6957 punct ", ",queried
R1392 T6967 T6968 nummod five,regions
R1393 T6968 T6957 nsubjpass regions,queried
R1394 T6969 T6968 amod distinct,regions
R1395 T6970 T6968 amod chromosomal,regions
R1396 T6971 T6968 punct (,regions
R1397 T6972 T6973 nmod Regions,I
R1398 T6973 T6968 appos I,regions
R1399 T6974 T6975 punct –,V
R1400 T7033 T7013 punct .,describe
R1401 T6975 T6973 prep V,I
R1402 T7035 T7036 nmod B6.CAST,MMU2
R1403 T6976 T6957 punct ),queried
R1404 T7036 T7037 nmod MMU2,strains
R1405 T6977 T6957 auxpass were,queried
R1406 T7038 T7039 npadvmod speed,congenic
R1407 T7039 T7037 amod congenic,strains
R1408 T6978 T6957 prep for,queried
R1409 T7041 T7042 det The,strain
R1410 T7042 T7044 nsubj strain,exhibited
R1411 T6979 T6980 det the,presence
R1412 T7043 T7042 compound B62D,strain
R1413 T7045 T7046 det the,decreases
R1414 T6980 T6978 pobj presence,for
R1415 T7046 T7044 dobj decreases,exhibited
R1416 T7047 T7046 amod largest,decreases
R1417 T6981 T6980 prep of,presence
R1418 T7048 T7049 punct (,0.0001
R1419 T7049 T7047 parataxis 0.0001,largest
R1420 T7050 T7049 nsubj P,0.0001
R1421 T7051 T7049 punct <,0.0001
R1422 T7052 T7049 punct ),0.0001
R1423 T7053 T7046 prep in,decreases
R1424 T7054 T7055 compound body,weight
R1425 T7055 T7053 pobj weight,in
R1426 T7056 T7046 prep of,decreases
R1427 T7057 T7058 det any,B6.CAST
R1428 T7058 T7056 pobj B6.CAST,of
R1429 T6982 T6981 pobj QTL,of
R1430 T7059 T7058 amod congenic,B6.CAST
R1431 T7060 T7061 punct (,File
R1432 T7061 T7044 parataxis File,exhibited
R1433 T7062 T7061 amod Additional,File
R1434 T6983 T6984 punct (,Figure
R1435 T7063 T7061 nummod 3,File
R1436 T7064 T7061 punct ),File
R1437 T6984 T6957 parataxis Figure,queried
R1438 T7065 T7044 punct .,exhibited
R1439 T7067 T7068 det Both,sexes
R1440 T6985 T6984 nummod 2,Figure
R1441 T6986 T6984 punct ),Figure
R1442 T7068 T7069 nsubj sexes,had
R1443 T7070 T7069 dobj reductions,had
R1444 T7071 T7070 prep in,reductions
R1445 T6987 T6957 punct .,queried
R1446 T7072 T7071 pobj weight,in
R1447 T7073 T7070 prep at,reductions
R1448 T7074 T7075 nummod 2,weeks
R1449 T6989 T6990 prep As,tested
R1450 T7075 T7073 pobj weeks,at
R1451 T7076 T7074 punct (,2
R1452 T7077 T7074 appos 2WK,2
R1453 T7078 T7074 punct ),2
R1454 T6991 T6992 det a,analysis
R1455 T7079 T7074 punct ", ",2
R1456 T7080 T7074 conj 3,2
R1457 T7081 T7080 punct (,3
R1458 T6992 T6989 pobj analysis,As
R1459 T7082 T7080 appos 3WK,3
R1460 T7083 T7080 punct ),3
R1461 T7084 T7080 punct ", ",3
R1462 T6993 T6992 amod separate,analysis
R1463 T7085 T7080 conj 6,3
R1464 T7086 T7085 punct (,6
R1465 T6994 T6990 nsubj we,tested
R1466 T7087 T7085 appos 6WK,6
R1467 T7088 T7085 punct ),6
R1468 T7089 T7085 cc and,6
R1469 T7090 T7085 conj 9,6
R1470 T6995 T6990 advmod also,tested
R1471 T7091 T7090 punct (,9
R1472 T7092 T7090 appos 9WK,9
R1473 T7093 T7075 punct ),weeks
R1474 T7094 T7075 prep of,weeks
R1475 T7095 T7094 pobj age,of
R1476 T7096 T7069 prep compared,had
R1477 T6996 T6990 prep for,tested
R1478 T7097 T7096 prep to,compared
R1479 T6997 T6996 pobj interactions,for
R1480 T6998 T6997 prep between,interactions
R1481 T7098 T7099 compound control,mice
R1482 T7099 T7097 pobj mice,to
R1483 T6999 T7000 det each,region
R1484 T7100 T7099 compound B6C,mice
R1485 T7101 T7102 punct (,Figure
R1486 T7000 T6998 pobj region,between
R1487 T7102 T7069 parataxis Figure,had
R1488 T7103 T7102 nummod 3,Figure
R1489 T7104 T7102 punct ),Figure
R1490 T7001 T7000 compound donor,region
R1491 T7105 T7069 punct .,had
R1492 T7107 T7108 prep Despite,observed
R1493 T7002 T7000 cc and,region
R1494 T7109 T7110 amod large,decreases
R1495 T7003 T7004 det the,backgrounds
R1496 T7110 T7107 pobj decreases,Despite
R1497 T7004 T7000 conj backgrounds,region
R1498 T7111 T7110 prep in,decreases
R1499 T7112 T7113 compound body,weight
R1500 T7113 T7111 pobj weight,in
R1501 T7005 T7004 nummod two,backgrounds
R1502 T7114 T7108 punct ", ",observed
R1503 T7115 T7116 det no,differences
R1504 T7116 T7108 nsubjpass differences,observed
R1505 T7117 T7116 prep in,differences
R1506 T7006 T7004 amod distinct,backgrounds
R1507 T7118 T7119 compound growth,rates
R1508 T7119 T7117 pobj rates,in
R1509 T7120 T7121 punct (,gain
R1510 T7007 T7004 amod genetic,backgrounds
R1511 T7121 T7116 parataxis gain,differences
R1512 T7122 T7121 dep G26,gain
R1513 T7123 T7121 punct ", ",gain
R1514 T7008 T6990 punct .,tested
R1515 T7124 T7121 compound weight,gain
R1516 T7125 T7121 prep from,gain
R1517 T7126 T7127 quantmod 2,6
R1518 T7010 T7011 det The,sections
R1519 T7127 T7129 nummod 6,weeks
R1520 T7128 T7127 quantmod to,6
R1521 T7129 T7125 pobj weeks,from
R1522 T7130 T7121 cc and,gain
R1523 T7011 T7013 nsubj sections,describe
R1524 T7131 T7132 dep G29,gain
R1525 T7132 T7121 conj gain,gain
R1526 T7133 T7132 punct ", ",gain
R1527 T7134 T7132 compound weight,gain
R1528 T7135 T7132 prep from,gain
R1529 T7136 T7137 quantmod 2,9
R1530 T7012 T7011 amod following,sections
R1531 T7137 T7139 nummod 9,weeks
R1532 T7014 T7015 det the,phenotypes
R1533 T7015 T7013 dobj phenotypes,describe
R1534 T7138 T7137 quantmod to,9
R1535 T7016 T7015 prep for,phenotypes
R1536 T7139 T7135 pobj weeks,from
R1537 T7140 T7132 punct ),gain
R1538 T7141 T7108 auxpass were,observed
R1539 T7017 T7018 det each,strain
R1540 T7142 T7143 punct (,File
R1541 T7143 T7108 parataxis File,observed
R1542 T7144 T7143 amod Additional,File
R1543 T7018 T7016 pobj strain,for
R1544 T7145 T7143 nummod 3,File
R1545 T7146 T7143 punct ),File
R1546 T7147 T7108 punct .,observed
R1547 T7019 T7018 nmod B6.CAST,strain
R1548 T7149 T7150 advmod Therefore,harbors
R1549 T7020 T7019 cc and,B6.CAST
R1550 T7021 T7019 conj HG.CAST,B6.CAST
R1551 T7151 T7150 punct ", ",harbors
R1552 T7152 T7153 det the,region
R1553 T7153 T7150 nsubj region,harbors
R1554 T7154 T7153 nmod B62D,region
R1555 T7022 T7023 npadvmod speed,congenic
R1556 T7155 T7153 amod unique,region
R1557 T7156 T7153 punct (,region
R1558 T7157 T7153 appos Region,region
R1559 T7023 T7018 amod congenic,strain
R1560 T7158 T7157 nummod V,Region
R1561 T7159 T7150 punct ),harbors
R1562 T7160 T7161 preconj either,QTL
R1563 T7024 T7025 advmod as,as
R1564 T7161 T7150 dobj QTL,harbors
R1565 T7162 T7161 det an,QTL
R1566 T7163 T7164 amod early,growth
R1567 T7025 T7015 cc as,phenotypes
R1568 T7164 T7161 compound growth,QTL
R1569 T7165 T7164 punct -,growth
R1570 T7026 T7025 advmod well,as
R1571 T7166 T7161 cc or,QTL
R1572 T7167 T7168 amod maternal,effect
R1573 T7168 T7161 conj effect,QTL
R1574 T7027 T7028 det the,results
R1575 T7169 T7168 compound genotype,effect
R1576 T7170 T7171 dep which,produces
R1577 T7171 T7168 relcl produces,effect
R1578 T7172 T7173 det a,decrease
R1579 T7173 T7171 dobj decrease,produces
R1580 T7174 T7173 amod distinct,decrease
R1581 T7028 T7015 conj results,phenotypes
R1582 T7175 T7173 prep in,decrease
R1583 T7176 T7177 compound body,weight
R1584 T7177 T7175 pobj weight,in
R1585 T7178 T7179 amod prior,to
R1586 T7029 T7028 prep of,results
R1587 T7179 T7171 prep to,produces
R1588 T7180 T7179 pobj 2WK,to
R1589 T7030 T7031 det the,analysis
R1590 T7181 T7150 punct .,harbors
R1591 T7031 T7029 pobj analysis,of
R1592 T7183 T7184 det These,effects
R1593 T7032 T7031 compound interaction,analysis
R1594 T7184 T7185 nsubj effects,are
R1595 T7243 T7244 nsubj 9WK,was
R1596 T7186 T7185 acomp evident,are
R1597 T7187 T7185 prep in,are
R1598 T7188 T7189 det the,curves
R1599 T7189 T7187 pobj curves,in
R1600 T7190 T7189 compound growth,curves
R1601 T7244 T7241 ccomp was,were
R1602 T7191 T7189 prep for,curves
R1603 T7192 T7193 det both,sexes
R1604 T7245 T7244 acomp significant,was
R1605 T7193 T7191 pobj sexes,for
R1606 T7194 T7193 prep of,sexes
R1607 T7246 T7241 punct ", ",were
R1608 T7195 T7196 det each,strain
R1609 T7196 T7194 pobj strain,of
R1610 T7247 T7248 amod female,6WK
R1611 T7197 T7198 punct (,Figure
R1612 T7198 T7185 parataxis Figure,are
R1613 T7199 T7198 nummod 3,Figure
R1614 T7248 T7241 nsubj 6WK,were
R1615 T7200 T7198 punct ),Figure
R1616 T7201 T7185 punct .,are
R1617 T7249 T7248 cc and,6WK
R1618 T7203 T7204 advmod Additionally,displayed
R1619 T7250 T7248 conj 9WK,6WK
R1620 T7205 T7204 punct ", ",displayed
R1621 T7206 T7207 compound B62D,mice
R1622 T7207 T7204 nsubj mice,displayed
R1623 T7251 T7241 acomp suggestive,were
R1624 T7208 T7209 advmod significantly,shorter
R1625 T7209 T7210 amod shorter,lengths
R1626 T7210 T7204 dobj lengths,displayed
R1627 T7252 T7241 prep at,were
R1628 T7211 T7210 compound tail,lengths
R1629 T7212 T7204 prep despite,displayed
R1630 T7213 T7214 det no,difference
R1631 T7214 T7212 pobj difference,despite
R1632 T7215 T7214 prep in,difference
R1633 T7216 T7217 amod naso-anal,length
R1634 T7253 T7254 nsubj P,0.05
R1635 T7217 T7215 pobj length,in
R1636 T7218 T7217 punct (,length
R1637 T7219 T7217 appos NA,length
R1638 T7220 T7204 punct ),displayed
R1639 T7254 T7252 pcomp 0.05,at
R1640 T7221 T7222 punct (,Table
R1641 T7222 T7204 parataxis Table,displayed
R1642 T7223 T7222 nummod 2,Table
R1643 T7255 T7254 punct <,0.05
R1644 T7224 T7222 punct ),Table
R1645 T7225 T7204 punct .,displayed
R1646 T7256 T7241 punct ),were
R1647 T7227 T7228 prep In,displayed
R1648 T7257 T7234 cc and,decreases
R1649 T7229 T7227 pobj contrast,In
R1650 T7230 T7228 punct ", ",displayed
R1651 T7231 T7232 compound B62M,mice
R1652 T7232 T7228 nsubj mice,displayed
R1653 T7258 T7259 amod significant,decreases
R1654 T7233 T7234 amod small,decreases
R1655 T7234 T7228 dobj decreases,displayed
R1656 T7259 T7234 conj decreases,decreases
R1657 T7235 T7234 prep in,decreases
R1658 T7236 T7237 compound body,weights
R1659 T7260 T7259 prep in,decreases
R1660 T7237 T7235 pobj weights,in
R1661 T7238 T7237 cc and,weights
R1662 T7239 T7237 conj growth,weights
R1663 T7240 T7241 punct (,were
R1664 T7261 T7262 nmod NA,length
R1665 T7241 T7234 parataxis were,decreases
R1666 T7242 T7243 amod male,9WK
R1667 T7262 T7260 pobj length,in
R1668 T7263 T7264 punct (,0.0152
R1669 T7264 T7261 parataxis 0.0152,NA
R1670 T7349 T7350 compound tail,length
R1671 T7350 T7347 conj length,weight
R1672 T7351 T7350 punct ", ",length
R1673 T7265 T7266 amod male,P
R1674 T7352 T7350 cc but,length
R1675 T7353 T7352 neg not,but
R1676 T7354 T7350 conj NA,length
R1677 T7266 T7264 nsubj P,0.0152
R1678 T7355 T7333 punct .,disjoined
R1679 T7267 T7264 punct =,0.0152
R1680 T7357 T7358 det The,QTL
R1681 T7358 T7360 nsubj QTL,increases
R1682 T7359 T7358 amod third,QTL
R1683 T7268 T7264 punct ),0.0152
R1684 T7361 T7358 punct ", ",QTL
R1685 T7362 T7358 acl located,QTL
R1686 T7269 T7261 cc and,NA
R1687 T7363 T7362 prep within,located
R1688 T7364 T7365 det the,region
R1689 T7270 T7261 conj tail,NA
R1690 T7365 T7363 pobj region,within
R1691 T7366 T7365 nmod B62D,region
R1692 T7367 T7365 amod unique,region
R1693 T7271 T7272 punct (,File
R1694 T7368 T7365 punct (,region
R1695 T7369 T7365 appos Region,region
R1696 T7272 T7228 parataxis File,displayed
R1697 T7370 T7369 nummod V,Region
R1698 T7371 T7360 punct ),increases
R1699 T7372 T7360 punct ", ",increases
R1700 T7373 T7360 dobj NA,increases
R1701 T7273 T7272 amod Additional,File
R1702 T7374 T7360 advcl canceling,increases
R1703 T7375 T7376 det the,effects
R1704 T7274 T7272 nummod 3,File
R1705 T7376 T7374 dobj effects,canceling
R1706 T7377 T7376 prep of,effects
R1707 T7378 T7379 det the,QTL
R1708 T7275 T7272 cc and,File
R1709 T7379 T7381 nsubj QTL,decreasing
R1710 T7380 T7379 compound B62M,QTL
R1711 T7381 T7377 pcomp decreasing,of
R1712 T7276 T7272 conj Table,File
R1713 T7382 T7383 punct (,Region
R1714 T7383 T7379 parataxis Region,QTL
R1715 T7277 T7276 nummod 2,Table
R1716 T7384 T7383 nummod IV,Region
R1717 T7385 T7383 punct ),Region
R1718 T7278 T7272 punct ),File
R1719 T7386 T7381 dobj NA,decreasing
R1720 T7279 T7228 punct .,displayed
R1721 T7387 T7360 punct .,increases
R1722 T7281 T7282 det The,decrease
R1723 T7389 T7390 compound B62PM,females
R1724 T7390 T7391 nsubj females,had
R1725 T7282 T7283 nsubj decrease,is
R1726 T7392 T7391 dobj decreases,had
R1727 T7393 T7392 prep in,decreases
R1728 T7394 T7395 det all,traits
R1729 T7284 T7282 prep in,decrease
R1730 T7395 T7393 pobj traits,in
R1731 T7396 T7397 npadvmod growth,related
R1732 T7397 T7395 amod related,traits
R1733 T7398 T7397 punct -,related
R1734 T7399 T7395 prep except,traits
R1735 T7400 T7399 pobj 2WK,except
R1736 T7401 T7400 cc and,2WK
R1737 T7285 T7284 pobj NA,in
R1738 T7402 T7400 conj 3WK,2WK
R1739 T7403 T7391 punct ", ",had
R1740 T7404 T7405 mark while,seen
R1741 T7405 T7391 advcl seen,had
R1742 T7286 T7282 prep in,decrease
R1743 T7406 T7407 det no,differences
R1744 T7407 T7405 nsubjpass differences,seen
R1745 T7408 T7405 auxpass were,seen
R1746 T7287 T7288 compound B62M,mice
R1747 T7409 T7405 prep in,seen
R1748 T7410 T7409 pobj males,in
R1749 T7288 T7286 pobj mice,in
R1750 T7411 T7412 punct (,File
R1751 T7412 T7391 parataxis File,had
R1752 T7413 T7412 amod Additional,File
R1753 T7289 T7283 acomp surprising,is
R1754 T7414 T7412 nummod 3,File
R1755 T7415 T7412 punct ),File
R1756 T7416 T7391 punct .,had
R1757 T7290 T7291 mark since,nested
R1758 T7418 T7419 advmod Similarly,showed
R1759 T7291 T7283 advcl nested,is
R1760 T7420 T7419 punct ", ",showed
R1761 T7421 T7422 advmod only,females
R1762 T7292 T7293 det the,region
R1763 T7422 T7419 nsubj females,showed
R1764 T7423 T7422 compound B62P,females
R1765 T7424 T7422 cc and,females
R1766 T7293 T7291 nsubjpass region,nested
R1767 T7425 T7424 neg not,and
R1768 T7294 T7293 compound 2M,region
R1769 T7426 T7422 conj males,females
R1770 T7427 T7428 amod significant,decreases
R1771 T7428 T7419 dobj decreases,showed
R1772 T7429 T7428 prep in,decreases
R1773 T7430 T7429 pobj 9WK,in
R1774 T7295 T7293 compound donor,region
R1775 T7431 T7430 punct ", ",9WK
R1776 T7432 T7430 conj G26,9WK
R1777 T7296 T7291 auxpass is,nested
R1778 T7433 T7432 cc and,G26
R1779 T7434 T7432 conj G29,G26
R1780 T7435 T7436 punct (,File
R1781 T7297 T7291 advmod entirely,nested
R1782 T7436 T7419 parataxis File,showed
R1783 T7437 T7436 amod Additional,File
R1784 T7438 T7436 nummod 3,File
R1785 T7439 T7436 punct ),File
R1786 T7440 T7419 punct ", ",showed
R1787 T7441 T7419 advcl indicating,showed
R1788 T7298 T7291 prep within,nested
R1789 T7442 T7443 det these,strains
R1790 T7299 T7300 det the,region
R1791 T7443 T7445 nsubj strains,share
R1792 T7444 T7443 nummod two,strains
R1793 T7300 T7298 pobj region,within
R1794 T7445 T7441 advcl share,indicating
R1795 T7446 T7447 det a,QTL
R1796 T7301 T7300 compound 2D,region
R1797 T7447 T7445 dobj QTL,share
R1798 T7448 T7449 amod female,specific
R1799 T7449 T7447 amod specific,QTL
R1800 T7302 T7300 compound donor,region
R1801 T7450 T7447 compound growth,QTL
R1802 T7451 T7452 punct (,Region
R1803 T7303 T7291 cc and,nested
R1804 T7452 T7445 parataxis Region,share
R1805 T7453 T7452 nummod II,Region
R1806 T7454 T7452 punct ),Region
R1807 T7304 T7305 compound B62D,mice
R1808 T7305 T7306 nsubj mice,showed
R1809 T7306 T7291 conj showed,nested
R1810 T7455 T7419 punct .,showed
R1811 T7307 T7308 det no,difference
R1812 T7457 T7458 prep In,linked
R1813 T7308 T7306 dobj difference,showed
R1814 T7459 T7460 det the,scan
R1815 T7460 T7457 pobj scan,In
R1816 T7309 T7308 prep in,difference
R1817 T7461 T7460 amod original,scan
R1818 T7462 T7460 compound genome,scan
R1819 T7463 T7464 compound body,fat
R1820 T7310 T7309 pobj NA,in
R1821 T7464 T7465 compound fat,percentage
R1822 T7465 T7458 nsubjpass percentage,linked
R1823 T7311 T7312 punct (,Figure
R1824 T7466 T7467 mark as,determined
R1825 T7467 T7465 advcl determined,percentage
R1826 T7312 T7306 parataxis Figure,showed
R1827 T7468 T7467 prep by,determined
R1828 T7469 T7470 amod chemical,analysis
R1829 T7470 T7468 pobj analysis,by
R1830 T7313 T7312 nummod 2,Figure
R1831 T7471 T7470 amod compositional,analysis
R1832 T7472 T7458 auxpass was,linked
R1833 T7473 T7458 neg not,linked
R1834 T7474 T7458 prep to,linked
R1835 T7475 T7474 pobj markers,to
R1836 T7476 T7475 prep on,markers
R1837 T7477 T7476 pobj MMU2,on
R1838 T7314 T7312 punct ),Figure
R1839 T7478 T7479 punct [,24
R1840 T7479 T7458 parataxis 24,linked
R1841 T7480 T7479 punct ],24
R1842 T7481 T7458 punct .,linked
R1843 T7315 T7283 punct .,is
R1844 T7483 T7484 advmod However,chose
R1845 T7317 T7318 det These,data
R1846 T7485 T7484 punct ", ",chose
R1847 T7486 T7487 mark since,found
R1848 T7487 T7484 advcl found,chose
R1849 T7318 T7319 nsubj data,indicate
R1850 T7488 T7489 amod numerous,QTL
R1851 T7489 T7487 nsubjpass QTL,found
R1852 T7490 T7489 compound obesity,QTL
R1853 T7320 T7321 det the,presence
R1854 T7491 T7487 aux have,found
R1855 T7492 T7487 auxpass been,found
R1856 T7493 T7487 prep on,found
R1857 T7494 T7493 pobj MMU2,on
R1858 T7495 T7496 punct [,2
R1859 T7321 T7319 dobj presence,indicate
R1860 T7496 T7487 parataxis 2,found
R1861 T7497 T7496 punct ],2
R1862 T7498 T7487 punct ", ",found
R1863 T7322 T7321 prep of,presence
R1864 T7499 T7500 dep some,discovered
R1865 T7500 T7487 advcl discovered,found
R1866 T7323 T7324 nummod three,QTL
R1867 T7501 T7499 prep of,some
R1868 T7502 T7501 pobj which,of
R1869 T7503 T7500 auxpass were,discovered
R1870 T7324 T7322 pobj QTL,of
R1871 T7504 T7500 prep in,discovered
R1872 T7505 T7504 pobj B6,in
R1873 T7506 T7500 prep by,discovered
R1874 T7325 T7324 prep with,QTL
R1875 T7507 T7508 compound CAST,crosses
R1876 T7508 T7506 pobj crosses,by
R1877 T7326 T7327 det the,region
R1878 T7509 T7510 punct [,25
R1879 T7510 T7500 parataxis 25,discovered
R1880 T7327 T7325 pobj region,with
R1881 T7511 T7510 nummod 9,25
R1882 T7512 T7510 punct ",",25
R1883 T7513 T7510 punct ],25
R1884 T7328 T7327 nmod 2D,region
R1885 T7514 T7484 punct ", ",chose
R1886 T7515 T7484 nsubj we,chose
R1887 T7516 T7517 aux to,measure
R1888 T7517 T7484 xcomp measure,chose
R1889 T7518 T7519 amod dissected,weights
R1890 T7519 T7517 dobj weights,measure
R1891 T7329 T7327 amod unique,region
R1892 T7520 T7521 compound fat,pad
R1893 T7521 T7519 compound pad,weights
R1894 T7522 T7517 prep as,measure
R1895 T7330 T7319 punct .,indicate
R1896 T7523 T7524 det a,measure
R1897 T7524 T7522 pobj measure,as
R1898 T7525 T7526 advmod more,sensitive
R1899 T7332 T7333 dep Two,disjoined
R1900 T7526 T7524 amod sensitive,measure
R1901 T7527 T7524 prep of,measure
R1902 T7334 T7332 prep of,Two
R1903 T7528 T7527 pobj adiposity,of
R1904 T7529 T7484 punct .,chose
R1905 T7335 T7334 pobj which,of
R1906 T7531 T7532 nsubj Table,lists
R1907 T7336 T7333 auxpass are,disjoined
R1908 T7533 T7531 nummod 2,Table
R1909 T7534 T7535 det the,weights
R1910 T7337 T7333 agent by,disjoined
R1911 T7535 T7532 dobj weights,lists
R1912 T7536 T7535 prep of,weights
R1913 T7537 T7538 amod gonadal,pads
R1914 T7338 T7339 det the,strains
R1915 T7538 T7536 pobj pads,of
R1916 T7339 T7337 pobj strains,by
R1917 T7539 T7540 punct (,GFP
R1918 T7540 T7537 parataxis GFP,gonadal
R1919 T7541 T7540 punct ),GFP
R1920 T7340 T7339 nmod B62M,strains
R1921 T7542 T7537 punct ", ",gonadal
R1922 T7543 T7537 conj femoral,gonadal
R1923 T7544 T7545 punct (,FFP
R1924 T7341 T7340 cc and,B62M
R1925 T7545 T7543 parataxis FFP,femoral
R1926 T7546 T7545 punct ),FFP
R1927 T7547 T7543 punct ", ",femoral
R1928 T7548 T7543 conj mesenteric,femoral
R1929 T7342 T7340 conj B62D,B62M
R1930 T7549 T7550 punct (,MFP
R1931 T7343 T7333 cc and,disjoined
R1932 T7550 T7548 parataxis MFP,mesenteric
R1933 T7551 T7550 punct ),MFP
R1934 T7552 T7548 cc and,mesenteric
R1935 T7344 T7345 advmod additively,decrease
R1936 T7553 T7548 conj retroperitoneal,mesenteric
R1937 T7554 T7555 punct (,RFP
R1938 T7555 T7553 parataxis RFP,retroperitoneal
R1939 T7556 T7555 punct ),RFP
R1940 T7557 T7538 compound fat,pads
R1941 T7558 T7532 punct ", ",lists
R1942 T7345 T7333 conj decrease,disjoined
R1943 T7559 T7532 prep along,lists
R1944 T7346 T7347 compound body,weight
R1945 T7347 T7345 dobj weight,decrease
R1946 T7348 T7347 cc and,weight
R1947 T7560 T7559 prep with,along
R1948 T7561 T7562 amod total,weight
R1949 T7562 T7560 pobj weight,with
R1950 T7666 T7665 auxpass is,located
R1951 T7563 T7564 compound fat,pad
R1952 T7564 T7562 compound pad,weight
R1953 T7565 T7562 punct (,weight
R1954 T7566 T7562 appos sum,weight
R1955 T7567 T7566 prep of,sum
R1956 T7667 T7665 prep in,located
R1957 T7568 T7569 det the,pads
R1958 T7569 T7567 pobj pads,of
R1959 T7668 T7669 det the,region
R1960 T7570 T7569 nummod four,pads
R1961 T7571 T7569 compound fat,pads
R1962 T7572 T7562 punct ),weight
R1963 T7573 T7562 punct ", ",weight
R1964 T7669 T7667 pobj region,in
R1965 T7574 T7575 compound adiposity,index
R1966 T7575 T7562 conj index,weight
R1967 T7670 T7669 nmod B62D,region
R1968 T7576 T7577 punct (,WSAC
R1969 T7577 T7575 parataxis WSAC,index
R1970 T7578 T7579 nsubj AI,TF
R1971 T7579 T7577 ccomp TF,WSAC
R1972 T7671 T7669 amod unique,region
R1973 T7580 T7579 punct =,TF
R1974 T7581 T7582 punct /,weight
R1975 T7672 T7669 punct (,region
R1976 T7582 T7579 prep weight,TF
R1977 T7583 T7582 prep at,weight
R1978 T7584 T7583 pobj sacrifice,at
R1979 T7673 T7669 appos Region,region
R1980 T7585 T7577 punct (,WSAC
R1981 T7586 T7577 punct ),WSAC
R1982 T7587 T7577 punct ),WSAC
R1983 T7674 T7673 nummod V,Region
R1984 T7588 T7575 cc and,index
R1985 T7589 T7590 compound body,index
R1986 T7590 T7575 conj index,index
R1987 T7675 T7660 punct ),indicates
R1988 T7591 T7590 compound mass,index
R1989 T7592 T7593 punct (,WSAC
R1990 T7676 T7660 punct .,indicates
R1991 T7593 T7590 parataxis WSAC,index
R1992 T7594 T7593 nsubj BMI,WSAC
R1993 T7595 T7593 punct =,WSAC
R1994 T7596 T7597 punct /,NA2
R1995 T7597 T7593 prep NA2,WSAC
R1996 T7598 T7599 punct *,100
R1997 T7678 T7679 advmod Only,differences
R1998 T7599 T7597 acl 100,NA2
R1999 T7600 T7593 punct ),WSAC
R2000 T7601 T7532 prep for,lists
R2001 T7602 T7603 det each,strain
R2002 T7603 T7601 pobj strain,for
R2003 T7679 T7681 nsubjpass differences,observed
R2004 T7604 T7605 npadvmod MMU2,congenic
R2005 T7605 T7603 amod congenic,strain
R2006 T7606 T7532 punct .,lists
R2007 T7680 T7679 amod minor,differences
R2008 T7608 T7609 advcl Similar,displayed
R2009 T7682 T7679 prep in,differences
R2010 T7610 T7608 prep to,Similar
R2011 T7611 T7612 amod large,differences
R2012 T7612 T7610 pobj differences,to
R2013 T7683 T7684 amod various,weights
R2014 T7613 T7612 prep in,differences
R2015 T7684 T7682 pobj weights,in
R2016 T7614 T7615 compound body,weight
R2017 T7615 T7613 pobj weight,in
R2018 T7685 T7686 compound fat,pad
R2019 T7616 T7617 det the,strain
R2020 T7617 T7609 nsubj strain,displayed
R2021 T7618 T7617 compound B62D,strain
R2022 T7619 T7620 advmod highly,significant
R2023 T7686 T7684 compound pad,weights
R2024 T7620 T7621 amod significant,decreases
R2025 T7621 T7609 dobj decreases,displayed
R2026 T7687 T7681 auxpass were,observed
R2027 T7622 T7621 prep in,decreases
R2028 T7623 T7622 pobj adiposity,in
R2029 T7624 T7609 punct .,displayed
R2030 T7688 T7681 prep for,observed
R2031 T7626 T7627 nsubj B62D,was
R2032 T7689 T7690 det the,strains
R2033 T7628 T7629 det the,strain
R2034 T7629 T7627 attr strain,was
R2035 T7690 T7688 pobj strains,for
R2036 T7630 T7629 amod only,strain
R2037 T7631 T7632 advmod where,had
R2038 T7691 T7690 nmod B62P,strains
R2039 T7632 T7629 relcl had,strain
R2040 T7633 T7634 det both,sexes
R2041 T7634 T7632 nsubj sexes,had
R2042 T7692 T7691 cc and,B62P
R2043 T7635 T7636 amod significant,decreases
R2044 T7636 T7632 dobj decreases,had
R2045 T7637 T7636 prep in,decreases
R2046 T7638 T7637 pobj TF,in
R2047 T7639 T7638 punct ", ",TF
R2048 T7640 T7638 conj AI,TF
R2049 T7641 T7640 cc and,AI
R2050 T7693 T7691 conj B62PM,B62P
R2051 T7642 T7640 conj BMI,AI
R2052 T7643 T7627 punct .,was
R2053 T7694 T7695 punct (,Table
R2054 T7645 T7646 advmod Interestingly,seen
R2055 T7647 T7646 punct ", ",seen
R2056 T7695 T7681 parataxis Table,observed
R2057 T7648 T7649 det no,difference
R2058 T7649 T7646 nsubjpass difference,seen
R2059 T7650 T7649 prep in,difference
R2060 T7696 T7695 nummod 2,Table
R2061 T7651 T7650 pobj adiposity,in
R2062 T7652 T7646 auxpass was,seen
R2063 T7653 T7646 prep in,seen
R2064 T7697 T7695 punct ),Table
R2065 T7654 T7655 compound B62M,mice
R2066 T7655 T7653 pobj mice,in
R2067 T7656 T7646 punct .,seen
R2068 T7698 T7681 punct .,observed
R2069 T7658 T7659 det This,discordance
R2070 T7659 T7660 nsubj discordance,indicates
R2071 T7700 T7701 nmod HG.CAST,MMU2
R2072 T7661 T7662 det the,QTL
R2073 T7662 T7665 nsubjpass QTL,located
R2074 T7663 T7664 npadvmod leanness,promoting
R2075 T7701 T7702 nmod MMU2,panel
R2076 T7664 T7662 amod promoting,QTL
R2077 T7665 T7660 advcl located,indicates
R2078 T7703 T7704 npadvmod speed,congenic
R2079 T7704 T7702 amod congenic,panel
R2080 T7706 T7707 nmod HG2P,mice
R2081 T7772 T7769 conj gain,size
R2082 T7773 T7772 cc and,gain
R2083 T7774 T7772 conj NA,gain
R2084 T7707 T7710 nsubj mice,displayed
R2085 T7775 T7774 punct (,NA
R2086 T7776 T7777 advmod only,in
R2087 T7708 T7706 cc and,HG2P
R2088 T7777 T7774 prep in,NA
R2089 T7778 T7777 pobj females,in
R2090 T7779 T7757 punct ),decrease
R2091 T7709 T7706 conj HG2PM,HG2P
R2092 T7711 T7707 prep of,mice
R2093 T7780 T7757 punct ", ",decrease
R2094 T7781 T7782 mark while,decreases
R2095 T7782 T7757 advcl decreases,decrease
R2096 T7783 T7784 det a,QTL
R2097 T7712 T7713 det both,sexes
R2098 T7784 T7782 nsubj QTL,decreases
R2099 T7785 T7784 prep in,QTL
R2100 T7786 T7787 det the,region
R2101 T7713 T7711 pobj sexes,of
R2102 T7787 T7785 pobj region,in
R2103 T7788 T7787 compound HG2M,region
R2104 T7789 T7782 advmod significantly,decreases
R2105 T7714 T7715 amod significant,decreases
R2106 T7790 T7791 compound tail,length
R2107 T7715 T7710 dobj decreases,displayed
R2108 T7791 T7782 dobj length,decreases
R2109 T7716 T7715 prep in,decreases
R2110 T7792 T7755 punct .,indicate
R2111 T7717 T7718 amod post-weaning,weights
R2112 T7794 T7795 advcl Similar,seen
R2113 T7718 T7716 pobj weights,in
R2114 T7796 T7794 prep to,Similar
R2115 T7797 T7798 compound growth,traits
R2116 T7798 T7796 pobj traits,to
R2117 T7719 T7718 compound body,weights
R2118 T7799 T7800 det a,decrease
R2119 T7800 T7795 nsubjpass decrease,seen
R2120 T7801 T7800 amod general,decrease
R2121 T7720 T7718 cc and,weights
R2122 T7802 T7800 prep in,decrease
R2123 T7803 T7802 pobj GFP,in
R2124 T7721 T7722 compound growth,rates
R2125 T7804 T7803 punct ", ",GFP
R2126 T7805 T7803 conj MFP,GFP
R2127 T7806 T7805 punct ", ",MFP
R2128 T7722 T7718 conj rates,weights
R2129 T7807 T7805 conj RFP,MFP
R2130 T7808 T7807 punct ", ",RFP
R2131 T7723 T7724 punct (,Table
R2132 T7809 T7807 conj TF,RFP
R2133 T7810 T7809 cc and,TF
R2134 T7811 T7809 conj AI,TF
R2135 T7812 T7795 auxpass were,seen
R2136 T7724 T7710 parataxis Table,displayed
R2137 T7813 T7795 prep in,seen
R2138 T7814 T7815 nmod HG2P,mice
R2139 T7725 T7724 amod Additional,Table
R2140 T7815 T7813 pobj mice,in
R2141 T7816 T7814 cc and,HG2P
R2142 T7817 T7814 conj HG2PM,HG2P
R2143 T7726 T7724 nummod 3,Table
R2144 T7818 T7819 punct (,Region
R2145 T7819 T7795 parataxis Region,seen
R2146 T7820 T7819 nummod II,Region
R2147 T7821 T7819 punct ),Region
R2148 T7822 T7823 punct (,Table
R2149 T7727 T7724 punct ),Table
R2150 T7823 T7795 parataxis Table,seen
R2151 T7824 T7823 nummod 2,Table
R2152 T7825 T7823 punct ),Table
R2153 T7728 T7710 punct .,displayed
R2154 T7826 T7795 punct .,seen
R2155 T7828 T7829 det These,differences
R2156 T7730 T7731 prep In,displayed
R2157 T7829 T7830 nsubj differences,are
R2158 T7831 T7829 prep in,differences
R2159 T7832 T7831 pobj adiposity,in
R2160 T7732 T7730 pobj addition,In
R2161 T7833 T7830 advmod likely,are
R2162 T7834 T7835 amod pleiotropic,effects
R2163 T7835 T7830 attr effects,are
R2164 T7836 T7835 prep of,effects
R2165 T7733 T7731 punct ", ",displayed
R2166 T7837 T7838 det the,QTL
R2167 T7838 T7836 pobj QTL,of
R2168 T7734 T7735 det the,strain
R2169 T7839 T7838 compound growth,QTL
R2170 T7840 T7838 acl shared,QTL
R2171 T7841 T7840 prep between,shared
R2172 T7842 T7843 det these,strains
R2173 T7735 T7731 nsubj strain,displayed
R2174 T7843 T7841 pobj strains,between
R2175 T7844 T7843 nummod two,strains
R2176 T7736 T7735 compound HG2M,strain
R2177 T7845 T7830 punct .,are
R2178 T7847 T7848 advmod Surprisingly,displayed
R2179 T7737 T7738 advmod highly,significant
R2180 T7849 T7848 punct ", ",displayed
R2181 T7850 T7851 compound HG2M,mice
R2182 T7738 T7739 amod significant,decreases
R2183 T7851 T7848 nsubj mice,displayed
R2184 T7852 T7853 amod striking,differences
R2185 T7739 T7731 dobj decreases,displayed
R2186 T7853 T7848 dobj differences,displayed
R2187 T7854 T7853 compound sex,differences
R2188 T7855 T7853 prep in,differences
R2189 T7856 T7855 pobj adiposity,in
R2190 T7740 T7739 prep in,decreases
R2191 T7857 T7848 punct .,displayed
R2192 T7741 T7740 pobj length,in
R2193 T7859 T7860 nsubj Males,exhibited
R2194 T7861 T7862 det an,increase
R2195 T7742 T7731 punct ", ",displayed
R2196 T7862 T7860 dobj increase,exhibited
R2197 T7863 T7862 prep in,increase
R2198 T7864 T7863 pobj AI,in
R2199 T7865 T7866 punct (,0.0256
R2200 T7866 T7862 parataxis 0.0256,increase
R2201 T7867 T7866 nsubj P,0.0256
R2202 T7743 T7731 advcl similar,displayed
R2203 T7868 T7866 punct =,0.0256
R2204 T7869 T7866 punct ),0.0256
R2205 T7744 T7743 prep to,similar
R2206 T7870 T7862 prep with,increase
R2207 T7871 T7872 det a,decrease
R2208 T7872 T7870 pobj decrease,with
R2209 T7745 T7746 compound B62M,mice
R2210 T7873 T7872 prep in,decrease
R2211 T7874 T7873 pobj BMI,in
R2212 T7875 T7876 punct (,0.0462
R2213 T7746 T7744 pobj mice,to
R2214 T7876 T7872 parataxis 0.0462,decrease
R2215 T7877 T7876 nsubj P,0.0462
R2216 T7747 T7748 punct (,Table
R2217 T7748 T7731 parataxis Table,displayed
R2218 T7749 T7748 nummod 2,Table
R2219 T7750 T7748 punct ),Table
R2220 T7751 T7731 punct .,displayed
R2221 T7878 T7876 punct =,0.0462
R2222 T7879 T7876 punct ),0.0462
R2223 T7753 T7754 det These,results
R2224 T7880 T7860 cc and,exhibited
R2225 T7754 T7755 nsubj results,indicate
R2226 T7881 T7882 det the,opposite
R2227 T7882 T7884 nsubjpass opposite,seen
R2228 T7756 T7757 nsubj QTL,decrease
R2229 T7883 T7882 amod exact,opposite
R2230 T7884 T7860 conj seen,exhibited
R2231 T7885 T7884 auxpass was,seen
R2232 T7886 T7884 prep in,seen
R2233 T7757 T7755 advcl decrease,indicate
R2234 T7887 T7886 pobj females,in
R2235 T7888 T7889 punct (,0.0425
R2236 T7758 T7756 prep within,QTL
R2237 T7889 T7884 parataxis 0.0425,seen
R2238 T7890 T7891 dep AI,0.0001
R2239 T7891 T7889 dep 0.0001,0.0425
R2240 T7759 T7758 pobj Region,within
R2241 T7892 T7891 punct ", ",0.0001
R2242 T7893 T7891 nsubj P,0.0001
R2243 T7894 T7891 punct <,0.0001
R2244 T7895 T7889 punct ;,0.0425
R2245 T7760 T7759 nummod II,Region
R2246 T7896 T7889 dep BMI,0.0425
R2247 T7897 T7889 punct ", ",0.0425
R2248 T7761 T7756 acl shared,QTL
R2249 T7898 T7889 nsubj P,0.0425
R2250 T7899 T7889 punct =,0.0425
R2251 T7900 T7889 punct ),0.0425
R2252 T7901 T7902 punct (,Table
R2253 T7902 T7884 parataxis Table,seen
R2254 T7903 T7902 nummod 2,Table
R2255 T7762 T7761 prep between,shared
R2256 T7904 T7902 punct ),Table
R2257 T7905 T7884 punct .,seen
R2258 T7763 T7764 det the,strains
R2259 T7907 T7908 advmod Therefore,impacted
R2260 T7764 T7762 pobj strains,between
R2261 T7909 T7908 punct ", ",impacted
R2262 T7910 T7911 det the,QTL
R2263 T7911 T7908 nsubjpass QTL,impacted
R2264 T7765 T7764 nmod HG2P,strains
R2265 T7912 T7911 compound obesity,QTL
R2266 T7913 T7911 prep in,QTL
R2267 T7766 T7765 cc and,HG2P
R2268 T7914 T7915 det the,region
R2269 T7915 T7913 pobj region,in
R2270 T7916 T7915 nmod HG2M,region
R2271 T7767 T7765 conj HG2PM,HG2P
R2272 T7917 T7915 amod unique,region
R2273 T7918 T7915 punct (,region
R2274 T7919 T7915 appos Region,region
R2275 T7768 T7769 compound body,size
R2276 T7920 T7919 nummod IV,Region
R2277 T7921 T7908 punct ),impacted
R2278 T7922 T7908 auxpass is,impacted
R2279 T7769 T7757 dobj size,decrease
R2280 T7923 T7908 advmod profoundly,impacted
R2281 T7924 T7908 agent by,impacted
R2282 T7925 T7926 det the,presence
R2283 T7770 T7769 punct ", ",size
R2284 T7926 T7924 pobj presence,by
R2285 T7927 T7926 prep of,presence
R2286 T7771 T7772 compound weight,gain
R2287 T7928 T7927 pobj hg,of
R2288 T7929 T7908 punct .,impacted
R2289 T7983 T7977 cc and,B6
R2290 T7932 T7931 prep of,Confirmation
R2291 T7933 T7934 compound QTL,hg
R2292 T7934 T7936 compound hg,interactions
R2293 T7935 T7934 punct -,hg
R2294 T7984 T7977 conj HG,B6
R2295 T7936 T7932 pobj interactions,of
R2296 T7985 T7986 punct (,hg
R2297 T7938 T7939 det An,feature
R2298 T7939 T7941 nsubj feature,was
R2299 T7940 T7939 amod important,feature
R2300 T7986 T7984 parataxis hg,HG
R2301 T7942 T7939 prep of,feature
R2302 T7943 T7944 poss our,design
R2303 T7944 T7942 pobj design,of
R2304 T7945 T7944 amod experimental,design
R2305 T7946 T7947 det the,ability
R2306 T7987 T7986 compound hg,hg
R2307 T7947 T7941 attr ability,was
R2308 T7948 T7949 aux to,test
R2309 T7949 T7947 acl test,ability
R2310 T7988 T7986 punct /,hg
R2311 T7950 T7949 prep for,test
R2312 T7951 T7950 pobj interactions,for
R2313 T7952 T7951 prep between,interactions
R2314 T7989 T7986 punct ),hg
R2315 T7953 T7952 pobj QTL,between
R2316 T7954 T7949 prep in,test
R2317 T7990 T7941 punct .,was
R2318 T7955 T7956 det each,region
R2319 T7956 T7954 pobj region,in
R2320 T7957 T7958 compound MMU2,donor
R2321 T7958 T7956 compound donor,region
R2322 T7992 T7993 amod Significant,interactions
R2323 T7959 T7949 cc and,test
R2324 T7960 T7949 conj genotype,test
R2325 T7961 T7960 prep at,genotype
R2326 T7962 T7963 det the,locus
R2327 T7993 T7994 nsubjpass interactions,viewed
R2328 T7963 T7961 pobj locus,at
R2329 T7964 T7963 compound HG,locus
R2330 T7965 T7960 punct ", ",genotype
R2331 T7995 T7993 prep between,interactions
R2332 T7966 T7967 mark since,introgressed
R2333 T7996 T7997 compound donor,region
R2334 T7967 T7960 advcl introgressed,genotype
R2335 T7968 T7969 amod identical,regions
R2336 T7997 T7995 pobj region,between
R2337 T7969 T7967 nsubjpass regions,introgressed
R2338 T7970 T7969 compound donor,regions
R2339 T7971 T7967 auxpass were,introgressed
R2340 T7998 T7997 cc and,region
R2341 T7972 T7967 prep on,introgressed
R2342 T7973 T7974 nummod two,backgrounds
R2343 T7974 T7972 pobj backgrounds,on
R2344 T7999 T8000 compound HG,genotype
R2345 T7975 T7974 amod genetic,backgrounds
R2346 T7976 T7974 punct ", ",backgrounds
R2347 T8000 T7997 conj genotype,region
R2348 T7977 T7974 appos B6,backgrounds
R2349 T7978 T7979 punct (,+
R2350 T8001 T7994 auxpass were,viewed
R2351 T7979 T7977 punct +,B6
R2352 T7980 T7979 punct +,+
R2353 T8002 T7994 prep as,viewed
R2354 T7981 T7979 punct /,+
R2355 T7982 T7979 punct ),+
R2356 T8003 T8004 amod strong,evidence
R2357 T8004 T8002 pobj evidence,as
R2358 T8089 T8086 dobj set,represents
R2359 T8005 T8006 mark that,reside
R2360 T8090 T8089 prep of,set
R2361 T8091 T8092 amod linked,QTL
R2362 T8092 T8090 pobj QTL,of
R2363 T8006 T8004 acl reside,evidence
R2364 T8093 T8092 prep between,QTL
R2365 T8094 T8095 nummod 74.9,Mbp
R2366 T8095 T8093 pobj Mbp,between
R2367 T8096 T8094 cc and,74.9
R2368 T8007 T8008 compound hg,QTL
R2369 T8097 T8094 conj 181.8,74.9
R2370 T8098 T8089 prep within,set
R2371 T8008 T8006 nsubj QTL,reside
R2372 T8099 T8100 det the,regions
R2373 T8100 T8098 pobj regions,within
R2374 T8101 T8100 nmod 2M,regions
R2375 T8009 T8008 compound modifier,QTL
R2376 T8102 T8101 cc and,2M
R2377 T8103 T8101 conj 2D,2M
R2378 T8104 T8100 compound donor,regions
R2379 T8010 T8006 prep within,reside
R2380 T8105 T8100 punct (,regions
R2381 T8106 T8107 nmod Region,III
R2382 T8107 T8100 appos III,regions
R2383 T8011 T8012 det that,region
R2384 T8108 T8109 punct –,V
R2385 T8109 T8107 prep V,III
R2386 T8110 T8100 punct ),regions
R2387 T8012 T8010 pobj region,within
R2388 T8111 T8100 punct ", ",regions
R2389 T8112 T8113 dep some,interact
R2390 T8113 T8100 relcl interact,regions
R2391 T8013 T8012 amod unique,region
R2392 T8114 T8112 prep of,some
R2393 T8115 T8114 pobj which,of
R2394 T8116 T8113 prep with,interact
R2395 T8014 T8012 amod genomic,region
R2396 T8117 T8116 pobj hg,with
R2397 T8118 T8073 punct .,hypothesized
R2398 T8015 T7994 punct .,viewed
R2399 T8120 T8121 advcl Following,expected
R2400 T8122 T8123 det this,logic
R2401 T8017 T8018 prep In,were
R2402 T8123 T8120 dobj logic,Following
R2403 T8124 T8121 nsubj we,expected
R2404 T8125 T8126 nsubj one,exhibit
R2405 T8126 T8121 advcl exhibit,expected
R2406 T8127 T8125 cc or,one
R2407 T8128 T8125 conj both,one
R2408 T8129 T8125 prep of,one
R2409 T8019 T8020 det the,analysis
R2410 T8130 T8131 det these,strains
R2411 T8131 T8129 pobj strains,of
R2412 T8132 T8126 aux would,exhibit
R2413 T8133 T8134 nmod donor,region
R2414 T8134 T8135 nmod region,interactions
R2415 T8020 T8017 pobj analysis,In
R2416 T8135 T8126 dobj interactions,exhibit
R2417 T8136 T8134 prep by,region
R2418 T8137 T8138 compound HG,genotype
R2419 T8021 T8020 amod original,analysis
R2420 T8138 T8136 pobj genotype,by
R2421 T8022 T8020 compound linkage,analysis
R2422 T8139 T8121 punct .,expected
R2423 T8023 T8024 det the,mode
R2424 T8141 T8142 advmod Unfortunately,were
R2425 T8024 T8018 nsubj mode,were
R2426 T8143 T8142 punct ", ",were
R2427 T8144 T8142 nsubj we,were
R2428 T8025 T8024 prep of,mode
R2429 T8145 T8142 acomp unable,were
R2430 T8146 T8147 aux to,characterize
R2431 T8147 T8145 xcomp characterize,unable
R2432 T8026 T8027 compound gene,action
R2433 T8148 T8149 compound HG2D,mice
R2434 T8149 T8147 dobj mice,characterize
R2435 T8027 T8025 pobj action,of
R2436 T8150 T8142 punct .,were
R2437 T8152 T8153 advmod However,seen
R2438 T8028 T8024 cc and,mode
R2439 T8154 T8153 punct ", ",seen
R2440 T8155 T8156 mark as,noted
R2441 T8029 T8030 amod peak,location
R2442 T8156 T8153 advcl noted,seen
R2443 T8157 T8156 advmod above,noted
R2444 T8158 T8153 punct ", ",seen
R2445 T8030 T8024 conj location,mode
R2446 T8159 T8160 amod strong,effects
R2447 T8160 T8153 nsubjpass effects,seen
R2448 T8161 T8162 npadvmod sex,specific
R2449 T8031 T8030 prep of,location
R2450 T8162 T8160 amod specific,effects
R2451 T8163 T8162 punct -,specific
R2452 T8032 T8031 pobj Wg2,of
R2453 T8164 T8153 auxpass were,seen
R2454 T8165 T8153 prep in,seen
R2455 T8166 T8167 compound HG2M,mice
R2456 T8033 T8018 acomp dependent,were
R2457 T8167 T8165 pobj mice,in
R2458 T8168 T8153 punct .,seen
R2459 T8170 T8171 amod Significant,interactions
R2460 T8171 T8183 nsubjpass interactions,identified
R2461 T8172 T8173 nmod 2M,region
R2462 T8034 T8033 prep on,dependent
R2463 T8173 T8171 nmod region,interactions
R2464 T8174 T8173 nmod donor,region
R2465 T8035 T8036 det the,presence
R2466 T8175 T8173 prep by,region
R2467 T8036 T8034 pobj presence,on
R2468 T8176 T8177 compound HG,genotype
R2469 T8177 T8175 pobj genotype,by
R2470 T8037 T8036 prep of,presence
R2471 T8178 T8173 prep by,region
R2472 T8179 T8178 pobj sex,by
R2473 T8180 T8181 nummod three,way
R2474 T8038 T8037 pobj hg,of
R2475 T8181 T8171 compound way,interactions
R2476 T8182 T8181 punct -,way
R2477 T8039 T8040 punct [,24
R2478 T8184 T8171 prep for,interactions
R2479 T8185 T8184 pobj AI,for
R2480 T8040 T8018 parataxis 24,were
R2481 T8186 T8187 punct (,Figure
R2482 T8187 T8185 parataxis Figure,AI
R2483 T8188 T8189 nsubj P,0.0004
R2484 T8041 T8040 punct ],24
R2485 T8189 T8187 ccomp 0.0004,Figure
R2486 T8190 T8189 punct =,0.0004
R2487 T8191 T8187 punct ;,Figure
R2488 T8042 T8043 punct (,Table
R2489 T8192 T8187 nummod 4,Figure
R2490 T8193 T8187 punct ),Figure
R2491 T8194 T8185 cc and,AI
R2492 T8043 T8018 parataxis Table,were
R2493 T8044 T8043 nummod 1,Table
R2494 T8045 T8043 punct ),Table
R2495 T8195 T8185 conj TF,AI
R2496 T8046 T8018 punct .,were
R2497 T8196 T8183 auxpass were,identified
R2498 T8197 T8198 punct (,Table
R2499 T8048 T8049 prep In,tested
R2500 T8198 T8183 parataxis Table,identified
R2501 T8199 T8198 nummod 3,Table
R2502 T8200 T8198 punct ),Table
R2503 T8201 T8183 punct .,identified
R2504 T8050 T8051 det the,study
R2505 T8203 T8204 det The,basis
R2506 T8204 T8205 nsubj basis,was
R2507 T8051 T8048 pobj study,In
R2508 T8206 T8204 prep of,basis
R2509 T8207 T8208 det these,interactions
R2510 T8208 T8206 pobj interactions,of
R2511 T8209 T8210 det a,decrease
R2512 T8052 T8051 amod present,study
R2513 T8210 T8205 attr decrease,was
R2514 T8211 T8210 prep in,decrease
R2515 T8212 T8213 compound HG2M,female
R2516 T8213 T8211 pobj female,in
R2517 T8053 T8049 punct ", ",tested
R2518 T8214 T8210 cc and,decrease
R2519 T8215 T8216 det an,increase
R2520 T8216 T8217 nmod increase,adiposity
R2521 T8054 T8055 advmod only,mice
R2522 T8217 T8210 conj adiposity,decrease
R2523 T8218 T8216 prep in,increase
R2524 T8219 T8218 pobj HG2M,in
R2525 T8055 T8058 nsubjpass mice,characterized
R2526 T8220 T8219 amod male,HG2M
R2527 T8221 T8210 punct ", ",decrease
R2528 T8222 T8210 prep with,decrease
R2529 T8056 T8055 amod homozygous,mice
R2530 T8223 T8224 det no,differences
R2531 T8224 T8222 pobj differences,with
R2532 T8225 T8224 prep in,differences
R2533 T8057 T8055 amod congenic,mice
R2534 T8226 T8227 compound fat,accumulation
R2535 T8227 T8225 pobj accumulation,in
R2536 T8058 T8049 ccomp characterized,tested
R2537 T8228 T8224 prep across,differences
R2538 T8059 T8058 auxpass were,characterized
R2539 T8229 T8230 compound B62M,sexes
R2540 T8230 T8228 pobj sexes,across
R2541 T8060 T8049 punct ", ",tested
R2542 T8231 T8205 punct .,was
R2543 T8233 T8234 amod Significant,interactions
R2544 T8061 T8049 advmod thus,tested
R2545 T8234 T8256 nsubjpass interactions,seen
R2546 T8235 T8236 nmod 2PM,region
R2547 T8236 T8238 nmod region,way
R2548 T8062 T8049 punct ", ",tested
R2549 T8237 T8236 nmod donor,region
R2550 T8238 T8234 nmod way,interactions
R2551 T8239 T8236 prep by,region
R2552 T8063 T8064 det the,effects
R2553 T8240 T8241 compound HG,genotype
R2554 T8241 T8239 pobj genotype,by
R2555 T8064 T8049 nsubjpass effects,tested
R2556 T8242 T8238 nummod two,way
R2557 T8243 T8238 punct -,way
R2558 T8244 T8238 cc and,way
R2559 T8065 T8064 amod overdominant,effects
R2560 T8245 T8246 nmod 2PM,region
R2561 T8246 T8248 nmod region,way
R2562 T8247 T8246 nmod donor,region
R2563 T8248 T8238 conj way,way
R2564 T8249 T8246 prep by,region
R2565 T8250 T8251 compound HG,genotype
R2566 T8066 T8064 prep of,effects
R2567 T8251 T8249 pobj genotype,by
R2568 T8252 T8246 prep by,region
R2569 T8253 T8252 pobj sex,by
R2570 T8067 T8066 pobj Wg2,of
R2571 T8254 T8248 nummod three,way
R2572 T8255 T8248 punct -,way
R2573 T8068 T8049 auxpass were,tested
R2574 T8257 T8256 auxpass were,seen
R2575 T8258 T8256 advmod also,seen
R2576 T8069 T8049 neg not,tested
R2577 T8259 T8256 prep for,seen
R2578 T8260 T8259 pobj TF,for
R2579 T8261 T8260 cc and,TF
R2580 T8070 T8049 punct .,tested
R2581 T8262 T8260 conj AI,TF
R2582 T8263 T8264 punct (,Table
R2583 T8264 T8256 parataxis Table,seen
R2584 T8072 T8073 advmod However,hypothesized
R2585 T8265 T8264 nummod 3,Table
R2586 T8266 T8264 punct ),Table
R2587 T8267 T8256 punct .,seen
R2588 T8074 T8073 punct ", ",hypothesized
R2589 T8269 T8270 prep In,observed
R2590 T8271 T8269 pobj addition,In
R2591 T8272 T8270 punct ", ",observed
R2592 T8075 T8076 mark since,differed
R2593 T8273 T8274 amod significant,interactions
R2594 T8274 T8270 nsubjpass interactions,observed
R2595 T8076 T8073 advcl differed,hypothesized
R2596 T8275 T8276 nmod 2P,region
R2597 T8276 T8274 nmod region,interactions
R2598 T8277 T8276 nmod donor,region
R2599 T8077 T8078 poss its,location
R2600 T8278 T8279 punct ×,genotype
R2601 T8279 T8276 prep genotype,region
R2602 T8280 T8279 compound HG,genotype
R2603 T8078 T8076 nsubj location,differed
R2604 T8281 T8270 auxpass were,observed
R2605 T8282 T8270 prep for,observed
R2606 T8283 T8284 det all,traits
R2607 T8079 T8078 amod original,location
R2608 T8284 T8282 pobj traits,for
R2609 T8285 T8284 acl listed,traits
R2610 T8286 T8270 punct ", ",observed
R2611 T8080 T8078 compound peak,location
R2612 T8287 T8288 mark although,reached
R2613 T8288 T8270 advcl reached,observed
R2614 T8289 T8290 det some,traits
R2615 T8290 T8288 nsubj traits,reached
R2616 T8291 T8288 aux did,reached
R2617 T8292 T8288 dobj significance,reached
R2618 T8081 T8076 advcl dependent,differed
R2619 T8293 T8288 prep at,reached
R2620 T8294 T8295 det the,0.0071
R2621 T8295 T8293 pobj 0.0071,at
R2622 T8082 T8081 prep on,dependent
R2623 T8296 T8295 amod critical,0.0071
R2624 T8297 T8295 nsubj P,0.0071
R2625 T8298 T8295 punct <,0.0071
R2626 T8083 T8082 pobj background,on
R2627 T8299 T8300 punct (,Table
R2628 T8300 T8270 parataxis Table,observed
R2629 T8084 T8073 nsubj we,hypothesized
R2630 T8085 T8086 mark that,represents
R2631 T8086 T8073 ccomp represents,hypothesized
R2632 T8301 T8300 nummod 3,Table
R2633 T8302 T8300 punct ),Table
R2634 T8087 T8086 nsubj Wg2,represents
R2635 T8303 T8270 punct .,observed
R2636 T8088 T8089 det a,set
R2637 T8305 T8306 det The,basis
R2638 T8306 T8307 nsubj basis,was
R2639 T8308 T8306 prep for,basis
R2640 T8309 T8310 det each,interaction
R2641 T8310 T8308 pobj interaction,for
R2642 T8311 T8312 det a,decrease
R2643 T8312 T8307 attr decrease,was
R2644 T8313 T8312 prep in,decrease
R2645 T8314 T8313 pobj phenotype,in
R2646 T8315 T8312 prep in,decrease
R2647 T8316 T8315 pobj HG2P,in
R2648 T8317 T8312 prep compared,decrease
R2649 T8318 T8317 prep to,compared
R2650 T8319 T8318 pobj HGC,to
R2651 T8320 T8312 cc and,decrease
R2652 T8321 T8322 det no,difference
R2653 T8322 T8312 conj difference,decrease
R2654 T8323 T8322 prep between,difference
R2655 T8324 T8323 pobj B62P,between
R2656 T8325 T8324 cc and,B62P
R2657 T8326 T8324 conj B6C,B62P
R2658 T8327 T8307 punct .,was
R2659 T8329 T8330 advmod Together,confirm
R2660 T8331 T8332 det these,data
R2661 T8332 T8330 nsubj data,confirm
R2662 T8333 T8334 mark that,modify
R2663 T8334 T8330 ccomp modify,confirm
R2664 T8335 T8336 compound MMU2,QTL
R2665 T8336 T8334 nsubj QTL,modify
R2666 T8337 T8338 det the,effects
R2667 T8338 T8334 dobj effects,modify
R2668 T8339 T8338 prep of,effects
R2669 T8340 T8341 det the,deletion
R2670 T8341 T8339 pobj deletion,of
R2671 T8342 T8341 compound hg,deletion
R2672 T8343 T8330 punct .,confirm
R2673 T11091 T11092 npadvmod Speed,congenic
R2674 T11092 T11093 amod congenic,strains
R2675 T11094 T11093 prep for,strains
R2676 T11095 T11094 pobj QTL,for
R2677 T11096 T11093 prep on,strains
R2678 T11097 T11098 nmod MMU,1
R2679 T11098 T11096 pobj 1,on
R2680 T11099 T11098 punct ", ",1
R2681 T11100 T11098 conj 8,1
R2682 T11101 T11100 punct ", ",8
R2683 T11102 T11100 conj 9,8
R2684 T11103 T11102 punct ", ",9
R2685 T11104 T11102 conj 11,9
R2686 T11105 T11104 cc and,11
R2687 T11106 T11104 conj 17,11
R2688 T11110 T11111 nsubj Q1Ucd1,was
R2689 T11112 T11110 acl affecting,Q1Ucd1
R2690 T11113 T11112 dobj G26,affecting
R2691 T11114 T11115 det the,significant
R2692 T11115 T11111 attr significant,was
R2693 T11116 T11115 amod least,significant
R2694 T11117 T11115 prep of,significant
R2695 T11118 T11119 det any,QTL
R2696 T11119 T11117 pobj QTL,of
R2697 T11120 T11119 acl identified,QTL
R2698 T11121 T11120 prep in,identified
R2699 T11122 T11123 det the,intercross
R2700 T11123 T11121 pobj intercross,in
R2701 T11124 T11123 amod original,intercross
R2702 T11125 T11111 cc and,was
R2703 T11126 T11127 advmod only,reached
R2704 T11127 T11111 conj reached,was
R2705 T11128 T11129 det a,level
R2706 T11129 T11127 dobj level,reached
R2707 T11130 T11129 amod suggestive,level
R2708 T11131 T11129 prep of,level
R2709 T11132 T11131 pobj significance,of
R2710 T11133 T11134 punct (,0.05
R2711 T11134 T11127 parataxis 0.05,reached
R2712 T11135 T11136 nsubj LOD,2.46
R2713 T11136 T11134 ccomp 2.46,0.05
R2714 T11137 T11136 punct =,2.46
R2715 T11138 T11134 punct ", ",0.05
R2716 T11139 T11134 nsubj P,0.05
R2717 T11140 T11134 punct <,0.05
R2718 T11141 T11134 punct ),0.05
R2719 T11142 T11143 punct [,26
R2720 T11143 T11127 parataxis 26,reached
R2721 T11144 T11143 punct ],26
R2722 T11145 T11111 punct .,was
R2723 T11147 T11148 prep In,had
R2724 T11149 T11147 pobj accordance,In
R2725 T11150 T11148 punct ", ",had
R2726 T11151 T11152 compound HG1,mice
R2727 T11152 T11148 nsubj mice,had
R2728 T11153 T11154 amod small,differences
R2729 T11154 T11148 dobj differences,had
R2730 T11155 T11154 prep in,differences
R2731 T11156 T11157 det all,traits
R2732 T11157 T11155 pobj traits,in
R2733 T11158 T11157 nmod growth,traits
R2734 T11159 T11158 cc and,growth
R2735 T11160 T11158 conj length,growth
R2736 T11161 T11148 punct .,had
R2737 T11163 T11164 nsubj NA,was
R2738 T11165 T11163 prep in,NA
R2739 T11166 T11167 preconj both,sexes
R2740 T11167 T11165 pobj sexes,in
R2741 T11168 T11163 cc and,NA
R2742 T11169 T11170 nmod 2WK,6WK
R2743 T11170 T11163 conj 6WK,NA
R2744 T11171 T11170 punct ", ",6WK
R2745 T11172 T11170 nmod 3WK,6WK
R2746 T11173 T11170 punct ", ",6WK
R2747 T11174 T11170 cc and,6WK
R2748 T11175 T11176 compound tail,length
R2749 T11176 T11170 conj length,6WK
R2750 T11177 T11170 prep in,6WK
R2751 T11178 T11177 pobj females,in
R2752 T11179 T11164 acomp significant,was
R2753 T11180 T11164 prep at,was
R2754 T11181 T11182 det a,0.005
R2755 T11182 T11180 pobj 0.005,at
R2756 T11183 T11182 amod critical,0.005
R2757 T11184 T11182 nsubj P,0.005
R2758 T11185 T11182 punct <,0.005
R2759 T11186 T11187 punct (,Table
R2760 T11187 T11164 parataxis Table,was
R2761 T11188 T11187 nummod 4,Table
R2762 T11189 T11187 punct ),Table
R2763 T11190 T11164 punct .,was
R2764 T11192 T11193 det The,difference
R2765 T11193 T11195 nsubj difference,was
R2766 T11194 T11193 amod only,difference
R2767 T11196 T11193 prep in,difference
R2768 T11197 T11196 pobj adiposity,in
R2769 T11198 T11199 det a,decrease
R2770 T11199 T11195 attr decrease,was
R2771 T11200 T11199 amod significant,decrease
R2772 T11201 T11199 prep in,decrease
R2773 T11202 T11203 amod male,MFP
R2774 T11203 T11201 pobj MFP,in
R2775 T11204 T11205 punct (,Table
R2776 T11205 T11195 parataxis Table,was
R2777 T11206 T11205 nummod 5,Table
R2778 T11207 T11205 punct ),Table
R2779 T11208 T11195 punct .,was
R278 T2716 T2717 det The,use
R2780 T11210 T11211 det The,capture
R2781 T11211 T11213 nsubj capture,adds
R2782 T11212 T11211 amod successful,capture
R2783 T11214 T11211 cc and,capture
R2784 T11215 T11211 conj confirmation,capture
R2785 T11216 T11211 prep of,capture
R2786 T11217 T11218 det the,QTL
R2787 T11218 T11216 pobj QTL,of
R2788 T11219 T11220 amod small,effect
R2789 T11220 T11218 compound effect,QTL
R279 T2717 T2718 nsubj use,provided
R2790 T11221 T11222 compound Q1Ucd1,w26
R2791 T11222 T11218 compound w26,QTL
R2792 T11223 T11222 punct -,w26
R2793 T11224 T11213 dobj support,adds
R2794 T11225 T11213 prep to,adds
R2795 T11226 T11225 pcomp pursuing,to
R2796 T11227 T11226 dobj QTL,pursuing
R2797 T11228 T11227 acl identified,QTL
R2798 T11229 T11228 prep at,identified
R2799 T11230 T11231 amod suggestive,levels
R280 T2719 T2717 prep of,use
R2800 T11231 T11229 pobj levels,at
R2801 T11232 T11231 prep of,levels
R2802 T11233 T11234 amod statistical,confidence
R2803 T11234 T11232 pobj confidence,of
R2804 T11235 T11228 prep from,identified
R2805 T11236 T11237 compound genome,scans
R2806 T11237 T11235 pobj scans,from
R2807 T11238 T11213 punct .,adds
R2808 T11242 T11243 nsubjpass Markers,linked
R2809 T11244 T11242 prep on,Markers
R281 T2720 T2721 compound mouse,models
R2810 T11245 T11244 pobj MMU8,on
R2811 T11246 T11243 auxpass were,linked
R2812 T11247 T11243 prep with,linked
R2813 T11248 T11247 pobj G29,with
R2814 T11249 T11243 prep in,linked
R2815 T11250 T11251 det the,intercross
R2816 T11251 T11249 pobj intercross,in
R2817 T11252 T11251 amod original,intercross
R2818 T11253 T11254 punct [,24
R2819 T11254 T11243 parataxis 24,linked
R282 T2721 T2719 pobj models,of
R2820 T11255 T11254 punct ],24
R2821 T11256 T11243 punct .,linked
R2822 T11258 T11259 det This,QTL
R2823 T11259 T11260 nsubj QTL,was
R2824 T11261 T11260 acomp small,was
R2825 T11262 T11260 punct ", ",was
R2826 T11263 T11264 advmod only,accounting
R2827 T11264 T11260 advcl accounting,was
R2828 T11265 T11264 prep for,accounting
R2829 T11266 T11267 nummod 4.3,%
R283 T2722 T2718 aux has,provided
R2830 T11267 T11265 pobj %,for
R2831 T11268 T11267 prep of,%
R2832 T11269 T11270 det the,variance
R2833 T11270 T11268 pobj variance,of
R2834 T11271 T11270 amod phenotypic,variance
R2835 T11272 T11260 punct .,was
R2836 T11274 T11275 advmod Interestingly,detected
R2837 T11275 T11285 ccomp detected,were
R2838 T11276 T11275 punct ", ",detected
R2839 T11277 T11275 prep in,detected
R284 T2723 T2724 amod valuable,insight
R2840 T11278 T11279 compound HG8,mice
R2841 T11279 T11277 pobj mice,in
R2842 T11280 T11281 det no,differences
R2843 T11281 T11275 nsubjpass differences,detected
R2844 T11282 T11281 prep in,differences
R2845 T11283 T11282 pobj growth,in
R2846 T11284 T11275 auxpass were,detected
R2847 T11286 T11285 punct ;,were
R2848 T11287 T11285 advmod however,were
R2849 T11288 T11285 punct ", ",were
R285 T2724 T2718 dobj insight,provided
R2850 T11289 T11285 nsubj they,were
R2851 T11290 T11291 advmod significantly,leaner
R2852 T11291 T11285 acomp leaner,were
R2853 T11292 T11291 prep than,leaner
R2854 T11293 T11292 pobj controls,than
R2855 T11294 T11295 punct (,Table
R2856 T11295 T11285 parataxis Table,were
R2857 T11296 T11295 nummod 5,Table
R2858 T11297 T11295 punct ),Table
R2859 T11298 T11285 punct .,were
R286 T2725 T2724 prep into,insight
R2860 T11300 T11301 prep In,was
R2861 T11302 T11300 pobj males,In
R2862 T11303 T11304 det a,decrease
R2863 T11304 T11306 nsubjpass decrease,detected
R2864 T11305 T11304 amod general,decrease
R2865 T11306 T11301 ccomp detected,was
R2866 T11307 T11304 prep in,decrease
R2867 T11308 T11309 compound fat,pad
R2868 T11309 T11310 compound pad,mass
R2869 T11310 T11307 pobj mass,in
R287 T2726 T2727 det the,etiology
R2870 T11311 T11310 punct ", ",mass
R2871 T11312 T11310 conj TF,mass
R2872 T11313 T11312 cc and,TF
R2873 T11314 T11312 conj AI,TF
R2874 T11315 T11306 auxpass was,detected
R2875 T11316 T11301 punct ;,was
R2876 T11317 T11301 advmod however,was
R2877 T11318 T11301 punct ", ",was
R2878 T11319 T11320 advmod only,MFP
R2879 T11320 T11301 nsubj MFP,was
R288 T2727 T2725 pobj etiology,into
R2880 T11321 T11301 acomp significant,was
R2881 T11322 T11301 prep at,was
R2882 T11323 T11324 det a,0.005
R2883 T11324 T11322 pobj 0.005,at
R2884 T11325 T11324 amod critical,0.005
R2885 T11326 T11324 nsubj P,0.005
R2886 T11327 T11324 punct <,0.005
R2887 T11328 T11301 punct .,was
R2888 T11330 T11331 amod Male,AI
R2889 T11331 T11332 nsubj AI,was
R289 T2728 T2727 prep of,etiology
R2890 T11333 T11334 advmod nearly,significant
R2891 T11334 T11332 acomp significant,was
R2892 T11335 T11332 prep at,was
R2893 T11336 T11337 det a,0.0082
R2894 T11337 T11335 pobj 0.0082,at
R2895 T11338 T11337 amod nominal,0.0082
R2896 T11339 T11337 nsubj P,0.0082
R2897 T11340 T11337 punct =,0.0082
R2898 T11341 T11332 punct .,was
R2899 T11343 T11344 amod Larger,decreases
R290 T2729 T2730 amod monogenic,syndromes
R2900 T11344 T11345 nsubjpass decreases,seen
R2901 T11346 T11344 prep in,decreases
R2902 T11347 T11348 compound fat,mass
R2903 T11348 T11346 pobj mass,in
R2904 T11349 T11345 auxpass were,seen
R2905 T11350 T11345 prep in,seen
R2906 T11351 T11352 compound HG8,females
R2907 T11352 T11350 pobj females,in
R2908 T11353 T11345 punct ", ",seen
R2909 T11354 T11355 mark with,detected
R291 T2730 T2728 pobj syndromes,of
R2910 T11355 T11345 advcl detected,seen
R2911 T11356 T11357 amod significant,decreases
R2912 T11357 T11355 nsubj decreases,detected
R2913 T11358 T11355 prep for,detected
R2914 T11359 T11358 pobj GFP,for
R2915 T11360 T11359 punct ", ",GFP
R2916 T11361 T11359 conj MFP,GFP
R2917 T11362 T11361 cc and,MFP
R2918 T11363 T11361 conj AI,MFP
R2919 T11364 T11345 punct .,seen
R292 T2731 T2730 acl caused,syndromes
R2920 T11366 T11367 advmod Additionally,were
R2921 T11368 T11367 punct ", ",were
R2922 T11369 T11367 nsubj RFP,were
R2923 T11370 T11369 cc and,RFP
R2924 T11371 T11369 conj TF,RFP
R2925 T11372 T11373 advmod nearly,significant
R2926 T11373 T11367 acomp significant,were
R2927 T11374 T11367 prep with,were
R2928 T11375 T11376 amod nominal,values
R2929 T11376 T11374 pobj values,with
R293 T2732 T2731 agent by,caused
R2930 T11377 T11376 compound P,values
R2931 T11378 T11376 prep of,values
R2932 T11379 T11378 pobj 0.0208,of
R2933 T11380 T11379 cc and,0.0208
R2934 T11381 T11379 conj 0.0153,0.0208
R2935 T11382 T11367 punct ", ",were
R2936 T11383 T11367 advmod respectively,were
R2937 T11384 T11367 punct .,were
R2938 T11386 T11387 compound HG8,mice
R2939 T11387 T11388 nsubj mice,represent
R294 T2733 T2734 amod single,mutations
R2940 T11389 T11390 det a,model
R2941 T11390 T11388 dobj model,represent
R2942 T11391 T11390 amod lean,model
R2943 T11392 T11390 amod congenic,model
R2944 T11393 T11394 prep in,protect
R2945 T11394 T11390 relcl protect,model
R2946 T11395 T11393 pobj which,in
R2947 T11396 T11397 compound CAST,alleles
R2948 T11397 T11394 nsubj alleles,protect
R2949 T11398 T11394 prep against,protect
R295 T2734 T2732 pobj mutations,by
R2950 T11399 T11400 compound fat,accumulation
R2951 T11400 T11398 pobj accumulation,against
R2952 T11401 T11388 punct .,represent
R2953 T11405 T11406 compound CAST,alleles
R2954 T11406 T11407 nsubjpass alleles,found
R2955 T11408 T11406 prep in,alleles
R2956 T11409 T11410 det the,region
R2957 T11410 T11408 pobj region,in
R2958 T11411 T11410 amod proximal,region
R2959 T11412 T11410 prep of,region
R296 T2735 T2734 compound gene,mutations
R2960 T11413 T11412 pobj MMU9,of
R2961 T11414 T11407 auxpass were,found
R2962 T11415 T11407 advmod previously,found
R2963 T11416 T11417 aux to,linked
R2964 T11417 T11407 xcomp linked,found
R2965 T11418 T11417 auxpass be,linked
R2966 T11419 T11417 prep with,linked
R2967 T11420 T11421 det an,increase
R2968 T11421 T11419 pobj increase,with
R2969 T11422 T11421 prep in,increase
R297 T2736 T2718 punct .,provided
R2970 T11423 T11424 compound body,fat
R2971 T11424 T11425 compound fat,percentage
R2972 T11425 T11422 pobj percentage,in
R2973 T11426 T11421 cc and,increase
R2974 T11427 T11428 det a,decrease
R2975 T11428 T11421 conj decrease,increase
R2976 T11429 T11428 prep in,decrease
R2977 T11430 T11431 compound femur,length
R2978 T11431 T11429 pobj length,in
R2979 T11432 T11433 punct [,24
R298 T2738 T2739 advmod However,mimic
R2980 T11433 T11407 parataxis 24,found
R2981 T11434 T11433 punct ],24
R2982 T11435 T11407 punct .,found
R2983 T11437 T11438 det The,effects
R2984 T11438 T11439 nsubj effects,appeared
R2985 T11440 T11441 aux to,be
R2986 T11441 T11439 xcomp be,appeared
R2987 T11442 T11443 det the,result
R2988 T11443 T11441 attr result,be
R2989 T11444 T11443 prep of,result
R299 T2740 T2739 punct ", ",mimic
R2990 T11445 T11446 nummod two,QTL
R2991 T11446 T11444 pobj QTL,of
R2992 T11447 T11446 amod linked,QTL
R2993 T11448 T11446 punct ", ",QTL
R2994 T11449 T11446 appos Carfhg2,QTL
R2995 T11450 T11449 prep at,Carfhg2
R2996 T11451 T11452 nummod 10,cM
R2997 T11452 T11450 pobj cM,at
R2998 T11453 T11449 cc and,Carfhg2
R2999 T11454 T11449 conj Feml2,Carfhg2
R300 T2741 T2742 amod such,models
R3000 T11455 T11454 prep at,Feml2
R3001 T11456 T11457 nummod 20,cM
R3002 T11457 T11455 pobj cM,at
R3003 T11535 T11533 punct ", ",increased
R3004 T11458 T11446 punct ", ",QTL
R3005 T11536 T11533 nsubjpass GFP,increased
R3006 T11537 T11536 punct ", ",GFP
R3007 T11459 T11446 prep instead,QTL
R3008 T11538 T11536 conj RFP,GFP
R3009 T11539 T11538 punct ", ",RFP
R301 T2742 T2739 nsubj models,mimic
R3010 T11460 T11459 pcomp of,instead
R3011 T11540 T11538 conj FFP,RFP
R3012 T11461 T11459 pobj one,instead
R3013 T11541 T11540 cc and,FFP
R3014 T11542 T11540 conj AI,FFP
R3015 T11462 T11463 advmod pleiotropically,impacting
R3016 T11543 T11533 auxpass were,increased
R3017 T11544 T11533 prep by,increased
R3018 T11545 T11546 nummod 29.0,%
R3019 T11463 T11461 acl impacting,one
R302 T2743 T2739 aux do,mimic
R3020 T11546 T11544 pobj %,by
R3021 T11547 T11546 punct ", ",%
R3022 T11464 T11465 det both,traits
R3023 T11548 T11549 nummod 51.2,%
R3024 T11549 T11546 conj %,%
R3025 T11465 T11463 dobj traits,impacting
R3026 T11550 T11549 punct ", ",%
R3027 T11551 T11552 nummod 42.9,%
R3028 T11552 T11549 conj %,%
R3029 T11466 T11467 punct (,Table
R303 T2744 T2739 neg not,mimic
R3030 T11553 T11552 cc and,%
R3031 T11554 T11555 nummod 30.0,%
R3032 T11467 T11439 parataxis Table,appeared
R3033 T11555 T11552 conj %,%
R3034 T11556 T11533 punct ", ",increased
R3035 T11557 T11533 advmod respectively,increased
R3036 T11558 T11533 punct .,increased
R3037 T11560 T11561 prep In,were
R3038 T11562 T11560 pobj females,In
R3039 T11563 T11564 det these,increases
R304 T2745 T2746 det the,complexity
R3040 T11468 T11467 nummod 1,Table
R3041 T11564 T11561 nsubj increases,were
R3042 T11565 T11566 advmod much,larger
R3043 T11566 T11561 acomp larger,were
R3044 T11469 T11467 punct ),Table
R3045 T11567 T11561 punct .,were
R3046 T11569 T11570 det The,measurements
R3047 T11570 T11572 nsubjpass measurements,increased
R3048 T11571 T11570 amod same,measurements
R3049 T11573 T11572 auxpass were,increased
R305 T2746 T2739 dobj complexity,mimic
R3050 T11470 T11439 punct .,appeared
R3051 T11574 T11572 prep by,increased
R3052 T11575 T11576 nummod 68.8,%
R3053 T11576 T11574 pobj %,by
R3054 T11577 T11576 punct ", ",%
R3055 T11578 T11579 nummod 99.4,%
R3056 T11472 T11473 prep In,was
R3057 T11579 T11576 conj %,%
R3058 T11580 T11579 punct ", ",%
R3059 T11581 T11582 nummod 69.7,%
R306 T2747 T2746 amod genetic,complexity
R3060 T11582 T11579 conj %,%
R3061 T11583 T11582 cc and,%
R3062 T11473 T11482 ccomp was,were
R3063 T11584 T11585 nummod 57.3,%
R3064 T11585 T11582 conj %,%
R3065 T11474 T11472 pobj support,In
R3066 T11586 T11572 punct ", ",increased
R3067 T11587 T11572 advcl relative,increased
R3068 T11588 T11587 prep to,relative
R3069 T11475 T11474 prep of,support
R307 T2748 T2746 prep of,complexity
R3070 T11589 T11590 compound HGC,females
R3071 T11590 T11588 pobj females,to
R3072 T11476 T11475 pobj this,of
R3073 T11591 T11572 punct .,increased
R3074 T11477 T11473 punct ", ",was
R3075 T11593 T11594 det A,reduction
R3076 T11594 T11600 nsubjpass reduction,detected
R3077 T11595 T11596 nummod 2.9,%
R3078 T11596 T11594 nmod %,reduction
R3079 T11597 T11596 cc and,%
R308 T2749 T2750 compound disease,traits
R3080 T11598 T11599 nummod 3.6,%
R3081 T11478 T11479 det the,increase
R3082 T11599 T11596 conj %,%
R3083 T11601 T11594 prep in,reduction
R3084 T11602 T11603 amod male,NA
R3085 T11479 T11473 nsubj increase,was
R3086 T11603 T11601 pobj NA,in
R3087 T11604 T11602 cc and,male
R3088 T11605 T11602 conj female,male
R3089 T11606 T11600 punct ", ",detected
R309 T2750 T2748 pobj traits,of
R3090 T11607 T11600 advmod respectively,detected
R3091 T11608 T11600 punct ", ",detected
R3092 T11609 T11600 auxpass was,detected
R3093 T11480 T11479 prep in,increase
R3094 T11610 T11600 advmod also,detected
R3095 T11611 T11600 punct .,detected
R3096 T11481 T11480 pobj fat,in
R3097 T11613 T11614 nsubjpass This,expected
R3098 T11483 T11473 acomp dependent,was
R3099 T11615 T11614 auxpass was,expected
R310 T2751 T2752 advmod commonly,seen
R3100 T11616 T11617 mark since,found
R3101 T11484 T11483 prep on,dependent
R3102 T11485 T11484 pobj hg,on
R3103 T11617 T11614 advcl found,expected
R3104 T11618 T11617 nsubjpass NA,found
R3105 T11486 T11482 punct ;,were
R3106 T11619 T11617 auxpass was,found
R3107 T11620 T11617 advmod previously,found
R3108 T11487 T11482 advmod however,were
R3109 T11621 T11622 aux to,be
R311 T2752 T2750 acl seen,traits
R3110 T11622 T11617 xcomp be,found
R3111 T11623 T11624 det an,indicator
R3112 T11488 T11482 punct ", ",were
R3113 T11624 T11622 attr indicator,be
R3114 T11625 T11624 amod excellent,indicator
R3115 T11489 T11482 nsubj differences,were
R3116 T11626 T11624 prep of,indicator
R3117 T11627 T11628 compound femur,length
R3118 T11628 T11626 pobj length,of
R3119 T11490 T11489 prep in,differences
R312 T2753 T2752 prep in,seen
R3120 T11629 T11630 punct (,0.88
R3121 T11491 T11492 compound femur,length
R3122 T11630 T11622 parataxis 0.88,be
R3123 T11631 T11630 nsubj R2,0.88
R3124 T11632 T11630 punct =,0.88
R3125 T11492 T11490 pobj length,in
R3126 T11633 T11630 punct ),0.88
R3127 T11634 T11622 prep in,be
R3128 T11493 T11482 neg not,were
R3129 T11635 T11636 compound HG,mice
R313 T2754 T2755 det the,population
R3130 T11636 T11634 pobj mice,in
R3131 T11494 T11495 punct [,24
R3132 T11637 T11638 punct [,27
R3133 T11638 T11617 parataxis 27,found
R3134 T11639 T11638 punct ],27
R3135 T11495 T11482 parataxis 24,were
R3136 T11640 T11617 cc and,found
R3137 T11496 T11495 punct ],24
R3138 T11497 T11482 punct .,were
R3139 T11641 T11642 mark as,noted
R314 T2755 T2753 pobj population,in
R3140 T11642 T11643 advcl noted,contains
R3141 T11643 T11617 conj contains,found
R3142 T11644 T11642 advmod above,noted
R3143 T11499 T11500 prep In,increased
R3144 T11645 T11646 det this,region
R3145 T11646 T11643 nsubj region,contains
R3146 T11647 T11648 det the,QTL
R3147 T11648 T11643 dobj QTL,contains
R3148 T11501 T11499 pobj confirmation,In
R3149 T11649 T11648 compound Feml2,QTL
R315 T2756 T2755 amod human,population
R3150 T11650 T11651 punct [,24
R3151 T11502 T11501 prep of,confirmation
R3152 T11651 T11643 parataxis 24,contains
R3153 T11652 T11651 punct ],24
R3154 T11653 T11614 punct .,expected
R3155 T11503 T11502 pobj Carfhg2,of
R3156 T11504 T11505 det all,measures
R3157 T11655 T11656 det These,data
R3158 T11656 T11657 nsubj data,confirm
R3159 T11505 T11500 nsubjpass measures,increased
R316 T2757 T2739 punct .,mimic
R3160 T11658 T11659 det the,effects
R3161 T11659 T11657 dobj effects,confirm
R3162 T11660 T11659 prep of,effects
R3163 T11506 T11505 prep of,measures
R3164 T11661 T11660 pobj Carfhg2,of
R3165 T11662 T11659 prep on,effects
R3166 T11507 T11506 pobj adiposity,of
R3167 T11663 T11662 pobj adiposity,on
R3168 T11664 T11659 cc and,effects
R3169 T11665 T11659 conj Feml2,effects
R317 T2759 T2760 compound Complex,traits
R3170 T11508 T11507 prep in,adiposity
R3171 T11666 T11665 prep on,Feml2
R3172 T11667 T11666 pobj length,on
R3173 T11509 T11510 compound HG9,mice
R3174 T11668 T11657 cc and,confirm
R3175 T11669 T11657 conj indicate,confirm
R3176 T11670 T11671 det the,effects
R3177 T11510 T11508 pobj mice,in
R3178 T11671 T11673 nsubj effects,are
R3179 T11672 T11671 amod isolated,effects
R318 T2760 T2761 nsubjpass traits,influenced
R3180 T11673 T11669 advcl are,indicate
R3181 T11511 T11500 auxpass were,increased
R3182 T11674 T11671 prep of,effects
R3183 T11675 T11674 pobj Carfhg2,of
R3184 T11512 T11500 advcl relative,increased
R3185 T11676 T11677 advmod more,significant
R3186 T11677 T11673 acomp significant,are
R3187 T11678 T11679 mark than,observed
R3188 T11513 T11512 prep to,relative
R3189 T11679 T11677 advcl observed,significant
R319 T2762 T2760 punct ", ",traits
R3190 T11680 T11679 advmod originally,observed
R3191 T11681 T11657 punct .,confirm
R3192 T11514 T11515 compound control,mice
R3193 T11685 T11686 prep In,linked
R3194 T11687 T11688 det the,intercross
R3195 T11515 T11513 pobj mice,to
R3196 T11688 T11685 pobj intercross,In
R3197 T11689 T11688 amod original,intercross
R3198 T11516 T11500 punct ;,increased
R3199 T11690 T11691 compound CAST,alleles
R320 T2763 T2764 amod such,as
R3200 T11691 T11686 nsubjpass alleles,linked
R3201 T11692 T11691 prep near,alleles
R3202 T11517 T11500 prep except,increased
R3203 T11693 T11694 nummod 50,cM
R3204 T11694 T11692 pobj cM,near
R3205 T11518 T11517 pobj MFP,except
R3206 T11695 T11691 prep on,alleles
R3207 T11696 T11695 pobj MMU11,on
R3208 T11519 T11518 prep in,MFP
R3209 T11697 T11686 auxpass were,linked
R321 T2764 T2760 prep as,traits
R3210 T11698 T11686 prep with,linked
R3211 T11699 T11700 det a,reduction
R3212 T11520 T11521 preconj both,sexes
R3213 T11700 T11698 pobj reduction,with
R3214 T11701 T11700 prep in,reduction
R3215 T11702 T11701 pobj G29,in
R3216 T11521 T11519 pobj sexes,in
R3217 T11703 T11702 punct ", ",G29
R3218 T11704 T11705 compound carcass,ash
R3219 T11522 T11518 cc and,MFP
R322 T2765 T2766 amod polygenic,growth
R3220 T11705 T11702 conj ash,G29
R3221 T11706 T11705 punct (,ash
R3222 T11523 T11518 conj BMI,MFP
R3223 T11707 T11705 appos ASH,ash
R3224 T11524 T11523 prep in,BMI
R3225 T11708 T11705 punct ),ash
R3226 T11709 T11705 cc and,ash
R3227 T11710 T11711 compound carcass,protein
R3228 T11525 T11524 pobj males,in
R3229 T11711 T11705 conj protein,ash
R323 T2766 T2764 pobj growth,as
R3230 T11712 T11711 punct (,protein
R3231 T11526 T11527 punct (,Table
R3232 T11713 T11711 appos PROT,protein
R3233 T11714 T11686 punct ),linked
R3234 T11715 T11716 punct [,24
R3235 T11527 T11500 parataxis Table,increased
R3236 T11716 T11686 parataxis 24,linked
R3237 T11717 T11716 punct ],24
R3238 T11528 T11527 nummod 5,Table
R3239 T11718 T11686 punct .,linked
R324 T2767 T2766 cc and,growth
R3240 T11529 T11527 punct ),Table
R3241 T11720 T11721 advmod Therefore,measured
R3242 T11722 T11721 punct ", ",measured
R3243 T11723 T11721 nsubj we,measured
R3244 T11724 T11725 det each,component
R3245 T11725 T11721 dobj component,measured
R3246 T11726 T11725 compound carcass,component
R3247 T11530 T11500 punct .,increased
R3248 T11727 T11721 advcl using,measured
R3249 T11728 T11729 amod chemical,analysis
R325 T2768 T2766 conj obesity,growth
R3250 T11729 T11727 dobj analysis,using
R3251 T11532 T11533 prep In,increased
R3252 T11730 T11729 amod compositional,analysis
R3253 T11731 T11727 prep in,using
R3254 T11732 T11733 det the,strains
R3255 T11733 T11731 pobj strains,in
R3256 T11534 T11532 pobj males,In
R3257 T11734 T11733 nmod HGC,strains
R3258 T11735 T11734 punct ", ",HGC
R3259 T11736 T11734 conj HG11,HGC
R326 T2769 T2761 auxpass are,influenced
R3260 T11737 T11736 cc and,HG11
R3261 T11747 T11748 det the,presence
R3262 T11738 T11736 conj HG17,HG11
R3263 T11739 T11721 punct .,measured
R3264 T11748 T11746 pobj presence,on
R3265 T11741 T11742 advmod Originally,was
R3266 T11749 T11748 prep of,presence
R3267 T11743 T11742 punct ", ",was
R3268 T11744 T11742 nsubj Carp2,was
R3269 T11745 T11742 acomp dependent,was
R327 T2770 T2761 agent by,influenced
R3270 T11750 T11749 pobj hg,of
R3271 T11746 T11745 prep on,dependent
R3272 T11751 T11742 cc and,was
R3273 T11752 T11753 det no,effects
R3274 T11753 T11756 nsubjpass effects,detected
R3275 T11754 T11753 amod significant,effects
R3276 T11853 T11847 conj increase,increase
R3277 T11755 T11753 compound sex,effects
R3278 T11854 T11853 amod small,increase
R3279 T11855 T11853 amod suggestive,increase
R328 T2771 T2772 det the,effects
R3280 T11856 T11853 prep in,increase
R3281 T11756 T11742 conj detected,was
R3282 T11857 T11856 pobj NA,in
R3283 T11858 T11859 punct (,0.06
R3284 T11757 T11756 auxpass were,detected
R3285 T11859 T11840 parataxis 0.06,displayed
R3286 T11860 T11859 nsubj P,0.06
R3287 T11861 T11859 punct =,0.06
R3288 T11758 T11759 punct [,24
R3289 T11862 T11859 punct ),0.06
R329 T2772 T2770 pobj effects,by
R3290 T11863 T11840 punct ", ",displayed
R3291 T11864 T11865 mark while,displayed
R3292 T11759 T11742 parataxis 24,was
R3293 T11865 T11840 advcl displayed,displayed
R3294 T11866 T11865 nsubj females,displayed
R3295 T11867 T11868 amod significant,decreases
R3296 T11868 T11865 dobj decreases,displayed
R3297 T11869 T11868 prep in,decreases
R3298 T11870 T11869 pobj NA,in
R3299 T11871 T11840 punct .,displayed
R330 T2773 T2772 amod small,effects
R3300 T11760 T11759 punct ],24
R3301 T11873 T11874 prep In,seen
R3302 T11761 T11742 punct .,was
R3303 T11875 T11873 pobj support,In
R3304 T11876 T11875 prep of,support
R3305 T11877 T11878 det the,QTL
R3306 T11763 T11764 prep In,displayed
R3307 T11878 T11876 pobj QTL,of
R3308 T11879 T11880 npadvmod sex,specific
R3309 T11765 T11763 pobj contrast,In
R331 T2774 T2773 prep to,small
R3310 T11880 T11878 amod specific,QTL
R3311 T11881 T11880 punct -,specific
R3312 T11882 T11883 nmod effects,strain
R3313 T11883 T11884 nmod strain,interactions
R3314 T11766 T11765 prep to,contrast
R3315 T11884 T11874 nsubjpass interactions,seen
R3316 T11885 T11883 prep by,strain
R3317 T11886 T11885 pobj sex,by
R3318 T11767 T11768 det those,results
R3319 T11887 T11888 punct (,0.04
R332 T2775 T2774 amod moderate,to
R3320 T11888 T11884 parataxis 0.04,interactions
R3321 T11768 T11766 pobj results,to
R3322 T11889 T11888 nsubj P,0.04
R3323 T11890 T11888 punct <,0.04
R3324 T11891 T11888 punct ),0.04
R3325 T11769 T11764 punct ", ",displayed
R3326 T11892 T11874 auxpass were,seen
R3327 T11893 T11874 prep for,seen
R3328 T11894 T11895 det the,traits
R3329 T11770 T11771 compound HG11,mice
R333 T2776 T2772 amod direct,effects
R3330 T11895 T11893 pobj traits,for
R3331 T11896 T11895 amod following,traits
R3332 T11897 T11895 compound growth,traits
R3333 T11771 T11764 nsubj mice,displayed
R3334 T11898 T11895 punct : ,traits
R3335 T11899 T11895 appos 3WK,traits
R3336 T11900 T11899 punct ", ",3WK
R3337 T11772 T11773 amod significant,differences
R3338 T11901 T11899 conj 6WK,3WK
R3339 T11902 T11901 punct ", ",6WK
R334 T2777 T2772 prep of,effects
R3340 T11903 T11901 conj 9WK,6WK
R3341 T11773 T11764 dobj differences,displayed
R3342 T11904 T11903 punct ", ",9WK
R3343 T11905 T11903 conj G26,9WK
R3344 T11906 T11905 punct ", ",G26
R3345 T11774 T11773 prep in,differences
R3346 T11907 T11905 conj G29,G26
R3347 T11908 T11907 cc and,G29
R3348 T11909 T11907 conj NA,G29
R3349 T11910 T11911 punct (,shown
R335 T2778 T2779 amod quantitative,loci
R3350 T11911 T11874 parataxis shown,seen
R3351 T11912 T11911 nsubj data,shown
R3352 T11913 T11911 neg not,shown
R3353 T11775 T11774 pobj growth,in
R3354 T11914 T11911 punct ),shown
R3355 T11915 T11874 punct .,seen
R3356 T11776 T11775 cc and,growth
R3357 T11917 T11918 det The,basis
R3358 T11918 T11919 nsubj basis,was
R3359 T11777 T11775 conj obesity,growth
R336 T2779 T2777 pobj loci,of
R3360 T11920 T11918 prep of,basis
R3361 T11921 T11922 det each,interaction
R3362 T11778 T11764 prep between,displayed
R3363 T11922 T11920 pobj interaction,of
R3364 T11923 T11924 det an,increase
R3365 T11779 T11780 det the,sexes
R3366 T11924 T11919 attr increase,was
R3367 T11925 T11924 prep in,increase
R3368 T11926 T11927 det the,males
R3369 T11780 T11778 pobj sexes,between
R337 T2780 T2779 compound trait,loci
R3370 T11927 T11925 pobj males,in
R3371 T11781 T11764 punct .,displayed
R3372 T11928 T11924 cc and,increase
R3373 T11929 T11930 det a,decrease
R3374 T11930 T11924 conj decrease,increase
R3375 T11931 T11930 prep in,decrease
R3376 T11783 T11784 prep In,demonstrated
R3377 T11932 T11931 pobj females,in
R3378 T11933 T11919 punct .,was
R3379 T11935 T11936 prep In,observed
R338 T2781 T2779 punct (,loci
R3380 T11785 T11783 amod general,In
R3381 T11937 T11938 poss our,analysis
R3382 T11938 T11935 pobj analysis,In
R3383 T11939 T11938 prep of,analysis
R3384 T11786 T11784 punct ", ",demonstrated
R3385 T11940 T11941 det the,strains
R3386 T11941 T11939 pobj strains,of
R3387 T11942 T11941 nmod HGC,strains
R3388 T11787 T11784 nsubj males,demonstrated
R3389 T11943 T11942 punct ", ",HGC
R339 T2782 T2779 appos QTL,loci
R3390 T11944 T11942 conj HG11,HGC
R3391 T11788 T11789 det a,increase
R3392 T11945 T11944 cc and,HG11
R3393 T11946 T11944 conj HG17,HG11
R3394 T11947 T11936 punct ", ",observed
R3395 T11789 T11784 dobj increase,demonstrated
R3396 T11948 T11949 amod concordant,results
R3397 T11949 T11936 nsubjpass results,observed
R3398 T11950 T11936 auxpass were,observed
R3399 T11951 T11936 advcl measuring,observed
R340 T2783 T2779 punct ),loci
R3400 T11952 T11951 dobj adiposity,measuring
R3401 T11953 T11951 advcl using,measuring
R3402 T11954 T11955 amod chemical,extraction
R3403 T11955 T11953 dobj extraction,using
R3404 T11956 T11955 compound lipid,extraction
R3405 T11790 T11791 nummod 5,%
R3406 T11957 T11953 cc and,using
R3407 T11958 T11953 conj weighing,using
R3408 T11791 T11789 compound %,increase
R3409 T11792 T11784 cc and,demonstrated
R341 T2784 T2779 punct ", ",loci
R3410 T11959 T11960 compound fat,pad
R3411 T11960 T11961 compound pad,mass
R3412 T11793 T11794 nsubj females,decrease
R3413 T11961 T11958 dobj mass,weighing
R3414 T11962 T11936 punct .,observed
R3415 T11794 T11784 conj decrease,demonstrated
R3416 T11964 T11965 det The,correlation
R3417 T11795 T11794 det a,decrease
R3418 T11965 T11967 nsubj correlation,was
R3419 T11796 T11797 nummod 5,%
R342 T2785 T2779 conj epistasis,loci
R3420 T11966 T11965 amod phenotypic,correlation
R3421 T11797 T11794 compound %,decrease
R3422 T11968 T11965 prep between,correlation
R3423 T11969 T11970 compound carcass,fat
R3424 T11798 T11794 prep in,decrease
R3425 T11970 T11968 pobj fat,between
R3426 T11971 T11970 punct (,fat
R3427 T11799 T11800 det all,traits
R3428 T11972 T11970 appos FAT,fat
R3429 T11973 T11965 punct ),correlation
R343 T2786 T2785 prep between,epistasis
R3430 T11800 T11798 pobj traits,in
R3431 T11974 T11965 prep as,correlation
R3432 T11975 T11976 det a,percent
R3433 T11801 T11802 npadvmod growth,related
R3434 T11976 T11974 pobj percent,as
R3435 T11977 T11976 prep of,percent
R3436 T11978 T11979 det the,weight
R3437 T11802 T11800 amod related,traits
R3438 T11979 T11977 pobj weight,of
R3439 T11980 T11979 amod empty,weight
R344 T2787 T2788 compound QTL,alleles
R3440 T11803 T11802 punct -,related
R3441 T11981 T11979 compound carcass,weight
R3442 T11982 T11979 punct (,weight
R3443 T11983 T11979 appos ECW,weight
R3444 T11804 T11805 punct (,Table
R3445 T11984 T11983 punct ;,ECW
R3446 T11985 T11983 appos weight,ECW
R3447 T11986 T11985 prep of,weight
R3448 T11805 T11784 parataxis Table,demonstrated
R3449 T11987 T11988 amod total,body
R345 T2788 T2786 pobj alleles,between
R3450 T11988 T11986 pobj body,of
R3451 T11989 T11985 punct (,weight
R3452 T11990 T11985 prep including,weight
R3453 T11991 T11990 pobj organs,including
R3454 T11992 T11985 punct ),weight
R3455 T11993 T11985 cc minus,weight
R3456 T11806 T11805 nummod 4,Table
R3457 T11994 T11995 det the,head
R3458 T11995 T11985 conj head,weight
R3459 T11996 T11995 cc and,head
R346 T2789 T2785 punct ", ",epistasis
R3460 T11807 T11805 punct ),Table
R3461 T11997 T11998 amod gastrointestinal,tract
R3462 T11998 T11995 conj tract,head
R3463 T11999 T11985 punct ),weight
R3464 T11808 T11784 punct .,demonstrated
R3465 T12000 T11965 punct (,correlation
R3466 T12001 T12002 compound %,FAT
R3467 T12002 T11965 appos FAT,correlation
R3468 T11810 T11811 nsubj Most,were
R3469 T12003 T11965 punct ),correlation
R347 T2790 T2791 amod environmental,perturbations
R3470 T12004 T11965 acl determined,correlation
R3471 T12005 T12004 prep by,determined
R3472 T11812 T11810 prep of,Most
R3473 T12006 T12007 amod chemical,analysis
R3474 T12007 T12005 pobj analysis,by
R3475 T12008 T12007 cc and,analysis
R3476 T12009 T12007 conj AI,analysis
R3477 T11813 T11814 det these,differences
R3478 T12010 T12004 punct ", ",determined
R3479 T11814 T11812 pobj differences,of
R348 T2791 T2785 conj perturbations,epistasis
R3480 T12011 T12004 advcl using,determined
R3481 T12012 T12011 dobj data,using
R3482 T12013 T12012 prep from,data
R3483 T12014 T12015 det all,lines
R3484 T11815 T11811 punct ", ",were
R3485 T12015 T12013 pobj lines,from
R3486 T12016 T12015 nummod three,lines
R3487 T12017 T12015 punct (,lines
R3488 T11816 T11811 advmod however,were
R3489 T12018 T12015 appos HGC,lines
R349 T2792 T2791 cc and,perturbations
R3490 T12019 T12018 punct ", ",HGC
R3491 T12020 T12018 conj HG11,HGC
R3492 T11817 T11811 punct ", ",were
R3493 T12021 T12020 cc and,HG11
R3494 T12022 T12020 conj HG17,HG11
R3495 T11818 T11811 neg not,were
R3496 T12023 T11967 punct ),was
R3497 T12024 T11967 punct ", ",was
R3498 T12025 T11967 attr 0.92,was
R3499 T11819 T11811 acomp significant,were
R350 T2793 T2794 compound QTL,environment
R3500 T12026 T11967 punct .,was
R3501 T11820 T11811 prep at,were
R3502 T12028 T12029 det These,data
R3503 T12029 T12030 nsubj data,suggest
R3504 T12031 T12032 mark that,is
R3505 T12032 T12030 ccomp is,suggest
R3506 T12033 T12034 amod individual,dissection
R3507 T11821 T11822 det a,0.005
R3508 T12034 T12032 nsubj dissection,is
R3509 T12035 T12036 compound fat,pad
R351 T2794 T2796 compound environment,interactions
R3510 T12036 T12034 compound pad,dissection
R3511 T12037 T12038 det an,proxy
R3512 T11822 T11820 pobj 0.005,at
R3513 T12038 T12032 attr proxy,is
R3514 T12039 T12038 amod excellent,proxy
R3515 T11823 T11822 amod critical,0.005
R3516 T12040 T12038 prep for,proxy
R3517 T12041 T12040 pcomp measuring,for
R3518 T12042 T12043 amod whole,body
R3519 T11824 T11822 nsubj P,0.005
R352 T2795 T2794 punct -,environment
R3520 T12043 T12044 compound body,adiposity
R3521 T12044 T12041 dobj adiposity,measuring
R3522 T12045 T12032 cc and,is
R3523 T11825 T11822 punct <,0.005
R3524 T12046 T12032 conj provides,is
R3525 T12047 T12048 det a,technique
R3526 T11826 T11811 punct ", ",were
R3527 T12048 T12046 dobj technique,provides
R3528 T11827 T11828 mark although,were
R3529 T12049 T12050 advmod much,more
R353 T2796 T2791 conj interactions,perturbations
R3530 T12050 T12051 advmod more,sensitive
R3531 T11828 T11811 advcl were,were
R3532 T12051 T12048 amod sensitive,technique
R3533 T11829 T11830 advmod almost,all
R3534 T12052 T12053 aux to,measure
R3535 T12053 T12048 advcl measure,technique
R3536 T12054 T12055 compound fat,accumulation
R3537 T11830 T11828 nsubj all,were
R3538 T12055 T12053 dobj accumulation,measure
R3539 T12056 T12053 prep in,measure
R354 T2797 T2761 punct .,influenced
R3540 T12057 T12058 amod specific,regions
R3541 T11831 T11828 prep at,were
R3542 T12058 T12056 pobj regions,in
R3543 T12059 T12058 compound body,regions
R3544 T11832 T11833 det a,0.05
R3545 T12060 T12030 punct .,suggest
R3546 T11833 T11831 pobj 0.05,at
R3547 T12062 T12063 compound HG11,females
R3548 T12063 T12064 nsubj females,displayed
R3549 T11834 T11833 amod nominal,0.05
R355 T2799 T2800 prep To,localized
R3550 T11835 T11833 nsubj P,0.05
R3551 T11836 T11833 punct <,0.05
R3552 T12065 T12066 amod slight,increases
R3553 T11837 T11811 punct .,were
R3554 T12066 T12064 dobj increases,displayed
R3555 T12067 T12066 prep in,increases
R3556 T12068 T12069 det all,pads
R3557 T12069 T12067 pobj pads,in
R3558 T12070 T12069 compound fat,pads
R3559 T12071 T12069 punct (,pads
R356 T2800 T2810 ccomp localized,made
R3560 T12072 T12069 prep except,pads
R3561 T11839 T11840 advcl Following,displayed
R3562 T12073 T12072 pobj MFP,except
R3563 T12074 T12069 punct ),pads
R3564 T12075 T12069 cc and,pads
R3565 T12076 T12069 conj AI,pads
R3566 T11841 T11842 det the,trend
R3567 T12077 T12064 punct ", ",displayed
R3568 T12078 T12079 mark although,was
R3569 T12079 T12064 advcl was,displayed
R357 T2801 T2799 pobj date,To
R3570 T12080 T12079 punct ", ",was
R3571 T12081 T12082 advmod only,increase
R3572 T11842 T11839 dobj trend,Following
R3573 T12082 T12079 nsubj increase,was
R3574 T12083 T12082 det the,increase
R3575 T12084 T12085 nummod 16.5,%
R3576 T12085 T12082 compound %,increase
R3577 T11843 T11842 amod same,trend
R3578 T12086 T12082 prep in,increase
R3579 T12087 T12086 pobj AI,in
R358 T2802 T2803 amod numerous,QTL
R3580 T12088 T12079 acomp significant,was
R3581 T11844 T11840 punct ", ",displayed
R3582 T12089 T12090 punct (,Table
R3583 T12090 T12079 parataxis Table,was
R3584 T12091 T12090 nummod 5,Table
R3585 T12092 T12090 punct ),Table
R3586 T11845 T11840 nsubj males,displayed
R3587 T12093 T12064 punct .,displayed
R3588 T11846 T11847 det an,increase
R3589 T12095 T12096 prep In,show
R359 T2803 T2800 nsubjpass QTL,localized
R3590 T12097 T12095 pobj contrast,In
R3591 T12098 T12096 punct ", ",show
R3592 T12099 T12100 compound HG11,males
R3593 T11847 T11840 dobj increase,displayed
R3594 T12100 T12096 nsubj males,show
R3595 T12101 T12096 aux did,show
R3596 T12102 T12096 neg not,show
R3597 T11848 T11847 prep in,increase
R3598 T12103 T12104 det a,difference
R3599 T12104 T12096 dobj difference,show
R360 T2804 T2805 nmod mouse,growth
R3600 T12105 T12104 prep in,difference
R3601 T11849 T11850 compound tail,length
R3602 T12106 T12107 compound fat,mass
R3603 T12107 T12105 pobj mass,in
R3604 T12108 T12104 acl leading,difference
R3605 T11850 T11848 pobj length,in
R3606 T12109 T12108 prep to,leading
R3607 T12110 T12111 det a,interaction
R3608 T12111 T12109 pobj interaction,to
R3609 T12112 T12111 amod significant,interaction
R361 T2805 T2803 nmod growth,QTL
R3610 T12113 T12111 nmod strain,interaction
R3611 T12114 T12113 prep by,strain
R3612 T12115 T12114 pobj sex,by
R3613 T12116 T12117 punct (,0.008
R3614 T12117 T12111 parataxis 0.008,interaction
R3615 T11851 T11847 cc and,increase
R3616 T12118 T12117 nsubj P,0.008
R3617 T12119 T12117 punct =,0.008
R3618 T12120 T12117 punct ),0.008
R3619 T11852 T11853 det a,increase
R362 T2806 T2805 cc and,growth
R3620 T12121 T12111 prep for,interaction
R3621 T12122 T12121 pobj AI,for
R3622 T12123 T12124 punct (,shown
R3623 T12124 T12108 parataxis shown,leading
R3624 T12125 T12124 nsubj data,shown
R3625 T12170 T12169 pobj ECW,of
R3626 T12126 T12124 neg not,shown
R3627 T12127 T12124 punct ),shown
R3628 T12128 T12096 punct .,show
R3629 T12130 T12131 advcl Identical,displayed
R363 T2807 T2805 conj obesity,growth
R3630 T12132 T12130 prep to,Identical
R3631 T12171 T12168 punct (,percent
R3632 T12133 T12134 det the,results
R3633 T12134 T12132 pobj results,to
R3634 T12172 T12173 compound %,ASH
R3635 T12135 T12134 acl obtained,results
R3636 T12173 T12168 appos ASH,percent
R3637 T12136 T12135 advcl using,obtained
R3638 T12174 T12158 punct ),had
R3639 T12137 T12138 compound fat,pad
R364 T2808 T2800 aux have,localized
R3640 T12138 T12139 compound pad,weights
R3641 T12139 T12136 dobj weights,using
R3642 T12175 T12158 cc and,had
R3643 T12140 T12131 punct ;,displayed
R3644 T12141 T12142 amod female,carcasses
R3645 T12142 T12131 nsubj carcasses,displayed
R3646 T12176 T12177 amod female,carcasses
R3647 T12143 T12142 compound HG11,carcasses
R3648 T12144 T12145 det an,increase
R3649 T12177 T12178 nsubj carcasses,displayed
R365 T2809 T2800 auxpass been,localized
R3650 T12145 T12131 dobj increase,displayed
R3651 T12146 T12145 prep in,increase
R3652 T12147 T12148 compound %,FAT
R3653 T12148 T12146 pobj FAT,in
R3654 T12149 T12150 punct (,Table
R3655 T12178 T12158 conj displayed,had
R3656 T12150 T12131 parataxis Table,displayed
R3657 T12151 T12150 nummod 6,Table
R3658 T12179 T12180 amod lower,levels
R3659 T12152 T12150 punct ),Table
R366 T2811 T2812 punct [,2
R3660 T12153 T12131 punct .,displayed
R3661 T12155 T12156 nmod HG11,carcasses
R3662 T12180 T12178 dobj levels,displayed
R3663 T12181 T12180 prep of,levels
R3664 T12156 T12158 nsubj carcasses,had
R3665 T12182 T12181 pobj H2O,of
R3666 T12157 T12156 amod male,carcasses
R3667 T12183 T12182 cc and,H2O
R3668 T12159 T12160 amod higher,levels
R3669 T12160 T12158 dobj levels,had
R367 T2812 T2800 parataxis 2,localized
R3670 T12161 T12162 compound carcass,ash
R3671 T12184 T12182 conj ASH,H2O
R3672 T12162 T12160 appos ash,levels
R3673 T12163 T12162 punct (,ash
R3674 T12164 T12162 appos ASH,ash
R3675 T12185 T12186 punct (,Table
R3676 T12165 T12160 punct ),levels
R3677 T12166 T12160 prep as,levels
R3678 T12186 T12178 parataxis Table,displayed
R3679 T12167 T12168 det a,percent
R368 T2813 T2812 nummod 1,2
R3680 T12168 T12166 pobj percent,as
R3681 T12169 T12168 prep of,percent
R3682 T12187 T12186 nummod 6,Table
R3683 T12188 T12186 punct ),Table
R3684 T12189 T12178 punct .,displayed
R3685 T12276 T12274 amod specific,QTL
R3686 T12191 T12192 nmod Strains,interactions
R3687 T12277 T12276 punct -,specific
R3688 T12278 T12274 prep with,QTL
R3689 T12279 T12280 amod opposing,action
R369 T2814 T2812 punct ",",2
R3690 T12280 T12278 pobj action,with
R3691 T12281 T12266 punct .,be
R3692 T12192 T12195 nsubjpass interactions,identified
R3693 T12193 T12191 prep by,Strains
R3694 T12194 T12193 pobj sex,by
R3695 T12285 T12286 prep In,associated
R3696 T12287 T12288 det the,intercross
R3697 T12196 T12197 punct (,0.005
R3698 T12288 T12285 pobj intercross,In
R3699 T12289 T12288 amod original,intercross
R370 T2815 T2812 punct ],2
R3700 T12197 T12192 parataxis 0.005,interactions
R3701 T12290 T12291 compound CAST,alleles
R3702 T12291 T12286 nsubjpass alleles,associated
R3703 T12292 T12291 prep at,alleles
R3704 T12198 T12197 nsubj P,0.005
R3705 T12293 T12294 compound MMU17,markers
R3706 T12294 T12292 pobj markers,at
R3707 T12295 T12286 auxpass were,associated
R3708 T12199 T12197 punct <,0.005
R3709 T12296 T12286 prep with,associated
R371 T2816 T2810 punct ", ",made
R3710 T12297 T12296 pobj decreases,with
R3711 T12298 T12297 prep in,decreases
R3712 T12299 T12300 compound femur,length
R3713 T12300 T12298 pobj length,in
R3714 T12301 T12300 punct ", ",length
R3715 T12302 T12300 conj ASH,length
R3716 T12303 T12302 cc and,ASH
R3717 T12200 T12197 punct ),0.005
R3718 T12304 T12302 conj PROT,ASH
R3719 T12305 T12306 punct [,24
R372 T2817 T2810 advmod however,made
R3720 T12201 T12195 auxpass were,identified
R3721 T12306 T12286 parataxis 24,associated
R3722 T12202 T12195 prep for,identified
R3723 T12307 T12306 punct ],24
R3724 T12203 T12202 pobj H2O,for
R3725 T12308 T12286 cc and,associated
R3726 T12309 T12310 amod similar,results
R3727 T12310 T12311 nsubjpass results,seen
R3728 T12204 T12203 punct ", ",H2O
R3729 T12311 T12286 conj seen,associated
R373 T2818 T2810 punct ", ",made
R3730 T12312 T12311 auxpass were,seen
R3731 T12313 T12311 prep in,seen
R3732 T12205 T12206 compound %,H2O
R3733 T12314 T12315 compound HG17,mice
R3734 T12315 T12313 pobj mice,in
R3735 T12206 T12203 conj H2O,H2O
R3736 T12316 T12286 punct .,associated
R3737 T12207 T12206 punct ", ",H2O
R3738 T12318 T12319 advmod Interestingly,were
R3739 T12320 T12319 punct ", ",were
R374 T2819 T2820 amod little,progress
R3740 T12208 T12209 compound %,FAT
R3741 T12321 T12322 det both,sexes
R3742 T12322 T12319 nsubj sexes,were
R3743 T12323 T12319 acomp heavier,were
R3744 T12209 T12206 conj FAT,H2O
R3745 T12324 T12323 prep at,heavier
R3746 T12325 T12324 pobj 2WK,at
R3747 T12326 T12327 punct (,0.0342
R3748 T12210 T12209 punct ", ",FAT
R3749 T12327 T12323 parataxis 0.0342,heavier
R375 T2820 T2810 nsubjpass progress,made
R3750 T12328 T12329 dep males,0.0045
R3751 T12211 T12209 conj ASH,FAT
R3752 T12329 T12327 dep 0.0045,0.0342
R3753 T12330 T12329 punct ", ",0.0045
R3754 T12212 T12211 cc and,ASH
R3755 T12331 T12329 nsubj P,0.0045
R3756 T12332 T12329 punct =,0.0045
R3757 T12333 T12327 punct ;,0.0342
R3758 T12213 T12211 conj PROT,ASH
R3759 T12334 T12327 dep females,0.0342
R376 T2821 T2810 aux has,made
R3760 T12335 T12327 punct ", ",0.0342
R3761 T12214 T12215 punct (,shown
R3762 T12336 T12327 nsubj P,0.0342
R3763 T12337 T12327 punct =,0.0342
R3764 T12338 T12327 punct ),0.0342
R3765 T12339 T12323 punct ", ",heavier
R3766 T12340 T12323 cc but,heavier
R3767 T12341 T12323 conj lighter,heavier
R3768 T12342 T12341 prep at,lighter
R3769 T12215 T12195 parataxis shown,identified
R377 T2822 T2810 auxpass been,made
R3770 T12343 T12342 pobj 9WK,at
R3771 T12344 T12319 punct ", ",were
R3772 T12345 T12319 advcl leading,were
R3773 T12216 T12215 nsubj data,shown
R3774 T12346 T12345 prep to,leading
R3775 T12347 T12348 advmod substantially,lower
R3776 T12348 T12349 amod lower,G26
R3777 T12217 T12215 neg not,shown
R3778 T12349 T12346 pobj G26,to
R3779 T12350 T12349 cc and,G26
R378 T2823 T2810 prep in,made
R3780 T12218 T12215 punct ),shown
R3781 T12351 T12349 conj G29,G26
R3782 T12352 T12353 punct (,Table
R3783 T12353 T12319 parataxis Table,were
R3784 T12219 T12195 punct .,identified
R3785 T12354 T12353 nummod 4,Table
R3786 T12355 T12353 punct ),Table
R3787 T12356 T12319 punct .,were
R3788 T12221 T12222 mark If,is
R3789 T12358 T12359 prep In,ranged
R379 T2824 T2823 pcomp determining,in
R3790 T12360 T12358 amod general,In
R3791 T12222 T12228 advcl is,be
R3792 T12361 T12362 compound growth,differences
R3793 T12362 T12359 nsubj differences,ranged
R3794 T12223 T12224 det the,phenotype
R3795 T12363 T12359 prep between,ranged
R3796 T12364 T12365 nummod 5,%
R3797 T12365 T12363 pobj %,between
R3798 T12224 T12222 nsubj phenotype,is
R3799 T12366 T12365 cc and,%
R380 T2825 T2826 det the,nature
R3800 T12367 T12368 nummod 15,%
R3801 T12368 T12365 conj %,%
R3802 T12225 T12224 amod aggregate,phenotype
R3803 T12369 T12365 amod lower,%
R3804 T12370 T12359 prep in,ranged
R3805 T12226 T12224 prep in,phenotype
R3806 T12371 T12372 amod congenic,mice
R3807 T12372 T12370 pobj mice,in
R3808 T12227 T12226 pobj HG11,in
R3809 T12373 T12359 punct .,ranged
R381 T2826 T2824 dobj nature,determining
R3810 T12375 T12376 det Both,sexes
R3811 T12229 T12222 prep due,is
R3812 T12376 T12377 nsubj sexes,had
R3813 T12378 T12379 amod significant,reductions
R3814 T12379 T12377 dobj reductions,had
R3815 T12380 T12379 prep in,reductions
R3816 T12381 T12382 compound length,traits
R3817 T12230 T12229 pcomp to,due
R3818 T12231 T12232 det a,locus
R3819 T12382 T12380 pobj traits,in
R382 T2827 T2826 amod specific,nature
R3820 T12232 T12229 pobj locus,due
R3821 T12383 T12377 advcl relative,had
R3822 T12384 T12383 prep to,relative
R3823 T12385 T12386 compound control,mice
R3824 T12233 T12232 amod single,locus
R3825 T12386 T12384 pobj mice,to
R3826 T12387 T12377 punct .,had
R3827 T12234 T12228 punct ", ",be
R3828 T12389 T12390 nsubjpass NA,reduced
R3829 T12235 T12236 poss its,function
R383 T2828 T2826 prep of,nature
R3830 T12391 T12390 auxpass was,reduced
R3831 T12392 T12390 prep by,reduced
R3832 T12393 T12394 nummod 2.7,%
R3833 T12236 T12228 nsubj function,be
R3834 T12394 T12392 pobj %,by
R3835 T12395 T12396 punct (,0.0186
R3836 T12237 T12228 aux may,be
R3837 T12238 T12239 aux to,disrupt
R3838 T12396 T12394 parataxis 0.0186,%
R3839 T12397 T12396 nsubj P,0.0186
R384 T2829 T2830 det the,variants
R3840 T12239 T12228 xcomp disrupt,be
R3841 T12398 T12396 punct =,0.0186
R3842 T12399 T12396 punct ),0.0186
R3843 T12400 T12394 cc and,%
R3844 T12240 T12241 compound energy,partitioning
R3845 T12401 T12402 nummod 3.4,%
R3846 T12402 T12394 conj %,%
R3847 T12403 T12390 prep in,reduced
R3848 T12241 T12239 dobj partitioning,disrupt
R3849 T12404 T12403 pobj males,in
R385 T2830 T2828 pobj variants,of
R3850 T12405 T12404 cc and,males
R3851 T12242 T12239 prep by,disrupt
R3852 T12406 T12404 conj females,males
R3853 T12407 T12390 punct ", ",reduced
R3854 T12243 T12242 pcomp decreasing,by
R3855 T12408 T12390 advmod respectively,reduced
R3856 T12409 T12410 punct (,Table
R3857 T12410 T12390 parataxis Table,reduced
R3858 T12244 T12245 det the,deposition
R3859 T12411 T12410 nummod 4,Table
R386 T2831 T2830 amod underlying,variants
R3860 T12412 T12410 punct ),Table
R3861 T12245 T12243 dobj deposition,decreasing
R3862 T12413 T12390 punct .,reduced
R3863 T12246 T12245 prep of,deposition
R3864 T12415 T12416 prep In,reduced
R3865 T12417 T12415 pobj addition,In
R3866 T12418 T12416 punct ", ",reduced
R3867 T12419 T12416 nsubjpass tail,reduced
R3868 T12420 T12416 auxpass was,reduced
R3869 T12421 T12416 prep by,reduced
R387 T2832 T2830 amod genetic,variants
R3870 T12247 T12248 amod lean,tissue
R3871 T12422 T12423 advmod approximately,6
R3872 T12423 T12424 nummod 6,%
R3873 T12424 T12421 pobj %,by
R3874 T12248 T12246 pobj tissue,of
R3875 T12425 T12416 prep in,reduced
R3876 T12426 T12427 det both,sexes
R3877 T12249 T12243 cc and,decreasing
R3878 T12427 T12425 pobj sexes,in
R3879 T12428 T12429 punct (,Table
R388 T2833 T2810 punct .,made
R3880 T12429 T12416 parataxis Table,reduced
R3881 T12250 T12243 conj increasing,decreasing
R3882 T12430 T12429 nummod 4,Table
R3883 T12431 T12429 punct ),Table
R3884 T12251 T12252 compound lipid,accumulation
R3885 T12432 T12416 punct .,reduced
R3886 T12252 T12250 dobj accumulation,increasing
R3887 T12434 T12435 prep In,displayed
R3888 T12436 T12434 amod general,In
R3889 T12253 T12252 prep in,accumulation
R389 T2835 T2836 nummod One,resource
R3890 T12437 T12435 punct ", ",displayed
R3891 T12438 T12439 compound HG17,mice
R3892 T12254 T12253 pobj females,in
R3893 T12439 T12435 nsubj mice,displayed
R3894 T12440 T12435 dobj increases,displayed
R3895 T12441 T12440 prep in,increases
R3896 T12255 T12243 punct ", ",decreasing
R3897 T12442 T12443 det all,pads
R3898 T12443 T12441 pobj pads,in
R3899 T12444 T12443 compound fat,pads
R390 T2836 T2837 nsubj resource,are
R3900 T12256 T12257 mark while,having
R3901 T12445 T12443 punct (,pads
R3902 T12446 T12443 prep except,pads
R3903 T12257 T12243 advcl having,decreasing
R3904 T12447 T12446 pobj MFP,except
R3905 T12448 T12443 punct ),pads
R3906 T12258 T12259 det the,action
R3907 T12449 T12443 punct ", ",pads
R3908 T12450 T12443 conj TF,pads
R3909 T12451 T12450 cc and,TF
R391 T2838 T2836 acl used,resource
R3910 T12259 T12257 dobj action,having
R3911 T12452 T12450 conj AI,TF
R3912 T12453 T12454 punct (,Table
R3913 T12260 T12259 amod opposite,action
R3914 T12454 T12435 parataxis Table,displayed
R3915 T12455 T12454 nummod 5,Table
R3916 T12456 T12454 punct ),Table
R3917 T12261 T12257 prep in,having
R3918 T12457 T12435 punct .,displayed
R3919 T12459 T12460 advmod However,were
R392 T2839 T2840 aux to,map
R3920 T12461 T12460 punct ", ",were
R3921 T12462 T12460 nsubj none,were
R3922 T12262 T12261 pobj males,in
R3923 T12463 T12462 prep of,none
R3924 T12464 T12465 det these,differences
R3925 T12465 T12463 pobj differences,of
R3926 T12263 T12228 punct .,be
R3927 T12466 T12460 acomp significant,were
R3928 T12467 T12460 prep at,were
R3929 T12265 T12266 advmod However,be
R393 T2840 T2838 advcl map,used
R3930 T12468 T12469 amod critical,0.005
R3931 T12469 T12467 pobj 0.005,at
R3932 T12470 T12469 nsubj P,0.005
R3933 T12471 T12469 punct <,0.005
R3934 T12267 T12266 punct ", ",be
R3935 T12472 T12460 punct .,were
R3936 T12474 T12475 prep In,possessed
R3937 T12268 T12266 nsubj it,be
R3938 T12476 T12474 pobj addition,In
R3939 T12477 T12475 punct ", ",possessed
R394 T2841 T2840 advmod fine,map
R3940 T12269 T12266 aux may,be
R3941 T12478 T12479 nmod HG17,carcasses
R3942 T12479 T12475 nsubj carcasses,possessed
R3943 T12480 T12479 amod male,carcasses
R3944 T12270 T12266 advmod also,be
R3945 T12481 T12482 amod lower,levels
R3946 T12482 T12475 dobj levels,possessed
R3947 T12483 T12482 prep of,levels
R3948 T12271 T12266 prep due,be
R3949 T12272 T12271 pcomp to,due
R395 T2842 T2840 dobj QTL,map
R3950 T12484 T12483 pobj H2O,of
R3951 T12485 T12484 cc and,H2O
R3952 T12486 T12484 conj ASH,H2O
R3953 T12273 T12274 amod distinct,QTL
R3954 T12274 T12271 pobj QTL,due
R3955 T12275 T12276 npadvmod sex,specific
R3956 T12487 T12475 punct ", ",possessed
R3957 T12488 T12489 mark while,contained
R3958 T12489 T12475 advcl contained,possessed
R3959 T12490 T12491 amod female,carcasses
R396 T2843 T2844 amod congenic,strains
R3960 T12491 T12489 nsubj carcasses,contained
R3961 T12492 T12493 amod lower,levels
R3962 T12493 T12489 dobj levels,contained
R3963 T12494 T12493 prep of,levels
R3964 T12495 T12496 compound %,H2O
R3965 T12496 T12494 pobj H2O,of
R3966 T12497 T12496 punct ", ",H2O
R3967 T12498 T12496 conj ASH,H2O
R3968 T12499 T12498 punct ", ",ASH
R3969 T12500 T12501 compound %,ASH
R397 T2844 T2837 attr strains,are
R3970 T12501 T12498 conj ASH,ASH
R3971 T12502 T12501 cc and,ASH
R3972 T12503 T12504 compound %,PROT
R3973 T12504 T12501 conj PROT,ASH
R3974 T12505 T12506 punct (,Table
R3975 T12506 T12475 parataxis Table,possessed
R3976 T12507 T12506 nummod 6,Table
R3977 T12508 T12506 punct ),Table
R3978 T12509 T12475 punct .,possessed
R398 T2903 T2904 amod congenic,analysis
R3987 T13271 T13272 nmod MMU,2
R3988 T13272 T13273 nummod 2,sequencing
R3989 T13274 T13272 punct ", ",2
R399 T2845 T2846 dep which,designed
R3990 T13275 T13272 conj 9,2
R3991 T13276 T13275 punct ", ",9
R3992 T13277 T13275 conj 11,9
R3993 T13278 T13277 cc and,11
R3994 T13279 T13277 conj 17,11
R3995 T13280 T13281 compound hg,modifier
R3996 T13281 T13273 compound modifier,sequencing
R3997 T13282 T13283 compound candidate,gene
R3998 T13283 T13273 compound gene,sequencing
R3999 T13285 T13286 det The,phenotype
R400 T2904 T2905 nsubj analysis,method
R4000 T13286 T13288 nsubj phenotype,is
R4001 T13287 T13286 compound HG,phenotype
R4002 T13288 T13289 ccomp is,reasoned
R4003 T13290 T13288 prep due,is
R4004 T13291 T13290 pcomp to,due
R4005 T13292 T13293 det the,deletion
R4006 T13293 T13290 pobj deletion,due
R4007 T13294 T13293 prep of,deletion
R4008 T13295 T13294 pobj Socs2,of
R4009 T13296 T13289 punct ", ",reasoned
R401 T2846 T2844 relcl designed,strains
R4010 T13297 T13289 advmod therefore,reasoned
R4011 T13298 T13289 nsubj we,reasoned
R4012 T13299 T13300 mark that,represent
R4013 T13300 T13289 ccomp represent,reasoned
R4014 T13301 T13300 nsubj QTL,represent
R4015 T13302 T13301 prep on,QTL
R4016 T13303 T13304 nmod MMU,2
R4017 T13304 T13302 pobj 2,on
R4018 T13305 T13304 punct ", ",2
R4019 T13306 T13304 conj 9,2
R402 T2905 T2899 ccomp method,considers
R4020 T13307 T13306 punct ", ",9
R4021 T13308 T13306 conj 11,9
R4022 T13309 T13308 cc and,11
R4023 T13310 T13308 conj 17,11
R4024 T13311 T13301 acl interacting,QTL
R4025 T13312 T13311 prep with,interacting
R4026 T13313 T13312 pobj hg,with
R4027 T13314 T13300 advmod possibly,represent
R4028 T13315 T13300 dobj variation,represent
R4029 T13316 T13315 prep within,variation
R403 T2906 T2905 det an,method
R4030 T13317 T13316 pobj genes,within
R4031 T13318 T13317 acl participating,genes
R4032 T13319 T13318 prep in,participating
R4033 T13320 T13321 amod various,aspects
R4034 T13321 T13319 pobj aspects,in
R4035 T13322 T13321 prep of,aspects
R4036 T13323 T13324 compound Gh,function
R4037 T13324 T13322 pobj function,of
R4038 T13325 T13289 punct .,reasoned
R4039 T13327 T13328 aux To,select
R404 T2847 T2846 auxpass are,designed
R4040 T13328 T13329 advcl select,identified
R4041 T13330 T13331 compound candidate,genes
R4042 T13331 T13328 dobj genes,select
R4043 T13332 T13331 prep for,genes
R4044 T13333 T13332 pobj sequencing,for
R4045 T13334 T13329 nsubj we,identified
R4046 T13335 T13329 dobj genes,identified
R4047 T13336 T13335 acl known,genes
R4048 T13337 T13338 aux to,be
R4049 T13338 T13336 xcomp be,known
R405 T2907 T2905 amod excellent,method
R4050 T13339 T13336 cc or,known
R4051 T13340 T13336 conj potentially,known
R4052 T13341 T13340 dep involved,potentially
R4053 T13342 T13341 prep in,involved
R4054 T13343 T13344 compound Gh,signaling
R4055 T13344 T13342 pobj signaling,in
R4056 T13345 T13336 punct ", ",known
R4057 T13346 T13336 conj are,known
R4058 T13347 T13346 acomp responsive,are
R4059 T13348 T13347 prep to,responsive
R406 T2908 T2909 aux to,confirm
R4060 T13349 T13348 pobj Gh,to
R4061 T13350 T13346 cc or,are
R4062 T13351 T13352 dep that,propagate
R4063 T13352 T13346 conj propagate,are
R4064 T13353 T13354 amod downstream,functions
R4065 T13354 T13352 dobj functions,propagate
R4066 T13355 T13354 compound Gh,functions
R4067 T13356 T13329 punct .,identified
R4068 T13358 T13359 compound Forty,four
R4069 T13359 T13361 nummod four,genes
R407 T2909 T2905 advcl confirm,method
R4070 T13360 T13359 punct -,four
R4071 T13361 T13365 nsubjpass genes,identified
R4072 T13362 T13363 compound hg,modifier
R4073 T13363 T13361 compound modifier,genes
R4074 T13364 T13361 compound candidate,genes
R4075 T13366 T13365 auxpass were,identified
R4076 T13367 T13365 prep from,identified
R4077 T13368 T13369 amod primary,literature
R4078 T13369 T13367 pobj literature,from
R4079 T13370 T13369 punct ", ",literature
R408 T2848 T2849 aux to,convert
R4080 T13371 T13369 conj reviews,literature
R4081 T13372 T13371 cc and,reviews
R4082 T13373 T13374 compound book,chapters
R4083 T13374 T13371 conj chapters,reviews
R4084 T13375 T13365 cc and,identified
R4085 T13376 T13365 conj coordinated,identified
R4086 T13377 T13376 advcl using,coordinated
R4087 T13378 T13379 det the,software
R4088 T13379 T13377 dobj software,using
R4089 T13380 T13379 nmod GenMAPP,software
R409 T2910 T2909 cc and,confirm
R4090 T13381 T13380 punct (,GenMAPP
R4091 T13382 T13383 compound Gene,MicroArray
R4092 T13383 T13384 compound MicroArray,Profiler
R4093 T13384 T13380 appos Profiler,GenMAPP
R4094 T13385 T13384 compound Pathway,Profiler
R4095 T13386 T13379 punct ),software
R4096 T13387 T13388 compound pathway,building
R4097 T13388 T13379 compound building,software
R4098 T13389 T13390 punct (,Figure
R4099 T13390 T13376 parataxis Figure,coordinated
R410 T2911 T2912 advmod subsequently,map
R4100 T13391 T13390 nummod 5,Figure
R4101 T13392 T13390 punct ),Figure
R4102 T13393 T13365 punct .,identified
R4103 T13395 T13396 det The,region
R4104 T13396 T13398 nsubjpass region,sequenced
R4105 T13397 T13396 compound coding,region
R4106 T13399 T13396 prep of,region
R4107 T13400 T13401 det each,gene
R4108 T13401 T13399 pobj gene,of
R4109 T13402 T13398 auxpass was,sequenced
R411 T2849 T2846 advcl convert,designed
R4110 T13403 T13398 prep from,sequenced
R4111 T13404 T13405 det the,strain
R4112 T13405 T13403 pobj strain,from
R4113 T13406 T13405 compound CAST,strain
R4114 T13407 T13398 cc and,sequenced
R4115 T13408 T13398 conj compared,sequenced
R4116 T13409 T13408 prep to,compared
R4117 T13410 T13411 det the,sequence
R4118 T13411 T13409 pobj sequence,to
R4119 T13412 T13413 advmod publicly,available
R412 T2912 T2909 conj map,confirm
R4120 T13413 T13411 amod available,sequence
R4121 T13414 T13411 compound B6,sequence
R4122 T13415 T13416 aux to,identify
R4123 T13416 T13408 advcl identify,compared
R4124 T13417 T13416 dobj polymorphisms,identify
R4125 T13418 T13419 punct (,File
R4126 T13419 T13408 parataxis File,compared
R4127 T13420 T13419 amod Additional,File
R4128 T13421 T13419 nummod 4,File
R4129 T13422 T13419 punct ),File
R413 T2913 T2912 advmod fine,map
R4130 T13423 T13398 punct .,sequenced
R4131 T13425 T13426 det A,total
R4132 T13426 T13427 nsubjpass total,sequenced
R4133 T13428 T13426 prep of,total
R4134 T13429 T13430 nummod 94.492,kbp
R4135 T13430 T13428 pobj kbp,of
R4136 T13431 T13427 auxpass was,sequenced
R4137 T13432 T13433 punct (,CDS
R4138 T13433 T13427 parataxis CDS,sequenced
R4139 T13434 T13435 nummod 75.378,kbp
R414 T2914 T2912 dobj QTL,map
R4140 T13435 T13433 compound kbp,CDS
R4141 T13436 T13433 cc and,CDS
R4142 T13437 T13438 nummod 19.114,Kbp
R4143 T13438 T13439 nmod Kbp,region
R4144 T13439 T13433 conj region,CDS
R4145 T13440 T13438 nummod 5,Kbp
R4146 T13441 T13440 punct ',5
R4147 T13442 T13438 cc and,Kbp
R4148 T13443 T13438 conj 3,Kbp
R4149 T13444 T13443 punct ',3
R415 T2915 T2916 punct [,3
R4150 T13445 T13439 amod untranslated,region
R4151 T13446 T13439 punct (,region
R4152 T13447 T13439 appos UTR,region
R4153 T13448 T13439 punct ),region
R4154 T13449 T13433 punct ),CDS
R4155 T13450 T13427 punct ", ",sequenced
R4156 T13451 T13427 advcl representing,sequenced
R4157 T13452 T13453 nummod "25,083",acids
R4158 T13453 T13451 dobj acids,representing
R4159 T13454 T13453 compound amino,acids
R416 T2850 T2851 det a,trait
R4160 T13455 T13427 punct .,sequenced
R4161 T13457 T13458 nsubj Comparison,identified
R4162 T13459 T13457 prep with,Comparison
R4163 T13460 T13461 det the,assembly
R4164 T13461 T13459 pobj assembly,with
R4165 T13462 T13461 amod public,assembly
R4166 T13463 T13461 compound B6,assembly
R4167 T13464 T13465 punct (,Build
R4168 T13465 T13457 parataxis Build,Comparison
R4169 T13466 T13467 npadvmod May,University
R417 T2916 T2899 parataxis 3,considers
R4170 T13467 T13465 dep University,Build
R4171 T13468 T13466 npadvmod 2004,May
R4172 T13469 T13467 prep of,University
R4173 T13470 T13469 pobj California,of
R4174 T13471 T13467 punct ", ",University
R4175 T13472 T13473 compound Santa,Cruz
R4176 T13473 T13467 npadvmod Cruz,University
R4177 T13474 T13475 punct (,28
R4178 T13475 T13467 parataxis 28,University
R4179 T13476 T13475 dep UCSC,28
R418 T2917 T2916 punct ],3
R4180 T13477 T13475 punct [,28
R4181 T13478 T13475 punct ],28
R4182 T13479 T13475 punct ),28
R4183 T13480 T13481 compound mm5,assembly
R4184 T13481 T13465 dep assembly,Build
R4185 T13482 T13481 compound genome,assembly
R4186 T13483 T13465 punct ", ",Build
R4187 T13484 T13485 compound National,Center
R4188 T13485 T13465 dep Center,Build
R4189 T13486 T13485 prep for,Center
R419 T2851 T2849 dobj trait,convert
R4190 T13487 T13488 compound Biotechnology,Information
R4191 T13488 T13486 pobj Information,for
R4192 T13489 T13485 punct (,Center
R4193 T13490 T13485 appos NCBI,Center
R4194 T13491 T13485 punct ),Center
R4195 T13492 T13465 nummod 33,Build
R4196 T13493 T13465 punct ),Build
R4197 T13494 T13495 nummod 307,polymorphisms
R4198 T13495 T13458 dobj polymorphisms,identified
R4199 T13496 T13495 prep between,polymorphisms
R420 T2918 T2899 punct .,considers
R4200 T13497 T13496 pobj CAST,between
R4201 T13498 T13497 cc and,CAST
R4202 T13499 T13497 conj B6,CAST
R4203 T13500 T13458 punct .,identified
R4204 T13502 T13503 prep Of,were
R4205 T13504 T13502 pobj these,Of
R4206 T13505 T13503 punct ", ",were
R4207 T13506 T13503 nsubj 295,were
R4208 T13507 T13508 amod single,polymorphisms
R4209 T13508 T13503 attr polymorphisms,were
R421 T2920 T2921 advmod Traditionally,developed
R4210 T13509 T13508 compound nucleotide,polymorphisms
R4211 T13510 T13508 punct (,polymorphisms
R4212 T13511 T13508 appos SNP,polymorphisms
R4213 T13512 T13503 punct ),were
R4214 T13513 T13503 cc and,were
R4215 T13514 T13515 nsubj 12,were
R4216 T13515 T13503 conj were,were
R4217 T13516 T13515 attr insertions,were
R4218 T13517 T13516 cc or,insertions
R4219 T13518 T13516 conj deletions,insertions
R422 T2852 T2851 amod complex,trait
R4220 T13519 T13516 prep in,insertions
R4221 T13520 T13519 pobj CAST,in
R4222 T13521 T13522 punct (,File
R4223 T13522 T13503 parataxis File,were
R4224 T13523 T13522 amod Additional,File
R4225 T13524 T13522 nummod 4,File
R4226 T13525 T13522 punct ),File
R4227 T13526 T13503 punct .,were
R4228 T13528 T13529 predet All,insertions
R4229 T13529 T13531 nsubjpass insertions,located
R423 T2922 T2921 punct ", ",developed
R4230 T13530 T13529 nummod 12,insertions
R4231 T13532 T13529 cc or,insertions
R4232 T13533 T13529 conj deletions,insertions
R4233 T13534 T13531 auxpass were,located
R4234 T13535 T13531 prep within,located
R4235 T13536 T13537 nummod 5,UTRs
R4236 T13537 T13535 pobj UTRs,within
R4237 T13538 T13536 punct ',5
R4238 T13539 T13536 cc and,5
R4239 T13540 T13536 conj 3,5
R424 T2923 T2924 amod congenic,strains
R4240 T13541 T13540 punct ',3
R4241 T13542 T13531 punct .,located
R4242 T13544 T13545 compound Fifty,six
R4243 T13545 T13547 nummod six,SNP
R4244 T13546 T13545 punct -,six
R4245 T13547 T13549 nsubjpass SNP,identified
R4246 T13548 T13547 amod nonsynonomous,SNP
R4247 T13550 T13547 punct (,SNP
R4248 T13551 T13547 appos nsSNP,SNP
R4249 T13552 T13549 punct ),identified
R425 T2853 T2851 amod polygenic,trait
R4250 T13553 T13549 auxpass were,identified
R4251 T13554 T13549 prep in,identified
R4252 T13555 T13556 nummod 14,genes
R4253 T13556 T13554 pobj genes,in
R4254 T13557 T13556 amod different,genes
R4255 T13558 T13559 punct (,File
R4256 T13559 T13549 parataxis File,identified
R4257 T13560 T13559 amod Additional,File
R4258 T13561 T13559 nummod 4,File
R4259 T13562 T13559 punct ),File
R426 T2924 T2921 nsubjpass strains,developed
R4260 T13563 T13549 punct .,identified
R4261 T13565 T13566 nsubj PolyPhen,are
R4262 T13567 T13568 punct [,29
R4263 T13568 T13565 parataxis 29,PolyPhen
R4264 T13569 T13568 punct ],29
R4265 T13570 T13565 cc and,PolyPhen
R4266 T13571 T13565 conj SIFT,PolyPhen
R4267 T13572 T13573 punct [,30
R4268 T13573 T13571 parataxis 30,SIFT
R4269 T13574 T13573 punct ],30
R427 T2925 T2921 auxpass are,developed
R4270 T13575 T13576 compound software,programs
R4271 T13576 T13566 attr programs,are
R4272 T13577 T13576 acl designed,programs
R4273 T13578 T13579 aux to,identify
R4274 T13579 T13577 advcl identify,designed
R4275 T13580 T13579 dobj nsSNP,identify
R4276 T13581 T13582 dep which,alter
R4277 T13582 T13580 relcl alter,nsSNP
R4278 T13583 T13582 advmod potentially,alter
R4279 T13584 T13585 compound protein,function
R428 T2854 T2849 prep into,convert
R4280 T13585 T13582 dobj function,alter
R4281 T13586 T13579 prep by,identify
R4282 T13587 T13586 pcomp evaluating,by
R4283 T13588 T13589 amod evolutionary,conservation
R4284 T13589 T13587 dobj conservation,evaluating
R4285 T13590 T13587 prep at,evaluating
R4286 T13591 T13592 amod specific,residues
R4287 T13592 T13590 pobj residues,at
R4288 T13593 T13594 compound amino,acid
R4289 T13594 T13592 compound acid,residues
R429 T2926 T2921 prep by,developed
R4290 T13595 T13587 advcl using,evaluating
R4291 T13596 T13597 det a,alignment
R4292 T13597 T13595 dobj alignment,using
R4293 T13598 T13599 amod multiple,sequence
R4294 T13599 T13597 compound sequence,alignment
R4295 T13600 T13597 prep of,alignment
R4296 T13601 T13602 compound protein,sequences
R4297 T13602 T13600 pobj sequences,of
R4298 T13603 T13602 amod homologous,sequences
R4299 T13604 T13603 prep to,homologous
R430 T2927 T2926 pcomp introgressing,by
R4300 T13605 T13606 det the,query
R4301 T13606 T13604 pobj query,to
R4302 T13607 T13566 punct .,are
R4303 T13609 T13610 advmod When,applied
R4304 T13610 T13611 advcl applied,predicted
R4305 T13612 T13610 prep to,applied
R4306 T13613 T13614 poss our,set
R4307 T13614 T13612 pobj set,to
R4308 T13615 T13614 compound data,set
R4309 T13616 T13611 nsubj PolyPhen,predicted
R431 T2928 T2929 compound QTL,alleles
R4310 T13617 T13616 punct ", ",PolyPhen
R4311 T13618 T13616 conj SIFT,PolyPhen
R4312 T13619 T13618 cc or,SIFT
R4313 T13620 T13621 det both,programs
R4314 T13621 T13618 conj programs,SIFT
R4315 T13622 T13623 mark that,alter
R4316 T13623 T13611 ccomp alter,predicted
R4317 T13624 T13625 quantmod 15,56
R4318 T13625 T13628 nummod 56,nsSNP
R4319 T13626 T13625 quantmod of,56
R432 T2929 T2927 dobj alleles,introgressing
R4320 T13627 T13625 quantmod the,56
R4321 T13628 T13623 nsubj nsSNP,alter
R4322 T13629 T13628 prep in,nsSNP
R4323 T13630 T13631 nummod 9,genes
R4324 T13631 T13629 pobj genes,in
R4325 T13632 T13631 amod different,genes
R4326 T13633 T13623 aux would,alter
R4327 T13634 T13623 advmod possibly,alter
R4328 T13635 T13636 compound protein,function
R4329 T13636 T13623 dobj function,alter
R433 T2855 T2854 pobj one,into
R4330 T13637 T13638 punct (,Table
R4331 T13638 T13611 parataxis Table,predicted
R4332 T13639 T13638 nummod 7,Table
R4333 T13640 T13638 punct ),Table
R4334 T13641 T13611 punct .,predicted
R4337 T17718 T17719 npadvmod Speed,congenic
R4338 T17719 T17720 amod congenic,strains
R4339 T17720 T17721 nsubj strains,provide
R434 T2930 T2929 prep from,alleles
R4340 T17722 T17723 det a,approach
R4341 T17723 T17721 dobj approach,provide
R4342 T17724 T17723 amod powerful,approach
R4343 T17725 T17726 aux to,confirm
R4344 T17726 T17723 acl confirm,approach
R4345 T17727 T17726 cc and,confirm
R4346 T17728 T17729 advmod physically,confine
R4347 T17729 T17726 conj confine,confirm
R4348 T17730 T17729 dobj QTL,confine
R4349 T17731 T17729 prep within,confine
R435 T2931 T2932 det a,strain
R4350 T17732 T17731 pobj intervals,within
R4351 T17733 T17732 acl defined,intervals
R4352 T17734 T17733 prep by,defined
R4353 T17735 T17736 amod molecular,markers
R4354 T17736 T17734 pobj markers,by
R4355 T17737 T17721 punct .,provide
R4356 T17739 T17740 prep In,isolated
R4357 T17741 T17742 det the,study
R4358 T17742 T17739 pobj study,In
R4359 T17743 T17742 amod current,study
R436 T2932 T2930 pobj strain,from
R4360 T17744 T17740 punct ", ",isolated
R4361 T17745 T17746 advmod approximately,20
R4362 T17746 T17747 nummod 20,%
R4363 T17747 T17740 nsubjpass %,isolated
R4364 T17748 T17747 prep of,%
R4365 T17749 T17750 det the,genome
R4366 T17750 T17748 pobj genome,of
R4367 T17751 T17750 compound CAST,genome
R4368 T17752 T17750 acl harboring,genome
R4369 T17753 T17754 advmod all,QTL
R437 T2933 T2932 compound donor,strain
R4370 T17754 T17752 dobj QTL,harboring
R4371 T17755 T17756 advmod previously,detected
R4372 T17756 T17754 amod detected,QTL
R4373 T17757 T17758 nmod growth,composition
R4374 T17758 T17754 compound composition,QTL
R4375 T17759 T17757 cc and,growth
R4376 T17760 T17757 conj carcass,growth
R4377 T17761 T17740 auxpass was,isolated
R4378 T17762 T17740 prep on,isolated
R4379 T17763 T17764 det an,background
R438 T2934 T2932 punct ", ",strain
R4380 T17764 T17762 pobj background,on
R4381 T17765 T17764 nmod HG,background
R4382 T17766 T17765 cc or,HG
R4383 T17767 T17765 conj B6,HG
R4384 T17768 T17740 prep through,isolated
R4385 T17769 T17770 det the,development
R4386 T17770 T17768 pobj development,through
R4387 T17771 T17770 prep of,development
R4388 T17772 T17773 nummod 14,strains
R4389 T17773 T17771 pobj strains,of
R439 T2856 T2857 dep that,is
R4390 T17774 T17775 npadvmod speed,congenic
R4391 T17775 T17773 amod congenic,strains
R4392 T17776 T17740 punct .,isolated
R4393 T17778 T17779 nummod Two,panels
R4394 T17779 T17783 nsubjpass panels,developed
R4395 T17780 T17779 amod distinct,panels
R4396 T17781 T17782 npadvmod speed,congenic
R4397 T17782 T17779 amod congenic,panels
R4398 T17783 T17785 ccomp developed,provided
R4399 T17784 T17783 auxpass were,developed
R440 T2935 T2936 poss whose,boundaries
R4400 T17786 T17785 punct ", ",provided
R4401 T17787 T17788 det the,first
R4402 T17788 T17785 nsubj first,provided
R4403 T17789 T17790 det a,isolation
R4404 T17790 T17785 dobj isolation,provided
R4405 T17791 T17790 amod comprehensive,isolation
R4406 T17792 T17790 prep of,isolation
R4407 T17793 T17794 det all,QTL
R4408 T17794 T17792 pobj QTL,of
R4409 T17795 T17794 compound MMU2,QTL
R441 T2936 T2937 dep boundaries,defined
R4410 T17796 T17794 prep between,QTL
R4411 T17797 T17798 det the,strains
R4412 T17798 T17796 pobj strains,between
R4413 T17799 T17798 nmod B6,strains
R4414 T17800 T17799 punct ", ",B6
R4415 T17801 T17799 conj HG,B6
R4416 T17802 T17801 cc and,HG
R4417 T17803 T17801 conj CAST,HG
R4418 T17804 T17785 cc and,provided
R4419 T17805 T17806 det the,second
R442 T2857 T2855 relcl is,one
R4420 T17806 T17807 nsubj second,targeted
R4421 T17807 T17785 conj targeted,provided
R4422 T17808 T17809 det all,QTL
R4423 T17809 T17807 dobj QTL,targeted
R4424 T17810 T17809 prep outside,QTL
R4425 T17811 T17810 prep of,outside
R4426 T17812 T17811 pobj MMU2,of
R4427 T17813 T17785 punct .,provided
R4428 T17815 T17816 det Each,strain
R4429 T17816 T17819 nsubj strain,exhibited
R443 T2937 T2932 relcl defined,strain
R4430 T17817 T17818 advmod successfully,characterized
R4431 T17818 T17816 amod characterized,strain
R4432 T17820 T17821 amod phenotypic,differences
R4433 T17821 T17819 dobj differences,exhibited
R4434 T17822 T17819 advcl relative,exhibited
R4435 T17823 T17822 prep to,relative
R4436 T17824 T17825 compound control,mice
R4437 T17825 T17823 pobj mice,to
R4438 T17826 T17819 punct .,exhibited
R4439 T17828 T17829 det These,strains
R444 T2858 T2859 advmod mono,oligogenic
R4440 T17829 T17830 nsubj strains,represent
R4441 T17831 T17832 amod important,resources
R4442 T17832 T17830 dobj resources,represent
R4443 T17833 T17830 cc and,represent
R4444 T17834 T17830 conj provide,represent
R4445 T17835 T17836 det the,resource
R4446 T17836 T17834 dobj resource,provide
R4447 T17837 T17836 amod genetic,resource
R4448 T17838 T17839 aux to,clone
R4449 T17839 T17836 advcl clone,resource
R445 T2938 T2937 auxpass are,defined
R4450 T17840 T17839 advmod positionally,clone
R4451 T17841 T17842 amod numerous,genes
R4452 T17842 T17839 dobj genes,clone
R4453 T17843 T17844 amod quantitative,trait
R4454 T18103 T18100 pobj variation,due
R4455 T17844 T17842 compound trait,genes
R4456 T18104 T18103 prep within,variation
R4457 T17845 T17830 punct .,represent
R4458 T18105 T18106 det each,region
R4459 T18106 T18104 pobj region,within
R446 T2939 T2937 agent by,defined
R4460 T17847 T17848 nummod One,criticism
R4461 T18107 T18106 compound donor,region
R4462 T18108 T18076 punct .,screened
R4463 T17848 T17849 nsubj criticism,is
R4464 T18110 T18111 mark Although,put
R4465 T18111 T18115 advcl put,confound
R4466 T17850 T17848 prep of,criticism
R4467 T18112 T18113 amod great,effort
R4468 T18113 T18111 nsubjpass effort,put
R4469 T18114 T18111 auxpass was,put
R447 T2940 T2941 amod genetic,markers
R4470 T17851 T17852 det the,approach
R4471 T18116 T18111 prt forth,put
R4472 T18117 T18118 aux to,eliminate
R4473 T17852 T17850 pobj approach,of
R4474 T18118 T18111 advcl eliminate,put
R4475 T18119 T18120 amod non-donor,region
R4476 T17853 T17854 npadvmod speed,congenic
R4477 T18120 T18121 nmod region,effects
R4478 T18121 T18118 dobj effects,eliminate
R4479 T18122 T18121 amod direct,effects
R448 T2859 T2857 acomp oligogenic,is
R4480 T17854 T17852 amod congenic,approach
R4481 T18123 T18121 amod genetic,effects
R4482 T18124 T18115 punct ", ",confound
R4483 T18125 T18126 amod other,factors
R4484 T17855 T17856 det the,potential
R4485 T18126 T18115 nsubj factors,confound
R4486 T17856 T17849 attr potential,is
R4487 T17857 T17858 mark for,reside
R4488 T17858 T17856 advcl reside,potential
R4489 T17859 T17858 nsubj QTL,reside
R449 T2941 T2939 pobj markers,by
R4490 T18127 T18128 amod such,as
R4491 T18128 T18126 prep as,factors
R4492 T18129 T18130 amod maternal,genotype
R4493 T18130 T18128 pobj genotype,as
R4494 T17860 T17858 aux to,reside
R4495 T18131 T18132 punct (,differed
R4496 T18132 T18130 parataxis differed,genotype
R4497 T18133 T18134 amod maternal,genotype
R4498 T17861 T17858 prep among,reside
R4499 T18134 T18132 nsubj genotype,differed
R450 T2942 T2927 punct ", ",introgressing
R4500 T17862 T17863 amod unwanted,alleles
R4501 T18135 T18134 prep for,genotype
R4502 T18136 T18137 det each,congenic
R4503 T18137 T18135 pobj congenic,for
R4504 T18138 T18134 cc versus,genotype
R4505 T18139 T18140 compound control,dams
R4506 T17863 T17861 pobj alleles,among
R4507 T18140 T18134 conj dams,genotype
R4508 T18141 T18132 punct ),differed
R4509 T18142 T18126 cc and,factors
R451 T2943 T2927 prep on,introgressing
R4510 T18143 T18144 amod environmental,effects
R4511 T18144 T18126 conj effects,factors
R4512 T18145 T18115 aux could,confound
R4513 T18146 T18147 poss our,results
R4514 T18147 T18115 dobj results,confound
R4515 T18148 T18115 punct .,confound
R4516 T17864 T17863 compound donor,alleles
R4517 T18150 T18151 amod Maternal,genotype
R4518 T18151 T18152 compound genotype,effects
R4519 T17865 T17866 neg not,eliminated
R452 T2860 T2859 punct -,oligogenic
R4520 T18152 T18153 nsubjpass effects,observed
R4521 T18154 T18152 prep on,effects
R4522 T17866 T17863 acl eliminated,alleles
R4523 T18155 T18154 pobj growth,on
R4524 T18156 T18155 cc and,growth
R4525 T17867 T17866 prep during,eliminated
R4526 T18157 T18155 conj obesity,growth
R4527 T18158 T18153 aux have,observed
R4528 T18159 T18153 auxpass been,observed
R4529 T17868 T17867 pobj backcrossing,during
R453 T2944 T2945 det the,background
R4530 T18160 T18153 prep in,observed
R4531 T18161 T18162 det a,number
R4532 T18162 T18160 pobj number,in
R4533 T17869 T17849 punct .,is
R4534 T18163 T18162 prep of,number
R4535 T18164 T18165 compound mouse,crosses
R4536 T17871 T17872 prep In,be
R4537 T18165 T18163 pobj crosses,of
R4538 T18166 T18167 punct [,8
R4539 T18167 T18153 parataxis 8,observed
R454 T2945 T2943 pobj background,on
R4540 T18168 T18167 punct ",",8
R4541 T17873 T17874 det this,case
R4542 T18169 T18167 appos 32,8
R4543 T18170 T18171 punct -,35
R4544 T18171 T18169 prep 35,32
R4545 T18172 T18167 punct ],8
R4546 T18173 T18153 cc and,observed
R4547 T18174 T18175 poss their,existence
R4548 T18175 T18176 nsubjpass existence,discounted
R4549 T17874 T17871 pobj case,In
R455 T2946 T2945 amod genetic,background
R4550 T18176 T18153 conj discounted,observed
R4551 T18177 T18175 prep in,existence
R4552 T18178 T18179 det the,cross
R4553 T17875 T17872 nsubj differences,be
R4554 T18179 T18177 pobj cross,in
R4555 T18180 T18179 amod current,cross
R4556 T18181 T18176 aux can,discounted
R4557 T17876 T17875 prep between,differences
R4558 T18182 T18176 neg not,discounted
R4559 T18183 T18176 auxpass be,discounted
R456 T2861 T2859 cc or,oligogenic
R4560 T18184 T18176 punct .,discounted
R4561 T17877 T17878 det the,strains
R4562 T18186 T18187 advmod However,provide
R4563 T17878 T17876 pobj strains,between
R4564 T18188 T18187 punct ", ",provide
R4565 T18189 T18190 poss our,congenics
R4566 T17879 T17878 amod congenic,strains
R4567 T18190 T18187 nsubj congenics,provide
R4568 T18191 T18192 det the,resource
R4569 T17880 T17879 cc and,congenic
R457 T2947 T2945 prep of,background
R4570 T18192 T18187 dobj resource,provide
R4571 T18193 T18192 amod ideal,resource
R4572 T18194 T18192 nmod foundation,resource
R4573 T17881 T17879 conj control,congenic
R4574 T18195 T18192 amod genomic,resource
R4575 T18196 T18197 aux to,test
R4576 T18197 T18192 advcl test,resource
R4577 T17882 T17872 aux would,be
R4578 T18198 T18197 prep for,test
R4579 T18199 T18200 det the,influence
R458 T2948 T2949 det a,strain
R4580 T18200 T18198 pobj influence,for
R4581 T17883 T17872 prep due,be
R4582 T18201 T18200 prep of,influence
R4583 T18202 T18201 pobj any,of
R4584 T18203 T18202 prep of,any
R4585 T17884 T17883 prep in,due
R4586 T18204 T18205 det these,effects
R4587 T18205 T18203 pobj effects,of
R4588 T17885 T17884 pobj part,in
R4589 T17886 T17885 cc or,part
R459 T2949 T2947 pobj strain,of
R4590 T18206 T18205 amod possible,effects
R4591 T18207 T18187 punct .,provide
R4592 T17887 T17885 conj whole,part
R4593 T18209 T18210 amod Future,experiments
R4594 T18210 T18213 nsubjpass experiments,designed
R4595 T18211 T18212 amod fine,mapping
R4596 T17888 T17883 pcomp to,due
R4597 T18212 T18210 compound mapping,experiments
R4598 T17889 T17890 det these,alleles
R4599 T17890 T17883 pobj alleles,due
R460 T2862 T2837 punct .,are
R4600 T17891 T17890 amod contaminating,alleles
R4601 T17892 T17872 punct .,be
R4602 T17894 T17895 nsubj We,took
R4603 T18214 T18213 aux can,designed
R4604 T18215 T18213 auxpass be,designed
R4605 T18216 T18217 aux to,randomize
R4606 T17896 T17897 amod several,precautions
R4607 T18217 T18213 advcl randomize,designed
R4608 T18218 T18219 det the,influences
R4609 T17897 T17895 dobj precautions,took
R461 T2950 T2949 compound recipient,strain
R4610 T18219 T18217 dobj influences,randomize
R4611 T18220 T18219 prep of,influences
R4612 T18221 T18222 det any,alleles
R4613 T17898 T17899 aux to,reduce
R4614 T18222 T18220 pobj alleles,of
R4615 T18223 T18222 amod contaminating,alleles
R4616 T17899 T17895 advcl reduce,took
R4617 T18224 T18222 compound donor,alleles
R4618 T18225 T18222 cc and,alleles
R4619 T18226 T18227 amod environmental,differences
R462 T2951 T2927 prep via,introgressing
R4620 T17900 T17901 det the,probability
R4621 T18227 T18222 conj differences,alleles
R4622 T18228 T18217 punct ", ",randomize
R4623 T18229 T18230 advmod as,as
R4624 T17901 T17899 dobj probability,reduce
R4625 T18230 T18217 cc as,randomize
R4626 T18231 T18230 advmod well,as
R4627 T18232 T18217 conj test,randomize
R4628 T17902 T17901 prep of,probability
R4629 T18233 T18232 prep for,test
R463 T2864 T2865 nsubjpass This,accomplished
R4630 T18234 T18235 amod maternal,genotype
R4631 T17903 T17904 det this,occurrence
R4632 T18235 T18236 compound genotype,effects
R4633 T18236 T18233 pobj effects,for
R4634 T18237 T18213 punct .,designed
R4635 T17904 T17902 pobj occurrence,of
R4636 T18239 T18240 nsubj MMU2,is
R4637 T17905 T17895 punct .,took
R4638 T18241 T18242 det a,hotspot
R4639 T18242 T18240 attr hotspot,is
R464 T2952 T2953 nummod 10,backcrosses
R4640 T17907 T17908 advmod First,developed
R4641 T18243 T18242 prep for,hotspot
R4642 T18244 T18245 nmod growth,QTL
R4643 T18245 T18243 pobj QTL,for
R4644 T18246 T18244 cc and,growth
R4645 T17909 T17908 punct ", ",developed
R4646 T18247 T18244 conj obesity,growth
R4647 T18248 T18240 punct .,is
R4648 T18250 T18251 quantmod Over,30
R4649 T18251 T18252 nummod 30,QTL
R465 T2953 T2951 pobj backcrosses,via
R4650 T18252 T18253 nsubjpass QTL,identified
R4651 T17910 T17911 poss our,strains
R4652 T18254 T18253 aux have,identified
R4653 T18255 T18253 auxpass been,identified
R4654 T17911 T17908 nsubjpass strains,developed
R4655 T18256 T18253 prep in,identified
R4656 T18257 T18258 amod various,experiments
R4657 T18258 T18256 pobj experiments,in
R4658 T17912 T17911 compound control,strains
R4659 T18259 T18260 punct [,2
R466 T2954 T2955 punct [,4
R4660 T18260 T18253 parataxis 2,identified
R4661 T17913 T17908 auxpass were,developed
R4662 T18261 T18260 nummod 1,2
R4663 T18262 T18260 punct ",",2
R4664 T17914 T17908 prep from,developed
R4665 T18263 T18260 punct ],2
R4666 T18264 T18253 punct .,identified
R4667 T17915 T17914 pobj mice,from
R4668 T18266 T18267 amod Several,QTL
R4669 T18267 T18273 nsubjpass QTL,isolated
R467 T2955 T2927 parataxis 4,introgressing
R4670 T18268 T18269 advmod previously,reported
R4671 T17916 T17915 acl undergoing,mice
R4672 T18269 T18267 amod reported,QTL
R4673 T18270 T18269 cc or,reported
R4674 T18271 T18269 conj novel,reported
R4675 T17917 T17918 det the,selection
R4676 T18272 T18267 compound MMU2,QTL
R4677 T18274 T18273 aux have,isolated
R4678 T17918 T17916 dobj selection,undergoing
R4679 T18275 T18273 auxpass been,isolated
R468 T2956 T2955 punct ],4
R4680 T18276 T18273 cc and,isolated
R4681 T17919 T17918 amod same,selection
R4682 T18277 T18273 conj characterized,isolated
R4683 T18278 T18277 advcl using,characterized
R4684 T18279 T18280 amod congenic,strains
R4685 T17920 T17918 prep as,selection
R4686 T18280 T18278 dobj strains,using
R4687 T18281 T18282 punct [,7
R4688 T18282 T18277 parataxis 7,characterized
R4689 T17921 T17920 pobj all,as
R469 T2866 T2865 auxpass is,accomplished
R4690 T18283 T18282 punct ",",7
R4691 T18284 T18282 appos 9,7
R4692 T18285 T18286 punct -,11
R4693 T17922 T17921 prep of,all
R4694 T18286 T18284 prep 11,9
R4695 T18287 T18282 punct ",",7
R4696 T18288 T18282 appos 36,7
R4697 T17923 T17924 det the,congenics
R4698 T18289 T18282 punct ],7
R4699 T18290 T18273 punct .,isolated
R470 T2957 T2921 punct .,developed
R4700 T18292 T18293 poss Our,findings
R4701 T18293 T18294 nsubj findings,are
R4702 T17924 T17922 pobj congenics,of
R4703 T18295 T18296 neg no,different
R4704 T18296 T18294 acomp different,are
R4705 T17925 T17924 amod other,congenics
R4706 T18297 T18296 cc and,different
R4707 T18298 T18296 conj indicate,different
R4708 T18299 T18300 mark that,is
R4709 T17926 T17908 punct .,developed
R471 T2959 T2960 mark While,straightforward
R4710 T18300 T18298 ccomp is,indicate
R4711 T18301 T18300 nsubj MMU2,is
R4712 T17928 T17929 advmod Therefore,is
R4713 T18302 T18303 advmod highly,complex
R4714 T17930 T17929 punct ", ",is
R4715 T17931 T17929 nsubj it,is
R4716 T17932 T17929 acomp possible,is
R4717 T18303 T18300 acomp complex,is
R4718 T17933 T17934 mark that,shared
R4719 T18304 T18300 prep with,is
R472 T2960 T2962 advcl straightforward,is
R4720 T18305 T18304 pobj regards,with
R4721 T17934 T17929 ccomp shared,is
R4722 T18306 T18305 prep to,regards
R4723 T18307 T18308 nsubj genes,affecting
R4724 T18308 T18306 pcomp affecting,to
R4725 T17935 T17936 det any,QTL
R4726 T18309 T18308 dobj growth,affecting
R4727 T18310 T18309 cc and,growth
R4728 T18311 T18309 conj obesity,growth
R4729 T17936 T17934 nsubjpass QTL,shared
R473 T2867 T2865 prep by,accomplished
R4730 T17937 T17936 amod unwanted,QTL
R4731 T18312 T18294 punct .,are
R4732 T17938 T17936 cc or,QTL
R4733 T18314 T18315 det The,nature
R4734 T18315 T18317 nsubj nature,allowed
R4735 T17939 T17936 conj mutations,QTL
R4736 T18316 T18315 amod overlapping,nature
R4737 T17940 T17939 acl arising,mutations
R4738 T18318 T18315 prep of,nature
R4739 T18319 T18320 poss our,strains
R474 T2961 T2960 advmod technically,straightforward
R4740 T18320 T18318 pobj strains,of
R4741 T17941 T17940 prep during,arising
R4742 T18321 T18320 compound MMU2,strains
R4743 T18322 T18323 nsubj us,parse
R4744 T17942 T17943 amod congenic,construction
R4745 T18323 T18317 ccomp parse,allowed
R4746 T18324 T18323 aux to,parse
R4747 T17943 T17941 pobj construction,during
R4748 T18325 T18326 det the,chromosome
R4749 T18326 T18323 dobj chromosome,parse
R475 T2963 T2962 nsubj this,is
R4750 T18327 T18323 prep into,parse
R4751 T18328 T18329 nummod five,regions
R4752 T18329 T18327 pobj regions,into
R4753 T17944 T17934 auxpass are,shared
R4754 T18330 T18329 punct (,regions
R4755 T18331 T18332 nmod Regions,I
R4756 T18332 T18329 appos I,regions
R4757 T17945 T17934 prep between,shared
R4758 T18333 T18334 punct –,V
R4759 T18334 T18332 prep V,I
R476 T2868 T2867 pcomp eliminating,by
R4760 T18335 T18317 punct ),allowed
R4761 T18336 T18337 punct (,Figure
R4762 T17946 T17947 det all,strains
R4763 T18337 T18317 parataxis Figure,allowed
R4764 T18338 T18337 nummod 2,Figure
R4765 T17947 T17945 pobj strains,between
R4766 T17948 T17929 punct .,is
R4767 T17950 T17951 advmod More,importantly
R4768 T17951 T17952 advmod importantly,have
R4769 T17953 T17952 punct ", ",have
R477 T2964 T2965 det a,endeavor
R4770 T17954 T17952 nsubj we,have
R4771 T18339 T18337 punct ),Figure
R4772 T17955 T17952 dobj knowledge,have
R4773 T18340 T18317 punct .,allowed
R4774 T18342 T18343 det The,data
R4775 T18343 T18344 nsubj data,support
R4776 T18345 T18346 det the,presence
R4777 T18346 T18344 dobj presence,support
R4778 T18347 T18346 prep of,presence
R4779 T18348 T18349 advmod at,one
R478 T2965 T2962 attr endeavor,is
R4780 T17956 T17955 prep of,knowledge
R4781 T18349 T18351 nummod one,QTL
R4782 T18350 T18349 advmod least,one
R4783 T18351 T18347 pobj QTL,of
R4784 T18352 T18346 prep in,presence
R4785 T17957 T17958 det all,QTL
R4786 T18353 T18352 pobj each,in
R4787 T18354 T18353 prep of,each
R4788 T18355 T18356 det the,regions
R4789 T17958 T17956 pobj QTL,of
R479 T2966 T2967 npadvmod time,consuming
R4790 T18356 T18354 pobj regions,of
R4791 T18357 T18356 nummod five,regions
R4792 T17959 T17958 amod large,QTL
R4793 T18358 T18359 punct (,Figure
R4794 T18359 T18344 parataxis Figure,support
R4795 T18360 T18359 nummod 2,Figure
R4796 T17960 T17961 advmod previously,detected
R4797 T18361 T18359 punct ),Figure
R4798 T18362 T18344 punct .,support
R4799 T17961 T17958 amod detected,QTL
R480 T2869 T2868 xcomp segregating,eliminating
R4800 T18364 T18365 nsubj Each,impact
R4801 T17962 T17958 nmod growth,QTL
R4802 T18366 T18364 prep of,Each
R4803 T18367 T18368 det the,five
R4804 T18368 T18366 pobj five,of
R4805 T18369 T18365 advmod pleiotropically,impact
R4806 T18370 T18371 preconj both,growth
R4807 T17963 T17962 cc and,growth
R4808 T18371 T18365 dobj growth,impact
R4809 T18372 T18371 cc and,growth
R481 T2967 T2965 amod consuming,endeavor
R4810 T18373 T18371 conj obesity,growth
R4811 T17964 T17962 conj obesity,growth
R4812 T18374 T18365 punct ", ",impact
R4813 T18375 T18376 mark although,to
R4814 T17965 T17958 prep in,QTL
R4815 T18376 T18365 advcl to,impact
R4816 T18377 T18378 amod varying,degrees
R4817 T18378 T18376 pobj degrees,to
R4818 T17966 T17967 det the,cross
R4819 T18379 T18365 punct .,impact
R482 T2968 T2965 acl taking,endeavor
R4820 T17967 T17965 pobj cross,in
R4821 T18381 T18382 prep In,adds
R4822 T18383 T18381 pobj addition,In
R4823 T17968 T17967 amod current,cross
R4824 T18384 T18383 prep to,addition
R4825 T18385 T18386 det the,number
R4826 T17969 T17970 punct [,24
R4827 T18386 T18384 pobj number,to
R4828 T18387 T18386 amod large,number
R4829 T18388 T18386 prep of,number
R483 T2969 T2970 quantmod over,three
R4830 T17970 T17952 parataxis 24,have
R4831 T18389 T18390 compound MMU2,QTL
R4832 T18390 T18388 pobj QTL,of
R4833 T18391 T18382 punct ", ",adds
R4834 T17971 T17970 punct ],24
R4835 T17972 T17952 punct .,have
R4836 T17974 T17975 advcl Using,increased
R4837 T17976 T17977 det this,information
R4838 T18392 T18393 det the,presence
R4839 T17977 T17974 dobj information,Using
R484 T2870 T2871 amod genetic,variation
R4840 T18393 T18382 nsubj presence,adds
R4841 T18394 T18393 prep of,presence
R4842 T17978 T17975 nsubj we,increased
R4843 T18395 T18394 pobj hg,of
R4844 T18396 T18382 dobj complexity,adds
R4845 T17979 T17980 det the,density
R4846 T18397 T18382 prep by,adds
R4847 T18398 T18397 preconj either,by
R4848 T18399 T18397 conj eliciting,by
R4849 T17980 T17975 dobj density,increased
R485 T2970 T2971 nummod three,years
R4850 T18400 T18399 dobj interactions,eliciting
R4851 T18401 T18400 prep with,interactions
R4852 T17981 T17980 prep of,density
R4853 T18402 T18403 det the,QTL
R4854 T18403 T18401 pobj QTL,with
R4855 T18404 T18403 amod same,QTL
R4856 T18405 T18397 cc or,by
R4857 T18406 T18397 conj by,by
R4858 T17982 T17981 pobj markers,of
R4859 T18407 T18406 pcomp inducing,by
R486 T2971 T2968 dobj years,taking
R4860 T18408 T18409 det the,expression
R4861 T18409 T18407 dobj expression,inducing
R4862 T17983 T17980 prep in,density
R4863 T18410 T18409 prep of,expression
R4864 T18411 T18412 amod novel,QTL
R4865 T18412 T18410 pobj QTL,of
R4866 T17984 T17985 det each,region
R4867 T18413 T18382 punct .,adds
R4868 T17985 T17983 pobj region,in
R4869 T18415 T18416 det The,region
R487 T2972 T2973 aux to,construct
R4870 T18416 T18419 nsubj region,contains
R4871 T18417 T18416 nmod 2P,region
R4872 T17986 T17985 compound QTL,region
R4873 T17987 T17988 punct (,Table
R4874 T18418 T18416 amod unique,region
R4875 T17988 T17975 parataxis Table,increased
R4876 T18420 T18416 punct (,region
R4877 T17989 T17990 nmod MMU,1
R4878 T18421 T18416 appos Region,region
R4879 T18422 T18421 nummod I,Region
R488 T2973 T2968 advcl construct,taking
R4880 T17990 T17988 dep 1,Table
R4881 T18423 T18419 punct ),contains
R4882 T18424 T18425 det an,modifier
R4883 T18425 T18419 dobj modifier,contains
R4884 T17991 T17990 punct ", ",1
R4885 T18426 T18425 compound hg,modifier
R4886 T18427 T18425 prep with,modifier
R4887 T17992 T17990 conj 2,1
R4888 T18428 T18429 amod large,effects
R4889 T18429 T18427 pobj effects,with
R489 T2974 T2975 det a,strain
R4890 T17993 T17992 punct ", ",2
R4891 T18430 T18429 prep on,effects
R4892 T18431 T18430 pobj growth,on
R4893 T17994 T17992 conj 5,2
R4894 T18432 T18429 cc and,effects
R4895 T18433 T18434 amod smaller,effects
R4896 T17995 T17994 punct ", ",5
R4897 T18434 T18429 conj effects,effects
R4898 T18435 T18434 prep on,effects
R4899 T18436 T18435 pobj obesity,on
R490 T2975 T2973 dobj strain,construct
R4900 T17996 T17994 conj 8,5
R4901 T18437 T18438 punct (,Table
R4902 T18438 T18419 parataxis Table,contains
R4903 T18439 T18438 nummod 3,Table
R4904 T17997 T17996 punct ", ",8
R4905 T18440 T18438 punct ),Table
R4906 T18441 T18419 punct .,contains
R4907 T18443 T18444 prep In,affect
R4908 T17998 T17996 conj 9,8
R4909 T18445 T18443 pobj contrast,In
R491 T2871 T2869 dobj variation,segregating
R4910 T18446 T18444 punct ", ",affect
R4911 T18447 T18444 nsubj interactions,affect
R4912 T17999 T17998 punct ", ",9
R4913 T18448 T18447 prep between,interactions
R4914 T18449 T18450 compound 2PM,2M
R4915 T18450 T18452 compound 2M,QTL
R4916 T18000 T17998 conj 11,9
R4917 T18451 T18450 punct /,2M
R4918 T18452 T18448 pobj QTL,between
R4919 T18001 T18000 cc and,11
R492 T2976 T2975 amod single,strain
R4920 T18453 T18452 cc and,QTL
R4921 T18454 T18452 conj hg,QTL
R4922 T18455 T18444 advmod primarily,affect
R4923 T18002 T18000 conj 17,11
R4924 T18456 T18457 compound fat,deposition
R4925 T18457 T18444 dobj deposition,affect
R4926 T18003 T17988 punct ;,Table
R4927 T18458 T18459 punct (,Table
R4928 T18459 T18444 parataxis Table,affect
R4929 T18460 T18459 nummod 3,Table
R493 T2977 T2962 punct .,is
R4930 T18004 T17988 nummod 1,Table
R4931 T18461 T18459 punct ),Table
R4932 T18462 T18444 punct .,affect
R4933 T18005 T17988 cc and,Table
R4934 T18464 T18465 mark As,illustrated
R4935 T18465 T18466 advcl illustrated,exhibits
R4936 T18006 T18007 amod Additional,File
R4937 T18467 T18465 prep in,illustrated
R4938 T18007 T17988 conj File,Table
R4939 T18468 T18467 pobj Figure,in
R494 T2872 T2869 prep outside,segregating
R4940 T18008 T18007 nummod 1,File
R4941 T18009 T17988 punct ),Table
R4942 T18010 T17975 punct ", ",increased
R4943 T18011 T17975 advcl ensuring,increased
R4944 T18012 T18013 det the,absence
R4945 T18469 T18468 nummod 4,Figure
R4946 T18470 T18471 det the,region
R4947 T18471 T18466 nsubj region,exhibits
R4948 T18013 T18011 dobj absence,ensuring
R4949 T18472 T18471 compound 2M,region
R495 T2979 T2980 det The,approach
R4950 T18473 T18471 compound donor,region
R4951 T18474 T18475 amod strong,effects
R4952 T18014 T18013 prep of,absence
R4953 T18475 T18466 dobj effects,exhibits
R4954 T18476 T18475 compound sex,effects
R4955 T18015 T18016 compound CAST,alleles
R4956 T18477 T18475 prep on,effects
R4957 T18478 T18479 det the,rate
R4958 T18016 T18014 pobj alleles,of
R4959 T18017 T18013 prep at,absence
R496 T2980 T2983 nsubj approach,is
R4960 T18018 T18017 pobj each,at
R4961 T18479 T18477 pobj rate,on
R4962 T18019 T18018 prep of,each
R4963 T18480 T18479 prep of,rate
R4964 T18481 T18482 compound lipid,storage
R4965 T18482 T18480 pobj storage,of
R4966 T18020 T18021 det these,QTL
R4967 T18483 T18466 punct ", ",exhibits
R4968 T18484 T18466 advcl dependent,exhibits
R4969 T18485 T18484 prep on,dependent
R497 T2873 T2874 det the,locus
R4970 T18021 T18019 pobj QTL,of
R4971 T18486 T18485 pobj background,on
R4972 T18487 T18466 punct .,exhibits
R4973 T18022 T17975 punct .,increased
R4974 T18489 T18490 prep In,have
R4975 T18024 T18025 det This,approach
R4976 T18491 T18492 compound control,mice
R4977 T18492 T18489 pobj mice,In
R4978 T18493 T18490 punct ", ",have
R4979 T18025 T18026 nsubjpass approach,used
R498 T2981 T2982 npadvmod speed,congenic
R4980 T18494 T18495 compound HGC,females
R4981 T18495 T18490 nsubj females,have
R4982 T18027 T18025 punct ", ",approach
R4983 T18496 T18497 det a,AI
R4984 T18497 T18490 dobj AI,have
R4985 T18498 T18497 amod higher,AI
R4986 T18499 T18497 prep than,AI
R4987 T18500 T18499 pobj males,than
R4988 T18028 T18025 acl termed,approach
R4989 T18501 T18490 punct ", ",have
R499 T2982 T2980 amod congenic,approach
R4990 T18502 T18503 mark while,seen
R4991 T18029 T18028 punct """",termed
R4992 T18503 T18490 advcl seen,have
R4993 T18504 T18505 det the,opposite
R4994 T18505 T18503 nsubjpass opposite,seen
R4995 T18030 T18031 compound QTL,Marker
R4996 T18506 T18503 auxpass is,seen
R4997 T18507 T18503 prep in,seen
R4998 T18031 T18033 npadvmod Marker,Assisted
R4999 T18508 T18509 compound B6C,mice
R500 T2984 T2985 det an,alternative
R5000 T18509 T18507 pobj mice,in
R5001 T18510 T18490 punct .,have
R5002 T18032 T18031 punct -,Marker
R5003 T18512 T18513 advmod Interestingly,abolished
R5004 T18033 T18035 amod Assisted,Selection
R5005 T18514 T18513 punct ", ",abolished
R5006 T18515 T18516 det the,QTL
R5007 T18034 T18033 punct -,Assisted
R5008 T18516 T18513 nsubj QTL,abolished
R5009 T18517 T18516 compound 2M,QTL
R501 T2874 T2872 pobj locus,outside
R5010 T18518 T18519 compound hg,modifier
R5011 T18519 T18516 compound modifier,QTL
R5012 T18035 T18028 oprd Selection,termed
R5013 T18520 T18521 det the,dimorphism
R5014 T18521 T18513 dobj dimorphism,abolished
R5015 T18522 T18523 npadvmod hg,induced
R5016 T18523 T18521 amod induced,dimorphism
R5017 T18036 T18035 compound Counter,Selection
R5018 T18037 T18035 punct """",Selection
R5019 T18524 T18521 amod sexual,dimorphism
R502 T2985 T2983 attr alternative,is
R5020 T18038 T18035 cc or,Selection
R5021 T18525 T18521 prep in,dimorphism
R5022 T18526 T18525 pobj adiposity,in
R5023 T18039 T18035 conj QMACS,Selection
R5024 T18527 T18528 punct (,Figure
R5025 T18528 T18513 parataxis Figure,abolished
R5026 T18040 T18026 punct ", ",used
R5027 T18529 T18528 nummod 4,Figure
R5028 T18530 T18528 punct ),Figure
R5029 T18531 T18513 punct .,abolished
R503 T2986 T2985 prep to,alternative
R5030 T18533 T18534 mark Although,provide
R5031 T18041 T18026 aux has,used
R5032 T18534 T18537 advcl provide,noted
R5033 T18535 T18536 det these,results
R5034 T18042 T18026 auxpass been,used
R5035 T18536 T18534 nsubj results,provide
R5036 T18043 T18026 advmod previously,used
R5037 T18538 T18534 dobj insight,provide
R5038 T18539 T18538 prep into,insight
R5039 T18540 T18541 det the,nature
R504 T2875 T2874 prep of,locus
R5040 T18044 T18045 aux to,characterize
R5041 T18541 T18539 pobj nature,into
R5042 T18542 T18541 prep of,nature
R5043 T18045 T18026 advcl characterize,used
R5044 T18543 T18544 compound hg,modifier
R5045 T18544 T18545 compound modifier,QTL
R5046 T18046 T18045 dobj QTL,characterize
R5047 T18545 T18542 pobj QTL,of
R5048 T18546 T18537 punct ", ",noted
R5049 T18547 T18537 nsubjpass it,noted
R505 T2987 T2988 det this,process
R5050 T18047 T18045 prep for,characterize
R5051 T18548 T18537 aux should,noted
R5052 T18549 T18537 auxpass be,noted
R5053 T18048 T18049 amod hypnotic,sensitivity
R5054 T18550 T18537 punct ", ",noted
R5055 T18551 T18552 mark that,is
R5056 T18552 T18537 ccomp is,noted
R5057 T18049 T18047 pobj sensitivity,for
R5058 T18553 T18554 det the,number
R5059 T18554 T18552 nsubj number,is
R506 T2988 T2986 pobj process,to
R5060 T18555 T18554 amod actual,number
R5061 T18556 T18554 cc and,number
R5062 T18557 T18558 amod precise,location
R5063 T18558 T18554 conj location,number
R5064 T18050 T18049 prep to,sensitivity
R5065 T18559 T18554 prep of,number
R5066 T18560 T18559 pobj loci,of
R5067 T18561 T18552 advmod still,is
R5068 T18051 T18050 pobj ethanol,to
R5069 T18562 T18552 acomp unclear,is
R507 T2989 T2988 amod lengthy,process
R5070 T18563 T18537 punct .,noted
R5071 T18052 T18053 punct [,31
R5072 T18565 T18566 prep In,captured
R5073 T18053 T18026 parataxis 31,used
R5074 T18567 T18565 pobj addition,In
R5075 T18054 T18053 punct ],31
R5076 T18055 T18026 punct .,used
R5077 T18057 T18058 prep In,typed
R5078 T18059 T18060 det that,study
R5079 T18060 T18057 pobj study,In
R508 T2876 T2875 pobj interest,of
R5080 T18568 T18567 prep to,addition
R5081 T18061 T18058 punct ", ",typed
R5082 T18569 T18568 pobj MMU2,to
R5083 T18570 T18566 punct ", ",captured
R5084 T18062 T18063 advmod only,markers
R5085 T18571 T18572 nummod three,congenics
R5086 T18572 T18566 nsubj congenics,captured
R5087 T18573 T18572 amod other,congenics
R5088 T18063 T18058 nsubjpass markers,typed
R5089 T18574 T18572 punct (,congenics
R509 T2990 T2983 cc and,is
R5090 T18575 T18572 appos HG9,congenics
R5091 T18064 T18063 acl flanking,markers
R5092 T18576 T18575 punct ", ",HG9
R5093 T18577 T18575 conj HG11,HG9
R5094 T18578 T18577 cc and,HG11
R5095 T18065 T18064 dobj QTL,flanking
R5096 T18579 T18577 conj HG17,HG11
R5097 T18580 T18566 punct ),captured
R5098 T18581 T18582 compound hg,modifier
R5099 T18066 T18058 auxpass were,typed
R510 T2991 T2992 aux can,reduce
R5100 T18582 T18583 compound modifier,QTL
R5101 T18583 T18566 dobj QTL,captured
R5102 T18584 T18566 punct .,captured
R5103 T18067 T18058 punct ", ",typed
R5104 T18586 T18587 prep In,are
R5105 T18068 T18069 cc not,markers
R5106 T18588 T18589 amod classical,terms
R5107 T18589 T18586 pobj terms,In
R5108 T18069 T18058 dep markers,typed
R5109 T18590 T18587 punct ", ",are
R511 T2992 T2983 conj reduce,is
R5110 T18591 T18587 nsubj they,are
R5111 T18070 T18071 npadvmod genome,wide
R5112 T18592 T18587 attr QTL,are
R5113 T18593 T18594 dep which,modify
R5114 T18594 T18592 relcl modify,QTL
R5115 T18595 T18596 det the,expressivity
R5116 T18596 T18594 dobj expressivity,modify
R5117 T18071 T18069 amod wide,markers
R5118 T18597 T18596 prep of,expressivity
R5119 T18598 T18597 pobj growth,of
R512 T2993 T2994 det the,number
R5120 T18599 T18598 cc and,growth
R5121 T18072 T18071 punct -,wide
R5122 T18600 T18598 conj obesity,growth
R5123 T18601 T18596 prep in,expressivity
R5124 T18073 T18058 punct .,typed
R5125 T18602 T18603 compound HG,mice
R5126 T18603 T18601 pobj mice,in
R5127 T18604 T18605 punct [,18
R5128 T18075 T18076 prep In,screened
R5129 T18605 T18587 parataxis 18,are
R513 T2877 T2868 cc and,eliminating
R5130 T18606 T18605 punct ],18
R5131 T18607 T18587 punct .,are
R5132 T18077 T18075 pobj contrast,In
R5133 T18609 T18610 det These,QTL
R5134 T18610 T18611 nsubj QTL,are
R5135 T18078 T18076 punct ", ",screened
R5136 T18612 T18611 acomp novel,are
R5137 T18613 T18614 mark since,represent
R5138 T18614 T18611 advcl represent,are
R5139 T18079 T18080 nsubj we,selected
R514 T2994 T2992 dobj number,reduce
R5140 T18615 T18614 nsubj they,represent
R5141 T18616 T18614 dobj epistasis,represent
R5142 T18080 T18076 ccomp selected,screened
R5143 T18617 T18616 prep between,epistasis
R5144 T18618 T18617 pobj hg,between
R5145 T18619 T18618 cc and,hg
R5146 T18081 T18080 preconj not,selected
R5147 T18620 T18621 det the,gene
R5148 T18621 T18618 conj gene,hg
R5149 T18622 T18621 compound modifier,gene
R515 T2995 T2994 prep of,number
R5150 T18082 T18081 advmod only,not
R5151 T18623 T18611 punct .,are
R5152 T18083 T18080 conj against,selected
R5153 T18625 T18626 compound QTL,hg
R5154 T18626 T18628 compound hg,epistasis
R5155 T18627 T18626 punct -,hg
R5156 T18084 T18085 amod known,QTL
R5157 T18628 T18629 nsubj epistasis,implies
R5158 T18085 T18083 pobj QTL,against
R5159 T18086 T18076 punct ", ",screened
R516 T2878 T2868 conj reducing,eliminating
R5160 T18630 T18631 mark that,are
R5161 T18631 T18629 ccomp are,implies
R5162 T18087 T18076 nsubj we,screened
R5163 T18632 T18631 nsubj Socs2,are
R5164 T18633 T18632 cc and,Socs2
R5165 T18634 T18635 det the,modifiers
R5166 T18635 T18632 conj modifiers,Socs2
R5167 T18636 T18635 compound hg,modifiers
R5168 T18088 T18076 advmod also,screened
R5169 T18637 T18631 prep in,are
R517 T2996 T2997 amod required,backcrosses
R5170 T18638 T18639 det the,pathway
R5171 T18639 T18637 pobj pathway,in
R5172 T18089 T18076 prep for,screened
R5173 T18640 T18639 amod same,pathway
R5174 T18641 T18639 amod biological,pathway
R5175 T18090 T18091 npadvmod genome,wide
R5176 T18642 T18629 punct .,implies
R5177 T18091 T18092 amod wide,heterozygosity
R5178 T18644 T18645 advmod Therefore,are
R5179 T18646 T18645 punct ", ",are
R518 T2997 T2995 pobj backcrosses,of
R5180 T18092 T18089 pobj heterozygosity,for
R5181 T18647 T18648 det these,QTL
R5182 T18648 T18645 nsubj QTL,are
R5183 T18093 T18076 advcl increasing,screened
R5184 T18649 T18645 advmod likely,are
R5185 T18650 T18645 prep due,are
R5186 T18651 T18650 pcomp to,due
R5187 T18094 T18095 det the,probability
R5188 T18652 T18650 pobj polymorphism,due
R5189 T18653 T18652 prep in,polymorphism
R519 T2998 T2992 prep from,reduce
R5190 T18654 T18653 pobj genes,in
R5191 T18095 T18093 dobj probability,increasing
R5192 T18655 T18654 acl interacting,genes
R5193 T18656 T18655 prep with,interacting
R5194 T18096 T18097 mark that,are
R5195 T18097 T18095 acl are,probability
R5196 T18098 T18097 nsubj effects,are
R5197 T18099 T18098 acl observed,effects
R5198 T18657 T18656 pobj Gh,with
R5199 T18100 T18097 prep due,are
R520 T2879 T2880 det the,variation
R5200 T18658 T18655 punct ", ",interacting
R5201 T18659 T18655 conj responsive,interacting
R5202 T18660 T18659 prep to,responsive
R5203 T18101 T18100 pcomp to,due
R5204 T18661 T18660 pobj Gh,to
R5205 T18662 T18659 cc or,responsive
R5206 T18102 T18103 amod genetic,variation
R5207 T18663 T18664 dep which,modulate
R5208 T18664 T18659 conj modulate,responsive
R5209 T18665 T18664 prep in,modulate
R521 T2999 T2998 pobj 10,from
R5210 T18836 T18837 prep In,is
R5211 T18666 T18667 det some,way
R5212 T18667 T18665 pobj way,in
R5213 T18668 T18669 compound Gh,function
R5214 T18669 T18664 dobj function,modulate
R5215 T18670 T18645 punct .,are
R5216 T18672 T18673 det This,information
R5217 T18673 T18674 nsubj information,aid
R5218 T18675 T18674 aux will,aid
R5219 T18676 T18674 advmod significantly,aid
R522 T3000 T2992 prep to,reduce
R5220 T18677 T18678 compound QTL,cloning
R5221 T18678 T18674 dobj cloning,aid
R5222 T18679 T18674 prep by,aid
R5223 T18680 T18679 pcomp providing,by
R5224 T18681 T18682 det another,filter
R5225 T18682 T18680 dobj filter,providing
R5226 T18683 T18684 aux to,screen
R5227 T18684 T18682 advcl screen,filter
R5228 T18685 T18684 dobj candidates,screen
R5229 T18686 T18674 punct .,aid
R523 T3001 T3000 pobj five,to
R5230 T18688 T18689 amod Cloning,QTL
R5231 T18689 T18691 nsubj QTL,has
R5232 T18690 T18689 det these,QTL
R5233 T18692 T18693 amod major,implications
R5234 T18693 T18691 dobj implications,has
R5235 T18694 T18695 aux to,improve
R5236 T18695 T18693 advcl improve,implications
R5237 T18696 T18697 poss our,understanding
R5238 T18838 T18836 pobj contrast,In
R5239 T18697 T18695 dobj understanding,improve
R524 T2880 T2878 dobj variation,reducing
R5240 T18698 T18697 prep of,understanding
R5241 T18699 T18698 pobj Gh,of
R5242 T18700 T18699 cc and,Gh
R5243 T18701 T18702 poss its,regulation
R5244 T18702 T18699 conj regulation,Gh
R5245 T18839 T18837 punct ", ",is
R5246 T18703 T18702 prep of,regulation
R5247 T18704 T18703 pobj growth,of
R5248 T18840 T18841 det the,strain
R5249 T18705 T18704 cc and,growth
R525 T3002 T3003 punct [,6
R5250 T18706 T18704 conj adiposity,growth
R5251 T18707 T18695 cc and,improve
R5252 T18841 T18837 nsubj strain,is
R5253 T18708 T18695 conj in,improve
R5254 T18709 T18710 det the,administration
R5255 T18842 T18841 compound HG9,strain
R5256 T18710 T18708 pobj administration,in
R5257 T18711 T18710 prep of,administration
R5258 T18712 T18713 amod human,Gh
R5259 T18843 T18844 det an,model
R526 T3003 T2992 parataxis 6,reduce
R5260 T18713 T18714 compound Gh,therapeutics
R5261 T18714 T18711 pobj therapeutics,of
R5262 T18715 T18691 punct .,has
R5263 T18844 T18837 attr model,is
R5264 T18717 T18718 compound HG1,mice
R5265 T18845 T18846 amod obese,mouse
R5266 T18718 T18719 nsubj mice,displayed
R5267 T18720 T18719 dobj differences,displayed
R5268 T18846 T18844 compound mouse,model
R5269 T18721 T18722 advmod only,in
R527 T3004 T3003 nummod 5,6
R5270 T18722 T18720 prep in,differences
R5271 T18723 T18724 compound growth,traits
R5272 T18724 T18722 pobj traits,in
R5273 T18725 T18719 punct .,displayed
R5274 T18847 T18837 punct .,is
R5275 T18727 T18728 advmod Originally,had
R5276 T18849 T18850 det The,strain
R5277 T18729 T18728 punct ", ",had
R5278 T18730 T18728 nsubj Q1Ucd1,had
R5279 T18731 T18732 amod small,effects
R528 T2881 T2880 amod environmental,variation
R5280 T18732 T18728 dobj effects,had
R5281 T18850 T18851 nsubj strain,is
R5282 T18733 T18728 cc and,had
R5283 T18734 T18735 det these,results
R5284 T18852 T18853 advmod quite,novel
R5285 T18735 T18736 nsubj results,illustrate
R5286 T18853 T18851 acomp novel,is
R5287 T18736 T18728 conj illustrate,had
R5288 T18854 T18851 prep for,is
R5289 T18737 T18738 det the,power
R529 T3005 T3003 punct ",",6
R5290 T18738 T18736 dobj power,illustrate
R5291 T18739 T18738 prep of,power
R5292 T18740 T18741 amod congenic,strain
R5293 T18855 T18856 nummod two,reasons
R5294 T18856 T18854 pobj reasons,for
R5295 T18857 T18851 punct .,is
R5296 T18741 T18742 compound strain,analysis
R5297 T18859 T18860 advmod First,was
R5298 T18742 T18739 pobj analysis,of
R5299 T18743 T18744 aux to,isolate
R530 T3006 T3003 punct ],6
R5300 T18861 T18860 punct ", ",was
R5301 T18744 T18738 acl isolate,power
R5302 T18745 T18746 amod small,effect
R5303 T18862 T18863 det the,size
R5304 T18863 T18865 nsubj size,is
R5305 T18864 T18863 compound effect,size
R5306 T18865 T18860 ccomp is,was
R5307 T18746 T18747 compound effect,QTL
R5308 T18866 T18865 acomp large,is
R5309 T18747 T18744 dobj QTL,isolate
R531 T3007 T2983 punct .,is
R5310 T18867 T18860 punct ;,was
R5311 T18748 T18736 punct ", ",illustrate
R5312 T18749 T18750 mark although,is
R5313 T18750 T18736 advcl is,illustrate
R5314 T18868 T18860 nsubj AI,was
R5315 T18751 T18750 nsubj it,is
R5316 T18752 T18750 acomp likely,is
R5317 T18869 T18870 nummod 57,%
R5318 T18753 T18754 det this,QTL
R5319 T18754 T18755 nsubj QTL,represents
R532 T2882 T2880 acl influencing,variation
R5320 T18755 T18752 advcl represents,likely
R5321 T18756 T18757 det the,boundary
R5322 T18757 T18755 dobj boundary,represents
R5323 T18870 T18871 npadvmod %,higher
R5324 T18758 T18757 amod lower,boundary
R5325 T18759 T18757 prep of,boundary
R5326 T18760 T18759 pobj detection,of
R5327 T18871 T18860 acomp higher,was
R5328 T18761 T18757 acl using,boundary
R5329 T18762 T18763 advmod only,30
R533 T2883 T2884 det a,trait
R5330 T18872 T18871 prep in,higher
R5331 T18763 T18766 nummod 30,mice
R5332 T18764 T18763 quantmod 20,30
R5333 T18765 T18763 punct –,30
R5334 T18873 T18874 compound HG9,females
R5335 T18766 T18761 dobj mice,using
R5336 T18767 T18766 amod congenic,mice
R5337 T18768 T18736 punct .,illustrate
R5338 T18874 T18872 pobj females,in
R5339 T18770 T18771 det The,genes
R534 T2884 T2882 dobj trait,influencing
R5340 T18771 T18775 nsubj genes,are
R5341 T18875 T18871 cc and,higher
R5342 T18772 T18773 advmod most,notable
R5343 T18773 T18771 amod notable,genes
R5344 T18774 T18771 compound candidate,genes
R5345 T18876 T18877 nummod 30,%
R5346 T18776 T18771 acl located,genes
R5347 T18877 T18878 npadvmod %,higher
R5348 T18777 T18776 prep within,located
R5349 T18778 T18779 det the,interval
R535 T3009 T3010 det This,strategy
R5350 T18878 T18871 conj higher,higher
R5351 T18779 T18777 pobj interval,within
R5352 T18780 T18779 compound HG1,interval
R5353 T18879 T18878 prep in,higher
R5354 T18781 T18782 det the,transducer
R5355 T18782 T18775 attr transducer,are
R5356 T18783 T18782 compound signal,transducer
R5357 T18880 T18879 pobj males,in
R5358 T18784 T18782 cc and,transducer
R5359 T18785 T18782 conj activator,transducer
R536 T2885 T2878 prep by,reducing
R5360 T18881 T18860 punct .,was
R5361 T18786 T18785 prep of,activator
R5362 T18787 T18786 pobj transcription,of
R5363 T18788 T18787 nummod 1,transcription
R5364 T18883 T18884 advmod Secondly,is
R5365 T18789 T18787 punct (,transcription
R5366 T18790 T18787 appos Stat1,transcription
R5367 T18791 T18787 punct ),transcription
R5368 T18885 T18884 punct ", ",is
R5369 T18792 T18787 cc and,transcription
R537 T3010 T3011 nsubj strategy,uses
R5370 T18793 T18787 conj Stat4,transcription
R5371 T18794 T18775 punct .,are
R5372 T18886 T18884 nsubj it,is
R5373 T18796 T18797 nsubj Two,had
R5374 T18798 T18796 prep of,Two
R5375 T18799 T18800 det the,congenics
R5376 T18800 T18798 pobj congenics,of
R5377 T18887 T18884 acomp dependent,is
R5378 T18801 T18802 amod major,alterations
R5379 T18802 T18797 dative alterations,had
R538 T3012 T3013 npadvmod marker,assisted
R5380 T18888 T18887 prep on,dependent
R5381 T18803 T18802 prep in,alterations
R5382 T18804 T18805 det the,deposition
R5383 T18805 T18803 pobj deposition,in
R5384 T18889 T18888 pobj hg,on
R5385 T18806 T18805 prep of,deposition
R5386 T18807 T18808 compound adipose,tissue
R5387 T18808 T18806 pobj tissue,of
R5388 T18890 T18884 prep for,is
R5389 T18809 T18797 punct ", ",had
R539 T3013 T3015 amod assisted,selection
R5390 T18810 T18797 dobj HG8,had
R5391 T18811 T18810 cc and,HG8
R5392 T18891 T18892 poss its,expression
R5393 T18812 T18810 conj HG9,HG8
R5394 T18813 T18797 punct .,had
R5395 T18892 T18890 pobj expression,for
R5396 T18815 T18816 det The,region
R5397 T18893 T18884 punct .,is
R5398 T18816 T18819 nsubj region,promotes
R5399 T18817 T18816 compound HG8,region
R540 T3014 T3013 punct -,assisted
R5400 T18895 T18896 det The,strain
R5401 T18818 T18816 compound donor,region
R5402 T18820 T18819 dobj leanness,promotes
R5403 T18821 T18819 punct .,promotes
R5404 T18896 T18898 nsubj strain,represents
R5405 T18823 T18824 amod Congenic,females
R5406 T18897 T18896 compound HG9,strain
R5407 T18824 T18825 nsubj females,displayed
R5408 T18826 T18827 det a,reduction
R5409 T18899 T18900 det a,model
R541 T3015 T3011 dobj selection,uses
R5410 T18827 T18825 dobj reduction,displayed
R5411 T18828 T18827 prep of,reduction
R5412 T18829 T18830 quantmod over,25
R5413 T18900 T18898 dobj model,represents
R5414 T18830 T18831 nummod 25,%
R5415 T18831 T18828 pobj %,of
R5416 T18901 T18900 amod major,model
R5417 T18832 T18827 prep in,reduction
R5418 T18833 T18832 pobj AI,in
R5419 T18834 T18825 punct .,displayed
R542 T2886 T2885 pcomp characterizing,by
R5420 T18902 T18903 npadvmod epistasis,based
R5421 T18903 T18900 amod based,model
R5422 T18904 T18903 punct -,based
R5423 T18905 T18906 amod obese,mouse
R5424 T18906 T18900 compound mouse,model
R5425 T18907 T18898 cc and,represents
R5426 T18908 T18898 conj promises,represents
R5427 T18909 T18910 aux to,aid
R5428 T18910 T18908 xcomp aid,promises
R5429 T18911 T18910 prep in,aid
R543 T3016 T3017 aux to,identify
R5430 T18912 T18913 det the,understanding
R5431 T18913 T18911 pobj understanding,in
R5432 T18914 T18913 prep of,understanding
R5433 T18915 T18914 pobj obesity,of
R5434 T19201 T19202 npadvmod sex,specific
R5435 T18916 T18913 cc and,understanding
R5436 T19202 T19200 amod specific,phenotypes
R5437 T19203 T19202 punct -,specific
R5438 T18917 T18918 advmod specifically,modulation
R5439 T19204 T19200 prep in,phenotypes
R544 T3017 T3011 advcl identify,uses
R5440 T19205 T19206 compound HG11,mice
R5441 T19206 T19204 pobj mice,in
R5442 T18918 T18913 conj modulation,understanding
R5443 T19207 T19208 mark since,is
R5444 T19208 T19192 advcl is,explain
R5445 T18919 T18918 det the,modulation
R5446 T19209 T19208 nsubj it,is
R5447 T19210 T19211 det the,factor
R5448 T19211 T19208 attr factor,is
R5449 T18920 T18918 prep of,modulation
R545 T3018 T3019 amod male,mice
R5450 T19212 T19211 amod primary,factor
R5451 T19213 T19211 compound transcription,factor
R5452 T19214 T19211 amod responsible,factor
R5453 T18921 T18922 compound adipose,tissue
R5454 T19215 T19214 prep for,responsible
R5455 T19216 T19217 npadvmod Gh,induced
R5456 T19217 T19218 amod induced,expression
R5457 T18922 T18923 compound tissue,deposition
R5458 T19218 T19215 pobj expression,for
R5459 T19219 T19220 npadvmod sex,specific
R546 T2887 T2888 amod large,numbers
R5460 T19220 T19218 amod specific,expression
R5461 T18923 T18920 pobj deposition,of
R5462 T19221 T19220 punct -,specific
R5463 T19222 T19223 compound liver,gene
R5464 T18924 T18918 prep by,modulation
R5465 T19223 T19218 compound gene,expression
R5466 T19224 T19225 punct [,44
R5467 T19225 T19192 parataxis 44,explain
R5468 T18925 T18924 pobj Gh,by
R5469 T19226 T19225 punct ],44
R547 T3019 T3017 dobj mice,identify
R5470 T19227 T19192 punct .,explain
R5471 T18926 T18898 punct .,represents
R5472 T19229 T19230 amod Future,studies
R5473 T19230 T19231 nsubj studies,include
R5474 T19232 T19230 acl aimed,studies
R5475 T19233 T19232 prep at,aimed
R5476 T19234 T19233 pcomp identifying,at
R5477 T19235 T19236 det the,QTG
R5478 T19236 T19234 dobj QTG,identifying
R5479 T19237 T19236 compound HG11,QTG
R548 T2888 T2886 dobj numbers,characterizing
R5480 T19238 T19231 punct ", ",include
R5481 T19239 T19231 aux will,include
R5482 T19240 T19231 advmod certainly,include
R5483 T19241 T19242 det a,characterization
R5484 T18928 T18929 nsubj Studies,are
R5485 T19242 T19231 dobj characterization,include
R5486 T19243 T19242 amod thorough,characterization
R5487 T19244 T19242 prep of,characterization
R5488 T19245 T19246 nmod Gh,patterns
R5489 T18930 T18929 advmod currently,are
R549 T3020 T3019 acl inheriting,mice
R5490 T19246 T19244 pobj patterns,of
R5491 T19247 T19245 cc and,Gh
R5492 T19248 T19245 conj Stat5b,Gh
R5493 T19249 T19246 nmod sequence,patterns
R5494 T18931 T18929 acomp underway,are
R5495 T19250 T19249 cc and,sequence
R5496 T19251 T19249 conj expression,sequence
R5497 T18932 T18933 aux to,identify
R5498 T19252 T19246 prep in,patterns
R5499 T19253 T19254 amod congenic,mice
R550 T3021 T3022 amod fewer,alleles
R5500 T19254 T19252 pobj mice,in
R5501 T18933 T18929 advcl identify,are
R5502 T19255 T19231 punct .,include
R5503 T18934 T18935 det the,mutation
R5504 T19257 T19258 det The,QTL
R5505 T19258 T19261 nsubj QTL,had
R5506 T19259 T19260 compound hg,modifier
R5507 T18935 T18933 dobj mutation,identify
R5508 T19260 T19258 compound modifier,QTL
R5509 T19262 T19258 acl located,QTL
R551 T2889 T2888 prep of,numbers
R5510 T18936 T18935 amod causative,mutation
R5511 T19263 T19262 prep within,located
R5512 T19264 T19265 det the,strain
R5513 T19265 T19263 pobj strain,within
R5514 T18937 T18933 cc and,identify
R5515 T18938 T18939 aux to,characterize
R5516 T19266 T19265 compound HG17,strain
R5517 T18939 T18933 conj characterize,identify
R5518 T19267 T19268 amod large,effects
R5519 T19268 T19261 dobj effects,had
R552 T2890 T2891 advmod genetically,identical
R5520 T18940 T18941 det the,effects
R5521 T19269 T19268 prep on,effects
R5522 T19270 T19269 pobj growth,on
R5523 T19271 T19270 punct ", ",growth
R5524 T18941 T18939 dobj effects,characterize
R5525 T19272 T19273 compound body,length
R5526 T19273 T19270 conj length,growth
R5527 T18942 T18941 prep of,effects
R5528 T19274 T19273 cc and,length
R5529 T19275 T19276 compound carcass,components
R553 T3022 T3020 dobj alleles,inheriting
R5530 T18943 T18942 pobj age,of
R5531 T18944 T18943 cc and,age
R5532 T18945 T18943 conj diet,age
R5533 T19276 T19273 conj components,length
R5534 T18946 T18941 prep on,effects
R5535 T19277 T19261 punct .,had
R5536 T18947 T18946 pobj obesity,on
R5537 T19279 T19280 det The,gene
R5538 T18948 T18947 prep in,obesity
R5539 T19280 T19284 nsubj gene,is
R554 T3023 T3022 compound donor,alleles
R5540 T19281 T19282 advmod most,intriguing
R5541 T19282 T19280 amod intriguing,gene
R5542 T18949 T18950 det this,strain
R5543 T19283 T19280 compound candidate,gene
R5544 T18950 T18948 pobj strain,in
R5545 T19285 T19280 acl located,gene
R5546 T19286 T19285 prep in,located
R5547 T19287 T19288 det the,congenic
R5548 T18951 T18952 advmod as,as
R5549 T19288 T19286 pobj congenic,in
R555 T2891 T2892 amod identical,mice
R5550 T19289 T19284 attr Sstr5,is
R5551 T19290 T19284 punct .,is
R5552 T18952 T18941 cc as,effects
R5553 T19292 T19293 nsubj Somatostatin,is
R5554 T18953 T18952 advmod well,as
R5555 T19294 T19295 det a,inhibitor
R5556 T18954 T18941 conj testing,effects
R5557 T19295 T19293 attr inhibitor,is
R5558 T19296 T19295 amod potent,inhibitor
R5559 T18955 T18954 prep for,testing
R556 T3024 T3022 punct ", ",alleles
R5560 T19297 T19295 prep of,inhibitor
R5561 T19298 T19297 pobj Gh,of
R5562 T19299 T19293 cc and,is
R5563 T18956 T18957 amod other,consequences
R5564 T19300 T19301 nsubj Sstr5,is
R5565 T19301 T19293 conj is,is
R5566 T19302 T19301 attr one,is
R5567 T18957 T18955 pobj consequences,for
R5568 T19303 T19302 prep of,one
R5569 T19304 T19305 nummod five,receptors
R557 T3025 T3026 mark than,expected
R5570 T18958 T18957 amod physiological,consequences
R5571 T19305 T19303 pobj receptors,of
R5572 T19306 T19307 dep which,mediate
R5573 T19307 T19305 relcl mediate,receptors
R5574 T18959 T18960 amod such,as
R5575 T19308 T19309 det these,effects
R5576 T19309 T19307 dobj effects,mediate
R5577 T18960 T18957 prep as,consequences
R5578 T19310 T19311 punct [,46
R5579 T19311 T19301 parataxis 46,is
R558 T3026 T3022 advcl expected,alleles
R5580 T19312 T19311 nummod 45,46
R5581 T19313 T19311 punct ",",46
R5582 T19314 T19311 punct ],46
R5583 T19315 T19301 punct .,is
R5584 T18961 T18960 pobj alterations,as
R5585 T19317 T19318 amod Ubiquitous,knockout
R5586 T18962 T18961 prep in,alterations
R5587 T19318 T19324 nsubj knockout,leads
R5588 T19319 T19317 cc and,Ubiquitous
R5589 T19320 T19321 amod pancreatic,cell
R559 T2892 T2889 pobj mice,of
R5590 T18963 T18964 compound food,intake
R5591 T19321 T19323 npadvmod cell,specific
R5592 T19322 T19321 compound beta,cell
R5593 T19323 T19317 conj specific,Ubiquitous
R5594 T18964 T18962 pobj intake,in
R5595 T19325 T19318 prep of,knockout
R5596 T19326 T19325 pobj Sstr5,of
R5597 T18965 T18964 cc and,intake
R5598 T19327 T19324 prep to,leads
R5599 T19328 T19327 pobj alterations,to
R560 T3027 T3020 prep on,inheriting
R5600 T18966 T18967 compound insulin,sensitivity
R5601 T19329 T19328 prep in,alterations
R5602 T19330 T19331 compound insulin,secretion
R5603 T19331 T19329 pobj secretion,in
R5604 T18967 T18964 conj sensitivity,intake
R5605 T19332 T19331 cc and,secretion
R5606 T19333 T19334 compound glucose,homeostasis
R5607 T18968 T18929 punct .,are
R5608 T19334 T19331 conj homeostasis,secretion
R5609 T19335 T19336 punct [,48
R561 T3028 T3027 amod average,on
R5610 T19336 T19324 parataxis 48,leads
R5611 T18970 T18971 det The,strain
R5612 T19337 T19336 nummod 47,48
R5613 T19338 T19336 punct ",",48
R5614 T19339 T19336 punct ],48
R5615 T19340 T19324 punct .,leads
R5616 T18971 T18973 nsubj strain,is
R5617 T19342 T19343 nsubj We,sequenced
R5618 T18972 T18971 compound HG11,strain
R5619 T19344 T19345 compound candidate,genes
R562 T3029 T3011 punct ", ",uses
R5620 T19345 T19343 dobj genes,sequenced
R5621 T18974 T18973 prep of,is
R5622 T19346 T19347 compound hg,modifier
R5623 T19347 T19345 compound modifier,genes
R5624 T19348 T19349 aux to,complement
R5625 T19349 T19343 advcl complement,sequenced
R5626 T18975 T18976 amod particular,interest
R5627 T19350 T19351 det the,characterization
R5628 T19351 T19349 dobj characterization,complement
R5629 T18976 T18974 pobj interest,of
R563 T2893 T2865 punct .,accomplished
R5630 T19352 T19351 prep of,characterization
R5631 T19353 T19354 det the,congenics
R5632 T19354 T19352 pobj congenics,of
R5633 T19355 T19354 compound speed,congenics
R5634 T19356 T19354 prep on,congenics
R5635 T19357 T19358 nmod MMU,2
R5636 T18977 T18973 prep for,is
R5637 T19358 T19356 pobj 2,on
R5638 T19359 T19358 punct ", ",2
R5639 T19360 T19358 conj 9,2
R564 T3030 T3011 prep during,uses
R5640 T18978 T18979 det a,number
R5641 T19361 T19360 punct ", ",9
R5642 T19362 T19360 conj 11,9
R5643 T18979 T18977 pobj number,for
R5644 T19363 T19362 cc and,11
R5645 T19364 T19362 conj 17,11
R5646 T18980 T18979 prep of,number
R5647 T18981 T18980 pobj reasons,of
R5648 T18982 T18973 punct .,is
R5649 T18984 T18985 advmod First,demonstrated
R565 T3031 T3032 det each,backcross
R5650 T19365 T19343 punct .,sequenced
R5651 T18986 T18985 punct ", ",demonstrated
R5652 T19367 T19368 det A,number
R5653 T19368 T19370 nsubj number,identified
R5654 T19369 T19368 amod limited,number
R5655 T18987 T18988 npadvmod HG11,congenic
R5656 T19371 T19368 prep of,number
R5657 T18988 T18989 amod congenic,mice
R5658 T18989 T18985 nsubj mice,demonstrated
R5659 T19372 T19371 pobj studies,of
R566 T2895 T2896 det The,Consortium
R5660 T19373 T19370 aux have,identified
R5661 T18990 T18991 amod significant,interactions
R5662 T19374 T19370 dobj variation,identified
R5663 T19375 T19374 prep within,variation
R5664 T18991 T18985 dobj interactions,demonstrated
R5665 T19376 T19377 compound CAST,sequence
R5666 T19377 T19375 pobj sequence,within
R5667 T19378 T19377 compound coding,sequence
R5668 T18992 T18991 nmod strain,interactions
R5669 T19379 T19370 punct ;,identified
R567 T3032 T3030 pobj backcross,during
R5670 T19380 T19370 cc so,identified
R5671 T18993 T18992 prep by,strain
R5672 T19381 T19382 amod sequencing,candidates
R5673 T19382 T19383 nsubj candidates,gave
R5674 T19383 T19370 conj gave,identified
R5675 T18994 T18993 pobj sex,by
R5676 T19384 T19383 dative us,gave
R5677 T19385 T19386 det the,opportunity
R5678 T18995 T18985 prep for,demonstrated
R5679 T19386 T19383 dobj opportunity,gave
R568 T3033 T3011 punct .,uses
R5680 T19387 T19388 aux to,estimate
R5681 T18996 T18997 det a,number
R5682 T19388 T19386 acl estimate,opportunity
R5683 T19389 T19390 det the,frequency
R5684 T19390 T19388 dobj frequency,estimate
R5685 T19391 T19390 compound SNP,frequency
R5686 T19392 T19390 prep in,frequency
R5687 T18997 T18995 pobj number,for
R5688 T19393 T19394 compound coding,sequence
R5689 T19394 T19392 pobj sequence,in
R569 T2896 T2899 nsubj Consortium,considers
R5690 T19395 T19388 advcl relative,estimate
R5691 T18998 T18997 prep of,number
R5692 T19396 T19395 prep to,relative
R5693 T19397 T19396 pobj B6,to
R5694 T19398 T19383 punct .,gave
R5695 T18999 T18998 pobj traits,of
R5696 T19400 T19401 det This,information
R5697 T19000 T18985 punct .,demonstrated
R5698 T19401 T19402 nsubj information,be
R5699 T19403 T19402 aux will,be
R570 T3035 T3036 amod Numerous,congenics
R5700 T19002 T19003 nsubj Males,were
R5701 T19404 T19402 acomp vital,be
R5702 T19405 T19404 prep to,vital
R5703 T19406 T19407 amod future,studies
R5704 T19004 T19005 advmod generally,larger
R5705 T19407 T19405 pobj studies,to
R5706 T19408 T19409 amod fine,mapping
R5707 T19409 T19407 compound mapping,studies
R5708 T19410 T19407 punct ", ",studies
R5709 T19005 T19003 acomp larger,were
R571 T3036 T3041 nsubjpass congenics,used
R5710 T19411 T19412 dep which,include
R5711 T19412 T19407 relcl include,studies
R5712 T19413 T19412 aux will,include
R5713 T19006 T19005 punct ", ",larger
R5714 T19414 T19415 compound gene,expression
R5715 T19415 T19416 compound expression,analysis
R5716 T19416 T19412 dobj analysis,include
R5717 T19007 T19008 amod faster,growing
R5718 T19417 T19402 punct .,be
R5719 T19008 T19005 conj growing,larger
R572 T3037 T3038 advmod traditionally,developed
R5720 T19419 T19420 det The,frequency
R5721 T19420 T19423 nsubj frequency,lead
R5722 T19421 T19420 amod high,frequency
R5723 T19009 T19008 cc and,growing
R5724 T19422 T19420 compound SNP,frequency
R5725 T19424 T19425 punct (,SNP
R5726 T19010 T19008 conj longer,growing
R5727 T19425 T19420 parataxis SNP,frequency
R5728 T19426 T19427 nummod 0.312,%
R5729 T19427 T19425 dep %,SNP
R573 T2897 T2898 compound Complex,Trait
R5730 T19011 T19003 cc and,were
R5731 T19428 T19425 punct ;,SNP
R5732 T19429 T19425 nummod 295,SNP
R5733 T19012 T19013 det the,converse
R5734 T19430 T19425 prep in,SNP
R5735 T19431 T19432 nummod 94.492,kbp
R5736 T19432 T19430 pobj kbp,in
R5737 T19433 T19425 punct ),SNP
R5738 T19434 T19420 prep in,frequency
R5739 T19435 T19436 compound CAST,genes
R574 T3038 T3036 amod developed,congenics
R5740 T19013 T19014 nsubjpass converse,seen
R5741 T19436 T19434 pobj genes,in
R5742 T19437 T19423 aux may,lead
R5743 T19438 T19423 prep to,lead
R5744 T19014 T19003 conj seen,were
R5745 T19439 T19440 det a,rate
R5746 T19440 T19438 pobj rate,to
R5747 T19441 T19440 amod higher,rate
R5748 T19442 T19440 prep of,rate
R5749 T19443 T19444 amod false,positives
R575 T3039 T3038 cc and,developed
R5750 T19444 T19442 pobj positives,of
R5751 T19445 T19444 acl using,positives
R5752 T19446 T19447 compound DNA,microarrays
R5753 T19447 T19445 dobj microarrays,using
R5754 T19448 T19447 cc or,microarrays
R5755 T19015 T19014 auxpass was,seen
R5756 T19449 T19450 amod quantitative,assays
R5757 T19016 T19014 prep in,seen
R5758 T19017 T19016 pobj females,in
R5759 T19018 T19014 punct .,seen
R576 T3040 T3038 conj speed,developed
R5760 T19020 T19021 det The,effects
R5761 T19450 T19447 conj assays,microarrays
R5762 T19021 T19023 nsubj effects,are
R5763 T19451 T19452 amod real,time
R5764 T19452 T19450 compound time,assays
R5765 T19453 T19452 punct -,time
R5766 T19022 T19021 amod confounding,effects
R5767 T19454 T19450 compound PCR,assays
R5768 T19455 T19447 punct ", ",microarrays
R5769 T19024 T19021 prep of,effects
R577 T2898 T2896 compound Trait,Consortium
R5770 T19456 T19457 dep most,based
R5771 T19457 T19447 relcl based,microarrays
R5772 T19458 T19456 prep of,most
R5773 T19459 T19458 pobj which,of
R5774 T19025 T19024 pobj sex,of
R5775 T19460 T19457 auxpass are,based
R5776 T19461 T19457 prep on,based
R5777 T19462 T19463 compound B6,sequence
R5778 T19026 T19023 advmod likely,are
R5779 T19463 T19461 pobj sequence,on
R578 T3042 T3041 aux have,used
R5780 T19464 T19423 punct .,lead
R5781 T19027 T19028 det the,reason
R5782 T19466 T19467 advmod Therefore,used
R5783 T19028 T19023 attr reason,are
R5784 T19468 T19467 punct ", ",used
R5785 T19469 T19470 det these,data
R5786 T19470 T19467 nsubjpass data,used
R5787 T19029 T19028 prep for,reason
R5788 T19471 T19470 compound sequence,data
R5789 T19472 T19467 aux can,used
R579 T3043 T3041 auxpass been,used
R5790 T19473 T19467 auxpass be,used
R5791 T19474 T19475 aux to,guide
R5792 T19475 T19467 advcl guide,used
R5793 T19476 T19477 det the,development
R5794 T19030 T19031 det the,discrepancies
R5795 T19477 T19475 dobj development,guide
R5796 T19031 T19029 pobj discrepancies,for
R5797 T19032 T19031 prep between,discrepancies
R5798 T19478 T19477 prep of,development
R5799 T19479 T19480 compound gene,expression
R580 T2900 T2896 punct (,Consortium
R5800 T19480 T19481 compound expression,assays
R5801 T19033 T19034 det the,results
R5802 T19481 T19478 pobj assays,of
R5803 T19482 T19483 aux to,confirm
R5804 T19034 T19032 pobj results,between
R5805 T19483 T19475 advcl confirm,guide
R5806 T19484 T19485 amod differential,expression
R5807 T19485 T19483 dobj expression,confirm
R5808 T19035 T19036 amod congenic,genome
R5809 T19486 T19483 prep for,confirm
R581 T3044 T3045 aux to,isolate
R5810 T19487 T19486 pobj candidates,for
R5811 T19036 T19038 compound genome,scan
R5812 T19488 T19467 cc and,used
R5813 T19489 T19467 conj suggests,used
R5814 T19037 T19036 cc and,genome
R5815 T19490 T19491 mark that,sequenced
R5816 T19491 T19489 ccomp sequenced,suggests
R5817 T19492 T19491 nsubjpass genes,sequenced
R5818 T19493 T19492 acl identified,genes
R5819 T19038 T19034 compound scan,results
R582 T3045 T3041 advcl isolate,used
R5820 T19494 T19493 prep by,identified
R5821 T19495 T19496 amod downstream,experiments
R5822 T19039 T19034 punct ", ",results
R5823 T19496 T19494 pobj experiments,by
R5824 T19497 T19491 aux should,sequenced
R5825 T19498 T19491 advmod also,sequenced
R5826 T19040 T19041 advmod where,analyzed
R5827 T19499 T19491 auxpass be,sequenced
R5828 T19500 T19467 punct .,used
R5829 T19041 T19034 relcl analyzed,results
R583 T3046 T3045 advmod successfully,isolate
R5830 T19502 T19503 advmod More,importantly
R5831 T19503 T19504 advmod importantly,allowed
R5832 T19042 T19043 det both,sexes
R5833 T19505 T19504 punct ", ",allowed
R5834 T19506 T19504 csubj sequencing,allowed
R5835 T19043 T19041 nsubjpass sexes,analyzed
R5836 T19507 T19508 compound hg,modifier
R5837 T19508 T19509 compound modifier,candidates
R5838 T19509 T19506 dobj candidates,sequencing
R5839 T19044 T19041 auxpass were,analyzed
R584 T3047 T3048 compound mouse,QTL
R5840 T19510 T19511 nsubj us,identify
R5841 T19511 T19504 ccomp identify,allowed
R5842 T19512 T19511 aux to,identify
R5843 T19513 T19514 amod nonsynonomous,polymorphism
R5844 T19514 T19511 dobj polymorphism,identify
R5845 T19515 T19514 punct ", ",polymorphism
R5846 T19045 T19041 advmod together,analyzed
R5847 T19516 T19517 dep which,underlie
R5848 T19517 T19514 relcl underlie,polymorphism
R5849 T19518 T19517 aux may,underlie
R585 T2901 T2896 appos CTC,Consortium
R5850 T19046 T19023 punct .,are
R5851 T19519 T19517 dobj QTL,underlie
R5852 T19520 T19504 punct .,allowed
R5853 T19048 T19049 advmod Secondly,found
R5854 T19522 T19523 nsubj SIFT,predicted
R5855 T19524 T19522 cc and,SIFT
R5856 T19525 T19524 punct /,and
R5857 T19050 T19049 punct ", ",found
R5858 T19526 T19524 cc or,and
R5859 T19527 T19522 conj PolyPhen,SIFT
R586 T3048 T3045 dobj QTL,isolate
R5860 T19528 T19523 dobj alterations,predicted
R5861 T19529 T19528 prep in,alterations
R5862 T19051 T19049 nsubjpass Carp2,found
R5863 T19530 T19531 compound protein,function
R5864 T19531 T19529 pobj function,in
R5865 T19052 T19049 auxpass was,found
R5866 T19532 T19528 prep for,alterations
R5867 T19533 T19532 pobj 15,for
R5868 T19534 T19533 prep of,15
R5869 T19053 T19054 aux to,interact
R587 T3049 T3045 prep for,isolate
R5870 T19535 T19536 det the,nsSNP
R5871 T19536 T19534 pobj nsSNP,of
R5872 T19054 T19049 xcomp interact,found
R5873 T19055 T19054 prep with,interact
R5874 T19056 T19055 pobj hg,with
R5875 T19057 T19049 cc and,found
R5876 T19058 T19059 nsubjpass MMU11,saturated
R5877 T19537 T19536 nummod 56,nsSNP
R5878 T19538 T19536 amod total,nsSNP
R5879 T19059 T19049 conj saturated,found
R588 T2902 T2899 punct ),considers
R5880 T19060 T19059 auxpass is,saturated
R5881 T19061 T19059 prep with,saturated
R5882 T19062 T19061 pobj genes,with
R5883 T19063 T19062 acl involved,genes
R5884 T19539 T19540 punct (,%
R5885 T19064 T19063 prep in,involved
R5886 T19540 T19533 parataxis %,15
R5887 T19541 T19540 nummod 27,%
R5888 T19065 T19066 det the,pathway
R5889 T19542 T19540 punct ),%
R589 T3050 T3051 det a,array
R5890 T19543 T19533 prep in,15
R5891 T19066 T19064 pobj pathway,in
R5892 T19544 T19543 pobj nine,in
R5893 T19545 T19544 prep of,nine
R5894 T19546 T19547 det the,genes
R5895 T19547 T19545 pobj genes,of
R5896 T19548 T19547 nummod 44,genes
R5897 T19067 T19066 amod central,pathway
R5898 T19549 T19547 amod total,genes
R5899 T19550 T19551 punct (,%
R590 T3051 T3049 pobj array,for
R5900 T19551 T19543 parataxis %,in
R5901 T19068 T19066 nmod Gh,pathway
R5902 T19552 T19551 nummod 20,%
R5903 T19553 T19551 punct ),%
R5904 T19069 T19066 amod intracellular,pathway
R5905 T19554 T19555 punct (,Table
R5906 T19555 T19523 parataxis Table,predicted
R5907 T19556 T19555 nummod 7,Table
R5908 T19070 T19066 compound signaling,pathway
R5909 T19557 T19555 punct ),Table
R591 T3052 T3051 amod wide,array
R5910 T19558 T19523 punct .,predicted
R5911 T19071 T19062 punct ", ",genes
R5912 T19560 T19561 nsubjpass It,shown
R5913 T19072 T19073 amod such,as
R5914 T19562 T19561 aux has,shown
R5915 T19563 T19561 auxpass been,shown
R5916 T19073 T19062 prep as,genes
R5917 T19564 T19565 mark that,is
R5918 T19565 T19561 ccomp is,shown
R5919 T19566 T19565 csubj predicting,is
R592 T3053 T3051 prep of,array
R5920 T19074 T19073 pobj Gh,as
R5921 T19075 T19074 punct ", ",Gh
R5922 T19076 T19074 conj Stat5b,Gh
R5923 T19077 T19076 cc and,Stat5b
R5924 T19567 T19566 dobj function,predicting
R5925 T19568 T19566 prep based,predicting
R5926 T19078 T19076 conj Stat5a,Stat5b
R5927 T19569 T19568 prep on,based
R5928 T19570 T19571 amod evolutionary,conservation
R5929 T19571 T19569 pobj conservation,on
R593 T3054 T3053 pobj traits,of
R5930 T19079 T19049 punct .,found
R5931 T19572 T19566 advcl using,predicting
R5932 T19573 T19572 dobj programs,using
R5933 T19574 T19575 amod such,as
R5934 T19081 T19082 advmod Thirdly,identified
R5935 T19575 T19573 prep as,programs
R5936 T19576 T19575 pobj SIFT,as
R5937 T19577 T19576 cc and,SIFT
R5938 T19083 T19082 punct ", ",identified
R5939 T19578 T19576 conj PolyPhen,SIFT
R594 T3055 T3051 punct ", ",array
R5940 T19579 T19580 advmod very,accurate
R5941 T19580 T19565 acomp accurate,is
R5942 T19581 T19582 punct [,49
R5943 T19084 T19085 compound MMU11,QTL
R5944 T19582 T19561 parataxis 49,shown
R5945 T19583 T19582 punct ],49
R5946 T19085 T19082 nsubjpass QTL,identified
R5947 T19584 T19561 punct .,shown
R5948 T19586 T19587 nsubj Four,are
R5949 T19086 T19085 compound growth,QTL
R595 T3114 T3115 det The,role
R5950 T19588 T19586 prep of,Four
R5951 T19589 T19590 det the,genes
R5952 T19087 T19085 acl overlapping,QTL
R5953 T19590 T19588 pobj genes,of
R5954 T19591 T19590 nummod nine,genes
R5955 T19088 T19087 dobj HG11,overlapping
R5956 T19592 T19586 punct (,Four
R5957 T19593 T19586 appos Ubr1,Four
R5958 T19594 T19593 punct ", ",Ubr1
R5959 T19089 T19082 aux have,identified
R596 T3056 T3051 prep including,array
R5960 T19595 T19593 conj Ptpns1,Ubr1
R5961 T19596 T19595 punct ", ",Ptpns1
R5962 T19090 T19082 auxpass been,identified
R5963 T19597 T19595 conj Ubce7ip5,Ptpns1
R5964 T19598 T19597 cc and,Ubce7ip5
R5965 T19091 T19082 prep in,identified
R5966 T19599 T19597 conj Mmp9,Ubce7ip5
R5967 T19600 T19593 punct ;,Ubr1
R5968 T19092 T19093 det a,number
R5969 T19601 T19602 dep all,are
R597 T3057 T3056 pobj growth,including
R5970 T19602 T19593 relcl are,Ubr1
R5971 T19603 T19601 prep of,all
R5972 T19093 T19091 pobj number,in
R5973 T19604 T19603 pobj which,of
R5974 T19605 T19602 prep on,are
R5975 T19606 T19605 pobj MMU2,on
R5976 T19094 T19093 prep of,number
R5977 T19607 T19587 punct ),are
R5978 T19608 T19587 prep of,are
R5979 T19609 T19610 amod particular,interest
R598 T3058 T3057 cc and,growth
R5980 T19095 T19094 pobj crosses,of
R5981 T19610 T19608 pobj interest,of
R5982 T19611 T19587 punct .,are
R5983 T19096 T19082 advcl using,identified
R5984 T19613 T19614 nsubjpass It,suggested
R5985 T19097 T19098 amod different,strains
R5986 T19615 T19614 aux has,suggested
R5987 T19616 T19614 auxpass been,suggested
R5988 T19098 T19096 dobj strains,using
R5989 T19617 T19618 det the,Socs2
R599 T3059 T3057 conj obesity,growth
R5990 T19618 T19619 nsubj Socs2,rely
R5991 T19619 T19614 advcl rely,suggested
R5992 T19099 T19098 compound mouse,strains
R5993 T19620 T19619 aux may,rely
R5994 T19621 T19619 prep on,rely
R5995 T19100 T19101 punct [,37
R5996 T19622 T19623 npadvmod ubiquitination,dependent
R5997 T19623 T19624 amod dependent,degradation
R5998 T19624 T19621 pobj degradation,on
R5999 T19625 T19624 amod proteasomal,degradation
R600 T3115 T3116 nsubjpass role,confirmed
R6000 T19101 T19082 parataxis 37,identified
R6001 T19102 T19103 punct -,41
R6002 T19626 T19627 aux to,inhibit
R6003 T19627 T19619 advcl inhibit,rely
R6004 T19628 T19629 compound Gh,signaling
R6005 T19629 T19627 dobj signaling,inhibit
R6006 T19630 T19631 punct [,23
R6007 T19103 T19101 prep 41,37
R6008 T19631 T19614 parataxis 23,suggested
R6009 T19632 T19631 punct ],23
R601 T3060 T3061 punct [,7
R6010 T19633 T19614 punct .,suggested
R6011 T19104 T19101 punct ],37
R6012 T19635 T19636 nsubjpass Ubr1,involved
R6013 T19105 T19082 punct .,identified
R6014 T19637 T19635 cc and,Ubr1
R6015 T19638 T19635 conj Ubce7ip5,Ubr1
R6016 T19107 T19108 advcl Given,is
R6017 T19639 T19636 auxpass are,involved
R6018 T19640 T19636 advmod both,involved
R6019 T19641 T19636 prep in,involved
R602 T3061 T3041 parataxis 7,used
R6020 T19642 T19643 compound protein,ubiquitination
R6021 T19109 T19110 det the,nature
R6022 T19643 T19641 pobj ubiquitination,in
R6023 T19644 T19636 cc and,involved
R6024 T19645 T19646 compound Ubr1,knockout
R6025 T19646 T19647 compound knockout,mice
R6026 T19110 T19107 dobj nature,Given
R6027 T19647 T19648 nsubj mice,show
R6028 T19648 T19636 conj show,involved
R6029 T19111 T19112 advmod well,documented
R603 T3062 T3063 punct -,13
R6030 T19649 T19650 det an,decrease
R6031 T19650 T19648 dobj decrease,show
R6032 T19651 T19652 nummod 20,%
R6033 T19112 T19110 amod documented,nature
R6034 T19652 T19650 compound %,decrease
R6035 T19653 T19650 prep in,decrease
R6036 T19654 T19655 compound body,weight
R6037 T19113 T19114 advmod sexually,dimorphic
R6038 T19655 T19653 pobj weight,in
R6039 T19656 T19657 advmod partly,due
R604 T3117 T3115 prep of,role
R6040 T19114 T19110 amod dimorphic,nature
R6041 T19657 T19648 prep due,show
R6042 T19658 T19657 pcomp to,due
R6043 T19659 T19660 det a,reduction
R6044 T19115 T19110 prep of,nature
R6045 T19660 T19657 pobj reduction,due
R6046 T19661 T19660 prep in,reduction
R6047 T19116 T19117 compound Gh,secretion
R6048 T19662 T19663 compound adipose,tissue
R6049 T19663 T19661 pobj tissue,in
R605 T3063 T3061 prep 13,7
R6050 T19664 T19665 punct [,51
R6051 T19665 T19648 parataxis 51,show
R6052 T19666 T19665 nummod 50,51
R6053 T19667 T19665 punct ",",51
R6054 T19117 T19115 pobj secretion,of
R6055 T19668 T19665 punct ],51
R6056 T19669 T19648 punct .,show
R6057 T19118 T19117 cc and,secretion
R6058 T19671 T19672 compound Ptpns1,mice
R6059 T19672 T19674 nsubj mice,displayed
R606 T3064 T3061 punct ],7
R6060 T19119 T19120 npadvmod Gh,induced
R6061 T19673 T19672 compound knockout,mice
R6062 T19120 T19121 amod induced,expression
R6063 T19675 T19676 det a,reduction
R6064 T19676 T19674 dobj reduction,displayed
R6065 T19677 T19678 nummod 10,%
R6066 T19121 T19117 conj expression,secretion
R6067 T19678 T19676 compound %,reduction
R6068 T19679 T19676 prep in,reduction
R6069 T19680 T19681 compound body,weight
R607 T3065 T3041 punct .,used
R6070 T19122 T19121 compound gene,expression
R6071 T19681 T19679 pobj weight,in
R6072 T19682 T19683 punct [,52
R6073 T19123 T19124 punct [,43
R6074 T19683 T19674 parataxis 52,displayed
R6075 T19684 T19683 punct ],52
R6076 T19685 T19674 cc and,displayed
R6077 T19124 T19107 parataxis 43,Given
R6078 T19686 T19687 compound Mmp9,mice
R6079 T19687 T19689 nsubj mice,show
R608 T3067 T3068 det The,mouse
R6080 T19125 T19124 nummod 42,43
R6081 T19688 T19687 compound knockout,mice
R6082 T19689 T19674 conj show,displayed
R6083 T19126 T19124 punct ",",43
R6084 T19127 T19124 punct ],43
R6085 T19690 T19691 det a,reduction
R6086 T19691 T19689 dobj reduction,show
R6087 T19128 T19108 punct ", ",is
R6088 T19692 T19691 prep in,reduction
R6089 T19693 T19692 pobj size,in
R609 T3118 T3117 pobj Socs2,of
R6090 T19694 T19691 cc and,reduction
R6091 T19129 T19108 nsubj it,is
R6092 T19695 T19696 advmod drastically,reduced
R6093 T19696 T19697 amod reduced,length
R6094 T19130 T19108 acomp probable,is
R6095 T19697 T19691 conj length,reduction
R6096 T19698 T19697 compound bone,length
R6097 T19699 T19700 punct [,53
R6098 T19131 T19132 mark that,reside
R6099 T19700 T19689 parataxis 53,show
R610 T3068 T3079 nsubj mouse,is
R6100 T19701 T19700 punct ],53
R6101 T19702 T19689 punct .,show
R6102 T19132 T19108 ccomp reside,is
R6103 T19704 T19705 nsubj All,are
R6104 T19706 T19704 prep of,All
R6105 T19133 T19134 det the,mutation
R6106 T19707 T19708 det these,genes
R6107 T19708 T19706 pobj genes,of
R6108 T19134 T19132 nsubj mutation,reside
R6109 T19709 T19710 amod excellent,genes
R611 T3069 T3070 nmod C57Bl,hg
R6110 T19135 T19134 amod underlying,mutation
R6111 T19136 T19134 prep in,mutation
R6112 T19710 T19705 attr genes,are
R6113 T19137 T19138 det the,HG11
R6114 T19711 T19710 amod functional,genes
R6115 T19712 T19711 cc and,functional
R6116 T19138 T19136 pobj HG11,in
R6117 T19713 T19711 conj positional,functional
R6118 T19714 T19715 compound hg,modifier
R6119 T19139 T19138 amod congenic,HG11
R612 T3070 T3068 nmod hg,mouse
R6120 T19715 T19710 compound modifier,genes
R6121 T19716 T19710 compound candidate,genes
R6122 T19717 T19705 cc and,are
R6123 T19140 T19132 aux may,reside
R6124 T19718 T19719 det this,information
R6125 T19719 T19720 nsubjpass information,incorporated
R6126 T19141 T19132 prep in,reside
R6127 T19720 T19705 conj incorporated,are
R6128 T19721 T19720 aux can,incorporated
R6129 T19722 T19720 auxpass be,incorporated
R613 T3119 T3115 prep in,role
R6130 T19723 T19720 prep into,incorporated
R6131 T19724 T19725 amod future,studies
R6132 T19142 T19143 det a,gene
R6133 T19725 T19723 pobj studies,into
R6134 T19726 T19727 amod fine,mapping
R6135 T19727 T19725 compound mapping,studies
R6136 T19728 T19720 punct .,incorporated
R6137 T19143 T19141 pobj gene,in
R6138 T19144 T19143 acl enhancing,gene
R6139 T19145 T19146 npadvmod Gh,induced
R614 T3071 T3070 punct /,hg
R6140 T19146 T19147 amod induced,effects
R6141 T19147 T19144 dobj effects,enhancing
R6142 T19148 T19149 npadvmod sex,specific
R6143 T19149 T19147 amod specific,effects
R6144 T19150 T19149 punct -,specific
R6145 T19151 T19108 punct .,is
R6146 T19153 T19154 det The,gene
R6147 T19154 T19157 nsubj gene,are
R6148 T19155 T19154 amod structural,gene
R6149 T19156 T19154 compound Gh,gene
R615 T3072 T3070 nmod 6J,hg
R6150 T19158 T19154 appos itself,gene
R6151 T19159 T19154 cc and,gene
R6152 T19160 T19154 conj Stat5b,gene
R6153 T19161 T19162 amod excellent,candidates
R6154 T19162 T19157 attr candidates,are
R6155 T19163 T19157 punct .,are
R6156 T19165 T19166 det The,role
R6157 T19166 T19168 nsubj role,include
R6158 T19167 T19166 amod potential,role
R6159 T19169 T19166 prep of,role
R616 T3073 T3070 punct -,hg
R6160 T19170 T19169 pobj Gh,of
R6161 T19171 T19168 aux would,include
R6162 T19172 T19168 dobj polymorphism,include
R6163 T19173 T19174 dep that,alters
R6164 T19174 T19172 advcl alters,polymorphism
R6165 T19175 T19176 compound protein,function
R6166 T19176 T19174 dobj function,alters
R6167 T19177 T19174 prep in,alters
R6168 T19178 T19179 det the,absence
R6169 T19179 T19177 pobj absence,in
R617 T3074 T3070 nmod hg,hg
R6170 T19180 T19179 prep of,absence
R6171 T19181 T19180 pobj Socs2,of
R6172 T19182 T19174 cc or,alters
R6173 T19183 T19184 dep that,causes
R6174 T19184 T19174 conj causes,alters
R6175 T19185 T19186 amod transcriptional,deregulation
R6176 T19186 T19184 dobj deregulation,causes
R6177 T19187 T19186 prep of,deregulation
R6178 T19188 T19187 pobj Gh,of
R6179 T19189 T19168 punct .,include
R618 T3120 T3121 det the,phenotype
R6180 T19191 T19192 advmod Additionally,explain
R6181 T19193 T19192 punct ", ",explain
R6182 T19194 T19195 amod functional,variation
R6183 T19195 T19192 nsubj variation,explain
R6184 T19196 T19195 prep in,variation
R6185 T19197 T19196 pobj Stat5b,in
R6186 T19198 T19192 aux may,explain
R6187 T19199 T19200 det the,phenotypes
R6188 T19200 T19192 dobj phenotypes,explain
R6189 T19896 T19897 det The,strains
R619 T3075 T3070 punct /,hg
R6190 T19897 T19900 nsubj strains,confirm
R6191 T19898 T19899 npadvmod speed,congenic
R6192 T19899 T19897 amod congenic,strains
R6193 T19901 T19897 acl developed,strains
R6194 T19902 T19901 advmod herein,developed
R6195 T19903 T19904 advmod previously,identified
R6196 T19904 T19905 amod identified,QTL
R6197 T19905 T19900 dobj QTL,confirm
R6198 T19906 T19907 npadvmod genome,wide
R6199 T19907 T19905 amod wide,QTL
R620 T3076 T3077 punct (,HG
R6200 T19908 T19907 punct -,wide
R6201 T19909 T19905 acl affecting,QTL
R6202 T19910 T19909 dobj growth,affecting
R6203 T19911 T19910 punct ", ",growth
R6204 T19912 T19910 conj obesity,growth
R6205 T19913 T19912 cc and,obesity
R6206 T19914 T19915 compound carcass,composition
R6207 T19915 T19912 conj composition,obesity
R6208 T19916 T19900 punct .,confirm
R6209 T19918 T19919 poss Our,approach
R621 T3077 T3070 parataxis HG,hg
R6210 T19919 T19923 nsubj approach,provided
R6211 T19920 T19919 amod novel,approach
R6212 T19921 T19922 amod congenic,development
R6213 T19922 T19919 compound development,approach
R6214 T19924 T19919 prep on,approach
R6215 T19925 T19924 pobj MMU2,on
R6216 T19926 T19923 dobj confirmation,provided
R6217 T19927 T19926 prep of,confirmation
R6218 T19928 T19929 compound QTL,hg
R6219 T19929 T19931 compound hg,interactions
R622 T3121 T3119 pobj phenotype,in
R6220 T19930 T19929 punct -,hg
R6221 T19931 T19927 pobj interactions,of
R6222 T19932 T19926 punct ", ",confirmation
R6223 T19933 T19934 dep which,aid
R6224 T19934 T19926 relcl aid,confirmation
R6225 T19935 T19934 aux will,aid
R6226 T19936 T19934 advmod significantly,aid
R6227 T19937 T19934 prep in,aid
R6228 T19938 T19939 amod future,experiments
R6229 T19939 T19937 pobj experiments,in
R623 T3078 T3077 punct ),HG
R6230 T19940 T19941 amod fine,mapping
R6231 T19941 T19939 compound mapping,experiments
R6232 T19942 T19923 punct .,provided
R6233 T19944 T19945 det The,identification
R6234 T19945 T19946 nsubj identification,provide
R6235 T19947 T19945 prep of,identification
R6236 T19948 T19949 det the,mediators
R6237 T19949 T19947 pobj mediators,of
R6238 T19950 T19949 amod molecular,mediators
R6239 T19951 T19949 prep of,mediators
R624 T3080 T3081 det a,model
R6240 T19952 T19953 compound QTL,hg
R6241 T19953 T19955 compound hg,epistasis
R6242 T19954 T19953 punct -,hg
R6243 T19955 T19951 pobj epistasis,of
R6244 T19956 T19957 advmod as,as
R6245 T19957 T19949 cc as,mediators
R6246 T19958 T19957 advmod well,as
R6247 T19959 T19960 det the,QTG
R6248 T19960 T19949 conj QTG,mediators
R6249 T19961 T19960 prep for,QTG
R625 T3122 T3121 compound HG,phenotype
R6250 T19962 T19963 det the,congenics
R6251 T19963 T19961 pobj congenics,for
R6252 T19964 T19963 amod remaining,congenics
R6253 T19965 T19946 aux will,provide
R6254 T19966 T19967 amod essential,information
R6255 T19967 T19946 dobj information,provide
R6256 T19968 T19967 prep on,information
R6257 T19969 T19970 det the,architecture
R6258 T19970 T19968 pobj architecture,on
R6259 T19971 T19970 amod molecular,architecture
R626 T3081 T3079 attr model,is
R6260 T19972 T19970 amod genetic,architecture
R6261 T19973 T19970 prep of,architecture
R6262 T19974 T19973 pobj growth,of
R6263 T19975 T19974 cc and,growth
R6264 T19976 T19974 conj obesity,growth
R6265 T19977 T19946 punct .,provide
R6266 T20228 T20229 compound Mouse,strains
R6267 T20230 T20229 cc and,strains
R6268 T20231 T20229 conj husbandry,strains
R6269 T20233 T20234 nmod CAST,EiJ
R627 T3082 T3081 prep of,model
R6270 T20234 T20236 nmod EiJ,mice
R6271 T20235 T20234 punct /,EiJ
R6272 T20236 T20242 nsubjpass mice,purchased
R6273 T20237 T20238 punct (,#
R6274 T20238 T20236 parataxis #,mice
R6275 T20239 T20238 compound stock,#
R6276 T20240 T20238 nummod 000928,#
R6277 T20241 T20238 punct ),#
R6278 T20243 T20242 auxpass were,purchased
R6279 T20244 T20242 prep from,purchased
R628 T3083 T3084 amod systemic,overgrowth
R6280 T20245 T20246 det the,Laboratory
R6281 T20246 T20244 pobj Laboratory,from
R6282 T20247 T20246 compound Jackson,Laboratory
R6283 T20248 T20242 punct .,purchased
R6284 T20250 T20251 det The,mutation
R6285 T20251 T20253 nsubjpass mutation,identified
R6286 T20252 T20251 compound hg,mutation
R6287 T20254 T20253 auxpass was,identified
R6288 T20255 T20253 advmod originally,identified
R6289 T20256 T20253 prep in,identified
R629 T3123 T3116 auxpass was,confirmed
R6290 T20257 T20258 det a,line
R6291 T20258 T20256 pobj line,in
R6292 T20259 T20258 amod selected,line
R6293 T20260 T20258 compound outcross,line
R6294 T20261 T20262 punct [,22
R6295 T20262 T20253 parataxis 22,identified
R6296 T20263 T20262 punct ],22
R6297 T20264 T20253 cc and,identified
R6298 T20265 T20266 aux has,introgressed
R6299 T20266 T20253 conj introgressed,identified
R630 T3084 T3082 pobj overgrowth,of
R6300 T20267 T20266 auxpass been,introgressed
R6301 T20268 T20266 prep onto,introgressed
R6302 T20269 T20270 det a,background
R6303 T20270 T20268 pobj background,onto
R6304 T20271 T20270 compound B6,background
R6305 T20272 T20266 prep via,introgressed
R6306 T20273 T20274 nummod nine,backcrosses
R6307 T20274 T20272 pobj backcrosses,via
R6308 T20275 T20276 aux to,create
R6309 T20276 T20266 advcl create,introgressed
R631 T3085 T3081 acl resulting,model
R6310 T20277 T20278 det the,strain
R6311 T20278 T20276 dobj strain,create
R6312 T20279 T20278 compound HG,strain
R6313 T20280 T20253 punct .,identified
R6314 T20282 T20283 compound HG,mice
R6315 T20283 T20284 nsubj mice,were
R6316 T20285 T20283 acl used,mice
R6317 T20286 T20285 prep in,used
R6318 T20287 T20288 det this,experiment
R6319 T20288 T20286 pobj experiment,in
R632 T3124 T3116 agent by,confirmed
R6320 T20289 T20284 prep from,were
R6321 T20290 T20291 det the,generation
R6322 T20291 T20289 pobj generation,from
R6323 T20292 T20291 amod 17th,generation
R6324 T20293 T20292 cc or,17th
R6325 T20294 T20292 conj later,17th
R6326 T20295 T20291 prep of,generation
R6327 T20296 T20295 pobj inbreeding,of
R6328 T20297 T20284 punct .,were
R6329 T20299 T20300 nsubjpass Mice,housed
R633 T3086 T3085 prep from,resulting
R6330 T20301 T20300 auxpass were,housed
R6331 T20302 T20300 prep in,housed
R6332 T20303 T20304 compound polycarbonate,cages
R6333 T20304 T20302 pobj cages,in
R6334 T20305 T20300 prep under,housed
R6335 T20306 T20307 amod controlled,conditions
R6336 T20307 T20305 pobj conditions,under
R6337 T20308 T20307 prep of,conditions
R6338 T20309 T20308 pobj temperature,of
R6339 T20310 T20311 punct (,°C
R634 T3087 T3088 det a,deletion
R6340 T20311 T20309 parataxis °C,temperature
R6341 T20312 T20311 nummod 21,°C
R6342 T20313 T20311 punct ±,°C
R6343 T20314 T20315 nummod 2,°C
R6344 T20315 T20311 appos °C,°C
R6345 T20316 T20311 punct ),°C
R6346 T20317 T20309 punct ", ",temperature
R6347 T20318 T20309 conj humidity,temperature
R6348 T20319 T20320 punct (,%
R6349 T20320 T20318 parataxis %,humidity
R635 T3088 T3086 pobj deletion,from
R6350 T20321 T20322 quantmod 40,70
R6351 T20322 T20320 nummod 70,%
R6352 T20323 T20322 punct –,70
R6353 T20324 T20320 punct ),%
R6354 T20325 T20318 cc and,humidity
R6355 T20326 T20318 conj lighting,humidity
R6356 T20327 T20328 punct (,dark
R6357 T20328 T20326 parataxis dark,lighting
R6358 T20329 T20330 nummod 14,h
R6359 T20330 T20331 compound h,light
R636 T3125 T3126 det an,mouse
R6360 T20331 T20328 dep light,dark
R6361 T20332 T20328 punct ", ",dark
R6362 T20333 T20334 nummod 10,h
R6363 T20334 T20328 compound h,dark
R6364 T20335 T20328 punct ", ",dark
R6365 T20336 T20337 nsubj lights,on
R6366 T20337 T20328 advmod on,dark
R6367 T20338 T20337 prep at,on
R6368 T20339 T20340 nummod 7,AM
R6369 T20340 T20338 pobj AM,at
R637 T3089 T3088 amod spontaneous,deletion
R6370 T20341 T20328 punct ),dark
R6371 T20342 T20300 punct ", ",housed
R6372 T20343 T20300 cc and,housed
R6373 T20344 T20300 conj managed,housed
R6374 T20345 T20344 prep according,managed
R6375 T20346 T20345 prep to,according
R6376 T20347 T20348 det the,guidelines
R6377 T20348 T20346 pobj guidelines,to
R6378 T20349 T20348 prep of,guidelines
R6379 T20350 T20351 det the,Association
R638 T3090 T3088 prep on,deletion
R6380 T20351 T20349 pobj Association,of
R6381 T20352 T20351 compound American,Association
R6382 T20353 T20351 prep for,Association
R6383 T20354 T20353 pobj Accreditation,for
R6384 T20355 T20354 prep of,Accreditation
R6385 T20356 T20357 compound Laboratory,Animal
R6386 T20357 T20358 compound Animal,Care
R6387 T20358 T20355 pobj Care,of
R6388 T20359 T20351 punct (,Association
R6389 T20360 T20351 appos AAALAC,Association
R639 T3091 T3090 pobj MMU10,on
R6390 T20361 T20300 punct ),housed
R6391 T20362 T20300 punct .,housed
R6392 T20781 T20782 nsubjpass DNA,isolated
R6393 T20783 T20781 prep for,DNA
R6394 T20784 T20783 pobj genotyping,for
R6395 T20785 T20782 auxpass was,isolated
R6396 T20786 T20782 prep from,isolated
R6397 T20787 T20788 quantmod 1.0,2.0
R6398 T20788 T20790 nummod 2.0,mm
R6399 T20789 T20788 punct –,2.0
R640 T3126 T3124 pobj mouse,by
R6400 T20790 T20791 compound mm,clips
R6401 T20791 T20786 pobj clips,from
R6402 T20792 T20791 compound tail,clips
R6403 T20793 T20782 prep by,isolated
R6404 T20794 T20793 pcomp digesting,by
R6405 T20795 T20794 prep with,digesting
R6406 T20796 T20797 compound Proteinase,K
R6407 T20797 T20795 pobj K,with
R6408 T20798 T20799 punct (,Fisher
R6409 T20799 T20797 parataxis Fisher,K
R641 T3092 T3091 punct ", ",MMU10
R6410 T20800 T20799 punct ),Fisher
R6411 T20801 T20794 prep at,digesting
R6412 T20802 T20803 nummod 55,°C
R6413 T20803 T20801 pobj °C,at
R6414 T20804 T20794 prep in,digesting
R6415 T20805 T20806 det a,buffer
R6416 T20806 T20804 pobj buffer,in
R6417 T20807 T20806 acl composed,buffer
R6418 T20808 T20807 prep of,composed
R6419 T20809 T20810 nummod 0.45,%
R642 T3093 T3094 dep which,eliminates
R6420 T20810 T20811 compound %,NP40
R6421 T20811 T20808 pobj NP40,of
R6422 T20812 T20813 punct (,Sigma
R6423 T20813 T20811 parataxis Sigma,NP40
R6424 T20814 T20813 punct ),Sigma
R6425 T20815 T20811 punct ", ",NP40
R6426 T20816 T20817 nummod 0.45,%
R6427 T20817 T20818 compound %,Tween
R6428 T20818 T20811 conj Tween,NP40
R6429 T20819 T20818 nummod 20,Tween
R643 T3094 T3091 relcl eliminates,MMU10
R6430 T20820 T20821 punct (,Fisher
R6431 T20821 T20818 parataxis Fisher,Tween
R6432 T20822 T20821 punct ),Fisher
R6433 T20823 T20818 cc and,Tween
R6434 T20824 T20825 compound 1X,buffer
R6435 T20825 T20818 conj buffer,Tween
R6436 T20826 T20825 compound PCR,buffer
R6437 T20827 T20828 punct (,Promega
R6438 T20828 T20825 parataxis Promega,buffer
R6439 T20829 T20828 punct ),Promega
R644 T3095 T3094 dobj expression,eliminates
R6440 T20830 T20782 punct .,isolated
R6441 T20832 T20833 det The,product
R6442 T20833 T20834 nsubjpass product,diluted
R6443 T20835 T20833 prep of,product
R6444 T20836 T20837 det this,digestion
R6445 T20837 T20835 pobj digestion,of
R6446 T20838 T20834 auxpass was,diluted
R6447 T20839 T20840 punct (,1
R6448 T20840 T20834 parataxis 1,diluted
R6449 T20841 T20842 punct :,10
R645 T3096 T3095 prep of,expression
R6450 T20842 T20840 prep 10,1
R6451 T20843 T20840 punct ),1
R6452 T20844 T20834 prep in,diluted
R6453 T20845 T20846 amod sterile,H2O
R6454 T20846 T20844 pobj H2O,in
R6455 T20847 T20834 cc and,diluted
R6456 T20848 T20834 conj used,diluted
R6457 T20849 T20848 prep for,used
R6458 T20850 T20849 pobj genotyping,for
R6459 T20851 T20848 prep without,used
R646 T3097 T3098 det the,gene
R6460 T20852 T20853 amod further,purification
R6461 T20853 T20851 pobj purification,without
R6462 T20854 T20834 punct .,diluted
R6463 T20856 T20857 compound Microsatellite,genotyping
R6464 T20857 T20858 nsubjpass genotyping,performed
R6465 T20859 T20858 auxpass was,performed
R6466 T20860 T20858 advcl using,performed
R6467 T20861 T20862 amod standard,protocols
R6468 T20862 T20860 dobj protocols,using
R6469 T20863 T20862 nmod PCR,protocols
R647 T3127 T3128 advmod independently,engineered
R6470 T20864 T20863 cc and,PCR
R6471 T20865 T20866 compound gel,electrophoresis
R6472 T20866 T20863 conj electrophoresis,PCR
R6473 T20867 T20858 punct .,performed
R6474 T20869 T20870 compound Reaction,conditions
R6475 T20870 T20871 nsubjpass conditions,listed
R6476 T20872 T20870 prep for,conditions
R6477 T20873 T20874 det each,marker
R6478 T20874 T20872 pobj marker,for
R6479 T20875 T20871 auxpass are,listed
R648 T3098 T3096 pobj gene,of
R6480 T20876 T20871 prep in,listed
R6481 T20877 T20878 amod Additional,1
R6482 T20878 T20876 pobj 1,in
R6483 T20879 T20878 nmod File,1
R6484 T20880 T20878 cc and,1
R6485 T20881 T20878 conj 2,1
R6486 T20882 T20871 punct .,listed
R6487 T20884 T20885 npadvmod MMU2,congenic
R6488 T20885 T20886 amod congenic,mice
R6489 T20886 T20887 nsubjpass mice,genotyped
R649 T3099 T3098 nmod Socs2,gene
R6490 T20888 T20887 auxpass were,genotyped
R6491 T20889 T20887 prep for,genotyped
R6492 T20890 T20889 pobj hg,for
R6493 T20891 T20887 advcl using,genotyped
R6494 T20892 T20893 det a,assay
R6495 T20893 T20891 dobj assay,using
R6496 T20894 T20895 nummod two,primer
R6497 T20895 T20893 compound primer,assay
R6498 T20896 T20893 compound genotyping,assay
R6499 T20897 T20887 punct .,genotyped
R650 T3100 T3099 punct (,Socs2
R6500 T20899 T20900 nummod One,set
R6501 T20900 T20902 nsubj set,spanned
R6502 T20901 T20900 compound primer,set
R6503 T20903 T20900 punct (,set
R6504 T20904 T20905 compound HG,F
R6505 T20905 T20900 appos F,set
R6506 T20906 T20905 punct -,F
R6507 T20907 T20905 punct ", ",F
R6508 T20908 T20905 appos ctcctgtctgggctgtgag,F
R6509 T20909 T20905 cc and,F
R651 T3101 T3099 appos suppressor,Socs2
R6510 T20910 T20911 compound HG,R
R6511 T20911 T20905 conj R,F
R6512 T20912 T20911 punct -,R
R6513 T20913 T20911 punct ", ",R
R6514 T20914 T20911 appos caaaggcagaagtggggtaa,R
R6515 T20915 T20902 punct ),spanned
R6516 T20916 T20917 det the,deletion
R6517 T20917 T20902 dobj deletion,spanned
R6518 T20918 T20917 compound hg,deletion
R6519 T20919 T20902 advcl producing,spanned
R652 T3128 T3126 amod engineered,mouse
R6520 T20920 T20921 det a,product
R6521 T20921 T20919 dobj product,producing
R6522 T20922 T20923 nummod 447,bp
R6523 T20923 T20921 compound bp,product
R6524 T20924 T20919 prep in,producing
R6525 T20925 T20926 nmod hg,hg
R6526 T20926 T20928 nmod hg,mice
R6527 T20927 T20926 punct /,hg
R6528 T20928 T20924 pobj mice,in
R6529 T20929 T20926 cc and,hg
R653 T3102 T3101 prep of,suppressor
R6530 T20930 T20931 punct +,hg
R6531 T20931 T20926 conj hg,hg
R6532 T20932 T20931 punct /,hg
R6533 T20933 T20902 punct .,spanned
R6534 T20935 T20936 det The,set
R6535 T20936 T20938 nsubj set,amplified
R6536 T20937 T20936 amod other,set
R6537 T20939 T20936 punct (,set
R6538 T20940 T20936 appos CRADD3a.F,set
R6539 T20941 T20940 punct ", ",CRADD3a.F
R654 T3103 T3104 compound cytokine,signaling
R6540 T20942 T20940 appos gtccatcagcattcctgaaa,CRADD3a.F
R6541 T20943 T20940 cc and,CRADD3a.F
R6542 T20944 T20940 conj CRADD3.R,CRADD3a.F
R6543 T20945 T20944 punct ", ",CRADD3.R
R6544 T20946 T20944 appos tgtccagcaacagcattgtc,CRADD3.R
R6545 T20947 T20938 punct ),amplified
R6546 T20948 T20949 det a,amplicon
R6547 T20949 T20938 dobj amplicon,amplified
R6548 T20950 T20951 nummod 232,bp
R6549 T20951 T20949 compound bp,amplicon
R655 T3104 T3102 pobj signaling,of
R6550 T20952 T20949 compound Cradd,amplicon
R6551 T20953 T20949 punct (,amplicon
R6552 T20954 T20949 acl located,amplicon
R6553 T20955 T20954 prep within,located
R6554 T20956 T20957 det the,deletion
R6555 T20957 T20955 pobj deletion,within
R6556 T20958 T20957 compound hg,deletion
R6557 T20959 T20938 punct ),amplified
R6558 T20960 T20938 prep in,amplified
R6559 T20961 T20962 punct +,+
R656 T3129 T3130 nmod Socs2,knockout
R6560 T20962 T20964 punct +,mice
R6561 T20963 T20962 punct /,+
R6562 T20964 T20960 pobj mice,in
R6563 T20965 T20962 cc and,+
R6564 T20966 T20967 punct +,hg
R6565 T20967 T20962 conj hg,+
R6566 T20968 T20967 punct /,hg
R6567 T20969 T20970 punct [,54
R6568 T20970 T20938 parataxis 54,amplified
R6569 T20971 T20970 punct ],54
R657 T3105 T3104 nummod 2,signaling
R6570 T20972 T20938 punct .,amplified
R6571 T20974 T20975 det The,temperature
R6572 T20975 T20978 nsubj temperature,was
R6573 T20976 T20977 npadvmod PCR,annealing
R6574 T20977 T20975 amod annealing,temperature
R6575 T20979 T20980 nummod 55,°C
R6576 T20980 T20978 attr °C,was
R6577 T20981 T20978 cc and,was
R6578 T20982 T20983 det the,concentration
R6579 T20983 T20985 nsubj concentration,was
R658 T3106 T3098 punct ),gene
R6580 T20984 T20983 compound MgCl2,concentration
R6581 T20985 T20978 conj was,was
R6582 T20986 T20987 nummod 1.5,mM
R6583 T20987 T20985 attr mM,was
R6584 T20988 T20985 punct .,was
R6585 T21608 T21607 prep of,Development
R6586 T21609 T21610 nmod B6.CAST,MMU2
R6587 T21610 T21613 nmod MMU2,strains
R6588 T21611 T21609 cc and,B6.CAST
R6589 T21612 T21609 conj HG.CAST,B6.CAST
R659 T3107 T3108 punct [,14
R6590 T21613 T21608 pobj strains,of
R6591 T21614 T21615 npadvmod speed,congenic
R6592 T21615 T21613 amod congenic,strains
R6593 T21617 T21618 det All,strains
R6594 T21618 T21621 nsubjpass strains,developed
R6595 T21619 T21620 npadvmod speed,congenic
R6596 T21620 T21618 amod congenic,strains
R6597 T21622 T21621 auxpass were,developed
R6598 T21623 T21621 advcl starting,developed
R6599 T21624 T21623 prep with,starting
R660 T3130 T3126 compound knockout,mouse
R6600 T21625 T21626 det an,cross
R6601 T21626 T21624 pobj cross,with
R6602 T21627 T21626 amod initial,cross
R6603 T21628 T21626 prep between,cross
R6604 T21629 T21630 det a,male
R6605 T21630 T21628 pobj male,between
R6606 T21631 T21630 compound CAST,male
R6607 T21632 T21630 cc and,male
R6608 T21633 T21634 compound HG,females
R6609 T21634 T21630 conj females,male
R661 T3131 T3129 punct -,Socs2
R6610 T21635 T21636 punct (,Figure
R6611 T21636 T21623 parataxis Figure,starting
R6612 T21637 T21636 nummod 1,Figure
R6613 T21638 T21636 punct ),Figure
R6614 T21639 T21640 punct [,6
R6615 T21640 T21621 parataxis 6,developed
R6616 T21641 T21640 nummod 5,6
R6617 T21642 T21640 punct ",",6
R6618 T21643 T21640 punct ],6
R6619 T21644 T21621 punct .,developed
R662 T3108 T3079 parataxis 14,is
R6620 T21646 T21647 amod Male,mice
R6621 T21647 T21649 nsubjpass mice,backcrossed
R6622 T21648 T21647 compound F1,mice
R6623 T21650 T21649 auxpass were,backcrossed
R6624 T21651 T21649 advmod then,backcrossed
R6625 T21652 T21649 prep to,backcrossed
R6626 T21653 T21654 compound HG,females
R6627 T21654 T21652 pobj females,to
R6628 T21655 T21649 punct .,backcrossed
R6629 T21657 T21658 det All,males
R663 T3109 T3110 punct -,16
R6630 T21658 T21677 nsubjpass males,genotyped
R6631 T21659 T21658 nmod agouti,males
R6632 T21660 T21661 punct (,located
R6633 T21661 T21658 parataxis located,males
R6634 T21662 T21663 det the,locus
R6635 T21663 T21661 nsubjpass locus,located
R6636 T21664 T21663 amod dominant,locus
R6637 T21665 T21666 amod nonagouti,a
R6638 T21666 T21663 amod a,locus
R6639 T21667 T21666 punct (,a
R664 T3132 T3129 punct /,Socs2
R6640 T21668 T21663 punct ),locus
R6641 T21669 T21661 auxpass is,located
R6642 T21670 T21661 prep at,located
R6643 T21671 T21672 nummod 154.8,Mbp
R6644 T21672 T21670 pobj Mbp,at
R6645 T21673 T21661 prep on,located
R6646 T21674 T21673 pobj MMU2,on
R6647 T21675 T21661 punct ),located
R6648 T21676 T21658 compound N2,males
R6649 T21678 T21677 auxpass were,genotyped
R665 T3133 T3129 punct -,Socs2
R6650 T21679 T21677 prep for,genotyped
R6651 T21680 T21681 nummod 79,markers
R6652 T21681 T21679 pobj markers,for
R6653 T21682 T21681 compound microsatellite,markers
R6654 T21683 T21684 punct (,File
R6655 T21684 T21677 parataxis File,genotyped
R6656 T21685 T21684 amod Additional,File
R6657 T21686 T21684 nummod 1,File
R6658 T21687 T21684 punct ),File
R6659 T21688 T21677 punct .,genotyped
R666 T3110 T3108 prep 16,14
R6660 T21690 T21691 det These,markers
R6661 T21691 T21692 nsubjpass markers,spaced
R6662 T21693 T21692 auxpass were,spaced
R6663 T21694 T21692 advmod evenly,spaced
R6664 T21695 T21692 prep across,spaced
R6665 T21696 T21697 det the,genome
R6666 T21697 T21695 pobj genome,across
R6667 T21698 T21692 punct ", ",spaced
R6668 T21699 T21700 advmod except,in
R6669 T21700 T21692 prep in,spaced
R667 T3134 T3135 dep which,shared
R6670 T21701 T21700 pobj regions,in
R6671 T21702 T21703 advmod previously,identified
R6672 T21703 T21701 acl identified,regions
R6673 T21704 T21703 prep as,identified
R6674 T21705 T21704 pcomp harboring,as
R6675 T21706 T21705 dobj QTL,harboring
R6676 T21707 T21708 punct [,1
R6677 T21708 T21705 parataxis 1,harboring
R6678 T21709 T21708 punct ],1
R6679 T21710 T21701 punct ", ",regions
R668 T3111 T3108 punct ],14
R6680 T21711 T21712 dep which,screened
R6681 T21712 T21701 relcl screened,regions
R6682 T21713 T21712 auxpass were,screened
R6683 T21714 T21715 advmod more,densely
R6684 T21715 T21712 advmod densely,screened
R6685 T21716 T21692 punct .,spaced
R6686 T21718 T21719 det The,male
R6687 T21719 T21725 nsubjpass male,selected
R6688 T21720 T21719 punct """",male
R6689 T21721 T21719 amod best,male
R669 T3112 T3079 punct .,is
R6690 T21722 T21719 punct """",male
R6691 T21723 T21724 compound N2,agouti
R6692 T21724 T21719 compound agouti,male
R6693 T21726 T21719 prep with,male
R6694 T21727 T21728 det the,level
R6695 T21728 T21726 pobj level,with
R6696 T21729 T21728 amod lowest,level
R6697 T21730 T21728 prep of,level
R6698 T21731 T21732 npadvmod genome,wide
R6699 T21732 T21734 amod wide,heterozygosity
R670 T3135 T3126 relcl shared,mouse
R6700 T21733 T21732 punct -,wide
R6701 T21734 T21730 pobj heterozygosity,of
R6702 T21735 T21734 amod unwanted,heterozygosity
R6703 T21736 T21737 mark while,maintaining
R6704 T21737 T21725 advcl maintaining,selected
R6705 T21738 T21739 compound CAST,alleles
R6706 T21739 T21737 dobj alleles,maintaining
R6707 T21740 T21739 prep for,alleles
R6708 T21741 T21742 det all,markers
R6709 T21742 T21740 pobj markers,for
R671 T3136 T3137 det a,number
R6710 T21743 T21742 compound MMU2,markers
R6711 T21744 T21725 auxpass was,selected
R6712 T21745 T21725 prep for,selected
R6713 T21746 T21745 pobj breeding,for
R6714 T21747 T21725 punct .,selected
R6715 T21749 T21750 det This,scheme
R6716 T21750 T21752 nsubjpass scheme,used
R6717 T21751 T21750 compound selection,scheme
R6718 T21753 T21752 auxpass was,used
R6719 T21754 T21752 prep at,used
R672 T3137 T3135 dobj number,shared
R6720 T21755 T21756 det each,generation
R6721 T21756 T21754 pobj generation,at
R6722 T21757 T21758 mark until,identified
R6723 T21758 T21752 advcl identified,used
R6724 T21759 T21760 det a,male
R6725 T21760 T21758 nsubjpass male,identified
R6726 T21761 T21760 compound N4,male
R6727 T21762 T21758 auxpass was,identified
R6728 T21763 T21758 prep as,identified
R6729 T21764 T21765 amod homozygous,HG
R673 T3138 T3137 prep of,number
R6730 T21765 T21763 pobj HG,as
R6731 T21766 T21765 prep for,HG
R6732 T21767 T21768 det all,markers
R6733 T21768 T21766 pobj markers,for
R6734 T21769 T21768 acl typed,markers
R6735 T21770 T21769 prep outside,typed
R6736 T21771 T21770 pobj MMU2,outside
R6737 T21772 T21752 punct .,used
R6738 T21774 T21775 prep After,identified
R6739 T21776 T21777 det an,backcross
R674 T3220 T3219 prep of,basis
R6740 T21777 T21774 pobj backcross,After
R6741 T21778 T21777 amod additional,backcross
R6742 T21779 T21777 prep to,backcross
R6743 T21780 T21781 compound HG,females
R6744 T21781 T21779 pobj females,to
R6745 T21782 T21775 punct ", ",identified
R6746 T21783 T21784 amod recombinant,males
R6747 T21784 T21775 nsubjpass males,identified
R6748 T21785 T21775 auxpass were,identified
R6749 T21786 T21775 advcl providing,identified
R675 T3221 T3222 det these,interactions
R6750 T21787 T21788 det the,foundation
R6751 T21788 T21786 dobj foundation,providing
R6752 T21789 T21788 prep for,foundation
R6753 T21790 T21791 det the,regions
R6754 T21791 T21789 pobj regions,for
R6755 T21792 T21791 nummod four,regions
R6756 T21793 T21791 amod overlapping,regions
R6757 T21794 T21791 compound donor,regions
R6758 T21795 T21775 punct .,identified
R6759 T21797 T21798 amod Selected,males
R676 T3139 T3138 pobj phenotypes,of
R6760 T21798 T21800 nsubjpass males,backcrossed
R6761 T21799 T21798 amod recombinant,males
R6762 T21801 T21800 auxpass were,backcrossed
R6763 T21802 T21800 advmod then,backcrossed
R6764 T21803 T21800 prep to,backcrossed
R6765 T21804 T21805 preconj both,B6
R6766 T21805 T21806 nmod B6,females
R6767 T21806 T21803 pobj females,to
R6768 T21807 T21805 cc and,B6
R6769 T21808 T21805 conj HG,B6
R677 T3222 T3220 pobj interactions,of
R6770 T21809 T21810 aux to,create
R6771 T21810 T21800 advcl create,backcrossed
R6772 T21811 T21810 dobj strains,create
R6773 T21812 T21811 punct ", ",strains
R6774 T21813 T21814 dep which,were
R6775 T21814 T21811 relcl were,strains
R6776 T21815 T21816 npadvmod B6,congenic
R6777 T21816 T21814 acomp congenic,were
R6778 T21817 T21818 punct (,+
R6779 T21818 T21815 punct +,B6
R678 T3223 T3217 punct ", ",forms
R6780 T21819 T21818 punct +,+
R6781 T21820 T21818 punct /,+
R6782 T21821 T21818 punct ),+
R6783 T21822 T21815 cc or,B6
R6784 T21823 T21815 conj HG,B6
R6785 T21824 T21825 punct (,hg
R6786 T21825 T21823 parataxis hg,HG
R6787 T21826 T21825 compound hg,hg
R6788 T21827 T21825 punct /,hg
R6789 T21828 T21825 punct ),hg
R679 T3224 T3217 advcl implying,forms
R6790 T21829 T21815 cc and,B6
R6791 T21830 T21815 conj heterozygous,B6
R6792 T21831 T21800 punct .,backcrossed
R6793 T21833 T21834 det These,mice
R6794 T21834 T21835 nsubjpass mice,intermated
R6795 T21836 T21835 auxpass were,intermated
R6796 T21837 T21838 aux to,produce
R6797 T21838 T21835 advcl produce,intermated
R6798 T21839 T21840 amod homozygous,founders
R6799 T21840 T21838 dobj founders,produce
R680 T3140 T3137 prep in,number
R6800 T21841 T21838 prep for,produce
R6801 T21842 T21843 det each,strain
R6802 T21843 T21841 pobj strain,for
R6803 T21844 T21835 punct .,intermated
R6804 T21846 T21847 det This,scheme
R6805 T21847 T21850 nsubj scheme,created
R6806 T21848 T21847 amod novel,scheme
R6807 T21849 T21847 amod breeding,scheme
R6808 T21851 T21852 nummod four,congenics
R6809 T21852 T21850 dobj congenics,created
R681 T3225 T3226 mark that,are
R6810 T21853 T21852 amod identical,congenics
R6811 T21854 T21852 compound founder,congenics
R6812 T21855 T21852 prep on,congenics
R6813 T21856 T21857 nummod two,backgrounds
R6814 T21857 T21855 pobj backgrounds,on
R6815 T21858 T21857 appos B6,backgrounds
R6816 T21859 T21860 punct (,+
R6817 T21860 T21858 punct +,B6
R6818 T21861 T21860 punct +,+
R6819 T21862 T21860 punct /,+
R682 T3226 T3224 ccomp are,implying
R6820 T21863 T21860 punct ),+
R6821 T21864 T21858 cc and,B6
R6822 T21865 T21858 conj HG,B6
R6823 T21866 T21867 punct (,hg
R6824 T21867 T21865 parataxis hg,HG
R6825 T21868 T21867 compound hg,hg
R6826 T21869 T21867 punct /,hg
R6827 T21870 T21867 punct ),hg
R6828 T21871 T21857 punct ", ",backgrounds
R6829 T21872 T21873 dep which,formed
R683 T3141 T3140 pobj common,in
R6830 T21873 T21857 relcl formed,backgrounds
R6831 T21874 T21875 det the,basis
R6832 T21875 T21873 dobj basis,formed
R6833 T21876 T21875 prep for,basis
R6834 T21877 T21878 poss our,examination
R6835 T21878 T21876 pobj examination,for
R6836 T21879 T21878 prep of,examination
R6837 T21880 T21879 pobj interactions,of
R6838 T21881 T21880 acl caused,interactions
R6839 T21882 T21881 agent by,caused
R684 T3227 T3228 det the,gene
R6840 T21883 T21884 det the,presence
R6841 T21884 T21882 pobj presence,by
R6842 T21885 T21884 prep of,presence
R6843 T21886 T21887 det the,deletion
R6844 T21887 T21885 pobj deletion,of
R6845 T21888 T21887 compound hg,deletion
R6846 T21889 T21850 punct .,created
R6847 T21891 T21892 nmod MMU2,strains
R6848 T21892 T21895 nsubjpass strains,maintained
R6849 T21893 T21894 npadvmod speed,congenic
R685 T3228 T3226 nsubj gene,are
R6850 T21894 T21892 amod congenic,strains
R6851 T21896 T21895 auxpass were,maintained
R6852 T21897 T21895 prep through,maintained
R6853 T21898 T21899 compound brother,sister
R6854 T21899 T21901 compound sister,mating
R6855 T21900 T21899 punct -,sister
R6856 T21901 T21897 pobj mating,through
R6857 T21902 T21895 punct .,maintained
R6858 T21904 T21905 advmod Once,stabilized
R6859 T21905 T21909 advcl stabilized,used
R686 T3229 T3228 amod known,gene
R6860 T21906 T21907 det each,congenic
R6861 T21907 T21905 nsubjpass congenic,stabilized
R6862 T21908 T21905 auxpass was,stabilized
R6863 T21910 T21909 punct ", ",used
R6864 T21911 T21912 nummod 20,markers
R6865 T21912 T21909 nsubjpass markers,used
R6866 T21913 T21912 amod additional,markers
R6867 T21914 T21912 compound microsatellite,markers
R6868 T21915 T21909 auxpass were,used
R6869 T21916 T21917 aux to,refine
R687 T3230 T3228 cc and,gene
R6870 T21917 T21909 advcl refine,used
R6871 T21918 T21919 det the,position
R6872 T21919 T21917 dobj position,refine
R6873 T21920 T21919 prep of,position
R6874 T21921 T21922 det each,point
R6875 T21922 T21920 pobj point,of
R6876 T21923 T21922 amod congenic,point
R6877 T21924 T21922 amod recombinant,point
R6878 T21925 T21922 compound end,point
R6879 T21926 T21927 punct (,File
R688 T3142 T3141 prep with,common
R6880 T21927 T21909 parataxis File,used
R6881 T21928 T21927 amod Additional,File
R6882 T21929 T21927 nummod 2,File
R6883 T21930 T21927 punct ),File
R6884 T21931 T21909 punct .,used
R6885 T22599 T22598 prep of,Development
R6886 T22600 T22601 nmod HG.CAST,strains
R6887 T22601 T22599 pobj strains,of
R6888 T22602 T22603 npadvmod speed,congenic
R6889 T22603 T22601 amod congenic,strains
R689 T3231 T3232 poss its,modifiers
R6890 T22604 T22601 prep for,strains
R6891 T22605 T22606 nmod MMU,1
R6892 T22606 T22604 pobj 1,for
R6893 T22607 T22606 punct ", ",1
R6894 T22608 T22606 conj 5,1
R6895 T22609 T22608 punct ", ",5
R6896 T22610 T22608 conj 8,5
R6897 T22611 T22610 punct ", ",8
R6898 T22612 T22610 conj 9,8
R6899 T22613 T22612 punct ", ",9
R690 T3232 T3228 conj modifiers,gene
R6900 T22614 T22612 conj 11,9
R6901 T22615 T22614 cc and,11
R6902 T22616 T22614 conj 17,11
R6903 T22618 T22619 det All,males
R6904 T22619 T22622 nsubjpass males,genotyped
R6905 T22620 T22619 amod black,males
R6906 T22621 T22619 compound N2,males
R6907 T22623 T22619 prep from,males
R6908 T22624 T22625 det the,crosses
R6909 T22625 T22623 pobj crosses,from
R691 T3143 T3142 pobj HG,with
R6910 T22626 T22625 amod first,crosses
R6911 T22627 T22625 nummod two,crosses
R6912 T22628 T22625 acl described,crosses
R6913 T22629 T22628 advmod above,described
R6914 T22630 T22622 auxpass were,genotyped
R6915 T22631 T22622 prep for,genotyped
R6916 T22632 T22633 nummod 12,markers
R6917 T22633 T22631 pobj markers,for
R6918 T22634 T22633 punct (,markers
R6919 T22635 T22633 appos D1Mit432,markers
R692 T3233 T3226 attr members,are
R6920 T22636 T22635 punct ", ",D1Mit432
R6921 T22637 T22638 punct -,480
R6922 T22638 T22635 conj 480,D1Mit432
R6923 T22639 T22638 punct ", ",480
R6924 T22640 T22638 conj D5Mit353,480
R6925 T22641 T22640 punct ", ",D5Mit353
R6926 T22642 T22643 punct -,311
R6927 T22643 T22640 conj 311,D5Mit353
R6928 T22644 T22643 punct ", ",311
R6929 T22645 T22643 conj D9Mit60,311
R693 T3234 T3233 prep of,members
R6930 T22646 T22645 punct ", ",D9Mit60
R6931 T22647 T22648 punct -,262
R6932 T22648 T22645 conj 262,D9Mit60
R6933 T22649 T22648 punct ", ",262
R6934 T22650 T22648 conj D11Mit5,262
R6935 T22651 T22650 punct ", ",D11Mit5
R6936 T22652 T22653 punct -,67
R6937 T22653 T22650 conj 67,D11Mit5
R6938 T22654 T22653 punct ", ",67
R6939 T22655 T22653 conj D8Mit234,67
R694 T3144 T3137 punct ", ",number
R6940 T22656 T22655 punct ", ",D8Mit234
R6941 T22657 T22658 punct -,211
R6942 T22658 T22655 conj 211,D8Mit234
R6943 T22659 T22658 cc and,211
R6944 T22660 T22658 conj D17Mit28,211
R6945 T22661 T22660 cc and,D17Mit28
R6946 T22662 T22663 punct -,142
R6947 T22663 T22660 conj 142,D17Mit28
R6948 T22664 T22633 punct ),markers
R6949 T22665 T22633 punct ", ",markers
R695 T3235 T3236 det the,pathway
R6950 T22666 T22633 appos two,markers
R6951 T22667 T22666 acl spanning,two
R6952 T22668 T22667 dobj each,spanning
R6953 T22669 T22668 prep of,each
R6954 T22670 T22671 det the,regions
R6955 T22671 T22669 pobj regions,of
R6956 T22672 T22671 nummod six,regions
R6957 T22673 T22674 npadvmod QTL,harboring
R6958 T22674 T22671 amod harboring,regions
R6959 T22675 T22671 punct (,regions
R696 T3236 T3234 pobj pathway,of
R6960 T22676 T22677 nmod MMU,1
R6961 T22677 T22671 appos 1,regions
R6962 T22678 T22677 punct ", ",1
R6963 T22679 T22677 conj 5,1
R6964 T22680 T22679 punct ", ",5
R6965 T22681 T22679 conj 8,5
R6966 T22682 T22681 punct ", ",8
R6967 T22683 T22681 conj 9,8
R6968 T22684 T22683 punct ", ",9
R6969 T22685 T22683 conj 11,9
R697 T3237 T3236 amod same,pathway
R6970 T22686 T22685 cc and,11
R6971 T22687 T22685 conj 17,11
R6972 T22688 T22689 punct ;,Table
R6973 T22689 T22622 parataxis Table,genotyped
R6974 T22690 T22689 nummod 1,Table
R6975 T22691 T22689 cc and,Table
R6976 T22692 T22693 amod Additional,File
R6977 T22693 T22689 conj File,Table
R6978 T22694 T22693 nummod 1,File
R6979 T22695 T22689 punct ),Table
R698 T3238 T3236 amod biochemical,pathway
R6980 T22696 T22622 punct .,genotyped
R6981 T22698 T22699 nsubjpass Markers,selected
R6982 T22700 T22699 auxpass were,selected
R6983 T22701 T22702 aux to,capture
R6984 T22702 T22699 advcl capture,selected
R6985 T22703 T22702 punct ", ",capture
R6986 T22704 T22702 prep at,capture
R6987 T22705 T22706 det a,minimum
R6988 T22706 T22704 pobj minimum,at
R6989 T22707 T22702 punct ", ",capture
R699 T3239 T3238 cc or,biochemical
R6990 T22708 T22709 det the,interval
R6991 T22709 T22702 dobj interval,capture
R6992 T22710 T22711 nummod 2,LOD
R6993 T22711 T22709 compound LOD,interval
R6994 T22712 T22711 punct -,LOD
R6995 T22713 T22709 compound support,interval
R6996 T22714 T22699 punct .,selected
R6997 T22716 T22717 nummod Two,males
R6998 T22717 T22719 nsubjpass males,selected
R6999 T22718 T22717 compound N2,males
R700 T3240 T3238 conj metabolic,biochemical
R7000 T22720 T22719 auxpass were,selected
R7001 T22721 T22722 aux to,propagate
R7002 T22722 T22719 xcomp propagate,selected
R7003 T22723 T22724 det the,generation
R7004 T22724 T22722 dobj generation,propagate
R7005 T22725 T22724 compound N3,generation
R7006 T22726 T22719 punct ;,selected
R7007 T22727 T22719 dobj one,selected
R7008 T22728 T22727 amod heterozygous,one
R7009 T22729 T22728 prep for,heterozygous
R701 T3241 T3217 punct .,forms
R7010 T22730 T22729 pobj QTL,for
R7011 T22731 T22730 prep on,QTL
R7012 T22732 T22733 nmod MMU,1
R7013 T22733 T22731 pobj 1,on
R7014 T22734 T22733 cc and,1
R7015 T22735 T22733 conj 9,1
R7016 T22736 T22727 cc and,one
R7017 T22737 T22738 det the,other
R7018 T22738 T22727 conj other,one
R7019 T22739 T22738 amod heterozygous,other
R702 T3145 T3137 prep including,number
R7020 T22740 T22739 prep for,heterozygous
R7021 T22741 T22740 pobj QTL,for
R7022 T22742 T22741 prep on,QTL
R7023 T22743 T22744 nmod MMU,5
R7024 T22744 T22742 pobj 5,on
R7025 T22745 T22744 punct ", ",5
R7026 T22746 T22744 conj 8,5
R7027 T22747 T22746 punct ", ",8
R7028 T22748 T22746 conj 11,8
R7029 T22749 T22748 cc and,11
R703 T3243 T3244 amod Different,backgrounds
R7030 T22750 T22748 conj 17,11
R7031 T22751 T22752 punct (,Figure
R7032 T22752 T22719 parataxis Figure,selected
R7033 T22753 T22752 nummod 1,Figure
R7034 T22754 T22752 punct ),Figure
R7035 T22755 T22719 punct .,selected
R7036 T22757 T22758 det Both,males
R7037 T22758 T22759 nsubj males,were
R7038 T22760 T22759 acomp homozygous,were
R7039 T22761 T22760 prep for,homozygous
R704 T3244 T3246 nsubjpass backgrounds,shown
R7040 T22762 T22763 compound HG,alleles
R7041 T22763 T22761 pobj alleles,for
R7042 T22764 T22759 prep at,were
R7043 T22765 T22766 det all,QTL
R7044 T22766 T22764 pobj QTL,at
R7045 T22767 T22766 amod other,QTL
R7046 T22768 T22766 amod known,QTL
R7047 T22769 T22759 punct .,were
R7048 T22771 T22772 det These,males
R7049 T22772 T22773 nsubjpass males,backcrossed
R705 T3245 T3244 amod genetic,backgrounds
R7050 T22774 T22773 auxpass were,backcrossed
R7051 T22775 T22773 prep to,backcrossed
R7052 T22776 T22777 compound HG,females
R7053 T22777 T22775 pobj females,to
R7054 T22778 T22773 cc and,backcrossed
R7055 T22779 T22780 nsubjpass two,selected
R7056 T22780 T22773 conj selected,backcrossed
R7057 T22781 T22779 prep of,two
R7058 T22782 T22783 det the,males
R7059 T22783 T22781 pobj males,of
R706 T3146 T3145 pobj gigantism,including
R7060 T22784 T22783 amod resulting,males
R7061 T22785 T22783 compound N3,males
R7062 T22786 T22783 acl inheriting,males
R7063 T22787 T22788 det the,sets
R7064 T22788 T22786 dobj sets,inheriting
R7065 T22789 T22788 amod same,sets
R7066 T22790 T22788 prep of,sets
R7067 T22791 T22790 pobj QTL,of
R7068 T22792 T22788 prep as,sets
R7069 T22793 T22794 poss their,sire
R707 T3247 T3246 aux have,shown
R7070 T22794 T22792 pobj sire,as
R7071 T22795 T22780 auxpass were,selected
R7072 T22796 T22780 prep for,selected
R7073 T22797 T22796 pobj breeding,for
R7074 T22798 T22780 punct .,selected
R7075 T22800 T22801 det These,males
R7076 T22801 T22802 nsubjpass males,backcrossed
R7077 T22803 T22802 auxpass were,backcrossed
R7078 T22804 T22802 advmod subsequently,backcrossed
R7079 T22805 T22802 prep to,backcrossed
R708 T3248 T3246 auxpass been,shown
R7080 T22806 T22807 compound HG,females
R7081 T22807 T22805 pobj females,to
R7082 T22808 T22802 cc and,backcrossed
R7083 T22809 T22810 nummod three,males
R7084 T22810 T22812 nsubjpass males,identified
R7085 T22811 T22810 compound N4,males
R7086 T22812 T22802 conj identified,backcrossed
R7087 T22813 T22812 auxpass were,identified
R7088 T22814 T22812 acomp heterozygous,identified
R7089 T22815 T22814 prep for,heterozygous
R709 T3147 T3148 punct [,17
R7090 T22816 T22817 det the,regions
R7091 T22817 T22815 pobj regions,for
R7092 T22818 T22817 amod following,regions
R7093 T22819 T22817 punct : ,regions
R7094 T22820 T22821 meta 1,1
R7095 T22821 T22817 appos 1,regions
R7096 T22822 T22820 punct ),1
R7097 T22823 T22821 nmod MMU,1
R7098 T22824 T22821 cc and,1
R7099 T22825 T22821 conj 9,1
R710 T3249 T3250 aux to,modify
R7100 T22826 T22821 punct ;,1
R7101 T22827 T22828 meta 2,5
R7102 T22828 T22821 appos 5,1
R7103 T22829 T22827 punct ),2
R7104 T22830 T22828 nmod MMU,5
R7105 T22831 T22828 cc and,5
R7106 T22832 T22828 conj 11,5
R7107 T22833 T22821 punct ;,1
R7108 T22834 T22835 meta 3,8
R7109 T22835 T22821 appos 8,1
R711 T3148 T3116 parataxis 17,confirmed
R7110 T22836 T22834 punct ),3
R7111 T22837 T22835 nmod MMU,8
R7112 T22838 T22835 punct ", ",8
R7113 T22839 T22835 conj 11,8
R7114 T22840 T22839 cc and,11
R7115 T22841 T22839 conj 17,11
R7116 T22842 T22843 punct (,Figure
R7117 T22843 T22812 parataxis Figure,identified
R7118 T22844 T22843 nummod 1,Figure
R7119 T22845 T22843 punct ),Figure
R712 T3250 T3246 xcomp modify,shown
R7120 T22846 T22812 punct .,identified
R7121 T22848 T22849 advcl Starting,selected
R7122 T22850 T22848 prep at,Starting
R7123 T22851 T22850 pobj N4,at
R7124 T22852 T22848 cc and,Starting
R7125 T22853 T22848 conj continuing,Starting
R7126 T22854 T22853 prep through,continuing
R7127 T22855 T22854 pobj N6,through
R7128 T22856 T22849 punct ", ",selected
R7129 T22857 T22858 det the,male
R713 T3251 T3252 det the,effects
R7130 T22858 T22849 nsubjpass male,selected
R7131 T22859 T22858 punct """",male
R7132 T22860 T22858 amod best,male
R7133 T22861 T22858 punct """",male
R7134 T22862 T22858 prep with,male
R7135 T22863 T22864 det the,percent
R7136 T22864 T22862 pobj percent,with
R7137 T22865 T22864 amod lowest,percent
R7138 T22866 T22864 prep of,percent
R7139 T22867 T22868 amod unwanted,alleles
R714 T3252 T3250 dobj effects,modify
R7140 T22868 T22866 pobj alleles,of
R7141 T22869 T22868 compound donor,alleles
R7142 T22870 T22849 auxpass was,selected
R7143 T22871 T22849 prep after,selected
R7144 T22872 T22871 pcomp performing,after
R7145 T22873 T22874 det a,scan
R7146 T22874 T22872 dobj scan,performing
R7147 T22875 T22874 compound genome,scan
R7148 T22876 T22872 advcl using,performing
R7149 T22877 T22878 det the,markers
R715 T3149 T3148 punct ],17
R7150 T22878 T22876 dobj markers,using
R7151 T22879 T22878 amod remaining,markers
R7152 T22880 T22878 nummod 67,markers
R7153 T22881 T22882 npadvmod genome,wide
R7154 T22882 T22878 amod wide,markers
R7155 T22883 T22882 punct -,wide
R7156 T22884 T22885 punct (,markers
R7157 T22885 T22878 parataxis markers,markers
R7158 T22886 T22885 nummod 79,markers
R7159 T22887 T22885 amod total,markers
R716 T3253 T3254 npadvmod growth,enhancing
R7160 T22888 T22885 cc minus,markers
R7161 T22889 T22890 det the,markers
R7162 T22890 T22885 conj markers,markers
R7163 T22891 T22890 nummod 12,markers
R7164 T22892 T22890 acl genotyped,markers
R7165 T22893 T22892 prep in,genotyped
R7166 T22894 T22895 det the,backcrosses
R7167 T22895 T22893 pobj backcrosses,in
R7168 T22896 T22895 amod first,backcrosses
R7169 T22897 T22895 nummod two,backcrosses
R717 T3254 T3252 amod enhancing,effects
R7170 T22898 T22895 acl spanning,backcrosses
R7171 T22899 T22900 det the,intervals
R7172 T22900 T22898 dobj intervals,spanning
R7173 T22901 T22900 amod know,intervals
R7174 T22902 T22900 compound QTL,intervals
R7175 T22903 T22885 punct ),markers
R7176 T22904 T22849 punct .,selected
R7177 T22906 T22907 prep At,created
R7178 T22908 T22906 pobj N5,At
R7179 T22909 T22910 det a,strain
R718 T3255 T3254 punct -,enhancing
R7180 T22910 T22907 nsubjpass strain,created
R7181 T22911 T22910 amod distinct,strain
R7182 T22912 T22907 auxpass was,created
R7183 T22913 T22907 prep for,created
R7184 T22914 T22913 pobj each,for
R7185 T22915 T22914 prep of,each
R7186 T22916 T22917 det the,regions
R7187 T22917 T22915 pobj regions,of
R7188 T22918 T22917 nummod six,regions
R7189 T22919 T22917 amod individual,regions
R719 T3150 T3116 punct .,confirmed
R7190 T22920 T22917 compound donor,regions
R7191 T22921 T22907 cc and,created
R7192 T22922 T22923 amod heterozygous,mice
R7193 T22923 T22924 nsubjpass mice,intermated
R7194 T22924 T22907 conj intermated,created
R7195 T22925 T22924 auxpass were,intermated
R7196 T22926 T22927 punct (,Figure
R7197 T22927 T22907 parataxis Figure,created
R7198 T22928 T22927 nummod 1,Figure
R7199 T22929 T22927 punct ),Figure
R720 T3256 T3252 prep of,effects
R7200 T22930 T22907 punct .,created
R7201 T22932 T22933 amod Homozygous,strains
R7202 T22933 T22937 nsubjpass strains,maintained
R7203 T22934 T22933 nmod HG.CAST,strains
R7204 T22935 T22936 npadvmod speed,congenic
R7205 T22936 T22933 amod congenic,strains
R7206 T22938 T22937 auxpass were,maintained
R7207 T22939 T22937 prep through,maintained
R7208 T22940 T22941 compound brother,sister
R7209 T22941 T22943 compound sister,mating
R721 T3257 T3256 pobj hg,of
R7210 T22942 T22941 punct -,sister
R7211 T22943 T22939 pobj mating,through
R7212 T22944 T22937 punct .,maintained
R7213 T22946 T22947 mark Once,stabilized
R7214 T22947 T22951 advcl stabilized,used
R7215 T22948 T22949 det each,congenic
R7216 T22949 T22947 nsubjpass congenic,stabilized
R7217 T22950 T22947 auxpass was,stabilized
R7218 T22952 T22951 punct ", ",used
R7219 T22953 T22954 nummod 19,markers
R722 T3258 T3259 punct [,22
R7220 T22954 T22951 nsubjpass markers,used
R7221 T22955 T22954 amod additional,markers
R7222 T22956 T22954 compound microsatellite,markers
R7223 T22957 T22951 auxpass were,used
R7224 T22958 T22959 aux to,refine
R7225 T22959 T22951 advcl refine,used
R7226 T22960 T22961 det the,position
R7227 T22961 T22959 dobj position,refine
R7228 T22962 T22961 prep of,position
R7229 T22963 T22964 det each,point
R723 T3259 T3246 parataxis 22,shown
R7230 T22964 T22962 pobj point,of
R7231 T22965 T22964 amod congenic,point
R7232 T22966 T22964 amod recombinant,point
R7233 T22967 T22964 compound end,point
R7234 T22968 T22969 punct (,File
R7235 T22969 T22951 parataxis File,used
R7236 T22970 T22969 amod Additional,File
R7237 T22971 T22969 nummod 2,File
R7238 T22972 T22969 punct ),File
R7239 T22973 T22951 punct .,used
R724 T3152 T3153 nsubjpass QTL,referred
R7240 T23421 T23420 prep of,Development
R7241 T23422 T23423 nmod B6.CASTC,strains
R7242 T23423 T23421 pobj strains,of
R7243 T23424 T23422 cc and,B6.CASTC
R7244 T23425 T23422 conj HG.CASTC,B6.CASTC
R7245 T23426 T23423 compound control,strains
R7246 T23428 T23429 nsubj HG,is
R7247 T23429 T23430 ccomp is,be
R7248 T23431 T23432 det a,strain
R7249 T23432 T23429 attr strain,is
R725 T3260 T3259 nummod 15,22
R7250 T23433 T23434 prep in,introgressed
R7251 T23434 T23432 relcl introgressed,strain
R7252 T23435 T23433 pobj which,in
R7253 T23436 T23437 det the,deletion
R7254 T23437 T23434 nsubjpass deletion,introgressed
R7255 T23438 T23437 compound hg,deletion
R7256 T23439 T23434 aux has,introgressed
R7257 T23440 T23434 auxpass been,introgressed
R7258 T23441 T23434 prep onto,introgressed
R7259 T23442 T23443 det a,background
R726 T3261 T3259 punct ",",22
R7260 T23443 T23441 pobj background,onto
R7261 T23444 T23443 compound B6,background
R7262 T23445 T23430 punct ", ",be
R7263 T23446 T23430 advmod therefore,be
R7264 T23447 T23448 det the,differences
R7265 T23448 T23430 nsubj differences,be
R7266 T23449 T23448 amod only,differences
R7267 T23450 T23448 amod genetic,differences
R7268 T23451 T23448 prep between,differences
R7269 T23452 T23453 det the,strains
R727 T3262 T3259 punct ],22
R7270 T23453 T23451 pobj strains,between
R7271 T23454 T23430 aux would,be
R7272 T23455 T23456 det the,locus
R7273 T23456 T23430 attr locus,be
R7274 T23457 T23456 compound hg,locus
R7275 T23458 T23456 punct ", ",locus
R7276 T23459 T23460 advmod tightly,linked
R7277 T23460 T23461 amod linked,alleles
R7278 T23461 T23456 conj alleles,locus
R7279 T23462 T23461 prep from,alleles
R728 T3154 T3155 dep which,alter
R7280 T23463 T23464 det the,strain
R7281 T23464 T23462 pobj strain,from
R7282 T23465 T23464 amod outbred,strain
R7283 T23466 T23467 prep on,arose
R7284 T23467 T23464 relcl arose,strain
R7285 T23468 T23466 pobj which,on
R7286 T23469 T23467 nsubj hg,arose
R7287 T23470 T23461 cc and,alleles
R7288 T23471 T23472 amod contaminating,alleles
R7289 T23472 T23461 conj alleles,alleles
R729 T3263 T3246 punct .,shown
R7290 T23473 T23472 acl remaining,alleles
R7291 T23474 T23473 prep after,remaining
R7292 T23475 T23476 det the,backcrosses
R7293 T23476 T23474 pobj backcrosses,after
R7294 T23477 T23476 nummod nine,backcrosses
R7295 T23478 T23473 cc and,remaining
R7296 T23479 T23473 conj fixed,remaining
R7297 T23480 T23479 prep during,fixed
R7298 T23481 T23480 pobj inbreeding,during
R7299 T23482 T23430 punct .,be
R730 T3265 T3266 mark Since,is
R7300 T23484 T23485 advmod Instead,of
R7301 T23485 T23486 prep of,choose
R7302 T23487 T23485 pcomp using,of
R7303 T23488 T23489 amod parental,strains
R7304 T23489 T23487 dobj strains,using
R7305 T23490 T23489 nmod B6,strains
R7306 T23491 T23490 cc and,B6
R7307 T23492 T23490 conj HG,B6
R7308 T23493 T23487 prep as,using
R7309 T23494 T23493 pobj controls,as
R731 T3266 T3272 advcl is,is
R7310 T23495 T23494 prep for,controls
R7311 T23496 T23497 amod phenotypic,comparisons
R7312 T23497 T23495 pobj comparisons,for
R7313 T23498 T23497 prep with,comparisons
R7314 T23499 T23500 det each,speed
R7315 T23500 T23498 pobj speed,with
R7316 T23501 T23500 amod congenic,speed
R7317 T23502 T23486 punct ", ",choose
R7318 T23503 T23486 nsubj we,choose
R7319 T23504 T23505 aux to,develop
R732 T3267 T3268 det the,function
R7320 T23505 T23486 xcomp develop,choose
R7321 T23506 T23507 amod independent,strains
R7322 T23507 T23505 dobj strains,develop
R7323 T23508 T23507 compound control,strains
R7324 T23509 T23507 acl originating,strains
R7325 T23510 T23509 prep from,originating
R7326 T23511 T23512 det the,cross
R7327 T23512 T23510 pobj cross,from
R7328 T23513 T23512 amod same,cross
R7329 T23514 T23512 prep as,cross
R733 T3155 T3152 relcl alter,QTL
R7330 T23515 T23516 det the,panels
R7331 T23516 T23514 pobj panels,as
R7332 T23517 T23516 amod congenic,panels
R7333 T23518 T23486 punct .,choose
R7334 T23520 T23521 amod Separate,strains
R7335 T23521 T23533 nsubjpass strains,developed
R7336 T23522 T23523 nmod B6.CAST,control
R7337 T23523 T23521 nmod control,strains
R7338 T23524 T23523 punct (,control
R7339 T23525 T23523 appos B6C,control
R734 T3268 T3266 nsubj function,is
R7340 T23526 T23523 punct ),control
R7341 T23527 T23523 cc and,control
R7342 T23528 T23529 compound HG.CAST,control
R7343 T23529 T23523 conj control,control
R7344 T23530 T23529 punct (,control
R7345 T23531 T23529 appos HGC,control
R7346 T23532 T23521 punct ),strains
R7347 T23534 T23533 auxpass were,developed
R7348 T23535 T23533 advcl using,developed
R7349 T23536 T23535 dobj mice,using
R735 T3269 T3268 amod primary,function
R7350 T23537 T23536 prep from,mice
R7351 T23538 T23539 det the,experiment
R7352 T23539 T23537 pobj experiment,from
R7353 T23540 T23539 compound MMU2,experiment
R7354 T23541 T23533 punct .,developed
R7355 T23543 T23544 nsubjpass Mice,intermated
R7356 T23545 T23543 prep from,Mice
R7357 T23546 T23547 det the,backcross
R7358 T23547 T23545 pobj backcross,from
R7359 T23548 T23547 amod last,backcross
R736 T3270 T3268 prep of,function
R7360 T23549 T23543 acl inheriting,Mice
R7361 T23550 T23551 advmod only,alleles
R7362 T23551 T23549 dobj alleles,inheriting
R7363 T23552 T23551 nmod B6,alleles
R7364 T23553 T23552 cc or,B6
R7365 T23554 T23552 conj HG,B6
R7366 T23555 T23551 compound MMU2,alleles
R7367 T23556 T23549 prep at,inheriting
R7368 T23557 T23556 pobj markers,at
R7369 T23558 T23557 acl spanning,markers
R737 T3156 T3157 det the,effects
R7370 T23559 T23558 dobj MMU2,spanning
R7371 T23560 T23544 auxpass were,intermated
R7372 T23561 T23562 aux to,serve
R7373 T23562 T23544 advcl serve,intermated
R7374 T23563 T23562 prep as,serve
R7375 T23564 T23565 det the,basis
R7376 T23565 T23563 pobj basis,as
R7377 T23566 T23565 prep for,basis
R7378 T23567 T23568 det each,control
R7379 T23568 T23566 pobj control,for
R738 T3271 T3270 pobj Socs2,of
R7380 T23569 T23544 punct .,intermated
R7381 T23571 T23572 det Both,strains
R7382 T23572 T23574 nsubjpass strains,maintained
R7383 T23573 T23572 compound control,strains
R7384 T23575 T23574 auxpass were,maintained
R7385 T23576 T23574 advmod subsequently,maintained
R7386 T23577 T23574 prep through,maintained
R7387 T23578 T23579 compound brother,sister
R7388 T23579 T23581 compound sister,mating
R7389 T23580 T23579 punct -,sister
R739 T3157 T3155 dobj effects,alter
R7390 T23581 T23577 pobj mating,through
R7391 T23582 T23574 punct .,maintained
R7392 T23584 T23585 det The,strains
R7393 T23585 T23587 nsubj strains,were
R7394 T23586 T23585 compound control,strains
R7395 T23588 T23587 acomp coisogenic,were
R7396 T23589 T23588 prep with,coisogenic
R7397 T23590 T23591 det the,strain
R7398 T23591 T23589 pobj strain,with
R7399 T23592 T23591 amod parental,strain
R740 T3273 T3274 aux to,regulate
R7400 T23593 T23591 nmod B6,strain
R7401 T23594 T23593 cc or,B6
R7402 T23595 T23593 conj HG,B6
R7403 T23596 T23587 prep with,were
R7404 T23597 T23598 det the,exception
R7405 T23598 T23596 pobj exception,with
R7406 T23599 T23598 prep of,exception
R7407 T23600 T23599 pobj mutations,of
R7408 T23601 T23602 dep that,arose
R7409 T23602 T23600 relcl arose,mutations
R741 T3274 T3266 xcomp regulate,is
R7410 T23603 T23602 prep during,arose
R7411 T23604 T23605 amod congenic,construction
R7412 T23605 T23603 pobj construction,during
R7413 T23606 T23600 cc and,mutations
R7414 T23607 T23608 det a,percentage
R7415 T23608 T23600 conj percentage,mutations
R7416 T23609 T23608 amod small,percentage
R7417 T23610 T23608 prep of,percentage
R7418 T23611 T23612 amod contaminating,alleles
R7419 T23612 T23610 pobj alleles,of
R742 T3275 T3274 advmod negatively,regulate
R7420 T23613 T23612 compound donor,alleles
R7421 T23614 T23612 acl missed,alleles
R7422 T23615 T23614 prep after,missed
R7423 T23616 T23617 nummod 6,backcrosses
R7424 T23617 T23615 pobj backcrosses,after
R7425 T23618 T23587 punct .,were
R7426 T23620 T23621 advmod Therefore,are
R7427 T23622 T23621 punct ", ",are
R7428 T23623 T23624 mark since,developed
R7429 T23624 T23621 advcl developed,are
R743 T3276 T3277 compound growth,hormone
R7430 T23625 T23626 det the,congenics
R7431 T23626 T23624 nsubjpass congenics,developed
R7432 T23627 T23626 cc and,congenics
R7433 T23628 T23626 conj controls,congenics
R7434 T23629 T23624 auxpass were,developed
R7435 T23630 T23624 prep through,developed
R7436 T23631 T23632 det the,scheme
R7437 T23632 T23630 pobj scheme,through
R7438 T23633 T23632 amod same,scheme
R7439 T23634 T23632 compound selection,scheme
R744 T3158 T3157 amod phenotypic,effects
R7440 T23635 T23624 cc and,developed
R7441 T23636 T23637 advmod possibly,share
R7442 T23637 T23624 conj share,developed
R7443 T23638 T23639 amod common,regions
R7444 T23639 T23637 dobj regions,share
R7445 T23640 T23639 amod contaminating,regions
R7446 T23641 T23621 punct ", ",are
R7447 T23642 T23643 det the,strains
R7448 T23643 T23621 nsubj strains,are
R7449 T23644 T23643 nmod B6C,strains
R745 T3277 T3274 dobj hormone,regulate
R7450 T23645 T23644 cc and,B6C
R7451 T23646 T23644 conj HGC,B6C
R7452 T23647 T23648 det the,control
R7453 T23648 T23621 attr control,are
R7454 T23649 T23648 advmod most,control
R7455 T23650 T23648 amod ideal,control
R7456 T23651 T23652 aux to,compare
R7457 T23652 T23648 advcl compare,control
R7458 T23653 T23654 det each,congenic
R7459 T23654 T23652 dobj congenic,compare
R746 T3278 T3277 punct (,hormone
R7460 T23655 T23621 punct .,are
R7463 T24427 T24428 amod Phenotypic,characterization
R7464 T24430 T24431 compound Trait,data
R7465 T24431 T24432 nsubjpass data,collected
R7466 T24433 T24432 auxpass were,collected
R7467 T24434 T24432 prep on,collected
R7468 T24435 T24436 advmod approximately,40
R7469 T24436 T24437 nummod 40,mice
R747 T3159 T3157 prep of,effects
R7470 T24437 T24434 pobj mice,on
R7471 T24438 T24439 punct (,20
R7472 T24439 T24437 parataxis 20,mice
R7473 T24440 T24439 prep of,20
R7474 T24441 T24442 det each,sex
R7475 T24442 T24440 pobj sex,of
R7476 T24443 T24439 punct ),20
R7477 T24444 T24437 prep from,mice
R7478 T24445 T24446 det each,strain
R7479 T24446 T24444 pobj strain,from
R748 T3279 T3277 appos Gh,hormone
R7480 T24447 T24446 amod congenic,strain
R7481 T24448 T24447 cc and,congenic
R7482 T24449 T24447 conj control,congenic
R7483 T24450 T24432 punct .,collected
R7484 T24452 T24453 aux To,eliminate
R7485 T24453 T24454 advcl eliminate,characterized
R7486 T24455 T24453 dobj parity,eliminate
R7487 T24456 T24453 cc and,eliminate
R7488 T24457 T24453 conj reduce,eliminate
R7489 T24458 T24459 compound litter,size
R749 T3280 T3266 punct ),is
R7490 T24459 T24460 compound size,effects
R7491 T24460 T24457 dobj effects,reduce
R7492 T24461 T24462 advmod only,progeny
R7493 T24462 T24454 nsubjpass progeny,characterized
R7494 T24463 T24462 prep from,progeny
R7495 T24464 T24465 amod uniparous,dams
R7496 T24465 T24463 pobj dams,from
R7497 T24466 T24454 auxpass were,characterized
R7498 T24467 T24454 cc and,characterized
R7499 T24468 T24469 det all,litters
R750 T3281 T3282 punct [,23
R7500 T24469 T24470 nsubjpass litters,standardized
R7501 T24470 T24454 conj standardized,characterized
R7502 T24471 T24470 auxpass were,standardized
R7503 T24472 T24470 prep to,standardized
R7504 T24473 T24474 quantmod 5,7
R7505 T24474 T24476 nummod 7,pups
R7506 T24475 T24474 punct –,7
R7507 T24476 T24472 pobj pups,to
R7508 T24477 T24478 punct /,litter
R7509 T24478 T24476 prep litter,pups
R751 T3282 T3266 parataxis 23,is
R7510 T24479 T24470 punct .,standardized
R7511 T24481 T24482 nsubjpass Mice,weaned
R7512 T24483 T24482 auxpass were,weaned
R7513 T24484 T24482 prep at,weaned
R7514 T24485 T24486 nummod 3,weeks
R7515 T24486 T24484 pobj weeks,at
R7516 T24487 T24486 prep of,weeks
R7517 T24488 T24487 pobj age,of
R7518 T24489 T24482 punct .,weaned
R7519 T24491 T24492 nsubjpass Feed,offered
R752 T3160 T3161 det another,locus
R7520 T24493 T24494 punct (,protein
R7521 T24494 T24491 parataxis protein,Feed
R7522 T24495 T24494 dep Purina,protein
R7523 T24496 T24495 nummod 5008,Purina
R7524 T24497 T24494 punct ;,protein
R7525 T24498 T24499 nummod 23.5,%
R7526 T24499 T24494 compound %,protein
R7527 T24500 T24494 punct ", ",protein
R7528 T24501 T24502 nummod 6.5,%
R7529 T24502 T24503 compound %,fat
R753 T3283 T3282 punct ],23
R7530 T24503 T24494 appos fat,protein
R7531 T24504 T24494 punct ", ",protein
R7532 T24505 T24506 nummod 3.3,Kcal
R7533 T24506 T24494 appos Kcal,protein
R7534 T24507 T24508 punct /,g
R7535 T24508 T24506 prep g,Kcal
R7536 T24509 T24494 punct ),protein
R7537 T24510 T24491 cc and,Feed
R7538 T24511 T24491 conj water,Feed
R7539 T24512 T24492 auxpass were,offered
R754 T3284 T3272 punct ", ",is
R7540 T24513 T24514 advmod ad,libitum
R7541 T24514 T24492 advmod libitum,offered
R7542 T24515 T24492 punct .,offered
R7543 T24517 T24518 nsubjpass Mice,weighed
R7544 T24519 T24518 auxpass were,weighed
R7545 T24520 T24518 prep to,weighed
R7546 T24521 T24522 det the,g
R7547 T24522 T24520 pobj g,to
R7548 T24523 T24522 amod nearest,g
R7549 T24524 T24522 nummod 0.1,g
R755 T3285 T3272 nsubj it,is
R7550 T24525 T24518 prep at,weighed
R7551 T24526 T24525 pobj 2WK,at
R7552 T24527 T24526 punct ", ",2WK
R7553 T24528 T24526 conj 3WK,2WK
R7554 T24529 T24528 punct ", ",3WK
R7555 T24530 T24528 conj 6WK,3WK
R7556 T24531 T24530 punct ", ",6WK
R7557 T24532 T24530 cc and,6WK
R7558 T24533 T24530 conj 9WK,6WK
R7559 T24534 T24526 prep of,2WK
R756 T3161 T3159 pobj locus,of
R7560 T24535 T24534 pobj age,of
R7561 T24536 T24518 punct .,weighed
R7562 T24538 T24539 prep At,anesthetized
R7563 T24540 T24538 pobj 9WK,At
R7564 T24541 T24540 punct (,9WK
R7565 T24542 T24540 punct ±,9WK
R7566 T24543 T24544 nummod 5,days
R7567 T24544 T24540 appos days,9WK
R7568 T24545 T24540 punct ),9WK
R7569 T24546 T24539 nsubjpass mice,anesthetized
R757 T3286 T3272 acomp likely,is
R7570 T24547 T24539 auxpass were,anesthetized
R7571 T24548 T24539 prep under,anesthetized
R7572 T24549 T24548 pobj isoflurane,under
R7573 T24550 T24539 cc and,anesthetized
R7574 T24551 T24552 amod nasal,anal
R7575 T24552 T24554 amod anal,length
R7576 T24553 T24552 punct -,anal
R7577 T24554 T24555 nsubjpass length,measured
R7578 T24555 T24539 conj measured,anesthetized
R7579 T24556 T24554 punct (,length
R758 T3287 T3288 det these,effects
R7580 T24557 T24554 appos NA,length
R7581 T24558 T24554 punct ),length
R7582 T24559 T24554 cc and,length
R7583 T24560 T24561 amod nasal,tail
R7584 T24561 T24554 conj tail,length
R7585 T24562 T24561 punct -,tail
R7586 T24563 T24561 punct (,tail
R7587 T24564 T24561 appos NT,tail
R7588 T24565 T24555 punct ),measured
R7589 T24566 T24555 auxpass were,measured
R759 T3162 T3153 auxpass are,referred
R7590 T24567 T24555 prep to,measured
R7591 T24568 T24569 det the,mm
R7592 T24569 T24567 pobj mm,to
R7593 T24570 T24569 amod nearest,mm
R7594 T24571 T24539 punct .,anesthetized
R7595 T24573 T24574 compound Tail,length
R7596 T24574 T24575 nsubjpass length,calculated
R7597 T24576 T24575 auxpass was,calculated
R7598 T24577 T24575 prep as,calculated
R7599 T24578 T24577 pobj NA,as
R760 T3288 T3290 nsubj effects,are
R7600 T24579 T24578 cc minus,NA
R7601 T24580 T24578 conj NT,NA
R7602 T24581 T24575 punct .,calculated
R7603 T24583 T24584 amod Anesthetized,mice
R7604 T24584 T24585 nsubjpass mice,sacrificed
R7605 T24586 T24585 auxpass were,sacrificed
R7606 T24587 T24585 advmod then,sacrificed
R7607 T24588 T24585 prep by,sacrificed
R7608 T24589 T24588 pobj decapitation,by
R7609 T24590 T24585 cc and,sacrificed
R761 T3289 T3288 compound background,effects
R7610 T24591 T24585 conj exsanguinated,sacrificed
R7611 T24592 T24585 punct .,sacrificed
R7612 T24594 T24595 amod Femoral,pad
R7613 T24595 T24597 nsubjpass pad,removed
R7614 T24596 T24595 compound fat,pad
R7615 T24598 T24595 punct (,pad
R7616 T24599 T24595 appos FFP,pad
R7617 T24600 T24595 punct ),pad
R7618 T24601 T24595 punct ", ",pad
R7619 T24602 T24603 amod gonadal,pad
R762 T3163 T3153 prep to,referred
R7620 T24603 T24595 conj pad,pad
R7621 T24604 T24603 compound fat,pad
R7622 T24605 T24603 punct (,pad
R7623 T24606 T24603 appos GFP,pad
R7624 T24607 T24603 punct ),pad
R7625 T24608 T24603 punct ", ",pad
R7626 T24609 T24610 amod mesenteric,pad
R7627 T24610 T24603 conj pad,pad
R7628 T24611 T24610 compound fat,pad
R7629 T24612 T24610 punct (,pad
R763 T3290 T3286 advcl are,likely
R7630 T24613 T24610 appos MFP,pad
R7631 T24614 T24610 punct ),pad
R7632 T24615 T24610 cc and,pad
R7633 T24616 T24617 amod retroperitoneal,pad
R7634 T24617 T24610 conj pad,pad
R7635 T24618 T24617 compound fat,pad
R7636 T24619 T24617 punct (,pad
R7637 T24620 T24617 appos RFP,pad
R7638 T24621 T24597 punct ),removed
R7639 T24622 T24597 auxpass were,removed
R764 T3291 T3292 det the,result
R7640 T24623 T24597 cc and,removed
R7641 T24624 T24597 conj weighed,removed
R7642 T24625 T24624 prep to,weighed
R7643 T24626 T24627 det the,mg
R7644 T24627 T24625 pobj mg,to
R7645 T24628 T24627 amod nearest,mg
R7646 T24629 T24597 punct .,removed
R7647 T24631 T24632 amod Chemical,analysis
R7648 T24632 T24634 nsubjpass analysis,performed
R7649 T24633 T24632 amod compositional,analysis
R765 T3164 T3153 prep as,referred
R7650 T24635 T24634 auxpass was,performed
R7651 T24636 T24634 prep for,performed
R7652 T24637 T24638 nmod HGC,carcasses
R7653 T24638 T24636 pobj carcasses,for
R7654 T24639 T24637 punct ", ",HGC
R7655 T24640 T24637 conj HG11,HGC
R7656 T24641 T24640 cc and,HG11
R7657 T24642 T24640 conj HG17,HG11
R7658 T24643 T24644 mark as,described
R7659 T24644 T24634 advcl described,performed
R766 T3292 T3290 attr result,are
R7660 T24645 T24644 advmod previously,described
R7661 T24646 T24634 prep with,performed
R7662 T24647 T24648 amod slight,modifications
R7663 T24648 T24646 pobj modifications,with
R7664 T24649 T24650 punct [,24
R7665 T24650 T24634 parataxis 24,performed
R7666 T24651 T24650 punct ],24
R7667 T24652 T24634 punct .,performed
R7668 T24654 T24655 advmod Briefly,returned
R7669 T24656 T24655 punct ", ",returned
R767 T3293 T3292 prep of,result
R7670 T24657 T24655 prep after,returned
R7671 T24658 T24657 pobj weighing,after
R7672 T24659 T24660 det each,pad
R7673 T24660 T24655 nsubjpass pad,returned
R7674 T24661 T24660 compound fat,pad
R7675 T24662 T24655 auxpass was,returned
R7676 T24663 T24655 prep to,returned
R7677 T24664 T24665 det the,carcass
R7678 T24665 T24663 pobj carcass,to
R7679 T24666 T24655 punct .,returned
R768 T3294 T3295 nsubj polymorphism,influencing
R7680 T24668 T24669 det The,tract
R7681 T24669 T24675 nsubjpass tract,removed
R7682 T24670 T24669 amod entire,tract
R7683 T24671 T24669 amod gastrointestinal,tract
R7684 T24672 T24673 punct (,GI
R7685 T24673 T24669 parataxis GI,tract
R7686 T24674 T24673 punct ),GI
R7687 T24676 T24675 auxpass was,removed
R7688 T24677 T24675 advmod subsequently,removed
R7689 T24678 T24675 cc and,removed
R769 T3295 T3293 pcomp influencing,of
R7690 T24679 T24680 nsubjpass carcasses,weighed
R7691 T24680 T24675 conj weighed,removed
R7692 T24681 T24680 auxpass were,weighed
R7693 T24682 T24680 advmod again,weighed
R7694 T24683 T24680 punct .,weighed
R7695 T24685 T24686 nsubj This,represented
R7696 T24687 T24688 det the,weight
R7697 T24688 T24686 dobj weight,represented
R7698 T24689 T24690 amod empty,carcass
R7699 T24690 T24688 compound carcass,weight
R770 T3165 T3166 compound modifier,QTL
R7700 T24691 T24688 punct (,weight
R7701 T24692 T24688 appos ECW,weight
R7702 T24693 T24686 punct ),represented
R7703 T24694 T24686 punct .,represented
R7704 T24696 T24697 nsubjpass Carcasses,labeled
R7705 T24698 T24697 auxpass were,labeled
R7706 T24699 T24697 cc and,labeled
R7707 T24700 T24697 conj secured,labeled
R7708 T24701 T24700 prep in,secured
R7709 T24702 T24703 nummod two,layers
R771 T3296 T3295 dobj interactions,influencing
R7710 T24703 T24701 pobj layers,in
R7711 T24704 T24703 prep of,layers
R7712 T24705 T24704 pobj cheesecloth,of
R7713 T24706 T24707 punct (,Fisher
R7714 T24707 T24705 parataxis Fisher,cheesecloth
R7715 T24708 T24707 punct ),Fisher
R7716 T24709 T24700 cc and,secured
R7717 T24710 T24700 conj frozen,secured
R7718 T24711 T24710 prep at,frozen
R7719 T24712 T24713 punct -,20
R772 T3297 T3296 prep between,interactions
R7720 T24713 T24714 nummod 20,°C
R7721 T24714 T24711 pobj °C,at
R7722 T24715 T24710 prep until,frozen
R7723 T24716 T24715 pobj analysis,until
R7724 T24717 T24697 punct .,labeled
R7725 T24719 T24720 prep At,dried
R7726 T24721 T24722 det this,time
R7727 T24722 T24719 pobj time,At
R7728 T24723 T24720 punct ", ",dried
R7729 T24724 T24720 nsubjpass carcasses,dried
R773 T3298 T3297 pobj members,between
R7730 T24725 T24720 auxpass were,dried
R7731 T24726 T24720 dep freeze,dried
R7732 T24727 T24720 punct -,dried
R7733 T24728 T24720 prep for,dried
R7734 T24729 T24730 nummod seven,days
R7735 T24730 T24728 pobj days,for
R7736 T24731 T24720 cc and,dried
R7737 T24732 T24733 compound water,content
R7738 T24733 T24734 nsubjpass content,determined
R7739 T24734 T24720 conj determined,dried
R774 T3166 T3164 pobj QTL,as
R7740 T24735 T24734 auxpass was,determined
R7741 T24736 T24734 prep by,determined
R7742 T24737 T24736 pcomp subtracting,by
R7743 T24738 T24739 det the,weight
R7744 T24739 T24737 dobj weight,subtracting
R7745 T24740 T24741 npadvmod freeze,dried
R7746 T24741 T24739 amod dried,weight
R7747 T24742 T24741 punct -,dried
R7748 T24743 T24737 prep from,subtracting
R7749 T24744 T24743 pobj ECW,from
R775 T3299 T3298 prep of,members
R7750 T24745 T24720 punct .,dried
R7751 T24747 T24748 nsubjpass FAT,followed
R7752 T24749 T24748 auxpass was,followed
R7753 T24750 T24748 advmod then,followed
R7754 T24751 T24748 aux extracted,followed
R7755 T24752 T24748 prep with,followed
R7756 T24753 T24752 pobj ether,with
R7757 T24754 T24748 prep for,followed
R7758 T24755 T24756 nummod 7,days
R7759 T24756 T24754 pobj days,for
R776 T3300 T3301 det the,pathway
R7760 T24757 T24748 punct ", ",followed
R7761 T24758 T24748 agent by,followed
R7762 T24759 T24758 pobj acetone,by
R7763 T24760 T24748 prep for,followed
R7764 T24761 T24762 det an,days
R7765 T24762 T24760 pobj days,for
R7766 T24763 T24762 amod additional,days
R7767 T24764 T24762 nummod 7,days
R7768 T24765 T24748 prep in,followed
R7769 T24766 T24767 det a,apparatus
R777 T3301 T3299 pobj pathway,of
R7770 T24767 T24765 pobj apparatus,in
R7771 T24768 T24767 compound Soxhlet,apparatus
R7772 T24769 T24748 punct .,followed
R7773 T24771 T24772 compound Carcass,ash
R7774 T24772 T24773 nsubjpass ash,determined
R7775 T24774 T24772 punct (,ash
R7776 T24775 T24772 appos ASH,ash
R7777 T24776 T24773 punct ),determined
R7778 T24777 T24773 auxpass was,determined
R7779 T24778 T24773 advcl measuring,determined
R778 T3167 T3168 punct [,18
R7780 T24779 T24780 det the,remains
R7781 T24780 T24778 dobj remains,measuring
R7782 T24781 T24778 prep after,measuring
R7783 T24782 T24783 det a,incineration
R7784 T24783 T24781 pobj incineration,after
R7785 T24784 T24785 nummod 16,hour
R7786 T24785 T24783 compound hour,incineration
R7787 T24786 T24783 prep at,incineration
R7788 T24787 T24788 nummod 575,°C
R7789 T24788 T24786 pobj °C,at
R779 T3302 T3303 compound Gh,signaling
R7790 T24789 T24773 punct .,determined
R7791 T24791 T24792 compound Carcass,protein
R7792 T24792 T24793 nsubjpass protein,calculated
R7793 T24794 T24792 punct (,protein
R7794 T24795 T24792 appos PROT,protein
R7795 T24796 T24793 punct ),calculated
R7796 T24797 T24793 auxpass was,calculated
R7797 T24798 T24793 prep as,calculated
R7798 T24799 T24800 det the,portion
R7799 T24800 T24798 pobj portion,as
R780 T3303 T3301 compound signaling,pathway
R7800 T24801 T24800 amod remaining,portion
R7801 T24802 T24803 mark after,subtracted
R7802 T24803 T24800 advcl subtracted,portion
R7803 T24804 T24805 compound carcass,fat
R7804 T24805 T24803 nsubjpass fat,subtracted
R7805 T24806 T24805 punct (,fat
R7806 T24807 T24805 appos FAT,fat
R7807 T24808 T24805 punct ),fat
R7808 T24809 T24805 cc and,fat
R7809 T24810 T24805 conj ASH,fat
R781 T3304 T3272 punct .,is
R7810 T24811 T24803 auxpass were,subtracted
R7811 T24812 T24803 prep from,subtracted
R7812 T24813 T24812 pobj ECW,from
R7813 T24814 T24793 punct .,calculated
R7814 T25106 T25107 amod Statistical,analysis
R7815 T25109 T25110 det The,procedures
R7816 T25110 T25114 nsubjpass procedures,used
R7817 T25111 T25110 nmod MEANS,procedures
R7818 T25112 T25111 cc and,MEANS
R7819 T25113 T25111 conj UNIVARIATE,MEANS
R782 T3168 T3153 parataxis 18,referred
R7820 T25115 T25110 prep of,procedures
R7821 T25116 T25115 pobj SAS,of
R7822 T25117 T25114 auxpass were,used
R7823 T25118 T25119 aux to,generate
R7824 T25119 T25114 advcl generate,used
R7825 T25120 T25121 amod descriptive,statistics
R7826 T25121 T25119 dobj statistics,generate
R7827 T25122 T25119 cc and,generate
R7828 T25123 T25119 conj test,generate
R7829 T25124 T25125 compound normality,assumptions
R783 T3306 T3307 advmod Thus,has
R7830 T25125 T25123 dobj assumptions,test
R7831 T25126 T25125 prep for,assumptions
R7832 T25127 T25128 det each,trait
R7833 T25128 T25126 pobj trait,for
R7834 T25129 T25130 punct [,55
R7835 T25130 T25114 parataxis 55,used
R7836 T25131 T25130 punct ],55
R7837 T25132 T25114 punct .,used
R7838 T25134 T25135 det All,data
R7839 T25135 T25136 nsubjpass data,analyzed
R784 T3169 T3168 punct ],18
R7840 T25136 T25139 ccomp analyzed,used
R7841 T25137 T25136 auxpass were,analyzed
R7842 T25138 T25136 advmod then,analyzed
R7843 T25140 T25136 advcl using,analyzed
R7844 T25141 T25142 det the,procedure
R7845 T25142 T25140 dobj procedure,using
R7846 T25143 T25142 compound GLM,procedure
R7847 T25144 T25142 prep of,procedure
R7848 T25145 T25144 pobj SAS,of
R7849 T25146 T25147 punct [,55
R785 T3308 T3307 punct ", ",has
R7850 T25147 T25140 parataxis 55,using
R7851 T25148 T25147 punct ],55
R7852 T25149 T25140 prep with,using
R7853 T25150 T25151 det a,model
R7854 T25151 T25149 pobj model,with
R7855 T25152 T25151 amod linear,model
R7856 T25153 T25154 dep that,included
R7857 T25154 T25151 relcl included,model
R7858 T25155 T25156 det the,effects
R7859 T25156 T25154 dobj effects,included
R786 T3309 T3307 nsubj identification,has
R7860 T25157 T25156 amod fixed,effects
R7861 T25158 T25156 prep of,effects
R7862 T25159 T25158 pobj strain,of
R7863 T25160 T25159 punct ", ",strain
R7864 T25161 T25159 conj sex,strain
R7865 T25162 T25161 cc and,sex
R7866 T25163 T25164 nmod strain,interaction
R7867 T25164 T25161 conj interaction,sex
R7868 T25165 T25163 prep by,strain
R7869 T25166 T25165 pobj sex,by
R787 T3170 T3153 punct .,referred
R7870 T25167 T25139 punct ;,used
R7871 T25168 T25169 poss dam,weight
R7872 T25169 T25139 nsubjpass weight,used
R7873 T25170 T25168 case 's,dam
R7874 T25171 T25169 prep at,weight
R7875 T25172 T25171 pobj breeding,at
R7876 T25173 T25172 prep by,breeding
R7877 T25174 T25173 pobj strain,by
R7878 T25175 T25139 auxpass was,used
R7879 T25176 T25139 prep as,used
R788 T3310 T3309 prep of,identification
R7880 T25177 T25178 det a,covariate
R7881 T25178 T25176 pobj covariate,as
R7882 T25179 T25139 punct .,used
R7883 T25181 T25182 det A,model
R7884 T25182 T25185 nsubjpass model,used
R7885 T25183 T25182 amod second,model
R7886 T25184 T25182 amod linear,model
R7887 T25186 T25185 auxpass was,used
R7888 T25187 T25188 aux to,test
R7889 T25188 T25185 advcl test,used
R789 T3311 T3312 compound hg,modifiers
R7890 T25189 T25188 prep for,test
R7891 T25190 T25191 nmod strain,interactions
R7892 T25191 T25189 pobj interactions,for
R7893 T25192 T25190 prep by,strain
R7894 T25193 T25194 compound hg,genotype
R7895 T25194 T25192 pobj genotype,by
R7896 T25195 T25196 punct (,+
R7897 T25196 T25191 punct +,interactions
R7898 T25197 T25196 punct +,+
R7899 T25198 T25196 punct /,+
R790 T3312 T3310 pobj modifiers,of
R7900 T25199 T25196 cc or,+
R7901 T25200 T25201 compound hg,hg
R7902 T25201 T25196 conj hg,+
R7903 T25202 T25201 punct /,hg
R7904 T25203 T25196 punct ),+
R7905 T25204 T25185 punct .,used
R7906 T25206 T25207 det This,model
R7907 T25207 T25208 nsubj model,included
R7908 T25209 T25210 det the,effects
R7909 T25210 T25208 dobj effects,included
R791 T3172 T3173 compound Modifier,QTL
R7910 T25211 T25210 amod fixed,effects
R7911 T25212 T25210 prep of,effects
R7912 T25213 T25214 compound donor,region
R7913 T25214 T25212 pobj region,of
R7914 T25215 T25214 punct ", ",region
R7915 T25216 T25214 conj sex,region
R7916 T25217 T25216 cc and,sex
R7917 T25218 T25219 compound HG,genotype
R7918 T25219 T25216 conj genotype,sex
R7919 T25220 T25210 cc and,effects
R792 T3313 T3314 det the,potential
R7920 T25221 T25222 det all,interactions
R7921 T25222 T25210 conj interactions,effects
R7922 T25223 T25222 amod possible,interactions
R7923 T25224 T25225 nummod two,way
R7924 T25225 T25222 compound way,interactions
R7925 T25226 T25224 cc and,two
R7926 T25227 T25224 conj three,two
R7927 T25228 T25225 punct -,way
R7928 T25229 T25208 punct .,included
R7929 T25231 T25232 csubj Choosing,established
R793 T3314 T3307 dobj potential,has
R7930 T25233 T25234 det a,value
R7931 T25234 T25231 dobj value,Choosing
R7932 T25235 T25234 amod nominal,value
R7933 T25236 T25234 compound P,value
R7934 T25237 T25234 prep of,value
R7935 T25238 T25237 pobj 0.05,of
R7936 T25239 T25231 cc and,Choosing
R7937 T25240 T25231 conj applying,Choosing
R7938 T25241 T25242 det the,correction
R7939 T25242 T25240 dobj correction,applying
R794 T3315 T3316 aux to,uncover
R7940 T25243 T25242 compound Bonferroni,correction
R7941 T25244 T25242 prep for,correction
R7942 T25245 T25246 amod multiple,comparisons
R7943 T25246 T25244 pobj comparisons,for
R7944 T25247 T25248 amod significant,differences
R7945 T25248 T25232 dobj differences,established
R7946 T25249 T25248 prep in,differences
R7947 T25250 T25251 det the,ANOVA
R7948 T25251 T25249 pobj ANOVA,in
R7949 T25252 T25251 nmod 's,ANOVA
R795 T3316 T3314 acl uncover,potential
R7950 T25253 T25232 punct .,established
R7951 T25255 T25256 det The,values
R7952 T25256 T25259 nsubjpass values,indicated
R7953 T25257 T25256 amod critical,values
R7954 T25258 T25256 compound P,values
R7955 T25260 T25256 acl used,values
R7956 T25261 T25259 auxpass are,indicated
R7957 T25262 T25259 prep in,indicated
R7958 T25263 T25264 det each,table
R7959 T25264 T25262 pobj table,in
R796 T3173 T3174 nsubjpass QTL,mapped
R7960 T25265 T25259 punct .,indicated
R7961 T25441 T25440 prep of,Identification
R7962 T25442 T25443 compound candidate,genes
R7963 T25443 T25441 pobj genes,of
R7964 T25445 T25446 nsubjpass Genes,identified
R7965 T25447 T25446 auxpass were,identified
R7966 T25448 T25446 agent by,identified
R7967 T25449 T25450 amod manual,mining
R7968 T25450 T25448 pobj mining,by
R7969 T25451 T25450 compound data,mining
R797 T3317 T3318 amod novel,members
R7970 T25452 T25450 prep of,mining
R7971 T25453 T25454 amod primary,literature
R7972 T25454 T25452 pobj literature,of
R7973 T25455 T25454 punct ", ",literature
R7974 T25456 T25454 conj reviews,literature
R7975 T25457 T25456 cc and,reviews
R7976 T25458 T25459 compound book,chapters
R7977 T25459 T25456 conj chapters,reviews
R7978 T25460 T25446 punct .,identified
R7979 T25462 T25463 aux To,organize
R798 T3318 T3316 dobj members,uncover
R7980 T25463 T25464 advcl organize,created
R7981 T25465 T25463 cc and,organize
R7982 T25466 T25463 conj collate,organize
R7983 T25467 T25468 amod genomic,information
R7984 T25468 T25466 dobj information,collate
R7985 T25469 T25467 cc and,genomic
R7986 T25470 T25467 conj functional,genomic
R7987 T25471 T25468 prep for,information
R7988 T25472 T25473 det each,gene
R7989 T25473 T25471 pobj gene,for
R799 T3319 T3318 prep of,members
R7990 T25474 T25464 nsubj we,created
R7991 T25475 T25476 det a,Annotator
R7992 T25476 T25464 dobj Annotator,created
R7993 T25477 T25478 compound custom,Gh
R7994 T25478 T25479 compound Gh,signaling
R7995 T25479 T25476 compound signaling,Annotator
R7996 T25480 T25481 compound Gene,Map
R7997 T25481 T25476 compound Map,Annotator
R7998 T25482 T25476 cc and,Annotator
R7999 T25483 T25484 nmod Pathway,Profiler
R800 T3320 T3321 advmod metabolically,important
R8000 T25484 T25485 nmod Profiler,pathway
R8001 T25485 T25476 conj pathway,Annotator
R8002 T25486 T25487 punct (,GenMAPP
R8003 T25487 T25484 parataxis GenMAPP,Profiler
R8004 T25488 T25487 punct ),GenMAPP
R8005 T25489 T25490 punct [,56
R8006 T25490 T25464 parataxis 56,created
R8007 T25491 T25490 punct ],56
R8008 T25492 T25493 punct (,Figure
R8009 T25493 T25464 parataxis Figure,created
R801 T3321 T3322 amod important,pathways
R8010 T25494 T25493 nummod 5,Figure
R8011 T25495 T25493 punct ),Figure
R8012 T25496 T25464 punct .,created
R8013 T25498 T25499 nsubj Visualization,aided
R8014 T25500 T25498 cc and,Visualization
R8015 T25501 T25498 conj color,Visualization
R8016 T25502 T25501 punct -,color
R8017 T25503 T25501 amod coding,color
R8018 T25504 T25498 prep of,Visualization
R8019 T25505 T25504 pobj genes,of
R802 T3322 T3319 pobj pathways,of
R8020 T25506 T25498 acl using,Visualization
R8021 T25507 T25506 dobj GenMAPP,using
R8022 T25508 T25509 det the,selection
R8023 T25509 T25499 dobj selection,aided
R8024 T25510 T25509 prep of,selection
R8025 T25511 T25512 compound candidate,genes
R8026 T25512 T25510 pobj genes,of
R8027 T25513 T25512 acl mapping,genes
R8028 T25514 T25513 prep within,mapping
R8029 T25515 T25516 compound QTL,regions
R803 T3175 T3174 aux have,mapped
R8030 T25516 T25514 pobj regions,within
R8031 T25517 T25516 prep on,regions
R8032 T25518 T25519 nmod MMU,2
R8033 T25519 T25517 pobj 2,on
R8034 T25520 T25519 punct ", ",2
R8035 T25521 T25519 conj 9,2
R8036 T25522 T25521 punct ", ",9
R8037 T25523 T25521 conj 11,9
R8038 T25524 T25523 cc and,11
R8039 T25525 T25523 conj 17,11
R804 T3323 T3318 cc or,members
R8040 T25526 T25499 punct .,aided
R8043 T26350 T26351 compound Candidate,gene
R8044 T26351 T26352 compound gene,sequencing
R8045 T26354 T26355 compound PCR,amplicons
R8046 T26355 T26356 nsubjpass amplicons,amplified
R8047 T26357 T26355 acl covering,amplicons
R8048 T26358 T26359 det the,sequence
R8049 T26359 T26357 dobj sequence,covering
R805 T3324 T3325 advmod previously,unknown
R8050 T26360 T26359 compound coding,sequence
R8051 T26361 T26355 cc and,amplicons
R8052 T26362 T26363 amod partial,regions
R8053 T26363 T26355 conj regions,amplicons
R8054 T26364 T26363 nummod 5,regions
R8055 T26365 T26364 punct ',5
R8056 T26366 T26364 cc and,5
R8057 T26367 T26364 conj 3,5
R8058 T26368 T26367 punct ',3
R8059 T26369 T26363 amod untranslated,regions
R806 T3325 T3326 amod unknown,convergences
R8060 T26370 T26363 prep for,regions
R8061 T26371 T26372 det each,gene
R8062 T26372 T26370 pobj gene,for
R8063 T26373 T26372 amod selected,gene
R8064 T26374 T26372 compound candidate,gene
R8065 T26375 T26356 auxpass were,amplified
R8066 T26376 T26356 punct ", ",amplified
R8067 T26377 T26356 conj purified,amplified
R8068 T26378 T26377 cc and,purified
R8069 T26379 T26377 conj sequenced,purified
R807 T3176 T3174 auxpass been,mapped
R8070 T26380 T26379 prep from,sequenced
R8071 T26381 T26382 det the,strain
R8072 T26382 T26380 pobj strain,from
R8073 T26383 T26382 compound CAST,strain
R8074 T26384 T26379 advcl using,sequenced
R8075 T26385 T26384 dobj protocols,using
R8076 T26386 T26385 acl outlined,protocols
R8077 T26387 T26386 prep in,outlined
R8078 T26388 T26389 punct [,57
R8079 T26389 T26387 pobj 57,in
R808 T3177 T3174 prep for,mapped
R8080 T26390 T26389 punct ],57
R8081 T26391 T26385 prep with,protocols
R8082 T26392 T26393 amod slight,modifications
R8083 T26393 T26391 pobj modifications,with
R8084 T26394 T26356 punct .,amplified
R8085 T26396 T26397 amod Total,RNA
R8086 T26397 T26398 nsubjpass RNA,isolated
R8087 T26399 T26397 prep from,RNA
R8088 T26400 T26399 pobj brain,from
R8089 T26401 T26400 punct ", ",brain
R809 T3326 T3318 conj convergences,members
R8090 T26402 T26400 conj liver,brain
R8091 T26403 T26402 punct ", ",liver
R8092 T26404 T26402 conj spleen,liver
R8093 T26405 T26404 punct ", ",spleen
R8094 T26406 T26404 conj lung,spleen
R8095 T26407 T26406 cc and,lung
R8096 T26408 T26406 conj testis,lung
R8097 T26409 T26398 auxpass was,isolated
R8098 T26410 T26398 prep from,isolated
R8099 T26411 T26412 det an,mouse
R810 T3178 T3179 amod numerous,traits
R8100 T26412 T26410 pobj mouse,from
R8101 T26413 T26412 amod adult,mouse
R8102 T26414 T26412 nmod CAST,mouse
R8103 T26415 T26412 amod male,mouse
R8104 T26416 T26398 advcl using,isolated
R8105 T26417 T26416 dobj Trizol,using
R8106 T26418 T26419 punct (,Ambion
R8107 T26419 T26417 parataxis Ambion,Trizol
R8108 T26420 T26419 punct ),Ambion
R8109 T26421 T26398 punct .,isolated
R811 T3327 T3326 prep between,convergences
R8110 T26423 T26424 nsubjpass cDNA,produced
R8111 T26425 T26424 auxpass was,produced
R8112 T26426 T26424 prep from,produced
R8113 T26427 T26428 amod total,RNA
R8114 T26428 T26426 pobj RNA,from
R8115 T26429 T26424 advcl using,produced
R8116 T26430 T26431 amod standard,procedures
R8117 T26431 T26429 dobj procedures,using
R8118 T26432 T26424 punct .,produced
R8119 T26434 T26435 compound PCR,sets
R812 T3328 T3327 pobj pathways,between
R8120 T26435 T26437 nsubjpass sets,designed
R8121 T26436 T26435 compound primer,sets
R8122 T26438 T26435 prep for,sets
R8123 T26439 T26440 det each,gene
R8124 T26440 T26438 pobj gene,for
R8125 T26441 T26437 auxpass were,designed
R8126 T26442 T26437 advcl using,designed
R8127 T26443 T26442 dobj Primer3,using
R8128 T26444 T26445 punct [,58
R8129 T26445 T26437 parataxis 58,designed
R813 T3329 T3307 punct .,has
R8130 T26446 T26445 punct ],58
R8131 T26447 T26448 punct (,File
R8132 T26448 T26437 parataxis File,designed
R8133 T26449 T26448 amod Additional,File
R8134 T26450 T26448 nummod 5,File
R8135 T26451 T26448 punct ),File
R8136 T26452 T26437 punct .,designed
R8137 T26454 T26455 det The,amplification
R8138 T26455 T26457 nsubjpass amplification,performed
R8139 T26456 T26455 amod initial,amplification
R814 T3179 T3177 pobj traits,for
R8140 T26458 T26457 auxpass was,performed
R8141 T26459 T26457 prep in,performed
R8142 T26460 T26461 nummod 10,μl
R8143 T26461 T26462 compound μl,reactions
R8144 T26462 T26459 pobj reactions,in
R8145 T26463 T26462 compound PCR,reactions
R8146 T26464 T26457 advcl using,performed
R8147 T26465 T26466 det the,system
R8148 T26466 T26464 dobj system,using
R8149 T26467 T26466 compound Invitrogen,system
R815 T3331 T3332 prep As,identified
R8150 T26468 T26466 compound Platinum,system
R8151 T26469 T26470 compound TaqPCRx,amplification
R8152 T26470 T26466 compound amplification,system
R8153 T26471 T26472 punct (,Invitrogen
R8154 T26472 T26466 parataxis Invitrogen,system
R8155 T26473 T26472 punct ),Invitrogen
R8156 T26474 T26457 punct .,performed
R8157 T26476 T26477 det The,reactions
R8158 T26477 T26478 nsubj reactions,contained
R8159 T26479 T26480 compound 1X,buffer
R816 T3180 T3174 cc and,mapped
R8160 T26480 T26478 dobj buffer,contained
R8161 T26481 T26480 compound PCR,buffer
R8162 T26482 T26480 punct ", ",buffer
R8163 T26483 T26484 compound 1X,solution
R8164 T26484 T26480 conj solution,buffer
R8165 T26485 T26484 compound Enhancer,solution
R8166 T26486 T26484 punct ", ",solution
R8167 T26487 T26488 nummod 1.5,mM
R8168 T26488 T26489 compound mM,MgSO4
R8169 T26489 T26484 conj MgSO4,solution
R817 T3333 T3334 det an,step
R8170 T26490 T26489 punct ", ",MgSO4
R8171 T26491 T26492 nummod 0.17,mM
R8172 T26492 T26493 compound mM,dNTPs
R8173 T26493 T26489 conj dNTPs,MgSO4
R8174 T26494 T26493 punct ", ",dNTPs
R8175 T26495 T26496 nummod 1,μM
R8176 T26496 T26497 nmod μM,primer
R8177 T26497 T26493 conj primer,dNTPs
R8178 T26498 T26497 det each,primer
R8179 T26499 T26497 punct ", ",primer
R818 T3334 T3331 pobj step,As
R8180 T26500 T26501 nummod 0.1,unit
R8181 T26501 T26497 conj unit,primer
R8182 T26502 T26501 prep of,unit
R8183 T26503 T26504 compound Platinum,Taq
R8184 T26504 T26502 pobj Taq,of
R8185 T26505 T26506 punct (,Invitrogen
R8186 T26506 T26504 parataxis Invitrogen,Taq
R8187 T26507 T26506 punct ),Invitrogen
R8188 T26508 T26501 cc and,unit
R8189 T26509 T26510 advmod approximately,25
R819 T3181 T3182 prep in,is
R8190 T26510 T26511 nummod 25,ng
R8191 T26511 T26501 conj ng,unit
R8192 T26512 T26511 prep of,ng
R8193 T26513 T26512 pobj cDNA,of
R8194 T26514 T26478 punct .,contained
R8195 T26516 T26517 nsubjpass Reactions,incubated
R8196 T26518 T26517 auxpass were,incubated
R8197 T26519 T26517 prep for,incubated
R8198 T26520 T26521 nummod 5,min
R8199 T26521 T26519 pobj min,for
R820 T3335 T3334 amod initial,step
R8200 T26522 T26517 prep at,incubated
R8201 T26523 T26524 nummod 95,°C
R8202 T26524 T26522 pobj °C,at
R8203 T26525 T26517 punct ", ",incubated
R8204 T26526 T26527 advmod then,cycled
R8205 T26527 T26517 dep cycled,incubated
R8206 T26528 T26527 prep for,cycled
R8207 T26529 T26530 nummod 45,s
R8208 T26530 T26528 pobj s,for
R8209 T26531 T26530 prep at,s
R821 T3336 T3332 punct ", ",identified
R8210 T26532 T26533 nummod 95,°C
R8211 T26533 T26531 pobj °C,at
R8212 T26534 T26530 punct ", ",s
R8213 T26535 T26536 nummod 45,s
R8214 T26536 T26530 appos s,s
R8215 T26537 T26536 prep at,s
R8216 T26538 T26539 nummod 55,°C
R8217 T26539 T26537 pobj °C,at
R8218 T26540 T26530 punct ", ",s
R8219 T26541 T26542 nummod 1,min
R822 T3337 T3338 nmod growth,QTL
R8220 T26542 T26530 appos min,s
R8221 T26543 T26542 prep at,min
R8222 T26544 T26545 nummod 72,°C
R8223 T26545 T26543 pobj °C,at
R8224 T26546 T26542 prep for,min
R8225 T26547 T26548 nummod 35,cycles
R8226 T26548 T26546 pobj cycles,for
R8227 T26549 T26527 prep with,cycled
R8228 T26550 T26551 det a,extension
R8229 T26551 T26549 pobj extension,with
R823 T3182 T3174 conj is,mapped
R8230 T26552 T26551 amod final,extension
R8231 T26553 T26554 nummod 72,°C
R8232 T26554 T26551 compound °C,extension
R8233 T26555 T26551 prep for,extension
R8234 T26556 T26557 nummod 10,min
R8235 T26557 T26555 pobj min,for
R8236 T26558 T26551 prep on,extension
R8237 T26559 T26560 det a,PTC
R8238 T26560 T26558 pobj PTC,on
R8239 T26561 T26562 compound MJ,Research
R824 T3338 T3332 nsubjpass QTL,identified
R8240 T26562 T26560 compound Research,PTC
R8241 T26563 T26560 punct -,PTC
R8242 T26564 T26560 nummod 200,PTC
R8243 T26565 T26517 punct .,incubated
R8244 T26567 T26568 det The,products
R8245 T26568 T26569 nsubjpass products,visualized
R8246 T26570 T26569 auxpass were,visualized
R8247 T26571 T26569 prep on,visualized
R8248 T26572 T26573 nummod 1.5,%
R8249 T26573 T26574 compound %,agarose
R825 T3339 T3337 cc and,growth
R8250 T26574 T26575 compound agarose,gels
R8251 T26575 T26571 pobj gels,on
R8252 T26576 T26575 acl containing,gels
R8253 T26577 T26578 nummod 0.06,μg
R8254 T26578 T26579 nmod μg,EtBr
R8255 T26579 T26576 dobj EtBr,containing
R8256 T26580 T26581 punct /,ml
R8257 T26581 T26578 prep ml,μg
R8258 T26582 T26569 punct .,visualized
R8259 T26584 T26585 nsubjpass Bands,excised
R826 T3340 T3341 compound carcass,composition
R8260 T26586 T26584 prep of,Bands
R8261 T26587 T26588 det the,size
R8262 T26588 T26586 pobj size,of
R8263 T26589 T26588 amod correct,size
R8264 T26590 T26585 auxpass were,excised
R8265 T26591 T26585 cc and,excised
R8266 T26592 T26585 conj incubated,excised
R8267 T26593 T26592 prep in,incubated
R8268 T26594 T26595 nummod 100,μl
R8269 T26595 T26593 pobj μl,in
R827 T3183 T3184 det these,studies
R8270 T26596 T26595 prep of,μl
R8271 T26597 T26598 amod sterile,H2O
R8272 T26598 T26596 pobj H2O,of
R8273 T26599 T26598 prep at,H2O
R8274 T26600 T26601 nummod 80,°C
R8275 T26601 T26599 pobj °C,at
R8276 T26602 T26592 prep for,incubated
R8277 T26603 T26604 nummod 10,min
R8278 T26604 T26602 pobj min,for
R8279 T26605 T26606 aux to,elute
R828 T3341 T3337 conj composition,growth
R8280 T26606 T26592 advcl elute,incubated
R8281 T26607 T26606 dobj DNA,elute
R8282 T26608 T26585 punct .,excised
R8283 T26610 T26611 compound Reamplification,reactions
R8284 T26611 T26612 nsubj reactions,consisted
R8285 T26613 T26612 prep of,consisted
R8286 T26614 T26615 compound 1X,buffer
R8287 T26615 T26613 pobj buffer,of
R8288 T26616 T26615 compound PCR,buffer
R8289 T26617 T26615 punct ", ",buffer
R829 T3342 T3332 auxpass were,identified
R8290 T26618 T26619 nummod 1.5,mM
R8291 T26619 T26620 compound mM,MgCl2
R8292 T26620 T26615 conj MgCl2,buffer
R8293 T26621 T26620 punct ", ",MgCl2
R8294 T26622 T26623 nummod 0.17,mM
R8295 T26623 T26624 compound mM,dNTPs
R8296 T26624 T26620 conj dNTPs,MgCl2
R8297 T26625 T26624 punct ", ",dNTPs
R8298 T26626 T26627 nummod 1,μM
R8299 T26627 T26628 nmod μM,primer
R830 T3343 T3332 prep in,identified
R8300 T26628 T26624 conj primer,dNTPs
R8301 T26629 T26628 det each,primer
R8302 T26630 T26628 punct ", ",primer
R8303 T26631 T26632 nummod 0.1,unit
R8304 T26632 T26628 conj unit,primer
R8305 T26633 T26632 prep of,unit
R8306 T26634 T26633 pobj Taq,of
R8307 T26635 T26636 punct (,Promega
R8308 T26636 T26634 parataxis Promega,Taq
R8309 T26637 T26636 punct ),Promega
R831 T3184 T3181 pobj studies,in
R8310 T26638 T26632 cc and,unit
R8311 T26639 T26640 nummod 10,μl
R8312 T26640 T26632 conj μl,unit
R8313 T26641 T26640 prep of,μl
R8314 T26642 T26641 pobj eluate,of
R8315 T26643 T26615 prep in,buffer
R8316 T26644 T26645 det a,volume
R8317 T26645 T26643 pobj volume,in
R8318 T26646 T26645 amod total,volume
R8319 T26647 T26645 prep of,volume
R832 T3344 T3345 det a,cross
R8320 T26648 T26649 nummod 50,μl
R8321 T26649 T26647 pobj μl,of
R8322 T26650 T26612 punct .,consisted
R8323 T26652 T26653 det The,parameters
R8324 T26653 T26656 nsubjpass parameters,used
R8325 T26654 T26653 amod same,parameters
R8326 T26655 T26653 compound cycling,parameters
R8327 T26657 T26656 auxpass were,used
R8328 T26658 T26656 prep for,used
R8329 T26659 T26660 compound reamplification,reactions
R833 T3345 T3343 pobj cross,in
R8330 T26660 T26658 pobj reactions,for
R8331 T26661 T26656 punct .,used
R8332 T26663 T26664 nsubjpass Products,visualized
R8333 T26665 T26664 auxpass were,visualized
R8334 T26666 T26664 prep on,visualized
R8335 T26667 T26668 nummod 1,%
R8336 T26668 T26669 compound %,gels
R8337 T26669 T26666 pobj gels,on
R8338 T26670 T26669 compound 0.5X,gels
R8339 T26671 T26669 compound TBE,gels
R834 T3346 T3345 prep between,cross
R8340 T26672 T26669 compound agarose,gels
R8341 T26673 T26669 acl containing,gels
R8342 T26674 T26675 nummod 0.06,μg
R8343 T26675 T26676 nmod μg,EtBr
R8344 T26676 T26673 dobj EtBr,containing
R8345 T26677 T26678 punct /,ml
R8346 T26678 T26675 prep ml,μg
R8347 T26679 T26664 punct ", ",visualized
R8348 T26680 T26664 conj excised,visualized
R8349 T26681 T26680 cc and,excised
R835 T3185 T3186 det the,locus
R8350 T26682 T26680 conj purfied,excised
R8351 T26683 T26682 advcl using,purfied
R8352 T26684 T26685 compound PCR,purification
R8353 T26685 T26686 compound purification,columns
R8354 T26686 T26683 dobj columns,using
R8355 T26687 T26688 punct (,Promega
R8356 T26688 T26686 parataxis Promega,columns
R8357 T26689 T26688 punct ),Promega
R8358 T26690 T26664 punct .,visualized
R8359 T26692 T26693 aux To,quantity
R836 T3347 T3348 compound CAST,EiJ
R8360 T26693 T26694 advcl quantity,run
R8361 T26695 T26696 det each,fragment
R8362 T26696 T26693 dobj fragment,quantity
R8363 T26697 T26698 nummod 1,μl
R8364 T26698 T26694 nsubjpass μl,run
R8365 T26699 T26698 prep of,μl
R8366 T26700 T26701 det each,product
R8367 T26701 T26699 pobj product,of
R8368 T26702 T26701 amod purified,product
R8369 T26703 T26694 auxpass was,run
R837 T3348 T3346 pobj EiJ,between
R8370 T26704 T26694 prep on,run
R8371 T26705 T26706 det a,gel
R8372 T26706 T26704 pobj gel,on
R8373 T26707 T26708 nummod 1.0,%
R8374 T26708 T26706 compound %,gel
R8375 T26709 T26706 compound agarose,gel
R8376 T26710 T26706 acl containing,gel
R8377 T26711 T26712 nummod 0.06,μg
R8378 T26712 T26713 nmod μg,EtBr
R8379 T26713 T26710 dobj EtBr,containing
R838 T3349 T3348 punct /,EiJ
R8380 T26714 T26715 punct /,ml
R8381 T26715 T26712 prep ml,μg
R8382 T26716 T26706 punct ", ",gel
R8383 T26717 T26706 prep along,gel
R8384 T26718 T26717 prep with,along
R8385 T26719 T26720 det a,ladder
R8386 T26720 T26718 pobj ladder,with
R8387 T26721 T26720 compound DNA,ladder
R8388 T26722 T26720 compound mass,ladder
R8389 T26723 T26724 punct (,Invitrogen
R839 T3186 T3182 nsubj locus,is
R8390 T26724 T26720 parataxis Invitrogen,ladder
R8391 T26725 T26724 punct ),Invitrogen
R8392 T26726 T26694 punct .,run
R8393 T26728 T26729 prep In,added
R8394 T26730 T26731 det a,plate
R8395 T26731 T26728 pobj plate,In
R8396 T26732 T26733 nummod 96,well
R8397 T26733 T26731 compound well,plate
R8398 T26734 T26729 punct ", ",added
R8399 T26735 T26736 nummod 15,ng
R840 T3350 T3348 punct (,EiJ
R8400 T26736 T26729 nsubjpass ng,added
R8401 T26737 T26736 prep of,ng
R8402 T26738 T26739 det each,product
R8403 T26739 T26737 pobj product,of
R8404 T26740 T26739 compound PCR,product
R8405 T26741 T26729 auxpass was,added
R8406 T26742 T26729 prep to,added
R8407 T26743 T26744 nummod 5,pM
R8408 T26744 T26742 pobj pM,to
R8409 T26745 T26744 prep of,pM
R841 T3351 T3348 appos CAST,EiJ
R8410 T26746 T26745 pobj primer,of
R8411 T26747 T26729 prep for,added
R8412 T26748 T26747 pobj sequencing,for
R8413 T26749 T26729 punct .,added
R8414 T26751 T26752 det The,College
R8415 T26752 T26753 nmod College,Facility
R8416 T26753 T26763 nsubj Facility,performed
R8417 T26754 T26752 prep of,College
R8418 T26755 T26756 nmod Agriculture,Sciences
R8419 T26756 T26754 pobj Sciences,of
R842 T3352 T3348 punct ),EiJ
R8420 T26757 T26755 cc and,Agriculture
R8421 T26758 T26755 conj Environmental,Agriculture
R8422 T26759 T26752 punct (,College
R8423 T26760 T26752 appos CAES,College
R8424 T26761 T26753 punct ),Facility
R8425 T26762 T26753 compound Genomics,Facility
R8426 T26764 T26753 prep at,Facility
R8427 T26765 T26766 det the,University
R8428 T26766 T26764 pobj University,at
R8429 T26767 T26766 prep of,University
R843 T3187 T3186 amod modified,locus
R8430 T26768 T26767 pobj California,of
R8431 T26769 T26766 punct ", ",University
R8432 T26770 T26766 npadvmod Davis,University
R8433 T26771 T26763 punct ", ",performed
R8434 T26772 T26773 amod bidirectional,sequencing
R8435 T26773 T26763 dobj sequencing,performed
R8436 T26774 T26773 prep of,sequencing
R8437 T26775 T26776 det each,amplicon
R8438 T26776 T26774 pobj amplicon,of
R8439 T26777 T26763 punct .,performed
R844 T3353 T3348 cc and,EiJ
R8440 T26935 T26936 compound Sequence,analysis
R8441 T26938 T26939 compound B6,sequences
R8442 T26939 T26941 nsubjpass sequences,downloaded
R8443 T26940 T26939 compound mRNA,sequences
R8444 T26942 T26939 prep for,sequences
R8445 T26943 T26944 det each,gene
R8446 T26944 T26942 pobj gene,for
R8447 T26945 T26941 auxpass were,downloaded
R8448 T26946 T26941 prep from,downloaded
R8449 T26947 T26948 det the,assembly
R845 T3354 T3348 conj HG,EiJ
R8450 T26948 T26946 pobj assembly,from
R8451 T26949 T26948 nmod May,assembly
R8452 T26950 T26949 nummod 2004,May
R8453 T26951 T26952 punct (,mm5
R8454 T26952 T26948 parataxis mm5,assembly
R8455 T26953 T26952 punct ),mm5
R8456 T26954 T26948 nmod UCSC,assembly
R8457 T26955 T26956 punct (,Build
R8458 T26956 T26948 parataxis Build,assembly
R8459 T26957 T26956 compound NCBI,Build
R846 T3355 T3356 punct [,24
R8460 T26958 T26956 nummod 33,Build
R8461 T26959 T26956 punct ),Build
R8462 T26960 T26948 compound genome,assembly
R8463 T26961 T26962 punct [,28
R8464 T26962 T26941 parataxis 28,downloaded
R8465 T26963 T26962 punct ],28
R8466 T26964 T26941 punct .,downloaded
R8467 T26966 T26967 det These,sequences
R8468 T26967 T26968 nsubjpass sequences,imported
R8469 T26969 T26968 auxpass were,imported
R847 T3188 T3182 advmod typically,is
R8470 T26970 T26968 prep along,imported
R8471 T26971 T26970 prep with,along
R8472 T26972 T26973 det all,traces
R8473 T26973 T26971 pobj traces,with
R8474 T26974 T26975 compound CAST,sequence
R8475 T26975 T26973 compound sequence,traces
R8476 T26976 T26968 prep into,imported
R8477 T26977 T26978 det the,program
R8478 T26978 T26976 pobj program,into
R8479 T26979 T26978 compound SeqMan,program
R848 T3356 T3332 parataxis 24,identified
R8480 T26980 T26981 compound sequence,assembly
R8481 T26981 T26978 compound assembly,program
R8482 T26982 T26983 punct (,DNASTAR
R8483 T26983 T26978 parataxis DNASTAR,program
R8484 T26984 T26983 punct ),DNASTAR
R8485 T26985 T26968 cc and,imported
R8486 T26986 T26987 advmod manually,curated
R8487 T26987 T26968 conj curated,imported
R8488 T26988 T26987 prep for,curated
R8489 T26989 T26988 pobj quality,for
R849 T3357 T3356 punct ],24
R8490 T26990 T26968 punct .,imported
R8491 T26992 T26993 amod Poor,quality
R8492 T26993 T26994 compound quality,reads
R8493 T26994 T26995 nsubjpass reads,resequenced
R8494 T26996 T26995 auxpass were,resequenced
R8495 T26997 T26995 punct .,resequenced
R8496 T26999 T27000 amod Individual,contigs
R8497 T27000 T27001 nsubjpass contigs,created
R8498 T27002 T27001 auxpass were,created
R8499 T27003 T27001 prep for,created
R850 T3358 T3332 punct .,identified
R8500 T27004 T27005 det each,gene
R8501 T27005 T27003 pobj gene,for
R8502 T27006 T27001 cc and,created
R8503 T27007 T27008 nsubjpass polymorphisms,detected
R8504 T27008 T27001 conj detected,created
R8505 T27009 T27008 auxpass were,detected
R8506 T27010 T27008 cc and,detected
R8507 T27011 T27008 conj curated,detected
R8508 T27012 T27011 prep by,curated
R8509 T27013 T27014 amod manual,inspection
R851 T3189 T3190 det a,gene
R8510 T27014 T27012 pobj inspection,by
R8511 T27015 T27008 punct .,detected
R852 T3360 T3361 prep In,assayed
R853 T3362 T3363 det the,F2
R854 T3363 T3360 pobj F2,In
R855 T3364 T3361 punct ", ",assayed
R856 T3190 T3182 attr gene,is
R857 T3365 T3361 nsubjpass mice,assayed
R858 T3366 T3365 amod homozygous,mice
R859 T3191 T3190 amod known,gene
R860 T3367 T3366 prep for,homozygous
R861 T3192 T3190 acl containing,gene
R862 T3368 T3369 det the,deletion
R863 T3369 T3367 pobj deletion,for
R864 T3193 T3194 det a,mutation
R865 T3370 T3369 compound hg,deletion
R866 T3371 T3372 punct (,hg
R867 T3372 T3369 parataxis hg,deletion
R868 T3194 T3192 dobj mutation,containing
R869 T3373 T3372 compound hg,hg
R870 T3374 T3372 punct /,hg
R871 T3375 T3372 punct ),hg
R872 T3195 T3196 advmod spontaneously,arisen
R873 T3376 T3366 cc and,homozygous
R874 T3196 T3194 amod arisen,mutation
R875 T3377 T3378 amod wild,type
R876 T3378 T3366 conj type,homozygous
R877 T3379 T3378 punct (,type
R878 T3380 T3381 punct +,+
R879 T3197 T3196 cc or,arisen
R880 T3381 T3378 appos +,type
R881 T3382 T3381 punct /,+
R882 T3383 T3361 punct ),assayed
R883 T3198 T3196 conj engineered,arisen
R884 T3384 T3361 auxpass were,assayed
R885 T3385 T3361 cc and,assayed
R886 T3199 T3194 prep with,mutation
R887 T3386 T3387 compound hg,modifier
R888 T3387 T3388 compound modifier,QTL
R889 T3388 T3389 nsubjpass QTL,defined
R890 T3389 T3361 conj defined,assayed
R891 T3200 T3201 amod major,effects
R892 T3390 T3389 auxpass were,defined
R893 T3391 T3389 prep as,defined
R894 T3392 T3391 pobj those,as
R895 T3201 T3199 pobj effects,with
R896 T3393 T3392 preconj either,those
R897 T3394 T3392 amod absent,those
R898 T3202 T3201 amod phenotypic,effects
R899 T3395 T3394 prep in,absent
R900 T3396 T3397 punct +,+
R901 T3397 T3399 punct +,mice
R902 T3398 T3397 punct /,+
R903 T3203 T3194 punct ", ",mutation
R904 T3399 T3395 pobj mice,in
R905 T3400 T3394 cc and,absent
R906 T3401 T3394 conj segregating,absent
R907 T3402 T3401 prep in,segregating
R908 T3403 T3404 compound hg,hg
R909 T3404 T3402 pobj hg,in
R910 T3204 T3205 amod such,as
R911 T3405 T3404 punct /,hg
R912 T3406 T3392 cc or,those
R913 T3407 T3392 conj loci,those
R914 T3408 T3407 prep with,loci
R915 T3205 T3194 prep as,mutation
R916 T3409 T3410 amod altered,action
R917 T3410 T3408 pobj action,with
R918 T3411 T3410 compound gene,action
R919 T3206 T3205 pobj hg,as
R920 T3412 T3410 amod dependent,action
R921 T3413 T3412 prep on,dependent
R922 T3414 T3413 pobj background,on
R923 T3207 T3208 punct [,11
R924 T3415 T3389 punct .,defined
R925 T3208 T3182 parataxis 11,is
R926 T3417 T3418 nummod Four,hg
R927 T3418 T3419 compound hg,QTL
R928 T3419 T3421 nsubjpass QTL,identified
R929 T3420 T3419 compound modifier,QTL
R930 T3209 T3208 punct ",",11
R931 T3422 T3419 punct (,QTL
R932 T3423 T3419 appos Wg2,QTL
R933 T3210 T3208 appos 19,11
R934 T3424 T3423 prep on,Wg2
R935 T3425 T3424 pobj MMU2,on
R936 T3426 T3423 punct ", ",Wg2
R937 T3211 T3212 punct -,21
R938 T3427 T3423 conj Carfhg2,Wg2
R939 T3428 T3427 prep on,Carfhg2
R940 T3429 T3428 pobj MMU9,on
R941 T3212 T3210 prep 21,19
R942 T3430 T3427 punct ", ",Carfhg2
R943 T3213 T3208 punct ],11
R944 T3214 T3182 punct .,is
R945 T3431 T3427 conj Carp2,Carfhg2
R946 T3216 T3217 nsubj Epistasis,forms
R947 T3432 T3431 prep on,Carp2
R948 T3433 T3432 pobj MMU11,on
R949 T3434 T3431 cc and,Carp2
R950 T3435 T3431 conj Feml3,Carp2
R951 T3218 T3219 det the,basis
R952 T3436 T3435 prep on,Feml3
R953 T3437 T3436 pobj MMU17,on
R954 T3438 T3419 punct ),QTL
R955 T3219 T3217 dobj basis,forms
R956 T3439 T3421 auxpass were,identified
R957 T3440 T3421 punct ", ",identified
R958 T3441 T3421 prep along,identified
R959 T3442 T3441 prep with,along
R960 T3443 T3444 nummod 12,QTL
R961 T3444 T3442 pobj QTL,with
R962 T3445 T3444 amod additional,QTL
R963 T3537 T3536 prep of,outside
R964 T3446 T3444 punct (,QTL
R965 T3447 T3444 appos Q1Ucd1,QTL
R966 T3448 T3447 prep on,Q1Ucd1
R967 T3538 T3537 pobj MMU2,of
R968 T3449 T3448 pobj MMU1,on
R969 T3450 T3444 punct (,QTL
R970 T3539 T3526 punct ", ",created
R971 T3451 T3452 dep which,reached
R972 T3452 T3444 relcl reached,QTL
R973 T3453 T3452 advmod only,reached
R974 T3540 T3541 mark while,developed
R975 T3454 T3455 det a,level
R976 T3455 T3452 dobj level,reached
R977 T3456 T3455 amod suggestive,level
R978 T3541 T3526 advcl developed,created
R979 T3457 T3455 prep of,level
R980 T3458 T3459 amod statistical,significance
R981 T3459 T3457 pobj significance,of
R982 T3460 T3444 punct ),QTL
R983 T3542 T3543 det a,panel
R984 T3461 T3444 punct ", ",QTL
R985 T3462 T3444 appos Wg1,QTL
R986 T3543 T3541 nsubjpass panel,developed
R987 T3463 T3462 punct ", ",Wg1
R988 T3464 T3462 conj Carp1,Wg1
R989 T3465 T3464 punct ", ",Carp1
R990 T3544 T3543 amod comprehensive,panel
R991 T3466 T3464 conj Cara1,Carp1
R992 T3467 T3466 cc and,Cara1
R993 T3468 T3466 conj Feml1,Cara1
R994 T3545 T3543 prep of,panel
R995 T3469 T3466 prep on,Cara1
R996 T3470 T3469 pobj MMU2,on
R997 T3471 T3466 punct ", ",Cara1
R998 T3546 T3547 amod overlapping,strains
R999 T3472 T3466 conj Carfhg1,Cara1